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Sample records for plane systolic excursion

  1. Tricuspid annular plane systolic excursion and response to cardiac resynchronization therapy

    DEFF Research Database (Denmark)

    Kjaergaard, Jesper; Ghio, Stefano; St John Sutton, Martin

    2011-01-01

    The aims of this study were to evaluate tricuspid annular plane systolic excursion (TAPSE) as a predictor of left ventricular (LV) reverse remodeling and clinical benefit of cardiac synchronization therapy (CRT) and to evaluate the effect of CRT on TAPSE in patients with mildly symptomatic systol...

  2. Predictors of right ventricular function as measured by tricuspid annular plane systolic excursion in heart failure

    Directory of Open Access Journals (Sweden)

    Køber Lars V

    2009-11-01

    Full Text Available Abstract Introduction Tricuspid Annular Plane Systolic Excursion (TAPSE has independent prognostic value in heart failure patients but may be influenced by left ventricular (LV ejection fraction. The present study assessed the association of TAPSE and clinical factors, global and regional LV function in 634 patients admitted for symptomatic heart failure. Methods & Results TAPSE were correlated with global and regional measures of longitudinal LV function, segmental wall motion scores and measures of diastolic LV function as measured from transthoracic echocardiography. LV ejection fraction, wall motion index scores, atrio-ventricular annular plane systolic excursion of the mitral annulus were significantly related to TAPSE. Septal and posterior mitral annular plane systolic excursion (β = 0.56, p 2 = 0.28, p interaction = NS. Conclusion TAPSE is reduced with left ventricular dysfunction in heart failure patients, in particular with reduced septal longitudinal motion. TAPSE is decreased in patients with heart failure of ischemic etiology. However, the absolute reduction in TAPSE is small and seems to be of minor importance in the clinical utilization of TAPSE whether applied as a measure of right ventricular systolic function or as a prognostic factor.

  3. Predictors of right ventricular function as measured by tricuspid annular plane systolic excursion in heart failure

    DEFF Research Database (Denmark)

    Kjaergaard, Jesper; Iversen, Kasper K; Akkan, Dilek

    2009-01-01

    INTRODUCTION: Tricuspid Annular Plane Systolic Excursion (TAPSE) has independent prognostic value in heart failure patients but may be influenced by left ventricular (LV) ejection fraction. The present study assessed the association of TAPSE and clinical factors, global and regional LV function...... in 634 patients admitted for symptomatic heart failure. METHODS & RESULTS: TAPSE were correlated with global and regional measures of longitudinal LV function, segmental wall motion scores and measures of diastolic LV function as measured from transthoracic echocardiography.LV ejection fraction, wall...... failure (beta = 1.3, p = 0.002) were independent predictors of TAPSE, R(2) = 0.28, p failure etiology or any of the other clinical factors analyzed, P(interaction) = NS. CONCLUSION: TAPSE is reduced with left ventricular dysfunction...

  4. Tricuspid Annular Plane Systolic Excursion pada Bayi Kurang Bulan dan Cukup Bulan

    Directory of Open Access Journals (Sweden)

    Sri Endah Rahayuningsih

    2011-12-01

    Full Text Available A preterm infant is a baby born with gestational age less than 37 weeks. Preterm babies tend to have problems compared to normal ones. Premature gestational age might result in immaturity of all organ systems of the body including cardiovascular organs. The aim of this study was to find out the right ventricle function by tricuspid annular plane systolic excursion (TAPSE and left ventricle by ejection fraction and shortening fraction using echocardiography on preterm babies. The subject of this study were term and preterm babies who fulfilled the inclusion criteria: appropiate gestational age babies 3–30 days old. This was an analytic descriptive study with cross-sectional method held in Department of Child Health Dr. Hasan Sadikin Hospital Bandung during July–October 2010, and statistical analysis using t–test Spearman rank correlation test. The result of the study showed that the right ventricle function examined by TAPSE method was different on preterm compared to term babies (p=0.006. No significant difference was found in the ejection fraction between preterm and term babies (p=0.22 and so did the shortening fraction (p=0.20. It was concluded that there is a difference in the right ventricle function by TAPSE method between preterm (lower and term babies.

  5. Reference values of tricuspid annular peak systolic velocity in healthy pediatric patients, calculation of z score, and comparison to tricuspid annular plane systolic excursion.

    Science.gov (United States)

    Koestenberger, Martin; Nagel, Bert; Ravekes, William; Avian, Alexander; Heinzl, Bernd; Cvirn, Gerhard; Fritsch, Peter; Fandl, Andrea; Rehak, Thomas; Gamillscheg, Andreas

    2012-01-01

    The tricuspid annular peak systolic velocity (TAPSV) is an echocardiographic measurement assessing right ventricular systolic function in children and adults. We determined the growth-related changes of the TAPSV to establish the references values for the entire pediatric age group. A prospective study was conducted of a group of 860 healthy pediatric patients (age 1 day to 18 years; body surface area [BSA] 0.14 to 2.30 m(2)). We determined the effects of age, gender, and BSA on the TAPSV values. Stepwise linear multiple regression analysis was used to estimate the TAPSV from the age, BSA, and gender. A correlation of normal TAPSV with normal tricuspid annular plane systolic excursion values was performed. The TAPSV ranged from a mean of 7.2 cm/s (z score ± 2: 4.8 to 9.5 cm/s) in the newborn to 14.3 cm/s (z score ± 2: 10.6 to 18.6 cm/s) in the 18-year-old adolescent. The TAPSV values showed a positive correlation with age and BSA, with a nonlinear course. No significant difference was found in the TAPSV values according to gender. A significant correlation was found between the TAPSV and tricuspid annular plane systolic excursion values in our pediatric population. In conclusion, the z scores of the TAPSV values were calculated, and percentile charts were established to serve as reference data for patients with congenital heart disease.

  6. Right Ventricular Myocardial Tissue Velocities, Myocardial Performance Index, and Tricuspid Annular Plane Systolic Excursion in Totally Corrected Tetralogy of Fallot Patients

    Directory of Open Access Journals (Sweden)

    Asadolah Tanasan

    2015-10-01

    Full Text Available Background: Longer survival after the total repair of the Tetralogy of Fallot increases the importance of late complications such as right ventricular dysfunction. This is a prospective study of the right ventricular function in totally corrected Tetralogy of Fallot patients versus healthy children.Methods: Thirty-two healthy children were prospectively compared with 30 totally corrected Tetralogy of Fallot patients. Right ventricular myocardial tissue velocities, right ventricular myocardial performance index, and tricuspid annular plane systolic excursion were investigated as well as the presence and severity of pulmonary regurgitation.Results: The two groups were age-and sex-matched. Mean systolic peak velocity (Sa and tricuspid annular plane systolic excursion were significantly decreased, while myocardial performance index and early to late diastolic velocity (Ea/Aa were significantly increased in the Tetralogy of Fallot patients. Early diastolic velocity (Ea showed no significant difference between the two groups. Sa correlated significantly with tricuspid annular plane systolic excursion in both the normal children and totally corrected Tetralogy of Fallot patients. Myocardial performance index was significantly higher in the patients with moderate to severe pulmonary regurgitation than in those with mild regurgitation. However, there was no significant correlation between this index and right ventricular myocardial tissue velocities.Conclusion: In this study, systolic right ventricular function indices (Sa and tricuspid annular plane systolic excursion were impaired in the totally corrected Tetralogy of Fallot patients. Myocardial performance index was affected by the severity of pulmonary regurgitation.

  7. 超声心动图测量中晚孕正常胎儿瓣环位移差对评价胎儿心功能的研究%Value of annular plane systolic excursion difference in evaluation of heart systolic function of normal fetuses in ;the second and late trimester with echocardiography

    Institute of Scientific and Technical Information of China (English)

    郭显峰; 赵博文; 李益林

    2015-01-01

    目的:探讨胎儿二尖瓣环及三尖瓣环运动位移差值(瓣环位移差)对胎儿心功能定量研究的价值。方法选取455例孕20~41周正常胎儿,应用解剖 M 型超声心动图测量胎儿三尖瓣环位移(FAM-TAPSE)及二尖瓣环位移(FAM-MAPSE),并计算两者间差值。组织多普勒(TDI)分别测量二尖瓣环及三尖瓣环舒张早期峰值速度(Em 及 Em')和收缩期峰值速度(Sm 及 Sm')。随机选取中孕期及晚孕期共50例正常胎儿,采集标准四腔心观,输入 QLab 8.1工作站,分别选取右室游离壁三尖瓣环附着点、左室侧壁二尖瓣环附着点及心尖三点,同时获得二尖瓣环及三尖瓣环位移曲线图,比较二者位移曲线达峰时间的异同,并运用彩色追踪技术记录瓣环运动轨迹。结果各孕周 FAM-TAPSE 均大于 FAM-MAPSE,差异具有统计学意义(P 0.05)。结论瓣环位移差在胎儿中晚孕期持续存在,考虑与胎儿整体心室扭转有关,随孕周增加,瓣环位移差的增大还反映了胎儿心室扭转储备能力的增强。瓣环位移差能够定量反映胎儿心室整体的扭转及纵向运动,可作为评估胎儿心功能的另一新指标。%Objective To obtain the annular plane systolic excursion difference (APSED)of fetuses in second and late trimester by free angle M-mode (FAM)and tissue motion of annular displacement (TMAD)in order to assess the fetal ventricular function.Methods The mitral annular plane systolic excursion(MAPSE)and tricuspid annular plane systolic excursion(TAPSE)of four hundred and fifty five normal fetuses from 20 to 41 weeks were measured by FAM echocardiography,and the difference between them were calculated.Early diastolic velocities (Em)of the mitral annular and early diastolic velocities (Em')of the tricuspid annular were estimated by pulsed-wave tissue Doppler imaging (TDI),meanwhile systolic velocities (Sm)of the mitral annular and systolic velocities (Sm')of the tricuspid annular were also estimated

  8. M型超声心动图测量中晚孕正常胎儿三尖瓣环位移评价胎儿右心室功能%Tricuspid annular plane systolic excursion in evaluation of right heart systolic function of fetuses in second and late trimester with conventional M-mode and free angle M-mode echocardiography

    Institute of Scientific and Technical Information of China (English)

    郭显峰; 赵博文; 邱俊芬; 王蓓; 彭晓慧; 潘美

    2015-01-01

    Objective To evaluate the usefulness of free angle M-mode echocardiography (FAM) in obtaining tricuspid annular plane systolic excursion (TAPSE) for assessing the fetal right ventricular function,and to compare the results of measurements of TAPSE by conventional M-mode(CM) and FAM.Methods Two hundred and forty-three normal fetuses in second and late trimester were divided into 5 groups by gestational age(GA):20-24 weeks,24+1-28 weeks,28+1-32 weeks,32+1-36 weeks,36+1-40 weeks.The TAPSE were measured by CM and FAM echocardiography,meanwhile multiple parameters for evaluating right ventricular function were obtained by using myocardial tissue Doppler imaging (TDI),and the correlation between TAPSE and other parameters were analyzed by linear correlation.ANOVA was used to compare CM-TAPSE,FAM-TAPSE,Em,Sm and right ventricular fractional shortening(RVFS)with different GA.Regression equation estimate was used to compare the relationship of FAM-TAPSE with GA.Independent sample t test was used to compare CM TAPSE with FAM TAPSE.Results There were significant differences in CM-TAPSE,FAM-TAPSE,Em,and Sm among 5 groups (P =0.000),the measured value of FAM-TAPSE was higher than that of CM TAPSE (P =0.000).Both FAM-TPASE and CM-TAPSE showed significant positive correlations with GA,Em and Sm,but FAM TAPSE demonstrated better correlation than CM-TAPSE.Conclusions By adjusting sample line of FAM,measuring the maximum displacement of tricuspid annular plane is feasible,and FAM may evaluate fetal right ventricular function more accurately and effectively.%目的 应用解剖M型超声心动图(free angle M-mode,FAM)测量不同孕周胎儿三尖瓣环运动位移(tricuspid annular plane systolic excursion,TAPSE),探讨其评估右室功能的有效性并建立测值参考范围.方法 选取243例胎儿,根据不同孕周分成5组:20~24周,24+1~28周,28+1~32周,32+1~36周,36+1~40周,分别应用普通M型超声心动图(conventional M-mode,CM)及FAM测量胎儿TAPSE,

  9. Correlation between tricuspid annular plane systolic excursion and glomerular filtration rate in patients with acute decompensated heart failure%急性失代偿型心力衰竭患者三尖瓣收缩期位移与肾小球滤过率的关系

    Institute of Scientific and Technical Information of China (English)

    李邵琳; 张菲斐

    2016-01-01

    目的:探讨急性失代偿型心力衰竭患者三尖瓣收缩期位移(TAPSE)变化及其与肾小球滤过率的关系。方法选取慢性收缩性心力衰竭急性失代偿入院患者102例,经胸超声心动图检测TASPE、左室射血分数(LVEF)及肺动脉收缩压(PASP),静脉采血测定B型氨基端利钠肽原(NT- proBNP)、电解质、血尿素氮(BUN)及血肌酐,采用改良的MDRD方程计算肾小球滤过率(eGFR),将eGFR0.05)。在肾功能不全组中肾小球滤过率分别与TASPE、NT- proBNP、PASP、LVEF进行相关性分析,显示只有TASPE与肾小球滤过率呈显著相关(=0.62,%Objective To explore the change of tricuspid annular plane systolic excursion (TAPSE) and its corre-lation with glomerular filtration rate (GFR) in patients with acute decompensated heart failure (ADHF). Methods One hundred and two consecutive patients with acute decompensated heart failure and left ventricular ejection fraction (LVEF) below 50% on echocardiogram were enrolled. The value of TASPE, LVEF and pulmonary arterial systolic pressure (PASP) were measured by the transthoracic echocardiography. Blood test was conducted to determine NT-proBNP, electrolytes, BUN and creatinine. The estimated GFR (eGFR) was calculated on the basis of simplified Modification of Diet in Renal Disease (MDRD). According to the eGFR, the patients were divided into preserved re-nal function (PRF) group [eGFR≥60 ml/(min·1.73m2), =54] and renal dysfunction (RDSF) group [eGFR﹤60 ml/(min·1.73m2), = 48]. The echocardiographic parameters and serum indexes were compared between the two groups. The correlations between TASPE and echocardiographic parameters, serum indexes in the RDSF group were analyzed. Results TASPE in the PRF group [(16.4 ± 4.0) mm] was significantly lower than that in the RDSF group [(18.9 ± 3.8) mm, ﹤ 0.001], but no significant difference in NT-proBNP, PASP or LVEF was observed between the two groups ( ﹥ 0

  10. Z-score analysis of tricuspid annular plane systolic excursion in normal fetuses with fetal echocardiography%超声心动图建立正常胎儿三尖瓣环位移Z评分数据模型的研究

    Institute of Scientific and Technical Information of China (English)

    郭显峰; 赵博文; 李益林

    2015-01-01

    目的 探讨正常胎儿三尖瓣环位移(TAPSE)与其生物学生长参数的相互关系,从而定量TAPSE的Z评分实际参考范围.方法 应用超声心动图对1012例孕龄为19~41周的胎儿进行检测,获得胎儿的双顶径(BPD)、股骨长径(FL)等正常胎儿的生长参数,并根据停经史计算胎儿的孕周(GA),通过解剖M型超声心动图技术测量TAPSE.以GA、BPD及FL作为自变量,TAPSE作为因变量建立最佳模型,再分析标准差(SD)与自变量BPD、FL及GA的相关关系,通过以上统计数据,运用公式计算得到Z评分的参考范围.结果 统计分析显示,直线回归方程能够很好地反映胎儿非心血管参数BPD、FL、GA与心脏功能参数TAPSE之间的相关性.SD随自变量增大而增大,也呈线性关系,运用绝对残差的加权回归消除SD的异方差性,建立直线回归模型,根据这些方程,TAPSE的Z评分值=(实际测量的TAPSE-预测的TAPSE)/预测TAPSE的SD.结论 运用统计学方法,建立了通过胎儿GA、BPD、FL计算TAPSE的Z评分正常参考范围,为胎儿右心功能的评估提供了更加精准的参考标准.%Objective To develop Z-score reference ranges for tricuspid annular plane systolic excursion(TAPSE) in normal fetuses from the measurements of gestational age(GA),biparietal diameter (BPD) or femur length(FL) using fetal echocardiography.Methods A retrospective cross sectional study of 1012 singleton normal fetuses were performed.The gestation age ranged from 20 to 41 weeks.Non-cardiac fetal biometric parameters included GA and BPD and FL were measured and calculated GA based on menstrual age.TAPSE was measured in a standard apical four-chamber view by free angle M-mode echocardiography.Normal Z-score ranges were developed for TAPSE using GA,BPD and FL as independent variables.These were accomplished by using first standard regression analysis and then weighted regression of absolute residual values for each parameter in order to adjust for

  11. Evaluation of Right Ventricular Volume and Systolic Function by Real-time Three-dimensional Echocardiography

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    WANG Jing; WANG Xinfang; XIE Mingxing; YANG Ya; LV Qing; YANG Ying; WANG Liangyu

    2005-01-01

    The optimal plane for measurement of the right ventricular (RV) volumes by real-time three-dimensional echocardiography (RT3DE) was determined and the feasibility and accuracy of RT3DE in studying RV systolic function was assessed. RV "Full volume" images were acquired by RT3DE in 22 healthy subjects. RV end-diastolic volumes (RVEDV) and end-systolic volumes (RVESV) were outlined using apical biplane, 4-plane, 8-plane, 16-plane offline separately. RVSV and RVEF were calculated. Meanwhile tricuspid annual systolic excursion (TASE) was measured by M-mode echo. LVSV was outlined by 2-D echo according to the biplane Simpsons rule. The results showed: (1) There was a good correlation between RVSV measured from series planes and LVSV from 2-D echo (r=0.73; r=0.69; r=0.63; r=0.66, P<0.25-0. 0025); (2) There were significant differences between RVEDV in biplane and those in 4-, 8-, 16-plane (P<0. 001). There was also difference between RV volume in 4-plane and that in 8-plane (P<0.05), but there was no significant difference between RV volume in 8-plane and that in 16-plane (P>0.05); (3) Inter-observers and intro-observers variability analysis showed that there were close agreements and relations for RV volumes (r=0. 986, P<0. 001; r=0.93, P<0. 001); (4) There was a significantly positive correlation of TASE to RVSV and RVEF from RT3DE (r=0.83; r=0.90). So RV volume measures with RT3DE are rapid, accurate and reproducible. In view of RVs complex shape,apical 8-plane method is better in clinical use. It may allow early detection of RV systolic function.

  12. Cruise tourism shore excursions

    DEFF Research Database (Denmark)

    João Lopes, Maria; Dredge, Dianne

    2017-01-01

    Very complex yet highly integrated business logics characterise cruise tourism with shore excursions frequently identified as a key source of value. This paper presents a case study of cruise tourism and shore excursion planning in Copenhagen, Denmark. The aim of this paper is to investigate...... the characteristics of cruise tourism, itinerary and shore excursion planning with a view to understanding the value generated from cruise tourism shore excursions. We argue that economic value is a blunt measure, and there are other types of value, positive and negative, that are also generated. This research...... reveals that a range of local conditions and structural characteristics create barriers and opportunities for generating different types of value. Using a case study of shore excursions in Copenhagen, the Baltic’s most important port, this paper explains the dynamics between cruise tourism and shore...

  13. Mono Lake Excursion Reviewed

    Science.gov (United States)

    Liddicoat, J. C.; Coe, R. S.

    2007-05-01

    The Mono Lake Excursion as recorded in the Mono Basin, CA, has an older part that is about negative 30 degrees inclination and about 300 degrees declination during low relative field intensity. Those paleomagnetic directions are closely followed by greater than 80 degrees positive inclination and east declination of about 100 degrees during higher relative field intensity. A path of the Virtual Geomagnetic Poles (VGPs) for the older part followed from old to young forms a large clockwise loop that reaches 35 degrees N latitude and is centered at about 35 degrees E longitude. That loop is followed by a smaller one that is counterclockwise and centered at about 70 degrees N latitude and 270 degrees E longitude (Denham & Cox, 1971; Denham, 1974; Liddicoat & Coe, 1979). The Mono Lake Excursion outside the Mono Basin in western North America is recorded as nearly the full excursion at Summer Lake, OR (Negrini et al., 1984), and as the younger portion of steep positive inclination/east declination in the Lahontan Basin, NV. The overall relative field intensity during the Mono Lake Excursion in the Lahontan Basin mirrors very closely the relative field intensity in the Mono Basin (Liddicoat, 1992, 1996; Coe & Liddicoat, 1994). Using 14C and 40Ar/39Ar dates (Kent et al., 2002) and paleoclimate and relative paleointensity records (Zimmerman et al., 2006) for the Mono Lake Excursion in the Mono Basin, it has been proposed that the Mono Lake Excursion might be older than originally believed and instead be the Laschamp Excursion at about 40,000 yrs B.P. (Guillou et al., 2004). On the contrary, we favor a younger age for the Mono Lake Excursion, about 32,000 yrs B.P., using the relative paleointensity in the Mono Basin and Lahontan Basin and 14C dates from the Lahontan Basin (Benson et al., 2002). The age of about 32,000 yrs B.P. is also in accord with the age (32,000- 34,000 yrs B.P.) reported by Channell (2006) for the Mono Lake Excursion at ODP Site 919 in the Irminger Basin

  14. Excursion recommendation system

    OpenAIRE

    Pompe, Grega

    2011-01-01

    Purpose of this thesis was to develop a system, which automatically suggests suitable excursion on base of users location and marks with minimal user load. There are websites with long lists of different excursions, which demand the user to at least briefly know what they want. Application was developed in programing language PHP in conjunction with MySQL database. Ranking system is based on general marks, which are result of positive and negative feedback from users, distance between user an...

  15. Early right ventricular systolic dysfunction in patients with systemic sclerosis without pulmonary hypertension: a Doppler Tissue and Speckle Tracking echocardiography study

    Directory of Open Access Journals (Sweden)

    Baumann Gert

    2010-01-01

    Full Text Available Abstract Background Isovolumetric acceleration (IVA is a novel tissue Doppler parameter for the assessment of systolic function. The aim of this study was to evaluate IVA as an early parameter for the detection of right ventricular (RV systolic dysfunction in patients with systemic sclerosis (SSc without pulmonary hypertension. Methods 22 patients and 22 gender- and age-matched healthy subjects underwent standard echocardiography with tissue Doppler imaging (TDI and speckle tracking strain to assess RV function. Results Tricuspid annular plane systolic excursion (TAPSE (23.2 ± 4.1 mm vs. 26.5 ± 2.9 mm, p 2 vs. 4.1 ± 0.8 m/s2, p Conclusion IVA is a useful tool with high-predictive power to detect early right ventricular systolic impairment in patients with SSc and without pulmonary hypertension.

  16. Right Ventricular Systolic Dysfunction in Chagas Disease Defined by Speckle-Tracking Echocardiography: A Comparative Study with Cardiac Magnetic Resonance Imaging.

    Science.gov (United States)

    Moreira, Henrique T; Volpe, Gustavo J; Marin-Neto, José A; Nwabuo, Chike C; Ambale-Venkatesh, Bharath; Gali, Luis G; Almeida-Filho, Oswaldo C; Romano, Minna M D; Pazin-Filho, Antonio; Maciel, Benedito C; Lima, João A C; Schmidt, André

    2017-05-01

    Chagas disease leads to biventricular heart failure, usually with prominent systemic congestion. Although echocardiography is widely used in clinical routine, the utility of echocardiographic parameters to detect right ventricular (RV) systolic dysfunction in patients with Chagas disease is unknown. We sought to study the diagnostic value of echocardiography, including speckle-tracking parameters, to distinguish individuals with RV systolic dysfunction from those with normal RV systolic function in Chagas disease using cardiac magnetic resonance (CMR) as the reference method. In this cross-sectional study, 63 individuals with Chagas disease underwent echocardiography and CMR evaluations. Conventional echocardiographic parameters for RV functional evaluation were tricuspid annular plane systolic excursion, RV systolic excursion velocity, fractional area change, and RV index of myocardial performance. Strain and strain rate were obtained by two-dimensional speckle-tracking echocardiography and defined as "RV free wall," when based only in segments from RV free wall, or "RV free wall and septum," when segments from both free RV wall and interventricular septum were included. RV systolic dysfunction was defined as RV ejection fraction (RVEF) -22.5% for men and >-23.3% for women) exhibited the highest area under the receiver operating characteristic curve (area under the curve = 0.829) to differentiate the presence from the absence of RV systolic dysfunction in Chagas disease, with a sensitivity and specificity of 67% and 83%, respectively. RV free wall strain is an appropriate and superior echocardiographic variable for evaluating RV systolic function in Chagas disease, and it should be the method of choice for this purpose. Copyright © 2017 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved.

  17. Interobserver agreement on the echocardiographic parameters that estimate right ventricular systolic function in the early postoperative period of cardiac surgery.

    Science.gov (United States)

    Olmos-Temois, S G; Santos-Martínez, L E; Álvarez-Álvarez, R; Gutiérrez-Delgado, L G; Baranda-Tovar, F M

    2016-11-01

    To know the variability of transthoracic echocardiographic parameters that assess right ventricular systolic function by analyzing interobserver agreement in the early postoperative period of cardiovascular surgery. To assess the feasibility of these echocardiographic measurements. A cross-sectional study, double-blind pilot study was carried out from May 2011 to February 2013. Cardiovascular postoperative critical care at the National Institute of Cardiology "Ignacio Chávez", Mexico City, Mexico. Consecutive, non-probabilistic sampling. Fifty-six patients were studied in the postoperative period of cardiac surgery. The first echocardiographic parameters were obtained between 6-8hours after cardiac surgery, followed by blinded second measurements. Tricuspid annular plane systolic excursion (TAPSE), tricuspid annular peak systolic velocity on tissue Doppler imaging (VSPAT), diameters and right ventricular outflow area, tract fractional shortening. The agreement was analyzed by the Bland-Altman method, and its magnitude was assessed by the intraclass correlation coefficient (95% confidence interval). Both observers evaluated TAPSE and VSPAT in 48 patients (92%). The average TAPSE was 11.68±4.53mm (range 4-27mm). Right ventricular systolic dysfunction was observed in 41 cases (85%) and normal TAPSE in 7 patients (15%). The average difference and its limits according to TAPSE were -0.917±2.95 (-6.821, 4.988), with a magnitude of 0.725 (0.552, 0.837); the tricuspid annular peak systolic velocity on tissue Doppler imaging was -0.001±0.015 (-0.031, 0.030), and its magnitude 0.825 (0.708, 0.898), respectively. VSPAT and TAPSE were estimated by both observers in 92% of the patients, these parameters exhibiting the lowest interobserver variability. Copyright © 2016 Elsevier España, S.L.U. y SEMICYUC. All rights reserved.

  18. V-plane显像与组织多普勒技术评价扩张型心肌病患者左心室收缩同步性的一致性研究%Evaluation of consistency between V-plane imaging and tissue Doppler imaging for systolic synchronicity in patients with dilated cardiomyopathy

    Institute of Scientific and Technical Information of China (English)

    宋宏宁; 周青; 秦真英; 陈金玲; 郭瑞强

    2014-01-01

    目的 应用V-plane技术观察扩张型心肌病(DCM)患者左心室收缩不同步显像,并与临床常用的组织多普勒显像(TDI)技术进行对比,评价其相关性与一致性.方法 对20例DCM患者及20例健康对照者进行超声检查,获取二维图像、V-plane双平面图像和TDI图像,测量左室12个节段TDI脉冲频谱达峰时间,并计算其标准差(TDI_SD),测量V-plane显像中12节段收缩位移达峰时间,并计算其标准差(V-plane_SD).结果 与对照组相比,DCM组的TDI SD和V-plane_SD增大,TDI达峰时间延迟,V-plane达峰时间缩短,差异有统计学意义(P<0.01);DCM组与对照组12节段中各节段V-plane收缩达峰时间均显著高于TDI收缩达峰时间,差异有统计学意义(P<0.01);V-plane_SD与TDI_SD具有显著相关性(r=0.925,P<0.001),Bland-Ahman分析显示TDI SD与V-plane_SD比值的95%数据点在一致性界限内,其比值的一致性界限为(0.50,1.36).结论 在评价DCM患者左室收缩同步性时V-plane技术与TDI技术具有较高的相关性及一致性,V-plane能克服TDI不能在同一心动周期显示12节段的局限性.%Objective To evaluate left ventricular systolic synchronicity in patients with dilated cardiomyopathy by V-plane imaging and compare with clinical commonly used tissue Doppler imaging (TDI),evaluate the relevance and consistency between these two parameters.Methods 20 patients diagnosed with DCM and 20 healthy controls were enrolled,2D images,V-plane imaging and TDI waveform were acquired.Time to peak velocity of left ventricular 12 segments were measured by TDI and the standard deviation (TDI_SD) were calculated.Displacement time to peak were measured by V-plane and the standard deviation (V-plane_SD) were calculated.Results Compared with control group,TDI_SD and V-plane_SD increased significantly (P < 0.01),TDI time to peak increased and V-plane time to peak decreased significantly(P <0.01).In the two group,12 segment time to peak measured by V-plane

  19. Scalar excursions in large-eddy simulations

    Science.gov (United States)

    Matheou, Georgios; Dimotakis, Paul E.

    2016-12-01

    The range of values of scalar fields in turbulent flows is bounded by their boundary values, for passive scalars, and by a combination of boundary values, reaction rates, phase changes, etc., for active scalars. The current investigation focuses on the local conservation of passive scalar concentration fields and the ability of the large-eddy simulation (LES) method to observe the boundedness of passive scalar concentrations. In practice, as a result of numerical artifacts, this fundamental constraint is often violated with scalars exhibiting unphysical excursions. The present study characterizes passive-scalar excursions in LES of a shear flow and examines methods for diagnosis and assesment of the problem. The analysis of scalar-excursion statistics provides support of the main hypothesis of the current study that unphysical scalar excursions in LES result from dispersive errors of the convection-term discretization where the subgrid-scale model (SGS) provides insufficient dissipation to produce a sufficiently smooth scalar field. In the LES runs three parameters are varied: the discretization of the convection terms, the SGS model, and grid resolution. Unphysical scalar excursions decrease as the order of accuracy of non-dissipative schemes is increased, but the improvement rate decreases with increasing order of accuracy. Two SGS models are examined, the stretched-vortex and a constant-coefficient Smagorinsky. Scalar excursions strongly depend on the SGS model. The excursions are significantly reduced when the characteristic SGS scale is set to double the grid spacing in runs with the stretched-vortex model. The maximum excursion and volume fraction of excursions outside boundary values show opposite trends with respect to resolution. The maximum unphysical excursions increase as resolution increases, whereas the volume fraction decreases. The reason for the increase in the maximum excursion is statistical and traceable to the number of grid points (sample size

  20. Additive functionals and excursions of Kuznetsov processes

    Directory of Open Access Journals (Sweden)

    Hacène Boutabia

    2005-01-01

    semigroup of transition. In this paper, we give the excursion laws of (Xtt∈ℝ+ conditioned on the strict past and future without duality hypothesis. We study excursions of a general regenerative system and of a regenerative system consisting of the closure of the set of times the regular points of B are visited. In both cases, those conditioned excursion laws depend only on two points Xg− and Xd, where ]g,d[ is an excursion interval of the regenerative set M. We use the (FDt-predictable exit system to bring together the isolated points of M and its perfect part and replace the classical optional exit system. This has been a subject in literature before (e.g., Kaspi (1988 under the classical duality hypothesis. We define an “additive functional” for (Ytt∈ℝ with B, we generalize the laws cited before to (Ytt∈ℝ, and we express laws of pairs of excursions.

  1. 22. Comparison of conventional echocardiographic parameters of rv systolic function with cardiac magnetic resonance imaging

    Directory of Open Access Journals (Sweden)

    H. Shamsan

    2016-07-01

    Full Text Available Nowadays, cardiac magnetic resonance (CMR imaging is considered the gold standard for quantification of RV size and function. Multiple 2D Echocardiography (echo parameters are recommended for quantification of systolic RV function including Fractional Area Change (FAC%, tricuspid annular plane systolic excursion (TAPSE and Tissue Doppler velocity (TDI of tricuspid annulus. The aim of our study was to compare the conventional 2-D echocardiographic parameters of RV systolic function with CMR derived RVEF and stroke volume (SV. The echo and cardiac magnetic parameters to assess the right ventricular function are different. Consecutive patients referred to CMR for RV assessment from January 2011 to December 2014 were screened. 69 patients with CMR and adequate echo were selected. 20 subjects with normal CMR were enrolled as a control group. Quantitative 2-D echo measures were compared with CMR RVEF (% and SV (ml. The comparison was made using linear correlation for the echo variables with CMR variables. The mean age of patients was 38.2 + 5.4 (51% females were enrolled. 84.1% of patients had normal RVEF by CMR. In patients, FAC% but not TAPSE or annular TDI, correlated with CMR derived RVEF (R = 0.45, p = 0.0001 with fair agreement (kappa 0.43. However, FAC% did not correlate with CMR RV stroke volume. In contrast, in normal subjects, TAPSE had the best correlation with CMR derived RVEF (R = 0.67, p = 0.0001. In patients, CMR reclassified RV function assessed by FAC% in 11 (16%. 6 (8% patients who had abnormal RV function by FAC% were reclassified as normal while 5 (7% with normal RV function by FAC% were reclassified as abnormal. In normal subjects, however, only one with abnormal RV function by TAPSE was reclassified as normal by CMR. The current quantitative 2-D echo parameters of RV systolic function assessment correlate poorly with CMR measured RVEF and SV and behave differently in comparison with CMR in patients with normal and

  2. Autonomous excursions using tablets and smartphones

    Science.gov (United States)

    Marra, Wouter; Groothengel, Marin; van de Grint, Liesbeth; Karssenberg, Derek; Stouthamer, Esther

    2017-04-01

    Excursions and fieldworks are valuable components for geosciences education. However, field activities can be time consuming for teachers and pose a logistical challenge to fit in regular courses. Furthermore, the participation of students diminishes with group size in case of instructor-led outings. We are developing excursions that students can follow autonomously without a teacher present, using instructions, assignments and background information on tablets and smartphones. The goal of this approach is to increase the level of active participation, and to reduce logistical and time table issues. We developed a bike-excursion about the landscape and geology in the vicinity of our University. Such excursion was on the wish-list for several years, but posed a logistical challenge for the group of about 80 students in the available timeslot. In our approach, students had a time-window of two weeks in which they could finish the excursion in groups of 2. 8-Inch tablets with water- and shock-proof cases were available for this excursion. For the excursion we used three apps: 1) IZI-Travel for providing the route, spoken navigation instructions, spoken explanations at stops, location-related images, assignments as text, and multiple-choose questions. 2) PDF-Maps for providing geo-referenced maps. 3) ESRI Collector which the students used to digitize polygons on a map, and to collect geo-referenced photos with explanation. These data were answers to assignments and were later used in a tutorial on campus. The assignments where students had to collect data, and the small group size (pairs) increased the level of active participation. The use of a final tutorial on campus was important for the autonomous excursion, as it gave students the opportunity to discuss their observations and questions with their teacher. The developed teaching materials are available online to use and adapt for others. Parts could be useful for other universities and schools in the vicinity of

  3. Theoretical foundations of organizing student excursions

    Directory of Open Access Journals (Sweden)

    Anđelković Sonja

    2012-01-01

    Full Text Available Once the cornerstone of sciences, student excursions have become adventurous social events, the value of which should be reconsidered. Since recommendations for organization of student excursions are mostly based on research findings and practitioners’ experiences, we have attempted to base them on the assumptions of contemporary theories of development, learning and motivation. Potential recommendations for organization of quality student excursions are derived from the constructivist theory of cognitive development, experiential learning theory and self-determination theory. The main recommendations refer to: establishing the link between excursions and the curriculum; a student-centred approach; students’ autonomy in planning and organizing excursions; promoting research activities in students; promoting joint activities of students and teachers, as well as joint activities of students, and authentic experiences in the out-of-school context. Recommendations are grouped into five categories: integrating excursions in the curriculum; motivating students; structure and authenticity of activities; encouraging students to think; social interaction during excursions. Research findings indicate that there is a gap between theory and practice of organizing students excursions. This situation is mostly explained by logistic and system shortcomings. We therefore suggest a more serious discussion of the place of excursions in the curriculum, financial support to their organization and reinforcing teachers to implement this form of teaching. [Projekat Ministarstva nauke Republike Srbije, br. 179034: Od podsticanja inicijative, saradnje, stvaralaštva u obrazovanju do novih uloga i identiteta u društvu i br. 47008: Unapređivanje kvaliteta i dostupnosti obrazovanja u procesima modernizacije Srbije

  4. The Asymmetric Exclusion Process and Brownian Excursions

    Science.gov (United States)

    Derrida, B.; Enaud, C.; Lebowitz, J. L.

    2004-04-01

    We consider the totally asymmetric exclusion process (TASEP) in one dimension in its maximal current phase. We show, by an exact calculation, that the non-Gaussian part of the fluctuations of density can be described in terms of the statistical properties of a Brownian excursion. Numerical simulations indicate that the description in terms of a Brownian excursion remains valid for more general one dimensional driven systems in their maximal current phase.

  5. Transesophageal Speckle-Tracking Echocardiography Improves Right Ventricular Systolic Function Assessment in the Perioperative Setting.

    Science.gov (United States)

    Markin, Nicholas W; Chamsi-Pasha, Mohammed; Luo, Jiangtao; Thomas, Walker R; Brakke, Tara R; Porter, Thomas R; Shillcutt, Sasha K

    2017-02-01

    Perioperative evaluation of right ventricular (RV) systolic function is important to follow intraoperative changes, but it is often not possible to assess with transthoracic echocardiographic (TTE) imaging, because of surgical field constraints. Echocardiographic RV quantification is most commonly performed using tricuspid annular plane systolic excursion (TAPSE), but it is not clear whether this method works with transesophageal echocardiographic (TEE) imaging. This study was performed to evaluate the relationship between TTE and TEE TAPSE distances measured with M-mode imaging and in comparison with speckle-tracking TTE and TEE measurements. Prospective observational TTE and TEE imaging was performed during elective cardiac surgical procedures in 100 subjects. Speckle-tracking echocardiographic TAPSE distances were determined and compared with the TTE M-mode TAPSE standard. Both an experienced and an inexperienced user of the speckle-tracking echocardiographic software evaluated the images, to enable interobserver assessment in 84 subjects. The comparison between TTE M-mode TAPSE and TEE M-mode TAPSE demonstrated significant variability, with a Spearman correlation of 0.5 and a mean variance in measurement of 6.5 mm. There was equivalence within data pairs and correlations between TTE M-mode TAPSE and both speckle-tracking TTE and speckle-tracking TEE TAPSE, with Spearman correlations of 0.65 and 0.65, respectively. The average variance in measurement was 0.6 mm for speckle-tracking TTE TAPSE and 1.5 mm for speckle-tracking TEE TAPSE. Using TTE M-mode TAPSE as a control, TEE M-mode TAPSE results are not accurate and should not be used clinically to evaluate RV systolic function. The relationship between speckle-tracking echocardiographic TAPSE and TTE M-mode TAPSE suggests that in the perioperative setting, speckle-tracking TEE TAPSE might be used to quantitatively evaluate RV systolic function in the absence of TTE imaging. Copyright © 2016 American Society

  6. Analyzing flow anisotropies with excursion sets in relativistic heavy-ion collisions

    CERN Document Server

    Mohapatra, Ranjita K; Srivastava, Ajit M

    2011-01-01

    We show that flow anisotropies in relativistic heavy-ion collisions can be analyzed using a certain technique of shape analysis of excursion sets recently proposed by us for CMBR fluctuations to investigate anisotropic expansion history of the universe. The technique analyzes shapes (sizes) of patches above (below) certain threshold value for transverse energy/particle number (the excursion sets) as a function of the azimuthal angle and rapidity. Modeling flow by imparting extra anisotropic momentum to the momentum distribution of particles from HIJING, we compare the resulting distributions for excursion sets at two different azimuthal angles. Angles with maximum difference in the two distributions identify the event plane, and the magnitude of difference in the two distributions relates to the magnitude of momentum anisotropy, i.e. elliptic flow.

  7. [Effects of articulating paper on mandibular paths in lateral and protrusive excursions].

    Science.gov (United States)

    Mori, T; Kawaguchi, T; Katto, K; Kano, N; Takeuchi, K; Tanaka, K; Usami, H; Naka, Y; Asakura, Y

    1989-12-01

    Mandibular movements in 7 normal dentulous subjects during lateral and protrusive excursions were studied to investigate the effects of the clinical use of articulating paper on mandibular paths. Mandibular movements with or without the intraoral articulating paper (thickness: 35 microns) were detected as the lower incisal point displacement and were recorded three-dimensionally with the Selspot system. The date displayed on the X-Y chart recorder on the selected plane were analyzed quantitatively. 1. The paths of the mandible differed between the outward (from the intercuspal position) and the return (backward to the intercuspal position) movements. In lateral excursions the return path tended to be antero-inferior to the outward path, whereas in protrusive excursions the former tended to be dextro-inferior to the latter. 2. In lateral excursions the return path tended to be less stable than the outward path. In protrusive excursions no significant difference was found between the two paths. 3. In lateral excursions, 21-34% of the movements performed using the articulating paper deviated from the normal paths made without using the paper, and in the case of protrusive excursions, deviation was found in 21-50%. At or near the intercuspal position, the return path showed a greater deviation than the outward path. Near the edge-to-edge position, however, the relationship between these two path was reversed. 4. It is suggested that, when the articulating paper is used, the directions of the movement should be taken into account and sufficient care should be paid in occlusal adjustment because the range of functional movement may be overestimated.

  8. Clericalization of the Russian Excursion Tourism

    Directory of Open Access Journals (Sweden)

    Boris Rodoman

    2014-05-01

    Full Text Available In the modern Russia almost every secular excursion is starting to resemble a religious pilgrimage, while reducing itself to a visit to Orthodox monasteries and temples. A lot of stories are told about saints and their actions, an unconcealed religious propaganda is carried on, and the history of the country is presented in a cleric-monarchical manner.

  9. Excursion-Set-Mediated Genetic Algorithm

    Science.gov (United States)

    Noever, David; Baskaran, Subbiah

    1995-01-01

    Excursion-set-mediated genetic algorithm (ESMGA) is embodiment of method of searching for and optimizing computerized mathematical models. Incorporates powerful search and optimization techniques based on concepts analogous to natural selection and laws of genetics. In comparison with other genetic algorithms, this one achieves stronger condition for implicit parallelism. Includes three stages of operations in each cycle, analogous to biological generation.

  10. Excursion-Set-Mediated Genetic Algorithm

    Science.gov (United States)

    Noever, David; Baskaran, Subbiah

    1995-01-01

    Excursion-set-mediated genetic algorithm (ESMGA) is embodiment of method of searching for and optimizing computerized mathematical models. Incorporates powerful search and optimization techniques based on concepts analogous to natural selection and laws of genetics. In comparison with other genetic algorithms, this one achieves stronger condition for implicit parallelism. Includes three stages of operations in each cycle, analogous to biological generation.

  11. 46 CFR 115.204 - Permit to carry excursion party.

    Science.gov (United States)

    2010-10-01

    ... issued an excursion permit will normally be required to meet the minimum stability, survival craft, life jacket, fire safety, and manning standards applicable to a vessel in the service for which the excursion...

  12. ORNITHOLOGICAL EXCURSIONS IN MURMANSK: GEOINFORMATION ASPECT

    Directory of Open Access Journals (Sweden)

    M. N. Kharlamova

    2014-01-01

    Full Text Available The method to use efficiently GIS-technologies in arranging the field practice of students on ornithology has been proposed. The ornithological excursions were performed in surroundings of the City of Murmansk in the conditions of weakly urbanized landscape. Using the facilities of freely distributed cartographic «SAS-Planet» software a simple GIS was formed in its environment where to the data on bird nest location with their description, the information about the route nodal points, water body crossing, stay places and others were put down. The mentioned data were obtained as a result of preliminary field research with the aid of satellite navigator including accumulating and summing up the information for a number of previous similar investigations. As a result, a final route in the current year was developed using which during the field practice the ornithological excursions were arranged.

  13. Excursion set peaks: the role of shear

    CERN Document Server

    Castorina, Emanuele; Hahn, Oliver; Sheth, Ravi K

    2016-01-01

    Recent analytical work on the modelling of dark halo abundances and clustering has demonstrated the advantages of combining the excursion set approach with peaks theory. We extend these ideas and introduce a model of excursion set peaks that incorporates the role of initial tidal effects or shear in determining the gravitational collapse of dark haloes. The model -- in which the critical density threshold for collapse depends on the tidal influences acting on protohaloes -- is well motivated from ellipsoidal collapse arguments and is also simple enough to be analytically tractable. We show that the predictions of this model are in very good agreement with measurements of the halo mass function and traditional scale dependent halo bias in N-body simulations across a wide range of masses and redshift. The presence of shear in the collapse threshold means that halo bias is naturally predicted to be nonlocal, and that protohalo densities at fixed mass are naturally predicted to have Lognormal-like distributions. ...

  14. Practices and Methods for Actualization of the Scientific Information in Art Excursions (Excursions and Cultural Heritage in the Contemporary World)

    Science.gov (United States)

    Portnova, Tatiana V.

    2016-01-01

    The paper deals with various practices and methods for actualization of the scientific information in art excursions. The modern society is characterized by commitment to information richness. The range of cultural and historical materials used as the basis for art excursions is really immense. However if to consider the number of excursions with…

  15. Educational Excursions in Technical Schools of Pre-revolutionary Russia

    Directory of Open Access Journals (Sweden)

    Timur A. Magsumov

    2013-01-01

    Full Text Available The author, using the data of pre-revolutionary technical schools, traces the genesis and trends of educational excursions development in the Russian Empire. Special attention is attached to the types, organizational forms and methods of excursion activities, educational policy, concerning its development. The article presents author’s classification of educational excursions, notes that educational excursions have become traditional and were operated systematically by the early XX century. Field excursions, which in fact displaced introductive training, prevailed in technical schools

  16. Synthetic and sedimentary records of geomagnetic excursions

    Science.gov (United States)

    Vlag, P.; Thouveny, N.; Rochette, P.

    The geomagnetic excursion recorded in the sediments of Lac St.Front (Massif Central, France) is characterized by shallow and negative inclinations followed by a younger steep inclination interval (Vlag et al., 1996). In the corresponding interval of the nearby Lac du Bouchet only steep inclinations are found. Sedimentary records of the Mono Lake excursion show similar inclination patterns; ‘complete’ records of this excursion show a succession of a shallow by a steep inclination interval, while ‘incomplete’ records only show only steep inclinations (Coe and Liddicoat, 1994). Due to a non-instantaneous acquisition of the remanence, sedimentary records reflect only a smoothed geomagnetic signal. It will be shown that smoothing of a small low-intensity ‘reversed’ interval embedded in a non-antipodal normal field interval may result in records of a shallow inclination interval followed by a steep inclination interval, while further smoothing results in only steep inclinations. Realignment of magnetic grains by the stronger normal field can also produce such records and may explain why such an unusual large lock-in depth is required by the conventional smoothing model. Whatever the mechanism, the similarities between these synthetic records and the excursional records of Lac St. Front-Lac du Bouchet and Mono Lake suggest that the latter are more or less affected by vector addition of two non-antipodal directions.

  17. Virtual reality excursions with programs in C

    CERN Document Server

    Watkins, Christopher D

    1994-01-01

    Virtual Reality Excursions with Programs in C provides the history, theory, principles and an account of the milestones in the development of virtual reality technology.The book is organized into five chapters. The first chapter explores the applications in the vast field of virtual reality. The second chapter presents a brief history of the field and its founders. Chapter 3 discusses human perception and how it works. Some interesting notes and much of the hot debate in the field are covered in Chapter 4. The fifth chapter describes many of the complexities involved in implementing virtual en

  18. Systolic implementation of neural networks

    Energy Technology Data Exchange (ETDEWEB)

    De Groot, A.J.; Parker, S.R.

    1989-01-01

    The backpropagation algorithm for error gradient calculations in multilayer, feed-forward neural networks is derived in matrix form involving inner and outer products. It is demonstrated that these calculations can be carried out efficiently using systolic processing techniques, particularly using the SPRINT, a 64-element systolic processor developed at Lawrence Livermore National Laboratory. This machine contains one million synapses, and forward-propagates 12 million connections per second, using 100 watts of power. When executing the algorithm, each SPRINT processor performs useful work 97% of the time. The theory and applications are confirmed by some nontrivial examples involving seismic signal recognition. 4 refs., 7 figs.

  19. Automatic backscatter analysis of regional left ventricular systolic function using color kinesis.

    Science.gov (United States)

    Schwartz, S L; Cao, Q L; Vannan, M A; Pandian, N G

    1996-06-15

    Assessment of regional wall motion by 2-dimensional echocardiography can be performed by either semiquantitative wall motion scoring or by quantitative analysis. The former is subjective and requires expertise. Quantitative methods are too time-consuming for routine use in a busy clinical laboratory. Color kinesis is a new algorithm utilizing acoustic backscatter analysis. It provides a color encoded map of endocardial motion in real time. In each frame a new color layer is added; the thickness of the color beam represents endocardial motion during that frame. The end-systolic image has multiple color layers, representing regional and temporal heterogeneity of segmental motion. The purpose of this study was to validate the use of color kinesis for semiquantitative analysis of regional left ventricular systolic function and quantitatively in measurement of endocardial excursion. Semiquantitative wall motion scoring was performed in 18 patients using both 2-dimensional echo and color kinesis. Scoring was identical in 74% of segments; there was 84% agreement in definition of normal vs. abnormal. There was less interobserver variability in wall motion scoring using color kinesis. Endocardial excursion was quantified in 21 patients. 70% of the imaged segments were suitable for analysis. Correlation between 2-dimensional echocardiographic measurements and color kinesis was excellent, r = 0.87. The mean difference in excursion as measured by the 2 methods was -0.05 +/- 2.0 mm. In conclusion, color kinesis is a useful method for assessing regional contraction by displaying a color map of systolic endocardial excursion. This algorithm may improve the confidence and accuracy of assessment of segmental ventricular function by echocardiographic methods.

  20. Simulation of power excursions - Osiris reactor; Simulation des excursions de puissance - pile Osiris

    Energy Technology Data Exchange (ETDEWEB)

    Pascouet, A. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-07-01

    Following the experimental work accomplished in the U.S.A. on Borax 1 and SPERT 1 and the accident of SL 1, the 'Commissariat a l'Energie Atomique' started a research program about the safety of its own swimming Pool reactors, with regard to power excursions. The first research work led to the design of programmed explosive charges, adapted to the simulation of a power excursion. This report describes the application of these methods to the investigation of Osiris safety. (author) [French] A la suite des essais effectues aux U.S.A. sur BORAX 1 et SPERT 1 et de l'accident survenu a SL 1, le Commissariat a l'Energie Atomique a lance un programme d'etudes sur la surete de ses reacteurs piscines vis-a-vis des excursions de puissance. Les premieres etudes ont abouti A la mise au point de charges programmees capables de simuler une excursion de puissance. On trouvera dans le present rapport l'application de ces methodes a l'etude de la surete d'OSIRIS. (auteur)

  1. Hyper-systolic matrix multiplication

    NARCIS (Netherlands)

    Lippert, Th.; Petkov, N.; Palazzari, P.; Schilling, K.

    2001-01-01

    A novel parallel algorithm for matrix multiplication is presented. It is based on a 1-D hyper-systolic processor abstraction. The procedure can be implemented on all types of parallel systems. (C) 2001 Elsevier Science B,V. All rights reserved.

  2. A Systolic Array RLS Processor

    OpenAIRE

    Asai, T.; Matsumoto, T.

    2000-01-01

    This paper presents the outline of the systolic array recursive least-squares (RLS) processor prototyped primarily with the aim of broadband mobile communication applications. To execute the RLS algorithm effectively, this processor uses an orthogonal triangularization technique known in matrix algebra as QR decomposition for parallel pipelined processing. The processor board comprises 19 application-specific integrated circuit chips, each with approximately one million gates. Thirty-two bit ...

  3. The Excursion Set Mass Function of Superclusters

    CERN Document Server

    Lim, Seunghwan

    2012-01-01

    The mass function of superclusters is derived fully analytically with the help of the extended excursion set theory and shown to be in excellent agreement with the numerical results from various publicly available N-body simulation database. We introduce a new multi-dimensional barrier model in which the formation of superclusters occurs when the initial shear eigenvalues that perform non-Markovian random walks enter a clustering zone surrounded by one re ecting and two absorbing barriers. The multi-dimensional barrier heights are determined from the first order Lagrangian perturbation theory and found to be independent of redshift and background cosmology. With the help of our analytic model for the supercluster mass function, the relative abundance of the rich superclusters is analytically evaluated at a given epoch and found to be sensitive to the growth rate of the cosmic web. Our result implies that the relative abundance of the rich superclusters at a given epoch may be useful as a cosmological test of ...

  4. EXCURSIONS AND L(E')VY SYSTEM OF BOUNDARY PROCESS

    Institute of Scientific and Technical Information of China (English)

    HE PING; YING JIANGANG

    2003-01-01

    In this paper, the authors investigate the joint distribution of end points of excursion awayfrom a closed set straddling on a fixed time and use this result to compute the Levy systemand the Dirichlet form of the boundary process.

  5. HMSRP Hawaiian Monk Seal Shark Predation Mitigation Fishing Excursions

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Fishing excursion information, including summary tables of: Fishing/culling efforts, including date, islets, latitude/longitude, fishing method, soak times, culled...

  6. Geomagnetic excursions date early hominid migration to China

    Science.gov (United States)

    Bhattacharya, Atreyee

    2012-09-01

    Global-scale geomagnetic reversals, which are periods when the direction of Earth's magnetic field flips, leave imprints in magnetic minerals present in sediments. But so do smaller-scale, even local, changes in Earth's magnetic field direction. Paleomagnetists believe that the smaller-scale events represent “failed reversals” and refer to them as “geomagnetic excursions.” Scientists use geomagnetic excursions in sedimentary basins as markers to tie together events of Earth's history across the globe.

  7. Infinite systolic groups are not torsion

    OpenAIRE

    Prytuła, Tomasz

    2014-01-01

    We study k-systolic complexes introduced by T. Januszkiewicz and J. \\'Swi\\k{a}tkowski, which are simply connected simplicial complexes of simplicial nonpositive curvature. Using techniques of filling diagrams we prove that for k > 6 the 1-skeleton of a k-systolic complex is Gromov hyperbolic. We give an elementary proof of so-called Projection Lemma, which implies contractibility of 6-systolic complexes. We also prove that an infinite group acting geometrically on a 6-systolic complex is not ...

  8. Buoyancy-driven flow excursions in fuel assemblies

    Energy Technology Data Exchange (ETDEWEB)

    Laurinat, J.E.; Paul, P.K.; Menna, J.D.

    1995-12-31

    A power limit criterion was developed for a postulated Loss of Pumping Accident (LOPA) in one of the recently shut down heavy water production reactors at the Savannah River Site. These reactors were cooled by recirculating moderator downward through channels in cylindrical fuel tubes. Powers were limited to prevent a flow excursion from occurring in one or more of these parallel channels. During full-power operation, limits prevented a boiling flow excursion from taking place. At low flow rates, during the addition of emergency cooling water, buoyant forces reverse the flow in one of the coolant channels before boiling occurs. As power increases beyond the point of flow reversal, the maximum wall temperature approaches the fluid saturation temperature, and a thermal excursion occurs. The power limit criterion for low flow rates was the onset of flow reversal. To determine conditions for flow reversal, tests were performed in a mock-up of a fuel assembly that contained two electrically heated concentric tubes surrounded by three flow channels. These tests were modeled using a finite difference thermal-hydraulic code. According to code calculations, flow reversed in the outer flow channel before the maximum wall temperature reached the local fluid saturation temperature. Thermal excursions occurred when the maximum wall temperature approximately equaled the saturation temperature. For a postulated LOPA, the flow reversal criterion for emergency cooling water addition was more limiting than the boiling excursion criterion for full power operation. This criterion limited powers to 37% of historical levels.

  9. Buoyancy-driven flow excursions in fuel assemblies

    Energy Technology Data Exchange (ETDEWEB)

    Laurinat, J.E.; Paul, P.K.; Menna, J.D. [Westinghouse Savannah River Company, Aiken, SC (United States)

    1995-09-01

    A power limit criterion was developed for a postulated Loss of Pumping Accident (LOPA) in one of the recently shut down heavy water production reactors at the Savannah River Site. These reactors were cooled by recirculating heavy water moderator downward through channels in cylindrical fuel tubes. Powers were limited to safeguard against a flow excursion in one of more of these parallel channels. During-full-power operation, limits safeguarded against a boiling flow excursion. At low flow rates, during the addition of emergency cooling water, buoyant forces reverse the flow in one of the coolant channels before boiling occurs. As power increased beyond the point of flow reversal, the maximum wall temperature approaches the fluid saturation temperature, and a thermal excursion occurs. The power limit criterion for low flow rates was the onset of flow reversal. To determine conditions for flow reversal, tests were performed in a mock-up of a fuel assembly that contained two electrically heated concentric tubes surrounded by three flow channels. These tests were modeled using a finite difference thermal-hydraulic code. According to code calculations, flow reversed in the outer flow channel before the maximum wall temperature reached the local fluid saturation temperature. Thermal excursions occurred when the maximum wall temperature approximately equaled the saturation temperature. For a postulated LOPA, the flow reversal criterion for emergency cooling water addition was more limiting than the boiling excursion criterion for full power operation. This criterion limited powers to 37% of the limiting power for previous long-term reactor operations.

  10. Forsmark site investigation. Bedrock geology - overview and excursion guide

    Energy Technology Data Exchange (ETDEWEB)

    Stephens, Michael B. (Geological Survey of Sweden, Uppsala (Sweden))

    2010-09-15

    Bearing in mind the significance of the bedrock data from the ground surface for the geological 3D modelling work, SKB decided to present excursion guides that serve in the demonstration of the bedrock geology at the ground surface in both the Forsmark (this guide) and Laxemar-Simpevarp areas. An excursion guide is also available for the Olkiluoto area in south-western Finland, which has been selected for the construction of a repository for the disposal of highly radioactive, spent nuclear fuel in Finland. The current excursion guide presents the bedrock geology and describes in detail the character of the bedrock at ten representative outcrops or outcrop areas at the ground surface in the site investigation area at Forsmark. All localities are located within or immediately adjacent to the proposed repository volume selected by SKB

  11. Oskarshamn site investigation. Bedrock geology - overview and excursion guide

    Energy Technology Data Exchange (ETDEWEB)

    Wahlgren, Carl-Henric (Geological Survey of Sweden, Uppsala (Sweden))

    2010-09-15

    Bearing in mind the significance of the bedrock data from the ground surface for the geological 3D modelling work, SKB decided to present excursion guides that serve in the demonstration of the bedrock geology at the ground surface in both the Forsmark and Laxemar-Simpevarp (this guide) areas. An excursion guide is also available for the Olkiluoto area in south-western Finland, which has been selected for the construction of a repository for the disposal of highly radioactive, spent nuclear fuel. The current excursion guide presents the bedrock geology and describes in detail the character of the bedrock at eight representative outcrops or outcrop areas at the ground surface in the site investigation area at Laxemar-Simpevarp and at one locality north of this area, i.e. at a total of nine localities

  12. SLAPP: A systolic linear algebra parallel processor

    Energy Technology Data Exchange (ETDEWEB)

    Drake, B.L.; Luk, F.T.; Speiser, J.M.; Symanski, J.J. (Naval Ocean Systems Center and Cornell Univ.)

    1987-07-01

    Systolic array computer architectures provide a means for fast computation of the linear algebra algorithms that form the building blocks of many signal-processing algorithms, facilitating their real-time computation. For applications to signal processing, the systolic array operates on matrices, an inherently parallel view of the data, using numerical linear algebra algorithms that have been suitably parallelized to efficiently utilize the available hardware. This article describes work currently underway at the Naval Ocean Systems Center, San Diego, California, to build a two-dimensional systolic array, SLAPP, demonstrating efficient and modular parallelization of key matric computations for real-time signal- and image-processing problems.

  13. Systolic heart failure: A prothrombotic state

    NARCIS (Netherlands)

    De Peuter, Olav R.; Kok, Wouter E. M; Torp-Pedersen, Christian; Büller, Harry R.; Kamphuisen, Pieter W.

    2009-01-01

    Systolic heart failure is a common syndrome whose incidence is expected to increase. Several treatment modalities, such as -blockers and angiotensin-converting enzyme inhibitors, improve survival. Whether antithrombotic treatment is effective remains to be elucidated, although observations suggest a

  14. The Oxidant Budget of Dissolved Organic Carbon Driven Isotope Excursions

    Science.gov (United States)

    Bristow, T. F.; Kennedy, M. J.

    2008-12-01

    Negative carbon isotope values, falling below the mantle average of about -5 per mil, in carbonate phases of Ediacaran age sedimentary rocks are widely regarded as reflecting negative excursions in the carbon isotopic composition of seawater lasting millions of years. These isotopic signals form the basis of chemostratigraphic correlations between Ediacaran aged sections in different parts of the world, and have been used to track the oxidation of the biosphere. However, these isotopic values are difficult to accommodate within limits prescribed by the current understanding of the carbon cycle, and a hypothetical Precambrian ocean dissolved organic carbon (DOC) pool 100 to 1000 times the size of the modern provides a potential source of depleted carbon not considered in Phanerozoic carbon cycle budgets. We present box model results that show the remineralization of such a DOC pool to drive an isotope excursion of the magnitude observed in the geological record exhausts global budgets of free oxygen and sulfate in 800 k.y. These results are incompatible with the estimated duration of late Ediacaran isotope excursions of more than 10 m.y., as well as geochemical and biological indicators that oceanic sulfate and oxygen levels were maintained or even increased at the same time. Therefore the carbon isotope record is probably not a useful tool for monitoring oxygen levels in the atmosphere and ocean. Covariation between the carbon and oxygen isotope records is often observed during negative excursions and is indicative of local processes or diagenetic overprinting.

  15. Stratigraphic Correlation of an Excursion at 22 kyr in the U.S. Great Basin - the Hilina Pali Excursion?

    Science.gov (United States)

    Liddicoat, J. C.; Coe, R. S.

    2013-12-01

    An unusually large secular variation of the geomagnetic field recorded in outcrops of pluvial Lake Russell sediment about 22 kyr old in the Mono Basin, CA, can be used for precise correlation to other lacustrine sections in the western U.S., and perhaps beyond. We present new AF and thermal demagnetization results for paired samples at 2-cm intervals between ash layers 7 and 8 of Lajoie (1968) in the bank of Wilson Creek that document an excursion having an inclination as low as 16 degrees and as high as 73 degrees, while the declination swings from 15 degrees west during the low inclination to 30 east when the inclination is high, and back to average northerly declination and expected inclination. The corresponding VGPs form a narrow clockwise-trending loop centered at about 50 N, 30 E. The Mono Lake Excursion (MLE; Liddicoat and Coe, 1979) occurs 1.7 m lower in the same section. The best estimates for the ages of the two excursions are about 22 and 32 kyr, based on 14-C dates (Cassata et al., 2010). About 150 km to the north, sediments of about the same age exposed along the Truckee River that were deposited in pluvial Lake Lahontan record a similar geomagnetic signature. Moreover, both the MLE and this excursion are exhibited at the appropriate levels in a sediment core taken from Pyramid Lake, the remnant of Lake Lahontan (Benson et al., 2008). Thus, this excursion is a valuable marker for high-resolution correlation of Quaternary sediments in the western U.S., especially when paired with the MLE. It is tempting to try to identify this geomagnetic feature with others of about the same age further away. On the island of Hawaii, Coe et al. (1978) discovered a lava flow on the Hilina Pali with a calibrated 14-C age of 21 +/-1 kyr that has an inclination about 30 degrees shallower and a paleointensity 60 percent lower than today. Later Teanby et al. (2002) documented an excursion with inclinations as low as -35 degrees, recorded by around 40 successive flows with

  16. Does the Shuram δ13C excursion record Ediacaran oxygenation?

    Science.gov (United States)

    Husson, J. M.; Maloof, A. C.; Schoene, B.; Higgins, J. A.

    2013-12-01

    The most negative carbon isotope excursion in Earth history is found in carbonate rocks of the Ediacaran Period (635-542 Ma). Known colloquially as the the 'Shuram' excursion, workers have long noted its tantalizing, broad concordance with the rise of abundant macro-scale fossils in the rock record, variously interpreted as animals, giant protists, macro-algae and lichen, and known as the 'Ediacaran Biota.' Thus, the Shuram excursion has been interpreted by many in the context of a dramatically changing redox state of the Ediacaran oceans - e.g., a result of methane cycling in a low O2 atmosphere, the final destruction of a large pool of recalcitrant dissolved organic carbon (DOC), and the step-wise oxidation of the Ediacaran oceans. More recently, diagenetic interpretations of the Shuram excursion - e.g. sedimentary in-growth of very δ13C depleted authigenic carbonates, meteoric alteration of Ediacaran carbonates, late-stage burial diagenesis - have challenged the various Ediacaran redox models. A rigorous geologic context is required to discriminate between these explanatory models, and determine whether the Shuram excursion can be used to evaluate terminal Neoproterozoic oxygenation. Here, we present chemo-stratigraphic data (δ13C, δ18O, δ44/42Ca and redox sensitive trace element abundances) from 12 measured sections of the Ediacaran-aged Wonoka Formation (Fm.) of South Australia that require a syn-depositional age for the extraordinary range of δ13C values (-12 to +4‰) observed in the formation. In some locations, the Wonoka Fm. is ~700 meters (m) of mixed shelf limestones and siliclastics that record the full 16 ‰ δ13C excursion in a remarkably consistent fashion across 100s of square kilometers of basin area. Fabric-altering diagenesis, where present, occurs at the sub-meter vertical scale, only results in sub-permil offsets in δ13C and cannot be used to explain the full δ13C excursion. In other places, the Wonoka Fm. is host to deep (1 km

  17. Ultrasonographic assessment of flexor tendon mobilization: Effect of different protocols on tendon excursion

    NARCIS (Netherlands)

    J.-W.H. Korstanje (Jan-Wiebe); J. Soeters (Johannes); A.R. Schreuders (Ton); P.C. Amadio (Peter ); S.E.R. Hovius (Steven); H.J. Stam (Henk); R.W. Selles (Ruud)

    2012-01-01

    textabstractBackground: Different mobilization protocols have been proposed for rehabilitation after hand flexor tendon repair to provide tendon excursion sufficient to prevent adhesions. Several cadaver studies have shown that the position of the neighboring fingers influences tendon excursions of

  18. Ultrasonographic assessment of flexor tendon mobilization: Effect of different protocols on tendon excursion

    NARCIS (Netherlands)

    J.-W.H. Korstanje (Jan-Wiebe); J. Soeters (Johannes); A.R. Schreuders (Ton); P.C. Amadio (Peter ); S.E.R. Hovius (Steven); H.J. Stam (Henk); R.W. Selles (Ruud)

    2012-01-01

    textabstractBackground: Different mobilization protocols have been proposed for rehabilitation after hand flexor tendon repair to provide tendon excursion sufficient to prevent adhesions. Several cadaver studies have shown that the position of the neighboring fingers influences tendon excursions of

  19. Evaluation of Systolic Synchronicity in Patients with Dilated Cardiomyopathy by V-plane Imaging with CAMM%V-plane显像结合CAMM评价扩张型心肌病患者左室收缩同步性的初步研究

    Institute of Scientific and Technical Information of China (English)

    宋宏宁; 郭瑞强; 陈长远; 周青; 陈金玲

    2014-01-01

    目的 应用实时V形双平面(V-plane)结合曲线解剖M型(CAMM)技术评价扩张型心肌病(DCM)患者左心室收缩不同步现现象,并与临床常用的TDI技术进行对比.方法 对25例DCM患者及22例健康对照者进行超声检查,获取二维图像、V-plane双平面及CAMM图像,TDI检查获取频谱图像,测量左室12节段TDI脉冲频谱达峰时间,并计算其标准差(TDI_ SD),测量V-plane显像中12节段收缩位移达峰时间,并计算其标准差(V-plane_ SD).结果 与对照组相比DCM组的TDI_ SD和V-plane_SD增大,差异有统计学意义(P<0.01);DCM组TDI达峰时间延迟,V-plane达峰时间缩短,差异有统计学意义(P<0.01);ROC曲线显示V-plane_SD和TDI_ SD的曲线下面积分别为0.906和0.912.所有纳入病例中V-plane与TDI所测量的收缩达峰时间标准差具有显著相关性(r=0.914,P<0.001),平均收缩达峰时间不具有相关性(r=0.154,P=0.302),DCM组中V-plane与TDI所测量平均收缩达峰时间不具有相关性(r=0.129,P=0.540),对照组中其平均收缩达峰时间具有显著相关性(r=0.500,P=0.018).结论 V-plane结合CAMM技术可以准确地观察DCM患者左心室的收缩不同步现象,并且能克服现有技术不能在同一心动周期显示12节段的局限性.

  20. TFIT Modeling of Wave Propagation for Flow Excursion

    OpenAIRE

    Grubbs, Brachston; Chetty, Krishna; Bertodano, Martin

    2016-01-01

    In the nuclear power industry, the Two-Fluid Model (TFM) is mainly used in the simulation of Loss of Coolant Accident (LOCA). The Two-Fluid Model is a wave mechanics formulation that may also be used to analytically perform stability analysis, which requires numerous assumptions and simplifications. This project aimed to advance the TFIT-TFM simulations in the modeling of the flow excursion instability. By using the TFIT computational code, simulation results can be obtained without the need ...

  1. Non-Gaussianity and Excursion Set Theory: Halo Bias

    Energy Technology Data Exchange (ETDEWEB)

    Adshead, Peter [Enrico Fermi Institute, Univ. of Chicago, IL (United States); Baxter, Eric J. [Univ. of Chicago, Chicago, IL (United States); Dodelson, Scott [Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States); Lidz, Adam [Univ. of Pennsylvania, Philadelphia, PA (United States)

    2012-09-01

    We study the impact of primordial non-Gaussianity generated during inflation on the bias of halos using excursion set theory. We recapture the familiar result that the bias scales as $k^{-2}$ on large scales for local type non-Gaussianity but explicitly identify the approximations that go into this conclusion and the corrections to it. We solve the more complicated problem of non-spherical halos, for which the collapse threshold is scale dependent.

  2. Speckle tracking as a method to measure hemidiaphragm excursion.

    Science.gov (United States)

    Goutman, Stephen A; Hamilton, James D; Swihart, Blake; Foerster, Bradley; Feldman, Eva L; Rubin, Jonathan M

    2017-01-01

    Diaphragm excursion measured via ultrasound may be an important imaging outcome measure of respiratory function. We developed a new method for measuring diaphragm movement and compared it to the more traditional M-mode method. Ultrasound images of the right and left hemidiaphragms were collected to compare speckle tracking and M-mode measurements of diaphragm excursion. Speckle tracking was performed using EchoInsight (Epsilon Imaging, Ann Arbor, Michigan). Six healthy subjects without a history of pulmonary diseases were included in this proof-of-concept study. Speckle tracking of the diaphragm is technically possible. Unlike M-mode, speckle tracking carries the advantage of reliable visualization and measurement of the left hemidiaphragm. Speckle tracking accounted for diaphragm movement simultaneously in the cephalocaudad and mediolateral directions, unlike M-mode, which is 1-dimensional. Diaphragm speckle tracking may represent a novel, more robust method for measuring diaphragm excursion, especially for the left hemidiaphragm. Muscle Nerve 55: 125-127, 2017. © 2016 Wiley Periodicals, Inc.

  3. Excursion Sets and Non-Gaussian Void Statistics

    CERN Document Server

    D'Amico, Guido; Noreña, Jorge; Paranjape, Aseem

    2010-01-01

    Primordial non-Gaussianity (NG) affects the large scale structure (LSS) of the universe by leaving an imprint on the distribution of matter at late times. Much attention has been focused on using the distribution of collapsed objects (i.e. dark matter halos and the galaxies and galaxy clusters that reside in them) to probe primordial NG. An equally interesting and complementary probe however is the abundance of extended underdense regions or voids in the LSS. The calculation of the abundance of voids using the excursion set formalism in the presence of primordial NG is subject to the same technical issues as the one for halos, which were discussed e.g. in arXiv:1005.1203. However, unlike the excursion set problem for halos which involved random walks in the presence of one barrier $\\delta_c$, the void excursion set problem involves two barriers $\\delta_v$ and $\\delta_c$. This leads to a new complication introduced by what is called the "void-in-cloud" effect discussed in the literature, which is unique to the...

  4. Age of the Mono Lake excursion and associated tephra

    Science.gov (United States)

    Benson, L.; Liddicoat, J.; Smoot, J.; Sarna-Wojcicki, A.; Negrini, R.; Lund, S.

