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Sample records for plains cart site

  1. Site Scientific Mission Plan for the Southern Great Plains CART site, July--December 1994

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, J.M.; Lamb, P.J. [Oklahoma Univ., Norman, OK (United States). Cooperative Inst. for Mesoscale Meteorological Studies; Sisterson, D.L. [Argonne National Lab., IL (United States)

    1994-07-01

    The Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) site is designed to help satisfy the data needs of the Atmospheric Radiation Measurement (ARM) Program Science Team. This document defines the scientific priorities for site activities during the six months beginning on July 1, 1994, and also looks forward in lesser detail to subsequent six-month periods. The primary purpose of this Site Scientific Mission Plan is to provide guidance for the development of plans for site operations. It also provides information on current plans to the ARM Functional Teams (Management Team, Experiment Support Team, Operations Team, Data Management Team, Instrument Team, and Campaign Team), and it serves to disseminate the plans more generally within the ARM Program and among the Science Team. This document includes a description of the site`s operational status and the primary envisaged site activities, together with information concerning approved and proposed Intensive Observation Periods. Amendments will be prepared and distributed whenever the content changes by more than 30% within a six-month period. The primary users of this document are the site operator, the site scientist, the Science Team through the ARM Program Science Director, the ARM Program Experiment Center, and the aforementioned ARM Program Functional Teams. This plan is a living document that will be updated and reissued every six months as the observational facilities are developed, tested, and augmented and as priorities are adjusted in response to developments in scientific planning and understanding.

  2. Site scientific mission plan for the Southern Great Plains CART site: July--December 1998

    Energy Technology Data Exchange (ETDEWEB)

    Peppler, R.A.; Lamb, P. [Univ. of Oklahoma, Norman, OK (United States). Cooperative Inst. for Mesoscale Meteorological Studies; Sisterson, D.L. [Argonne National Lab., IL (United States). Environmental Research Div.

    1998-07-01

    The Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) site was designed to help satisfy the data needs of the Atmospheric Radiation Measurement (ARM) Program Science Team. This Site Scientific Mission Plan defines the scientific priorities for site activities during the six months beginning on July 1, 1998, and looks forward in lesser detail to subsequent six-month periods. The primary purpose of this document is to provide scientific guidance for the development of plans for site operations. It also provides information on current plans to the ARM functional teams (Management Team, Data and Science Integration Team [DSIT], Operations Team, and Instrument Team [IT]) and serves to disseminate the plans more generally within the ARM Program and among the members of the Science Team. This document includes a description of the operational status of the site and the primary site activities envisioned, together with information concerning approved and proposed intensive observation periods (IOPs). The primary users of this document are the site operator, the site program manager, the Site Scientist Team (SST), the Science Team through the ARM Program science director, the ARM program Experiment Center, and the aforementioned ARM Program functional teams. This plan is a living document that is updated and reissued every six months as the observational facilities are developed, tested, and augmented and as priorities are adjusted in response to developments in scientific planning and understanding.

  3. Site scientific mission plan for the Southern Great Plains CART Site, January--June 1999

    Energy Technology Data Exchange (ETDEWEB)

    Peppler, R.A.; Sisterson, D.L.; Lamb, P.

    1999-03-10

    The Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) site was designed to help satisfy the data needs of the Atmospheric Radiation Measurement (ARM) Program Science Team. This Site Scientific Mission Plan defines the scientific priorities for site activities during the six months beginning on January 1, 1999, and looks forward in lesser detail to subsequent six-month periods. The primary purpose of this document is to provide scientific guidance for the development of plans for site operations. It also provides information on current plans to the ARM functional teams (Management Team, Data and Science Integration Team [DSIT], Operations Team, and Instrument Team [IT]) and serves to disseminate the plans more generally within the ARM Program and among the members of the Science Team. This document includes a description of the operational status of the site and the primary site activities envisioned, together with information concerning approved and proposed intensive observation periods (IOPs). The primary users of this document are the site operator, the site program manager, the Site Scientist Team (SST), the Science Team through the ARM Program science director, the ARM Program Experiment Center, and the aforementioned ARM Program functional teams. This plan is a living document that is updated and reissued every six months as the observational facilities are developed, tested, and augmented and as priorities are adjusted in response to developments in scientific planning and understanding.

  4. Site scientific mission plan for the Southern Great Plains CART site January--June 1996

    Energy Technology Data Exchange (ETDEWEB)

    Peppler, R.A.; Lamb, P.J. [Univ. of Oklahoma, Norman, OK (United States). Cooperative Inst. for Mesoscale Meteorological Studies; Sisterson, D.L. [Argonne National Lab., IL (United States). Environmental Research Div.

    1996-01-01

    The Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) site is designed to help satisfy the data needs of the Atmospheric Radiation Measurement (ARM) Program Science Team. This document defines the scientific priorities for site activities during the six months beginning on January 1, 1996, and looks forward in lesser detail to subsequent six-month periods. The primary purpose of this Site Scientific Mission Plan is to provide guidance for the development of plans for site operations. It also provides information on current plans to the ARM functional teams (Management Team, Data and Science Integration Team [DSIT], Operations Team, instrument Team [IT], and Campaign Team) and serves to disseminate the plans more generally within the ARM Program and among the members of the Science Team. This document includes a description of the operational status of the site and the primary site activities envisioned, together with information concerning approved and proposed Intensive Observation Periods (IOPs). The primary users of this document are the site operator, the Site Scientist Team (SST), the Science Team through the ARM Program science director, the ARM Program Experiment Center, and the aforementioned ARM program functional teams. This plan is a living document that is updated and reissued every six months as the observational facilities are developed, tested, and augmented and as priorities are adjusted in response to developments in scientific planning and understanding.

  5. Site scientific mission plan for the Southern Great Plains CART site: January 1997--June 1997

    Energy Technology Data Exchange (ETDEWEB)

    Peppler, R.A.; Lamb, P.J. [Univ. of Oklahoma, Norman, OK (United States). Cooperative Institute for Mesoscale Meteorological Studies; Sisterson, D.L. [Argonne National Lab., IL (United States)

    1997-01-01

    The Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) site is designed to help satisfy the data needs of the Atmospheric Radiation Measurement (ARM) Program Science Team. This document defines the scientific priorities for site activities during the six months beginning on January 1, 1997, and looks forward in lesser detail to subsequent six-month periods. The primary purpose of this Site Scientific Mission Plan is to provide guidance for the development of plans for site operations. It also provides information on current plans to the ARM functional teams (Management Team, Data and Science Integration Team [DSIT], Operations Team, Instrument Team [IT], and Campaign Team) and serves to disseminate the plans more generally within the ARM Program and among the members of the Science Team. This document includes a description of the operational status of the site and the primary site activities envisioned, together with information concerning approved and proposed intensive observation periods (IOPs). The primary users of this document are the site operator, the Site Scientist Team (SST), the Science Team through the ARM Program science director, the ARM Program Experiment Center, and the aforementioned ARM Program functional teams. This plan is a living document that is updated and reissued every six months as the observational facilities are developed, tested, and augmented and as priorities are adjusted in response to developments in scientific planning and understanding.

  6. Site scientific mission plan for the Southern Great Plains CART site, January-June 1995

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, J.M.; Lamb, P.J. [Univ. of Oklahoma, Norman, OK (United States); Sisterson, D.L. [Argonne National Lab., IL (United States)

    1994-12-01

    The Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) site is designed to help satisfy the data needs of the Atmospheric Measurement (ARM) Program Science Team. This document defines the scientific priorities for site activities during the six months beginning on January 1, 1995, and also looks forward in lesser detail to subsequent six-month periods. The primary purpose of this Site Scientific Mission Plan is to provide guidance for the development of plans for site operations. It also provides information on current plans to the ARM functional teams (Management Team, Experiment Support Team [EST], Operations Team, Data Management Team [DMT], Instrument Team [IT], and Campaign Team) and serves to disseminate the plans more generally within the ARM Program and among the members of the Science Team. This document includes a description of the operational status of the site and the primary envisaged site activities, together with information concerning approved and proposed Intensive Observation Periods (IOPs). Amendments will be prepared and distributed whenever the content changes by more than 30% within a six-month period. The primary users of this document are the site operator, the site scientist, the Science Team through the ARM Program Science Director, The ARM Program Experiment Center, and the aforementioned ARM Program functional teams. This plan is a living document that will be updated and reissued every six months as the observational facilities are developed, tested, and augmented and as priorities are adjusted in response to developments in scientific planning and understanding.

  7. Site scientific mission plan for the southern Great Plain CART site July-December 1997.

    Energy Technology Data Exchange (ETDEWEB)

    Lamb, P.J.; Peppler, R.A.; Sisterson, D.L.

    1997-08-28

    The Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) site is designed to help satisfy the data needs of the Atmospheric Radiation Measurement (ARM) Program Science Team. This document defines the scientific priorities for site activities during the six months beginning on July 1, 1997, and looks forward in lesser detail to subsequent six-month periods. The primary purpose of this Site Scientific Mission Plan is to provide guidance for the development of plans for site operations. It also provides information on current plans to the ARM functional teams (Management Team, Data and Science Integration Team [DSIT], Operations Team, Instrument Team [IT], and Campaign Team) and serves to disseminate the plans more generally within the ARM Program and among the members of the Science Team. This document includes a description of the operational status of the site and the primary site activities envisioned, together with information concerning approved and proposed intensive observation periods (IOPs). The primary users of this document are the site operator, the Site Scientist Team (SST), the Science Team through the ARM Program science director, the ARM Program Experiment Center, and the aforementioned ARM Program functional teams. This plan is a living document that is updated and reissued every six months as the observational facilities are developed, tested, and augmented and as priorities are adjusted in response to developments in scientific planning and understanding.

  8. Site scientific mission plan for the southern Great Plains CART site, January--June 1998

    Energy Technology Data Exchange (ETDEWEB)

    Peppler, R.A.; Lamb, P.J. [Univ. of Oklahoma, Norman, OK (United States). Cooperative Inst. for Mesoscale Meteorological Studies; Sisterson, D.L. [Argonne National Lab., IL (United States). Environmental Research Div.

    1998-01-01

    The Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) site is designed to help satisfy the data needs of the Atmospheric Radiation Measurement (ARM) Program Science Team. The primary purpose of this site scientific mission plan is to provide guidance for the development of plans for site operations. It also provides information on current plans to the ARM functional teams (Management Team, Data and Science Integration Team, Operations Team, and Instrument Team) and serves to disseminate the plans more generally within the ARM Program and among the members of the Science Team. This document includes a description of the operational status of the site and the primary site activities envisioned, together with information concerning approved and proposed intensive observation periods (IOPs). The primary users of this document are the Site operator, the Site Scientist Team (SST), the Science Team through the ARM Program science director, the ARM Program Experiment Center, and the aforementioned ARM Program functional teams. This plan is a living document that is updated and reissued every six months as the observational facilities are developed, tested, and augmented and as priorities are adjusted in response to developments in scientific planning and understanding.

  9. Site scientific mission plan for the Southern Great Plains CART site: July--December 1996

    Energy Technology Data Exchange (ETDEWEB)

    Peppler, R.A.; Lamb, P.J. [Univ. of Oklahoma, Norman, OK (United States). Cooperative Inst. for Mesoscale Meteorological Studies; Sisterson, D.L. [Argonne National Lab., IL (United States). Environmental Research Div.

    1996-07-01

    The Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) site is designed to help satisfy the data needs of the Atmospheric Radiation Measurement (ARM) Program Science Team. This document defines the scientific priorities for site activities during the six months beginning on July 1, 1996, and looks forward in lesser detail to subsequent six-month periods. The primary purpose of this Site Scientific Mission Plan is to provide guidance for the development of plans for site operations. It also provides information on current plans to the ARM functional teams (Management Team, Data and Science Integration Team [DSIT], Operations Team, Instrument Team [IT], and Campaign Team) and serves to disseminate the plans more generally within the ARM Program and among the members of the Science Team. This document includes a description of the operational status of the site and the primary site activities envisioned, together with information concerning approved and proposed intensive observation periods (IOPs). This plan is a living document that is updated and reissued every six months as the observational facilities are developed, tested, and augmented and as priorities are adjusted in response to developments in scientific planning and understanding. The primary objectives of the ARM program are: to describe the radiative energy flux profile of the clear and cloudy atmosphere; to understand the processes determining the flux profile; and to parameterize the processes determining the flux profile for incorporation into general circulation models.

  10. Site scientific mission plan for the southern great plains CART site, July--December 1995

    Energy Technology Data Exchange (ETDEWEB)

    Splitt, M.E.; Lamb, P.J. [Oklahoma Univ., Norman, OK (United States). Cooperative Inst. for Mesoscale Meteorological Studies; Sisterson, D.L. [Argonne National Lab., IL (United States)

    1995-07-01

    The Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) site is designed to help satisfy the data needs Of the Atmospheric Radiation Measurement (ARM) Program Science Team. This document defines the scientific Priorities for site activities during the six months beginning on July 1, 1995, and looks forward in lesser detail to subsequent six-month periods. The Primary Purpose of this Site Scientific Mission Plan is to provide guidance for the development of plans for site operations. It also provides information on current plans to the ARM functional teams and serves to disseminate the plans more generally within the ARM Program and among the members of the Science Team. This document includes a description of the operational status of the site and the primary envisioned site activities, together with information concerning approved and proposed Intensive Observation Periods (IOPs). This plan is a living document that will be updated and reissued every six months as the observational facilities are developed, tested, and augmented and as Priorities are adjusted in response to developments in scientific planning and understanding.

  11. Site scientific mission plan for the Southern Great Plains CART site: July--December 1997

    Energy Technology Data Exchange (ETDEWEB)

    Peppler, R.A.; Lamb, P.J. [Univ. of Oklahoma, Norman, OK (United States). Cooperative Inst. for Mesoscale Meteorological Studies; Sisterson, D.L. [Argonne National Lab., IL (United States). Environmental Research Div.

    1997-07-01

    The Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) site is designed to help satisfy the data needs of the Atmospheric Radiation Measurement (ARM) Program Science Team. This document defines the scientific priorities for site activities during the six months beginning on July 1, 1997, and looks forward in lesser detail to subsequent six-month periods. The primary purpose of this Site Scientific Mission Plan is to provide guidance for the development of plans for site operations. It also provides information on current plans to the ARM functional teams and serves to disseminate the plans more generally within the ARM Program and among the members of the Science Team. This document includes a description of the operational status of the site and the primary site activities envisioned, together with information concerning approved and proposed intensive observation periods (IOPs). This plan is a living document that is updated and reissued every six months as the observational facilities are developed, tested, and augmented and as priorities are adjusted in response to developments in scientific planning and understanding.

  12. Environmental assessment for the Atmospheric Radiation Measurement (ARM) Program: Southern Great Plains Cloud and Radiation Testbed (CART) site

    Energy Technology Data Exchange (ETDEWEB)

    Policastro, A.J.; Pfingston, J.M.; Maloney, D.M.; Wasmer, F.; Pentecost, E.D.

    1992-03-01

    The Atmospheric Radiation Measurement (ARM) Program is aimed at supplying improved predictive capability of climate change, particularly the prediction of cloud-climate feedback. The objective will be achieved by measuring the atmospheric radiation and physical and meteorological quantities that control solar radiation in the earth`s atmosphere and using this information to test global climate and related models. The proposed action is to construct and operate a Cloud and Radiation Testbed (CART) research site in the southern Great Plains as part of the Department of Energy`s Atmospheric Radiation Measurement Program whose objective is to develop an improved predictive capability of global climate change. The purpose of this CART research site in southern Kansas and northern Oklahoma would be to collect meteorological and other scientific information to better characterize the processes controlling radiation transfer on a global scale. Impacts which could result from this facility are described.

  13. Parameterizing atmosphere-land surface exchange for climate models with satellite data: A case study for the Southern Great Plains CART site

    Science.gov (United States)

    Gao, W.

    High-resolution satellite data provide detailed, quantitative descriptions of land surface characteristics over large areas so that objective scale linkage becomes feasible. With the aid of satellite data, researchers examined the linearity of processes scaled up from 30 m to 15 km. If the phenomenon is scale invariant, then the aggregated value of a function or flux is equivalent to the function computed from aggregated values of controlling variables. The linear relation may be realistic for limited land areas having no large surface contrasts to cause significant horizontal exchange. However, for areas with sharp surface contrasts, horizontal exchange and different dynamics in the atmospheric boundary may induce nonlinear interactions, such as at interfaces of land-water, forest-farm land, and irrigated crops-desert steppe. The linear approach, however, represents the simplest scenario and is useful for developing an effective scheme for incorporating subgrid land surface processes into large-scale models. Our studies focus on coupling satellite data and ground measurements with a satellite-data-driven land surface model to parameterize surface fluxes for large-scale climate models. In this case study, we used surface spectral reflectance data from satellite remote sensing to characterize spatial and temporal changes in vegetation and associated surface parameters in an area of about 350 x 400 km covering the southern Great Plains (SGP) Cloud and Radiation Testbed (CART) site of the US Department of Energy's Atmospheric Radiation Measurement (ARM) Program.

  14. A comparison of radiometric fluxes influenced by parameterization cirrus clouds with observed fluxes at the Southern Great Plains (SGP) cloud and radiation testbed (CART) site

    Energy Technology Data Exchange (ETDEWEB)

    Mace, G.G.; Ackerman, T.P.; George, A.T. [Penn State Univ., University Park, PA (United States)

    1996-04-01

    The data from the Atmospheric Radiation Measurement (ARM) Program`s Southern Great plains Site (SCP) is a valuable resource. We have developed an operational data processing and analysis methodology that allows us to examine continuously the influence of clouds on the radiation field and to test new and existing cloud and radiation parameterizations.

  15. Aspects of the quality of data from the Southern Great Plains (SGP) cloud and radiation testbed (CART) site broadband radiation sensors

    Energy Technology Data Exchange (ETDEWEB)

    Splitt, M.E. [Univ. of Oklahoma, Norman, OK (United States); Wesely, M.L. [Argonne National Lab., IL (United States)

    1996-04-01

    A systmatic evaluation of the performance of broadband radiometers at the Radiation Testbed (CART) site is needed to estimate the uncertainties of the irradiance observations. Here, net radiation observed with the net radiometer in the enrgy balance Bowen ratio station at the Central facility is compared with the net radiation computed as the sum of component irradiances recorded by nearby pyranameters and pyrgeometers. In addition, data obtained from the central facility pyranometers, pyrgeometers, and pyrheliometers are examined for April 1994, when intensive operations periods were being carried out. The data used in this study are from central facility radiometers in a solar and infrared observation station, and EBBR station, the so-called `BSRN` set of upward pointing radiometers, and a set of radiometers pointed down at the 25-m level of a 60-m tower.

  16. A boundary-layer cloud study using Southern Great Plains Cloud and radiation testbed (CART) data

    Energy Technology Data Exchange (ETDEWEB)

    Albrecht, B.; Mace, G.; Dong, X.; Syrett, W. [Pennsylvania State Univ., University Park, PA (United States)] [and others

    1996-04-01

    Boundary layer clouds-stratus and fairweather cumulus - are closely coupled involves the radiative impact of the clouds on the surface energy budget and the strong dependence of cloud formation and maintenance on the turbulent fluxes of heat and moisture in the boundary layer. The continuous data collection at the Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) site provides a unique opportunity to study components of the coupling processes associated with boundary layer clouds and to provide descriptions of cloud and boundary layer structure that can be used to test parameterizations used in climate models. But before the CART data can be used for process studies and parameterization testing, it is necessary to evaluate and validate data and to develop techniques for effectively combining the data to provide meaningful descriptions of cloud and boundary layer characteristics. In this study we use measurements made during an intensive observing period we consider a case where low-level stratus were observed at the site for about 18 hours. This case is being used to examine the temporal evolution of cloud base, cloud top, cloud liquid water content, surface radiative fluxes, and boundary layer structure. A method for inferring cloud microphysics from these parameters is currently being evaluated.

  17. CART (cocaine- and amphetamine-regulated transcript) peptide specific binding sites in PC12 cells have characteristics of CART peptide receptors.

    Science.gov (United States)

    Nagelová, Veronika; Pirník, Zdeno; Železná, Blanka; Maletínská, Lenka

    2014-02-14

    CART (cocaine- and amphetamine-regulated transcript) peptide is a neuropeptide with a powerful central anorexigenic effect. Specific CART peptide binding sites, most likely CART peptide receptors, have been found in PC12 cells. This study further characterizes the CART peptide binding sites in PC12 cells. After differentiation to a neuronal phenotype with nerve growth factor, the number of CART peptide binding sites in PC12 cells tripled. Following dexamethasone treatment, which transforms PC12 cells into chromaffin-like cells, the number of CART peptide binding sites substantially decreased. CART peptide did not affect the differentiation or acetylcholinesterase activity of PC12 cells, indicating that CART peptide does not participate in differentiation or neuronal activity. CART peptide increased the phosphorylation of SAPK/JNK (stress-activated protein kinase/c-Jun-amino-terminal kinase) and subsequent c-Jun protein expression. These effects were reversed by SP600125, a specific JNK-kinase inhibitor. CART peptide did not significantly affect ERK (extracellular signal-regulated kinase), CREB (cAMP responsive element binding protein), or p38 phosphorylation and c-Fos protein expression. Central administration of CART peptide into mice also resulted in increased c-Jun positive cells in dorsomedial hypothalamic nucleus and nucleus of the solitary tract, areas involved in food intake regulation. Activation of c-Jun by CART peptide might indicate a possible role of CART peptide in managing stress conditions rather than a role in cell proliferation or differentiation as well as the more complex and/or specific regulation ways by transcription factors in some nuclei involved in food intake regulation. The characteristics of stress that CART peptide potentially mediates should be further studied.

  18. Implementation of Raman lidar for profiling of atmospheric water vapor and aerosols at the SGP CART site

    Science.gov (United States)

    Goldsmith, J. E. M.; Blair, Forest H.; Bisson, Scott E.

    There are clearly identified scientific requirements for continuous profiling of atmospheric water vapor at the SGP CART (southern great plains cloud and radiation testbed) site. Research conducted at several laboratories, including our work in a previous ARM instrument development project, has demonstrated the suitability of Raman lidar for providing measurements that are an excellent match to those requirements. We are in the final stages of building a ruggedized Raman lidar system that will reside permanently at the CART site, and that is computer automated to reduce the requirements for operator interaction. In addition to the design goal of profiling water vapor through most of the troposphere during nighttime and through the boundary layer during daytime, the lidar will provide quantitative characterization of aerosols and clouds, including depolarization measurements for particle phase studies.

  19. Southern Great Plains Atmospheric Radiation Measurement Site

    Data.gov (United States)

    Federal Laboratory Consortium — The Southern Great Plains Atmospheric Radiation Measurement Site (SGP-ARM) is the oldest and largest of DOE's Arm sites. It was established in 1992. It consists of...

  20. Negligible Details? On a Study of Terracotta Miniature Carts from a Harappan site in Gujarat

    Directory of Open Access Journals (Sweden)

    Elke Rogersdotter

    2006-12-01

    Full Text Available This paper deals with results obtained from an analysed assemblage of Harappan toy- or model carts. It aims to put forward the particular value of studying a limited number of objects while concentrating on details. It further prefers to approach the items not primarily as representations of full-sized carts, but as that what they are; that is, miniature carts.

  1. Atmospheric Profile Retrieval with AIRS Data and Validation at the ARM CART Site

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    The physical retrieval algorithm of atmospheric temperature and moisture distribution from the Atmospheric InfraRed Sounder (AIRS) radiances is presented. The retrieval algorithm is applied to AIRS clear-sky radiance measurements. The algorithm employs a statistical retrieval followed by a subsequent nonlinear physical retrieval. The regression coefficients for the statistical retrieval are derived from a dataset of global radiosonde observations (RAOBs) comprising atmospheric temperature, moisture, and ozone profiles. Evaluation of the retrieved profiles is performed by a comparison with RAOBs from the Atmospheric Radiation Measurement (ARM) Program Cloud And Radiation Testbed (CART) in Oklahoma,U. S. A.. Comparisons show that the physically-based AIRS retrievals agree with the RAOBs from the ARM CART site with a Root Mean Square Error (RMSE) of 1 K on average for temperature profiles above 850 hPa, and approximately 10% on average for relative humidity profiles. With its improved spectral resolution, AIRS depicts more detailed structure than the current Geostationary Operational Environmental Satellite (GOES) sounder when comparing AIRS sounding retrievals with the operational GOES sounding products.

  2. A Nocturnal Boundary Layer Simulation over the ARM-CART Site

    Science.gov (United States)

    Werth, D.; Leclerc, M.; Duarte, H.; Fischer, M.; Kurzeja, R.; Parker, M.

    2008-12-01

    The nocturnal boundary layer (NBL) is characterized by strong inversions and weak turbulent motions. It is during this time that low-level jets (LLJs) often form as the winds aloft reach speeds approaching 15-25m/s at levels below 1000m. During the daytime, turbulent mixing quickly damps such organized motion, but at night the surface cooling establishes an inversion which reduces turbulence and allows jets to form uninhibited. A field project over the ARM-CART site during a period of several nights in September, 2007 was conducted to explore the jet evolution. Data was collected from a tower and analyzed for turbulent behavior. With data limited to a single location, however, the full range of NBL behavior is difficult to determine. The Regional Atmospheric Modeling System (RAMS) is therefore used to simulate the ARM-CART NBL field experiment and validated against the data collected from the site. This model was run at high resolution, and is ideal for calculating the interactions among the various motions within the boundary layer and their influence on the surface. The model can provide information throughout the NBL - with a larger domain, a simulation of the NBL can provide information over a large range of locations and heights. In particular, we are interested in the way that the simulated NBL eddies are affected by their height and proximity to the LLJ, and how this compares to the tower results. The eddy sizes that exist in the model are limited by its grid spacing, but a series of smaller, finer nests allow us to study eddy motion at the relevant scales for short periods.

  3. Emergency-Evacuation Cart

    Science.gov (United States)

    Fedor, Otto H.; Owens, Lester J.

    1988-01-01

    Proposed cart designed to remove injured worker from vicinity of hazardous chemical spill. Self-propelled cart enables rescuer to move victim of industrial accident quickly away from toxic, flammable, explosive, corrosive, carcinogenic, asphyxiating, or extremely cold liquids. Intended for use where too dangerous for ambulances and other vehicles to approach accident site. Constructed of high-strength tubing, rides on bicycle wheels with balloon tires. Rescuer steers cart with handle at rear. Estimated mass of fully equipped vehicle is 650 lb.

  4. Whooping crane stopover site use intensity within the Great Plains

    Science.gov (United States)

    Pearse, Aaron T.; Brandt, David A.; Harrell, Wade C.; Metzger, Kristine L.; Baasch, David M.; Hefley, Trevor J.

    2015-09-23

    Whooping cranes (Grus americana) of the Aransas-Wood Buffalo population migrate twice each year through the Great Plains in North America. Recovery activities for this endangered species include providing adequate places to stop and rest during migration, which are generally referred to as stopover sites. To assist in recovery efforts, initial estimates of stopover site use intensity are presented, which provide opportunity to identify areas across the migration range used more intensively by whooping cranes. We used location data acquired from 58 unique individuals fitted with platform transmitting terminals that collected global position system locations. Radio-tagged birds provided 2,158 stopover sites over 10 migrations and 5 years (2010–14). Using a grid-based approach, we identified 1,095 20-square-kilometer grid cells that contained stopover sites. We categorized occupied grid cells based on density of stopover sites and the amount of time cranes spent in the area. This assessment resulted in four categories of stopover site use: unoccupied, low intensity, core intensity, and extended-use core intensity. Although provisional, this evaluation of stopover site use intensity offers the U.S. Fish and Wildlife Service and partners a tool to identify landscapes that may be of greater conservation significance to migrating whooping cranes. Initially, the tool will be used by the U.S. Fish and Wildlife Service and other interested parties in evaluating the Great Plains Wind Energy Habitat Conservation Plan.

  5. Cable-Dispensing Cart

    Science.gov (United States)

    Bredberg, Alan S.

    2003-01-01

    A versatile cable-dispensing cart can support as many as a few dozen reels of cable, wire, and/or rope. The cart can be adjusted to accommodate reels of various diameters and widths, and can be expanded, contracted, or otherwise reconfigured by use of easily installable and removable parts that can be carried onboard. Among these parts are dispensing rods and a cable guide that enables dispensing of cables without affecting the direction of pull. Individual reels can be mounted on or removed from the cart without affecting the other reels: this feature facilitates the replacement or reuse of partially depleted reels, thereby helping to reduce waste. Multiple cables, wires, or ropes can be dispensed simultaneously. For maneuverability, the cart is mounted on three wheels. Once it has been positioned, the cart is supported by rubber mounts for stability and for prevention of sliding or rolling during dispensing operations. The stability and safety of the cart are enhanced by a low-center-of-gravity design. The cart can readily be disassembled into smaller units for storage or shipping, then reassembled in the desired configuration at a job site.

  6. Analytical study of the effects of the Low-Level Jet on moisture convergence and vertical motion fields at the Southern Great Plains Cloud and Radiation Testbed site

    Energy Technology Data Exchange (ETDEWEB)

    Bian, X.; Zhong, S.; Whiteman, C.D.; Stage, S.A. [Pacific Northwest National Lab., Richland, WA (United States)

    1996-04-01

    The Atmospheric Radiation Measurement (ARM) Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) is located in a region that is strongly affected by a prominent meteorological phenomenon--the Great Plains Low-Level Jet (LLJ). Observations have shown that the LLJ plays a vital role in spring and summertime cloud formation and precipitation over the Great Plains. An improved understanding of the LLJ characteristics and its impact on the environment is necessary for addressing the fundamental issue of development and testing of radiational transfer and cloud parameterization schemes for the general circulation models (GCMs) using data from the SGP CART site. A climatological analysis of the summertime LLJ over the SGP has been carried out using hourly observations from the National Oceanic and Atmospheric Administration (NOAA) Wind Profiler Demonstration Network and from the ARM June 1993 Intensive Observation Period (IOP). The hourly data provide an enhanced temporal and spatial resolution relative to earlier studies which used 6- and 12-hourly rawinsonde observations at fewer stations.

  7. Whooping crane stopover site use intensity within the Great Plains

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Whooping cranes (Grus americana) of the Aransas- Wood Buffalo population migrate twice each year through the Great Plains in North America. Recovery activities for...

  8. [Bullock cart

    OpenAIRE

    Smithson, John Snowden, fl 1903

    2003-01-01

    Showing two bullocks pulling a covered cart along a street lined with stone buildings. Two boys can be seen watching in the foreground and a man is walking between the animals. Another man is walking on the far side of the road.

  9. Groundwater recharge at five representative sites in the Hebei Plain, China.

    Science.gov (United States)

    Lu, Xiaohui; Jin, Menggui; van Genuchten, Martinus Th; Wang, Bingguo

    2011-01-01

    Accurate estimates of groundwater recharge are essential for effective management of groundwater, especially when supplies are limited such as in many arid and semiarid areas. In the Hebei Plain, China, water shortage is increasingly restricting socioeconomic development, especially for agriculture, which heavily relies on groundwater. Human activities have greatly changed groundwater recharge there during the past several decades. To obtain better estimates of recharge in the plain, five representative sites were selected to investigate the effects of irrigation and water table depth on groundwater recharge. At each site, a one-dimensional unsaturated flow model (Hydrus-1D) was calibrated using field data of climate, soil moisture, and groundwater levels. A sensitivity analysis of evapotranspirative fluxes and various soil hydraulic parameters confirmed that fine-textured surface soils generally generate less recharge. Model calculations showed that recharge on average is about 175 mm/year in the piedmont plain to the west, and 133 mm/year in both the central alluvial and lacustrine plains and the coastal plain to the east. Temporal and spatial variations in the recharge processes were significant in response to rainfall and irrigation. Peak time-lags between infiltration (rainfall plus irrigation) and recharge were 18 to 35 days in the piedmont plain and 3 to 5 days in the central alluvial and lacustrine plains, but only 1 or 2 days in the coastal plain. This implies that different time-lags corresponding to different water table depths must be considered when estimating or modeling groundwater recharge.

  10. Aerosol measurements at the Southern Great Plains Site: Design and surface installation

    Energy Technology Data Exchange (ETDEWEB)

    Leifer, R.; Knuth, R.H.; Guggenheim, S.F.; Albert, B. [Department of Energy, New York, NY (United States)

    1996-04-01

    To impropve the predictive capabilities of the Atmospheric Radiation Measurements (ARM) program radiation models, measurements of awserosol size distributions, condensation particle concentrations, aerosol scattering coefficients at a number of wavelenghts, and the aerosol absorption coefficients are needed at the Southern Great Plains (SGP) site. Alos, continuous measurements of ozone concnetrations are needed for model validation. The environmental Measuremenr Laboratory (EMK) has the responsibility to establish the surface aerosol measurements program at the SGP site. EML has designed a special sampling manifold.

  11. [Two-wheeled cart

    OpenAIRE

    2003-01-01

    205 x 139 mm. A view showing a two-wheeled wooden cart being pulled by two bovine quadrupeds. A man is sitting in the cart and a European man is standing to the side watching. Photograph taken circa 1900.

  12. Sensitivity and specificity of plain radiographic features of peripheral enthesopathy at major sites in psoriatic arthritis

    Energy Technology Data Exchange (ETDEWEB)

    Helliwell, P.S. [University of Leeds, Academic Unit of Musculoskeletal and Rehabilitation Medicine, Leeds (United Kingdom); Porter, G. [Airedale Hospital NHS Trust, Keighley, West Yorkshire (United Kingdom)

    2007-11-15

    It has been proposed that the defining difference between rheumatoid arthritis and spondyloarthropathy (including psoriatic arthritis) is the initial pathological lesion where the emphasis in psoriatic arthritis is on the enthesis and in rheumatoid arthritis on the synovium. Classical radiological descriptions of seronegative spondyloarthropathy include enthesopathy at major entheseal insertions characterised by erosions and exuberant new bone formation. In this study, the plain radiographic features of spondyloarthropathy are compared between psoriatic arthritis, other spondyloarthropathies and rheumatoid arthritis. The CASPAR study collected clinical, radiological and laboratory data on 588 patients with physician diagnosed psoriatic arthritis and 525 controls with other inflammatory arthritis, 70% of which had rheumatoid arthritis. Plain radiographs of the pelvis and heels were part of the study protocol, although radiographs of other potential entheseal sites such as the knee, elbow and shoulder, were interpreted if available. All radiographs were read blind by two observers working in tandem. Significant differences in entheseal erosion and entheseal new bone formation were found between psoriatic arthritis, ankylosing spondylitis, undifferentiated spondyloarthropathy, rheumatoid arthritis and other diagnoses (entheseal erosion, chi-squared 20.8, p = 0.008; entheseal new bone formation, chi-squared 24.5, p = 0.001). These differences were mainly due to a higher proportion of these features in ankylosing spondylitis. No differences in the plain radiographic features of enthesopathy were found between psoriatic arthritis and rheumatoid arthritis except in the case of entheseal new bone formation at sites of attachment of inguinal ligament, sartorius and rectus femoris muscles to the ilium (OR 3.01, 95% CI 1.13-8.02). Very few subjects with symptomatic heel involvement had radiographic changes and minimal differences were found between those with and without

  13. A case study of the Great Plains low-level jet using wind profiler network data and a high resolution mesoscale model

    Energy Technology Data Exchange (ETDEWEB)

    Zhong, S.; Fast, J.D.; Bian, X.; Stage, S. [Pacific Northwest National Lab., Richland, WA (United States)] [and others

    1996-04-01

    The Great Plains low-level jet (LLJ) has important effects on the life cycle of clouds and on radiative and surface heat and moisture fluxes at the Atmospheric Radiation Measurement (ARM) Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) site. This diurnal phenomenon governs the transport and convergence of low-level moisture into the region and often leads to the development of clouds and precipitation. A full understanding of the life cycle of clouds at the SGP CART site and their proper representation in single column and global climate models cannot be obtained without an improved understanding of this important phenomenon.

  14. Service Cart For Engines

    Science.gov (United States)

    Ng, Gim Shek

    1995-01-01

    Cart supports rear-mounted air-cooled engine from Volkswagen or Porsche automobile. One person removes, repairs, tests, and reinstalls engine of car, van, or home-built airplane. Consists of framework of wood, steel, and aluminum components supported by four wheels. Engine lifted from vehicle by hydraulic jack and gently lowered onto waiting cart. Jack removed from under engine. Rear of vehicle raised just enough that engine can be rolled out from under it. Cart easily supports 200-lb engine. Also used to hold transmission. With removable sheet-metal top, cart used as portable seat.

  15. Service Cart For Engines

    Science.gov (United States)

    Ng, Gim Shek

    1995-01-01

    Cart supports rear-mounted air-cooled engine from Volkswagen or Porsche automobile. One person removes, repairs, tests, and reinstalls engine of car, van, or home-built airplane. Consists of framework of wood, steel, and aluminum components supported by four wheels. Engine lifted from vehicle by hydraulic jack and gently lowered onto waiting cart. Jack removed from under engine. Rear of vehicle raised just enough that engine can be rolled out from under it. Cart easily supports 200-lb engine. Also used to hold transmission. With removable sheet-metal top, cart used as portable seat.

  16. Recent Subsidence and Erosion at Diverse Wetland Sites in the Southeastern Mississippi Delta Plain

    Science.gov (United States)

    Morton, Robert A.; Bernier, Julie C.; Kelso, Kyle W.

    2009-01-01

    A prior study (U.S. Geological Survey Open-File Report 2005-1216) examined historical land- and water-area changes and estimated magnitudes of land subsidence and erosion at five wetland sites in the Terrebonne hydrologic basin of the Mississippi delta plain. The present study extends that work by analyzing interior wetland loss and relative magnitudes of subsidence and erosion at five additional wetland sites in the adjacent Barataria hydrologic basin. The Barataria basin sites were selected for their diverse physical settings and their recent (post-1978) conversion from marsh to open water. Historical aerial photography, datum-corrected marsh elevations and water depths, sediment cores, and radiocarbon dates were integrated to evaluate land-water changes in the Mississippi delta plain on both historical and geological time scales. The thickness of the organic-rich sediments (peat) and the elevation of the stratigraphic contact between peat and underlying mud were compared at marsh and open-water sites across areas of formerly continuous marsh to estimate magnitudes of recent delta-plain elevation loss caused by vertical erosion and subsidence of the wetlands. Results of these analyses indicate that erosion exceeded subsidence at most of the study areas, although both processes have contributed to historical wetland loss. Comparison of these results with prior studies indicates that subsidence largely caused rapid interior wetland loss in the Terrebonne basin before 1978, whereas erosional processes primarily caused more gradual interior wetland loss in the Barataria basin after 1978. Decadal variations in rates of relative sea-level rise at a National Ocean Service tide gage, elevation changes between repeat benchmark-leveling surveys, and GPS height monitoring at three National Geodetic Survey Continuously Operating Reference Stations indicate that subsidence rates since the early 1990s are substantially lower than those previously reported and are similar in

  17. Siting MSW landfills using MCE methodology in GIS environment (Case study: Birjand plain, Iran).

    Science.gov (United States)

    Motlagh, Zeynab Karimzadeh; Sayadi, Mohammad Hossein

    2015-12-01

    The rapid municipal solid waste growth of Birjand plain causes to find an appropriate site selection for the landfill. In order to reduce the negative impacts of waste, the use of novel tools and technologies to gain a suitable site for landfill seems imperative. The present paper aimed to exhibits the Multi Criteria Evaluation (MCE) for the landfill site selection of the Birjand plain because till date a suitable action has not been implicated. In the present research, the parameters such as environmental and socio-economical factors have been used. The factors like slope, water resources, soil parameters, landuse, fault and protected areas in the model of effective environmental criteria and the factors viz. distance from road, urban areas, village, airport, historical place, and industries in the model of socio-economic criteria were investigated and with the use of Weighted Linear Combination (WLC) and Analytical Network Process (ANP) models were compounded and according to the Ordered Weighted Averaging (OWA) and Fuzzy Linguistic Quantifier (LQ) were aggregated. The paper focuses on the OWA method as well as an approach for integrating Geographic Information System (GIS) and OWA. OWA has been developed as a generalization of multi-criteria combination. In this study we attained comparable data via the technique of ANP and five scenarios of OWA method were used. The results of field studies, fifth scenario for the study area proposed. Based on the research findings, OWA method had a great potential and flexibility in the modeling of the complex decision-making problems.

  18. Design of the aerosol sampling manifold for the Southern Great Plains site

    Energy Technology Data Exchange (ETDEWEB)

    Leifer, R.; Knuth, R.H.; Guggenheim, S.F.; Lee, H.N. [Dept. of Energy, New York, NY (United States)

    1995-04-01

    To meet the needs of the ARM program, the Environmental Measurements Laboratory (EML) has the responsibility to establish a surface aerosol measurements program at the Southern Great Plains (SGP) site in Lamont, OK. At the present time, EML has scheduled installation of five instruments at SGP: a single wavelength nephelometer, an optical particle counter (OPC), a condensation particle counter (CPC), an optical absorption monitor (OAM), and an ozone monitor. ARM`s operating protocol requires that all the observational data be placed online and sent to the main computer facility in real time. EML currently maintains a computer file containing back trajectory (BT) analyses for the SGP site. These trajectories are used to characterize air mass types as they pass over the site. EML is continuing to calculate and store the resulting trajectory analyses for future use by the ARM science team.

  19. Bed site selection by neonate deer in grassland habitats on the northern Great Plains

    Science.gov (United States)

    Grovenburg, T.W.; Jacques, C.N.; Klaver, R.W.; Jenks, J.A.

    2010-01-01

    Bed site selection is an important behavioral trait influencing neonate survival. Vegetation characteristics of bed sites influence thermal protection of neonates and concealment from predators. Although previous studies describe bed site selection of neonatal white-tailed deer (Odocoileus virginianus) in regions of forested cover, none determined microhabitat effects on neonate bed site selection in the Northern Great Plains, an area of limited forest cover. During summers 2007–2009, we investigated bed site selection (n  =  152) by 81 radiocollared neonate white-tailed deer in north-central South Dakota, USA. We documented 80 (52.6%) bed sites in tallgrass–Conservation Reserve Program lands, 35 (23.0%) bed sites in forested cover, and 37 (24.3%) in other habitats (e.g., pasture, alfalfa, wheat). Bed site selection varied with age and sex of neonate. Tree canopy cover (P ratio  =  1.035, 95% CI  =  1.008–1.062) for every 1-cm increase in vertical height of understory vegetation. Management for habitat throughout the grasslands of South Dakota that maximizes vertical height of understory vegetation would enhance cover characteristics selected by neonates.

  20. Microbiological surface sampling cart

    Science.gov (United States)

    Wilkins, J. R.; Mills, S. M.

    1972-01-01

    Mobile sampling cart automatically swabs surfaces for the recovery of microorganisms. Unit operates without human involvement and provides for control of swabbing speed, rotation of cotton swab, and the pressure and angle applied to swab. Capability of reverse direction is also available. Sampling cart use is limited to flat surfaces.

  1. Characterization of the Two CART Genes (CART1 and CART2) in Chickens (Gallus gallus)

    OpenAIRE

    2015-01-01

    Cocaine- and amphetamine-regulated transcript (CART) peptide is implicated in the control of avian energy balance, however, the structure and expression of CART gene(s) remains largely unknown in birds. Here, we cloned and characterized two CART genes (named cCART1 and cCART2) in chickens. The cloned cCART1 is predicted to generate two bioactive peptides, cCART1(42-89) and cCART1(49-89), which share high amino acid sequence identity (94-98%) with their mammalian counterparts, while the novel ...

  2. Mercury Shopping Cart Interface

    Science.gov (United States)

    Pfister, Robin; McMahon, Joe

    2006-01-01

    Mercury Shopping Cart Interface (MSCI) is a reusable component of the Power User Interface 5.0 (PUI) program described in another article. MSCI is a means of encapsulating the logic and information needed to describe an orderable item consistent with Mercury Shopping Cart service protocol. Designed to be used with Web-browser software, MSCI generates Hypertext Markup Language (HTML) pages on which ordering information can be entered. MSCI comprises two types of Practical Extraction and Report Language (PERL) modules: template modules and shopping-cart logic modules. Template modules generate HTML pages for entering the required ordering details and enable submission of the order via a Hypertext Transfer Protocol (HTTP) post. Shopping cart modules encapsulate the logic and data needed to describe an individual orderable item to the Mercury Shopping Cart service. These modules evaluate information entered by the user to determine whether it is sufficient for the Shopping Cart service to process the order. Once an order has been passed from MSCI to a deployed Mercury Shopping Cart server, there is no further interaction with the user.

  3. Characterization of the Two CART Genes (CART1 and CART2) in Chickens (Gallus gallus).

    Science.gov (United States)

    Cai, Guoqing; Mo, Chunheng; Huang, Long; Li, Juan; Wang, Yajun

    2015-01-01

    Cocaine- and amphetamine-regulated transcript (CART) peptide is implicated in the control of avian energy balance, however, the structure and expression of CART gene(s) remains largely unknown in birds. Here, we cloned and characterized two CART genes (named cCART1 and cCART2) in chickens. The cloned cCART1 is predicted to generate two bioactive peptides, cCART1(42-89) and cCART1(49-89), which share high amino acid sequence identity (94-98%) with their mammalian counterparts, while the novel cCART2 may produce a bioactive peptide cCART2(51-91) with 59% identity to cCART1. Interestingly, quantitative RT-PCR revealed that cCART1 is predominantly expressed in the anterior pituitary and less abundantly in the hypothalamus. In accordance with this finding, cCART1 peptide was easily detected in the anterior pituitary by Western blot, and its secretion from chick pituitaries incubated in vitro was enhanced by ionomycin and forskolin treatment, indicating that cCART1 is a novel peptide hormone produced by the anterior pituitary. Moreover, cCART1 mRNA expression in both the pituitary and hypothalamus is down-regulated by 48-h fasting, suggesting its expression is affected by energy status. Unlike cCART1, cCART2 is only weakly expressed in most tissues examined by RT-PCR, implying a less significant role of cCART2 in chickens. As in chickens, 2 or more CART genes, likely generated by gene and genome duplication event(s), were also identified in other non-mammalian vertebrate species including coelacanth. Collectively, the identification and characterization of CART genes in birds helps to uncover the roles of CART peptide(s) in vertebrates and provides clues to the evolutionary history of vertebrate CART genes.

  4. Characterization of the Two CART Genes (CART1 and CART2) in Chickens (Gallus gallus)

    Science.gov (United States)

    Huang, Long; Li, Juan; Wang, Yajun

    2015-01-01

    Cocaine- and amphetamine-regulated transcript (CART) peptide is implicated in the control of avian energy balance, however, the structure and expression of CART gene(s) remains largely unknown in birds. Here, we cloned and characterized two CART genes (named cCART1 and cCART2) in chickens. The cloned cCART1 is predicted to generate two bioactive peptides, cCART1(42-89) and cCART1(49-89), which share high amino acid sequence identity (94-98%) with their mammalian counterparts, while the novel cCART2 may produce a bioactive peptide cCART2(51-91) with 59% identity to cCART1. Interestingly, quantitative RT-PCR revealed that cCART1 is predominantly expressed in the anterior pituitary and less abundantly in the hypothalamus. In accordance with this finding, cCART1 peptide was easily detected in the anterior pituitary by Western blot, and its secretion from chick pituitaries incubated in vitro was enhanced by ionomycin and forskolin treatment, indicating that cCART1 is a novel peptide hormone produced by the anterior pituitary. Moreover, cCART1 mRNA expression in both the pituitary and hypothalamus is down-regulated by 48-h fasting, suggesting its expression is affected by energy status. Unlike cCART1, cCART2 is only weakly expressed in most tissues examined by RT-PCR, implying a less significant role of cCART2 in chickens. As in chickens, 2 or more CART genes, likely generated by gene and genome duplication event(s), were also identified in other non-mammalian vertebrate species including coelacanth. Collectively, the identification and characterization of CART genes in birds helps to uncover the roles of CART peptide(s) in vertebrates and provides clues to the evolutionary history of vertebrate CART genes. PMID:25992897

  5. Characterization of the Two CART Genes (CART1 and CART2 in Chickens (Gallus gallus.

    Directory of Open Access Journals (Sweden)

    Guoqing Cai

    Full Text Available Cocaine- and amphetamine-regulated transcript (CART peptide is implicated in the control of avian energy balance, however, the structure and expression of CART gene(s remains largely unknown in birds. Here, we cloned and characterized two CART genes (named cCART1 and cCART2 in chickens. The cloned cCART1 is predicted to generate two bioactive peptides, cCART1(42-89 and cCART1(49-89, which share high amino acid sequence identity (94-98% with their mammalian counterparts, while the novel cCART2 may produce a bioactive peptide cCART2(51-91 with 59% identity to cCART1. Interestingly, quantitative RT-PCR revealed that cCART1 is predominantly expressed in the anterior pituitary and less abundantly in the hypothalamus. In accordance with this finding, cCART1 peptide was easily detected in the anterior pituitary by Western blot, and its secretion from chick pituitaries incubated in vitro was enhanced by ionomycin and forskolin treatment, indicating that cCART1 is a novel peptide hormone produced by the anterior pituitary. Moreover, cCART1 mRNA expression in both the pituitary and hypothalamus is down-regulated by 48-h fasting, suggesting its expression is affected by energy status. Unlike cCART1, cCART2 is only weakly expressed in most tissues examined by RT-PCR, implying a less significant role of cCART2 in chickens. As in chickens, 2 or more CART genes, likely generated by gene and genome duplication event(s, were also identified in other non-mammalian vertebrate species including coelacanth. Collectively, the identification and characterization of CART genes in birds helps to uncover the roles of CART peptide(s in vertebrates and provides clues to the evolutionary history of vertebrate CART genes.

  6. Cartes hors texte

    OpenAIRE

    2013-01-01

    1 – Carte de la Martinique IRD-Bondy-LCA 2 – Carte de situation des Antilles IRD-Bondy-LCA 3 – Carte topo-climatique de la Martinique IRD-Bondy-LCA 4 – Banane et bananeraies en 1969 en Martinique IRD-Bondy-LCA 5 – Banane et bananeraies en 1980 en Martinique IRD-Bondy-LCA 6 – Les sols de Martinique IRD-Bondy-LCA 7 – Canne à sucre en 1969 et 1980 en Martinique IRD-Bondy-LCA

  7. A one-year climatology using data from the Southern Great Plains (SGP) site micropulse lidar

    Energy Technology Data Exchange (ETDEWEB)

    Mace, G.G.; Ackerman, T.P. [Penn State Univ., University Park, PA (United States); Spinhirne, J.; Scott, S. [NASA Goddard Space Flight Center, Greenbelt, MD (United States)

    1996-04-01

    The micropulse lidar (MPL) has been operational at the Southern Great Plains (SGP) site of the Atmospheric Radiation Measurement Program for the past 15 months. The compact MPL is unique among research lidar systems in that it is eye-safe and operates continuously, except during precipitation. The MPL is capable of detecting cloud base throughout the entire depth of the troposphere. The MPL data set is an unprecedented time series of cloud heights. It is a vital resource for understanding the frequency of cloud ocurrence and the impact of clouds on the surface radiation budget, as well as for large-scale model validation and satellite retrieval verification. The raw lidar data are processed for cloud base height at a temporal frequency of one minute and a vertical resolution of 270 m. The resultant time series of cloud base is used to generate histograms as a function of month and time of day. Sample results are described.

  8. Madeira. Bullock cart

    OpenAIRE

    Unknown

    2003-01-01

    229 x 175 mm. Showing two passengers seated in a characteristic Maderia bullock cart or sled, with two drivers standing beside the animals and two other figures seated on the steps in the background. Photograph taken in the 1880s.

  9. Atrazine retention and degradation in the vadose zone at a till plain site in central Indiana

    Science.gov (United States)

    Bayless, E.R.

    2001-01-01

    The vadose zone was examined as an environmental compartment where significant quantities of atrazine and its degradation compounds may be stored and transformed. The vadose zone was targeted because regional studies in the White River Basin indicated a large discrepancy between the mass of atrazine applied to fields and the amount of the pesticide and its degradation compounds that are measured in ground and surface water. A study site was established in a rotationally cropped field in the till plain of central Indiana. Data were gathered during the 1994 growing season to characterize the site hydrogeology and the distribution of atrazine, desethylatrazine, deisopropylatrazine, didealkylatrazine and hydroxyatrazine in runoff, pore water, and ground water. The data indicated that atrazine and its degradation compounds were transported from land surface to a depth of 1.5 m within 60 days of application, but were undetected in the saturated zone at nearby monitoring wells. A numerical model was developed, based on the field data, to provide information about processes that could retain and degrade atrazine in the vadose zone. Simulations indicated that evapotranspiration is responsible for surface directed soil-moisture flow during much of the growing season. This process causes retention and degradation of atrazine in the vadose zone. Increased residence time in the vadose zone leads to nearly complete transformation of atrazine and its degradation products to unquantified degradation compounds. As a result of mascropore flow, small quantities of atrazine and its degradation compounds may reach the saturated zone.

  10. Geochronology and Geomorphology of the Pioneer Archaeological Site (10BT676), Upper Snake River Plain, Idaho

    Energy Technology Data Exchange (ETDEWEB)

    Keene, Joshua L. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-04-01

    The Pioneer site in southeastern Idaho, an open-air, stratified, multi-component archaeological locality on the upper Snake River Plain, provides an ideal situation for understanding the geomorphic history of the Big Lost River drainage system. We conducted a block excavation with the goal of understanding the geochronological context of both cultural and geomorphological components at the site. The results of this study show a sequence of five soil formation episodes forming three terraces beginning prior to 7200 cal yr BP and lasting until the historic period, preserving one cultural component dated to ~3800 cal yr BP and multiple components dating to the last 800 cal yr BP. In addition, periods of deposition and stability at Pioneer indicate climate fluctuation during the middle Holocene (~7200-3800 cal yr BP), minimal deposition during the late Holocene, and a period of increased deposition potentially linked to the Little Ice Age. In addition, evidence for a high-energy erosion event dated to ~3800 cal yr BP suggest a catastrophic flood event during the middle Holocene that may correlate with volcanic activity at the Craters of the Moon lava fields to the northwest. This study provides a model for the study of alluvial terrace formations in arid environments and their potential to preserve stratified archaeological deposits.

  11. Organic and Elemental Carbon Aerosol Particulates at the Southern Great Plains Site Field Campaign Report

    Energy Technology Data Exchange (ETDEWEB)

    Cary, Robert

    2016-04-01

    The purpose of this study was to measure the organic carbon (OC) and elemental carbon (EC) fractions of PM2.5 particulate matter at the U.S. Department of Energy (DOE)’s Atmospheric Radiation Measurement (ARM) Climate Research Facility Southern Great Plains (SGP) sampling site for a 6-month period during the summer of 2013. The site is in a rural location remote from any populated areas, so it would be expected to reflect carbon concentration over long-distance transport patterns. During the same period in 2012, a number of prairie fires in Oklahoma and Texas had produced large plumes of smoke particles, but OC and EC particles had not been quantified. In addition, during the summer months, other wild fires, such as forest fires in the Rocky Mountain states and other areas, can produce carbon aerosols that are transported over long distances. Both of these source types would be expected to contain mixtures of both OC and EC.

  12. Geochemistry of aerosols from an urban site, Varanasi, in the Eastern Indo-Gangetic Plain

    Science.gov (United States)

    Ram, Kirpa; Norra, Stefan; Zirzov, Felix; Singh, Sunita; Mehra, Manisha; Nanad Tripathi, Sachichida

    2016-04-01

    PM2.5 aerosol samples were collected from an urban site, Varanasi, in the eastern Indo-Gangetic Plain on weekly basis during 19 March to 29 May 2015 (n=12), along with daily samples (n=8) during 11 to 18 March 2015 to study the geochemical and morphological features of aerosols. Samples were collected with a low volume sampler (Leckel GmbH, Germany) on the terrace of the Institute of Environment and Sustainable Development building, located in the Banaras Hindu University campus in the southern part of the city. Samples were analyzed for element concentration by Inductively Coupled Plasma Mass Spectrometry and particle morphology by Scanning Electron Microscope. PM2.5 concentration ranged between 22.3 and 70.5 μgm-3 in daily samples, whereas those varied between 52.0 and 106 μgm-3 in weekly samples. Lead, potassium, aluminum, zinc and iron have conspicuously higher concentrations with Pb concentration exceeding above the annual limit of 50 ngm-3 in four samples. First results show a trend of corresponding concentrations of chemical elements originated from anthropogenic and geogenic sources. The biogenic particles are a minor fraction of the total particulate aerosols. The Hybrid Single-Particle Lagrangian Integrated Trajectory (HYSPLIT) back trajectory analysis of air parcels indicate that the air mass for the low loaded days originate from eastern directions including the region of the gulf of Bengal, where as high aerosols concentrations in cases of air masses arriving from north-western direction transporting the air pollutants from the Gangetic Plain towards Varanasi. Black carbon (BC) concentration, measured using an microaethalometer (AE-51), exhibit a strong variability (4.4 to 8.4 μg m-3) in the University campus which are ˜20-40% lower than those measured in the Varanasi city. The carbon content was found to be high with soot particles constituting the largest part in these samples and exist as single particle as well as attachment to other particles

  13. The lunar cart

    Science.gov (United States)

    Miller, G. C.

    1972-01-01

    Expanded experiment-carrying capability, to be used between the Apollo 11 capability and the lunar roving vehicle capability, was defined for the lunar surface crewmen. Methods used on earth to satisfy similar requirements were studied. A two-wheeled cart was built and tested to expected mission requirements and environments. The vehicle was used successfully on Apollo 14.

  14. Jeux de cartes

    Directory of Open Access Journals (Sweden)

    Pierre GENTELLE

    1986-09-01

    Full Text Available Dans la grande tradition de la science-fiction et des lieux imaginaires traduits ici en «jeux» de cartes, l'auteur bouleverse quelques localisations au prix de mouvements tectoniques imprévus et en prévoit quelques conséquences.

  15. Zen Cart, the Online Shopping Cart Platform

    OpenAIRE

    2007-01-01

    Tato bakalářská práce se zabývá open source platformou pro internetový obchod s názvem Zen Cart a konkrétně se zaměřuje na řešení systému objednávek z pohledu uživatele (administrátora). Část práce se věnuje hodnocení objednávek ve standardní instalaci. Dále se věnuje optimalizaci vyhledávání a rozšíření funkcí pro vícejazyčné obchody. V poslední části popisuje navržený a implementovaný plug-in umožňující export objednávek.

  16. Le logiciel FastCart

    OpenAIRE

    1986-01-01

    FastCart est un logiciel destiné à l'enseignement de la géographie. Il permet aux élèves de créer leurs propres documents d'études: histogrammes, cartes en hachures, cartes de classification de l'espace. Sa rapidité d'exécution et sa facilité d'utilisation en font un outil adapté aux exigences des enseignants.

  17. Fan Cart: The Next Generation

    Science.gov (United States)

    Lamore, Brian

    2016-10-01

    For years the fan cart has provided physics students with an excellent resource for exploring fundamental mechanics concepts such as acceleration, Newton's laws, impulse, momentum, work-energy, and energy conversions. The Physics Teacher has even seen some excellent do-it-yourself (DIY) fan carts and activities. If you are interested in developing the `E' portion of your and your students' STEM (science, technology, engineering, and math) skills, one way to accomplish this is to revisit the DIY fan cart. In this article I share a design of a new edition of the DIY fan cart and some ideas for incorporating the engineering design process into your high school curriculum.

  18. Enhanced Geothermal System Potential for Sites on the Eastern Snake River Plain, Idaho

    Energy Technology Data Exchange (ETDEWEB)

    Robert K Podgorney; Thomas R. Wood; Travis L McLing; Gregory Mines; Mitchell A Plummer; Michael McCurry; Ahmad Ghassemi; John Welhan; Joseph Moore; Jerry Fairley; Rachel Wood

    2013-09-01

    The Snake River volcanic province overlies a thermal anomaly that extends deep into the mantle and represents one of the highest heat flow provinces in North America (Blackwell and Richards, 2004). This makes the Snake River Plain (SRP) one of the most under-developed and potentially highest producing geothermal districts in the United States. Elevated heat flow is typically highest along the margins of the topographic SRP and lowest along the axis of the plain, where thermal gradients are suppressed by the Snake River aquifer. Beneath this aquifer, however, thermal gradients rise again and may tap even higher heat flows associated with the intrusion of mafic magmas into the mid-crustal sill complex (e.g., Blackwell, 1989).

  19. Variable selection through CART

    CERN Document Server

    Sauvé, Marie

    2011-01-01

    This paper deals with variable selection in the regression and binary classification frameworks. It proposes an automatic and exhaustive procedure which relies on the use of the CART algorithm and on model selection via penalization. This work, of theoretical nature, aims at determining adequate penalties, i.e. penalties which allow to get oracle type inequalities justifying the performance of the proposed procedure. Since the exhaustive procedure can not be executed when the number of variables is too big, a more practical procedure is also proposed and still theoretically validated. A simulation study completes the theoretical results.

  20. University of Pennsylvania aspiration cart (Penn-A-Cart): an innovative journey in fine needle aspiration service.

    Science.gov (United States)

    Gupta, Prabodh K

    2010-01-01

    On-site evaluation of fine needle aspiration specimens is now considered the standard of care. The procedure is performed at the bedside and at various other locations within the hospital using a mobile cart fitted with essentials, including a microscope, stains and supplies. Earlier, an open specimen cart was used with various supplies and a binocular microscope. The mobile cart during the past 25 years has been variously modified. A second-generation cart containing 2 folding pods, a double-headed microscope, supplies and stains had been used for the past 20 years; it did not meet the current regulatory standards and needs, and little attention was paid to meet the Joint Commission on the Accreditation of Healthcare Organizations, Health Insurance Portability and Accountability Act and infection control standards. Also, the repeated lifting of the microscope resulted in much wear and tear. We have designed Penn-A-Cart, which has a pneumatic lift for the microscope, a high-definition camera with a TV screen and access to the Internet. It has a sharps container and storage space for supplies, stains and slides. This cart meets the various regulatory agency standards. It is user friendly and valuable for multiviewing. The cart is valuable for remote access, telecytopathology and improved patient care.

  1. Modeling the Impact of Biogeochemical Hotspots and Hot Moments on Subsurface Carbon Fluxes from a Flood Plain Site

    Science.gov (United States)

    Arora, B.; Spycher, N.; Steefel, C. I.; King, E.; Conrad, M. E.

    2015-12-01

    Biogeochemical hotspots and hot moments are known to account for a high percentage of carbon and nutrient cycling within flood plain environments. To quantify the impact of these hotspots and hot moments on the carbon cycle, a 2D reactive transport model was developed for the saturated-unsaturated zone of a flood plain site in Rifle, CO. Previous studies have identified naturally reduced zones (NRZs) in the saturated zone of the Rifle site to be hotspots and important regions for subsurface biogeochemical cycling. Wavelet analysis of geochemical concentrations at the site suggested that hydrologic and temperature variations are hot moments and exert an important control on biogeochemical conditions in the Rifle aquifer. Here, we describe the development of a reactive transport model that couples hydrologic and biogeochemical processes to microbial functional distributions inferred from site-specific 'omic' data. The model includes microbial contributions from heterotrophic and chemolithoautotrophic processes. We use Monod based formulations to represent biomass formation and consider energy partitioning between catabolic and anabolic processes. We use this model to explore community emergence at the Rifle site and further constrain the extent and rates of nutrient uptake as well as abiotic and biotic reactions using stable carbon isotopes. Results from 2D model simulations with only abiotic reactions predict lower CO2 partial pressures in the unsaturated zone and severely underpredict (~200%) carbon fluxes to the river compared to simulations with chemolithoautotrophic pathways. δ13C-CO2 profiles also point to biotic sources for the locally observed high CO2 concentrations above NRZs. Results further indicate that groundwater carbon fluxes from the Rifle site to the river are underestimated by almost 180% (to 3.3 g m-2 d-1) when temperature fluctuations are ignored in the simulations. Preliminary results demonstrate the emergence of denitrifiers at specific depths

  2. Controlling errors in unidosis carts

    Directory of Open Access Journals (Sweden)

    Inmaculada Díaz Fernández

    2010-01-01

    Full Text Available Objective: To identify errors in the unidosis system carts. Method: For two months, the Pharmacy Service controlled medication either returned or missing from the unidosis carts both in the pharmacy and in the wards. Results: Uncorrected unidosis carts show a 0.9% of medication errors (264 versus 0.6% (154 which appeared in unidosis carts previously revised. In carts not revised, the error is 70.83% and mainly caused when setting up unidosis carts. The rest are due to a lack of stock or unavailability (21.6%, errors in the transcription of medical orders (6.81% or that the boxes had not been emptied previously (0.76%. The errors found in the units correspond to errors in the transcription of the treatment (3.46%, non-receipt of the unidosis copy (23.14%, the patient did not take the medication (14.36%or was discharged without medication (12.77%, was not provided by nurses (14.09%, was withdrawn from the stocks of the unit (14.62%, and errors of the pharmacy service (17.56% . Conclusions: It is concluded the need to redress unidosis carts and a computerized prescription system to avoid errors in transcription.Discussion: A high percentage of medication errors is caused by human error. If unidosis carts are overlooked before sent to hospitalization units, the error diminishes to 0.3%.