    2003-01-01

    The Mono Lake excursion (MLE) is an important time marker that has been found in lake and marine sediments across much of the Northern Hemisphere. Dating of this event at its type locality, the Mono Basin of California, has yielded controversial results with the most recent effort concluding that the MLE may actually be the Laschamp excursion (Earth Planet. Sci. Lett. 197 (2002) 151). We show that a volcanic tephra (Ash #15) that occurs near the midpoint of the MLE has a date (not corrected for reservoir effect) of 28,620 ?? 300 14C yr BP (??? 32,400 GISP2 yr BP) in the Pyramid Lake Basin of Nevada. Given the location of Ash #15 and the duration of the MLE in the Mono Basin, the event occurred between 31,500 and 33,300 GISP2 yr BP, an age range consistent with the position and age of the uppermost of two paleointensity minima in the NAPIS-75 stack that has been associated with the MLE (Philos. Trans. R. Soc. London Ser. A 358 (2000) 1009). The lower paleointensity minimum in the NAPIS-75 stack is considered to be the Laschamp excursion (Philos. Trans. R. Soc. London Ser. A 358 (2000) 1009).

  5. Wafer-Scale Integration of Systolic Arrays,

    Science.gov (United States)

    1985-10-01

    wafer-scale system, however, all the nearest neighbors of a processor may be dead, and thus the prime advantage of adopting a systolic array...work, however. To the best of our knowledge, the only result of a similar nature is due to Erdos and Renyi 15] who showed that most graphs with N

  6. Is hydrotherapy an appropriate form of exercise for elderly patients with biventricular systolic heart failure?

    Science.gov (United States)

    Sveälv, Bente Grüner; Täng, Margareta Scharin; Cider, Åsa

    2012-01-01

    Hydrotherapy (exercise in warm water) is considered to be a safe and beneficial method to use in the rehabilitation of stable heart failure patients, but there is little information on the effect of the increased venous return and enhanced preload in elderly patients with biventricular heart failure. We present a case of an elderly man who was recruited to participate in a hydrotherapy study. We compared echocardiographic data during warm water immersion with land measurements, and observed increases in stroke volume from 32 mL (land) to 42 mL (water), left ventricular ejection fraction from 22% to 24%, left ventricular systolic velocity from 4.8 cm/s to 5.0 cm/s and left atrioventricular plane displacement from 2.1 mm to 2.2 mm. By contrast, right ventricular systolic velocity decreased from 11.2 cm/s to 8.4 cm/s and right atrioventricular plane displacement from 8.1 mm to 4.7 mm. The tricuspid pressure gradient rose from 18 mmHg on land to 50 mmHg during warm water immersion. Thus, although left ventricular systolic function was relatively unaffected during warm water immersion, we observed a decrease in right ventricular function with an augmented right ventricular pressure. We recommend further investigations to observe the cardiac effect of warm water immersion on patients with biventricular systolic heart failure and at risk of elevated right ventricular pressure. PMID:23341846

  7. Is hydrotherapy an appropriate form of exercise for elderly patients with biventricular systolic heart failure?

    Institute of Scientific and Technical Information of China (English)

    Bente Grüer Sve(a)v1,; Margareta Scharin T(a)ng,; (A)sa Cider

    2012-01-01

    Hydrotherapy (exercise in warm water) is considered to be a safe and beneficial method to use in the rehabilitation of stable heart failure patients, but there is little information on the effect of the increased venous return and enhanced preload in elderly patients with biventricular heart failure. We present a case of an elderly man who was recruited to participate in a hydrotherapy study. We compared echocardiographic data during warm water immersion with land measurements, and observed increases in stroke volume from 32 mL (land) to 42 mL (water), left ventricular ejection fraction from 22% to 24%, left ventricular systolic velocity from 4.8 cm/s to 5.0 cm/s and left atrioventricular plane displacement from 2.1 mm to 2.2 mm. By contrast, right ventricular systolic velocity decreased from 11.2 cm/s to 8.4 cm/s and right atrioventricular plane displacement from 8.1 mm to 4.7 mm. The tricuspid pressure gradient rose from 18 mmHg on land to 50 mmHg during warm water immersion. Thus, although left ventricular systolic function was relatively unaffected during warm water immersion, we observed a decrease in right ventricular function with an augmented right ventricular pressure. We recommend further investigations to observe the cardiac effect of warm water immersion on patients with biventricular systolic heart failure and at risk of elevated right ventricular pressure.

  8. Aortic annulus dimension assessment by computed tomography for transcatheter aortic valve implantation: differences between systole and diastole.

    Science.gov (United States)

    Bertaso, Angela G; Wong, Dennis T L; Liew, Gary Y H; Cunnington, Michael S; Richardson, James D; Thomson, Viji S; Lorraine, Brett; Kourlis, George; Leech, Diana; Worthley, Matthew I; Worthley, Stephen G

    2012-12-01

    Accurate assessment of aortic annular dimensions is essential for successful transcatheter aortic valve implantation (TAVI). Annular dimensions are conventionally measured in mid-systole by multidetector computed tomography (MDCT), echocardiography and angiography. Significant differences in systolic and diastolic aortic annular dimensions have been demonstrated in cohorts without aortic stenosis (AS), but it is unknown whether similar dynamic variation in annular dimensions exists in patients with severe calcific AS in whom aortic compliance is likely to be substantially reduced. We investigated the variation in aortic annular dimensions between systole and diastole in patients with severe calcific AS. Patients with severe calcific AS referred for TAVI were evaluated by 128-slice MDCT. Aortic annular diameter was measured during diastole and systole in the modified coronal, modified sagittal, and basal ring planes (maximal, minimal and mean diameters). Differences between systole and diastole were analysed by paired t test. Fifty-nine patients were included in the analysis. Three of the five aortic dimensions measured increased significantly during systole. The largest change was a 0.75 mm (3.4%) mean increase in the minimal diameter of the basal ring during systole (p = 0.004). This corresponds closely to the modified sagittal view, which also increased by mean 0.42 mm (1.9%) during systole (p = 0.008). There was no significant change in the maximal diameter of the basal ring or the modified coronal view during systole (p > 0.05). There is a small magnitude but statistically significant difference in aortic annulus dimensions of patients with severe AS referred for TAVI when measured in diastole and systole. This small difference is unlikely to alter clinical decisions regarding prosthesis size or suitability for TAVI.

  9. Hyperellipticity and Systoles of Klein Surfaces

    CERN Document Server

    Katz, Mikhail G

    2012-01-01

    Given a hyperelliptic Klein surface, we construct companion Klein bottles, extending our technique of companion tori already exploited by the authors in the genus 2 case. Bavard's short loops on such companion surfaces are studied in relation to the original surface so to improve a systolic inequality of Gromov's. A basic idea is to use length bounds for loops on a companion Klein bottle, and then analyze how curves transplant to the original nonorientable surface. We exploit the real structure on the orientable double cover by applying the coarea inequality to the distance function from the real locus. Of particular interest is the case of Dyck's surface. We also exploit an optimal systolic bound for the M\\"obius band, due to Blatter.

  10. Systolic heart failure: a prothrombotic state

    DEFF Research Database (Denmark)

    de Peuter, Olav R; Kok, Wouter E M; Torp-Pedersen, Christian

    2009-01-01

    Systolic heart failure is a common syndrome whose incidence is expected to increase. Several treatment modalities, such as beta-blockers and angiotensin-converting enzyme inhibitors, improve survival. Whether antithrombotic treatment is effective remains to be elucidated, although observations...... suggest a prothrombotic state in heart failure. This article focuses on this prothrombotic state and discusses the risk of thromboembolic events, pathophysiological mechanisms, and the potential role of anticoagulant treatment....

  11. Systolic Time Intervals and New Measurement Methods.

    Science.gov (United States)

    Tavakolian, Kouhyar

    2016-06-01

    Systolic time intervals have been used to detect and quantify the directional changes of left ventricular function. New methods of recording these cardiac timings, which are less cumbersome, have been recently developed and this has created a renewed interest and novel applications for these cardiac timings. This manuscript reviews these new methods and addresses the potential for the application of these cardiac timings for the diagnosis and prognosis of different cardiac diseases.

  12. Right inverses of Levy processes: the excursion measure in the general case

    CERN Document Server

    Savov, Mladen

    2010-01-01

    This article is about right inverses of Levy processes as first introduced by Evans in the symmetric case and later studied systematically by the present authors and their co-authors. Here we add to the existing fluctuation theory an explicit description of the excursion measure away from the (minimal) right inverse. This description unifies known formulas in the case of a positive Gaussian coefficient and in the bounded variation case. While these known formulas relate to excursions away from a point starting negative continuously, and excursions started by a jump, the present description is in terms of excursions away from the supremum continued up to a return time. In the unbounded variation case with zero Gaussian coefficient previously excluded, excursions start negative continuously, but the excursion measures away from the right inverse and away from a point are mutually singular. We also provide a new construction and a new formula for the Laplace exponent of the minimal right inverse.

  13. Spinodal Instabilities and Super-Planckian Excursions in Natural Inflation

    CERN Document Server

    Albrecht, Andreas; Richard, Benoit J

    2014-01-01

    Models such as Natural Inflation that use Pseudo-Nambu-Goldstone bosons (PNGB's) as the inflaton are attractive for many reasons. However, they typically require trans-Planckian field excursions $\\Delta \\Phi>M_{\\rm Pl}$, due to the need for an axion decay constant $f>M_{\\rm Pl}$ to have both a sufficient number of e-folds {\\em and} values of $n_s,\\ r$ consistent with data. Such excursions would in general require the addition of all other higher dimension operators consistent with symmetries, thus disrupting the required flatness of the potential and rendering the theory non-predictive. We show that in the case of Natural Inflation, the existence of spinodal instabilities (modes with tachyonic masses) can modify the inflaton equations of motion to the point that versions of the model with $f

  14. Magnetosheath excursion and the relevant transport process at the magnetopause

    Directory of Open Access Journals (Sweden)

    C. L. Cai

    2009-08-01

    Full Text Available A large-amplitude excursion of the magnetosheath (MS in quiet solar wind conditions on 17 March 2004 was recorded simultaneously by the Cluster and TC-1 spacecraft. During this period, the IMF Bz was entirely northward. The coherence between the bow shock motion and magnetopause (MP motion is revealed and the excursion velocities of the bow shock motion are analyzed. In addition, the relevant plasma transport phenomenon in the form of flux fluctuations below the ion gyrofrequency at the MP is exposed and is interpreted as manifestation of the drift instability. Correlated observations on charge accumulation and electrostatic potential perturbation are recorded by electron measurements in high energy regime, and also the eventual cross-field vortex motion in the nonlinear stage and the consequential mass exchange are exhibited. The present investigation gives some new insight into the MS plasma transport mechanism across the subsolar MP region in quiet solar wind conditions during a period of northward IMF.

  15. Levator excursion as a predictor of both eyelid lag and lagophthalmos in thyroid eye disease.

    Science.gov (United States)

    Lelli, Gary J; Duong, Jimmy K; Kazim, Michael

    2010-01-01

    To evaluate the relationship between levator excursion and both eyelid lag and lagophthalmos in thyroid eye disease. We retrospectively reviewed 104 eyelids of 52 thyroid eye disease patients over a 9-month interval by measuring levator function (mm), eyelid lag (0-4+) and lagophthalmos (mm). Lower levator excursion is associated with higher eyelid lag scores (p lagophthalmos (p lagophthalmos increases on average by 0.23 mm. Diminished levator excursion is associated with increasing levels of eyelid lag and lagophthalmos. Levator excursion is an important clinical measurement in thyroid eye disease patients and may replace eyelid lag grading and lagophthalmos as a more accurate indicator of eyelid retraction in thyroid eye disease.

  16. Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms.

    NARCIS (Netherlands)

    Zannad, Faiez; McMurray, John J. V.; Krum, Henry; van Veldhuisen, Dirk J.; Swedberg, Karl; Shi, Harry; Vincent, John; Pocock, Stuart J.; Pitt, Bertram

    2011-01-01

    Background: Mineralocorticoid antagonists improve survival among patients with chronic, severe systolic heart failure and heart failure after myocardial infarction. We evaluated the effects of eplerenone in patients with chronic systolic heart failure and mild symptoms. Methods: In this randomized,

  17. Mitral annular systolic velocity as a marker of preclinical systolic dysfunction among patients with arterial hypertension

    Directory of Open Access Journals (Sweden)

    Daskalov Ivaylo Rilkov

    2012-11-01

    Full Text Available Abstract Background The aim of this study was to investigate early changes in left ventricular longitudinal systolic function in patients with hypertension (HTN with and without concomitant diastolic dysfunction (DD and the clinical implications of these findings. Method We enrolled 299 patients with HTN and 297 age-matched patients with HTN and DD and compared both groups with an age-matched control group consisting of 100 healthy subjects. The long axis systolic function was investigated by determining the average peak systolic velocity of the septal and lateral mitral sites (Smavg using spectral pulsed wave tissue Doppler imaging (TDI. Results We found a strong negative trend toward the reduction of velocity, which is dependent on the grade of HTN, on the magnitude of DD, and also on the gender and age of the subjects (r=−0.891/-0.580; p Conclusion The strength of the study is the analysis of incremental changes in longitudinal contraction in patients with different stage of HTN but not so many the classification of the degree of systolic dysfunction. The importance of our results lies in the fact that these initial changes in systolic contraction could be used as an early sign that should prompt optimization of the treatment of HTN.

  18. Treatment of anemia with darbepoetin alfa in systolic heart failure

    DEFF Research Database (Denmark)

    Swedberg, Karl; Young, James B; Anand, Inder S

    2013-01-01

    Patients with systolic heart failure and anemia have worse symptoms, functional capacity, and outcomes than those without anemia. We evaluated the effects of darbepoetin alfa on clinical outcomes in patients with systolic heart failure and anemia.......Patients with systolic heart failure and anemia have worse symptoms, functional capacity, and outcomes than those without anemia. We evaluated the effects of darbepoetin alfa on clinical outcomes in patients with systolic heart failure and anemia....

  19. Matrix Formalism of Excursion Set Theory: A new approach to statistics of dark matter halo counting

    CERN Document Server

    Nikakhtar, Farnik

    2016-01-01

    Excursion Set Theory (EST) is an analytical framework to study the large scale structure of the Universe. EST introduces a procedure to calculate the number density of structures by relating the non-linear structures to cosmological linear perturbation theory. In this work, we introduce a novel approach to re-formulate the EST in Matrix Formalism. It is proposed that the matrix representation of EST will facilitate the the calculations in framework of the large scale structure observables. The method is to discretize the two dimensional plane of variance and density contrast of EST, where the trajectories for each point in the Universe lived there. The probability of having a density contrast in a chosen variance is represented by a probability ket. Naturally the concept of the transition matrix pops up to define the trajectories in EST. We show that in the case of Markovianity of the process, the probability ket, at a specific variance can be constructed by knowing the transition matrix and the initial proba...

  20. Low-complexity systolic architecture for inversion

    Institute of Scientific and Technical Information of China (English)

    Yuan Danshou; Rong Mengtian

    2006-01-01

    A modified extended binary Euclid's algorithm which is more regularly iterative for computing an inversion in GF(2m) is presented. Based on above modified algorithm, a serial-in serial-out architecture is proposed. It has area complexity of O(m), latency of 5m-2, and throughput of 1/m. Compared with other serial systolic architectures, the proposed one has the smallest area complexity, shorter latency. It is highly regular, modular, and thus well suited for high-speed VLSI design.

  1. Statistics of Dark Matter Halos from the Excursion Set Approach

    CERN Document Server

    Lapi, A; Danese, L

    2013-01-01

    We exploit the excursion set approach in integral formulation to derive novel, accurate analytic approximations of the unconditional and conditional first crossing distributions, for random walks with uncorrelated steps and general shapes of the moving barrier; we find the corresponding approximations of the unconditional and conditional halo mass functions for Cold Dark Matter power spectra to represent very well the outcomes of state-of-the-art cosmological N-body simulations. In addition, we apply these results to derive and confront with simulations other quantities of interest in halo statistics, including the rates of halo formation and creation, the average halo growth history, and the halo bias. Finally, we discuss how our approach and main results change when considering random walks with correlated instead of uncorrelated steps, and Warm instead of Cold Dark Matter power spectra.

  2. Large field excursions from a few site relaxion model

    Science.gov (United States)

    Fonseca, N.; de Lima, L.; Machado, C. S.; Matheus, R. D.

    2016-07-01

    Relaxion models are an interesting new avenue to explain the radiative stability of the Standard Model scalar sector. They require very large field excursions, which are difficult to generate in a consistent UV completion and to reconcile with the compact field space of the relaxion. We propose an N -site model which naturally generates the large decay constant needed to address these issues. Our model offers distinct advantages with respect to previous proposals: the construction involves non-Abelian fields, allowing for controlled high-energy behavior and more model building possibilities, both in particle physics and inflationary models, and also admits a continuum limit when the number of sites is large, which may be interpreted as a warped extra dimension.

  3. Analysis of HCDA Power Excursions in KALIMER-150

    Energy Technology Data Exchange (ETDEWEB)

    Suk, S. D.; Lee, Y. B. [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    2006-07-01

    A number of calculations have been performed to analyze the hypothetical super-prompt-critical power excursion of KALIMER-150 for various reactivity insertion rates, ranging from 10$/s up to 100$/s, using the VENUS-II code modified for the analysis of a metal fueled core. Parametric studies were also carried out in this study to investigate the sensitivity of the calculations to the initial power level and temperature distributions, which are among the major initial conditions of uncertainties expected to influence the analysis results Some of the major changes made in this study to apply the VENUS-II code to the CDA analysis of the KALIMER-150 include the reactivity feedback models and the equations of state of pressure-energy density relationship for the metallic fuel. The equations of state were derived for the saturated-vapor as well as the single phase liquid of the metallic uranium fuel.

  4. Vertical orbit excursion fixed field alternating gradient accelerators

    Science.gov (United States)

    Brooks, Stephen

    2013-08-01

    Fixed field alternating gradient (FFAG) accelerators with vertical orbit excursion (VFFAGs) provide a promising alternative design for rings with fixed-field superconducting magnets. They have a vertical magnetic field component that increases with height in the vertical aperture, yielding a skew quadrupole focusing structure. Scaling-type VFFAGs are found with fixed tunes and no intrinsic limitation on momentum range. This paper presents the first multiparticle tracking of such machines. Proton driver rings to accelerate the 800 MeV beam from the ISIS synchrotron are presented, in terms of both magnet field geometry and longitudinal behavior during acceleration with space charge. The 12 GeV ring produces an output power of at least 2.18 MW. Possible applications of VFFAGs to waste transmutation, hadron therapy, and energy-recovery electron accelerators are also discussed.

  5. Proofs of the Cantor-Bernstein theorem a mathematical excursion

    CERN Document Server

    Hinkis, Arie

    2013-01-01

    This book offers an excursion through the developmental area of research mathematics. It presents some 40 papers, published between the 1870s and the 1970s, on proofs of the Cantor-Bernstein theorem and the related Bernstein division theorem. While the emphasis is placed on providing accurate proofs, similar to the originals, the discussion is broadened to include aspects that pertain to the methodology of the development of mathematics and to the philosophy of mathematics. Works of prominent mathematicians and logicians are reviewed, including Cantor, Dedekind, Schröder, Bernstein, Borel, Zermelo, Poincaré, Russell, Peano, the Königs, Hausdorff, Sierpinski, Tarski, Banach, Brouwer and several others mainly of the Polish and the Dutch schools. In its attempt to present a diachronic narrative of one mathematical topic, the book resembles Lakatos’ celebrated book Proofs and Refutations. Indeed, some of the observations made by Lakatos are corroborated herein. The analogy between the two books is clearly an...

  6. Phanerozoic and Neoproterozoic Negative Carbon Isotope Excursions, Diagenesis and Terrestrialization

    Science.gov (United States)

    Paul, K.; Kennedy, M. J.

    2008-12-01

    Comprehensive data sets of Phanerozoic and late Precambrian carbon isotope data derived from carbonate rocks show a similar positive relation when cross-plotted with oxygen isotope values. The range and slope between the time periods is identical and the processes responsible for the relation have been well documented in Quaternary sediments. These processes include the stabilization of isotope values to ambient meteoric water values during shallow burial and flushing of carbonate sediments. Both data sets show strongly depleted carbon (-9 per mil PDB) and oxygen isotope values that retain seemingly systematic stratigraphic patterns with the Quaternary and Phanerozoic examples that demonstrably record meteroric water values. Similar values and patterns in the Precambrian are interpreted as primary marine in origin with significant implications for an ocean carbon mass balance not possible in the Phanerozoic carbon cycle. A similar compilation of carbonates older than one billion years do not show a relation between carbon and oxygen isotopes, lacking the negative carbon values evident in the younger record. We hypothesize that this difference records the onset of significant organic carbon on the land surface and the alteration of meteoric waters toward Phanerozoic values. We demonstrate the meteoric affinities of Neoproterozoic carbonates containing prominent negative isotope excursions recorded in the Shuram and Wonoka Formations of Oman and South Australia commonly attributed to whole ocean isotope variation. The conspicuous absence of negative carbon isotope values with normal marine oxygenisotope values in the Phanerozoic and Neoproterozic identifies a consistent relation between these time intervals and suggests that, as well accepted in the Phanerozoic, negative carbon isotope excursions less than -3 per mil are not a record of marine processes, but rather the later terrestrial biotic influence on meteoric water values.

  7. Translator’s inferential excursions, with imagination in the background

    Directory of Open Access Journals (Sweden)

    Bożena Tokarz

    2014-01-01

    Full Text Available In a literary work, signals that trigger reader’s inferential excursions allow the reader’s imagination to identify with and control the represented world. They constitute an important element of sense-generating mechanism. Thanks to imagination, the translator imitates the inferential mechanism of the original on various level’s of the text’s structure, activating the imagination of the reader. The translator’s imagination is bi- or multivalent in having the linguistic-semiotic, literary, and cultural quality. Although it manifests itself in language, it goes beyond the boundaries of language. Imagination is a form of consciousness which has no object of its own, and a medium connecting a specific non-imaginary knowledge with representations. It constitutes a mind faculty shaped on the basis of sensory and mental perception. It is derived from individual principles of perception and cognition data processing. It usually requires a stymulus to activate the capabilities of the imagining subject. As a mind faculty, imagination is based on the mental capability common to all people, which is the ability to create chains of associations.Translator’s respect for inferential excursions in the original text is necessary for retaining the original meaning, regardless of whether they occur on the phonetic-phonological level (as in Ionesco’s The Chairs, or on the level of image-semantic and syntactic relations (as in translation of Apollinaire’s Zone, or on the level of syntax (as in translation of Mrożek’s short stories into Slovenian, or on the level of cultural communication (as in Slovenian translation of Gombrowicz’s Trans-Atlantic.

  8. A Central Limit Theorem for the Volumes of High Excursions of Stationary Associated Random Fields

    Directory of Open Access Journals (Sweden)

    Vadim Demichev

    2015-05-01

    Full Text Available We prove that under certain conditions the excursion sets volumes of stationary positively associated random fields converge after rescaling to the normal distribution as the excursion level and the size of the observation window grow. In addition, we provide a number of examples.

  9. Systolic hypertension: an increasing clinical challenge in Asia

    Science.gov (United States)

    Park, Jeong Bae; Kario, Kazuomi; Wang, Ji-Guang

    2015-01-01

    Systolic hypertension, the predominant form of hypertension in patients aged over 50–60 years, is a growing health issue as the Asian population ages. Elevated systolic blood pressure is mainly caused by arterial stiffening, resulting from age-related vascular changes. Elevated systolic pressure increases the risk of cardiovascular disease, mortality and renal function decline, and this risk may increase at lower systolic pressure levels in Asian than Western subjects. Hence, effective systolic pressure lowering is particularly important in Asians yet blood pressure control remains inadequate despite the availability of numerous antihypertensive medications. Reasons for poor blood pressure control include low awareness of hypertension among health-care professionals and patients, under-treatment, and tolerability problems with antihypertensive drugs. Current antihypertensive treatments also lack effects on the underlying vascular pathology of systolic hypertension, so novel drugs that address the pathophysiology of arterial stiffening are needed for optimal management of systolic hypertension and its cardiovascular complications. PMID:25503845

  10. Optical systolic solutions of linear algebraic equations

    Science.gov (United States)

    Neuman, C. P.; Casasent, D.

    1984-01-01

    The philosophy and data encoding possible in systolic array optical processor (SAOP) were reviewed. The multitude of linear algebraic operations achievable on this architecture is examined. These operations include such linear algebraic algorithms as: matrix-decomposition, direct and indirect solutions, implicit and explicit methods for partial differential equations, eigenvalue and eigenvector calculations, and singular value decomposition. This architecture can be utilized to realize general techniques for solving matrix linear and nonlinear algebraic equations, least mean square error solutions, FIR filters, and nested-loop algorithms for control engineering applications. The data flow and pipelining of operations, design of parallel algorithms and flexible architectures, application of these architectures to computationally intensive physical problems, error source modeling of optical processors, and matching of the computational needs of practical engineering problems to the capabilities of optical processors are emphasized.

  11. Deciphering Carbon Isotope Excursions in Separated Biogenic and Diagenetic Carbonates

    Science.gov (United States)

    Hermoso, M.; Minoletti, F.; Hesselbo, S.; Jenkyns, H.; Rickaby, R.; Diester-Haass, L.; Delsate, D.

    2008-12-01

    The long-term evolution of the carbon-isotope ratio in the sedimentary archive is classically linked with changes in primary productivity and organic matter burial. There have been sudden and pronounced shifts, so-called Carbon Isotope Excursions (CIEs) in the long-term trends as evidenced by synchronous shifts from various basins. These geochemical perturbations may have various explanations such as changes of the efficiency of the carbon sink; sudden infusion of isotopically-light carbon into the Ocean-Atmosphere system; or advection of 12C-rich source from bottom water in a stratified water column. Beside the record of primary changes in seawater chemistry, a possible diagenetic overprint may also mime such CIEs in the sedimentary record. The aim of this contribution is to illustrate through three critical intervals (the Early Toarcian, the K-P boundary and the Mid-Miocene Montery Event) how the various micron-sized sedimentary particles specifically record these CIEs, which are respectively associated with major paleoceanographical events. New techniques for getting monotaxic calcareous nannofossil assemblages from the sediment (Minoletti et al., accepted) enable the isotopic measurement at various depths within the surface water and from bottom water by analyzing early diagenetic precipitations (rhombs and micarbs). The integration of these high-resolution isotopic signals in terms of amplitudes affords to recognize diagenetic artifacts in some sections displaying coeval decrease in the carbonate content. For both Early Toarcian and K-P events, corroborative records of CIE records in both primary calcite and bottom water carbonate indicate a global C-isotope perturbation of the water column. For the Monterey event, the evolution of calcareous nannoplankton and the foraminifera isotopic records are in overall agreement, but in detail, the coccolith-discoaster and foraminifer ratio in the sediment, related to environmental changes, is likely to produce isotopic

  12. Fixed Sagittal Plane Imbalance

    OpenAIRE

    Savage, Jason W.; Patel, Alpesh A.

    2014-01-01

    Study Design Literature review. Objective To discuss the evaluation and management of fixed sagittal plane imbalance. Methods A comprehensive literature review was performed on the preoperative evaluation of patients with sagittal plane malalignment, as well as the surgical strategies to address sagittal plane deformity. Results Sagittal plane imbalance is often caused by de novo scoliosis or iatrogenic flat back deformity. Understanding the etiology and magnitude of sagittal malalignment is ...

  13. HDU Pressurized Excursion Module (PEM) Prototype Systems Integration

    Science.gov (United States)

    Gill, Tracy R.; Kennedy, Kriss; Tri, Terry; Toups, Larry; Howe, A. Scott

    2010-01-01

    The Habitat Demonstration Unit (HDU) project team constructed an analog prototype lunar surface laboratory called the Pressurized Excursion Module (PEM). The prototype unit subsystems were integrated in a short amount of time, utilizing a skunk-works approach that brought together over 20 habitation-related technologies from a variety of NASA centers. This paper describes the system integration strategies and lessons learned, that allowed the PEM to be brought from paper design to working field prototype using a multi-center team. The system integration process included establishment of design standards, negotiation of interfaces between subsystems, and scheduling fit checks and installation activities. A major tool used in integration was a coordinated effort to accurately model all the subsystems using CAD, so that conflicts were identified before physical components came together. Some of the major conclusions showed that up-front modularity that emerged as an artifact of construction, such as the eight 45 degree "pie slices" making up the module whose steel rib edges defined structural mounting and loading points, dictated much of the configurational interfaces between the major subsystems and workstations. Therefore, 'one of the lessons learned included the need to use modularity as a tool for organization in advance, and to work harder to prevent non-critical aspects of the platform from dictating the modularity that may eventually inform the fight system.

  14. Scope Complexity Options Risks Excursions (SCORE) Factor Mathematical Description.

    Energy Technology Data Exchange (ETDEWEB)

    Gearhart, Jared Lee [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Samberson, Jonell Nicole [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Shettigar, Subhasini [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jungels, John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Welch, Kimberly M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jones, Dean A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-03-01

    The purpose of the Scope, Complexity, Options, Risks, Excursions (SCORE) model is to estimate the relative complexity of design variants of future warhead options, resulting in scores. SCORE factors extend this capability by providing estimates of complexity relative to a base system (i.e., all design options are normalized to one weapon system). First, a clearly defined set of scope elements for a warhead option is established. The complexity of each scope element is estimated by Subject Matter Experts (SMEs), including a level of uncertainty, relative to a specific reference system. When determining factors, complexity estimates for a scope element can be directly tied to the base system or chained together via comparable scope elements in a string of reference systems that ends with the base system. The SCORE analysis process is a growing multi-organizational Nuclear Security Enterprise (NSE) effort, under the management of the NA-12 led Enterprise Modeling and Analysis Consortium (EMAC). Historically, it has provided the data elicitation, integration, and computation needed to support the out-year Life Extension Program (LEP) cost estimates included in the Stockpile Stewardship Management Plan (SSMP).

  15. Lichenological excursion In North Africa. I. Silicicolous lichens in Morocco

    Directory of Open Access Journals (Sweden)

    Egea, J. M.

    1988-01-01

    Full Text Available This work summarizes the first floristic results of a lichenologic excursion through some representative localities of Morocco. From the 110 silicicolous species recognized, 42 are, after our information, new to Morocco. Synonymy of 2 taxa is established: Pertusaria ludovicae R. G. Werner = P. ceuthocarpoides Zahlbr. and Pertusaria rupícola (Fr. Harm. var. bispora R. G. Werner = Pertusaria gallica B. de Lesd. These two last species are lectotypified.

    Este trabajo contiene los primeros resultados florísticos de la excursión realizada a algunos puntos representativos de Marruecos. Se citan 110 táxones de líquenes de rocas ácidas, de los cuales 42 son, según nuestros datos, nuevas citas para Marruecos. Se sinonimizan dos táxones: Pertusaria ludovicae R. G. Werner = P. ceuthocarpoides Zahlbr. y Pertusaria rupícola (Fr. Harm. var. bispora R. G. Werner = Pertusaria gallica B. de Lesd. Para cada uno de ellos se designa un lectótipo.

  16. Echocardiographic quantification of systolic function during atrial fibrillation

    DEFF Research Database (Denmark)

    Olsen, Flemming Javier; Jørgensen, Peter Godsk; Dons, Maria;

    2016-01-01

    It is often difficult to provide an exact echocardiographic measure of left ventricular systolic function in patients with atrial fibrillation, partly because of the varying cycle length affecting pre and afterload and partly because of the increased heart rate often accompanying this arrhythmia....... We sought to elucidate two points: whether it would be possible to correct for the cyclic variance in systolic output, and if global longitudinal strain is preferable to the left ventricular ejection fraction at evaluating systolic function during atrial fibrillation....

  17. Two Possible but Unconfirmed Palaeomagnetic Excursions in Pleistocene Lacustrine Sediments in North America and Mexico

    Science.gov (United States)

    Liddicoat, J.; Coe, R.; Oviatt, J.

    2012-04-01

    The palaeomagnetic literature is replete with reports of investigations of continuous field behaviour (secular variation) using volcanic rocks and lacustrine and marine sediments, and some of the reports are about palaeomagnetic excursions. The Laschamp Excursion in volcanic rocks in the Massif Central of France (Bonhommet and Babkine, 1967) and Mono Lake Excursion in exposed lacustrine sediment in California (Denham and Cox, 1971) are two excursions that generally are accepted as having occurred in the late Pleistocene. At other localities and for different time intervals, confirmation of some excursions in sediment has not been successful at nearby sites where the deposits are believed to be the same age. An example is in the Basin of Mexico at Tlapacoya (19.4˚ N, 261.2˚ E) in lacustrine sediments about 14,500 years old (Liddicoat et al., 1979). Another excursion that has not been confirmed but might have occurred is recorded in Lake Bonneville sediments that are exposed in the bank of the Sevier River near Delta, Utah (39.4˚ N, 247.6˚ E). In Mexico and Utah, the excursions are in a single, fully-oriented hand sample that was prepared into consecutive, 2-cm-thick horizons, each consisting of six subsamples. The subsamples were demagnetized in an alternating field to at least 60 mT or when possible because of consolidation, thermally demagnetized to 600˚ C; for each Lake Bonneville horizon, the scatter of palaeomagnetic directions is 4˚ or less. Several possibilities for why the excursion at Tlapacoya could not be confirmed were presented (Liddicoat et al., 1979), leaving open the possibility that the excursion might have occurred in Mexico. The field behaviour in Utah where the sediments are older than those at Tlapacoya by several tens of thousands of years (Oviatt et al., 1994) is nearly identical to the behaviour recorded at Tlapacoya. At both localities, a path of the Virtual Geomagnetic Poles during the excursion is confined to a narrow meridional zone

  18. Two Possible but Unconfirmed Paleomagnetic Excursions in Pleistocene Lacustrine Sediments in North America and Mexico

    Science.gov (United States)

    Liddicoat, J. C.

    2011-12-01

    The paleomagnetic literature is replete with reports of investigations of continuous field behavior (secular variation) using volcanic rocks and lacustrine and marine sediments from around the globe, and some of the reports are about paleomagnetic excursions. The Laschamp Excursion in volcanic rocks in the Massif Central of France (Bonhommet and Babkine, 1967) and Mono Lake Excursion in exposed lacustrine sediment in California (Denham and Cox, 1971) are two excursions that are recognized. At other localities and for different time intervals, confirmation of some excursions in sediment has not been successful at nearby sites where the deposits are believed to be the same age. An example is in the Basin of Mexico at Tlapacoya (19.4 N, 261.2 E)(Liddicoat et al., 1979). Another excursion that has not been confirmed but might have occurred is recorded in Pleistocene Lake Bonneville sediments that are exposed in the bank of the Sevier River near Delta, Utah (39.4 N, 247.6 E). In Mexico and Utah, the excursion is in a single, fully-oriented hand sample that was prepared into consecutive, 2-cm-thick horizons. Each horizon contains six samples that were demagnetized in an alternating field, and for each Lake Bonneville horizon the scatter of directions is 4 degrees or less. Several possibilities for why the excursion at Tlapacoya could not be confirmed were presented (Liddicoat et al., 1979), leaving open the possibility that the excursion might have occurred in Mexico about 14,500 years ago. The field behavior in Utah where the sediments are older than those at Tlapacoya by several tens of thousands of years (Oviatt et al., 1994) is nearly identical to the behavior recorded at Tlapacoya. At both localities, a path of the Virtual Geomagnetic Poles during the excursion is confined to a narrow meridional zone centered at about 200 E longitude and that descends to about 15 N latitude. The difficulty of confirming the anomalous field behavior at Tlapacoya and in Utah

  19. Spatial and temporal patterns of subtidal and intertidal crabs excursions

    Science.gov (United States)

    Silva, A. C. F.; Boaventura, D. M.; Thompson, R. C.; Hawkins, S. J.

    2014-01-01

    Highly mobile predators such as fish and crabs are known to migrate from the subtidal zone to forage in the intertidal zone at high-tide. The extent and variation of these habitat linking movements along the vertical shore gradient have not been examined before for several species simultaneously, hence not accounting for species interactions. Here, the foraging excursions of Carcinus maenas (L.), Necora puber (Linnaeus, 1767) and Cancer pagurus (Linnaeus, 1758) were assessed in a one-year mark-recapture study on two replicated rocky shores in southwest U.K. A comparison between the abundance of individuals present on the shore at high-tide with those present in refuges exposed at low-tide indicated considerable intertidal migration by all species, showing strong linkage between subtidal and intertidal habitats. Estimates of population size based on recapture of marked individuals indicated that an average of ~ 4000 individuals combined for the three crab species, can be present on the shore during one tidal cycle. There was also a high fidelity of individuals and species to particular shore levels. Underlying mechanisms for these spatial patterns such as prey availability and agonistic interactions are discussed. Survival rates were estimated using the Cormack-Jolly-Seber model from multi-recapture analysis and found to be considerably high with a minimum of 30% for all species. Growth rates were found to vary intraspecifically with size and between seasons. Understanding the temporal and spatial variations in predation pressure by crabs on rocky shores is dependent on knowing who, when and how many of these commercially important crab species depend on intertidal foraging. Previous studies have shown that the diet of these species is strongly based on intertidal prey including key species such as limpets; hence intertidal crab migration could be associated with considerable impacts on intertidal assemblages.

  20. A global deglacial negative carbon isotope excursion in speleothem calcite

    Science.gov (United States)

    Breecker, D.

    2015-12-01

    δ13C values of speleothem calcite decreased globally during the last deglaciation defining a carbon isotope excursion (CIE) despite relatively constant δ13C values of carbon in the ocean-atmosphere system. The magnitude of the CIE varied with latitude, increasing poleward from ~2‰ in the tropics to as much as 7‰ at high latitudes. This recent CIE provides an interesting comparison with CIEs observed in deep time. A substantial portion of this CIE can be explained by the increase in atmospheric pCO2 that accompanied deglaciation. The dependence of C3 plant δ13C values on atmospheric pCO2 predicts a 2‰ δ13C decrease driven by the deglacial pCO2 increase. I propose that this signal was transferred to caves and thus explains nearly 100% of the CIE magnitude observed in the tropics and no less than 30% at the highest latitudes in the compilation. An atmospheric pCO2 control on speleothem δ13C values, if real, will need to be corrected for using ice core data before δ13C records can be interpreted in a paleoclimate context. The decrease in the magnitude of the equilibrium calcite-CO2 carbon isotope fractionation factor explains a maximum of 1‰ of the CIE at the highest northern latitude in the compilation, which experienced the largest deglacial warming. Much of the residual extratropical CIE was likely driven by increasing belowground respiration rates, which were presumably pronounced at high latitudes as glacial retreat exposed fresh surfaces and/or vegetation density increased. The largest increases in belowground respiration would have therefore occurred at the highest latitudes, explaining the meridional trend. This work supports the notion that increases in atmospheric pCO2 and belowground respiration rates can result in large CIEs recorded in terrestrial carbonates, which, as previously suggested, may explain the magnitude of the PETM CIE as recorded by paleosol carbonates.

  1. How gravity and muscle action control mediolateral center of mass excursion during slow walking: a simulation study.

    Science.gov (United States)

    Jansen, Karen; De Groote, Friedl; Duysens, Jacques; Jonkers, Ilse

    2014-01-01

    Maintaining mediolateral (ML) balance is very important to prevent falling during walking, especially at very slow speeds. The effect of walking speed on support and propulsion of the center of mass (COM) has been focus of previous studies. However, the influence of speed on ML COM control and the associated coupling with sagittal plane control remains unclear. Simulations of walking at very slow and normal speeds were generated for twelve healthy subjects. Our results show that gluteus medius (GMED) contributions to ML stability decrease, while its contributions to sagittal plane accelerations increase during very slow compared to normal walking. Simultaneously the destabilizing influence of gravity increases in ML direction at a very slow walking speed. This emphasizes the need for a tight balance between gravity and gluteus medius action to ensure ML stability. When walking speed increases, GMED has a unique role in controlling ML acceleration and therefore stabilizing ML COM excursion. Contributions of other muscles decrease in all directions during very slow speed. Increased contributions of these muscles are therefore required to provide for both stability and propulsion when walking speed increases. Copyright © 2013 Elsevier B.V. All rights reserved.

  2. Ulnar nerve excursion and strain at the elbow and wrist associated with upper extremity motion.

    Science.gov (United States)

    Wright, T W; Glowczewskie, F; Cowin, D; Wheeler, D L

    2001-07-01

    Significant excursion of the ulnar nerve is required for unimpeded upper extremity motion. This study evaluated the excursion necessary to accommodate common motions of daily living and associated strain on the ulnar nerve. The 2 most common sites of nerve entrapment, the cubital tunnel and the entrance of Guyon's canal, were studied. Five fresh-frozen, thawed transthoracic cadaver specimens (10 arms) were dissected and the nerve was exposed at the elbow and wrist only enough to be marked with a microsuture. Excursion was measured with a laser mounted on a Vernier caliper fixed to the bone and aligned in the direction of nerve motion. A Microstrain (Burlington, VT) DVRT strain device was applied to the nerve at both the elbow and wrist. Nerve excursion associated with motion of the shoulder, elbow, wrist, and fingers (measured by goniometer) was measured at the wrist and elbow. An average of 4.9 mm ulnar nerve excursion was required at the elbow to accommodate shoulder motion from 30 degrees to 110 degrees of abduction, and 5.1 mm was needed for elbow motion from 10 degrees to 90 degrees. When the wrist was moved from 60 degrees of extension to 65 degrees of flexion, 13.6 mm excursion of the ulnar nerve was required at the wrist. When all the motions of the wrist, fingers, elbow, and shoulder were combined, 21.9 mm of ulnar nerve excursion was required at the elbow and 23.2 mm at the wrist. Ulnar nerve strain of 15% or greater was experienced at the elbow with elbow flexion and at the wrist with wrist extension and radial deviation. Any factor that limits excursion at these sites could result in repetitive traction of the nerve and possibly play a role in the pathophysiology of cubital tunnel syndrome or ulnar neuropathy at Guyon's canal.

  3. Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure

    DEFF Research Database (Denmark)

    Køber, Lars; Thune, Jens J; Nielsen, Jens C

    2016-01-01

    BACKGROUND: The benefit of an implantable cardioverter-defibrillator (ICD) in patients with symptomatic systolic heart failure caused by coronary artery disease has been well documented. However, the evidence for a benefit of prophylactic ICDs in patients with systolic heart failure that is not d...... by Medtronic and others; DANISH ClinicalTrials.gov number, NCT00542945 .)....

  4. Exercise training in older patients with systolic heart failure

    DEFF Research Database (Denmark)

    Prescott, Eva; Hjardem-Hansen, Rasmus; Dela, Flemming

    2009-01-01

    Training improves exercise capacity in patients with heart failure (CHF) but most evidence is on selected younger patients with systolic CHF.......Training improves exercise capacity in patients with heart failure (CHF) but most evidence is on selected younger patients with systolic CHF....

  5. Systolic array IC for genetic computation

    Science.gov (United States)

    Anderson, D.

    1991-01-01

    Measuring similarities between large sequences of genetic information is a formidable task requiring enormous amounts of computer time. Geneticists claim that nearly two months of CRAY-2 time are required to run a single comparison of the known database against the new bases that will be found this year, and more than a CRAY-2 year for next year's genetic discoveries, and so on. The DNA IC, designed at HP-ICBD in cooperation with the California Institute of Technology and the Jet Propulsion Laboratory, is being implemented in order to move the task of genetic comparison onto workstations and personal computers, while vastly improving performance. The chip is a systolic (pumped) array comprised of 16 processors, control logic, and global RAM, totaling 400,000 FETS. At 12 MHz, each chip performs 2.7 billion 16 bit operations per second. Using 35 of these chips in series on one PC board (performing nearly 100 billion operations per second), a sequence of 560 bases can be compared against the eventual total genome of 3 billion bases, in minutes--on a personal computer. While the designed purpose of the DNA chip is for genetic research, other disciplines requiring similarity measurements between strings of 7 bit encoded data could make use of this chip as well. Cryptography and speech recognition are two examples. A mix of full custom design and standard cells, in CMOS34, were used to achieve these goals. Innovative test methods were developed to enhance controllability and observability in the array. This paper describes these techniques as well as the chip's functionality. This chip was designed in the 1989-90 timeframe.

  6. Head excursion of restrained human volunteers and hybrid III dummies in steady state rollover tests.

    Science.gov (United States)

    Moffatt, Edward; Hare, Barry; Hughes, Raymond; Lewis, Lance; Iiyama, Hiroshi; Curzon, Anne; Cooper, Eddie

    2003-01-01

    Seatbelts provide substantial benefits in rollover crashes, yet occupants still receive head and neck injuries from contacting the vehicle roof interior when the roof exterior strikes the ground. Prior research has evaluated rollover restraint performance utilizing anthropomorphic test devices (dummies), but little dynamic testing has been done with human volunteers to learn how they move during rollovers. In this study, the vertical excursion of the head of restrained dummies and human subjects was measured in a vehicle being rotated about its longitudinal roll axis at roll rates from 180-to-360 deg/sec and under static inversion conditions. The vehicle's restraint design was the commonly used 3-point seatbelt with continuous loop webbing and a sliding latch plate. This paper presents an analysis of the observed occupant motion and provides a comparison of dummy and human motion under similar test conditions. Thirty-five tests (eighteen static and seventeen dynamic) were completed using two different sizes of dummies and human subjects in both near and far-side roll directions. The research indicates that far-side rollovers cause the restrained test subjects to have greater head excursion than near-side rollovers, and that static inversion testing underestimates head excursion for far-side occupants. Human vertical head excursion of up to 200 mm was found at a roll rate of 220 deg/sec. Humans exhibit greater variability in head excursion in comparison to dummies. Transfer of seatbelt webbing through the latch plate did not correlate directly with differences in head excursion.

  7. Late Ordovician (Turinian-Chatfieldian) carbon isotope excursions and their stratigraphic and paleoceanographic significance

    Science.gov (United States)

    Ludvigson, Greg A.; Witzke, B.J.; Gonzalez, Luis A.; Carpenter, S.J.; Schneider, C.L.; Hasiuk, F.

    2004-01-01

    Five positive carbon isotope excursions are reported from Platteville-Decorah strata in the Upper Mississippi Valley. All occur in subtidal carbonate strata, and are recognized in the Mifflin, Grand Detour, Quimbys Mill, Spechts Ferry, and Guttenberg intervals. The positive carbon isotope excursions are developed in a Platteville-Decorah succession in which background ??13C values increase upward from about -2??? at the base to about 0??? Vienna Pee Dee belemnite (VPDB) at the top. A regional north-south ??13C gradient, with lighter values to the north and heavier values to the south is also noted. Peak excursion ??13C values of up to +2.75 are reported from the Quimbys Mill excursion, and up to +2.6 from the Guttenberg excursion, although there are considerable local changes in the magnitudes of these events. The Quimbys Mill, Spechts Ferry, and Guttenberg carbon isotope excursions occur in units that are bounded by submarine disconformities, and completely starve out in deeper, more offshore areas. Closely spaced chemostratigraphic profiles of these sculpted, pyrite-impregnated hardground surfaces show that they are associated with very abrupt centimeter-scale negative ??13C shifts of up to several per mil, possibly resulting from the local diagenetic effects of incursions of euxinic bottom waters during marine flooding events. ?? 2004 Elsevier B.V. All rights reserved.

  8. Statistical analysis of simulation-generated time series : Systolic vs. semi-systolic correlation on the Connection Machine

    NARCIS (Netherlands)

    Dontje, T.; Lippert, Th.; Petkov, N.; Schilling, K.

    1992-01-01

    Autocorrelation becomes an increasingly important tool to verify improvements in the state of the simulational art in Latice Gauge Theory. Semi-systolic and full-systolic algorithms are presented which are intensively used for correlation computations on the Connection Machine CM-2. The semi-systoli

  9. Statistical analysis of simulation-generated time series : Systolic vs. semi-systolic correlation on the Connection Machine

    NARCIS (Netherlands)

    Dontje, T.; Lippert, Th.; Petkov, N.; Schilling, K.

    1992-01-01

    Autocorrelation becomes an increasingly important tool to verify improvements in the state of the simulational art in Latice Gauge Theory. Semi-systolic and full-systolic algorithms are presented which are intensively used for correlation computations on the Connection Machine CM-2. The

  10. Evaluation of cardiac longitudinal systolic function in patients with heart transplant using two dimensional speckle tracking echocardiography and tissue Doppler imaging%二维斑点追踪及组织多普勒技术评价移植心脏纵向收缩功能的临床研究

    Institute of Scientific and Technical Information of China (English)

    李政; 潘翠珍; 舒先红; 陈昊; 王春生

    2014-01-01

    目的 应用二维斑点追踪技术及组织多普勒技术分别评价移植心脏左、右室纵向收缩功能.方法 56例心脏移植患者,根据心内膜心肌活检及长期临床随访结果分为无排异组(A组)和排异组(B组),随机入选36例健康志愿者归入C组,测量左室射血分数(LVEF)、肺动脉收缩压、三尖瓣瓣环位移(TAPSE)和三尖瓣瓣环收缩期速度(TA-S')等指标.应用Qlab 9.0软件分析获得左室整体纵向应变值(global longitudinal strain,GLS).结果 B组较C组LVEF降低(P<0.01).三组间GLS、TAPSE及TA-S'值比较差异均有统计学意义(P均<0.01),B组<A组<C组;GLS与LVEF、TAPSE、TA-S'有较好的负相关性(r分别为-0.64,-0.69,-0.71,P均<0.01).结论 心脏移植患者左、右室纵向收缩功能均有不同程度降低.%Objective To investigate longitudinal systolic function of transplanted heart using two dimensional speckle tracking echocardiography and tissue Doppler imaging.Methods 56 consecutive patients with heart transplant were recruited,according to myocardial biopsy and 1 year's follow up,they were divided into non-rejection group (group A) and rejection group (group B).36 healthy controls (group C) were also randomly recruited.Left ventricular ejection fraction (LVEF),pulmonary arterial systolic pressure,tricuspid annular plane systolic excursion (TAPSE),tricuspid annular plane systolic velocity (TAS') and global longitudinal strain (GLS) were calculated via Qlab 9.0 analysis software offline.Results Compared with group C,LVEF was reduced in group B (P <0.01).Differences of GLS,TAPSE,and TA-S' among groups were all statistically significant (P <0.01),group B<group A< group C.LVEF,TAPSE and TA-S' were correlated with GLS (r =-0.64,r =-0.69,r =-0.71 ; all P < 0.01).Conclusions Left and right ventricles were a functional unity,the systolic function of which was impaired in patients with heart transplant.

  11. Ultrasonographic assessment of flexor tendon mobilization: effect of different protocols on tendon excursion.

    Science.gov (United States)

    Korstanje, Jan-Wiebe H; Soeters, Johannes N M; Schreuders, Ton A R; Amadio, Peter C; Hovius, Steven E R; Stam, Henk J; Selles, Ruud W

    2012-03-07

    Different mobilization protocols have been proposed for rehabilitation after hand flexor tendon repair to provide tendon excursion sufficient to prevent adhesions. Several cadaver studies have shown that the position of the neighboring fingers influences tendon excursions of the injured finger. We hypothesized that the positions of adjacent fingers influence the long finger flexor digitorum profundus tendon excursion, measured both absolutely and relative to the surrounding tissue of the tendon. Long finger flexor digitorum profundus tendon excursions and surrounding tissue movement were measured in zone V in eleven healthy subjects during three different rehabilitation protocols and two experimental models: (1) an active four-finger mobilization protocol, (2) a passive four-finger mobilization protocol, (3) a modified Kleinert mobilization protocol, (4) an experimental modified Kleinert flexion mobilization model, and (5) an experimental modified Kleinert extension mobilization model. Tendon excursions were measured with use of a frame-to-frame analysis of high-resolution ultrasound images. The median absolute long finger flexor digitorum profundus tendon excursions were 23.4, 17.8, 10.0, 13.9, and 7.6 mm for the active four-finger mobilization protocol, the passive four-finger mobilization protocol, the modified Kleinert mobilization protocol, the experimental modified Kleinert flexion mobilization model, and the experimental modified Kleinert extension mobilization model, respectively, and these differences were all significant (p ≤ 0.041). The corresponding relative flexor digitorum profundus tendon excursions were 11.2, 8.5, 7.2, 10.4, and 5.6 mm. Active four-finger mobilization protocol excursions were significantly (p = 0.013) greater than passive four-finger mobilization protocol excursions but were not significantly greater than experimental modified Kleinert flexion mobilization model excursions (p =0.213). The present study demonstrated large and

  12. Unitals in Projective Planes

    CERN Document Server

    Barwick, Susan

    2008-01-01

    Unitals are key structures in projective planes, and have connections with other structures in algebra. This book presents a monograph on unitals embedded in finite projective planes. It offers a survey of the research literature on embedded unitals. It is suitable for graduate students and researchers who want to learn about this topic

  13. Efficacy of combination therapy for systolic blood pressure in patients with severe systolic hypertension: the Systolic Evaluation of Lotrel Efficacy and Comparative Therapies (SELECT) study.

    Science.gov (United States)

    Neutel, Joel M; Smith, David H G; Weber, Michael A; Schofield, Lesley; Purkayastha, Das; Gatlin, Marjorie

    2005-11-01

    Systolic hypertension is predominant among patients over 50 years of age, is a more important cardiovascular risk factor than diastolic blood pressure, and is more difficult to control than diastolic blood pressure. Consequently, the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) recommends combination therapy as first-line treatment for patients with stage 2 hypertension. In the Systolic Evaluation of Lotrel Efficacy and Comparative Therapies (SELECT) study, 24-hour ambulatory blood pressure monitoring was used to identify patients with systolic hypertension and to determine the impact of 8 weeks of treatment with either amlodipine besylate/benazepril HCl 5/20 mg combination therapy (n=149), amlodipine besylate 5 mg (n=146), or benazepril HCl 20 mg (n=148). Combination therapy was significantly more effective in reducing systolic blood pressure and pulse pressure than either monotherapy (pamlodipine-treated group. The combination of amlodipine besylate/benazepril HCl given to patients with stage 2 systolic hypertension resulted in significantly greater reductions in blood pressure and pulse pressure than those seen with monotherapy and was at least as well tolerated as the separate components. This data supports the recommendation of the JNC 7 for the use of combination therapy in patients with stage 2 hypertension.

  14. Multi-proxy identification of the Laschamp geomagnetic field excursion in Lake Pupuke, New Zealand

    Science.gov (United States)

    Nilsson, Andreas; Muscheler, Raimund; Snowball, Ian; Aldahan, Ala; Possnert, Göran; Augustinus, Paul; Atkin, Daniel; Stephens, Tom

    2011-11-01

    We present palaeomagnetic and cosmogenic radionuclide records of the Laschamp geomagnetic excursion in Lake Pupuke, a maar lake in Auckland, New Zealand. Laschamp was identified by a combination of relative palaeointensity, 10Be and 14C data from the lake sediments and represents the first such record from the Southern Hemisphere. Despite the high organic carbon content, which causes relatively weak natural remanent magnetisations, the geomagnetic intensity minimum associated with the Laschamp excursion is identifiable as a relative palaeointensity minimum that is synchronous with (i) a peak in 10Be concentration and (ii) an anomaly in Δ 14C. The Lake Pupuke time scale, provided by 14C data calibrated with INTCAL09, places the 10Be maximum at the same time as a 10Be maximum in Greenland ice cores when secured to the GICC05 time scale. The central age of the Laschamp geomagnetic excursion in Lake Pupuke as defined by the 10Be prediction peak is c. 41 kyr, which confirms its global application as a palaeomagnetic isochron. Anomalous palaeomagnetic directional data at c. 32 kyr in the Lake Pupuke sediments may represent the Mono Lake geomagnetic excursion, but tephra layers caused by frequent eruptions in the Auckland volcanic field during this excursion probably disrupted the palaeointensity signal. The study highlights the value of combining traditional palaeomagnetic methods with measurements of cosmogenic radionuclides in the quest for accurate and precise geochronologies during MIS3, a time of rapid global climate change.

  15. Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure

    DEFF Research Database (Denmark)

    Køber, Lars; Thune, Jens J; Nielsen, Jens C

    2016-01-01

    BACKGROUND: The benefit of an implantable cardioverter-defibrillator (ICD) in patients with symptomatic systolic heart failure caused by coronary artery disease has been well documented. However, the evidence for a benefit of prophylactic ICDs in patients with systolic heart failure that is not due.......6%) in the control group (P=0.29). CONCLUSIONS: In this trial, prophylactic ICD implantation in patients with symptomatic systolic heart failure not caused by coronary artery disease was not associated with a significantly lower long-term rate of death from any cause than was usual clinical care. (Funded...... to coronary artery disease has been based primarily on subgroup analyses. The management of heart failure has improved since the landmark ICD trials, and many patients now receive cardiac resynchronization therapy (CRT). METHODS: In a randomized, controlled trial, 556 patients with symptomatic systolic heart...

  16. Low-Level and Successive Large-Level Excursions of a Stationary Gaussian Process

    CERN Document Server

    Nguyen, Van Minh

    2012-01-01

    The present work investigates two properties of level crossings of a stationary Gaussian process $X(t)$ with autocorrelation function $R_X(\\tau)$. We show firstly that if $R_X(\\tau)$ admits finite second and fourth derivatives at the origin, the length of up-excursions above a low level $-\\gamma$ is asymptotically exponential as $-\\gamma \\to -\\infty$. Secondly, assume that $R_X(\\tau)$ admits a finite second derivative at the origin and some defined properties, we derive the mean number of crossings as well as the length of successive excursions above two adjacent large levels. The asymptotic results are showed to be effective even for practical values of crossing levels. An application of the developed results is proposed to derive the probability of successive excursions above adjacent levels during a time window.

  17. Shapes and Sizes of Voids in the LCDM Universe: Excursion Set Approach

    CERN Document Server

    Shandarin, S; Heitmann, K; Habib, S; Shandarin, Sergei; Feldman, Hume A.; Heitmann, Katrin

    2006-01-01

    We study the global distribution and morphology of dark matter voids in a LCDM universe using density fields generated by N-body simulations. Voids are defined as isolated regions of the low-density excursion set specified via density thresholds, the density thresholds being quantified by the corresponding filling factors, i.e., the fraction of the total volume in the excursion set. Our work encompasses a systematic investigation of the void volume function, the volume fraction in voids, and the fitting of voids to corresponding ellipsoids and spheres. We emphasize the relevance of the percolation threshold to the void volume statistics of the density field both in the high redshift, Gaussian random field regime, as well as in the present epoch. By using measures such as the Inverse Porosity, we characterize the quality of ellipsoidal fits to voids, finding that such fits are a poor representation of the larger voids that dominate the volume of the void excursion set.

  18. No apparent lock-in depth of the Laschamp geomagnetic excursion: Evidence from the Malan loess

    Institute of Scientific and Technical Information of China (English)

    ZHU Rixiang; LIU Qingsong; PAN Yongxin; DENG Chenglong; ZHANG Rui; WANG Xianfeng

    2006-01-01

    The first-order chronological framework of the long-term Chinese loess/paleosol sequences was based mainly on magnetostratigraphy. However, there remain arguments on the lock-in ages of the major geomagnetic reversals. This study systematically compared the stratigraphic locations of the Laschamp excursion and Henrich events (H4 at~39 ka and H5 at~48 ka) recorded by the Luochuan loess profile in the central Chinese Loess Plateau. Results show that the Lascchamp excursion is bracketed well by these two cold events, and the corresponding estimated age is between about 41.7-43.7 ka, which is close to the widely accepted age of ~40-41 ka for the excursion.Therefore, our new results do not suggest apparent lock-in effects in the last glacial Malan loess.

  19. Fixed sagittal plane imbalance.

    Science.gov (United States)

    Savage, Jason W; Patel, Alpesh A

    2014-12-01

    Study Design Literature review. Objective To discuss the evaluation and management of fixed sagittal plane imbalance. Methods A comprehensive literature review was performed on the preoperative evaluation of patients with sagittal plane malalignment, as well as the surgical strategies to address sagittal plane deformity. Results Sagittal plane imbalance is often caused by de novo scoliosis or iatrogenic flat back deformity. Understanding the etiology and magnitude of sagittal malalignment is crucial in realignment planning. Objective parameters have been developed to guide surgeons in determining how much correction is needed to achieve favorable outcomes. Currently, the goals of surgery are to restore a sagittal vertical axis Sagittal plane malalignment is an increasingly recognized cause of pain and disability. Treatment of sagittal plane imbalance varies according to the etiology, location, and severity of the deformity. Fixed sagittal malalignment often requires complex reconstructive procedures that include osteotomy correction. Reestablishing harmonious spinopelvic alignment is associated with significant improvement in health-related quality-of-life outcome measures and patient satisfaction.

  20. Volcanic records of the Laschamp geomagnetic excursion from Mt Ruapehu, New Zealand

    Science.gov (United States)

    Ingham, E.; Turner, G. M.; Conway, C. E.; Heslop, D.; Roberts, A. P.; Leonard, G.; Townsend, D.; Calvert, A.

    2017-08-01

    We present palaeodirectional records of the Laschamp geomagnetic excursion from lavas on Mt Ruapehu, New Zealand. Fourteen lava flows on the northwestern and southern flanks of Mt Ruapehu, with 40Ar/39Ar weighted mean plateau ages that range from 46.3 ± 2.0 to 39.9 ± 1.4 ka, were studied. The youngest and older flows carry a normal polarity magnetization; however, six flows, dated between 46.3 ± 2.0 and 42.7 ± 1.8 ka, record excursional directions. Three of these flows record southerly palaeomagnetic declinations and negative inclinations that agree well with a published Laschamp record from the Auckland Volcanic Field (AVF). Together, the AVF and Mt Ruapehu lavas currently represent the only volcanic records of the Laschamp excursion outside the Chaîne des Puys region, France. Thus, they make an important contribution to the global set of Laschamp excursion records. Virtual geomagnetic pole (VGP) groups for the New Zealand and French records early in the excursion are compatible with a dipole-dominated field that rotated to an equatorial orientation while simultaneously decaying in strength. In contrast, younger excursional flows from France and New Zealand yield separate VGP groups, which suggest either that the field had a nondipolar morphology in this later phase, or that the VGP groups were not synchronous. 40Ar/39Ar ages for the Mt Ruapehu record are on average slightly older than published northern hemisphere ages and from the relative palaeointensity minimum in the GLOPIS sedimentary stack. Although few individual ages differ significantly at the 2σ level, the spread suggests an overall excursion duration that is longer than the currently accepted 1500 years. This age spread may result from excess Ar in magmas at the time of the eruption biasing the results to slightly older ages, or from non-synchronous excursional field behaviour at near-antipodal locations, or, possibly, a precursory phase prior to the main excursion.

  1. Correlation between 1,5-anhydroglucitol and glycemic excursions in type 2 diabetic patients

    Institute of Scientific and Technical Information of China (English)

    SUN Jie; DOU Jing-tao; WANG Xian-ling; YANG Guo-qing; L(U) Zhao-hui; ZHENG Hua; MA Fang-ling; LU Ju-ming; MU Yi-ming

    2011-01-01

    Background The accurate and comprehensive assessment of glycemic control in patients with diabetes is important for optimizing glycemic management and for formulating personalized diabetic treatment schemes.This study aimed to analyze the correlation between 1,5-anhydroglucitol (1,5-AG) and glycemic excursions in type 2 diabetic patients.Methods Seventy-one outpatients with type 2 diabetes mellitus were randomly recruited from Chinese People's Liberation Army General Hospital.Using a continuous glucose monitoring system (CGMS),these patients' blood glucose levels were monitored for three consecutive days to obtain mean blood glucose (MBG) data.Intraday glycemic excursions were evaluated using the mean amplitude of glycemic excursions (MAGE),the largest amplitude of glycemic excursions (LAGE),standard deviation of blood glucose (SDBG) and the M-value.Interday glycemic excursion was assessed by absolute mean of daily difference (MODD).Postprandial glycemic fluctuations were evaluated using postprandial glucose excursions (PPGE) and postprandial incremental area under the curve (iAUC).Fasting venous blood samples were collected to measure serum 1,5-AG,whole-blood hemoglobin A1c (HbA1c) and serum glycated albumin (GA).Clinical markers of glycemia and parameters of glycemic excursions from CGMS were analyzed using the Pearson correlation coefficient and multivariate stepwise regression.Results Pearson correlation analysis revealed that 1,5-AG was significantly correlated with MAGE,SDBG,M-value,LAGE,PPGE and iAUC (r values were -0.509,-0.430,-0.530,-0.462,-0.416 and -0.435,respectively,P <0.01),especially in moderately and well-controlled patients,based on defined HbA1c levels.Multivariate stepwise regression analysis revealed a negative correlation between 1,5-AG and the above parameters,but not HbA1c and GA.Finally,HbA1c and GA were positively correlated with MBG and fasting blood glucose (FBG).Conclusions 1,5-AG was much better than HbA1c and GA as a marker of

  2. Identification and dating of the Mono Lake excursion in lava flows from the Canary islands.

    Science.gov (United States)

    Guillou, Hervé; Laj, Carlo; Carracedo, Juan-Carlos; Kissel, Catherine; Nomade, Sebastien; Perez-Torrado, Francisco; Wandres, Camille

    2010-05-01

    The Mono Lake geomagnetic excursion was defined from the study of lacustrine sections from Western North America [Denham, 1974; Liddicoat et al., 1979]. The proposed age for this excursion reported in the literature changed in time since the first observation and a debate was even very recently opened about the reliability of the dating at the original section at Wilson Creek. In ice cores, a peak in the production of cosmogenic isotopes is clearly observed about 7 ka after the peak associated to the Laschamp excursion. This younger peak, attributed to the Mono Lake occurs between the millennial climatic cycles 7 and 6 (Dansgaard-Oeschger cycles), around 34 kyr in the most recent Greenland ice age model. In addition, in other places, this excursion is described by an intensity low with only very rarely an associated directional shift, questioning the global character of this excursion. We present a coupled paleomagnetic and dating investigation conducted on four different lavas from the island of Tenerife (Spain) on the basis of preliminary K/Ar dating. From a paleomagnetic point of view, one of these sites is characterized by a direction largely deviated from the one calculated on the basis of an axial geocentric dipole field. The paleointensity values, determined using Thellier and Thellier method and the PICRIT03 set of criteria, is very low, about 8 µT. Two other sites are slightly deviated from the GAD value, in particular with lower inclinations. Paleointensity determinations from these lavas do not yet have a statistical significance and need to be completed but the first results indicate a value around 20 µT. Finally, the last site has a direction consistent with the GAD values and no reliable paleointensity determinations could be obtained so far. The preliminary K/Ar dating are now completed by Ar/Ar dating and their combination yield an average age of about 32 ka ± 2 ka for the four outcrops, not statistically distinguishable one from another. This

  3. Risser sign: the value of the lateral spinal radiograph to assess the excursion of the iliac apophysis.

    Science.gov (United States)

    Kotwicki, T

    2008-01-01

    The course of the ossification of the iliac apophysis is considered in adolescent patients with idiopathic scoliosis, under the name of the Risser sign, to determine the remaining spinal growth. Although the iliac crest develops in the three-dimensional space as a complex structure, the iliac apophysis ossification has been assessed only on a one plane frontal spinal radiograph. This study points out the usefulness of the lateral radiograph for the visualization of the whole iliac crest, especially the posterior region which otherwise cannot be observed. Two young female pelvis specimen were examined with anatomical measurements and radiography. Lateral spinal radiographs of 201 girls were analyzed for the iliac apophysis excursion. The measures of the width of the iliac bone beneath the iliac crest revealed one anterior and one posterior thick regions, coupled with an intermediate thin region. The regions of the maximal thickness corresponded to the earliest appearance of the apophysis ossification (Risser 1), while the thin part of the iliac bone corresponded to late appearance of the apophysis ossification (Risser 3-4). The ossification of the posterior part of the crest was best visualized with the lateral radiograph, which was exclusive in showing the posterior superior iliac spine region. On the frontal spinal radiograph the end of the course of the apophysis (Risser 3-4) is usually searched at the level of the sacroiliac joint, while in reality this point was found to be situated more caudal, and accessible for observation on the lateral radiograph.

  4. Systolic Blood Pressure Intervention Trial (SPRINT) and Target Systolic Blood Pressure in Future Hypertension Guidelines.

    Science.gov (United States)

    Egan, Brent M; Li, Jiexiang; Wagner, C Shaun

    2016-08-01

    The Systolic Blood Pressure (SBP, mm Hg) Intervention Trial (SPRINT) showed that targeting SBP SPRINT has 2 implicit assumptions that could impact future US hypertension guidelines: (1) standard therapy controlled SBP similarly to that in adults with treated hypertension and (2) intensive therapy produced a lower mean SBP than in adults with treated hypertension and SBP SPRINT-like participants aged ≥50 years; group 2 consisted of participants all aged ≥18 years; and group 3 consisted of participants aged ≥18 years excluding group 1 but otherwise similar to SPRINT-like participants except high cardiovascular risk. Mean SBPs in groups 1, 2, and 3 were 133.0, 130.1, and 124.6, with 66.2%, 72.2%, and 81.9%, respectively, controlled to SBP SPRINT-like group had higher mean SBP than comparison groups, yet lower than SPRINT standard treatment group and (2) among groups 1 to 3 with SBP SPRINT intensive treatment. SPRINT results suggest that treatment should be continued and not reduced when treated SBP is SPRINT-like subset. Furthermore, increasing the percentage of treated adults with SBP SPRINT intensive treatment SBP without lowering treatment goals.

  5. Atrial systole enhances intraventricular filling flow propagation during increasing heart rate

    Science.gov (United States)

    Santhanakrishnan, Arvind; Okafor, Ikechukwu; Kumar, Gautam; Yoganathan, Ajit P.

    2016-01-01

    Diastolic fluid dynamics in the left ventricle (LV) has been examined in multiple clinical studies for understanding cardiac function in healthy humans and developing diagnostic measures in disease conditions. The question of how intraventricular filling vortex flow pattern is affected by increasing heart rate (HR) is still unanswered. Previous studies on healthy subjects have shown a correlation between increasing HR and diminished E/A ratio of transmitral peak velocities during early filling (E-wave) to atrial systole (A-wave). We hypothesize that with increasing HR under constant E/A ratio, E-wave contribution to intraventricular vortex propagation is diminished. A physiologic in vitro flow phantom consisting of a LV physical model was used for this study. HR was varied across 70, 100 and 120 beats per minute (bpm) with E/A of 1.1–1.2. Intraventricular flow patterns were characterized using 2D particle image velocimetry measured across three parallel longitudinal (apical-basal) planes in the LV. A pair of counter-rotating vortices was observed during E-wave across all HRs. With increasing HR, diminished vortex propagation occurred during E-wave and atrial systole was found to amplify secondary vorticity production. The diastolic time point where peak vortex circulation occurred was delayed with increasing HR, with peak circulation for 120 bpm occurring as late as 90% into diastole near the end of A-wave. The role of atrial systole is elevated for higher HR due to the limited time available for filling. Our baseline findings and analysis approach can be applied to studies of clinical conditions where impaired exercise tolerance is observed. PMID:26895781

  6. SNAP focal plane

    Energy Technology Data Exchange (ETDEWEB)

    Lampton, Michael L.; Kim, A.; Akerlof, C.W.; Aldering, G.; Amanullah, R.; Astier, P.; Barrelet, E.; Bebek, C.; Bergstrom, L.; Berkovitz, J.; Bernstein, G.; Bester, M.; Bonissent, A.; Bower, C.; Carithers Jr., W.C.; Commins, E.D.; Day, C.; Deustua, S.E.; DiGennaro,R.; Ealet, A.; Ellis, R.S.; Eriksson, M.; Fruchter, A.; Genat, J.-F.; Goldhaber, G.; Goobar, A.; Groom, D.; Harris, S.E.; Harvey, P.R.; Heetderks, H.D.; Holland, S.E.; Huterer, D.; Karcher, A.; Kolbe, W.; Krieger, B.; Lafever, R.; Lamoureux, J.; Levi, M.E.; Levin, D.S.; Linder,E.V.; Loken, S.C.; Malina, R.; Massey, R.; McKay, T.; McKee, S.P.; Miquel, R.; Mortsell, E.; Mostek, N.; Mufson, S.; Musser, J.; Nugent, P.; Oluseyi, H.; Pain, R.; Palaio, N.; Pankow, D.; Perlmutter, S.; Pratt, R.; Prieto, E.; Refregier, A.; Rhodes, J.; Robinson, K.; Roe, N.; Sholl, M.; Schubnell, M.; Smadja, G.; Smoot, G.; Spadafora, A.; Tarle, G.; Tomasch,A.; von der Lippe, H.; Vincent, R.; Walder, J.-P.; Wang, G.

    2002-07-29

    The proposed SuperNova/Acceleration Probe (SNAP) mission will have a two-meter class telescope delivering diffraction-limited images to an instrumented 0.7 square-degree field sensitive in the visible and near-infrared wavelength regime. We describe the requirements for the instrument suite and the evolution of the focal plane design to the present concept in which all the instrumentation--visible and near-infrared imagers, spectrograph, and star guiders--share one common focal plane.