  3. Fan Cart: The Next Generation

    Science.gov (United States)

    Lamore, Brian

    2016-01-01

    For years the fan cart has provided physics students with an excellent resource for exploring fundamental mechanics concepts such as acceleration, Newton's laws, impulse, momentum, work-energy, and energy conversions. "The Physics Teacher" has even seen some excellent do-it-yourself (DIY) fan carts and activities. If you are interested…

  4. S-wave velocity structure and site effect parameters derived from microtremor arrays in the Western Plain of Taiwan

    Science.gov (United States)

    Kuo, Chun-Hsiang; Chen, Chun-Te; Lin, Che-Min; Wen, Kuo-Liang; Huang, Jyun-Yan; Chang, Shun-Chiang

    2016-10-01

    In this study, microtremor array measurements were conducted at 45 sites in the Western Plain of Taiwan. The arrays were approximately 30 m or 60 m in radius, depending on the site. The maximum-likelihood frequency-wavenumber method was adopted to obtain the phase velocities of Rayleigh waves, and then a genetic algorithm technique based on an inversion scheme of the fundamental mode of the Rayleigh waves' dispersion curves was applied to calculate a preliminary S-wave velocity (Vs) profile at each site. Because a layer of thick sediment covers the bedrock in the Western Plain of Taiwan, microtremor arrays in this size range cannot estimate the structure of the entire sediment. Therefore, this study implemented further inversion of the horizontal-to-vertical spectral ratios of the microtremors to estimate the deeper structures up to the bedrock of Vs greater than 1000 m/s. Previously logged velocity profiles for different depths at or near our study sites were collected and compared with the Vs profiles derived from our microtremor array measurements; the results were found to be highly comparable. Therefore, we could delineate the depth distributions for the layer depths for Vs = 600 m/s and 1000 m/s in this region. The depth for Vs = 600 m/s is approximately 50 m in the piedmont area and approximately 300 m at the coastline; moreover, the depths for Vs = 1000 m/s increase from 200 m in the piedmont area to approximately 1000 m at the coastline. The depths for Vs = 1.0 km/s (Z1.0), which is an important parameter that accounts for the basin effect in recent ground motion prediction equations, are consequently available at the study sites. The distribution of Z1.0 as a function of Vs30 indicates higher similarity to that in Japan than in the San Francisco Bay area.

  5. Cart with oxen

    OpenAIRE

    2016-01-01

    A black and white photograph showing two carts and two oxen. One of the oxen is standing and the other is resting on the ground - Μαυρόασπρη φωτογραφία που δείχνει δύο καρότσια και δύο βόδια. Το ένα βόδι στέκεται και το άλλο ξαπλώνει στο έδαφος.

  6. FMIT alignment cart

    Energy Technology Data Exchange (ETDEWEB)

    Potter, R.C.; Dauelsberg, L.B.; Clark, D.C.; Grieggs, R.J.

    1981-01-01

    The Fusion Materials Irradiation Test (FMIT) Facility alignment cart must perform several functions. It must serve as a fixture to receive the drift-tube girder assembly when it is removed from the linac tank. It must transport the girder assembly from the linac vault to the area where alignment or disassembly is to take place. It must serve as a disassembly fixture to hold the girder while individual drift tubes are removed for repair. It must align the drift tube bores in a straight line parallel to the girder, using an optical system. These functions must be performed without violating any clearances found within the building. The bore tubes of the drift tubes will be irradiated, and shielding will be included in the system for easier maintenance.

  7. A la Carte Community

    DEFF Research Database (Denmark)

    Gundelach, Peter; Brincker, Benedikte

    2010-01-01

    The exchange of open source software is a phenomenon that is becoming in- creasingly significant to IT users. This article presents the results of a study of the TYPO3 community, a community related to an open source CMS software. The article explores the community, identity and values of TYPO3...... and shows that there are high levels of virtual as well as face-to-face interaction among the members. The participants feel that they belong to the community and many also feel that they are recognised as part of the community. However, the members do not share common values neither in relation to software...... pro- duction nor generally. Instead, they stress that you are free to choose your own values. Against this background, the authors introduce the notion of an ‘a la carte community', i.e. a community where individuals pick and choose their degree of participation and integra- tion into the community...

  8. Data assimilation of a ten-day period during June 1993 over the Southern Great Plains Site using a nested mesoscale model

    Energy Technology Data Exchange (ETDEWEB)

    Dudhia, J.; Guo, Y.R. [National Center for Atmospheric Research, Boulder, CO (United States)

    1996-04-01

    A goal of the Atmospheric Radiation Measurement (ARM) Program has been to obtain a complete representation of physical processes on the scale of a general circulation model (GCM) grid box in order to better parameterize radiative processes in these models. Since an observational network of practical size cannot be used alone to characterize the Cloud and Radiation Testbed (CART) site`s 3D structure and time development, data assimilation using the enhanced observations together with a mesoscale model is used to give a full 4D analysis at high resolution. The National Center for Atmospheric Research (NCAR)/Penn State Mesoscale Model (MM5) has been applied over a ten-day continuous period in a triple-nested mode with grid sizes of 60, 20 and 6.67 in. The outer domain covers the United States` 48 contiguous states; the innermost is a 480-km square centered on Lamont, Oklahoma. A simulation has been run with data assimilation using the Mesoscale Analysis and Prediction System (MAPS) 60-km analyses from the Forecast Systems Laboratory (FSL) of the National Ocean and Atmospheric Administration (NOAA). The nested domains take boundary conditions from and feed back continually to their parent meshes (i.e., they are two-way interactive). As reported last year, this provided a simulation of the basic features of mesoscale events over the CART site during the period 16-26 June 1993 when an Intensive Observation Period (IOP) was under way.

  9. Trends and Extremes Analysis of Daily Weather Data from a Site in the Capitanata Plain (Southern Italy

    Directory of Open Access Journals (Sweden)

    Domenico Vitale

    2010-06-01

    Full Text Available The impacts of the climate change for agriculture is an ambitious and unresolved topic due to the complexity of the natural phenomena. The high variability of the Mediterranean basin does not allow us to generalize with enough certainty the results obtained from other researches and other locations. Therefore, a site specific analysis in Capitanata plain was conducted. The aim is to provide a detailed picture of recent change in climate regime in one of the most important agricultural area of South Italy. Climate analysis was carried out and several indices of extreme events were studied on the basis of temperature and precipitation observations registered at experimental station ‘Podere 124’ (CRA-SCA. The period under study is 1979-2008. Increasing trends were identified for the summer season with an intensification of the number of heat waves.

  10. Regulation of granulosa cell cocaine and amphetamine regulated transcript (CART) binding and effect of CART signaling inhibitor on granulosa cell estradiol production during dominant follicle selection in cattle.

    Science.gov (United States)

    Folger, Joseph K; Jimenez-Krassel, Fermin; Ireland, James J; Lv, Lihua; Smith, George W

    2013-12-01

    We previously established a potential role for cocaine and amphetamine regulated transcript (CARTPT) in dominant follicle selection in cattle. CARTPT expression is elevated in subordinate versus dominant follicles, and treatment with the mature form of the CARTPT peptide (CART) decreases follicle-stimulating hormone (FSH)-stimulated granulosa cell estradiol production in vitro and follicular fluid estradiol and granulosa cell CYP19A1 mRNA in vivo. However, mechanisms that regulate granulosa cell CART responsiveness are not understood. In this study, we investigated hormonal regulation of granulosa cell CART-binding sites in vitro and temporal regulation of granulosa cell CART-binding sites in bovine follicles collected at specific stages of a follicular wave. We also determined the effect of inhibition of CART receptor signaling in vivo on estradiol production in future subordinate follicles. Granulosa cell CART binding in vitro was increased by FSH, and this induction was blocked by estrogen receptor antagonist treatment. In follicles collected in vivo at specific stages of a follicular wave, granulosa cell CART binding in the F2 (second largest), future subordinate follicle increased during dominant follicle selection. Injection into the F2 follicle (at onset of diameter deviation) of an inhibitor of the o/i subclass of G proteins (previously shown to block CART actions in vitro) resulted in increased follicular fluid estradiol concentrations in vivo. Collectively, results demonstrate hormonal regulation of granulosa cell CART binding in vitro and temporal regulation of CART binding in subordinate follicles during dominant follicle selection. Results also suggest that CART signaling may help suppress estradiol-producing capacity of the F2 (subordinate) follicle during this time period.

  11. The rain-powered cart

    Science.gov (United States)

    Mungan, Carl E.; Lipscombe, Trevor C.

    2016-09-01

    A frictionless cart in the shape of a right triangle (with the vertical side forward) is elastically impacted by vertically falling raindrops. The speed of the cart as a function of time can be analytically deduced as an exercise in the use of trigonometric and hyperbolic functions. A characteristic time defines the approach to a terminal speed which is a sizeable fraction of the speed of the rain. The treatment is accessible to a student in a calculus-based mechanics course.

  12. Evaluation of nocturnal roost and diurnal sites used by whooping cranes in the Great Plains, United States

    Science.gov (United States)

    Pearse, Aaron T.; Harner, Mary J.; Baasch, David M.; Wright, Greg D.; Caven, Andrew J.; Metzger, Kristine L.

    2017-01-17

    Endangered whooping cranes (Grus americana) of the Aransas-Wood Buffalo population migrate through the Great Plains twice each year. Although there is much interest in conservation and management for this species, information regarding characteristics of nocturnal roost sites used during migration has been limited and based largely on incidental observations. Using high-quality location data collected concurrently, we directed a companion field study designed to characterize sites used as roost or day-use sites to augment knowledge and assist the Platte River Recovery Implementation Program in identifying migration habitat for restoration, conservation, and management actions along the Platte River in central Nebraska. We collected data at 504 roost sites and 83 day-use sites used by marked whooping cranes in Texas, Oklahoma, Kansas, Nebraska, South Dakota, North Dakota, Minnesota, and Montana. Roost sites were located in emergent wetlands (50 percent), lacustrine wetlands (25 percent), rivers (20 percent), and dryland sites (5 percent). Most day-use sites were characterized as dryland sites (54 percent), with the balance in wetlands (45 percent) and rivers (1 percent). Habitat criteria thresholds initially derived by the Platte River Recovery Implementation Program to represent where 90 percent of whooping cranes used along the Platte River were different from those we measured over a larger section of the migration corridor. For most of the metrics, the Platte River Recovery Implementation Program’s initial habitat criteria thresholds would be considered more conservative than critical values estimated from our data; thus, whooping cranes were seemingly able to tolerate a wider range of these metrics than initially suspected. One exception was the metric distance to nearest disturbance feature, where our results sug­gest that whooping cranes may be less tolerant to nearby dis­turbances in a larger part of the migration corridor compared to the Platte River

  13. Soil change and loblolly pine (Pinus taeda) seedling growth following site preparation tillage in the Upper Coastal Plain of the southeastern United States

    Science.gov (United States)

    Chad M. Lincoln; Rodney E. Will; Lawrence A. Morris; Emily A. Carter; Daniel Markewtiz; John R. Britt; Ben Cazell; Vic Ford

    2007-01-01

    To determine the relationship between changes in soil physical properties due to tillage and growth of loblolly pine (Pinus taeda L.) seedlings, we measured soil moisture and penetration resistance for a range of tillage treatments on two Upper Coastal Plain sites in Georgia and correlated these measurements to the growth of individual seedlings. The...

  14. Innovative strategies for high resolution site characterization: application to a flood plain

    Directory of Open Access Journals (Sweden)

    Thomas Vienken

    2014-12-01

    Full Text Available Solving complex hydrogeological problems often requires a thorough understanding of (hydro- geological subsurface conditions. This is especially true for sedimentary deposits with complex architecture, where lithology and/or hydraulic properties can significantly vary over short horizontal and vertical distances. At these sites, a traditional, solely sample-based investigation approach is often not applicable due to limited data accuracy, resolution, and efficiency. Instead, an adapted investigation approach is required that combines exploration technologies of different resolution and investigation scales. This paper aims to demonstrate the feasibility of such a multi-scale approach for the characterization of a test site near the city of Löbnitz, Germany, that is comprised of heterogeneous alluvial deposits. Our focus is on site characterization in terms of lithology and hydraulic properties, as well as on the delineation and characterization of an aggradated oxbow as a typical example of a small scale geological structure.

  15. Understanding Land-Atmosphere Coupling and its Predictability at the ARM Southern Great Plains Site

    Science.gov (United States)

    Ferguson, C. R.; Song, H. J.; Roundy, J. K.

    2015-12-01

    Ten years ago, the Global Energy and Water EXchanges Global Land Atmosphere Coupling Experiment (GLACE) spotlighted the Southern Great Plains (SGP) for being one of three hotspots globally for land-derived precipitation predictability. Since then, the GLACE results have served as the underlying motivation for numerous subsequent land-atmosphere (L-A) coupling studies over the SGP domain. The range of these studies includes: local point scale studies leveraging surface meteorological and flux measurements at the U.S. Department of Energy (DOE) Atmospheric Radiation Measurement SGP (ARM-SGP) Central Facility, regional pentad to monthly scale atmospheric moisture budget analyses based on atmospheric reanalysis, and regional limited duration (2-7 day) coupled model sensitivity experiments. This study has the following three objectives: (1) to provide the common historical context necessary for bridging past and future interdisciplinary characterizations of L-A coupling, (2) to isolate the mechanism(s) for the region's L-A coupling signal, and (3) to evaluate the short range (12-18hr) predictability of soil moisture-precipitation feedbacks. We produce a convective triggering potential—low-level humidity index (CTP-HI)—based climatology of L-A coupling at ARM-SGP for the period 1979-2014 using North American Regional Reanalysis and North American Land Data Assimilation System Phase 2 data. We link the underlying coupling regime classification timeseries to corresponding synoptic-mesoscale weather patterns and bulk atmospheric moisture budget analyses. On the whole, the region's precipitation variability is largely dependent on large-scale moisture transport and the role of the land is nominal. However, we show that surface sensible heat flux can play an important role in modulating diurnal precipitation cycle phase and amplitude—either directly (enhancing CTP) in water-limited conditions or indirectly (increasing HI) in energy-limited conditions. In fact, both 0700

  16. Microgravity vertical gradient measurement in the site of VIRGO interferometric antenna (Pisa plain, Italy

    Directory of Open Access Journals (Sweden)

    F. Fidecaro

    2008-06-01

    Full Text Available The site of the European Gravitational Observatory (EGO located in the countryside near Pisa (Tuscany, Italy was investigated by a microgravity vertical gradient (MVG survey. The EGO site houses the VIRGO interferometric antenna for gravitational waves detection. The microgravity survey aims to highlight the gravity anomalies of high-frequency related to more superficial geological sources in order to obtain a detailed model of the lithologic setting of the VIRGO site, that will allow an estimate of the noise induced by seismic waves and by Newtonian interference. This paper presents the results of the gradiometric survey of 2006 in the area of the interferometric antenna. MVG measurements allow us to enhance the high frequency signal strongly associated with the shallow structures. The gradient gravity map shows a main negative pattern that seems related to the trending of the high density layer of gravel that was evidenced in geotechnical drillings executed along the orthogonal arms during the construction of the VIRGO complex. Calibrating the relationship between the vertical gradient and the depth of the gravel interface we have computed a model of gravity gradient for the whole VIRGO site, defining the 3D distribution of the top surface of this layer. This latter shows a NE-SW negative pattern that may represent a palaeo-bed alluvial of the Serchio from the Bientina River system.

  17. Clear Sky Identification Using Data From Remote Sensing Systems at ARM's Southern Great Plains Site

    Energy Technology Data Exchange (ETDEWEB)

    Delle Monache, L.; Rodriguez, D.; Cederwall, R.

    2000-06-27

    Clouds profoundly affect our weather and climate due, in large part, to their interactions with radiation. Unfortunately, our understanding of these interactions is, at best, incomplete, making it difficult to improve the treatment of atmospheric radiation in climate models. The improved treatment of clouds and radiation, and a better understanding of their interaction, in climate models is one of the Department of Energy's Atmospheric Radiation Measurement (ARM) Program's major goals. To learn more about the distribution of water and ice, i.e., clouds, within an atmospheric column, ARM has chosen to use the remote sensing of clouds, water vapor and aerosols at its three climatologically-diverse sites as its primary observational method. ARM's most heavily instrumented site, which has operated continuously for more than a decade, is its Southern Great Plains (SGP) Central Facility, located near Lamont, OK. Cloud-observing instruments at the Central Facility include the Whole Sky Imager, ceilometers, lidar, millimeter cloud radar, microwave radiometers and radiosondes.

  18. Summertime Low-Level Jets over the Great Plains

    Energy Technology Data Exchange (ETDEWEB)

    Stensrud, D.J. [NOAA/ERL/National Severe Storms Lab., Norman, OK (United States); Pfeifer, S. [Univ. of Oklahoma, Norman, OK (United States)

    1996-04-01

    The sky over the southern Great Plains Cloud and Atmospheric Radiation Testbed (CART) site of the Atmospheric Radiation Measurement (ARM) Program during the predawn and early morning hours often is partially obstructed by stratocumulus, stratus fractus, or cumulus fractus that are moving rapidly to the north, even through the surface winds are weak. This cloud movement is evidence of the low-level jet (LLJ), a wind speed maximum that occurs in the lowest few kilometers of the atmosphere. Owing to the wide spacing between upper-air sounding sites and the relatively infrequent sounding launches, LLJ evolution has been difficult to observe adequately, even though the effects of LLJs on moisture flux into North America are large. Model simulation of the LLJ is described.

  19. FPC conditioning cart at BNL

    Energy Technology Data Exchange (ETDEWEB)

    Xu, W.; Ben-Zvi, I.; Altinbas, F.Z.; Belomestnykh, S.; Burrill, A.; Cole, M.; Deonarine, J.; Jamilkowski, J.; Kayran, D.; Laloudakis, N.; Masi Jr, L.; McIntyre, G.; Pate, D.; Philips, D.; Seda, T.; Steszyn, A.; Tallerico, T.; Todd, R.; Weiss, D.; White, G.; Zaltsman, A.

    2011-03-28

    The 703 MHz superconducting gun for the BNL Energy Recovery Linac (ERL) prototype has two fundamental power couplers (FPCs), and each of them will deliver up to 500 kW of CW RF power. In order to prepare the couplers for high power RF service and process multipacting, the FPCs should be conditioned prior to installation into the gun cryomodule. A conditioning cart based test stand, which includes a vacuum pumping system, controllable bake-out system, diagnostics, interlocks and data log system has been designed, constructed and commissioned by collaboration of BNL and AES. This paper presents FPC conditioning cart systems and the conditioning process.

  20. 2011 ESTCP Live Site Demonstrations, Marysville, CA. ESTCP MR-1165, Demonstration Data Report, Former Camp Beale, TEMTADS MP 2x2 Cart Survey

    Science.gov (United States)

    2011-10-20

    31  Figure 10-1 – Management and Staffing Wiring Diagram . ...........................................................32  Tables...activities is provided in Figure 5-1 as a Gantt chart. Figure 5-1 – Schedule of Field Testing Activities Activity Name 5 12 19 Jun 2011 5 12 19 Camp...Matthew Barner and Andrew Louder served as Data Acquisition Operators. Figure 10-1 – Management and Staffing Wiring Diagram . Site / Project Supervisor

  1. High concentrations and dry deposition of reactive nitrogen species at two sites in the North China Plain

    Energy Technology Data Exchange (ETDEWEB)

    Shen, J.L.; Tang, A.H.; Liu, X.J.; Fangmeier, A.; Goulding, K.T.W.; Zhang, F.S. [China Agricultural University, Beijing (China)

    2009-11-15

    Atmospheric concentrations of major reactive nitrogen (N{sub r}) species were quantified using passive samplers, denuders, and particulate samplers at Dongbeiwang and Quzhou, North China Plain (NCP) in a two-year study. Average concentrations of NH{sub 3}, NO{sub 2}, HNO{sub 3}, pNH{sub 4}{sup +} and pNO{sub 3}{sup -} were 12.0, 12.9, 0.6, 10.3, and 4.7 {mu} g N m{sup -3} across the two sites, showing different seasonal patterns of these N, species. For example, the highest NH{sub 3} concentration occurred in summer while NO{sub 2} concentrations were greater in winter, both of which reflected impacts of N fertilization (summer) and coal-fueled home heating (winter). Based on measured N{sub r} concentrations and their deposition velocities taken from the literature, annual N dry deposition was up to 55 kg N ha{sup -1}. Such high concentrations and deposition rates of N{sub r} species in the NCP indicate very serious air pollution from anthropogenic sources and significant atmospheric N input to crops.

  2. Comparison of Vaisala radiosondes RS41 and RS92 at the ARM Southern Great Plains site

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, Michael P.; Holdridge, Donna J.; Survo, Petteri; Lehtinen, Raisa; Baxter, Shannon; Toto, Tami; Johnson, Karen L.

    2016-06-20

    In the fall of 2013, the Vaisala RS41 (fourth generation) radiosonde was introduced as a replacement for the RS92-SGP radiosonde with improvements in measurement accuracy of profiles of atmospheric temperature, humidity, and pressure. In order to help characterize these improvements, an intercomparison campaign was undertaken at the US Department of Energy's Atmospheric Radiation Measurement (ARM) Climate Research Facility site in north-central Oklahoma, USA. During 3–8 June 2014, a total of 20 twin-radiosonde flights were performed in a variety of atmospheric conditions representing typical midlatitude continental summertime conditions. The results show that for most of the observed conditions the RS92 and RS41 measurements agree much better than the manufacturer-specified combined uncertainties with notable exceptions when exiting liquid cloud layers where the “wet-bulbing” effect appears to be mitigated for several cases in the RS41 observations. The RS41 measurements of temperature and humidity, with applied correction algorithms, also appear to show less sensitivity to solar heating. These results suggest that the RS41 does provide important improvements, particularly in cloudy conditions. For many science applications – such as atmospheric process studies, retrieval development, and weather forecasting and climate modeling – the differences between the RS92 and RS41 measurements should have little impact. However, for long-term trend analysis and other climate applications, additional characterization of the RS41 measurements and their relation to the long-term observational records will be required.

  3. Lower tropospheric distributions of O3 and aerosol over Raoyang, a rural site in the North China Plain

    Science.gov (United States)

    Wang, Rui; Xu, Xiaobin; Jia, Shihui; Ma, Ruisheng; Ran, Liang; Deng, Zhaoze; Lin, Weili; Wang, Ying; Ma, Zhiqiang

    2017-03-01

    The North China Plain (NCP) has become one of the most polluted regions in China, with the rapidly increasing economic growth in the past decades. High concentrations of ambient O3 and aerosol have been observed at urban as well as rural sites in the NCP. Most of the in situ observations of air pollutants have been conducted near the ground so that current knowledge about the vertical distributions of tropospheric O3 and aerosol over the NCP region is still limited. In this study, vertical profiles of O3 and size-resolved aerosol concentrations below 2.5 km were measured in summer 2014 over a rural site in the NCP, using an unmanned aerial vehicle (UAV) equipped with miniature analyzers. In addition, vertical profiles of aerosol scattering property in the lower troposphere and vertical profiles of O3 below 1 km were also observed at the site using a lidar and tethered balloon, respectively. The depths of the mixed layer and residual layer were determined according to the vertical gradients of lidar particle extinction and aerosol number concentration. Average O3 and size-resolved aerosol number concentration in both the mixed and residual layer were obtained from the data observed in seven UAV flights. The results show that during most of the flights the O3 levels above the top of mixed layer were higher than those below. Such a positive gradient in the vertical distribution of O3 makes the residual layer an important source of O3 in the mixed layer, particularly during the morning when the top of mixed layer is rapidly elevated. In contrast to O3, aerosol number concentration was normally higher in the mixed layer than in the residual layer, particularly in the early morning. Aerosol particles were overwhelmingly distributed in the size range pollutants locally emitted or transported from urban areas. Compared with the historic O3 vertical profiles over Beijing from the Measurement of Ozone and Water Vapor by Airbus In-Service Aircraft (MOZAIC), a strong increase

  4. Efficacy of plain radiography and computer tomography in localizing the site of pelvic arterial bleeding in trauma patients

    Energy Technology Data Exchange (ETDEWEB)

    Dormagen, Johann B. (Dept. of Radiology, Oslo Univ. Hospital, Ullevaal, Oslo (Norway)), e-mail: johannd@medisin.uio.no; Toetterman, Anna (Dept. of Orthopedic Surgery, Uppsala Univ. Hospital, Uppsala (Sweden)); Roeise, Olav (Div. of Neuroscience and Musculoskeletal Medicine, Oslo Univ. Hospital, Ullevaal, Oslo (Norway)); Sandvik, Leiv (Center for Clinical Research, Oslo Univ. Hospital, Ullevaal, Oslo (Norway)); Kloew, Nils-E. (Dept. of Cardiovascular Radiology, Oslo Univ. Hospital - Ullevaal, Oslo (Norway))

    2010-01-15

    Background: Immediate angiography is warranted in pelvic trauma patients with suspected arterial injury (AI) in order to stop ongoing bleeding. Prior to angiography, plain pelvic radiography (PPR) and abdominopelvic computer tomography (CT) are performed to identify fracture and hematoma sites. Purpose: To investigate if PPR and CT can identify the location of AI in trauma patients undergoing angiography. Material and Methods: 95 patients with pelvic fractures on PPR (29 women, 66 men), at a mean age of 44 (9-92) years, underwent pelvic angiography for suspected AI. Fifty-six of them underwent CT additionally. Right and left anterior and posterior fractures on PPR were registered, and fracture displacement was recorded for each quadrant. Arterial blush on CT was registered, and the size of the hematoma in each region was measured in cm2. AIs were registered for anterior and posterior segments of both internal iliac arteries. Presence of fractures, arterial blush, and hematomas were correlated with AI. Results: Presence of fracture in the corresponding skeletal segment on PPR showed sensitivity and specificity of 0.86 and 0.58 posteriorly, and 0.87 and 0.44 anteriorly. The area under the curve (AUC) was 0.77 and 0.69, respectively. Fracture displacement on PPR >0.9 cm posteriorly and >1.9 cm anteriorly revealed specificity of 0.84. Sensitivities of arterial blush and hematoma on CT were 0.38 and 0.82 posteriorly, and 0.24 and 0.82 anteriorly. The specificities were 0.96 and 0.58 posteriorly, and 0.79 and 0.53 anteriorly, respectively. For hematomas, the AUC was 0.79 posteriorly and 0.75 anteriorly. Size of hematoma >22 cm2 posteriorly and >29 cm2 anteriorly revealed specificity of 0.85 and 0.86, respectively. Conclusion: CT findings of arterial blush and hematoma predicted site of arterial bleeding on pelvic angiography. Also, PPR predicted the site of bleeding using location of fracture and size of displacement. In the hemodynamically unstable patient, PPR may

  5. Distribution pattern of CART-containing neurons and cells in the human pancreas.

    Science.gov (United States)

    Kasacka, Irena; Janiuk, Izabela; Lewandowska, Alicja; Bekisz, Agnieszka; Lebkowski, Wojciech

    2012-11-01

    Cocaine- and amphetamine-regulated transcript (CART) has been shown to play a critical role in appetite suppression, cell survival, thermoregulation, glucose sensing, stimulation of hormone secretion, as well as for the regulatory function of the islets of Langerhans. Although the principal site of CART synthesis has already been reported, our knowledge of the subject is mainly based on and limited to research conducted on animals owing to difficulties in obtaining human samples. Therefore, the primary goal of the reported study was an attempt to identify and localize CART in healthy human pancreas. Nineteen deceased subjects (donors of organs) with normal pancreas and alimentary tract were used in the study. After determination of brain death and confirmation of death by the relevant doctors committee, pancreas samples, about 1cm long, were collected from each corpse (the same part of the pancreas) after the organs were harvested for transplantation. Paraffin sections were made and stained with hematoxylin and eosin and then subjected to CART immunohistochemistry. In the normal pancreas of human adults, CART is mainly present in both nerve fibers and in nerve cell bodies in pancreatic ganglia. In addition to pancreatic neurons, immunoreactivity to CART was also seen in islet endocrine cells. This is the first report on the presence of CART-IR structures in the normal human pancreas. CART should be now added to the numerous regulatory peptides that are involved in the complex regulation of pancreatic endocrine and exocrine processes.

  6. Identification and location of the cocaine and amphetamine regulated transcript (CART) in the abomasum of cattle.

    Science.gov (United States)

    Janiuk, Izabela; Młynek, Krzysztof; Wysocki, Jarosław

    2013-05-01

    The cocaine and amphetamine regulated transcript (CART) belongs to the group of peptides with anorexigenic properties and is present in many areas of the central and peripheral nervous systems of numerous mammalian species. Research has suggested an effect on the feeling of appetite and satiety; however, there are no clear clues as to the role of CART in specific organs, including the stomach. Considering the specificity of cattle feeding and digestion, CART may play a highly significant role possibly associated with the option of administering greater amounts of high-volume feeds. Based on the results of immunohistochemical staining of abomasum samples prepared from hybrid bulls, the presence of CART-positive structures and CART distribution were determined in the mucosa, submucosa and muscularis layers of the stomach. Abundant sites of CART were found in the myenteric plexus, nerve fibers innervating the myocytes of the myenteron, neuroendocrine cells of the diffuse neuroendocrine system and the submucous plexus. The preliminary stage of abomasal CART detection suggests that CART is an agent that strongly affects the regulation of motor activity involved in stomach emptying and in secretory functions of the stomach. However, further research is necessary to explain the relationship.

  7. OH reactivity at a rural site (Wangdu) in the North China Plain: contributions from OH reactants and experimental OH budget

    Science.gov (United States)

    Fuchs, Hendrik; Tan, Zhaofeng; Lu, Keding; Bohn, Birger; Broch, Sebastian; Brown, Steven S.; Dong, Huabin; Gomm, Sebastian; Häseler, Rolf; He, Lingyan; Hofzumahaus, Andreas; Holland, Frank; Li, Xin; Liu, Ying; Lu, Sihua; Min, Kyung-Eun; Rohrer, Franz; Shao, Min; Wang, Baolin; Wang, Ming; Wu, Yusheng; Zeng, Limin; Zhang, Yinson; Wahner, Andreas; Zhang, Yuanhang

    2017-01-01

    In 2014, a large, comprehensive field campaign was conducted in the densely populated North China Plain. The measurement site was located in a botanic garden close to the small town Wangdu, without major industry but influenced by regional transportation of air pollution. The loss rate coefficient of atmospheric hydroxyl radicals (OH) was quantified by direct measurements of the OH reactivity. Values ranged between 10 and 20 s-1 for most of the daytime. Highest values were reached in the late night with maximum values of around 40 s-1. OH reactants mainly originated from anthropogenic activities as indicated (1) by a good correlation between measured OH reactivity and carbon monoxide (linear correlation coefficient R2 = 0.33) and (2) by a high contribution of nitrogen oxide species to the OH reactivity (up to 30 % in the morning). Total OH reactivity was measured by a laser flash photolysis-laser-induced fluorescence instrument (LP-LIF). Measured values can be explained well by measured trace gas concentrations including organic compounds, oxygenated organic compounds, CO and nitrogen oxides. Significant, unexplained OH reactivity was only observed during nights, when biomass burning of agricultural waste occurred on surrounding fields. OH reactivity measurements also allow investigating the chemical OH budget. During this campaign, the OH destruction rate calculated from measured OH reactivity and measured OH concentration was balanced by the sum of OH production from ozone and nitrous acid photolysis and OH regeneration from hydroperoxy radicals within the uncertainty of measurements. However, a tendency for higher OH destruction compared to OH production at lower concentrations of nitric oxide is also observed, consistent with previous findings in field campaigns in China.

  8. A comparison of cloud layers from ground and satellite active remote sensing at the Southern Great Plains ARM site

    Science.gov (United States)

    Zhang, Jinqiang; Xia, Xiang'ao; Chen, Hongbin

    2017-03-01

    Using the data collected over the Southern Great Plains ARM site from 2006 to 2010, the surface Active Remote Sensing of Cloud (ARSCL) and CloudSat-CALIPSO satellite (CC) retrievals of total cloud and six specified cloud types [low, mid-low (ML), high-mid-low (HML), mid, high-mid (HM) and high] were compared in terms of cloud fraction (CF), cloud-base height (CBH), cloud-top height (CTH) and cloud thickness (CT), on different temporal scales, to identify their respective advantages and limitations. Good agreement between the two methods was exhibited in the total CF. However, large discrepancies were found between the cloud distributions of the two methods at a high (240-m) vertical grid spacing. Compared to the satellites, ARSCL retrievals detected more boundary layer clouds, while they underestimated high clouds. In terms of the six specific cloud types, more low- and mid-level clouds but less HML- and high-level clouds were detected by ARSCL than by CC. In contrast, the ARSCL retrievals of ML- and HM-level clouds agreed more closely with the estimations from the CC product. Lower CBHs tended to be reported by the surface data for low-, ML- and HML-level clouds; however, higher CTHs were often recorded by the satellite product for HML-, HM- and high-level clouds. The mean CTs for low- and ML-level cloud were similar between the two products; however, the mean CTs for HML-, mid-, HM- and high-level clouds from ARSCL were smaller than those from CC.

  9. Evaluation of meteorites as habitats for terrestrial microorganisms: Results from the Nullarbor Plain, Australia, a Mars analogue site

    Science.gov (United States)

    Tait, Alastair W.; Wilson, Siobhan A.; Tomkins, Andrew G.; Gagen, Emma J.; Fallon, Stewart J.; Southam, Gordon

    2017-10-01

    Unambiguous identification of biosignatures on Mars requires access to well-characterized, long-lasting geochemical standards at the planet's surface that can be modified by theoretical martian life. Ordinary chondrites, which are ancient meteorites that commonly fall to the surface of Mars and Earth, have well-characterized, narrow ranges in trace element and isotope geochemistry compared to martian rocks. Given that their mineralogy is more attractive to known chemolithotrophic life than the basaltic rocks that dominate the martian surface, exogenic rocks (e.g., chondritic meteorites) may be good places to look for signs of prior life endemic to Mars. In this study, we show that ordinary chondrites, collected from the arid Australian Nullarbor Plain, are commonly colonized and inhabited by terrestrial microorganisms that are endemic to this Mars analogue site. These terrestrial endolithic and chasmolithic microbial contaminants are commonly found in close association with hygroscopic veins of gypsum and Mg-calcite, which have formed within cracks penetrating deep into the meteorites. Terrestrial bacteria are observed within corrosion cavities, where troilite (FeS) oxidation has produced jarosite [KFe3(SO4)2(OH)6]. Where terrestrial microorganisms have colonized primary silicate minerals and secondary calcite, these mineral surfaces are heavily etched. Our results show that inhabitation of meteorites by terrestrial microorganisms in arid environments relies upon humidity and pH regulation by minerals. Furthermore, microbial colonization affects the weathering of meteorites and production of sulfate, carbonate, Fe-oxide and smectite minerals that can preserve chemical and isotopic biosignatures for thousands to millions of years on Earth. Meteorites are thus habitable by terrestrial microorganisms, even under highly desiccating environmental conditions of relevance to Mars. They may therefore be useful as chemical and isotopic ;standards; that preserve evidence of

  10. Observation of atmospheric peroxides during Wangdu Campaign 2014 at a rural site in the North China Plain

    Science.gov (United States)

    Wang, Yin; Chen, Zhongming; Wu, Qinqin; Liang, Hao; Huang, Liubin; Li, Huan; Lu, Keding; Wu, Yusheng; Dong, Huabin; Zeng, Limin; Zhang, Yuanhang

    2016-09-01

    Measurements of atmospheric peroxides were made during Wangdu Campaign 2014 at Wangdu, a rural site in the North China Plain (NCP) in summer 2014. The predominant peroxides were detected to be hydrogen peroxide (H2O2), methyl hydroperoxide (MHP) and peroxyacetic acid (PAA). The observed H2O2 reached up to 11.3 ppbv, which was the highest value compared with previous observations in China at summer time. A box model simulation based on the Master Chemical Mechanism and constrained by the simultaneous observations of physical parameters and chemical species was performed to explore the chemical budget of atmospheric peroxides. Photochemical oxidation of alkenes was found to be the major secondary formation pathway of atmospheric peroxides, while contributions from alkanes and aromatics were of minor importance. The comparison of modeled and measured peroxide concentrations revealed an underestimation during biomass burning events and an overestimation on haze days, which were ascribed to the direct production of peroxides from biomass burning and the heterogeneous uptake of peroxides by aerosols, respectively. The strengths of the primary emissions from biomass burning were on the same order of the known secondary production rates of atmospheric peroxides during the biomass burning events. The heterogeneous process on aerosol particles was suggested to be the predominant sink for atmospheric peroxides. The atmospheric lifetime of peroxides on haze days in summer in the NCP was about 2-3 h, which is in good agreement with the laboratory studies. Further comprehensive investigations are necessary to better understand the impact of biomass burning and heterogeneous uptake on the concentration of peroxides in the atmosphere.

  11. Integrated evaluation of aerosols during haze-fog episodes at one regional background site in North China Plain

    Science.gov (United States)

    Yuan, Qi; Li, Weijun; Zhou, Shengzhen; Yang, Lingxiao; Chi, Jianwei; Sui, Xiao; Wang, Wenxing

    2015-04-01

    To investigate haze-fog (HF) formation mechanisms and transport, trace gases and aerosols in the aged air masses during regional haze episodes were measured at a regional background site in the North China Plain during 4-19 July, 2011. Mixing state of individual particles, soluble ions of PM2.5, and particle number concentrations were studied using transmission electron microscope, ambient ion monitoring, and wide-range particle spectrometer, respectively. Average mass concentration of PM2.5 was 3 times higher on HF days (70 μg/m3) than on clear days (22 μg/m3). The major soluble ionic components (SO42 -, NO3-, and NH4+) in PM2.5 were over 4 times higher on HF days (40.6 μg/m3) than on clear days (9.1 μg/m3). The high sulfur oxidation ratios (SOR) and nitrogen oxidation ratios (NOR) values during HF days suggest that polluted weather favored transformation of SO2 and NOx into sulfates and nitrates compared to clear days. Particle number fraction of the accumulation mode increases from 11% on clear days up to 26% on HF days. Individual particle analysis shows that secondary inorganic particles (e.g., sulfate and nitrate) as the most abundant species likely determine internal mixing of individual particles and almost half of them mixed refractory particles (e.g., metal, fly ash, soot, and mineral) on HF days. These fine refractory particles were likely emitted from coal fired power plants, heavy industries, and urban city in Shandong and Hebei provinces. Our results suggest that aged air masses mostly contain aged particles of long-range transport and some from new particle formation and growth in the regional background atmosphere.

  12. CART peptide induces neuroregeneration in stroke rats.

    Science.gov (United States)

    Luo, Yu; Shen, Hui; Liu, Hua-Shan; Yu, Seong-Jin; Reiner, David J; Harvey, Brandon K; Hoffer, Barry J; Yang, Yihong; Wang, Yun

    2013-02-01

    Utilizing a classic stroke model in rodents, middle cerebral artery occlusion (MCAo), we describe a novel neuroregenerative approach using the repeated intranasal administration of cocaine- and amphetamine-regulated transcript (CART) peptide starting from day 3 poststroke for enhancing the functional recovery of injured brain. Adult rats were separated into two groups with similar infarction sizes, measured by magnetic resonance imaging on day 2 after MCAo, and were treated with CART or vehicle. The CART treatment increased CART level in the brain, improved behavioral recovery, and reduced neurological scores. In the subventricular zone (SVZ), CART enhanced immunolabeling of bromodeoxyuridine, a neural progenitor cell marker Musashi-1, and the proliferating cell nuclear antigen, as well as upregulated brain-derived neurotrophic factor (BDNF) mRNA. AAV-GFP was locally applied to the SVZ to examine migration of SVZ cells. The CART enhanced migration of GFP(+) cells from SVZ toward the ischemic cortex. In SVZ culture, CART increased the size of neurospheres. The CART-mediated cell migration from SVZ explants was reduced by anti-BDNF blocking antibody. Using (1)H-MRS (proton magnetic resonance spectroscopy), increases in N-acetylaspartate levels were found in the lesioned cortex after CART treatment in stroke brain. Cocaine- and amphetamine-regulated transcript increased the expression of GAP43 and fluoro-ruby fluorescence in the lesioned cortex. In conclusion, our data suggest that intranasal CART treatment facilitates neuroregeneration in stroke brain.

  13. Test and Check Out Cart (T.A.C.O. Cart)

    Science.gov (United States)

    2015-05-14

    Technical Briefing 3. DATES COVERED (From - To) 4. TITLE AND SUBTITLE Test and Check Out Cart (T.A.C.O. Cart ) 5a. CONTRACT NUMBER...This briefing will discuss the Test and Check-Out (TACO) cart . It is basically a mobile weatherproof laboratory. The primary purpose is to

  14. Des cartes dans la classe…

    Directory of Open Access Journals (Sweden)

    R. Gimeno

    1990-09-01

    Full Text Available La majorité des enseignants qui veulent faire des cartes — et les faire réaliser aux élèves — pour répondre aux exigences des instructions officielles, doivent surmonter leur manque de compétences en cartographie et en didactique ainsi que les difficultés propres aux logiciels de cartographie encore peu performants. Ces compétences et la réflexion qui les accompagne sont pourtant accessibles aux enfants de l’école élémentaire…

  15. Rolling Friction on a Wheeled Laboratory Cart

    Science.gov (United States)

    Mungan, Carl E.

    2012-01-01

    A simple model is developed that predicts the coefficient of rolling friction for an undriven laboratory cart on a track that is approximately independent of the mass loaded onto the cart and of the angle of inclination of the track. The model includes both deformation of the wheels/track and frictional torque at the axles/bearings. The concept of…

  16. The Ballistic Cart on an Incline Revisited.

    Science.gov (United States)

    Serway, Raymond A.; And Others

    1995-01-01

    Presents the theory behind the mechanics demonstration that involves projecting a ball vertically upward from a ballistic cart moving along an inclined plane. The measured overshoot is believed to be due, in part, to the presence of rolling friction and the inertial properties of the cart wheels. (JRH)

  17. Rolling Friction on a Wheeled Laboratory Cart

    Science.gov (United States)

    2012-01-01

    by gravity, and a vehicle (such as a car or bicycle ) accelerating along a level road is driven by a motor or by pedalling. In such cases, static...continuously roll. Consider a cart of mass m that is free rolling up an incline, as sketched in figure 1. The total frictional force f on the cart

  18. The Ballistic Cart on an Incline Revisited.

    Science.gov (United States)

    Serway, Raymond A.; And Others

    1995-01-01

    Presents the theory behind the mechanics demonstration that involves projecting a ball vertically upward from a ballistic cart moving along an inclined plane. The measured overshoot is believed to be due, in part, to the presence of rolling friction and the inertial properties of the cart wheels. (JRH)

  19. The small mammals of an upper piedmontese Po plain site (Leinì, Turin prov. / La micromammalofauna di una stazione planiziaria piemontese

    Directory of Open Access Journals (Sweden)

    Giuseppe Osella

    1986-12-01

    Full Text Available Abstract The 24 small mammals listed as living in Leinì (Piedmontese Po plain, near Turin, 245 m on sea level (only the red fox, Vulpes vulpes is not sure, are briefly analysed (Chiroptera excepted. List and analysis are the results of studies pursued for about 35 years. However, in Verona's Museum of Natural History, the housed materials are related to the last eighteen years (1966-1984 (Tab. I. For a complete analysis, this fauna is compared with the Veronese Po plain one, especially with the Busatello one (Gazzo Veronese-Ostiglia. This site is a stretch of marshes named "Valli Grandi Veronesi and Ostigliesi" (Tab. II. In this analysis, if we don't consider the not native species (Myocastor coypus and Mustela vison, the estinguished species (Lutra lutra, the Mediterranean species (living only along the border of the Po plain basin (Suncus etruscus and the hunting species (Lepus europaeus and Oryctolagus cuniculus we have 23 taxa for Lein and only 17 and 13, respectively, for Veronese Po plain and Busatello. The richer small mammal fauna of the Piedmontese Po plain is, above all, supported by different ecological conditions but the preservation of some species (e.g. Glis glis and Muscardinus avellanarius in Leinì is surely related also to historical problems and to a land anthropization pushed forward to a lesser degree. Riassunto Vengono elencate e brevemente commentate tutte le specie di micromammiferi presenti a Leinì (Torino, Chirotteri esclusi. Si tratta di un complesso di 24 specie (solo la volpe non è del tutto sicura per ognuna delle quali gli autori, sinteticamente, espongono le osservazioni raccolte in circa 35 anni. A maggior chiarimento del significato faunistico del popolamento, viene presa in esame anche la micromammalofauna della pianura padano veneta, precisamente la pianura veronese ed in particolar modo la

  20. Observation and modelling of ambient nitrous acid (HONO) at a rural site (Wangdu) in the North China Plain in summer 2014

    Science.gov (United States)

    Liu, Yuhan; Lu, Keding; Li, Xin; Dong, Huabin; Ye, Nini; Tan, Zhaofeng; Wu, Yusheng; Zeng, Liming; Bohn, Birger; Broch, Sebastian; Fuchs, Hendrik; Hofzumahaus, Andrease; Holland, Frank; Rohrer, Franz; Wahner, Andrease; Zhang, Yuanhang

    2016-04-01

    Significant missing daytime HONO sources were determined in many places worldwide from urban to rural conditions. In recent field campaigns performed in Chinese megacity regions such as Pearl River Delta, Yangtze River Delta and North China Plain, strong missing HONO sources were also determined and possible explanations including photoenhanced heterogeneous conversion of NO2, photolysis of particulate nitrate, soil emission, and emission from biomass burning. In the present work, we performed in situ measurements of ambient HONO concentration at a rural site (Wangdu) in North China Plain in summer 2014. The observed HONO concentration ranges from tens ppt to 5 ppb. The relations between observed HONO concentration and nitrogen oxide, aerosol and gas-phase chemistry are discussed with statistical methods. Moreover, we use an observational constrained box model to explore the possible roles of the state of art HONO production mechanisms. In addition, after the day of fertilization, we observed a daytime HONO peak around noon time which was distinct from other days by the HONO/NO2 ratio. We believe this peak is a strong indication of soil HONO emission since our site was located in center of a large wheat field. Compared to other days, this increased HONO concentration contributes significantly to the OH production around noontime.

  1. A CART extention using Quadratic Decision Borders

    DEFF Research Database (Denmark)

    Hartelius, Karsten

    1999-01-01

    In this article we put forward an extention to the hierarchical CART classification method which uses quadratic decision borders. The original CART applies univariate splits on individual variables as well as splits on combinations of variables to recursively partition the feature......-space into subsets which are successively more class-homogeneous. Guided by the fact that class-distributions in feature-space are very often hyper-elliptical shaped, we give an extension to the original CART which also uses quadratic shaped decision borders which can be modelled by a mean-vector and a dispersion...

  2. A CART extension using Quadratic Decision Borders

    DEFF Research Database (Denmark)

    Hartelius, Karsten

    1999-01-01

    In this article we put forward an extention to the hierarchical CART classification method which uses quadratic decision borders. The original CART applies univariate splits on individual variables as well as splits on combinations of variables to recursively partition the feature......-space into subsets which are successively more class-homogeneous. Guided by the fact that class-distributions in feature-space are very often hyper-elliptical shaped, we give an extension to the original CART which also uses quadratic shaped decision borders which can be modelled by a mean-vector and a dispersion...

  3. Low frequency amplification in deep alluvial basins: an example in the Po Plain (Northern Italy) and consequences for site specific SHA

    Science.gov (United States)

    Mascandola, Claudia; Massa, Marco; Barani, Simone; Lovati, Sara; Santulin, Marco

    2016-04-01

    This work deals with the problem of long period seismic site amplification that potentially might involve large and deep alluvial basins in case of strong earthquakes. In particular, it is here presented a case study in the Po Plain (Northern Italy), one of the most extended and deep sedimentary basin worldwide. Even if the studied area shows a low annul seismicity rate with rare strong events (Mw>6.0) and it is characterized by low to medium seismic hazard conditions, the seismic risk is significant for the high density of civil and strategic infrastructures (i.e. high degree of exposition) and the unfavourable geological conditions. The aim of this work is to provide general considerations about the seismic site response of the Po Plain, with particular attention on deep discontinuities (i.e. geological bedrock), in terms of potential low frequency amplification and their incidence on the PSHA. The current results were obtained through active and passive geophysical investigations performed near Castelleone, a site where a seismic station, which is part of the INGV (National Institute for Geophysics and Volcanology) Seismic National Network, is installed from 2009. In particular, the active analyses consisted in a MASW and a refraction survey, whereas the passive ones consisted in seismic ambient noise acquisitions with single stations and arrays of increasing aperture. The results in terms of noise HVSR indicate two main peaks, the first around 0.17 Hz and the second, as already stated in the recent literature, around 0.7 Hz. In order to correlate the amplified frequencies with the geological discontinuities, the array acquisitions were processed to obtain a shear waves velocity profile, computed with a joint inversion, considering the experimental dispersion curves and the HVSR results. The obtained velocity profile shows two main discontinuities: the shallower at ~165 m of depth, which can be correlated to the seismic bedrock (i.e. Vs > 800 m/) and the deeper

  4. Mid-Holocene palaeoflood events recorded at the Zhongqiao Neolithic cultural site in the Jianghan Plain, middle Yangtze River Valley, China

    Science.gov (United States)

    Wu, Li; Zhu, Cheng; Ma, Chunmei; Li, Feng; Meng, Huaping; Liu, Hui; Li, Linying; Wang, Xiaocui; Sun, Wei; Song, Yougui

    2017-10-01

    Palaeo-hydrological and archaeological investigations were carried out in the Jianghan Plain in the middle reaches of the Yangtze River. Based on a comparative analysis of modern flood sediments and multidisciplinary approaches such as AMS14C and archaeological dating, zircon micromorphology, grain size, magnetic susceptibility, and geochemistry, we identified palaeoflood sediments preserved at the Zhongqiao archaeological site. The results indicate that three palaeoflood events (i.e. 4800-4597, 4479-4367, and 4168-3850 cal. yr BP) occurred at the Zhongqiao Site. Comparisons of palaeoflood deposit layers at a number of Neolithic cultural sites show that two extraordinary palaeoflood events occurred in the Jianghan Plain during approximately 4900-4600 cal. yr BP (i.e.mid-late Qujialing cultural period) and 4100-3800 cal. yr BP (i.e. from late Shijiahe cultural period to the Xia Dynasty). Further analysis of the environmental context suggests that these flooding events might have been connected with great climate variability during approximately 5000-4500 cal. yr BP and at ca. 4000 cal. yr BP. These two palaeoflood events were closely related to the expansion of the Jianghan lakes driven by the climatic change, which in turn influenced the rise and fall of the Neolithic cultures in the middle reaches of the Yangtze River. Other evidence also suggests that the intensified discrepancy between social development and environmental change processes (especially the hydrological process) during the late Shijiahe cultural period might be the key factor causing the collapse of the Shijiahe Culture. The extraordinary floods related to the climatic anomaly at ca. 4000 cal. yr BP and political conflicts from internal or other cultural areas all accelerated the collapse of the Shijiahe Culture.

  5. Comparative distribution of cocaine- and amphetamine-regulated transcript (CART) in the hypothalamus of the capuchin monkey (Cebus apella) and the common marmoset (Callithrix jacchus).

    Science.gov (United States)

    Cavalcante, Judney Cley; Cândido, Paulo Laino; Sita, Luciane Valéria; do Nascimento, Expedito Silva; Cavalcante, Jeferson de Souza; de Oliveira Costa, Miriam Stela Maris; Bittencourt, Jackson Cioni; Elias, Carol Fuzeti

    2011-11-24

    Cocaine- and amphetamine-regulated transcript (CART) is widely distributed in the brain of many species. In the hypothalamus, CART neurotransmission has been implicated in diverse functions including energy balance, stress response, and temperature and endocrine regulation. Although some studies have been performed in primates, very little is known about the distribution of CART neurons in New World monkeys. New World monkeys are good models for systems neuroscience, as some species have evolved several behavioral and anatomical characteristics shared with humans, including diurnal and social habits, intense maternal care, complex manipulative abilities and well-developed frontal cortices. In the present study, we assessed the distribution of CART mRNA and peptide in the hypothalamus of the capuchin monkey (Cebus apella) and the common marmoset (Callithrix jacchus). We found that the distribution of hypothalamic CART neurons in these monkeys is similar to what has been described for rodents and humans, but some relevant differences were noticed. Only in capuchin monkeys CART neurons were observed in the suprachiasmatic and the intercalatus nuclei, whereas only in marmoset CART neurons were observed in the dorsal anterior nucleus. We also found that the only in marmoset displayed CART neurons in the periventricular preoptic nucleus and in an area seemingly comprising the premammillary nucleus. These hypothalamic sites are both well defined in rodents but poorly defined in humans. Our findings indicate that CART expression in hypothalamic neurons is conserved across species but the identified differences suggest that CART is also involved in the control of species-specific related functions.

  6. Getting started with OpenCart module development

    CERN Document Server

    Nepali, Rupak

    2013-01-01

    Written as a step-by-step guide, Getting Started with OpenCart Module Development will teach you all you need to know about OpenCart, from custom extensions to module development.This book is for developers who want to develop OpenCart extensions and for those who want to learn more about the code workflow of OpenCart. Basic knowledge of OpenCart would be an added advantage.

  7. Ground-water flow, geochemistry, and effects of agricultural practices on nitrogen transport at study sites in the Piedmont and Coastal Plain physiographic provinces, Patuxent River basin, Maryland

    Science.gov (United States)

    McFarland, Randolph E.

    1997-01-01

    In an effort to improve water quality in Chesapeake Bay, agricultural practices are being promoted that are intended to reduce contaminant transport to the Bay. The effects of agricultural practices on nitrogen transport were assessed at two 10-acre study sites in the Patuxent River basin, Maryland, during 1986-92. Nitrogen load was larger in ground water than in surface runoff at both sites. At the study site in the Piedmont Province, nitrogen load in ground water decreased from 12 to 6 (lb/acre)/yr (pound per acre per year) as corn under no-till cultivation was replaced by no-till soybeans, continuous alfalfa, and contoured strip crops alternated among corn, alfalfa, and soybeans. At the study site in the Coastal Plain Province, no-till soybeans resulted in a nitrogen load in ground water of 12.55 (lb/acre)/yr, whereas conventional-till soybeans resulted in a nitrogen load in ground water of 11.51 (lb/acre)/yr.

  8. Appetite regulation in Schizothorax prenanti by three CART genes.

    Science.gov (United States)

    Yuan, Dengyue; Wei, Rongbin; Wang, Tao; Wu, Yuanbing; Lin, Fangjun; Chen, Hu; Liu, Ju; Gao, Yundi; Zhou, Chaowei; Chen, Defang; Li, Zhiqiong

    2015-12-01

    In recent years, cocaine- and amphetamine-regulated transcript (CART) has received much attention as mediators of appetite regulation in mammals. However, the involvement of CART in the feeding behavior of teleosts has not been well understood. In this study, three distinct CARTs were cloned from the Schizothorax prenanti (S. prenanti). Real-time quantitative PCR were applied to characterize the tissue distribution and appetite regulatory effects of CARTs in S. prenanti. The S. prenanti CART-1, CART-2 and CART-3 full-length cDNA sequences were 597 bp, 694 bp and 749 bp in length, encoding the peptides of 125, 120 and 104 amino acid residues, respectively. All the S. prenanti CARTs consisted of three exons and two introns. Tissue distribution analysis showed that the high mRNA levels of S. prenanti CART-1 were observed in the telencephalon and eye, followed by the hypothalamus, myelencephalon, and mesencephalon. The S. prenanti CART-2 mRNA was mainly found in the mesencephalon, hypothalamus, telencephalon and myelencephalon. The S. prenanti CART-3 mRNA was widely distributed among the tissues, with the high levels in the hypothalamus and foregut. In the periprandial experiment, all three CARTs mRNA expressions in the hypothalamus were highly elevated after a meal, suggesting that CARTs are postprandial satiety signals. In the fasting experiment, all three CARTs mRNA expressions decreased after fasting and increased after refeeding, suggesting that CARTs might be involved in regulation of appetite in the S. prenanti.

  9. Cocaine- and amphetamine-regulated transcript (CART signaling within the paraventricular thalamus modulates cocaine-seeking behaviour.

    Directory of Open Access Journals (Sweden)

    Morgan H James

    Full Text Available BACKGROUND: Cocaine- and amphetamine-regulated transcript (CART has been demonstrated to play a role in regulating the rewarding and reinforcing effects of various drugs of abuse. A recent study demonstrated that i.c.v. administration of CART negatively modulates reinstatement of alcohol seeking, however, the site(s of action remains unclear. We investigated the paraventricular thalamus (PVT as a potential site of relapse-relevant CART signaling, as this region is known to receive dense innervation from CART-containing hypothalamic cells and to project to a number of regions known to be involved in mediating reinstatement, including the nucleus accumbens (NAC, medial prefrontal cortex (mPFC and basolateral amygdala (BLA. METHODOLOGY/PRINCIPAL FINDINGS: Male rats were trained to self-administer cocaine before being extinguished to a set criterion. One day following extinction, animals received intra-PVT infusions of saline, tetrodotoxin (TTX; 2.5 ng, CART (0.625 µg or 2.5 µg or no injection, followed by a cocaine prime (10 mg/kg, i.p.. Animals were then tested under extinction conditions for one hour. Treatment with either TTX or CART resulted in a significant attenuation of drug-seeking behaviour following cocaine-prime, with the 2.5 µg dose of CART having the greatest effect. This effect was specific to the PVT region, as misplaced injections of both TTX and CART resulted in responding that was identical to controls. CONCLUSIONS/SIGNIFICANCE: We show for the first time that CART signaling within the PVT acts to inhibit drug-primed reinstatement of cocaine seeking behaviour, presumably by negatively modulating PVT efferents that are important for drug seeking, including the NAC, mPFC and BLA. In this way, we identify a possible target for future pharmacological interventions designed to suppress drug seeking.

  10. Characteristics of pollutants and their correlation to meteorological conditions at a suburban site in the North China Plain

    Directory of Open Access Journals (Sweden)

    W. Y. Xu

    2011-03-01

    Full Text Available North China Plain (NCP is one of the most densely populated regions in China and has experienced enormous economic growth in the past decades. Its regional trace gas pollution has also become one of the top environmental concerns in China. Measurements of surface trace gases, including O3, NOx, SO2 and CO were carried out within the HaChi (Haze in China project at Wuqing Meteorology Station, located between 2 mega-cities (Beijing and Tianjin in the NCP, from 9 July 2009 to 21 January 2010. Detailed statistical analyses were made in order to provide information on the levels of the measured air pollutants and their characteristics. Gaseous air pollutant concentrations were also studied together with meteorological data and satellite data to help us better understand the causes of the observed variations in the trace gases during the field campaign. In comparison to measurements from other rural and background stations in the NCP, relatively higher concentrations were detected in Wuqing, presumably due to regional mixing and transport of pollutants. Local meteorology had deterministic impacts on air pollution levels, which have to be accounted for when evaluating other effects on pollutant concentrations. Trace gas concentrations showed strong dependence on wind, providing information on regional pollution characteristics. O3 mixing ratio also showed clear dependencies on temperature and relative humidity.

  11. CART peptide in the nucleus accumbens regulates psychostimulants: Correlations between psychostimulant and CART peptide effects.

    Science.gov (United States)

    Job, Martin O; Kuhar, Michael J

    2017-02-16

    In this study, we reexamined the effect of Cocaine-and-Amphetamine-Regulated-Transcript (CART) peptide on psychostimulant (PS)-induced locomotor activity (LMA) in individual rats. The Methods utilized were as previously published. The PS-induced LMA was defined as the distance traveled after PS administration (intraperitoneal), and the CART peptide effect was defined as the change in the PS-induced activity after bilateral intra-NAc administration of CART peptide. The experiments included both male and female Sprague-Dawley rats, and varying the CART peptide dose and the PS dose. While the average effect of CART peptide was to inhibit PS-induced LMA, the effect of CART peptide on individual PS-treated animals was not always inhibitory and sometimes even produced an increase or no change in PS-induced LMA. Upon further analysis, we observed a linear correlation, reported for the first time, between the magnitude of PS-induced LMA and the CART peptide effect. Because CART peptide inhibits PS-induced LMA when it is large, and increases PS-induced LMA when it is small, the peptide can be considered a homeostatic regulator of dopamine (DA)-induced LMA, which supports our earlier homeostatic hypothesis.

  12. Clear-Water Contraction Scour at Selected Bridge Sites in the Black Prairie Belt of the Coastal Plain in Alabama, 2006

    Science.gov (United States)

    Lee, K.G.; Hedgecock, T.S.

    2008-01-01

    The U.S. Geological Survey, in cooperation with the Alabama Department of Transportation, made observations of clear-water contraction scour at 25 bridge sites in the Black Prairie Belt of the Coastal Plain of Alabama. These bridge sites consisted of 54 hydraulic structures, of which 37 have measurable scour holes. Observed scour depths ranged from 1.4 to 10.4 feet. Theoretical clear-water contraction-scour depths were computed for each bridge and compared with observed scour. This comparison showed that theoretical scour depths, in general, exceeded the observed scour depths by about 475 percent. Variables determined to be important in developing scour in laboratory studies along with several other hydraulic variables were investigated to understand their influence within the Alabama field data. The strongest explanatory variables for clear-water contraction scour were channel-contraction ratio and velocity index. Envelope curves were developed relating both of these explanatory variables to observed scour. These envelope curves provide useful tools for assessing reasonable ranges of scour depth in the Black Prairie Belt of Alabama.

  13. Aquifer geochemistry at potential aquifer storage and recovery sites in coastal plain aquifers in the New York city area, USA

    Science.gov (United States)

    Brown, C.J.; Misut, P.E.

    2010-01-01

    The effects of injecting oxic water from the New York city (NYC) drinking-water supply and distribution system into a nearby anoxic coastal plain aquifer for later recovery during periods of water shortage (aquifer storage and recovery, or ASR) were simulated by a 3-dimensional, reactive-solute transport model. The Cretaceous aquifer system in the NYC area of New York and New Jersey, USA contains pyrite, goethite, locally occurring siderite, lignite, and locally varying amounts of dissolved Fe and salinity. Sediment from cores drilled on Staten Island and western Long Island had high extractable concentrations of Fe, Mn, and acid volatile sulfides (AVS) plus chromium-reducible sulfides (CRS) and low concentrations of As, Pb, Cd, Cr, Cu and U. Similarly, water samples from the Lloyd aquifer (Cretaceous) in western Long Island generally contained high concentrations of Fe and Mn and low concentrations of other trace elements such as As, Pb, Cd, Cr, Cu and U, all of which were below US Environmental Protection Agency (USEPA) and NY maximum contaminant levels (MCLs). In such aquifer settings, ASR operations can be complicated by the oxidative dissolution of pyrite, low pH, and high concentrations of dissolved Fe in extracted water.The simulated injection of buffered, oxic city water into a hypothetical ASR well increased the hydraulic head at the well, displaced the ambient groundwater, and formed a spheroid of injected water with lower concentrations of Fe, Mn and major ions in water surrounding the ASR well, than in ambient water. Both the dissolved O2 concentrations and the pH of water near the well generally increased in magnitude during the simulated 5-a injection phase. The resultant oxidation of Fe2+ and attendant precipitation of goethite during injection provided a substrate for sorption of dissolved Fe during the 8-a extraction phase. The baseline scenario with a low (0.001M) concentration of pyrite in aquifer sediments, indicated that nearly 190% more water

  14. The Mattassee Lake Sites: Archeological Investigations Along the Lower Santee River in the Coastal Plain of South Carolina.

    Science.gov (United States)

    1982-12-01

    340 .- q Fourteen taxa were identified: Woodland features at site 38BK246 yielded GRAMINEAE (Grass family), CYPERACEAE blackberry and dogwood. ( sedge ... sedge , pickerelweed, bayberry and Nyssa or Biplisia spp.), and grape seed (Widmer spp. (if this is tupelo, N. sylvatica). 1976a:36). The seeds were...with the swamp or swamp margin, including americana (poke), Rubus spp. (blackberry), sedge , pickerelweed, bayberry and possibly LEGUMICOSAE (Bean family

  15. Orchard spatial information extraction from SPOT-5 image based on CART model

    Science.gov (United States)

    Li, Deyi; Zhang, Shuwen

    2009-07-01

    Orchard is an important agricultural industry and typical land use type in Shandong peninsula of China. This article focused on the automatic information extraction of orchard using SPOT-5 image. After analyzing every object's spectrum, we proposed a CART model based on sub-region and hierarchy theory by exploring spectrum, texture and topography attributes. The whole area was divided into coastal plain region and hill region based on SRTM data and extracted respectively. The accuracy reached to 86.40%, which was much higher than supervised classification method.

  16. Plains Traveler

    Science.gov (United States)

    2006-01-01

    10 April 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a dust devil traveling across a plain west-southwest of Schiaparelli Crater, in far eastern Sinus Meridiani. The dust devil is casting a shadow toward the northeast, just south (below) of an egg-shaped crater. Location near: 6.4oS, 349.3oW Image width: 3 km (1.9 mi) Illumination from: lower left Season: Southern Summer

  17. Utopia Plain

    Science.gov (United States)

    2006-01-01

    5 March 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a dark-toned, cratered plain in southwest Utopia Planitia. Large, light-toned, windblown ripples reside on the floors of many of the depressions in the scene, including a long, linear, trough. Location near: 30.3oN, 255.3oW Image width: 3 km (1.9 mi) Illumination from: lower left Season: Northern Winter

  18. 21 CFR 868.6175 - Cardiopulmonary emergency cart.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Cardiopulmonary emergency cart. 868.6175 Section... (CONTINUED) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Miscellaneous § 868.6175 Cardiopulmonary emergency cart. (a) Identification. A cardiopulmonary emergency cart is a device intended to store and...