  7. Maximum Acceptable Vibrato Excursion as a Function of Vibrato Rate in Musicians and Non-musicians

    DEFF Research Database (Denmark)

    Vatti, Marianna; Santurette, Sébastien; Pontoppidan, Niels H.

    and, in most listeners, exhibited a peak at medium vibrato rates (5–7 Hz). Large across-subject variability was observed, and no significant effect of musical experience was found. Overall, most listeners were not solely sensitive to the vibrato excursion and there was a listener-dependent rate...

  8. Maximum Acceptable Vibrato Excursion as a Function of Vibrato Rate in Musicians and Non-musicians

    DEFF Research Database (Denmark)

    Vatti, Marianna; Santurette, Sébastien; Pontoppidan, Niels H.

    2014-01-01

    and, in most listeners, exhibited a peak at medium vibrato rates (5–7 Hz). Large across-subject variability was observed, and no significant effect of musical experience was found. Overall, most listeners were not solely sensitive to the vibrato excursion and there was a listener-dependent rate...

  9. The end-Triassic negative δ13C excursion : A lithologic test

    NARCIS (Netherlands)

    Bachan, Aviv; van de Schootbrugge, Bas; Payne, Jonathan L.

    2014-01-01

    The end-Triassic mass extinction is associated with a large negative carbon isotope excursion, which has been interpreted as reflecting the rapid injection of 13C depleted CO2 or methane associated with the emplacement of the Central Atlantic Magmatic Province. However, in a number of sections in ce

  10. Mitigation of grid frequency excursions at hourly transitions by wind power

    Energy Technology Data Exchange (ETDEWEB)

    Haan, Jerom E.S. de; Frunt, Jasper; Kling, Wil L. [Eindhoven Univ. of Technology (Netherlands). Dept. of Electrical Engineering

    2011-07-01

    It has been noticed that grid frequency deviations at hourly transitions of the Continental Europe synchronous area of the ENTO-E (former UCTE) continue to increase. If the system faces a negative grid frequency excursion and meanwhile a large generation outage would occur, system's frequency stability and reliability could be jeopardized. In order to unburden conventional speed control capacity, this paper proposes a concept to support the grid frequency at hourly transitions by utilizing the kinetic energy stored in wind turbines. On request, kinetic energy will be stored in or released from wind turbines in order to respectively absorb or supply energy to the system. The performance of 8 GW of aggregated offshore wind power in the North Sea is analyzed for the Netherlands. The research shows that if the Netherlands had to provide their share of speed control to limit negative grid frequency excursions to a minimum of 49.95 Hz, 8 GW of offshore wind power could fulfill this for a quarter of the time. For positive grid frequency excursions at hourly transitions the Netherlands could use 60% of the time 8 GW of wind power to limit grid frequency excursions to a maximum of 50.05 Hz. (orig.)

  11. Carbon isotope excursions and the oxidant budget of the Ediacaran atmosphere and ocean

    Science.gov (United States)

    Bristow, Thomas F.; Kennedy, Martin J.

    2008-11-01

    A possible global drop in marine carbon isotope values to aslow as -12 Peedee belemnite (PDB), recorded in the EdiacaranShuram Formation of Oman, has been attributed to the non-steady-stateoxidation of oceanic dissolved organic carbon (DOC) resultingfrom the rise in atmospheric oxygen to near modern values atthe end of the Precambrian. Geologic constraints indicate thatthe excursion lasted between 25 and 50 m.y., requiring a DOCpool thousands of times to 10,000 times the modern inventoryto conform with carbon isotope mass balance calculations fora -12 excursion. At the consequent rates of DOC oxidation,oceanic sulfate and oxygen in the atmosphere and oceans areexhausted on a time scale of 800 k.y. Oxidant depletion isincompatible with independent geochemical and biological indicatorsthat show oceanic sulfate and oxygen levels were maintainedor increased during the Shuram excursion. Furthermore, a DOC-drivenexcursion does not explain strong covariation between the carbonand oxygen isotope record. These indicators show that negativeisotope excursions recorded in the Shuram and other Ediacaransections are unlikely to represent a global ocean signal.

  12. Multicultural Group Work on Field Excursions to Promote Student Teachers' Intercultural Competence

    Science.gov (United States)

    Brendel, Nina; Aksit, Fisun; Aksit, Selahattin; Schrüfer, Gabriele

    2016-01-01

    As a response to the intercultural challenges of Geography Education, this study seeks to determine factors fostering intercultural competence of student teachers. Based on a one-week multicultural field excursion of eight German and eight Turkish students in Kayseri (Turkey) on Education for Sustainable Development, we used qualitative interviews…

  13. Geomagnetic excursions recorded in loess: case studies from the Danubian loess province

    NARCIS (Netherlands)

    Hambach, U.; Rolf, C.; Zeeden, C.; Markovic, S.; Jovanovic, M.; Nowaczyk, N.

    2011-01-01

    Geomagnetic excursions are prominent short-lived features (normally < 5 kyr) of the Earth’s magnetic field and lie temporally between Microchrons (Laj & Channell 2007) and short time intervals of anomalously high secular variation. Because of their short duration and the time required for remanence

  14. Multicultural Group Work on Field Excursions to Promote Student Teachers' Intercultural Competence

    Science.gov (United States)

    Brendel, Nina; Aksit, Fisun; Aksit, Selahattin; Schrüfer, Gabriele

    2016-01-01

    As a response to the intercultural challenges of Geography Education, this study seeks to determine factors fostering intercultural competence of student teachers. Based on a one-week multicultural field excursion of eight German and eight Turkish students in Kayseri (Turkey) on Education for Sustainable Development, we used qualitative interviews…

  15. The Carnian (Late Triassic) carbon isotope excursion: new insights from the terrestrial realm

    Science.gov (United States)

    Miller, Charlotte; Kürschner, Wolfram; Peterse, Francien; Baranyi, Viktoria; Reichart, Gert-Jan

    2016-04-01

    The geological record contains evidence for numerous pronounced perturbations in the global carbon cycle, some of which are associated with eruptions from large igneous provinces (LIP), and consequently, ocean acidification and mass extinction. In the Carnian (Late Triassic), evidence from sedimentology and fossil pollen points to a significant change in climate, resulting in biotic turnover: during a period termed the 'Carnian Pluvial Event' (CPE). Additionally, during the Carnian, large volumes of flood basalts were erupted from the Wrangellia LIP (western North America). Evidence from the marine realm suggests a fundamental relationship between the CPE, a global 'wet' period, and the injection of light carbon into the atmosphere from the LIP. Here we provide the first evidence from the terrestrial realm of a significant negative δ13C excursion through the CPE recorded in the sedimentary archive of the Wiscombe Park Borehole, Devon (UK). Both total organic matter and plant leaf waxes reflect a gradual carbon isotope excursion of ~-5‰ during this time interval. Our data provides evidence for the global nature of this isotope excursion, supporting the hypothesis that the excursion was likely the result of an injection of light carbon into the atmosphere from the Wrangellia LIP.

  16. Systolic multipliers for finite fields GF(2 exp m)

    Science.gov (United States)

    Yeh, C.-S.; Reed, I. S.; Truong, T. K.

    1984-01-01

    Two systolic architectures are developed for performing the product-sum computation AB + C in the finite field GF(2 exp m) of 2 exp m elements, where A, B, and C are arbitrary elements of GF(2 exp m). The first multiplier is a serial-in, serial-out one-dimensional systolic array, while the second multiplier is a parallel-in, parallel-out two-dimensional systolic array. The first multiplier requires a smaller number of basic cells than the second multiplier. The second multiplier needs less average time per computation than the first multiplier, if a number of computations are performed consecutively. To perform single computations both multipliers require the same computational time. In both cases the architectures are simple and regular and possess the properties of concurrency and modularity. As a consequence, they are well suited for use in VLSI systems.

  17. Low Power Systolic Array Based Digital Filter for DSP Applications

    Directory of Open Access Journals (Sweden)

    S. Karthick

    2015-01-01

    Full Text Available Main concepts in DSP include filtering, averaging, modulating, and correlating the signals in digital form to estimate characteristic parameter of a signal into a desirable form. This paper presents a brief concept of low power datapath impact for Digital Signal Processing (DSP based biomedical application. Systolic array based digital filter used in signal processing of electrocardiogram analysis is presented with datapath architectural innovations in low power consumption perspective. Implementation was done with ASIC design methodology using TSMC 65 nm technological library node. The proposed systolic array filter has reduced leakage power up to 8.5% than the existing filter architectures.

  18. Low Power Systolic Array Based Digital Filter for DSP Applications.

    Science.gov (United States)

    Karthick, S; Valarmathy, S; Prabhu, E

    2015-01-01

    Main concepts in DSP include filtering, averaging, modulating, and correlating the signals in digital form to estimate characteristic parameter of a signal into a desirable form. This paper presents a brief concept of low power datapath impact for Digital Signal Processing (DSP) based biomedical application. Systolic array based digital filter used in signal processing of electrocardiogram analysis is presented with datapath architectural innovations in low power consumption perspective. Implementation was done with ASIC design methodology using TSMC 65 nm technological library node. The proposed systolic array filter has reduced leakage power up to 8.5% than the existing filter architectures.

  19. The range of excursion of flexor tendons in Zone V: a comparison of active vs passive flexion mobilisation regimes.

    LENUS (Irish Health Repository)

    Panchal, J

    1997-10-01

    A number of early postoperative mobilisation regimes have been developed in an attempt to increase tendon excursion and gliding and thereby reduce formation of adhesions following repair of flexor tendons. Early active flexion mobilisation regimes are becoming more popular, and have replaced early passive flexion regimes in many centres. The aim of the present study was: (a) to determine the range of excursion of flexor tendons in Zone V, and (b) to compare the excursion ranges between active (Belfast) and passive (modified Duran) flexion mobilisation regimes postoperatively. This was done (a) in two cadavers, and (b) in two patients intraoperatively, and postoperatively at 10 days, 3 weeks and 6 weeks. With passive flexion, the mean tendon excursion in Zone V in cadavers was 1 mm for flexor digitorum superficialis (FDS), flexor digitorum profundus (FDP) and flexor pollicis longus (FPL) tendons respectively. With simulated active flexion, the mean tendon excursion was 14 mm, 10 mm and 11 mm respectively. The mean tendon excursion in clinical cases intraoperatively following passive flexion was 2 mm for FDS, FDP and FPL respectively; following simulated active flexion it was 10 mm, 11 mm and 11 mm for FDS, FDP and FPL respectively. On the tenth day following repair, the mean excursions of FDS, FDP and FPL were 1 mm, 4 mm and 4 mm on passive flexion as compared to 3 mm, 10 mm and 12 mm on active flexion respectively. Three weeks postoperatively, the mean excursions of FDS, FDP and FPL tendons were 1 mm, 2 mm and 1 mm on passive flexion as compared to 5 mm, 15 mm on active flexion respectively. Six weeks postoperatively, the mean excursions of FDS, FDP and FPL tendons were 9 mm, 7 mm and 4 mm on passive flexion as compared to 12 mm, 33 mm and 20 mm on active flexion respectively. These results demonstrate an increased excursion of repaired flexor tendons in Zone V following an active flexion mobilisation regime as compared to a passive flexion mobilisation regime.

  20. Modulation of chest wall intermuscular coherence: effects of lung volume excursion and transcranial direct current stimulation.

    Science.gov (United States)

    Tomczak, Corey R; Greidanus, Krista R; Boliek, Carol A

    2013-08-01

    Chest wall muscle recruitment varies as a function of the breathing task performed. However, the cortical control of the chest wall muscles during different breathing tasks is not known. We studied chest wall intermuscular coherence during various task-related lung volume excursions in 10 healthy adults (34 ± 15 yr; 2 men, 8 women) and determined if transcranial direct current stimulation (tDCS) could modulate chest wall intermuscular coherence during these tasks. Simultaneous assessment of regional intercostal and oblique electromyographic activity was measured while participants performed standardized tidal breathing, speech, maximum phonation, and vital capacity tasks. Lung volume and chest wall kinematics were determined using variable inductance plethysmography. We found that chest wall area of intermuscular coherence was greater during tidal and speech breathing compared with phonation and vital capacity (all P < 0.05) and between tidal breathing compared with speech breathing (P < 0.05). Anodal tDCS increased chest wall area of intermuscular coherence from 0.04 ± 0.09 prestimulation to 0.18 ± 0.19 poststimulation for vital capacity (P < 0.05). Sham tDCS and cathodal tDCS had no effect on coherence during lung volume excursions. Chest wall kinematics were not affected by tDCS. Our findings indicate that lung volume excursions about the midrange of vital capacity elicit a greater area of chest wall intermuscular coherence compared with lung volume excursions spanning the entire range of vital capacity in healthy adults. Our findings also demonstrate that brief tDCS may modulate the cortical control of the chest wall muscles in a stimulation- and lung volume excursion task-dependent manner but does not affect chest wall kinematics in healthy adults.

  1. Into the deep: the functionality of mesopelagic excursions by an oceanic apex predator.

    Science.gov (United States)

    Howey, Lucy A; Tolentino, Emily R; Papastamatiou, Yannis P; Brooks, Edward J; Abercrombie, Debra L; Watanabe, Yuuki Y; Williams, Sean; Brooks, Annabelle; Chapman, Demian D; Jordan, Lance K B

    2016-08-01

    Comprehension of ecological processes in marine animals requires information regarding dynamic vertical habitat use. While many pelagic predators primarily associate with epipelagic waters, some species routinely dive beyond the deep scattering layer. Actuation for exploiting these aphotic habitats remains largely unknown. Recent telemetry data from oceanic whitetip sharks (Carcharhinus longimanus) in the Atlantic show a strong association with warm waters (>20°C) less than 200 m. Yet, individuals regularly exhibit excursions into the meso- and bathypelagic zone. In order to examine deep-diving behavior in oceanic whitetip sharks, we physically recovered 16 pop-up satellite archival tags and analyzed the high-resolution depth and temperature data. Diving behavior was evaluated in the context of plausible functional behavior hypotheses including interactive behaviors, energy conservation, thermoregulation, navigation, and foraging. Mesopelagic excursions (n = 610) occurred throughout the entire migratory circuit in all individuals, with no indication of site specificity. Six depth-versus-time descent and ascent profiles were identified. Descent profile shapes showed little association with examined environmental variables. Contrastingly, ascent profile shapes were related to environmental factors and appear to represent unique behavioral responses to abiotic conditions present at the dive apex. However, environmental conditions may not be the sole factors influencing ascents, as ascent mode may be linked to intentional behaviors. While dive functionality remains unconfirmed, our study suggests that mesopelagic excursions relate to active foraging behavior or navigation. Dive timing, prey constituents, and dive shape support foraging as the most viable hypothesis for mesopelagic excursions, indicating that the oceanic whitetip shark may regularly survey extreme environments (deep depths, low temperatures) as a foraging strategy. At the apex of these deep

  2. Beamlet focal plane diagnostic

    Energy Technology Data Exchange (ETDEWEB)

    Caird, J.A.; Nielsen, N.D.; Patton, H.G.; Seppala, L.G.; Thompson, C.E.; Wegner, P.J.

    1996-12-01

    This paper describes the major optical and mechanical design features of the Beamlet Focal Plane Diagnostic system as well as measurements of the system performance, and typical data obtained to date. We also discuss the NIF requirements on the focal spot that we are interested in measuring, and some of our plans for future work using this system.

  3. A study of systolic time intervals in lepra reaction.

    Science.gov (United States)

    Zawar, P B; Chawhan, R N; Mahajani, V V

    1983-10-01

    Systolic time intervals (STI) were measured in 20 control subjects and 20 cases of lepromatous leprosy in lepra reaction. Significant differences in the pre-ejection period (PEP), PEP/LVET and isovolumic contraction (IVCT) were observed between the groups. The abnormalities of STI observed in patients of lepra reaction are characteristic of left ventricular dysfunction in patients of lepra reaction.

  4. Automatic noninvasive measurement of systolic blood pressure using photoplethysmography

    Directory of Open Access Journals (Sweden)

    Glik Zehava

    2009-10-01

    Full Text Available Abstract Background Automatic measurement of arterial blood pressure is important, but the available commercial automatic blood pressure meters, mostly based on oscillometry, are of low accuracy. Methods In this study, we present a cuff-based technique for automatic measurement of systolic blood pressure, based on photoplethysmographic signals measured simultaneously in fingers of both hands. After inflating the pressure cuff to a level above systolic blood pressure in a relatively slow rate, it is slowly deflated. The cuff pressure for which the photoplethysmographic signal reappeared during the deflation of the pressure-cuff was taken as the systolic blood pressure. The algorithm for the detection of the photoplethysmographic signal involves: (1 determination of the time-segments in which the photoplethysmographic signal distal to the cuff is expected to appear, utilizing the photoplethysmographic signal in the free hand, and (2 discrimination between random fluctuations and photoplethysmographic pattern. The detected pulses in the time-segments were identified as photoplethysmographic pulses if they met two criteria, based on the pulse waveform and on the correlation between the signal in each segment and the signal in the two neighboring segments. Results Comparison of the photoplethysmographic-based automatic technique to sphygmomanometry, the reference standard, shows that the standard deviation of their differences was 3.7 mmHg. For subjects with systolic blood pressure above 130 mmHg the standard deviation was even lower, 2.9 mmHg. These values are much lower than the 8 mmHg value imposed by AAMI standard for automatic blood pressure meters. Conclusion The photoplethysmographic-based technique for automatic measurement of systolic blood pressure, and the algorithm which was presented in this study, seems to be accurate.

  5. Boundaries in digital planes

    Directory of Open Access Journals (Sweden)

    Efim Khalimsky

    1990-01-01

    Full Text Available The importance of topological connectedness properties in processing digital pictures is well known. A natural way to begin a theory for this is to give a definition of connectedness for subsets of a digital plane which allows one to prove a Jordan curve theorem. The generally accepted approach to this has been a non-topological Jordan curve theorem which requires two different definitions, 4-connectedness, and 8-connectedness, one for the curve and the other for its complement.

  6. BKP plane partitions

    Energy Technology Data Exchange (ETDEWEB)

    Foda, Omar; Wheeler, Michael [Department of Mathematics and Statistics, University of Melbourne, Parkville, Victoria 3010 (Australia)

    2007-01-15

    Using BKP neutral fermions, we derive a product expression for the generating function of volume-weighted plane partitions that satisfy two conditions. If we call a set of adjacent equal height-h columns, h > 0, an h-path, then 1. Every h-path can assume one of two possible colours. 2. There is a unique way to move along an h-path from any column to another.

  7. Measurement of tibial nerve excursion during ankle joint dorsiflexion in a weight-bearing position with ultrasound imaging

    Directory of Open Access Journals (Sweden)

    Carroll Matthew

    2012-03-01

    Full Text Available Abstract Background The ability of peripheral nerves to stretch and slide is thought to be of paramount importance to maintain ideal neural function. Excursion in peripheral nerves such as the tibial can be measured by analysis of ultrasound images. The aim of this study was to assess the degree of longitudinal tibial nerve excursion as the ankle moved from plantar flexion to dorsiflexion in a standardised weight-bearing position. The reliability of ultrasound imaging to measure tibial nerve excursion was also quantified. Methods The tibial nerve was imaged over two separate sessions in sixteen asymptomatic participants in a weight-bearing position. Longitudinal nerve excursion was calculated from a three-second video loop captured by ultrasound imaging using frame-by-frame cross-correlation analysis. Intraclass correlation coefficients (ICC with 95% confidence intervals (CI were used to assess the intra-rater reliability. Standard error of the measurement (SEM and smallest real difference (SRD were calculated to assess measurement error. Results Mean nerve excursion was 2.99 mm SEM ± 0.22 mm. The SRD was 0.84 mm for session 1 and 0.66 mm for session 2. Intra-rater reliability was excellent with an ICC = 0.93. Conclusions Assessment of real-time ultrasound images of the tibial nerve via frame-by-frame cross-correlation analysis is a reliable non-invasive technique to assess longitudinal nerve excursion. The relationship between foot posture and nerve excursion can be further investigated.

  8. [Cardiovascular risk stratification. Systolic, diastolic or pulse pressure?].

    Science.gov (United States)

    Pede, S; Lombardo, M

    2001-04-01

    It is well known that hypertension is a highly prevalent condition in the population, carries a significant risk of adverse cardiovascular events and is therapeutically difficult to control. These factors render it "a major unsolved - but soluble - mass public health problem". One of the present-day aspects of the complexity of managing patients with high blood pressure (BP) derives from clinical and epidemiological data that have emerged over the past 10 years: the growing importance of the clinical significance of systolic and pulse BP. The pathophysiological basis of these data is based, on the one hand, on a better articulated definition of the components of BP, and on the other, on precise information concerning age-related modifications. The common definition of BP does not take into account pressure fluctuations occurring during the cardiac cycle; in fact, systolic and diastolic BP denote the extreme values of continuous variations in differential pressure. Diastolic BP reflects, to a greater extent, the trend of arterial resistances and mean BP (usually calculated as diastolic BP plus one third of the differential BP, and considered the "stable component" of the arterial sphygmogram) and has long been used as a diagnostic and therapeutic target. Systolic BP is more closely linked to variations in pulse BP (given from the difference between systolic and diastolic BP and considered the "dynamic component" of the arterial sphygmogram) and is produced by a group of factors including left ventricular ejection and the reflection of the sphygmic wave. As age increases, the walls of the aorta and the large elastic arteries progressively harden due to senile degenerative phenomena and the loss of elasticity as well as the progressive diffusion of atherosdclerotic lesions. This leads to the reduced capacity of the arterial wall to distend during the systole with a consequent increase in both systolic and pulse BP. These pathophysiological data have important clinical

  9. On the reliability of frequency components in systolic arterial pressure in patients with atrial fibrillation.

    Science.gov (United States)

    Corino, Valentina D A; Lombardi, Federico; Mainardi, Luca T

    2010-04-01

    Atrial fibrillation (AF) is characterized by desynchronization of atrial electrical activity causing a consequent irregular ventricular response. In AF, the beat-to-beat variation of blood pressure is increased because of variations in filling time and contractility. However, only a few studies have analyzed short-term blood pressure variations in AF, and we have recently observed a harmonic low-frequency (LF) component in systolic arterial pressure (SAP) during AF. Aim of the present study is to propose a method to verify the reliability of the spectral component found in SAP series, based on the position of the poles of the autoregressive spectral decomposition in the z-plane. In particular, 1,000 random permutations of the series allowed the definition of an area in the z-plane where poles from random process are likely to occur. Poles lying outside this area are considered as reliable oscillations. We tested the method on 53 recordings obtained at rest from patients with persistent AF. LF component was found in, respectively, 51 and 43 recordings in SAP and RR series. High-frequency (HF) component was found in all the recordings for both SAP and RR series. Using the proposed test, the percentage of reliable components in LF and HF bands was 80 and 38 in SAP series, and 20 and 18 in RR series. We concluded that, at variance with RR ones, SAP LF components are likely to represent true physiological oscillations.

  10. Statistics of Dark Matter Halos in the Excursion Set Peak Framework

    CERN Document Server

    Lapi, A

    2014-01-01

    We derive approximated, yet very accurate analytical expressions for the abundance and clustering properties of dark matter halos in the excursion set peak framework; the latter relies on the standard excursion set approach, but also includes the effects of a realistic filtering of the density field, a mass-dependent threshold for collapse, and the prescription from peak theory that halos tend to form around density maxima. We find that our approximations work excellently for diverse power spectra, collapse thresholds and density filters. Moreover, when adopting a cold dark matter power spectra, a tophat filtering and a mass-dependent collapse threshold (supplemented with conceivable scatter), our approximated halo mass function and halo bias represent very well the outcomes of cosmological $N-$body simulations.

  11. Excursions and participation from companies in a weekly 5 ECTS course

    DEFF Research Database (Denmark)

    Ottosen, Lisbeth M.; Christensen, Iben Vernegren

    2011-01-01

    to civil engineering students (both at bachelor and master level) as an advanced and elective course. A maximum number of students in the course is set to 25 for practical reasons. Excursions to relevant sites with structures suffering from decay or where repair actions take place was one important...... on the connected topic than vice versa, probably because the ability to relate the theory to the real life made the topic seem more relevant to them. At the excursions the students took samples which they analysed in the laboratory at the university to enhance the active learning. As these samples are from real...... sites, they also reflect the huge variability at such sites and sometimes the results did not support the theory. The frustration of not knowing all upfront places the student in a situation well known to working engineers and formed background for relevant discussions. Experts from companies took part...

  12. Mono Lake Excursion as a Chronologic Marker in the U.S. Great Basin

    Science.gov (United States)

    Liddicoat, J. C.; Coe, R. S.; Knott, J. R.

    2008-05-01

    Nevada, Utah, and California east of the Sierra Nevada are in the Great Basin physiographic province of western North America. During periods of the Pleistocene, Lake Bonneville and Lake Lahontan covered valleys in Utah and Nevada, respectively, and other lakes such as Lake Russell in east-central California did likewise (Feth, 1964). Now dry except for its remnant, Mono Lake, Lake Russell provides an opportunity to study behavior of Earth's past magnetic field in lacustrine sediments that are exposed in natural outcrops. The sediments record at least 30,000 years of paleomagnetic secular variation (Liddicoat, 1976; Zimmerman et al., 2006) and have been of particular interest since the discovery of the Mono Lake Excursion (MLE) by Denham and Cox (1971) because the field behavior can be documented at numerous sites around Mono Lake (Liddicoat and Coe, 1979, Liddicoat, 1992; Coe and Liddicoat, 1994) and on Paoha Island in the lake. Moreover, there have been recent attempts to date the excursion (Kent et al., 2002, Benson et al., 2003) more accurately and use the age and relative field intensity in paleoclimate research (Zimmerman et al., 2006). It has been proposed that the excursion in the Mono Basin might be older than originally believed (Denham and Cox, 1971; Liddicoat and Coe, 1979) and instead be the Laschamp Excursion (LE), ~ 40,000 yrs B.P. (Guillou et al., 2004), on the basis of 14C and 40Ar/39Ar dates (Kent et al., 2002) and the relative paleointensity record (Zimmerman et al., 2006) for the excursion in the Mono Basin. On the contrary, we favor a younger age for the excursion, ~ 32,000 yrs B.P., using the relative paleointensity at the Mono and Lahontan basins and 14C dates from the Lahontan Basin (Benson et al., 2003). The age of ~ 32,000 yrs B.P. is in accord with the age (32,000-34,000 yrs B.P.) reported by Channell (2006) for the MLE at Ocean Drilling Program (ODP) Site 919 in the Irminger Basin in the North Atlantic Ocean, which contains as well an

  13. Correlation of Excursion Sets for Non-Gaussian CMB Temperature Distributions

    CERN Document Server

    Barreiro, R B; Martínez-González, E; Silk, J

    1997-01-01

    We present a method, based on the correlation function of excursion sets above a given threshold, to test the Gaussianity of the CMB temperature fluctuations in the sky. In particular, this method can be applied to discriminate between standard inflationary scenarios and those producing non-Gaussianity such as topological defects. We have obtained the normalized correlation of excursion sets, including different levels of noise, for 2-point probability density functions constructed from the Gaussian, \\chi_n^2 and Laplace 1-point probability density functions in two different ways. Considering subdegree angular scales, we find that this method can distinguish between different distributions even if the corresponding marginal probability density functions and/or the radiation power spectra are the same.

  14. Dark matter halo assembly bias: environmental dependence in the non-Markovian excursion set theory

    CERN Document Server

    Zhang, Jun; Riotto, Antonio

    2013-01-01

    In the standard excursion set model for the growth of structure, the statistical properties of haloes are governed by the halo mass and are independent of the larger scale environment in which the haloes reside. Numerical simulations, however, have found the spatial distributions of haloes to depend not only on their mass but also on the details of their assembly history and environment. Here we present a theoretical framework for incorporating this "assembly bias" into the excursion set model. Our derivations are based on modifications of the path integral approach of Maggiore & Riotto (2010) that models halo formation as a non-Markovian random walk process. The perturbed density field is assumed to evolve stochastically with the smoothing scale and exhibits correlated walks in the presence of a density barrier. We write down conditional probabilities for multiple barrier crossings, and derive from them analytic expressions for descendant and progenitor halo mass functions and halo merger rates as a func...

  15. Revealing the Microscopic Real-Space Excursion of a Laser-Driven Electron

    Directory of Open Access Journals (Sweden)

    Heiko G. Kurz

    2016-08-01

    Full Text Available High-order harmonic spectroscopy allows one to extract information on fundamental quantum processes, such as the exit time in the tunneling of an electron through a barrier with attosecond time resolution and molecular structure with angstrom spatial resolution. Here, we study the spatial motion of the electron during high-order harmonic generation in an in situ pump-probe measurement using high-density liquid water droplets as a target. We show that molecules adjacent to the emitting electron-ion pair can disrupt the electron’s trajectory when positioned within the range of the maximum electronic excursion distance. This allows us to use the parent ion and the neighboring molecules as boundaries for the electronic motion to measure the maximum electronic excursion distance during the high-order harmonic generation process. Our analysis of the process is relevant for optimizing high-harmonic yields in dense media.

  16. Cerium anomaly across the mid-Tournaisian carbon isotope excursion (TICE)

    Science.gov (United States)

    Jiang, G.; Morales, D. C.; Maharjan, D. K.

    2015-12-01

    The Early Mississippian (ca. 359-345 Ma) represents one of the most important greenhouse-icehouse climate transitions in Earth history. Closely associated with this critical transition is a prominent positive carbon isotope excursion (δ13C ≥ +5‰) that has been documented from numerous stratigraphic successions across the globe. This δ13C excursion, informally referred to as the TICE (mid-Tournaisian carbon isotope excursion) event, has been interpreted as resulting from enhanced organic carbon burial, with anticipated outcomes including the lowering of atmospheric CO2 and global cooling, the growth of continental ice sheets and sea-level fall, and the increase of ocean oxygenation and ocean redox changes. The casual relationship between these events has been addressed from various perspectives but not yet clearly demonstrated. To document the potential redox change associated with the perturbation of the carbon cycle, we have analyzed rare earth elements (REE) and trace elements across the TICE in two sections across a shallow-to-deep water transect in the southern Great Basin (Utah and Nevada), USA. In both sections, the REE data show a significant positive cerium (Ce) anomaly (Ce/Ce* = Ce/(0.5La+0.5Pr)). Prior to the positive δ13C shift, most Ce/Ce* values are around 0.3 (between 0.2 and 0.4). Across the δ13C peak, Ce/Ce* values increase up to 0.87, followed by a decrease back to 0.2~0.3 after the δ13C excursion (Figure 1). The positive Ce anomaly is best interpreted as recording expansion of oxygen minimum zone and anoxia resulted from increased primary production. This is consistent with a significant increase of nitrogen isotopes (δ15N) across the δ13C peak. Integration of the carbon, nitrogen, and REE data demonstrates a responsive earth systems change linked to the perturbation of the Early Mississippian carbon cycle.

  17. A Philatelic Excursion with Jeff Hunter in Probability and Matrix Theory

    Directory of Open Access Journals (Sweden)

    George P. H. Styan

    2007-01-01

    Full Text Available We present an excursion with Jeff Hunter, visiting some of his research topics. Specifically, we will present some facts about certain people whose work seems to have influenced Jeff in his scientific career; we illustrate our presentation with postage stamps that have been issued in honour of these people. Our main guide is Hunter’s two-volume book entitled Mathematical Techniques of Applied Probability (Academic Press, 1983.

  18. An investigation of the dynamic relationship between navicular drop and first metatarsophalangeal joint dorsal excursion.

    Science.gov (United States)

    Griffin, Nicole L; Miller, Charlotte; Schmitt, Daniel; D'Août, Kristiaan

    2013-06-01

    The modern human foot is a complex biomechanical structure that must act both as a shock absorber and as a propulsive strut during the stance phase of gait. Understanding the ways in which foot segments interact can illuminate the mechanics of foot function in healthy and pathological humans. It has been proposed that increased values of medial longitudinal arch deformation can limit metatarsophalangeal joint excursion via tension in the plantar aponeurosis. However, this model has not been tested directly in a dynamic setting. In this study, we tested the hypothesis that during the stance phase, subtalar pronation (stretching of the plantar aponeurosis and subsequent lowering of the medial longitudinal arch) will negatively affect the amount of first metatarsophalangeal joint excursion occurring at push-off. Vertical descent of the navicular (a proxy for subtalar pronation) and first metatarsophalangeal joint dorsal excursion were measured during steady locomotion over a flat substrate on a novel sample consisting of asymptomatic adult males and females, many of whom are habitually unshod. Least-squares regression analyses indicated that, contrary to the hypothesis, navicular drop did not explain a significant amount of variation in first metatarsophalangeal joint dorsal excursion. These results suggest that, in an asymptomatic subject, the plantar aponeurosis and the associated foot bones can function effectively within the normal range of subtalar pronation that takes place during walking gait. From a clinical standpoint, this study highlights the need for investigating the in vivo kinematic relationship between subtalar pronation and metatarsophalangeal joint dorsiflexion in symptomatic populations, and also the need to explore other factors that may affect the kinematics of asymptomatic feet.

  19. Boron and diagenesis: Questioning the fidelity of Snowball δ11B excursions

    Science.gov (United States)

    Foster, G. L.; Stewart, J.; Gutjahr, M.; Pearce, F.; Swart, P. K.

    2014-12-01

    Large negative carbon (δ13C) and boron (δ11B) isotope excursions (both >6‰) within the widely distributed Neoproterozoic "Snowball Earth" cap carbonates are interpreted as evidence for considerable perturbation of the carbon cycle and the associated reduction, then recovery of global ocean pH. Yet, before conclusive interpretations may be drawn, isotopic data must first be shown to be primary in origin and non-diagenetic. Recent studies of Quaternary carbonate platform sediments from a number of locations worldwide reveal δ13C excursions of similar magnitude and distribution to the "Snowball Earth" excursions. However, these recent analogues were formed following eustatic sea level fall and exposure of recent carbonates to meteoric diagenesis (Swart and Kennedy, 2012). Here we present δ11B and B/Ca data from Pleistocene-aged carbonate platform sediments recovered by the Clino Core from the Bahamas to examine the effects of diagenesis on the boron system. We find that within the interval of meteoric diagenesis the δ11B of bulk carbonate is substantially reduced by approximately 6‰ in conjunction with a drop in B/Ca of 90%. These isotopic and elemental down-core patterns are strikingly similar to those reported for δ11B and B/Ca in the cap carbonates of the Neoproterozoic snowball Earth events (Kasemann et al., 2005; Kasemann et al., 2010). Our results may therefore question the primary nature of "Snowball Earth" isotope excursions. We recommend more rigorous assessment of the diagenetic history of these ancient carbonates to ensure palaeoclimatological interpretations are robust.

  20. Analysis on blood glucose excursions in well-controlled patients with type 2 diabetes mellitus

    Institute of Scientific and Technical Information of China (English)

    Deng Wuquan; Yu Qiongwu; Wang Fuhua; Ai Zhihua; Chen Bing

    2009-01-01

    Objective: To probe glycemic excursions in type 2 diabetic patients whose hemoglobin A1c (HbA1c) was kept ≤6.0%.Methods: Totally 36 cases with type 2 diabetes (T2DM) with HbA1c≤6.0% and 30 cases with normal glucose tolerance (NGT) from December 2005 to December 2007 in our department were subjected prospectively. Continuous glucose monitoring system (CGMS) was employed to record their continuous blood glucose level for 3 d. The blood glucose profiles including the mean blood glucose (MBG), standard differentiation (SD), mean amplitude of glycemic excursions (MAGE) and absolute means of daily differences (MODD) were analyzed. Results: T2DM group had obviously postprandial hyperglycemia, in about 2 h after meal, especially after breakfast. Fifty-two hypoglycemic episodes occurred during the monitoring period in T2DM groups, of which 73.1% (38 episodes) were absence of symptomatic hypoglycemia with the lowest value of blood glucose only 2.0 mmol/L. And 20 episodes took place during the day hours, while 32 episodes observed during the night hours. Compared with NGT groups, SD, MAGE and MODD were all significantly higher in T2DM groups. MBG was significantly correlated with HbA1c in T2DM groups, but SD, MAGE, NGE and MODD were all independent of HbA1c. MAGE was independent of MODD. Conclusion: The amplitude of glycemic excursions is higher in normol-controlled T2DM groups than the NGT groups.Thus ideally glycemic control is not only to make HbA1c reach standard, but also to lessen glycemic excursions and reduce hypoglycemia episodes.

  1. Ocean sunfish rewarm at the surface after deep excursions to forage for siphonophores.

    Science.gov (United States)

    Nakamura, Itsumi; Goto, Yusuke; Sato, Katsufumi

    2015-05-01

    Ocean sunfish (Mola mola) were believed to be inactive jellyfish feeders because they are often observed lying motionless at the sea surface. Recent tracking studies revealed that they are actually deep divers, but there has been no evidence of foraging in deep water. Furthermore, the surfacing behaviour of ocean sunfish was thought to be related to behavioural thermoregulation, but there was no record of sunfish body temperature. Evidence of ocean sunfish feeding in deep water was obtained using a combination of an animal-borne accelerometer and camera with a light source. Siphonophores were the most abundant prey items captured by ocean sunfish and were typically located at a depth of 50-200 m where the water temperature was Ocean sunfish were diurnally active, made frequently deep excursions and foraged mainly at 100-200 m depths during the day. Ocean sunfish body temperatures were measured under natural conditions. The body temperatures decreased during deep excursions and recovered during subsequent surfacing periods. Heat-budget models indicated that the whole-body heat-transfer coefficient between sunfish and the surrounding water during warming was 3-7 times greater than that during cooling. These results suggest that the main function of surfacing is the recovery of body temperature, and the fish might be able to increase heat gain from the warm surface water by physiological regulation. The thermal environment of ocean sunfish foraging depths was lower than their thermal preference (c. 16-17 °C). The behavioural and physiological thermoregulation enables the fish to increase foraging time in deep, cold water. Feeding rate during deep excursions was not related to duration or depth of the deep excursions. Cycles of deep foraging and surface warming were explained by a foraging strategy, to maximize foraging time with maintaining body temperature by vertical temperature environment. © 2015 The Authors. Journal of Animal Ecology © 2015 British

  2. Conditional Probabilities in the Excursion Set Theory. Generic Barriers and non-Gaussian Initial Conditions

    CERN Document Server

    De Simone, Andrea; Riotto, Antonio

    2011-01-01

    The excursion set theory, where density perturbations evolve stochastically with the smoothing scale, provides a method for computing the dark matter halo mass function. The computation of the mass function is mapped into the so-called first-passage time problem in the presence of a moving barrier. The excursion set theory is also a powerful formalism to study other properties of dark matter halos such as halo bias, accretion rate, formation time, merging rate and the formation history of halos. This is achieved by computing conditional probabilities with non-trivial initial conditions, and the conditional two-barrier first-crossing rate. In this paper we use the recently-developed path integral formulation of the excursion set theory to calculate analytically these conditional probabilities in the presence of a generic moving barrier, including the one describing the ellipsoidal collapse, and for both Gaussian and non-Gaussian initial conditions. The non-Markovianity of the random walks induced by non-Gaussi...

  3. The Laschamp geomagnetic excursion featured in nitrate record from EPICA-Dome C ice core

    Science.gov (United States)

    Traversi, R.; Becagli, S.; Poluianov, S.; Severi, M.; Solanki, S. K.; Usoskin, I. G.; Udisti, R.

    2016-01-01

    Here we present the first direct comparison of cosmogenic 10Be and chemical species in the period of 38–45.5 kyr BP spanning the Laschamp geomagnetic excursion from the EPICA-Dome C ice core. A principal component analysis (PCA) allowed to group different components as a function of the main sources, transport and deposition processes affecting the atmospheric aerosol at Dome C. Moreover, a wavelet analysis highlighted the high coherence and in-phase relationship between 10Be and nitrate at this time. The evident preferential association of 10Be with nitrate rather than with other chemical species was ascribed to the presence of a distinct source, here labelled as “cosmogenic”. Both the PCA and wavelet analyses ruled out a significant role of calcium in driving the 10Be and nitrate relationship, which is particularly relevant for a plateau site such as Dome C, especially in the glacial period during which the Laschamp excursion took place. The evidence that the nitrate record from the EDC ice core is able to capture the Laschamp event hints toward the possibility of using this marker for studying galactic cosmic ray flux variations and thus also major geomagnetic field excursions at pluri-centennial-millennial time scales, thus opening up new perspectives in paleoclimatic studies. PMID:26819064

  4. Decreased diaphragm excursion in stroke patients with dysphagia as assessed by M-mode sonography.

    Science.gov (United States)

    Park, Geun-Young; Kim, Seong-Rim; Kim, Young Woo; Jo, Kwang Wook; Lee, Eu Jeen; Kim, Young Moon; Im, Sun

    2015-01-01

    To record diaphragm excursion via M-mode ultrasonography in stroke patients with dysphagia and determine whether they present reduced diaphragm excursion during voluntary cough compared with stroke patients without dysphagia and healthy subjects. Prospective cross-sectional study. University rehabilitation hospital. Acute stroke patients with dysphagia (n=23), acute stroke patients without dysphagia (n=24), and healthy control participants (n=27) (N=74). Not applicable. Diaphragm motions during quiet breathing, deep breathing, and voluntary coughing were recorded via ultrasonography using M-mode tracing (mm). Maximum inspiratory and expiratory pressures (cmH2O) and peak cough flow (L/min) during voluntary coughing were measured. The mean diaphragm movement (mm) of the hemiplegic side for all groups during quiet breathing, deep breathing, and voluntary coughing was 14.8±4.3, 17.6±4.8, and 20.9±3.7 (Pdysphagia explained up to 60% (Pdysphagia have decreased diaphragm excursion and compromised respiratory function during voluntary coughing. Copyright © 2015 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

  5. Review of the recording and age of the Mono Lake Excursion

    Science.gov (United States)

    Coe, R.; Liddicoat, J.

    2009-04-01

    Among the brief departures from gradual, long-term behaviour of the palaeomagnetic field in the Brunhes Normal Chron that reached opposite polarity or have a Virtual Geomagnetic Pole deep in the southern hemisphere, the first to be reported is the Laschamp Excursion (LE) in volcanic rocks in the Massif Central in France (Bonhommet and Zahringer, 1969). They originally believed it occurred between about 9,000 to 20,000 years before present, but it is now assigned an age of about 40,000 years B.P. (Guillou et al., 2004). Denham and Cox (1971) unsuccessfully sought the LE in exposed lake sediments that seemed to span that interval in the Mono Basin in the western Great Basin of the U.S., but instead encountered anomalous field behaviour that is called the Mono Lake Excursion (MLE)(Liddicoat and Coe, 1979). As a tribute to Norbert Bonhommet, who assisted us in our initial field work in the Mono Basin and shared a long-standing interest in the LE and MLE, we will review the palaeomagnetic behaviour and age of the MLE in the Mono Basin and elsewhere, for which there are nearly 20 reports of its occurrence globally, and evaluate the recent suggestion that the excursion at Mono Lake and the LE are the same.

  6. Plane and geodetic surveying

    CERN Document Server

    Johnson, Aylmer

    2004-01-01

    Plane and Geodetic Surveying blends theory and practice, conventional techniques and GPS, to provide the ideal book for students of surveying.Detailed guidance is given on how and when the principle surveying instruments (theodolites, Total Stations, levels and GPS) should be used. Concepts and formulae needed to convert instrument readings into useful results are explained. Rigorous explanations of the theoretical aspects of surveying are given, while at the same time a wealth of useful advice about conducting a survey in practice is provided. An accompanying least squares adjustment program

  7. Birth weight and systolic blood pressure in adolescence and adulthood

    DEFF Research Database (Denmark)

    Gamborg, Michael; Byberg, Liisa; Rasmussen, Finn

    2007-01-01

    The authors investigated the shape, sex- and age-dependency, and possible confounding of the association between birth weight and systolic blood pressure (SBP) in 197,954 adults from 20 Nordic cohorts (birth years 1910-1987), one of which included 166,249 Swedish male conscripts. Random-effects m......The authors investigated the shape, sex- and age-dependency, and possible confounding of the association between birth weight and systolic blood pressure (SBP) in 197,954 adults from 20 Nordic cohorts (birth years 1910-1987), one of which included 166,249 Swedish male conscripts. Random...... with a birth weight greater than 4 kg, SBP increased with birth weight (p groups (p

  8. Fluid responsiveness is predicted by analysis of extra systoles

    DEFF Research Database (Denmark)

    Vistisen, Simon Tilma

    INTRODUCTION. Fluid responsiveness prediction is an unsettled matter for intensive care patients. Preload variables are not reliable and ventilator settings for the vast majority of patients (if at all ventilated) do not accommodate the criteria for otherwise useful dynamic variables [1] (e.......g. pulse pressure variation). Yet, the idea of a varying preload utilised in dynamic variable monitoring may be useful: The extra systolic post-ectopic beat is associated with increased preload, and I hypothesised that systolic blood pressure (SBP) at the post-ectopic beat could be analysed in relation...... to surrounding sinus beats and that the magnitude of the SBP change (DSBP) could predict fluid responsiveness. OBJECTIVES. To study the hypothesis in post-cardiac surgery patients. METHODS. Patients scheduled for a 500 ml volume expansion were observed. In the time frame, 0-30 min prior to volume expansion, ECG...

  9. Left Ventricular Longitudinal Function Assessed by Speckle Tracking Ultrasound from a Single Apical Imaging Plane

    Directory of Open Access Journals (Sweden)

    Thomas Bagger

    2012-01-01

    Full Text Available Background. Transthoracic ultrasonography of the heart is valuable in monitoring and treatment of critically ill patients. Speckle tracking ultrasound (STU has proven valid in estimating left ventricular systolic deformation. The aims of the study were to compare conventional and automated STU and to determine whether left ventricular systolic deformation could be estimated from one single imaging plane. Methods. 2D-echocardiography cine-loops were obtained from 20 patients for off-line speckle tracking analysis, consisting of manually tracing of the endocardial border (conventional method or automatically drawn boundaries (automated method. Results. We found a bias of 0,6 (95% CI −2.2−3.3 for global peak systolic strain comparing the automated and the conventional method. Comparing global peak systolic strain of apical 4-chamber cine-loops with averaged Global Peak Strain obtained from apical 4, 2 and long axis cine-loops, showed a bias of 0.1 (95% CI −3.9−4.0. The agreement between subcostal 4-chamber and apical 4-chamber global peak systolic strain was 4.4 (95% CI −3.7−12.5. Conclusion. We found good agreement between the conventional and the automated method. STU applied to single apical 4-chamber cine-loops is in excellent agreement with overall averaged global peak systolic strain, while subcostal 4-chamber cine-loops proved less compliant with speckle tracking ultrasound.

  10. Fourier plane image amplifier

    Science.gov (United States)

    Hackel, L.A.; Hermann, M.R.; Dane, C.B.; Tiszauer, D.H.

    1995-12-12

    A solid state laser is frequency tripled to 0.3 {micro}m. A small portion of the laser is split off and generates a Stokes seed in a low power oscillator. The low power output passes through a mask with the appropriate hole pattern. Meanwhile, the bulk of the laser output is focused into a larger stimulated Brillouin scattering (SBS) amplifier. The low power beam is directed through the same cell in the opposite direction. The majority of the amplification takes place at the focus which is the fourier transform plane of the mask image. The small holes occupy large area at the focus and thus are preferentially amplified. The amplified output is now imaged onto the multichip module where the holes are drilled. Because of the fourier plane amplifier, only about 1/10th the power of a competitive system is needed. This concept allows less expensive masks to be used in the process and requires much less laser power. 1 fig.

  11. The Aerodynamic Plane Table

    Science.gov (United States)

    Zahm, A F

    1924-01-01

    This report gives the description and the use of a specially designed aerodynamic plane table. For the accurate and expeditious geometrical measurement of models in an aerodynamic laboratory, and for miscellaneous truing operations, there is frequent need for a specially equipped plan table. For example, one may have to measure truly to 0.001 inch the offsets of an airfoil at many parts of its surface. Or the offsets of a strut, airship hull, or other carefully formed figure may require exact calipering. Again, a complete airplane model may have to be adjusted for correct incidence at all parts of its surfaces or verified in those parts for conformance to specifications. Such work, if but occasional, may be done on a planing or milling machine; but if frequent, justifies the provision of a special table. For this reason it was found desirable in 1918 to make the table described in this report and to equip it with such gauges and measures as the work should require.

  12. The MOND Fundamental Plane

    CERN Document Server

    Cardone, V F; Diaferio, A; Tortora, C; Molinaro, R

    2010-01-01

    Modified Newtonian Dynamics (MOND) has been shown to be able to fit spiral galaxy rotation curves as well as giving a theoretical foundation for empirically determined scaling relations, such as the Tully - Fisher law, without the need for a dark matter halo. As a complementary analysis, one should investigate whether MOND can also reproduce the dynamics of early - type galaxies (ETGs) without dark matter. As a first step, we here show that MOND can indeed fit the observed central velocity dispersion $\\sigma_0$ of a large sample of ETGs assuming a simple MOND interpolating functions and constant anisotropy. We also show that, under some assumptions on the luminosity dependence of the Sersic n parameter and the stellar M/L ratio, MOND predicts a fundamental plane for ETGs : a log - linear relation among the effective radius $R_{eff}$, $\\sigma_0$ and the mean effective intensity $\\langle I_e \\rangle$. However, we predict a tilt between the observed and the MOND fundamental planes.

  13. Fourier plane image amplifier

    Science.gov (United States)

    Hackel, Lloyd A.; Hermann, Mark R.; Dane, C. Brent; Tiszauer, Detlev H.

    1995-01-01

    A solid state laser is frequency tripled to 0.3 .mu.m. A small portion of the laser is split off and generates a Stokes seed in a low power oscillator. The low power output passes through a mask with the appropriate hole pattern. Meanwhile, the bulk of the laser output is focused into a larger stimulated Brillouin scattering (SBS) amplifier. The low power beam is directed through the same cell in the opposite direction. The majority of the amplification takes place at the focus which is the fourier transform plane of the mask image. The small holes occupy large area at the focus and thus are preferentially amplified. The amplified output is now imaged onto the multichip module where the holes are drilled. Because of the fourier plane amplifier, only .about.1/10th the power of a competitive system is needed. This concept allows less expensive masks to be used in the process and requires much less laser power.

  14. Effects of Lead on Systolic and Diastolic Cardiac Functions

    Institute of Scientific and Technical Information of China (English)

    ZOUHE-JIAN; DINGYUE; 等

    1995-01-01

    In this paper,both systolic and diastolic cardiac functions were evaluated in 54 lead exposed and 24 non-exposed workers by Doppler echocardiography.With regard to systolic cardiac function,the results suggested that cardiac systolic function increased in exposed groups as a compensatory response for the effect of lead on myocardium.To study left ventricular diastolic function,2.5MHz pulsed Doppler analyses of transmitral flow velocity were performed from apical four-chamber view.The results showed that timerelated parameters were comparable among all groups,but blood flow velocity through the mitral valve and Doppler area fractions changed significantly in lead-exposed groups as evidenced by increased value A,decreased value E and E/A ratio.The decrease of diastolic cardiac function was more significant in lead intoxication group.It was also observed in this study that the activity in serum of the MB isoenzyme of creatine phosphokinase(CPK-MB),one of the indices of myocardial damage,was significantly higher in exposed group than that in control(P<0.05),and a positive correlation was found between CPK-MB activity and Pb-B.It denoted that the increasing of lead burden leads to more relase of CPK-MB from the myocardial cells and suggested the existence of slight myocardial damage,which conceivably,might cause harm to diastolic cardiac function.

  15. Contractility is the main determinant of coronary systolic flow impediment.

    Science.gov (United States)

    Krams, R; Sipkema, P; Zegers, J; Westerhof, N

    1989-12-01

    We measured the relation between coronary flow amplitude (delta F = Fd-Fs; where d is diastolic and s is systolic) and developed left ventricular pressure (delta PLV = Ps-Pd) at a constant perfusion pressure of 75 mmHg (10 kPa) in the maximally vasodilated blood-perfused isolated cat heart for different steady-state levels of contractility (protocol A) and during transients in contractility (protocol B). Contractility was defined as the slope of the end-systolic pressure-volume relation (Emax). From protocol A it appeared that the coronary flow amplitude was only weakly related to left ventricular pressure at each steady-state level of contractility studied. However, the coronary flow amplitude was strongly related to the different levels of contractility. In protocol B, contractility was changed over a wide range of values (0-100%) but developed pressure and contractility changed simultaneously. Using multiple linear regression analysis, we found that contractility has approximately 10 times (range: 2.8-57.3) stronger effect than left ventricular pressure on coronary flow amplitude (n = 10 experiments). These data and our earlier observations suggest that it is the difference in stiffness of cardiac muscle between systole and diastole that determines coronary flow amplitude.

  16. Decreasing systolic blood pressure with isometric muscle training: a CAT

    Directory of Open Access Journals (Sweden)

    Alexis Espinoza Salinas

    2014-09-01

    Full Text Available INTRODUCTION Hypertension is a major risk factor for cardiovascular diseases such as coronary heart disease or heart failure. One of the interventions for the management of this disorder is isometric muscle training on upper and lower limbs. PURPOSE To prove the validity and applicability of results regarding the effectiveness of isometric training in hypertensive subjects. We also attempt to answer the following question: what is the effectiveness of isometric muscle training on the decrease of systolic blood pressure in hypertensive patients? METHODS Critical appraisal of the systematic review and meta-analysis “Isometric exercise training for blood pressure management”. RESULTS Isometric training reduces systolic blood pressure in normotensive and medicated hypertensive subjects, with a standardized mean difference of 6.77 mm Hg (95% confidence interval: 7.93-5.62. CONCLUSION It is reasonable to recommend isometric muscle training with the aim of lowering systolic blood pressure, considering the impact of the results of the articles analyzed and the applicability of this type of training.

  17. Mono Lake Excursion in Cored Sediment from the Eastern Tyrrhenian Sea

    Science.gov (United States)

    Liddicoat, Joseph; Iorio, Marina; Sagnotti, Leonardo; Incoronato, Alberto

    2013-04-01

    A search for the Laschamp and Mono Lake excursions in cored marine and lacustrine sediment younger than 50,000 years resulted in the discovery of both excursions in the Greenland Sea (73.3˚ N, 351.0˚ E, Nowaczyk and Antanow, 1997), in the North Atlantic Ocean (62.7˚ N, 222.5˚ E, Channell, 2006), in Pyramid Lake in the Lahontan Basin, NV, USA (40.1˚ N, 240.2˚ E, Benson et al., 2008), and in the Black Sea (43.2˚ N, 36.5˚ E, Nowaczyk et al., 2012). The inclination, declination, and relative field intensity during the Mono Lake Excursion (MLE) in the Black Sea sediment matches well the behaviour of the excursion in the Mono Basin, CA, in that a reduction in inclination during westerly declination is soon followed by steep positive inclination when declination is easterly, and relative field intensity increases after a low at the commencement of the excursion (Liddicoat and Coe, 1979). A large clockwise loop of Virtual Geomagnetic Poles (VGPs) at the Black Sea when followed from old to young patterns very well the VGP loop formed by the older portion of the MLE in the Mono Basin (Liddicoat and Coe, 1979). We also searched for the MLE in cored sediment from the eastern Tyrrhenian Sea (40.1˚ N, 14.7˚ E) where the age of the sediment is believed to be about 32,000 years when comparing the susceptibility in the core with the susceptibility in a nearby one that is dated by palaeomagnetic secular variation records, Carbon-14, and numerous tephra layers in the Tyrrhenian Sea sediment (Iorio et al., 2011). In the Tyrrhenian Sea core, called C1067, closely spaced samples demagnetized in an alternating field to100 mT record a shallowing of positive inclination to 48˚ that is followed by steep positive inclination of 82˚ when declination moves rapidly to the southeast. The old to young path of the VGPs in C1067 forms a narrow counter-clockwise loop that reaches 30.3˚ N, 30.8˚ E and that is centered at about 55˚ N, 15˚ E. Although descending to a latitude that is

  18. Stress area of the mandibular alveolar mucosa under complete denture with linear occlusion at lateral excursion

    Institute of Scientific and Technical Information of China (English)

    LU Ya-lin; LOU Hang-di; RONG Qi-guo; DONG Jian; XU Jun

    2010-01-01

    Background The rocking and instability of a loaded complete denture (CD) during lateral excursion reduce the bearing area under the denture base, causing localized high stress concentrations. This can lead to mucosal tenderness, ulceration, and alveolar bone resorption, and the linear occlusion design was to decrease the lateral force exerted on the denture and to ensure denture stability. But it is not known how the bearing areas of linear occlusal CDs (LOCDs) and anatomic occlusal CDs (AOCDs) differ. The purpose of this study was to analyze and compare the distributions of the high and low vertical stress-bearing areas in the mandibular alveolar mucosa under LOCDs and AOCDs at lateral excursion.Methods Computerized tomography (CT) and finite element analysis were used to establish three-dimensional models of an edentulous maxilla and mandible with severe residual ridge resorption. These models were composed of maxillary and mandibular bone structure, mucosa, and the LOCD or AOCD. Lateral excursion movements of the mandible were simulated and the vertical stress-bearing areas in the mucosa under both mandibular CDs were analyzed using ANSYS 7.0.Results On the working side, the high stress-bearing (-0.07 to -0.1 Mpa) area under the LOCD during lateral excursion was smaller than that under the AOCD, while the medium stress-bearing (-0.03 to -0.07 Mpa) area under the LOCD was 1.33-fold that under the AOCD. The medium stress-bearing area on the non-working side under the LOCD was 2.4-fold that under the AOCD. Therefore, the overall medium vertical stress-bearing area under the LOCD was 20% larger than that under the AOCD.Conclusions During lateral excursion, the medium vertical stress-bearing area under a mandibular LOCD was larger and the high vertical stress-bearing area was smaller than that under an AOCD. Thus, the vertical stress under the LOCD was distributed more evenly and over a wider area than that under the AOCD, thereby improving denture stability.

  19. Local times and excursion theory for Brownian motion a tale of Wiener and Itô measures

    CERN Document Server

    Yen, Ju-Yi

    2013-01-01

    This monograph discusses the existence and regularity properties of local times associated to a continuous semimartingale, as well as excursion theory for Brownian paths. Realizations of Brownian excursion processes may be translated in terms of the realizations of a Wiener process under certain conditions. With this aim in mind, the monograph presents applications to topics which are not usually treated with the same tools, e.g.: arc sine law, laws of functionals of Brownian motion, and the Feynman-Kac formula.

  20. Plane symmetric cosmological models

    CERN Document Server

    Yadav, Anil Kumar; Ray, Saibal; Mallick, A

    2016-01-01

    In this work, we perform the Lie symmetry analysis on the Einstein-Maxwell field equations in plane symmetric spacetime. Here Lie point symmetries and optimal system of one dimensional subalgebras are determined. The similarity reductions and exact solutions are obtained in connection to the evolution of universe. The present study deals with the electromagnetic energy of inhomogeneous universe where $F_{12}$ is the non-vanishing component of electromagnetic field tensor. To get a deterministic solution, it is assumed that the free gravitational field is Petrov type-II non-degenerate. The electromagnetic field tensor $F_{12}$ is found to be positive and increasing function of time. As a special case, to validate the solution set, we discuss some physical and geometric properties of a specific sub-model.

  1. Duality and noncommutative planes

    DEFF Research Database (Denmark)

    Jøndrup, Søren

    2015-01-01

    We study extensions of simple modules over an associative ring A   and we prove that for twosided ideals mm and nn with artinian factors the condition ExtA1(A/m,A/n)≠0 holds for the left A  -modules A/mA/m and A/nA/n if and only if it holds for the right modules A/nA/n and A/mA/m. The methods pro...... proving this are applied to show that noncommutative models of the plane, i.e. algebras of the form k〈x,y〉/(f)k〈x,y〉/(f), where f∈([x,y])f∈([x,y]) are noetherian only in case (f)=([x,y])...

  2. Atrial Fibrillation Ablation in Systolic Dysfunction: Clinical and Echocardiographic Outcomes

    Directory of Open Access Journals (Sweden)

    Tasso Julio Lobo

    2015-01-01

    Full Text Available Background: Heart failure and atrial fibrillation (AF often coexist in a deleterious cycle. Objective: To evaluate the clinical and echocardiographic outcomes of patients with ventricular systolic dysfunction and AF treated with radiofrequency (RF ablation. Methods: Patients with ventricular systolic dysfunction [ejection fraction (EF <50%] and AF refractory to drug therapy underwent stepwise RF ablation in the same session with pulmonary vein isolation, ablation of AF nests and of residual atrial tachycardia, named "background tachycardia". Clinical (NYHA functional class and echocardiographic (EF, left atrial diameter data were compared (McNemar test and t test before and after ablation. Results: 31 patients (6 women, 25 men, aged 37 to 77 years (mean, 59.8±10.6, underwent RF ablation. The etiology was mainly idiopathic (19 p, 61%. During a mean follow-up of 20.3±17 months, 24 patients (77% were in sinus rhythm, 11 (35% being on amiodarone. Eight patients (26% underwent more than one procedure (6 underwent 2 procedures, and 2 underwent 3 procedures. Significant NYHA functional class improvement was observed (pre-ablation: 2.23±0.56; postablation: 1.13±0.35; p<0.0001. The echocardiographic outcome also showed significant ventricular function improvement (EF pre: 44.68%±6.02%, post: 59%±13.2%, p=0.0005 and a significant left atrial diameter reduction (pre: 46.61±7.3 mm; post: 43.59±6.6 mm; p=0.026. No major complications occurred. Conclusion: Our findings suggest that AF ablation in patients with ventricular systolic dysfunction is a safe and highly effective procedure. Arrhythmia control has a great impact on ventricular function recovery and functional class improvement.

  3. Iron deficiency in chronic systolic heart failure(indic study

    Directory of Open Access Journals (Sweden)

    Sunil Verma

    2016-01-01

    Full Text Available Background: Chronic systolic heart failure (HF is characterized by the left ventricular dysfunction, exercise intolerance and is associated with neurohormonal activation that affects several organs such as kidney and skeletal muscle. Anemia is common in HF and may worsen symptoms. Iron deficiency (ID is also common in HF patients with or without anemia. Iron is the key cofactor in oxidative metabolism in skeletal muscle and the Krebs cycle. There is a paucity of data regarding iron metabolism in chronic systolic HF in India. Methods: IroN Deficiency In CHF study (INDIC is an observational study that investigated forty chronic heart failure patients for the presence of ID. Serum ferritin (micrograms per liter, serum iron (micrograms per liter, total iron binding capacity (micrograms per liter, transferring (milligrams per deciliter, and transferrin saturation were measured to assess iron status. Results: There were 67.5% (27/40 patients who had ID with a mean serum ferritin level of 76.4 μg/L. Of the 27 iron deficient patients, 22 (55% had an absolute ID, and 5 had a functional ID. Eight out of 27 of the iron deficient patients were anemic (20% of the total cohort, 30% of the iron deficient patients. Anemia was seen in 6 other patients, which was possibly anemia of chronic disease. There was a trend for more advanced New York Heart Association (NYHA class (NYHA III and NYHA IV patients with ID (37.4% vs. 30.77%, P = 0.697. Conclusion: In our study, ID was very common, affecting more than half of the patients with systolic HF. Absolute ID was the most common cause of ID and patients with ID had a tendency to have advanced NYHA class. Our study also demonstrated that ID can occur in the absence of anemia (iron depletion.

  4. Systoles of 2-complexes, Reeb graph, and Grushko decomposition

    OpenAIRE

    Katz, Mikhail G.; Rudyak, Yuli B.; Sabourau, Stephane

    2006-01-01

    Let X be a finite 2-complex with unfree fundamental group. We prove lower bounds for the area of a metric on X, in terms of the square of the least length of a noncontractible loop in X. We thus establish a uniform systolic inequality for all unfree 2-complexes. Our inequality improves the constant in M. Gromov's inequality in this dimension. The argument relies on the Reeb graph and the coarea formula, combined with an induction on the number of freely indecomposable factors in Grushko's dec...

  5. Euglycemic clamp insulin sensitivity and longitudinal systolic blood pressure

    DEFF Research Database (Denmark)

    Petrie, John R; Malik, Muhammad Omar; Balkau, Beverley

    2013-01-01

    Insulin resistance may be an independent risk factor for the development of hypertension, but change in blood pressure (BP) over time has not been adequately studied in healthy individuals fully characterized for insulin sensitivity. In the Relationship between Insulin Sensitivity...... and Cardiovascular disease (RISC) study, we measured insulin sensitivity (M/I) using the euglycemic clamp technique in 1073 healthy European adults (587 women, 486 men) aged 30 to 60 years followed up 3 years later. Systolic BP (SBP) at baseline was higher in insulin-resistant women (ie, those in the low sex...

  6. Epaxial muscle fiber architecture favors enhanced excursion and power in the leaper Galago senegalensis.

    Science.gov (United States)

    Huq, Emranul; Wall, Christine E; Taylor, Andrea B

    2015-10-01

    Galago senegalensis is a habitual arboreal leaper that engages in rapid spinal extension during push-off. Large muscle excursions and high contraction velocities are important components of leaping, and experimental studies indicate that during leaping by G. senegalensis, peak power is facilitated by elastic storage of energy. To date, however, little is known about the functional relationship between epaxial muscle fiber architecture and locomotion in leaping primates. Here, fiber architecture of select epaxial muscles is compared between G. senegalensis (n = 4) and the slow arboreal quadruped, Nycticebus coucang (n = 4). The hypothesis is tested that G. senegalensis exhibits architectural features of the epaxial muscles that facilitate rapid and powerful spinal extension during the take-off phase of leaping. As predicted, G. senegalensis epaxial muscles have relatively longer, less pinnate fibers and higher ratios of tendon length-to-fiber length, indicating the capacity for generating relatively larger muscle excursions, higher whole-muscle contraction velocities, and a greater capacity for elastic energy storage. Thus, the relatively longer fibers and higher tendon length-to-fiber length ratios can be functionally linked to leaping performance in G. senegalensis. It is further predicted that G. senegalensis epaxial muscles have relatively smaller physiological cross-sectional areas (PCSAs) as a consequence of an architectural trade-off between fiber length (excursion) and PCSA (force). Contrary to this prediction, there are no species differences in relative PCSAs, but the smaller-bodied G. senegalensis trends towards relatively larger epaxial muscle mass. These findings suggest that relative increase in muscle mass in G. senegalensis is largely attributable to longer fibers. The relative increase in erector spinae muscle mass may facilitate sagittal flexibility during leaping. The similarity between species in relative PCSAs provides empirical support for

  7. Development of the System to Support Tourists’ Excursion Behavior using Augmented Reality

    Directory of Open Access Journals (Sweden)

    Jiawen ZHOU

    2016-07-01

    Full Text Available The purpose of this study is to develop an information system (AR recommended GIS to support tourists’ excursion behavior by making the accumulating, sharing, and recommending of information concerning urban tourist spots possible. The conclusion of this study can be summarized into three points as shown below. (1 In order to support tourists’ excursion behaviors by integrating SNS, Twitter, Web-GIS, recommendation system, and Smart Eyeglass, in addition to making the accumulating, sharing, and recommending of information regarding urban tourist spots possible, the AR recommended GIS was designed and developed. (2 91% were between the age of 20-40 among the 91 users, and the ultimate number of submitted information was 161. In addition, concerning the operation using Smart Eyeglass, which was conducted with tourists in the Minato Mirai area, the total number of users were 34, age of users were spread out, and all users had no experience in using Smart Eyeglasses. (3 From the results of the Web questionnaire survey, the system is compatible for the collection method of tourist spot information for users, and is mainly used to collect tourist spot information using the viewing and recommendation functions. From the results of the access analysis using the log data form during the operation, the utilization method of the system with PCs and mobile information terminals were very similar. Additionally, as the system using AR Smart Eyeglass was rated extremely highly, it was evident that it is possible to support tourists’ excursion behavior using PCs, mobile information terminals, and AR Smart Eyeglasses are possible.

  8. Paleomagnetic Excursion Recorded in Exposed Lacustrine Sediments on Paoha Island in Mono Lake, CA.

    Science.gov (United States)

    Liddicoat, J. C.; Coe, R. S.

    2016-12-01

    Paleomagnetic secular variation (PSV) in the Wilson Creek Formation that was deposited in Pleistocene Lake Russell in the Mono Basin, CA, has been known for nearly 50 years. The research began in the late 1960s during a search for the Laschamp Excursion (LE) believed then to have occurred between about 20,000 and 9,000 years ago (Bonhommet and Zahringer, 1969). Although that investigation was unsuccessful in locating the LE in the eroded bank of Wilson Creek on the northwest side of Mono Lake, which is the remnant of Lake Russell, anomalous field behavior was documented that is the Mono Lake Excursion (MLE)(Denham and Cox, 1971; Liddicoat and Coe, 1979). We did a PSV investigation of a portion of the Wilson Creek Formation where it is exposed on Paoha Island in the center of Mono Lake. Using volcanic ash layers from the nearby Mono Craters as stratigraphc marker beds and the tephrochronology of Lajoie (1993), we located anomalous field behavior that is similar to the field behavior during the MLE with some exceptions. One is the onset of negative inclination 45 cm beneath a 7-cm rhyolitic ash bed. That position is four times lower in the formation than negative inclination beneath Ash 15 that is midway in the MLE at three localities in the basin - Wilson Creek, Mill Creek, and Warm Springs (Liddicoat, 1992). Declination, inclination, and relative field intensity (RFI) where we sampled on Paoha Island are different enough from the paleomagnetic field behavior during the MLE that the possibility exists that a second excursion is recorded in the Wilson Creek Formation. We will present the paleomagnetic directions and RFI that are recorded on Paoha Island for that field behavior.

  9. Excursion guide for the 6th IMCG field symposium in Norway 1994

    OpenAIRE

    1994-01-01

    This guide contains a description of the variations found among the mires in central Norway. The main emphasis is on the hydromorphology, flora and vegetation, but the bird fauna and conservational aspects are also included. The regionality of the vegetation is stressed (5 zones/belts and 5 sections have been mapped). Nine main mire localities that will be visited during the excursion are also described. Rørmyra (locality l), Kaldvassmyra (2) and Toppmyr/Røkmyr (9) are southern boreal mires w...

  10. Power semiconductors empirical diagrams expressing life as a function of temperature excursion

    Energy Technology Data Exchange (ETDEWEB)

    Somos, I.L. (Somos Electra, Lansdowne, PA (United States)); Piccone, D.E.; Willinger, L.J.; Tobin, W.H. (General Electric Co., Malvern, PA (United States))

    1993-01-01

    Solid state switches are being actively pursued to replace thyratons, ignitrons and triggered spark gaps in various pulse power applications. These include electric gun development for tanks such as the EM gun (electromagnetic) and the ETC gun (electrothermal) and electromechanical launcher for aircraft. High power thyristors and rectifier diodes have been applied in stringent power cycling applications in the past with predictable life assurance. The validity of a simple mathematical concept expression life in terms of numbers of power cycles versus temperature excursion is explained and supported by examples of empirical tests data.

  11. Excursion sets of infinitely divisible random fields with convolution equivalent Lévy measure

    DEFF Research Database (Denmark)

    Rønn-Nielsen, Anders; Jensen, Eva B. Vedel

    We consider a continuous, infinitely divisible random field in R d , d = 1, 2, 3, given as an integral of a kernel function with respect to a Lévy basis with convolution equivalent Lévy measure. For a large class of such random fields we compute the asymptotic probability that the excursion set a...... at level x contains some rotation of an object with fixed radius as x → ∞. Our main result is that the asymptotic probability is equivalent to the right tail of the underlying Lévy measure...

  12. Benchmarking of flowtran with Mark-22 mockup flow excursion test data from Babcock & Wilcox

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Juo-Fu

    1990-06-01

    Version 16.2 of the FLOWTRAN code with a Savannah River Site (SRS) working criterion (St=0.00455) for the onset of significant void (OSV) was benchmarked against power and flow excursion data derived from tests at the Babcock & Wilcox Alliance Research Center test facility. This document presents analyses which show that FLOWTRAN accurately predicts the mockup test assembly thermal-hydraulic behavior during the steady state and LOCA transient conditions, and that FLOWTRAN with a Savannah River Site (SRS) working limits criterion (St=0.00455) conservatively predicts the OFI power.

  13. Benchmarking of flowtran with Mark-22 mockup flow excursion test data from Babcock Wilcox

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Juo-Fu.

    1990-06-01

    Version 16.2 of the FLOWTRAN code with a Savannah River Site (SRS) working criterion (St=0.00455) for the onset of significant void (OSV) was benchmarked against power and flow excursion data derived from tests at the Babcock Wilcox Alliance Research Center test facility. This document presents analyses which show that FLOWTRAN accurately predicts the mockup test assembly thermal-hydraulic behavior during the steady state and LOCA transient conditions, and that FLOWTRAN with a Savannah River Site (SRS) working limits criterion (St=0.00455) conservatively predicts the OFI power.