  19. Large-Eddy Simulation of Shallow Cumulus over Land: A Composite Case Based on ARM Long-Term Observations at Its Southern Great Plains Site

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yunyan [Lawrence Livermore National Laboratory, Livermore, California; Klein, Stephen A. [Lawrence Livermore National Laboratory, Livermore, California; Fan, Jiwen [Pacific Northwest National Laboratory, Richland, Washington; Chandra, Arunchandra S. [Division of Meteorology and Physical Oceanography, University of Miami, Miami, Florida; Kollias, Pavlos [School of Marine and Atmospheric Sciences, Stony Brook University, State University of New York, Stony Brook, New York; Xie, Shaocheng [Lawrence Livermore National Laboratory, Livermore, California; Tang, Shuaiqi [Lawrence Livermore National Laboratory, Livermore, California

    2017-10-01

    Based on long-term observations by the Atmospheric Radiation Measurement program at its Southern Great Plains site, a new composite case of continental shallow cumulus (ShCu) convection is constructed for large-eddy simulations (LES) and single-column models. The case represents a typical daytime non-precipitating ShCu whose formation and dissipation are driven by the local atmospheric conditions and land-surface forcing, and are not influenced by synoptic weather events. The case includes: early-morning initial profiles of temperature and moisture with a residual layer; diurnally-varying sensible and latent heat fluxes which represent a domain average over different land-surface types; simplified large-scale horizontal advective tendencies and subsidence; and horizontal winds with prevailing direction and average speed. Observed composite cloud statistics are provided for model evaluation. The observed diurnal cycle is well-reproduced by LES, however the cloud amount, liquid water path, and shortwave radiative effect are generally underestimated. LES are compared between simulations with an all-or-nothing bulk microphysics and a spectral bin microphysics. The latter shows improved agreement with observations in the total cloud cover and the amount of clouds with depths greater than 300 meters. When compared with radar retrievals of in-cloud air motion, LES produce comparable downdraft vertical velocities, but a larger updraft area, velocity and updraft mass flux. Both observation and LES show a significantly larger in-cloud downdraft fraction and downdraft mass flux than marine ShCu.

  20. Comment les jeunes gens utilisent les cartes

    Directory of Open Access Journals (Sweden)

    H. Sandford

    1990-09-01

    Full Text Available Des recherches sur l’utilisation des cartes dans les collèges et les lycées révèlent une hiérarchie de procédés qui met au jour des lacunes dans la formation au niveau secondaire.

  1. Chacun sa carte? Le nouveau Google Maps

    Directory of Open Access Journals (Sweden)

    Thierry Joliveau

    2013-08-01

    Full Text Available Google prépare une nouvelle version de Google Maps qu’il est possible de tester en avant-première. L’interface utilisateur est réaménagée pour une plus grande fluidité et une meilleure interactivité entre la carte et les photographies, avec une intégration optimisée des recherches d’itinéraires à la consultation. Mais la principale innovation mise en avant par la firme est plus radicale. Dans cette nouvelle version, la carte va s’adapter à l’utilisateur: «plus vous utilisez la carte plus elle devient utile», annonce Google. Le principe est simple. En fonction de vos recherches, des endroits que vous visitez, des lieux conseillés par vos amis sur les réseaux et des remarques que vous ajoutez, Google Maps apprendra à mieux cerner vos intérêts et vous proposera un contenu plus adapté. La carte est personnalisée et intègre les habitudes et les besoins de l’utilisateur.

  2. A Three-Year Study of Ichyoplankton in Coastal Plains Reaches of the Savannah River Site and its Tributaries

    Energy Technology Data Exchange (ETDEWEB)

    Martin, D.

    2007-03-05

    Altering flow regimes of rivers has large effects on native floras and faunas because native species are adapted to the natural flow regime, many species require lateral connectivity with floodplain habitat for feeding or spawning, and the change in regime often makes it possible for invasive species to replace natives (Bunn & Arthington 2002). Floodplain backwaters, both permanent and temporary, are nursery areas for age 0+ fish and stable isotope studies indicate that much of the productivity that supports fish larvae is autochthonous to these habitats (Herwig et al. 2004). Limiting access by fish to floodplain habitat for feeding, spawning and nursery habitat is one of the problems noted with dams that regulate flow in rivers and is considered to be important as an argument to remove dams and other flow regulating structures from rivers (Shuman 1995; Bednarek 2001). While there have been a number of studies in the literature about the use of floodplain habitat for fish reproduction (Copp 1989; Killgore & Baker 1996; Humphries, et al. 1999; Humphries and Lake 2000; Crain et al. 2004; King 2004) there have been only a few studies that examined this aspect of stream ecology in more than a cursory way. The study reported here was originally designed to determine whether the Department of Energy's (DOE) Savannah River Site was having a negative effect on fish reproduction in the Savannah River but its experimental design allowed examination of the interactions between the river, the floodplain and the tributaries entering the Savannah River across this floodplain. This study is larger in length of river covered than most in the literature and because of its landscape scale may be in important indicator of areas where further study is required.

  3. Multi-EM27/SUN Total Carbon Column Observing Network (TCCON) Comparison at the Southern Great Plains Site Field Campaign Report

    Energy Technology Data Exchange (ETDEWEB)

    Parker, H. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hedelius, J. [California Inst. of Technology (CalTech), Pasadena, CA (United States)

    2016-04-01

    During the summer of 2015, a field campaign took place to help characterize off-the-shelf portable solar-viewing Fourier Transform Spectrometer (FTS) instruments (EM27/SUN). These instruments retrieve greenhouse gas (GHG) abundances from direct solar spectra. A focus of this campaign was to test possible dependence on different atmospheric conditions. Along with the U.S. Department of Energy’s Atmospheric Radiation Measurement (ARM) Climate Research Facility Southern Great Plains (SGP) site in Oklahoma, experiments were conducted in Pasadena, California; Park Falls, Wisconsin; and the Armstrong Flight Research Center (AFRC), California. These locations are home to instruments in the Total Column Carbon Observing Network (TCCON). TCCON measurements were used as standards for the portable (EM27/SUN) measurements. Comparisons between the two types of instruments are crucial in the attempt to use the portable instruments to broaden the capabilities of GHG measurements for monitoring, reporting, and verification of carbon in the atmosphere. This campaign was aimed at testing the response of the portable FTS to different atmospheric conditions both local and regional. Measurements made at ARM SGP provided data in an agricultural environment with a relatively clean atmosphere with respect to pollution. Due to the homogeneity of the region surrounding Lamont, Oklahoma, portable FTS measurements were less effected by large changes in column GHG abundances from air mass movement between regions. These conditions aided in characterizing potential artificial solar zenith angle dependence of the retrievals. Data collected under atmospheric conditions at ARM SGP also provide for the analysis of cloud interference on solar spectra. In situ measurements were also made using a Picarro isotopic methane analyzer to determine surface-level in situ GHG concentrations and possible influences due to local agriculture and nearby towns. Data collected in this campaign have been presented

  4. Revisiting Plain Language.

    Science.gov (United States)

    Mazur, Beth

    2000-01-01

    Discusses the plain language movement and its origins. Reviews past and current resources related to plain language writing. Examines criticism of the movement while examining past and current plain language literature, with particular attention to the information design field. (SR)

  5. CART in the regulation of appetite and energy homeostasis.

    Science.gov (United States)

    Lau, Jackie; Herzog, Herbert

    2014-01-01

    The cocaine- and amphetamine-regulated transcript (CART) has been the subject of significant interest for over a decade. Work to decipher the detailed mechanism of CART function has been hampered by the lack of specific pharmacological tools like antagonists and the absence of a specific CART receptor(s). However, extensive research has been devoted to elucidate the role of the CART peptide and it is now evident that CART is a key neurotransmitter and hormone involved in the regulation of diverse biological processes, including food intake, maintenance of body weight, reward and addiction, stress response, psychostimulant effects and endocrine functions (Rogge et al., 2008; Subhedar et al., 2014). In this review, we focus on knowledge gained on CART's role in controlling appetite and energy homeostasis, and also address certain species differences between rodents and humans.

  6. CART in the regulation of appetite and energy homeostasis

    Science.gov (United States)

    Lau, Jackie; Herzog, Herbert

    2014-01-01

    The cocaine- and amphetamine-regulated transcript (CART) has been the subject of significant interest for over a decade. Work to decipher the detailed mechanism of CART function has been hampered by the lack of specific pharmacological tools like antagonists and the absence of a specific CART receptor(s). However, extensive research has been devoted to elucidate the role of the CART peptide and it is now evident that CART is a key neurotransmitter and hormone involved in the regulation of diverse biological processes, including food intake, maintenance of body weight, reward and addiction, stress response, psychostimulant effects and endocrine functions (Rogge et al., 2008; Subhedar et al., 2014). In this review, we focus on knowledge gained on CART's role in controlling appetite and energy homeostasis, and also address certain species differences between rodents and humans. PMID:25352770

  7. Quantifying the contribution of long-range transport to Particulate Matter (PM mass loadings at a suburban site in the North-Western Indo Gangetic Plain (IGP

    Directory of Open Access Journals (Sweden)

    H. Pawar

    2015-04-01

    Full Text Available Many sites in the densely populated Indo Gangetic Plain (IGP frequently exceed the national ambient air quality standard (NAAQS of 100 μg m−3 for 24 h average PM10 and 60 μg m−3 for 24 h average PM2.5 mass loadings, exposing residents to hazardous levels of PM throughout the year. We quantify the contribution of long range transport to elevated PM levels and the number of exceedance events through a back trajectory climatology analysis of air masses arriving at the IISER Mohali Atmospheric Chemistry facility (30.667° N, 76.729° E; 310 m a.m.s.l. for the period August 2011–June 2013. Air masses arriving at the receptor site were classified into 6 clusters, which represent synoptic scale air mass transport patterns and the average PM mass loadings and number of exceedance events associated with each air mass type were quantified for each season. Long range transport from the west leads to significant enhancements in the average coarse mode PM mass loadings during all seasons. The contribution of long range transport from the west and south west (Source region: Arabia, Thar desert, Middle East and Afghanistan to coarse mode PM varied between 9 and 57% of the total PM10−2.5 mass. Local pollution episodes (wind speed −1 contributed to enhanced coarse mode PM only during winter season. South easterly air masses (Source region: Eastern IGP were associated with significantly lower coarse mode PM mass loadings during all seasons. For fine mode PM too, transport from the west usually leads to increased mass loadings during all seasons. Local pollution episodes contributed to enhanced PM2.5 mass loadings during winter and summer season. South easterly air masses were associated with significantly lower PM2.5 mass loadings during all seasons. Using simultaneously measured gas phase tracers we demonstrate that most PM2.5 originated from combustion sources. The fraction of days in each season during which the PM mass loadings exceeded the

  8. Using CART to segment road images

    Science.gov (United States)

    Davies, Bob; Lienhart, Rainer

    2006-01-01

    The 2005 DARPA Grand Challenge is a 132 mile race through the desert with autonomous robotic vehicles. Lasers mounted on the car roof provide a map of the road up to 20 meters ahead of the car but the car needs to see further in order to go fast enough to win the race. Computer vision can extend that map of the road ahead but desert road is notoriously similar to the surrounding desert. The CART algorithm (Classification and Regression Trees) provided a machine learning boost to find road while at the same time measuring when that road could not be distinguished from surrounding desert.

  9. CART mRNA全CDS区序列的克隆与表达载体的构建%Cloning of the sequence of CDS region of pig CART mRNA and construction of the expression vector

    Institute of Scientific and Technical Information of China (English)

    李鹏飞; 李富禄; 于秀菊; 吕丽华

    2011-01-01

    选用猪为研究对象,以可卡因苯异丙胺调控转录肽(CART)作为影响猪繁殖机能的多肽,依据NCBI上登录的CARTmRNA序列设计3对特异性引物,用RT-PCR方法从下丘脑内扩增出CART mRNA的部分序列并进行序列分析;再根据扩增出的序列设计一对带酶切位点的特异性引物,用PCR方法扩增出含EcoR Ⅰ/HindⅢ酶切位点的CART mRNA的全编码序列(CDS)区序列.结果表明:猪下丘脑CART mRNA的CDS区全长367 bp,CART基因在下丘脑上有表达,并成功构建pEG-32a-CART原核表达载体.%Designing three pain specific primers based on the CART mRNA sequence included in NCBI GenBank, CART tnRNA sequences were amplified via RT-PCR from porcine hypothalamus tissue, and were analyzed. According to the amplified sequence, we designed a pair of expressing primers, amplified the whole coding sequence ( CDS) domain of CART including EcoR Ⅰ/Hind Ⅲ digestion sites. The results showed that; the length of CDS in porcine hypothalamus CART mRNA is 367 bp, CART gene can express in the hypothalamus, and it had successfully constructed prokaryotic expression vector of pEG-32a-CART.

  10. Southern Great Plains Safety Orientation

    Energy Technology Data Exchange (ETDEWEB)

    Schatz, John

    2014-05-01

    Welcome to the Atmospheric Radiation Measurement (ARM) Climate Research Facility (ARM) Southern Great Plains (SGP) site. This U.S. Department of Energy (DOE) site is managed by Argonne National Laboratory (ANL). It is very important that all visitors comply with all DOE and ANL safety requirements, as well as those of the Occupational Safety and Health Administration (OSHA), the National Fire Protection Association, and the U.S. Environmental Protection Agency, and with other requirements as applicable.

  11. The Retarding Force on a Fan-Cart Reversing Direction

    Science.gov (United States)

    Aurora, Tarlok S.; Brunner, Bernard J.

    2011-01-01

    In introductory physics, students learn that an object tossed upward has a constant downward acceleration while going up, at the highest point and while falling down. To demonstrate this concept, a self-propelled fan cart system is used on a frictionless track. A quick push is given to the fan cart and it is allowed to move away on a track under…

  12. CART in the brain of vertebrates: circuits, functions and evolution.

    Science.gov (United States)

    Subhedar, Nishikant K; Nakhate, Kartik T; Upadhya, Manoj A; Kokare, Dadasaheb M

    2014-04-01

    Cocaine- and amphetamine-regulated transcript peptide (CART) with its wide distribution in the brain of mammals has been the focus of considerable research in recent years. Last two decades have witnessed a steady rise in the information on the genes that encode this neuropeptide and regulation of its transcription and translation. CART is highly enriched in the hypothalamic nuclei and its relevance to energy homeostasis and neuroendocrine control has been understood in great details. However, the occurrence of this peptide in a range of diverse circuitries for sensory, motor, vegetative, limbic and higher cortical areas has been confounding. Evidence that CART peptide may have role in addiction, pain, reward, learning and memory, cognition, sleep, reproduction and development, modulation of behavior and regulation of autonomic nervous system are accumulating, but an integration has been missing. A steady stream of papers has been pointing at the therapeutic potentials of CART. The current review is an attempt at piecing together the fragments of available information, and seeks meaning out of the CART elements in their anatomical niche. We try to put together the CART containing neuronal circuitries that have been conclusively demonstrated as well as those which have been proposed, but need confirmation. With a view to finding out the evolutionary antecedents, we visit the CART systems in sub-mammalian vertebrates and seek the answer why the system is shaped the way it is. We enquire into the conservation of the CART system and appreciate its functional diversity across the phyla.

  13. Um corpo de cartógrafo

    Directory of Open Access Journals (Sweden)

    Flavia Liberman

    2015-03-01

    Full Text Available A cartografia tem sido discutida no Brasil como um método em pesquisa que pressupõe uma reversão metodológica na qual o caminhar na pesquisa antecede a definição de metas a serem alcançadas. Este texto busca contribuir para as discussões sobre a formação do cartógrafo, considerando que, para se realizar uma pesquisa na perspectiva cartográfica, é preciso um corpo que mobilize algumas qualidades, como: atenção, presença, disponibilidade, sensibilidade, entre outras. Ao aproximar nossa experiência teórico-prática do pensamento de autores ligados à filosofia da diferença e das ideias de Keleman e Favre sobre temáticas que envolvem o corpo, buscou-se sistematizar algumas guias para a construção de um corpo de cartógrafo, que pudessem servir de orientação na pesquisa, na prática profissional e nos processos de ensino-aprendizagem. Ao longo do texto, procuramos pensar a construção de dispositivos que promovam encontros plasmados por afetos e acontecimentos.

  14. Final report for the project "Improving the understanding of surface-atmosphere radiative interactions by mapping surface reflectance over the ARM CART site" (award DE-FG02-02ER63351)

    Energy Technology Data Exchange (ETDEWEB)

    Alexander P. Trishchenko; Yi Luo; Konstantin V. Khlopenkov, William M. Park; Zhanqing Li; Maureen Cribb

    2008-11-28

    Surface spectral reflectance (albedo) is a fundamental variable affecting the transfer of solar radiation and the Earth’s climate. It determines the proportion of solar energy absorbed by the surface and reflected back to the atmosphere. The International Panel on Climate Change (IPCC) identified surface albedo among key factors influencing climate radiative forcing. Accurate knowledge of surface reflective properties is important for advancing weather forecasting and climate change impact studies. It is also important for determining radiative impact and acceptable levels of greenhouse gases in the atmosphere, which makes this work strongly linked to major scientific objectives of the Climate Change Research Division (CCRD) and Atmospheric Radiation Measurement (ARM) Program. Most significant accomplishments of eth project are listed below. I) Surface albedo/BRDF datasets from 1995 to the end of 2004 have been produced. They were made available to the ARM community and other interested users through the CCRS public ftp site ftp://ftp.ccrs.nrcan.gc.ca/ad/CCRS_ARM/ and ARM IOP data archive under “PI data Trishchenko”. II) Surface albedo properties over the ARM SGP area have been described for 10-year period. Comparison with ECMWF data product showed some deficiencies in the ECMWF surface scheme, such as missing some seasonal variability and no dependence on sky-conditions which biases surface energy budget and has some influence of the diurnal cycle of upward radiation and atmospheric absorption. III) Four surface albedo Intensive Observation Period (IOP) Field Campaigns have been conducted for every season (August, 2002, May 2003, February 2004 and October 2004). Data have been prepared, documented and transferred to ARM IOP archive. Nine peer-reviewed journal papers and 26 conference papers have been published.

  15. CART in the Regulation of Appetite and Energy Homeostasis

    Directory of Open Access Journals (Sweden)

    Jackie eLau

    2014-10-01

    Full Text Available The cocaine- and amphetamine-regulated transcript (CART has been the subject of significant interest for over a decade. Work to decipher the detailed mechanism of CART function has been hampered by the lack of specific pharmacological tools like antagonists and the absence of a specific CART receptor(s. However, extensive research has been devoted to elucidate the role of the CART peptide and it is now evident that CART is a key neurotransmitter and hormone involved in the regulation of diverse biological processes, including food intake, maintenance of body weight, reward and addiction, stress response, psychostimulant effects and endocrine functions1,2. In this review, we focus on knowledge gained on CART’s role in controlling appetite and energy homeostasis, and also address certain species differences between rodents and humans.

  16. Establishing guidelines for CAR-T cells: challenges and considerations.

    Science.gov (United States)

    Wang, Wei; Qin, Di-Yuan; Zhang, Bing-Lan; Wei, Wei; Wang, Yong-Sheng; Wei, Yu-Quan

    2016-04-01

    T cells, genetically modified by chimeric antigen receptors (CAR-T), are endowed with specificity to a desired antigen and are cytotoxic to cells expressing the targeted antigen. CAR-T-based cancer immunotherapy is a promising therapy for curing hematological malignancy, such as acute lymphoid leukemia, and is promising for extending their efficacy to defeat solid tumors. To date, dozens of different CAR-T cells have been evaluated in clinical trials to treat tumors; this necessitates the establishment of guidelines for the production and application of CAR-T cells. However, it is challenging to standardize CAR-T cancer therapy because it involves a combination of gene therapy and cell therapy. In this review, we compare the existing guidelines for CAR-T cells and discuss the challenges and considerations for establishing guidance for CAR-T-based cancer immunotherapy.

  17. Evaluation of the New York City Green Carts program

    Directory of Open Access Journals (Sweden)

    Shannon M Farley

    2015-12-01

    Full Text Available Access to fresh fruits and vegetables is a concern, particularly among low-income populations. Mobile vending is one strategy to expand produce availability and access to increase consumption. In 2008, New York City launched a mobile vending initiative, Green Carts. We report on the evaluation. Three waves of cross-sectional observational surveys of produce availability, variety, and quality were conducted during the summers of 2008, 2009, and 2011 in a stratified random sample of stores and carts comparing establishments in Green Cart neighborhoods (n = 13 with comparison neighborhoods (n = 3. Bivariate analyses for availability, variety, and quality comparing Green Cart and comparison neighborhoods were presented across years, and logistic and negative binomial regressions were used to test whether fruit and vegetable availability, variety, and quality increased in Green Cart compared with comparison neighborhoods, adjusting for clustering and neighborhood demographics. Establishments selling fruits and vegetables in Green Cart neighborhoods increased between 2008 and 2011 (50% to 69%, p <0.0001; there was no comparable increase in comparison neighborhoods. Establishments selling more than 10 fruits and vegetables types increased from 31% to 38% (p = 0.0414 in Green Cart neighborhoods; there was no change in comparison neighborhoods. Produce quality was high among comparison establishments, with 95% and 94% meeting the quality threshold in 2008 and 2011, while declining in Green Cart neighborhood establishments from 96% to 88% (p < 0.0001. Sustained produce availability was found in Green Cart neighborhoods between 2008–2011. Green Carts are one strategy contributing to improving produce access among New Yorkers.

  18. New concept for CTO recanalization using controlled antegrade and retrograde subintimal tracking: the CART technique.

    Science.gov (United States)

    Surmely, Jean-François; Tsuchikane, Etsuo; Katoh, Osamu; Nishida, Yasunori; Nakayama, Mutsuo; Nakamura, Shigeru; Oida, Akitsugu; Hattori, Eijiro; Suzuki, Takahiko

    2006-07-01

    To demonstrate the safety and feasibility of a new concept for CTO recanalization using a controlled antegrade and retrograde subintimal tracking technique (CART technique). A successful percutaneous recanalization of chronic coronary occlusions results in improved survival, as well as enhanced left ventricular function, reduction in angina, and improved exercise tolerance. However, successful recanalization of CTOs is still not optimal, and needs further improvements. Ten patients with a CTO underwent the CART procedure. This technique combines the simultaneous use of the antegrade and retrograde approaches. A subintimal dissection is created antegradely and retrogradely, which allows the operator to limit the extension of the subintimal dissection in the CTO portion. A retrograde approach means that the occlusion site is approached in a retrograde fashion through the best collateral channel from any other patent coronary artery. The occlusion site was located in the RCA in 9 patients, and in the LAD in 1 patient. CTO duration varied from 7 to 84 months. Vessel recanalization was achieved in all patients. In all cases, the subintimal dissection was limited to the CTO region. No complications occurred in the collateral channel used for the retrograde approach. There were no in-hospital major adverse cardiac events. The CART technique is feasible, safe, and has a high success rate.

  19. Microinjection of CART (cocaine- and amphetamine-regulated transcript) peptide into the nucleus accumbens inhibits the cocaine-induced upregulation of dopamine receptors and locomotor sensitization.

    Science.gov (United States)

    Peng, Qinghua; Sun, Xi; Liu, Ziyong; Yang, Jianghua; Oh, Ki-Wan; Hu, Zhenzhen

    2014-09-01

    Repeated exposure to addictive drugs enhances dopamine receptor (DR) signaling and the ultimate phosphorylation of the cyclic adenosine 5'-monophosphate (cAMP)-response element-binding protein (CREB)-regulated cocaine- and amphetamine-regulated transcript (CART) expression in the nucleus accumbens (NAcc). These effects are known to contribute to the expression of behavioral sensitization. CART peptides are neuropeptides that modulate drug reward and reinforcement. The present experiments investigated the effects of CART 55-102 microinjection into the NAcc on (1) the phosphorylation of CREB, (2) cAMP/protein kinase A (PKA) signaling and (3) extracellular signal-regulated kinase (ERK) phosphorylated kinase signaling. Here, we show that repeated microinjections into the NAcc of CART 55-102 peptides (1.0 or 2.5μg, 0.5μl/side) attenuates cocaine-induced enhancements of D1R, D2R and D3R phosphorylation in this sites. Furthermore, the microinjection of CART 55-102 followed by repeated injections of cocaine (15mg/kg) dose-dependently blocked the enhancement of cAMP levels, PKA activity and pERK and pCREB levels on the fifth day of cocaine administration. The cocaine-induced locomotor activity and behavioral sensitization in rats were also inhibited by the 5-day-microinjection of CART peptides. These results suggest that the phosphorylation of CREB by cocaine in the NAcc was blocked by the CART 55-102 peptide via the inhibition of D1R and D2R stimulation, D3R phosphorylation, cAMP/PKA signaling and ERK phosphorylated kinase signaling. These effects may have played a compensatory inhibitory role in the behavioral sensitization of rats that received microinjections of CART 55-102.

  20. The Astrographic Catalogue and the Carte du Ciel

    Science.gov (United States)

    Jaschek, C.

    1985-11-01

    Answers to a circular letter concerning the Astrographic Catalogue and the Carte du Ciel from Alger (A. Ghezloun), Catania (C. Blanco), Cordoba (G. Carranza), Greenwich (P. J. Andrews), Paris (J. Delhaye), Sydney (A. E. Vaughan), Toulouse (R. Nadal).

  1. Classification and Regression Trees(CART) Theory and Applications

    OpenAIRE

    Timofeev, Roman

    2004-01-01

    This master thesis is devoted to Classification and Regression Trees (CART). CART is classification method which uses historical data to construct decision trees. Depending on available information about the dataset, classification tree or regression tree can be constructed. Constructed tree can be then used for classification of new observations. The first part of the thesis describes fundamental principles of tree construction, different splitting algorithms and pruning procedures. Seco...

  2. Potential Antidepressant Role of Neurotransmitter CART: Implications for Mental Disorders

    Directory of Open Access Journals (Sweden)

    Peizhong Mao

    2011-01-01

    Full Text Available Depression is one of the most prevalent and debilitating public health concerns. Although no single cause of depression has been identified, it appears that interaction among genetic, epigenetic, biochemical, environmental, and psychosocial factors may explain its etiology. Further, only a fraction of depressed patients show full remission while using current antidepressants. Therefore, identifying common pathways of the disorder and using that knowledge to develop more effective pharmacological treatments are two primary targets of research in this field. Brain-enriched neurotransmitter CART (cocaine- and amphetamine-regulated transcript has multiple functions related to emotions. It is a potential neurotrophic factor and is involved in the regulation of hypothalamic-pituitary-adrenal axis and stress response as well as in energy homeostasis. CART is also highly expressed in limbic system, which is considered to have an important role in regulating mood. Notably, adolescents carrying a missense mutation in the CART gene exhibit increased depression and anxiety. Hence, CART peptide may be a novel promising antidepressant agent. In this paper, we summarize recent progress in depression and CART. In particular, we emphasize a new antidepressant function for CART.

  3. Failure and Redemption of Multifilter Rotating Shadowband Radiometer (MFRSR)/Normal Incidence Multifilter Radiometer (NIMFR) Cloud Screening: Contrasting Algorithm Performance at Atmospheric Radiation Measurement (ARM) North Slope of Alaska (NSA) and Southern Great Plains (SGP) Sites

    Energy Technology Data Exchange (ETDEWEB)

    Kassianov, Evgueni I.; Flynn, Connor J.; Koontz, Annette S.; Sivaraman, Chitra; Barnard, James C.

    2013-09-11

    Well-known cloud-screening algorithms, which are designed to remove cloud-contaminated aerosol optical depths (AOD) from AOD measurements, have shown great performance at many middle-to-low latitude sites around the world. However, they may occasionally fail under challenging observational conditions, such as when the sun is low (near the horizon) or when optically thin clouds with small spatial inhomogeneity occur. Such conditions have been observed quite frequently at the high-latitude Atmospheric Radiation Measurement (ARM) North Slope of Alaska (NSA) sites. A slightly modified cloud-screening version of the standard algorithm is proposed here with a focus on the ARM-supported Multifilter Rotating Shadowband Radiometer (MFRSR) and Normal Incidence Multifilter Radiometer (NIMFR) data. The modified version uses approximately the same techniques as the standard algorithm, but it additionally examines the magnitude of the slant-path line of sight transmittance and eliminates points when the observed magnitude is below a specified threshold. Substantial improvement of the multi-year (1999-2012) aerosol product (AOD and its Angstrom exponent) is shown for the NSA sites when the modified version is applied. Moreover, this version reproduces the AOD product at the ARM Southern Great Plains (SGP) site, which was originally generated by the standard cloud-screening algorithms. The proposed minor modification is easy to implement and its application to existing and future cloud-screening algorithms can be particularly beneficial for challenging observational conditions.

  4. The Role of Surface Energy Exchange for Simulating Wind Inflow: An Evaluation of Multiple Land Surface Models in WRF for the Southern Great Plains Site Field Campaign Report

    Energy Technology Data Exchange (ETDEWEB)

    Wharton, Sonia [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Simpson, Matthew [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Osuna, Jessica [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Newman, Jennifer [National Renewable Energy Lab. (NREL), Golden, CO (United States); Biraud, Sebastien [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2016-05-01

    The Weather Research and Forecasting (WRF) model is used to investigate choice of land surface model (LSM) on the near-surface wind profile, including heights reached by multi-megawatt wind turbines. Simulations of wind profiles and surface energy fluxes were made using five LSMs of varying degrees of sophistication in dealing with soil-plant-atmosphere feedbacks for the U.S. Department of Energy (DOE) Atmospheric Radiation Measurement (ARM) Climate Research Facility’s Southern Great Plains (SGP) Central Facility in Oklahoma. Surface-flux and wind-profile measurements were available for validation. The WRF model was run for three two-week periods during which varying canopy and meteorological conditions existed. The LSMs predicted a wide range of energy-flux and wind-shear magnitudes even during the cool autumn period when we expected less variability. Simulations of energy fluxes varied in accuracy by model sophistication, whereby LSMs with very simple or no soil-plant-atmosphere feedbacks were the least accurate; however, the most complex models did not consistently produce more accurate results. Errors in wind shear also were sensitive to LSM choice and were partially related to the accuracy of energy flux data. The variability of LSM performance was relatively high, suggesting that LSM representation of energy fluxes in the WRF model remains a significant source of uncertainty for simulating wind turbine inflow conditions.

  5. Evaluating the Quality and Accuracy of TanDEM-X Digital Elevation Models at Archaeological Sites in the Cilician Plain, Turkey

    Directory of Open Access Journals (Sweden)

    Stefan Erasmi

    2014-10-01

    Full Text Available Satellite remote sensing provides a powerful instrument for mapping and monitoring traces of historical settlements and infrastructure, not only in distant areas and crisis regions. It helps archaeologists to embed their findings from field surveys into the broader context of the landscape. With the start of the TanDEM-X mission, spatially explicit 3D-information is available to researchers at an unprecedented resolution worldwide. We examined different experimental TanDEM-X digital elevation models (DEM that were processed from two different imaging modes (Stripmap/High Resolution Spotlight using the operational alternating bistatic acquisition mode. The quality and accuracy of the experimental DEM products was compared to other available DEM products and a high precision archaeological field survey. The results indicate the potential of TanDEM-X Stripmap (SM data for mapping surface elements at regional scale. For the alluvial plain of Cilicia, a suspected palaeochannel could be reconstructed. At the local scale, DEM products from TanDEM-X High Resolution Spotlight (HS mode were processed at 2 m spatial resolution using a merge of two monostatic/bistatic interferograms. The absolute and relative vertical accuracy of the outcome meet the specification of high resolution elevation data (HRE standards from the National System for Geospatial Intelligence (NSG at the HRE20 level.

  6. Aux cartes citoyens. La démocratie par les cartes

    Directory of Open Access Journals (Sweden)

    Anne Chapuis

    2000-11-01

    Full Text Available Les cartes, images puissantes rendant visible et compréhensibles des informations nombreuses et complexes, ont une vocation naturelle à servir de support aux débats sur l'aménagement du territoire et aux actions de développement, et en cela être un des outils privilégiés de la démocratie. Plusieurs expériences au sein de collectivités territoriales en France et au sein d'organismes de développement en Inde nous ont démontré que l'utilisation de cartes et matrices pour l'aide à la décision est le plus souvent jugée dangereuse. Bien construites elles sont révélatrices des déséquilibres spatiaux, des enjeux de pouvoir et bien entendu de la corruption. Nous présentons quelques unes de ces expériences avec en arrière plan les enjeux de la démocratie et de la Transparence tant vantées et si peu pratiquées.

  7. Potential groundwater sampling sites for installation of a well network for long-term monitoring of agricultural chemicals in the High Plains Aquifer, Colorado

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — These data are in support of report DS 456 (Arnold and others, 2009). This dataset includes 90 potential groundwater sampling sites randomly generated using...

  8. Variation of Stable Carbon and Nitrogen Isotopic Composition of PM10 at Urban Sites of Indo Gangetic Plain (IGP) of India.

    Science.gov (United States)

    Sharma, S K; Mandal, T K; Shenoy, D M; Bardhan, Pratirupa; Srivastava, Manoj K; Chatterjee, A; Saxena, Mohit; Saraswati; Singh, B P; Ghosh, S K

    2015-11-01

    This paper presents the variation of elemental concentrations of total carbon (TC), total nitrogen (TN) and isotopic ratios of δ13C and δ15N along with δ13OC and OC of PM10 mass over Delhi, Varanasi and Kolkata of the Indo Gangetic Plain (IGP), India. For Delhi, the average concentrations of TC and TN of PM10 were 53.0±33.6 and 14.9±10.8 µg m(-3), whereas δ13C and δ15N of PM10 were -25.5±0.5 and 9.6±2.8‰, respectively. For Varanasi, the average values of δ13C and δ15N of PM10 were -25.4±0.8 and 6.8±2.4‰, respectively. For Kolkata, TC and TN values for PM10 ranged from 9.1-98.2 to 1.4-25.9 µg m(-3), respectively with average values of 32.6±24.9 and 9.3±8.2 µg m(-3), respectively. The average concentrations of δ13C and δ15N were -26.0±0.4 and 7.4±2.7‰, respectively over Kolkata with ranges of -26.6 to -24.9‰ and 2.8±11.5‰, respectively. The isotopic analysis revealed that biomass burning, vehicular emission and secondary inorganic aerosols were likely sources of PM10 mass over IGP, India.

  9. [Analysis of Single Particle Aging and Mixing State at an Agriculture Site (Quzhou) in the North China Plain in Summer Using a Single Particle Aerosol Mass Spectrometer].

    Science.gov (United States)

    Huang, Zi-long; Zeng, Li-mm; Dong, I-Iua-Bin; Li, Mei; Zhu, Tong

    2016-04-15

    To characterize the size distribution and chemical ompsitins f abiet prtices t a agicuturesit intheNorh o Chinese Plain, a single particle aerosol mass spectrometer (SPAMS) was deployed from June 30 to July 8, 2013. A total of 230,152 particles in the size range of 0.2-2.0 pm were chemically analyzed with both positive and negative ion spectra. The results revealed that aerosol could he classified into eight dominant groups, including elemental carbon (EC, 55.5%), organic carbon (OC, 10.7%), alkalis (Na-K, 17.4%), other metals (1.7%), Fe-rich (6.3%), Pb-rich (3.1%), dust (4.8%), and other (0.8%). The observed eight types of particles contained secondary components such as 46NO2-, 62NO3-, 96SO3-, 96SO4-, 97HSO4-, showing that they probably went through different aging processes. The analysis of particle size distribution showed that 700-800 nm was the peak value of all particles, and that dust and Fe particles were mainly in the coarse size range. EC particles subtype group research revealed EC particles tended to be aging with the above mentioned secondary ions and eventually led to a particle type conversion from EC to the less aging ECN and the more serious aging ECS, the diurnal variation of which was obviously negatively correlated, and there was a possibility of forming OC/EC mixture with the adsorption of secondary organic matter on EC surface.

  10. Atmospheric Line of Site Experiment (ALOSE) Final Campaign Summary

    Energy Technology Data Exchange (ETDEWEB)

    Smith, W. [Atmospheric Radiation Measurement (ARM) Climate Research Facility, Washington, DC (United States); Green, S. [Atmospheric Radiation Measurement (ARM) Climate Research Facility, Washington, DC (United States); Howard, M. [Atmospheric Radiation Measurement (ARM) Climate Research Facility, Washington, DC (United States); Yesalusky, M. [Atmospheric Radiation Measurement (ARM) Climate Research Facility, Washington, DC (United States); Modlin, N. [Atmospheric Radiation Measurement (ARM) Climate Research Facility, Washington, DC (United States)

    2016-03-01

    The Atmospheric Line of Site Experiment (ALOSE) was a project to produce best-estimate atmospheric state measurements at the: 1. DOE Atmospheric Radiation Measurement (ARM) Clouds and Radiation Test-bed (CART) site located in Lamont, Oklahoma (11–14 December 2012) 2. Poker Flat Alaska Research Range (PFRR) located in Poker Flat, Alaska (19–26 February 2013) 3. DOE ARM CART site located in Lamont, Oklahoma (24–28 April 2013) 4. DOE ARM CART site located in Lamont, Oklahoma (9–15 July 2013) 5. DOE ARM Tropical Western Pacific (TWP) site located in Darwin, Australia (27 September–3 October 2013).

  11. Radical chemistry at a rural site (Wangdu) in the North China Plain: observation and model calculations of OH, HO2 and RO2 radicals

    Science.gov (United States)

    Tan, Zhaofeng; Fuchs, Hendrik; Lu, Keding; Hofzumahaus, Andreas; Bohn, Birger; Broch, Sebastian; Dong, Huabin; Gomm, Sebastian; Häseler, Rolf; He, Lingyan; Holland, Frank; Li, Xin; Liu, Ying; Lu, Sihua; Rohrer, Franz; Shao, Min; Wang, Baolin; Wang, Ming; Wu, Yusheng; Zeng, Limin; Zhang, Yinsong; Wahner, Andreas; Zhang, Yuanhang

    2017-01-01

    A comprehensive field campaign was carried out in summer 2014 in Wangdu, located in the North China Plain. A month of continuous OH, HO2 and RO2 measurements was achieved. Observations of radicals by the laser-induced fluorescence (LIF) technique revealed daily maximum concentrations between (5-15) × 106 cm-3, (3-14) × 108 cm-3 and (3-15) × 108 cm-3 for OH, HO2 and RO2, respectively. Measured OH reactivities (inverse OH lifetime) were 10 to 20 s-1 during daytime. The chemical box model RACM 2, including the Leuven isoprene mechanism (LIM), was used to interpret the observed radical concentrations. As in previous field campaigns in China, modeled and measured OH concentrations agree for NO mixing ratios higher than 1 ppbv, but systematic discrepancies are observed in the afternoon for NO mixing ratios of less than 300 pptv (the model-measurement ratio is between 1.4 and 2 in this case). If additional OH recycling equivalent to 100 pptv NO is assumed, the model is capable of reproducing the observed OH, HO2 and RO2 concentrations for conditions of high volatile organic compound (VOC) and low NOx concentrations. For HO2, good agreement is found between modeled and observed concentrations during day and night. In the case of RO2, the agreement between model calculations and measurements is good in the late afternoon when NO concentrations are below 0.3 ppbv. A significant model underprediction of RO2 by a factor of 3 to 5 is found in the morning at NO concentrations higher than 1 ppbv, which can be explained by a missing RO2 source of 2 ppbv h-1. As a consequence, the model underpredicts the photochemical net ozone production by 20 ppbv per day, which is a significant portion of the daily integrated ozone production (110 ppbv) derived from the measured HO2 and RO2. The additional RO2 production from the photolysis of ClNO2 and missing reactivity can explain about 10 % and 20 % of the discrepancy, respectively. The underprediction of the photochemical ozone

  12. Molecular composition of organic aerosol over an agricultural site in North China Plain: Contribution of biogenic sources to PM2.5

    Science.gov (United States)

    Li, Xingru; Liu, Yusi; Li, Dong; Wang, Guoan; Bai, Yu; Diao, Heling; Shen, Rongrong; Hu, Bo; Xin, Jinyuan; Liu, Zirui; Wang, Yuesi; Guo, Xueqing; Wang, Lili

    2017-09-01

    Sugars and biogenic secondary organic aerosols (BSOAs) are substantial components of particulate organic matter, which affects regional and global air quality and climate. Fine particulate matter (PM2.5) samples were collected from 20 June to 30 July 2015 on a diurnal/nocturnal cycle in Yucheng, China in the North China Plain. The PM2.5 samples were analyzed for sugars and SOA tracers derived from biogenic volatile organic compounds (BVOCs) and other compounds, such as water soluble ions, element carbon (EC), organic carbon (OC) and water soluble organic carbon (WSOC). The quantified organic components accounted for 4.7% and 0.4% of the OC and PM2.5, respectively. SOA tracer concentrations were weakly higher during the day (101.6 ± 61.7 ng m-3) than at night (90.2 ± 41.5 ng m-3)(t = 0.610, P > 0.05), whereas sugar showed higher concentrations at night (227.0 ± 196.9 ng m-3) than during the day (177.9 ± 145.4 ng m-3)(t = -1.329, P > 0.05). Anhydro sugar (mannosan, galactosan, and levoglucosan) were the main components of the measured sugars and accounted for 58.5% and 75.6% of the daytime and nighttime measurements. The levoglucosan/mannosan ratios were 20.2 ± 12.9 and 17.6 ± 9.1 for the daytime and nighttime samples, respectively, indicating that crop residues, herbaceous plants and hardwood were the dominant types of biomass burned in the Yucheng region. Isoprene SOA tracers exhibited the highest levels among the measured SOA tracers, followed by α-pinene SOA tracers. The concentration of BSOC estimated using the tracer method was 3.9-1817.5 ng C m-3 and accounted for 0.1-26.0% of the OC. A clear negative correlation (r = 0.53) between isoprene-derived SOA and in-situ pH demonstrated that acid-catalyzed heterogeneous reactions can significantly enhance SOA mass. In addition, isoprene-derived SOA increased with the relative humidity (RH) when the RH was lower than 50%, whereas it decreased when the RH was higher than 50%.

  13. Distribution of atmospheric reactive nitrogen at two sites of different socio- economic characteristics in IndoGangetic Plain(IGP) region, India.

    Science.gov (United States)

    Singh, S.; Sharma, A.; Kulshrestha, U. C.

    2015-12-01

    In India, most of the human population lives in rural areas. People depends on agriculture products to meet the demand of food supply. In order to get higher yield of agriculture and food product, increased practice of fertilizer application has added extra burden of nutrients especially, the reactive nitrogen (Nr) species viz NH3 and NOx. Growing energy demands has resulted in increased emissions of NOx from coal combustion in thermal power plant and the petroleum combustion in transport sector. In addition, biomass burning in traditional cooking and heating has become significant source of NH3 and NOx in Indian region. Significance of the study lies in the fact that increasing Nr emissions have adverse impact on human health, plant, soil and water bodies directly and to see the effect, knowledge of emission and deposition for Nr at different sites. Hence, the selection of the sites for present study was done very carefully. Delhi city and Mai village were selected to represent typical characteristics of high and low socioeconomic region respectively. Delhi is the capital of India, known for higher income group urban cluster where rural site having agricultural dominance has its importance in Indian scenario because still in India our primary source of income is agriculture. Atmospheric abundance of two major gaseous inorganic (Nr) species i.e NH3 and NO2 has been measured for one year, on monthly basis. Average concentrations of NH3 at urban and rural site have been recorded as 40.4 ±16.8 and 51.57 ±22.8 μg/m3 respectively. The average concentrations of NO2 have been recorded as 24.4 ±13.5 and 18.8 ± 12.6 μg/m3 at urban & rural site respectively. Study, also presents seasonal and diurnal variations of gaseous reactive nitrogen species at urban & rural sites to observe the contribution of different the sources of atmospheric Nr. Dynamics of Nr at both sites will be discussed in details at the conference.

  14. Object Transportation by Two Mobile Robots with Hand Carts.

    Science.gov (United States)

    Sakuyama, Takuya; Figueroa Heredia, Jorge David; Ogata, Taiki; Hara, Tatsunori; Ota, Jun

    2014-01-01

    This paper proposes a methodology by which two small mobile robots can grasp, lift, and transport large objects using hand carts. The specific problems involve generating robot actions and determining the hand cart positions to achieve the stable loading of objects onto the carts. These problems are solved using nonlinear optimization, and we propose an algorithm for generating robot actions. The proposed method was verified through simulations and experiments using actual devices in a real environment. The proposed method could reduce the number of robots required to transport large objects with 50-60%. In addition, we demonstrated the efficacy of this task in real environments where errors occur in robot sensing and movement.

  15. Simulation and Test of a Fuel Cell Hybrid Golf Cart

    Directory of Open Access Journals (Sweden)

    Jingming Liang

    2014-01-01

    Full Text Available This paper establishes the simulation model of fuel cell hybrid golf cart (FCHGC, which applies the non-GUI mode of the Advanced Vehicle Simulator (ADVISOR and the genetic algorithm (GA to optimize it. Simulation of the objective function is composed of fuel consumption and vehicle dynamic performance; the variables are the fuel cell stack power sizes and the battery numbers. By means of simulation, the optimal parameters of vehicle power unit, fuel cell stack, and battery pack are worked out. On this basis, GUI mode of ADVISOR is used to select the rated power of vehicle motor. In line with simulation parameters, an electrical golf cart is refitted by adding a 2 kW hydrogen air proton exchange membrane fuel cell (PEMFC stack system and test the FCHGC. The result shows that the simulation data is effective but it needs improving compared with that of the real cart test.

  16. Les voix/voies de la carte

    Directory of Open Access Journals (Sweden)

    Louise Bénat-Tachot

    2012-01-01

    Full Text Available La confection du padrón real par les experts de la Casa de la Contratación de Séville dans la première moitié du XVIe siècle, a été un enjeu majeur non seulement pour établir la nouvelle configuration globale du monde mais aussi pour légitimer les entreprises d’expansion des nations ibériques en affirmant la maîtrise de la navigation. Dans quelle mesure la rédaction des premières chroniques des Indes est-elle liée à cette activité cartographique d’état qui lui est contemporaine ? Les liens épistémologiques, rhétoriques et politiques qui lient ces deux productions seront étudiés à partir de la carte universelle de Diego de Ribeiro et de deux chroniques : celle de Gonzalo Fernández de Oviedo et celle de Francisco López de Gómara.La confección del padrón real por los expertos de la Casa de la Contratación de Sevilla durante la primera mitad del siglo XVI, fue de mayor trascendencia no sólo por cartografiar la nueva configuración del mundo sino también porque legitimaba la empresa de expansión de las naciones ibéricas así como para afirmaba su dominio de la navegación. ¿ En qué medida se vincula la redacción de las primeras crónicas de Indias con esta actividad de estado cartográfica contemporánea ? Los vínculos epistemológicos, retóricos y políticos que unen estas dos producciones serán analizados a partir de la carta universal de Diego de Ribeiro y de las dos crónicas primitivas de Indias : la de Gonzalo Fernández de Oviedo y la de Francisco López de Gómara.

  17. Reduced CSF CART in dementia with Lewy bodies

    DEFF Research Database (Denmark)

    Schultz, Kristofer; Wiehager, Sara; Nilsson, Karin

    2009-01-01

    Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia after Alzheimer's disease (AD). The underlying neurobiological mechanism of DLB is not fully understood and no generally accepted biomarkers are yet available for the diagnosis of DLB. In a recent MRI study......, DLB patients displayed hypothalamic atrophy whereas this region was not affected in AD patients. Cocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed selectively in neurons in the hypothalamus. Here, we found that CSF CART levels were significantly reduced by 30% in DLB...

  18. 江汉平原石家河谭家岭遗址新石器时代环境考古%Environmental archaeology of the Tanjialing Neolithic Site in the Shijiahe Ancient City, the Jianghan Plain of Central China

    Institute of Scientific and Technical Information of China (English)

    吴立; 朱诚; 李冰; 李枫; 孙伟; 王晓翠; 刘辉; 孟华平; 孙珏

    2016-01-01

    Background, aim, and scope The middle Yangtze River basin is a developing and lfourishing area of the Neolithic cultures, as revealed by abundant archaeological sites in the Jianghan Plain. The Shijiahe Culture is representative of an advanced stage in the Neolithic Age, and archaeological remains reflect the features of native culture in the Jianghan Plain. The Shijiahe Culture fully flourished in its early and middle stages, but it deteriorated around 4.2 ka BP. Some topics of the cause of this cultural deterioration such as the war, disaster, climatic events, southward migration, and abandonment of the ancient city are still under debate. Also, no systematic analysis was conducted throughout the method of archaeological stratigraphy. Therefore, the Tanjialing Neolithic Site during the Shijiahe cultural period provides a good opportunity and material to examine the relationship between anthropogenic impact and environmental dynamics by palynomorph-TOC-TN-δ13Corg-magnetic susceptibility analysis, owing to its well chronological control, rich organic sediment, and unique archaeological ifndings. This study is highly necessary to better understand interaction between human and nature in this special historical period. Materials and methods The Shijiahe ancient city is located in the northwest of Shihe Town, Tianmen City, Hubei Province, and geographically lies in the north-central Jianghan Plain. The terrain is higher in the northwest, and the elevation is 33—40 m above sea level. The Tanjialing Neolithic Site is situated in the center of Shijiahe ancient city. An archaeological sedimentary proifle, in the south wall of T0620 from the site, was examined for pollen, TOC, TN, δ13Corg and magnetic susceptibility. The proifle is 330 cm in thickness and divided into 9 lithological horizons. 28 samples were collected in the 9th layer, 22 samples in the cultural layers for palynological analysis, and 97 samples for TOC, TN,δ13Corg and magnetic susceptibility analysis

  19. Art on a Cart: A National Mixed Methods Investigation of Elementary Art Teacher Experiences and Perceptions

    Science.gov (United States)

    Lung, Heidi K.

    2013-01-01

    This study investigated the practice of elementary art teachers who utilize carts for the delivery of art lessons; to understand how the art on a cart practice influences art educators' approaches to curriculum development and instruction; and to identify challenges, benefits, and best practices. The practice of art on a cart is defined as the…

  20. 32 CFR 636.29 - Go-carts, minibikes, and all terrain vehicles (ATV's).

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Go-carts, minibikes, and all terrain vehicles... (SPECIFIC INSTALLATIONS) Fort Stewart, Georgia § 636.29 Go-carts, minibikes, and all terrain vehicles (ATV's). (a) Operators of “go-carts,” “minibikes,” and ATV's 16 years of age or older, must comply with...

  1. Iridoid glycoside content ofEuphydryas anicia (Lepidoptera: Nymphalidae) and its major hostplant,Besseya plantaginea (Scrophulariaceae), at a high plains colorado site.

    Science.gov (United States)

    L'empereur, K M; Stermitz, F R

    1990-01-01

    The checkerspot butterfly,Euphydryas anicia, utilizes mainlyBesseya plantaginea and only occasionallyCastilleja integra as a larval hostplant at Michigan Hill, a few kilometers from a site whereC. integra is used by over 90% of the butterflies. TheB. plantaginea leaves that are consumed contain 9-22% iridoid glycosides, composed mainly of catalpol and catalpol esters, while larvae from the same plants contain 6-18% iridoids, mainly catalpol and no esters. Field-collected adult butterflies contain 0.5-4.3% iridoids. Laboratory-reared adults secrete iridoids in the meconium upon eclosion and retain similar amounts. The adult and meconium iridoid content is considerably lower than in the larvae, and metabolism in the pupal stage may be occurring.

  2. The Plains of Venus

    Science.gov (United States)

    Sharpton, V. L.

    2013-12-01

    Volcanic plains units of various types comprise at least 80% of the surface of Venus. Though devoid of topographic splendor and, therefore often overlooked, these plains units house a spectacular array of volcanic, tectonic, and impact features. Here I propose that the plains hold the keys to understanding the resurfacing history of Venus and resolving the global stratigraphy debate. The quasi-random distribution of impact craters and the small number that have been conspicuously modified from the outside by plains-forming volcanism have led some to propose that Venus was catastrophically resurfaced around 725×375 Ma with little volcanism since. Challenges, however, hinge on interpretations of certain morphological characteristics of impact craters: For instance, Venusian impact craters exhibit either radar dark (smooth) floor deposits or bright, blocky floors. Bright floor craters (BFC) are typically 100-400 m deeper than dark floor craters (DFC). Furthermore, all 58 impact craters with ephemeral bright ejecta rays and/or distal parabolic ejecta patterns have bright floor deposits. This suggests that BFCs are younger, on average, than DFCs. These observations suggest that DFCs could be partially filled with lava during plains emplacement and, therefore, are not strictly younger than the plains units as widely held. Because the DFC group comprises ~80% of the total crater population on Venus the recalculated emplacement age of the plains would be ~145 Ma if DFCs are indeed volcanically modified during plains formation. Improved image and topographic data are required to measure stratigraphic and morphometric relationships and resolve this issue. Plains units are also home to an abundant and diverse set of volcanic features including steep-sided domes, shield fields, isolated volcanoes, collapse features and lava channels, some of which extend for 1000s of kilometers. The inferred viscosity range of plains-forming lavas, therefore, is immense, ranging from the

  3. Controllability of a planar inverted pendulum on a cart

    CERN Document Server

    Caiado, M Isabel

    2012-01-01

    Using tools and techniques from geometric control theory, namely Hermann-Nagano theorem, we prove controllability result for a mechanical system consisting of a planar double inverted pendulum fixed to a wheeled cart that can move linearly along a horizontal track.

  4. TEST OF AN ANIMAL DRAWN FIELD IMPLEMENT CART

    Directory of Open Access Journals (Sweden)

    Paolo Spugnoli

    2008-06-01

    Full Text Available The field performance of a horse-drawn hitch cart equipped with a PTO system powered by the two cart ground wheels have been investigated. For this purpose field tests on clay and turf soil, with varying ballast and PTO torque, have been carried out pulling the cart by a tractor. Preliminary tests were aimed at assessing the traction capability of horse breed. These tests showed that the mean draught force given by two of these horses was 173daN, average working speed was about 1m*s-1, resulting a mean draught power developed by each horse of about 0.86kW. The PTO cart system performance has shown that the torque has not exceeded 2.4daN*m, maximum draught or PTO power was 1.15kW, rotation speed just higher than 400min-1, with mean efficiency of about 50%. These values are consistent with horse performance and small haymaking, fertilizing, seeding and chemical application machine requirements.

  5. Smart Shopping Carts: How Real-Time Feedback Influences Spending

    NARCIS (Netherlands)

    Ittersum, van K.; Wansink, B.; Pennings, J.M.E.; Sheehan, D.

    2013-01-01

    Although interest in smart shopping carts is increasing, both retailers and consumer groups have concerns about how real-time spending feedback will influence shopping behavior. Building on budgeting and spending theories, the authors conduct three lab and grocery store experiments that robustly sho

  6. West Valley transfer cart control system design description

    Energy Technology Data Exchange (ETDEWEB)

    Bradley, E.C.; Crutcher, R.I.; Halliwell, J.W.; Hileman, M.S.; Moore, M.R.; Nodine, R.N.; Ruppel, F.R.; Vandermolen, R.I.

    1993-01-01

    Detail design of the control system for the West Valley Nuclear Services Vitrification Facility transfer cart has been completed by Oak Ridge National Laboratory. This report documents the requirements and describes the detail design of that equipment and control software. Copies of significant design documents including analysis and testing reports and design drawings are included in the Appendixes.

  7. Smart shopping carts : How real-time feedback influences spending

    NARCIS (Netherlands)

    van Ittersum, Koert; Wansink, B.; Pennings, J.M.E.; Sheehan, D.

    2013-01-01

    Although interest in smart shopping carts is increasing, both retailers and consumer groups have concerns about how real-time spending feedback will influence shopping behavior. Building on budgeting and spending theories, the authors conduct three lab and grocery store experiments that robustly sho

  8. Smart Shopping Carts: How Real-Time Feedback Influences Spending

    NARCIS (Netherlands)

    Ittersum, van K.; Wansink, B.; Pennings, J.M.E.; Sheehan, D.

    2013-01-01

    Although interest in smart shopping carts is increasing, both retailers and consumer groups have concerns about how real-time spending feedback will influence shopping behavior. Building on budgeting and spending theories, the authors conduct three lab and grocery store experiments that robustly sho

  9. Smart shopping carts : How real-time feedback influences spending

    NARCIS (Netherlands)

    van Ittersum, Koert; Wansink, B.; Pennings, J.M.E.; Sheehan, D.

    2013-01-01

    Although interest in smart shopping carts is increasing, both retailers and consumer groups have concerns about how real-time spending feedback will influence shopping behavior. Building on budgeting and spending theories, the authors conduct three lab and grocery store experiments that robustly sho

  10. Smart shopping carts : How real-time feedback influences spending

    NARCIS (Netherlands)

    van Ittersum, Koert; Wansink, B.; Pennings, J.M.E.; Sheehan, D.

    2013-01-01

    Although interest in smart shopping carts is increasing, both retailers and consumer groups have concerns about how real-time spending feedback will influence shopping behavior. Building on budgeting and spending theories, the authors conduct three lab and grocery store experiments that robustly

  11. Design and Construction of a Multimedia Technology Cart.

    Science.gov (United States)

    Hofstetter, Fred T.; And Others

    1993-01-01

    Describes a mobile classroom presentation cart for multimedia technology that was designed and constructed at the University of Delaware's Instructional Technology Center. Design goals are discussed; the physical layout is explained; equipment choices are described, including computer, audio system, and projection system; and future development is…

  12. Smart Shopping Carts: How Real-Time Feedback Influences Spending

    NARCIS (Netherlands)

    Ittersum, van K.; Wansink, B.; Pennings, J.M.E.; Sheehan, D.

    2013-01-01

    Although interest in smart shopping carts is increasing, both retailers and consumer groups have concerns about how real-time spending feedback will influence shopping behavior. Building on budgeting and spending theories, the authors conduct three lab and grocery store experiments that robustly

  13. La géographie de Jules Verne et ses cartes dans L’île mystérieuse

    Directory of Open Access Journals (Sweden)

    Jacky Fontanabona

    2010-05-01

    Full Text Available Destinés à la jeunesse, les Voyages extraordinaires ont une vocation récréative mais aussi éducative. Romancier, Jules Verne veut aussi contribuer à la diffusion d'une géographie de son temps, descriptive, encyclopédique, de plain-pied dans une réalité constituée de «faits avérés». Dans L’île mystérieuse, il subvertit cette dernière règle en narrant la colonisation d’un territoire fictif par des Robinsons. Articulant carte, images et texte littéraire, l'édition illustrée devient alors un système d’expression qui joue du diptyque véracité/véridicité pour inventer une chimère géographique.

  14. Modeling and Simulation of a Simple Cart with Low-Impact Casters

    Directory of Open Access Journals (Sweden)

    Tagami Masaharu

    2016-01-01

    Full Text Available Low-impact casters are of great importance in realizing low-crash and anti-vibration carts for a range of purposes. Here the principle of center of percussion is efficiently applied to a caster in order to suppress the transfer of crash forces to the cart from the caster. Excellent performance of this force suppression has been confirmed previously by both simulation and experiments in a single-caster cart. However, carts in real-life applications usually require four sets of casters. In this context, a mathematical model of a cart with four sets of low-impact casters was formulated. In this paper, the modeling a four-caster cart, and simulations for the cart passing over a bump are discussed.

  15. RAMAN LIDAR PROFILING OF WATER VAPOR AND AEROSOLS OVER THE ARM SGP SITE.

    Energy Technology Data Exchange (ETDEWEB)

    FERRARE,R.A.

    2000-01-09

    We have developed and implemented automated algorithms to retrieve profiles of water vapor mixing ratio, aerosol backscattering, and aerosol extinction from Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) Raman Lidar data acquired during both daytime and nighttime operations. This Raman lidar system is unique in that it is turnkey, automated system designed for unattended, around-the-clock profiling of water vapor and aerosols (Goldsmith et al., 1998). These Raman lidar profiles are important for determining the clear-sky radiative flux, as well as for validating the retrieval algorithms associated with satellite sensors. Accurate, high spatial and temporal resolution profiles of water vapor are also required for assimilation into mesoscale models to improve weather forecasts. We have also developed and implemented routines to simultaneously retrieve profiles of relative humidity. These routines utilize the water vapor mixing ratio profiles derived from the Raman lidar measurements together with temperature profiles derived from a physical retrieval algorithm that uses data from a collocated Atmospheric Emitted Radiance Interferometer (AERI) and the Geostationary Operational Environmental Satellite (GOES) (Feltz et al., 1998; Turner et al., 1999). These aerosol and water vapor profiles (Raman lidar) and temperature profiles (AERI+GOES) have been combined into a single product that takes advantage of both active and passive remote sensors to characterize the clear sky atmospheric state above the CART site.

  16. Raman lidar profiling of water vapor and aerosols over the ARM SGP Site

    Energy Technology Data Exchange (ETDEWEB)

    Ferrare, R.A.

    2000-01-09

    The authors have developed and implemented automated algorithms to retrieve profiles of water vapor mixing ratio, aerosol backscattering, and aerosol extinction from Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) Raman Lidar data acquired during both daytime and nighttime operations. The Raman lidar sytem is unique in that it is turnkey, automated system designed for unattended, around-the-clock profiling of water vapor and aerosols. These Raman lidar profiles are important for determining the clear-sky radiative flux, as well as for validating the retrieval algorithms associated with satellite sensors. Accurate, high spatial and temporal resolution profiles of water vapor are also required for assimilation into mesoscale models to improve weather forecasts. The authors have also developed and implemented routines to simultaneously retrieve profiles of relative humidity. These routines utilize the water vapor mixing ratio profiles derived from the Raman lidar measurements together with temperature profiles derived from a physical retrieval algorithm that uses data from a collocated Atmospheric Emitted Radiance Interferometer (AERI) and the Geostationary Operational Environmental Satellite (GOES). These aerosol and water vapor profiles (Raman lidar) and temperature profiles (AERI+GOES) have been combined into a single product that takes advantage of both active and passive remote sensors to characterize the clear sky atmospheric state above the CART site.

  17. Source apportionment and risk assessment of PM1 bound trace metals collected during foggy and non-foggy episodes at a representative site in the Indo-Gangetic plain.

    Science.gov (United States)

    Singh, Dharmendra Kumar; Gupta, Tarun

    2016-04-15

    The concentration, spatial distribution and source of 13-PM1 bound trace metals (Fe, Cu, Mn, Cr, Zn, Cd, Ni, K, Mg, Na, Ca, Pb and V) and adverse health effects of 5-PM1 bound trace metals (Mn, Zn, Ni, Cr and Cd) collected during foggy and non-foggy episodes are presented. Twenty-four samples from each period (foggy and non-foggy episodes) were collected from Kanpur, a typical densely populated city and the most polluted representative site in the Indo-Gangetic plain of India, and were analyzed for carcinogenic (Ni, Cr and Cd) and non-carcinogenic metals (Mn and Zn). The average mass concentration of PM1 during foggy and non-foggy episodes was found to be 160.16±37.70 and 132.87±27.97μg/m(3). Source identification via principle component analysis suggested that vehicular emission and anthropogenic, industrial and crustal dust were the dominant sources in this region. During both episodes the decreasing order of hazard quotient (Hq) for adult and children was as Mn>Cr>Cd>Ni>Zn. In a non-foggy episode the hazardous index (Hi) values of these 5 trace metals were found to be ~3.5 times higher than a foggy episode's exposed population, respectively. In a foggy episode, due to the exposure to total carcinogenic trace metals (Ni, Cr and Cd) present in the ambient air, 95% probability total incremental lifetime cancer risks (TIlcR) were ~687 cancer cases and ~402 cancer cases per million in the adult population and children population respectively. These cancer cases were ~1.6 times higher than a non-foggy episode's exposed population. Copyright © 2016 Elsevier B.V. All rights reserved.

  18. Application of CART Algorithm in Blood Donors Classification

    Directory of Open Access Journals (Sweden)

    T. Santhanam

    2010-01-01

    Full Text Available Problem statement: This study used data mining modeling techniques to examine the blood donor classification. The availability of blood in blood banks is a critical and important aspect in a healthcare system. Blood banks (in the developing countries context are typically based on a healthy person voluntarily donating blood and is used for transfusions or made into medications. The ability to identify regular blood donors will enable blood banks and voluntary organizations to plan systematically for organizing blood donation camps in an effective manner. Approach: Identify the blood donation behavior using the classification algorithms of data mining. The analysis had been carried out using a standard blood transfusion dataset and using the CART decision tree algorithm implemented in Weka. Results: Numerical experimental results on the UCI ML blood transfusion data with the enhancements helped to identify donor classification. Conclusion: The CART derived model along with the extended definition for identifying regular voluntary donors provided a good classification accuracy based model.

  19. Méthodologie de Conception de Cartes Rapides Workshop

    CERN Document Server

    2003-01-01

    - Problématique de développement de carte rapide pour l'expérience LHCb(transparents) - Solution basée sur le flot Cadence PSD14.2 de conception de circuits imprimés(CI) rapides (transparents) - Nouveau partage des taches entre l'ingénieur concepteur et le professionnel développeur de CI (transparents) - Démonstration du flot à partir d'un exemple concret pour l'expérience LHCb (Démo 1h min) - Conclusion : Essentiellement pour lancer une discussion sur l'impact de ce nouveau flot de conception Cadence sur la méthode de développement de cartes à l'IN2P3.