  14. Systolic blood pressure, arterial rigidity, and risk of stroke. The Framingham study.

    Science.gov (United States)

    Kannel, W B; Wolf, P A; McGee, D L; Dawber, T R; McNamara, P; Castelli, W P

    1981-03-27

    Based on prospective data from the Framingham study relating systolic pressure, diastolic pressure, age, and pulse-wave configuration to future stroke incidence, it would appear that isolated systolic hypertension predisposes to stroke independent of arterial rigidity. The prevalence of isolated systolic hypertension increased with age and with the degree of blunting of the dicrotic notch in the pulse wave. Subjects with isolated systolic hypertension experienced two to four times as many strokes as did normotensive persons. While diastolic pressure is related to stroke incidence, in the subject with systolic hypertension, the diastolic component adds little to risk assessment and in men, in this subgroup, appears unrelated to stroke incidence.

  15. Elevated systolic pressure following chronic low-level cadmiun feeding.

    Science.gov (United States)

    Perry, H M; Erlanger, M; Perry, E F

    1977-02-01

    Groups of 16 female Long-Evans rats received 0, 1, 2.5, 5, 10, 25, and 50 mg cadmium/liter dringking water (parts per million (ppm)), from the time they were weaned until they were 30 mo old. Systolic pressure was measured indirectly in triplicate at 6-mo intervals. Both 2.5 and 5 ppm cadmium consistently induced significant elevations in mean systolic pressure, ranging from 13 to 33 mmHg. At 6 mo, 10 and 25 ppm cadmium also induced significant elevations, whereas at 12 mo and subsequently 1 ppm cadmium induced significant elevations. With 10 ppm cadmium or less weight gain was normal and there was no evidence of cadmium toxicity. With 25 and 50 ppm cadmium weight gain was diminished, suggesting toxicity. Five rats with each level of exposure were sacrificed every 6 mo from a second population of similarly handled rats in order to determine renal cadmium concetrations. Cadmium intakes that had induced hypertension were associated with mean renal cadmium concentrations ranging from 5 to 50 mug/g kidney.

  16. Some linear-time algorithms for systolic arrays

    CERN Document Server

    Brent, Richard P; Kung, H T

    2010-01-01

    We survey some results on linear-time algorithms for systolic arrays. In particular, we show how the greatest common divisor (GCD) of two polynomials of degree n over a finite field can be computed in time O(n) on a linear systolic array of O(n) cells; similarly for the GCD of two n-bit binary numbers. We show how n * n Toeplitz systems of linear equations can be solved in time O(n) on a linear array of O(n) cells, each of which has constant memory size (independent of n). Finally, we outline how a two-dimensional square array of O(n)* O(n) cells can be used to solve (to working accuracy) the eigenvalue problem for a symmetric real n* n matrix in time O(nS(n)). Here S(n) is a slowly growing function of n; for practical purposes S(n) can be regarded as a constant. In addition to their theoretical interest, these results have potential applications in the areas of error-correcting codes, symbolic and algebraic computations, signal processing and image processing.

  17. Invasively Measured Aortic Systolic Blood Pressure and Office Systolic Blood Pressure in Cardiovascular Risk Assessment: A Prospective Cohort Study

    DEFF Research Database (Denmark)

    Laugesen, Esben; Knudsen, Søren T; Hansen, Klavs W

    2016-01-01

    myocardial infarction, stroke, and death. Discrimination and reclassification were assessed using Harrell's C and the Continuous Net Reclassification Index. Data were analyzed with and without stratification by diabetes mellitus status. During a median follow-up period of 3.7 years (range: 0.1-10.8 years......), 422 strokes, 511 myocardial infarctions, and 1530 deaths occurred. Both office and aortic systolic BP were associated with stroke in patients with diabetes mellitus (hazard ratio per 10 mm Hg, 1.18 [95% confidence interval, 1.07-1.30] and 1.14 [95% confidence interval, 1.05-1.24], respectively...

  18. Plane Mercury librations

    Science.gov (United States)

    Barkin, Yu. V.; Ferrandiz, J. M.

    2009-04-01

    theory of Mercury librations in longitude by using three characteristics of Mercury rotation determined in the paper [3]. Two from these parameters are values of angle of librations in longitude and angular velocity in moment of passage of perihelion of Mercury orbit on 17 April 2002: (^g)0 = 0007 ± 0001, (^?•? )0 = (2.10± 0.06)•? ars/d. Third parameter determined in [3] is a dynamical coefficient: K = (B -A)•(4Cm ) = (5.08± 0.30) × 10-5. B > A are principal moment of inertia, corresponding to equatorial axes of inertia; Cm is a polar moment of inertia of the mantle of Mercury. 1 Analytical theory of plane Mercury librations. This theory describes forced and free librations of Mercury in longitude in the frame of plane problem about resonant librations of Mercury considered or as non-spherical rigid body, or as system of rigid non-spherical mantle and liquid ellipsoidal core. Saving the main terms for the perturbations of angle of librations ^g and angular velocity ^? in both mentioned cases we will have formulae [6]: ^g = K(E sin M + E sin2M + E sin 3M + E sin4M + E sin5M ) 1 2 3 4 5+K0 sin(E šKM- - φ) (A)

  19. Effects of diaphragm stretching on posterior chain muscle kinematics and rib cage and abdominal excursion: a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Francisco J. González-Álvarez

    2016-01-01

    Full Text Available ABSTRACT Background Few studies have explored the effects of stretching techniques on diaphragm and spine kinematics. Objective To determine whether the application of diaphragm stretching resulted in changes in posterior chain muscle kinematics and ribcage and abdominal excursion in healthy subjects. Method Eighty healthy adults were included in this randomized clinical trial. Participants were randomized into two groups: the experimental group, which received a diaphragmatic stretching technique, or the placebo group, which received a sham-ultrasound procedure. The duration of the technique, the position of participants, and the therapist who applied the technique were the same for both treatments. Participant assessment (cervical range of movement, lumbar flexibility, flexibility of the posterior chain, and rib cage and abdominal excursion was performed at baseline and immediately after the intervention by a blinded assessor. Results The mean between-group difference [95% CI] for the ribcage excursion after technique at xiphoid level was 2.48 [0.97 to 3.99], which shows significant differences in this outcome. The remaining between-group analysis showed significant differences in cervical extension, right and left flexion, flexibility of the posterior chain, and ribcage excursion at xiphoid level (p<0.05 in favor of the experimental group. Conclusion Diaphragm stretching generates a significant improvement in cervical extension, right and left cervical flexion, flexibility of the posterior chain, and ribcage excursion at xiphoid level compared to a placebo technique in healthy adults.

  20. A New 62-sample Record of the Mono Lake Excursion Waveform from the Depocenter Sediments of Summer Lake, OR

    Science.gov (United States)

    Negrini, R. M.; McCuan, D. T.; Horton, R. A.; Verosub, K. L.

    2011-12-01

    A new core from Summer Lake, Oregon provides the primary datset for a composite, 62-sample record of the Mono Lake Excursion (MLE) waveform. The magnetograms and virtual geomagnetic poles (VGPs) are consistent with those associated with the MLE record from Mono Lake (e.g., Liddicoat and Coe, 1979). The added detail from this new record firmly establishes three distinct VGP clusters centered first on easternmost Asia/Siberia, then on Europe, and, finally, on North America. The jumps between clusters involve typically one sample, which represents only a few decades of time. The excursion is bracketed by tephra of known age (the Mount St. Helens Cy 46.0 ± 6 ka and the Wono 27.3 ± 0.3 14C kyr B.P.) and the age of the excursion is ~28 14C kyr B.P based on an average of five radiocarbon ages from below, within and above the excursion interval. A second waveform that exhibits shallowing inclinations and easterly declination swings upsection is truncated by a prominent unconformity. These PSV features and the associated RPI leading up to this unconformity correlate with those of the onset of the Laschamp Excursion (Lund et al., 2005). Both radiocarbon and PSV correlations support missing sediment from the Summer Lake record between 42.5 and 38 GISP2 ka. This sediment hiatus correlates to unconformities or lowstands in other Great Basin lakes suggesting a Heinrich 4-induced drought that affected much of western North America.

  1. Gravitational Couplings for Gop-Planes and y-Op-Planes

    CERN Document Server

    Ospina-Giraldo, J F

    2000-01-01

    The Wess-Zumino actions for generalized orientifold planes (GOp-planes) and y-deformed orientifold planes (yOp-planes) are presented and two series power expantions are realized from whiches processes that involves GOp-planes,yOp-planes, RR-forms, gravitons and gaugeons, are obtained. Finally non-standard GOp-planes and y-Op-planes are showed.

  2. Variations in Star Excursion Balance Test Performance Between High School and Collegiate Football Players.

    Science.gov (United States)

    McCann, Ryan S; Kosik, Kyle B; Beard, Megan Q; Terada, Masafumi; Pietrosimone, Brian G; Gribble, Phillip A

    2015-10-01

    The Star Excursion Balance Test (SEBT) is a reliable inexpensive tool used to assess dynamic postural control deficits and efficacy in the prediction of musculoskeletal injuries, but with little previous consideration for performance differences across age and skill levels. The purpose of this study was to examine differences in SEBT scores between high school and collegiate football players. Three-hundred eighteen high school football players and 180 National Collegiate Athletic Association Division I collegiate football players volunteered to participate. Star Excursion Balance Test scores were obtained bilaterally for anterior (ANT), posterolateral (PL), and posteromedial (PM) directions, and for an overall composite (COMP) score. The mean of 3 trials from each leg was normalized to stance leg length and presented as a percentage score. Bilaterally averaged scores were compared between high school and collegiate football players using separate independent t-tests. A multiple linear backward regression determined the amount of variance in SEBT scores explained by age, mass, and height. Compared with collegiate athletes, high school athletes had lower PL (72.8 ± 11.4% vs. 77.1 ± 10.2%; p football players.

  3. Mary Poppins and the Soviet Pilgrimage: P.L.Travers's Moscow Excursion (1934

    Directory of Open Access Journals (Sweden)

    John McNair

    2013-02-01

    Full Text Available Like the journey it chronicles, Moscow Excursion, P.L.Travers’s account of her 1932 visit to Russia, was in part inspired by the genre it effectively parodies: the ‘Soviet pilgrimage’ ‘truth about Russia’ narrative characteristic of the Stalin decades and exemplified (in the Australian context by Katharine Susannah Prichard’s The Real Russia, also published in 1934. The paper examines the ways in which Travers’s book is written against this genre to produce an avowedly ‘un-political’ record whose narrator rejects the restrictions of organized travel, and whose idiosyncratic and critical observations on Soviet reality contrast with the admiration of her more orthodox fellow-travellers for the usual showcase institutions on the official itinerary. At the same time, it is argued that in its blend of self-deprecating irony, whimsy and disillusioned idealism Moscow Excursion suggests parallels with Travers’s personal quest for ‘the truth’ and even with Mary Poppins, published only two months later.

  4. Lower Triassic Inorganic Carbon Isotope Excursion in Chaohu, Anhui Province, China

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    This paper reports a Lower Triassic inorganic carbon isotope profile from the North Ping-dingshan Section in Chaohu, Anhui Province, China, which was situated in a deep part of the LowerYangtze carbonate ramp. The δ(13C) excursion shows two periods from the Permian-Triassic boundaryto the lower Spathian substage, corresponding to the ecosystem undergoing evolution and recovery afterthe end-Permian mass extinction and related events. The first period starts at the δ (13 C) depletioncaused by the mass extinction and evolves with a gradual δ(13C) increase resulting from the developmentof some disaster taxa during the Induan. The strong Smithian δ(13 C) depletion in the second periodmight be formed by the collapse of the disaster ecosystem and the biotic recovery occurred with the explo-sive increase of bioproductivity in the Spathian. Thus the δ(13C) excursion in the Lower Triassic expres-ses patterns of biotic evolution and recovery during the erratic ecosystem that followed the great end-Permian mass extinction.

  5. Possible record of the Laschamp Excursion in lacustrine sediments in the Searles Valley, California

    Science.gov (United States)

    Liddicoat, J.; Coe, R.; Knott, J.

    2009-04-01

    The Pleistocene history of Searles Lake, California, is known in detail from field work and cores recovered during industrial exploration of Searles Valley, in which the lake formed (Smith et al., 1979; Liddicoat et al., 1980). Exposed siltstone assigned the age about 34,000 to 46,000 calendar years B.P. (eight AMS 14-Carbon dates on gastropods and mollusks from fine- to medium-grain sand units that bracket the siltstone) records reverse palaeomagnetic polarity following thermal demagnetization to 600˚ C at two localities 3 km apart. For 12 samples (six pairs from six horizons, three pairs from each locality), the mean palaeomagnetic directions are Incl = - 37.5˚, Decl = 180.2˚, alpha 95 = 19.5˚ and the mean Virtual Geomagnetic Pole (VGP) is 73.6˚ S, 231.8˚ E, Alpha 95 = 20.6˚. The reverse polarity is not part of the Mono Lake Excursion (Denham and Cox, 1971) that never has a VGP in the Southern Hemisphere (Liddicoat and Coe, 1979). Other samples from the two Searles Valley localities do not reach a definite reverse direction but contain a component of magnetization that approaches reverse polarity above 400˚ C. The reverse polarity in Searles Lake sediments offers an opportunity to model the geomagnetic field for two excursions (Laschamp and Mono Lake) in western North America at localities separated by about 300 km.

  6. Potential for water-table excursions induced by seismic events at Yucca Mountain, Nevada

    Science.gov (United States)

    Carrigan, Charles R.; King, Geoffrey C. P.; Barr, George E.; Bixler, Nathan E.

    1991-12-01

    The possibility that 100-200 m changes in water-table elevation can be mechanically induced by earthquakes is a consideration in site studies of a potential high-level nuclear waste repository at Yucca Mountain, Nevada. However, numerical simulations of tectonohydrologic coupling involving earthquakes typical of the Basin and Range province produce 2-3 m excursions of a water table that is 500 m below the land surface. Even displacements corresponding to extraordinary seismic events drive water-table excursions of less than 20 m. Flow resulting from earthquake-induced pore-pressure fields below the water table tends to be mainly horizontal; vertical flows that cause changes of the level of the water table are secondary. Strongly anisotropic permeability, intended to enhance vertical flow within fault zones, only doubles water-table rise in the models considered. These simulations of water-table rise compare well with observations following large earthquakes in the Basin and Range. Our models suggest that exceptional hydrologic and/or tectonic conditions would be required to produce substantially larger water-table rises.

  7. Possible recording of the Mono Lake Excursion in cored sediment from Clear Lake, California

    Science.gov (United States)

    Liddicoat, Joseph; Verosub, Kenneth

    2010-05-01

    We report the possible recording of the Mono Lake Excursion (MLE) in cored sediment from Clear Lake, CA. The locality (39.0˚N, 237.3˚E) is about 120 km north of San Francisco, CA, and 320 km northwest of the Mono Basin, CA, where the MLE first was discovered in North America (Denham and Cox, 1971). The field behaviour at Clear Lake that might be the MLE is recorded in clay and peaty clay about 50 cm below the top of the lowermost 80-cm core slug of a 21.6-m core. The coring was done by the wire-line method (Sims and Rymer, 1975) and the samples (rectangular solids 21 mm on a side and 15 mm high) were measured in a cryogenic magnetometer after demagnetization in an alternating field to 35 milliTesla (Verosub, 1977). The continuously-spaced samples record negative inclination of nearly 20˚ and northerly declination when unnormalized relative field intensity was reduced by an order of magnitude from the mean value. Those palaeomagnetic directions are followed immediately by positive inclination to about 50˚ and easterly declination of about 60˚ when the field intensity is at a relative high. That pattern of behaviour is recorded at three localities (Wilson Creek, Mill Creek, and Warm Springs) in the Mono Basin at the MLE (Liddicoat and Coe, 1979; Liddicoat, 1992). A path of the Virtual Geomagnetic Poles (VGPs) at Clear Lake form a clockwise-trending loop that is centered at 65˚N, 20˚E in the hemisphere away from the locality. The VGP that is farthest from the North Geographic Pole is at 29.3˚N, 337.1˚E, which is close to the path formed by the VGPs in the older portion of the MLE (Liddicoat and Coe, 1979; Liddicoat, 1992). The age of the sediment recording the anomalous palaeomagnetic directions in Clear Lake is about 30,000 years B.P. (Verosub, 1977). That age was determined from six (uncalibrated) radiocarbon dates, three of which are from near the base of the core (Sims and Rymer, 1975) where there are the anomalous palaeomagnetic directions, and linear

  8. Evolutes of Hyperbolic Plane Curves

    Institute of Scientific and Technical Information of China (English)

    Shyuichi IZUMIYA; Dong He PEI; Takashi SANO; Erika TORII

    2004-01-01

    We define the notion of evolutes of curves in a hyperbolic plane and establish the relationships between singularities of these subjects and geometric invariants of curves under the action of the Lorentz group. We also describe how we can draw the picture of an evolute of a hyperbolic plane curve in the Poincar(e) disk.

  9. Conceptual Design of Wave Plane

    DEFF Research Database (Denmark)

    Frigaard, Peter; Trewers, Andrew; Kofoed, Jens Peter;

    The Wave Plane is a patented Wave Energy device of the overtopping type, designed to capture potential as well as kinetic energy. This is as such different to other overtopping devices, who usually only focus on potential energy. If Wave Plane A/S can deliver the turbine technology to utilize both...

  10. Target blood pressure for treatment of isolated systolic hypertension in the elderly: valsartan in elderly isolated systolic hypertension study.

    Science.gov (United States)

    Ogihara, Toshio; Saruta, Takao; Rakugi, Hiromi; Matsuoka, Hiroaki; Shimamoto, Kazuaki; Shimada, Kazuyuki; Imai, Yutaka; Kikuchi, Kenjiro; Ito, Sadayoshi; Eto, Tanenao; Kimura, Genjiro; Imaizumi, Tsutomu; Takishita, Shuichi; Ueshima, Hirotsugu

    2010-08-01

    In this prospective, randomized, open-label, blinded end point study, we aimed to establish whether strict blood pressure control (blood pressure control (> or =140 mm Hg to hypertension. We divided 3260 patients aged 70 to 84 years with isolated systolic hypertension (sitting blood pressure 160 to 199 mm Hg) into 2 groups, according to strict or moderate blood pressure treatment. A composite of cardiovascular events was evaluated for > or =2 years. The strict control (1545 patients) and moderate control (1534 patients) groups were well matched (mean age: 76.1 years; mean blood pressure: 169.5/81.5 mm Hg). Median follow-up was 3.07 years. At 3 years, blood pressure reached 136.6/74.8 mm Hg and 142.0/76.5 mm Hg, respectively. The blood pressure difference between the 2 groups was 5.4/1.7 mm Hg. The overall rate of the primary composite end point was 10.6 per 1000 patient-years in the strict control group and 12.0 per 1000 patient-years in the moderate control group (hazard ratio: 0.89; [95% CI: 0.60 to 1.34]; P=0.38). In summary, blood pressure targets of or = 70 years of age with isolated systolic hypertension, although our trial was underpowered to definitively determine whether strict control was superior to less stringent blood pressure targets.

  11. Middle-Upper Ordovician (Darriwilian-Early Katian) Positive Carbon Isotope Excursions in the Northern Tarim Basin, Northwest China:Implications for Stratigraphic Correlation and Paleoclimate

    Institute of Scientific and Technical Information of China (English)

    Cunge Liu; Guorong Li; Dawei Wang; Yongli Liu; Mingxia Luo; Xiaoming Shao

    2016-01-01

    ABSTRACT:Three positive carbon isotope excursions are reported from Middle–Upper Ordovician in Tahe oil-gas field, northern Tarim Basin. Based on conodont biostratigraphy, the Middle Darriwilian Isotope Carbon Excursion (MDICE) and the Guttenberg Carbon Isotope Excursion (GICE) are identified from Darriwilian to Early Katian by the aid of whole-rock carbon isotope data from two well cores. Positive excursion within conodont Pygodus anserinus zone is developed in Early Sandbian, and the fluctuation range is no less than MDICE. Because the range of this excursion in the generalized global carbon isotope curve is short, previous studies paid little attention to it, and named Early Sandbian Isotope Carbon Excursion (ESICE) in this paper. Furthermore, these positive excursions are not directly related to sea level fluctuations and the MDICE and GICE identified in northern Tarim can be globally correlated to that in southern China, North America, South America, and Europe. The Saergan Fm. source rocks of Middle-Upper Ordovician in Kalpin Dawangou outcrop are in accord with the geologic time of MDICE and ESICE, and GICE have strong ties to the source rock of Lianglitag Fm. in basin. Abundant organic carbon burial is an important factor in genesis of positive isotope carbon excursions. Positive oxygen isotope excursion, conodont fauna turnover, decreased conodont total diversity, and the change of sedimentary facies indicated that dramatic changes of paleoceanographic environment of Early-Middle Ordovician in Tarim Basin started from the end of Darriwillian, and an obvious icehouse climate of Late Ordovician occurred in ESICE.

  12. Protein kinase C epsilon induces systolic cardiac failure marked by exhausted inotropic reserve and intact Frank-Starling mechanism.

    Science.gov (United States)

    Montgomery, David E; Rundell, Veronica L M; Goldspink, Paul H; Urboniene, Dalia; Geenen, David L; de Tombe, Pieter P; Buttrick, Peter M

    2005-11-01

    Myofilament dysfunction is a common point of convergence for many forms of heart failure. Recently, we showed that cardiac overexpression of PKC epsilon initially depresses myofilament activity and then leads to a progression of changes characteristic of human heart failure. Here, we examined the effects of PKC epsilon on contractile reserve, Starling mechanism, and myofilament activation in this model of end-stage dilated cardiomyopathy. Pressure-volume loop analysis and echocardiography showed that the PKC epsilon mice have markedly compromised systolic function and increased end-diastolic volumes. Dobutamine challenge resulted in a small increase in contractility in PKC epsilon mice but failed to enhance cardiac output. The PKC epsilon mice showed a normal length-dependent tension development in skinned cardiac muscle preparations, although Frank-Starling mechanism appeared to be compromised in the intact animal. Simultaneous measurement of tension and ATPase demonstrated that the maximum tension and ATPase were markedly lower in the PKC epsilon mice at any length or Ca2+ concentration. However, the tension cost was also lower indicating less energy expenditure. We conclude 1) that prolonged overexpression of PKC epsilon ultimately leads to a dilated cardiomyopathy marked by exhausted contractile reserve, 2) that PKC epsilon does not compromise the Frank-Starling mechanism at the myofilament level, and 3) that the Starling curve excursion is limited by the inotropic state of the heart. These results reflect the significance of the primary myofilament contractilopathy induced by phosphorylation and imply a role for PKC epsilon-mediated phosphorylation in myofilament physiology and the pathophysiology of decompensated cardiac failure.

  13. Assessment of right ventricular systolic function by tissue Doppler echocardiography

    DEFF Research Database (Denmark)

    Kjærgaard, Jesper

    2012-01-01

    is a promising tool for improving our understanding of right ventricular hemodynamics, several aspects of the technology must be evaluated. The accuracy and reproducibility of the technology is evaluated in vitro, and normal values, impact of changes in loading of the right ventricle, response to exercise...... gained from other quantitative echocardiographic measures of LV and RV function and pressure [VI]. Changes in tissue Doppler based measures of RV systolic function can be used to monitor the effect of selective vasodilation by phosphodiestares-5 inhibition in hypoxic pulmonary hypertension and exercise...... in normal individuals. Phosphodiestares-5 inhibition by sildenafil may predominantly be effective during hypoxia in resting conditions, and may improve the blunted response in RV contractility seen with exercise in hypoxia [VII]. Reduced RV free wall deformation can be quantified by tissue Doppler...

  14. Floating-point systolic array including serial processors

    Energy Technology Data Exchange (ETDEWEB)

    Leeland, S.B.

    1989-10-03

    This patent describes, in a systolic array system utilizing a plurality of semiconductor chips, a semiconductor chip. It comprises: a plurality of processing elements each including a floating-point serial processor and a plurality of data storage registers; global bus means coupled to the serial processor of each of the plurality of processing elements for inputing and outputing data to and from each chip and for programming each serial processor; and a plurality of data buses coupled to each of the plurality of data storage registers of each of the plurality of processing elements. The global bus means being coupled to the plurality of data storage registers for programming the data storage registers.

  15. Systolic time intervals after a seven-day orbital flight

    Science.gov (United States)

    Groza, P.; Vrâncianu, R.; Lazǎr, M.; Baevski, R. M.; Funtova, V. L.

    Heart rate, systolic time intervals (pre-ejection period, left ventricular ejection time), ejection fraction, stroke volume and QT interval of two cosmonauts (Leonid Popov - L.P. and Dumitru Prunariu - D.P.) were studied before, during, and after an ergometric bicycle exercise test performed before and after the seven-day Soviet-Romanian orbital flight on the Soyuz 40 - Salyut 6 Complex in May 1981. For this purpose one precordial electrocardiogram (ecg) and the ear photodensitogram (den) were recorded stimulaneously. The method used permitted recording even during exercise, Ecg and den signals were stored on magnetic tape, processed in an analogue device and in a digital computer. The data obtained after landing suggest a slight cardiac deconditioning in L.P., demonstrated especially by augmentation of the pre-ejection period, which was unchanged in D.P. corresponding to a sympathoadrenergic hypertonia. The seven-day orbital flight has not produced important cardiovascular changes.

  16. Detrended Fluctuation Analysis of Systolic Blood Pressure Control Loop

    CERN Document Server

    Galhardo, C E C; de Menezes, M Argollo; Soares, P P S

    2009-01-01

    We use detrended fluctuation analysis (DFA) to study the dynamics of blood pressure oscillations and its feedback control in rats by analyzing systolic pressure time series before and after a surgical procedure that interrupts its control loop. We found, for each situation, a crossover between two scaling regions characterized by exponents that reflect the nature of the feedback control and its range of operation. In addition, we found evidences of adaptation in the dynamics of blood pressure regulation a few days after surgical disruption of its main feedback circuit. Based on the paradigm of antagonistic, bipartite (vagal and sympathetic) action of the central nerve system, we propose a simple model for pressure homeostasis as the balance between two nonlinear opposing forces, successfully reproducing the crossover observed in the DFA of actual pressure signals.

  17. Assessment of right ventricular systolic function by tissue Doppler echocardiography

    DEFF Research Database (Denmark)

    Kjærgaard, Jesper

    2012-01-01

    myocardial velocities, but no changes in SR, strain or isovolumic acceleration could be observed [II and III]. Tissue Doppler echocardiography of the RV free wall in non-massive pulmonary embolism quantifies degree of RV dysfunction, and supports the existence of the McConnell sign of mid-ventricular RV...... structure including significant dilatation, but is well tolerated with only mild reduction in measures of global RV systolic function as estimated by 2D echocardiography in an experimental animal model. Regional RV myocardial function is also only mildly reduced. Also no differences in global or regional RV......This thesis summarizes a series of studies performed in order to assess the clinical usefulness of a novel echocardiographic technology that allows non-invasive assessment of regional right ventricular myocardial velocities and deformation: tissue Doppler echocardiography. While the technology...

  18. Women, Hypertension, and the Systolic Blood Pressure Intervention Trial.

    Science.gov (United States)

    Wenger, Nanette K; Ferdinand, Keith C; Bairey Merz, C Noel; Walsh, Mary Norine; Gulati, Martha; Pepine, Carl J

    2016-10-01

    Hypertension accounts for approximately 1 in 5 deaths in American women and is the major contributor to many comorbid conditions. Although blood pressure lowering reduces cardiovascular disease outcomes, considerable uncertainty remains on best management in women. Specifically, female blood pressure treatment goals have not been established, particularly among older and African American and Hispanic women, for whom hypertension prevalence, related adverse outcomes, and poor control rates are high. The Systolic Blood Pressure Intervention Trial (SPRINT) planned to clarify optimal blood pressure management in both sexes. Although confirming that a lower blood pressure goal is generally better, because female enrollment and event rates were low and follow-up shortened, outcomes differences in women were not statistically significant. Thus optimal blood pressure goals for women have not been established with the highest evidence. This review addresses SPRINT's significance and key remaining knowledge gaps in optimal blood pressure management to improve women's health.

  19. Glucose excursions and glycaemic control during Ramadan fasting in diabetic patients: insights from continuous glucose monitoring (CGM).

    Science.gov (United States)

    Lessan, N; Hannoun, Z; Hasan, H; Barakat, M T

    2015-02-01

    Ramadan fasting represents a major shift in meal timing and content for practicing Muslims. This study used continuous glucose monitoring (CGM) to assess changes in markers of glycaemic excursions during Ramadan fasting to investigate the short-term safety of this practice in different groups of patients with diabetes. A total of 63 subjects (56 with diabetes, seven healthy volunteers; 39 male, 24 female) had CGM performed during, before and after Ramadan fasting. Mean CGM curves were constructed for each group for these periods that were then used to calculate indicators of glucose control and excursions. Post hoc data analyses included comparisons of different medication categories (metformin/no medication, gliptin, sulphonylurea and insulin). Medication changes during Ramadan followed American Diabetes Association guidelines. Among patients with diabetes, there was a significant difference in mean CGM curve during Ramadan, with a slow fall during fasting hours followed by a rapid rise in glucose level after the sunset meal (iftar). The magnitude of this excursion was greatest in the insulin-treated group, followed by the sulphonylurea-treated group. Markers of control deteriorated in a small number (n=3) of patients. Overall, whether fasting or non-fasting, subjects showed no statistically significant changes in mean interstitial glucose (IG), mean amplitude of glycaemic excursion (MAGE), high and low blood glucose indices (HBGI/LBGI), and number of glucose excursions and rate of hypoglycaemia. The main change in glycaemic control with Ramadan fasting in patients with diabetes is in the pattern of excursions. Ramadan fasting caused neither overall deterioration nor improvement in the majority of patients with good baseline glucose control. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  20. A comparison between brachial and echocardiographic systolic time intervals.

    Directory of Open Access Journals (Sweden)

    Ho-Ming Su

    Full Text Available Systolic time interval (STI is an established noninvasive technique for the assessment of cardiac function. Brachial STIs can be automatically determined by an ankle-brachial index (ABI-form device. The aims of this study are to evaluate whether the STIs measured from ABI-form device can represent those measured from echocardiography and to compare the diagnostic values of brachial and echocardiographic STIs in the prediction of left ventricular ejection fraction (LVEF <50%. A total of 849 patients were included in the study. Brachial pre-ejection period (bPEP and brachial ejection time (bET were measured using an ABI-form device and pre-ejection period (PEP and ejection time (ET were measured from echocardiography. Agreement was assessed by correlation coefficient and Bland-Altman plot. Brachial STIs had a significant correlation with echocardiographic STIs (r = 0.644, P<0.001 for bPEP and PEP; r  = 0.850, P<0.001 for bET and ET; r = 0.708, P<0.001 for bPEP/bET and PEP/ET. The disagreement between brachial and echocardiographic STIs (brachial STIs minus echocardiographic STIs was 28.55 ms for bPEP and PEP, -4.15 ms for bET and ET and -0.11 for bPEP/bET and PEP/ET. The areas under the curve for bPEP/bET and PEP/ET in the prediction of LVEF <50% were 0.771 and 0.765, respectively. Brachial STIs were good alternatives to STIs obtained from echocardiography and also helpful in prediction of LVEF <50%. Brachial STIs automatically obtained from an ABI-form device may be helpful for evaluation of left ventricular systolic dysfunction.

  1. Systolic blood pressure and (cardiac) mortality over 15 years after venous coronary bypass surgery.

    Science.gov (United States)

    Voors, A A; van Brussel, B L; Kelder, J C; Plokker, H W

    1997-10-01

    The aim of the present study was to determine the influence of pre-operative systolic blood pressure and systolic blood pressure 1 and 5 years after venous coronary bypass surgery on subsequent cardiac and non-cardiac mortality. A prospective 15 years follow-up study. A series of 446 consecutive coronary bypass surgery patients, operated on between April 1976 and April 1977. According to their systolic blood pressure, patients were divided into five groups. Systolic blood pressure 5 years after surgery, but not pre-operative systolic blood pressure, was an independent predictor of cardiac mortality. Multivariate Cox proportional hazards analysis revealed that pre-operative systolic blood pressure was not associated with cardiac mortality, while higher systolic blood pressure 1 year after surgery showed a trend towards increased cardiac mortality. Systolic blood pressure 5 years after surgery appeared to be a strong independent predictor of cardiac mortality during the subsequent follow-up period. Patients with a systolic blood pressure of 130-139 mmHg had the lowest risk. Compared to this group, the cardiac mortality risk in patients with a systolic blood pressure 5 years after surgery of 140-149 mmHg, 150-159 mmHg and > or = 160 mmHg, was 2.3 (1.2 to 4.6), 3.4 (1.6 to 7.1) and 3.1 (1.4 to 6.5) times higher. Systolic blood pressure < 130 mmHg 5 years after surgery was also associated with a 2.3 times (1.1 to 4.7) times increased risk for cardiac mortality, compared to patients with a systolic blood pressure of 130-139 mmHg. These findings underline the importance of systolic blood pressure control in the initial years after coronary bypass surgery.

  2. New mitral annular force transducer optimized to distinguish annular segments and multi-plane forces.

    Science.gov (United States)

    Skov, Søren Nielsen; Røpcke, Diana Mathilde; Ilkjær, Christine; Rasmussen, Jonas; Tjørnild, Marcell Juan; Jimenez, Jorge H; Yoganathan, Ajit P; Nygaard, Hans; Nielsen, Sten Lyager; Jensen, Morten Olgaard

    2016-03-21

    Limited knowledge exists about the forces acting on mitral valve annuloplasty repair devices. The aim of this study was to develop a new mitral annular force transducer to measure the forces acting on clinically used mitral valve annuloplasty devices. The design of an X-shaped transducer in the present study was optimized for simultaneous in- and out-of-plane force measurements. Each arm was mounted with strain gauges on four circumferential elements to measure out-of-plane forces, and the central parts of the X-arms were mounted with two strain gauges to measure in-plane forces. A dedicated calibration setup was developed to calibrate isolated forces with tension and compression for in- and out-of-plane measurements. With this setup, it was possible with linear equations to isolate and distinguish measured forces between the two planes and minimize transducer arm crosstalk. An in-vitro test was performed to verify the crosstalk elimination method and the assumptions behind it. The force transducer was implanted and evaluated in an 80kg porcine in-vivo model. Following crosstalk elimination, in-plane systolic force accumulation was found to be in average 4.0±0.1N and the out-of-plane annular segments experienced an average force of 1.4±0.4N. Directions of the systolic out-of-plane forces indicated movements towards a saddle shaped annulus, and the transducer was able to measure independent directional forces in individual annular segments. Further measurements with the new transducer coupled with clinical annuloplasty rings will provide a detailed insight into the biomechanical dynamics of these devices.

  3. Ca and Mg isotope constraints on the origin of Earth's deepest δ13 C excursion

    Science.gov (United States)

    Husson, Jon M.; Higgins, John A.; Maloof, Adam C.; Schoene, Blair

    2015-07-01

    Understanding the extreme carbon isotope excursions found in carbonate rocks of the Ediacaran Period (635-541 Ma), where δ13 C of marine carbonates (δ13 Ccarb) reach their minimum (- 12 ‰) for Earth history, is one of the most vexing problems in Precambrian geology. Known colloquially as the 'Shuram' excursion, the event has been interpreted by many as a product of a profoundly different Ediacaran carbon cycle. More recently, diagenetic processes have been invoked, with the very negative δ13 C values of Ediacaran carbonates explained via meteoric alteration, late-stage burial diagenesis or growth of authigenic carbonates in the sediment column, thus challenging models which rely upon a dramatically changing redox state of the Ediacaran oceans. Here we present 257 δ 44 / 40 Ca and 131 δ26 Mg measurements, along with [Mg], [Mn] and [Sr] data, from carbonates of the Ediacaran-aged Wonoka Formation (Fm.) of South Australia to bring new isotope systems to bear on understanding the 'Shuram' excursion. Data from four measured sections spanning the basin reveal stratigraphically coherent trends, with variability of ∼1.5‰ in δ26 Mg and ∼1.2‰ in δ 44 / 40 Ca. This Ca isotope variability dwarfs the 0.2-0.3 ‰ change seen coeval with the Permian-Triassic mass extinction, the largest recorded in the rock record, and is on par with putative changes in the δ 44 / 40 Ca value of seawater seen over the Phanerozoic Eon. Changes in both isotopic systems are too large to explain with changes in the isotopic composition of Ca and Mg in global seawater given modern budgets and residence times, and thus must be products of alternative processes. Relationships between δ 44 / 40 Ca and [Sr] and δ26 Mg and [Mg] are consistent with mineralogical control (e.g., aragonite vs. calcite, limestone vs. dolostone) on calcium and magnesium isotope variability. The most pristine samples in the Wonoka dataset, preserving Sr concentrations (in the 1000s of ppm range) and δ 44 / 40

  4. Paleointensities of the Auckland Excursion from Volcanic Rocks in New Zealand

    Science.gov (United States)

    Mochizuki, N.; Tsunakawa, H.; Shibuya, H.; Cassidy, J.; Smith, I. E.

    2001-12-01

    Shibuya et al. (1992) reported the Auckland excursion from several basaltic lava flows of monogenetic volcanic centers (forced to introduce correction for thermal alterations in laboratory heating, using low temperature part of the Arai plot. We, therefore, applied the double heating technique (DHT) of Shaw method (Tsunakawa and Shaw, 1994), which was capable of detecting inappropriate results by the ARM correction, to the samples. The low temperature demagnetization (LTD) was combined with DHT (Yamamoto et al., submitted) before AF demagnetization and samples were heated in a vacuum of 10-100 Pa. Sixty-one samples from the five lava flows were subjected to the LTD-DHT Shaw method. Twenty-three of these samples yielded successful results passing the selection criteria. Five out of six paleointensities from the Crater Hill lava were consistent with each other. A mean paleointensity was given to be 10.9+/- 1.9 μ T (N=5) for the Crater Hill lava. Five out of seven paleointensities from the Wiri lava, were consistent and a mean was 10.8+/- 1.2 μ T (N=5). Three samples from the Puketutu lava gave a mean paleointensity of 11.4+/- 0.8 μ T (N=3). These three lava flows, Crater Hill, Wiri and Puketutu lava, all recorded the north-down paleodirection and gave almost the same paleointensities of ~ 11 μ T. This concordance of paleointensities and paleodirections supports the reliability of the paleointensity determination. Four paleointensities were obtained from the Hampton Park lava of the west paleodirection, and gave a mean paleointensity of 10.1+/- 1.1 μ T (N=4). The field strength was comparable to that of the north-down group. Three samples from the McLennan Hills lava of the south paleodirection gave quite low paleointensities, a mean of which was calculated to be 2.4+/- 0.6 μ T (N=3). These five paleointensities from the Auckland excursion are no more than one-fifth of the present-field intensity. The corresponding VDMs range from 0.6x1022 to 2.3*E22Am2, which

  5. Possible Recording of the Hilina Pali Excursion in the Mono Basin, California

    Science.gov (United States)

    Coe, R.; Liddicoat, J.

    2012-04-01

    Inclination of about negative 40˚ in basalt from Kilauea volcano, Hawaii (Teanby et al., 2002), that is assigned an age of about 18,000 radiocarbon years (uncorrected)(Coe et al., 1978, after Rubin and Berthold, 1961) and an excursion in northeastern China at Changbaishan Volcano of similar age from Ar40/Ar39 dates (Singer et al., 2011) that was interpreted to be the Blake Subchron (Zhu et al., 2000) using K/Ar (Liu, 1987) and Ar40/39 dates (Lin, 1999), might be recorded as shallow positive inclination in lacustrine siltstone in the bank of Wilson Creek in the Mono Basin, CA. The siltstone was deposited in Pleistocene Lake Russell, of which Mono Lake is the remnant, and was exposed when Wilson Creek was incised as the shoreline of Mono Lake receded (Lajoie, 1968). Basaltic and rhyolitic volcanic ash layers exposed in the bank of the creek are stratigraphic markers that have been important for studies of the Mono Lake Excursion (Denham and Cox, 1971; Liddicoat and Coe, 1979; Liddicoat, 1992; Coe and Liddicoat, 1994) and Pleistocene climate in the U.S. Great Basin (Zimmerman et al., 2006). Those ash layers likewise are useful for locating paleomagnetic directions along strike that might be the negative inclination in Hawaii named the Hilina Pali Excursion (Teanby et al., 2002). The portion of the lacustine section exposed along Wilson Creek that is of interest records waveform Delta in Lund et al. (1988) in Subunit E of Lajoie (1993) that is bracketed by ash layers 12 and 13; in Lajoie (1968), those ash layers are numbered 8 and 7, respectively. About midway in Subunit E, which has a thickness of 1.1 m, the inclination is about 15˚ in four back-to-back horizons that span 8 cm. The subsamples, each 2 cm thick, were treated by either alternating field or thermal demagnetization. The Virtual Geomagnetic Pole (VGP) for the horizon with the shallowest inclination (14.9˚) is 53.8˚ N, 22.7˚ E (n = 6, Alpha-95 = 2.3˚), and the VGPs within waveform Delta when followed

  6. Possible Recording of the Hilina Pali Excursion in Cored Tyrrhenian Sea Sediment

    Science.gov (United States)

    Iorio, Marina; Liddicoat, Joseph; Sagnotti, Leonardo; Incoronato, Alberto; de Anteriis, Giovanni; Insinga, Donatella; Angelino, Antimo

    2013-04-01

    First encountered in marine sediment cored from the Gulf of Mexico (19.5˚ N, 267.0˚ E)(Clark and Kennett, 1973), the Hilina Pali Excursion (HPE) is named for a locality in Hawaii (19.5˚ N, 205.0˚ E) where inclination of about negative 40˚ is documented in cored basalt (Teanby et al., 2002). Prior to naming the excursion, Coe et al. (1978) also found shallow inclination in basalt from Kilauea Volcano (19.2˚ N, 204.7˚ E) that is dated at about 18,000 yrs B.P. (uncorrected Carbon-14, Rubin and Berthold, 1961) - the age now assigned to the HPE - and was erupted when the field intensity was reduced to nearly half the present intensity. More recently, the HPE was located at Changbaishan Volcano in northeastern China (40.2˚ N, 128.0˚ E) where the age is established by Ar40/Ar39 dates (Singer et al., 2011). In exposed lake sediments in the Mono Basin, CA (38.0˚ N, 240.8˚ E), shallow positive inclination at about 18,000 yrs B.P. might also be the HPE. In the Mono Basin, normalized (NRM/ARM) intensity is reduced at that time (Zimmerman et al., 2006), and the Virtual Geomagnetic Poles (VGPs) during the reduced intensity form a clockwise trending loop when followed from old to young that descends to 53.8˚ N, 22.7˚ E (n = 6, Alpha-95 = 2.3˚) and is centered at about 50˚ N, 30˚ E (Coe and Liddicoat, 2012). There is a possible excursion of the palaeomagnetic field recorded in marine sediment at a locality in the Tyrrhenian Sea about 25 km south of Ischia (40.5˚ N, 13.7˚ E). The excursion is in sediment from two core segments that span about 22,000-18,000 yrs B.P. (de Alteriis et al., 2010) and occurs as reduced positive inclination (about 50˚) at about 20,000 yrs B.P. that increases to about 80˚ at about 18,000 yrs B.P. when declination changes from west to east. This pattern of field behaviour is similar to the behaviour of the possible HPE in the Mono Basin (Coe and Liddicoat, 2012) and in sediment cored from Lac du Bouchet, FR (44.9˚ N, 3.8˚ E) that is

  7. On the equivalence between the effective cosmology and excursion set treatments of environment

    CERN Document Server

    Martino, Matthew C

    2009-01-01

    In studies of the environmental dependence of structure formation, the large scale environment is often thought of as providing an effective background cosmology: e.g. the formation of structure in voids is expected to be just like that in a less dense universe with appropriately modified Hubble and cosmological constants. However, in the excursion set description of structure formation which is commonly used to model this effect, no explicit mention is made of the effective cosmology. Rather, this approach uses the spherical evolution model to compute an effective linear theory growth factor, which is then used to predict the growth and evolution of nonlinear structures. We show that these approaches are, in fact, equivalent: a consequence of Birkhoff's theorem. We speculate that this equivalence will not survive in models where the gravitational force law is modified from an inverse square, potentially making the environmental dependence of clustering a good test of such models.

  8. Five scientists on excursion — a picture of marine biology on Helgoland before 1892

    Science.gov (United States)

    Zissler, D.

    1995-03-01

    Five scientists on excursion — a picture of marine biology on Helgoland before 1892. The picture, of which several variant poses with minor differences exist, is a photograph taken on Helgoland in September, 1865. The original is to be found in the collections of the Ernst-Haeckel-Haus in Jena. The photograph shows only a few objects and fewer persons, but they are arranged like a bouquet: in front, collecting vessels; behind, grouped around a table, five scientists, Dohrn, Greeff, Haeckel, Salverda, Marchi. They hold up their catching nets like insignia, identifying their basic activity. This photograph is a unique document for the marine biological research on Helgoland before 1892. Furthermore, it illustrates a time and place for the birth of the idea of establishing the world's most famous marine biological station, the Stazione Zoologica di Napoli.

  9. Limnologic-geologic excursion in the territory of the lower Erft River

    Energy Technology Data Exchange (ETDEWEB)

    Friedrich, G.; Thome, K.N.

    1976-01-01

    The geography and hydrology of the area of the excursion are described. There is much damage due to brown coal strip mining operations. Ground water was drained through a canal leading to the Erft River. The water in nearby springs is rich in Fe which repels plant life. The canal contains only a few blue algae (Oscillatoria splendida) and filamentous green algae (Ulothrix tenerrima) which tolerate high Fe concentrations. The Erft shore plant population includes Sparganium erectum, Potamogeton natans, P. pectinatus and Ranunculus fluitans. On flowering plants and stones, diatoms, various green algae (Cladophora glomerata, Stigeoclonium tenue, Oedogonium capillare) and the tropical red alga Compsopogon hookeri were found. The macrozoobenthos is composed mainly of snails (Bithynia tenaculata, Lumnaea ovata, Physa fontinalis, P. acuta and worms of North American origin (Dugesia tifrina, Dendrocoelum lacteum and Planaria lugubris). The Isopoda included Asellus coxalis and A. aquaticus. Leeches (Herpobdella octoculata) and insect larvae (Chironomids, Limnephilids) were also found.

  10. Excursions in classical analysis pathways to advanced problem solving and undergraduate research

    CERN Document Server

    Chen, Hongwei

    2010-01-01

    Excursions in Classical Analysis introduces undergraduate students to advanced problem solving and undergraduate research in two ways. Firstly, it provides a colourful tour of classical analysis which places a wide variety of problems in their historical context. Secondly, it helps students gain an understanding of mathematical discovery and proof. In demonstrating a variety of possible solutions to the same sample exercise, the reader will come to see how the connections between apparently inapplicable areas of mathematics can be exploited in problem-solving. This book will serve as excellent preparation for participation in mathematics competitions, as a valuable resource for undergraduate mathematics reading courses and seminars and as a supplement text in a course on analysis. It can also be used in independent study, since the chapters are free-standing.

  11. Benchmarking of FLOWTRAN with Mark-22 mockup flow excursion test data from Babcock Wilcox

    Energy Technology Data Exchange (ETDEWEB)

    Chen, K.F.

    1991-11-01

    Version 16.2 of the FLOWTRAN code with a Savannah River Site (SRS) working criterion (St=0.00455) for the onset of significant void (OSV) was benchmarked against power and flow excursion data derived from tests at the Babcock Wilcox Alliance Research Center test facility. The analyses show that FLOWTRAN accurately predicts the mockup test assembly thermal-hydraulic behavior during the steady state and LOCA transient conditions, and that FLOWTRAN with a Savannah River Site (SRS) working limits criterion (St=0.00455) conservatively predicts the OFI power. Results for LOCA simulations which include a power decay transient for a safety rod SCRAM are shown below. For all of these tests, the calculated test assembly initial power or operating power limit was at least 15% below the initial power level for which the test assembly went into flow instability. These calculations were made using the SRS LOCA FI limits methodology ada ted to the test assembly.

  12. Benchmarking of FLOWTRAN with Mark-22 mockup flow excursion test data from Babcock & Wilcox

    Energy Technology Data Exchange (ETDEWEB)

    Chen, K.F.

    1991-11-01

    Version 16.2 of the FLOWTRAN code with a Savannah River Site (SRS) working criterion (St=0.00455) for the onset of significant void (OSV) was benchmarked against power and flow excursion data derived from tests at the Babcock & Wilcox Alliance Research Center test facility. The analyses show that FLOWTRAN accurately predicts the mockup test assembly thermal-hydraulic behavior during the steady state and LOCA transient conditions, and that FLOWTRAN with a Savannah River Site (SRS) working limits criterion (St=0.00455) conservatively predicts the OFI power. Results for LOCA simulations which include a power decay transient for a safety rod SCRAM are shown below. For all of these tests, the calculated test assembly initial power or operating power limit was at least 15% below the initial power level for which the test assembly went into flow instability. These calculations were made using the SRS LOCA FI limits methodology ada ted to the test assembly.

  13. Speleothems Recording Geomagnetic Excursions: a Case Study from Cobre Cave in Northern Spain

    Science.gov (United States)

    Pavon-Carrasco, F.; Osete, M. L.; Martin-chivelet, J.; Egli, R.; Rossi, C.; Muñoz-García, B.; Heller, F.

    2013-05-01

    Calcite speleothems, such as stalagmites and flowstones, have an enormous potential in palaeomagnetism, since they may grow continuously through thousands of years, the lock-in of remanent magnetisation is nearly instantaneous and ages of speleothems can be determined using high precision U-series radiometric dating techniques. However, the typically very low concentration of ferromagnetic minerals resulting in very weak natural remanent magnetisation (NRM) has limited their usage. In addition, secondary processes that could affect magnetization are poorly understood. Here we show results from a stalagmite from northern Spain (Cobre Cave) that recorded the Blake geomagnetic excursion. Two types of samples exhibiting different magnetic properties are observed. Isothermal remanent magnetisation (IRM) experiments indicate major contributions from low coercivity minerals in all samples. In white samples only ferrimagnetic minerals are detected whereas in light-brown samples variable amounts of high coercivity minerals can also be observed. The low coercivity IRM is thermally demagnetized at 550°C indicating the presence of magnetite. Maximum unblocking temperatures over 550°C of the high coercivity component suggest the additional presence of haematite in light-brown samples. Upon demagnetisation, all samples exhibited a directionally stable low-coercivity/low-unblocking temperature component that is considered as the characteristic remanent magnetisation (ChRM) carried by fine magnetite. The ChRM exhibited normal and reversed directions recording the Blake Geomagnetic Excursion which could be radiometrically dated between 116.5 ± 0.7 kyr BP and 112.0 ± 1.9 kyr BP. The second component carried by haematite has directions being always close to the present day field direction and is considered as a secondary component. Reliability of relative paleo-intensity (RPI) determinations is discussed.

  14. Assessing the duration and possible causes of the earliest Toarcian carbon isotopic excursion

    Science.gov (United States)

    Krencker, Francois-Nicolas; Bodin, Stéphane; Suan, Guillaume; Kabiri, Lahcen; Immenhauser, Adrian

    2013-04-01

    The early Toarcian stage (Early Jurassic) records two short-lived events of major faunal turnover and environmental perturbation. The first event (eT-E) occurs during the earliest Toarcian (early Polymorphum chronozone) and has been documented only in a few sites worldwide. The second event, better known as the Toarcian Oceanic Anoxic Event (T-OAE) has been documented in numerous sites from Northern Siberia to Argentina. Both events are marked by negative carbon isotope excursions (CIE) recorded in carbonate and organic substrate. Therefore they are thought to be associated with major changes in carbon cycling. Similarities between the eT-E and the T-OAE thus lead to the conclusion that these events might have been triggered by similar mechanisms. If this is the case, the CIEs associated with both events should have a comparable duration. In order to valid or falsify this hypothesis, it is therefore crucial to constrain the duration of both events. The duration of the T-OAE CIE was assessed in several papers by cyclostratigraphic analyses thanks to favourable outcropping condition. It is however not the case for the eT-E CIE, this latter being often associated with sedimentary condensation or hiatal surfaces. We make use of the high palaeo-subsidence rates of the Lower Toarcian Moroccan shelf leading to extended sections in the High Atlas Basin. The Foum Tillicht section was sampled in increments of 20 cm across a stratigraphic interval of 50 m, covering the Polymorphum chronozone. Carbon and oxygen isotopes analyses were performed on micritic and organic matter. Ammonites and nannofossils biostratigraphy aided in calibrating geochemical analyses. Carbon isotopes data display a rhythmic pattern. Preliminary results indicate that the eT-E negative carbon isotope excursion lasted around 400 kyr.

  15. The TRINITY Study: distribution of systolic blood pressure reductions

    Directory of Open Access Journals (Sweden)

    Sugimoto DH

    2013-07-01

    Full Text Available Danny H Sugimoto,1 Steven G Chrysant,2 Michael Melino,3 James Lee,3 Victor Fernandez,3 Reinilde Heyrman41Cedar-Crosse Research Center and Rush Medical College, Chicago, IL, USA; 2Oklahoma Cardiovascular and Hypertension Center and Department of Cardiology, University of Oklahoma College of Medicine, Oklahoma City, OK, USA; 3Department of Clinical Development, Daiichi Sankyo, Inc, Parsippany, NJ, USA; 4Formerly of the Department of Clinical Development, Daiichi Sankyo, Inc, Parsippany, NJ, USABackground: Elevated systolic blood pressure is more difficult to control than elevated diastolic blood pressure. The objective of this prespecified analysis of the Triple Therapy with Olmesartan Medoxomil, Amlodipine, and Hydrochlorothiazide in Hypertensive Patients Study (TRINITY was to compare the efficacy of olmesartan medoxomil (OM 40 mg, amlodipine besylate (AML 10 mg, and hydrochlorothiazide (HCTZ 25 mg triple-combination treatment with the component dual-combination treatments in reducing elevated seated systolic blood pressure (SeSBP.Methods: The 12-week TRINITY study randomized participants to either one of the three component dual-combination treatments (OM 40 mg/AML 10 mg, OM 40 mg/HCTZ 25 mg, or AML 10 mg/HCTZ 25 mg or the triple-combination treatment. The primary outcome of this analysis was the categorical distribution of SeSBP reductions at week 12 from baseline with OM 40 mg/AML 10 mg/HCTZ 25 mg versus the dual-combination treatments.Results: SeSBP reductions >50 mmHg were seen in 24.4% of participants receiving triple-combination treatment versus 8.1%–15.8% receiving dual-combination treatment. More participants receiving triple-combination treatment achieved the SeSBP target of <140 mmHg (73.6% versus 51.3%–58.8%; P < 0.001 and the seated blood pressure target of <140/90 mmHg (69.9% versus 41.1%–53.4%; P < 0.001. Prevalence and severity of adverse events were similar in all treatment groups.Conclusion: Treatment with OM 40 mg/AML 10

  16. The significance of an Early Jurassic (Toarcian) carbon-isotope excursion in Haida Gwaii (Queen Charlotte Islands), British Columbia, Canada

    Science.gov (United States)

    Caruthers, Andrew H.; Gröcke, Darren R.; Smith, Paul L.

    2011-07-01

    During the Early Toarcian there was a significant disruption in the short-term active carbon reservoir as revealed by carbon-isotope records, which show a broad positive shift that is interrupted by a large 5-7‰ negative excursion (δ 13C org). Carbon-isotope excursion co-occurs with the deposition of organic-rich shales in many areas. This perturbation in carbon isotopes is thought to be indicative of severe climate change and marine anoxia. The two leading hypotheses as to the cause of this event invoke either global or regional controls. Here we present carbon-isotope data from Haida Gwaii, British Columbia, Canada showing a significant perturbation within a temporally constrained Early Toarcian succession that was deposited in the northeastern paleo-Pacific Ocean. These data reinforce the concept that the short-term active carbon reservoir was affected globally, and assist with the correlation of ammonite zonal schemes between western North America and Europe. The δ 13C org data show a broad positive shift that is interrupted by a sharp and pronounced negative excursion of 7‰ (8.5‰ in δ 13C wood) in the Early Toarcian Kanense Zone. This negative excursion also coincides with increasing total organic carbon (TOC) from ~ 0.4% to ~ 1.2%. These data suggest that the Early Toarcian carbon-isotope perturbation was indeed global and imprinted itself on all active global reservoirs of the exchangeable carbon cycle (deep marine, shallow marine, atmospheric).

  17. Environmental impact and magnitude of paleosol carbonate carbon isotope excursions marking five early Eocene hyperthermals in the Bighorn Basin, Wyoming

    NARCIS (Netherlands)

    Abels, H.A.|info:eu-repo/dai/nl/304848018; Lauretano, V.; van Yperen, Anna E.; Hopman, Tarek; Zachos, J.C.; Lourens, L.J.|info:eu-repo/dai/nl/125023103; Gingerich, P.D.; Bowen, G.J.

    2016-01-01

    Transient greenhouse warming events in the Paleocene and Eocene were associated with the addition of isotopically light carbon to the exogenic atmosphere–ocean carbon system, leading to substantial environmental and biotic change. The magnitude of an accompanying carbon isotope excursion (CIE) can b

  18. The relationship between mean amplitude of glycemic excursions and cognitive impairment in elderly patients with type 2 diabetes

    Institute of Scientific and Technical Information of China (English)

    李新玲

    2013-01-01

    Objective To investigate the relationship between mean amplitude of glycemic excursions(MAGE) and cognitive impairment in elderly patients with type 2 diabetes. Methods Totally 80 patients(aged >60 years) with type 2 diabetes were selected. According to the Montreal

  19. Eyelid reanimation with gold weight implant and tendon sling suspension: evaluation of excursion and velocity using the FACIAL CLIMA system.

    Science.gov (United States)

    Hontanilla, Bernardo; Marre, Diego

    2013-04-01

    This study aims to analyse the efficacy of static techniques, namely gold weight implant and tendon sling, in the reanimation of the paralytic eyelid. Upper eyelid rehabilitation in terms of excursion and blinking velocity is performed using the automatic motion capture system, FACIAL CLIMA. Seventy-four patients underwent a total of 101 procedures including 58 upper eyelid gold weight implants and 43 lower eyelid tendon suspension with 27 patients undergoing both procedures. The presence of lagophtalmos, eye dryness, corneal ulcer, epiphora and lower lid ptosis/ectropion was assessed preoperatively. The Wilcoxon signed-rank test was used to compare preoperative versus postoperative measurements of upper eyelid excursion and blinking velocity determined with FACIAL CLIMA. Significance was set at p CLIMA revealed significant improvement of eyelid excursion and velocity of blinking (p CLIMA system is a reliable method to quantify upper eyelid excursion and blinking velocity and to detect the exact position of the lower eyelid. Copyright © 2012 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

  20. Automatic Identification of Systolic Time Intervals in Seismocardiogram

    Science.gov (United States)

    Shafiq, Ghufran; Tatinati, Sivanagaraja; Ang, Wei Tech; Veluvolu, Kalyana C.

    2016-11-01

    Continuous and non-invasive monitoring of hemodynamic parameters through unobtrusive wearable sensors can potentially aid in early detection of cardiac abnormalities, and provides a viable solution for long-term follow-up of patients with chronic cardiovascular diseases without disrupting the daily life activities. Electrocardiogram (ECG) and siesmocardiogram (SCG) signals can be readily acquired from light-weight electrodes and accelerometers respectively, which can be employed to derive systolic time intervals (STI). For this purpose, automated and accurate annotation of the relevant peaks in these signals is required, which is challenging due to the inter-subject morphological variability and noise prone nature of SCG signal. In this paper, an approach is proposed to automatically annotate the desired peaks in SCG signal that are related to STI by utilizing the information of peak detected in the sliding template to narrow-down the search for the desired peak in actual SCG signal. Experimental validation of this approach performed in conventional/controlled supine and realistic/challenging seated conditions, containing over 5600 heart beat cycles shows good performance and robustness of the proposed approach in noisy conditions. Automated measurement of STI in wearable configuration can provide a quantified cardiac health index for long-term monitoring of patients, elderly people at risk and health-enthusiasts.

  1. Central Systolic Hypertension in Patients with Well-Controlled Hypertension

    Science.gov (United States)

    Potočárová, Mária; Murín, Ján; Kozlíková, Katarína; Luha, Ján; Čaprnda, Martin

    2017-01-01

    Background. Central systolic blood pressure (CSBP) has prognostic significance and simplified devices for its estimation have been introduced recently. The aim of this study was to assess the achievement of the target CSBP in treated hypertensive patients. Subjects and Methods. One hundred patients with well-controlled hypertension were analysed. For CSBP estimation, we used the Arteriograph (TensioMed Ltd.), which uses one cuff for all measurements, the “single-point measurement” approach. Results. We found that 62% of patients had CSBP ≥ 130 mmHg, the suggested cut-off value for hypertension. When sex-specific classification was employed (CSBP ≥ 137 mmHg for female and CSBP ≥ 133 mmHg for male), only 13% of patients (mainly women) remained in the hypertensive range. We also found that 55% of patients had a CSBP higher than brachial pressure. Multiple analyses showed that CSBP was significantly associated with sex, height, and return time. Conclusions. A high proportion of treated hypertensive patients had CSBP levels that exceeded their brachial BP. CSBP positively correlated with lower height and shorter return time of the reflected pressure wave and was significantly higher in females compared to males. These findings suggest that, for CSBP classification, it is important to take height and sex-specific differences into account. PMID:28127560

  2. Paleomagnetic Excursions Recorded in the Yanchi Playa in Middle Hexi Corridor,NW China Since the Last Interglacial

    Institute of Scientific and Technical Information of China (English)

    YANG Taibao; YU Yongtao; LI Jijun; AN Congrong; LIU Jinfeng; ZHANG Junyan

    2004-01-01

    Paleomagnetic determinations on lithological profiles of two paralleled long drilling cores covering the past 130 kyr B.P., GT40 and GT60,from the Yanchi Playa in the arid Northwestern China,indicate that a series of pronounced paleomagnetic excursions have been documented. By correlating our results with published regional and worldwide reports,4 excursion events out of 10 apparent reversal signals (labeled from GT-1 to GT-10) were identified asexcursion events coeval with the Mono Lake Event (28.4 kyr~25.8 kyr), Laschamp Event (43.3 kyr~40.5kyr), Gaotai Event (8a.8 kyr~72.4 kyr) and the Blake Event (127.4 kyr~113.3 kyr), respectively. GT-9correlates with the above-mentioned Gaotai Event,GT-7 and GT-6 correspond to two stages of theLaschamp Event and GT-5 to the Mono Lake Event. It is noteworthy that the so-called Gaotai Event has not been reported as a pronounced paleomagnetic excursion in the Northwestern China. Every magnetic excursion event corresponds to paleointensity minima,anteceding those established abrupt paleoclimatic change events, such as the Younger Drays and the Heinrich Events(H1-H6). Here, we tentatively propose that these geomagnetic excursions/reversals can be viewed as precursors to climate abruptness.During the transitional stages when the earth's magnetic field shifted between a temporal normal and a negative period, the earth's magnetic paleointensity fell correspondingly to a pair of minima. Although more precise chronology and more convincing rock magnetic parameter determinations are essentially required for further interpretation of their intricate coupling mechanism, these results may have revealed, to some extent, that the earth's incessantly changing magnetic field exerts an strong influence on the onset of saw-tooth shaped abrupt climate oscillations through certain feedback chains in arid Central Asia or even North Hemispheric high latitude regions.

  3. The effect of a balance training programme on centre of pressure excursion in one-leg stance.

    Science.gov (United States)

    Verhagen, Evert; Bobbert, Maarten; Inklaar, Melanie; van Kalken, Marike; van der Beek, Allard; Bouter, Lex; van Mechelen, Willem

    2005-12-01

    Balance training is widely used in the rehabilitation after an ankle sprain and is thought to have a decreasing effect on postural sway. The present study investigated whether a 5.5-week balance training programme leads to a decreased postural sway showing in a reduced range of centre of pressure excursion. Thirty university students participated in this study. Twenty-two untrained subjects were randomly assigned to either an intervention group (n=11) or a control group (n=11). The remaining eight subjects were participants in an organized volleyball competition and were assigned to an additional volleyball group (n=8). All subjects of the intervention group and the volleyball group received a 5.5-week balance training programme, while subjects of the control group received no training. Centre of pressure of the ground reaction force was measured as a proxy measure of postural sway, using a force platform. Measurements took place before and after the 5.5-week training programme for standing on one leg (both for right and for left leg) of single leg stance, both for the eyes-open and eyes-closed situation. From these measurements centre of pressure excursion in the anterior-posterior and the medial-lateral direction was calculated. A linear regression analysis was performed to check for differences in centre of pressure excursion between any of the groups over the training period. No differences in changes of centre of pressure excursion were found between any of the groups over the 5.5-week training period. Balance training does not lead to a reduction in centre of pressure excursion in a general population consisting of non-injured and previously injured subjects.

  4. Impact of Glycemic Excursions on Left Ventricular Function of Patients with Acute Myocardial Infarction%血糖波动对急性心肌梗死患者左心室功能的影响研究

    Institute of Scientific and Technical Information of China (English)

    隋利军

    2016-01-01

    mmol/ L,n = 78)according to the mean amplitude of glycemic excursions. General information,laboratory examination results,index of cardiac function were compared between the two groups,and the impact of mean amplitude of glycemic excursions on left ventricular function was analyzed. Results No statistically significant differences of gender,age,BMI,positive rate of hypertension history,chronic obstructive pulmonary disease history or stroke history,SBP,DBP or heart rate was found between the two groups(P ﹥ 0. 05), while positive rate of diabetes of A group was statistically significantly lower than that of B group(P ﹤ 0. 05). No statistically significant differences of TC,TG,LDL-C,HDL-C or end - diastolic volume index was found between the two groups( P ﹥0. 05);FPG and HbA1c of A group was statistically significantly lower than that of B group,respectively end - systolic volume index was statistically significantly smaller than that of B group,LVEF and stroke volume of A group were statistically significantly higher than those of B group,Killip grading of A group was statistically significantly better than that of B group,while wall motion score index of A group was statistically significantly larger than that of B group( P ﹤ 0. 05). Multivariate logistic regression analysis results showed that,mean amplitude of glycemic excursions was one of risk factors of left ventricular function of patients with acute myocardial infarction〔 OR = 1. 567,95% CI(1. 021,2. 178),P ﹤ 0. 05 〕. Conclusion Glycemic excursions can affect the left ventricular function of patients with acute myocardial infarction,and mean amplitude of glycemic excursions is one of the risk factors of left ventricular function.

  5. Clinical usefulness of the second peak of radial systolic blood pressure for estimation of aortic systolic blood pressure.

    Science.gov (United States)

    Kohara, K; Tabara, Y; Tomita, H; Nagai, T; Igase, M; Miki, T

    2009-08-01

    Central aortic blood pressure (BP), obtained from radial arterial waveform using the transfer function method (TFM), has been shown to have prognostic value independently of brachial BP. In this study, the relationship between peripheral systolic BP (SBP) and aortic SBP was evaluated. We further investigated whether TFM-derived aortic SBP can be estimated by information obtained from the radial waveform. The radial waveform was analysed to obtain the first peak of radial SBP (SBP1), second peak of radial SBP (SBP2), radial augmentation index (AI) (radial (SBP2-DBP)/(SBP1-DBP) x 100 and aortic SBP and AI using TFM in 233 subjects in the supine position. Measurements were repeated after changing position to the prone position. The constructed equation was validated in 149 community residents with different backgrounds. Radial SBP2 was closer to TFM-derived aortic SBP compared with brachial SBP. TFM-derived aortic SBP was approximated by the equation: aortic SBP=18.9-radial SBP2-0.03 x HR-0.214 x radial AI (r2=0.992). The equation was also applicable to predicting aortic SBP in the prone position as well as in different populations (mean difference between predicted aortic SBP and TFM-derived aortic SBP: -0.01+/-1.34 and 1.05+/-1.47 mm Hg, respectively). Radial arterial waveform analysis can be used for estimation of TFM-derived aortic SBP.

  6. Familial and genomic analyses of postural changes in systolic and diastolic blood pressure.

    Science.gov (United States)

    Harrap, Stephen B; Cui, Jisheng S; Wong, Zilla Y H; Hopper, John L

    2004-03-01

    The physiological adaptation to the erect posture involves integrated neural and cardiovascular responses that might be determined by genetic factors. We examined the familial- and individual-specific components of variance for postural changes in systolic and diastolic blood pressure in 767 volunteer nuclear adult families from the Victorian Family Heart Study. In 274 adult sibling pairs, we made a genome-wide scan using 400 markers for quantitative trait loci linked with the postural changes in systolic and diastolic pressures. Overall, systolic pressure did not change on standing, but there was considerable variation in this phenotype (SD=8.1 mm Hg). Familial analyses revealed that 25% of the variance of change in systolic pressure was attributable to genetic factors. In contrast, diastolic pressure increased by 6.3 mm Hg (SD=7.0 mm Hg) on standing and there was no evidence of contributory genetic factors. Multipoint quantitative genome linkage mapping suggested evidence (Z=3.2) of linkage of the postural change in systolic pressure to chromosome 12 but found no genome-wide evidence of linkage for the change in diastolic pressure. These findings suggest that genetic factors determine whether systolic pressure decreases or increases when one stands, possibly as the result of unidentified alleles on chromosome 12. The genetics of postural changes in systolic blood pressure might reflect the general buffering function of the baroreflex; thereby, the predisposition to sudden decreases or increases in systolic pressure might cause postural hypotension or vessel wall disruption, respectively.

  7. Oscillometric measurement of systolic and diastolic blood pressures validated in a physiologic mathematical model

    Directory of Open Access Journals (Sweden)

    Babbs Charles F

    2012-08-01

    Full Text Available Abstract Background The oscillometric method of measuring blood pressure with an automated cuff yields valid estimates of mean pressure but questionable estimates of systolic and diastolic pressures. Existing algorithms are sensitive to differences in pulse pressure and artery stiffness. Some are closely guarded trade secrets. Accurate extraction of systolic and diastolic pressures from the envelope of cuff pressure oscillations remains an open problem in biomedical engineering. Methods A new analysis of relevant anatomy, physiology and physics reveals the mechanisms underlying the production of cuff pressure oscillations as well as a way to extract systolic and diastolic pressures from the envelope of oscillations in any individual subject. Stiffness characteristics of the compressed artery segment can be extracted from the envelope shape to create an individualized mathematical model. The model is tested with a matrix of possible systolic and diastolic pressure values, and the minimum least squares difference between observed and predicted envelope functions indicates the best fit choices of systolic and diastolic pressure within the test matrix. Results The model reproduces realistic cuff pressure oscillations. The regression procedure extracts systolic and diastolic pressures accurately in the face of varying pulse pressure and arterial stiffness. The root mean squared error in extracted systolic and diastolic pressures over a range of challenging test scenarios is 0.3 mmHg. Conclusions A new algorithm based on physics and physiology allows accurate extraction of systolic and diastolic pressures from cuff pressure oscillations in a way that can be validated, criticized, and updated in the public domain.

  8. Evaluation of Right Ventricular Systolic Function in Chagas Disease Using Cardiac Magnetic Resonance Imaging.

    Science.gov (United States)

    Moreira, Henrique T; Volpe, Gustavo J; Marin-Neto, José A; Ambale-Venkatesh, Bharath; Nwabuo, Chike C; Trad, Henrique S; Romano, Minna M D; Pazin-Filho, Antonio; Maciel, Benedito C; Lima, João A C; Schmidt, André

    2017-03-01

    Right ventricular (RV) impairment is postulated to be responsible for prominent systemic congestion in Chagas disease. However, occurrence of primary RV dysfunction in Chagas disease remains controversial. We aimed to study RV systolic function in patients with Chagas disease using cardiac magnetic resonance. This cross-sectional study included 158 individuals with chronic Chagas disease who underwent cardiac magnetic resonance. RV systolic dysfunction was defined as reduced RV ejection fraction based on predefined cutoffs accounting for age and sex. Multivariable logistic regression was used to verify the relationship of RV systolic dysfunction with age, sex, functional class, use of medications for heart failure, atrial fibrillation, and left ventricular systolic dysfunction. Mean age was 54±13 years, 51.2% men. RV systolic dysfunction was identified in 58 (37%) individuals. Although usually associated with reduced left ventricular ejection fraction, isolated RV systolic dysfunction was found in 7 (4.4%) patients, 2 of them in early stages of Chagas disease. Presence of RV dysfunction was not significantly different in patients with indeterminate/digestive form of Chagas disease (35.7%) compared with those with Chagas cardiomyopathy (36.8%) (P=1.000). In chronic Chagas disease, RV systolic dysfunction is more commonly associated with left ventricular systolic dysfunction, although isolated and early RV dysfunction can also be identified. © 2017 American Heart Association, Inc.

  9. Prognostic significance of cardiovascular biomarkers and renal dysfunction in outpatients with systolic heart failure

    DEFF Research Database (Denmark)

    Bosselmann, Helle; Egstrup, Michael; Rossing, Kasper

    2013-01-01

    To assess whether the prognostic significance of cardiovascular (CV) biomarkers, is affected by renal dysfunction (RD) in systolic heart failure (HF).......To assess whether the prognostic significance of cardiovascular (CV) biomarkers, is affected by renal dysfunction (RD) in systolic heart failure (HF)....