  20. Using hospital pharmacy technicians to check unit dose carts.

    Science.gov (United States)

    Spooner, S H; Emerson, P K

    1994-05-01

    This study was undertaken to evaluate the accuracy of technicians checking unit dose carts as compared with pharmacists checking unit dose carts. The final (after check) fill in both arms of the study was evaluated for accuracy on the same five criteria: 1) correct drug, 2) correct dose, 3) correct dosage form, 4) correct quantity, and 5) expiration date. In the technician arm, 7571 doses were checked with 10 errors, giving a 99.76% (1 error in 420) accuracy. In the pharmacist arm of the study, 3116 doses were checked with 34 total errors, giving a 98.91% (1 error in 92) accuracy. The results of this study indicate that technicians would have as high if not a higher accuracy rate than pharmacists. Using pharmacy technicians in this role should continue the same level of care by maintaining a high accuracy in medication dispensing and provide greater economic benefit to the organization by using technical rather than professional personnel.

  1. Zero-Spring-Rate Mechanism/Air Suspension Cart

    Science.gov (United States)

    Woodard, Stanley E.; Cooley, Victor M.

    1991-01-01

    Compact mechanism suspends articulating flexible structures with minimal constraints. Zero-spring-rate mechanism (ZSRM) air suspension cart used to suspend flexible, "mass-critical" articles like lightweight spacecraft undergoing such large motions as slewing, translation, and telescoping/retraction. Suspends flexible article undergoing large rigid-body motion concurrent with vibratory motion, with minimal interaction between suspended article and suspending hardware. Adaptive to active control, which reduces undesirable effects caused by friction, nonlinearity, and mass coupling. Practical for most suspension applications.

  2. Mountain-Plains Curriculum.

    Science.gov (United States)

    Mountain-Plains Education and Economic Development Program, Inc., Glasgow AFB, MT.

    The document lists the Mountain-Plains curriculum by job title (where applicable), including support courses. The curriculum areas covered are mathematics skills, communication skills, office education, lodging services, food services, marketing and distribution, welding support, automotive, small engines, career guidance, World of Work, health…

  3. Redesigning of Shopping Cart for Cost Reduction Using DFMA

    Directory of Open Access Journals (Sweden)

    Naiju C. D.

    2017-01-01

    Full Text Available Product Design is a way of creating new designs for various products to be sold by a business to customers. It is very efficient as certain new designs and ideas can lead to products with less cost. The two methodologies of design for manufacture and assembly (DFMA include design for manufacture (DFM which is concentrated on reducing the number of redundant parts for the ease of manufacturing and also design for assembly (DFA which is concentrated on reducing the assembly time of the parts included in the design of the product. It also helps to reduce the inefficiency and waste in the product design. This paper includes a case study of manufacture and assembly costs estimation of a shopping cart which is widely used in supermarkets, department stores all around the world. The main aim of this paper is to reduce the overall manufacturing cost of the shopping cart. The CAD model of the different parts of the shopping cart was generated using solid works and then analysed using the DFMA software. The outcomes were studied and the re-design is done. The final assembly cost of the re-designed product was compared to that of the existing design and the results are discussed.

  4. Distribution and chemical coding patterns of cocaine- and amphetamine-regulated transcript-like immunoreactive (CART-LI) neurons in the enteric nervous system of the porcine stomach cardia.

    Science.gov (United States)

    Rękawek, W; Sobiech, P; Gonkowski, S; Żarczyńska, K; Snarska, A; Waśniewski, T; Wojtkiewicz, J

    2015-01-01

    The aim of this study was to determine the presence of cocaine- and amphetamine-regulated transcript-like immunoreactive (CART-LI) neurons and co-localisation of CART with vesicular acetylcholine transporter (VAChT), neuronal nitric oxide synthase (n-NOS), vasoactive intestinal polypeptide (VIP), substance P (SP) and leu-enkephalin (LENK) in the enteric nervous system of the porcine gastric cardia by using a double-labelling immunofluorescence technique. CART-LI neurons were observed in the myenteric plexus (18.2±2.6%). A dense network of CART-LI nerve fibers was mainly observed in the muscular layer. CART showed co-localization mainly with VAChT, n-NOS, VIP and to a lesser degree with LENK and SP. Distribution of CART and its co-localization with other neurotransmitters suggest that this peptide plays an important role in gastric motility in the pig.

  5. Immunohistochemical distribution of cocaine- and amphetamine-regulated transcript peptide - like immunoreactive (CART-LI) nerve fibers and various degree of co-localization with other neuronal factors in the circular muscle layer of human descending colon.

    Science.gov (United States)

    Gonkowski, Sławomir; Kamińska, Barbara; Landowski, Piotr; Całka, Jarosław

    2013-07-01

    Cocaine- and amphetamine-regulated transcript peptide (CART) is a neuromediator and/or neuromodulator in nerve structures within the gastrointestinal tract, but knowledge about its distribution, functions and co-localisation with other neuronal factors, especially in humans, is very scarce. During the present investigation the distribution and immunohistochemical reaction (IR) of CART - like immunoreactive (CART-LI) nerve fibers in the circular muscle layer of human descending colon were studied. Fragments of human colon were processed for double labelling immunofluorescence using a mixture of anti-CART antibodies with antibodies against vesicular acetylocholine transporter (VAChT), vasoactive intestinal polypeptide (VIP), pituitary adenylate cyclase - activating peptide (PACAP), substance P (SP), galanin (GAL) and nitric oxide synthase (NOS). Thick CART-LI nerve fibers formed a very dense meshwork within the colonic circular muscle layer in all patients studied. The highest number of CART - positive nerves also contained VAChT and/or VIP. A slightly lower level of co-localisation was observed in the case of CART and PACAP or CART and NOS. Only single nerve fibers were concurrently immunoreactive to CART and SP or CART and GAL. The present study reports for the first time a detailed description of the IR of CART-LI nerve fibers in the circular muscle layer within adult human descending colon.

  6. Differential expression of CART in feeding and reward circuits in binge eating rat model.

    Science.gov (United States)

    Bharne, Ashish P; Borkar, Chandrashekhar D; Subhedar, Nishikant K; Kokare, Dadasaheb M

    2015-09-15

    Binge eating (BE) disrupts feeding and subverts reward mechanism. Since cocaine- and amphetamine-regulated transcript peptide (CART) mediates satiety as well as reward, its role in BE justifies investigation. To induce BE, rats were provided restricted access to high fat sweet palatable diet (HFSPD) for a period of 4 weeks. Immunoreactivity profile of the CART elements, and accompanying neuroplastic changes were studied in satiety- and reward-regulating brain nuclei. Further, we investigated the effects of CART, CART-antibody or rimonabant on the intake of normal chow or HFSPD. Rats fed on HFSPD showed development of BE-like phenotype as reflected by significant consumption of HFSPD in short time frame, suggestive of dysregulated satiety mechanisms. At the mid-point during BE, CART-immunoreactivity was significantly increased in hypothalamic arcuate (ARC), lateral (LH), nucleus accumbens shell (AcbSh) and paraventricular nucleus of thalamus (PVT). However, for next 22-h post-binge time-period, the animals showed no interest in food, and low CART expression. Pre-binge treatment with rimonabant, a drug recommended for the treatment of BE, produced anorexia, increased CART expression in ARC and LH, but not in AcbSh and PVT. Higher dose of CART was required to produce anorexia in binged rats. While neuronal tracing studies confirmed CART fiber connectivity from ARC and LH to AcbSh, increase in CART and synaptophysin immunostaining in this pathway in BE rats suggested strengthening of the CART connectivity. We conclude that CART bearing ARC-LH-PVT-AcbSh reward circuit may override the satiety signaling in ARC-PVN pathway in BE rats.

  7. Nicotine regulates cocaine-amphetamine-Regulated Transcript (Cart) in the mesocorticolimbic system.

    Science.gov (United States)

    Kaya, Egemen; Gozen, Oguz; Ugur, Muzeyyen; Koylu, Ersin O; Kanit, Lutfiye; Balkan, Burcu

    2016-07-01

    Cocaine-and-Amphetamine Regulated Transcript (CART) mRNA and peptides are intensely expressed in the brain regions comprising mesocorticolimbic system. Studies suggest that CART peptides may have a role in the regulation of reward circuitry. The present study aimed to examine the effect of nicotine on CART expression in the mesocorticolimbic system. Three different doses of nicotine (0.2, 0.4, 0.6 mg/kg free base) were injected subcutaneously for 5 days, and on day 6, rats were decapitated following a challenge dose. CART mRNA and peptide levels in medial prefrontal cortex (mPFC), nucleus accumbens (NAc), dorsal striatum (DST), amygdala (AMG), lateral hypothalamic area (LHA), and ventral tegmental area (VTA) were measured by quantitative real-time PCR (qPCR) and Western Blot analysis, respectively. In the mPFC, 0.4 and 0.6 mg/kg nicotine, decreased CART peptide levels whereas there was no effect on CART mRNA levels. In the VTA, a down-regulation of CART peptide expression was observed with 0.2 and 0.6 mg/kg nicotine. Conversely, 0.4 and 0.6 mg/kg nicotine increased CART mRNA levels in the AMG without affecting the CART peptide expression. Nicotine did not regulate CART mRNA or CART peptide expression in the NAc, DST, and LHA. We conclude that nicotine regulates CART expression in the mesocorticolimbic system and this regulation may play an important role in nicotine reward. Synapse 70:283-292, 2016. © 2016 Wiley Periodicals, Inc.

  8. CART treatment improves memory and synaptic structure in APP/PS1 mice.

    Science.gov (United States)

    Jin, Jia-li; Liou, Anthony K F; Shi, Yejie; Yin, Kai-lin; Chen, Ling; Li, Ling-ling; Zhu, Xiao-lei; Qian, Lai; Yang, Rong; Chen, Jun; Xu, Yun

    2015-05-11

    Major characteristics of Alzheimer's disease (AD) include deposits of β-amyloid (Aβ) peptide in the brain, loss of synapses, and cognitive dysfunction. Cocaine- and amphetamine-regulated transcript (CART) has recently been reported to attenuate Aβ-induced toxicity. In this study, CART localization in APP/PS1 mice was characterized and the protective effects of exogenous CART treatment were examined. Compared to age-matched wild type mice, 8-month-old APP/PS1 mice had significantly greater CART immunoreactivity in the hippocampus and cortex. A strikingly similar pattern of Aβ plaque-associated CART immunoreactivity was observed in the cortex of AD cases. Treatment of APP/PS1 mice with exogenous CART ameliorated memory deficits; this effect was associated with improvements in synaptic ultrastructure and long-term potentiation, but not a reduction of the Aβ plaques. Exogenous CART treatment in APP/PS1 mice prevented depolarization of the mitochondrial membrane and stimulated mitochondrial complex I and II activities, resulting in an increase in ATP levels. CART treatment of APP/PS1 mice also reduced reactive oxygen species and 4-hydroxynonenal, and mitigated oxidative DNA damage. In summary, CART treatment reduced multiple neuropathological measures and improved memory in APP/PS1 mice, and may therefore be a promising and novel therapy for AD.

  9. Reduced ethanol consumption and preference in cocaine- and amphetamine-regulated transcript (CART) knockout mice.

    Science.gov (United States)

    Salinas, Armando G; Nguyen, Chinh T Q; Ahmadi-Tehrani, Dara; Morrisett, Richard A

    2014-03-01

    Cocaine- and amphetamine-regulated transcript (CART) is a neuropeptide implicated in addiction to drugs of abuse. Several studies have characterized the role of CART in addiction to psychostimulants, but few have examined the role of CART in alcohol use disorders including alcoholism. The current study utilized a CART knockout (KO) mouse model to investigate the role of CART in ethanol appetitive behaviors. A two-bottle choice, unlimited-access paradigm was used to compare ethanol appetitive behaviors between CART wild type (WT) and KO mice. The mice were presented with an ethanol solution (3%-21%) and water, each concentration for 4 days, and their consumption was measured daily. Consumption of quinine (bitter) and saccharin (sweet) solutions was measured following the ethanol preference tests. In addition, ethanol metabolism rates and ethanol sensitivity were compared between genotypes. CART KO mice consumed and preferred ethanol less than their WT counterparts in both sexes. This genotype effect could not be attributed to differences in bitter or sweet taste perception or ethanol metabolism rates. There was also no difference in ethanol sensitivity in male mice; however, CART KO female mice showed a greater ethanol sensitivity than the WT females. Taken together, these data demonstrate a role for CART in ethanol appetitive behaviors and as a possible therapeutic drug target for alcoholism and abstinence enhancement.

  10. Cocaine- and amphetamine-regulated transcript (CART) protects beta cells against glucotoxicity and increases cell proliferation.

    Science.gov (United States)

    Sathanoori, Ramasri; Olde, Björn; Erlinge, David; Göransson, Olga; Wierup, Nils

    2013-02-01

    Cocaine- and amphetamine-regulated transcript (CART) is an islet peptide that promotes glucose-stimulated insulin secretion in beta cells via cAMP/PKA-dependent pathways. In addition, CART is a regulator of neuronal survival. In this study, we examined the effect of exogenous CART 55-102 on beta cell viability and dissected its signaling mechanisms. Evaluation of DNA fragmentation and chromatin condensation revealed that CART 55-102 reduced glucotoxicity-induced apoptosis in both INS-1 (832/13) cells and isolated rat islets. Glucotoxicity in INS-1 (832/13) cells also caused a 50% reduction of endogenous CART protein. We show that CART increased proliferation in INS-1 (832/13) cells, an effect that was blocked by PKA, PKB, and MEK1 inhibitors. In addition, CART induced phosphorylation of CREB, IRS, PKB, FoxO1, p44/42 MAPK, and p90RSK in INS-1 (832/13) cells and isolated rat islets, all key mediators of cell survival and proliferation. Thus, we demonstrate that CART 55-102 protects beta cells against glucotoxicity and promotes proliferation. Taken together our data point to the potential use of CART in therapeutic interventions targeted at enhancing functional beta cell mass and long-term insulin secretion in T2D.

  11. CART treatment improves memory and synaptic structure in APP/PS1 mice

    Science.gov (United States)

    Jin, Jia-li; Liou, Anthony K.F.; Shi, Yejie; Yin, Kai-lin; Chen, Ling; Li, Ling-ling; Zhu, Xiao-lei; Qian, Lai; Yang, Rong; Chen, Jun; Xu, Yun

    2015-01-01

    Major characteristics of Alzheimer’s disease (AD) include deposits of β-amyloid (Aβ) peptide in the brain, loss of synapses, and cognitive dysfunction. Cocaine- and amphetamine-regulated transcript (CART) has recently been reported to attenuate Aβ-induced toxicity. In this study, CART localization in APP/PS1 mice was characterized and the protective effects of exogenous CART treatment were examined. Compared to age-matched wild type mice, 8-month-old APP/PS1 mice had significantly greater CART immunoreactivity in the hippocampus and cortex. A strikingly similar pattern of Aβ plaque-associated CART immunoreactivity was observed in the cortex of AD cases. Treatment of APP/PS1 mice with exogenous CART ameliorated memory deficits; this effect was associated with improvements in synaptic ultrastructure and long-term potentiation, but not a reduction of the Aβ plaques. Exogenous CART treatment in APP/PS1 mice prevented depolarization of the mitochondrial membrane and stimulated mitochondrial complex I and II activities, resulting in an increase in ATP levels. CART treatment of APP/PS1 mice also reduced reactive oxygen species and 4-hydroxynonenal, and mitigated oxidative DNA damage. In summary, CART treatment reduced multiple neuropathological measures and improved memory in APP/PS1 mice, and may therefore be a promising and novel therapy for AD. PMID:25959573

  12. CryoCart Restoration and Vacuum Pipe Construction

    Science.gov (United States)

    Chaidez, Mariana

    2016-01-01

    first completed at the component level. During this process, the igniter of the main engine and the RCS thrusters will be tested under a vacuum. To complete the testing of the components, the test setup first needed to be finalized. The CryoCart is being used to feed the propellants to the test article. The CryoCart is a movable test set-up that was developed in 2009 to provide a mobile platform for testing oxygen/methane systems with hot-fire capability up to 100 lbf. The CryoCart consists of three different systems: Oxygen, Methane, and liquid Nitrogen. The Oxygen and Methane systems are placed into two different carts while the liquid nitrogen system is mainly located in the methane cart. Over the years, the CryoCart has been utilized for different projects and has undergone deterioration. For this reason, a new phase has been developed to rebuild it to working conditions once again. During my internship, I was aiding in the construction and restoration of the CryoCart. In the initial stages of the process, I updated the fluid and electrical schematics for the oxygen, methane, and test article systems. The original CryoCart consisted of an electrical panel that utilized electromechanical relays and a terminal to drive the igniter power and signal, as well as the main fuel and oxygen valves. This electrical panel connected to the CryoCart through various wire harnesses that could be found exiting from the CryoCart. First, it was determined how these harnesses connected to the electromechanical relays so that they worked correctly. Once the electrical system was understood, an alternative for the electromechanical relays and the Molex connectors used throughout the system was sought since these components can often prove to be unreliable. Solid State relays and MIL connectors were purchased to serve as replacements. Upon arrival of the parts, crimping and wiring was completed to install the new solid state relays and MIL connectors. During the replacement of the relays

  13. Necrotizing fasciitis : plain radiographic and CT findings

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Chang Dae; Park, Jeong Hee; Jeon, Hae Jeong; Lim, Jong Nam; Heo, Tae Haeng; Park, Dong Rib [Konkuk Univ. College of Medicine, Seoul (Korea, Republic of)

    1996-11-01

    To evaluate the plain radiographic and CT findings of the necrotizing fasciitis. We retrospectively reviewed the radiologic findings of 4 cases with necrotizing fasciitis. Three cases were proven pathologically. We evaluated pattern and extent of the gas shadows in plain films. CT findings were analysed, with emphasis on : (a) gas pattern, (b) extent, (c) location and involved site, (d) associated focal abscess, and (e) swelling of the adjacent muscles. On plain radiographs, four cases showed streaky or mottled gas densities in the pelvis, three cases in the perineum, one case in the abdomen, and two cases in the thigh. On CT images, gas pattern was mottled and streaky appearance with swelling of the adjacent muscles. Gas shadows located in the extraperitoneal space in four cases, fascial layer in four cases, and subcutaneous layer in four cases. There were gas shadows in pelvic wall, perineum, abdominal wall, buttock, thigh, and scrotum. Focal low density lesion suggestive of focal abscess was not visualized. Plain radiography is useful for early diagnosis of the necrotizing fasciitis and CT is very useful for detection of precise location and extent of the disease. CT is also useful for differentiation of necrotizing fasciitis from focal abscess and cellulitis.

  14. The use of a cutting balloon in contemporary reverse controlled antegrade and retrograde subintimal tracking (reverse CART) technique.

    Science.gov (United States)

    Nakabayashi, Keisuke; Okada, Hisayuki; Oka, Toshiaki

    2016-07-11

    The key concept of reverse controlled antegrade and retrograde tracking (CART) technique is retrograde puncture with a tapered wire to an antegrade balloon (contemporary reverse CART) or new connections between the antegrade and retrograde subintimal space (classical reverse CART). In our case, a 75-year-old man with severe chronic total occlusion of the right coronary artery, reverse CART with conventional balloons could not be accomplished. Externalization wiring was completed by contemporary reverse CART using a cutting balloon as an antegrade balloon to improve the fenestration force of the retrograde guidewire. Thus, the use of a cutting balloon for contemporary reverse CART might be promising.

  15. Geo-archaeological aspects of the Modena plain (Northern Italy

    Directory of Open Access Journals (Sweden)

    Doriano Castaldini

    2007-12-01

    Full Text Available This paper traces the various stages of geomorphological evolution of the plain area around Modena from the VIth millennium B.C.E. (Neolithic to the Present, through a reconstruction of the ancient landscape and human settlements.By means of a GIS platform, geomorphological investigations led to the implementation of a Microrelief Map, a Digital Elevation Model (DEM, a Map of Surface Deposits and a Geomorphological Map.The most striking altimetric features in the study area are the morphological changes of the Rivers Secchia and Panaro: south of Modena they run deep in the alluvial plain whereas north of the town they flow elevated over the plain. The surface lithology consists mainly of silt, with bands of sand and clay; mainly gravel deposits crop out only near southern tracks of the main Apennine watercourses. The geomorphological landscape is mainly characterised by alluvial fans, fluvial ridges paleo-riverbeds fluvial scarps, natural springs and some depressed areas; worth of note are also forms connected with human activity.There have been several attempts to cross–date geological and geomorphological evidence with archaeological data, on both detailed and wide territorial scales. A further advancement can now be attempted by comparing data obtained from systematic research on fluvial forms with data contained in the archives.In the area studied, some 800 archaeological sites were identified and catalogued. Such a high number of archaeological sites can give a great deal more information than is found in any other place in northern Italy.The research took into account the overlapping of archaeological and geomorphological data, with the implementation into a GIS (ArcGis 8.3 of geoarchaeological maps divided in main periods and here represented from the Neolithic to the to Iron Age and from Roman period to the Early Middle Ages. The dating thus obtained for fluvial forms was mainly based on the relationship between these forms and

  16. Riding in shopping carts and exposure to raw meat and poultry products: prevalence of, and factors associated with, this risk factor for salmonella and campylobacter infection in children younger than 3 years.

    Science.gov (United States)

    Patrick, Mary E; Mahon, Barbara E; Zansky, Shelley M; Hurd, Sharon; Scallan, Elaine

    2010-06-01

    Riding in a shopping cart next to raw meat or poultry is a risk factor for Salmonella and Campylobacter infections in infants. To describe the frequency of, and factors associated with, this behavior, we surveyed parents of children aged younger than 3 years in Foodborne Disease Active Surveillance Network sites. We defined exposure as answering yes to one of a series of questions asking if packages of raw meat or poultry were near a child in a shopping cart, or if a child was in the cart basket at the same time as was raw meat or poultry. Among 1,273 respondents, 767 (60%) reported that their children visited a grocery store in the past week and rode in shopping carts. Among these children, 103 (13%) were exposed to raw products. Children who rode in the baskets were more likely to be exposed than were those who rode only in the seats (odds ratio [OR], 17.8; 95% confidence interval [CI], 11.0 to 28.9). In a multivariate model, riding in the basket (OR, 15.5; 95% CI, 9.2 to 26.1), income less than $55,000 (OR, 1.8; 95% CI, 1.0 to 3.1), and Hispanic ethnicity (OR, 2.3; 95% CI, 1.2 to 4.5) were associated with exposure. Our study shows that children can be exposed to raw meat and poultry products while riding in shopping carts. Parents should separate children from raw products and place children in the seats rather than in the baskets of the cart. Retailer use of leak-proof packaging, customer placement of product in a plastic bag and on the rack underneath the cart, use of hand sanitizers and wipes, and consumer education may also be helpful.

  17. E-Commerce Performance. Shopping Cart Key Performance Indicators

    Directory of Open Access Journals (Sweden)

    Mihaela I. MUNTEAN

    2016-01-01

    Full Text Available In an e-commerce performance framework is important to identify the key performance indicators that measure success and together provide the greatest context into the business perfor-mance. Shopping carts are an essential part of ecommerce, a minimal set of key performance indicators being the subject of our debate. The theoretical approach is sustained by a case study, an e-shop implemented using PHP and MySQL, for simulating main business processes within the considered performance framework. Our approach opens a perspective for future research using additional indicators in order to properly evaluate the global performance of any e-shop.

  18. CART modulates the effects of levodopa in rat model of Parkinson's disease.

    Science.gov (United States)

    Upadhya, Manoj A; Shelkar, Gajanan P; Subhedar, Nishikant K; Kokare, Dadasaheb M

    2016-03-15

    Parkinson's disease (PD) is an age-related disorder characterized by a progressive degeneration of dopaminergic neurons of substantia nigra (SN). The neuropeptide cocaine- and amphetamine-regulated transcript (CART) is known to closely interact with the dopamine system and regulate psychomotor activity. We screened the effectiveness of CART in reversing the symptoms of PD in a rat model. PD like condition was induced by administering 6-hydroxydopamine (6-OHDA) directly in the SN of the right side. Fifteen days later, intraperitoneal (IP) treatment with apomorphine hydrochloride to these rats, resulted in contralateral rotations in the rotation test chamber suggesting induction of PD-like symptoms. This action of apomorphine was significantly attenuated by intracerebroventricular (ICV) treatment with CART and potentiated by CART antibody. IP treatment with levodopa also produced contralateral rotation in PD induced rats, and showed anti-Parkinson-like action. Prior treatment with CART via ICV route potentiated the anti-Parkinsonian effects of levodopa, while CART antibody produced opposite effects. CART treatment per se, to PD induced rats produced ipsilateral rotations, suggesting that the peptide may promote the endogenous release of dopamine from intact neurons. While CART-immunoreactivity in arcuate nucleus, paraventricular nucleus, striatum, substantia nigra, ventral tegmental area and locus coeruleus was reduced in the PD induced rats, levodopa treatment restored the expression of CART-immunoreactivity in these nuclei. These results suggest that endogenous CART might closely interact with the dopamine containing SN-striatal pathway which is known to profoundly influence the motor system. The study underscores the importance of CART as a potential therapeutic agent in the treatment of PD.

  19. Changes in RANKL during the first two years after cART initiation in HIV-infected cART naïve adults

    DEFF Research Database (Denmark)

    Mathiesen, Inger Hee Mabuza; Salem, Mohammad; Gerstoft, Jan

    2017-01-01

    BACKGROUND: By assessing the changes in concentration of soluble receptor activator of nuclear factor κ B ligand (RANKL) and osteoprotegrin (OPG) after initiation of combination antiretroviral therapy (cART) in treatment-naïve HIV-infected patients we aimed to evaluate whether the initial...... accelerated bone loss could be mediated by increased soluble RANKL (sRANKL) levels associated with CD4+ T cell recovery. METHODS: We used multiplex immunoassays to determine sRANKL and OPG concentrations in plasma from 48 HIV patients at baseline and 12, 24, 48 and 96 weeks after cART initiation. RESULTS...... and changes in sRANKL. CONCLUSION: In this study there was no indication that the accelerated bone loss after cART initiation was mediated by early changes in sRANKL due to CD4+ T cell recovery. Future studies should focus on the initial weeks after initiation of cART. TRIAL REGISTRATION: Clinical...

  20. AZ-101 Mixer Pump Demonstration Data Acquisition System and Gamma Cart Data Acquisition Control System Software Configuration Management Plan

    Energy Technology Data Exchange (ETDEWEB)

    WHITE, D.A.

    1999-12-29

    This Software Configuration Management Plan (SCMP) provides the instructions for change control of the AZ1101 Mixer Pump Demonstration Data Acquisition System (DAS) and the Sludge Mobilization Cart (Gamma Cart) Data Acquisition and Control System (DACS).

  1. Identification of the CART neuropeptide circuitry processing TMT-induced predator stress.

    Science.gov (United States)

    Sharma, Anju; Rale, Abhishek; Utturwar, Kaweri; Ghose, Aurnab; Subhedar, Nishikant

    2014-12-01

    Abundance of cocaine- and amphetamine-regulated transcript (CART) neuropeptide in the limbic areas like the olfactory system, central nucleus of amygdala (CeA), ventral bed nucleus of stria terminalis (vBNST) and the hypothalamus suggests involvement of the peptide in emotive processing. We examined the role of CART in mediating fear, a strong emotion with profound survival value. Rats, exposed to 2,4,5-trimethyl-3-thiazoline (TMT), a predator related cue extracted from fox feces, showed significant increase in freezing, escape and risk assessment behavior, whereas grooming was reduced. Neuronal activity was up-regulated in the CeA and vBNST in terms of increased immunoreactivity in CART elements and c-Fos expression. Increased expression of both the markers was also seen in some discrete magnocellular as well as parvicellular subdivisions of the paraventricular nucleus (PVN). However, CART containing mitral cells in the main or accessory olfactory bulb did not respond. CART antibody was stereotaxically injected bilaterally into the CeA to locally immunoneutralize endogenous CART. On exposure to TMT, these rats showed reduced freezing, risk assessment and escape behavior while grooming was restored to normal value. We suggest that the CART signaling in the CeA and vBNST, but not in the olfactory system, might be an important component of the innate fear processing, and expression of stereotypic behavior, while CART in the PVN subdivisions might mediate the neuroendocrine response to predator stress.

  2. Stability of CART peptide expression in the nucleus accumbens in aging.

    Science.gov (United States)

    Armbruszt, Simon; Figler, Mária; Ábrahám, Hajnalka

    2015-03-01

    Aging is accompanied by changes of several anorexigenic and orexigenic neuropeptides expressed in various brain areas that control food intake and these changes correlate with senescent anorexia. During aging expression of cocaine- and amphetamine-regulated transcript (CART) peptide was reported to be reduced in the hypothalamic nuclei related to food intake. Although CART peptide is abundant in the nucleus accumbens that also plays a crucial role in the food intake regulation, no data is available about the CART peptide expression in this region through aging. In the present study, CART peptide immunoreactivity was compared in the nucleus accumbens of young adult (4- and 7-month-old) middle-aged (15-month-old) and aging (25-32-month-old) Long-Evans rats. The density of CART-immunoreactive cells and axon terminals in the nucleus accumbens was measured with computer-aided densitometry. CART-immunodensity was similar in the old rats and in the younger animals without significant difference between age groups. In addition, no gender-difference was observed when CART-immunoreactivities in the nucleus accumbens of male and female animals were compared. Our results indicate that CART peptide expression in the nucleus accumbens is stable in adults and does not change with age.

  3. The carcinine transporter CarT is required in Drosophila photoreceptor neurons to sustain histamine recycling.

    Science.gov (United States)

    Stenesen, Drew; Moehlman, Andrew T; Krämer, Helmut

    2015-12-14

    Synaptic transmission from Drosophila photoreceptors to lamina neurons requires recycling of histamine neurotransmitter. Synaptic histamine is cleared by uptake into glia and conversion into carcinine, which functions as transport metabolite. How carcinine is transported from glia to photoreceptor neurons remains unclear. In a targeted RNAi screen for genes involved in this pathway, we identified carT, which encodes a member of the SLC22A transporter family. CarT expression in photoreceptors is necessary and sufficient for fly vision and behavior. Carcinine accumulates in the lamina of carT flies. Wild-type levels are restored by photoreceptor-specific expression of CarT, and endogenous tagging suggests CarT localizes to synaptic endings. Heterologous expression of CarT in S2 cells is sufficient for carcinine uptake, demonstrating the ability of CarT to utilize carcinine as a transport substrate. Together, our results demonstrate that CarT transports the histamine metabolite carcinine into photoreceptor neurons, thus contributing an essential step to the histamine-carcinine cycle.

  4. CART peptide is a potential endogenous antioxidant and preferentially localized in mitochondria.

    Directory of Open Access Journals (Sweden)

    Peizhong Mao

    Full Text Available The multifunctional neuropeptide Cocaine and Amphetamine Regulated Transcript (CART is secreted from hypothalamus, pituitary, adrenal gland and pancreas. It also can be found in circulatory system. This feature suggests a general role for CART in different cells. In the present study, we demonstrate that CART protects mitochondrial DNA (mtDNA, cellular proteins and lipids against the oxidative action of hydrogen peroxide, a widely used oxidant. Using cis-parinaric acid as a sensitive reporting probe for peroxidation in membranes, and a lipid-soluble azo initiator of peroxyl radicals, 2,2'-azobis(2,4-dimethylvaleronitrile we found that CART is an antioxidant. Furthermore, we found that CART localized to mitochondria in cultured cells and mouse brain neuronal cells. More importantly, pretreatment with CART by systemic injection protects against a mouse oxidative stress model, which mimics the main features of Parkinson's disease. Given the unique molecular structure and biological features of CART, we conclude that CART is an antioxidant peptide (or antioxidant hormone. We further propose that it may have strong therapeutic properties for human diseases in which oxidative stress is strongly involved such as Parkinson's disease.

  5. The carcinine transporter CarT is required in Drosophila photoreceptor neurons to sustain histamine recycling

    Science.gov (United States)

    Stenesen, Drew; Moehlman, Andrew T; Krämer, Helmut

    2015-01-01

    Synaptic transmission from Drosophila photoreceptors to lamina neurons requires recycling of histamine neurotransmitter. Synaptic histamine is cleared by uptake into glia and conversion into carcinine, which functions as transport metabolite. How carcinine is transported from glia to photoreceptor neurons remains unclear. In a targeted RNAi screen for genes involved in this pathway, we identified carT, which encodes a member of the SLC22A transporter family. CarT expression in photoreceptors is necessary and sufficient for fly vision and behavior. Carcinine accumulates in the lamina of carT flies. Wild-type levels are restored by photoreceptor-specific expression of CarT, and endogenous tagging suggests CarT localizes to synaptic endings. Heterologous expression of CarT in S2 cells is sufficient for carcinine uptake, demonstrating the ability of CarT to utilize carcinine as a transport substrate. Together, our results demonstrate that CarT transports the histamine metabolite carcinine into photoreceptor neurons, thus contributing an essential step to the histamine–carcinine cycle. DOI: http://dx.doi.org/10.7554/eLife.10972.001 PMID:26653853

  6. Birmanie-Thaïlande: un écart croissant

    Directory of Open Access Journals (Sweden)

    Michel BRUNEAU

    1991-03-01

    Full Text Available Deux royaumes (Birmanie et Siam très proches l’un de l’autre culturellement et dans leurs structures socio-politiques ont vu, au cours des deux siècles derniers, leur richesse économique relative s’inverser l’un par rapport à l’autre en fonction de leur degré d’intégration au commerce international et au capitalisme occidental. Depuis la seconde guerre mondiale, l’écart n’a cessé de se creuser en faveur de la Thaïlande, qui est en train de rejoindre les Nouveaux Pays Industriels. Une cartographie de synthèse montre l’alternance de la richesse économique et l’écart qui n’a cessé de se creuser. L’Asie du Sud-Est continentale naguère déchirée, écartelée par les dominations extérieures (impérialismes britannique et français, puis nippo-américain a tendance à se recomposer en un ensemble dominé par la Thaïlande qui s’affirme de plus en plus comme la puissance économique centrale de la péninsule indochinoise.

  7. Injection of Cocaine-Amphetamine Regulated Transcript (CART) peptide into the nucleus accumbens does not inhibit caffeine-induced locomotor activity: Implications for CART peptide mechanism.

    Science.gov (United States)

    Job, Martin O

    2016-09-01

    Much evidence suggests that intra-nucleus accumbens (NAc) CART peptide (CART 55-102) injection inhibits locomotor activity (LMA) when there is an increase in the release and activity of dopamine (DA) in the NAc. However, this hypothesis has not been fully tested. One way to examine this is to determine if there is a lack of effect of intra-NAc CART peptide on LMA that does not involve increases in DA release in the NAc. Several studies have suggested that caffeine-induced LMA does not involve extracellular DA release in the NAc core. Therefore, in this study, we have examined the effect of injections of CART peptide (2.5μg) into the NAc core on the locomotor effects of caffeine in male Sprague-Dawley rats. Several LMA relevant doses of caffeine were used (0, 10, 20mg/kg i.p.), and an inverted U response curve was found as expected. We determined, in the same animals, that intra-NAc CART peptide had no effect on caffeine-induced LMA whereas it blunted cocaine-mediated LMA, as shown by other reports. We also extended a previous observation in mice by showing that at a LMA activating dose of caffeine there is no alteration of CART peptide levels in the NAc of rats. Our study supports the hypothesis that the inhibitory effects of CART peptide in the NAc may be exerted only under conditions of increased extracellular DA release and activity in this region. Our results also suggest that intra-NAc CART 55-102 does not generally inhibit increases in LMA due to all drugs, but has a more specific inhibitory effect on dopaminergic neurotransmission.

  8. Neurological Response to cART vs. cART plus Integrase Inhibitor and CCR5 Antagonist Initiated during Acute HIV.

    Directory of Open Access Journals (Sweden)

    Victor G Valcour

    Full Text Available To compare central nervous system (CNS outcomes in participants treated during acute HIV infection with standard combination antiretroviral therapy (cART vs. cART plus integrase inhibitor and CCR5 antagonist (cART+.24-week randomized open-label prospective evaluation.Participants were evaluated then randomized to initiate cART (efavirenz, tenofovir, and either emtricitabine or lamivudine vs. cART+ (cART plus raltegravir and maraviroc during acute HIV and re-evaluated at 4, 12 and 24 weeks. We examined plasma and CSF cytokines, HIV RNA levels, neurological and neuropsychological findings, and brain MRS across groups and compared to healthy controls.At baseline, 62 participants were in Fiebig stages I-V. Randomized groups were similar for mean age (27 vs. 25, p = 0.137, gender (each 94% male, plasma log10 HIV RNA (5.4 vs. 5.6, p = 0.382, CSF log10 HIV RNA (2.35 vs. 3.31, p = 0.561, and estimated duration of HIV (18 vs. 17 days, p = 0.546. Randomized arms did not differ at 24 weeks by any CNS outcome. Combining arms, all measures concurrent with antiretroviral treatment improved, for example, neuropsychological testing (mean NPZ-4 of -0.408 vs. 0.245, p<0.001 and inflammatory markers by MRS (e.g. mean frontal white matter (FWM choline of 2.92 vs. 2.84, p = 0.045 at baseline and week 24, respectively. Plasma neopterin (p<0.001 and interferon gamma-induced protein 10 (IP-10 (p = 0.007 remained elevated in participants compared to controls but no statistically significant differences were seen in CSF cytokines compared to controls, despite individual variability among the HIV-infected group.A 24-week course of cART+ improved CNS related outcomes, but was not associated with measurable differences compared to standard cART.

  9. Neurological Response to cART vs. cART plus Integrase Inhibitor and CCR5 Antagonist Initiated during Acute HIV

    Science.gov (United States)

    Valcour, Victor G.; Spudich, Serena S.; Sailasuta, Napapon; Phanuphak, Nittaya; Lerdlum, Sukalaya; Fletcher, James L. K.; Kroon, Eugene D. M. B.; Jagodzinski, Linda L.; Allen, Isabel E.; Adams, Collin L.; Prueksakaew, Peeriya; Slike, Bonnie M.; Hellmuth, Joanna M.; Kim, Jerome H.; Ananworanich, Jintanat

    2015-01-01

    Objective To compare central nervous system (CNS) outcomes in participants treated during acute HIV infection with standard combination antiretroviral therapy (cART) vs. cART plus integrase inhibitor and CCR5 antagonist (cART+). Design 24-week randomized open-label prospective evaluation. Method Participants were evaluated then randomized to initiate cART (efavirenz, tenofovir, and either emtricitabine or lamivudine) vs. cART+ (cART plus raltegravir and maraviroc) during acute HIV and re-evaluated at 4, 12 and 24 weeks. We examined plasma and CSF cytokines, HIV RNA levels, neurological and neuropsychological findings, and brain MRS across groups and compared to healthy controls. Results At baseline, 62 participants were in Fiebig stages I-V. Randomized groups were similar for mean age (27 vs. 25, p = 0.137), gender (each 94% male), plasma log10 HIV RNA (5.4 vs. 5.6, p = 0.382), CSF log10 HIV RNA (2.35 vs. 3.31, p = 0.561), and estimated duration of HIV (18 vs. 17 days, p = 0.546). Randomized arms did not differ at 24 weeks by any CNS outcome. Combining arms, all measures concurrent with antiretroviral treatment improved, for example, neuropsychological testing (mean NPZ-4 of -0.408 vs. 0.245, p<0.001) and inflammatory markers by MRS (e.g. mean frontal white matter (FWM) choline of 2.92 vs. 2.84, p = 0.045) at baseline and week 24, respectively. Plasma neopterin (p<0.001) and interferon gamma-induced protein 10 (IP-10) (p = 0.007) remained elevated in participants compared to controls but no statistically significant differences were seen in CSF cytokines compared to controls, despite individual variability among the HIV-infected group. Conclusions A 24-week course of cART+ improved CNS related outcomes, but was not associated with measurable differences compared to standard cART. PMID:26555069

  10. Pediatric shopping-cart-related injuries treated in US emergency departments, 1990-2011.

    Science.gov (United States)

    Martin, Keith J; Chounthirath, Thiphalak; Xiang, Huiyun; Smith, Gary A

    2014-03-01

    This study investigates the effect of the 2004 US shopping cart safety standard on shopping-cart-related injuries among children younger than 15 years of age by retrospectively analyzing data from the National Electronic Injury Surveillance System. An estimated 530 494 children younger than 15 years were treated in US emergency departments for shopping-cart-related injuries from 1990 to 2011, averaging 24 113 children annually. The most commonly injured body region was the head (78.1%). The annual concussion/closed head injury rate per 10 000 children increased significantly (P shopping cart safety standard was implemented in the United States in 2004, the overall number and rate of injuries associated with shopping carts have not decreased. In fact, the number and rate of concussions/closed head injuries have continued to climb. Increased prevention efforts are needed to address these injuries among children.

  11. CART peptide and opioid addiction: Expression changes in male rat brain.

    Science.gov (United States)

    Bakhtazad, A; Vousooghi, N; Garmabi, B; Zarrindast, M R

    2016-06-14

    Previous studies have shown the prominence of cocaine- and amphetamine-regulated transcript (CART) peptide in rewarding and reinforcing effects of drugs of abuse specially psychostimulants. The data regarding the effects of different stages of opioid addiction on CART expression and the interconnection between CART and opioids are not much available. Here we have studied the changes in the expression level of CART mRNA and protein in various parts of the brain reward pathway in different stages of opioid addiction. Groups of male rats received acute low-dose (10mg/kg), acute high-dose (80mg/kg) and chronic escalating doses of morphine. In addition, withdrawal and abstinence states were evaluated after injection of naloxone (1mg/kg) and long-term maintenance of addicted animals, respectively. Expression of CART mRNA in the brain was measured by real-time PCR method. Western blotting was used to quantify the protein level. CART mRNA and protein were both up-regulated in high-dose morphine-administered animals and also in the withdrawal group in the nucleus accumbens (NAc), striatum and prefrontal cortex (PFC). In the addicted group, CART mRNA and protein were both down-regulated in NAc and striatum. In the abstinent group, CART mRNA was down-regulated in NAc. In the hippocampus, the only observed change was the up-regulation of CART mRNA in the withdrawal group. We suggest that the modulatory role of CART peptide in rewarding and reinforcing effects of opioids weakens when opioids are used for a long time and is stimulated when acute stress such as naloxone-induced withdrawal syndrome or acute high-dose administration of morphine occurs to the animal.

  12. Specific yield, High Plains aquifer

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This raster data set represents specific-yield ranges in the High Plains aquifer of the United States. The High Plains aquifer underlies 112.6 million acres (176,000...

  13. Environmental changes and human activities around the Youzhougang site in Liyang Plain based on pollen analysis%澧阳平原优周岗遗址孢粉记录的环境变化与人类活动

    Institute of Scientific and Technical Information of China (English)

    郭媛媛; 莫多闻; 毛龙江; 郭伟民

    2016-01-01

    通过对澧阳平原优周岗遗址剖面沉积样品孢粉分析,重建了该区5500 a B.P.~4000 a B.P.气候、水文、植被变化和人类活动历史.结果表明:距今5500~5200年大溪文化晚期,气候环境较为适宜;距今5200~4000年的屈家岭—石家河文化时期,气候暖湿程度先升高后降低,转折点在4800 a B.P.左右.其中,距今4200~4000年的石家河文化晚期,气候向干凉化发展.孢粉组合显示优周岗遗址周边一直有湿润生境存在,且在屈家岭文化中晚期和石家河晚期出现湿生草本、蕨类孢子和藻类的明显增加,反映两次水文变化过程.优周岗遗址大溪文化时期常绿和落叶阔叶林已遭破坏,稻作农业有一定发展,屈家岭—石家河文化早中期稻作规模扩展.然而石家河文化晚期,稻作农业规模明显收缩,可能与区域文化衰落有一定关系.%Based on pollen analysis of sediment samples collected from the profiles at the Youzhougang site in Liyang Plain,we explored the climatic and hydrological changes,vegetation history,and human activities during 5500-4000 a B.P.The results showed that the climate was relatively warm and humid during the Late Daxi cultural period (5500-5200 a B.P.),and then it became warmer and wetter during the early and middle Qujialing cultural stage which spanned approximately from 5200 to 4800 a B.P.A gradual climatic transition from warm and humid condition to cool and dry condition occurred in the late Qujialing cultural stage,and early and middle Shijiahe cultural stage (4800-4200 a B.P.).However,the climate was still relatively favorable to humans on the whole.The climate deteriorated significantly during the late Shijiahe cultural period (4200-4000 a B.P.),which was characterized by unstable cool and dry condition.Moreover,our pollen analysis revealed hydrological changes in our study site.We found small wetlands around the Youzhougang site,and from the significant increase in the proportion of

  14. Immunohistochemical distribution of cocaine and amphetamine regulatory peptide-like immunoreactive (CART-LI) nerve fibers in the circular muscle layer and their relationship to other peptides in the human caecum.

    Science.gov (United States)

    Bulc, Michał; Gonkowski, Sławomir; Landowski, Piotr; Kamińska, Barbara; Całka, Jarosław

    2014-07-01

    Motor activity of the gastrointestinal tract is extensively controlled by the enteric nervous system (ENS). Numerous neurotransmitters and neuromodulators are responsible for this regulation. One of them is cocaine- and amphetamine-regulated transcript peptide (CART). So far, there are few reports available concerning the distribution, functions, and co-localization of CART in the human gastrointestinal tract. The aim of the present investigation was to study the distribution and degree of co-localization of CART with substances taking part in conducting sensory stimuli, such as: substance P (SP), neurokinin A (NKA), calcitonin gene related peptide (CGRP) and Leu 5 enkephalin (L-ENK) in the circular muscle layer of the human caecum. CART-like immunoreactive (CART-LI) nerve fibers formed a very dense meshwork in the circular muscle layer of the caecum in all patients studied. Moreover, all neuronal substances tested during the present investigation were observed in CART-LI processes, but the degree of co-localization depended on the type of substance. The highest number of CART-positive nerves also contained L-ENK. A slightly lower level of co-localization was observed in the case of CART and SP or NKA, while only single nerve fibers were simultaneously CART- and CGRP-positive.

  15. 永不落空的"CART"法

    Institute of Scientific and Technical Information of China (English)

    薛福连

    2001-01-01

    @@ 在一本由罗伯特·哈夫所著的国外畅销书籍《如何在这个疯狂世界里找到一份好工作》中,提出了四种谋得理想工作的方法,的确为"四字真言".它们用英文表达的是"CART"即"Contacts(熟人门路);Advertisement(广告);Recruiter(招聘者);Temporary(临时职位).细细一想,简单的四个英文字母蕴含的却是求职的精华.毕竟,找工作有找工作的窍门,不掌握这些窍门理想的工作绝不会自己送上门来.

  16. Meta-CART: A tool to identify interactions between moderators in meta-analysis.

    Science.gov (United States)

    Li, Xinru; Dusseldorp, Elise; Meulman, Jacqueline J

    2017-02-01

    In the framework of meta-analysis, moderator analysis is usually performed only univariately. When several study characteristics are available that may account for treatment effect, standard meta-regression has difficulties in identifying interactions between them. To overcome this problem, meta-CART has been proposed: an approach that applies classification and regression trees (CART) to identify interactions, and then subgroup meta-analysis to test the significance of moderator effects. The previous version of meta-CART has its shortcomings: when applying CART, the sample sizes of studies are not taken into account, and the effect sizes are dichotomized around the median value. Therefore, this article proposes new meta-CART extensions, weighting study effect sizes by their accuracy, and using a regression tree to avoid dichotomization. In addition, new pruning rules are proposed. The performance of all versions of meta-CART was evaluated via a Monte Carlo simulation study. The simulation results revealed that meta-regression trees with random-effects weights and a 0.5-standard-error pruning rule perform best. The required sample size for meta-CART to achieve satisfactory performance depends on the number of study characteristics, the magnitude of the interactions, and the residual heterogeneity.

  17. Identification and differential distribution of CART in the small intestine depending on the diet.

    Science.gov (United States)

    Janiuk, I; Olkowski, B; Szczotka-Bochniarz, A

    2014-12-01

    This study was aimed at identifying and locating cocaine- and amphetamine-regulated transcript (CART) in the small intestine of broilers in relation to the diet. The feeding regime of the chicks was based on diets largely consisting of maize and one of four protein sources: post-extraction soya bean meal (SBM) or non-GM seed meal - meal from traditional variety of soy seeds Glicine max (FFS) and meal from seeds of Lupinus angustifolius (LA) and Lupinus luteus L (LY). The presence of cocaine- and amphetamine-regulated transcript immunoreactive (CART-IR) in the wall of the small intestine of the chicks was determined on the basis of staining patterns produced by the immunohistochemical method (IHC). CART-IR structures were found in the myenteric plexus (MP), submucosus plexus (SP), in endomucosal fibres, and fibres innervating miocytes and blood vessels in the muscularis membrane and adipocytes of the white adipose tissue (WAT) located on the perimeter of the serous membrane and single cells of the diffuse neuroendocrine system. Based on microscopic observation and result analysis, the lowest number of CART-IR structures was identified in the group that was fed the SBM-based diet. This study confirms previous observations concerning CART distribution in the gastrointestinal tract (GIT) of animal and broadens current knowledge by inclusion of chicken in the list of CART-positive species. Moreover, this work provides evidence that dietary composition can be a factor that stimulates post-prandial CART secretion in intestinal nerve structures.

  18. Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy

    Directory of Open Access Journals (Sweden)

    Vita Golubovskaya

    2016-03-01

    Full Text Available This review is focused on different subsets of T cells: CD4 and CD8, memory and effector functions, and their role in CAR-T therapy––a cellular adoptive immunotherapy with T cells expressing chimeric antigen receptor. The CAR-T cells recognize tumor antigens and induce cytotoxic activities against tumor cells. Recently, differences in T cell functions and the role of memory and effector T cells were shown to be important in CAR-T cell immunotherapy. The CD4+ subsets (Th1, Th2, Th9, Th17, Th22, Treg, and Tfh and CD8+ memory and effector subsets differ in extra-cellular (CD25, CD45RO, CD45RA, CCR-7, L-Selectin [CD62L], etc.; intracellular markers (FOXP3; epigenetic and genetic programs; and metabolic pathways (catabolic or anabolic; and these differences can be modulated to improve CAR-T therapy. In addition, CD4+ Treg cells suppress the efficacy of CAR-T cell therapy, and different approaches to overcome this suppression are discussed in this review. Thus, next-generation CAR-T immunotherapy can be improved, based on our knowledge of T cell subsets functions, differentiation, proliferation, and signaling pathways to generate more active CAR-T cells against tumors.

  19. An ergonomic evaluation of handle height and load in maximal and submaximal cart pushing.

    Science.gov (United States)

    Resnick, M L; Chaffin, D B

    1995-06-01

    Awareness of the hazards of repetitive lifting has brought about significant changes in the design of industrial jobs. Pushing and pulling tasks have become increasingly common as the result of the introduction of a variety of carts and other materials-handling assistance devices. In order to predict the peak performance of workers in these tasks, and the biomechanical stresses that can result from them, the exertions involved in cart pushing were studied. Four subjects of various strengths pushed carts with loads from 45 to 450 kg at several heights. Peak push forces reached 500 N for male subjects and 200 N for female subjects. Strong subjects moved a 45 kg cart at velocities of 1.1 m s(-1) and a 450 kg cart at velocities of 0.8 m s(-1). Weaker subjects moved the carts at velocities of 0.5 and 0.4 m s(-1) respectively. Calculated static compression forces at the L5/S1 spinal disc were consistently above the NIOSH Action Limit of 3400 N for strong subjects when the cart load reached 225 kg.

  20. Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy.

    Science.gov (United States)

    Golubovskaya, Vita; Wu, Lijun

    2016-01-01

    This review is focused on different subsets of T cells: CD4 and CD8, memory and effector functions, and their role in CAR-T therapy--a cellular adoptive immunotherapy with T cells expressing chimeric antigen receptor. The CAR-T cells recognize tumor antigens and induce cytotoxic activities against tumor cells. Recently, differences in T cell functions and the role of memory and effector T cells were shown to be important in CAR-T cell immunotherapy. The CD4⁺ subsets (Th1, Th2, Th9, Th17, Th22, Treg, and Tfh) and CD8⁺ memory and effector subsets differ in extra-cellular (CD25, CD45RO, CD45RA, CCR-7, L-Selectin [CD62L], etc.); intracellular markers (FOXP3); epigenetic and genetic programs; and metabolic pathways (catabolic or anabolic); and these differences can be modulated to improve CAR-T therapy. In addition, CD4⁺ Treg cells suppress the efficacy of CAR-T cell therapy, and different approaches to overcome this suppression are discussed in this review. Thus, next-generation CAR-T immunotherapy can be improved, based on our knowledge of T cell subsets functions, differentiation, proliferation, and signaling pathways to generate more active CAR-T cells against tumors.

  1. CART III: improved camouflage assessment using moving target indication

    Science.gov (United States)

    Müller, Thomas; Honke, Thomas; Müller, Markus

    2009-05-01

    In order to facilitate systematic, computer aided improvements of camouflage and concealment assessment methods, the software system CART (Camouflage Assessment in Real-Time) was built up for the camouflage assessment of objects in image sequences (see contributions to SPIE 2007 and SPIE 2008 [1], [2]). It works with visual-optical, infrared and SAR image sequences. The system comprises a semi-automatic annotation functionality for marking target objects (ground truth generation) including a propagation of those markings over the image sequence for static as well as moving scene objects, where the recording camera may be static or moving. The marked image regions are evaluated by applying user-defined feature extractors, which can easily be defined and integrated into the system via a generic software interface. This article presents further systematic enhancements made in the recent year and addresses particularly the task of the detection of moving vehicles by latest image exploitation methods for objective camouflage assessment in these cases. As a main topic, the loop was closed between the two natural opposites of reconnaissance and camouflage, which was realized by incorporating ATD (Automatic Target Detection) algorithms into the computer aided camouflage assessment. Since object (and sensor) movement is an important feature for many applications, different image-based MTI (Moving Target Indication) algorithms were included in the CART system, which rely on changes in the image plane from an image to the successive one (after camera movements are automatically compensated). Additionally, the MTI outputs over time are combined in a certain way which we call "snail track" algorithm. The results show that their output provides a valuable measurement for the conspicuity of moving objects and therefore is an ideal component in the camouflage assessment. It is shown that image-based MTI improvements lead to improvements in the camouflage assessment process.

  2. Evaluation of density and distribution of CART-immunoreactive structures in gastrointestinal tract of hypertensive rats.

    Science.gov (United States)

    Kasacka, Irena; Piotrowska, Zaneta

    2012-01-01

    The prevalence of CART (cocaine- and amphetamine-regulated transcript) throughout the organism, multiplicity of functions fulfilled by that peptide, and the collected evidence confirming CART contribution to blood pressure regulation prompted us to undertake the research aiming to identify, localize, and assess changes in CART-immunopositive structures of the gastrointestinal tract (GI tract) of rats with renovascular hypertension. The two-kidney one-clip model of arterial hypertension was used to evaluate the location and density of CART-containing structures in the stomach (cardia, fundus, and pylorus), duodenum, jejunum, ileum, and colon of hypertensive rats. The study was carried out on the GI tract of 20 rats. Ten rats were subjected to the renal artery clipping procedure and after a 6-week period each of them developed stable hypertension. An immunohistochemical localization of CART was performed on paraffin GI tract sections from all the study animals. CART was detected in the extensive population of neurons, particularly within the myenteric plexuses all along the GI tract, and also in neuroendocrine cells, being especially numerous in the stomach and a few in the small intestine. The hypertension significantly increased the density of CART-positive structures in the rat GI tract. The differences between the hypertensive rats and the control animals concerned not only the density of CART-immunoreactive structures but also the staining intensity. As this study provides novel findings, we are planning further molecular examinations to better understand the impact of hypertension on the functioning and activity of CART in the GI tract.

  3. New analogs of the CART peptide with anorexigenic potency: the importance of individual disulfide bridges.

    Science.gov (United States)

    Blechová, Miroslava; Nagelová, Veronika; Záková, Lenka; Demianová, Zuzana; Zelezná, Blanka; Maletínská, Lenka

    2013-01-01

    The CART (cocaine- and amphetamine-regulated transcript) peptide is an anorexigenic neuropeptide that acts in the hypothalamus. The receptor and the mechanism of action of this peptide are still unknown. In our previous study, we showed that the CART peptide binds specifically to PC12 rat pheochromocytoma cells in both the native and differentiated into neuronal phenotype. Two biologically active forms, CART(55-102) and CART(61-102), with equal biological activity, contain three disulfide bridges. To clarify the importance of each of these disulfide bridges in maintaining the biological activity of CART(61-102), an Ala scan at particular S-S bridges forming cysteines was performed, and analogs with only one or two disulfide bridges were synthesized. In this study, a stabilized CART(61-102) analog with norleucine instead of methionine at position 67 was also prepared and was found to bind to PC12 cells with an anorexigenic potency similar to that of CART(61-102). The binding study revealed that out of all analogs tested, [Ala(68,86)]CART(61-102), which contains two disulfide bridges (positions 74-94 and 88-101), preserved a high affinity to both native PC12 cells and those that had been differentiated into neurons. In food intake and behavioral tests with mice after intracerebroventricular administration, this analog showed strong and long-lasting anorexigenic potency. Therefore, the disulfide bridge between cysteines 68 and 86 in CART(61-102) can be omitted without a loss of biological activity, but the preservation of two other disulfide bridges and the full-length peptide are essential for biological activity.

  4. Quantitative evaluation of CART-containing cells in urinary bladder of rats with renovascular hypertension.

    Science.gov (United States)

    Janiuk, I; Kasacka, I

    2015-04-13

    Recent biological advances make it possible to discover new peptides associated with hypertension. The cocaine- and amphetamine-regulated transcript (CART) is a known factor in appetite and feeding behaviour. Various lines of evidence suggest that this peptide participates not only in control of feeding behaviour but also in the regulation of the cardiovascular and sympathetic systems and blood pressure. The role of CART in blood pressure regulation led us to undertake a study aimed at analysing quantitative changes in CART-containing cells in urinary bladders (UB) of rats with renovascular hypertension. We used the Goldblatt model of arterial hypertension (two-kidney, one clip) to evaluate quantitative changes. This model provides researchers with a commonly used tool to analyse the renin-angiotensin system of blood pressure control and, eventually, to develop drugs for the treatment of chronic hypertension. The study was performed on sections of urinary bladders of rats after 3-, 14-, 28-, 42 and 91 days from hypertension induction. Immunohistochemical identification of CART cells was performed on paraffin for the UBs of all the study animals. CART was detected in the endocrine cells, especially numerous in the submucosa and muscularis layers, with a few found in the transitional epithelium and only occasionally in serosa. Hypertension significantly increased the number of CART-positive cells in the rat UBs. After 3 and 42 days following the procedure, statistically significantly higher numbers of CART-positive cells were identified in comparison with the control animals. The differences between the hypertensive rats and the control animals concerned not only the number density of CART-immunoreactive cells but also their localization. After a 6-week period, each of the rats subjected to the renal artery clipping procedure developed stable hypertension. CART appeared in numerous transitional epithelium cells. As this study provides novel findings, the question

  5. Discontinuation of cART postpartum in a high prevalence district of South Africa in 2014

    OpenAIRE

    2014-01-01

    Background Combination antiretroviral therapy (cART) is the current strategy to prevent mother-to-child transmission (PMTCT) of HIV. Women initiated on cART should continue taking treatment life-long or stop after cessation of breastfeeding depending on their CD4 cell count or on their World Health Organization (WHO) staging. Keeping people living with HIV on treatment is essential for the success of any antiretroviral therapy (ART) programme. There has been a rapid scale-up of cART in the PM...

  6. Quantitative Evaluation of CART-Containing Cells in Urinary Bladder of Rats with Renovascular Hypertension

    Science.gov (United States)

    Janiuk, I.; Kasacka, I.

    2015-01-01

    Recent biological advances make it possible to discover new peptides associated with hypertension. The cocaine- and amphetamine-regulated transcript (CART) is a known factor in appetite and feeding behaviour. Various lines of evidence suggest that this peptide participates not only in control of feeding behaviour but also in the regulation of the cardiovascular and sympathetic systems and blood pressure. The role of CART in blood pressure regulation led us to undertake a study aimed at analysing quantitative changes in CART-containing cells in urinary bladders (UB) of rats with renovascular hypertension. We used the Goldblatt model of arterial hypertension (two-kidney, one clip) to evaluate quantitative changes. This model provides researchers with a commonly used tool to analyse the renin-angiotensin system of blood pressure control and, eventually, to develop drugs for the treatment of chronic hypertension. The study was performed on sections of urinary bladders of rats after 3-, 14-, 28-, 42 and 91 days from hypertension induction. Immunohistochemical identification of CART cells was performed on paraffin for the UBs of all the study animals. CART was detected in the endocrine cells, especially numerous in the submucosa and muscularis layers, with a few found in the transitional epithelium and only occasionally in serosa. Hypertension significantly increased the number of CART-positive cells in the rat UBs. After 3 and 42 days following the procedure, statistically significantly higher numbers of CART-positive cells were identified in comparison with the control animals. The differences between the hypertensive rats and the control animals concerned not only the number density of CART-immunoreactive cells but also their localization. After a 6-week period, each of the rats subjected to the renal artery clipping procedure developed stable hypertension. CART appeared in numerous transitional epithelium cells. As this study provides novel findings, the question

  7. Quantitative evaluation of CART-containing cells in urinary bladder of rats with renovascular hypertension

    Directory of Open Access Journals (Sweden)

    I. Janiuk

    2015-04-01

    Full Text Available Recent biological advances make it possible to discover new peptides associated with hypertension. The cocaine- and amphetamine-regulated transcript (CART is a known factor in appetite and feeding behaviour. Various lines of evidence suggest that this peptide participates not only in control of feeding behaviour but also in the regulation of the cardiovascular and sympathetic systems and blood pressure. The role of CART in blood pressure regulation led us to undertake a study aimed at analysing quantitative changes in CART-containing cells in urinary bladders (UB of rats with renovascular hypertension. We used the Goldblatt model of arterial hypertension (two-kidney, one clip to evaluate quantitative changes. This model provides researchers with a commonly used tool to analyse the renin-angiotensin system of blood pressure control and, eventually, to develop drugs for the treatment of chronic hypertension. The study was performed on sections of urinary bladders of rats after 3-, 14-, 28-, 42 and 91 days from hypertension induction. Immunohistochemical identification of CART cells was performed on paraffin for the UBs of all the study animals. CART was detected in the endocrine cells, especially numerous in the submucosa and muscularis layers, with a few found in the transitional epithelium and only occasionally in serosa. Hypertension significantly increased the number of CART-positive cells in the rat UBs. After 3 and 42 days following the procedure, statistically significantly higher numbers of CART-positive cells were identified in comparison with the control animals. The differences between the hypertensive rats and the control animals concerned not only the number density of CART-immunoreactive cells but also their localization. After a 6-week period, each of the rats subjected to the renal artery clipping procedure developed stable hypertension. CART appeared in numerous transitional epithelium cells. As this study provides novel findings

  8. 北京平原困难立地油松人工林营造新材料应用%Research on applying new materials for Pinus tabuliformis plantations in barren sites of plain in Beijing

    Institute of Scientific and Technical Information of China (English)

    李媚; 贾黎明; 于丹丹; 马履一; 贾忠奎

    2015-01-01

    为探寻适用于北京平原造林工程中困难立地条件下油松等大规格针叶苗木成活、成林及健康生长的最佳新材料施用方案,将抗蒸腾抑制剂、厚环乳牛肝菌剂以及6号GGR植物生长调节剂3种造林新材料进行组合试验,对油松林的造林成活率、当年新梢数量、新梢长度、新梢直径、叶绿素含量以及叶片营养元素进行调查研究. 结果表明:1)施用造林新材料的处理成活率均高于对照(78%),其中HSK(厚环乳牛杆菌剂+6 号GGR植物生长调节剂+抗蒸腾抑制剂)处理成活率最高,达到89%;2)油松新梢生长情况以HSK处理表现最优,2013年5—7月新梢数量平均增长量最大,单株平均增长量为6.48个,是对照增长量的2倍;新梢直径的平均增长量为2.36 mm,相对于对照提高了117%;新梢长度增长量较对照增长量提高了251%;3)油松叶片2013年总叶绿素含量平均值以HSK处理最高,为6.96 mg/L,对照处理最低,为5.76 mg/L,且3种新材料之间存在明显的相互促进作用;4)对于叶片营养元素含量,在HSK处理条件下,2013年叶片P元素总平均含量达0.81 g/kg、叶片N元素为10.01 mg/kg、叶片K元素为5.41 g/kg,优于其他处理,即HSK处理可确保3种营养元素均稳定维持在较高水平. 5)为确保林分结构稳定,各处理死亡油松苗木需重新补植,尽管相对于对照,其余处理新材料的施用增加了成本,但其对成活率的提高可以很大程度上节省补植所需资金,其中以HSK处理( 100 株油松占地0.17 hm2 )节约成本最高( 810 元) ,即4 764元/hm2.因此综合考虑各指标,HSK处理在前期保证苗木成活率及后期促进苗木生长发育等方面均表现出明显的优越性.%To seek the implementation solutions of using new materials for the seedling survival, growth and health of large size coniferous forest such as Pinus tabuliformis under barren site condition in the Beijing Plain Afforestation Project

  9. Southeastern Coastal Plain aquifer system

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set represents the extent of the Southeastern Coastal Plain aquifer system in Kentucky, Tennessee, Mississippi, Alabama, Georgia, and South Carolina.

  10. DEMOGRAPHIC VULNERABILITIES IN TECUCI PLAIN

    Directory of Open Access Journals (Sweden)

    Iulian Adrian ŞORCARU

    2013-06-01

    Full Text Available The study focuses on analyzing and mapping 8 indicators considered to best reflect the demographic vulnerability in Tecuci Plain in the year 2010 and proposes a model of aggregation which finally allows us to distinguish three major types of demographic vulnerability (low, medium and high. Mapping the final values also shows significant disparities in the territorial administrative units that broadly overlap the plain, the most vulnerable being Tecuci city and the peripheral communes, towards Vrancea and Vaslui Counties.

  11. Mathematical modelling of translational motion of rail-guided cart with suspended payload

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    In this paper modelling of the translational motion of transportation rail-guided cart with rope suspended payload is considered. The linearly moving cart, driven by a travel mechanism, is modelled as a discrete six degrees of freedom (DOF) dynamic system. The hoisting mechanism for lowering and lifting the payload is considered and is included in the dynamic model as one DOF system. Differential equations of motion of the cart elements are derived using Lagrangian dynamics and are solved for a set of real-life constant parameters of the cart. A two-sided interaction was observed between the swinging payload and the travel mechanism. Results for kinematical and force parameters of the system are obtained. A verification of the proposed model was conducted.

  12. The Communities Advancing Resilience Toolkit (CART): an intervention to build community resilience to disasters.

    Science.gov (United States)

    Pfefferbaum, Rose L; Pfefferbaum, Betty; Van Horn, Richard L; Klomp, Richard W; Norris, Fran H; Reissman, Dori B

    2013-01-01

    Community resilience has emerged as a construct to support and foster healthy individual, family, and community adaptation to mass casualty incidents. The Communities Advancing Resilience Toolkit (CART) is a publicly available theory-based and evidence-informed community intervention designed to enhance community resilience by bringing stakeholders together to address community issues in a process that includes assessment, feedback, planning, and action. Tools include a field-tested community resilience survey and other assessment and analytical instruments. The CART process encourages public engagement in problem solving and the development and use of local assets to address community needs. CART recognizes 4 interrelated domains that contribute to community resilience: connection and caring, resources, transformative potential, and disaster management. The primary value of CART is its contribution to community participation, communication, self-awareness, cooperation, and critical reflection and its ability to stimulate analysis, collaboration, skill building, resource sharing, and purposeful action.

  13. Shopper marketing nutrition interventions: Social norms on grocery carts increase produce spending without increasing shopper budgets

    Directory of Open Access Journals (Sweden)

    Collin R. Payne

    2015-01-01

    Conclusions: Descriptive and provincial social norm messages (i.e., on grocery cart placards may be an overlooked tool to increase produce demand without decreasing store profitability and increasing shopper budgets.

  14. Management of animal energy resources and the modernization of the bullock-cart system

    Energy Technology Data Exchange (ETDEWEB)

    Ramaswamy, N.S.

    1979-01-01

    The significance of animal energy, especially in the transportation sector to the economies of India, China, Indonesia and other countries and the redesign of bullock-carts for more efficient use of animal energy are discussed. (LCL)

  15. Pro-cognitive action of CART is mediated via ERK in the hippocampus.

    Science.gov (United States)

    Bharne, Ashish P; Borkar, Chandrashekhar D; Bodakuntla, Satish; Lahiri, Mayurika; Subhedar, Nishikant K; Kokare, Dadasaheb M

    2016-10-01

    Although cocaine- and amphetamine-regulated transcript peptide (CART) is detected in several cortical and subcortical areas, its role in higher functions has been largely ignored. We examined the significance of CART in memory formation and tested if the downstream actions of CART involve N-methyl-d-aspartate (NMDA) activated extra-cellular signal-regulated kinase (ERK). Newly formed memory was evaluated using novel object recognition test consisting of familiarization (T1) and choice trials (T2). The choice trials were performed at two time points: 30-min (T230-min ) and 24-h (T224-h ) postacquisition. In choice trial (T230-min ), vehicle control rats explored the novel object for significantly longer duration than the familiar object indicating intact memory formation. However, CART-antibody, U0126 [ERK antagonist, both via intracerebroventricular (icv) or intrahippocampal (ih) route] or MK-801 (NMDA antagonist; intraperitoneal) treated rats spent less time exploring novel objects; CART peptide (icv or ih) was ineffective. During choice trial at T224-h , a significant decrease in novel object exploration time was noticed in vehicle control rats suggesting amnesia. However, treatment with CART, prior to familiarization trial (T1), promoted exploration of the novel object even at T224-h . Pretreatment with U0126 or MK-801 blocked pro-cognitive-like effect of CART suggesting involvement of NMDA-ERK pathway in CART's action. Animals subjected to the object familiarization trial showed a drastic increase in the CART-immunoreactivity in the cells of cornu ammonis 3 and polymorph layer of dentate gyrus, and fibers within ento- (ENT) and peri-rhinal (PRH) cortices. Western blot analysis revealed that CART treatment significantly up-regulated the expression of phospo-ERK1/2 in hippocampus, ENT and PRH. This effect was attenuated following pretreatment with U0126 or MK-801, suggesting the activation of ERK signaling cascade through NMDA receptors. Thus, CART system seems

  16. Peripherally injected CCK-8S activates CART positive neurons of the paraventricular nucleus in rats

    Science.gov (United States)

    Noetzel, Steffen; Inhoff, Tobias; Goebel, Miriam; Taché, Yvette; Veh, Rüdiger W.; Bannert, Norbert; Grötzinger, Carsten; Wiedenmann, Bertram; Klapp, Burghard F.; Mönnikes, Hubert; Kobelt, Peter

    2014-01-01

    Cholecystokinin (CCK) plays a role in the short-term inhibition of food intake. Cocaine- and amphetamine-regulated transcript (CART) peptide has been observed in neurons of the paraventricular nucleus (PVN). It has been reported that intracerebroventricular injection of CART peptide inhibits food intake in rodents. The aim of the study was to determine whether intraperitoneally (ip) injected CCK-8S affects neuronal activity of PVN-CART neurons. Ad libitum fed male Sprague-Dawley rats received 6 or 10 μg/kg CCK-8S or 0.15 M NaCl ip (n = 4/group). The number of c-Fos-immunoreactive neurons was determined in the PVN, arcuate nucleus (ARC), and the nucleus of the solitary tract (NTS). CCK-8S dose-dependently increased the number of c-Fos-immunoreactive neurons in the PVN (mean ± SEM: 102 ± 6 vs. 150 ± 5 neurons/section, p < 0.05) and compared to vehicle treated rats (18 ± 7, p < 0.05 vs. 6 and 10 μg/kg CCK-8S). CCK-8S at both doses induced an increase in the number of c-Fos-immunoreactive neurons in the NTS (65 ± 13, p < 0.05, and 182 ± 16, p < 0.05). No effect on the number of c-Fos neurons was observed in the ARC. Immunostaining for CART and c-Fos revealed a dose-dependent increase of activated CART neurons (19 ± 3 vs. 29 ± 7; p < 0.05), only few activated CART neuron were observed in the vehicle group (1 ± 0). The present observation shows that CCK-8S injected ip induces an increase in neuronal activity in PVN-CART neurons and suggests that CART neurons in the PVN may play a role in the mediation of peripheral CCK-8S's anorexigenic effects. PMID:20307613

  17. New developments of the CARTE thermochemical code: I-parameter optimization

    Science.gov (United States)

    Desbiens, N.; Dubois, V.

    We present the calibration of the CARTE thermochemical code that allows to compute the properties of a wide variety of CHON explosives. We have developed an optimization procedure to obtain an accurate multicomponents EOS (fluid phase and condensed phase of carbon). We show here that the results of CARTE code are in good agreement with the specific data of molecular systems and we extensively compare our calculations with measured detonation properties for several explosives.

  18. New developments of the CARTE thermochemical code: I-parameter optimization

    Directory of Open Access Journals (Sweden)

    Dubois V.

    2011-01-01

    Full Text Available We present the calibration of the CARTE thermochemical code that allows to compute the properties of a wide variety of CHON explosives. We have developed an optimization procedure to obtain an accurate multicomponents EOS (fluid phase and condensed phase of carbon. We show here that the results of CARTE code are in good agreement with the specific data of molecular systems and we extensively compare our calculations with measured detonation properties for several explosives.

  19. Expression of Cocaine and Amphetamine Regulated Transcript (CART) in the Porcine Intramural Neurons of Stomach in the Course of Experimentally Induced Diabetes Mellitus.

    Science.gov (United States)

    Bulc, Michał; Gonkowski, Sławomir; Całka, Jarosław

    2015-11-01

    In the present study, the effect of streptozotocin-induced diabetes on the cocaine- and amphetamine-regulated transcript-like immunoreactive (CART-LI) enteric nervous structures was investigated within the porcine stomach. To induce diabetes, the pigs were administered intravenously streptozotocin at a dose of 150 mg/kg of body weight. A significant decrease of the number of CART-LI perikarya was observed in the myenteric plexus of the gastric antrum, corpus, and pylorus in the experimental group. In contrast, submucous plexus was devoid of CART-positive neuronal cells both in control and experimental animals. In the control group, the highest densities of CART-LI nerve fibers were observed in the circular muscle layer of antrum and slightly less nerve fibers were present in the muscle layer of corpus and pylorus. In turn, submucous layer of all studied stomach regions revealed relatively smaller number of CART-positive nerve fibers. Diabetes caused statistically significant decrease in the expression of CART-LI nerve fibers only in the antrum circular muscle layer. Also, no changes in the CART-like immunoreactivity in the intraganglionic nerve fibers were observed. The obtained results suggest that acute hyperglycemia produced significant reduction of the CART expression in enteric perikarya throughout entire stomach as well as decrease of density the CART-LI fibers in circular muscle layer of the antrum. Additionally, we suggest that CART might be involved in the regulation of stomach function especially in the gastric motility.

  20. Reciprocal connections between CART-immunoreactive, hypothalamic paraventricular neurons and serotonergic dorsal raphe cells in the rat: Light microscopic study.

    Science.gov (United States)

    Lee, Ji S; Lee, Hyun S

    2014-04-29

    Based on the overlapping physiological roles of cocaine- and amphetamine-regulated transcript (CART) peptides and serotonin, the present study examined the anatomical connection between the hypothalamic paraventricular nucleus (PVN) and the dorsal raphe (DR). The first series of experiments were performed to investigate descending projections from the CART-immunoreactive (CART-ir) PVN to serotonergic DR cells. CART-ir varicosities made contact with serotonergic DR neurons. An anterograde tracing study revealed that varicosities originating from the PVN formed close appositions to serotonergic neuronal profiles along the entire rostro-caudal extent of the DR. A retrograde study demonstrated that CART neurons projecting to the DR were mainly localized in the caudal parvicellular PVN, comprising approximately 3.0%±0.4% (n=8) of total CART cells. A second series of experiments was performed to investigate ascending projections from the DR to CART-ir PVN cells. Serotonin transporter-ir boutons made contact with CART-ir PVN neurons. Anterograde tracing revealed that varicosities originating from the DR formed close appositions to CART-ir PVN cells. Retrograde examination demonstrated that serotonergic neurons projecting to the parvicellular PVN were located along the entire rostro-caudal extent of the DR. The present observation provided an anatomical basis for accumulating evidence in the literature that suggests a functional interaction between the CART and serotonin systems during the regulation of energy balance, emotional behavior, and arousal.

  1. Cloning and characterization of neuropeptide Y (NPY) and cocaine and amphetamine regulated transcript (CART) in Atlantic cod (Gadus morhua).

    Science.gov (United States)

    Kehoe, Amy S; Volkoff, Hélène

    2007-03-01

    Neuropeptide Y (NPY) and cocaine and amphetamine regulated transcript (CART) are two neuropeptides involved in the regulation of feeding in both mammals and fish. NPY stimulates feeding whereas CART inhibits feeding. In this study, we have cloned the full-length cDNA and complete genomic DNA sequences for NPY and CART in Atlantic cod. Atlantic cod preproNPY share a 45-85% identity with preproNPY from other fish whereas preproCART shows a 70% identity to CART peptides from zebrafish and goldfish. RT-PCR revealed that NPY mRNA is expressed in brain, in particular the forebrain, and in peripheral tissues, including intestine and kidney. CART mRNA is expressed throughout the brain and in ovaries. In order to assess the role of these peptides in the regulation of feeding, we examined changes in mRNA expression in the forebrain before, during and after a meal. NPY and CART mRNA both undergo peri-prandial changes in expression, with NPY levels being elevated around meal time and CART showing a decline 2 h after a meal. Food deprivation for 7 days induced a decrease in CART mRNA expression in the brain but did not affect NPY mRNA expression. Overall, our results suggest that NPY and CART are conserved peptides that might be involved in the regulation of feeding and other physiological functions in Atlantic cod.

  2. Differential distribution and energy status-dependent regulation of the four CART neuropeptide genes in the zebrafish brain.

    Science.gov (United States)

    Akash, G; Kaniganti, Tarun; Tiwari, Neeraj Kumar; Subhedar, Nishikant K; Ghose, Aurnab

    2014-07-01

    The cocaine- and amphetamine-regulated transcript (CART) neuropeptide has been implicated in the neural regulation of energy homeostasis across vertebrate phyla. By using gene-specific in situ hybridization, we have mapped the distribution of the four CART mRNAs in the central nervous system of the adult zebrafish. The widespread neuronal expression pattern for CART 2 and 4 suggests a prominent role for the peptide in processing sensory information from diverse modalities including olfactory and visual inputs. In contrast, CART 1 and 3 have a much more restricted distribution, predominantly located in the nucleus of the medial longitudinal fasciculus (NMLF) and entopeduncular nucleus (EN), respectively. Enrichment of CART 2 and 4 in the preoptic and tuberal areas emphasizes the importance of CART in neuroendocrine functions. Starvation resulted in a significant decrease in CART-positive cells in the nucleus recessus lateralis (NRL) and nucleus lateralis tuberis (NLT) hypothalamic regions, suggesting a function in energy homeostasis for these neurons. Similarly, the EN emerges as a novel energy status-responsive region. Not only is there abundant and overlapping expression of CART 2, 3, and 4 in the EN, but also starvation induced a decrease in CART-expressing neurons in this region. The cellular resolution mapping of CART mRNA and the response of CART-expressing nuclei to starvation underscores the importance of CART neuropeptide in energy processing. Additionally, the regional and gene-specific responses to energy levels suggest a complex, interactive network whereby the four CART gene products may have nonredundant functions in energy homeostasis.

  3. Robust Control Algorithm for a Two Cart System and an Inverted Pendulum

    Science.gov (United States)

    Wilson, Chris L.; Capo-Lugo, Pedro

    2011-01-01

    The Rectilinear Control System can be used to simulate a launch vehicle during liftoff. Several control schemes have been developed that can control different dynamic models of the rectilinear plant. A robust control algorithm was developed that can control a pendulum to maintain an inverted position. A fluid slosh tank will be attached to the pendulum in order to test robustness in the presence of unknown slosh characteristics. The rectilinear plant consists of a DC motor and three carts mounted in series. Each cart s weight can be adjusted with brass masses and the carts can be coupled with springs. The pendulum is mounted on the first cart and an adjustable air damper can be attached to the third cart if desired. Each cart and the pendulum have a quadrature encoder to determine position. Full state feedback was implemented in order to develop the control algorithm along with a state estimator to determine the velocity states of the system. A MATLAB program was used to convert the state space matrices from continuous time to discrete time. This program also used a desired phase margin and damping ratio to determine the feedback gain matrix that would be used in the LabVIEW program. This experiment will allow engineers to gain a better understanding of liquid propellant slosh dynamics, therefore enabling them to develop more robust control algorithms for launch vehicle systems

  4. Advancing monthly streamflow prediction accuracy of CART models using ensemble learning paradigms

    Science.gov (United States)

    Erdal, Halil Ibrahim; Karakurt, Onur

    2013-01-01

    SummaryStreamflow forecasting is one of the most important steps in the water resources planning and management. Ensemble techniques such as bagging, boosting and stacking have gained popularity in hydrological forecasting in the recent years. The study investigates the potential usage of two ensemble learning paradigms (i.e., bagging; stochastic gradient boosting) in building classification and regression trees (CARTs) ensembles to advance the streamflow prediction accuracy. The study, initially, investigates the use of classification and regression trees for monthly streamflow forecasting and employs a support vector regression (SVR) model as the benchmark model. The analytic results indicate that CART outperforms SVR in both training and testing phases. Although the obtained results of CART model in training phase are considerable, it is not in testing phase. Thus, to optimize the prediction accuracy of CART for monthly streamflow forecasting, we incorporate bagging and stochastic gradient boosting which are rooted in same philosophy, advancing the prediction accuracy of weak learners. Comparing with the results of bagged regression trees (BRTs) and stochastic gradient boosted regression trees (GBRTs) models possess satisfactory monthly streamflow forecasting performance than CART and SVR models. Overall, it is found that ensemble learning paradigms can remarkably advance the prediction accuracy of CART models in monthly streamflow forecasting.

  5. Histamine Recycling Is Mediated by CarT, a Carcinine Transporter in Drosophila Photoreceptors.

    Science.gov (United States)

    Xu, Ying; An, Futing; Borycz, Jolanta A; Borycz, Janusz; Meinertzhagen, Ian A; Wang, Tao

    2015-12-01

    Histamine is an important chemical messenger that regulates multiple physiological processes in both vertebrate and invertebrate animals. Even so, how glial cells and neurons recycle histamine remains to be elucidated. Drosophila photoreceptor neurons use histamine as a neurotransmitter, and the released histamine is recycled through neighboring glia, where it is conjugated to β-alanine to form carcinine. However, how carcinine is then returned to the photoreceptor remains unclear. In an mRNA-seq screen for photoreceptor cell-enriched transporters, we identified CG9317, an SLC22 transporter family protein, and named it CarT (Carcinine Transporter). S2 cells that express CarT are able to take up carcinine in vitro. In the compound eye, CarT is exclusively localized to photoreceptor terminals. Null mutations of cart alter the content of histamine and its metabolites. Moreover, null cart mutants are defective in photoreceptor synaptic transmission and lack phototaxis. These findings reveal that CarT is required for histamine recycling at histaminergic photoreceptors and provide evidence for a CarT-dependent neurotransmitter trafficking pathway between glial cells and photoreceptor terminals.

  6. Early regulation of hypothalamic arcuate nucleus CART gene expression by short photoperiod in the Siberian hamster.

    Science.gov (United States)

    Mercer, Julian G; Ellis, Claire; Moar, Kim M; Logie, Tracy J; Morgan, Peter J; Adam, Clare L

    2003-03-28

    Cocaine- and amphetamine-regulated transcript (CART) mRNA is expressed in a number of hypothalamic nuclei including the arcuate nucleus (ARC). An increase in CART gene expression in the ARC of juvenile female Siberian hamsters (Phodopus sungorus) 14 days after transfer to short photoperiod at weaning and prior to major divergence of body weight trajectory in this seasonal mammal implicates CART in the induction of programmed weight change. In the current series of experiments, elevated CART mRNA in short photoperiod juvenile female animals relative to long photoperiod controls was apparent throughout the caudal-rostral extent of the ARC after 14 days, but was not observed when short photoperiod exposure was limited to 4-7 days. Elevated CART gene expression was also observed in juvenile males 14 days after transfer to short photoperiod at weaning, in adult female hamsters 14 days after transfer to short photoperiod and in adult male hamsters 21 days after transfer to short photoperiod. There were no consistent trends in expression levels of other energy balance-related genes with these relatively short duration photoperiod manipulations, suggesting that CART may be involved in short photoperiod-programmed body weight regulation.

  7. Analysis of sequence variability in the CART gene in relation to obesity in a Caucasian population

    Directory of Open Access Journals (Sweden)

    Hercberg Serge

    2005-04-01

    Full Text Available Abstract Background Cocaine and amphetamine regulated transcript (CART is an anorectic neuropeptide located principally in hypothalamus. CART has been shown to be involved in control of feeding behavior, but a direct relationship with obesity has not been established. The aim of this study was to evaluate the effect of polymorphisms within the CART gene with regards to a possible association with obesity in a Caucasian population. Results Screening of the entire gene as well as a 3.7 kb region of 5' upstream sequence revealed 31 SNPs and 3 rare variants ; 14 of which were subsequently genotyped in 292 French morbidly obese subjects and 368 controls. Haplotype analysis suggested an association with obesity which was found to be mainly due to SNP-3608T>C (rs7379701 (p = 0.009. Genotyping additional cases and controls also of European Caucasian origin supported further this possible association between the CART SNP -3608T>C T allele and obesity (global p-value = 0.0005. Functional studies also suggested that the SNP -3608T>C could modulate nuclear protein binding. Conclusion CART SNP -3608T>C may possibly contribute to the genetic risk for obesity in the Caucasian population. However confirmation of the importance of the role of the CART gene in energy homeostasis and obesity will require investigation and replication in further populations.

  8. Statistical techniques for diagnosing CIN using fluorescence spectroscopy: SVD and CART.

    Science.gov (United States)

    Atkinson, E N; Mitchell, M F; Ramanujam, N; Richards-Kortum, R

    1995-01-01

    A quantitative measure of intraepithelial neoplasia which can be made in vivo without tissue removal would be clinically significant in chemoprevention studies. Our group is working to develop such a technique based on fluorescence spectroscopy. Using empirically based algorithms, we have demonstrated that fluorescence is discriminating normal cervix from low- and high-grade cervical dysplasias with similar performance to colposcopy in expert hands. These measurements can be made in vivo, in near real time, and results can be obtained without biopsy. This paper describes a new method using automated analysis of fluorescence emission spectra to classify cervical tissue into multiple diagnostic categories. First, data is reduced using the singular value decomposition (SVD), yielding a set of orthogonal basis vectors. Each patient's emission spectrum is then fit by linear least squares regression to the basis vectors, producing a set of coefficients for each patient. Based on these coefficient values, the classification and regression tree (CART) method predicts the patient's classification. These results suggest that laser-induced fluorescence can be used to automatically recognize and differentially diagnose cervical intraepithelial neoplasia (CIN) at colposcopy. This method of analysis is general in nature, and can analyze fluorescence spectra of suspected intraepithelial neoplasms from other organ sites. As a more complete understanding of the biochemical and morphologic basis of tissue spectroscopy is developed, it may also be possible to use fluorescence spectroscopy of the cervix as a surrogate endpoint biomarker in Phase I and II chemoprevention trials.

  9. To Love—To Live: Barrow and Cart

    Directory of Open Access Journals (Sweden)

    Lisa McDonald

    2013-02-01

    Full Text Available From the residue of meaning, an ensemble of shadows. From the glint of souvenir, pliable impressions. In this paper, we work a poetics of encounter, of being, keeping, homage, of paying homage to fragility, to object and to interspecies—ways are found to engage motion from within and around co-extensive bodies. With the consolation of images, we follow the terse rhythms of routine and street where dwelling is a case of affective dissent. Zones of departure appear through testimony as well as chance, taking their own form. A footfall brings us as observers into quiet spaces which refuse self-estrangement as we travel by way of an unquiet ground. Breath, respiration, aspiration. Precipitation. Sculptures of mist are also the language of lives, of kinship between object, footfall and air. A language of brackets, questions, ellipses. There may be a man, a dog, a barrow. There may be a woman, a cart. Air. How shall this image be made?

  10. CART IV: improving automatic camouflage assessment with assistance methods

    Science.gov (United States)

    Müller, Thomas; Müller, Markus

    2010-04-01

    In order to facilitate systematic, computer aided improvements of camouflage and concealment assessment methods, the software system CART (Camouflage Assessment in Real-Time) was built up for the camouflage assessment of objects in multispectral image sequences (see contributions to SPIE 2007, SPIE 2008 and SPIE 2009 [1], [2], [3]). It comprises a semi-automatic marking of target objects (ground truth generation) including their propagation over the image sequence and the evaluation via user-defined feature extractors. The conspicuity of camouflaged objects due to their movement can be assessed with a purpose-built processing method named MTI snail track algorithm. This paper presents the enhancements over the recent year and addresses procedures to assist the camouflage assessment of moving objects for image data material with strong noise or image artefacts. This extends the evaluation methods significantly to a broader application range. For example, some noisy infrared image data material can be evaluated for the first time by applying the presented methods which fathom the correlations between camouflage assessment, MTI (moving target indication) and dedicated noise filtering.

  11. CART V: recent advancements in computer-aided camouflage assessment

    Science.gov (United States)

    Müller, Thomas; Müller, Markus

    2011-05-01

    In order to facilitate systematic, computer aided improvements of camouflage and concealment assessment methods, the software system CART (Camouflage Assessment in Real-Time) was built up for the camouflage assessment of objects in multispectral image sequences (see contributions to SPIE 2007-2010 [1], [2], [3], [4]). It comprises a semi-automatic marking of target objects (ground truth generation) including their propagation over the image sequence and the evaluation via user-defined feature extractors as well as methods to assess the object's movement conspicuity. In this fifth part in an annual series at the SPIE conference in Orlando, this paper presents the enhancements over the recent year and addresses the camouflage assessment of static and moving objects in multispectral image data that can show noise or image artefacts. The presented methods fathom the correlations between image processing and camouflage assessment. A novel algorithm is presented based on template matching to assess the structural inconspicuity of an object objectively and quantitatively. The results can easily be combined with an MTI (moving target indication) based movement conspicuity assessment function in order to explore the influence of object movement to a camouflage effect in different environments. As the results show, the presented methods contribute to a significant benefit in the field of camouflage assessment.

  12. Intermediate transport in Southeast Asia. [Carts, cycles, mini-buses

    Energy Technology Data Exchange (ETDEWEB)

    Meier, A.K.

    1977-06-01

    Traffic flows through the streets of Southeast Asian countries even though they are used for almost all aspects of human and animal existence. The carts, bicycles, tricycles, and motorcycles, motorized three-wheelers, mini-buses are the so-called intermediate-transport vehicles. It is upon this group of vehicles that a culture--constrained by its own unique economic, environmental, and technological factors--exerts its influence most directly toward the solution of the transport problem. Transportation fills more service roles in Southeast Asian cities than in Western cities. Communication facilities such as telephones and postal services are notoriously unreliable. The personal encounter is all important in social and business interactions in Southeast Asia. Each of the transport modes is examined in view of design and use in a number of specific cultural settings for the countries in Southeast Asia. Present use of intermediate transport in developed countries is discussed briefly, and its further development predicted--pointing out the health and conservation advantages. (MCW)

  13. Failure and Redemption of Multifilter Rotating Shadowband Radiometer (MFRSR/Normal Incidence Multifilter Radiometer (NIMFR Cloud Screening: Contrasting Algorithm Performance at Atmospheric Radiation Measurement (ARM North Slope of Alaska (NSA and Southern Great Plains (SGP Sites

    Directory of Open Access Journals (Sweden)

    James Barnard

    2013-09-01

    Full Text Available Well-known cloud-screening algorithms, which are designed to remove cloud-contaminated aerosol optical depths (AOD from Multifilter Rotating Shadowband Radiometer (MFRSR and Normal Incidence Multifilter Radiometer (NIMFR measurements, have exhibited excellent performance at many middle-to-low latitude sites around world. However, they may occasionally fail under challenging observational conditions, such as when the sun is low (near the horizon and when optically thin clouds with small spatial inhomogeneity occur. Such conditions have been observed quite frequently at the high-latitude Atmospheric Radiation Measurement (ARM North Slope of Alaska (NSA sites. A slightly modified cloud-screening version of the standard algorithm is proposed here with a focus on the ARM-supported MFRSR and NIMFR data. The modified version uses approximately the same techniques as the standard algorithm, but it additionally examines the magnitude of the slant-path line of sight transmittance and eliminates points when the observed magnitude is below a specified threshold. Substantial improvement of the multi-year (1999–2012 aerosol product (AOD and its Angstrom exponent is shown for the NSA sites when the modified version is applied. Moreover, this version reproduces the AOD product at the ARM Southern Great Plains (SGP site, which was originally generated by the standard cloud-screening algorithms. The proposed minor modification is easy to implement and its application to existing and future cloud-screening algorithms can be particularly beneficial for challenging observational conditions.

  14. Southern Great Plains Newsletter

    Energy Technology Data Exchange (ETDEWEB)

    J. Prell

    2010-09-01

    This months issue contains the following articles: (1) Scientists convene at SGP site for complex convective cloud experiment; (2) VORTEX2 spins down; (3) Sunphotometer supports SPARTICUS (a Sun and Aureole Measurement imaging sunphotometer) campaign and satellite validation studies; and (4) Ceilometer represents first deployment of new ground-based instruments from Recovery Act.

  15. CART and Reverse CART Technique in the Retrograde Percutaneous Coronary Intervention of Chronic Total Occlusion%CART和反向CART技术在逆向PCI中的应用

    Institute of Scientific and Technical Information of China (English)

    孙党辉; 李悦

    2011-01-01

    控制性正向-逆向内膜下寻径(CART)和反向CART技术是近年来慢性完全闭塞病变介入治疗重要的技术进展,大大提高了慢性完全闭塞病变经皮冠状动脉介入治疗(PCI)成功率.CART和反向CART技术的开展要求术者具有较丰富的正向PCI操作经验,根据自身技术能力、设备条件和患者病变特点合理选择恰当的PCI治疗技术.在血管内超声指导下反向CART技术的应用进一步提高了手术的成功率和安全性.%CART and reverse CART technique are considered as the important current techniques in percutaneous coronary interven-tion for chronic total occlusion, and have great improved success rates of the recanalization of the chronic total occlusion. IVUS-guided re-verse CART could further elevate the success rate and safety of CTO recanalization. Because of the learning-carve, the operator should per-form antegrade recanalization well first, and choose best way according to the skill of the operator,and the facilities and the lesion condition.

  16. Intra-VTA CART 55-102 reduces the locomotor effect of systemic cocaine in rats: an isobolographic analysis

    OpenAIRE

    Jaworski, Jason N.; Kimmel, Heather L.; Mitrano, Darlene A.; Tallarida, Ronald J.; Kuhar, Michael J

    2007-01-01

    CART (cocaine- and amphetamine-regulated transcript) peptides appear to be mediators or modulators of psychostimulant drugs. An interesting result in the nucleus accumbens has been that injection of CART peptide has no effect by itself on locomotor activity, but it reduces the locomotor activity induced by cocaine or amphetamine. However, in the ventral tegmental area (VTA), injections of CART peptide have been shown to increase locomotor activity, although to a lesser degree (Kimmel et al. 2...

  17. Combined atmospheric radiative transfer (CART) model and its applications%通用大气辐射传输软件(CART)及其应用

    Institute of Scientific and Technical Information of China (English)

    魏合理; 陈秀红; 戴聪明

    2012-01-01

    大气光谱透过率和背景辐射的计算在诸如大气遥感、光电工程等领域有重要应用.根据所提出的中分辨率大气分子吸收快速计算方法、大气气溶胶衰减计算方法、大气多次散射快速算法,研制了一套通用大气辐射传输计算软件(CART),该软件可根据大气参数快速计算可见光到远红外波段的大气光谱透过率和大气背景辐射,光谱分辨率1 cm-1,覆盖可见光到远红外波段.介绍了该软件的计算模型、主要功能和计算实例、部分实际验证结果以及应用领域.CART在目标辐射特性测量的大气修正、光电设备的设计和性能评估将有广泛的应用.%The atmospheric spectral transmittance and background radiance have important applications in many research areas, such as atmospheric remote sensing, optical-electronical engineering, etc. Based on our algorithms of fast computation of atmospheric molecular absorptions, the aerosol extinction, and atmospheric multiple -scattering, a combined atmospheric radiative transfer (CART) software was developed. The CART was used to compute atmospheric spectral transmittance and background radiance from visible to far infrared wavelength range efficiently, the spectral resolution of the CART is 1 cm-1. The algorithms, the computation functions, and some calculating examples of the CART were introduced. Some experimental results for the validation of the CART were also shown. CART could be used in many fields such as atmospheric transmittance correction for target radiative characteristics measurements, the design and performance evaluation of optic-electronic devices, etc.

  18. Blood serum levels of CART peptide in patients with schizophrenia on clozapine monotherapy.

    Science.gov (United States)

    Wysokiński, Adam; Kłoszewska, Iwona

    2014-12-15

    CART (cocaine- and amphetamine-regulated transcript) is an endogenous inhibitor of food intake. We compared fasting serum CART levels in subjects with schizophrenia on clozapine monotherapy (n=24) with sex- and age-matched healthy controls (n=24). CART levels were higher in the clozapine group (262.76±359.91 vs. 90.40±169.90 pg/mL). CART levels were higher in subjects with metabolic syndrome compared to subjects without metabolic syndrome in the clozapine group (415.63±416.93 vs. 122.62±237.17 pg/mL, n=12 and 12, respectively) and in the whole study group (377.73±401.09 vs. 88.58±172.35 pg/mL, n=16 and 32, respectively). In the control group CART levels were higher in subjects with total body fat lower than the target maximum compared to subjects with total body fat below the target maximum (121.71±154.91 vs. 66.32±182.96 pg/mL, n=14 and 10, respectively). CART levels did not correlate with age, weight, BMI, abdominal, waist and hip circumferences, WHR, blood pressure, laboratory tests, clozapine dose, antipsychotic or clozapine treatment duration, body composition, and markers of insulin resistance in the study group. Further studies are required to confirm whether increased levels of circulating CART are compensatory in response to treatment-induced weight gain and abdominal obesity or a primary feature of schizophrenia.

  19. Consistent computation of the age of water parcels using CART

    Science.gov (United States)

    Mercier, Ch.; Delhez, E. J. M.

    The Constituent-oriented Age and Residence time Theory (CART) provides a flexible and efficient framework to diagnose the dynamics of marine systems. Beside the equation for the concentration of appropriate (real or artificial) tracers, the method requires the resolution of differential problems for the so-called age concentration of each of these tracers. Thanks to its Eulerian formulation as an advection/diffusion problem with source terms, the method is easily implemented in existing models. However, some numerical artifacts should be avoided in order to produce physically meaningful results leading to a better understanding of the system under study. In this paper, we address two such issues that are related to the degree of implicitness of the different terms and to the advection scheme. To enforce the consistency between the discrete equations for the concentration of a tracer and for its age concentration, the degree of implicitness must be identical in the source/sink terms of the two equations. However, the ageing term should be computed in a completely explicit (respectively implicit) way if the discretization of the source/sink terms is implicit in time (respectively explicit). A specific attention should also be paid to the advection schemes for the concentration and the age concentration. The raw application of Total Variation Diminishing (TVD) scheme for both equations can lead to the occurrence of artificial local extreme values and spatial oscillations of the age field. While the TVD behavior of the discrete age field cannot be guaranteed, appropriate modifications of the flux/slope limiters used in the TVD schemes can be implemented to enforce a maximum principle that prevents the occurrence of age values outside the physically acceptable range.

  20. Evaluation of Holocene pollen records from the Romanian Plain.

    Science.gov (United States)

    Tomescu

    2000-05-01

    This study is a critical review of pollen analyses carried out on Holocene sequences from 15 sites in and near the Romanian Plain. Three sites come from natural sediments, 10 sites are from anthropogenic deposits and two are from both anthropogenic and natural settings. The general reconstruction is of a steppe-forest-steppe vegetation through the Holocene. The nature of the deposits, however, casts doubts on this reconstruction. Deposits of archaeological sites generally yield pollen spectra that are influenced by human activities and thus unsuitable for vegetation reconstructions. Loess deposits are also unfavorable for pollen preservation because of high pH and porosity. Consequently, pollen spectra from loess deposits are strongly biased by selective pollen destruction. Research and experiments carried out by several authors suggest that spectra dominated by Asteraceae, Poaceae, Chenopodiaceae or Pinus pollen in soils and loess are a result of selective pollen destruction, especially if low pollen concentrations, progressive pollen deterioration or high frequencies of deteriorated or unidentifiable pollen are evidenced. The fact that pollen records from the Romanian Plain come from loess, alkaline peat or archaeological sites reduces their reliability for reconstructions of vegetation. The vegetation history of similar regions in Hungary, Bulgaria and Turkey suggests that early Holocene steppe vegetation was gradually replaced by forest or forest-steppe vegetation in the late Holocene. Records from lake sediments are required to find out whether the Holocene vegetation history of the Romanian Plain was similar.

  1. Saturated thickness, High Plains aquifer, 2009

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This raster data set represents the saturated thickness of the High Plains aquifer of the United States, 2009, in feet. The High Plains aquifer underlies...

  2. Both neuropeptide Y knockdown and Y1 receptor inhibition modulate CART-mediated appetite control.

    Science.gov (United States)

    Chu, Shu-Chen; Chen, Pei-Ni; Ho, Ying-Jui; Yu, Ching-Han; Hsieh, Yih-Shou; Kuo, Dong-Yih

    2015-01-01

    Amphetamine (AMPH)-induced appetite suppression has been attributed to its inhibition of neuropeptide Y (NPY)-containing neurons in the hypothalamus. This study examined whether hypothalamic cocaine- and amphetamine-regulated transcript (CART)-containing neurons and NPY Y1 receptor (Y1R) were involved in the action of AMPH. Rats were treated daily with AMPH for four days, and changes in feeding behavior and expression levels of NPY, CART, and POMC were assessed and compared. The results showed that both feeding behavior and NPY expression decreased during AMPH treatment, with the biggest reduction occurring on Day 2. By contrast, the expression of CART and melanocortin 3 receptor (MC3R), a member of the POMC neurotransmission, increased with the maximum response on Day 2, directly opposite to the NPY expression results. The intracerebroventricular infusion of NPY antisense or Y1R inhibitor both modulated AMPH-induced anorexia and the expression levels of MC3R and CART. The results suggest that in the hypothalamus both POMC- and CART-containing neurons participate in regulating NPY-mediated appetite control during AMPH treatment. These results may advance the knowledge of molecular mechanism of anorectic drugs.

  3. Cancer immunotherapy using CAR-T cells: from the research bench to the assembly line.

    Science.gov (United States)

    Gomes-Silva, Diogo; Ramos, Carlos A

    2017-09-27

    The focus of cancer treatment has recently shifted towards targeted therapies, including immunotherapy, which allow better individualization of care and are hoped to increase the probability of success for patients. Specifically, T cells genetically modified to express chimeric antigen receptors (CARs; CAR-T cells) have generated exciting results. Recent clinical successes with this cutting-edge therapy have helped to push CAR-T cells towards approval for wider use. However, several limitations need to be addressed before the widespread use of CAR-T cells as a standard treatment. Here, we will give a succinct background on adoptive T-cell therapy, followed by a brief overview of the structure of CARs, how they are introduced into T cells, and how CAR-T cell expansion and selection is achieved in vitro. We will discuss some of the challenges in CAR design, as well as the difficulties that arise in large-scale CAR-T cell manufacture that will need to be addressed to achieve successful commercialization of this type of cell therapy. Finally, we will discuss developments already on the horizon. This article is protected by copyright. All rights reserved.

  4. Parallelization of a three-dimensional whole core transport code DeCART

    Energy Technology Data Exchange (ETDEWEB)

    Jin Young, Cho; Han Gyu, Joo; Ha Yong, Kim; Moon-Hee, Chang [Korea Atomic Energy Research Institute, Yuseong-gu, Daejon (Korea, Republic of)

    2003-07-01

    Parallelization of the DeCART (deterministic core analysis based on ray tracing) code is presented that reduces the computational burden of the tremendous computing time and memory required in three-dimensional whole core transport calculations. The parallelization employs the concept of MPI grouping and the MPI/OpenMP mixed scheme as well. Since most of the computing time and memory are used in MOC (method of characteristics) and the multi-group CMFD (coarse mesh finite difference) calculation in DeCART, variables and subroutines related to these two modules are the primary targets for parallelization. Specifically, the ray tracing module was parallelized using a planar domain decomposition scheme and an angular domain decomposition scheme. The parallel performance of the DeCART code is evaluated by solving a rodded variation of the C5G7MOX three dimensional benchmark problem and a simplified three-dimensional SMART PWR core problem. In C5G7MOX problem with 24 CPUs, a speedup of maximum 21 is obtained on an IBM Regatta machine and 22 on a LINUX Cluster in the MOC kernel, which indicates good parallel performance of the DeCART code. In the simplified SMART problem, the memory requirement of about 11 GBytes in the single processor cases reduces to 940 Mbytes with 24 processors, which means that the DeCART code can now solve large core problems with affordable LINUX clusters. (authors)

  5. Active-passive vibration absorber of beam-cart-seesaw system with piezoelectric transducers

    Science.gov (United States)

    Lin, J.; Huang, C. J.; Chang, Julian; Wang, S.-W.

    2010-09-01

    In contrast with fully controllable systems, a super articulated mechanical system (SAMS) is a controlled underactuated mechanical system in which the dimensions of the configuration space exceed the dimensions of the control input space. The objectives of the research are to develop a novel SAMS model which is called beam-cart-seesaw system, and renovate a novel approach for achieving a high performance active-passive piezoelectric vibration absorber for such system. The system consists of two mobile carts, which are coupled via rack and pinion mechanics to two parallel tracks mounted on pneumatic rodless cylinders. One cart carries an elastic beam, and the other cart acts as a counterbalance. One adjustable counterweight mass is also installed underneath the seesaw to serve as a passive damping mechanism to absorb impact and shock energy. The motion and control of a Bernoulli-Euler beam subjected to the modified cart/seesaw system are analyzed first. Moreover, gray relational grade is utilized to investigate the sensitivity of tuning the active proportional-integral-derivative (PID) controller to achieve desired vibration suppression performance. Consequently, it is shown that the active-passive vibration absorber can not only provide passive damping, but can also enhance the active action authority. The proposed software/hardware platform can also be profitable for the standardization of laboratory equipment, as well as for the development of entertainment tools.

  6. Otolaryngology Consult Carts: Maximizing Patient Care, Surgeon Efficiency, and Cost Containment.

    Science.gov (United States)

    Royer, Mark C; Royer, Allison K

    2015-11-01

    The objective of this study was to develop an otolaryngology consult cart system to ensure prompt delivery to the bedside of all the unique equipment and medications required for emergent and urgent otolaryngology consults. An otolaryngology practice responsible for emergency room and hospital consult coverage sought to create a cart containing all equipment, medications, and supplies for otolaryngology consults. Meetings with hospital administration and emergency room, nursing, pharmacy, central processing, and operating room staff were held to develop a system for the emergent delivery of the cart to the needed location, sterilization and restocking of equipment between uses, and appropriate billing of supplies. Two months were required from conception to implementation. All equipment was purchased new, including flexible scopes and headlights. The cart is sterilized, restocked, and maintained by central processing after each use. The equipment is available to handle all airway emergencies as well as all common otolaryngology consults and is delivered bedside in less than 5 minutes. The development of a self-contained otolaryngology consult cart requires coordination with a wide variety of hospital departments. This system, while requiring initial monetary and time investment, has resulted in improved patient care, cost containment, and surgeon convenience. © The Author(s) 2015.

  7. Co-expression patterns of cocaine- and amphetamine-regulated transcript (CART) with neuropeptides in dorsal root ganglia of the pig.

    Science.gov (United States)

    Zacharko-Siembida, Anna; Kulik, Paweł; Szalak, Radosław; Lalak, Roman; Arciszewski, Marcin Bartłomiej

    2014-03-01

    In the present study the neuronal distribution of CART was evaluated immunohistochemically in porcine dorsal root ganglia (DRGs). In co-localization studies the co-expression patterns of CART with SP, CGRP, galanin, CALB and LENK were investigated by means of triple immunohistochemical stainings. In porcine DRGs, the expression of CART was found in approximately 5% of primary sensory neurons. The vast majority (ca. 95%) of CART-immunoreactive (IR) neurons were small and middle sized, and only 5% were categorized as large. CART-IR neurons additionally exhibiting the presence of SP/CGRP (ca. 12%), SP/CALB (ca. 12%), SP/LENK (ca. 5%) were found. The vast majority of CART-IR/CGRP-IR neurons did not display immunoreaction to SP (ca. 60%). Subclasses of CART-IR/LENK-IR/SP-negative (ca. 5%), as well as CART-IR/CALB-IR/SP-negative neurons (ca. 10%), were also visualized. In addition, CART-IR neurons with no immunoreactivities to any of the neuropeptides studied were also shown. In porcine DRGs none of the CART-IR neurons exhibited the presence of galanin. The results obtained in the study suggest that CART may functionally modulate the activity of the porcine primary sensory neurons. It is concluded that co-expression of CART with CGRP, SP, LENK and CALB in subsets of the pig L1-L6 DRGs neurons provide anatomical evidence for a CART role in pain processing.

  8. Neurotransmitter CART as a New Therapeutic Candidate for Parkinson’s Disease

    Directory of Open Access Journals (Sweden)

    Philippe Thuillier

    2013-01-01

    Full Text Available Parkinson’s disease (PD is one of the most common neurodegenerative diseases. To date, there is no effective treatment that halts its progression. Increasing evidence indicates that mitochondria play an important role in the development of PD. Hence mitochondria-targeted approaches or agents may have therapeutic promise for treatment of the disease. Neuropeptide CART (cocaine-amphetamine-regulated transcript, a hypothalamus and midbrain enriched neurotransmitter with an antioxidant property, can be found in mitochondria, which is the main source of reactive oxygen species. Systemic administration of CART has been found to ameliorate dopaminergic neuronal loss and improve motor functions in a mouse model of PD. In this article, we summarize recent progress in studies investigating the relationship between CART, dopamine, and the pathophysiology of PD, with a focus on mitochondria-related topics.

  9. The use of ZIP and CART to model cryptosporidiosis in relation to climatic variables

    Science.gov (United States)

    Hu, Wenbiao; Mengersen, Kerrie; Fu, Shiu-Yun; Tong, Shilu

    2010-07-01

    This research assesses the potential impact of weekly weather variability on the incidence of cryptosporidiosis disease using time series zero-inflated Poisson (ZIP) and classification and regression tree (CART) models. Data on weather variables, notified cryptosporidiosis cases and population size in Brisbane were supplied by the Australian Bureau of Meteorology, Queensland Department of Health, and Australian Bureau of Statistics, respectively. Both time series ZIP and CART models show a clear association between weather variables (maximum temperature, relative humidity, rainfall and wind speed) and cryptosporidiosis disease. The time series CART models indicated that, when weekly maximum temperature exceeded 31°C and relative humidity was less than 63%, the relative risk of cryptosporidiosis rose by 13.64 (expected morbidity: 39.4; 95% confidence interval: 30.9-47.9). These findings may have applications as a decision support tool in planning disease control and risk-management programs for cryptosporidiosis disease.

  10. Golf cart prototype development and navigation simulation using ROS and Gazebo

    Directory of Open Access Journals (Sweden)

    Shimchik Ilya

    2016-01-01

    Full Text Available This paper presents our approach to development of an autonomous golf cart, which will navigate in inaccessible by regular vehicles private areas. For this purpose, we have built a virtual golf course terrain and golf cart model in Gazebo, selected and modernized ROS-based packages in order to use them with Ackermann steering vehicle simulation. To verify our simulation and algorithms, we navigated the golf cart model from one golf hole to another within a virtual 3D golf course. For the real world algorithms’ verification, we developed a small-size vehicle prototype based on Traxxas radio-controlled car model, which is equipped with an on-board controller and sensors. The autonomous navigation of Traxxas-based vehicle prototype has been tested in indoor environment, where it utilized sensory data about environment and vehicle states, and performed localization, optimal trajectory computation and dynamic obstacles’ recognition with adjusting the route in real time.

  11. Classification and regression trees (CART) for estimation of prognosis in patients with gastric carcinoma.

    Science.gov (United States)

    Hermanek, P; Guggenmoos-Holzmann, I

    1994-01-01

    A total of 961 patients who had received resective surgery for gastric carcinoma were grouped according to prognosis by classification and regression trees (CART). This grouping was compared to the present UICC stage grouping. For patients resected for cure (R0) the CART approach allows a better discrimination of patients with poor prognosis (5-year survival rates 15%-30%) from patients with a 5-year survival of 50%, on the one hand, and from patients with extremely poor prognosis (5-year survival rates below 5%) on the other. In the present investigation CART grouping was not influenced by the differentiation between pT1 and pT2 or between pT3 and pT4.

  12. Depletion methodology in the 3-D whole core transport code DeCART

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kang Seog; Cho, Jin Young; Zee, Sung Quun

    2005-02-01

    Three dimensional whole-core transport code DeCART has been developed to include a characteristics of the numerical reactor to replace partly the experiment. This code adopts the deterministic method in simulating the neutron behavior with the least assumption and approximation. This neutronic code is also coupled with the thermal hydraulic code CFD and the thermo mechanical code to simulate the combined effects. Depletion module has been implemented in DeCART code to predict the depleted composition in the fuel. The exponential matrix method of ORIGEN-2 has been used for the depletion calculation. The library of including decay constants, yield matrix and others has been used and greatly simplified for the calculation efficiency. This report summarizes the theoretical backgrounds and includes the verification of the depletion module in DeCART by performing the benchmark calculations.

  13. The use of ZIP and CART to model cryptosporidiosis in relation to climatic variables.

    Science.gov (United States)

    Hu, Wenbiao; Mengersen, Kerrie; Fu, Shiu-Yun; Tong, Shilu

    2010-07-01

    This research assesses the potential impact of weekly weather variability on the incidence of cryptosporidiosis disease using time series zero-inflated Poisson (ZIP) and classification and regression tree (CART) models. Data on weather variables, notified cryptosporidiosis cases and population size in Brisbane were supplied by the Australian Bureau of Meteorology, Queensland Department of Health, and Australian Bureau of Statistics, respectively. Both time series ZIP and CART models show a clear association between weather variables (maximum temperature, relative humidity, rainfall and wind speed) and cryptosporidiosis disease. The time series CART models indicated that, when weekly maximum temperature exceeded 31 degrees C and relative humidity was less than 63%, the relative risk of cryptosporidiosis rose by 13.64 (expected morbidity: 39.4; 95% confidence interval: 30.9-47.9). These findings may have applications as a decision support tool in planning disease control and risk-management programs for cryptosporidiosis disease.

  14. Involvement of oxidative stress in the regulation of NPY/CART-mediated appetite control in amphetamine-treated rats.

    Science.gov (United States)

    Hsieh, Yih-Shou; Chen, Pei-Ni; Yu, Ching-Han; Chen, Chia-Hui; Tsai, Tsung-Ta; Kuo, Dong-Yih

    2015-05-01

    Amphetamine (AMPH) treatment can suppress appetite and increase oxidative stress in the brain. AMPH-induced appetite suppression is associated with the regulation of neuropeptide Y (NPY) and cocaine- and amphetamine-regulated transcript (CART) in the hypothalamus. The present study explored whether antioxidants, including glutathione S-transferase (GST) and glutathione peroxidase (GP), were involved in this NPY/CART-mediated appetite control. Rats were treated daily with AMPH for four days. Changes in food intake and expression levels of hypothalamic NPY, CART, GST, and GP were examined and compared. Results showed that, in AMPH-treated rats, (1) food intake and NPY expression decreased, while CART, GST, and GP expression increased; (2) NPY knockdown in the brain enhanced the decrease in NPY and the increases in CART, GST, and GP expression; and (3) central inhibition of reactive oxygen species production decreased GST and GP and modulated AMPH anorexia and the expression levels of NPY and CART. The present results suggest that oxidative stress in the brain participates in regulating NPY/CART-mediated appetite control in AMPH-treated rats. These results may advance the knowledge regarding the molecular mechanism of AMPH-evoked or NPY/CART-mediated appetite suppression.

  15. Inhibitory modulation of CART peptides in accumbal neuron through decreasing interaction of CaMKIIα with dopamine D3 receptors.

    Science.gov (United States)

    Cai, Zhenyu; Zhang, Dalei; Ying, Ying; Yan, Min; Yang, Jianhua; Xu, Fangyun; Oh, Kiwan; Hu, Zhenzhen

    2014-04-04

    Previous studies in rats have shown that microinjections of cocaine- and amphetamine-regulated transcript (CART) peptide into the nucleus accumbens (NAc; the area of the brain that mediates drug reward and reinforcement) attenuate the locomotor effects of psychostimulants. CART peptide has also been shown to induce decreased intracellular concentrations of calcium (Ca(2+)) in primary cultures of hippocampus neurons. The purpose of this study was to characterize the interaction of Ca(2+)/calmodulin-dependent kinases (CaMKIIα) with dopamine D3 (D3) receptors (R) in primary cultures of accumbal neurons. This interaction is involved in inhibitory modulation of CART peptides. In vitro, CART (55-102) peptide (0.1, 0.5 or 1μM) was found to dose-dependently inhibit K(+) depolarization-elicited Ca(2+) influx and CaMKIIα phosphorylation in accumbal neurons. Moreover, CART peptides were also found to block cocaine (1μM)-induced Ca(2+) influx, CaMKIIα phosphorylation, CaMKIIα-D3R interaction, and CREB phosphorylation. In vivo, repeated microinjections of CART (55-102) peptide (2μg/1μl/side) into the NAc over a 5-day period had no effect on behavioral activity but blocked cocaine-induced locomotor activity. These results indicate that D3R function in accumbal neurons is a target of CART (55-102) peptide and suggest that CART peptide by dephosphorylating limbic D3Rs may have potential as a treatment for cocaine abuse.

  16. Fasting induces CART down-regulation in the zebrafish nervous system in a cannabinoid receptor 1-dependent manner.

    Science.gov (United States)

    Nishio, Shin-Ichi; Gibert, Yann; Berekelya, Liubov; Bernard, Laure; Brunet, Frédéric; Guillot, Etienne; Le Bail, Jean-Christophe; Sánchez, Juan Antonio; Galzin, Anne Marie; Triqueneaux, Gerard; Laudet, Vincent

    2012-08-01

    Central and peripheral mechanisms modulate food intake and energy balance in mammals and the precise role of the type 1 cannabinoid receptor (CB1) in these processes is still being explored. Using the zebrafish, Danio rerio, we show that rimonabant, a CB1-specific antagonist with an EC(50) of 5.15 × 10(-8) m, decreases embryonic yolk sac reserve use. We reveal a developmental overlap between CART genes and CB1 expression in the hypothalamus and medulla oblongata, two brain structures that play crucial roles in appetite regulation in mammals. We show that morpholino knockdown of CB1 or fasting decreases cocaine- and amphetamine-related transcript (CART)-3 expression. Strikingly, this down-regulation occurs only in regions coexpressing CB1 and CART3, reinforcing the link between CB1, CART, and appetite regulation. We show that rimonabant treatment impairs the fasting-induced down-regulation of CART expression in specific brain regions, whereas vehicle alone-treated embryos do not display this rescue of CART expression. Our data reveal that CB1 lies upstream of CART and signals the appetite through the down-regulation of CART expression. Thus, our results establish the zebrafish as a promising system to study appetite regulation.

  17. A combined atmospheric radiative transfer (CART) model and its applications for cirrus clouds simulations

    Science.gov (United States)

    Wei, Heli; Cao, Ya'nan; Chen, Xiuhong

    2012-11-01

    A fast atmospheric radiative transfer model called Combined Atmospheric Radiative Transfer model (CART) has been developed to rapidly calculate atmospheric transmittance and background radiance in the wavenumber range from 1 to 25000 cm-1 with spectral resolution of 1 cm-1. The spectral radiative properties of cirrus clouds at various effective sizes, optical thicknesses, and altitudes from visible to infrared wavelength region are simulated using the CART. The analyses show that the properties of cirrus clouds might be retrieved from the satellite-base spectral characteristics of cirrus clouds based on these simulations.

  18. Tratamiento de los defectos del cartílago articular en la rodilla

    OpenAIRE

    Reverté Vinaixa, María Mercedes

    2015-01-01

    Las lesiones condrales y osteocondrales en la rodilla aparecen en gente joven, activa y con gran expectativa de vida. Estás suponen un gran problema, puesto que este una vez destruido, ya no se repara. Debido a la escasa capacidad intrínseca de curación del cartílago, sus lesiones tienden a causar morbilidad en forma de dolor articular y disfunción. Existen diferentes técnicas quirúrgicas que mejoran la sintomatología y la historia natural de las lesiones condrales. Las lesiones del cartílago...

  19. New developments of the CARTE thermochemical code: Calculation of detonation properties of high explosives

    Science.gov (United States)

    Dubois, Vincent; Desbiens, Nicolas; Auroux, Eric

    2010-07-01

    We present the improvements of the CARTE thermochemical code which provides thermodynamic properties and chemical compositions of CHON systems over a large range of temperature and pressure with a very small computational cost. The detonation products are split in one or two fluid phase (s), treated with the MCRSR equation of state (EOS), and one condensed phase of carbon, modeled with a multiphase EOS which evolves with the chemical composition of the explosives. We have developed a new optimization procedure to obtain an accurate multicomponents EOS. We show here that the results of CARTE code are in good agreement with the specific data of molecular systems and measured detonation properties for several explosives.

  20. CONTROL OF THE DOUBLE INVERTED PENDULUM ON A CART USING THE NATURAL MOTION

    Directory of Open Access Journals (Sweden)

    Zdenek Neusser

    2013-12-01

    Full Text Available This paper deals with controlling the swing-up motion of the double pendulum on a cart using a novel control. The system control is based on finding a feasible trajectory connecting the equilibrium positions from which the eigenfrequencies of the system are determined. Then the system is controlled during the motion between the equilibrium positions by the special harmonic excitation at the system resonances. Around the two equilibrium positions, the trajectory is stabilized by the nonlinear quadratic regulator NQR (also known as SDRE – the State Dependent Riccati Equation. These together form the control between the equilibrium positions demonstrated on the double pendulum on a cart.

  1. Swing-up Menggunakan Energy Contol Method dan Stabilisasi Menggunakan Fuzzy-LQR pada Pendulum Cart System

    Directory of Open Access Journals (Sweden)

    Agus Lesmana

    2014-03-01

    Full Text Available Pendulum Cart System adalah suatu plant yang terdiri dari batang pendulum yang menggantung dan bersumbu pada kedua sisi kereta yang dapat bergerak pada suatu lintasan dengan sumbu vertikal. Pendulum Cart System merupakan salah satu sistem nonlinear yang sering digunakan untuk pengujian berbagai metode kontrol. Makalah ini membahas desain sistem kontrol swing-up dengan menggunakan energy control method. Setelah melakukan swing-up,  Pendulum Cart System distabilkan pada posisi 0 radian dengan menggunakan Fuzzy Linear Quadratic Regulator (LQR. Model nonlinear Pendulum Cart System direpresentasikan dalam model fuzzy Takagi-Sugeno untuk beberapa titik kerja, kemudian kontroler state feedback disusun dengan konsep Parallel Distributed Compensation (PDC menggunakan Linear Quadratic Regulator (LQR. Hasil simulasi serta implementasi menunjukkan bahwa Pendulum Cart System mampu melakukan swing-up dan stabilisasi walaupun diberikan gangguan pada saat stabilisasi.

  2. Plain Polynomial Arithmetic on GPU

    Science.gov (United States)

    Anisul Haque, Sardar; Moreno Maza, Marc

    2012-10-01

    As for serial code on CPUs, parallel code on GPUs for dense polynomial arithmetic relies on a combination of asymptotically fast and plain algorithms. Those are employed for data of large and small size, respectively. Parallelizing both types of algorithms is required in order to achieve peak performances. In this paper, we show that the plain dense polynomial multiplication can be efficiently parallelized on GPUs. Remarkably, it outperforms (highly optimized) FFT-based multiplication up to degree 212 while on CPU the same threshold is usually at 26. We also report on a GPU implementation of the Euclidean Algorithm which is both work-efficient and runs in linear time for input polynomials up to degree 218 thus showing the performance of the GCD algorithm based on systolic arrays.

  3. Intra-VTA CART 55-102 reduces the locomotor effect of systemic cocaine in rats: an isobolographic analysis.

    Science.gov (United States)

    Jaworski, Jason N; Kimmel, Heather L; Mitrano, Darlene A; Tallarida, Ronald J; Kuhar, Michael J

    2007-04-01

    CART (cocaine- and amphetamine-regulated transcript) peptides appear to be mediators or modulators of psychostimulant drugs. An interesting result in the nucleus accumbens has been that injection of CART peptide has no effect by itself on locomotor activity, but it reduces the locomotor activity induced by cocaine or amphetamine. However, in the ventral tegmental area (VTA), injections of CART peptide have been shown to increase locomotor activity, although to a lesser degree [Kimmel, H.L., Gong, W., Vechia, S.D., Hunter, R.G., Kuhar, M.J., 2000. Intra-ventral tegmental area injection of rat cocaine and amphetamine-regulated transcript peptide 55-102 induces locomotor activity and promotes conditioned place preference. J. Pharmacol. Exp. Ther. 294, 784-792]. This study was carried out to clarify the interaction of intra-VTA CART 55-102 and systemic cocaine on locomotor activity. The CART-cocaine interaction has been examined using the rigorous isobolographic approach. This type of analysis permits an assessment of additivity, subadditivity, or synergism of two substances. By measuring locomotor activity and using a range of doses of CART peptide and cocaine, both alone and together, with different dosing strategies, clear evidence of subadditivity was found. CART reduced the locomotor activating effects of systemic cocaine, especially at higher doses of CART. These results imply that intra-VTA CART is not simply acting in the same manner as cocaine, and is likely to oppose the action of cocaine. This has implications for the physiological significance of CART-DA (dopamine) interactions and for medications development.

  4. San Agustin Plains, New Mexico: Age and paleoenvironmental potential reassessed

    Science.gov (United States)

    Markgraf, Vera; Bradbury, J. Platt; Forester, R. M.; Singh, G.; Sternberg, R. S.

    1984-11-01

    Paleomagnetic analysis of samples from the original 600-m-long core from the San Agustin Plains, New Mexico, showed an unquestionable reversal stratigraphy dating the record back to at least 1.6 my. Analysis of pollen, ostracodes, and algae of a duplicate sample section in the vicinity of the original coring site and spanning the last 18,000 yr B.P. shows a much higher resolution than the earlier results.

  5. CART DIAGNOSIS OF WATERSHED IMPAIRMENT IN THE MID-ATLANTIC REGION

    Science.gov (United States)

    Many factors ( stressors ) can lead to increased concentrations of nutrients and sediments, and these factors change across watersheds. Classification and Regression Tree (CART) is a statistical approach that can be used to "diagnose" which factors are important stressors on a pe...

  6. What Works Clearinghouse Quick Review: "A Model for Success: CART's Linked Learning Program Increases College Enrollment"

    Science.gov (United States)

    What Works Clearinghouse, 2012

    2012-01-01

    The study, "A Model for Success: CART's Linked Learning Program Increases College Enrollment" examined whether students who enrolled in courses at a high school that combined academics and technical education had higher college enrollment rates than students who did not. The research described in this report does not meet What Works…

  7. Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

    Science.gov (United States)

    Sotillo, Elena; Barrett, David M.; Black, Kathryn L; Bagashev, Asen; Oldridge, Derek; Wu, Glendon; Sussman, Robyn; Lanauze, Claudia; Ruella, Marco; Gazzara, Matthew R.; Martinez, Nicole M.; Harrington, Colleen T.; Chung, Elaine Y.; Perazzelli, Jessica; Hofmann, Ted J.; Maude, Shannon L.; Raman, Pichai; Barrera, Alejandro; Gill, Saar; Lacey, Simon F.; Melenhorst, Jan J.; Allman, David; Jacoby, Elad; Fry, Terry; Mackall, Crystal; Barash, Yoseph; Lynch, Kristen W.; Maris, John M.; Grupp, Stephan A.; Thomas-Tikhonenko, Andrei

    2015-01-01

    The CD19 antigen, expressed on most B-cell acute lymphoblastic leukemias (B-ALL), can be targeted with chimeric antigen receptor–armed T cells (CART-19), but relapses with epitope loss occur in 10% to 20% of pediatric responders. We detected hemizygous deletions spanning the CD19 locus and de novo frameshift and missense mutations in exon 2 of CD19 in some relapse samples. However, we also discovered alternatively spliced CD19 mRNA species, including one lacking exon 2. Pull-down/siRNA experiments identified SRSF3 as a splicing factor involved in exon 2 retention, and its levels were lower in relapsed B-ALL. Using genome editing, we demonstrated that exon 2 skipping bypasses exon 2 mutations in B-ALL cells and allows expression of the N-terminally truncated CD19 variant, which fails to trigger killing by CART-19 but partly rescues defects associated with CD19 loss. Thus, this mechanism of resistance is based on a combination of deleterious mutations and ensuing selection for alternatively spliced RNA isoforms. Significance CART-19 yield 70% response rates in patients with B-ALL, but also produce escape variants. We discovered that the underlying mechanism is the selection for preexisting alternatively spliced CD19 isoforms with the compromised CART-19 epitope. This mechanism suggests a possibility of targeting alternative CD19 ectodomains, which could improve survival of patients with B-cell neoplasms. PMID:26516065

  8. A bedside food cart as an alternate food service for acute and palliative oncological patients.

    Science.gov (United States)

    Pietersma, Patti; Follett-Bick, Sandra; Wilkinson, Brenda; Guebert, Nancy; Fisher, Kim; Pereira, Jose

    2003-09-01

    Patients with advanced cancer experience various problems with eating, and their meals should be tailored to meet their specific needs. Two methods of food service were compared in a shared acute oncology/palliative care unit; an electrical food cart allowing patients to select their food types and portions at the bedside, and a traditional food tray delivery service that relied on meals being prepared in a centralized kitchen and then delivered by tray. Over a 10-day period, lunch meals were delivered by food cart and supper meals via food trays. Twenty-seven out of 32 patients participated in the trial. Patients significantly preferred the food cart to the trays with respect to the timing and appeal of the meal, appropriateness of food types and food portions and the variety of the food choices. A food cart as used in this trial provides a more flexible and appropriate method of food delivery to in-patients in the oncology and palliative unit. Further studies should examine whether this translates to improved caloric intake and quality of life parameters.