  10. Exercise training in older patients with systolic heart failure: Adherence, exercise capacity, inflammation and glycemic control

    DEFF Research Database (Denmark)

    Prescott, Eva; Hjardem-Hansen, Rasmus; Dela, Flemming

    2009-01-01

    Objectives. Training improves exercise capacity in patients with heart failure (CHF) but most evidence is on selected younger patients with systolic CHF. Design. All patients diagnosed with CHF over 3 years were screened for inclusion and exclusion criteria. Fifty two patients with systolic CHF...

  11. Use of Inotropic Agents in Treatment of Systolic Heart Failure.

    Science.gov (United States)

    Tariq, Sohaib; Aronow, Wilbert S

    2015-12-04

    The most common use of inotropes is among hospitalized patients with acute decompensated heart failure, with reduced left ventricular ejection fraction and with signs of end-organ dysfunction in the setting of a low cardiac output. Inotropes can be used in patients with severe systolic heart failure awaiting heart transplant to maintain hemodynamic stability or as a bridge to decision. In cases where patients are unable to be weaned off inotropes, these agents can be used until a definite or escalated supportive therapy is planned, which can include coronary revascularization or mechanical circulatory support (intra-aortic balloon pump, extracorporeal membrane oxygenation, impella, left ventricular assist device, etc.). Use of inotropic drugs is associated with risks and adverse events. This review will discuss the use of the inotropes digoxin, dopamine, dobutamine, norepinephrine, milrinone, levosimendan, and omecamtiv mecarbil. Long-term inotropic therapy should be offered in selected patients. A detailed conversation with the patient and family shall be held, including a discussion on the risks and benefits of use of inotropes. Chronic heart failure patients awaiting heart transplants are candidates for intravenous inotropic support until the donor heart becomes available. This helps to maintain hemodynamic stability and keep the fluid status and pulmonary pressures optimized prior to the surgery. On the other hand, in patients with severe heart failure who are not candidates for advanced heart failure therapies, such as transplant and mechanical circulatory support, inotropic agents can be used for palliative therapy. Inotropes can help reduce frequency of hospitalizations and improve symptoms in these patients.

  12. Severe systolic hypertension and the search for safer motherhood.

    Science.gov (United States)

    Martin, James N

    2016-03-01

    Timely and appropriate response to severe hypertension during gestation is an important component of quality, safe care for pregnant or puerperal mothers regardless of causation. The reduction of severe maternal morbidity and maternal mortality in the hypertensive mother is clearly enhanced by the addition of standard protocols for provider response to severe hypertension, particularly severe systolic hypertension. The program developed in New York State via the Safe Motherhood Initiative promotes the implementation of unit-specific safety bundles, especially one that is focused upon a standardized approach to handling the obstetric emergency of severe hypertension usually associated with preeclampsia/eclampsia. The comprehensive preeclampsia/eclampsia safety bundle as summarized by Drs. Moroz and colleagues is reviewed especially from the perspective of its focus on the timely and specific responses for health care providers to make when severe hypertension is detected in the pregnant patient. Evidence-based guidance to practice considerations and clinical care of patients with preeclampsia/eclampsia is embedded within the program outlined for New York State by Moroz and her District II ACOG colleagues. There is a central focus on timely and appropriate antepartum/postpartum management of severe hypertension, a core concept to lessen maternal risk for cerebral hemorrhage. Ten considerations for further integration into the New York program are suggested. Beyond blood pressure control, there is a need for systematic review of interventions and outcomes over time, attention to possible future variations of the protocol for racial/ethnic patient groups at highest risk for maternal morbidity and mortality, and the identification of biomarker(s) that further specify and quantify risk to the maternal brain and other organ systems when severe hypertension develops. Safer motherhood will happen when evidence for best practice is integrated into systems of care for all

  13. Systolic blood pressure and short-term mortality in the emergency department and prehospital setting

    DEFF Research Database (Denmark)

    Kristensen, Anders Kasper Bruun; Holler, Jon Gitz; Mikkelsen, Søren;

    2015-01-01

    staffed mobile emergency care unit in Odense between 2007 and 2013. We used the first recorded systolic blood pressure and the main outcome was 7-day mortality. Best performing thresholds were identified with methods based on receiver operating characteristics (ROC) and multivariate regression......INTRODUCTION: Systolic blood pressure is a widely used tool to assess circulatory function in acutely ill patients. The systolic blood pressure limit where a given patient should be considered hypotensive is the subject of debate and recent studies have advocated higher systolic blood pressure...... thresholds than the traditional 90 mmHg. The aim of this study was to identify the best performing systolic blood pressure thresholds with regards to predicting 7-day mortality and to evaluate the applicability of these in the emergency department as well as in the prehospital setting. METHODS...

  14. In vivo adaptive response of the peripheral conduit artery in patients with borderline systolic hypertension

    Institute of Scientific and Technical Information of China (English)

    陶军; 靳亚非; 王礼春; 唐安丽; 廖新学; 杨震; 马虹

    2003-01-01

    Objective To investigate elastic changes of the radial artery, a medium-sized muscular peripheral conduit artery, in patients with borderline systolic hypertension. Methods Using a non-invasive high-resolution echo-tracking device coupled to a photoplethysmography (Finapres system) allowing simultaneous arterial diameter and finger blood pressure monitoring, we measured radial artery elastic parameters of 20 patients with borderline systolic hypertension and 20 normal subjects according to Langewouters model.Results The diameter of the radial artery of control subjects and those with borderline systolic hypertension at the isobaric level of 100 mmHg and mean arterial pressure was similar, but the compliance and distensibility at similar conditions in patients with borderline systolic hypertension did not further reduced and even increased. Conclusion In patients with borderline systolic hypertension, the adaptive responses of the radial artery compliance and distensibility to increased pressure were directed to maintain its elasticity, contributing to the homeostasis of the cardiovascular system.

  15. Physiological Responses Associated with Nordic-Walking Training in Systolic Hypertensive Postmenopausal Women

    Directory of Open Access Journals (Sweden)

    Latosik Ewelina

    2014-12-01

    Full Text Available Loss of physical strength and hypertension are among the most pronounced detrimental factors accompanying aging. The aim of this study was to evaluate the influence of a supervised 8-week Nordic-walking training program on systolic blood pressure in systolic-hypertensive postmenopausal women. This study was a randomized control trial on a sample of 24 subjects who did not take any hypertension medications. There was a statistically significant decrease in systolic blood pressure and an increase in lower and upper-body strength in the group following Nordic-walking training. There was a decrease in serum levels of total cholesterol, triglycerides, and low-density cholesterol. The obtained results indicate that an 8-week Nordic-walking program may be efficiently employed for counteracting systolic hypertension through a direct abatement of systolic blood pressure and an increase of maximal aerobic capacity.

  16. Effect of Visit‐to‐Visit Variation of Heart Rate and Systolic Blood Pressure on Outcomes in Chronic Systolic Heart Failure: Results From the Systolic Heart Failure Treatment With the I f Inhibitor Ivabradine Trial (SHIFT) Trial

    OpenAIRE

    Böhm, Michael; Robertson, Michele; Borer, Jeffrey; Ford, Ian; Komajda, Michel; Mahfoud, Felix; Ewen, Sebastian; Swedberg, Karl; Tavazzi, Luigi

    2016-01-01

    Background Elevated resting heart rate (HR) and low systolic blood pressure (SBP) are related to poor outcomes in heart failure (HF). The association between visit‐to‐visit variation in SBP and HR and risk in HF is unknown. Methods and Results In Systolic Heart Failure Treatment with the I f inhibitor ivabradine Trial (SHIFT) patients, we evaluated relationships between mean HR, mean SBP, and visit‐to‐visit variations (coefficient of variation [CV]=SD/mean×100%) in SBP and HR (SBP‐CV and HR‐C...

  17. Rapid directional changes associated with a 6.5 kyr-long Blake geomagnetic excursion at the Blake-Bahama Outer Ridge

    DEFF Research Database (Denmark)

    Bourne, Mark; McNiocaill, Conall; Thomas, Alexander;

    2012-01-01

    Geomagnetic excursions are recognized as intrinsic features of the Earth's magnetic field. High-resolution records of field behaviour, captured in marine sedimentary cores, present an opportunity to determine the temporal and geometric character of the field during geomagnetic excursions and prov......Geomagnetic excursions are recognized as intrinsic features of the Earth's magnetic field. High-resolution records of field behaviour, captured in marine sedimentary cores, present an opportunity to determine the temporal and geometric character of the field during geomagnetic excursions...... and provide constraints on the mechanisms producing field variability. We present here the highest resolution record yet published of the Blake geomagnetic excursion (similar to 125 ka) measured in three cores from Ocean Drilling Program (ODP) Site 1062 on the Blake-Bahama Outer Ridge. The Blake excursion has...... a controversial structure and timing but these cores have a sufficiently high sedimentation rate (similar to 10 cm ka(-1)) to allow detailed reconstruction of the field behaviour at this site during the excursion. Palaeomagnetic measurements of the cores reveal rapid transitions (

  18. Arnold's Projective Plane and -Matrices

    Directory of Open Access Journals (Sweden)

    K. Uchino

    2010-01-01

    Full Text Available We will explain Arnold's 2-dimensional (shortly, 2D projective geometry (Arnold, 2005 by means of lattice theory. It will be shown that the projection of the set of nontrivial triangular -matrices is the pencil of tangent lines of a quadratic curve on Arnold's projective plane.

  19. Affine Contractions on the Plane

    Science.gov (United States)

    Celik, D.; Ozdemir, Y.; Ureyen, M.

    2007-01-01

    Contractions play a considerable role in the theory of fractals. However, it is not easy to find contractions which are not similitudes. In this study, it is shown by counter examples that an affine transformation of the plane carrying a given triangle onto another triangle may not be a contraction even if it contracts edges, heights or medians.…

  20. Distributed storage in the plane

    NARCIS (Netherlands)

    Altman, Eitan; Avrachenkov, Konstatin; Goseling, Jasper

    2013-01-01

    We consider storage devices located in the plane according to a general point process and specialize the results for the homogeneous Poisson process. A large data file is stored at the storage devices, which have limited storage capabilities. Hence, they can only store parts of the data. Clients can

  1. Distributed storage in the plane

    NARCIS (Netherlands)

    Altman, Eitan; Avrachenkov, Konstatin; Goseling, Jasper

    2014-01-01

    We consider storage devices located in the plane according to a general point process and specialize the results for the homogeneous Poisson process. A large data file is stored at the storage devices, which have limited storage capabilities. Hence, they can only store parts of the data. Clients can

  2. Plane and parabolic solar panels

    CERN Document Server

    Sales, J H O

    2009-01-01

    We present a plane and parabolic collector that absorbs radiant energy and transforms it in heat. Therefore we have a panel to heat water. We study how to increment this capture of solar beams onto the panel in order to increase its efficiency in heating water.

  3. Distributed storage in the plane

    NARCIS (Netherlands)

    Altman, Eitan; Avrachenkov, Konstatin; Goseling, Jasper

    2013-01-01

    We consider storage devices located in the plane according to a general point process and specialize the results for the homogeneous Poisson process. A large data file is stored at the storage devices, which have limited storage capabilities. Hence, they can only store parts of the data. Clients can

  4. Distributed storage in the plane

    NARCIS (Netherlands)

    Altman, Eitan; Avrachenkov, Konstatin; Goseling, Jasper

    2014-01-01

    We consider storage devices located in the plane according to a general point process and specialize the results for the homogeneous Poisson process. A large data file is stored at the storage devices, which have limited storage capabilities. Hence, they can only store parts of the data. Clients can

  5. Valuation of Normal Range of Ankle Systolic Blood Pressure in Subjects with Normal Arm Systolic Blood Pressure.

    Directory of Open Access Journals (Sweden)

    Yi Gong

    Full Text Available This study aimed to establish a normal range for ankle systolic blood pressure (SBP.A total of 948 subjects who had normal brachial SBP (90-139 mmHg at investigation were enrolled. Supine BP of four limbs was simultaneously measured using four automatic BP measurement devices. The ankle-arm difference (An-a on SBP of both sides was calculated. Two methods were used for establishing normal range of ankle SBP: the 99% method was decided on the 99% reference range of actual ankle BP, and the An-a method was the sum of An-a and the low or up limits of normal arm SBP (90-139 mmHg.Whether in the right or left side, the ankle SBP was significantly higher than the arm SBP (right: 137.1 ± 16.9 vs 119.7 ± 11.4 mmHg, P<0.05. Based on the 99% method, the normal range of ankle SBP was 94~181 mmHg for the total population, 84~166 mmHg for the young (18-44 y, 107~176 mmHg for the middle-aged(45-59 y and 113~179 mmHg for the elderly (≥ 60 y group. As the An-a on SBP was 13 mmHg in the young group and 20 mmHg in both middle-aged and elderly groups, the normal range of ankle SBP on the An-a method was 103-153 mmHg for young and 110-160 mmHg for middle-elderly subjects.A primary reference for normal ankle SBP was suggested as 100-165 mmHg in the young and 110-170 mmHg in the middle-elderly subjects.

  6. Habitat Demonstration Unit (HDU) Pressurized Excursion Module (PEM) Systems Integration Strategy

    Science.gov (United States)

    Gill, Tracy; Merbitz, Jerad; Kennedy, Kriss; Tri, Terry; Toups, Larry; Howe, A. Scott

    2011-01-01

    The Habitat Demonstration Unit (HDU) project team constructed an analog prototype lunar surface laboratory called the Pressurized Excursion Module (PEM). The prototype unit subsystems were integrated in a short amount of time, utilizing a rapid prototyping approach that brought together over 20 habitation-related technologies from a variety of NASA centers. This paper describes the system integration strategies and lessons learned, that allowed the PEM to be brought from paper design to working field prototype using a multi-center team. The system integration process was based on a rapid prototyping approach. Tailored design review and test and integration processes facilitated that approach. The use of collaboration tools including electronic tools as well as documentation enabled a geographically distributed team take a paper concept to an operational prototype in approximately one year. One of the major tools used in the integration strategy was a coordinated effort to accurately model all the subsystems using computer aided design (CAD), so conflicts were identified before physical components came together. A deliberate effort was made following the deployment of the HDU PEM for field operations to collect lessons learned to facilitate process improvement and inform the design of future flight or analog versions of habitat systems. Significant items within those lessons learned were limitations with the CAD integration approach and the impact of shell design on flexibility of placing systems within the HDU shell.

  7. Development of a Bayesian Belief Network Runway Incursion and Excursion Model

    Science.gov (United States)

    Green, Lawrence L.

    2014-01-01

    In a previous work, a statistical analysis of runway incursion (RI) event data was conducted to ascertain the relevance of this data to the top ten Technical Challenges (TC) of the National Aeronautics and Space Administration (NASA) Aviation Safety Program (AvSP). The study revealed connections to several of the AvSP top ten TC and identified numerous primary causes and contributing factors of RI events. The statistical analysis served as the basis for developing a system-level Bayesian Belief Network (BBN) model for RI events, also previously reported. Through literature searches and data analysis, this RI event network has now been extended to also model runway excursion (RE) events. These RI and RE event networks have been further modified and vetted by a Subject Matter Expert (SME) panel. The combined system-level BBN model will allow NASA to generically model the causes of RI and RE events and to assess the effectiveness of technology products being developed under NASA funding. These products are intended to reduce the frequency of runway safety incidents/accidents, and to improve runway safety in general. The development and structure of the BBN for both RI and RE events are documented in this paper.

  8. Scope Complexity Options Risks Excursions (SCORE) Version 3.0 Mathematical Description.

    Energy Technology Data Exchange (ETDEWEB)

    Gearhart, Jared Lee [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Samberson, Jonell Nicole [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Shettigar, Subhasini [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jungels, John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Welch, Kimberly M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jones, Dean A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-03-01

    The purpose of the Scope, Complexity, Options, Risks, Excursions (SCORE) model is to estimate the relative complexity of design variants of future warhead options. The results of this model allow those considering these options to understand the complexity tradeoffs between proposed warhead options. The core idea of SCORE is to divide a warhead option into a well- defined set of scope elements and then estimate the complexity of each scope element against a well understood reference system. The uncertainty associated with estimates can also be captured. A weighted summation of the relative complexity of each scope element is used to determine the total complexity of the proposed warhead option or portions of the warhead option (i.e., a National Work Breakdown Structure code). The SCORE analysis process is a growing multi-organizational Nuclear Security Enterprise (NSE) effort, under the management of the NA- 12 led Enterprise Modeling and Analysis Consortium (EMAC), that has provided the data elicitation, integration and computation needed to support the out-year Life Extension Program (LEP) cost estimates included in the Stockpile Stewardship Management Plan (SSMP).

  9. Accidental nuclear excursion recuplex operation 234-5 facility: Final medical report

    Energy Technology Data Exchange (ETDEWEB)

    Fuqua, P. A.

    1962-04-07

    The April 7, 1962 criticality accident involving human exposures was the first to have occurred in any production facility at Hanford. The accidental nuclear excursion did not result in any mechanical damage or spread of contamination. Three employees received over-exposure to gamma and neutron radiation. None were fatally exposed and in each case the over-exposure was recognized promptly. Following an initial period of medical observation and testing, the men were released to work. They continued to be followed clinically. Clinical studies performed were hematological procedures including leukocyte chromosome aberrations, morphologically aberrant blood cells, bone marrow evaluations, blood chemistry determinations, amino acid excretion studies, seminal fluid, urinary gonadotropins and estrogen excretion studies, testicular biopsies and crystalline lens examinations. These studies, along with a brief description of the accident and of the dosimetry, are summarized in this report by those participating in the studies. In view of the dose ranges received in these cases, both the negative and positive findings are considered to be of unusual interest due to the lack of knowledge of effects following human exposures at these levels.

  10. An Excursion-Set Model for the Structure of GMCs and the ISM

    CERN Document Server

    Hopkins, Philip F

    2012-01-01

    The ISM is governed by supersonic turbulence on a range of scales. We use this to develop a rigorous excursion-set model for the formation and time evolution of dense gas structures (GMCs, massive clumps, and cores). Supersonic turbulence drives the density distribution to a lognormal with dispersion increasing with Mach number; we generalize this to include scales >h (the disk scale height), and use it to construct the statistical properties of the density field smoothed on a scale R. We then compare conditions for self-gravitating collapse including thermal, turbulent, and rotational support. We show this becomes a well-defined barrier crossing problem. As such, an exact 'bound object mass function' can be derived, from scales of the sonic length to above the disk Jeans mass. This agrees remarkably well with observed GMC mass functions in the MW and other galaxies; the only inputs are the mass and size of the galaxies (to normalize the model). This explains the mass function cutoff and its power-law slope (...

  11. Condyle Excursion Angle, Articular Eminence Inclination, and Temporomandibular Joint Morphologic Relations With Disc Displacement.

    Science.gov (United States)

    Rabelo, Katharina Alves; Sousa Melo, Saulo Leonardo; Torres, Marianna Guanaes Gomes; Campos, Paulo Sérgio F; Bento, Patrícia Meira; Melo, Daniela Pita de

    2017-05-01

    The aim of this study was to evaluate the relations of the condyle excursion angle (CEA) and the morphology and morphometry of the articular eminence to disc displacement (DD) using magnetic resonance imaging (MRI) of symptomatic patients. MRIs of 199 temporomandibular joints (TMJs) were evaluated. Qualitative and quantitative morphologic analyses were performed with tools available in PACS 11.0 (Carestream Health, Inc, Rochester, NY). The articular eminence inclination (AEI), eminence height (EH), CEA, and articular eminence morphologic shape were evaluated. Statistical analyses were used to evaluate any possible association of the variables with DD in the closed- and open-mouth positions, age, and gender. The significance level was set at .05. Elderly women (>60 yr) presented higher prevalence values (43.26%). There was no statistical correlation between DD and gender (P = .4290). Higher mean values of the AEI and EH were associated with box-shaped eminences. The EH, AEI, and CEA were not related to the presence or absence of DD and the different types of DD. The AEI (P = .002) and CEA (P < .001) values were higher for TMJs with disc reduction in the open-mouth position. Disc position in the closed- and open-mouth positions is not influenced by articular eminence morphology; however, the AEI and CEA have an influence on disc reduction. Copyright © 2017 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  12. The Dynamics of Rapid Redshifted and Blueshifted Excursions in the Solar Halpha line

    CERN Document Server

    Kuridze, D; Mathioudakis, M; Erdélyi, R; Zaqarashvili, T V; Shelyag, S; Keys, P H; Keenan, F P

    2015-01-01

    We analyse high temporal and spatial resolution time-series of spectral scans of the Halpha line obtained with the CRisp Imaging SpectroPolarimeter (CRISP) instrument mounted on the Swedish Solar Telescope. The data reveal highly dynamic, dark, short-lived structures known as Rapid Redshifted and Blueshifted Excursions (RREs, RBEs) that are on-disk absorption features observed in the red and blue wings of spectral lines formed in the chromosphere. We study the dynamics of RREs and RBEs by tracking their evolution in space and time, measuring the speed of the apparent motion, line-of-sight Doppler velocity, and transverse velocity of individual structures. A statistical study of their measured properties shows that RREs and RBEs have similar occurrence rates, lifetimes, lengths, and widths. They also display non-periodic, non-linear transverse motions perpendicular to their axes at speeds of 4 - 31 km/s. Furthermore, both types of structures either appear as high speed jets and blobs that are directed outwardl...

  13. Improved Right Ventricular Performance with Increased Tricuspid Annular Excursion in Athlete’s Heart

    Directory of Open Access Journals (Sweden)

    Himanshu eGupta

    2015-04-01

    Full Text Available Background: Marathon runners (MTH and patients with mitral regurgitation (MR exhibit left ventricular (LV overload, and LV geometric changes in these groups have been reported. In this study, right ventricular (RV adaptation to chronic volume overload was evaluated in MTH and MR and normal controls together with interventricular septal remodeling and tricuspid annulus (TA motion. Methods: A total of 60 age-matched subjects (including 19 MTH, 17 isolated chronic compensated MR patients and 24 normal subjects underwent conventional cine and tagged cardiac magnetic resonance imaging. Myocardial strain and curvature were computed on the interventricular septum and RV free wall. A dual-propagation technique was applied to construct RV volume-time curves for a single cardiac cycle. Similarly, the tricuspid annulus was tracked throughout the cardiac cycle to create displacement over time curve.Results: Septal curvature was significantly lower in MTH and MR compared to controls. No significant differences in RV free wall strain or RV ejection fraction were noted amongst the 3 groups. However, longitudinal TA excursion was significantly higher in MTH compared to controls (p=0.0061. The peak late diastolic TA velocity in MR was significantly faster than MTH (p=0.0031 and controls (p=0.020. Conclusions: Increased TA kinetics allows for improved RV performance in MTH. Septal remodeling was observed in both MR and MTH, therefore a direct relationship of septal remodeling to TA kinetics in athlete’s heart could not be elucidated in this study.

  14. Star Excursion Balance Test performance and application in elite junior rugby union players.

    Science.gov (United States)

    Coughlan, Garrett F; Delahunt, Eamonn; O'Sullivan, Eoghan; Fullam, Karl; Green, Brian S; Caulfield, Brian M

    2014-11-01

    To evaluate performance on selected reach directions of the Start Excursion Balance Test (SEBT) in an elite underage rugby union population, and determine if differences exist between the forward and back position units. This information may have implications for the application of this test in player injury prevention and management. Descriptive study. Gymnasium at an elite junior rugby union screening camp. 102 healthy male elite rugby union players (age = 17.9 ± 1.1 years, height = 1.83 ± 0.07 m, body mass = 90.5 ± 11.3 kg). Participants were assessed on the Anterior (A), Posterior-medial (PM), and Posterior-lateral (PL) reach directions of the SEBT. Normative data for SEBT performance in the A, PM and PL reach directions were established for an elite junior rugby union population. No significant differences in dynamic postural stability were observed between the forward and back position units. This study provides normative SEBT data on an elite junior rugby union population, which enables clinicians to compare player dynamic postural stability and has implications for use in the prevention and management of player injuries. Copyright © 2013 Elsevier Ltd. All rights reserved.

  15. Fixed field alternating gradient accelerator with small orbit shift and tune excursion

    Directory of Open Access Journals (Sweden)

    Suzanne L. Sheehy

    2010-04-01

    Full Text Available A new design principle of a nonscaling fixed field alternating gradient accelerator is proposed. It is based on optics that produce approximate scaling properties. A large field index k is chosen to squeeze the orbit shift as much as possible by setting the betatron oscillation frequency in the second stability region of Hill’s equation. Then, the lattice magnets and their alignment are simplified. To simplify the magnets, we expand the field profile of r^{k} into multipoles and keep only a few lower order terms. A rectangular-shaped magnet is assumed with lines of constant field parallel to the magnet axis. The lattice employs a triplet of rectangular magnets for focusing, which are parallel to one another to simplify alignment. These simplifications along with fringe fields introduce finite chromaticity and the fixed field alternating gradient accelerator is no longer a scaling one. However, the tune excursion of the whole ring can be within half an integer and we avoid the crossing of strong resonances.

  16. Constrained simulations and excursion sets: understanding the risks and benefits of `genetically modified' haloes

    Science.gov (United States)

    Porciani, Cristiano

    2016-12-01

    Constrained realizations of Gaussian random fields are used in cosmology to design special initial conditions for numerical simulations. We review this approach and its application to density peaks providing several worked-out examples. We then critically discuss the recent proposal to use constrained realizations to modify the linear density field within and around the Lagrangian patches that form dark-matter haloes. The ambitious concept is to forge `genetically modified' haloes with some desired properties after the non-linear evolution. We demonstrate that the original implementation of this method is not exact but approximate because it tacitly assumes that protohaloes sample a set of random points with a fixed mean overdensity. We show that carrying out a full genetic modification is a formidable and daunting task requiring a mathematical understanding of what determines the biased locations of protohaloes in the linear density field. We discuss approximate solutions based on educated guesses regarding the nature of protohaloes. We illustrate how the excursion-set method can be adapted to predict the non-linear evolution of the modified patches and thus fine tune the constraints that are necessary to obtain pre-selected halo properties. This technique allows us to explore the freedom around the original algorithm for genetic modification. We find that the quantity which is most sensitive to changes is the halo mass-accretion rate at the mass scale on which the constraints are set. Finally, we discuss constraints based on the protohalo angular momenta.

  17. New Radiometric Age Constraints for the Matuyama-Bruhnes Reversal and Santa Rosa Excursion

    Science.gov (United States)

    Balbas, A.; Koppers, A. A. P.; Kent, D. V.; Coe, R. S.; Konrad, K.; Clark, P. U.

    2015-12-01

    The coupling of the timing of the virtual geomagnetic pole (VGP) position and the absolute paleointensities for geomagnetic events is vital for understanding the Earth's geodynamo. Here we present new high-precision 40Ar/39Ar age determinations using an ARGUS-VI multi-collector mass spectrometer for lava flows on Floreana Island, Galapagos, and Tahiti Nui, Society Islands. New Galapagos ages (n=6) place the GA-79 lava flow on Floreana Island, which records an excursional VGP from an equatorial region (Cox and Dalrymple, 1966), within the Santa Rosa excursion. This flow contains extremely low paleointesity values of 1.1 x 1022 Am2 (n=11; Wang and Kent, 2013). We also present 52 new ages on 18 lava flows from the Punaruu valley, Tahiti, which record the Matuyama-Bruhnes reversal. The new ages confirm that the lavas record this reversal, but the ages differ from the original stratigraphy presented in Mochizuki et al. (2011). Our new ages using the Kuiper et al. (2008) fish canyon sanidine ages for Punaruu valley lava flows are concordant with previous astronomically tuned ages (Channell et al. 2002, 2009) and represent the highest precision radiometric ages for the most recent reversal. Here we show that paleointensity lows associated with excursional events can be comparable to or less than those associated with reversals. In addition, such field strength reductions can occur in time intervals as short as 3 thousand years.

  18. Large 14C excursion in 5480 BC indicates an abnormal sun in the mid-Holocene

    Science.gov (United States)

    Miyake, Fusa; Jull, A. J. Timothy; Panyushkina, Irina P.; Wacker, Lukas; Salzer, Matthew; Baisan, Christopher H.; Lange, Todd; Cruz, Richard; Masuda, Kimiaki; Nakamura, Toshio

    2017-01-01

    Radiocarbon content in tree rings can be an excellent proxy of the past incoming cosmic ray intensities to Earth. Although such past cosmic ray variations have been studied by measurements of 14C contents in tree rings with ≥10-y time resolution for the Holocene, there are few annual 14C data. There is a little understanding about annual 14C variations in the past, with the exception of a few periods including the AD 774‑775 14C excursion where annual measurements have been performed. Here, we report the result of 14C measurements using the bristlecone pine tree rings for the period from 5490 BC to 5411 BC with 1- to 2-y resolution, and a finding of an extraordinarily large 14C increase (20‰) from 5481 BC to 5471 BC (the 5480 BC event). The 14C increase rate of this event is much larger than that of the normal grand solar minima. We propose the possible causes of this event are an unknown phase of grand solar minimum, or a combination of successive solar proton events and a normal grand solar minimum.

  19. Chromospheric Rapid Blueshifted Excursions Observed with IBIS and Their Association with Photospheric Magnetic Field Evolution

    CERN Document Server

    Deng, Na; Liu, Chang; Jing, Ju; Tritschler, Alexandra; Reardon, Kevin P; Lamb, Derek A; Deforest, Craig E; Denker, Carsten; Wang, Shuo; Liu, Rui; Wang, Haimin

    2014-01-01

    Chromospheric rapid blueshifted excursions (RBEs) are suggested to be the disk counterparts of type II spicules at the limb and believed to contribute to the coronal heating process. Previous identification of RBEs was mainly based on feature detection using Dopplergrams. In this paper, we study RBEs on 2011 October 21 in a very quiet region at the disk center, which were observed with the high-cadence imaging spectroscopy of the Ca II 8542 A line from the Interferometric Bidimensional Spectrometer (IBIS). By using an automatic spectral analysis algorithm, a total of 98 RBEs are identified during a 11 minute period. Most of these RBEs have either a round or elongated shape, with an average area of 1.2 arcsec^2. The detailed temporal evolution of spectra from IBIS makes possible a quantitative determination of the velocity (~16 km/s) and acceleration (~400 m/s^2) of Ca II 8542 RBEs, and reveal an additional deceleration (~-160 m/s^2) phase that usually follows the initial acceleration. In addition, we also inv...

  20. On the Markovian assumption in the excursion set approach: The approximation of Markov Velocities

    CERN Document Server

    Musso, Marcello

    2014-01-01

    The excursion set approach uses the statistics of the density field, smoothed on a wide range of scales, to gain insight into a number of interesting processes in nonlinear structure formation, such as cluster assembly, merging and clustering. The approach treats the curve defined by the overdensity fluctuation field when changing the smoothing scale as a random walk. Most implementations of the approach then assume that, at least to a first approximation, the walks have uncorrelated steps, so that the walk heights are a Markov process. This assumption is known to be inaccurate: smoothing filters that are most easily related to the physics of structure formation generically yield walks whose steps are correlated with one another. We develop models in which it is the steps, rather than the walk heights, that are a Markov process. In such models, which we call Markov Velocity processes, each step correlates only with the previous one. We show that TopHat smoothing of a power law power spectrum with index n = -2...

  1. Gravitational Couplings for y-Gop-Planes

    CERN Document Server

    Ospina-Giraldo, J F

    2000-01-01

    The Wess-Zumino action for y deformed and generalized orientifold planes (yGOp-planes) is presented and one power expantion is realized from which processes that involves yGOp-planes, RR-forms, gravitons and gaugeons, are obtained. Finally non-standard yGOp-planes are showed.

  2. Linear Instability of the Plane Couette and Plane Poiseuille Flows

    CERN Document Server

    Chefranov, Sergey G

    2015-01-01

    We show possibility of the Plane Couette (PC) flow instability for Reynolds number Re>Reth=140. This new result of the linear hydrodynamic stability theory is obtained on the base of refusal from the traditionally used assumption on longitudinal periodicity of the disturbances along the direction of the fluid flow. We found that earlier existing understanding on the linear stability of this flow for any arbitrary large Reynolds number is directly related with an assumption on the separation of the variables of the spatial variability for the disturbance field and their periodicity in linear theory of stability. By the refusal from the pointed assumptions also for the Plane Poiseuille (PP) flow, we get a new threshold Reynolds value Reth=1040 that with 4% accuracy agrees with the experiment contrary to more than 500% discrepancy for the earlier known estimate Reth=5772 obtained in the frame of the linear theory but when using the "normal" disturbance form (S. A. Orszag, 1971).

  3. The Gothenburg geomagnetic excursion as a chronological marker for the Allerød interstadial in the Central Russian Upland

    Science.gov (United States)

    Gus'kova, E. G.; Raspopov, O. M.; Dergachev, V. A.; Iosifidi, A. G.; Sinitsyna, G. V.

    2012-12-01

    Palaeomagnetic investigations of deposits at the Baranova Gora archaeological site located near Volgo Lake (56.9°N, 33.2°E) in the Central Russian Upland have been carried out. The palaeomagnetic studies have revealed the development of the Gothenburg geomagnetic excursion dated at 13000-12350 BP. Revealing the Gothenburg excursion allowed us to use the findings of the palaeomagnetic investigations as a chronological benchmark, in addition to the results of palynological and archaeological (comparative analysis of archaeological artifacts) methods of dating the cultural layers of this archaeological monument, as well as to refine the time frame of the climatic Allerød interstadial in the Central Russian Upland. The data obtained in our study indicate that the Allerød interstadial in the Central Russian Upland began several hundred years before 12000 BP, the date commonly believed to be the beginning of the Allerød interstadial.

  4. The museum “La casa encantada” of Briones in the teaching of history: proposed primary education school excursion

    Directory of Open Access Journals (Sweden)

    Sebastián Molina Puche

    2013-05-01

    Full Text Available It has been demonstrated, in order that the school excursions develop all his didactic potential (this is, in order that they serve to stimulate the “guided discovery” learning, have to be framed in didactic itineraries and with it, to be considered as an integral part of the didactic programming of the course. The curricular integration of the school excursions is one of the principal problems which the teacher meets at the moment of putting in practical this important didactic resource. With this work we claim, beside showing many possibilities that there has the museum of “The Enchanted House” of Briones (section ethnology of the Museum of La Rioja for the learning of the history in Primary Education, to indicate how they can integrate in the curriculum the visits to the museum in each of three cycles that shape this educational level.

  5. Effects of Mitral Balloon Valvuloplasty on Left Ventricular Systolic Functions: Assessment with Color Tissue Doppler

    Directory of Open Access Journals (Sweden)

    Cevat Kırma

    2010-04-01

    Full Text Available Objective: Left ventricular (LV systolic functions are generally depressed in Mitral Stenosis (MS. Recovery of LV systolic functions demonstrated with 2D echocardiography in some patients by mitral balloon valvuloplasty (MBV. Systolic mitral annular velocity (S' by Tissue Doppler Imaging (TDI predicts LV systolic function. We aimed to evaluate early effects of MBV on LV systolic function by TDI.Methods: Forty-eight consecutive patients included to the study (39 female, 36±10 years. A full transthoracic echocardiographic study (TTE including left ventricular ejection fraction assessment by teicholz method and mitral annular color TDI assessment was performed 24 hours before and after MBV in all patients. MBV performed by Inoue technique under guidance of TTE. Analysis of mitral lateral annular S' wave velocity was performed immediately after echocardiographic examination. Results: MBV performed successfully in 43 patients (Group A, and severe mitral regurgitation developed in 5 patients(Group B. Mitral valve area, and S’ wave velocity increased, mean and maximum mitral gradient, and left atrial diameter, and systolic pulmonary artery pressure (PAP were reduced significantly by MBV in group A patients (p<0.01, =0.046, <0.01, <0.01, <0.01, <0.01, respectively. But, only mitral valve area increased significantly ingroup B patients (p<0.01. LVEF by teicholz did not change significantly in both groups. Conclusion: Improvements of LV systolic functions after successfull MBV can easily showed by color TDI where2D echocardiography could not indicate.

  6. Multiple High-Frequency Carbon Isotope Excursions Across the Precambrian-Cambrian Boundary: Implications for Correlations and Environmental Change

    Science.gov (United States)

    Smith, E. F.; Macdonald, F. A.; Schrag, D. P.; Laakso, T.

    2014-12-01

    The GSSP Precambrian-Cambrian boundary in Newfoundland is defined by the first appearance datum (FAD) of Treptichnus pedum, which is considered to be roughly coincident with the FAD of small shelly fossils (SSFs) and a large negative carbon isotope excursion. An association between the FAD of T. pedum and a negative carbon isotope excursion has previously been documented in Northwest Canada (Narbonne et al., 1994) and Death Valley (Corsetti and Hagadorn, 2000), and since then has been used as an chronostratigraphic marker of the boundary, particularly in siliciclastic poor sections that do not preserve T. pedum. Here we present new high-resolution carbon isotope (δ13C ) chemostratigraphy from multiple sections in western Mongolia and the western United States that span the Ediacaran-Cambrian transition. High-resolution sampling (0.2-1 m) reveals that instead of one large negative excursion, there are multiple, high-frequency negative excursions with an overall negative trend during the latest Ediacaran. These data help to more precisely calibrate changes in the carbon cycle across the boundary as well as to highlight the potential problem of identifying the boundary with just a few negative δ13C values. We then use a simple carbon isotope box model to explore relationships between phosphorous delivery to the ocean, oxygenation, alkalinity, and turnovers in carbonate secreting organisms. Corsetti, F.A., and Hagadorn, J.W., 2000, Precambrian-Cambrian transition: Death Valley, United States: Geology, v. 28, no. 4, p. 299-302. Narbonne, G.M., Kaufman, A.J., and Knoll, A.H., 1994, Integrated chemostratigraphy and biostratigraphy of the Windermere Supergroup, northwestern Canada: Implications for Neoproterozoic correlations and the early evolution of animals: Geological Society of America Bulletin, v. 106, no. 10, p. 1281-1292.

  7. French Geographers under International Gaze : regional excursions for the XIIIth International Geographical Congress, 1931 Les géographes français vus de l’étranger : excursions organisées à l’occasion du XIIIe Congrès International de Géographie en 1931

    Directory of Open Access Journals (Sweden)

    Hugh Clout

    2012-12-01

    Full Text Available Excursions accompanying international conferences provide important opportunities to transmit geographical knowledge. Fieldtrips associated with the International Geographical Congress in Paris are examined with respect to theme, leadership, and message. Leadership was entrusted to proven geographers holding doctorates, and to geologists working close to physical geography. Despite eight excursions being planned, opportunities were not offered to visit large sections of France. This pattern of activity reflected areas where regional monographs had been completed, and where annual inter-university excursions for French geographers had been run. Patronage by De Martonne (Sorbonne or by Blanchard (Grenoble was another important explanatory factor for who led excursions and where they took place.Les excursions offertes à l’occasion des congrès internationaux donnent des possibilités importantes pour la transmission des savoirs géographiques. Dans cet article on essaie d’analyser le contenu, la direction et les communications des excursions associées avec le Congrès International de Géographie à Paris. Malgré la préparation de huit excursions, de larges sections de l’Hexagone restaient fermées aux congressistes. Cette situation s’explique par la localisation et des études monographiques achevées, et des excursions interuniversitaires. Le patronage des grands maîtres (De Martonne à la Sorbonne, Blanchard à Grenoble fournit un autre élément d’explication.

  8. Excursion of the Sciatic Nerve During Nerve Mobilization Exercises: An In Vivo Cross-sectional Study Using Dynamic Ultrasound Imaging.

    Science.gov (United States)

    Coppieters, Michel W; Andersen, Line S; Johansen, Runar; Giskegjerde, Per K; Høivik, Mona; Vestre, Siv; Nee, Robert J

    2015-10-01

    Controlled laboratory cross-sectional study using single-group, within-subject comparisons. To determine whether different types of neurodynamic techniques result in differences in longitudinal sciatic nerve excursion. Large differences in nerve biomechanics have been demonstrated for different neurodynamic techniques for the upper limb (median nerve), but recent findings for the sciatic nerve have only revealed small differences in nerve excursion that may not be clinically meaningful. High-resolution ultrasound imaging was used to quantify longitudinal sciatic nerve movement in the thigh of 15 asymptomatic participants during 6 different mobilization techniques for the sciatic nerve involving the hip and knee. Healthy volunteers were selected to demonstrate normal nerve biomechanics and to eliminate potentially confounding variables associated with dysfunction. Repeated-measures analyses of variance were used to analyze the data. The techniques resulted in markedly different amounts of nerve movement (Pmovements. Consistent with current theories and findings for the median nerve, different neurodynamic exercises for the lower limb resulted in markedly different sciatic nerve excursions. Considering the continuity of the nervous system, the movement and position of adjacent joints have a large impact on nerve biomechanics.

  9. Shared Responsibility for Type 1 Diabetes Care Is Associated With Glycemic Variability and Risk of Glycemic Excursions in Youth.

    Science.gov (United States)

    Marker, Arwen M; Noser, Amy E; Clements, Mark A; Patton, Susana R

    2017-05-25

    We examined how parent and youth responsibility for type 1 diabetes (T1D) care is related to adherence and glycemic outcomes, namely, glycemic variability and risk of glycemic excursions. One hundred thirty-five parent-youth dyads (10-16 years old; diagnosed with T1D for at least 6 months) participated in this study. Percent responsibility of T1D care attributed to the youth, parent, or shared was measured using the Diabetes Family Responsibility Questionnaire. We collected youth's hemoglobin A1c (HbA1c) and glucometer downloads to examine relationships between responsibility and HbA1c, frequency of blood glucose monitoring (self-monitoring blood glucose, SMBG), risk of glycemic excursions, and actual glycemic variability using bivariate correlations and path analysis. Participants reported shared responsibility for almost half of T1D self-care tasks. Bivariate correlations showed shared responsibility was associated with less variability, whereas parent responsibility was associated with greater glycemic variability and risk for glycemic excursions. Youth responsibility was associated with lower frequency of SMBG. The path analyses confirmed our correlational findings ( p sresponsibility. Our results support the hypothesis that shared T1D responsibility is associated with better diabetes outcomes in youth.

  10. Congestive heart failure with preserved left ventricular systolic function after acute myocardial infarction

    DEFF Research Database (Denmark)

    Møller, Jacob Eifer; Brendorp, Bente; Ottesen, Michael

    2003-01-01

    AIMS: To characterise the prevalence, in-hospital complications, management, and long-term outcome of patients with congestive heart failure but preserved left ventricular systolic function after acute myocardial infarction. METHODS: 3166 consecutive patients screened for entry in the Bucindolol...... Evaluation in Acute Myocardial Infarction Trial with definite acute myocardial infarction and echocardiographic assessment of left ventricular systolic function were included between 1998 and 1999 in this prospective observational study. Main outcome measures were occurrences of in-hospital complications...... ventricular systolic function, and is associated with increased risk of in-hospital complications and death following acute myocardial infarction....

  11. [Development of an automatic pneumatic tourniquet system that determines pressures in synchrony with systolic blood pressure].

    Science.gov (United States)

    Liu, Hongyun; Li, Kaiyuan; Zhang, Zhengbo; Guo, Junyan; Wang, Weidong

    2012-11-01

    The correlation coefficients between arterial occlusion pressure and systolic blood pressure, diastolic blood pressure, limb circumference, body mass etc were obtained through healthy volunteer experiments, in which tourniquet were applied on upper/lower extremities. The prediction equations were derived from the data of experiments by multiple regression analysis. Based on the microprocessor C8051F340, a new pneumatic tourniquet system that can determine tourniquet pressure in synchrony with systolic blood pressure was developed and verified the function and stability of designed system. Results showed that the pneumatic tourniquet which automatically adjusts occlusion pressure in accordance with systolic blood pressure could stop the flow of blood to get a bloodless field.

  12. Impact of Baseline Systolic Blood Pressure and Long-Term Outcomes in Patients with Advanced Chronic Systolic Heart Failure (Insights from the BEST Trial)

    OpenAIRE

    2010-01-01

    The impact of baseline systolic blood pressure (SBP) on outcomes in advanced chronic systolic heart failure (HF) patients has not been studied using propensity-matched design. Of the 2706 Beta-Blocker Evaluation of Survival Trial (BEST) participants with chronic HF, New York Heart Association class III–IV symptoms and left ventricular ejection fraction ≤35%, 1751 had SBP ≤120 (median, 108; range, 70–120) mm Hg and 955 had SBP >120 (median, 134; range 121–192) mm Hg. Propensity scores for SBP ...

  13. On rank 5 projective planes

    Directory of Open Access Journals (Sweden)

    Otto Bachmann

    1984-01-01

    Full Text Available In this paper we continue the study of projective planes which admit collineation groups of low rank (Kallaher [1] and Bachmann [2,3]. A rank 5 collineation group of a projective plane ℙ of order n≠3 is proved to be flag-transitive. As in the rank 3 and rank 4 case this implies that is ℙ not desarguesian and that n is (a prime power of the form m4 if m is odd and n=m2 with m≡0mod4 if n is even. Our proof relies on the classification of all doubly transitive groups of finite degree (which follows from the classification of all finite simple groups.

  14. Hydrodynamics of planing monohull watercraft

    CERN Document Server

    Vorus, William S

    2017-01-01

    This book addresses the principles involved in the design and engineering of planing monohull power boats, with an emphasis on the theoretical fundamentals that readers need in order to be fully functional in marine design and engineering. Author William Vorus focuses on three topics: boat resistance, seaway response, and propulsion and explains the physical principles, mathematical details, and theoretical details that support physical understanding. In particular, he explains the approximations and simplifications in mathematics that lead to success in the applications of planing craft design engineering, and begins with the simplest configuration that embodies the basic physics. He leads readers, step-by-step, through the physical complications that occur, leading to a useful working knowledge of marine design and engineering. Included in the book are a wealth of examples that exemplify some of the most important naval architecture and marine engineering problems that challenge many of today’s engineers.

  15. Plane waves as tractor beams

    CERN Document Server

    Forgács, Péter; Romańczukiewicz, Tomasz

    2013-01-01

    It is shown that in a large class of systems plane waves can act as tractor beams: i.e., an incident plane wave can exert a pulling force on the scatterer. The underlying physical mechanism for the pulling force is due to the sufficiently strong scattering of the incoming wave into another mode having a larger wave number, in which case excess momentum is created behind the scatterer. Such a tractor beam or negative radiation pressure effect arises naturally in systems where the coupling between the scattering channels is due to Aharonov-Bohm (AB) gauge potentials. It is demonstrated that this effect is also present if the AB potential is an induced, ("artificial") gauge potential such as the one found in J. March-Russell, J. Preskill, F. Wilczek, Phys. Rev. Lett. 58 2567 (1992).

  16. Eight plane IPND mechanical testing.

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, A.; Guarino, V.; Wood, K.; Nephew, T.; Ayres, D.; Lee, A.; High Energy Physics; FNAL

    2008-03-18

    A mechanical test of an 8 plane IPND mechanical prototype, which was constructed using extrusions from the testing/tryout of the 16 cell prototype extrusion die in Argonne National Laboratory, was conducted. There were 4 vertical and 4 horizontal planes in this 8 plane IPND prototype. Each vertical plane had four 16 cell extrusions, while each horizontal plane had six 16 cell extrusions. Each plane was glued together using the formulation of Devcon adhesive, Devcon 60. The vertical extrusions used in the vertical planes shares the same dimensions as the horizontal extrusions in the horizontal planes with the average web thickness of 2.1 mm and the average wall thickness of 3.1 mm. This mechanical prototype was constructed with end-seals on the both ends of the vertical extrusions. The gaps were filled with epoxy between extrusions and end-seals. The overall dimension of IPND is 154.8 by 103.1 by 21.7 inches with the weight of approximately 1200 kg, as shown in a figure. Two similar mechanical tests of 3 layer and 11 layer prototypes have been done in order to evaluate the strength of the adhesive joint between extrusions in the NOvA detector. The test showed that the IPND prototype was able to sustain under the loading of weight of itself and scintillator. Two FEA models were built to verify the measurement data from the test. The prediction from FEA slice model seems correlated reasonably well to the test result, even under a 'rough' estimated condition for the wall thickness (from an untuned die) and an unknown property of 'garage type' extrusion. A full size of FEA 3-D model also agrees very well with the test data from strain gage readings. It is worthy to point out that the stress distribution of the structure is predominantly determined by the internal pressure, while the buckling stability relies more on the loading weight from the extrusions themselves and scintillate. Results of conducted internal pressure tests, including 3- cell, 11

  17. Force Lines in Plane Stress

    DEFF Research Database (Denmark)

    Rathkjen, Arne

    A state of plane stress is illustrated by means of two families of curves, each family representing constant values of a derivative of Airy's stress function. The two families of curves form a map giving in the first place an overall picture of regions of high and low stress, and in the second...... place, the map comprises a complete graphic representation of the stress at any point....

  18. Relationships between glucose excursion and the activation of oxidative stress in patients with newly diagnosed type 2 diabetes or impaired glucose regulation.

    Science.gov (United States)

    Zheng, Fenping; Lu, Weina; Jia, Chengfang; Li, Hong; Wang, Zhou; Jia, Weiping

    2010-02-01

    The effect of glucose excursions on oxidative stress is an important topic in diabetes research. We investigated this relationship by analyzing markers of oxidative stress and glycemic data from a continuous glucose monitoring system (CGMS) in 30 individuals with normal glucose regulation (NGR), 27 subjects with impaired glucose regulation (IGR), and 27 patients with newly diagnosed type 2 diabetes (T2DM). We compared the mean amplitude of glycemic excursion (MAGE), mean postprandial glucose excursion (MPPGE), and mean postprandial incremental area under the curve (IAUC) with plasma levels of oxidative stress markers 8-iso-PGF2α, 8-OH-dG, and protein carbonyl content in the study subjects. Patients with T2DM or IGR had significantly higher glucose excursions and plasma levels of oxidative stress markers compared to normal controls (P oxidative stress.

  19. CHROMOSPHERIC RAPID BLUESHIFTED EXCURSIONS OBSERVED WITH IBIS AND THEIR ASSOCIATION WITH PHOTOSPHERIC MAGNETIC FIELD EVOLUTION

    Energy Technology Data Exchange (ETDEWEB)

    Deng, Na; Chen, Xin; Liu, Chang; Jing, Ju; Wang, Shuo; Wang, Haimin [Space Weather Research Laboratory, New Jersey Institute of Technology, University Heights, Newark, NJ 07102-1982 (United States); Tritschler, Alexandra; Reardon, Kevin P. [National Solar Observatory, Sacramento Peak, Sunspot, NM 88349-0062 (United States); Lamb, Derek A.; Deforest, Craig E. [Southwest Research Institute, 1050 Walnut Street, Suite 300, Boulder, CO 80302-5142 (United States); Denker, Carsten [Leibniz-Institut für Astrophysik Potsdam, An der Sternwarte 16, D-14482 Potsdam (Germany); Liu, Rui, E-mail: na.deng@njit.edu [Department of Geophysics and Planetary Sciences, University of Science and Technology of China, Hefei 230026 (China)

    2015-02-01

    Chromospheric rapid blueshifted excursions (RBEs) are suggested to be the disk counterparts of type II spicules at the limb and believed to contribute to the coronal heating process. Previous identification of RBEs was mainly based on feature detection using Dopplergrams. In this paper, we study RBEs on 2011 October 21 in a very quiet region at the disk center, which were observed with the high-cadence imaging spectroscopy of the Ca II 8542 Å line from the Interferometric Bidimensional Spectrometer (IBIS). By using an automatic spectral analysis algorithm, a total of 98 RBEs are identified during an 11 minute period. Most of these RBEs have either a round or elongated shape, with an average area of 1.2 arcsec{sup 2}. The detailed temporal evolution of spectra from IBIS makes possible a quantitative determination of the velocity (∼16 km s{sup –1}) and acceleration (∼400 m s{sup –2}) of Ca II 8542 RBEs, and reveals an additional deceleration (∼–160 m s{sup –2}) phase that usually follows the initial acceleration. In addition, we also investigate the association of RBEs with the concomitant photospheric magnetic field evolution, using coordinated high-resolution and high-sensitivity magnetograms made by Hinode. Clear examples are found where RBEs appear to be associated with the preceding magnetic flux emergence and/or the subsequent flux cancellation. However, further analysis with the aid of the Southwest Automatic Magnetic Identification Suite does not yield a significant statistical association between these RBEs and magnetic field evolution. We discuss the implications of our results in the context of understanding the driving mechanism of RBEs.

  20. Environmental forcing of terrestrial carbon isotope excursion amplification across five Eocene hyperthermals

    Science.gov (United States)

    Bowen, G. J.; Abels, H.

    2015-12-01

    Abrupt changes in the isotope composition of exogenic carbon pools accompany many major episodes of global change in the geologic record. The global expression of this change in substrates that reflect multiple carbon pools provides important evidence that many events reflect persistent, global redistribution of carbon between reduced and oxidized stocks. As the diversity of records documenting any event grows, however, discrepancies in the expression of carbon isotope change among substrates are almost always revealed. These differences in magnitude, pace, and pattern of change can complicate interpretations of global carbon redistribution, but under ideal circumstances can also provide additional information on changes in specific environmental and biogeochemical systems that accompanied the global events. Here we evaluate possible environmental influences on new terrestrial records of the negative carbon isotope excursions (CIEs) associated with multiple hyperthermals of the Early Eocene, which show a common pattern of amplified carbon isotope change in terrestrial paleosol carbonate records relative to that recorded in marine substrates. Scaling relationships between climate and carbon-cycle proxies suggest that that the climatic (temperature) impact of each event scaled proportionally with the magnitude of its marine CIE, likely implying that all events involved release of reduced carbon with a similar isotopic composition. Amplification of the terrestrial CIEs, however, does not scale with event magnitude, being proportionally less for the first, largest event (the PETM). We conduct a sensitivity test of a coupled plant-soil carbon isotope model to identify conditions that could account for the observed CIE scaling. At least two possibilities consistent with independent lines of evidence emerge: first, varying effects of pCO2 change on photosynthetic carbon isotope discrimination under changing background pCO2, and second, contrasting changes in regional

  1. Secondary Structure Predictions for Long RNA Sequences Based on Inversion Excursions and MapReduce.

    Science.gov (United States)

    Yehdego, Daniel T; Zhang, Boyu; Kodimala, Vikram K R; Johnson, Kyle L; Taufer, Michela; Leung, Ming-Ying

    2013-05-01

    Secondary structures of ribonucleic acid (RNA) molecules play important roles in many biological processes including gene expression and regulation. Experimental observations and computing limitations suggest that we can approach the secondary structure prediction problem for long RNA sequences by segmenting them into shorter chunks, predicting the secondary structures of each chunk individually using existing prediction programs, and then assembling the results to give the structure of the original sequence. The selection of cutting points is a crucial component of the segmenting step. Noting that stem-loops and pseudoknots always contain an inversion, i.e., a stretch of nucleotides followed closely by its inverse complementary sequence, we developed two cutting methods for segmenting long RNA sequences based on inversion excursions: the centered and optimized method. Each step of searching for inversions, chunking, and predictions can be performed in parallel. In this paper we use a MapReduce framework, i.e., Hadoop, to extensively explore meaningful inversion stem lengths and gap sizes for the segmentation and identify correlations between chunking methods and prediction accuracy. We show that for a set of long RNA sequences in the RFAM database, whose secondary structures are known to contain pseudoknots, our approach predicts secondary structures more accurately than methods that do not segment the sequence, when the latter predictions are possible computationally. We also show that, as sequences exceed certain lengths, some programs cannot computationally predict pseudoknots while our chunking methods can. Overall, our predicted structures still retain the accuracy level of the original prediction programs when compared with known experimental secondary structure.

  2. A Model for the Decrease in Amplitude of Carbon Isotope Excursions Throughout the Phanerozoic

    Science.gov (United States)

    Bachan, A.; Lau, K. V.; Saltzman, M.; Thomas, E.; Kump, L. R.; Payne, J.

    2016-12-01

    The geological cycling of carbon ties the ocean-­atmosphere carbon pool to Earth's biosphere and sedimentary reservoirs. Perturbations to this coupled system are recorded in the carbon-isotopic (δ13C) composition of marine carbonates. Large amplitude δ13C variations with durations of 0.5 - 10 m.y. are typically treated as individual events and interpreted accordingly. However, a recent compilation of Phanerozoic data reveals a decline in the variance of the δ13C record over time, suggesting a common underlying control. Here we propose that the redox structure of the continental shelves was a key determinant of the sensitivity of the geologic carbon cycle: when oxygen minimum zones (OMZs) were large, shallow, and prone to expansion, recurrent physical forcings (such as sea level and tectonics) would have had the capacity to drive large changes in the areal extent of OMZs, resulting in a strong leverage on δ13C values. Using a simple model of the geologic carbon cycle, we demonstrate that interactions between the carbon and phosphate cycles can result in amplification of recurrent forcings with periods in the 0.5 - 10 m.y. range. Thus, rather than requiring that physical forcings have their largest amplitude of variation on those time scales, enhanced sensitivity of the carbon cycle can account for the characteristic duration of δ13C excursions. Biologically mediated aspects of geologic carbon cycling, including the depth of bioturbation and evolution of pelagic calcifiers, likely drove a decline in the depth and extent of ocean anoxia over the Phanerozoic resulting in the stabilization of the geologic carbon cycle.

  3. Effects of Fuscoporia obliqua on Postprandial Glucose Excursion and Endothelial Dysfunction in Type 2 Diabetic Patients

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Postprandial hyperglycemia has been reported to elicit endothelial dysfunction and provoke future cardiovascular complications. A reduction of postprandial blood glucose levels by the glucosidase inhibitor Fuscoporia obliqua was associated with a risk reduction of cardiovascular complications, but the effects of Fuscoporia obliqua on endothelial function have never been elucidated. This study is aimed to assess the efficacy of Fuscoporia obliqua on postprandial metabolic parameters and endothelial function in type 2 diabetic patients. Postprandial peak glucose (14.47±1.27 vs. 8.50±0.53 mmol/liter), plasma glucose excursion (PPGE), and change in the area under the curve (AUC) glucose after a single loading of test meal (total 450 kcal; protein 15.3%; fat 32.3%; carbohydrate 51.4%) were significantly higher in the diet-treated type 2 diabetic patients (n=14) than the age- and sex-matched controls (n=12). The peak forearm blood flow response and total reactive hyperemic flow (flow debt repayment) during reactive hyperemia, indices of resistance artery endothelial function on strain-gauge plethysmography, were unchanged before and after meal loading in the controls. But those of the diabetics were significantly decreased 120 and 240 min after the test meal. A prior administration of Fuscoporia obliqua decreased postprandial peak glucose, PPGE, and AUC glucose. The peak forearm blood flow and flow debt repayment were inversely well correlated with peak glucose, PPGE, and AUC glucose, but not with AUC insulin or the other lipid parameters. Even a single loading of the test meal was shown to impair the endothelial function in type 2 diabetic patients, and the postprandial endothelial dysfunction was improved by a prior use of Fuscoporia obliqua. Fuscoporia obliqua might reduce macrovascular complication by avoiding endothelial injury in postprandial hyperglycemic status.

  4. Excursions in Stable Carbon Isotopes at the End-Triassic Mass Extinction: Eastern North America and Morocco

    Science.gov (United States)

    Whiteside, J. H.; Et-Touhami, M.

    2012-04-01

    The end-Triassic mass extinction (ETE) at 201.4 million years ago is one of the five largest ecological disasters of the last 600 million years. Its cause is thought to be related to flood basalt eruptions of the Central Atlantic Magmatic Province (CAMP). In eastern North America, non-marine deposits recording this extinction occur below the oldest basalts (1), whereas in Morocco the extinction appears to be synchronous or possibly above the oldest basalt flow (2). In marine and paralic strata of Europe, the extinction is marked by a distinct negative carbon isotopic (δ13C) excursion (CIE) (3). This CIE is also apparent in organic carbon records from eastern North America (4,5). Here we present new δ13C data from organic carbon and terrestrial plant derived n-alkanes from the Central High Atlas and Argana basins [6] of Morocco). These data also suggest that the CIE is coincident with the ETE. In the Passaic Formation of the Newark basin, the negative excursion is associated with the palynofloral extinction level and a fern spore abundance anomaly (fern spike) (7). In the Silver Ridge core (B-2) from the Hartford basin (Connecticut), the negative excursion is also associated with an equisetalian spore spike. In the Fundy basin, at Partridge Island, Nova Scotia, the negative excursion occurs at the palynofloral extinction level, below the oldest basalts [here and (5)], and in Morocco it occurs just below the oldest basalts where Triassic pollen taxa are still present [here and 6)]. One interpretation is that the CIE is synchronous globally and reflects a major anomaly in the Earth's carbon cycle (e.g., 8). However, it is also possible that this pattern is a coincidence of artifactual enrichments of 12C in depositional and early diagenetic environments cut off from the exchangeable global reservoirs, such as in eastern North American lakes (4) and possibly in the canonical shallow marine sections from the UK. Distinguishing between these two classes of hypotheses is

  5. A Late Cambrian Carbon Isotope Excursion Recorded in Passive Margin Dolostones of the Central Appalachian Basin, USA.

    Science.gov (United States)

    Mackey, J. E.; Stewart, B. W.

    2016-12-01

    A Late Cambrian global positive carbon isotope excursion, known as the SPICE event [1,2] is linked to possible widespread ocean anoxia and enhanced carbon burial [3,4]. We report data from the central Appalachian Conasauga Group from the upper portion of the Middle Cambrian Maryville limestone, through the Late Cambrian Nolichucky shale and Maynardville limestone members. A geochemical, macro-, and micro-scale analyses of core material from southeastern Ohio was carried out to further constrain the timing of oceanic anoxia and trace element geochemistry relative to sediment fluxes occurring at the transition of the Middle to Late Cambrian. The section represents condensed, passive margin shale deposition and carbonate ramp development on the continental shelf of Laurentia. Carbonate sediments (primarily diagenetic dolomite) record a positive δ13C (relative to V-PDB) excursion starting in the upper Nolichucky shale member, reaching its peak (+4.0) in the overlying Maynardville limestone. At this location, there is an offset between the onlap Nolichucky shale deposition and start of the C isotope excursion; this was reported as well in a carbonate section further south of this location [2], on the other side of an extensional feature (Rome Trough) that formed a deep marine basin during Cambrian time. The condensed shale package and relatively low TOC content in our samples is likely due to the combination of a shallow, upslope basin location and isostatic influence on passive margin sedimentation. However, within the Rome Trough, the Nolichucky shale is rich in organic carbon and a recent target of hydrocarbon exploration. The data suggest a possible link between deposition of this shale and the global SPICE event. The robustness of the Late Cambrian δ13C excursion in diagenetically altered sediments and association with hydrocarbon bearing units indicates its utility as a stratigraphic indicator and as a target for exploration. Ongoing geochemical work will focus

  6. Long-term Paleomagnetic Secular Variation and Excursions from the western Equatorial Pacific Ocean (MIS2-4)

    Science.gov (United States)

    Lund, Steve; Schwartz, Martha; Stott, Lowell

    2017-01-01

    SUMMARYNew paleomagnetic results are presented for the Pleistocene (MIS2-4) portion of deep-sea core MD98-2181 (MD81; Devao Gulf, Philippine Islands). MD81 is the highest resolution (˜50 cm/ky) PSV record for ˜12-70 ka ever recovered from Equatorial latitudes (±15°). Magnetic studies indicate that MD81 has a stable natural remanence (NRM) with directional uncertainties (MAD angles) typically less than 3°. We have also recovered a relative paleointensity estimate from these sediments based on normalization to SIRMs. We have correlated our relative paleointensity record with high-resolution relative paleointensity records from the North Atlantic Ocean (Lund et al., 2001a, b). The MD81 ages are always within ± 500 years of the North Atlantic records over the entire core. We also correlate our PSV record with another published PSV record from Indonesia (MD34; Blanchet et al., 2006). We are able to correlate 25 inclination features, 25 declination features, and 24 relative paleointensity features between MD81 and MD34. We identify three intervals of `anomalous' directions in the cores (based on > 2σ deviation from mean directions). One of these intervals contains true excursional directions and is dated to ˜40.5 ka. We associate this interval with the Laschamp Excursion (e.g., Bonhommet and Zahringer, 1969; Lund et al, 2005). We also note two other intervals that have anomalous directions, but no true excursional directions. These intervals occur around ˜34.5 ka and ˜61.5 ka and we associate them with the Mono Lake Excursion (˜33.5-34.5 ka) in western USA (e.g., Liddicoat and Coe, 1979) and the Norwegian-Greenland Sea Excursion (˜61 ± 2 ka) in the North Atlantic Ocean (e.g., Nowaczyk et al., 1994). We view our `anomalous' PSV in the three intervals to be truly anomalous even though most directions are not truly excursional. We think that it is time to reconsider the definition of what is `anomalous' PSV or excursions. To do that we need good-quality PSV

  7. Inter arm systolic blood pressure difference is associated with a high prevalence of cardio vascular diseases

    Directory of Open Access Journals (Sweden)

    Narsingh Verma

    2016-04-01

    Results: The systolic blood pressure on right arm was 118.8+/-11.5 mmHg and 11.7+/-7.72 mmHg left arm. Result significantly showed higher mean systolic blood pressure on right arm. There were 54, 17 and 29 participants with inter-arm systolic blood pressure difference of 30. Out of 100 subjects, 11 subject having inter-arm systolic blood pressure difference and #8805;10 mmHg was associated with a family history of diabetes or hypertension. Conclusions: Presence of inter-arm blood pressure difference with having family history of hypertension or diabetes is more susceptible to develop cardiovascular disorder in future. [Int J Res Med Sci 2016; 4(4.000: 1177-1180

  8. Prognostic importance of systolic and diastolic function after acute myocardial infarction

    DEFF Research Database (Denmark)

    Møller, Jacob E; Egstrup, Kenneth; Køber, Lars

    2003-01-01

    BACKGROUND: Although risk stratification after acute myocardial infarction (AMI) often is focused on systolic left ventricular (LV) function, it appears that a more complete study of ventricular function including assessment of LV filling would be useful. Doppler echocardiography allows assessment...

  9. Diagnostic accuracy of 64 slice multidetector coronary computed tomographic angiography in left ventricular systolic dysfunction

    Directory of Open Access Journals (Sweden)

    Danny Lee

    2015-09-01

    Conclusion: Sixty-four slice multidetector CCTA is a very sensitive and fairly specific noninvasive diagnostic procedure for detecting coronary stenosis in patients with chest pain regardless of LV systolic function at presentation.

  10. Multidimensional Systolic Arrays of LMS AlgorithmAdaptive (FIR Digital Filters

    Directory of Open Access Journals (Sweden)

    Bakir A. R. Al-Hashemy

    2009-01-01

    Full Text Available A multidimensional systolic arrays realization of LMS algorithm by a method of mapping regular algorithm onto processor array, are designed. They are based on appropriately selected 1-D systolic array filter that depends on the inner product sum systolic implementation. Various arrays may be derived that exhibit a regular arrangement of the cells (processors and local interconnection pattern, which are important for VLSI implementation. It reduces latency time and increases the throughput rate in comparison to classical 1-D systolic arrays. The 3-D multilayered array consists of 2-D layers, which are connected with each other only by edges. Such arrays for LMS-based adaptive (FIR filter may be opposed the fundamental requirements of fast convergence rate in most adaptive filter applications.

  11. On-Treatment Blood Pressure and Cardiovascular Outcomes in Older Adults With Isolated Systolic Hypertension.

    Science.gov (United States)

    Yano, Yuichiro; Rakugi, Hiromi; Bakris, George L; Lloyd-Jones, Donald M; Oparil, Suzanne; Saruta, Takao; Shimada, Kazuyuki; Matsuoka, Hiroaki; Imai, Yutaka; Ogihara, Toshio

    2017-02-01

    Our aim was to assess optimal on-treatment blood pressure (BP) at which cardiovascular disease (CVD) and all-cause mortality risks are minimized in Japanese older adults with isolated systolic hypertension. We used data from the VALISH study (Valsartan in Elderly Isolated Systolic Hypertension) that recruited older adults (n=3035; mean age, 76 years) with systolic BP (SBP) of ≥160 mm Hg and diastolic BP of adults with isolated systolic hypertension, SBP in the range between 130 and 144 mm Hg was associated with minimal adverse outcomes and a reduction in CVD and all-cause mortality. The BP range will need to be confirmed in randomized controlled trials. URL: https://www.clinicaltrials.gov. Unique identifier: NCT00151229. © 2017 American Heart Association, Inc.

  12. Left atrial systolic force and outcome in asymptomatic mild to moderate aortic stenosis

    DEFF Research Database (Denmark)

    Cioffi, Giovanni; Cramariuc, Dana; Dalsgaard, Morten

    2012-01-01

    In patients with chronic pressure overload due to hypertension or aortic valve stenosis (AS), higher left atrial systolic force (LASF) is associated with a high-risk cardiovascular (CV) phenotype. We tested LASF as prognostic marker in patients with AS.......In patients with chronic pressure overload due to hypertension or aortic valve stenosis (AS), higher left atrial systolic force (LASF) is associated with a high-risk cardiovascular (CV) phenotype. We tested LASF as prognostic marker in patients with AS....

  13. Hemodynamic Correlates of Late Systolic Flow Velocity Augmentation in the Carotid Artery

    OpenAIRE

    Heffernan, Kevin S.; Lefferts, Wesley K; Augustine, Jacqueline A.

    2013-01-01

    Background. The contour of the common carotid artery (CCA) blood flow velocity waveform changes with age; CCA flow velocity increases during late systole, and this may contribute to cerebrovascular disease. Late systolic flow velocity augmentation can be quantified using the flow augmentation index (FAIx). We examined hemodynamic correlates of FAIx to gain insight into determinants of CCA flow patterns. Methods. CCA Doppler ultrasound and wave intensity analysis (WIA) were used to assess regi...

  14. Double product reflects the predictive power of systolic pressure in the general population

    DEFF Research Database (Denmark)

    Schutte, Rudolph; Thijs, Lutgarde; Asayama, Kei

    2013-01-01

    The double product (DP), consisting of the systolic blood pressure (SBP) multiplied by the pulse rate (PR), is an index of myocardial oxygen consumption, but its prognostic value in the general population remains unknown.......The double product (DP), consisting of the systolic blood pressure (SBP) multiplied by the pulse rate (PR), is an index of myocardial oxygen consumption, but its prognostic value in the general population remains unknown....

  15. Carbon isotopic record from Upper Devonian carbonates at Dongcun in Guilin, southern China, supporting the world-wide pattern of carbon isotope excursions during Frasnian-Famennian transition

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Two positive δ13C excursions are presented in records from the Frasnian-Famennian (F-F) marine carbonate sediments in Europe, America, Africa, and Australia, having been considered as a worldwide pattern, and attributed to enhanced organic carbon burial during the F-F biological mass extinction. However, this worldwide pattern has not been revealed from the well-deposited Late Devonian sequences in southern China. In this paper, a detailed investigation has been made on the Late Devonian section at Dongcun, Guilin, southern China to constrain perturbations in δ13C of carbonates in the F-F deposited sequence. The result from this section also indicates two positive δ13C excursions during the F-F transition. The first excursion with an amplitude of 1.5‰ occurred at the bottom of linguiformis Zone, later than the early excursion existing in the Late rhenana Zone of the Late Devonian profiles in other continents, especially, in central Europe. This difference has been expected to be a result as conodont Palmatolepis linguiformis occurred earlier in southern China than other sites. The second excursion with an amplitude of 2.1‰ is located at the F-F boundary, same as the records from other continents. This result strongly supports the view that two carbon isotope positive excursions during the F-F transition are common in carbonate sediments, resulting from worldwide increases of organic carbon burial intensity.

  16. Systolic mitral annulus velocity is a sensitive index for changes in left ventricular systolic function during inotropic therapy in patients with acute heart failure.

    Science.gov (United States)

    Husebye, Trygve; Eritsland, Jan; Bjørnerheim, Reidar; Andersen, Geir Ø

    2017-01-01

    Echocardiography is recommended for assessment of left ventricular systolic function in patients with acute heart failure but few randomised trials have validated techniques like tissue Doppler (TDI) and speckle tracking (STE) in patients with acute heart failure following ST-elevation myocardial infarction. This was a substudy from the LEAF (LEvosimendan in Acute heart Failure following myocardial infarction) trial (NCT00324766 ), which randomised 61 patients developing acute heart failure, including cardiogenic shock, within 48 hours after ST-elevation myocardial infarction, double-blind to a 25-hour infusion of levosimendan or placebo. TDI-derived systolic mitral annulus velocity (S'), STE-derived global longitudinal strain (Sl) and strain rate (SRl) were measured at baseline, day 1, day 5 and after 42 days. Datasets rejected for analyses were 2% (TDI) and 17% (STE). S' increased by 23% in the levosimendan group versus 8% in the placebo group from baseline to day 1 ( p= 0.011) and by 30% vs. 3% from baseline to day 5 ( p sensitive indices for changes in left ventricular systolic function related to treatment with levosimendan. However, S' by TDI was more feasible and sensitive and might be preferred for assessment of changes in left ventricular systolic function in critically ill patients with acute heart failure receiving inotropic therapy.