  9. A Rapid Cell Expansion Process for Production of Engineered Autologous CAR-T Cell Therapies.

    Science.gov (United States)

    Lu, Tangying Lily; Pugach, Omar; Somerville, Robert; Rosenberg, Steven A; Kochendefer, James N; Better, Marc; Feldman, Steven A

    2016-12-01

    The treatment of B-cell malignancies by adoptive cell transfer (ACT) of anti-CD19 chimeric antigen receptor T cells (CD19 CAR-T) has proven to be a highly successful therapeutic modality in several clinical trials.(1-6) The anti-CD19 CAR-T cell production method used to support initial trials relied on numerous manual, open process steps, human serum, and 10 days of cell culture to achieve a clinical dose.(7) This approach limited the ability to support large multicenter clinical trials, as well as scale up for commercial cell production. Therefore, studies were completed to streamline and optimize the original National Cancer Institute production process by removing human serum from the process in order to minimize the risk of viral contamination, moving process steps from an open system to functionally closed system operations in order to minimize the risk of microbial contamination, and standardizing additional process steps in order to maximize process consistency. This study reports a procedure for generating CD19 CAR-T cells in 6 days, using a functionally closed manufacturing process and defined, serum-free medium. This method is able to produce CD19 CAR-T cells that are phenotypically and functionally indistinguishable from cells produced for clinical trials by the previously described production process.

  10. Robust Takagi-Sugeno Fuzzy Dynamic Regulator for Trajectory Tracking of a Pendulum-Cart System

    Directory of Open Access Journals (Sweden)

    Miguel A. Llama

    2015-01-01

    Full Text Available Starting from a nonlinear model for a pendulum-cart system, on which viscous friction is considered, a Takagi-Sugeno (T-S fuzzy augmented model (TSFAM as well as a TSFAM with uncertainty (TSFAMwU is proposed. Since the design of a T-S fuzzy controller is based on the T-S fuzzy model of the nonlinear system, then, to address the trajectory tracking problem of the pendulum-cart system, three T-S fuzzy controllers are proposed via parallel distributed compensation: (1 a T-S fuzzy servo controller (TSFSC designed from the TSFAM; (2 a robust TSFSC (RTSFSC designed from the TSFAMwU; and (3 a robust T-S fuzzy dynamic regulator (RTSFDR designed from the RTSFSC with the addition of a T-S fuzzy observer, which estimates cart and pendulum velocities. Both TSFAM and TSFAMwU are comprised of two fuzzy rules and designed via local approximation in fuzzy partition spaces technique. Feedback gains for the three fuzzy controllers are obtained via linear matrix inequalities approach. A swing-up controller is developed to swing the pendulum up from its pendant position to its upright position. Real-time experiments validate the effectiveness of the proposed schemes, keeping the pendulum in its upright position while the cart follows a reference signal, standing out the RTSFDR.

  11. West Valley transfer cart control system design description. Environmental Restoration and Waste Management Program

    Energy Technology Data Exchange (ETDEWEB)

    Bradley, E.C.; Crutcher, R.I.; Halliwell, J.W.; Hileman, M.S.; Moore, M.R.; Nodine, R.N.; Ruppel, F.R.; Vandermolen, R.I.

    1993-01-01

    Detail design of the control system for the West Valley Nuclear Services Vitrification Facility transfer cart has been completed by Oak Ridge National Laboratory. This report documents the requirements and describes the detail design of that equipment and control software. Copies of significant design documents including analysis and testing reports and design drawings are included in the Appendixes.

  12. 蛋鸡下丘脑 CART mRNA序列测定及分析

    Institute of Scientific and Technical Information of China (English)

    于雪静; 庞钰莹; 贺俊平; 李鹏飞; 姜晓龙; 吕丽华

    2013-01-01

      可卡因-苯丙胺调节转录肽(Cocaine-and Amphetamine-Reg ul ated Transcript, CART)对动物繁殖功能有重要调控作用。本试验选用蛋鸡作为研究对象,根据 NCBI 上已登录的各物种的 CART mRNA 序列设计特异性引物,用 RT-PCR 方法从蛋鸡下丘脑内扩增出 CART 部分 CDS 序列并利用 DNAMAN 软件进行分析。结果表明CART 基因在蛋鸡下丘脑内有表达,并获得了230 bp 的序列,为进一步研究蛋鸡产蛋性能奠定基础。

  13. Enterobacteriaceae and related organisms isolated from nest run cart shelves in commercial shell egg processing facilities

    Science.gov (United States)

    Enterobacteriaceae, including Salmonella may be recovered from foods and processing facilities. High levels of Enterobacteriaceae in the processing plant environment can be an indication of inadequate sanitation. This experiment was designed to determine if nest run egg carts serve as reservoirs ...

  14. KLASIFIKASI KARAKTERISTIK KECELAKAAN LALU LINTAS DI KOTA DENPASAR DENGAN PENDEKATAN CLASSIFICATION AND REGRESSION TREES (CART

    Directory of Open Access Journals (Sweden)

    I GEDE AGUS JIWADIANA

    2015-11-01

    Full Text Available The aim of this research is to determine the classification characteristics of traffic accidents in Denpasar city in January-July 2014 by using Classification And Regression Trees (CART. Then, for determine the explanatory variables into the main classifier of CART. The result showed that optimum CART generate three terminal node. First terminal node, there are 12 people were classified as heavy traffic accident characteritics with single accident, and second terminal nodes, there are 68 people were classified as minor traffic accident characteristics by type of traffic accident front-rear, front-front, front-side, pedestrians, side-side and location of traffic accident in district road and sub-district road. For third terminal node, there are 291 people were classified as medium traffic accident characteristics by type of traffic accident front-rear, front-front, front-side, pedestrians, side-side and location of traffic accident in municipality road and explanatory variables into the main splitter to make of CART is type of traffic accident with maximum homogeneity measure of 0.03252.

  15. Demonstration of a Filter Cart for NOx Removal from Ground Support Equipment.

    Science.gov (United States)

    2007-11-02

    emissions. The filter cart was designed to control emissions of NOx, particulate, and unburned hydrocarbons ( UHCs ) from mobile diesel generators. It uses a...rows of activated carbon (AC) filters to adsorb NOx and UHCs . A separate stand-alone system is used to desorb and destroy the contaminants adsorbed

  16. Hydrogeologic framework, hydrology, and refined conceptual model of groundwater flow for Coastal Plain aquifers at the Standard Chlorine of Delaware, Inc. Superfund Site, New Castle County, Delaware, 2005-12

    Science.gov (United States)

    Brayton, Michael J.; Cruz, Roberto M.; Myers, Luke; Degnan, James R.; Raffensperger, Jeff P.

    2015-01-01

    From 1966 to 2002, activities at the Standard Chlorine of Delaware chemical facility in New Castle County, Delaware resulted in the contamination of groundwater, soils, and wetland sediment. In 2005, the U.S. Geological Survey (USGS), in partnership with the U.S. Environmental Protection Agency, Region 3, and the Delaware Department of Natural Resources and Environmental Control began a multi-year investigation of the hydrogeologic framework and hydrology of the confined aquifer system. The goals of the ongoing study at the site (the Potomac Aquifer Study) are to determine the hydraulic connection between the Columbia and Potomac aquifers, determine the direction of groundwater flow in the Potomac aquifer, and identify factors affecting the fate of contaminated groundwater. This report describes progress made towards these goals based on available data collected through September 2012.

  17. The nucleus accumbens 5-HTR₄-CART pathway ties anorexia to hyperactivity.

    Science.gov (United States)

    Jean, A; Laurent, L; Bockaert, J; Charnay, Y; Dusticier, N; Nieoullon, A; Barrot, M; Neve, R; Compan, V

    2012-12-11

    In mental diseases, the brain does not systematically adjust motor activity to feeding. Probably, the most outlined example is the association between hyperactivity and anorexia in Anorexia nervosa. The neural underpinnings of this 'paradox', however, are poorly elucidated. Although anorexia and hyperactivity prevail over self-preservation, both symptoms rarely exist independently, suggesting commonalities in neural pathways, most likely in the reward system. We previously discovered an addictive molecular facet of anorexia, involving production, in the nucleus accumbens (NAc), of the same transcripts stimulated in response to cocaine and amphetamine (CART) upon stimulation of the 5-HT(4) receptors (5-HTR(4)) or MDMA (ecstasy). Here, we tested whether this pathway predisposes not only to anorexia but also to hyperactivity. Following food restriction, mice are expected to overeat. However, selecting hyperactive and addiction-related animal models, we observed that mice lacking 5-HTR(1B) self-imposed food restriction after deprivation and still displayed anorexia and hyperactivity after ecstasy. Decryption of the mechanisms showed a gain-of-function of 5-HTR(4) in the absence of 5-HTR(1B), associated with CART surplus in the NAc and not in other brain areas. NAc-5-HTR(4) overexpression upregulated NAc-CART, provoked anorexia and hyperactivity. NAc-5-HTR(4) knockdown or blockade reduced ecstasy-induced hyperactivity. Finally, NAc-CART knockdown suppressed hyperactivity upon stimulation of the NAc-5-HTR(4). Additionally, inactivating NAc-5-HTR(4) suppressed ecstasy's preference, strengthening the rewarding facet of anorexia. In conclusion, the NAc-5-HTR(4)/CART pathway establishes a 'tight-junction' between anorexia and hyperactivity, suggesting the existence of a primary functional unit susceptible to limit overeating associated with resting following homeostasis rules.

  18. The nucleus accumbens 5-HTR4-CART pathway ties anorexia to hyperactivity

    Science.gov (United States)

    Jean, A; Laurent, L; Bockaert, J; Charnay, Y; Dusticier, N; Nieoullon, A; Barrot, M; Neve, R; Compan, V

    2012-01-01

    In mental diseases, the brain does not systematically adjust motor activity to feeding. Probably, the most outlined example is the association between hyperactivity and anorexia in Anorexia nervosa. The neural underpinnings of this ‘paradox', however, are poorly elucidated. Although anorexia and hyperactivity prevail over self-preservation, both symptoms rarely exist independently, suggesting commonalities in neural pathways, most likely in the reward system. We previously discovered an addictive molecular facet of anorexia, involving production, in the nucleus accumbens (NAc), of the same transcripts stimulated in response to cocaine and amphetamine (CART) upon stimulation of the 5-HT4 receptors (5-HTR4) or MDMA (ecstasy). Here, we tested whether this pathway predisposes not only to anorexia but also to hyperactivity. Following food restriction, mice are expected to overeat. However, selecting hyperactive and addiction-related animal models, we observed that mice lacking 5-HTR1B self-imposed food restriction after deprivation and still displayed anorexia and hyperactivity after ecstasy. Decryption of the mechanisms showed a gain-of-function of 5-HTR4 in the absence of 5-HTR1B, associated with CART surplus in the NAc and not in other brain areas. NAc-5-HTR4 overexpression upregulated NAc-CART, provoked anorexia and hyperactivity. NAc-5-HTR4 knockdown or blockade reduced ecstasy-induced hyperactivity. Finally, NAc-CART knockdown suppressed hyperactivity upon stimulation of the NAc-5-HTR4. Additionally, inactivating NAc-5-HTR4 suppressed ecstasy's preference, strengthening the rewarding facet of anorexia. In conclusion, the NAc-5-HTR4/CART pathway establishes a ‘tight-junction' between anorexia and hyperactivity, suggesting the existence of a primary functional unit susceptible to limit overeating associated with resting following homeostasis rules. PMID:23233022

  19. The importance of viral blips and duration of therapy initiated in primary infection in maintaining viral control after stopping cART

    OpenAIRE

    2014-01-01

    Introduction: After achieving undetectable HIV-RNA on cART, on cessation, HIV-RNA rebounds to pre-treatment values for the majority due to the presence of an inaccessible viral reservoir. There is some evidence that cART during primary HIV infection (PHI) limits the reservoir size, optimizing the chance of maintaining viral control off cART. Data are required to predict possible viral controllers for treatment interruption following cART. This analysis aims to investigate the effect of cART d...

  20. Wide-field diffuse amacrine cells in the monkey retina contain immunoreactive Cocaine- and Amphetamine-Regulated Transcript (CART).

    Science.gov (United States)

    Long, Ye; Bordt, Andrea S; Liu, Weiley S; Davis, Elizabeth P; Lee, Stephen J; Tseng, Luke; Chuang, Alice Z; Whitaker, Christopher M; Massey, Stephen C; Sherman, Michael B; Marshak, David W

    2016-10-01

    The goals of this study were to localize the neuropeptide Cocaine- and Amphetamine-Regulated Transcript (CART) in primate retinas and to describe the morphology, neurotransmitter content and synaptic connections of the neurons that contain it. Using in situ hybridization, light and electron microscopic immunolabeling, CART was localized to GABAergic amacrine cells in baboon retinas. The CART-positive cells had thin, varicose dendrites that gradually descended through the inner plexiform layer and ramified extensively in the innermost stratum. They resembled two types of wide-field diffuse amacrine cells that had been described previously in macaque retinas using the Golgi method and also A17, serotonin-accumulating and waterfall cells of other mammals. The CART-positive cells received synapses from rod bipolar cell axons and made synapses onto the axons in a reciprocal configuration. The CART-positive cells also received synapses from other amacrine cells. Some of these were located on their primary dendrites, and the presynaptic cells there included dopaminergic amacrine cells. Although some CART-positive somas were localized in the ganglion cell layer, they did not contain the ganglion cell marker RNA binding protein with multiple splicing (RBPMS). Based on these results and electrophysiological studies in other mammals, the CART-positive amacrine cells would be expected to play a major role in the primary rod pathway of primates, providing feedback inhibition to rod bipolar cells.

  1. Quantitative and qualitative evaluation of CART-containing cells in adrenal glands of male rats with hypertension.

    Science.gov (United States)

    Kasacka, I; Piotrowska, Ż; Knaś, M; Lewandowska, A

    2014-10-01

    Adrenal activity is stimulated and secretion of stress hormones is increased during advanced stages of renovascular hypertension. The literature suggests that the neuropeptide, cocaine and amphetamine regulated transcript (CART), might regulate adrenal secretory function and thus could influence its activity. We assessed potential quantitative and qualitative changes in the cells that contained CART in the adrenal glands of rats with renovascular hypertension. The renal arteries of ten rats were subjected to a clipping procedure, i.e., two-kidney one-clip (2K1C) model of arterial hypertension, and after 6 weeks each rat developed stable hypertension. CART was localized using immunohistochemistry. CART was detected in a large population of cells in the medulla, sparse nerve fibers in the cortex and the capsule of the adrenal gland. The population of CART-positive cells in adrenal glands of two kidney-one clip (2K1C) treated rats was greater and their immunoreactivity was increased compared to controls. Similarly, the length, width, area and diameter of CART-immunoreactive cells were significantly greater in the hypertensive rats than in controls. We demonstrated that renovascular hypertension alters the number and immunoreactivity of CART-containing cells in adrenal glands.

  2. CART attenuates endoplasmic reticulum stress response induced by cerebral ischemia and reperfusion through upregulating BDNF synthesis and secretion.

    Science.gov (United States)

    Qiu, Bin; Hu, Shengdi; Liu, Libing; Chen, Man; Wang, Lai; Zeng, Xianwei; Zhu, Shigong

    2013-07-12

    Cocaine and amphetamine regulated transcript (CART), a neuropeptide, has shown strong neuroprotective effects against cerebral ischemia and reperfusion (I/R) injury in vivo and in vitro. Here, we report a new effect of CART on ER stress which is induced by cerebral I/R in a rat model of middle cerebral artery occlusion (MCAO) or by oxygen and glucose deprivation (OGD) in cultured cortical neurons, as well as a new functionality of BDNF in the neuroprotection by CART against the ER stress in cerebral I/R. The results showed that CART was effective in reducing the neuronal apoptosis and expression of ER stress markers (GRP78, CHOP and cleaved caspase12), and increasing the BDNF expression in I/R injury rat cortex both in vivo and in vitro. In addition, the effects of CART on ischemia-induced neuronal apoptosis and ER stress were suppressed by tyrosine receptor kinase B (TrkB) IgG, whereas the effects of CART on BDNF transcription, synthesis and secretion were abolished by CREB siRNA. This work suggests that CART is functional in inhibiting the cerebral I/R-induced ER stress and neuronal apoptosis by facilitating the transcription, synthesis and secretion of BDNF in a CREB-dependent way.

  3. The geology of the Madeira Abyssal Plain: further studies relevant to its suitability for radioactive waste disposal

    National Research Council Canada - National Science Library

    Searle, R.C; Williams, S.R.J; Huggett, Q.J; Rothwell, R.G; Schultheiss, P.J; Weaver, P.P.E

    1987-01-01

    .... The history of the selection and investigation of vareious study sites in the North Atlantic is briefly summarised leading to the selection of the Great Meteor East area in the Madeira Abyssal Plain...

  4. Evaluation of CART peptide level in rat plasma and CSF: Possible role as a biomarker in opioid addiction.

    Science.gov (United States)

    Bakhtazad, Atefeh; Vousooghi, Nasim; Garmabi, Behzad; Zarrindast, Mohammad Reza

    2016-10-01

    It has been shown previously that cocaine- and amphetamine-regulated transcript (CART) peptide has a modulatory role and homeostatic regulatory effect in motivation to and reward of the drugs of abuse specially psychostimulants. Recent data also showed that in addition to psychostimulants, CART is critically involved in the different stages of opioid addiction. Here we have evaluated the fluctuations in the level of CART peptide in plasma and CSF in different phases of opioid addiction to find out whether CART can serve as a suitable marker in opioid addiction studies. Male rats were randomly distributed in groups of control, acute low-dose (10mg/kg) morphine, acute high-dose morphine (80mg/kg), chronic escalating doses of morphine, withdrawal syndrome precipitated by administration of naloxone (1mg/kg), and abstinent after long-term drug-free maintenance of addicted animals. The level of CART peptide in CSF and plasma samples was measured by enzyme immunoassay. CART peptide concentration in the CSF and plasma was significantly elevated in acute high-dose morphine and withdrawal state animals and down-regulated in addicted rats. In abstinent group, CART peptide level was up-regulated in plasma but not in CSF samples. As the observed results are in agreement with data regarding the CART mRNA and protein expression in the brain reward pathway in opioid addiction phases, it may be suggested that evaluation of CART peptide level in CSF or plasma could be a suitable marker which reflects the rises and falls of the peptide concentration in brain in the development of opioid addiction.

  5. Holocene delta plain development in the Song Hong (Red River) delta, Vietnam

    Science.gov (United States)

    Funabiki, Ayako; Haruyama, Shigeko; Quy, Nguyen Van; Hai, Pham Van; Thai, Dinh Hung

    2007-05-01

    Holocene delta plain development was investigated based on three sediment cores analyzed in detail from the Song Hong (Red River) delta plain in Vietnam. Two cores (DA and PD) from the western delta plain showed both the landward limit of the transgressive estuarine system in the valley incised during the last glacial maximum and floodplain evolution since the middle Holocene. On the other hand, a core (TL) from the eastern delta plain revealed a Pleistocene terrace buried under the deltaic sediments and a slow accumulation rate compared with that in the west. At 8 cal ky BP, the shoreline migrated very close to the present Hanoi city area, and the sedimentary environment changed to tidal flat or salt marsh. Hanoi city marks the northern limit of shoreline transgression. The mangrove swamp expanded from 8 to 5 cal ky BP to the landward limit of the delta plain. Subsequently, the shoreline migrated seaward as a result of delta progradation and sea-level lowering. From 5 cal ky BP, the emerged area evolved into a floodplain and natural levees formed along the abandoned river channels on the western delta plain, but at 2 cal ky, archeological sites indicate that the Holocene terrace in the eastern delta plain was still inundated.

  6. Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer.

    Science.gov (United States)

    Hege, Kristen M; Bergsland, Emily K; Fisher, George A; Nemunaitis, John J; Warren, Robert S; McArthur, James G; Lin, Andy A; Schlom, Jeffrey; June, Carl H; Sherwin, Stephen A

    2017-01-01

    T cells engineered to express chimeric antigen receptors (CARs) have established efficacy in the treatment of B-cell malignancies, but their relevance in solid tumors remains undefined. Here we report results of the first human trials of CAR-T cells in the treatment of solid tumors performed in the 1990s. Patients with metastatic colorectal cancer (CRC) were treated in two phase 1 trials with first-generation retroviral transduced CAR-T cells targeting tumor-associated glycoprotein (TAG)-72 and including a CD3-zeta intracellular signaling domain (CART72 cells). In trial C-9701 and C-9702, CART72 cells were administered in escalating doses up to 10(10) total cells; in trial C-9701 CART72 cells were administered by intravenous infusion. In trial C-9702, CART72 cells were administered via direct hepatic artery infusion in patients with colorectal liver metastases. In both trials, a brief course of interferon-alpha (IFN-α) was given with each CART72 infusion to upregulate expression of TAG-72. Fourteen patients were enrolled in C-9701 and nine in C-9702. CART72 manufacturing success rate was 100% with an average transduction efficiency of 38%. Ten patients were treated in CC-9701 and 6 in CC-9702. Symptoms consistent with low-grade, cytokine release syndrome were observed in both trials without clear evidence of on target/off tumor toxicity. Detectable, but mostly short-term (≤14 weeks), persistence of CART72 cells was observed in blood; one patient had CART72 cells detectable at 48 weeks. Trafficking to tumor tissues was confirmed in a tumor biopsy from one of three patients. A subset of patients had (111)Indium-labeled CART72 cells injected, and trafficking could be detected to liver, but T cells appeared largely excluded from large metastatic deposits. Tumor biomarkers carcinoembryonic antigen (CEA) and TAG-72 were measured in serum; there was a precipitous decline of TAG-72, but not CEA, in some patients due to induction of an interfering antibody to the TAG

  7. Genome-wide identification of new Wnt/β-catenin target genes in the human genome using CART method

    Directory of Open Access Journals (Sweden)

    Inestrosa Nibaldo C

    2010-06-01

    Full Text Available Abstract Background The importance of in silico predictions for understanding cellular processes is now widely accepted, and a variety of algorithms useful for studying different biological features have been designed. In particular, the prediction of cis regulatory modules in non-coding human genome regions represents a major challenge for understanding gene regulation in several diseases. Recently, studies of the Wnt signaling pathway revealed a connection with neurodegenerative diseases such as Alzheimer's. In this article, we construct a classification tool that uses the transcription factor binding site motifs composition of some gene promoters to identify new Wnt/β-catenin pathway target genes potentially involved in brain diseases. Results In this study, we propose 89 new Wnt/β-catenin pathway target genes predicted in silico by using a method based on multiple Classification and Regression Tree (CART analysis. We used as decision variables the presence of transcription factor binding site motifs in the upstream region of each gene. This prediction was validated by RT-qPCR in a sample of 9 genes. As expected, LEF1, a member of the T-cell factor/lymphoid enhancer-binding factor family (TCF/LEF1, was relevant for the classification algorithm and, remarkably, other factors related directly or indirectly to the inflammatory response and amyloidogenic processes also appeared to be relevant for the classification. Among the 89 new Wnt/β-catenin pathway targets, we found a group expressed in brain tissue that could be involved in diverse responses to neurodegenerative diseases, like Alzheimer's disease (AD. These genes represent new candidates to protect cells against amyloid β toxicity, in agreement with the proposed neuroprotective role of the Wnt signaling pathway. Conclusions Our multiple CART strategy proved to be an effective tool to identify new Wnt/β-catenin pathway targets based on the study of their regulatory regions in the human

  8. Comparison of single and boosted protease inhibitor versus nonnucleoside reverse transcriptase inhibitor-containing cART regimens in antiretroviral-naïve patients starting cART after January 1, 2000

    DEFF Research Database (Denmark)

    Mocroft, A; Horban, A; Clumeck, N;

    2006-01-01

    BACKGROUND: Few published studies have considered both the short- and long-term virologic or immunologic response to combination antiretroviral therapy (cART) and the impact of different cART strategies. PURPOSE: To compare time to initial virologic (200/mm3 cell...... increase) response in antiretroviral-naïve patients starting either a single protease inhibitor (PI; n = 183), a ritonavir-boosted PI regimen (n = 197), or a nonnucleoside reverse transcriptase inhibitor (NNRTI)-based cART regimen (n = 447) after January 1, 2000, and the odds of lack of virologic...... or immunologic response at 3 years after starting cART. METHOD: Cox proportional hazards models and logistic regression. RESULTS: After adjustment, compared to patients taking an NNRTI-regimen, patients taking a single-PI regimen were significantly less likely to achieve a viral load (VL)

  9. Savannah River Region: Transition between the Gulf and Atlantic Coastal Plains. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Zullo, V.A.; Harris, W.B.; Price, V. [eds.

    1990-12-31

    The focus of the this conference of Coastal Plains geologists was on the Savannah River region of Georgia and South Carolina, and particularly on the geology of the US Department of Energy`s 300 square mile Savannah River Site (SRS) in western South Carolina. Current geological studies indicate that the Mesozoic-Cenozoic section in the Savannah River region is transitional between that of the Gulf Coastal Plain to the southwest and that of the Atlantic Coastal Plain to the northeast. With the transitional aspect of the region as its theme, the first session was devoted to overviews of Cretaceous and Paleogene geology in the Gulf and Atlantic Coastal Plains. Succeeding presentations and resulting discussions dealt with more specific problems in structural, lithostratigraphic, hydrological, biostratigraphic, and cyclostratigraphic analysis, and of correlation to standard stratigraphic frameworks. For these conference proceedings, individual papers have been processed separately for the Energy Data Base.

  10. Carpal pseudoerosions: a plain X-ray interpretation pitfall

    Energy Technology Data Exchange (ETDEWEB)

    Wawer, Richard [Univ. Catholique de Lille (France). Service d' Imagerie Medicale; Budzik, Jean Francois [Univ. Catholique de Lille (France). Service d' Imagerie Medicale; Univ. Nord de France, Boulogne sur Mer (France). Unite de Recherche EA 4490, Physiopathologie des Maladies Osseuses Inflammatoires; Demondion, Xavier [Univ. Lille 2 (France). Service d' Imagerie Musculosquelettique; CHRU Lille (France). Lab. d' Anatomie; Forzy, Gerard [Univ. Catholique de Lille, Lomme (France). Lab. de Biologie; Cotten, Anne [Univ. Lille 2 (France). Service d' Imagerie Musculosquelettique; Univ. Nord de France, Boulogne sur Mer (France). Unite de Recherche EA 4490, Physiopathologie des Maladies Osseuses Inflammatoires

    2014-10-15

    To examine in detail images of pseudoerosion of the wrist and hand on plain radiographs. The study was conducted with 28 cadaver wrists. During a single imaging session three techniques - plain radiography, tomosynthesis, and computed tomography - were used to visualize the wrist and hand specimens. For each technique, 20 radio-ulno-carpo-metacarpal sites known to present bone erosions in rheumatoid arthritis were analyzed by two radiologists using a standard system to score the cortical bone: normal, pseudoerosion, true erosion, or other pathology. Cohen's concordance analysis was performed to determine inter-observer and intra-observer (for the senior radiologist) agreement by site and by technique. Serial sections of two cadaver specimens were examined to determine the anatomical correlation of the pseudoerosions. On the plain radiographs, the radiologists scored many images as pseudoerosion (7.3 %), particularly in the distal ulnar portion of the capitate, the distal radial portion of the hamate, the proximal ulnar portion of the base of the third metacarpal, the proximal radial portion of the base of the fourth metacarpal, the distal ulnar portion of the hamate, and the proximal portion of the base of the fifth metacarpal. The computed tomography scan revealed that none of these doubtful images corresponded to true erosions. The anatomical correlation study showed that these images could probably be attributed to ligament insertions, thinner lamina, and enhanced cortical bone transparency. Knowledge of the anatomical carpal localizations where pseudoerosions commonly occur is a necessary prerequisite for analysis of plain radiographs performed to diagnose or monitor rheumatoid arthritis. (orig.)

  11. Chimeric Antigen Receptor T Cells and Hematopoietic Cell Transplantation: How Not to Put the CART Before the Horse.

    Science.gov (United States)

    Kenderian, Saad S; Porter, David L; Gill, Saar

    2017-02-01

    Hematopoietic cell transplantation (HCT) remains an important and potentially curative option for most hematologic malignancies. As a form of immunotherapy, allogeneic HCT (allo-HCT) offers the potential for durable remissions but is limited by transplantation- related morbidity and mortality owing to organ toxicity, infection, and graft-versus-host disease. The recent positive outcomes of chimeric antigen receptor T (CART) cell therapy in B cell malignancies may herald a paradigm shift in the management of these disorders and perhaps other hematologic malignancies as well. Clinical trials are now needed to address the relative roles of CART cells and HCT in the context of transplantation-eligible patients. In this review, we summarize the state of the art of the development of CART cell therapy for leukemia, lymphoma, and myeloma and discuss our perspective of how CART cell therapy can be applied in the context of HCT.

  12. Efficacy and toxicity management of CAR-T cell immunotherapy: A matter of responsiveness control or tumor-specificity?

    DEFF Research Database (Denmark)

    Alonso-Camino, Vanesa; Harwood, Seandean Lykke; Alvarez-Méndez, Ana M;

    2016-01-01

    Chimeric antigen receptor (CAR)-expressing T cells have demonstrated potent clinical efficacy in patients with hematological malignancies. However, the use of CAR-T cells targeting solid tumor-associated antigens (TAAs) has been limited by organ toxicities related to activation of T cell effector...... functions through the CAR. Most existing CARs recognize TAAs, which are also found in normal tissues. CAR-T cell-mediated destruction of normal tissues constitutes a major roadblock to CAR-T cell therapy, and must be avoided or mitigated. There is a broad range of strategies for modulating antigen...... responsiveness of CAR-T cells, with varying degrees of complexity. Some of them might ameliorate the acute and chronic toxicities associated with current CAR constructs. However, further embellishments to CAR therapy may complicate clinical implementation and possibly create new immunogenicity issues...

  13. Selection of Pedaling Load and Design of Electric-Cart Control System with Continuously Adjustable Pedal Load

    Science.gov (United States)

    She, Jin-Hua; Ishii, Shota; Yokota, Sho; Sakuma, Yuji; Ohyama, Yasuhiro

    A previously developed electric cart was improved by installing a knob that allows the driver to continuously vary the pedal load between the strenuous and assisted modes. This paper explains how the pedal load is determined and a design method for the cart control system. First, the largest pedal load is determined from the standpoint of ergonomics on the basis of the rating of perceived exertion and the Karvonen formula with a special focus on the motor function of the elderly. Then, a gain-scheduling cart control system for any pedal load in the allowed range is described, and a stability condition is derived using dynamic parallel distributed compensation. Experimental results demonstrate the validity of the cart control system.

  14. The inhibition of cocaine-induced locomotor activity by CART 55-102 is lost after repeated cocaine administration.

    Science.gov (United States)

    Job, Martin O; Shen, Li L; Kuhar, Michael J

    2013-08-29

    CART peptide is known for having an inhibitory effect on cocaine- and dopamine-mediated actions after acute administration of cocaine and dopamine. In this regard, it is postulated to be a homeostatic, regulatory factor on dopaminergic activity in the nucleus accumbens (NAc). However, there is no data on the effect of CART peptide after chronic administration of cocaine, and this study addresses this. It was found that CART peptide blunted cocaine-induced locomotion (LMA) after acute administration of cocaine, as expected, but it did not affect cocaine-mediated LMA after chronic administration of cocaine. The loss of CART peptide's inhibitory effect did not return for up to 9 weeks after stopping the repeated cocaine administration. It may not be surprising that homeostatic regulatory mechanisms in the NAc are lost after repeated cocaine administration, and that this may be a mechanism in the development of addiction.

  15. Cocaine- and amphetamine-regulated transcript (CART) peptide as an in vivo regulator of cardiac function in Rana ridibunda frog

    National Research Council Canada - National Science Library

    Iliyana V. Ivanova; Rudolf Schubert; Dessislava B. Duridanova; Thomas B. Bolton; Lubomir T. Lubomirov; Hristo S. Gagov

    2007-01-01

    The aim of this study was to investigate the effect of CART peptide on cardiac performance and on the physiological signalling pathways involved using Rana ridibunda frog heart preparations in vivo...

  16. Exit and Paradise Creek Braid Plain Kilometers, 2012

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This dataset consists of points designating braid plain kilometers, or distance along the braid plain centerline, for the 2012 active braid plain of Exit Creek and...

  17. Assessing the HIV Care Continuum in Latin America: progress in clinical retention, cART use and viral suppression

    Directory of Open Access Journals (Sweden)

    Peter F Rebeiro

    2016-04-01

    Full Text Available Introduction: We assessed trends in HIV Care Continuum outcomes associated with delayed disease progression and reduced transmission within a large Latin American cohort over a decade: clinical retention, combination antiretroviral therapy (cART use and viral suppression (VS. Methods: Adults from Caribbean, Central and South America network for HIV epidemiology clinical cohorts in seven countries contributed data between 2003 and 2012. Retention was defined as two or more HIV care visits annually, >90 days apart. cART was defined as prescription of three or more antiretroviral agents annually. VS was defined as HIV-1 RNA <200 copies/mL at last measurement annually. cART and VS denominators were subjects with at least one visit annually. Multivariable modified Poisson regression was used to assess temporal trends and examine associations between age, sex, HIV transmission mode, cohort, calendar year and time in care. Results: Among 18,799 individuals in retention analyses, 14,380 in cART analyses and 13,330 in VS analyses, differences existed between those meeting indicator definitions versus those not by most characteristics. Retention, cART and VS significantly improved from 2003 to 2012 (63 to 77%, 74 to 91% and 53 to 82%, respectively; p<0.05, each. Female sex (risk ratio (RR=0.97 vs. males and injection drug use as HIV transmission mode (RR=0.83 vs. male sexual contact with males (MSM were significantly associated with lower retention, but unrelated with cART or VS. MSM (RR=0.96 significantly decreased the probability of cART compared with heterosexual transmission. Conclusions: HIV Care Continuum outcomes improved over time in Latin America, though disparities for vulnerable groups remain. Efforts must be made to increase retention, cART and VS, while engaging in additional research to sustain progress in these settings.

  18. Region- and sex-specific changes in CART mRNA in rat hypothalamic nuclei induced by forced swim stress.

    Science.gov (United States)

    Balkan, Burcu; Gozen, Oguz; Koylu, Ersin O; Keser, Aysegul; Kuhar, Michael J; Pogun, Sakire

    2012-10-15

    Cocaine and amphetamine regulated transcript (CART) mRNA and peptides are highly expressed in the paraventricular (PVN), dorsomedial (DMH) and arcuate (ARC) nuclei of the hypothalamus. It has been suggested that these nuclei regulate the hypothalamic-pituitary-adrenal (HPA) axis, autonomic nervous system activity, and feeding behavior. Our previous studies showed that forced swim stress augmented CART peptide expression significantly in whole hypothalamus of male rats. In another study, forced swim stress increased the number of CART-immunoreactive cells in female PVN, whereas no effect was observed in male PVN or in the ARC nucleus of either sex. In the present study, we evaluated the effect of forced swim stress on CART mRNA expression in PVN, DMH and ARC nuclei in both male and female rats. Twelve male (stressed and controls, n=6 each) and 12 female (stressed and controls, n=6 each) Sprague-Dawley rats were used. Control animals were only handled, whereas forced swim stress procedure was applied to the stressed groups. Brains were dissected and brain sections containing PVN, DMH and ARC nuclei were prepared. CART mRNA levels were determined by in situ hybridization. In male rats, forced swim stress upregulated CART mRNA expression in DMH and downregulated it in the ARC. In female rats, forced swim stress increased CART mRNA expression in PVN and DMH, whereas a decrease was observed in the ARC nucleus. Our results show that forced swim stress elicits region- and sex-specific changes in CART mRNA expression in rat hypothalamus that may help in explaining some of the effects of stress.

  19. Synergistic effect of CART (cocaine- and amphetamine-regulated transcript peptide and cholecystokinin on food intake regulation in lean mice

    Directory of Open Access Journals (Sweden)

    Kiss Alexander

    2008-10-01

    Full Text Available Abstract Background CART (cocaine- and amphetamine-regulated transcript peptide and cholecystokinin (CCK are neuromodulators involved in feeding behavior. This study is based on previously found synergistic effect of leptin and CCK on food intake and our hypothesis on a co-operation of the CART peptide and CCK in food intake regulation and Fos activation in their common targets, the nucleus tractus solitarii of the brainstem (NTS, the paraventricular nucleus (PVN, and the dorsomedial nucleus (DMH of the hypothalamus. Results In fasted C57BL/6 mice, the anorexigenic effect of CART(61-102 in the doses of 0.1 or 0.5 μg/mouse was significantly enhanced by low doses of CCK-8 of 0.4 or 4 μg/kg, while 1 mg/kg dose of CCK-A receptor antagonist devazepide blocked the effect of CART(61-102 on food intake. After simultaneous administration of 0.1 μg/mouse CART(61-102 and of 4 μg/kg of CCK-8, the number of Fos-positive neurons in NTS, PVN, and DMH was significantly higher than after administration of each particular peptide. Besides, CART(61-102 and CCK-8 showed an additive effect on inhibition of the locomotor activity of mice in an open field test. Conclusion The synergistic and long-lasting effect of the CART peptide and CCK on food intake and their additive effect on Fos immunoreactivity in their common targets suggest a co-operative action of CART peptide and CCK which could be related to synergistic effect of leptin on CCK satiety.

  20. Assessing the HIV Care Continuum in Latin America: progress in clinical retention, cART use and viral suppression

    Science.gov (United States)

    Rebeiro, Peter F; Cesar, Carina; Shepherd, Bryan E; De Boni, Raquel B; Cortés, Claudia P; Rodriguez, Fernanda; Belaunzarán-Zamudio, Pablo; Pape, Jean W; Padgett, Denis; Hoces, Daniel; McGowan, Catherine C; Cahn, Pedro

    2016-01-01

    Introduction We assessed trends in HIV Care Continuum outcomes associated with delayed disease progression and reduced transmission within a large Latin American cohort over a decade: clinical retention, combination antiretroviral therapy (cART) use and viral suppression (VS). Methods Adults from Caribbean, Central and South America network for HIV epidemiology clinical cohorts in seven countries contributed data between 2003 and 2012. Retention was defined as two or more HIV care visits annually, >90 days apart. cART was defined as prescription of three or more antiretroviral agents annually. VS was defined as HIV-1 RNA <200 copies/mL at last measurement annually. cART and VS denominators were subjects with at least one visit annually. Multivariable modified Poisson regression was used to assess temporal trends and examine associations between age, sex, HIV transmission mode, cohort, calendar year and time in care. Results Among 18,799 individuals in retention analyses, 14,380 in cART analyses and 13,330 in VS analyses, differences existed between those meeting indicator definitions versus those not by most characteristics. Retention, cART and VS significantly improved from 2003 to 2012 (63 to 77%, 74 to 91% and 53 to 82%, respectively; p<0.05, each). Female sex (risk ratio (RR)=0.97 vs. males) and injection drug use as HIV transmission mode (RR=0.83 vs. male sexual contact with males (MSM)) were significantly associated with lower retention, but unrelated with cART or VS. MSM (RR=0.96) significantly decreased the probability of cART compared with heterosexual transmission. Conclusions HIV Care Continuum outcomes improved over time in Latin America, though disparities for vulnerable groups remain. Efforts must be made to increase retention, cART and VS, while engaging in additional research to sustain progress in these settings. PMID:27065108

  1. CART modulates beta-amyloid metabolism-associated enzymes and attenuates memory deficits in APP/PS1 mice.

    Science.gov (United States)

    Yin, Kailin; Jin, Jiali; Zhu, Xiaolei; Yu, Linjie; Wang, Sulei; Qian, Lai; Han, Lijuan; Xu, Yun

    2017-10-01

    Cocaine- and amphetamine-regulated transcript (CART) peptide has been demonstrated to exert neuroprotective effects in stroke and some neurodegeneration diseases. In current study, we investigated the protective effects and underlying mechanisms of CART in APP/PS1 mice. The protein levels of CART, soluble Aβ1-40 and Aβ1-42 were measured in the hippocampus of APP/PS1 mice by enzyme-linked immunosorbent assay. We determined the mRNA and protein levels of Aβ metabolism-associated enzymes including neprilysin (NEP), insulin-degrading enzyme (IDE), receptor for advanced glycation end products (RAGE), and low-density lipoprotein receptor-related protein 1 (LRP-1) in the hippocampus of APP/PS1 mice using real-time PCR and western blotting. Spatial memory was measured in APP/PS1 mice using the Morris water maze. The phosphorylation of AKT, ERK, p38, and JNK was determined using western blotting. The levels of soluble Aβ1-40 and Aβ1-42 were significantly decreased in the hippocampus of APP/PS1 mice after CART treatment. CART modulated the levels of NEP, IDE, RAGE, and LRP-1. In addition, CART inhibited the MAPK pathways and activated the AKT pathway, whereas inhibition of the AKT pathway decreased the levels of IDE and LRP-1. Furthermore, CART attenuated spatial memory deficits in the APP/PS1 mice. CART decreases the levels of soluble Aβ in the hippocampus of APP/PS1 mice by modulating the expression of Aβ metabolism-associated enzymes, which may be associated with the MAPK and AKT pathways.

  2. One-dimensional collision carts computer model and its design ideas for productive experiential learning

    CERN Document Server

    Wee, Loo Kang

    2012-01-01

    We develop an Easy Java Simulation (EJS) model for students to experience the physics of idealized one-dimensional collision carts. The physics model is described and simulated by both continuous dynamics and discrete transition during collision. In the field of designing computer simulations, we discuss briefly three pedagogical considerations such as 1) consistent simulation world view with pen paper representation, 2) data table, scientific graphs and symbolic mathematical representations for ease of data collection and multiple representational visualizations and 3) game for simple concept testing that can further support learning. We also suggest using physical world setup to be augmented complimentarily with simulation while highlighting three advantages of real collision carts equipment like tacit 3D experience, random errors in measurement and conceptual significance of conservation of momentum applied to just before and after collision. General feedback from the students has been relatively positive,...

  3. Some perfect cards shuffles (French title: Quelques m\\'elanges parfaits de cartes)

    CERN Document Server

    Lachal, Aimé

    2009-01-01

    In this paper, we study some cards shuffles which are used by magicians. We focus ourselves on the possibility to hit eventually the initial state after several shuffles. This is a classical problem arising in discrete dynamical systems. The computations are performed through an elementary approach, so the paper is easily accessible. ----- Dans cet article, on \\'etudie quelques m\\'elanges de cartes bien connus du monde de la magie. On examine en d\\'etail l'\\'eventualit\\'e de reconstituer le jeu de cartes initial apr\\`es plusieurs m\\'elanges cons\\'ecutifs. Il s'agit math\\'ematiquement d'un probl\\`eme de syst\\`emes dynamiques discrets pour lequel on recherche explicitement une p\\'eriode. Les calculs \\'etant pr\\'esent\\'es de mani\\`ere \\'el\\'ementaire, l'article se veut accessible \\`a un large public.

  4. Demonstration of Launch Vehicle Slosh Instability on Pole-Cart Platform

    Science.gov (United States)

    Pei, Jing; Rothhaar, Paul

    2015-01-01

    Liquid propellant makes up a significant portion of the total weight for large launch vehicles such as Saturn V, Space Shuttle, and the Space Launch System (SLS). Careful attention must be given to the influence of fuel slosh motion on the stability of the vehicle. A well-documented slosh danger zone occurs when the slosh mass is between the vehicle center of mass and the center of percussion. Passive damping via slosh baffle is generally required when the slosh mass is within this region. The pole-cart hardware system, typically used for academic purposes, has similar dynamic characteristics as an unstable launch vehicle. This setup offers a simple and inexpensive way of analyzing slosh dynamics and its impact on flight control design. In this paper, experimental and numerical results from the pole-cart system will be shown and direct analogies to launch vehicle slosh dynamics will be made.

  5. Cervical cancer survival prediction using hybrid of SMOTE, CART and smooth support vector machine

    Science.gov (United States)

    Purnami, S. W.; Khasanah, P. M.; Sumartini, S. H.; Chosuvivatwong, V.; Sriplung, H.

    2016-04-01

    According to the WHO, every two minutes there is one patient who died from cervical cancer. The high mortality rate is due to the lack of awareness of women for early detection. There are several factors that supposedly influence the survival of cervical cancer patients, including age, anemia status, stage, type of treatment, complications and secondary disease. This study wants to classify/predict cervical cancer survival based on those factors. Various classifications methods: classification and regression tree (CART), smooth support vector machine (SSVM), three order spline SSVM (TSSVM) were used. Since the data of cervical cancer are imbalanced, synthetic minority oversampling technique (SMOTE) is used for handling imbalanced dataset. Performances of these methods are evaluated using accuracy, sensitivity and specificity. Results of this study show that balancing data using SMOTE as preprocessing can improve performance of classification. The SMOTE-SSVM method provided better result than SMOTE-TSSVM and SMOTE-CART.

  6. One-dimensional collision carts computer model and its design ideas for productive experiential learning

    Science.gov (United States)

    Wee, Loo Kang

    2012-05-01

    We develop an Easy Java Simulation (EJS) model for students to experience the physics of idealized one-dimensional collision carts. The physics model is described and simulated by both continuous dynamics and discrete transition during collision. In designing the simulations, we discuss briefly three pedagogical considerations namely (1) a consistent simulation world view with a pen and paper representation, (2) a data table, scientific graphs and symbolic mathematical representations for ease of data collection and multiple representational visualizations and (3) a game for simple concept testing that can further support learning. We also suggest using a physical world setup augmented by simulation by highlighting three advantages of real collision carts equipment such as a tacit 3D experience, random errors in measurement and the conceptual significance of conservation of momentum applied to just before and after collision. General feedback from the students has been relatively positive, and we hope teachers will find the simulation useful in their own classes.

  7. Investigation on Superior Performance by Fractional Controller for Cart-Servo Laboratory Set-Up

    Directory of Open Access Journals (Sweden)

    Ameya Anil Kesarkar

    2014-01-01

    Full Text Available In this paper, an investigation is made on the superiority of fractional PID controller (PI^alpha D^beta over conventional PID for the cart-servo laboratory set-up. The designed controllers are optimum in the sense of Integral Absolute Error (IAE and Integral Square Error (ISE. The paper contributes in three aspects: 1 Acquiring nonlinear mathematical model for the cart-servo laboratory set-up, 2 Designing fractional and integer order PID for minimizing IAE, ISE, 3 Analyzing the performance of designed controllers for simulated plant model as well as real plant. The results show a significantly superior performance by PI^alpha D^beta as compared to the conventional PID controller.

  8. On the Stabilization of the Inverted-Cart Pendulum Using the Saturation Function Approach

    OpenAIRE

    2011-01-01

    A simple stabilizing controller for the cart-pendulum system is designed in this paper. Our control strategy describes the underactuated system as a chain of integrators with a high-order smooth nonlinear perturbation and assumes initialization of the system in the upper half plane. The design procedure involves two sequentially associated control actions: one linear and one bounded quasilinear. The first control action brings the nonactuated coordinate near to the upright position and keeps ...

  9. Development of prognostic indicators using Classification And Regression Trees (CART) for survival

    OpenAIRE

    Nunn, Martha E.; Fan, Juanjuan; Su, Xiaogang; McGuire, Michael K.

    2012-01-01

    The development of an accurate prognosis is an integral component of treatment planning in the practice of periodontics. Prior work has evaluated the validity of using various clinical measured parameters for assigning periodontal prognosis as well as for predicting tooth survival and change in clinical conditions over time. We critically review the application of multivariate Classification And Regression Trees (CART) for survival in developing evidence-based periodontal prognostic indicator...

  10. Shopper marketing nutrition interventions: Social norms on grocery carts increase produce spending without increasing shopper budgets☆

    Science.gov (United States)

    Payne, Collin R.; Niculescu, Mihai; Just, David R.; Kelly, Michael P.

    2015-01-01

    Objectives We assessed the efficacy of an easy-to-implement shopper marketing nutrition intervention in a pilot and two additional studies to increase produce demand without decreasing store profitability or increasing shopper budgets. Methods We created grocery cart placards that detailed the number of produce items purchased (i.e., descriptive norm) at particular stores (i.e., provincial norm). The effect of these placards on produce spending was assessed across 971,706 individual person grocery store transactions aggregated by day. The pilot study designated a baseline period (in both control and intervention store) followed by installation of grocery cart placards (in the intervention store) for two weeks. The pilot study was conducted in Texas in 2012. In two additional stores, we designated baseline periods followed by 28 days of the same grocery cart placard intervention as in the pilot. Additional interventions were conducted in New Mexico in 2013. Results The pilot study resulted in a significant difference between average produce spending per day per person across treatment periods (i.e., intervention versus same time period in control) (16%) and the difference between average produce spending per day per person across stores in the control periods (4%); Furthermore, the same intervention in two additional stores resulted in significant produce spending increases of 12.4% and 7.5% per day per person respectively. In all stores, total spending did not change. Conclusions Descriptive and provincial social norm messages (i.e., on grocery cart placards) may be an overlooked tool to increase produce demand without decreasing store profitability and increasing shopper budgets. PMID:26844084

  11. The Vending and à la Carte Policy Intervention in Maine Public High Schools

    Directory of Open Access Journals (Sweden)

    Anne-Marie Davee, MS, RD

    2005-11-01

    Full Text Available Background A healthy school nutrition environment may be important for decreasing childhood overweight. This article describes a project to make healthier snacks and beverages available in vending machines and à la carte programs in Maine public high schools. Context Seven public high schools in Maine volunteered to participate in this project. Four schools made changes to the nutrition environment, and three schools that served as controls did not. The nutrition guidelines were to offer only low-fat (not more than 30% of total calories from fat and low-sugar (not more than 35% by weight of sugar items in vending machines and à la carte programs. Methods Strategies to implement the project included early communications with school officials, monetary stipends for participation, identification of a school liaison, and a committee at each school to promote the healthy changes. Baseline nutrient content and sales of all competitive foods and beverages were assessed to develop the guidelines for changes in the four schools. Student volunteers at all seven schools were measured for height, weight, diet quality, and physical activity level to assess the impact of the change to the nutrition environment. Baseline measures were taken in the spring semester of 2004. Nutrition changes were made to the à la carte programs and vending machines in the four intervention schools at the start of the fall semester of 2004. Follow-up nutrition assessment and student data collection occurred in the spring semester of 2005. Consequences Healthy changes in vending machines were more easily achieved than those made in the à la carte programs. Technical assistance and ongoing support were essential for successful implementation of this intervention. Interpretation It is possible to improve the nutrition environment of Maine public high schools. Stakeholder support is essential to sustain healthy changes.

  12. Energy Shaping Control of an Inverted Flexible Pendulum Fixed to a Cart

    OpenAIRE

    2016-01-01

    Control of compliant mechanical systems is increasingly being researched for several applications including flexible link robots and ultra-precision positioning systems. The control problem in these systems is challenging, especially with gravity coupling and large deformations, because of inherent underactuation and the combination of lumped and distributed parameters of a nonlinear system. In this paper we consider an ultra-flexible inverted pendulum on a cart and propose a new nonlinear en...

  13. Pendekatan Cart untuk Mendapatkan Faktor yang Mempengaruhi Terjangkitnya Penyakit Demam Tifoid di Aceh Utara

    Directory of Open Access Journals (Sweden)

    Dina Yuanita

    2010-05-01

    research conducted to find factors that influence the outbreak of typhoid fever in NAD. research using the CART Method. The results of the analysis indicate that the main factor causing typhoid fever was drinking water reservoirs. The other factors are waste water reservoirs, the physical quality of drinking water, a habit washing hands with soap before eating, the bowel, the dump, gender, socioeconomic status, habits of washing hands with soap after defecation and health education.

  14. L'eau en Franche-Comté: deux cartes pour poser des questions

    Directory of Open Access Journals (Sweden)

    Daniel JOLY

    1993-12-01

    Full Text Available Quatre couches d’information d’une banque de données ont été croisées pour fournir deux cartes prospectives. Elles montrent les zones qui poseront de plus en plus de problèmes pour la qualité de l’eau et les rejets non contrôlés.

  15. The vending and à la carte policy intervention in Maine public high schools.

    Science.gov (United States)

    Davee, Anne-Marie; Blum, Janet E Whatley; Devore, Rachel L; Beaudoin, Christina M; Kaley, Lori A; Leiter, Janet L; Wigand, Debra A

    2005-11-01

    A healthy school nutrition environment may be important for decreasing childhood overweight. This article describes a project to make healthier snacks and beverages available in vending machines and à la carte programs in Maine public high schools. Seven public high schools in Maine volunteered to participate in this project. Four schools made changes to the nutrition environment, and three schools that served as controls did not. The nutrition guidelines were to offer only low-fat (not more than 30% of total calories from fat) and low-sugar (not more than 35% by weight of sugar) items in vending machines and à la carte programs. Strategies to implement the project included early communications with school officials, monetary stipends for participation, identification of a school liaison, and a committee at each school to promote the healthy changes. Baseline nutrient content and sales of all competitive foods and beverages were assessed to develop the guidelines for changes in the four schools. Student volunteers at all seven schools were measured for height, weight, diet quality, and physical activity level to assess the impact of the change to the nutrition environment. Baseline measures were taken in the spring semester of 2004. Nutrition changes were made to the à la carte programs and vending machines in the four intervention schools at the start of the fall semester of 2004. Follow-up nutrition assessment and student data collection occurred in the spring semester of 2005. Healthy changes in vending machines were more easily achieved than those made in the à la carte programs. Technical assistance and ongoing support were essential for successful implementation of this intervention. It is possible to improve the nutrition environment of Maine public high schools. Stakeholder support is essential to sustain healthy changes.

  16. Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies.

    Science.gov (United States)

    Rodgers, David T; Mazagova, Magdalena; Hampton, Eric N; Cao, Yu; Ramadoss, Nitya S; Hardy, Ian R; Schulman, Andrew; Du, Juanjuan; Wang, Feng; Singer, Oded; Ma, Jennifer; Nunez, Vanessa; Shen, Jiayin; Woods, Ashley K; Wright, Timothy M; Schultz, Peter G; Kim, Chan Hyuk; Young, Travis S

    2016-01-26

    Chimeric antigen receptor T (CAR-T) cell therapy has produced impressive results in clinical trials for B-cell malignancies. However, safety concerns related to the inability to control CAR-T cells once infused into the patient remain a significant challenge. Here we report the engineering of recombinant antibody-based bifunctional switches that consist of a tumor antigen-specific Fab molecule engrafted with a peptide neo-epitope, which is bound exclusively by a peptide-specific switchable CAR-T cell (sCAR-T). The switch redirects the activity of the bio-orthogonal sCAR-T cells through the selective formation of immunological synapses, in which the sCAR-T cell, switch, and target cell interact in a structurally defined and temporally controlled manner. Optimized switches specific for CD19 controlled the activity, tissue-homing, cytokine release, and phenotype of sCAR-T cells in a dose-titratable manner in a Nalm-6 xenograft rodent model of B-cell leukemia. The sCAR-T-cell dosing regimen could be tuned to provide efficacy comparable to the corresponding conventional CART-19, but with lower cytokine levels, thereby offering a method of mitigating cytokine release syndrome in clinical translation. Furthermore, we demonstrate that this methodology is readily adaptable to targeting CD20 on cancer cells using the same sCAR-T cell, suggesting that this approach may be broadly applicable to heterogeneous and resistant tumor populations, as well as other liquid and solid tumor antigens.

  17. Registro de los cartógrafos medievales activos en el puerto de Mallorca

    Directory of Open Access Journals (Sweden)

    Llompart, Gabriel

    1997-12-01

    Full Text Available In medieval times, with the opening of the Atlantic trading routes at the beginning of the 14th century, the port of the Ciutat de Mallorques became important as the base of a gathering of both cartographers and copiers of maps. Today these maps are dispersed in museums throughout the world. Until the present day, these early map makers were known only through their works. Presented here is the first register of the "maestros" of navigational charts who worked in the "port of Mallorca". The documentation is taken from local notarial and administrative sources, all of which help the better clarification of their names, birthplaces, their Sitz im Leben and their methods of production, which were later surpassed and improved by the advent of the modern printing press.[fr] Le port de Ciutat de Mallorques fût très important pour l'histoire de la cartographie médiévale, parce-qu'un certain nombre de dessinateurs et copistes de cartes s'établirent là au commencement du XIV siècle, en raison de l'ouverture de la route atlantique. Maintenant, ces cartes se trouvent dispersées en diferents musées par tout le monde. Les auteurs de ces cartes étaient connus et datés jusqu'aujourd'hui à travers ses ouvrages. Dans cet article nous est donné un premier registre des maîtres de cartes de naviguer que travaillèrent au port de Majorque, provenant de sources locales, notariales et administratives, que nous permettent d'eclircir leurs noms, leur date de naissance leur Sitz im Leben et leurs méthodes de travail, peu après débordés et dépassés par la presse moderne.

  18. Monocytes as Regulators of Inflammation and HIV-Related Comorbidities during cART

    OpenAIRE

    Anzinger, Joshua J.; Butterfield, Tiffany R.; Angelovich, Thomas A.; Suzanne M Crowe; PALMER, Clovis S.

    2014-01-01

    Combined antiretroviral therapy (cART) extends the lifespan and the quality of life for HIV-infected persons but does not completely eliminate chronic immune activation and inflammation. The low level of chronic immune activation persisting during cART-treated HIV infection is associated with the development of diseases which usually occur in the elderly. Although T-cell activation has been extensively examined in the context of cART-treated HIV infection, monocyte activation is only beginnin...

  19. Fault detection and diagnosis of induction motors using motor current signature analysis and a hybrid FMM-CART model.

    Science.gov (United States)

    Seera, Manjeevan; Lim, Chee Peng; Ishak, Dahaman; Singh, Harapajan

    2012-01-01

    In this paper, a novel approach to detect and classify comprehensive fault conditions of induction motors using a hybrid fuzzy min-max (FMM) neural network and classification and regression tree (CART) is proposed. The hybrid model, known as FMM-CART, exploits the advantages of both FMM and CART for undertaking data classification and rule extraction problems. A series of real experiments is conducted, whereby the motor current signature analysis method is applied to form a database comprising stator current signatures under different motor conditions. The signal harmonics from the power spectral density are extracted as discriminative input features for fault detection and classification with FMM-CART. A comprehensive list of induction motor fault conditions, viz., broken rotor bars, unbalanced voltages, stator winding faults, and eccentricity problems, has been successfully classified using FMM-CART with good accuracy rates. The results are comparable, if not better, than those reported in the literature. Useful explanatory rules in the form of a decision tree are also elicited from FMM-CART to analyze and understand different fault conditions of induction motors.

  20. Improving safety-restraint use by children in shopping carts: evaluation of a store-based safety intervention.

    Science.gov (United States)

    Smith, Gary A

    2006-08-01

    Approximately 20,700 children who are effectiveness of an in-store intervention to increase the use of restraints in shopping carts by children who are cash coupon incentive. The study used a preintervention and postintervention design with an untreated "control" group. Three stores served as intervention stores, and 4 stores served as nonintervention stores. Trained study personnel conducted the observations unobtrusively in all 7 stores simultaneously, recording the status of children's restraint use in the shopping cart as caregivers approached store checkout areas. The main outcome measure of the study was the change in the proportion of children who were rate increased to 49% in stores with this modest intervention. However, half of the young children in shopping carts remained unrestrained or restrained incorrectly. Higher rates of correct restraint use may occur with a more comprehensive and sustained shopping cart safety intervention. Shopping cart designs that seat children close to the floor and that do not rely on caregiver behavior change and vigilance for injury protection also should be implemented and evaluated as a passive strategy to prevent shopping cart-related injuries to young children.

  1. PLAINS CO2 REDUCTION PARTNERSHIP

    Energy Technology Data Exchange (ETDEWEB)

    Edward N. Steadman; John A. Harju; Erin M. O' Leary; James A. Sorensen; Daniel J. Daly; Melanie D. Jensen; Thea E. Reikoff

    2004-10-01

    The Plains CO{sub 2} Reduction (PCOR) Partnership continues to make great progress. Task 2 (Technology Deployment) focused on developing information regarding deployment issues to support Task 5 (Modeling and Phase II Action Plans) by providing information to be used to assess CO{sub 2} sequestration opportunities in the PCOR Partnership region. Task 3 (Public Outreach) focused on developing an informational video about CO{sub 2} sequestration. Progress in Task 4 (Sources, Sinks, and Infrastructure) included the continued collection of data regarding CO{sub 2} sources and sinks and data on the performance and costs for CO{sub 2} separation, capture, treatment, and compression for pipeline transportation. Task 5 focused on screening and qualitatively assessing sequestration options. Task 5 activities also continue to be useful in structuring data collection and other activities in Tasks 2, 3, and 5.

  2. Planetary plains: subsidence and warping

    Science.gov (United States)

    Kochemasov, G.

    fabric of oceanic floors. Short, medium wave undulations of Pacific's floor (A. Cazenave et al., 1992; D. McAdoo & K. Marks, 1992) present lineations underlining its whole shape. NE lineations predominate on its northern sub-basin, NW lineations on its southern one. They cross at the equatorial zone and together with some other directions give a pattern resembling that observed on the venusian surface. The venusian regional plains typically deformed by wrinkle ridges show interesting similarities to volcanic plains on the Moon and Mars [3]. A subsidence along with warpings can squeeze out some "superfluous" material to surface through planetary scale fissures. This material builds mid-oceanic ridges and huge Hawaii volcano. The Cassini Regio on Iapetus is crossed in the equatorial plain by the dark ridge in some places high 20 km. References: [1] Kochemasov G. G. (2004) Mars and Earth: two dichotomies - one cause. In Workshop on "Hemispheres 1 apart: the origin and modification of the martian crustal dichotomy", LPI Contribution # 1203, Lunar and Planetary Institute, Houston, p. 37. [2] Kochemasov G.G.(1999) Theorems of wave planetary tectonics // Geophys. Res. Abstr. v.1, #3, p.700 . [3] Basilevsky A.T., Head J.W. (2006) Impact craters on regional plains in Venus: Age relations with wrinkle ridges and implications for the geological evolution of Venus // JGR, v.111, EO3006, doi: 10.1029/2005JE002473, 2006. 2

  3. PLAINS CO2 REDUCTION PARTNERSHIP

    Energy Technology Data Exchange (ETDEWEB)

    Edward N. Steadman; John A. Harju; Erin M. O' Leary; James A. Sorensen; Daniel J. Daly; Melanie D. Jensen; Thea E. Reikoff

    2005-01-01

    The Plains CO{sub 2} Reduction (PCOR) Partnership continues to make great progress. Task 2 (Technology Deployment) focused on developing information regarding deployment issues to support Task 5 (Modeling and Phase II Action Plans) by providing information to be used to assess CO{sub 2} sequestration opportunities in the PCOR Partnership region. Task 3 (Public Outreach) focused on developing an informational video about CO{sub 2} sequestration. Progress in Task 4 (Sources, Sinks, and Infrastructure) included the continued collection of data regarding CO{sub 2} sources and sinks and data on the performance and costs for CO{sub 2} separation, capture, treatment, and compression for pipeline transportation. Task 5 focused on screening and qualitatively assessing sequestration options. Task 5 activities also continue to be useful in structuring data collection and other activities in Tasks 2, 3, and 5.

  4. PLAINS CO2 REDUCTION PARTNERSHIP

    Energy Technology Data Exchange (ETDEWEB)

    Edward N. Steadman; John A. Harju; Erin M. O' Leary; James A. Sorensen; Daniel J. Daly; Melanie D. Jensen; Thea E. Reikoff

    2005-01-01

    The Plains CO{sub 2} Reduction (PCOR) Partnership continues to make great progress. Task 2 (Technology Deployment) focused on developing information regarding deployment issues to support Task 5 (Modeling and Phase II Action Plans) by providing information to be used to assess CO{sub 2} sequestration opportunities in the PCOR Partnership region. Task 3 (Public Outreach) focused on developing an informational video about CO{sub 2} sequestration. Progress in Task 4 (Sources, Sinks, and Infrastructure) included the continued collection of data regarding CO{sub 2} sources and sinks and data on the performance and costs for CO{sub 2} separation, capture, treatment, and compression for pipeline transportation. Task 5 focused on screening and qualitatively assessing sequestration options. Task 5 activities also continue to be useful in structuring data collection and other activities in Tasks 2, 3, and 5.

  5. Anthelmintic Resistance of Strongyle Nematodes to Ivermectin and Fenbendazole on Cart Horses in Gondar, Northwest Ethiopia.

    Science.gov (United States)

    Seyoum, Zewdu; Zewdu, Alemu; Dagnachew, Shimelis; Bogale, Basazinew

    2017-01-01

    A study was conducted from November 2015 to April 2016 to determine fenbendazole and ivermectin resistance status of intestinal nematodes of cart horses in Gondar, Northwest Ethiopia. Forty-five strongyle infected animals were used for this study. The animals were randomly allocated into three groups (15 horses per group). Group I was treated with fenbendazole and Group II with ivermectin and Group III was left untreated. Faecal samples were collected from each cart horse before and after treatment. Accordingly, the reduction in the mean fecal egg count at fourteen days of treatment for ivermectin and fenbendazole was 97.25% and 79.4%, respectively. It was significantly different in net egg count between treatment and control groups after treatment. From the study, resistance level was determined for fenbendazole and suspected for ivermectin. In addition, a questionnaire survey was also conducted on 90 selected cart owners to assess their perception on anthelmintics. In the survey, the most available drugs in the study area used by the owners were fenbendazole and ivermectin. Most respondents have no knowledge about drug management techniques. Hence, animal health extension services to create awareness regarding anthelmintic management that plays a key role in reducing the anthelmintic resistance parasites.