  17. Transversus abdominis plane block for an emergency laparotomy in a high-risk, elderly patient

    Directory of Open Access Journals (Sweden)

    Surekha S Patil

    2010-01-01

    Full Text Available A 72-year-old male patient with gall bladder perforation and small intestinal obstruction from impacted gall stone was posted for emergency laparotomy. He had congestive heart failure, severe hypertension at admission and history of multiple other coexisting diseases. On admission, he developed pulmonary oedema from systolic hypertension which was controlled by ventilatory support, nitroglycerine and furosemide. Preoperative international normalized ratio was 2.34 and left ventricular ejection fraction was only 20%. Because of risk of exaggerated fall in blood pressure during induction of anaesthesia (general or neuraxial, a transversus abdominis plane block via combined Petit triangle and subcostal technique was administered and supplemented with Propofol sedation.

  18. SNAP Satellite Focal Plane Development

    Energy Technology Data Exchange (ETDEWEB)

    Bebek, C.; Akerlof, C.; Aldering, G.; Amanullah, R.; Astier, P.; Baltay, C.; Barrelet, E.; Basa, S.; Bercovitz, J.; Bergstrom, L.; Berstein, G.P.; Bester, M.; Bohlin, R.; Bonissent, A.; Bower, C.; Campbell, M.; Carithers, W.; Commins, E.; Day, C.; Deustua, S.; DiGennaro, R.; Ealet, A.; Ellis, R.; Emmett, W.; Eriksson, M.; Fouchez,D.; Fruchter, A.; Genat, J-F.; Goldhaber, G.; Goobar, A.; Groom, D.; Heetderks, H.; Holland, S.; Huterer, D.; Johnson, W.; Kadel, R.; Karcher,A.; Kim, A.; Kolbe, W.; Lafever, R.; Lamoureaux, J.; Lampton, M.; Lefevre, O.; Levi, M.; Levin, D.; Linder, E.; Loken, S.; Malina, R.; Mazure, A.; McKay, T.; McKee, S.; Miquel, R.; Morgan, N.; Mortsell, E.; Mostek, N.; Mufson, S.; Musser, J.; Roe, N.; Nugent, P.; Oluseyi, H.; Pain, R.; Palaio, N.; Pankow, D.; Perlmutter, S.; Prieto, E.; Rabinowitz,D.; Refregier, A.; Rhodes, J.; Schubnell, M.; Sholl, M.; Smadja, G.; Smith, R.; Smoot, G.; Snyder, J.; Spadafora, A.; Szymkowiak, A.; Tarle,G.; Taylor, K.; Tilquin, A.; Tomasch, A.; Vincent, D.; von der Lippe, H.; Walder, J-P.; Wang, G.

    2003-07-07

    The proposed SuperNova/Acceleration Probe (SNAP) mission will have a two-meter class telescope delivering diffraction-limited images to an instrumented 0.7 square degree field in the visible and near-infrared wavelength regime. The requirements for the instrument suite and the present configuration of the focal plane concept are presented. A two year R&D phase, largely supported by the Department of Energy, is just beginning. We describe the development activities that are taking place to advance our preparedness for mission proposal in the areas of detectors and electronics.

  19. Effect of Visit-to-Visit Variation of Heart Rate and Systolic Blood Pressure on Outcomes in Chronic Systolic Heart Failure: Results From the Systolic Heart Failure Treatment With the If Inhibitor Ivabradine Trial (SHIFT) Trial.

    Science.gov (United States)

    Böhm, Michael; Robertson, Michele; Borer, Jeffrey; Ford, Ian; Komajda, Michel; Mahfoud, Felix; Ewen, Sebastian; Swedberg, Karl; Tavazzi, Luigi

    2016-02-12

    Elevated resting heart rate (HR) and low systolic blood pressure (SBP) are related to poor outcomes in heart failure (HF). The association between visit-to-visit variation in SBP and HR and risk in HF is unknown. In Systolic Heart Failure Treatment with the If inhibitor ivabradine Trial (SHIFT) patients, we evaluated relationships between mean HR, mean SBP, and visit-to-visit variations (coefficient of variation [CV]=SD/mean×100%) in SBP and HR (SBP-CV and HR-CV, respectively) and primary composite endpoint (cardiovascular mortality or HF hospitalization), its components, all-cause mortality, and all-cause hospitalization. High HR and low SBP were closely associated with risk for primary endpoint, all-cause mortality, and HF hospitalization. The highest number of primary endpoint events occurred in the highest HR tertile (38.8% vs 16.4% lowest tertile; PHeart Association, Inc., by Wiley Blackwell.

  20. On free fermions and plane partitions

    CERN Document Server

    Foda, O; Zuparic, M

    2008-01-01

    We use free fermion methods to re-derive a result of Okounkov and Reshetikhin relating charged fermions to random plane partitions, and to extend it to relate neutral fermions to strict plane partitions.

  1. Paleoclimate variability during the Blake geomagnetic excursion (MIS 5d) deduced from a speleothem record

    Science.gov (United States)

    Rossi, Carlos; Mertz-Kraus, Regina; Osete, María-Luisa

    2014-10-01

    To evaluate possible connections between climate and the Earth's magnetic field, we examine paleoclimate proxies in a stalagmite (PA-8) recording the Blake excursion (˜112-˜116.4 ka) from Cobre cave (N Spain). Trace element, δ13C, δ18O, δ234U, fluorescent lamination, growth rate, and paleomagnetic records were synchronized using a floating lamina-counted chronology constrained by U-Th dates, providing a high-resolution multi-proxy paleoclimate record for MIS 5d. The alpine cave setting and the combination of proxies contributed to improve the confidence of the paleoclimatic interpretation. Periods of relatively warm and humid climate likely favored forest development and resulted in high speleothem growth rates, arguably annual fluorescent laminae, low δ13C and [Mg], and increased [Sr] and [Ba]. Colder periods limited soil activity and drip water availability, leading to reduced speleothem growth, poor development of fluorescent lamination, enhanced water-rock interaction leading to increased [Mg], δ13C, and δ234U, and episodic flooding. In the coldest and driest period recorded, evaporation caused simultaneous 18O and 13C enrichments and perturbed the trace element patterns. The Blake took place in a relatively warm interestadial at the inception of the Last Glacial period, but during a global cooling trend recorded in PA-8 by an overall decrease of δ18O and growth rate and increasing [Mg]. That trend culminated in the cessation of growth between ˜112 and ˜101 ka likely due to the onset of local glaciation correlated with Greenland stadial 25. That trend is consistent with a link between low geomagnetic intensity and climate cooling, but it does not prove it. Shorter term changes in relative paleointensity (RPI) relate to climate changes recorded in PA-8, particularly a prominent RPI low from ˜114.5 to ˜113 ka coincident with a significant cooling indicated by all proxy records, suggesting a link between geomagnetic intensity and climate at millennial

  2. Boron Isotopic Composition Variation During Early-Bajocian δ13Cmin Positive Excursion

    Science.gov (United States)

    Paris, G.; Gaillardet, J.; Bartolini, A.; Donnadieu, Y.; Beaumont, V.

    2008-12-01

    Early Bajocian is a period of sea level rise and platform drowning during the mid-Jurassic greenhouse world. This period is geochemically characterized by a positive excursion of inorganic δ13C signal as recorded in Western Thetys sections. This signal, concomitant with an increased biosiliceous sedimentation, is meant to reflect both a eutrophication event and a carbonate production crisis (Bartolini et al. 1996 ; Bartolini and Cecca 1999). High atmospheric CO2 level is assumed for this period, linked with the birth of the Pacific Plate and a faster sea-floor spreading (Bartolini and Larson 2001). Opening of the Liguro- Piemontese ocean may have led to rearrangement of oceanic current circulation patterns. These global conditions, potentially leading to oceanic eutrophication and carbonate saturation state modification, have been suggested as a trigger for Early-Bajocian events. Atmospheric CO2, carbon cycle and seawater pH are connected through the seawater carbonate system and boron isotopes in carbonates are a paleopH proxy. Geochemical analyses including δ11B were performed on bajocian carbonates from Terminilletto section, Italy, one of the rare carbonate section spanning this period. A new extraction process combined with a new direct injection method for MC-ICP-MS (d-DIHEN) helped to improve analyses reproducibilty (Louvat et al. in prep). The results show clearly a variation of the isotopic signal. This variation can be explained by a rise of seawater pH, occuring just before the carbonate production crisis and connected to the eutrophication. Modelisation will thus be performed to reproduce pH variation and reconstitute carbon cycle perturbation at this time. Bartolini A., Baumgartner P. O., and Hunziker J. (1996) Middle and Late Jurassic carbon stable-isotope stratigraphy and radiolarite sedimentation of the Umbria- Marche Basin (Central Italy). Eclogae geol. Helv. 89(2), 811-844. Bartolini A. and Cecca F. (1999) 20 My hiatus in the Jurassic of Umbria

  3. Carbon isotope excursions in paleosol carbonate marking five early Eocene hyperthermals in the Bighorn Basin, Wyoming

    Directory of Open Access Journals (Sweden)

    H. A. Abels

    2015-05-01

    Full Text Available Transient greenhouse warming events in the Paleocene and Eocene were associated with the addition of isotopically-light carbon to the exogenic atmosphere–ocean carbon pool, leading to substantial environmental and biotic change. The magnitude of an accompanying carbon isotope excursion (CIE can be used to constrain both the sources and amounts of carbon released during an event, as well as to correlate marine and terrestrial records with high precision. The Paleocene Eocene Thermal Maximum (PETM is well documented, but CIE records for the subsequent warming events are still rare especially from the terrestrial realm. Here, we provide new CIE records for two of the smaller hyperthermal events, I1 and I2, in paleosol carbonate, as well as two additional records of ETM2 and H2 in the Bighorn Basin. Stratigraphic comparison of this expanded, high-resolution terrestrial carbon isotope record to the deep-sea benthic foraminifera records from ODP Sites 1262 and 1263, Walvis Ridge, in the southern Atlantic Ocean corroborates that the Bighorn Basin fluvial sediments record global atmospheric change. The stratigraphic thicknesses of the eccentricity-driven hyperthermals in these archives are in line with precession-forcing of the 7 m thick fluvial overbank-avulsion sedimentary cycles. Using the CALMAG bulk oxide mean annual precipitation proxy, we reconstruct similar or slightly wetter than background soil moisture contents during the four younger hyperthermals, in contrast to drying observed during the PETM. Soil carbonate CIEs vary in magnitude proportionally with the marine CIEs for the four smaller early Eocene hyperthermals. This relationship breaks down for the PETM, with the soil carbonate CIE ~ 2–4‰ less than expected if all five linearly relate to marine CIEs. If the PETM CO2 forcing was similar but scaled to the younger hyperthermals, photosynthetic isotope fractionation or soil environmental factors are needed to explain this anomaly. We

  4. Cinnamon extract inhibits α-glucosidase activity and dampens postprandial glucose excursion in diabetic rats

    Directory of Open Access Journals (Sweden)

    Thirumurugan Kavitha

    2011-06-01

    Full Text Available Abstract Background α-glucosidase inhibitors regulate postprandial hyperglycemia (PPHG by impeding the rate of carbohydrate digestion in the small intestine and thereby hampering the diet associated acute glucose excursion. PPHG is a major risk factor for diabetic vascular complications leading to disabilities and mortality in diabetics. Cinnamomum zeylanicum, a spice, has been used in traditional medicine for treating diabetes. In this study we have evaluated the α-glucosidase inhibitory potential of cinnamon extract to control postprandial blood glucose level in maltose, sucrose loaded STZ induced diabetic rats. Methods The methanol extract of cinnamon bark was prepared by Soxhlet extraction. Phytochemical analysis was performed to find the major class of compounds present in the extract. The inhibitory effect of cinnamon extract on yeast α-glucosidase and rat-intestinal α-glucosidase was determined in vitro and the kinetics of enzyme inhibition was studied. Dialysis experiment was performed to find the nature of the inhibition. Normal male Albino wistar rats and STZ induced diabetic rats were treated with cinnamon extract to find the effect of cinnamon on postprandial hyperglycemia after carbohydrate loading. Results Phytochemical analysis of the methanol extract displayed the presence of tannins, flavonoids, glycosides, terpenoids, coumarins and anthraquinones. In vitro studies had indicated dose-dependent inhibitory activity of cinnamon extract against yeast α-glucosidase with the IC 50 value of 5.83 μg/ml and mammalian α-glucosidase with IC 50 value of 670 μg/ml. Enzyme kinetics data fit to LB plot pointed out competitive mode of inhibition and the membrane dialysis experiment revealed reversible nature of inhibition. In vivo animal experiments are indicative of ameliorated postprandial hyperglycemia as the oral intake of the cinnamon extract (300 mg/kg body wt. significantly dampened the postprandial hyperglycemia by 78.2% and 52

  5. GeoLab in NASA's Pressurized Excursion Module: First Results from the 2010 Field Trials

    Science.gov (United States)

    Evans, Cynthia A.; Calaway, Michael; Bell, Mary Sue; Graff, Trevor

    2010-01-01

    Before humans explore other planets, NASA must develop advanced techniques for collection, preservation and return of unique extraterrestrial samples. To help evaluate hardware requirements and operational concepts for future sample-return missions, we designed and built GeoLab our first generation lab for geological samples into NASA s Habitat Demonstration Unit in the Pressurized Excursion Module (HDU1-PEM). The center of GeoLab is a glovebox for the examination of samples in a shirt-sleeve environment. As part of a deployable habitat, GeoLab can participate in NASA s analog missions that simulate planetary exploration activities and support the testing of relevant technologies for collecting and handling geological samples. Over time, these tests will evaluate sample handling environments (field and lab), sampling tools and analytical instruments, and different scenarios involving both robotic and human procedures. The GeoLab design supports evolving tests and configurations. The glovebox is mounted on the habitat bulkhead, with three sample pass-though chambers that allow for direct sample transfer into the glovebox from the outside. The glovebox design and construction (low-particle shedding, minimally off-gassing materials) provides a clean environment to reduce sample contamination; in the future, we will integrate a positive pressure, enriched nitrogen atmosphere. The glovebox is equipped with configurable instrument ports. The 2010 test included a mass balance, a stereomicroscope with a HD camera for detailed imaging of samples, and a handheld XRF analyzer for preliminary geochemical characterization of samples. Network cameras provided context imagery and sample handling activities. We present early results from the initial field trial of GeoLab during the 2010 Desert Research and Technology Studies (D-RATS) planetary analog test near Flagstaff AZ. The 2010 D-RATS mission involved two rovers, the habitat with GeoLab, four crew members, and a team of

  6. Image plane sweep volume illumination.

    Science.gov (United States)

    Sundén, Erik; Ynnerman, Anders; Ropinski, Timo

    2011-12-01

    In recent years, many volumetric illumination models have been proposed, which have the potential to simulate advanced lighting effects and thus support improved image comprehension. Although volume ray-casting is widely accepted as the volume rendering technique which achieves the highest image quality, so far no volumetric illumination algorithm has been designed to be directly incorporated into the ray-casting process. In this paper we propose image plane sweep volume illumination (IPSVI), which allows the integration of advanced illumination effects into a GPU-based volume ray-caster by exploiting the plane sweep paradigm. Thus, we are able to reduce the problem complexity and achieve interactive frame rates, while supporting scattering as well as shadowing. Since all illumination computations are performed directly within a single rendering pass, IPSVI does not require any preprocessing nor does it need to store intermediate results within an illumination volume. It therefore has a significantly lower memory footprint than other techniques. This makes IPSVI directly applicable to large data sets. Furthermore, the integration into a GPU-based ray-caster allows for high image quality as well as improved rendering performance by exploiting early ray termination. This paper discusses the theory behind IPSVI, describes its implementation, demonstrates its visual results and provides performance measurements.

  7. The INTEGRAL Galactic Plane Scanning

    CERN Document Server

    Fiocchi, Mariateresa

    2013-01-01

    After the first nine years of INTEGRAL operational life, the discovery of new sources and source types, a large fraction of which are highly transient or highly absorbed, is certainly one of the most compelling results and legacies of INTEGRAL. Frequent monitoring of the Galactic Plane in AO8 and AO9 campaigns allowed us to detect transient sources, both known and new, confirming that the gamma-ray sky is dominated by the extreme variability of different classes of objects. Regular scans of the Galactic Plane by INTEGRAL provide the most sensitive hard X-ray wide survey to date of our Galaxy, with flux limits of the order of 0.3 mCrab for an exposure time of ~2Ms. Many transient sources have been detected on a wide range of time scales (~hours to months) and identified by triggered followup observations, mainly by Swift/XRT and optical/infrared telescopes. These discoveries are very important to characterize the X-ray binary population in our Galaxy, that is necessary input for evolution studies. The transien...

  8. The HAWC Galactic Plane Survey

    Science.gov (United States)

    Hui, Michelle

    2016-03-01

    The High Altitude Water Cherenkov (HAWC) Observatory is an all-sky surveying instrument that covers 2/3 of the sky in 24 hours. It is designed with an emphasis on continuous sky coverage for transient events, and on the measurement of extended and large-scale structures. The array is located in Sierra Negra, Mexico at an elevation of 4,100 m and was inaugurated in March 2015. The HAWC array consists of 300 water Cherenkov detectors and is sensitive to extensive air showers triggered by cosmic rays and gamma rays from 100 GeV to >100 TeV. Thanks to its modular design, data taking began in Summer 2013 with 1/3 of the array. Analysis of the first year of data with the partial array shows detections that are coincident with known TeV supernova remnants and pulsar wind nebulae along the Galactic plane. Spectral and morphological analyses are ongoing to study the particle population and acceleration mechanism of these objects. With a growing data set taken with the completed array, source searches are underway for both point-like and extended emission along the Galactic plane, which contain many objects such as pulsar wind nebulae, young star clusters, and binaries.

  9. Lines, Circles, Planes and Spheres

    CERN Document Server

    Purdy, George B

    2009-01-01

    Let $S$ be a set of $n$ points in $\\mathbb{R}^3$, no three collinear and not all coplanar. If at most $n-k$ are coplanar and $n$ is sufficiently large, the total number of planes determined is at least $1 + k \\binom{n-k}{2}-\\binom{k}{2}(\\frac{n-k}{2})$. For similar conditions and sufficiently large $n$, (inspired by the work of P. D. T. A. Elliott in \\cite{Ell67}) we also show that the number of spheres determined by $n$ points is at least $1+\\binom{n-1}{3}-t_3^{orchard}(n-1)$, and this bound is best possible under its hypothesis. (By $t_3^{orchard}(n)$, we are denoting the maximum number of three-point lines attainable by a configuration of $n$ points, no four collinear, in the plane, i.e., the classic Orchard Problem.) New lower bounds are also given for both lines and circles.

  10. Singularities from colliding plane gravitational waves

    Science.gov (United States)

    Tipler, Frank J.

    1980-12-01

    A simple geometrical argument is given which shows that a collision between two plane gravitational waves must result in singularities. The argument suggests that these singularities are a peculiar feature of plane waves, because singularities are also a consequence of a collision between self-gravitating plane waves of other fields with arbitrarily small energy density.

  11. Singularities from colliding plane gravitational waves

    Energy Technology Data Exchange (ETDEWEB)

    Tipler, F.J.

    1980-12-15

    A simple geometrical argument is given which shows that a collision between two plane gravitational waves must result in singularities. The argument suggests that these singularities are a peculiar feature of plane waves, because singularities are also a consequence of a collision between self-gravitating plane waves of other fields with arbitrarily small energy density.

  12. Evolved stars in galactic plane surveys

    NARCIS (Netherlands)

    Verbeek, K.

    2013-01-01

    For the first time in history the entire Galactic Plane is digitally mapped from La Palma and Chile by the European Galactic Plane surveys EGAPS (UVEX, IPHAS and VPHAS+, see http://www.uvexsurvey.org http://www.iphas.org and http://www.vphasplus.org). The complete Galactic plane (3600 square degrees

  13. Homogeneity and plane-wave limits

    CERN Document Server

    Figueroa-O'Farrill, J M; Philip, S; Farrill, Jos\\'e Figueroa-O'; Meessen, Patrick; Philip, Simon

    2005-01-01

    We explore the plane-wave limit of homogeneous spacetimes. For plane-wave limits along homogeneous geodesics the limit is known to be homogeneous and we exhibit the limiting metric in terms of Lie algebraic data. This simplifies many calculations and we illustrate this with several examples. We also investigate the behaviour of (reductive) homogeneous structures under the plane-wave limit.

  14. Fractionation between inorganic and organic carbon during the Lomagundi (2.22 2.1 Ga) carbon isotope excursion

    Science.gov (United States)

    Bekker, A.; Holmden, C.; Beukes, N. J.; Kenig, F.; Eglinton, B.; Patterson, W. P.

    2008-07-01

    The Lomagundi (2.22-2.1 Ga) positive carbon isotope excursion in shallow-marine sedimentary carbonates has been associated with the rise in atmospheric oxygen, but subsequent studies have demonstrated that the carbon isotope excursion was preceded by the rise in atmospheric oxygen. The amount of oxygen released to the exosphere during the Lomagundi excursion is constrained by the average global fractionation between inorganic and organic carbon, which is poorly characterized. Because dissolved inorganic and organic carbon reservoirs were arguably larger in the Paleoproterozoic ocean, at a time of lower solar luminosity and lower ocean redox state, decoupling between these two variables might be expected. We determined carbon isotope values of carbonate and organic matter in carbonates and shales of the Silverton Formation, South Africa and in the correlative Sengoma Argillite Formation, near the border in Botswana. These units were deposited between 2.22 and 2.06 Ga along the margin of the Kaapvaal Craton in an open-marine deltaic setting and experienced lower greenschist facies metamorphism. The prodelta to offshore marine shales are overlain by a subtidal carbonate sequence. Carbonates exhibit elevated 13C values ranging from 8.3 to 11.2‰ vs. VPDB consistent with deposition during the Lomagundi positive excursion. The total organic carbon (TOC) contents range from 0.01 to 0.6% and δ13C values range from - 24.8 to - 13.9‰. Thus, the isotopic fractionation between organic and carbonate carbon was on average 30.3 ± 2.8‰ ( n = 32) in the shallow-marine environment. The underlying Sengoma shales have highly variable TOC contents (0.14 to 21.94%) and δ13C values (- 33.7 to - 20.8‰) with an average of - 27.0 ± 3.0‰ ( n = 50). Considering that the shales were also deposited during the Lomagundi excursion, and taking δ13C values of the overlying carbonates as representative of the δ13C value of dissolved inorganic carbon during shale deposition, a carbon

  15. Using extra systoles to predict fluid responsiveness in cardiothoracic critical care patients.

    Science.gov (United States)

    Vistisen, Simon Tilma

    2017-08-01

    Fluid responsiveness prediction is an unsettled matter for most critical care patients and new methods relying only on the continuous basic monitoring are desired. It was hypothesized that the post-ectopic beat, which is associated with increased preload, could be analyzed in relation to preceding sinus beats and that the change in cardiac performance (e.g. systolic blood pressure) at the post-ectopic beat could predict fluid responsiveness. Cardiothoracic critical care patients scheduled for a 500 ml volume expansion were observed. In the 30 min prior to volume expansion, the ECG was analyzed for occurrence of extra systoles preceded by at least 10 sinus beats. Classification variables, were defined as the change in a variable (e.g. systolic blood pressure or pre-ejection period) from the median of 10 preceding sinus beats to extra systolic post-ectopic beat. A stroke volume increase >15 % following volume expansion defined fluid responsiveness. Thirty patients were included. The change in systolic blood pressure predicted fluid responsiveness in 24 patients correctly with 83 % specificity and 75 % sensitivity (optimal threshold: 5 % systolic blood pressure increase), receiver operating characteristic (ROC) area: 0.81 (CI [0.64;0.98]). The change in pre-ejection period predicted fluid responsiveness in 22 patients correctly with 67 % specificity and 83 % sensitivity (optimal threshold: 19 ms pre-ejection period decrease), ROC area: 0.81 (CI [0.66;0.96]). Pulse pressure variation had ROC area of 0.57 (CI [0.39;0.75]). Based on standard critical care monitoring, analysis of the extra systolic post-ectopic beat predicts fluid responsiveness in cardiothoracic critical care patients with good accuracy.

  16. Marine Carbon-Sulfur Biogeochemical Cycles during the Steptoean Positive Carbon Isotope Excursion (SPICE) in the Jiangnan Basin, South China

    Institute of Scientific and Technical Information of China (English)

    Yang Peng; Yongbo Peng; Xianguo Lang; Haoran Ma; Kangjun Huang; Fangbing Li; Bing Shen

    2016-01-01

    ABSTRACT:Global occurrences of Steptoean Positive Carbon Isotope Excursion (SPICE) during Late Cambrian recorded a significant perturbation in marine carbon cycle, and might have had profound impacts on the biological evolution. In previous studies, SPICE has been reported from the Jiangnan slope belt in South China. To evaluate the bathymetric extent of SPICE, we investigate the limestone samples from the upper Qingxi Formation in the Shaijiang Section in the Jiangnan Basin. Our results show the positive excursions for both carbonate carbon (δ13C) and organic carbon (δ13Corg) isotopes, as well as the concurrent positive shifts in sulfur isotopes of carbonate associated sulfate (CAS, δ34SCAS) and pyrite (δ34Spyrite), unequivocally indicating the presence of SPICE in the Jiangnan Basin. A 4‰increase inδ13Ccarb of the Qingxi limestone implies the increase of the relative flux of organic carbon burial by a factor of two. Concurrent positive excursions inδ34SCAS andδ34Spyrite have been attributed to the enhanced pyrite burial in oceans with extremely low concentration and spatially heterogeneous isotopic composition of seawater sulfate. Here, we propose that the seawater sulfur isotopic heterogeneity can be generated by volatile organic sulfur compound (VOSC, such as methanethiol and dimethyl sulfide) formation in sulfidic continental margins that were widespread during SPICE. Emission of 32S-enriched VOSC in atmosphere, followed by lateral transportation and aerobic oxidation in atmosphere, and precipitation in open oceans result in a net flux of 32S from continental margins to open oceans, elevatingδ34S of seawater sulfate in continental margins. A simple box model indicates that about 35%to 75%of seawater sulfate in continental margins needs to be transported to open oceans via VOSC formation.

  17. Isokinetic eccentric exercise can induce skeletal muscle injury within the physiologic excursion of muscle-tendon unit: a rabbit model

    Directory of Open Access Journals (Sweden)

    Chen Pei-Yu

    2007-08-01

    Full Text Available Abstract Background and Purpose Intensive eccentric exercise can cause muscle damage. We simulated an animal model of isokinetic eccentric exercise by repetitively stretching stimulated triceps surae muscle-tendon units to determine if such exercise affects the mechanical properties of the unit within its physiologic excursion. Methods Biomechanical parameters of the muscle-tendon unit were monitored during isokinetic eccentric loading in 12 rabbits. In each animal, one limb (control group was stretched until failure. The other limb (study group was first subjected to isokinetic and eccentric cyclic loading at the rate of 10.0 cm/min to 112% (group I or 120% (group II of its initial length for 1 hour and then stretched to failure. Load-deformation curves and biomechanical parameters were compared between the study and control groups. Results When the muscle-tendon unit received eccentric cyclic loading to 112%, changes in all biomechanical parameters – except for the slope of the load-deformation curve – were not significant. In contrast, most parameters, including the slope of the load-deformation curve, peak load, deformation at peak load, total energy absorption, and energy absorption before peak load, significantly decreased after isokinetic eccentric cyclic loading to 120%. Conclusion We found a threshold for eccentrically induced injury of the rabbit triceps surae muscle at between 12% and 20% strain, which is within the physiologic excursion of the muscle-tendon units. Our study provided evidence that eccentric exercise may induce changes in the biomechanical properties of skeletal muscles, even within the physiologic range of the excursion of the muscle-tendon unit.

  18. Phosphogenesis associated with the Shuram Excursion: Petrographic and geochemical observations from the Ediacaran Doushantuo Formation of South China

    Science.gov (United States)

    Cui, Huan; Xiao, Shuhai; Zhou, Chuanming; Peng, Yongbo; Kaufman, Alan J.; Plummer, Rebecca E.

    2016-07-01

    The Ediacaran Period witnessed one of the largest phosphogenic events in Earth's history. Coincidently, some phosphorite deposits in South China are associated with the largest-known carbon isotope negative excursion (i.e., Shuram Excursion), suggesting an intimate coupling of the biogeochemical carbon and phosphorous cycles. However, the geomicrobiological linkage between these anomalies remain poorly understood. In this study, we investigated the phosphorite samples from the uppermost Doushantuo Formation in South China. Carbon isotope compositions of authigenic calcite cements and nodules in the phosphorites are as low as -34‰ (VPDB). Petrographic and geochemical investigations indicate that the 13C-depleted carbonates likely formed as the result of microbial sulfate and iron reduction that released phosphorous from iron oxyhydroxide, concentrating phosphorous in pore waters, and thereby promoting phosphate mineralization. The timing of this event appears to coincide with enhanced sulfate delivery to seawater through continental weathering. The basin-scale distribution of Doushantuo phosphorites suggests a redox control on the availability of iron oxyhydroxide and the recycling of pore water phosphorous. Both inner and outer shelf regions were likely characterized by an oxic water column, and were the main loci for phosphogenesis; on the contrary, intra-shelf and slope regions, which are lean in phosphorite, were subjected to euxinic or ferruginous water column conditions. The intimate coupling between Ediacaran phosphogenesis and the Shuram Excursion suggests strong links among seawater redox conditions, C-S-P-Fe cycling, and fossil phosphatization. Increased microbial sulfate reduction driven by enhanced sulfate reservoir in the Ediacaran ocean may have played an essential role on these biogeochemical events.

  19. An Ocean Acidification Pulse in the Pre-onset Carbon Isotope Excursion Preceding the Paleocene-Eocene Thermal Maximum

    Science.gov (United States)

    Robinson, M. M.; Self-Trail, J. M.; Willard, D. A.; Stassen, P.; Spivey, W.

    2015-12-01

    The Paleocene-Eocene Thermal Maximum (PETM; ~55.5 Ma) is recognized globally in marine sediments by a carbonate dissolution zone, the extinction or turnover of benthic taxa, and a radiation of planktic excursion taxa, all accompanied by a rapid-onset, negative carbon isotope excursion (CIE). The cause and nature of the massive carbon release leading to this extreme climate event remains under debate. Regardless of cause, the environmental and ecosystem changes centered on the PETM are the subject of much study because they provide an analog to modern deteriorating conditions associated with the ongoing rise in atmospheric carbon dioxide. We present evidence from sediments of the South Dover Bridge core, deposited on the U.S. mid-Atlantic shelf, for an ocean acidification event in the latest Paleocene that coincides with a relatively small (-2‰) negative carbon isotope excursion (CIE) that precedes the larger (-4‰) Paleocene-Eocene CIE onset. Planktic foraminifers during this pre-onset event (POE) show post-deposition dissolution in which the coarsely cancellate and muricate wall textures characteristic of many Late Paleocene species have been dissolved away, leaving smooth, thin-walled specimens often with collapsed chambers. In addition, we document biotic responses in benthic, planktic, and terrestrial communities to the POE, including shifts in foraminifer and pollen assemblages and adaptations in calcareous nannofossil species in response to environmental perturbations. A complete recovery is evident between the POE and CIE in both the carbon isotopic signal and in the biotic response, providing additional evidence not only for a pulsed carbon release, but also for a more rapid rate of carbon release than is suggested by a single pulse over a longer period of time. The timing, nature and magnitude of ecological changes during the less extreme POE shallow water acidification event may help to define the ecological tipping point of shallow marine ecosystems.

  20. An introduction to finite projective planes

    CERN Document Server

    Albert, Abraham Adrian

    2015-01-01

    Geared toward both beginning and advanced undergraduate and graduate students, this self-contained treatment offers an elementary approach to finite projective planes. Following a review of the basics of projective geometry, the text examines finite planes, field planes, and coordinates in an arbitrary plane. Additional topics include central collineations and the little Desargues' property, the fundamental theorem, and examples of finite non-Desarguesian planes.Virtually no knowledge or sophistication on the part of the student is assumed, and every algebraic system that arises is defined and

  1. Excursions into the Evolution of Early-Type Galaxies in Clusters

    CERN Document Server

    López-Cruz, O; Barrientos, L F; Gladders, M D; Yee, H K C; Kodama, T; Lopez-Cruz, Omar; Schade, David; Gladders, Michael D.

    2002-01-01

    Recent observations have revealed that early-type galaxies (ETG) in clusters comprise an old galaxy population that is evolving passively. We review some recent observations from the ground and from HST that show that ETG have undergone a significant amount of luminosity evolution. This evolution is traced by two projections of the fundamental plane (FP): the size-magnitude relation (SMR) and the color-magnitude relation (CMR). We will briefly discuss the relevance of all these results in the context of the universality of the IMF.

  2. Thermodynamics of black plane solution

    CERN Document Server

    Rodrigues, Manuel E; Houndjo, Stéphane J M

    2012-01-01

    We obtain a new phantom black plane solution in 4D of the Einstein-Maxwell theory coupled with a cosmological constant. We analyse their basic properties and obtain the extensive and intensive thermodynamic variables, as well as the specific heat and the first law. Through the specific heat and the so-called geometric methods, we analyse in detail their thermodynamic properties, the extreme and phase transition limits, as well as the local and global stabilities of the system. The normal case is shown with an extreme limit and the phantom one with a phase transition only for null mass. The systems present local and global stabilities for certain values of the entropy density with respect to the electric charge, for the canonical and grand canonical ensembles.

  3. Thermodynamics of black plane solution

    Science.gov (United States)

    Rodrigues, Manuel E.; Jardim, Deborah F.; Houndjo, Stéphane J. M.; Myrzakulov, Ratbay

    2013-11-01

    We obtain a new phantom black plane solution in D of the Einstein-Maxwell theory coupled with a cosmological constant. We analyse their basic properties, as well as its causal structure, and obtain the extensive and intensive thermodynamic variables, as well as the specific heat and the first law. Through the specific heat and the so-called geometric methods, we analyse in detail their thermodynamic properties, the extreme and phase transition limits, as well as the local and global stabilities of the system. The normal case is shown with an extreme limit and the phantom one with a phase transition only for null mass, which is physically inaccessible. The systems present local and global stabilities for certain values of the entropy density with respect to the electric charge, for the canonical and grand canonical ensembles.

  4. On plane submerged laminar jets

    Science.gov (United States)

    Coenen, Wilfried; Sanchez, Antonio L.

    2016-11-01

    We address the laminar flow generated when a developed stream of liquid of kinematic viscosity ν flowing along channel of width 2 h discharges into an open space bounded by two symmetric plane walls departing from the channel rim with an angle α 1 . Attention is focused on values of the jet volume flux 2 Q such that the associated Reynolds number Re = Qh / ν is of order unity. The formulation requires specification of the boundary conditions far from the channel exit. If the flow is driven by the volume flux, then the far-field solution corresponds to Jeffery-Hamel self-similar flow. However, as noted by Fraenkel (1962), such solutions exist only for α potential flow driven by the jet entrainment, and a Falkner-Skan near-wall boundary layer. Numerical integrations of the Navier-Stokes equations are used to ascertain the existence of these different solutions.

  5. 1-D Systolic Arrays Design of LMS Adaptive (FIR Digital Filtering

    Directory of Open Access Journals (Sweden)

    Ali H. Mahdi

    2010-01-01

    Full Text Available This paper extends the 1-D systolic array approach with a method of systematic linear design of systolic algorithms. Past methods for mapping the Least-Mean-Square (LMS Adaptive Finite-Impulse-Response (FIR filter onto parallel and pipelined architectures either introduce delays in the coefficients updates or have excessive hardware requirements. In this article, we describe an efficient 1-D systolic array for the LMS adaptive FIR filter that produces the same output and error signals as produced by the standard LMS adaptive filter architecture with single assignment form of processor functions.The proposed systolic architectures that are designed operate on a block-by-block basis and makes use of the flexibility in the design, which takes the inner product step (convolution sum of the tap weight vector and the tap input vector in the design consideration. It enables us to extract more than one algorithm for the same problem. The input and output data flow sequentially and continuously into and out of the systolic arrays at the system clock rates, during each clock period, processing element of the same type operates in parallel. The most computationally demanding among them performs only two consecutive multiplications and two additions/subtractions per clock period, thereby allowing a very high throughput and very fast block signal processing to be achieved at the expense of a delay of L samples between the input and output and 100% utilization, L being the block size.

  6. Similarities and Differences between the Pathogenesis and Pathophysiology of Diastolic and Systolic Heart Failure

    Directory of Open Access Journals (Sweden)

    Kazuo Komamura

    2013-01-01

    Full Text Available Pathophysiology of heart failure has been considered to be a damaged state of systolic function of the heart followed by a state of low cardiac output that is, systolic heart failure. Even if systolic function is preserved, left ventricular filling in diastole can be impeded and resulted in elevation of filling pressure and symptoms of heart failure. This kind of heart failure is called diastolic heart failure. Nowadays, diastolic heart failure is referred to as heart failure with preserved ejection fraction (HFpEF, whereas systolic heart failure is referred to as heart failure with reduced ejection fraction (HFrEF. In this paper, the similarities and differences between the pathogenesis and pathophysiology of diastolic and systolic heart failure were reviewed. Although diastolic heart failure is a common condition of heart failure worldwide, its pathophysiology has not been sufficiently elucidated. This is thought to be the most significant reason for a lack of established treatment methods for diastolic heart failure. We hope to proceed with future studies on this topic.

  7. Effect of myocardial ischemia and nitroglycerin on systolic time intervals in the segmental myocardium

    Directory of Open Access Journals (Sweden)

    Haraoka,Shoichi

    1978-04-01

    Full Text Available Effects of ischemia and nitroglycerin on systolic time intervals in the segmental myocardial length were studied in anesthetized open-chest dogs. Two strain-gauges were sutured on the surface of the left ventricular wall; one was in the central area perfused by the left circumflex coronary artery (LCX and the other was in the area perfused by the left anterior descending coronary artery. LCX was partially occluded with a screw type constrictor to the degree at which reactive hyperemia after the transient total coronary occlusion almost disappeared. After the hemodynamics stabilized nitroglycerin (20 microgram/kg was injected into the femoral vein. In the ischemic area, contraction time was shortened and precontraction time was prolonged in association with an elongation of end-systolic and early systolic segment-length, respectively. The systolic time intervals in the ischemic segment were improved as a result of the recovery in the segment-length toward the control. The results suggest the usefulness of analyzing the segmental myocardial systolic time intervals for verifying the asynchronous contraction of the ventricle and the favourable effects of nitroglycerin on segmental myocardial function in the ischemic area.

  8. Differential Diagnosis and Treatment Rates Between Systolic and Diastolic Hypertension in Young Adults: A Multi-Disciplinary Observational Study

    Science.gov (United States)

    Johnson, Heather M.; Bartels, Christie M.; Thorpe, Carolyn T.; Schumacher, Jessica R.; Pandhi, Nancy; Smith, Maureen A.

    2015-01-01

    Differential rates of diagnosis and treatment by hypertension type may contribute to poor hypertension control in young adults. Our objective was to compare rates of receiving a hypertension diagnosis and antihypertensive among young adults with 1) isolated systolic, 2) isolated diastolic, and 3) combined systolic/diastolic. A retrospective analysis was conducted of 18-39 year-olds (n=3003) with incident hypertension. Kaplan-Meier survival and Cox proportional hazards analyses were performed. Only 56% with isolated systolic received a diagnosis compared to 63% (systolic/diastolic); 32% with isolated systolic received an initial antihypertensive compared to 52% (systolic/diastolic). Compared to systolic/diastolic, isolated systolic had a 50% slower diagnosis rate (HR 0.50; 0.41–0.60) and isolated diastolic had a 26% slower rate (HR 0.74; 0.60–0.92). Isolated systolic had 58% slower medication initiation (HR 0.42; 0.34–0.51); isolated diastolic had 31% slower rates (HR 0.69; 0.55–0.86). Young adults with isolated systolic hypertension have lower diagnosis and treatment rates. PMID:26073687

  9. Differential Diagnosis and Treatment Rates Between Systolic and Diastolic Hypertension in Young Adults: A Multidisciplinary Observational Study.

    Science.gov (United States)

    Johnson, Heather M; Bartels, Christie M; Thorpe, Carolyn T; Schumacher, Jessica R; Pandhi, Nancy; Smith, Maureen A

    2015-11-01

    Differential rates of diagnosis and treatment by hypertension (HTN) type may contribute to poor HTN control in young adults. The objective of this study was to compare rates of receiving a hypertension diagnosis and antihypertensive agent among young adults with (1) isolated systolic, (2) isolated diastolic, and (3) combined systolic/diastolic HTN. A retrospective analysis was conducted in patients aged 18 to 39 years (n=3003) with incident HTN. Kaplan-Meier survival and Cox proportional hazards analyses were performed. Only 56% with isolated systolic HTN received a diagnosis compared with 63% (systolic/diastolic); 32% with isolated systolic HTN received an initial antihypertensive compared with 52% (systolic/diastolic). Compared with patients with systolic/diastolic HTN, those with isolated systolic HTN had a 50% slower diagnosis rate (hazard ratio [HR], 0.50; 95% confidence interval [CI], 0.41-0.60) and those with isolated diastolic HTN had a 26% slower rate (HR, 0.74; CI, 0.60-0.92). Patients with isolated systolic HTN had 58% slower medication initiation (HR, 0.42; CI, 0.34-0.51) and those with isolated diastolic HTN had 31% slower rates (HR, 0.69; CI, 0.55-0.86). Young adults with isolated systolic HTN have lower diagnosis and treatment rates. © 2015 Wiley Periodicals, Inc.

  10. Statistical Model of Secular Variation and Excursions and Drilling to the Moho

    Science.gov (United States)

    Harrison, C. G.

    2007-12-01

    Almost all models for Earth's magnetic field secular variation derived from paleomagnetic results disregard results that give low latitude Virtual Geomagnetic Poles (VGPs). These results are regarded as "unusual" or "not part of the regular secular variation process". These low latitude VGPs are regarded as being produced at a time when the field is undergoing an excursion or a reversal and that therefore they should not be included in a secular variation study. However, it is almost impossible to determine logically the latitude of VGP below which results should be dismissed from study of the secular variation. And for some studies, it is important to include all results to arrive at a valid conclusion. This is the case with the paleomagnetic evidence that will be collected during the drilling through the oceanic crust to the Mohorovicic discontinuity, marking the top of the mantle. Accordingly, the results from the data set originally used by McElhinny and McFadden (1997) updated by addition of new results was expanded to include all the results giving low latitude VGPs that were left out of the updated data set. These expanded results were subjected to statistical analysis based on different latitude bands of the observation sites. This showed that for all latitude bands, the Fisher distribution gave a very bad fit to the data. However the data from every observational latitude band could be fitted by a Fisher distribution for about 90% of the data, plus a uniform distribution in latitude for the other 10% of the data. In addition, the Fisher distribution angular standard deviation showed a linear increase with observation latitude, rising from 11.5º at 10º latitude to 20º at 66º latitude. These results can be used to define a simple model which allows us to estimate the scatter to be found at any latitude, and in particular to determine the scatter in inclination that would be obtained from unoriented samples of basalt recovered during the Integrated Ocean

  11. Generalized plane gravitational waves of non-symmetric unified field theories in plane symmetry

    Directory of Open Access Journals (Sweden)

    Sanjiv R. Bhoyar

    2012-12-01

    Full Text Available In this paper we investigated the plane wave solutions of both the weak and strong non-symmetric unified field equations of Einstein and Bonner in a generalized plane symmetric space-time in the sense of Taub [Ann. Math. 53, 472 (1951] for plane gravitational waves. We show that the plane wave solutions of Einstein and Bonner field equations exist in plane symmetry.

  12. Effects of preoperative inspiratory muscle training in obese women undergoing open bariatric surgery: respiratory muscle strength, lung volumes, and diaphragmatic excursion

    Directory of Open Access Journals (Sweden)

    Marcela Cangussu Barbalho-Moulim

    2011-01-01

    Full Text Available OBJECTIVE: To determine whether preoperative inspiratory muscle training is able to attenuate the impact of surgical trauma on the respiratory muscle strength, in the lung volumes, and diaphragmatic excursion in obese women undergoing open bariatric surgery. DESIGN: Randomized controlled trial. SETTING: Meridional Hospital, Cariacica/ES, Brazil. SUBJECTS: Thirty-two obese women undergoing elective open bariatric surgery were randomly assigned to receive preoperative inspiratory muscle training (inspiratory muscle training group or usual care (control group. MAIN MEASURES: Respiratory muscle strength (maximal static respiratory pressure - maximal inspiratory pressure and maximal expiratory pressure, lung volumes, and diaphragmatic excursion. RESULTS: After training, there was a significant increase only in the maximal inspiratory pressure in the inspiratory muscle training group. The maximal expiratory pressure, the lung volumes and the diaphragmatic excursion did not show any significant change with training. In the postoperative period there was a significant decrease in maximal inspiratory pressure in both the groups. However, there was a decrease of 28% in the inspiratory muscle training group, whereas it was 47% in the control group. The decrease in maximal expiratory pressure and in lung volumes in the postoperative period was similar between the groups. There was a significant reduction in the measures of diaphragmatic excursion in both the groups. CONCLUSION: The preoperative inspiratory muscle training increased the inspiratory muscle strength (maximal inspiratory pressure and attenuated the negative postoperative effects of open bariatric surgery in obese women for this variable, though not influencing the lung volumes and the diaphragmatic excursion.

  13. Vector flow imaging of the ascending aorta. Are systolic backflow and atherosclerosis related?

    DEFF Research Database (Denmark)

    Hansen, Kristoffer Lindskov; Møller-Sørensen, Hasse; Kjaergaard, Jesper

    2015-01-01

    In the ascending aorta, atherosclerotic plaque formation, which is a risk factor for cerebrovascular events, most often occurs along the inner curvature. Atherosclerosis is a multifactorial disease, but the predilection site for the aortic vessel degradation is probably flow dependent. To better...... understand the aortic flow and especially the complex flow patterns, the ascending aorta was scanned intraoperatively in patients undergoing heart surgery using the angle-independent vector velocity ultrasound method Transverse Oscillation (TO). The primary aim of the study was to analyze systolic backflow...... on the ascending aorta in long axis view. The presence of systolic backflow, visualized with TO, was correlated to aortic atherosclerosis, to systolic velocities obtained with transesophageal echocardiography and cardiac output obtained with pulmonary artery catheter thermodilution, to gender, age, aortic diameter...

  14. Long-term L-Triiodothyronine (T3) treatment in stable systolic heart failure patients

    DEFF Research Database (Denmark)

    Holmager, Pernille; Schmidt, Ulla; Mark, Peter

    2015-01-01

    during T3-treatment and neither did the neurohormonal profile. There were no side-effects in terms of cardiac arrhythmias and no change in resting heart rate. CONCLUSIONS: This study does not support the hypothesis that oral T3 treatment might be beneficial to patients with chronic, stable systolic HF......BACKGROUND: Chronic heart failure (HF) is characterized by reduced serum T3 levels and increased activity of the T3 degrading enzyme deiodinase D3. This may result in an intracellular composition of the cardiomyocyte mimicking that of hypothyroidism. Short-term T3-administration to systolic HF...... patients might be beneficial. QUESTION: Does long-term treatment with T3 have a beneficial effect on cardiac function and neurohormonal activation in chronic systolic HF patients with serum T3 levels below 1·6 nmol/l? DESIGN: A randomized, double-blind, cross-over, placebo-controlled intervention study...

  15. Effects of Atorvastatin on Warfarin-induced Aortic Medial Calcification and Systolic Blood Pressure in Rats

    Institute of Scientific and Technical Information of China (English)

    Chengyun LIU; Jingjing WAN; Qunfang YANG; Benling QI; Wen PENG; Xuelin CHEN

    2008-01-01

    Summary: The effect of atorvastatin on warfarin-induced aortic medial calcification and systolic blood pressure (SBP) of rats induced by warfarin was studied. Thirty healthy and adult rats were randomly divided into Warfarin group (n=10), Atorvastatin group (n=10) and normal control group (n=10). Caudal arterial pressure of rats was measured once a week, and 4 weeks later, aorta was obtained. Elastic fiber, collagen fiber and calcium accumulation in tunica media of cells were measured by Von Kossa staining. The results showed that warfarin treatment led to elevation of systolic blood pressure and aortic medial calcification. The chronic treatment also increased collagen, but decreased elastin in the aorta. However, the atorvastatin treatment had adverse effects. It was concluded that treatment with atorvastatin presented evidence of blood pressure lowing and calcification reducing. These data demonstrate that atorvastatin protected aortic media from warfarin-induced calcification and elevation of systolic blood pressure.

  16. Impact of order of movement on nerve strain and longitudinal excursion: a biomechanical study with implications for neurodynamic test sequencing.

    Science.gov (United States)

    Nee, Robert J; Yang, Chich-Haung; Liang, Chung-Chao; Tseng, Guo-Fang; Coppieters, Michel W

    2010-08-01

    It is assumed that strain in a nerve segment at the end of a neurodynamic test will be greatest if the joint nearest that nerve segment is moved first in the neurodynamic test sequence. To test this assumption, the main movements of the median nerve biased neurodynamic test were applied in three different sequences to seven fresh-frozen human cadavers. Strain and longitudinal excursion were measured in the median nerve at the distal forearm. Strain and relative position of the nerve at the end of a test did not differ between sequences. The nerve was subjected to higher levels of strain for a longer duration during the sequence where wrist extension occurred first. The pattern of excursion was different for each sequence. The results highlight that order of movement does not affect strain or relative position of the nerve at the end of a test when joints are moved through comparable ranges of motion. When used clinically, different neurodynamic sequences may still change the mechanical load applied to a nerve segment. Changes in load may occur because certain sequences apply increased levels of strain to the nerve for a longer time period, or because sequences differ in ranges of joint motions.

  17. Accidental nuclear excursion Recuplex operation 234-5 facility. Final report: Date of incident: April 7, 1962

    Energy Technology Data Exchange (ETDEWEB)

    1962-08-01

    On Saturday morning, April 7, 1962, at about 1059 Armed Forces time, an accidental nuclear excursion occurred in the plutonium waste recovery facility (Recuplex) of the 234-5 Building. This excursion did not result in any mechanical damage or spread of contamination. Three employees of the General Electric Company received overexposures to gamma and neutron radiation. None were fatally exposed; in each case the overexposure was recognized promptly, and following medical observation and testing the men were released to return to work. In compliance with AEC Manual Chapter 0703, an AEC-HAPO committee composed of two AEC employees and five General Electric employees was appointed by the Manger, HOO, with the concurrence of the General Manager, HAPO, to conduct an investigation of the incident. The committee`s purpose was to determine the cause, nature, and extent of the incident, and recommend action to be taken by others to minimize or preclude future incidents of this magnitude. A study of operating practices and operating conditions that appeared to exist prior to, during, and subsequent to the accident was made by the committee. The committee believes that this report provides sufficient information to answer questions which may arise as a result of the criticality incident except those relating to its cause.

  18. The use of normalized cross-correlation analysis for automatic tendon excursion measurement in dynamic ultrasound imaging.

    Science.gov (United States)

    Pearson, Stephen J; Ritchings, Tim; Mohamed, Ahmad S A

    2013-04-01

    The work describes an automated method of tracking dynamic ultrasound images using a normalized cross-correlation algorithm, applied to the patellar and gastrocnemius tendon. Displacement was examined during active and passive tendon excursions using B-mode ultrasonography. In the passive test where two regions of interest (2-ROI) were tracked, the automated tracking algorithm showed insignificant deviations from relative zero displacement for the knee (0.01 ± 0.04 mm) and ankle (-0.02 ± 0.04 mm) (P > .05). Similarly, when tracking 1-ROI the passive tests showed no significant differences (P > .05) between automatic and manual methods, 7.50 ± 0.60 vs 7.66 ± 0.63 mm for the patellar and 11.28 ± 1.36 vs 11.17 ± 1.35 mm for the gastrocnemius tests. The active tests gave no significant differences (P > .05) between automatic and manual methods with differences of 0.29 ± 0.04 mm for the patellar and 0.26 ± 0.01 mm for the gastrocnemius. This study showed that automatic tracking of in vivo displacement of tendon during dynamic excursion under load is possible and valid when compared with the standardized method. This approach will save time during analysis and enable discrete areas of the tendon to be examined.

  19. A virtual, interactive and dynamic excursion in Google Earth on soil management and conservation (AgroGeovid)

    Science.gov (United States)

    Vanwalleghem, Tom; Giráldez, Juan Vicente

    2013-04-01

    Many courses on natural resources require hands-on practical knowledge and experience that students traditionally could only acquire by expensive and time-consuming field excursions. New technologies and social media however provide an interesting alternative to train students and help them improve their practical knowledge. AgroGeovid is a virtual excursion, based on Google Earth, Youtube, Facebook and Twitter that is aimed at agricultural engineering students, but equally useful for any student interested in soil management and conservation, e.g. geography, geology and environmental resources. Agrogeovid provides the framework for teachers and students to upload geotagged photos, comments and discussions. After the initial startup phase, where the teacher uploaded material on e.g. soil erosion phenomena, soil conservation structures and different soil management strategies under different agronomic systems, students contributed with their own material gathered throughout the academic year. All students decided to contribute via Facebook, in stead of Twitter, which was not known to most of them. The final result was a visual and dynamic tool which students could use to train and perfect skills adopted in the classroom using case-studies and examples from their immediate environment.

  20. Influence of glycemic excursion on urinary albumin excretion and inflammatory factor in early diabetes kidney disease patients

    Institute of Scientific and Technical Information of China (English)

    Xuan Cao; Ding-Ping Yang

    2016-01-01

    Objective:To research the influence of glycemic excursion on the level of urinary albumin excretion and inflammatory factor in early diabetes kidney disease patients.Methods:From January to December in 2015, 96 confirmed cases of early diabetes kidney disease were collected. Continuous Glucose Monito Ring System CGMS, produced by American MiniMed Inc) was used to monitor 72 h blood glucose. The influence of MAGE on the level of urinary albumin excretion, IGF-1, FKN, IL-6, TNF-α, hs-CRP and inflammatory indexes was compared.Results:Compared cases of stable blood sugar (MAGE<5.0 mmol/L) with unstable ones (MAGE≥5.0 mmol/L), the difference of UAER and 1,5-AG had statistical significance, while HbA1c and FA had no significant difference. Pearson correlation analysis between MAGE and UAER resulted in strong correlation. And also the front inflammatory factor including IGF-1, FKN, IL-6, TNF-α, hs-CRP all showed lower level than the cases of MAGE≥5.0 mmol/L.Conclusion:Glycemic excursion may accelerate development of kidney injury through inflammatory factors.

  1. The impact of animation on the length of stay and radius of movement of the excursion-recreational tourism

    Directory of Open Access Journals (Sweden)

    Dimitrić Dragana

    2016-01-01

    Full Text Available The basic hypothesis from which we started in the paper is the claim that animation of visitors has a direct impact on the length and radius of excursion-recreational tourism. The main objective of the research is to define the role of animation in the choice of tourist destination and length of staying. In the area of the City of Belgrade, there are more protected natural areas and one of them is the Great War Island located at the confluence of the River Sava in River Danube. This area has three protected zones. Temporary population that was the subject of the interview, as well as the Association of Tourist Guides of Serbia occupate one of these zones. We concluded that one of the biggest advantages of developing tourism of the Great War Island is the possibility of developing certain forms of tourism, and one of these forms, the excursion-recreational tourism has multiple positive effects on the population. The paper concluded that the animation proportionally affects the length of stay of tourists, as well as the radius of their movement.

  2. The reliability of toe systolic pressure and the toe brachial index in patients with diabetes

    Directory of Open Access Journals (Sweden)

    Perrin Byron M

    2010-12-01

    Full Text Available Abstract Background The Ankle Brachial Index is a useful clinical test for establishing blood supply to the foot. However, there are limitations to this method when conducted on people with diabetes. As an alternative to the Ankle Brachial Index, measuring Toe Systolic Pressures and the Toe Brachial Index have been recommended to assess the arterial blood supply to the foot. This study aimed to determine the intra and inter-rater reliability of the measurement of Toe Systolic Pressure and the Toe Brachial Index in patients with diabetes using a manual measurement system. Methods This was a repeated measures, reliability study. Three raters measured Toe Systolic Pressure and the Toe Brachial Index in thirty participants with diabetes. Measurement sessions occurred on two occasions, one week apart, using a manual photoplethysmography unit (Hadeco Smartdop 45 and a standardised measurement protocol. Results The mean intra-class correlation for intra-rater reliability for toe systolic pressures was 0.87 (95% LOA: -25.97 to 26.06 mmHg and the mean intra-class correlation for Toe Brachial Indices was 0.75 (95% LOA: -0.22 to 0.28. The intra-class correlation for inter-rater reliability was 0.88 for toe systolic pressures (95% LOA: -22.91 to 29.17.mmHg and 0.77 for Toe Brachial Indices (95% LOA: -0.21 to 0.22. Conclusion Despite the reasonable intra-class correlation results, the range of error (95% LOA was broad. This raises questions regarding the reliability of using a manual sphygmomanometer and PPG for the Toe Systolic Pressure and Toe Brachial Indice.

  3. Assessment of left ventricular systolic and diastolic function in juvenile rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    Bharti Bishwa Bhushan

    2004-10-01

    Full Text Available Background and Aims: Recognizing the paucity of data regarding echocardiographic studies of Left ventricular (LV systolic and diastolic function in patients with juvenile rheumatoid arthritis (JRA, a study was carried out to study these parameters in these subjects. Settings, Design and Methods: Thirty-five patients with JRA and an equal number of age- and sex-matched controls were studied by two-dimensional and Doppler echocardiography. Results: Patients with JRA had higher systolic and diastolic blood pressures, resting heart rates, LV systolic (26.9±4.3 vs. 22.4 ± 4.1 mm, p=0.001 and diastolic size (42.3±4.6 vs. 35.4±3.8 mm, p<0.001 and volumes. Though ejection fraction (EF and fractional shortening (FS were normal, they were lower in those with JRA as compared to controls (EF: 62.9±4.47 vs. 67.5±3.63 %, p<0.001; FS: 36.4±4.5 vs. 38.5 ± 6.87, p=0.2. On Doppler analysis the JRA group had lower peak E velocity, higher peak A velocity, higher A VTI and more prolonged IVRT. Male patients had higher A VTI and IVRT as compared to females. Those with longer duration of disease had larger LV systolic (r=0.517, p=0.01 and diastolic dimension (r=0.40, p=0.05 and lower FS (r=-0.506, p=0.01. Patients with polyarticular JRA had higher E and A VTI as compared to those with systemic or oligoarticular types. Conclusion: Despite an asymptomatic cardiac status, significant systolic and diastolic functional abnormalities exist in patients with JRA. The duration of the disease, mode of presentation, patient's age and gender have a significant impact on the left ventricular systolic and diastolic functions in patients with JRA.

  4. Systematic review and meta-analysis of preterm birth and later systolic blood pressure.

    Science.gov (United States)

    de Jong, Femke; Monuteaux, Michael C; van Elburg, Ruurd M; Gillman, Matthew W; Belfort, Mandy B

    2012-02-01

    Lower birth weight because of fetal growth restriction is associated with higher blood pressure later in life, but the extent to which preterm birth (blood pressure is less clear. We performed a systematic review of 27 observational studies that compared the resting or ambulatory systolic blood pressure or diagnosis of hypertension among children, adolescents, and adults born preterm or very low birth weight with those born at term. We performed a meta-analysis with the subset of 10 studies that reported the resting systolic blood pressure difference in millimeters of mercury with 95% CIs or SEs. We assessed methodologic quality with a modified Newcastle-Ottawa Scale. The 10 studies were composed of 1342 preterm or very low birth weight and 1738 term participants from 8 countries. The mean gestational age at birth of the preterm participants was 30.2 weeks (range: 28.8-34.1 weeks), birth weight was 1280 g (range: 1098-1958 g), and age at systolic blood pressure measurement was 17.8 years (range: 6.3-22.4 years). Former preterm or very low birth weight infants had higher systolic blood pressure than term infants (pooled estimate: 2.5 mm Hg [95% CI: 1.7-3.3 mm Hg]). For the 5 highest quality studies, the systolic blood pressure difference was slightly greater, at 3.8 mm Hg (95% CI: 2.6-5.0 mm Hg). We conclude that infants who are born preterm or very low birth weight have modestly higher systolic blood pressure later in life and may be at increased risk for developing hypertension and its sequelae.

  5. Pulsed Doppler Tissue Imaging for Assessment of Left Ventricular Systolic and Diastolic Synchronicity in Normal Subjects

    Institute of Scientific and Technical Information of China (English)

    Yang Li; Wu Wei; Wang Jingfeng; Zhang Xiaoling

    2006-01-01

    Objectives To quantitatively analyze the longitudinal myocardial systolic and diastolic velocities and time intervals of the left ventricle in normal subjects, and to explore the value of pulsed Doppler tissue imaging (DTI) for the assessment of left ventricular systolic and diastolic synchronicity.Methods Twenty and six healthy subjects were studied by pulsed DTI. The septal and lateral, anterior and inferior walls of the left ventricle were displayed respectively, and basal and middle segments of each wall were selected for myocardial motion spectrum sampling. DTI parameters were: peak systolic myocardial velocity (s), regional pre-ejection period (PEP), time to the peak of s wave (Ts), regional ejection time (ET); peak early diastolic velocity (e),peak late diastolic velocity (a), e/a ratio, time to the beginning of e wave (QE), time to the peak of e wave (Te) and regional isovolumic relaxation time (IVRT).Results The e and e/a were significantly different among basal segments, and s and e/a were significantly different among middle segments, with the highest value in lateral segments and the lowest value in septal segments. The s, e and a were all significantly higher in basal segments than middle segments. None of the systolic time intervals (PEP, Ts and ET) and diastolic time intervals (QE, Te and IVRT) were significantly different among basal segments and middle segments,neither were they when basal segment was compared with middle segment. Conclusions In normal subjects, the longitudinal myocardial systolic and diastolic velocities of the left ventricle are not homogeneous, but the contraction and relaxation are highly synchronized. Pulsed DTI can be used to quantitatively analyze the systolic and diastolic synchronicity of the heart.

  6. Iodine-to-calcium ratios in carbonates suggest a primary origin for the Precambrian Lomagundi and Shuram carbon isotope excursions

    Science.gov (United States)

    Hardisty, D. S.; Lu, Z.; Planavsky, N. J.; Osburn, M. R.; Bekker, A.; Lyons, T. W.

    2013-12-01

    Systematic increases in iodine-to-calcium ratios (I/Ca) in carbonates from both the Precambrian Lomagundi and Shuram carbonate carbon isotope (δ13Ccarb) excursion intervals suggest primary origins for these events. Iodate (IO3-), the oxidized iodine species, is the exclusive species incorporated into carbonates. The high redox sensitivity of IO3- to deoxygenation requires highly oxidizing fluids for IO3- production, making I/Ca in platform carbonates a simple indicator of the presence of oxidizing fluids in the surface ocean. Similarly, redox sensitivity makes the proxy host susceptible to diagenetic iodine loss during carbonate recrystallization in reducing pore fluids. Recent work has shown carbonates to experience near-complete iodine loss during dolomitization in the Permian, and work from our group evaluating modern and recent carbonates demonstrate the potential for diagenetic iodine loss during carbonate recrystallization. In some cases, however, such as meteoric aragonite-to-calcite transitions, oxidizing pore fluids have the potential to buffer IO3- concentrations, causing negligible alteration to primary I/Ca despite negative shifts in δ13Ccarb. These results highlight that diagenetic alterations to I/Ca and δ13Ccarb need not always be coupled, but importantly, no observed scenario promotes post-depositional addition of iodine to carbonates. This means that, independent of δ13Ccarb, systematic, stratigraphic increases in I/Ca ratios observed in the carbonate record are most easily interpreted as resulting from depositional controls such as surface ocean redox or shifts in the total marine iodine reservoir. From this, increasing I/Ca ratios coincident with rising and falling δ13Ccarb trends for the Paleoproterozic Lomagundi and Neoproterozoic Shuram events, respectively, support suggestions of a primary origin for the δ13Ccarb excursions. Significant increase in I/Ca in dolomites deposited during the Lomagundi excursion, rising from blank values in

  7. Left atrial systolic force in hypertensive patients with left ventricular hypertrophy: the LIFE study

    DEFF Research Database (Denmark)

    Chinali, M.; Simone, G. de; Wachtell, K.;

    2008-01-01

    systolic force and left ventricular geometry and function have not been investigated in high-risk hypertrophic hypertensive patients. Participants in the Losartan Intervention For Endpoint reduction in hypertension echocardiography substudy without prevalent cardiovascular disease or atrial fibrillation (n......In hypertensive patients without prevalent cardiovascular disease, enhanced left atrial systolic force is associated with left ventricular hypertrophy and increased preload. It also predicts cardiovascular events in a population with high prevalence of obesity. Relations between left atrial...... with larger left ventricular diameter and higher left ventricular mass index (both P ventricular hypertrophy was greater (84 vs. 64%; P

  8. Decreasing systolic blood pressure and declining mortality rates in an untreated population

    DEFF Research Database (Denmark)

    Andersen, Ulla O; Marott, Jacob L; Jensen, Gorm B

    2011-01-01

    The aim of the present study was to evaluate developments in 30 years mortality risk that may be associated with developments in population systolic blood pressure (SBP) and to evaluate possible secular trends in BP-associated mortality risk in the untreated population.......The aim of the present study was to evaluate developments in 30 years mortality risk that may be associated with developments in population systolic blood pressure (SBP) and to evaluate possible secular trends in BP-associated mortality risk in the untreated population....

  9. Constant-load versus heart rate-targeted exercise - Responses of systolic intervals

    Science.gov (United States)

    Lance, V. Q.; Spodick, D. H.

    1975-01-01

    Various systolic intervals were measured prior to and during heart rate-targeted bicycle ergometer exercise. There were striking similarities within each matched exercise set for Q-Im, isovolumetric contraction time, preejection period (PEP), and PEP/left ventricular ejection time (LVET). LVET was significantly shorter for rate-targeted exercise. It is concluded that either constant-load or rate-targeted bicycle ergometry may be used with the choice of method determined by the purpose of the protocol, and that systolic intervals (except LVET) should not be much altered owing to the method chosen.

  10. Circuit for detecting initial systole and dicrotic notch. [for monitoring arterial pressure

    Science.gov (United States)

    Gebben, V. D.; Webb, J. A., Jr. (Inventor)

    1974-01-01

    Circuitry is disclosed for processing an arterial pressure waveform to produce during any one cycle a pulse corresponding to the initial systole and a pulse corresponding to the dicrotic notch. In a first channel, an electrical analog of the arterial pressure waveform is filtered and then compared to the original waveform to produce an initial systole signal. In a second channel, the analog is differentiated, filtered, and fed through a gate controlled by pulses from the first channel to produce an electrical pulse corresponding to the dicrotic notch.

  11. Focal Plane Instrumentation of VERITAS

    CERN Document Server

    Nagai, T; Sleege, G; Petry, D

    2007-01-01

    VERITAS is a new atmospheric Cherenkov imaging telescope array to detect very high energy gamma rays above 100 GeV. The array is located in southern Arizona, USA, at an altitude of 1268m above sea level. The array consists of four 12-m telescopes of Davies-Cotton design and structurally resembling the Whipple 10-m telescope. The four focal plane instruments are equipped with high-resolution (499 pixels) fast photo-multiplier-tube (PMT) cameras covering a 3.5 degree field of view with 0.15 degree pixel separation. Light concentrators reduce the dead-space between PMTs to 25% and shield the PMTs from ambient light. The PMTs are connected to high-speed preamplifiers allowing operation at modest anode current and giving good single photoelectron peaks in situ. Electronics in the focus box provides real-time monitoring of the anode currents for each pixel and ambient environmental conditions. A charge injection subsystem installed in the focus box allows daytime testing of the trigger and data acquisition system b...

  12. Radioactivity in the galactic plane

    Science.gov (United States)

    Walraven, G. D.; Haymes, R. C.

    1976-01-01

    The paper reports the detection of a large concentration of interstellar radioactivity during balloon-altitude measurements of gamma-ray energy spectra in the band between 0.02 and 12.27 MeV from galactic and extragalactic sources. Enhanced counting rates were observed in three directions towards the plane of the Galaxy; a power-law energy spectrum is computed for one of these directions (designated B 10). A large statistical deviation from the power law in a 1.0-FWHM interval centered near 1.16 MeV is discussed, and the existence of a nuclear gamma-ray line at 1.15 MeV in B 10 is postulated. It is suggested that Ca-44, which emits gamma radiation at 1.156 MeV following the decay of radioactive Sc-44, is a likely candidate for this line, noting that Sc-44 arises from Ti-44 according to explosive models of supernova nucleosynthesis. The 1.16-MeV line flux inferred from the present data is shown to equal the predicted flux for a supernova at a distance of approximately 3 kpc and an age not exceeding about 100 years.

  13. A Collaborative Knowledge Plane for Autonomic Networks

    Science.gov (United States)

    Mbaye, Maïssa; Krief, Francine

    Autonomic networking aims to give network components self-managing capabilities. Several autonomic architectures have been proposed. Each of these architectures includes sort of a knowledge plane which is very important to mimic an autonomic behavior. Knowledge plane has a central role for self-functions by providing suitable knowledge to equipment and needs to learn new strategies for more accuracy.However, defining knowledge plane's architecture is still a challenge for researchers. Specially, defining the way cognitive supports interact each other in knowledge plane and implementing them. Decision making process depends on these interactions between reasoning and learning parts of knowledge plane. In this paper we propose a knowledge plane's architecture based on machine learning (inductive logic programming) paradigm and situated view to deal with distributed environment. This architecture is focused on two self-functions that include all other self-functions: self-adaptation and self-organization. Study cases are given and implemented.

  14. RF/Optical Demonstration: Focal Plane Assembly

    Science.gov (United States)

    Hoppe, D. J.; Chung, S.; Kovalik, J.; Gama, E.; Fernandez, M. M.

    2016-11-01

    In this article, we describe the second-generation focal plane optical assembly employed in the RF/optical demonstration at DSS-13. This assembly receives reflected light from the two mirror segments mounted on the RF primary. The focal plane assembly contains a fast steering mirror (FSM) to stabilize the focal plane spot, a pupil camera to aid in aligning the two segments, and several additional cameras for receiving the optical signal prior to as well as after the FSM loop.

  15. Large Format Uncooled Focal Plane Array Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Black Forest Engineering has identified innovative modifications in uncooled focal plane array (UFPA) architecture and processing that allows development of large...

  16. Duration of and decoupling between carbon isotope excursions during the end-Triassic mass extinction and Central Atlantic Magmatic Province emplacement

    Science.gov (United States)

    Yager, Joyce A.; West, A. Joshua; Corsetti, Frank A.; Berelson, William M.; Rollins, Nick E.; Rosas, Silvia; Bottjer, David J.

    2017-09-01

    Changes in δ13Ccarb and δ13Corg from marine strata occur globally in association with the end-Triassic mass extinction and the emplacement of the Central Atlantic Magmatic Province (CAMP) during the break up of Pangea. As is typical in deep time, the timing and duration of these isotopic excursions has remained elusive, hampering attempts to link carbon cycle perturbations to specific processes. Here, we report δ13Ccarb and δ13Corg from Late Triassic and Early Jurassic strata near Levanto, Peru, where intercalated dated ash beds permit temporal calibration of the carbon isotope record. Both δ13Ccarb and δ13Corg exhibit a broad positive excursion through the latest Triassic into the earliest Jurassic. The first order positive excursion in δ13Corg is interrupted by a negative shift noted in many sections around the world coincident with the extinction horizon. Our data indicate that the negative excursion lasts 85 ± 25 kyrs, longer than inferred by previous studies based on cyclostratigraphy. A 260 ± 80 kyr positive δ13Corg shift follows, during which the first Jurassic ammonites appear. The overall excursion culminates in a return to pre-perturbation carbon isotopic values over the next 1090 ± 70 kyrs. Via chronologic, isotopic, and biostratigraphic correlation to other successions, we find that δ13Ccarb and δ13Corg return to pre-perturbation values as CAMP volcanism ceases and in association with the recovery of pelagic and benthic biota. However, the initiation of the carbon isotope excursion at Levanto predates the well-dated CAMP sills from North America, indicating that CAMP may have started earlier than thought based on these exposures, or that the onset of carbon cycle perturbations was not related to CAMP.

  17. Comparison of Diaphragmatic Breathing Exercise, Volume and Flow Incentive Spirometry, on Diaphragm Excursion and Pulmonary Function in Patients Undergoing Laparoscopic Surgery: A Randomized Controlled Trial

    Directory of Open Access Journals (Sweden)

    Gopala Krishna Alaparthi

    2016-01-01

    Full Text Available Objective. To evaluate the effects of diaphragmatic breathing exercises and flow and volume-oriented incentive spirometry on pulmonary function and diaphragm excursion in patients undergoing laparoscopic abdominal surgery. Methodology. We selected 260 patients posted for laparoscopic abdominal surgery and they were block randomization as follows: 65 patients performed diaphragmatic breathing exercises, 65 patients performed flow incentive spirometry, 65 patients performed volume incentive spirometry, and 65 patients participated as a control group. All of them underwent evaluation of pulmonary function with measurement of Forced Vital Capacity (FVC, Forced Expiratory Volume in the first second (FEV1, Peak Expiratory Flow Rate (PEFR, and diaphragm excursion measurement by ultrasonography before the operation and on the first and second postoperative days. With the level of significance set at p<0.05. Results. Pulmonary function and diaphragm excursion showed a significant decrease on the first postoperative day in all four groups (p<0.001 but was evident more in the control group than in the experimental groups. On the second postoperative day pulmonary function (Forced Vital Capacity and diaphragm excursion were found to be better preserved in volume incentive spirometry and diaphragmatic breathing exercise group than in the flow incentive spirometry group and the control group. Pulmonary function (Forced Vital Capacity and diaphragm excursion showed statistically significant differences between volume incentive spirometry and diaphragmatic breathing exercise group (p<0.05 as compared to that flow incentive spirometry group and the control group. Conclusion. Volume incentive spirometry and diaphragmatic breathing exercise can be recommended as an intervention for all patients pre- and postoperatively, over flow-oriented incentive spirometry for the generation and sustenance of pulmonary function and diaphragm excursion in the management of

  18. Comparison of the effects of antihypertensive agents on central blood pressure and arterial stiffness in isolated systolic hypertension.

    Science.gov (United States)

    Mackenzie, Isla S; McEniery, Carmel M; Dhakam, Zahid; Brown, Morris J; Cockcroft, John R; Wilkinson, Ian B

    2009-08-01

    Isolated systolic hypertension is an important risk factor for cardiovascular disease and results primarily from elastic artery stiffening. Although various drug therapies are used to lower peripheral blood pressure (BP) in patients with isolated systolic hypertension, the effects of the 4 major classes of antihypertensive agents on central BP, pulse pressure (PP) amplification, and arterial stiffness in this condition are not clear. Fifty-nine patients over the age of 60 years with untreated isolated systolic hypertension (systolic BP > or =140 mm Hg and diastolic BP hypertension, the choice of therapy may be influenced by these findings in the future.

  19. Assessment of Left Ventricular Longitudinal Regional Myocardial Systolic Function by Strain Imaging Echocardiography in Patients with Hypertrophic Cardiomyopathy

    Institute of Scientific and Technical Information of China (English)

    LIU Yani; DENG Youbin; LI Xiulan; CHANG Qing; LU Yongping; LI Chunlei

    2005-01-01

    To assess the left ventricular longitudinal regional myocardial systolic function by strain imaging (SI) echocardiography and to study the relationship between regional myocardial systolic function and left ventricular structure in patients with hypertrophic cardiomyopathy (HCM). SI echocardiography were performed in 18 patients with HCM and 17 healthy subjects. For each wall,regional myocardial systolic strain was analyzed at the basal, mid, and apical level respectively.And the peak systolic strain was measured. Our results showed that the patients with HCM had reduced peak systolic strain at almost each segment of different walls when compared with healthy subjects. There was significant correlation between the mid-septum peak systolic strain and the thickness of IVS, so was the correlation between the mid-septum peak systolic strain and the IVS to LVPW thickness ratio. This study demonstrated that the left ventricular longitudinal regional myocardial systolic function was abnormal in HCM, and this kind of abnormalities existed extensively in hypertrophic and non-hypertrophic cardiac segments. The degrees of left ventricle hypertrophy and asymmetry are related to the myocardial regional systolic function in HCM.

  20. The Mono Lake geomagnetic excursion recorded in loess: Its application as time marker and implications for its geomagnetic nature

    Science.gov (United States)

    Hambach, U.; Hark, M.; Zeeden, C.; Reddersen, B.; Zöller, L.; Fuchs, M.

    2009-04-01

    One of the youngest and worldwide documented geomagnetic excursions in the Brunhes Chron is the Mono Lake excursion (MLE). It has been detected in marine and terrestrial sedimentary archives as well as in lavas. Recent age determinations and age estimates for the MLE centre around an age interval of approximately 31 - 34 ka. Likewise the Laschamp excursion the MLE goes along with a distinct peak in cosmogenic radionuclides in ice cores and sedimentary archives. It provides therefore an additional geomagnetic time marker for various geoarchives to synchronise different climate archives. Here we report on a detailed record of the MLE from a loess site at Krems, Lower Austria. The site is situated on the southern slope of the Wachtberg hill in the vicinity of the old city centre of Krems. The archive comprises Middle to Upper Würmian (Late Pleistocene) loess in which an Upper Palaeolithic (Early Gravettian) cultural layer is embedded. The most spectacular finds are a double infant burial found in 2005 and a single burial discovered in 2006 (Einwögerer et al., 2006). Generally, archaeological findings show an extraordinarily good preservation due to embedding in rapidly sedimented loess (Händel et al., 2008). The about 10 m thick loess pile consists of calcareous sandy, coarse silt which is rich in mica indicating local sources. It is well stratified with brownish horizons representing embryonic soils pointing to incipient pedogenesis. Some of the pedo-horizons show occasionally indications of minor erosion and bedding-parallel sediment transport, but no linear erosional features. Pale greyish horizons are the result of partial gleying under permafrost conditions. No strong pedogenesis including decalcification and clay formation is present. The cultural layer is still covered by more than 5 m of loess, and dated by radiocarbon to ~27 ka 14C BP (Einwögerer et al., 2006). Below this layer up to 2.5 m of loess resting on Lower Pleistocene fluvial gravels are

  1. Feller-Brown 运动的游程与 Tanaka 公式%Excursions and Tananka Formula of Feller-Brownian Motions

    Institute of Scientific and Technical Information of China (English)

    杜海霞; 谢栋梁; 李永凤

    2013-01-01

    The excursion theory of Feller-Brownian motions about the state of 0 was discussed.All the Feller-Brownian motions were structured by using the excursion theory and the Tanaka formula of this kind of processes were given.%  讨论了 Feller-Brown 运动关于状态0的游程理论,利用游程理论构造了所有的 Feller-Brown 运动,并给出了这类过程的 Tanaka 公式。

  2. An economic evaluation of rosuvastatin treatment in systolic heart failure : evidence from the CORONA trial

    NARCIS (Netherlands)

    Lorgelly, Paula K.; Briggs, Andrew H.; Wedel, Hans; Dunselman, Peter; Hjalmarson, Ake; Kjekshus, John; Waagstein, Finn; Wikstrand, John; Janosi, Andras; van Veldhuisen, Dirk J.; Barrios, Vivencio; Fonseca, Candida; McMurray, John J. V.

    2010-01-01

    To estimate the cost-effectiveness of 10 mg rosuvastatin daily for older patients with systolic heart failure in the Controlled Rosuvastatin Multinational Study in Heart Failure (CORONA) trial. This within trial analysis of CORONA used major cardiovascular (CV) events as the outcome measure. Resourc

  3. Study on Left Ventricular Diastolic Function under Different Left Ventricular Systolic Function

    Institute of Scientific and Technical Information of China (English)

    刘金来; SAID Mohmmed Abdalla; 王庆慧; 张成喜; 陈璘; 张燕玉

    2002-01-01

    Objectives Assessment of diastolic function is vital to impart information relevant to patients' cardiac functional class, diagnosis and management. We sought to investigate diastolic function under normal systolic function and systolic dysfunction and pseudonormalized phenomena.Methods 36 normal subjects( Group Ⅰ), 33 patients with coronary artery disease(CAD) (Group Ⅱ) and 74patients with essential hypertension(EH) (Group Ⅲ)were studied by color M-mode Doppler echocardiogrphy. The rate of propagation of peak early filling flowvelocity(Vp), time delay(TD) of the peak early fillingflow velocity from mitral tips to the apex, Vp/E andother parameters were measured by color M-modeDoppler echocardiography. Results Three groups had no statistical differences in gender, age and heart rate. There were significant differences of Vp, TD and Vp/E ratio between systolic dysfunction group and normal systolic function group. The result also showed significant differences in Vp, TD and Vp/E between pseudonormal group and control group( P < 0.01Conclusion The rate and time of propagation of peak early filling flow velocity (Vp, TD, Vp/E) by M -mode color Doppler echocardiography are more precise and reliable parameters to evaluate LV diastolic function by distinguishing pseudonormalized transmitral flow pattern.

  4. Effect of preload alternations on a new Doppler echocardiographic index of combined systolic and diastolic performance

    DEFF Research Database (Denmark)

    Møller, J E; Poulsen, S H; Egstrup, K

    1999-01-01

    The objective of the study was to assess the effect of preload alternations on a nongeometric Doppler index of combined systolic and diastolic myocardial performance (MPI). Doppler echocardiography was performed during Valsalva maneuver, passive leg lifting, and after sublingual administration of...

  5. Current Evidence on Treatment of Patients With Chronic Systolic Heart Failure and Renal Insufficiency

    NARCIS (Netherlands)

    Damman, Kevin; Tang, W. H. Wilson; Felker, G. Michael; Lassus, Johan; Zannad, Faiez; Krum, Henry; McMurray, John J. V.

    2014-01-01

    Chronic kidney disease (CKD) is increasingly prevalent in patients with chronic systolic heart failure. Therefore, evidence-based therapies are more and more being used in patients with some degree of renal dysfunction. However, most pivotal randomized clinical trials specifically excluded patients

  6. Microalbuminuria in patients with non-insulin-dependent diabetes mellitus relates to nocturnal systolic blood pressure.

    LENUS (Irish Health Repository)

    Mitchell, T H

    2012-02-03

    PURPOSE: Microalbuminuria predicts early mortality in non-insulin-dependent-diabetes mellitus patients (NIDDM). Our objective in the present study was to compare and assess the relationship between 24-hour, day and nocturnal ambulatory blood pressure (BP) and urinary albumin excretion rate (UAE) in microalbuminuric and normoalbuminuric NIDDM and in normal control subjects. PATIENTS AND METHODS: In the present cross-sectional study, 24 hour ambulatory BP (daytime BP and nocturnal BP) and HbA1c were compared in microalbuminuric (n = 10) and nonmicroalbuminuric NIDDM patients (n = 10) and in nondiabetic controls (n = 9). None of the patients were taking antihypertensive agents. RESULTS: In the microlbuminuric group, whereas 24 hour and daytime systolic BP differed significantly from control values (P < 0.025 and P < 0.05 respectively), there was no difference between diabetic groups. However, nocturnal systolic BP in the microalbuminuric group was significantly higher than in the normoalbuminuric diabetic patients (139 vs. 125) (P < 0.05) and a significant difference was also found between the NIDDM patients and the control group (139, 125 vs. 114) (P < 0.025). In multiple regression analysis, only nocturnal systolic BP showed a significant relationship with UAE (P < 0.05). CONCLUSIONS: We suggest that the higher nocturnal systolic blood pressure seen in our microalbuminuric NIDDM patients may contribute to the increased morbidity in this group.

  7. Impact of Age on the Importance of Systolic and Diastolic Blood Pressures for Stroke Risk

    DEFF Research Database (Denmark)

    Vishram, Julie K K; Borglykke, Anders; Andreasen, Anne H;

    2012-01-01

    This study investigates age-related shifts in the relative importance of systolic (SBP) and diastolic (DBP) blood pressures as predictors of stroke and whether these relations are influenced by other cardiovascular risk factors. Using 34 European cohorts from the MOnica, Risk, Genetics, Archiving...

  8. Systolic blood pressure reactivity during submaximal exercise and acute psychological stress in youth

    Science.gov (United States)

    Background: Studies in youth show an association between systolic blood-pressure (SBP) reactivity to acute psychological stress and carotid artery intima-media thickness (CIMT). However, it has not yet been determined whether SBP reactivity during submaximal exercise is also associated with CIMT i...

  9. Systolically gated 3D phase contrast MRA of mesenteric arteries in suspected mesenteric ischemia

    Energy Technology Data Exchange (ETDEWEB)

    Wasser, M.N.; Schultze Kool, L.J.; Roos, A. de [Leiden Univ. Hospital (Netherlands)] [and others

    1996-03-01

    Our goal was to assess the value of MRA for detecting stenoses in the celiac (CA) and superior mesenteric (SMA) arteries in patients suspected of having chronic mesenteric ischemia, using an optimized systolically gated 3D phase contrast technique. In an initial study in 24 patients who underwent conventional angiography of the abdominal vessels for different clinical indications, a 3D phase contrast MRA technique (3D-PCA) was evaluated and optimized to image the CAs and SMAs. Subsequently, a prospective study was performed to assess the value of systolically gated 3D-PCA in evaluation of the mesenteric arteries in 10 patients with signs and symptoms of chronic mesenteric ischemia. Intraarterial digital subtraction angiography and surgical findings were used as the reference standard. In the initial study, systolic gating appeared to be essential in imaging the SMA on 3D-PCA. In 10 patients suspected of mesenteric ischemia, systolically gated 3D-PCA identified significant proximal disease in the two mesenteric vessels in 4 patients. These patients underwent successful reconstruction of their stenotic vessels. Cardiac-gated MRA may become a useful tool in selection of patients suspected of having mesenteric ischemia who may benefit from surgery. 16 refs., 6 figs., 4 tabs.

  10. Interarm differences in systolic blood pressure and mortality among US army veterans

    DEFF Research Database (Denmark)

    White, James; Mortensen, Laust Hvas; Kivimäki, Mika

    2014-01-01

    BACKGROUND: Differences between the arms in systolic blood pressure (SBP) of ≥10 mmHg have been associated with an increased risk of mortality in patients with hypertensive and chronic renal disease. For the first time, we examined these relationships in a non-clinical population. DESIGN: Cohort ...

  11. Systolic left ventricular function according to left ventricular concentricity and dilatation in hypertensive patients

    DEFF Research Database (Denmark)

    Bang, Casper; Gerdts, Eva; Aurigemma, Gerard P;

    2013-01-01

    Left ventricular hypertrophy [LVH, high left ventricular mass (LVM)] is traditionally classified as concentric or eccentric based on left ventricular relative wall thickness. We evaluated left ventricular systolic function in a new four-group LVH classification based on left ventricular dilatatio...

  12. Functional and Hemodynamic Cardiac Determinants of Exercise Capacity in Patients With Systolic Heart Failure

    NARCIS (Netherlands)

    Hummel, Yoran M.; Bugatti, Silvia; Damman, Kevin; Willemsen, Suzan; Hartog, Jasper W. L.; Metra, Marco; Sipkens, Johannes S.; van Veldhuisen, Dirk J.; Voors, Adriaan A.

    2012-01-01

    Decreased exercise capacity is the main symptom in patients with heart failure (HF). We assessed the association among noninvasively determined maximal cardiac output at exercise, systolic and diastolic cardiac functions at rest, and peak oxygen uptake (pVO(2)) exercise capacity in patients with con

  13. Evaluation of echocardiographic systolic parameters in pre eclamptics and normotensives women

    Directory of Open Access Journals (Sweden)

    Neha Jain

    2015-10-01

    Conclusions: Systolic parameters get worsened in pre eclamptics. Early detection of change in these parameters could help to identify high risk women who are prone to develop cardiovascular morbidity in later life. [Int J Reprod Contracept Obstet Gynecol 2015; 4(5.000: 1517-1521

  14. Impaired Systolic Function by Strain Imaging in Heart Failure With Preserved Ejection Fraction

    NARCIS (Netherlands)

    Kraigher-Krainer, Elisabeth; Shah, Amil M.; Gupta, Deepak K.; Santos, Angela; Claggett, Brian; Pieske, Burkert; Zile, Michael R.; Voors, Adriaan A.; Lefkowitz, Marty P.; Packer, Milton; McMurray, John J. V.; Solomon, Scott D.

    2014-01-01

    Objectives This study sought to determine the frequency and magnitude of impaired systolic deformation in heart failure with preserved ejection fraction (HFpEF). Background Although diastolic dysfunction is widely considered a key pathophysiologic mediator of HFpEF, the prevalence of concomitant sys

  15. Isolated systolic hypertension in an elderly Danish population. Prevalence and daytime ambulatory blood pressure

    DEFF Research Database (Denmark)

    Talleruphuus, Ulrik; Bang, Lia Evi; Wiinberg, Niels;

    2006-01-01

    Isolated systolic hypertension (ISH) is a major risk factor for cardiovascular complications. Nevertheless, data on the prevalence in a representative population do not seem to be available. The prevalence of ISH and the white coat effect was thus studied in a cross-sectional survey of 2806 inhab...

  16. Assessment of right ventricular systolic function by echocardiography after surgical repair of congenital heart defects.

    Science.gov (United States)

    Khraiche, Diala; Ben Moussa, Nidhal

    2016-02-01

    Postoperative impairment of right ventricular (RV) systolic function can appear after surgical repair of complex congenital heart defects, such as tetralogy of Fallot; it is caused by chronic volume and/or pressure overload due to pulmonary regurgitation and/or stenosis. RV dysfunction is strongly associated with prognosis in these patients. Cardiac magnetic resonance imaging is the gold standard for quantification of RV volumes and ejection fraction in patients with congenital heart diseases; however, it is costly and is not widely available. Echocardiography is the imaging modality that is most available and most frequently used to assess RV systolic function. However, RV ejection fraction cannot be measured accurately by standard two-dimensional echocardiography because of its pyramidal shape. Surrogate parameters of RV systolic function are mostly used in routine practice. New techniques of two-dimensional strain and three-dimensional quantification of RV volumes and ejection fraction have been developed in recent years. The aim of this article is to show the pertinence of each variable of RV systolic function measured by echocardiography in patients with repaired congenital heart disease and residual chronic RV overload.

  17. Dairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study

    Science.gov (United States)

    This study examined whether previous observed inverse associations of dairy intake with systolic blood pressure and risk of hypertension were causal. A Mendelian randomization study was employed, using the single nucleotide polymorphism rs4988235 related to lactase persistence as an instrumental var...

  18. The measurement of digital systolic blood pressure by strain gauge technique

    DEFF Research Database (Denmark)

    Nielsen, P E; Bell, G; Lassen, N A

    1972-01-01

    The systolic blood pressure on the finger, toe, and ankle has been measured by a strain gauge technique in 10 normal subjects aged 17-31 years and 14 normal subjects aged 43-57 years. The standard deviation in repeated measurements lies between 2 and 6 mm Hg. The finger pressure in the younger...

  19. Prognostic utility of blood pressure-adjusted global and basal systolic longitudinal strain

    Directory of Open Access Journals (Sweden)

    Isaac B Rhea

    2016-05-01

    Full Text Available Assessment of global longitudinal systolic strain (GLS and longitudinal systolic strain of the basal segments (BLS has shown prognostic value in cardiac disorders. However, strain is reduced with increased afterload. We assessed the prognostic value of GLS and BLS adjusted for afterload. GLS and BLS were determined in 272 subjects with normal ejection fraction and no known coronary disease, or significant valve disease. Systolic blood pressure (SP and diastolic blood pressure (DP obtained at the time of echocardiography were used to adjust GLS and BLS as follows: strain × SP (mmHg/120 mmHg and strain × DP (mmHg/80 mmHg. Patients were followed for cardiac events and mortality. The mean age was 53 ± 15 years and 53% had hypertension. There were 19 cardiac events and 70 deaths over a mean follow-up of 26 ± 14 months. Cox analysis showed that left ventricular mass index (P = 0.001, BLS (P < 0.001, and DP-adjusted BLS (P < 0.001 were independent predictors of cardiac events. DP-adjusted BLS added incremental value (P < 0.001 to the other two predictors and had an area under the curve of 0.838 for events. DP (P = 0.001, age (P = 0.001, ACE inhibitor use (P = 0.017, and SP-adjusted BLS (P = 0.012 were independent predictors of mortality. SP-adjusted BLS added incremental value (P = 0.014 to the other independent predictors. In conclusion, DP-adjusted BLS and SP-adjusted BLS were independent predictors of cardiac events and mortality, respectively. Blood pressure-adjusted strain added incremental prognostic value to other predictors of outcome. Introduction Assessment of global longitudinal systolic strain (GLS and basal longitudinal systolic strain (BLS have shown utility for prediction of prognosis in various cardiac disorders (1, 2, 3, 4. In some studies, longitudinal strain has been shown to be a more sensitive indicator of left ventricular (LV systolic dysfunction than traditional measures of function (5, 6. The detection of early

  20. CHANGES IN CARDIAC STATUS DUE TO ISOLATED SYSTOLIC HYPERTENSION BY NON - INVASIVE STUDIES

    Directory of Open Access Journals (Sweden)

    Sourangsu

    2014-01-01

    Full Text Available AIM : It was thought previously that morbidity and mortality are directly related to both Systolic and Diastolic blood pressure . However evidences from different studies suggest that systolic hypertension deserves more importance especially due to its profound effect on cardiovascular disease progression. Isolated systolic hypertension (ISH has now increased amongst the elderly population due to inc reased longevity. METHOD : Total 240 patients of 65 – 89 years age group were taken as study group at the out - patient and in - door department of CNMC Kolkata and NBMC , Siliguri. All patients were divided into three groups based on systolic blood pressure : Gr A=SBP - 140 — 159 mmHg , Gr B=SBP - 160 - 179 mmHg & Gr C=SBP>180 mmHg with each group having age and sex matched 100 healthy normotensive control subjects. History , Clinical examination , ECG and Echocardiographic studies were done in the selected patients . Sop histicated tests were not done due to nonavailability. RESULTS : Major Electrocardiogram changes are left atrial enlargement , left ventricular hypertrophy with systolic strain , Inferior wall ischemia , both bundle branch blocks , bifascicular block , left axis deviation. Other minor changes were : antero - septal ischemia , septal wall ischemia , lateral wallischemia , right axis deviation , arrhythmia , and low voltage were also noted. Echocardiography in 2 - D and M - ModeandEcho - Doppler assessment showed incre ased Intraventricular septal thickness (IVST , Left ventricular posterior wall Thickness (LVPWT and Left ventricular mass index were the major changes. Left ventricular functional abnormality like diastolic dysfunction was another significant abnormality. CONCLUSION : Different anatomical & functional changes in ISH are more prevalent in higher SBP group , and strong risk factor for future catastrophic cardiac events. It is an independent risk factor for CVS morbidity and mortality. Early therapeutic interve ntion

  1. Repeated heart rate measurement and cardiovascular outcomes in left ventricular systolic dysfunction.

    Science.gov (United States)

    Hamill, Victoria; Ford, Ian; Fox, Kim; Böhm, Michael; Borer, Jeffrey S; Ferrari, Roberto; Komajda, Michel; Steg, Philippe Gabriel; Tavazzi, Luigi; Tendera, Michal; Swedberg, Karl

    2015-10-01

    Elevated resting heart rate is associated with increased cardiovascular risk, particularly in patients with left ventricular systolic dysfunction. Heart rate is not monitored routinely in these patients. We hypothesized that routine monitoring of heart rate would increase its prognostic value in patients with left ventricular systolic dysfunction. We analyzed the relationship between heart rate measurements and a range of adverse cardiovascular outcomes, including hospitalization for worsening heart failure, in the pooled placebo-treated patients from the morBidity-mortality EvAlUaTion of the If inhibitor ivabradine in patients with coronary disease and left ventricULar dysfunction (BEAUTIFUL) trial and Systolic Heart failure treatment with the If inhibitor ivabradine (SHIFT) Trial, using standard and time-varying covariate Cox proportional hazards models. By adjusting for other prognostic factors, models were fitted for baseline heart rate alone or for time-updated heart rate (latest heart rate) alone or corrected for baseline heart rate or for immediate previous time-updated heart rate. Baseline heart rate was strongly associated with all outcomes apart from hospitalization for myocardial infarction. Time-updated heart rate increased the strengths of associations for all outcomes. Adjustment for baseline heart rate or immediate previous time-updated heart rate modestly reduced the prognostic importance of time-updated heart rate. For hospitalization for worsening heart failure, each 5 beats/min increase in baseline heart rate and time-updated heart rate was associated with a 15% (95% confidence interval, 12-18) and 22% (confidence interval, 19-40) increase in risk, respectively. Even after correction, the prognostic value of time-updated heart rate remained greater. In patients with left ventricular systolic dysfunction, time-updated heart rate is more strongly related with adverse cardiovascular outcomes than baseline heart rate. Heart rate should be measured to

  2. Characteristic systolic waveform of left ventricular longitudinal strain rate in patients with hypertrophic cardiomyopathy.

    Science.gov (United States)

    Okada, Kazunori; Kaga, Sanae; Mikami, Taisei; Masauzi, Nobuo; Abe, Ayumu; Nakabachi, Masahiro; Yokoyama, Shinobu; Nishino, Hisao; Ichikawa, Ayako; Nishida, Mutsumi; Murai, Daisuke; Hayashi, Taichi; Shimizu, Chikara; Iwano, Hiroyuki; Yamada, Satoshi; Tsutsui, Hiroyuki

    2016-10-18

    We analyzed the waveform of systolic strain and strain-rate curves to find a characteristic left ventricular (LV) myocardial contraction pattern in patients with hypertrophic cardiomyopathy (HCM), and evaluated the utility of these parameters for the differentiation of HCM and LV hypertrophy secondary to hypertension (HT). From global strain and strain-rate curves in the longitudinal and circumferential directions, the time from mitral valve closure to the peak strains (T-LS and T-CS, respectively) and the peak systolic strain rates (T-LSSR and T-CSSR, respectively) were measured in 34 patients with HCM, 30 patients with HT, and 25 control subjects. The systolic strain-rate waveform was classified into 3 patterns ("V", "W", and "√" pattern). In the HCM group, T-LS was prolonged, but T-LSSR was shortened; consequently, T-LSSR/T-LS ratio was distinctly lower than in the HT and control groups. The "√" pattern of longitudinal strain-rate waveform was more frequently seen in the HCM group (74 %) than in the control (4 %) and HT (20 %) groups. Similar but less distinct results were obtained in the circumferential direction. To differentiate HCM from HT, the sensitivity and specificity of the T-LSSR/T-LS ratio waveform were 85 and 63 %, and 74 and 80 %, respectively. In conclusion, in patients with HCM, a reduced T-LSSR/T-LS ratio and a characteristic "√"-shaped waveform of LV systolic strain rate was seen, especially in the longitudinal direction. The timing and waveform analyses of systolic strain rate may be useful to distinguish between HCM and HT.

  3. Slipping and Rolling on an Inclined Plane

    Science.gov (United States)

    Aghamohammadi, Cina; Aghamohammadi, Amir

    2011-01-01

    In the first part of the paper, using a direct calculation two-dimensional motion of a particle sliding on an inclined plane is investigated for general values of friction coefficient ([mu]). A parametric equation for the trajectory of the particle is also obtained. In the second part of the paper, the motion of a sphere on the inclined plane is…

  4. The European Galactic Plane Surveys: EGAPS

    NARCIS (Netherlands)

    Groot, P.J.; Drew, J.; Greimel, R.; Gaensicke, B.; Knigge, C.; Irwin, M.; Mampaso, A.; Augusteijn, T.; Morales-Rueda, L.; Barlow, M.; Iphas, C.; Uvex, C.; Vphas, C.

    2006-01-01

    Introduction: The European Galactic Plane Surveys (EGAPS) will for the first time ever map the complete galactic plane (10x360 degrees) down to 21st magnitude in u', g', r', i' and H-alpha and partly in He I 5875. It will complete a database of ~1 billion objects. The aim of EGAPS is to study popula

  5. Fast & Furious focal-plane wavefront sensing

    NARCIS (Netherlands)

    Korkiakoski, V.A.; Keller, C.U.; Doelman, N.; Kenworthy, M.; Otten, G.; Verhaegen, M.H.G.

    2014-01-01

    We present two complementary algorithms suitable for using focal-plane measurements to control a wavefront corrector with an extremely high-spatial resolution. The algorithms use linear approximations to iteratively minimize the aberrations seen by the focal-plane camera. The first algorithm, Fast &

  6. Focal-plane sensor-processor chips

    CERN Document Server

    Zarándy, Ákos

    2011-01-01

    Focal-Plane Sensor-Processor Chips explores both the implementation and application of state-of-the-art vision chips. Presenting an overview of focal plane chip technology, the text discusses smart imagers and cellular wave computers, along with numerous examples of current vision chips.

  7. Development of Technique to Detect and Classify Small-Scale Magnetic Flux Cancellation and Rapid Blueshifted Excursions

    CERN Document Server

    Chen, Xin; Lamb, Derek A; Jing, Ju; Liu, Chang; Liu, Rui; Park, Sung-Hong; Wang, Haimin

    2015-01-01

    We present a set of tools for detecting small-scale solar magnetic cancellations and the disk counterpart of type II spicules (the so-called Rapid Blueshifted Excursions (RBEs)), using line-of-sight photospheric magnetograms and chromospheric spectroscopic observations, respectively. For tracking magnetic cancellation, we improve the Southwest Automatic Magnetic Identification Suite (SWAMIS) so that it is able to detect certain obscure cancellations that can be easily missed. For detecting RBEs, we use a normalized reference profile to reduce false-positive detections caused by the non-uniform background and seeing condition. Similar to the magnetic feature tracking in SWAMIS, we apply a dual-threshold method to enhance the accuracy of RBE detection. These tools are employed to analyze our coordinated observations using the Interferometric BIdimensional Spectrometer at Dunn Solar Telescope (DST) of the National Solar Observatory (NSO) and Hinode. We present the statistical properties of magnetic cancellations...

  8. The limiting distribution of the maximal height of the outermost path of nonintersecting Brownian excursions and discrete Gaussian orthogonal polynomials

    CERN Document Server

    Liechty, Karl

    2011-01-01

    We study the distribution of the maximal height of the outermost path in the model of $N$ nonintersecting Brownian excursions as $N\\to \\infty$, showing that it converges in the proper scaling to the Tracy-Widom distribution for the largest eigenvalue of the Gaussian orthogonal ensemble. This is as expected from the viewpoint that the maximal height of the outermost path converges to the maximum of the Airy process. Our proof is based on Riemann-Hilbert analyis of a system of discrete orthogonal polynomials with a Gaussian weight in the double scaling limit as this system approaches saturation. We consequently compute the asymptotics of the free energy and the reproducing kernel of the corresponding discrete orthogonal polynomial ensemble in the critical scaling in which the density of particles approaches saturation. Both of these results can be viewed as dual to the case in which the mean density of eigenvalues in a random matrix model is vanishing at one point.

  9. Early Eocene carbon isotope excursions: Evidence from the terrestrial coal seam in the Fushun Basin, Northeast China

    Science.gov (United States)

    Chen, Zuoling; Ding, Zhongli; Tang, Zihua; Wang, Xu; Yang, Shiling

    2014-05-01

    A series of transient global warming events between 56 and 50 Ma are characterized by a pronounced negative carbon isotope excursion (CIE). However, the documents of these hyperthermals, such as Eocene Thermal Maximum 2 and H2 events, have come chiefly from marine sediments, and their expression in terrestrial organic carbon is still poorly constrained. Here we yield a high-resolution carbon isotope record of terrestrial organic material from the Fushun Basin, which displays four prominent CIEs with magnitudes larger than 2.5‰. Based on age constraint and comparisons with deep-sea records, our data provide the first evidence of the four hyperthermals in coal seams and suggest a global significance of these events. Moreover, the difference of CIE magnitudes between marine and terrestrial records shows a significant linear correlation with the marine carbonate CIE, implying that these events are likely attributable to recurring injections of 13C-depleted carbon from submarine methane hydrates and/or permafrost.

  10. Testing Postural Stability: Are the Star Excursion Balance Test and Biodex Balance System Limits of Stability Tests Consistent?

    Science.gov (United States)

    Glave, A Page; Didier, Jennifer J; Weatherwax, Jacqueline; Browning, Sarah J; Fiaud, Vanessa

    2016-01-01

    There are a variety of options to test postural stability; however many physical tests lack validity information. Two tests of postural stability - the Star Excursion Balance Test (SEBT) and Biodex Balance System Limits of Stability Test (LOS) - were examined to determine if similar components of balance were measured. Healthy adults (n=31) completed the LOS (levels 6 and 12) and SEBT (both legs). SEBT directions were offset by 180° to approximate LOS direction. Correlations and partial correlations controlling for height were analyzed. Correlations were significant for SEBT 45° and LOS back-left (6: r=-0.41; 12: r=-0.42; pbalance. Research is needed to determine and define what specific components of balance are being assessed. Care must be taken when choosing balance tests to best match the test to the purpose of testing (fall risk, athletic performance, etc.).

  11. Slipping and rolling on an inclined plane

    Energy Technology Data Exchange (ETDEWEB)

    Aghamohammadi, Cina [Department of Electrical Engineering, Sharif University of Technology, PO Box 11365-11155, Tehran (Iran, Islamic Republic of); Aghamohammadi, Amir, E-mail: mohamadi@alzahra.ac.ir [Department of Physics, Alzahra University, Tehran 19938-91176 (Iran, Islamic Republic of)

    2011-07-15

    In the first part of the paper, using a direct calculation two-dimensional motion of a particle sliding on an inclined plane is investigated for general values of friction coefficient ({mu}). A parametric equation for the trajectory of the particle is also obtained. In the second part of the paper, the motion of a sphere on the inclined plane is studied. It is shown that the evolution equation for the contact point of a sliding sphere is similar to that of a point particle sliding on an inclined plane whose friction coefficient is 7/2 {mu}. If {mu} > 2/7 tan {theta}, for any arbitrary initial velocity and angular velocity, the sphere will roll on the inclined plane after some finite time. In other cases, it will slip on the inclined plane. In the case of rolling, the centre of the sphere moves on a parabola. Finally the velocity and angular velocity of the sphere are exactly computed.

  12. Slipping and Rolling on an Inclined Plane

    CERN Document Server

    Aghamohammadi, Cina; 10.1088/0143-0807/32/4/017

    2011-01-01

    In the first part of the article using a direct calculation two-dimensional motion of a particle sliding on an inclined plane is investigated for general values of friction coefficient ($\\mu$). A parametric equation for the trajectory of the particle is also obtained. In the second part of the article the motion of a sphere on the inclined plane is studied. It is shown that the evolution equation for the contact point of a sliding sphere is similar to that of a point particle sliding on an inclined plane whose friction coefficient is $2/7}\\ \\mu$. If $\\mu> 2/7 \\tan\\theta$, for any arbitrary initial velocity and angular velocity the sphere will roll on the inclined plane after some finite time. In other cases, it will slip on the inclined plane. In the case of rolling center of the sphere moves on a parabola. Finally the velocity and angular velocity of the sphere are exactly computed.

  13. Heat transfer in fish: are short excursions between habitats a thermoregulatory behaviour to exploit resources in an unfavourable thermal environment?

    Science.gov (United States)

    Pépino, Marc; Goyer, Katerine; Magnan, Pierre

    2015-11-01

    Temperature is the primary environmental factor affecting physiological processes in ectotherms. Heat-transfer models describe how the fish's internal temperature responds to a fluctuating thermal environment. Specifically, the rate coefficient (k), defined as the instantaneous rate of change in body temperature in relation to the difference between ambient and body temperature, summarizes the combined effects of direct thermal conduction through body mass, passive convection (intracellular and intercellular fluids) and forced convective heat transfer (cardiovascular system). The k-coefficient is widely used in fish ecology to understand how body temperature responds to changes in water temperature. The main objective of this study was to estimate the k-coefficient of brook charr equipped with internal temperature-sensitive transmitters in controlled laboratory experiments. Fish were first transferred from acclimation tanks (10°C) to tanks at 14, 19 or 23°C (warming experiments) and were then returned to the acclimation tanks (10°C; cooling experiments), thus producing six step changes in ambient temperature. We used non-linear mixed models to estimate the k-coefficient. Model comparisons indicated that the model incorporating the k-coefficient as a function of absolute temperature difference (dT: 4, 9 and 13°C) best described body temperature change. By simulating body temperature in a heterogeneous thermal environment, we provide theoretical predictions of maximum excursion duration between feeding and resting areas. Our simulations suggest that short (i.e. <60 min) excursions could be a common thermoregulatory behaviour adopted by cold freshwater fish species to sustain body temperature below a critical temperature threshold, enabling them to exploit resources in an unfavourable thermal environment. © 2015. Published by The Company of Biologists Ltd.

  14. The Termination and Aftermath of the Lomagundi-Jatuli Carbon Isotope Excursions in the Paleoproterozoic Hutuo Group, North China

    Institute of Scientific and Technical Information of China (English)

    Zhenbing She; Fanyan Yang; Wei Liu; Luhua Xie; Yusheng Wan; Chao Li; Dominic Papineau

    2016-01-01

    ABSTRACT:The Lomagundi-Jatuli Event (LJE) is one of the largest and earliest positive carbon iso-tope excursions preserving δ13Ccarb values between +5 and +16‰ in Paleoproterozoic carbonates worldwide. However, the duration, amplitude and patterns of these excursions remain poorly con-strained. The 2.14–1.83 Ga Hutuo Group in the North China Craton is a >10 km thick volca-no-sedimentary sequence, including>5 km thick well-preserved carbonates that were deposited in su-pra-tidal to sub-tidal environments. C-O isotopic and elemental analyses of 152 least altered samples of the carbonates revealed a three-stageδ13C evolution. It began with an exclusively positiveδ13Ccarb (+1.3 to+3.4‰) stage in the~2.1 Ga carbonate in the Dashiling and Qingshicun Formations, followed by a transition from positive values to oscillating positive and negative values in~3 000 m thick carbonates of the Wenshan, Hebiancun, Jianancun, and Daguandong Formations, and end with exclusively nega-tiveδ13Ccarb values preserved in>500 m thick dolostones of the Huaiyincun and Beidaxing Formations. It appears that much of the LJE, particularly those extremely positiveδ13Ccarb signals, was not recorded in the Hutuo carbonates. The exclusively positiveδ13Ccarb values (+1.3 to+3.4‰) preserved in the lower formations likely correspond to the end of the LJE, whereas the subsequent two stages reflect the af-termath of the LJE and the onset of Shunga-Francevillian event (SFE). The present data point to an increased influence of oxygen on the carbon cycle from the Doucun to the Dongye Subgroups and demonstrate that the termination of the LJE in the North China Craton is nearly simultaneous with those in Fennoscandia and South Africa.

  15. Greater postprandial glucose excursions and inadequate nutrient intake in youth with type 1 diabetes and celiac disease

    Science.gov (United States)

    Pham-Short, Anna; Donaghue, Kim C; Ambler, Geoffrey; Garnett, Sarah; Craig, Maria E.

    2017-01-01

    The gluten free diet (GFD) has a high glycemic index and low-fiber content, which potentially influences glycemic excursions in type 1 diabetes (T1D) and celiac disease (CD). Participants in this case-control study of youth with T1D+CD (n = 10) and T1D only (n = 7) wore blinded continuous glucose monitoring systems for six days. Blood glucose levels (BGLs) were compared between groups for each meal, including pre-meal, peak, 2-hour postprandial and time-to-peak. Participants consumed a test-breakfast of GF cereal and milk for three days and kept weighed food diaries; nutrient intake was analyzed and compared to national recommendations. Youth with T1D+CD had shorter time-to-peak BGL (77 vs 89 mins, P = 0.03), higher peak (9.3 vs 7.3 mmol/L, P = 0.001) and higher postprandial BGLs than T1D (8.4 vs 7.0 mmol/L, P = 0.01), despite similar pre-meal BGLs (9.2 vs 8.6 mmol/L, P = 0.28). Regarding test breakfast, greater pre and post-meal BGL difference correlated with longer CD duration (R = 0.53, P = 0.01). Total energy and macronutrient intake didn’t differ between groups; however the majority of participants collectively had inadequate intake of calcium (76%), folate (71%) and fiber (53%), with excessive saturated fat (12%) and sodium (>2,000 mg/day). The GFD is associated with greater glycemic excursions and inadequate nutritional intake in youth with T1D+CD. Clinical management should address both glycemic variability and dietary quality. PMID:28338063

  16. Total flying hours and risk of high systolic blood pressure in the civilian pilot in Indonesia

    Directory of Open Access Journals (Sweden)

    Ferdi Afian

    2016-07-01

    Full Text Available Abstrak Latar belakang: Tekanan darah sistolik tinggi di antara pilot sipil antara lain akan menyebabkan gangguan kardiovaskular sehingga akan mengganggu kelancaran penerbangan. Tujuan penelitian ini ialah untuk mengetahui faktor-faktor dominan terhadap tekanan darah sistolik tinggi pada pilot sipil. Metode: Penelitian potong lintang dengan metode sampling purposif pada pilot yang melakukan pemeriksaan kesehatan berkala di Balai Kesehatan Penerbangan pada tanggal 18-29 Mei 2015. Data yang dikumpulkan adalah karakteristik demografi dan pekerjaan, klinis, kebiasaan olahraga, kebiasaan makan, indeks massa tubuh dan riwayat penyakit. Tekanan darah sistolik tinggi ialah tekanan darah sistolik140 mmHg atau lebih. Hasil: Dari 690 pilot yang melakukan pemeriksaan kesehatan berkala, 428 pilot laki-laki bersedia berpartisipasi mengikuti penelitian ini. Usia dan riwayat penyakit hipertensi merupakan faktor risiko dominan yang berhubungan dengan tekanan darah sistolik tinggi. Jika dibandingkan dengan pilot usia 19-39 tahun, yang berusia 40-65 tahun mempunyai 15,1 kali lipat lebih besar risiko terkena tekanan darah sistolik tinggi [rasio odds suaian (ORa= 15,12; p= 0,001]. Pilot dengan riwayat penyakit hipertensi dibandingkan dengan yang tidak ada riwayat memiliki risiko tekanan darah sistolik tinggi 93,2 kali lipat lebih besar (ORa= 93,21; p= 0,001 Kesimpulan: Usia 40-65 tahun dan memiliki riwayat hipertensi meningkatkan risiko tekanan darah sistolik tinggi di antara pilot sipil di Indonesia. Kata kunci: tekanan darah sistolik, total jam terbang, pilot sipil, Indonesia.  Abstract Background: Systolic high blood pressure among civilian pilots among others will cause cardiovascular disease and this condition will disrupt the flight.The purpose of this study was to identified the dominant factors related to high systolic blood pressure in the civilian pilots. Methods: A cross-sectional study with a purposive sampling method on a pilot who performed periodic

  17. Total flying hours and risk of high systolic blood pressure in the civilian pilot in Indonesia

    Directory of Open Access Journals (Sweden)

    Ferdi Afian

    2016-07-01

    Full Text Available Abstrak Latar belakang: Tekanan darah sistolik tinggi di antara pilot sipil antara lain akan menyebabkan gangguan kardiovaskular sehingga akan mengganggu kelancaran penerbangan. Tujuan penelitian ini ialah untuk mengetahui faktor-faktor dominan terhadap tekanan darah sistolik tinggi pada pilot sipil. Metode: Penelitian potong lintang dengan metode sampling purposif pada pilot yang melakukan pemeriksaan kesehatan berkala di Balai Kesehatan Penerbangan pada tanggal 18-29 Mei 2015. Data yang dikumpulkan adalah karakteristik demografi dan pekerjaan, klinis, kebiasaan olahraga, kebiasaan makan, indeks massa tubuh dan riwayat penyakit. Tekanan darah sistolik tinggi ialah tekanan darah sistolik140 mmHg atau lebih. Hasil: Dari 690 pilot yang melakukan pemeriksaan kesehatan berkala, 428 pilot laki-laki bersedia berpartisipasi mengikuti penelitian ini. Usia dan riwayat penyakit hipertensi merupakan faktor risiko dominan yang berhubungan dengan tekanan darah sistolik tinggi. Jika dibandingkan dengan pilot usia 19-39 tahun, yang berusia 40-65 tahun mempunyai 15,1 kali lipat lebih besar risiko terkena tekanan darah sistolik tinggi [rasio odds suaian (ORa= 15,12; p= 0,001]. Pilot dengan riwayat penyakit hipertensi dibandingkan dengan yang tidak ada riwayat memiliki risiko tekanan darah sistolik tinggi 93,2 kali lipat lebih besar (ORa= 93,21; p= 0,001 Kesimpulan: Usia 40-65 tahun dan memiliki riwayat hipertensi meningkatkan risiko tekanan darah sistolik tinggi di antara pilot sipil di Indonesia. Kata kunci: tekanan darah sistolik, total jam terbang, pilot sipil, Indonesia.  Abstract Background: Systolic high blood pressure among civilian pilots among others will cause cardiovascular disease and this condition will disrupt the flight.The purpose of this study was to identified the dominant factors related to high systolic blood pressure in the civilian pilots. Methods: A cross-sectional study with a purposive sampling method on a pilot who performed periodic

  18. Repeatability and Minimal Detectable Change in Longitudinal Median Nerve Excursion Measures During Upper Limb Neurodynamic Techniques in a Mixed Population: A Pilot Study Using Musculoskeletal Ultrasound Imaging.

    Science.gov (United States)

    Paquette, Philippe; Lamontagne, Martin; Higgins, Johanne; Gagnon, Dany H

    2015-07-01

    This study determined test-retest reliability and minimum detectable change in longitudinal median nerve excursion during upper limb neurodynamic tests (ULNTs). Seven participants with unilateral or bilateral carpal tunnel syndrome and 11 healthy participants were randomly tested with two ULNTs (i.e., tensioner and slider). Each ULNT was performed three times each at 45° and 90° of shoulder abduction on two separate visits. Video sequences of median nerve excursion, recorded by a physical therapist using ultrasound imaging, were quantified using computer software. The generalizability theory, encompassing a G-Study and a D-study, measured the dependability coefficient (Φ) along with standard error of measurement (SEM) accuracy and allowed various testing protocols to be proposed. The highest reliability (Φ = 0.84) and lowest minimal measurement error (SEM = 0.58 mm) of the longitudinal median nerve excursion were reached during the ULNT-slider performed with 45° of shoulder abduction and when measures obtained from three different image sequences recorded during a single visit were averaged. It is recommended that longitudinal median nerve excursion measures computed from three separate image sequences recorded during a single visit be averaged in clinical practice. Ideally, adding a second visit (six image sequences) is also suggested in research protocols.

  19. FUNCTIONAL-ANATOMY OF THE SOFT-TISSUES OF THE HAND AND WRIST - INVIVO EXCURSION MEASUREMENT OF THE FLEXOR POLLICIS LONGUS-TENDON USING MRI

    NARCIS (Netherlands)

    HAM, SJ; KONINGS, JG; WOLF, RFE; MOOYAART, EL

    1993-01-01

    Magnetic resonance imaging (MRI) of the flexor pollicis longus-tendon (FPL-tendon) with the thumb in different positions allows the in vivo assessment of its abduction-adduction/flexion excursion. Measurements can also be performed in different positions of the wrist. In our study, the mean

  20. FUNCTIONAL-ANATOMY OF THE SOFT-TISSUES OF THE HAND AND WRIST - INVIVO EXCURSION MEASUREMENT OF THE FLEXOR POLLICIS LONGUS-TENDON USING MRI

    NARCIS (Netherlands)

    HAM, SJ; KONINGS, JG; WOLF, RFE; MOOYAART, EL

    1993-01-01

    Magnetic resonance imaging (MRI) of the flexor pollicis longus-tendon (FPL-tendon) with the thumb in different positions allows the in vivo assessment of its abduction-adduction/flexion excursion. Measurements can also be performed in different positions of the wrist. In our study, the mean excursio

  1. Students' Long-Term Memories from an Ecology Field Excursion: Retelling a Narrative as an Interplay between Implicit and Explicit Memories

    Science.gov (United States)

    Stolpe, Karin; Bjorklund, Lars

    2013-01-01

    This study aims to investigate the science content remembered by biology students 6 and 12 months after an ecology excursion. The students' memories were tested during a stimulated recall interview. The authors identified three different types of memories: "recall," "recognition" and "narratives." The "dual…

  2. Correlations Between Echocardiographic Systolic and Diastolic Function with Cardiac Catheterization in Biventricular Congenital Heart Patients.

    Science.gov (United States)

    Nadorlik, H; Stiver, C; Khan, S; Miao, Y; Holzer, R; Cheatham, J P; Cua, C L

    2016-04-01

    Newer echocardiographic techniques may allow for more accurate assessment of left ventricular (LV) function. Adult studies have correlated these echocardiographic measurements with invasive data, but minimal data exist in the pediatric congenital heart population. Purpose of this study was to evaluate which echocardiographic measurements correlated best with LV systolic and diastolic catheterization parameters. Patients with two-ventricle physiology who underwent simultaneous echocardiogram and cardiac catheterization were included. Images were obtained in the four-chamber view. LV systolic echocardiographic data included ejection fraction, displacement, tissue Doppler imaging (TDI) s' wave, global longitudinal strain, and strain rate (SR) s' wave. Diastolic echocardiographic data included mitral E and A waves, TDI e' and a' waves, and SRe' and SRa' waves. E/TDI e', TDI e'/TDI a', E/SRe', and SRe'/SRa' ratios were also calculated. Catheterization dP/dt was used as a marker for systolic function, and LV end-diastolic pressure (EDP) was used as a marker for diastolic function. Correlations of the echocardiographic and catheterization values were performed using Pearson correlation. Twenty-nine patients were included (14 females, 15 males). Median age at catheterization was 3.4 years (0.04-17.4 years). dP/dt was 1258 ± 353 mmHg/s, and LVEDP was 10.8 ± 2.4 mmHg. There were no significant correlations between catheterization dP/dt and systolic echocardiographic parameters. LVEDP correlated significantly with SRe' (r = -0.4, p = 0.03), SRa' (r = -0.4, p = 0.03), and E/SRe' (r = 0.5, p = 0.004). In pediatric congenital heart patients, catheterization dP/dt did not correlate with echocardiographic measurements of LV systolic function. Further studies are needed to determine which echocardiographic parameter best describes LV systolic function in this population. Strain rate analysis significantly correlated with LVEDP. Strain rate analysis should be considered as an

  3. Dairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study.

    Science.gov (United States)

    Ding, Ming; Huang, Tao; Bergholdt, Helle Km; Nordestgaard, Børge G; Ellervik, Christina; Qi, Lu

    2017-03-16

    Objective To examine whether previous observed inverse associations of dairy intake with systolic blood pressure and risk of hypertension were causal.Design Mendelian randomization study using the single nucleotide polymorphism rs4988235 related to lactase persistence as an instrumental variable.Setting CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium.Participants Data from 22 studies with 171 213 participants, and an additional 10 published prospective studies with 26 119 participants included in the observational analysis.Main outcome measures The instrumental variable estimation was conducted using the ratio of coefficients approach. Using meta-analysis, an additional eight published randomized clinical trials on the association of dairy consumption with systolic blood pressure were summarized.Results Compared with the CC genotype (CC is associated with complete lactase deficiency), the CT/TT genotype (TT is associated with lactose persistence, and CT is associated with certain lactase deficiency) of LCT-13910 (lactase persistence gene) rs4988235 was associated with higher dairy consumption (0.23 (about 55 g/day), 95% confidence interval 0.17 to 0.29) serving/day; Pdairy consumption was not associated with systolic blood pressure (β=1.35, 95% confidence interval -0.28 to 2.97 mm Hg for each serving/day) or risk of hypertension (odds ratio 1.04, 0.88 to 1.24). Moreover, meta-analysis of the published clinical trials showed that higher dairy intake has no significant effect on change in systolic blood pressure for interventions over one month to 12 months (intervention compared with control groups: β=-0.21, 95% confidence interval -0.98 to 0.57 mm Hg). In observational analysis, each serving/day increase in dairy consumption was associated with -0.11 (95% confidence interval -0.20 to -0.02 mm Hg; P=0.02) lower systolic blood pressure but not risk of hypertension (odds ratio 0.98, 0.97 to 1.00; P=0.11).Conclusion

  4. Natriuretic peptide vs. clinical information for diagnosis of left ventricular systolic dysfunction in primary care

    Directory of Open Access Journals (Sweden)

    Wachter Rolf

    2008-02-01

    Full Text Available Abstract Background Screening of primary care patients at risk for left ventricular systolic dysfunction by a simple blood-test might reduce referral rates for echocardiography. Whether or not natriuretic peptide testing is a useful and cost-effective diagnostic instrument in primary care settings, however, is still a matter of debate. Methods N-terminal pro-brain natriuretic peptide (NT-proBNP levels, clinical information, and echocardiographic data of left ventricular systolic function were collected in 542 family practice patients with at least one cardiovascular risk factor. We determined the diagnostic power of the NT-proBNP assessment in ruling out left ventricular systolic dysfunction and compared it to a risk score derived from a logistic regression model of easily acquired clinical information. Results 23 of 542 patients showed left ventricular systolic dysfunction. Both NT-proBNP and the clinical risk score consisting of dyspnea at exertion and ankle swelling, coronary artery disease and diuretic treatment showed excellent diagnostic power for ruling out left ventricular systolic dysfunction. AUC of NT-proBNP was 0.83 (95% CI, 0.75 to 0.92 with a sensitivity of 0.91 (95% CI, 0.71 to 0.98 and a specificity of 0.46 (95% CI, 0.41 to 0.50. AUC of the clinical risk score was 0.85 (95% CI, 0.79 to 0.91 with a sensitivity of 0.91 (95% CI, 0.71 to 0.98 and a specificity of 0.64 (95% CI, 0.59 to 0.67. 148 misclassifications using NT-proBNP and 55 using the clinical risk score revealed a significant difference (McNemar test; p Conclusion The evaluation of clinical information is at least as effective as NT-proBNP testing in ruling out left ventricular systolic dysfunction in family practice patients at risk. If these results are confirmed in larger cohorts and in different samples, family physicians should be encouraged to rely on the diagnostic power of the clinical information from their patients.

  5. 8-isorpostanes – markers for oxidative stress in obstructive sleep apnea patients with systolic dysfunction

    Directory of Open Access Journals (Sweden)

    Cherneva RV

    2013-06-01

    Full Text Available Radostina Vlaeva Cherneva,1 Ognian Borisov Georgiev,1 Daniela Stoichkova Petrova,1 Emil Ivanov Manov,2 Sylvia Rumenova Ruseva,3 Vanio Ivanov Mitev,3 Julia Ivanova Petrova4 1Department of Internal Medicine, Division of Pulmonary Medicine, Medical University of Sofia, Sofia, Bulgaria; 2Department of Internal Medicine, Division of Cardiology, Medical University of Sofia, Sofia, Bulgaria; 3Department of Medical Chemistry and Biochemistry, Laboratory of Synthesis and Analysis of Bioactive Substances, Medical University of Sofia, Sofia, Bulgaria; 4Department of Neurology, Medical University of Sofia, Sofia, Bulgaria Objective: Increased oxidative stress is considered to be an independent risk factor for cardiovascular diseases, but remains disputed in obstructive sleep apnea (OSA. Among oxidative stress markers, isorpostanes are considered to be the most sensitive and specific. Aims: The aim of the study was to compare urinary isorpostanes in patients with OSA and systolic dysfunction to patients with OSA and preserved ejection fraction (EF and determine their role as markers for increased oxidative stress and early cardiac damage. Materials and methods: Urinary 8F2-isorpostanes were measured in 30 patients with OSA and mild systolic dysfunction (EF = 45.7% ± 6.17% and compared to 15 patients with OSA and normal EF (EF = 60.3% ± 6.3%. Univariate regression analysis was performed to find predictors of left systolic dysfunction. Correlations between 8-isorpostanes, anthropometric, metabolic, and sleep study characteristics were explored. In addition, in 19 patients the effect of bilevel positive airway pressure (BiPAP therapy was evaluated during a 3 month follow-up. Markers of hemodynamic stress, N-terminal prohormone of brain natriuretic peptide and oxidative stress, measured by 8-isorpostanes were compared before and after the follow-up. Results: Urinary levels of 8-isorpostanes were significantly higher in the group with mild systolic dysfunction

  6. Slip patterns and preferred dislocation boundary planes

    DEFF Research Database (Denmark)

    Winther, G.

    2003-01-01

    The planes of deformation induced extended planar dislocation boundaries are analysed in two different co-ordinate systems, namely the macroscopic system defined by the deformation axes and the crystallographic system given by the crystallographic lattice. The analysis covers single and polycryst......The planes of deformation induced extended planar dislocation boundaries are analysed in two different co-ordinate systems, namely the macroscopic system defined by the deformation axes and the crystallographic system given by the crystallographic lattice. The analysis covers single...... and polycrystals of fcc metals in three deformation modes (rolling, tension and torsion). In the macroscopic system, boundaries lie close to the macroscopically most stressed planes. In the crystallographic system, the boundary plane depends on the grain/crystal orientation. The boundary planes in both co......-ordinate systems are rationalised based on the slip. The more the slip is concentrated on a slip plane, the closer the boundaries lie to this. The macroscopic preference arises from the macroscopic directionality of the slip. The established relations are applied to (a) prediction of boundary planes from slip...

  7. Relative Paleointensity and Magnetic Excursions in the Last 3 Myrs During Transitions in North Atlantic Paleoceanography: Comparison of the Brunhes and Matuyama Chrons

    Science.gov (United States)

    Channell, J. E. T.; Crowhurst, S.; Hodell, D. A.

    2016-12-01

    The IODP Site U1308 paleomagnetic record now extends back to the Kaena Subchron at 3 Ma at a mean sedimentation rate of 8.2 cm/kyr. Other North Atlantic sites recovered during IODP Exp. 303 (U1302/3, U1304, U1305, U1306) provide paleomagnetic records that cover part of the time interval at sedimentation rates in excess of 10 cm/kyr, allowing a reassessment and extension of the PISO-1500 relative paleointensity (RPI) stack. As for PISO, the new records do not provide evidence for decreased mean virtual axial dipole moment (VADM) in the Matuyama Chron relative to the Brunhes Chron. The Iceland Basin and Laschamp excursions in the Brunhes Chron, and several excursions in the Matuyama Chron (Punaruu, Bjorn, and Gardar), have now been recorded at multiple North Atlantic sites. Four excursions have been recorded in the 280-590 ka interval, by both u-channel and discrete samples, at multiple holes at Sites U1302/3, U1305, and U1306; although individual excursions are not recorded at all three sites even though the sites have similar mean sedimentation rates. Irregular recording of these magnetic excursions, and excursions in general, is attributed to a combination of filtering by the process of acquisition of detrital remanent magnetization (DRM), the millennial or even centennial duration of directional magnetic excursions, and non-uniform sedimentation rates in sediment drifts at these timescales. At Site U1308, local wavelet power spectra (LWPS) of RPI and of other magnetic parameters are compared with the LWPS of climate/lithologic parameters during intensification of Northern Hemisphere Glaciation. Cross-wavelet power spectra (XWT) and squared wavelet coherence (WTC) indicate that Site U1308 RPI has coherent common power with magnetic susceptibility and other magnetic concentration parameters at periods of 400 kyr prior to 1.5 Ma. For a short time interval during the Middle Pleistocene climate transition (MPT) at 900 ka, Site U1308 RPI has common power with the

  8. Influence of mandibular fixation method on stability of the maxillary occlusal plane after occlusal plane alteration.

    Science.gov (United States)

    Yosano, Akira; Katakura, Akira; Takaki, Takashi; Shibahara, Takahiko

    2009-05-01

    In this study, we investigated how method of mandibular fixation influenced longterm postoperative stability of the maxilla in Class III cases. In particular, we investigated change in the maxillary occlusal plane after Occlusal Plane Alteration. Therefore, we focused on change in the palatal plane to evaluate stability of the maxillary occlusal plane, as the position of the palatal plane affects the maxillary occlusal plane. This study included 16 patients diagnosed with mandibular protrusion. Alteration of the occlusal plane was achieved by clockwise rotation of the maxilla by Le Fort I osteotomy and mandibular setback was performed by bilateral sagittal split ramus osteotomy. We analyzed and examined lateral cephalometric radiographs taken at 1 month, 3 months, 6 months, and 1 year after surgery. Stability achieved by two methods of mandibular fixation was compared. In one group of patients (group S) titanium screws were used, and in the other group (group P) titanium-locking mini-plates were used. No significant displacement was recognized in group S, whereas an approximately 0.7mm upward vertical displacement was recognized in the anterior nasal spine in group P. As a result, not only the angle of the palatal plane and S-N plane, but also occlusal plane angle in group P showed a greater decrease than that in group S. The results suggest that fixing the mandible with screws yielded greater stability of the maxilla and maxillary occlusal plane than fixing the mandible with titanium plates.

  9. Streptococcus anginosus infections: crossing tissue planes.

    Science.gov (United States)

    Sunwoo, Bernie Y; Miller, Wallace T

    2014-10-01

    Streptococcus anginosus has long been recognized to cause invasive pyogenic infections. This holds true for thoracic infections where S. anginosus has a propensity for abscess and empyema formation. Early diagnosis is important given the significant morbidity and mortality associated with thoracic S. anginosus infections. Yet, distinguishing thoracic S. anginosus clinically is difficult. We present three cases of thoracic S. anginosus that demonstrated radiographic extension across tissue planes, including the interlobar fissure, diaphragm, and chest wall. Few infectious etiologies are known to cross tissue planes. Accordingly, we propose S. anginosus be considered among the differential diagnosis of potential infectious etiologies causing radiographic extension across tissue planes.

  10. A full-vector paleomagnetic secular variation record (PSV) from Pyramid Lake (Nevada) from 47-17 ka: Evidence for the successive Mono Lake and Laschamp Excursions

    Science.gov (United States)

    Lund, S.; Benson, L.; Negrini, R.; Liddicoat, J.; Mensing, S.

    2017-01-01

    We have carried out a paleomagnetic study of late-Pleistocene Pyramid Lake core PLC08-1 (1680 cm). Our goals were to develop a full-vector paleomagnetic secular variation (PSV) record for the core, establish a paleomagnetic chronostratigraphy for the lake based on correlation of the PSV record to other dated PSV records in the region, compare that chronostratigraphy with previously developed radiocarbon and ash chronologies, and search for evidence of the Mono Lake Excursion and Laschamp Excursion. We have recovered a full-vector PSV record (inclination, declination, relative paleointensity) for the interval 47 ka to 17 ka. Twenty radiocarbon dates and four dated ashes provided a chronostratigraphic framework for this record. We have also used the link between our PSV and other dated PSV records to develop an independent PSV chronostratigraphy for the core. The PSV chronostratigraphy is not significantly different from that estimated by the radiocarbon and ash chronologies. We note the existence of two intervals of anomalous paleomagnetic directions. The younger interval, centered at 34.1 ± 0.4 ka, has the characteristic vector component features of the Mono Lake Excursion. The older interval, centered at 40.9 ± 0.5 ka, has the characteristic paleomagnetic signature of the Laschamp Excursion. This is the first time both intervals of excursional behavior have been found in the same sediment record from the western USA. Our new PSV record also corroborates previous estimates of the Mono Lake Excursion directional field behavior (Liddicoat and Coe, 1979) and age (Benson et al., 2003).

  11. Structure of the carbon isotope excursion in a high-resolution lacustrine Paleocene-Eocene Thermal Maximum record from central China

    Science.gov (United States)

    Chen, Zuoling; Wang, Xu; Hu, Jianfang; Yang, Shiling; Zhu, Min; Dong, Xinxin; Tang, Zihua; Peng, Ping'an; Ding, Zhongli

    2014-12-01

    The carbon isotope excursion (CIE) associated with the Paleocene-Eocene Thermal Maximum (PETM) has been recognized for the first time in the micritic carbonate, total organic carbon (TOC) and black carbon (BC) contained within the lacustrine sediments from the Nanyang Basin, central China. The remarkably large excursion (∼ - 6 ‰) in the δ13CTOC and δ13CBC values is possibly attributable to increased humidity and elevated pCO2 concentration. The ∼ - 4 ‰ CIE recorded in the δ13Ccalcite, reflecting the average isotope change of the watershed system, is consistent with that observed in planktonic foraminifera. This correspondence suggests that the true magnitude of the carbon isotope excursion in the ocean-atmosphere system is likely close to - 4 ‰. The ∼10 m excursion onset in our multi-proxy δ13C records demonstrates that the large input of 13C-depleted carbon into the ocean-atmosphere system was not geologically instantaneous. Despite difference and somewhat smoothness in detailed pattern of the CIE due to localized controls on different substrates, inorganic and organic δ13C data generally depict a gradual excursion onset at least over timescales of thousands of years. In addition, continental temperature reconstruction, based on the distribution of membrane lipids of bacteria, suggests a warming of ∼4 °C prior to the PETM and ∼7 °C increase in temperature during the PETM. The temperature data are overall similar in pattern and trend to the δ13C change across the PETM. These observations, combined with pre-CIE warming, are in line with the idea that 13C-depleted carbon release operated as a positive feedback to temperature, suggesting supply from one or more large organic carbon reservoirs on Earth's surface.

  12. Two-dimensional speckle-tracking-derived segmental peak systolic longitudinal strain identifies regional myocardial involvement in patients with myocarditis and normal global left ventricular systolic function.

    Science.gov (United States)

    Uppu, Santosh C; Shah, Amee; Weigand, Justin; Nielsen, James C; Ko, H Helen; Parness, Ira A; Srivastava, Shubhika

    2015-06-01

    The presence of myocardial late gadolinium enhancement (LGE) by cardiac magnetic resonance (CMR) imaging in concert with electrocardiography and elevated biomarkers helps support the diagnosis of acute myocarditis. Two-dimensional echocardiography is limited to global and qualitative regional function assessment and may not contribute to the diagnosis, especially in the presence of normal LV systolic function. Two-dimensional speckle-tracking (2D-STE)-derived segmental peak systolic (pkS) longitudinal strain (LS) may identify segmental myocardial involvement in myocarditis. We sought to identify an association between segmental pkS, LGE, and troponin levels in patients with myocarditis. Retrospective analysis of myocardial segmental function by 2D-STE segmental strain was compared to the presence of LGE and admission peak troponin levels in patients with acute myocarditis and preserved global LV systolic function. American Heart Association 17-segment model was used for comparison between imaging modalities. Global function was assessed by m-mode-derived shortening fraction (SF). Descriptive statistics and regression analysis were utilized. Forty-four CMRs performed to evaluate for myocarditis were identified. Of the 44, 10 patients, median age 17.5 years (14-18.5 years) and median SF 35 % (28-44 %), had paired CMR and 2D-STE data for analysis, and 161/170 segments could be analyzed by both methods for comparison. PkS LS was decreased in 51 % of segments that were positive for LGE with average pkS of -14.7 %. Segmental pkS LS abnormalities were present in all but one patient who had abnormal pkS circumferential strain. Global pkS LS was decreased in patients with myocarditis. There is a moderate correlation between decreased pkS LS and the presence of LGE by CMR, 2D-STE for myocardial involvement in acute myocarditis can serve as an useful noninvasive adjunct to the existing tests used for the diagnosis of acute myocarditis and might have a role in prognostication.

  13. Multivariate Modeling of Body Mass Index, Pulse Pressure, Systolic and Diastolic Blood Pressure in Chinese Twins

    DEFF Research Database (Denmark)

    Wu, Yili; Zhang, Dongfeng; Pang, Zengchang;

    2015-01-01

    Systolic and diastolic blood pressure, pulse pressure (PP), and body mass index (BMI) are heritable traits in human metabolic health but their common genetic and environmental backgrounds are not well investigated. The aim of this article was to explore the phenotypic and genetic associations among...... PP, systolic blood pressure (SBP), diastolic blood pressure (DBP), and BMI. The studied sample contained 615 twin pairs (17-84 years) collected in the Qingdao municipality. Univariate and multivariate structural equation models were fitted for assessing the genetic and environmental contributions...... model estimated (1) high genetic correlations for DBP with SBP (0.87), PP with SBP (0.75); (2) low-moderate genetic correlations between PP and DBP (0.32), each BP component and BMI (0.24-0.37); (3) moderate unique environmental correlation for PP with SBP (0.68) and SBP with DBP (0.63); (4...

  14. Indices of left ventricular systolic function derived by computer analysis of digitised M-mode echocardiograms.

    Science.gov (United States)

    Bett, J H; Dryburgh, L G; Boyle, C M

    1985-04-01

    In order to determine the value of computer-assisted analysis of echocardiograms we digitised 980 M-mode studies in normal subjects and patients with pressure and volume overload and heart muscle disease to derive left ventricular dimensions (D), peak systolic rate of change of dimension, normalized for instantaneous dimension (dD/dt/D), mean velocity of circumferential fiber shortening (mean Vcf) and percentage fractional shortening (%FS). The systolic phase indices which, in these patients averaged greater than normal in those with aortic stenosis and hypertrophic cardiomyopathy and lower than normal in those with aortic regurgitation, mitral stenosis and dilated cardiomyopathy, were closely related to each other in all categories of patients. Measurement of % FS appears to describe left ventricular function as well as the more complex indices (mean Vcf, peak dD/dt/D).

  15. Influence of renal impairment on myocardial function in outpatients with systolic heart failure

    DEFF Research Database (Denmark)

    Bosselmann, Helle; Tønder, Niels; Sölétormos, György

    2014-01-01

    BACKGROUND: Renal dysfunction (RD) is associated with poor outcome in systolic heart failure (HF). Left ventricular ejection fraction (LVEF) is not depressed to a greater extent in patients with RD compared to patients with normal renal function, but it is relatively unknown whether other measures...... of myocardial function are impaired by RD. The objective of the present study is to evaluate whether RD in systolic HF is associated with excessive impairment of myocardial function, evaluated by strain analysis and cardiac biomarkers. METHODS: Patients with LVEF ... models were developed to evaluate the associations between eGFR groups, echocardiographic measures and cardiac biomarkers. RESULTS: A total of 149 patients participated in the study. Median age was 69 years, 26% were female; LVEF was 33%. Patients with a low eGFR were older (P

  16. DNA-Cryptography-Based Obfuscated Systolic Finite Field Multiplier for Secure Cryptosystem in Smart Grid

    Science.gov (United States)

    Chen, Shaobo; Chen, Pingxiuqi; Shao, Qiliang; Basha Shaik, Nazeem; Xie, Jiafeng

    2017-05-01

    The elliptic curve cryptography (ECC) provides much stronger security per bits compared to the traditional cryptosystem, and hence it is an ideal role in secure communication in smart grid. On the other side, secure implementation of finite field multiplication over GF(2 m ) is considered as the bottle neck of ECC. In this paper, we present a novel obfuscation strategy for secure implementation of systolic field multiplier for ECC in smart grid. First, for the first time, we propose a novel obfuscation technique to derive a novel obfuscated systolic finite field multiplier for ECC implementation. Then, we employ the DNA cryptography coding strategy to obfuscate the field multiplier further. Finally, we obtain the area-time-power complexity of the proposed field multiplier to confirm the efficiency of the proposed design. The proposed design is highly obfuscated with low overhead, suitable for secure cryptosystem in smart grid.

  17. Lymphoma Presenting as Severe Left Ventricular Systolic Dysfunction: A Case Report

    Directory of Open Access Journals (Sweden)

    Imran Hafeez

    2014-05-01

    Full Text Available Lymphoma involving the heart is rare. This is a case report on non-Hodgkin lymphoma where the patient presented for the first time with heart failure and severe left ventricular systolic dysfunction due to lymphoma infiltrating the heart muscle and had simultaneous bilateral involvement of kidneys. This type of presentation has never been described in world literature and is the first reported case.

  18. Effects of parental smoking on exercise systolic blood pressure in adolescents.

    Science.gov (United States)

    Hacke, Claudia; Weisser, Burkhard

    2015-05-11

    In adults, exercise blood pressure seems to be more closely related to cardiovascular risk than resting blood pressure; however, few data are available on the effects of familial risk factors, including smoking habits, on exercise blood pressure in adolescents. Blood pressure at rest and during exercise, parental smoking, and other familial risk factors were investigated in 532 adolescents aged 12 to 17 years (14.6±1.5 years) in the Kiel EX.PRESS. (EXercise PRESSure) Study. Exercise blood pressure was determined at 1.5 W/kg body weight using a standardized submaximal cycle ergometer test. Mean resting blood pressure was 113.1±12.8/57.2±7.1 mm Hg, and exercise blood pressure was 149.9±19.8/54.2±8.6 mm Hg. Parental smoking increased exercise systolic blood pressure (+4.0 mm Hg, 3.1 to 4.9; P=0.03) but not resting blood pressure of the subjects (adjusted for age, sex, height, body mass index percentile, fitness). Parental overweight and familial hypertension were related to both higher resting and exercise systolic blood pressure values, whereas associations with an inactive lifestyle and a low educational level of the parents were found only with adolescents' blood pressure during exercise. The cumulative effect of familial risk factors on exercise systolic blood pressure was more pronounced than on blood pressure at rest. Parental smoking might be a novel risk factor for higher blood pressure, especially during exercise. In addition, systolic blood pressure during a submaximal exercise test was more closely associated with familial risk factors than was resting blood pressure, even in adolescents. © 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

  19. Pulmonary endarterectomy normalizes interventricular dyssynchrony and right ventricular systolic wall stress

    Directory of Open Access Journals (Sweden)

    Mauritz Gert-Jan

    2012-01-01

    Full Text Available Abstract Background Interventricular mechanical dyssynchrony is a characteristic of pulmonary hypertension. We studied the role of right ventricular (RV wall stress in the recovery of interventricular dyssynchrony, after pulmonary endarterectomy (PEA in chronic thromboembolic pulmonary hypertension (CTEPH. Methods In 13 consecutive patients with CTEPH, before and 6 months after pulmonary endarterectomy, cardiovascular magnetic resonance myocardial tagging was applied. For the left ventricular (LV and RV free walls, the time to peak (Tpeak of circumferential shortening (strain was calculated. Pulmonary Artery Pressure (PAP was measured by right heart catheterization within 48 hours of PEA. Then the RV free wall systolic wall stress was calculated by the Laplace law. Results After PEA, the left to right free wall delay (L-R delay in Tpeak strain decreased from 97 ± 49 ms to -4 ± 51 ms (P P = 0.18. The RV wall stress decreased significantly from 15.2 ± 6.4 kPa to 5.7 ± 3.4 kPa (P P = 0.78. The reduction of L-R delay in Tpeak was more strongly associated with the reduction in RV wall stress (r = 0.69,P = 0.007 than with the reduction in systolic PAP (r = 0.53, P = 0.07. The reduction of L-R delay in Tpeak was not associated with estimates of the reduction in RV radius (r = 0.37,P = 0.21 or increase in RV systolic wall thickness (r = 0.19,P = 0.53. Conclusion After PEA for CTEPH, the RV and LV peak strains are resynchronized. The reduction in systolic RV wall stress plays a key role in this resynchronization.