  6. Comment ouvrir un compte bancaire et avoir une carte bancaire en France

    Institute of Scientific and Technical Information of China (English)

    应小华

    2011-01-01

    Si vous allez habiter en France pour longtemps,il est nécessaire d'ouvrir un compte bancaire et d'avoir une carte bancaire.Avec la carte bancaire,la consommation devient plus agréable et pratique,et vous n'avez plus besoin de sortir avec beaucoup d'argent.Aujourd'hui,en France,à presque tous les endroits,vous pourriez payer avec une carte bancaire:au restaurant,au supermarché,à la station de métro,et sur Internet,etc.De plus,pour bénéficier d'une aide au logement1 et acheter un forfait portable2 (qui co(u)te généralement moins cher que les appels sans engagement) dont on parlera dans les textes suivants,il vous faut aussi un relevé d'identité bancaire (RIB)3 délivré par votre banque.

  7. HIV-Associated Hodgkin's Lymphoma: Prognosis and Therapy in the Era of cART

    Directory of Open Access Journals (Sweden)

    Caron A. Jacobson

    2012-01-01

    Full Text Available Patients with human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS are at increased risk for developing Hodgkin's lymphoma (HL, a risk that has not decreased despite the success of combination antiretroviral therapy (cART in the modern era. HIV-associated HL (HIV-HL differs from HL in non-HIV-infected patients in that it is nearly always associated with Epstein-Barr virus (EBV and more often presents with high-risk features of advanced disease, systemic “B” symptoms, and extranodal involvement. Before the introduction of cART, patients with HIV-HL had lower response rates and worse outcomes than non-HIV-infected HL patients treated with conventional chemotherapy. The introduction of cART, however, has allowed for the delivery of full-dose and dose-intensive chemotherapy regimens with improved outcomes that approach those seen in non-HIV infected patients. Despite these significant advances, HIV-HL patients remain at increased risk for treatment-related toxicities and drug-drug interactions which require careful attention and supportive care to insure the safe administration of therapy. This paper will address the modern diagnosis, risk stratification, and therapy of HIV-associated HL.

  8. Development of prognostic indicators using Classification And Regression Trees (CART) for survival

    Science.gov (United States)

    Nunn, Martha E.; Fan, Juanjuan; Su, Xiaogang; McGuire, Michael K.

    2014-01-01

    The development of an accurate prognosis is an integral component of treatment planning in the practice of periodontics. Prior work has evaluated the validity of using various clinical measured parameters for assigning periodontal prognosis as well as for predicting tooth survival and change in clinical conditions over time. We critically review the application of multivariate Classification And Regression Trees (CART) for survival in developing evidence-based periodontal prognostic indicators. We focus attention on two distinct methods of multivariate CART for survival: the marginal goodness-of-fit approach, and the multivariate exponential approach. A number of common clinical measures have been found to be significantly associated with tooth loss from periodontal disease, including furcation involvement, probing depth, mobility, crown-to-root ratio, and oral hygiene. However, the inter-relationships among these measures, as well as the relevance of other clinical measures to tooth loss from periodontal disease (such as bruxism, family history of periodontal disease, and overall bone loss), remain less clear. While inferences drawn from any single current study are necessarily limited, the application of new approaches in epidemiologic analyses to periodontal prognosis, such as CART for survival, should yield important insights into our understanding, and treatment, of periodontal diseases. PMID:22133372

  9. A Novel Biped Pattern Generator Based on Extended ZMP and Extended Cart-table Model

    Directory of Open Access Journals (Sweden)

    Guangbin Sun

    2015-07-01

    Full Text Available This paper focuses on planning patterns for biped walking on complex terrains. Two problems are solved: ZMP (zero moment point cannot be used on uneven terrain, and the conventional cart-table model does not allow vertical CM (centre of mass motion. For the ZMP definition problem, we propose the extended ZMP (EZMP concept as an extension of ZMP to uneven terrains. It can be used to judge dynamic balance on universal terrains. We achieve a deeper insight into the connection and difference between ZMP and EZMP by adding different constraints. For the model problem, we extend the cart-table model by using a dynamic constraint instead of constant height constraint, which results in a mathematically symmetric set of three equations. In this way, the vertical motion is enabled and the resultant equations are still linear. Based on the extended ZMP concept and extended cart-table model, a biped pattern generator using triple preview controllers is constructed and implemented simultaneously to three dimensions. Using the proposed pattern generator, the Atlas robot is simulated. The simulation results show the robot can walk stably on rather complex terrains by accurately tracking extended ZMP.

  10. Fuzzy coordinator compensation for balancing control of cart-seesaw system

    Science.gov (United States)

    Lin, J.; Guo, S.-Y.; Chang, Julian

    2011-12-01

    In contrast with fully controllable systems, a super articulated mechanical system (SAMS) is a controlled underactuated mechanical system in which the dimensions of the configuration space exceed the dimensions of the control input space. The control of the cart-seesaw system is especially difficult since it is an underactuated mechanism (three degrees of freedom and only two inputs). This research develops a balancing approach for a novel SAMS model, called the cart-seesaw system, using fuzzy logic and fuzzy coordinator compensation to drive the sliding carts and keep the seesaw angle close to zero in the equilibrium state. Experimental results indicate that utilizing the proposed control methodology significantly enhances the performance. Moreover, the presentation of the fuzzy balancing controller is not considerably affected by changes in the environmental parameters, which demonstrates the effectiveness of the fuzzy controller in minimizing the seesaw tilt angle in the time domain, although the system is caused by unpredicted loading variation. Moreover, the experimental results indicate the usefulness and robustness of the proposed fuzzy control methodology. Furthermore, the proposed software/hardware platform can be beneficial for standardizing laboratory equipment and developing amusement apparatus.

  11. Detection of Neospora sp. antibodies in cart horses from urban areas of Curitiba, Southern Brazil.

    Science.gov (United States)

    Villalobos, Eliana Monteforte Cassaro; Furman, Keiko Endo; Lara, Maria do Carmo Custódio de Souza Hunold; Cunha, Elenice Maria Sequetin; Finger, Mariane Angélica; Busch, Ana Paula Brenner; de Barros Filho, Ivan Roque; Deconto, Ivan; Dornbusch, Peterson Triches; Biondo, Alexander Welker

    2012-01-01

    Neospora caninum is a protozoan parasite which affects dogs as definitive hosts and several mammalian species as intermediate hosts mainly causing abortions and central nervous system disorders. The reemerging population of cart horses for carrying recycling material in urban areas of major cities in Brazil may have an impact on disease spreading, and these animals may be used as sentinels for environmental surveillance. Thus, the present study investigated the frequency of Neospora sp. antibodies in cart horses from Curitiba and surrounding areas, Paraná State, Southern Brazil. IgG antibodies against Neospora sp. were detected using indirect fluorescence antibody test (IFAT), and titers equal to or higher than 1:50 were considered reactive. Of all samples, 14/97 (14.4%) were positive: 2/29 (6.9%) were younger than 5; 5/26 (19.2%) between 6 and 9; and 6/31 (19.4%) older than 10 years of age. One of the 11 animals with unknown age was positive (9.1%). Cart horses are likely to be more exposed to dog feces and to Neospora sp. oocyst contamination in urban settings and a lower frequency of disease in dogs may have a negative impact on horse infection risk in these areas.

  12. Anthelmintic Resistance of Strongyle Nematodes to Ivermectin and Fenbendazole on Cart Horses in Gondar, Northwest Ethiopia

    Directory of Open Access Journals (Sweden)

    Zewdu Seyoum

    2017-01-01

    Full Text Available A study was conducted from November 2015 to April 2016 to determine fenbendazole and ivermectin resistance status of intestinal nematodes of cart horses in Gondar, Northwest Ethiopia. Forty-five strongyle infected animals were used for this study. The animals were randomly allocated into three groups (15 horses per group. Group I was treated with fenbendazole and Group II with ivermectin and Group III was left untreated. Faecal samples were collected from each cart horse before and after treatment. Accordingly, the reduction in the mean fecal egg count at fourteen days of treatment for ivermectin and fenbendazole was 97.25% and 79.4%, respectively. It was significantly different in net egg count between treatment and control groups after treatment. From the study, resistance level was determined for fenbendazole and suspected for ivermectin. In addition, a questionnaire survey was also conducted on 90 selected cart owners to assess their perception on anthelmintics. In the survey, the most available drugs in the study area used by the owners were fenbendazole and ivermectin. Most respondents have no knowledge about drug management techniques. Hence, animal health extension services to create awareness regarding anthelmintic management that plays a key role in reducing the anthelmintic resistance parasites.

  13. Echocardiographic measurement of cart horses in the metropolitan region of Curitiba-PR

    Directory of Open Access Journals (Sweden)

    Amália Turner Giannico

    2015-04-01

    Full Text Available In order to maintain the horses’ performance during the exercise, their hearts adapt to the variations on metabolic activity, resulting in muscular adaptation. Thus, echocardiography allows to assess on both eventual adaptations of heart tissue and impairment of the ability to pump blood. Little is yet known about echocardiography in cart horses, whose general conditions of health and treatment are often inappropriate to the type of exercise they are submitted to. The goal of this study was to establish echocardiographic numbers for cart horses. Nineteen mongrel horses were submitted for echocardiographic examination, and values of the distance from E point (maximum opening mitral valve to the interventricular septum; diameter of left ventricle cavity, interventricular septum thickness and thickness of left ventricle free wall during systole and diastole, fractional shortening and ejection fraction were obtained by M-mode. In the 2D images, diameter of the aortic valve and left atrium were evaluated, and their relationship. The velocities of the blood flow were evaluated in aorta and pulmonary artery and the mitral valve by means of Doppler, and possible insufficiency was detected through the color Doppler. Mean values for echocardiographic parameters were established considering 19 traction horses that worked pulling cart loads. There were no significant values that indicated either an inappropriate cardiac remodeling, a left ventricular dysfunction – with consequent decrease in exercises performance – or diseases that affect the animal’s performance at work.

  14. Automated Cart with VIS/NIR Hyperspectral Reflectance and Fluorescence Imaging Capabilities

    Directory of Open Access Journals (Sweden)

    Alan M. Lefcourt

    2016-12-01

    Full Text Available A system to take high-resolution Visible/Near Infra-Red (VIS/NIR hyperspectral reflectance and fluorescence images in outdoor fields using ambient lighting or a pulsed laser (355 nm, respectively, for illumination purposes was designed, built, and tested. Components of the system include a semi-autonomous cart, a gated-intensified camera, a spectral adapter, a frequency-triple Nd:YAG (Neodymium-doped Yttrium Aluminium Garnet laser, and optics to convert the Gaussian laser beam into a line-illumination source. The front wheels of the cart are independently powered by stepper motors that support stepping or continuous motion. When stepping, a spreadsheet is used to program parameters of image sets to be acquired at each step. For example, the spreadsheet can be used to set delays before the start of image acquisitions, acquisition times, and laser attenuation. One possible use of this functionality would be to establish acquisition parameters to facilitate the measurement of fluorescence decay-curve characteristics. The laser and camera are mounted on an aluminum plate that allows the optics to be calibrated in a laboratory setting and then moved to the cart. The system was validated by acquiring images of fluorescence responses of spinach leaves and dairy manure.

  15. The importance of viral blips and duration of therapy initiated in primary infection in maintaining viral control after stopping cART

    Science.gov (United States)

    Fidler, Sarah; Olson, Ashley; Fox, Julie; Phillips, Andrew; Morrison, Charles; Thornhill, John; Bucher, Heiner; Muga, Roberto; Porter, Kholoud

    2014-01-01

    Introduction After achieving undetectable HIV-RNA on cART, on cessation, HIV-RNA rebounds to pre-treatment values for the majority due to the presence of an inaccessible viral reservoir. There is some evidence that cART during primary HIV infection (PHI) limits the reservoir size, optimizing the chance of maintaining viral control off cART. Data are required to predict possible viral controllers for treatment interruption following cART. This analysis aims to investigate the effect of cART duration and the rate of viral blips while on cART initiated in PHI, and other factors on maintaining viral control for those stopping cART. Material and Methods Using CASCADE data on HIV seroconverters, we characterized virologic blip (viral suppression on cART followed by a single HIV-RNA above a blip threshold and a subsequent measure below the threshold without cART change) rates for those starting cART within six months of seroconversion (SC). Using Cox models, we examined the effect of the following factors on time to virologic rebound (HIV-RNA>1000) after cART stop: cART duration, severity/rate of blips on cART, time from SC to cART start, cART class, SC year, SC age, CD4 at cART start/stop, sex and HIV risk group. Results The 660 individuals initiating cART in PHI were mostly male (91%), seroconverting between 1995 and 2012, with a median (IQR) age of 34 (29, 41) years mostly infected through sex between men (73%). Median cART duration was 14.8 (7.0, 31.7) months initiated at a median 1.9 (0.5, 3.9) months post SC. 13 (11, 16), 9 (7, 11), 6 (5, 9) and 7 (6, 10)% of individuals experienced blips >50, 100, 200 and 400 copies/mL, respectively. Of those who experienced blips, most (77–90%, depending on blip threshold) experienced just one. Among 250 individuals with undetectable HIV-RNA at cART stop, median time to rebound was 1.6 (0.30, 5.8) months. Time on cART was the only factor independently associated with control after stopping, HR for rebound=0.91 (0.86, 0.98) per

  16. GIS and Landscape Analysis, or the cart before the horse?

    Directory of Open Access Journals (Sweden)

    Caroline Phillips

    2004-11-01

    Full Text Available Spatial analysis has traditionally considered settlements in relation to each other and aspects of topography. Criticisms of environmental determinism, and identification of problems with site data and analytical models, have followed. Transferring spatial analysis to a GIS platform has not resolved these concerns. This article highlights the fact that there are cultural assumptions within spatial analyses, through examining the land-use systems practised by New Zealand Māori, and argues that models based on modern European land use are not necessarily appropriate for other times and cultures. This test case also supports the contextual archaeology definition of landscape as a dynamic inclusive system between people and land. It is concluded that the resolution of such problems, especially when analysing societies with a recent ethnography or history, requires a landscape approach together with multi-disciplinary data and the further development of dynamic modelling and simulation through GIS.

  17. Whillans Ice Plain Stick Slip

    Science.gov (United States)

    Lipovsky, B.; Dunham, E. M.

    2015-12-01

    Concern about future sea level rise motivates the study of fast flowing ice. The Whillans Ice Plain (WIP) region of the West Antarctic Ice Sheet is notable for decelerating from previously fast motion during the instrumental record. Since most ice flux in Antarctica occurs through ice streams, understanding the conditions that cause ice stream stagnation is of basic importance in understanding the continent's contribution to future sea level rise. Although recent progress has been made in understanding the relationship between basal conditions and ice stream motion, direct observation of the temporal variation in subglacial conditions during ice stream stagnation has remained elusive. The Whillans Ice Plain flows to the sea mostly by way of stick-slip motion. We present numerical simulations of this stick-slip motion that capture the inertial dynamics, seismic waves, and the evolution of sliding with rate- and state-dependent basal friction. Large scale stick-slip behavior is tidally modulated and encompasses the entire WIP. Sliding initiates within one of several locked regions and then propagates outward with low average rupture velocity (~ 200 m/s). Sliding accelerates over a period of 200 s attain values as large as 65 m/d. From Newton's second law, this acceleration is ~ T / (rho H) for average shear stress drop T, ice thickness H, and ice density rho. This implies a 3 Pa stress drop that must be reconciled with the final stress drop of 300 Pa inferred from the total slip and fault dimensions. A possible explanation of this apparent discrepancy is that deceleration of the ice is associated with a substantial decrease in traction within rate-strengthening regions of the bed. During these large-scale sliding events, m-scale patches at the bed produce rapid (20 Hz) stick-slip motion. Each small event occurs over ~ 1/100 s, produces ~ 40 microns of slip, and gives rise to a spectacular form of seismic tremor. Variation between successive tremor episodes allows us

  18. Integration of stress and leptin signaling by CART producing neurons in the rodent midbrain centrally projecting Edinger-Westphal nucleus.

    Science.gov (United States)

    Xu, Lu; Janssen, Donny; van der Knaap, Noortje; Roubos, Eric W; Leshan, Rebecca L; Myers, Martin G; Gaszner, Balázs; Kozicz, Tamás

    2014-01-01

    Leptin targets the brain to regulate feeding, neuroendocrine function and metabolism. The leptin receptor is present in hypothalamic centers controlling energy metabolism as well as in the centrally projecting Edinger-Westphal nucleus (EWcp), a region implicated in the stress response and in various aspects of stress-related behaviors. We hypothesized that the stress response by cocaine- and amphetamine-regulated transcript (CART)-producing EWcp-neurons would depend on the animal's energy state. To test this hypothesis, we investigated the effects of changes in energy state (mimicked by low, normal and high leptin levels, which were achieved by 24 h fasting, normal chow and leptin injection, respectively) on the response of CART neurons in the EWcp of rats subjected or not to acute restraint stress. Our data show that leptin treatment alone significantly increases CART mRNA expression in the rat EWcp and that in leptin receptor deficient (db/db) mice, the number of CART producing neurons in this nucleus is reduced. This suggests that leptin has a stimulatory effect on the production of CART in the EWcp under non-stressed condition. Under stressed condition, however, leptin blunts stress-induced activation of EWcp neurons and decreases their CART mRNA expression. Interestingly, fasting, does not influence the stress-induced activation of EWcp-neurons, and specifically EWcp-CART neurons are not activated. These results suggest that the stress response by the EWcp depends to some degree on the animal's energy state, a mechanism that may contribute to a better understanding of the complex interplay between obesity and stress.

  19. Integration of stress and leptin signaling by CART producing neurons in the rodent midbrain centrally projecting Edinger-Westphal nucleus

    Directory of Open Access Journals (Sweden)

    Lu eXu

    2014-03-01

    Full Text Available Leptin targets the brain to regulate feeding, neuroendocrine function and metabolism. The leptin receptor is present in hypothalamic centers controlling energy metabolism as well as in the centrally projecting Edinger-Westphal nucleus (EWcp, a region implicated in the stress response and in various aspects of stress-related behaviors. We hypothesized that the stress response by cocaine- and amphetamine-regulated transcript (CART-producing EWcp-neurons would depend on the animal’s energy state. To test this hypothesis, we investigated the effects of changes in energy state (mimicked by low, normal and high leptin levels, which were achieved by 24h fasting, normal chow and leptin injection, respectively on the response of CART neurons in the EWcp of rats subjected or not to acute restraint stress. Our data show that leptin treatment alone significantly increases CART mRNA expression in the rat EWcp and that in leptin receptor deficient (db/db mice, the number of CART producing neurons in this nucleus is reduced. This suggests that leptin has a stimulatory effect on the production of CART in the EWcp under non-stressed condition. Under stressed condition, however, leptin blunts stress-induced activation of EWcp neurons and decreases their CART mRNA expression. Interestingly, fasting, does not influence the stress-induced activation of EWcp-neurons, and specifically EWcp-CART neurons are not activated. These results suggest that the stress response by the EWcp depends to some degree on the animal’s energy state, a mechanism that may contribute to a better understanding of the complex interplay between obesity and stress.

  20. Lack of viral control and development of cART escape mutations in macaques after bone marrow transplantation

    Science.gov (United States)

    PETERSON, Christopher W.; HAWORTH, Kevin G.; POLACINO, Patricia; HUANG, Meei-Li; SYKES, Craig; OBENZA, Willimark M.; REPETTO, Andrea C.; KASHUBA, Angela; BUMGARNER, Roger; DeROSA, Stephen C.; WOOLFREY, Ann E.; JEROME, Keith R.; MULLINS, James I.; HU, Shiu-Lok; KIEM, Hans-Peter

    2015-01-01

    Objective We have previously demonstrated robust control of simian/human immunodeficiency virus (SHIV1157-ipd3N4) viremia following administration of combination antiretroviral therapy (cART) in pigtailed macaques. Here, we sought to determine the safety of hematopoietic stem cell transplantation (HSCT) in cART-suppressed and unsuppressed animals. Design We compared disease progression in animals challenged with SHIV 100 days post-transplant (PT), to controls that underwent transplant following SHIV challenge and stable, cART-dependent viral suppression. Methods SHIV viral load, combination antiretroviral therapy (cART) levels, and anti-SHIV antibodies were measured longitudinally from plasma/serum from each animal. Flow cytometry was used to assess T-cell subset frequencies in peripheral blood and gastrointestinal tract (GI). Deep sequencing was used to identify cART resistance mutations. Results In control animals, virus challenge induced transient peak viremia, viral set point, and durable suppression by cART. Subsequent HSCT was not associated with adverse events in these animals. PT animals were challenged during acute recovery following HSCT, and displayed sustained peak viremia and cART resistance. Although PT animals had comparable plasma levels of antiretroviral drugs and showed no evidence of enhanced infection of myeloid subsets in the periphery, they exhibited a drastic reduction in virus-specific antibody production and decreased T-cell counts. Conclusions These results suggest that virus challenge prior to complete transplant recovery impairs viral control and may promote drug resistance. These findings may also have implications for scheduled treatment interruption (STI) studies in patients on cART during post-HSCT recovery: premature STI could similarly result in lack of viral control and cART resistance. PMID:26372270

  1. A New Insight into the Role of CART in Cocaine Reward: Involvement of CaMKII and Inhibitory G-Protein Coupled Receptor Signaling

    Directory of Open Access Journals (Sweden)

    ChengPeng Yu

    2017-08-01

    Full Text Available Cocaine- and amphetamine-regulated transcript (CART peptides are neuropeptides that are expressed in brain regions associated with reward, such as the nucleus accumbens (NAc, and play a role in cocaine reward. Injection of CART into the NAc can inhibit the behavioral effects of cocaine, and injecting CART into the ventral tegmental area (VTA reduces cocaine-seeking behavior. However, the exact mechanism of these effects is not clear. Recent research has demonstrated that Ca2+/calmodulin-dependent protein kinase II (CaMKII and inhibitory G-protein coupled receptor (GPCR signaling are involved in the mechanism of the effect of CART on cocaine reward. Hence, we review the role of CaMKII and inhibitory GPCR signaling in the effect of CART on cocaine reward and provide a new insight into the mechanism of that effect. In this article, we will first review the biological function of CART and discuss the role of CART in cocaine reward. Then, we will focus on the role of CaMKII and inhibitory GPCR signaling in cocaine reward. Furthermore, we will discuss how CaMKII and inhibitory GPCR signaling are involved in the mechanistic action of CART in cocaine reward. Finally, we will provide our opinions regarding the future directions of research on the role of CaMKII and inhibitory GPCR signaling in the effect of CART on cocaine reward.

  2. 44 CFR 10.14 - Flood plains and wetlands.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Flood plains and wetlands. 10... Flood plains and wetlands. For any action taken by FEMA in a flood plain or wetland, the provisions of... Executive Order 11988, Flood Plain Management, and Executive Order 11990, Protection of Wetlands (44...

  3. PLAINS CO2 REDUCTION PARTNERSHIP

    Energy Technology Data Exchange (ETDEWEB)

    Edward N. Steadman; John A. Harju; Erin M. O' Leary; James A. Sorensen; Daniel J. Daly; Melanie D. Jensen; Lisa S. Botnen

    2005-07-01

    The Plains CO{sub 2} Reduction (PCOR) Partnership characterization work is nearing completion, and most remaining efforts are related to finalizing work products. Task 2 (Technology Deployment) has developed a Topical Report entitled ''Deployment Issues Related to Geologic CO{sub 2} Sequestration in the PCOR Partnership Region''. Task 3 (Public Outreach) has developed an informational Public Television program entitled ''Nature in the Balance'', about CO{sub 2} sequestration. The program was completed and aired on Prairie Public Television in this quarter. Task 4 (Sources, Sinks, and Infrastructure) efforts are nearing completion, and data regarding CO{sub 2} sources and sinks and data on the performance and costs for CO{sub 2} separation, capture, treatment, and compression for pipeline transportation are being incorporated into a series of topical reports. The expansion of the Decision Support System Geographic Information System database has continued with the development of a ''save bookmark'' feature that allows users to save a map from the system easily. A feature that allows users to develop a report that summarizes CO{sub 2} sequestration parameters was also developed. Task 5 (Modeling and Phase II Action Plans) focused on screening and qualitatively assessing sequestration options and developing economic estimates for important regional CO{sub 2} sequestration strategies.

  4. PLAINS CO2 REDUCTION PARTNERSHIP

    Energy Technology Data Exchange (ETDEWEB)

    Edward N. Steadman; John A. Harju; Erin M. O' Leary; James A. Sorensen; Daniel J. Daly; Melanie D. Jensen; Thea E. Reikoff

    2005-04-01

    The Plains CO{sub 2} Reduction (PCOR) Partnership continues to make great progress. Task 2 (Technology Deployment) focused on developing information regarding deployment issues to support Task 5 (Modeling and Phase II Action Plans) and provided information to be used to assess CO{sub 2} sequestration opportunities in the PCOR Partnership region. Task 2 efforts also included preparation of a draft topical report entitled ''Deployment Issues Related to Geologic CO{sub 2} Sequestration in the PCOR Partnership Region'', which is nearing completion. Task 3 (Public Outreach) focused on developing an informational video about CO{sub 2} sequestration. The video will be completed and aired on Prairie Public Television in the next quarter. Progress in Task 4 (Sources, Sinks, and Infrastructure) included the continued collection of data regarding CO{sub 2} sources and sinks and data on the performance and costs for CO{sub 2} separation, capture, treatment, and compression for pipeline transportation. The addition of the Canadian province of Alberta to the PCOR Partnership region expanded the decision support system (DSS) geographic information system database. Task 5 screened and qualitatively assessed sequestration options. Task 5 activities also continue to be useful in structuring data collection and other activities in Tasks 2, 3, and 5.

  5. Towards groundwater neutral cropping systems in the Alluvial Fans of the North China Plain

    NARCIS (Netherlands)

    Oort, van P.A.J.; Wang, G.; Vos, J.; Meinke, H.; Li, B.G.; Huang, J.K.; Werf, van der W.

    2016-01-01

    Groundwater levels in the North China Plain (NCP), the bread basket of China, have dropped more than one meter per year over the last 40 years, putting at risk the long term productivity of this region. Groundwater decline is most severe in the Alluvial Fans where our study site is located.

  6. Dating fluvial archives of the Riverine Plain, Southeastern Australia

    Science.gov (United States)

    Mueller, Daniela; Cohen, Tim; Reinfelds, Ivars; Jacobs, Zenobia; Shulmeister, James

    2016-04-01

    The Riverine Plain of Southeastern Australia is characterized by a multiplicity of relict river channels. Compared to the modern drainage system the most prominent of those distinct features are defined by large bankfull channel widths, large meander wavelengths and coarse sediment loads. Such morphological differences provide evidence for regimes of higher discharge, stemming from significant changes in runoff volumes, flood-frequency regimes and sediment supply. An existing geochronology for some of these channels is based on multi-grain thermoluminescence (Murrumbidgee River; Page et al., 1996) or radio-carbon dating (Goulburn River; Bowler, 1978) and indicates enhanced fluvial activity between 30 to 13 ka. The absence of exact Last Glacial Maximum (LGM, 21 ± 3 ka) ages of the Murrumbidgee palaeochannels was interpreted to indicate decreased fluvial activity during the peak of the LGM but was not inferred for the nearby Goulburn River. Recent developments in optical dating, especially measurements of individual grains of quartz, allow for an examination of these previous findings. Key sites along the Murrumbidgee and Goulburn Rivers have been revisited and new sites of the adjacent Murray River have been investigated. A revised, high-resolution geochronology based on single-grain optically stimulated luminescence dating is used to examine the precise occurrence of those massive channels and their implications for the Southern Hemisphere LGM. References: Page, K., Nanson, G., Price, D. (1996). Chronology of Murrumbidgee River palaeochannels on the Riverine Plain, southeastern Australia. Journal of Quaternary Science 11(4): 311-326. Bowler, J. (1978). Quaternary Climate and Tectonics in the Evolution of the Riverine Plain, Southeastern Australia. In: Davies, J. & Williams, M. (Editors). Landform Evolution in Australia, Australian National University Press: Canberra. p. 70-112.

  7. Psychosocial factors affecting medication adherence among HIV-1 infected adults receiving combination antiretroviral therapy (cART) in Botswana.

    Science.gov (United States)

    Do, Natalie T; Phiri, Kelesitse; Bussmann, Hermann; Gaolathe, Tendani; Marlink, Richard G; Wester, C William

    2010-06-01

    As increasing numbers of persons are placed on potentially life-saving combination antiretroviral therapy (cART) in sub-Saharan Africa, it is imperative to identify the psychosocial and social factors that may influence antiretroviral (ARV) medication adherence. Using an 87 question survey, the following data were collected from patients on cART in Botswana: demographics, performance (Karnofsky) score, perceived stigma and level of HIV disclosure, attitudes and beliefs concerning HIV/AIDS, substance and/or drug use, depression, and pharmacy and healthcare provider-related factors. Overall adherence rates were determined by patient self-report, institutional adherence, and a culturally modified Morisky scale. Three hundred adult patients were recruited between April and May 2005. The overall cART adherence rate was 81.3% based on 4 day and 1 month patient recall and on clinic attendance for ARV medication refills during the previous 3 months. Adults receiving cART for 1-6 months were the least adherent (77%) followed by those receiving cART for greater than 12 months (79%). Alcohol use, depression, and nondisclosure of positive HIV status to their partner were predictive of poor adherence rates (p value HIV disclosure to "at-risk" partners and provide ongoing counseling and education to help patients recognize and overcome HIV-associated stigma, alcohol abuse, and depression.

  8. Liver Fibrosis in HIV Patients Receiving a Modern cART

    Science.gov (United States)

    Mohr, Raphael; Schierwagen, Robert; Schwarze-Zander, Carolynne; Boesecke, Christoph; Wasmuth, Jan-Christian; Trebicka, Jonel; Rockstroh, Jürgen Kurt

    2015-01-01

    Abstract Liver-related death in human immunodeficiency virus (HIV)-infected individuals is about 10 times higher compared with the general population, and the prevalence of significant liver fibrosis in those with HIV approaches 15%. The present study aimed to assess risk factors for development of hepatic fibrosis in HIV patients receiving a modern combination anti-retroviral therapy (cART). This cross-sectional prospective study included 432 HIV patients, of which 68 (16%) patients were anti-hepatitis C virus (HCV) positive and 23 (5%) were HBsAg positive. Health trajectory including clinical characteristics and liver fibrosis stage assessed by transient elastography were collected at inclusion. Liver stiffness values >7.1 kPa were considered as significant fibrosis, while values >12.5 kPa were defined as severe fibrosis. Logistic regression and Cox regression uni- and multivariate analyses were performed to identify independent factors associated with liver fibrosis. Significant liver fibrosis was detected in 10% of HIV mono-infected, in 37% of HCV co-infected patients, and in 18% of hepatitis B virus co-infected patients. The presence of diabetes mellitus (odds ratio [OR] = 4.6) and FIB4 score (OR = 2.4) were independently associated with presence of significant fibrosis in the whole cohort. Similarly, diabetes mellitus (OR = 5.4), adiposity (OR = 4.6), and the FIB4 score (OR = 3.3) were independently associated with significant fibrosis in HIV mono-infected patients. Importantly, cumulative cART duration protected, whereas persistent HIV viral replication promoted the development of significant liver fibrosis along the duration of HIV infection. Our findings strongly indicate that besides known risk factors like metabolic disorders, HIV may also have a direct effect on fibrogenesis. Successful cART leading to complete suppression of HIV replication might protect from development of liver fibrosis. PMID:26683921

  9. Salmonella collected from nest run cart shelves in commercial shell egg processing facilities.

    Science.gov (United States)

    Musgrove, M T; Shaw, J D; Harrison, M A

    2012-09-01

    Salmonella, a member of the bacterial family Enterobacteriaceae, may be recovered from foods and processing facilities. High levels of Enterobacteriaceae in the processing plant environment can be an indication of inadequate sanitation. This experiment was designed to determine if nest run egg carts serve as reservoirs for Salmonella. Eggs that are produced by hens not housed in buildings connected to the processing plant are referred to as nest run. Many of these eggs are transported to a central processing facility before they are washed, graded, and packed. Two plants in the Southeastern United States were sampled; one was a mixed operation and the other was an off-line operation. On each of 3 visits, 5 shelves on each of 5 carts were sampled (n = 25/visit). A 12 × 12 cm area on each shelf was swabbed with a sterile gauze pad moistened with PBS and transported on ice back to the laboratory. Each swab was preenriched in buffered peptone at 37°C for 24 h, selectively enriched using TT and Rappaport-Vassiliadis broth at 42°C overnight, then plated onto brilliant green sulfa and XLT-4 incubated at 37°C for 24 h. Presumptive colonies were transferred to lysine iron agar and triple sugar iron slants for 24 h at 37°C. Isolates with presumptive reactions were confirmed using commercial polyclonal antisera. After initial confirmation, serogrouping was performed using commercial antisera. Mixed-operation swab samples were 12% positive for Salmonella, whereas off-line samples were 36% positive for Salmonella; isolates were confirmed as serogroups B, C1, and C2. Kauffman-White serotyping was performed by a contract laboratory. Serotypes (n = 30) recovered were Anatum, Heidelberg, Infantis, Kentucky, Mbandanka, and Typhimurium. This work demonstrated that nest run egg carts may serve as reservoirs for Salmonella in the shell egg processing environment.

  10. Validation of the V(max) metabolic cart in a simulated pediatric model.

    Science.gov (United States)

    Wines, Kristen N; Rzepecki, Alexandra K; Andrews, Audrey L; Dechert, Ronald E

    2015-03-01

    The ability to accurately measure resting energy expenditure (REE) using indirect calorimetry, often referred to as the "gold standard" in nutrition needs assessment, is important given the well-established positive correlation between patient outcome and proportion of the nutrition goal met. While many studies have been done to compare various metabolic carts with one another, the literature lacks a large simulator-based validation of any metabolic cart system. In the present study, 8 specifically trained staff members independently conducted 10 simulation trials each using the V(max) Encore metabolic analyzer in conjunction with a metabolic calibration system, which simulates patient metabolic activity, to validate the accuracy of the V(max) Encore across a wide range of simulated metabolic conditions. Testing conditions consisted of incremental adjustments in calibrated gas infusion with a consistently set tidal volume and respiratory rate. There was a strong, statistically significant correlation between the predicted and actual VO2 and VCO2 data (VO2, R (2) = 0.998; VCO2, R (2) = 0.997). In addition, we observed no significant difference between individuals performing these trials (VO2, P = 1.000, F = 0.021, df = 79; VCO2, P = 1.000, F = 0.030, df = 79). This study is the first to report on such a wide spectrum of metabolic activity (50-2000 kcal REE) using a calibrated bench model and validates the accuracy, reproducibility, and use of the V(max) Encore metabolic cart. © 2014 American Society for Parenteral and Enteral Nutrition.

  11. First Results from HOTSPOT: The Snake River Plain Scientific Drilling Project, Idaho, U.S.A.

    Directory of Open Access Journals (Sweden)

    John W. Shervais

    2013-03-01

    Full Text Available HOTSPOT is an international collaborative effort to understand the volcanic history of the Snake River Plain (SRP. The SRP overlies a thermal anomaly, the Yellowstone-Snake River hotspot, that is thought to represent a deep-seated mantle plume under North America. Theprimary goal of this project is to document the volcanic and stratigraphic history of the SRP, which represents the surface expression of this hotspot, and to understand how it affected the evolution of continental crust and mantle. An additional goal is to evaluate the geothermal potential of southern Idaho.Project HOTSPOT has completed three drill holes. (1 The Kimama site is located along the central volcanic axis of the SRP; our goal here was to sample a long-term record of basaltic volcanism in the wake of the SRP hotspot. (2 The Kimberly site is located near the margin of the plain; our goal here was to sample a record of high-temperaturerhyolite volcanism associated with the underlying plume. This site was chosen to form a nominally continuous record of volcanism when paired with the Kimama site. (3 The Mountain Home site is located in the western plain; our goal here was to sample the Pliocene-Pleistocene transition in lake sediments at this site and to sample older basalts that underlie the sediments.We report here on our initial results for each site, and on some of the geophysical logging studies carried out as part of this project.

  12. Loading of carts in barges at HHM, Shanghai, beginning December 2000.

    CERN Multimedia

    F. Feyzi

    2000-01-01

    End of manufacture of encap carts at HHM in Shanghai. HHM has done an excellent job in manufacturing these parts with high quality and on time. HHM Vice General Manager Mr. Zhao Cheng Xiang hosted an excellent farewell dinner for F. Feyzi and J. Wollert on December 1 where all colleagues from HHM who have worked with us over the past two years were present. Each person played a key role in the success of the project and F. Feyzi thanked them individually on behalf of CMS.

  13. La carte, ça sert d'abord à enseigner la géographie

    Directory of Open Access Journals (Sweden)

    Jean-François Joly

    1999-12-01

    Full Text Available L'introduction d'un exercice de cartographie au baccalauréat fournit l'occasion de réfléchir aux méthodes et aux stratégies pédagogiques qu'il convient de mettre en œuvre afin de préparer efficacement les élèves. C'est surtout l'occasion de rappeler qu'il n'y a pas de géographie sans carte.

  14. Ensayo de resistencia a la compresión de cartón ondulado

    OpenAIRE

    García Bol, Ana María

    2013-01-01

    Por medio de este trabajo se puede observar la importancia de un sistema de calidad en la empresa. Los ensayos de ECT realizados en el laboratorio pretenden cumplir los requisitos propios y del cliente, siendo esto básico y asociado al concepto de calidad, no sólo en la industria del cartón ondulado sino en todas las restantes. Hemos visto todo el proceso productivo, ensayos, resultados mediante control estadístico, además de realizar ensayos de gramaje, comentar la trazabilidad y la política...

  15. New developments of the CARTE thermochemical code: A two-phase equation of state for nanocarbons

    Energy Technology Data Exchange (ETDEWEB)

    Dubois, Vincent, E-mail: vincent-jp.dubois@cea.fr; Pineau, Nicolas [CEA, DAM, DIF, F-91297 Arpajon (France)

    2016-01-07

    We developed a new equation of state (EOS) for nanocarbons in the thermodynamic range of high explosives detonation products (up to 50 GPa and 4000 K). This EOS was fitted to an extensive database of thermodynamic properties computed by molecular dynamics simulations of nanodiamonds and nano-onions with the LCBOPII potential. We reproduced the detonation properties of a variety of high explosives with the CARTE thermochemical code, including carbon-poor and carbon-rich explosives, with excellent accuracy.

  16. Putting the horse before the cart: a pragmatist analysis of knowledge

    Directory of Open Access Journals (Sweden)

    Luís M. Augusto

    2011-01-01

    Full Text Available The definition of knowledge as justified true belief is the best we presently have. However, the canonical tripartite analysis of knowledge does not do justice to it due to a Platonic conception of a priori truth that puts the cart before the horse. Within a pragmatic approach, I argue that by doing away with a priori truth, namely by submitting truth to justification, and by accordingly altering the canonical analysis of knowledge, this is a fruitful definition. So fruitful indeed that it renders the Gettier counterexamples vacuous, allowing positive work in epistemology and related disciplines.

  17. Cocaine- and amphetamine-regulated transcript peptide (CART) in the brain of zebra finch, Taeniopygia guttata: Organization, interaction with neuropeptide Y, and response to changes in energy status.

    Science.gov (United States)

    Singh, Omprakash; Kumar, Santosh; Singh, Uday; Kumar, Vinod; Lechan, Ronald M; Singru, Praful S

    2016-10-15

    Cocaine- and amphetamine-regulated transcript (CART) has emerged as a potent anorectic agent. CART is widely distributed in the brain of mammals, amphibians, and teleosts, but the relevant information in avian brain is not available. In birds, CART inhibits food intake, whereas neuropeptide Y (NPY), a well-known orexigenic peptide, stimulates it. How these neuropeptides interact in the brain to regulate energy balance is not known. We studied the distribution of CART-immunoreactivity in the brain of zebra finch, Taeniopygia guttata, its interaction with NPY, and their response to dynamic energy states. CART-immunoreactive fibers were found in the subpallium, hypothalamus, midbrain, and brainstem. Conspicuous CART-immunoreactive cells were observed in the bed nucleus of the stria terminalis, hypothalamic paraventricular, supraoptic, dorsomedial, infundibular (IN), lateral hypothalamic, Edinger-Westphal, and parabrachial nuclei. Hypothalamic sections of fed, fasted, and refed animals were immunostained with cFos, NPY, and CART antisera. Fasting dramatically increased cFos- and NPY-immunoreactivity in the IN, followed by rapid reduction by 2 hours and restoration to normal fed levels 6-10 hours after refeeding. CART-immunoreactive fibers in IN showed a significant reduction during fasting and upregulation with refeeding. Within the IN, double immunofluorescence revealed that 94 ± 2.1% of NPY-immunoreactive neurons were contacted by CART-immunoreactive fibers and 96 ± 2.8% NPY-immunoreactive neurons expressed cFos during fasting. Compared to controls, superfused hypothalamic slices of fasted birds treated with CART-peptide showed a significant reduction (P CART in the brain of T. guttata may perform several functions, and has a particularly important role in the hypothalamic regulation of energy homeostasis. J. Comp. Neurol. 524:3014-3041, 2016. © 2016 Wiley Periodicals, Inc.

  18. Application of flood index in monitoring Flood-plain ecosystems (by the example of the Middle Ob flood-plain)

    OpenAIRE

    Bolotnov, V. P.

    2007-01-01

    The concept of regional hydroecological monitoring has been developed for the flood-plain of the Middle Ob. Its object is to control the state of flood-plain ecosystem productivity for organization of scientific, regional-adopted and ecologically regulated nature management. For this purpose hydroecological zoning of flood-plain territory performed, the most representative stations of water-gauge observations for each flood-plain zone organized, the scheme of flood-plain flooding was prepared...

  19. Comparison of single and boosted protease inhibitor versus nonnucleoside reverse transcriptase inhibitor-containing cART regimens in antiretroviral-naïve patients starting cART after January 1, 2000

    DEFF Research Database (Denmark)

    Mocroft, A; Horban, A; Clumeck, N

    2006-01-01

    increase) response in antiretroviral-naïve patients starting either a single protease inhibitor (PI; n = 183), a ritonavir-boosted PI regimen (n = 197), or a nonnucleoside reverse transcriptase inhibitor (NNRTI)-based cART regimen (n = 447) after January 1, 2000, and the odds of lack of virologic...... or immunologic response at 3 years after starting cART. METHOD: Cox proportional hazards models and logistic regression. RESULTS: After adjustment, compared to patients taking an NNRTI-regimen, patients taking a single-PI regimen were significantly less likely to achieve a viral load (VL)

  20. Neuronal Stress and Injury Caused by HIV-1, cART and Drug Abuse: Converging Contributions to HAND

    Directory of Open Access Journals (Sweden)

    Ana B. Sanchez

    2017-02-01

    Full Text Available Multiple mechanisms appear to contribute to neuronal stress and injury underlying HIV-associated neurocognitive disorders (HAND, which occur despite the successful introduction of combination antiretroviral therapy (cART. Evidence is accumulating that components of cART can itself be neurotoxic upon long-term exposure. In addition, abuse of psychostimulants, such as methamphetamine (METH, seems to compromise antiretroviral therapy and aggravate HAND. However, the combined effect of virus and recreational and therapeutic drugs on the brain is still incompletely understood. However, several lines of evidence suggest a shared critical role of oxidative stress, compromised neuronal energy homeostasis and autophagy in promotion and prevention of neuronal dysfunction associated with HIV-1 infection, cART and psychostimulant use. In this review, we present a synopsis of recent work related to neuronal stress and injury induced by HIV infection, antiretrovirals (ARVs and the highly addictive psychostimulant METH.

  1. Neuronal Stress and Injury Caused by HIV-1, cART and Drug Abuse: Converging Contributions to HAND.

    Science.gov (United States)

    Sanchez, Ana B; Kaul, Marcus

    2017-02-23

    Multiple mechanisms appear to contribute to neuronal stress and injury underlying HIV-associated neurocognitive disorders (HAND), which occur despite the successful introduction of combination antiretroviral therapy (cART). Evidence is accumulating that components of cART can itself be neurotoxic upon long-term exposure. In addition, abuse of psychostimulants, such as methamphetamine (METH), seems to compromise antiretroviral therapy and aggravate HAND. However, the combined effect of virus and recreational and therapeutic drugs on the brain is still incompletely understood. However, several lines of evidence suggest a shared critical role of oxidative stress, compromised neuronal energy homeostasis and autophagy in promotion and prevention of neuronal dysfunction associated with HIV-1 infection, cART and psychostimulant use. In this review, we present a synopsis of recent work related to neuronal stress and injury induced by HIV infection, antiretrovirals (ARVs) and the highly addictive psychostimulant METH.

  2. Psychometric properties of the Belgian coach version of the coach-athlete relationship questionnaire (CART-Q).

    Science.gov (United States)

    Balduck, A-L; Jowett, S

    2010-10-01

    The study examined the psychometric properties of the Belgian coach version of the Coach-Athlete Relationship Questionnaire (CART-Q). The questionnaire includes three dimensions (Closeness, Commitment, and Complementarity) in a model that intends to measure the quality of the coach-athlete relationship. Belgian coaches (n=144) of athletes who performed at various competition levels in such sports as football, basketball, and volleyball responded to the CART-Q and to the Leadership Scale for Sport (LSS). A confirmatory factor analysis proved to be slightly more satisfactory for a three-order factor model, compared with a hierarchical first-order factor model. The three factors showed acceptable internal consistency scores. Moreover, functional associations between the three factors and coach leadership behaviors were found offering support to the instrument's concurrent validity. The findings support previous validation studies and verify the psychometric properties of the CART-Q applied to Belgian coaches of team sports.

  3. Estimated historical distribution of grassland communities of the Southern Great Plains

    Science.gov (United States)

    Reese, Gordon C.; Manier, Daniel J.; Carr, Natasha B.; Callan, Ramana; Leinwand, Ian I.F.; Assal, Timothy J.; Burris, Lucy; Ignizio, Drew A.

    2016-12-07

    The purpose of this project was to map the estimated distribution of grassland communities of the Southern Great Plains prior to Euro-American settlement. The Southern Great Plains Rapid Ecoregional Assessment (REA), under the direction of the Bureau of Land Management and the Great Plains Landscape Conservation Cooperative, includes four ecoregions: the High Plains, Central Great Plains, Southwestern Tablelands, and the Nebraska Sand Hills. The REA advisors and stakeholders determined that the mapping accuracy of available national land-cover maps was insufficient in many areas to adequately address management questions for the REA. Based on the recommendation of the REA stakeholders, we estimated the potential historical distribution of 10 grassland communities within the Southern Great Plains project area using data on soils, climate, and vegetation from the Natural Resources Conservation Service (NRCS) including the Soil Survey Geographic Database (SSURGO) and Ecological Site Information System (ESIS). The dominant grassland communities of the Southern Great Plains addressed as conservation elements for the REA area are shortgrass, mixed-grass, and sand prairies. We also mapped tall-grass, mid-grass, northwest mixed-grass, and cool season bunchgrass prairies, saline and foothill grasslands, and semi-desert grassland and steppe. Grassland communities were primarily defined using the annual productivity of dominant species in the ESIS data. The historical grassland community classification was linked to the SSURGO data using vegetation types associated with the predominant component of mapped soil units as defined in the ESIS data. We augmented NRCS data with Landscape Fire and Resource Management Planning Tools (LANDFIRE) Biophysical Settings classifications 1) where NRCS data were unavailable and 2) where fifth-level watersheds intersected the boundary of the High Plains ecoregion in Wyoming. Spatial data representing the estimated historical distribution of

  4. Widespread Plains Volcanism on Mercury Ended by 3.6 Ga

    Science.gov (United States)

    Byrne, P. K.; Ostrach, L. R.; Fassett, C.; Chapman, C. R.; Evans, A. J.; Klimczak, C.; Banks, M. E.; Head, J. W., III; Solomon, S. C.

    2015-12-01

    The largest volcanic plains deposits on Mercury are situated in its northern hemisphere and include the extensive northern smooth plains and the Caloris interior plains. Crater size-frequency analyses have shown that both deposits were emplaced around 3.8 Ga, for any of the published model production function (MPF) chronologies for impact crater formation on Mercury. The largest volcanic deposit in the southern hemisphere, the Rembrandt interior plains, has a model age of ~3.7 Ga. To test the hypothesis that all major volcanic smooth plains on Mercury were emplaced at about the same time, we determined crater size-frequency distributions for nine additional deposits (see Table 1). The diameters of craters that superpose the smooth plains at each site were measured with CraterTools, yielding crater areal densities in terms of N(10), the number of craters ≥10 km in diameter per 106 km2 area (Table 1). Our crater density measurements span N(10) values of 29-146, a range that encompasses corresponding values for the larger areas of smooth plains. With CraterStats, we fit our data (for craters ≥4 km in diameter) to the MPF chronologies of Le Feuvre and Wieczorek. For porous scaling, the model ages of all nine sites span a narrow window (Table 1). Non-porous scaling fails to match the crater size-frequency distributions. We show that widespread plains volcanism, likely the primary process by which Mercury's crust developed, had ended by 3.6 Ga. Younger volcanic deposits have been identified on the planet, but only within impact structures and at volumes much less than the smallest deposit considered here. Superposition relations between shortening landforms and craters on Mercury indicate that global contraction in response to interior cooling was underway by ~3.6 Ga. The cessation of widespread plains volcanism on Mercury may therefore reflect the onset of a stress state within the planet's lithosphere that inhibited magma ascent. Conversely, mantle thermochemical

  5. Cocaine- and amphetamine-regulated transcript (CART) peptide immunoreactivity in feeding- and reward-related brain areas of young OLETF rats.

    NARCIS (Netherlands)

    Armbruszt, S.; Abraham, H.; Figler, M.; Kozicz, T.L.; Hajnal, A.

    2013-01-01

    Cocaine- and amphetamine-regulated transcript (CART) peptide is expressed in brain areas involved in the control of appetite, drug reward and homeostatic regulation and it has an overall anorexigenic effect. Recently, we have shown that CART peptide immunoreactivity was significantly reduced in the

  6. Use of CART analysis to differentiate pollen of red pine ( Pinus resinosa) and jack pine ( P. banksiana) in New England

    Science.gov (United States)

    Barton, Andrew M.; Nurse, Andrea M.; Michaud, Katelyn; Hardy, Sarah W.

    2011-01-01

    The identification of fossil pollen at the generic rather than species level is hampering progress in understanding the biogeography and dynamics of paleo-vegetation. We used CART analysis to facilitate the differentiation of fossil pollen of Pinus banksiana and Pinusresinosa, which are morphologically similar and nearly always combined in paleoecological studies. The CART model, using four of the ten morphological traits measured, exhibited a high level of correct identification for pollen of each of the species and shows promise as a tool for increasing the detail of paleoecological records and inferences.

  7. A Case Illustrating the Costs of Quality Improvement: Nine Months to Move Needles and Syringes on the Anesthesia Cart.

    Science.gov (United States)

    Quick, Alexander K; Macario, Alex; Brock-Utne, John G; Jaffe, Richard A; Kadry, Bassam

    2015-09-01

    Powerful entities are pushing physicians to become more involved with quality improvement (QI). We report a QI project to standardize and improve the ergonomics of the anesthesia medication and supply cart. Simply obtaining approval to make minor changes to the cart involved 54 phone calls, 164 e-mails, 4 presentations, 2 forms, 9 meetings, and 4 months of time. Confusion over fiscal matters further delayed the project by an additional 3 months. A combination of competing regulations, administrative overprocessing, and the lack of dedicated QI financial resources made simple improvements a challenge. The costs of participating in QI deserve attention.

  8. Queratoquiste odontogénico con cartílago en la pared: presentación de un caso

    OpenAIRE

    Vicente Barrero, Mario; Báez Marrero, Oswaldo; Alfonso Martín, Juan Luis; Knezevic, Milan; Báez Acosta, Beatriz

    2004-01-01

    Existen siete casos publicados en la literatura médica referentes a la presencia de cartílago en la pared de un queratoquiste. Presentamos un nuevo caso con inclusiones de queratina y cartílago en la pared quística. Incluimos imágenes clínicas, radiográficas e histopatológicas, así como sus posibilidades etiopatogénicas. There are seven published cases in world literature on cartilage in the walls of odontogenic keratocysts. Herein is presented one further case with ke...

  9. Queratoquiste odontogénico con cartílago en la pared: presentación de un caso

    OpenAIRE

    M Vicente Barrero; Báez Marrero, Oswaldo; Alfonso Martín, Juan Luis; Knezevic, Milan; Báez Acosta, Beatriz

    2004-01-01

    Existen siete casos publicados en la literatura médica referentes a la presencia de cartílago en la pared de un queratoquiste. Presentamos un nuevo caso con inclusiones de queratina y cartílago en la pared quística. Incluimos imágenes clínicas, radiográficas e histopatológicas, así como sus posibilidades etiopatogénicas. There are seven published cases in world literature on cartilage in the walls of odontogenic keratocysts. Herein is presented one further case with ke...

  10. Aux frontières poreuses des cartes palestiniennes et de l'art contemporain

    Directory of Open Access Journals (Sweden)

    Anaïs Farine

    2013-12-01

    Full Text Available Un certain nombre d'artistes contemporains palestiniens se saisissent de la carte comme motif (simple présence de carte traditionnelle dans l'espace des œuvres ou comme modèle conceptuel structurant leurs travaux. A travers l'analyse des vidéos M* of Bethlehem [Ayreen Anastas, 2003], Red, Dead and Mediterranean [Akram Al-Ashqar, 2006], et We Began by Measuring Distance [Basma Al-sharif, 2009], cet article entend étudier le déplacement des frontières artistiques ainsi que des représentations de l'espace géopolitique dans les images en mouvements palestiniennes contemporaines. En interrogeant les différents dispositifs mis en place par les trois artistes pour se réapproprier le territoire en lui donnant un sens et une unité, cet article indique que ces œuvres, parce qu'elles répondent avec une grande subtilité aux préoccupations spatiales d'une certaine mouvance de l'art contemporain, sont devenues incontournables.

  11. Method of Inequalities-based Multiobjective Genetic Algorithm for Optimizing a Cart-double-pendulum System

    Institute of Scientific and Technical Information of China (English)

    Tung-Kuan Liu; Chiu-Hung Chen; Zu-Shu Li; Jyh-Horng Chou

    2009-01-01

    This article presents a multiobjective approach to the design of the controller for the swing-up and handstand control of a general cart-double-pendulum system (CDPS).The designed controller,which is based on the human-simulated intelligent control (HSIC) method,builds up different control modes to monitor and control the CDPS during four kinetic phases consisting of an initial oscillation phase,a swing-up phase,a posture adjustment phase,and a balance control phase.For the approach,the original method of inequalities-based (MoI) multiobjective genetic algorithm (MMGA) is extended and applied to the case study which uses a set of performance indices that includes the cart displacement over the rail boundary,the number of swings,the settling time,the overshoot of the total energy,and the control effort.The simulation results show good responses of the CDPS with the controllers obtained by the proposed approach.

  12. A comparative study of CART and PTM for modelling water age

    Science.gov (United States)

    Wang, Haiyan; Guo, Xinyu; Liu, Zhe; Gao, Huiwang

    2015-02-01

    CART (Constituent-oriented age and residence time theory) and PTM (Particle-tracking method) are two widely used numerical methods to calculate water age. These two methods are essentially equivalent in theory but their results may be different in practice. The difference of the two methods was evaluated by applying them to calculate water age in an idealized one-dimensional domain. The model results by the two methods are consistent with each other in the case with either spatially uniform flow field or spatially uniform diffusion coefficient. If we allow the spatial variation in horizontal diffusion, a term called pseudo displacement arising from the spatial variation of diffusion coefficient likely plays an important role for the PTM to obtain accurate water age. In particular, if the water particle is released at a place where the diffusion is not the weakest, the water age calculated by the PTM without pseudo displacement is much larger than that by the CART. This suggests that the pseudo displacement cannot be neglected in the PTM to calculate water age in a realistic ocean. As an example, we present its potential importance in the Bohai Sea where the diffusion coefficient varies spatially and greatly.

  13. The prevalence of lameness and associated risk factors in cart mules in Bahir Dar, Ethiopia.

    Science.gov (United States)

    Ali, Alina; Orion, Solomon; Tesfaye, Tewodros; Zambriski, Jennifer A

    2016-10-01

    Ethiopia has 7.1 million donkeys and mules, the majority of which are used as pack animals. Factors such as poor harness quality, long-distance traveling, and heavy cartloads have been linked to reduced work efficiency. Addressing the health and welfare of working equids is imperative not only for the animals but also for the households dependent upon them for livelihood. In developing countries, 75 % of working equids have gait or limb abnormalities, but the relationship between workload and prevalence of lameness is unknown. We examined 450 cart mules in Bahir Dar, Ethiopia. Lameness and workload were assessed through use of a survey and lameness exam. We found that 26.8 % of cart mules were lame, and acute lameness of the forelimb was the most common. Animals with poor harness quality were 2.5 times more likely to have sores and 1.6 times more likely to be lame. Lameness tended to be associated with cartloads >700 kg (P = 0.09), and there was a significant association between multiple-leg lameness and cartload weight (P = 0.03). The presence of sores was the best predictor of lameness (P = 0.001). Possible areas of intervention may include education to reduce average daily workload and improving harness design.

  14. A Comparative Study of CART and PTM for Modelling Water Age

    Institute of Scientific and Technical Information of China (English)

    WANG Haiyan; GUO Xinyu; LIU Zhe; GAO Huiwang

    2015-01-01

    CART (Constituent-oriented age and residence time theory) and PTM (Particle-tracking method) are two widely used numerical methods to calculate water age. These two methods are essentially equivalent in theory but their results may be different in practice. The difference of the two methods was evaluated by applying them to calculate water age in an idealized one-dimensional domain. The model results by the two methods are consistent with each other in the case with either spatially uniform flow field or spatially uniform diffusion coefficient. If we allow the spatial variation in horizontal diffusion, a term called pseudo displacement arising from the spatial variation of diffusion coefficient likely plays an important role for the PTM to obtain accurate water age. In particular, if the water particle is released at a place where the diffusion is not the weakest, the water age calculated by the PTM without pseudo displacement is much larger than that by the CART. This suggests that the pseudo displacement cannot be neglected in the PTM to calculate water age in a realistic ocean. As an example, we present its potential importance in the Bohai Sea where the diffusion coefficient varies spatially and greatly.

  15. A Multivariable Adaptive Control Approach for Stabilization of a Cart-Type Double Inverted Pendulum

    Directory of Open Access Journals (Sweden)

    I. Hassanzadeh

    2011-01-01

    Full Text Available This paper considers the design and practical implementation of linear-based controllers for a cart-type double inverted pendulum (DIPC. A constitution of two linked pendulums placed on a sliding cart, presenting a three Degrees of Freedom and single controlling input structure. The controller objective is to keep both pendulums in an up-up unstable equilibrium point. Modeling is based on the Euler-Lagrange equations, and the resulted nonlinear model is linearized around up-up position. First, the LQR method is used to stabilize DIPC by a feedback gain matrix in order to minimize a quadratic cost function. Without using an observer to estimate the unmeasured states, in the next step we make use of LQG controller which combines the Kalman-Bucy filter estimation and LQR feedback control to obtain a better steady-state performance, but poor robustness. Eventually, to overcome the unknown nonlinear model parameters, an adaptive controller is designed. This controller is based on Model Reference Adaptive System (MRAS method, which uses the Lyapunov function to eliminate the defined state error. This controller improves both the steady-state and disturbance responses.

  16. A new approach to the reduction of "Carte du Ciel" plates

    CERN Document Server

    Ortiz-Gill, A; Brosche, P

    1997-01-01

    A new procedure for the reduction of "Carte du Ciel" plates is presented. A typical "Carte du Ciel" plate corresponding to the Bordeaux zone has been taken as an example. It shows triple exposures for each object and the modelling of the data has been performed by means of a non-linear least squares fitting of the sum of three bivariate Gaussian distributions. A number of solutions for the problems present in this kind of plates (optical aberrations, adjacency photographic effects, presence of grid lines, emulsion saturation) have been investigated. An internal accuracy of 0.1'' in x and y was obtained for the position of each of the individual exposures. The external reduction to a catalogue led to results with an accuracy of 0.16'' in x and 0.13'' in y for the mean position of the three exposures. A photometric calibration has also been performed and magnitudes were determined with an accuracy of 0.09 mags.

  17. It’s all change for the "carte de légitimation"

    CERN Multimedia

    2009-01-01

    From now on, the Swiss carte de légitimation will be issued to associates and users as well as staff members, and applications will be handled electronically, thus facilitating various procedures. In collaboration with the GS-AIS Group, the HR Department is continuing its modernisation of administrative procedures. Now that MARS forms and applications to participate in the saved leave scheme have been computerised and employment certificates and change of home address forms have been made available on line on a self-service basis, it’s the turn of the carte de légitimation to enter the digital era. In future, when a new card needs to be produced, the member of the personnel’s data will be forwarded electronically from CERN’s database to the database of the Swiss Federal Department of Foreign Affairs (DFAE), eliminating the need for a paper form. Similarly, paper ID photos will no longer be needed as the digital photo taken for ...

  18. DeCART v1.1 user's manual

    Energy Technology Data Exchange (ETDEWEB)

    Cho, J. Y.; Kim, K. S.; Kim, H. Y.; Lee, C. C.; Zee, S. Q.; Joo, H. G

    2005-03-15

    DeCART (Deterministic Core Analysis based on Ray Tracing) is a whole core neutron transport code capable of direct subpin level flux calculation at power generating conditions. It does not require a priori homogenization nor group condensation needed in conventional reactor physics calculations. The depletion and transient calculation capabilities are also available. This manual serves as a self-sufficient guide to use the code. First of all, the various features of the code are explained which encompass various modeling options as well as the basic calculation functionalities. The instructions for running the code are also given with a description of the output files generated. Next, the underlying concepts and principles of preparing a DeCART model for a problem under consideration are presented. Each part of the input needed to specify the geometry, material composition, thermal operating condition, program execution control parameters are explained with examples. The descriptions of all the input cards are then followed. Finally, various sample model inputs ranging from a simple 2D pin cell to a realistic 3D core problem, steady-state to transient problems, are presented.

  19. Loss of the HVEM Tumor Suppressor in Lymphoma and Restoration by Modified CAR-T Cells.

    Science.gov (United States)

    Boice, Michael; Salloum, Darin; Mourcin, Frederic; Sanghvi, Viraj; Amin, Rada; Oricchio, Elisa; Jiang, Man; Mottok, Anja; Denis-Lagache, Nicolas; Ciriello, Giovanni; Tam, Wayne; Teruya-Feldstein, Julie; de Stanchina, Elisa; Chan, Wing C; Malek, Sami N; Ennishi, Daisuke; Brentjens, Renier J; Gascoyne, Randy D; Cogné, Michel; Tarte, Karin; Wendel, Hans-Guido

    2016-10-01

    The HVEM (TNFRSF14) receptor gene is among the most frequently mutated genes in germinal center lymphomas. We report that loss of HVEM leads to cell-autonomous activation of B cell proliferation and drives the development of GC lymphomas in vivo. HVEM-deficient lymphoma B cells also induce a tumor-supportive microenvironment marked by exacerbated lymphoid stroma activation and increased recruitment of T follicular helper (TFH) cells. These changes result from the disruption of inhibitory cell-cell interactions between the HVEM and BTLA (B and T lymphocyte attenuator) receptors. Accordingly, administration of the HVEM ectodomain protein (solHVEM((P37-V202))) binds BTLA and restores tumor suppression. To deliver solHVEM to lymphomas in vivo, we engineered CD19-targeted chimeric antigen receptor (CAR) T cells that produce solHVEM locally and continuously. These modified CAR-T cells show enhanced therapeutic activity against xenografted lymphomas. Hence, the HVEM-BTLA axis opposes lymphoma development, and our study illustrates the use of CAR-T cells as "micro-pharmacies" able to deliver an anti-cancer protein.

  20. DeCART v1.2 User's Manual

    Energy Technology Data Exchange (ETDEWEB)

    Cho, J. Y.; Kim, K. S.; Kim, H. Y.; Lee, C. C.; Zee, S. Q; Joo, H. G

    2007-07-15

    DeCART (Deterministic Core Analysis based on Ray Tracing) is a whole core neutron transport code capable of direct subpin level flux calculation at power generating conditions. It does not require a priori homogenization nor group condensation needed in conventional reactor physics calculations. The depletion and transient calculation capabilities are also available. This manual serves as a self-sufficient guide to use the code. First of all, the various features of the code are explained which encompass various modeling options as well as the basic calculation functionalities. The instructions for running the code are also given with a description of the output files generated. Next, the underlying concepts and principles of preparing a DeCART model for a problem under consideration are presented. Each part of the input needed to specify the geometry, material composition, thermal operating condition, program execution control parameters are explained with examples. The descriptions of all the input cards are then followed. Finally, various sample model inputs ranging from a simple 2D pin cell to a realistic 3D core problem, steady-state to transient problems, and from rectangular to hexagonal core problems are presented.