  20. Vascular calcification is not associated with increased ambulatory central aortic systolic pressure in prevalent dialysis patients

    Science.gov (United States)

    Freercks, Robert J; Swanepoel, Charles R; Turest-Swartz, Kristy L; Rayner, Brian L; Carrara, Henri RO; Moosa, Sulaiman EI; Lachman, Anthony S

    2014-01-01

    Summary Introduction Central aortic systolic pressure (CASP) strongly predicts cardiovascular outcomes. We undertook to measure ambulatory CASP in 74 prevalent dialysis patients using the BPro (HealthStats, Singapore) device. We also determined whether coronary or abdominal aortic calcification was associated with changes in CASP and whether interdialytic CASP predicted ambulatory measurement. Methods All patients underwent computed tomography for coronary calcium score, lateral abdominal radiography for aortic calcium score, echocardiography for left ventricular mass index and ambulatory blood pressure measurement using BPro calibrated to brachial blood pressure. HealthStats was able to convert standard BPro SOFT® data into ambulatory CASP. Results Ambulatory CASP was not different in those without and with coronary (137.6 vs 141.8 mmHg, respectively, p = 0.6) or aortic (136.6 vs 145.6 mmHg, respectively, p = 0.2) calcification. Furthermore, when expressed as a percentage of brachial systolic blood pressure to control for peripheral blood pressure, any difference in CASP was abolished: CASP: brachial systolic blood pressure ratio = 0.9 across all categories regardless of the presence of coronary or aortic calcification (p = 0.2 and 0.4, respectively). Supporting this finding, left ventricular mass index was also not different in those with or without vascular calcification (p = 0.7 and 0.8 for coronary and aortic calcification). Inter-dialytic office blood pressure and CASP correlated excellently with ambulatory measurements (r = 0.9 for both). Conclusion Vascular calcification was not associated with changes in ambulatory central aortic systolic pressure in this cohort of prevalent dialysis patients. Inter-dialytic blood pressure and CASP correlated very well with ambulatory measurement. PMID:24626513

  1. [Chronic systolic heart failure - dosing recommendations at beginning and end of treatment].

    Science.gov (United States)

    Zugck, Christian; Remppis, Andrew; Katus, Hugo A; Frankenstein, Lutz

    2008-10-01

    As a multi-system disease, chronic heart failure requires a complex, multimodal therapy. Achieving maximum guideline adherence in (advanced) chronic heart failure can therefore become a challenge. The important decrease in morbidity and mortality seen lately largely depends on consequent and sometime tedious implementation of guideline targets. The present paper provides a comprehensive overview on medical therapeutic strategies with a particular focus of onset and discontinuation of drugs in patients with chronic systolic dysfunction.

  2. Doppler-derived myocardial systolic strain rate is a strong index of left ventricular contractility

    Science.gov (United States)

    Greenberg, Neil L.; Firstenberg, Michael S.; Castro, Peter L.; Main, Michael; Travaglini, Agnese; Odabashian, Jill A.; Drinko, Jeanne K.; Rodriguez, L. Leonardo; Thomas, James D.; Garcia, Mario J.

    2002-01-01

    BACKGROUND: Myocardial fiber strain is directly related to left ventricular (LV) contractility. Strain rate can be estimated as the spatial derivative of velocities (dV/ds) obtained by tissue Doppler echocardiography (TDE). The purposes of the study were (1) to determine whether TDE-derived strain rate may be used as a noninvasive, quantitative index of contractility and (2) to compare the relative accuracy of systolic strain rate against TDE velocities alone. METHODS AND RESULTS: TDE color M-mode images of the interventricular septum were recorded from the apical 4-chamber view in 7 closed-chest anesthetized mongrel dogs during 5 different inotropic stages. Simultaneous LV volume and pressure were obtained with a combined conductance-high-fidelity pressure catheter. Peak elastance (Emax) was determined as the slope of end-systolic pressure-volume relationships during caval occlusion and was used as the gold standard of LV contractility. Peak systolic TDE myocardial velocities (Sm) and peak (epsilon'(p)) and mean (epsilon'(m)) strain rates obtained at the basal septum were compared against Emax by linear regression. Emax as well as TDE systolic indices increased during inotropic stimulation with dobutamine and decreased with the infusion of esmolol. A stronger association was found between Emax and epsilon'(p) (r=0.94, P<0.01, y=0.29x+0.46) and epsilon'(m) (r=0.88, P<0.01) than for Sm (r=0.75, P<0.01). CONCLUSIONS: TDE-derived epsilon'(p) and epsilon'(m) are strong noninvasive indices of LV contractility. These indices appear to be more reliable than S(m), perhaps by eliminating translational artifact.

  3. Systolic-diastolic functional coupling in healthy children and in those with dilated cardiomyopathy.

    Science.gov (United States)

    Friedberg, Mark K; Margossian, Renee; Lu, Minmin; Mercer-Rosa, Laura; Henderson, Heather T; Nutting, Arni; Friedman, Kevin; Molina, Kimberly M; Altmann, Karen; Canter, Charles; Sleeper, Lynn A; Colan, Steven D

    2016-06-01

    Systolic and diastolic function affect dilated cardiomyopathy (DCM) outcomes. However, systolic-diastolic coupling, as a distinct characteristic, may itself affect function but is poorly characterized. We hypothesized that echocardiographic left ventricular (LV) longitudinal systolic tissue velocities (S') correlate with diastolic longitudinal velocities (E') and that their relationship is associated with ventricular function and that this relationship is impaired in pediatric DCM. We analyzed data from the Pediatric Heart Network Ventricular Volume Variability study, using linear regression and generalized additive modeling to assess relationships between S' and E' at the lateral and septal mitral annulus. We explored relationships between the systolic:diastolic (S:D) coupling ratio (S':E' relative to age) and ventricular function. Up to 4 echocardiograms from 130 DCM patients (mean age: 9.3 ± 6.1 yr) and 1 echocardiogram from each of 591 healthy controls were analyzed. S' and E' were linearly related in controls (r = 0.64, P < 0.001) and DCM (r = 0.83, P < 0.001). In DCM, the magnitude of association between S' and E' was reduced with progressive ventricular remodeling. The S:D ratio was more strongly associated with LV function in controls vs. DCM. The septal S:D ratio was higher (presumed worse) in DCM vs. controls (0.69 ± 0.13 vs. 0.62 ± 0.12, P = 0.001). A higher septal S:D ratio was associated with worse LV dimensions (parameter estimate: 0.0061, P = 0.004), mass (parameter estimate: 0.0074, P = 0.002), ejection fraction (parameter estimate: -0.0303, P = 0.024), and inflow propagation (parameter estimate: -0.3538, P < .001). S:D coupling becomes weaker in DCM with LV remodeling and dysfunction. The S:D coupling ratio may be useful to assess coupling, warranting study in relation to patient outcomes. Copyright © 2016 the American Physiological Society.

  4. Significance of white-coat hypertension in older persons with isolated systolic hypertension

    DEFF Research Database (Denmark)

    Franklin, Stanley S; Thijs, Lutgarde; Hansen, Tine W;

    2012-01-01

    The significance of white-coat hypertension in older persons with isolated systolic hypertension remains poorly understood. We analyzed subjects from the population-based 11-country International Database on Ambulatory Blood Pressure Monitoring in Relation to Cardiovascular Outcomes database who...... had daytime ambulatory blood pressure (BP; ABP) and conventional BP (CBP) measurements. After excluding persons with diastolic hypertension by CBP (=90 mm Hg) or by daytime ABP (=85 mm Hg), a history of cardiovascular disease, and persons...

  5. Left ventricular dimensions and systolic function during spontaneous heart rate changes: an echocardiographic study.

    Science.gov (United States)

    Bett, J H; Dryburgh, L

    1981-06-01

    We examined the relationships between spontaneous heart rate (or conversely cycle length) changes and left ventricular diastolic dimensions and indices of systolic function in twenty-three subjects. In most there was clearly an inverse relationship between rate and these indices and nearly always a positive correlation between performance and end-diastolic dimension. Previously described relationship between heart rate and mean velocity of circumferential fiber shortening are applicable only when the heart rate is constant.

  6. Crossover comparison of atenolol, enalapril, hydrochlorothiazide and isradipine for isolated systolic systemic hypertension.

    Science.gov (United States)

    Silagy, C A; McNeil, J J; McGrath, B P

    1992-11-15

    The benefit of antihypertensive therapy in reducing cardiovascular morbidity and mortality associated with isolated systolic hypertension has now been established by the Systolic Hypertension in the Elderly Program. However, there is little information about the relative effectiveness of different drug regimens in this condition. This study compared the efficacy and tolerability of 50 mg of atenolol, 10 mg of enalapril, 25 mg of hydrochlorothiazide and 2.5 mg of isradipine in the treatment of isolated systolic hypertension. After a 3-week placebo run-in phase, 24 subjects were randomized into a 4-period double-blind crossover study by use of an orthogonal latin square design. Treatment periods were of 6 weeks' duration with titration to a higher dose after 4 weeks in those not reaching goal blood pressure (BP). Each active treatment was followed by a 3-week placebo washout. Casual clinic and 24-hour ambulatory BP (Accutracker II) were measured at the end of each treatment phase. Routine biochemistry was also performed after the placebo run-in, at the end of each active treatment phase, and after the placebo run-out. Of the 24 subjects entered (mean age 72.3 years, 38% men) 20 completed the whole study. Mean +/- standard deviation of supine clinic and daytime ambulatory BP on entry were 181/79 +/- 21/9 mm Hg and 165/82 +/- 23/15 mm Hg, respectively. All drugs reduced mean casual and ambulatory BP significantly relative to placebo but only hydrochlorothiazide and enalapril produced a consistent hypotensive effect throughout the entire 24-hour period. Isradipine and enalapril exhibited a relatively greater effect on reducing systolic BP than either hydrochlorothiazide or atenolol.(ABSTRACT TRUNCATED AT 250 WORDS)

  7. Decreased mitochondrial oxidative phosphorylation capacity in the human heart with left ventricular systolic dysfunction

    DEFF Research Database (Denmark)

    Stride, Nis; Larsen, Steen; Hey-Mogensen, Martin

    2013-01-01

    Heart failure (HF) with left ventricular systolic dysfunction (LVSD) is associated with a shift in substrate utilization and a compromised energetic state. Whether these changes are connected with mitochondrial dysfunction is not known. We hypothesized that the cardiac phenotype in LVSD could...... be caused by reduced mitochondrial oxidative phosphorylation (OXPHOS) capacity and reduced mitochondrial creatine kinase (miCK) capacity. The study aim was to test mitochondrial OXPHOS capacity in LVSD myocardium compared with OXPHOS capacity in a comparable patient group without LVSD....

  8. Coronary artery ectasia and systolic flow cessation in a patient with hypertrophic cardiomyopathy: a case report.

    Science.gov (United States)

    Zografos, Theodoros; Kokladi, Maria; Katritsis, Demosthenes

    2010-12-01

    Coronary artery ectasia (CAE) is characterized by diffuse or localized inappropriate dilation of coronary arteries and is often associated with slow coronary blood flow. Although CAE has been described to coexist with several clinical entities there are only three reports of CAE in the presence of hypertrophic cardiomyopathy (HCM). We report a case of CAE and slow coronary flow with systolic flow cessation in a 61-year old male with coronary artery disease and HCM.

  9. Exposure to fipronil elevates systolic blood pressure and disturbs related biomarkers in plasma of rats.

    Science.gov (United States)

    Chaguri, Joao Leandro; Godinho, Antonio Francisco; Horta, Daniel França; Gonçalves-Rizzi, Victor Hugo; Possomato-Vieira, Jose Sergio; Nascimento, Regina Aparecida; Dias-Junior, Carlos Alan

    2016-03-01

    Recent reports show that fipronil affects non-target organisms, including environmental species populations and potentially humans. We aimed to examine if fipronil exposure affects the systolic blood pressure and related biomarkers. Thus, fipronil was orally administered to rats (30 mg/kg/day) during 15 days (Fipronil group) or physiological solution (Control group). While fipronil increased significantly the systolic blood pressure (158±13 mmHg), no significant changes were observed in Control group (127±3 mmHg). Significantly, higher levels of fipronil in plasma were observed in Fipronil group (0.46±0.09 μg/mL versus 0.17±0.11 μg/mL in Control group). Fipronil group showed lower weight gain compared with Control group. While fipronil resulted in higher concentrations of endothelin-1, reduced antioxidant capacity and lower levels of circulating matrix metalloproteinase 2 (MMP-2) and nitric oxide (NO) metabolites compared to Control group, no alteration was observed in serum biomarkers of renal and hepatic/biliary functional abilities. Therefore, this study suggests that fipronil causes hypertension and endothelin-1 plays a key role. Also, these findings suggest that reductions of both MMP-2 and NO may contribute with the elevation of systolic blood pressure observed with fipronil.

  10. Significance of White-Coat Hypertension in Older Persons With Isolated Systolic Hypertension

    Science.gov (United States)

    Franklin, Stanley S.; Thijs, Lutgarde; Hansen, Tine W.; Li, Yan; Boggia, José; Kikuya, Masahiro; Björklund-Bodegård, Kristina; Ohkubo, Takayoshi; Jeppesen, Jørgen; Torp-Pedersen, Christian; Dolan, Eamon; Kuznetsova, Tatiana; Stolarz-Skrzypek, Katarzyna; Tikhonoff, Valérie; Malyutina, Sofia; Casiglia, Edoardo; Nikitin, Yuri; Lind, Lars; Sandoya, Edgardo; Kawecka-Jaszcz, Kalina; Imai, Yutaka; Wang, Jiguang; Ibsen, Hans; O’Brien, Eoin; Staessen, Jan A.

    2013-01-01

    The significance of white-coat hypertension in older persons with isolated systolic hypertension remains poorly understood. We analyzed subjects from the population-based 11-country International Database on Ambulatory Blood Pressure Monitoring in Relation to Cardiovascular Outcomes database who had daytime ambulatory blood pressure (BP; ABP) and conventional BP (CBP) measurements. After excluding persons with diastolic hypertension by CBP (≥90 mm Hg) or by daytime ABP (≥85 mm Hg), a history of cardiovascular disease, and persons hypertension. During a median follow-up of 10.6 years, there was a total of 655 fatal and nonfatal cardiovascular events. The analyses were stratified by treatment status. In untreated subjects, those with white-coat hypertension (CBP ≥140/hypertension, the cardiovascular risk was similar in elevated conventional and normal daytime systolic BP as compared with those with normal conventional and normal daytime BPs (adjusted hazard rate: 1.10 [95% CI: 0.79–1.53]; P=0.57). However, both treated isolated systolic hypertension subjects with white-coat hypertension (adjusted hazard rate: 2.00; [95% CI: 1.43–2.79]; Phypertension who have their ABP normalized on antihypertensive therapy but with residual white-coat effect by CBP measurement have an entity that we have termed, “treated normalized hypertension.” Therefore, one should be cautious in applying the term “white-coat hypertension” to persons receiving antihypertensive treatment. PMID:22252396

  11. Speckle-Tracking analysis of left ventricular systolic function in the intensive care unit.

    Science.gov (United States)

    Cinotti, Raphaël; Delater, Adrien; Fortuit, Camille; Roquilly, Antoine; Mahé, Pierre-Joachim; Demeure-dit-Latte, Dominique; Asehnoune, Karim

    2015-01-01

    Speckle-tracking analysis is a new available tool in order to assess left ventricular function in cardiology. Its novelty relies on the technological ability to track natural acoustic markers (known as speckle) within the myocardium during the cardiac cycle. This technology allows the evaluation of myocardium strain during systole and diastole. To date, global longitudinal strain (GLS) has been extensively studied in cardiology. It is now well established that GLS is more sensitive than left ventricular ejection fraction with 2D echocardiography in detecting systolic function impairment. It is also superior to left ventricular ejection fraction in the prediction of major cardio-vascular events. In the intensive care unit (ICU) setting, data are scarce. In experimental model and human studies in septic shock, speckle-tracking analysis suggests that GSL is impaired along with preserved left ventricular ejection fraction. Recent data also suggest that GLS impairment could predict in-ICU mortality in septic shock. In severe subarachnoid haemorrhage patients, speckle-tracking analysis could be more sensitive in detecting stress cardiomyopathy. However, there are many gaps to fill in the critically ill patient. For instance, the influence of mechanical ventilation on GLS is not fully elucidated, and there are, to date, too few data to exactly assess potential GLS alterations on the patient's outcome. Nonetheless, this new tool provides objective and sensitive data with acceptable intra and inter-observer variability and may be of primary interest in the evaluation of left-ventricular systolic function in the ICU.

  12. Automatic detection of end-diastole and end-systole from echocardiography images using manifold learning.

    Science.gov (United States)

    Gifani, Parisa; Behnam, Hamid; Shalbaf, Ahmad; Sani, Zahra Alizadeh

    2010-09-01

    The automatic detection of end-diastole and end-systole frames of echocardiography images is the first step for calculation of the ejection fraction, stroke volume and some other features related to heart motion abnormalities. In this paper, the manifold learning algorithm is applied on 2D echocardiography images to find out the relationship between the frames of one cycle of heart motion. By this approach the nonlinear embedded information in sequential images is represented in a two-dimensional manifold by the LLE algorithm and each image is depicted by a point on reconstructed manifold. There are three dense regions on the manifold which correspond to the three phases of cardiac cycle ('isovolumetric contraction', 'isovolumetric relaxation', 'reduced filling'), wherein there is no prominent change in ventricular volume. By the fact that the end-systolic and end-diastolic frames are in isovolumic phases of the cardiac cycle, the dense regions can be used to find these frames. By calculating the distance between consecutive points in the manifold, the isovolumic frames are mapped on the three minimums of the distance diagrams which were used to select the corresponding images. The minimum correlation between these images leads to detection of end-systole and end-diastole frames. The results on six healthy volunteers have been validated by an experienced echo cardiologist and depict the usefulness of the presented method.

  13. Evaluation of left ventricular systolic function in young adults with mitral valve prolapse

    Science.gov (United States)

    Malev, Eduard; Zemtsovsky, Eduard; Pshepiy, Asiyet; Timofeev, Eugeny; Reeva, Svetlana; Prokudina, Maria

    2012-01-01

    OBJECTIVE: To evaluate left ventricular function in young adults with mitral valve prolapse (MVP) without significant mitral regurgitation using two-dimensional strain imaging. METHODS AND RESULTS: A total of 58 asymptomatic young subjects (mean [± SD] age 19.7±1.6 years; 72% male) with MVP were compared with 60 sex- and age-matched healthy subjects. MVP was diagnosed by billowing one or both mitral leaflets >2 mm above the mitral annulus in the long-axis parasternal view. Longitudinal, radial and circumferential strain and strain rate were determined using speckle tracking with a grey-scale frame rate of 50 fps to 85 fps. There were no significant differences in the global systolic left ventricular function of the subjects with MVP compared with the control group. In the MVP group, most of the global myocardial systolic deformation indexes were not reduced. Only the global circumferential strain showed a decrease in the prolapse subjects. Regional, longitudinal, circumferential and radial strain and strain rate were decreased only in septal segments. A decrease in the rotation of the same septal segments at the basal level was also observed. CONCLUSION: Regional septal myocardial deformation indexes decrease in subjects with MVP. These changes may be the first sign indicating the deterioration of left ventricular systolic function as well as the existence of primary cardiomyopathy in asymptomatic young subjects with MVP. PMID:23592928

  14. Attitude towards knowledge of the disease and psychological characteristics of patients with systolic heart failure

    Directory of Open Access Journals (Sweden)

    Justyna Krzysztofik

    2016-11-01

    Full Text Available Background We aimed to investigate the relationships between selected psychological features of patients with chronic systolic heart failure (HF and their attitude towards knowledge of the disease. Participants and procedure This prospective study among 75 patients with stable systolic HF consisted of 2 parts: a quantitative approach, conducted during the hospitalization (based on 4 psychological questionnaires: the Multidimensional Health Locus of Control Scale; the Coping Inventory for Stressful Situations; the Acceptance of Illness Scale; and the Patient’s Request Form and a qualitative approach (phone interviews performed later. Results Fifty-nine percent of patients declared the need for possessing knowledge about their disease. Psychological questionnaires did not allow us to characterize groups of patients with extremely different attitudes towards knowledge about the disease. Patients who did not want to look for any information, although they admitted that their knowledge was poor, were characterized by the conviction that nobody has an influence on their health status. Patients who were likely to read drug labels were characterized by the active style of coping. Conclusions The attitude towards knowledge about the disease is diverse among patients with systolic HF, and it is not easy to explain these differences using their psychological features assessed in the present study. Further studies focused on assessing the patient’s willingness to acquire knowledge about HF, using more accurate measures, are needed, especially for healthcare professionals, who still look for an improvement in understanding the needs of their patients.

  15. Large Format Uncooled Focal Plane Array Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Uncooled focal plane arrays have improved dramatically and array sizes of 320x240 elements in a 50-?m pitch are commercially available at affordable cost. Black...

  16. Causal inheritence in plane wave quotients

    Energy Technology Data Exchange (ETDEWEB)

    Hubeny, Veronika E.; Rangamani, Mukund; Ross, Simon F.

    2003-11-24

    We investigate the appearance of closed timelike curves in quotients of plane waves along spacelike isometries. First we formulate a necessary and sufficient condition for a quotient of a general spacetime to preserve stable causality. We explicitly show that the plane waves are stably causal; in passing, we observe that some pp-waves are not even distinguishing. We then consider the classification of all quotients of the maximally supersymmetric ten-dimensional plane wave under a spacelike isometry, and show that the quotient will lead to closed timelike curves iff the isometry involves a translation along the u direction. The appearance of these closed timelike curves is thus connected to the special properties of the light cones in plane wave spacetimes. We show that all other quotients preserve stable causality.

  17. Titanium Heat Pipe Thermal Plane Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Thermacore Inc. proposes an innovative titanium heat pipe thermal plane for passive thermal control of individual cells within a fuel cell stack. The proposed...

  18. Titanium Heat Pipe Thermal Plane Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of the Phase II program is to complete the development of the titanium heat pipe thermal plane and establish all necessary steps for production of this...

  19. Equivalent boundary integral equations for plane elasticity

    Institute of Scientific and Technical Information of China (English)

    胡海昌; 丁皓江; 何文军

    1997-01-01

    Indirect and direct boundary integral equations equivalent to the original boundary value problem of differential equation of plane elasticity are established rigorously. The unnecessity or deficiency of some customary boundary integral equations is indicated by examples and numerical comparison.

  20. Linear connections on the quantum plane

    CERN Document Server

    Dubois-Violette, M; Masson, T; Mourad, J; Dubois-Violette, Michel; Madore, John; Masson, Thierry; Mourad, Jihad

    1994-01-01

    A general definition has been proposed recently of a linear connection and a metric in noncommutative geometry. It is shown that to within normalization there is a unique linear connection on the quantum plane and there is no metric.

  1. Parallels plane projection and its geometric features

    Institute of Scientific and Technical Information of China (English)

    ZHOU ChengHu; MA Ting; YANG Liao; QIN Biao

    2007-01-01

    A new equivalent map projection called the parallels plane projection is proposed in this paper. The transverse axis of the parallels plane projection is the expansion of the equator and its vertical axis equals half the length of the central meridian. On the parallels plane projection, meridians are projected as sine curves and parallels are a series of straight, parallel lines. No distortion of length occurs along the central meridian or on any parallels of this projection. Angular distortion and the proportion of length along meridians (except the central meridian) introduced by the projection transformation increase with increasing longitude and latitude. A potential application of the parallels plane projection is that it can provide an efficient projection transformation for global discrete grid systems.

  2. Metrics and causality on Moyal planes

    CERN Document Server

    Franco, Nicolas

    2015-01-01

    Metrics structures stemming from the Connes distance promote Moyal planes to the status of quantum metric spaces. We discuss this aspect in the light of recent developments, emphasizing the role of Moyal planes as representative examples of a recently introduced notion of quantum (noncommutative) locally compact space. We move then to the framework of Lorentzian noncommutative geometry and we examine the possibility of defining a notion of causality on Moyal plane, which is somewhat controversial in the area of mathematical physics. We show the actual existence of causal relations between the elements of a particular class of pure (coherent) states on Moyal plane with related causal structure similar to the one of the usual Minkowski space, up to the notion of locality.

  3. Faddeev Null Plane Model of Proton

    CERN Document Server

    D'Araújo, W R B; Frederico, T

    1998-01-01

    The proton is formulated as a relativistic system of three constituent quarks interacting via a zero-range two-body force in the null-plane. The covariance of the null-plane Faddeev-like equation under kinematical front-form boosts is discussed. A simplified three-boson model of the nucleon wave-function is obtained numerically. The proton electric form-factor reproduces the experimental data for low momentum transfers and qualitatively describes the asymptotic region.

  4. Ostrowski Type Inequalities in the Grushin Plane

    Directory of Open Access Journals (Sweden)

    Liu Heng-Xing

    2010-01-01

    Full Text Available Motivated by the work of B.-S. Lian and Q.-H. Yang (2010 we proved an Ostrowski inequality associated with Carnot-Carathéodory distance in the Grushin plane. The procedure is based on a representation formula. Using the same representation formula, we prove some Hardy type inequalities associated with Carnot-Carathéodory distance in the Grushin plane.

  5. Deep-Plane Lipoabdominoplasty in East Asians

    OpenAIRE

    Kim, June-kyu; Jang, Jun-Young; Hong, Yoon Gi; Sim, Hyung Bo; Sun, Sang Hoon

    2016-01-01

    Background The objective of this study was to develop a new surgical technique by combining traditional abdominoplasty with liposuction. This combination of operations permits simpler and more accurate management of various abdominal deformities. In lipoabdominoplasty, the combination of techniques is of paramount concern. Herein, we introduce a new combination of liposuction and abdominoplasty using deep-plane flap sliding to maximize the benefits of both techniques. Methods Deep-plane lipoa...

  6. Deep plane facelifting for facial rejuvenation.

    Science.gov (United States)

    Gordon, Neil; Adam, Stewart

    2014-08-01

    The purpose of this article is to provide the facial plastic surgeon with anatomical and embryologic evidence to support the use of the deep plane technique for optimal treatment of facial aging. A detailed description of the procedure is provided to allow safe and consistent performance. Insights into anatomical landmarks, technical nuances, and alternative approaches for facial variations are presented. The following points will be further elucidated in the article. The platysma muscle/submuscular aponeurotic system/galea are the continuous superficial cervical fascia encompassing the majority of facial fat, and this superficial soft tissue envelope is poorly anchored to the face. The deep cervical fascia binds the structural aspects of the face and covers the facial nerve and buccal fat pad. Facial aging is mainly due to gravity's long-term effects on the superficial soft tissue envelope, with more subtle effects on the deeper structural compartments. The deep plane is the embryologic cleavage plane between these fascial layers, and is the logical place for facial dissection. The deep plane allows access to the buccal fat pad for treatment of jowling. Soft tissue mobilization is maximized in deep plane dissections and requires careful hairline planning. Flap advancement creates tension only at the fascia level allowing natural, tension-free skin closure, and long-lasting outcomes. The deep plane advancement flap is well vascularized and resistant to complications.

  7. Magnitude of the carbon isotope excursion at the Paleocene Eocene thermal maximum: The role of plant community change

    Science.gov (United States)

    Smith, Francesca A.; Wing, Scott L.; Freeman, Katherine H.

    2007-10-01

    Carbon-isotope measurements ( δ13C) of leaf-wax n-alkanes from the Paleocene-Eocene Thermal Maximum (PETM) in the Bighorn Basin, Wyoming, reveal a negative carbon isotope excursion (CIE) of 4-5‰, which is 1-2‰ larger than that observed in marine carbonate δ13C records. Reconciling these records requires either that marine carbonates fail to record the full magnitude of the CIE or that the CIE in plants has been amplified relative to the marine. Amplification of the CIE has been proposed to result from an increase in available moisture that allowed terrestrial plants to increase 13C-discrimination during the PETM. Leaf physiognomy, paleopedology and hydrogen isotope ratios of leaf-wax lipids from the Bighorn Basin, however, all suggest that rather than a simple increase in available moisture, climate alternated between wet and dry during the PETM. Here we consider two other explanations and test them quantitatively with the carbon isotopic record of plant lipids. The "marine modification" hypothesis is that the marine carbonate record was modified by chemical changes at the PETM and that plant lipids record the true magnitude of the CIE. Using atmospheric CO 2δ13C values estimated from the lipid record, and equilibrium fractionation between CO 2 and carbonate, we estimate the expected CIE for planktonic foraminifera to be 6‰. Instead, the largest excursion observed is about 4‰. No mechanism for altering marine carbonate by 2‰ has been identified and we thus reject this explanation. The "plant community change" hypothesis is that major changes in floral composition during the PETM amplified the CIE observed in n-alkanes by 1-2‰ relative to marine carbonate. This effect could have been caused by a rapid transition from a mixed angiosperm/conifer flora to a purely angiosperm flora. The plant community change hypothesis is consistent with both the magnitude and pattern of CIE amplification among the different n-alkanes, and with data from fossil plants

  8. Rock Magnetic Cyclostratigraphy of the Edicaran Doushantuo Formation, South China: Determining the Duration of the Shuram Carbon Isotope Excursion

    Science.gov (United States)

    Gong, Z.; Kodama, K. P.; Li, Y. X.

    2015-12-01

    To determine the duration of the Shuram carbon-isotope excursion (SE), we conducted paleomagnetic, rock magnetic, and carbon isotopic studies of the Ediacaran Doushantuo Formation at the Dongdahe-Feidatian section near Chengjiang in South China. Zhu et al. (2007)1 indicate that the SE is 97.4 ± 9.5 m thick at this locality. The SE may record the oxidation of the ocean just before the Cambrian explosion. We collected unoriented samples for rock magnetic cyclostratigraphy at 10 cm intervals for 68 m of the Dongdahe section and 101 oriented cores at 2-3 m intervals for paleomagnetism. Comparing our carbon isotope measurements, made on chips from the cores, to Zhu et al.'s previous work shows that the Dongdahe section records 70% of the excursion. The paleomagnetic samples were alternating field and thermally demagnetized, but were totally remagnetized in the present day geomagnetic field (D=358˚, I=38˚). Multi-taper method spectral analysis of the mass-normalized susceptibility of the 600 unoriented samples revealed six strong spectral peaks that rose above the 95% confidence limits of the robust red noise. The stratigraphic thickness of these cycles is 410, 89.3, 32.5, 27.6, 22.1 and 20.9 cm. A smaller peak with a wavelength of 110 cm was also observed. Based on the ratios of these wavelengths we interpret them to be astronomically-forced. If the 410 cm peak is set to long eccentricity (405 kyr), then the other peaks yield near-Milankovitch periods of short eccentricity (109 and 88 kyr), obliquity (32 and 27 kyr), and precession (22 and 21 kyr). A strong peak with a wavelength of 1710 cm was also observed, but is not interpreted to be orbitally-forced. The sediment accumulation rate for the Dongdahe section is 1 cm/kyr making the duration of the SE in South China 9.74 ± 0.95 Myr, in excellent agreement with estimates from Australia and California, thus supporting a primary origin for the SE and possibly the cause of the Cambrian explosion. 1PPP 254 7-61

  9. Meal sequence and glucose excursion, gastric emptying and incretin secretion in type 2 diabetes: a randomised, controlled crossover, exploratory trial.

    Science.gov (United States)

    Kuwata, Hitoshi; Iwasaki, Masahiro; Shimizu, Shinobu; Minami, Kohtaro; Maeda, Haruyo; Seino, Susumu; Nakada, Koji; Nosaka, Chihiro; Murotani, Kenta; Kurose, Takeshi; Seino, Yutaka; Yabe, Daisuke

    2016-03-01

    Investigation of dietary therapy for diabetes has focused on meal size and composition; examination of the effects of meal sequence on postprandial glucose management is limited. The effects of fish or meat before rice on postprandial glucose excursion, gastric emptying and incretin secretions were investigated. The experiment was a single centre, randomised controlled crossover, exploratory trial conducted in an outpatient ward of a private hospital in Osaka, Japan. Patients with type 2 diabetes (n = 12) and healthy volunteers (n = 10), with age 30-75 years, HbA1c 9.0% (75 mmol/mol) or less, and BMI 35 kg/m(2) or less, were randomised evenly to two groups by use of stratified randomisation, and subjected to meal sequence tests on three separate mornings; days 1 and 2, rice before fish (RF) or fish before rice (FR) in a crossover fashion; and day 3, meat before rice (MR). Pre- and postprandial levels of glucose, insulin, C-peptide and glucagon as well as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide were evaluated. Gastric emptying rate was determined by (13)C-acetate breath test involving measurement of (13)CO2 in breath samples collected before and after ingestion of rice steamed with (13)C-labelled sodium acetate. Participants, people doing measurements or examinations, and people assessing the outcomes were not blinded to group assignment. FR and MR in comparison with RF ameliorated postprandial glucose excursion (AUC-15-240 min-glucose: type 2 diabetes, FR 2,326.6 ± 114.7 mmol/l × min, MR 2,257.0 ± 82.3 mmol/l × min, RF 2,475.6 ± 87.2 mmol/l × min [p Meal sequence can play a role in postprandial glucose control through both delayed gastric emptying and enhanced incretin secretion. Our findings provide clues for medical nutrition therapy to better prevent and manage type 2 diabetes. UMIN Clinical Trials Registry UMIN000017434. Japan Society for Promotion of Science, Japan Association for

  10. Left Ventricular Systolic Function Changes in Primary Hypertension Patients Detected by the Strain of Different Myocardium Layers.

    Science.gov (United States)

    Huang, Jun; Yan, Zi-Ning; Rui, Yi-Fei; Fan, Li; Shen, Dan; Chen, Dong-Liang

    2016-01-01

    This study investigated left ventricular (LV) systolic dysfunction associated with differential strain among myocardial layers in primary hypertension (PH) patients with or without LV hypertrophy (LVH), and normal patients.In 63 PH and 42 healthy patients, two-dimensional speckle tracking echocardiography was used to measure the peak systolic longitudinal and circumferential strain of the myocardial subendocardial, middle and subepicardial layers, and the peak systolic radial strain. To assess LV systolic function, the apical long axis, 4- and 2-chamber views, and parasternal short axis at the basal, middle, and apical levels were acquired by cardiovascular ultrasound (Vivid E9, GE Healthcare, USA).Overall, the pattern in peak systolic longitudinal strain among myocardial layers was subendocardial > middle > subepicardial. In the peak systolic circumferential strain, this was middle > subepicardial > subendocardial. The peak systolic longitudinal strain was normal > NLVH > LVH. Among the groups, the peak systolic circumferential strain at the basal parasternal short-axis level was statistically similar, but at the middle and the apical parasternal short-axis levels were NLVH > normal > LVH. In normal and NLVH patients, the peak radial strain was middle > apical > basal, and in LVH patients was apical > middle > basal. The peak averages of the longitudinal and subendocardial circumferential strains differed significantly when LVH compared with NLVH and normal patients.The systolic function of PH patients was damaged in comparison with normal individuals, which could be detected conveniently and accurately using two-dimensional speckle tracking echocardiography.

  11. Optimal Systolic Blood Pressure Target After SPRINT: Insights from a Network Meta-Analysis of Randomized Trials.

    Science.gov (United States)

    Bangalore, Sripal; Toklu, Bora; Gianos, Eugenia; Schwartzbard, Arthur; Weintraub, Howard; Ogedegbe, Gbenga; Messerli, Franz H

    2017-06-01

    The optimal on-treatment blood pressure (BP) target has been a matter of debate. The recent SPRINT trial showed significant benefits of a BP target of targets. Trial arms were grouped into 5 systolic BP target categories: 1) targets. However, the point estimate favored lower BP targets (targets (targets of target. There was a significant increase in serious adverse effects with systolic BP targets of target for the outcome of serious adverse effects. Cluster plots for combined efficacy and safety showed that a systolic BP target of target of <130 mm Hg achieved optimal balance between efficacy and safety. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Direct measured systolic pressure gradients across the aorto-iliac segment in multiple-level-obstruction arteriosclerosis

    DEFF Research Database (Denmark)

    Noer, Ivan; Praestholm, J; Tønnesen, K H

    1981-01-01

    to the angiographic findings. A consistent pressure gradient was found in the various types of arterial occlusions. In patients with occlusion of both the aorta and the iliac arteries, the systolic pressure drop was about 60% (range, 50-78%, SD 9%). The various types of iliac artery occlusions resulted in quite...... uniform systolic pressure drops of about 50% (range 35-68%, SD 9%). In contrast, the systolic pressure drop along different types of iliac stenoses showed a wide variation, ranging from a minimal drop to about 60%. The degree of stenosis on the angiogram was correlated significantly with the pressure drop...

  13. Thermal Model for a Mars Instrument with Thermo-electric Cooled Focal Plane

    Science.gov (United States)

    Ladner, D. R.; Martin, J. P.

    2006-04-01

    Two thermal models have been developed for a low mass (1.5 kg) Mars rover arm candidate instrument that employs a thermoelectric cooler (TEC) to cool a CCD focal plane. The Mineral Identification and Composition Analyzer (MICA) is a miniature instrument that employs X-ray scattering and visual imaging to determine nondestructively the mineralogy of a rock sample in-situ. Both thermal models incorporate the key components of MICA's CCD subsystem - CCD, heat sink, and lower radiator. The System Model includes the instrument's internal heat sources, including electronics, X-ray source, TEC dissipation, and the extreme diurnal temperature excursions of the ambient Martian atmosphere (~175 K to 255 K) and sky (~130 K to 200 K), convection (wind), and solar / IR radiation. The CCD Subsystem Model includes a passive thermal switch that provides heat sink cool-down by night and isolation by day. With or without the heat switch, TEC operation provides extended life for data collection at the upper end of the CCD operating range, ~ 208 K. Model parameter variation allows the instrument designer to optimize thermal capacities, thermal resistances, and internal heater power to hold critical electronics and mechanical components within their temperature operating limits. The charting feature of either model provides mechanical design guidance to ensure acceptable conditions for data collection over the experiment timeline.

  14. The ability of modified star excursion balance test to differentiate between women athletes with and without chronic ankle instability

    Directory of Open Access Journals (Sweden)

    Asma Razeghi

    2016-05-01

    Full Text Available The Star Excursion Balance Test (SEBT is one functional clinical test that widely used to assess dynamic balance in patients with ankle injuries. Since the ability of this test to detect impairments between athletes with and without chronic ankle instability(CAI is not clear, the aim of present study was to determine if the modified SEBT could detect reach deficits in patients with unilateral CAI. A convenience sample of thirty elite and sub elite women athletes were selected and assigned into two groups: CAI group (Mean ± SD: age: 25±3.5 years; height: 1.68±0.09 m; weight: 62.7±7.3kg, and healthy controls (Mean ± SD: age: 26±4.2 years; height: 1.69±0.05 m; weigh t: 62.7±7.3 kg.The dynamic balance test was obtained using modified SEBT from both limbs of each participant. The independent sample t-test was used for both between group and within group inter-limb comparisons. There was no significant difference in any directions of modified SEBT between two groups in both limbs. No significant interlimb differences were also observed within both groups. The modified SEBT may not enough sensitive to differentiate between athletes with and without CAI. Other factors such as ankle range of motion, muscle strength and pain intensity should be considered for better interpretation of the SEBT results.

  15. NASA's Habitat Demonstration Unit (HDU) Pressurized Excursion Module (PEM) In-Field Demonstration at Desert RATS 2010

    Science.gov (United States)

    Tri, Terry O.; Kennedy, Kriss J.; Toups, Larry; Gill, Tracy R.; Howe, A. Scott

    2011-01-01

    This paper describes the construction, assembly, subsystem integration, transportation, and field testing operations associated with the Habitat Demonstration Unit (HDU) Pressurized Excursion Module (PEM) and discusses lessons learned. In a one-year period beginning summer 2009, a tightly scheduled design-develop-build process was utilized by a small NASA "tiger team" to produce the functional HDU-PEM prototype in time to participate in the 2010 Desert Research and Technology Studies (Desert RATS) field campaign. The process required the coordination of multiple teams, subcontractors, facility management and safety staff. It also required a well-choreographed material handling and transportation process to deliver the finished product from the NASA-Johnson Space Center facilities to the remote Arizona desert locations of the field test. Significant findings of this paper include the team s greater understanding of the HDU-PEM s many integration issues and the in-field training the team acquired which will enable the implementation of the next-generation of improvements and development of high-fidelity field operations in a harsh environment. The Desert RATS analog environment is being promoted by NASA as an efficient means to design, build, and integrate multiple technologies in a mission architecture context, with the eventual goal of evolving the technologies into robust flight hardware systems. The HDU-PEM in-field demonstration at Desert RATS 2010 provided a validation process for the integration team, which has already begun to retool for the 2011 field tests that require an adapted architecture.

  16. Evaluation of Postprandial Glucose Excursion Using a Novel Minimally Invasive Glucose Area-Under-the-Curve Monitoring System

    Directory of Open Access Journals (Sweden)

    Sachi Kuranuki

    2013-01-01

    Full Text Available Objective: To develop a minimally invasive interstitial fluid extraction technology (MIET to monitor postprandial glucose area under the curve (AUC without blood sampling, we evaluated the accuracy of glucose AUC measured by MIET and compared with that by blood sampling after food intake. Methods: Interstitial fluid glucose AUC (IG-AUC following consumption of 6 different types of foods was measured by MIET. MIET consisted of stamping microneedle arrays, placing hydrogel patches on the areas, and calculating IG-AUC based on glucose levels in the hydrogels. Glycemic index (GI was determined using IG-AUC and reference AUC measured by blood sampling. Results: IG-AUC strongly correlated with reference AUC (R = 0.91, and GI determined using IG-AUC showed good correlation with that determined by reference AUC (R = 0.88. Conclusions: IG-AUC obtained by MIET can accurately predict the postprandial glucose excursion without blood sampling. In addition, feasibility of GI measurement by MIET was confirmed.

  17. Relationship between the TMJ disc and condyle position on MRI and occlusal contacts on lateral excursions in TMD patients.

    Science.gov (United States)

    Taşkaya-Yilmaz, N; Oğütcen-Toller, M; Saraç, Y S

    2004-08-01

    Confusion about the relationship between dental occlusion and the temporomandibular disorders (TMD) has been evident in the literature for many years. Previous studies have supported the concept of a multifactorial aetiology of TMD, the occlusal factor in general being of minor importance. The purpose of the study was to investigate the relationship between condyle and disc positions and occlusal contacts on lateral excursions of the mandible in patients with TMD. A total of 122 temporomandibular joints (TMJs) of 61 patients with TMD were evaluated using magnetic resonance imaging (MRI) and occlusal analyses were made clinically. Non-working-side contacts were found to be statistically significant in TMJ anterior disc displacement. No significant statistical correlation was found between the severity of anterior disc displacement and non-working-side contacts in both canine guidance and group function occlusions. There was no correlation between non-working-side contacts and condyle positions in both occlusion types in the present study. It was concluded that non-working-side contacts had some effect on disc position in TMD, however the presence of these contacts in both canine guidance and group function occlusions did not correlate with anterior disc displacement in TMD statistically. Therefore, non-working-side contacts are not to be regarded as the prime cause of anterior disc displacement.

  18. Oxygen-isotope trends and seawater temperature changes across the Late Cambrian Steptoean positive carbon-isotope excursion (SPICE event)

    Science.gov (United States)

    Elrick, M.; Rieboldt, S.; Saltzman, M.; McKay, R.M.

    2011-01-01

    The globally recognized Late Cambrian Steptoean positive C-isotope excursion (SPICE) is characterized by a 3???-5??? positive ??13C shift spanning SPICE represents a widespread ocean anoxic event leading to enhanced burial/preservation of organic matter (Corg) and pyrite. We analyzed ??18O values of apatitic inarticulate brachiopods from three Upper Cambrian successions across Laurentia to evaluate paleotemperatures during the SPICE. ??18O values range from ~12.5??? to 16.5???. Estimated seawater temperatures associated with the SPICE are unreasonably warm, suggesting that the brachiopod ??18O values were altered during early diagenesis. Despite this, all three localities show similar trends with respect to the SPICE ??13C curve, suggesting that the brachiopod apatite preserves a record of relative ??18O and temperature changes. The trends include relatively high ??18O values at the onset of the SPICE, decreasing and lowest values during the main event, and an increase in values at the end of the event. The higher ??18O values during the global extinction at the onset of the SPICE suggests seawater cooling and supports earlier hypotheses of upwelling of cool waters onto the shallow shelf. Decreasing and low ??18O values coincident with the rising limb of the SPICE support the hypothesis that seawater warming and associated reduced thermohaline circulation rates contributed to decreased dissolved O2 concentrations, which enhanced the preservation/burial of Corg causing the positive ??13C shift. ?? 2011 Geological Society of America.

  19. Relationship between the modified star excursion balance test and the 4x10 m shuttle run test in children

    Directory of Open Access Journals (Sweden)

    Joaquín Calatayud

    2017-01-01

    Full Text Available Resumen La agilidad y el equilibrio dinámico son habilidades cruciales en la actividad física prepuberal y la participación deportiva, por lo tanto es necesaria la identificación de pruebas eficientes para su evaluación. Evaluar la correlación entre la agilidad y el equilibrio dinámico en niños escolares de primaria. Veintisiete niños y veinte niñas de 10 años participaron voluntariamente en el estudio. El Star Excursion Balance Test (SEBT modificado y el 4x10 m Shuttle Run Test se utilizaron respectivamente para evaluar el equilibrio dinámico y agilidad. Las puntuaciones compuestas del equilibrio dinámico con apoyo diestro mostraron solo entre los niños una moderada correlación significativa (r = -0.51, p < 0.05 con la prueba de agilidad. Sin embargo, entre las niñas se mostró una correlación significativa (r = -0.45, p < 0.05 durante la distancia de alcance posterolateral obtenida en el SEBT. La realización del test completo o de las distancias alcanzadas a nivel posteromedial y posterolateral del SEBT se asocia moderadamente con la agilidad entre los niños, mientras que la distancia posterolateral se asocia con la agilidad entre las niñas.

  20. GLAMER Part II: Multiple Plane Gravitational Lensing

    CERN Document Server

    Petkova, Margarita; Giocoli, Carlo

    2013-01-01

    We present an extension to multiple planes of the gravitational lensing code {\\small GLAMER}. The method entails projecting the mass in the observed light-cone onto a discrete number of lens planes and inverse ray-shooting from the image to the source plane. The mass on each plane can be represented as halos, simulation particles, a projected mass map extracted form a numerical simulation or any combination of these. The image finding is done in a source oriented fashion, where only regions of interest are iteratively refined on an initially coarse image plane grid. The calculations are performed in parallel on shared memory machines. The code is able to handle different types of analytic halos (NFW, NSIE, power-law, etc.), haloes extracted from numerical simulations and clusters constructed from semi-analytic models ({\\small MOKA}). Likewise, there are several different options for modeling the source(s) which can be distributed throughout the light-cone. The distribution of matter in the light-cone can be e...

  1. GLAMER - II. Multiple-plane gravitational lensing

    Science.gov (United States)

    Petkova, Margarita; Metcalf, R. Benton; Giocoli, Carlo

    2014-12-01

    We present an extension to multiple planes of the gravitational lensing code GLAMER. The method entails projecting the mass in the observed light-cone on to a discrete number of lens planes and inverse ray-shooting from the image to the source plane. The mass on each plane can be represented as haloes, simulation particles, a projected mass map extracted form a numerical simulation or any combination of these. The image finding is done in a source-oriented fashion, where only regions of interest are iteratively refined on an initially coarse image plane grid. The calculations are performed in parallel on shared memory machines. The code is able to handle different types of analytic haloes (NFW, NSIE, power law, etc.), haloes extracted from numerical simulations and clusters constructed from semi-analytic models (MOKA). Likewise, there are several different options for modelling the source(s) which can be distributed throughout the light-cone. The distribution of matter in the light-cone can be either taken from a pre-existing N-body numerical simulations, from halo catalogues, or are generated from an analytic mass function. We present several tests of the code and demonstrate some of its applications such as generating mock images of galaxy and galaxy cluster lenses.

  2. Efficacy of combination therapy with amlodipine besylate/benazepril hydrochloride for lowering systolic blood pressure in stage 2 hypertension.

    Science.gov (United States)

    Neutel, Joel M; Smith, David H G; Weber, Michael A; Schofield, Lesley; Purkayastha, Das; Gatlin, Marjorie

    2006-01-01

    The Systolic Evaluation of Lotrel Efficacy and Comparative Therapies (SELECT) study compared daily treatment with combination amlodipine besylate/benazepril hydrochloride 5/20 mg, amlodipine besylate 5 mg, and benazepril hydrochloride 20 mg in 505 patients aged 55 years of age or older with stage 2 hypertension (systolic blood pressure [BP] > or =160 and or =60 and < or =100 mm Hg). BP and pulse pressure were assessed by conventional office BP measurements and 24-hour ambulatory BP monitoring. In this analysis, combination therapy was associated with significantly greater reductions in mean 24-hour BP, pulse pressure, and mean ambulatory BP during various time intervals compared with either monotherapy in the intent-to-treat population, in those with isolated and predominantly systolic hypertension, and in dippers and nondippers. Adverse event rates were low and similar in all treatment groups. This study demonstrated that combination therapy is superior to monotherapy in older patients with stage 2 systolic hypertension and is well tolerated.

  3. Exercise Training for Heart Failure Patients with and without Systolic Dysfunction: An Evidence-Based Analysis of How Patients Benefit

    Directory of Open Access Journals (Sweden)

    Neil Smart

    2011-01-01

    Full Text Available Significant benefits can be derived by heart failure patients from exercise training. This paper provides an evidence-based assessment of expected clinical benefits of exercise training for heart failure patients. Meta-analyses and randomized, controlled trials of exercise training in heart failure patients were reviewed from a search of PubMed, Cochrane Controlled Trial Registry (CCTR, CINAHL, and EMBASE. Exercise training improves functional capacity, quality of life, hospitalization, and systolic and diastolic function in heart failure patients. Heart failure patients with preserved systolic function (HFnEF participating in exercise training studies are more likely to be women and are 5–7 years older than their systolic heart failure (CHF counterparts. All patients exhibit low functional capacities, although in HFnEF patients this may be age related, therefore subtle differences in exercise prescriptions are required. Published works report that exercise training is beneficial for heart failure patients with and without systolic dysfunction.

  4. Congestive heart failure with preserved left ventricular systolic function after acute myocardial infarction: clinical and prognostic implications

    DEFF Research Database (Denmark)

    Møller, Jacob Eifer; Brendorp, Bente; Ottesen, Michael;

    2003-01-01

    AIMS: To characterise the prevalence, in-hospital complications, management, and long-term outcome of patients with congestive heart failure but preserved left ventricular systolic function after acute myocardial infarction. METHODS: 3166 consecutive patients screened for entry in the Bucindolol...... and all cause mortality. RESULTS: Congestive heart failure was seen during hospitalisation in 1464 patients (46%), 717 patients had preserved left ventricular systolic function (wall motion index > or =1.3 corresponding to ejection fraction > or =0.40), and 732 patients had systolic dysfunction (wall.......3 (95% CI 2.8-4.0), and after adjustment for baseline characteristics and left ventricular systolic function in multivariate Cox proportional hazards analysis the risk was 2.1 (95% CI 1.7-2.6), PCongestive heart failure is frequently present in patients with preserved left...

  5. Anaemia is an independent predictor of mortality in patients with left ventricular systolic dysfunction following acute myocardial infarction

    DEFF Research Database (Denmark)

    Valeur, Nana; Nielsen, Olav Wendelboe; McMurray, John J V;

    2006-01-01

    BACKGROUND: In patients with chronic heart failure (HF), mortality is inversely related to haemoglobin (hgb) concentration. We investigated the prognostic importance of anaemia in patients with acute myocardial infarction (AMI) and left ventricular systolic dysfunction (LVSD) with and without HF...

  6. Synchronicity of systolic deformation in healthy pediatric and young adult subjects: a two-dimensional strain echocardiography study.

    NARCIS (Netherlands)

    Marcus, K.A.; Janousek, J.; Barends, M.E.; Weijers, G.; Korte, C.L. de; Kapusta, L.

    2012-01-01

    Two-dimensional speckle tracking echocardiography (2DSTE) offers valuable information in the echocardiographic assessment of ventricular myocardial function. It enables the quantification and timing of systolic ventricular myocardial deformation. In addition, 2DSTE can be used to identify mechanical

  7. Role of two dimensional strain and strain rate imaging in assessment of left ventricular systolic function in patients with rheumatic mitral stenosis and normal ejection fraction

    Directory of Open Access Journals (Sweden)

    Hany Younan

    2015-09-01

    Conclusion: Patients with MS and preserved EF% had lower 2D longitudinal LV systolic S and Sr compared to the control group. 2D longitudinal LV systolic S and Sr imaging appears to be useful in the detection of subclinical LV systolic dysfunction in patients with MS and preserved EF%.

  8. Finnish–Hungarian Cooperation in Bryology; Memories from Excursions, Congresses and Research with Professor Tamás Pócs

    Directory of Open Access Journals (Sweden)

    Koponen Timo

    2013-07-01

    Full Text Available The paper describes Professor Tamás Pócs’ cooperation with Finnish bryologists and other cryptogam taxonomists. Cooperation began with exchange of reprints in 1966 and identification of African bryophyte specimens in 1973. In 1976, Timo Koponen visited Budapest and Eger, and joint work continued during a University of Helsinki Department of Botany student excursion to Tanzania in 1988. Tamás Pócs, then a professor at Sokoine Agricultural University, arranged the logistics for the preparatory visit of four teachers as well as for the excursion itself. Later, Pócs participated in the Congress of Eastern Asiatic Bryology, the EU-funded ‘Advanced instruction in bryology and lichenology’ (Large Scale Facility program and the ‘Bryophyte Flora of the Huon Peninsula, Papua New Guinea’ project organized in Helsinki. He was elected a corresponding member of the Finnish Bryological Society in 2009.

  9. Star excursion balance test for assessment of dynamic instability of the ankle in patients after harvest of a fibular free flap: a two-centre study.

    Science.gov (United States)

    Shah, K C; Peehal, J P; Shah, A; Crank, S; Flora, H S

    2017-04-01

    We aimed to show that the star excursion balance test can identify instability in the ankle of patients who have had harvest of a fibular free flap. We compared the reach distance of the operated leg against that of the non-operated leg in 26 patients who had had harvest of the flap over a period of three years from August 2009 at two different centres. The goal of the test is to reach as far as possible with one leg in eight directions while balancing on the other. We also assessed the overall function of the operated leg using the Foot and Ankle Disability Index (FADI) and the American Orthopaedic Foot and Ankle Score (AOFAS). The star excursion balance test is simple and cheap, and is quick and easy to do in the outpatient department.

  10. A Miniature Robotic Plane Meteorological Sounding System

    Institute of Scientific and Technical Information of China (English)

    马舒庆; 陈洪滨; 汪改; 潘毅; 李强

    2004-01-01

    This article presents a miniature robotic plane meteorological sounding system RPMSS), which consists of three major subsystems: a miniature robotic plane, an air-borne meteorological sounding and flight control system, and a ground-based system. Take-off and landing of the miniature aircraft are guided by radio control, and the flight of the robotic plane along a pre-designed trajectory is automatically piloted by an onboard navigation system. The observed meteorological data as well as all flight information are sent back in real time to the ground, then displayed and recorded by the ground-based computer. The ground-based subsystem can also transmit instructions to the air-borne control subsystem. Good system performance has been demonstrated by more than 300 hours of flight for atmospheric sounding.

  11. The horizontal plane appearances of scoliosis

    DEFF Research Database (Denmark)

    Illés, Tamás S.; Burkus, Máté; Somoskeőy, Szabolcs

    2017-01-01

    Purpose: A posterior-anterior vertebral vector is proposed to facilitate visualization and understanding of scoliosis. The aim of this study was to highlight the interest of using vertebral vectors, especially in the horizontal plane, in clinical practice. Methods: We used an EOS two-/three-dimen......Purpose: A posterior-anterior vertebral vector is proposed to facilitate visualization and understanding of scoliosis. The aim of this study was to highlight the interest of using vertebral vectors, especially in the horizontal plane, in clinical practice. Methods: We used an EOS two...... of scoliosis. The approach used is simple. These results are sufficient for a first visual analysis furnishing significant clinical information in all three anatomical planes. This visualization represents a reasonable compromise between mathematical purity and practical use....

  12. Optimal plane change by low aerodynamic forces

    Science.gov (United States)

    Vinh, Nguyen X.; Ma, Der-Ming

    1990-01-01

    This paper presents the exact dimensionless equations of motion and the necessary conditions for the computation of the optimal trajectories of a hypervelocity vehicle flying through a nonrotating spherical planetary atmosphere. It is shown that there are two types of maneuvers with nearly identical plane change. In the hard maneuver, the vehicle is pulled down to low altitude for aerodyamic plane change before exit at the prescribed final speed. In the slow maneuver which is described in detail in this paper, the vehicle remains in orbital flight with a small incremental plane change during each passage through the perigee. This maneuver requires several revolutions, and the technique for computation is similar to that in the problem of contraction of orbit.

  13. Are rotating planes of satellite galaxies ubiquitous?

    CERN Document Server

    Phillips, John I; Bullock, James S; Boylan-Kolchin, Michael

    2015-01-01

    We compare the dynamics of satellite galaxies in the Sloan Digital Sky Survey to simple models in order to test the hypothesis that a large fraction of satellites co-rotate in coherent planes. We confirm the previously-reported excess of co-rotating satellite pairs located near diametric opposition with respect to the host, but show that this signal is unlikely to be due to rotating discs (or planes) of satellites. In particular, no overabundance of co-rotating satellites pairs is observed within $\\sim 20^{\\circ}-50^{\\circ}$ of direct opposition, as would be expected for planar distributions inclined relative to the line-of-sight. Instead, the excess co-rotation for satellite pairs within $\\sim 10^{\\circ}$ of opposition is consistent with random noise associated with undersampling of an underlying isotropic velocity distribution. We conclude that at most $10\\%$ of the hosts in our sample harbor co-rotating satellite planes (as traced by the luminous satellite population).

  14. Solid-state curved focal plane arrays

    Science.gov (United States)

    Nikzad, Shouleh (Inventor); Hoenk, Michael (Inventor); Jones, Todd (Inventor)

    2010-01-01

    The present invention relates to curved focal plane arrays. More specifically, the present invention relates to a system and method for making solid-state curved focal plane arrays from standard and high-purity devices that may be matched to a given optical system. There are two ways to make a curved focal plane arrays starting with the fully fabricated device. One way, is to thin the device and conform it to a curvature. A second way, is to back-illuminate a thick device without making a thinned membrane. The thick device is a special class of devices; for example devices fabricated with high purity silicon. One surface of the device (the non VLSI fabricated surface, also referred to as the back surface) can be polished to form a curved surface.

  15. Systolic reconstruction in patients with low heart rate using coronary dual-source CT angiography

    Energy Technology Data Exchange (ETDEWEB)

    Okada, Munemasa, E-mail: radokada@yamaguchi-u.ac.jp [Department of Radiology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505 (Japan); Nakashima, Yoshiteru; Shigemoto, Youko; Matsunaga, Naofumi [Department of Radiology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505 (Japan); Miura, Toshiro; Nao, Tomoko [Department of Cardiology, Yamaguchi University Graduate School of Medicine (Japan); Sano, Yuichi; Narazaki, Akiko [Department of Radiology, Yamaguchi University Hospital (Japan); Kido, Shoji [Computer-aided Diagnosis and Biomedical Imaging Research Biomedical Engineering, Applied Medical Engineering Science Graduate School of Medicine, Yamaguchi University (Japan)

    2011-11-15

    Objectives: The purpose of our study was to determine the relationship between the predictive factors and systolic reconstruction (SR) as an optimal reconstruction window in patients with low heart rate (LHR; less than 65 bpm). Methods: 391 patients (262 male and 129 female, mean age; 67.1 {+-} 10.1 years of age) underwent coronary CTA without the additional administration of a beta-blocker. Affecting factors for SR were analyzed in age, gender, body weight (BW), diabetes mellitus (DM), coronary arterial disease (CAD), ejection fraction (EF), systolic and diastolic body pressure (BP) and heart rate variability (HRV) during coronary CTA. Results: In 29 (7.4%) of the 391 patients, SR was needed, but there was no apparent characteristic difference between the systolic and diastolic reconstruction groups in terms of gender, age, BW, DM, CAD and EF. In a multivariate analysis, the co-existence of DM [P < 0.05; OR, 0.27; 95% CI, 0.092-0.80], diastolic BP [P < 0.01; OR, 0.95; 95% CI, 0.92-0.98] and HRV [P < 0.01; OR, 0.98; 95% CI, 0.96-0.99] were found to be the factors for SR. In gender-related analysis, HRV was an important factor regardless of sex, but co-existence of DM affected especially for female and BP for male. Conclusion: Especially in the patients with LHR who had a medication of DM, high HRV or high BP, SR, in addition to DR, was needed to obtain high-quality coronary CTA images.

  16. Cardiac I123-MIBG Correlates Better than Ejection Fraction with Symptoms Severity in Systolic Heart Failure

    Energy Technology Data Exchange (ETDEWEB)

    Miranda, Sandra M.; Moscavitch, Samuel D.; Carestiato, Larissa R. [Programa de Pós-Graduação em Ciências Cardiovasculares, Hospital Universitário Antonio Pedro, Universidade Federal Fluminense, Rio de Janeiro, RJ (Brazil); Felix, Renata M. [Departamento de Medicina Nuclear, Hospital Pró-Cardíaco, Rio de Janeiro, RJ (Brazil); Rodrigues, Ronaldo C.; Messias, Leandro R. [Programa de Pós-Graduação em Ciências Cardiovasculares, Hospital Universitário Antonio Pedro, Universidade Federal Fluminense, Rio de Janeiro, RJ (Brazil); Azevedo, Jader C. [Programa de Pós-Graduação em Ciências Cardiovasculares, Hospital Universitário Antonio Pedro, Universidade Federal Fluminense, Rio de Janeiro, RJ (Brazil); Departamento de Medicina Nuclear, Hospital Pró-Cardíaco, Rio de Janeiro, RJ (Brazil); Nóbrega, Antonio Cláudio L.; Mesquita, Evandro Tinoco [Programa de Pós-Graduação em Ciências Cardiovasculares, Hospital Universitário Antonio Pedro, Universidade Federal Fluminense, Rio de Janeiro, RJ (Brazil); Mesquita, Claudio Tinoco, E-mail: ctinocom@cardiol.br [Programa de Pós-Graduação em Ciências Cardiovasculares, Hospital Universitário Antonio Pedro, Universidade Federal Fluminense, Rio de Janeiro, RJ (Brazil); Departamento de Medicina Nuclear, Hospital Pró-Cardíaco, Rio de Janeiro, RJ (Brazil)

    2013-07-15

    The association of autonomic activation, left ventricular ejection fraction (LVEF) and heart failure functional class is poorly understood. Our aim was to correlate symptom severity with cardiac sympathetic activity, through iodine-123-metaiodobenzylguanidine ({sup 123}I-MIBG) scintigraphy and with LVEF in systolic heart failure (HF) patients without previous beta-blocker treatment. Thirty-one patients with systolic HF, class I to IV of the New York Heart Association (NYHA), without previous beta-blocker treatment, were enrolled and submitted to {sup 123}I-MIBG scintigraphy and to radionuclide ventriculography for LVEF determination. The early and delayed heart/mediastinum (H/M) ratio and the washout rate (WR) were performed. According with symptom severity, patients were divided into group A, 13 patients in NYHA class I/II, and group B, 18 patients in NYHA class III/IV. Compared with group B patients, group A had a significantly higher LVEF (25% ± 12% in group B vs. 32% ± 7% in group A, p = 0.04). Group B early and delayed H/M ratios were lower than group A ratios (early H/M 1.49 ± 0.15 vs. 1.64 ± 0.14, p = 0.02; delayed H/M 1.39 ± 0.13 vs. 1.58 ± 0.16, p = 0.001, respectively). WR was significantly higher in group B (36% ± 17% vs. 30% ± 12%, p= 0.04). The variable that showed the best correlation with NYHA class was the delayed H/M ratio (r= -0.585; p=0.001), adjusted for age and sex. This study showed that cardiac {sup 123}I-MIBG correlates better than ejection fraction with symptom severity in systolic heart failure patients without previous beta-blocker treatment.

  17. [Atrial filling fraction predicts left ventricular systolic function after myocardial infarction: pre-discharge echocardiographic evaluation].

    Science.gov (United States)

    Galderisi, M; Fakher, A; Petrocelli, A; Alfieri, A; Garofalo, M; de Divitiis, O

    1995-10-01

    Aim of the study was to examine the relation between Doppler-derived indices of left ventricular diastolic and systolic function early after myocardial infarction. Fifty-three patients (31 males, 22 females) recovering from acute myocardial infarction underwent predischarge Doppler echocardiographic examination. Patients with age > 70 years, previous myocardial infarction, more than mild mitral and aortic regurgitation, mitral and aortic stenosis were excluded. Twenty-two healthy subjects (13 males; 9 females) free of coronary risk factors were selected as the control group. Both end-diastolic and end-systolic volumes and ejection fraction were measured by two-dimensional echocardiography. Pulsed Doppler was used to evaluate mitral inflow and left ventricular outflow velocity patterns. The following indices were measured: peak velocity of early (E) and late (A) flows, ratio of E/A peak velocities, ratio of early to late time velocity integrals, atrial filling fraction (time velocity integral A / time velocity integral of flow during total diastole) and deceleration time of E wave for mitral inflow; peak and time-velocity integral for left ventricular outflow. Stroke volume and cardiac output were obtained by pulsed Doppler using the left ventricular outflow method. The two groups were comparable for age, with blood pressure (p volumes were significantly higher (both p volume and cardiac output (both p volumes, atrial filling fraction was an independent predictor of stroke volume, with a direct relation (beta coefficient = 0.53, p volume indicates the importance of atrial contribution to maintain an adequate systolic performance in patients with myocardial infarction.

  18. Echocardiographic Parameters and Survival in Chagas Heart Disease with Severe Systolic Dysfunction

    Energy Technology Data Exchange (ETDEWEB)

    Rassi, Daniela do Carmo, E-mail: dani.rassi@hotmail.com [Faculdade de Medicina e Hospital das Clínicas da Universidade Federal de Goiás (UFG), Goiânia, GO (Brazil); Vieira, Marcelo Luiz Campos [Instituto do Coração da Faculdade de Medicina da Universidade de São Paulo (USP), São Paulo, SP (Brazil); Arruda, Ana Lúcia Martins [Instituto de Radiologia da Faculdade de Medicina da Universidade de São Paulo (USP), São Paulo, SP (Brazil); Hotta, Viviane Tiemi [Instituto do Coração da Faculdade de Medicina da Universidade de São Paulo (USP), São Paulo, SP (Brazil); Furtado, Rogério Gomes; Rassi, Danilo Teixeira; Rassi, Salvador [Faculdade de Medicina e Hospital das Clínicas da Universidade Federal de Goiás (UFG), Goiânia, GO (Brazil)

    2014-03-15

    Echocardiography provides important information on the cardiac evaluation of patients with heart failure. The identification of echocardiographic parameters in severe Chagas heart disease would help implement treatment and assess prognosis. To correlate echocardiographic parameters with the endpoint cardiovascular mortality in patients with ejection fraction < 35%. Study with retrospective analysis of pre-specified echocardiographic parameters prospectively collected from 60 patients included in the Multicenter Randomized Trial of Cell Therapy in Patients with Heart Diseases (Estudo Multicêntrico Randomizado de Terapia Celular em Cardiopatias) - Chagas heart disease arm. The following parameters were collected: left ventricular systolic and diastolic diameters and volumes; ejection fraction; left atrial diameter; left atrial volume; indexed left atrial volume; systolic pulmonary artery pressure; integral of the aortic flow velocity; myocardial performance index; rate of increase of left ventricular pressure; isovolumic relaxation time; E, A, Em, Am and Sm wave velocities; E wave deceleration time; E/A and E/Em ratios; and mitral regurgitation. In the mean 24.18-month follow-up, 27 patients died. The mean ejection fraction was 26.6 ± 5.34%. In the multivariate analysis, the parameters ejection fraction (HR = 1.114; p = 0.3704), indexed left atrial volume (HR = 1.033; p < 0.0001) and E/Em ratio (HR = 0.95; p = 0.1261) were excluded. The indexed left atrial volume was an independent predictor in relation to the endpoint, and values > 70.71 mL/m{sup 2} were associated with a significant increase in mortality (log rank p < 0.0001). The indexed left atrial volume was the only independent predictor of mortality in this population of Chagasic patients with severe systolic dysfunction.

  19. Left Ventricular Regional Systolic Function in Patient with Hypertrophic Cardiomyopathy by Quantitative Tissue Velocity Imaging

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The left ventricular regional systolic functions in patients with hypertrophic cardiomyopathy (HCM) were assessed by using quantitative tissue velocity imaging (QTVI). Left ventricular (LV) regional myocardial velocity along long- and short-axis in 31 HCM patients and 20 healthy subjects were analyzed by QTVI, and the regional myocardial systolic peak velocities (MVS) were measured. Mean MVS at each level including mitral annular, basal, middle and apical segments were calculated. The ratio of MVS along long-axis to that along short-axis (Ri) at basal and middle segments of the LV posterior wall and ventricular septum were calculated. The results showed that mean MVS was slower at each level including mitral annular, basal, middle and apical segments in the HCM patients than that in the healthy subjects (P<0.01). There were no significant differences in mean MVS between obstructive and non-obstructive groups in HCM patients. MVS of all regional myocardial segments along long-axis in the HCM patients were significantly slower than that in the healthy subjects (P<0. 05), but there was no significant difference in MVS of all regional myocardial segments along long-axis between hypertrophied and non-hypertrophied group in the HCM patients. Ri was significantly lower in the HCM patients than that in the healthy subjects. The LV regional myocardial contractility along long-axis was impaired not only in the hypertrophied wall but also in the non-hypertrophied one in patients with HCM, suggesting that QTVI can assess accurately LV regional systolic function in patient with HCM and provides a novel means for an early diagnosis before and independent of hypertrophy.

  20. Reduced effect of percutaneous renal denervation on blood pressure in patients with isolated systolic hypertension.

    Science.gov (United States)

    Ewen, Sebastian; Ukena, Christian; Linz, Dominik; Kindermann, Ingrid; Cremers, Bodo; Laufs, Ulrich; Wagenpfeil, Stefan; Schmieder, Roland E; Böhm, Michael; Mahfoud, Felix

    2015-01-01

    Renal denervation can reduce blood pressure in certain patients with resistant hypertension. The effect in patients with isolated systolic hypertension (ISH, ≥140/hypertension (CH, ≥140/≥90 mm Hg) defined as baseline office systolic blood pressure (SBP) ≥140 mm Hg despite treatment with ≥3 antihypertensive agents. Renal denervation significantly reduced office SBP and diastolic blood pressure (DBP) at 3, 6, and 12 months by 17/18/17 and 5/4/4 mm Hg in ISH and by 28/27/30 and 13/16/18 mm Hg in CH, respectively. The reduction in SBP and DBP in ISH was lower compared with patients with CH at all observed time points (P<0.05 for SBP/DBP intergroup comparison). The nonresponder rate (change in office SBP <10 mm Hg) after 6 months was 37% in ISH and 21% in CH (P<0.001). Mean 24-hour ambulatory SBP and DBP after 3, 6, and 12 months were significantly reduced by 10/13/15 and 6/6/9 mm Hg in CH, respectively. In patients with ISH the reduction in systolic ambulatory blood pressure was 4/8/7 mm Hg (P=0.032/P<0.001/P=0.009) and 3/4/2 mm Hg (P=0.08/P<0.001/P=0.130) in diastolic ambulatory blood pressure after 3, 6, and 12 months, respectively. The ambulatory blood pressure reduction was significantly lower after 3 and 12 months in SBP and after 12 months in ambulatory DBP, respectively. In conclusion, renal denervation reduces office and ambulatory blood pressure in patients with ISH. However, this reduction is less pronounced compared with patients with CH.