  1. LAND SUITABILITY SCENARIOS FOR ARID COASTAL PLAINS USING GIS MODELING: SOUTHWESTERN SINAI COASTAL PLAIN, EGYPT

    Directory of Open Access Journals (Sweden)

    Ahmed Mohamed Wahid

    2009-12-01

    Full Text Available Site selection analysis was carried out to find the best suitable lands for development activities in an example of promising coastal plains, southwestern Sinai, Egypt. Two GIS models were developed to represent two scenarios of land use suitability in the study area using GIS Multi Criteria Analysis Modeling. The factors contributed in the analysis are the Topography, Land cover, Existing Land use, Flash flood index, Drainage lines and Water points. The first scenario was to classify the area according to various gradual ranges of suitability. According to this scenario, the area is classified into five classes of suitability. The percentage of suitability values are 51.16, 6.13, 22.32, 18.49 and 1.89% for unsuitable, least suitable, low suitable, suitable and high suitable, respectively. The second scenario is developed for a particular kind of land use planning; tourism and recreation projects. The suitability map of this scenario was classified into five values. Unsuitable areas represent 51.18% of the study area, least suitable 16.67%, low suitable 22.85%, suitable 8.61%, and high suitable 0.68%. The best area for locating development projects is the area surrounding El-Tor City and close to the coast. This area could be an urban extension of El-Tor City with more economical and environmental management.

  2. LAND SUITABILITY SCENARIOS FOR ARID COASTAL PLAINS USING GIS MODELING: SOUTHWESTERN SINAI COASTAL PLAIN, EGYPT

    Directory of Open Access Journals (Sweden)

    Ahmed Wahid

    2009-01-01

    Full Text Available Site selection analysis was carried out to find the best suitable lands for development activities in an example of promising coastal plains, southwestern Sinai, Egypt. Two GIS models were developed to represent two scenarios of land use suitability in the study area using GIS Multi Criteria Analysis Modeling. The factors contributed in the analysis are the Topography, Land cover, Existing Land use, Flash flood index, Drainage lines and Water points. The first scenario was to classify the area according to various gradual ranges of suitability. According to this scenario, the area is classified into five classes of suitability. The percentage of suitability values are 51.16, 6.13, 22.32, 18.49 and 1.89% for unsuitable, least suitable, low suitable, suitable and high suitable, respectively. The second scenario is developed for a particular kind of land use planning; tourism and recreation projects. The suitability map of this scenario was classified into five values. Unsuitable areas represent 51.18% of the study area, least suitable 16.67%, low suitable 22.85%, suitable 8.61%, and high suitable 0.68%. The best area for locating development projects is the area surrounding El-Tor City and close to the coast. This area could be an urban extension of El-Tor City with more economical and environmental management.

  3. Robust Smooth Time-varying Exponential Stabilization of Dynamic Nonholonomic Mobile Cart with Parameter Uncertainties%参数不确定移动小车的鲁棒镇定

    Institute of Scientific and Technical Information of China (English)

    马保离

    2005-01-01

    For regulating the dynamic nonholonomic mobile cart with parameter uncertainties, a time-varying robust control law is derived to yield globally exponential convergence of cart's position and orientation to the desired set point. The controller design relies on converting the cart's dynamics to an advantageous form, and the robust linear feedback control laws steer the cart's position and orientation errors to zero exponentially. Simulation results show the effectiveness of the proposed control law.

  4. Plain carbon steel bipolar plates for PEMFC

    Institute of Scientific and Technical Information of China (English)

    WANG Jianli; SUN Juncai; TIAN Rujin; XU Jing

    2006-01-01

    Bipolar plates are a multifunctional component of PEMFC. Comparing with the machined graphite and stainless steels, the plain carbon steel is a very cheap commercial metal material. In this paper, the possibility of applying the plain carbon steels in the bipolar plate for PEMFC was exploited. In order to improve the corrosion resistance of the low carbon steel in the PEMFCs' environments,two surface modification processes was developed and then the electrochemical performances and interfacial contact resistance (ICR) of the surface modified plate of plain carbon steel were investigated. The results show that the surface modified steel plates have good corrosion resistance and relatively low contact resistance, and it may be a candidate material as bipolar plate of PEMFC.

  5. Alluvial plain dynamics in the southern Amazonian foreland basin

    Science.gov (United States)

    Lombardo, Umberto

    2016-05-01

    Alluvial plains are formed with sediments that rivers deposit on the adjacent flood-basin, mainly through crevasse splays and avulsions. These result from a combination of processes, some of which push the river towards the crevasse threshold, while others act as triggers. Based on the floodplain sedimentation patterns of large rivers in the southern Amazonian foreland basin, it has been suggested that alluvial plain sediment accumulation is primarily the result of river crevasse splays and sheet sands triggered by above-normal precipitation events due to La Niña. However, more than 90 % of the Amazonian river network is made of small rivers and it is unknown whether small river floodplain sedimentation is influenced by the ENSO cycle as well. Using Landsat images from 1984 to 2014, here I analyse the behaviour of all 12 tributaries of the Río Mamoré with a catchment in the Andes. I show that these are very active rivers and that the frequency of crevasses is not linked to ENSO activity. The data suggest that most of the sediments eroded from the Andes by the tributaries of the Mamoré are deposited in the alluvial plains, before reaching the parent river. The mid-to-late Holocene paleo-channels of these rivers are located tens of kilometres further away from the Andes than the modern crevasses. I conclude that the frequency of crevasses is controlled by intrabasinal processes that act on a yearly to decadal timescale, while the average location of the crevasses is controlled by climatic or neo-tectonic events that act on a millennial scale. Finally, I discuss the implications of river dynamics on rural livelihoods and biodiversity in the Llanos de Moxos, a seasonally flooded savannah covering most of the southern Amazonian foreland basin and the world's largest RAMSAR site.

  6. Hydrogeochemical analysis for Tasuj plain aquifer, Iran

    Indian Academy of Sciences (India)

    Ata Allah Nadiri; Asghar Asghari Moghaddam; Frank T-C Tsai; Elham Fijani

    2013-08-01

    This study investigated the hydrogeochemical processes of groundwater in the Tasuj plain, Iran. The Tasuj plain is one of the 12 marginal plains around Urmia Lake which is currently under a critical ecological condition. In the last decades, the Tasuj plain aquifer suffered from severe groundwater level declination and caused degradation of groundwater quality. To better understand hydrogeochemical processes in the Tasuj plain, this study adopted graphical methods and multivariate statistical techniques to analyze groundwater samples. A total of 504 groundwater samples was obtained from 34 different locations (qanats, wells, and springs) over 12 years (1997–2009) and analyzed for 15 water quality parameters. From the results, the Piper diagram indicated four groundwater types and the Stiff diagram showed eight different sources of groundwater samples. The Durov diagram identified five major hydrogeochemical processes in the aquifer. However, hierarchical cluster analysis (HCA) identified five water types in the groundwater samples because HCA was able to analyze more chemical and physical data than graphical methods. The HCA result was checked by discriminant analysis and found consistency in all samples that were classified into correct groups. Using factor analysis, we identified three factors that accounted for 81.6% of the total variance of the dataset. Based on the high factor loadings of the variables, factors 1 and 2 reflected the natural hydrogeochemical processes and factor 3 explained the effect of agricultural fertilizers and human activities in the Tasuj plain. Dendrograms from 2000 to 2009 were studied to understand the temporal variation of groundwater quality. Comparing the distributions of groundwater types in 2000 and 2009, we found that the mixing zone was expanded. This may be due to artificial groundwater recharge in the recharge area and the effect of inverse ion exchange in the discharge area.

  7. An observational comparison of first-line combination antiretroviral treatment (cART with 2NRTI and ATV/r or DRV/r in HIV-infected patients in Italy

    Directory of Open Access Journals (Sweden)

    Alessandro Cozzi-Lepri

    2014-11-01

    Full Text Available Introduction: In a recent clinical trial (ACTG 5257, no difference in viral failure (VF of a first-line cART containing atazanavir/r (ATV/r or darunavir/r (DRV/r was found [1]. For the endpoint of discontinuation due to intolerance, the regimen with DRV/r was superior to that of ATV/r (49% of the stops of ATV/r were attributed to jaundice or hyperbilirubinemia. These and other intolerances to ATV/r remain a concern for clinicians. Methods: Participants in the ICONA Foundation Study who started cART with 2NRTI+ ATV/r or DRV/r while ART-naïve were included. Several endpoints were evaluated: confirmed VF>200 copies/mL after six months of therapy, discontinuation of DRV/r or ATV/r for any reasons or because of intolerance/toxicity (as reported by the treating physician and the combined endpoint of VF or stop. Survival analysis with Kaplan–Meier curves and Cox regression model stratified by clinical site was used. Patients’ follow-up accrued from cART initiation to the date of the event or to the date of last available visit/viral load. Results: 894 patients starting 2NRTI+ATV/r and 686 2NRTI+DRV/r when ART-naïve on average in 2011 (IQR: 2010–2012 were studied. Most common NRTIs used were FTC/TDF (84% and ABC/3TC (12%. Median age was 40 years, 22% females, 44% heterosexuals. Patients starting ATV/r were more likely to be hepatitis B/C infected (2% and 14% vs 1% and 9%, p=0.001, they started one year earlier (2011 vs 2012, p=0.001, were more likely to be enrolled in sites located in the north of Italy (63% vs 54%, p=0.04, started cART less promptly after HIV diagnosis (5 vs 2 months, p=0.02 and less likely to have started TDF/FTC (83% vs 85%, p=0.02. By two years of cART, 9.8% (95% CI 7.6–12.0 of those starting ATV/r experienced discontinuation due to intolerance/toxicity vs 6.5% in DRV/r group (95% CI 4.2–8.8, p=0.04. After controlling for several potential confounders (age, gender, nation of birth, mode of HIV transmission, hepatitis co

  8. An observational comparison of first-line combination antiretroviral treatment (cART) with 2NRTI and ATV/r or DRV/r in HIV-infected patients in Italy.

    Science.gov (United States)

    Cozzi-Lepri, Alessandro; Antinori, Andrea; Bonora, Stefano; Cingolani, Antonella; Cassola, Giovanni; Angarano, Gioacchino; Vullo, Vincenzo; Mussini, Cristina; Gori, Andrea; Maggiolo, Franco; Castagna, Antonella

    2014-01-01

    In a recent clinical trial (ACTG 5257), no difference in viral failure (VF) of a first-line cART containing atazanavir/r (ATV/r) or darunavir/r (DRV/r) was found [1]. For the endpoint of discontinuation due to intolerance, the regimen with DRV/r was superior to that of ATV/r (49% of the stops of ATV/r were attributed to jaundice or hyperbilirubinemia). These and other intolerances to ATV/r remain a concern for clinicians. Participants in the ICONA Foundation Study who started cART with 2NRTI+ ATV/r or DRV/r while ART-naïve were included. Several endpoints were evaluated: confirmed VF>200 copies/mL after six months of therapy, discontinuation of DRV/r or ATV/r for any reasons or because of intolerance/toxicity (as reported by the treating physician) and the combined endpoint of VF or stop. Survival analysis with Kaplan-Meier curves and Cox regression model stratified by clinical site was used. Patients' follow-up accrued from cART initiation to the date of the event or to the date of last available visit/viral load. 894 patients starting 2NRTI+ATV/r and 686 2NRTI+DRV/r when ART-naïve on average in 2011 (IQR: 2010-2012) were studied. Most common NRTIs used were FTC/TDF (84%) and ABC/3TC (12%). Median age was 40 years, 22% females, 44% heterosexuals. Patients starting ATV/r were more likely to be hepatitis B/C infected (2% and 14% vs 1% and 9%, p=0.001), they started one year earlier (2011 vs 2012, p=0.001), were more likely to be enrolled in sites located in the north of Italy (63% vs 54%, p=0.04), started cART less promptly after HIV diagnosis (5 vs 2 months, p=0.02) and less likely to have started TDF/FTC (83% vs 85%, p=0.02). By two years of cART, 9.8% (95% CI 7.6-12.0) of those starting ATV/r experienced discontinuation due to intolerance/toxicity vs 6.5% in DRV/r group (95% CI 4.2-8.8, p=0.04). After controlling for several potential confounders (age, gender, nation of birth, mode of HIV transmission, hepatitis co-infection status, AIDS diagnosis, nucleoside

  9. Drought Assessment in the Moldavian Plain

    Directory of Open Access Journals (Sweden)

    Pelin Liviu Ioan

    2016-06-01

    Full Text Available The Moldavian Plain, located in the North-Eastern part of Romania, has a temperate-continental climate with a nuance of excessivity in the precipitation regime. This paper aims to analyse droughts in the Moldavian Plain for the period 1961-2010, by using a classical method - the de Martonne Aridity Index, and two other less known indices developed in Romania and the Republic of Moldova. Among these indices, the Dry Spells Index demonstrates a increasing frequency of dry years in recent decades.

  10. Cross-culture revision of CART-Q%对教练员与运动员关系量表(CART-Q)的跨文化修订

    Institute of Scientific and Technical Information of China (English)

    钟日升; 王迪

    2010-01-01

    教练员与运动员关系时运动员的训练、生活和运动成绩均有重要的影响,因此国外许多运动心理学家尝试致力于此领域研究,但国内鲜有相关研究.英国运动心理学家Jowett近年提出的3C理论及CART-Q量表,通过研究证明该量表适用于中国教练员与运动员.针对中国举国体制的现实国情和传统文化对教练员与运动员的影响,对原量表进行了修订,获得该量表的中文修订版的心理测量学数据.研究发现CART-Q修订版比翻译版在中国使用具有更好的信度、效度.

  11. Mid-Wisconsinan environments on the eastern Great Plains

    Science.gov (United States)

    Baker, R. G.; Bettis, E. A., III; Mandel, R. D.; Dorale, J. A.; Fredlund, G. G.

    2009-05-01

    Few sites on the eastern Great Plains contain paleobotanical records for the mid-Wisconsin. We report on four sites, two stream cutbanks and two quarry exposures, ranging in age from >50 to ˜23.4 ka. The oldest site at >50 ka contains a suite of macrofossils from prairie and disturbed ground habitats, with no representation of trees, indicating an open prairie. By ˜38 ka the assemblages include aquatic, wetland, mudflat, and prairie elements with rare specimens of Populus, Betula cf. papyrifera, Salix and at the most northerly site, Picea. This assemblage suggests a prairie/parkland with interspersed marshes, cooler temperatures and increased moisture. Populus and Salix continued to be represented from ˜36 to ˜29 ka, but the only other taxon was Carex. A hiatus may be present at some time during this interval. After ˜29 ka, Picea became dominant on the uplands and it was joined by sedges in local wetlands. At sites near riverine loess sources, loess accumulation began to fill in the wetlands and organic deposition ceased some time after 29 ka.

  12. ESTIMATION OF S-WAVE VELOCITY STRUCTURE OF FUKUI PLAIN BASED ON MICROTREMOR ARRAY OBSERVATION

    Science.gov (United States)

    Kojima, Keisuke; Moto, Koudai

    The precise evaluations of Quaternary structure of the region are indispensable in order to accurately predict the seismic damage. However, deep borehole, PS-logging and elastic wave exploration have been executed only on limited points around the Fukui Plain. The problem analyzed in this study is statistical estimation of the 3D S-wave velocity structure down to the Tertiary bedrock of the Fukui Plain based on the data from 75 microtremor array observation sites. The Rayleigh wave phase velocities at each array site were calculated by the spatial autocorrelation method. The phase velocities at each site were inverted to a 1D S-wave profile using a genetic inversion. The 3-components single-site microtremor observations were carried out to compensate the array observations. The 3D S-wave velocity structure around the Fukui plain have been interpolated by using Kriging and Co-Kriging techniques. In the Co-Kriging procedure, the correlations between the estimated depths of Quaternary and the observed predominant periods of the sites were taken into account. The validity of the estimated structure from the microtremor observation was confirmed by comparing with the density structure and with the existing PS-logging data.

  13. Estimating canopy fuel parameters for Atlantic Coastal Plain forest types.

    Energy Technology Data Exchange (ETDEWEB)

    Parresol, Bernard, R.

    2007-01-15

    Abstract It is necessary to quantify forest canopy characteristics to assess crown fire hazard, prioritize treatment areas, and design treatments to reduce crown fire potential. A number of fire behavior models such as FARSITE, FIRETEC, and NEXUS require as input four particular canopy fuel parameters: 1) canopy cover, 2) stand height, 3) crown base height, and 4) canopy bulk density. These canopy characteristics must be mapped across the landscape at high spatial resolution to accurately simulate crown fire. Currently no models exist to forecast these four canopy parameters for forests of the Atlantic Coastal Plain, a region that supports millions of acres of loblolly, longleaf, and slash pine forests as well as pine-broadleaf forests and mixed species broadleaf forests. Many forest cover types are recognized, too many to efficiently model. For expediency, forests of the Savannah River Site are categorized as belonging to 1 of 7 broad forest type groups, based on composition: 1) loblolly pine, 2) longleaf pine, 3) slash pine, 4) pine-hardwood, 5) hardwood-pine, 6) hardwoods, and 7) cypress-tupelo. These 7 broad forest types typify forests of the Atlantic Coastal Plain region, from Maryland to Florida.

  14. Water-level change, High Plains aquifer, 1980 to 1995

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This raster data set represents water-level change in the High Plains aquifer of the United States from 1980 to 1995, in feet. The High Plains aquifer underlies...

  15. Water-level change, High Plains aquifer, 1995 to 2000

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This raster data set represents water-level change in the High Plains aquifer of the United States from 1995 to 2000, in feet. The High Plains aquifer underlies...

  16. Water-level change, High Plains aquifer, 2005 to 2009

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This raster data set represents water-level change in the High Plains aquifer of the United States from 2005 to 2009, in feet. The High Plains aquifer underlies...

  17. Water-level change, High Plains aquifer, 2000 to 2005

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This raster data set represents water-level change in the High Plains aquifer of the United States from 2000 to 2005, in feet. The High Plains aquifer underlies...

  18. Classification and regression tree (CART model to predict pulmonary tuberculosis in hospitalized patients

    Directory of Open Access Journals (Sweden)

    Aguiar Fabio S

    2012-08-01

    Full Text Available Abstract Background Tuberculosis (TB remains a public health issue worldwide. The lack of specific clinical symptoms to diagnose TB makes the correct decision to admit patients to respiratory isolation a difficult task for the clinician. Isolation of patients without the disease is common and increases health costs. Decision models for the diagnosis of TB in patients attending hospitals can increase the quality of care and decrease costs, without the risk of hospital transmission. We present a predictive model for predicting pulmonary TB in hospitalized patients in a high prevalence area in order to contribute to a more rational use of isolation rooms without increasing the risk of transmission. Methods Cross sectional study of patients admitted to CFFH from March 2003 to December 2004. A classification and regression tree (CART model was generated and validated. The area under the ROC curve (AUC, sensitivity, specificity, positive and negative predictive values were used to evaluate the performance of model. Validation of the model was performed with a different sample of patients admitted to the same hospital from January to December 2005. Results We studied 290 patients admitted with clinical suspicion of TB. Diagnosis was confirmed in 26.5% of them. Pulmonary TB was present in 83.7% of the patients with TB (62.3% with positive sputum smear and HIV/AIDS was present in 56.9% of patients. The validated CART model showed sensitivity, specificity, positive predictive value and negative predictive value of 60.00%, 76.16%, 33.33%, and 90.55%, respectively. The AUC was 79.70%. Conclusions The CART model developed for these hospitalized patients with clinical suspicion of TB had fair to good predictive performance for pulmonary TB. The most important variable for prediction of TB diagnosis was chest radiograph results. Prospective validation is still necessary, but our model offer an alternative for decision making in whether to isolate patients with

  19. Design of an automated cart and mount for a hyperspectral imaging system to be used in produce fields

    Science.gov (United States)

    The goal of this project was to construct a cart and a mounting system that would allow a hyperspectral laser-induced fluorescence imaging system (HLIFIS) to be used to detect fecal material in produce fields. Fecal contaminated produce is a recognized food safety risk. Previous research demonstrate...

  20. Turning a Common Lab Exercise into a Challenging Lab Experiment: Revisiting the Cart on an Inclined Track

    Science.gov (United States)

    Amato, Joseph C.; Williams, Roger E.

    2010-01-01

    A common lab exercise in the introductory college physics course employs a low-friction cart and associated track to study the validity of Newton's second law. Yet for college students, especially those who have already encountered a good high school physics course, the exercise must seem a little pointless. These students have already learned to…

  1. 循迹小车的追踪与避障%The Tracing and Obstacle Avoidance of Tracking Carts

    Institute of Scientific and Technical Information of China (English)

    王宇洋; 许志; 杨柳; 张家一; 张晓亮

    2012-01-01

    This paper introduces the design and realization of auto-tracking carts based on the use of gray level sensors. This cart tracks certain black lines on the white floor. When detecting objects at front, the cart starts to chase the object. By changing the pro- grams, the cart can avoid obstacles and turn itself automatically.%介绍了采用灰度传感器的自循迹小车的设计与实现,并加以追踪与避障的功能。采用与白色地面反差很大的黑色路线引导小车按既定路线前进,若接近开关检测到物体时,实现追踪功能。通过改编程序,同样利用这两个接近开关可实现避障功能,即遇到障碍物时,自动转弯。

  2. Wagging the Dog, Carting the Horse: Testing and Improving Schools. Summary of Conference Proceedings. Research into Practice Project.

    Science.gov (United States)

    Herman, Joan; And Others

    The purpose of the conference, "Wagging the Dog, Carting the Horse: Testing vs. Improving California Schools," was to discuss alternative perspectives on testing and evaluation in education and their role in improving teaching and learning. Four papers were presented: (1) "Using Educational Evaluation for the Improvement of California Schools," by…

  3. Comparison of buffet and a la carte serving at worksite canteens on nutrient intake and fruit and vegetable consumption

    DEFF Research Database (Denmark)

    Lassen, Anne Dahl; Hansen, K.S.; Trolle, Ellen

    2007-01-01

    Objective: To evaluate the nutritional composition of worksite canteen lunches and to examine the impact of two meal serving systems on employee intake, i.e. buffet style with a fixed price for a varied number of dishes and A la carte style with a separate price for each item on the menu. Design...

  4. Electrophysiological characteristics of paraventricular thalamic (PVT) neurons in response to cocaine and cocaine- and amphetamine-regulated transcript (CART).

    Science.gov (United States)

    Yeoh, Jiann Wei; James, Morgan H; Graham, Brett A; Dayas, Christopher V

    2014-01-01

    Recent work has established that the paraventricular thalamus (PVT) is a central node in the brain reward-seeking pathway. This role is mediated in part through projections from hypothalamic peptide transmitter systems such as cocaine- and amphetamine-regulated transcript (CART). Consistent with this proposition, we previously found that inactivation of the PVT or infusions of CART into the PVT suppressed drug-seeking behavior in an animal model of contingent cocaine self-administration. Despite this work, few studies have assessed how the basic physiological properties of PVT neurons are influenced by exposure to drugs such as cocaine. Further, our previous work did not assess how infusions of CART, which we found to decrease cocaine-seeking, altered the activity of PVT neurons. In the current study we address these issues by recording from anterior PVT (aPVT) neurons in acutely prepared brain slices from cocaine-treated (15 mg/ml, n = 8) and saline-treated (control) animals (n = 8). The excitability of aPVT neurons was assessed by injecting a series of depolarizing and hyperpolarizing current steps and characterizing the resulting action potential (AP) discharge properties. This analysis indicated that the majority of aPVT neurons exhibit tonic firing (TF), and initial bursting (IB) consistent with previous studies. However, we also identified PVT neurons that exhibited delayed firing (DF), single spiking (SS) and reluctant firing (RF) patterns. Interestingly, cocaine exposure significantly increased the proportion of aPVT neurons that exhibited TF. We then investigated the effects of CART on excitatory synaptic inputs to aPVT neurons. Application of CART significantly suppressed excitatory synaptic drive to PVT neurons in both cocaine-treated and control recordings. This finding is consistent with our previous behavioral data, which showed that CART signaling in the PVT negatively regulates drug-seeking behavior. Together, these studies suggest that cocaine

  5. The Effects of Direction of Exertion, Path, and Load Placement in Nursing Cart Pushing and Pulling Tasks: An Electromyographical Study.

    Science.gov (United States)

    Kao, Huei Chu; Lin, Chiuhsiang Joe; Lee, Yung Hui; Chen, Su Huang

    2015-01-01

    The purpose of this study was to explore the effects of direction of exertion (DOE) (pushing, pulling), path (walking in a straight line, turning left, walking uphill), and load placement (LP) (the 18 blocks were indicated by X, Y and Z axis; there were 3 levels on the X axis, 2 levels on the Y axis, and 3 levels on the Z axis) on muscle activity and ratings of perceived exertion in nursing cart pushing and pulling tasks. Ten participants who were female students and not experienced nurses were recruited to participate in the experiment. Each participant performed 108 experimental trials in the study, consisting of 2 directions of exertion (push and pull), 3 paths, and 18 load placements (indicated by X, Y and Z axes). A 23kg load was placed into one load placement. The dependent variables were electromyographic (EMG) data of four muscles collected bilaterally as follows: Left (L) and right (R) trapezius (TR), flexor digitorum superficialis (FDS), extensor digitorum (ED), and erector spinae (ES) and subjective ratings of perceived exertion (RPE). Split-split-plot ANOVA was conducted to analyze significant differences between DOE, path, and LP in the EMG and RPE data. Pulling cart tasks produced a significantly higher activation of the muscles (RTR:54.4%, LTR:50.3%, LFDS:57.0%, LED:63.4%, RES:40.7%, LES:36.7%) than pushing cart tasks (RTR:42.4%, LTR:35.1%, LFDS:32.3%, LED:55.1%, RES:33.3%, LES:32.1%). A significantly greater perceived exertion was found in pulling cart tasks than pushing cart tasks. Significantly higher activation of all muscles and perceived exertion were observed for walking uphill than walking in a straight line and turning left. Significantly lower muscle activity of all muscles and subject ratings were observed for the central position on the X axis, the bottom position on the Y axis, and the posterior position on the Z axis. These findings suggest that nursing staff should adopt forward pushing when moving a nursing cart, instead of backward

  6. The Effects of Direction of Exertion, Path, and Load Placement in Nursing Cart Pushing and Pulling Tasks: An Electromyographical Study.

    Directory of Open Access Journals (Sweden)

    Huei Chu Kao

    Full Text Available The purpose of this study was to explore the effects of direction of exertion (DOE (pushing, pulling, path (walking in a straight line, turning left, walking uphill, and load placement (LP (the 18 blocks were indicated by X, Y and Z axis; there were 3 levels on the X axis, 2 levels on the Y axis, and 3 levels on the Z axis on muscle activity and ratings of perceived exertion in nursing cart pushing and pulling tasks. Ten participants who were female students and not experienced nurses were recruited to participate in the experiment. Each participant performed 108 experimental trials in the study, consisting of 2 directions of exertion (push and pull, 3 paths, and 18 load placements (indicated by X, Y and Z axes. A 23kg load was placed into one load placement. The dependent variables were electromyographic (EMG data of four muscles collected bilaterally as follows: Left (L and right (R trapezius (TR, flexor digitorum superficialis (FDS, extensor digitorum (ED, and erector spinae (ES and subjective ratings of perceived exertion (RPE. Split-split-plot ANOVA was conducted to analyze significant differences between DOE, path, and LP in the EMG and RPE data. Pulling cart tasks produced a significantly higher activation of the muscles (RTR:54.4%, LTR:50.3%, LFDS:57.0%, LED:63.4%, RES:40.7%, LES:36.7% than pushing cart tasks (RTR:42.4%, LTR:35.1%, LFDS:32.3%, LED:55.1%, RES:33.3%, LES:32.1%. A significantly greater perceived exertion was found in pulling cart tasks than pushing cart tasks. Significantly higher activation of all muscles and perceived exertion were observed for walking uphill than walking in a straight line and turning left. Significantly lower muscle activity of all muscles and subject ratings were observed for the central position on the X axis, the bottom position on the Y axis, and the posterior position on the Z axis. These findings suggest that nursing staff should adopt forward pushing when moving a nursing cart, instead of

  7. Electrophysiological characteristics of paraventricular thalamic (PVT) neurons in response to cocaine and cocaine- and amphetamine-regulated transcript (CART)

    Science.gov (United States)

    Yeoh, Jiann Wei; James, Morgan H.; Graham, Brett A.; Dayas, Christopher V.

    2014-01-01

    Recent work has established that the paraventricular thalamus (PVT) is a central node in the brain reward-seeking pathway. This role is mediated in part through projections from hypothalamic peptide transmitter systems such as cocaine- and amphetamine-regulated transcript (CART). Consistent with this proposition, we previously found that inactivation of the PVT or infusions of CART into the PVT suppressed drug-seeking behavior in an animal model of contingent cocaine self-administration. Despite this work, few studies have assessed how the basic physiological properties of PVT neurons are influenced by exposure to drugs such as cocaine. Further, our previous work did not assess how infusions of CART, which we found to decrease cocaine-seeking, altered the activity of PVT neurons. In the current study we address these issues by recording from anterior PVT (aPVT) neurons in acutely prepared brain slices from cocaine-treated (15 mg/ml, n = 8) and saline-treated (control) animals (n = 8). The excitability of aPVT neurons was assessed by injecting a series of depolarizing and hyperpolarizing current steps and characterizing the resulting action potential (AP) discharge properties. This analysis indicated that the majority of aPVT neurons exhibit tonic firing (TF), and initial bursting (IB) consistent with previous studies. However, we also identified PVT neurons that exhibited delayed firing (DF), single spiking (SS) and reluctant firing (RF) patterns. Interestingly, cocaine exposure significantly increased the proportion of aPVT neurons that exhibited TF. We then investigated the effects of CART on excitatory synaptic inputs to aPVT neurons. Application of CART significantly suppressed excitatory synaptic drive to PVT neurons in both cocaine-treated and control recordings. This finding is consistent with our previous behavioral data, which showed that CART signaling in the PVT negatively regulates drug-seeking behavior. Together, these studies suggest that cocaine

  8. Porosity Prediction of Plain Weft Knitted Fabrics

    Directory of Open Access Journals (Sweden)

    Muhammad Owais Raza Siddiqui

    2014-12-01

    Full Text Available Wearing comfort of clothing is dependent on air permeability, moisture absorbency and wicking properties of fabric, which are related to the porosity of fabric. In this work, a plug-in is developed using Python script and incorporated in Abaqus/CAE for the prediction of porosity of plain weft knitted fabrics. The Plug-in is able to automatically generate 3D solid and multifilament weft knitted fabric models and accurately determine the porosity of fabrics in two steps. In this work, plain weft knitted fabrics made of monofilament, multifilament and spun yarn made of staple fibers were used to evaluate the effectiveness of the developed plug-in. In the case of staple fiber yarn, intra yarn porosity was considered in the calculation of porosity. The first step is to develop a 3D geometrical model of plain weft knitted fabric and the second step is to calculate the porosity of the fabric by using the geometrical parameter of 3D weft knitted fabric model generated in step one. The predicted porosity of plain weft knitted fabric is extracted in the second step and is displayed in the message area. The predicted results obtained from the plug-in have been compared with the experimental results obtained from previously developed models; they agreed well.

  9. The geologic story of the Great Plains

    Science.gov (United States)

    Trimble, Donald E.

    1980-01-01

    The Great Plains! The words alone create a sense of space and a feeling of destiny a challenge. But what exactly is this special part of Western America that contains so much of our history? How did it come to be? Why is it different?

  10. Pedogeographic regionalization of the Pomurje plain

    Directory of Open Access Journals (Sweden)

    Franc Lovrenčak

    1991-12-01

    Full Text Available The paper deals with the pedogeographic regionalization of the Pomurje plain (Northeast Slovenia. With regard to differences in parent material, landforms, and hydrographic characteristics, the soil cover is ranked into two pedogeographic regions. Each of them is furthermore divided into several subregions grouped together according to related soil groups.

  11. Great plains regional climate assessment technical report

    Science.gov (United States)

    The Great Plains region (GP) plays important role in providing food and energy to the economy of the United States. Multiple climatic and non-climatic stressors put multiple sectors, livelihoods and communities at risk, including agriculture, water, ecosystems and rural and tribal communities. The G...

  12. Later cART Initiation in Migrant Men from Sub-Saharan Africa without Advanced HIV Disease in France

    Science.gov (United States)

    de Monteynard, Laure-Amélie; Dray-Spira, Rosemary; de Truchis, Pierre; Grabar, Sophie; Launay, Odile; Meynard, Jean-Luc; Khuong-Josses, Marie-Aude; Gilquin, Jacques; Rey, David; Simon, Anne; Pavie, Juliette; Mahamat, Aba; Matheron, Sophie; Costagliola, Dominique; Abgrall, Sophie

    2015-01-01

    Objective To compare the time from entry into care for HIV infection until combination antiretroviral therapy (cART) initiation between migrants and non migrants in France, excluding late access to care. Methods Antiretroviral-naïve HIV-1-infected individuals newly enrolled in the FHDH cohort between 2002–2010, with CD4 cell counts >200/μL and no previous or current AIDS events were included. In three baseline CD4 cell count strata (200–349, 350-499, ≥500/μL), we examined the crude time until cART initiation within three years after enrolment according to geographic origin, and multivariable hazard ratios according to geographic origin, gender and HIV-transmission group, with adjustment for baseline age, enrolment period, region of care, plasma viral load, and HBV/HBC coinfection. Results Among 13338 individuals, 9605 (72.1%) were French natives (FRA), 2873 (21.4%) were migrants from sub-Saharan Africa/non-French West Indies (SSA/NFW), and 860 (6.5%) were migrants from other countries. Kaplan-Meier probabilities of cART initiation were significantly lower in SSA/NFW than in FRA individuals throughout the study period, regardless of the baseline CD4 stratum. After adjustment, the likelihood of cART initiation was respectively 15% (95%CI, 1–28) and 20% (95%CI, 2–38) lower in SSA/NFW men than in FRA men who had sex with men (MSM) in the 350-499 and ≥500 CD4 strata, while no difference was observed between other migrant groups and FRA MSM. Conclusion SSA/NFW migrant men living in France with CD4 >350/μL at entry into care are more likely to begin cART later than FRA MSM, despite free access to treatment. Administrative delays in obtaining healthcare coverage do not appear to be responsible. PMID:25734445

  13. Differences in CART expression and cell cycle behavior discriminate sympathetic neuroblast from chromaffin cell lineages in mouse sympathoadrenal cells.

    Science.gov (United States)

    Chan, Wing Hei; Gonsalvez, David G; Young, Heather M; Southard-Smith, E Michelle; Cane, Kylie N; Anderson, Colin R

    2016-02-01

    Adrenal medullary chromaffin cells and peripheral sympathetic neurons originate from a common sympathoadrenal (SA) progenitor cell. The timing and phenotypic changes that mark this lineage diversification are not fully understood. The present study investigated the expression patterns of phenotypic markers, and cell cycle dynamics, in the adrenal medulla and the neighboring suprarenal ganglion of embryonic mice. The noradrenergic marker, tyrosine hydroxylase (TH), was detected in both presumptive adrenal medulla and sympathetic ganglion cells, but with significantly stronger immunostaining in the former. There was intense cocaine and amphetamine-regulated transcript (CART) peptide immunostaining in most neuroblasts, whereas very few adrenal chromaffin cells showed detectable CART immunostaining. This phenotypic segregation appeared as early as E12.5, before anatomical segregation of the two cell types. Cell cycle dynamics were also examined. Initially, 88% of Sox10 positive (+) neural crest progenitors were proliferating at E10.5. Many SA progenitor cells withdrew from the cell cycle at E11.5 as they started to express TH. Whereas 70% of neuroblasts (TH+/CART+ cells) were back in the cell cycle at E12.5, only around 20% of chromaffin (CART negative) cells were in the cell cycle at E12.5 and subsequent days. Thus, chromaffin cell and neuroblast lineages showed differences in proliferative behavior from their earliest appearance. We conclude that the intensity of TH immunostaining and the expression of CART permit early discrimination of chromaffin cells and sympathetic neuroblasts, and that developing chromaffin cells exhibit significantly lower proliferative activity relative to sympathetic neuroblasts.

  14. Experiments to Determine Whether Recursive Partitioning (CART) or an Artificial Neural Network Overcomes Theoretical Limitations of Cox Proportional Hazards Regression

    Science.gov (United States)

    Kattan, Michael W.; Hess, Kenneth R.; Kattan, Michael W.

    1998-01-01

    New computationally intensive tools for medical survival analyses include recursive partitioning (also called CART) and artificial neural networks. A challenge that remains is to better understand the behavior of these techniques in effort to know when they will be effective tools. Theoretically they may overcome limitations of the traditional multivariable survival technique, the Cox proportional hazards regression model. Experiments were designed to test whether the new tools would, in practice, overcome these limitations. Two datasets in which theory suggests CART and the neural network should outperform the Cox model were selected. The first was a published leukemia dataset manipulated to have a strong interaction that CART should detect. The second was a published cirrhosis dataset with pronounced nonlinear effects that a neural network should fit. Repeated sampling of 50 training and testing subsets was applied to each technique. The concordance index C was calculated as a measure of predictive accuracy by each technique on the testing dataset. In the interaction dataset, CART outperformed Cox (P less than 0.05) with a C improvement of 0.1 (95% Cl, 0.08 to 0.12). In the nonlinear dataset, the neural network outperformed the Cox model (P less than 0.05), but by a very slight amount (0.015). As predicted by theory, CART and the neural network were able to overcome limitations of the Cox model. Experiments like these are important to increase our understanding of when one of these new techniques will outperform the standard Cox model. Further research is necessary to predict which technique will do best a priori and to assess the magnitude of superiority.

  15. 49 CFR 230.102 - Tender plain bearing journal boxes.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Tender plain bearing journal boxes. 230.102... Locomotives and Tenders Running Gear § 230.102 Tender plain bearing journal boxes. Plain bearing journal boxes... expected to damage the bearing; or have a detrimental effect on the lubrication of the journal and...

  16. Development of Prediction Model for Endocrine Disorders in the Korean Elderly Using CART Algorithm

    Directory of Open Access Journals (Sweden)

    Haewon Byeon

    2015-09-01

    Full Text Available The aim of the present cross-sectional study was to analyze the factors that affect endocrine disorders in the Korean elderly. The data were taken from the A Study of the Seoul Welfare Panel Study 2010. The subjects were 2111 people (879 males, 1,232 females aged 60 and older living in the community. The dependent variable was defined as the prevalence of endocrine disorders. The explanatory variables were gender, level of education, household income, employment status, marital status, drinking, smoking, BMI, subjective health status, physical activity, experience of stress, and depression. In the Classification and Regression Tree (CART algorithm analysis, subjective health status, BMI, education level, and household income were significantly associated with endocrine disorders in the Korean elderly. The most preferentially involved predictor was subjective health status. The development of guidelines and health education to prevent endocrine disorders is required for taking multiple risk factors into account.

  17. Monocytes as Regulators of Inflammation and HIV-Related Comorbidities during cART

    Science.gov (United States)

    Anzinger, Joshua J.; Butterfield, Tiffany R.; Angelovich, Thomas A.; Crowe, Suzanne M.; Palmer, Clovis S.

    2014-01-01

    Combined antiretroviral therapy (cART) extends the lifespan and the quality of life for HIV-infected persons but does not completely eliminate chronic immune activation and inflammation. The low level of chronic immune activation persisting during cART-treated HIV infection is associated with the development of diseases which usually occur in the elderly. Although T-cell activation has been extensively examined in the context of cART-treated HIV infection, monocyte activation is only beginning to be recognized as an important source of inflammation in this context. Here we examine markers and sources of monocyte activation during cART-treated HIV infection and discuss the role of monocytes during cardiovascular disease, HIV-associated neurocognitive disorder, and innate immune aging. PMID:25025081

  18. Monocytes as Regulators of Inflammation and HIV-Related Comorbidities during cART

    Directory of Open Access Journals (Sweden)

    Joshua J. Anzinger

    2014-01-01

    Full Text Available Combined antiretroviral therapy (cART extends the lifespan and the quality of life for HIV-infected persons but does not completely eliminate chronic immune activation and inflammation. The low level of chronic immune activation persisting during cART-treated HIV infection is associated with the development of diseases which usually occur in the elderly. Although T-cell activation has been extensively examined in the context of cART-treated HIV infection, monocyte activation is only beginning to be recognized as an important source of inflammation in this context. Here we examine markers and sources of monocyte activation during cART-treated HIV infection and discuss the role of monocytes during cardiovascular disease, HIV-associated neurocognitive disorder, and innate immune aging.

  19. Feeding a sustainable chemical industry: do we have the bioproducts cart before the feedstocks horse?

    Science.gov (United States)

    Dale, Bruce E

    2017-07-20

    A sustainable chemical industry cannot exist at scale without both sustainable feedstocks and feedstock supply chains to provide the raw materials. However, most current research focus is on producing the sustainable chemicals and materials. Little attention is given to how and by whom sustainable feedstocks will be supplied. In effect, we have put the bioproducts cart before the sustainable feedstocks horse. For example, bulky, unstable, non-commodity feedstocks such as crop residues probably cannot supply a large-scale sustainable industry. Likewise, those who manage land to produce feedstocks must benefit significantly from feedstock production, otherwise they will not participate in this industry and it will never grow. However, given real markets that properly reward farmers, demand for sustainable bioproducts and bioenergy can drive the adoption of more sustainable agricultural and forestry practices, providing many societal "win-win" opportunities. Three case studies are presented to show how this "win-win" process might unfold.

  20. Indoor space 3D visual reconstruction using mobile cart with laser scanner and cameras

    Science.gov (United States)

    Gashongore, Prince Dukundane; Kawasue, Kikuhito; Yoshida, Kumiko; Aoki, Ryota

    2017-02-01

    Indoor space 3D visual reconstruction has many applications and, once done accurately, it enables people to conduct different indoor activities in an efficient manner. For example, an effective and efficient emergency rescue response can be accomplished in a fire disaster situation by using 3D visual information of a destroyed building. Therefore, an accurate Indoor Space 3D visual reconstruction system which can be operated in any given environment without GPS has been developed using a Human-Operated mobile cart equipped with a laser scanner, CCD camera, omnidirectional camera and a computer. By using the system, accurate indoor 3D Visual Data is reconstructed automatically. The obtained 3D data can be used for rescue operations, guiding blind or partially sighted persons and so forth.

  1. The Impact of Groupement des Cartes Bancaires on Competition Law Enforcement

    Directory of Open Access Journals (Sweden)

    Piero Fattori

    2015-10-01

    Full Text Available The Groupement des Cartes bancaires represents a key judgment for competition enforcement, as it provides helpful clarification on the notion of “restriction by object” and on the judicial standard of review of Commission decisions. As of the first aspect, the ruling limited the restrictions by object to those which by their very nature and on the basis of the experience reveal a sufficient degree of harm to competition. On the standard required to the Court in reviewing competition decisions, the ECJ underlines the necessity of carrying out a full review, specifying that the presence of economic issues should not dispense the Court with an in-depth review of the law and the facts. The principles expressed in the judgment could have a great impact also at national level, where it could provide useful guidance both to Italian competition authority and to the Administrative Courts.

  2. Analysis of sequence variability in the pig CART gene and association of polymorphism with fatness traits in a F2 population.

    Science.gov (United States)

    Zhu, Xiaoping; Mo, Delin; Wang, Chong; Liu, Xiaohong; Li, Jiaqi; Ling, Fei; Chen, Yaosheng

    2014-08-01

    CART (cocaine- and amphetamine-regulated transcript) peptides are neuromodulators that are involved in appetite control and energy homeostasis. It can inhibit food intake and reduce body weight that have received much attention, but a direct and comprehensive relationship with pigs differing in fatness which could be applied to breeding well has not been established. This study aims to search for polymorphism within the porcine CART gene and evaluate the effect of specific genotypes with regards to an association with fatness traits in a F2 population consisting of 230 individuals. Screening of 2264 bp DNA fragment covering the entire CART gene revealed 29 mutations and four indels (insertion or a deletion), in which four unlinked SNPs (single-nucleotide polymorphisms) could be digested by enzymes and subsequently genotyped in two purebreds and a F2 population. Landrace (lean-type), one of purebreds, presented significantly higher CART expression level than Lantang (obese-type) in most tissues studied. Association analysis revealed that three SNPs (T415C, C640T and C847T) displayed significantly association (p CART expression among individuals with different genotypes, and the individuals with lower average live backfat thickness (BFAW) expressed CART protein at a bit higher level than others. Our study screened and mapped the genetic variations in the porcine CART gene, and confirmed three functional SNPs which are promising molecular markers for pig production traits.

  3. Projection patterns of lateral hypothalamic, cocaine- and amphetamine-regulated transcript (CART) neurons to the dorsal raphe and/or the locus coeruleus in the rat.

    Science.gov (United States)

    Yoon, Ye S; Lee, Hyun S

    2013-02-04

    The present study was designed to reveal the projection patterns of lateral hypothalamic (LH), cocaine- and amphetamine-regulated transcript (CART) neurons to the dorsal raphe (DR) and/or the locus coeruleus (LC) in the rat. After the injection of Red or Green Retrobeads into the DR or LC, LH sections were immunostained for CART and/or melanin-concentrating hormone (MCH). First, CART-immunoreactive axon terminals formed close appositions to the DR (or LC) neuronal profiles. Second, a subpopulation of CART neurons containing MCH projected to the monoaminergic nuclei; the majority of labeled neurons were observed in the dorsal hypothalamic area, the dorsal part of the posterior hypothalamic area, and the zona incerta. Cells were also observed in the perifornical part of the LH, the dorsomedial hypothalamic nucleus, the peduncular and the magnocellular parts of the LH. Of the total population of DR (or LC)-projecting cells, CART/MCH co-containing neurons were 9.5% ± 1.6% (or 10.8% ± 1.3% for LC). Finally, a subset of CART (or MCH) neurons provided divergent axon collaterals to the DR and the LC. Of the entire CART (or MCH) cell population, 3.9% ± 0.8% (or 5.6% ± 1.0% for MCH) sent axon collaterals to the DR/LC. CART/MCH co-containing neurons projecting to the DR or LC might be involved in the feeding-related regulation of arousal, stress-related responses, and emotional behaviors. Thus, CART (or MCH) cells that send divergent axon collaterals to the DR/LC might have a simultaneous (and possibly more efficient) way to exert their specific influences on the aminergic nuclei.

  4. Effect of desipramine and citalopram treatment on forced swimming test-induced changes in cocaine- and amphetamine-regulated transcript (CART) immunoreactivity in mice.

    Science.gov (United States)

    Chung, Sung; Kim, Hee Jeong; Kim, Hyun Ju; Choi, Sun Hye; Kim, Jin Wook; Kim, Jeong Min; Shin, Kyung Ho

    2014-05-01

    Recent study demonstrates antidepressant-like effect of cocaine- and amphetamine-regulated transcript (CART) in the forced swimming test (FST), but less is known about whether antidepressant treatments alter levels of CART immunoreactivity (CART-IR) in the FST. To explore this possibility, we assessed the treatment effects of desipramine and citalopram, which inhibit the reuptake of norepinephrine and serotonin into the presynaptic terminals, respectively, on changes in levels of CART-IR before and after the test swim in mouse brain. Levels of CART-IR in the nucleus accumbens shell (AcbSh), dorsal bed nucleus of the stria terminalis (dBNST), and hypothalamic paraventricular nucleus (PVN) were significantly increased before the test swim by desipramine and citalopram treatments. This increase in CART-IR in the AcbSh, dBNST, and PVN before the test swim remained elevated by desipramine treatment after the test swim, but this increase in these brain areas returned to near control levels after test swim by citalopram treatment. Citalopram, but not desipramine, treatment increased levels of CART-IR in the central nucleus of the amygdala (CeA) and the locus ceruleus (LC) before the test swim, and this increase was returned to control levels after the test swim in the CeA, but not in the LC. These results suggest common and distinct regulation of CART by desipramine and citalopram treatments in the FST and raise the possibility that CART in the AcbSh, dBNST, and CeA may be involved in antidepressant-like effect in the FST.

  5. Corticotropin-releasing hormone (CRH) stimulates cocaine- and amphetamine-regulated transcript gene (CART1) expression through CRH type 1 receptor (CRHR1) in chicken anterior pituitary.

    Science.gov (United States)

    Mo, Chunheng; Cai, Guoqing; Huang, Long; Deng, Qiuyang; Lin, Dongliang; Cui, Lin; Wang, Yajun; Li, Juan

    2015-12-01

    Cocaine- and amphetamine-regulated transcript (CART) peptide(s) is generally viewed as neuropeptide(s) and can control food intake in vertebrates, however, our recent study revealed that CART1 peptide is predominantly expressed in chicken anterior pituitary, suggesting that cCART1 peptide is a novel pituitary hormone in chickens and its expression is likely controlled by hypothalamic factor(s). To test this hypothesis, in this study, we examined the spatial expression of CART1 in chicken anterior pituitary and investigated the effect of hypothalamic corticotropin-releasing hormone (CRH) on pituitary cCART1 expression. The results showed that: 1) CART1 is expressed in both caudal and cephalic lobes of chicken anterior pituitary, revealed by quantitative real-time PCR (qPCR), western blot and immuno-histochemical staining; 2) CRH potently stimulates cCART1 mRNA expression in cultured chick pituitary cells, as examined by qPCR, and this effect is blocked by CP154526 (and not K41498), an antagonist specific for chicken CRH type I receptor (cCRHR1), suggesting that cCRHR1 expressed on corticotrophs mediates this action; 3) the stimulatory effect of CRH on pituitary cCART1 expression is inhibited by pharmacological drugs targeting the intracellular AC/cAMP/PKA, PLC/IP3/Ca(2+), and MEK/ERK signaling pathways. This finding, together with the functional coupling of these signaling pathways to cCRHR1 expressed in CHO cells demonstrated by luciferase reporter assay systems, indicates that these intracellular signaling pathways coupled to cCRHR1 can mediate CRH action. Collectively, our present study offers the first substantial evidence that hypothalamic CRH can stimulate pituitary CART1 expression via activation of CRHR1 in a vertebrate species.

  6. Actual use of and satisfaction associated with rollators and "shopping carts" among frail elderly Japanese people using day-service facilities.

    Science.gov (United States)

    Kitajima, Eiji; Moriuchi, Takefumi; Iso, Naoki; Sagari, Akira; Kikuchi, Yasuyuki; Higashi, Toshio

    2017-07-01

    Purpose This study aimed at clarifying the actual use of and satisfaction with rollators and "shopping carts" (wheeled walkers with storage) among frail elderly people, who were certified by a long-term care insurance system as users of facilities that provide day-service nursing care and rehabilitation. Methods We identified 1247 frail elderly people who used day-service facilities, and evaluated their actual use of, and satisfaction with, rollators and shopping carts. Results Forty-four (3.5%) individuals used rollators, and 53 (4.3%) used shopping carts. The shopping cart group contained more individuals who were certified as care level 1 (26.4%), than the rollator group (20.5%), and 52.8% of the shopping cart group was certified as care levels 1-3. The scores for "repairs and services" and "follow-up" from the Quebec User Evaluation of Satisfaction with assistive Technology second version (QUEST 2.0) survey were significantly higher in the rollator group than in the shopping cart group. Conclusions The QUEST 2.0 scores revealed that shopping cart users exhibit insufficient "repairs and services" and "follow-up" scores. As frail elderly people with poor care status accounted for >50% of the shopping cart group, these individuals urgently need walking aids that are tailored to their care status. Implications for Rehabilitation We conclude that walking aid fitting must be tailored to each persons care status, and suggest that a system should be established to allow occupational or physical therapists to provide this fitting Moreover, our analysis of the QUEST2.0 service scores revealed that repairs, services, and follow-up are insufficient to meet the needs of shopping cart users.

  7. Metal concentrations in the groundwater in Birjand flood plain, Iran.

    Science.gov (United States)

    Mansouri, Borhan; Salehi, Javad; Etebari, Behrooz; Moghaddam, Hamid Kardan

    2012-07-01

    The objective of the present study was to investigate the concentration of metals (cadmium, lead, chromium, zinc, copper, and iron) were measured in groundwater at 30 sites from the Birjand flood plain of eastern Iran during the November 2010; identify any relationships between metals and pH, total hardness. Metal concentrations in the groundwater samples were decreased in sequence of Zn > Fe > Cu > Cr > Pb > Cd, respectively. The results showed that the overall mean concentrations of Cd, Pb, and Cr were at 0.000, 0.023, and 0.049 mg l(-1), respectively. The mean concentration of Cu, Zn, and Fe were 0.109, 0.192, and 0.174 mg l(-1), respectively. Results also indicated that there were correlations among Cd, Cu, and Zn metals.

  8. Environmental Implication of Intensive Farming Practices on North China Plain

    Institute of Scientific and Technical Information of China (English)

    Zhen Lin; Zhou Hailin; Xie Gaodi

    2005-01-01

    The current pressure on production resources of North China Plain, such as land and water to feed the growing population, necessitates the assessment of the sustainability of farming practices. This study focuses on the sustainability of farming practices related to groundwater and soil fertility management. The assessment is based on selected site-specific key indicators and their established threshold limits. The current farming practices in the study area are clearly unsustainable.Only about 6% of the surveyed farm households practice sustainable farming. The study stresses that farming practice, which is economically sustainable,should not be promoted at the cost of environment.Holistic strategies need to be developed and implemented that aim at balanced use of inputs,which satisfy both productivity and environmental concerns.

  9. Geomorphological development of Eastern Mongolian plain, Mongolia

    Science.gov (United States)

    khukhuudei, Ulambadrakh; otgonbayar, Orolzodmaa

    2016-04-01

    Several summaries and investigations of the geomorphological description and feature for Eastern Mongolian plain (EMP), the one of the largest geomorphological district, fully covering east side of Mongolia (Murzayev, 1949; Vlodavets, 1950, 1955; Marinov, Khasin, 1954; Marinov, 1966; Nikolayeva, 1971; Selivanov, 1972; Chichagov, 1974, 1976; Grigorov, 1975; Korjuyev, 1982; Syirnev, 1982, 1984) had been publishing continuously. But literature for geomorphology of EMP have been not appeared during over the past 20 years. However, we re-combine the geomorphological development of EMP, according to the results of many publications for surrounding regions of Russia and China and unpublished maps. Main morphology of EMP has the plain, containing with aeolian, fluvial and lacustrine landforms. Plain morphology defined that denudation plains to North Kherlen, South Kherlen, Baruun Urt, Uulbayan, Delgerekh and other which developed on the Paleozoic rocks, layered plain to Choibalsan, Tamsag, Ongon, Gert, Sumiin nuur and Torey- on the Late Cretaceous and Neogene sediments and accumulation plain with alluvial and lacustrine origin such as Menen, Buir nuur, Tamsagbulag, Khalzan and other. These plains of EMP related with tectonics and structure of region and inherited the development of the Mesozoic, particularly Late Mesozoic structure. Large basins of EMP are Tamsag, Choibalsan and Torey and other small basins - from 7-10 km to 25-30 km width and rather a several 10 km extend, cutting a basement. The origin of plain morphology for EMP is interpreted as two main stages of the geomorphological development model, based on geology. In first stage or Late Jurassic (?) - Lower Cretaceous period, there was developed rift basin, then, in second stage or since Late Cretaceous period, plain morphology originated from the intermountain basin that dominated by exogenic process and kept in current EMP area. Data relevant to the development history of EMP are following. 1. Rift volcanism

  10. Proyecto de estudio y experimentación del cartón corrugado para su posterior inserción en el mercado

    OpenAIRE

    Cabrera Chiriboga, Alfredo Cabrera

    2009-01-01

    Contiene: Ecodiseño. Aspectos Ambientales de un producto. El ciclo de vida de un Producto. El Ecodiseño en el proceso de desarrollo de productos. Beneficios del Ecodiseño. El Reciclaje. Proceso de producción del cartón corrugado. El grupo simple cara (cara sencilla). Circuito del papel de ondular. Circuito de las caras. El grupo doble cara (o triple). Propiedades del cartón corrugado. Perfil de la onda o canal. Clasificación de los cartones. Exigencias en la fabricación del cartón corrugado. ...

  11. Classification and regression tree (CART analyses of genomic signatures reveal sets of tetramers that discriminate temperature optima of archaea and bacteria

    Directory of Open Access Journals (Sweden)

    Betsey Dexter Dyer

    2008-01-01

    Full Text Available Classification and regression tree (CART analysis was applied to genome-wide tetranucleotide frequencies (genomic signatures of 195 archaea and bacteria. Although genomic signatures have typically been used to classify evolutionary divergence, in this study, convergent evolution was the focus. Temperature optima for most of the organisms examined could be distinguished by CART analyses of tetranucleotide frequencies. This suggests that pervasive (nonlinear qualities of genomes may reflect certain environmental conditions (such as temperature in which those genomes evolved. The predominant use of GAGA and AGGA as the discriminating tetramers in CART models suggests that purine-loading and codon biases of thermophiles may explain some of the results.

  12. Shatter cones in Illinois: Evidence for metoeritic impacts at Glasford and Des Plaines

    Science.gov (United States)

    Mchone, John F.; Sargent, Michael L.; Nelson, W. John

    1987-01-01

    Shatter cone fragments were recovered from rock cores at two previously suspected, but heretofore unverified, impact structures in Illinois. Both sites are buried features known from geophysical surveys and drill holes. Shatter cones are accepted widely as field criteria of meteoritic impact. Detection of these shock indicators in both the Glasford Structure and the Des Plains Disturbance upgrades these sites in Earth's inventory of known and suspected impact structures from possible impact sites with compatible structure and morphology to probable impact structures which possess also evidence of shock metamorphism.

  13. Late Pleistocene dune activity in the central Great Plains, USA

    Science.gov (United States)

    Mason, J.A.; Swinehart, J.B.; Hanson, P.R.; Loope, D.B.; Goble, R.J.; Miao, X.; Schmeisser, R.L.

    2011-01-01

    Stabilized dunes of the central Great Plains, especially the megabarchans and large barchanoid ridges of the Nebraska Sand Hills, provide dramatic evidence of late Quaternary environmental change. Episodic Holocene dune activity in this region is now well-documented, but Late Pleistocene dune mobility has remained poorly documented, despite early interpretations of the Sand Hills dunes as Pleistocene relicts. New optically stimulated luminescence (OSL) ages from drill cores and outcrops provide evidence of Late Pleistocene dune activity at sites distributed across the central Great Plains. In addition, Late Pleistocene eolian sands deposited at 20-25 ka are interbedded with loess south of the Sand Hills. Several of the large dunes sampled in the Sand Hills clearly contain a substantial core of Late Pleistocene sand; thus, they had developed by the Late Pleistocene and were fully mobile at that time, although substantial sand deposition and extensive longitudinal dune construction occurred during the Holocene. Many of the Late Pleistocene OSL ages fall between 17 and 14 ka, but it is likely that these ages represent only the later part of a longer period of dune construction and migration. At several sites, significant Late Pleistocene or Holocene large-dune migration also probably occurred after the time represented by the Pleistocene OSL ages. Sedimentary structures in Late Pleistocene eolian sand and the forms of large dunes potentially constructed in the Late Pleistocene both indicate sand transport dominated by northerly to westerly winds, consistent with Late Pleistocene loess transport directions. Numerical modeling of the climate of the Last Glacial Maximum has often yielded mean monthly surface winds southwest of the Laurentide Ice Sheet that are consistent with this geologic evidence, despite strengthened anticyclonic circulation over the ice sheet. Mobility of large dunes during the Late Pleistocene on the central Great Plains may have been the result of

  14. Change of ancient hydrology net in Northeast China Plain

    Institute of Scientific and Technical Information of China (English)

    Hui QU; Yu CHU; Fenglong ZHANG; Fuli QI; Xiangkui YANG

    2006-01-01

    Comparing with lithofacies palaeogeography of several great plains, the authors analyzed four great plains in Quaternary diastrophism, the sedimentary facies, sedimentary environment and their evolution from the independent embryonic and river system of ancient Heilongjiang finally to the Halar highland, Songnen Plain, Sanjiang Plain, the Xingkai Lake Plain and various river systems, collected the unification outside the system of Heilongjiang River to release into the sea, south ancient Xialiao River finally piracy Dongliao River, Xialiao River had released into the sea the ancient water law vicissitude and the evolved rule.

  15. Spatial Soil Temperature and Moisture Monitoring Across the Transylvanian Plain, in Romania

    Science.gov (United States)

    Rusu, Teodor; Weindorf, David; Haggard, Beatrix; Moraru, Paula Ioana; Sopterean, Mara Lucia

    2011-01-01

    The Transylvanian Plain, Romania is an important region for agronomic productivity. However, limited soils data and adoption of best management practices hinder land productivity. Soil temperatures of the Transylvanian Plain were evaluated using a set of twenty datalogging stations positioned throughout the plain. Soil temperatures were monitored at the surface and at 10, 30, and 50 cm depths, and soil moisture was monitored at 10 cm. Preliminary results indicate that most soils of the Transylvanian Plain will have a mesic temperature regime. However, differences in seasonal warming and cooling trends across the plain were noted. These have important implications for planting recommendations. Growing degree days (GDDs) are preferred over maturity ratings, because they can account for temperature anomalies. The crop being considered for this study was corn. The base temperature (BT) was set at 10oC, and the upper threshold was 30oC. Two methods were used to calculate GDDs; 1) minimum and maximum daily temperatures, and 2) 24 h of averaged temperature data. Growing degree days were run from 110-199 day of year (DOY) to represent approximate planting date to tasseling. The DOY that 694 accumulated growing degree days (AGDDs) was reached at each site was then analyzed to identify differences across the TP. Three sites failed to reach 694 AGDDs by DOY 199, and were excluded from comparisons to other results. Averaged values were used to create spline interpolation maps with ArcMap 9.2 (ESRI, Redlands, CA, USA). The southeastern portion of the TP was found to tassel a month earlier assuming a planting date of 109 DOY. Four DeKalb® corn hybrids were then selected based on GDDs to tasseling, drydown, drought tolerance, and insect resistance. With a better understanding of the GDD trends across the TP, more effective planting and harvesting could be accomplished by Romanian farmers to maximize agronomic production.

  16. Geologic Map of the Santa Barbara Coastal Plain Area, Santa Barbara County, California

    Science.gov (United States)

    Minor, Scott A.; Kellogg, Karl S.; Stanley, Richard G.; Gurrola, Larry D.; Keller, Edward A.; Brandt, Theodore R.

    2009-01-01

    This report presents a newly revised and expanded digital geologic map of the Santa Barbara coastal plain area at a compilation scale of 1:24,000 (one inch on the map to 2,000 feet on the ground)1 and with a horizontal positional accuracy of at least 20 m. The map depicts the distribution of bedrock units and surficial deposits and associated deformation underlying and adjacent to the coastal plain within the contiguous Dos Pueblos Canyon, Goleta, Santa Barbara, and Carpinteria 7.5' quadrangles. The new map supersedes an earlier preliminary geologic map of the central part of the coastal plain (Minor and others, 2002; revised 2006) that provided coastal coverage only within the Goleta and Santa Barbara quadrangles. In addition to new mapping to the west and east, geologic mapping in parts of the central map area has been significantly revised from the preliminary map compilation - especially north of downtown Santa Barbara in the Mission Ridge area - based on new structural interpretations supplemented by new biostratigraphic data. All surficial and bedrock map units, including several new units recognized in the areas of expanded mapping, are described in detail in the accompanying pamphlet. Abundant new biostratigraphic and biochronologic data based on microfossil identifications are presented in expanded unit descriptions of the marine Neogene Monterey and Sisquoc Formations. Site-specific fault kinematic observations embedded in the digital map database are more complete owing to the addition of slip-sense determinations. Finally, the pamphlet accompanying the present report includes an expanded and refined summary of stratigraphic and structural observations and interpretations that are based on the composite geologic data contained in the new map compilation. The Santa Barbara coastal plain is located in the western Transverse Ranges physiographic province along an east-west-trending segment of the southern California coastline about 100 km (62 mi) northwest

  17. Investigating organic micropollutants in a peri-urban flood plain aquifer

    OpenAIRE

    Manamsa, Katya; Lapworth, Dan; Stuart, Marianne

    2011-01-01

    This poster describes a pilot study to develop the sampling methodology required to investigate the occurrence and distribution of “emerging organic contaminants” in groundwater in an area of anticipated contamination. The study site was the BGS Oxford Observatory on the Port Meadow, within a peri-urban setting, including an area of ancient grassland on the gravels of the flood plain of the River Thames to the northwest of Oxford. Groundwater levels suggest that the regional groundwater flow ...

  18. Distribution of breeding shorebirds on the Arctic Coastal Plain of Alaska

    Science.gov (United States)

    Johnson, J.A.; Lanctot, Richard B.; Andres, B.A.; Bart, J.R.; Brown, S.C.; Kendall, S.J.; Payer, David C.

    2007-01-01

    Available information on the distribution of breeding shorebirds across the Arctic Coastal Plain of Alaska is dated, fragmented, and limited in scope. Herein, we describe the distribution of 19 shorebird species from data gathered at 407 study plots between 1998 and 2004. This information was collected using a single-visit rapid area search technique during territory establishment and early incubation periods, a time when social displays and vocalizations make the birds highly detectable. We describe the presence or absence of each species, as well as overall numbers of species, providing a regional perspective on shorebird distribution. We compare and contrast our shorebird distribution maps to those of prior studies and describe prominent patterns of shorebird distribution. Our examination of how shorebird distribution and numbers of species varied both latitudinally and longitudinally across the Arctic Coastal Plain of Alaska indicated that most shorebird species occur more frequently in the Beaufort Coastal Plain ecoregion (i.e., closer to the coast) than in the Brooks Foothills ecoregion (i.e., farther inland). Furthermore, the occurrence of several species indicated substantial longitudinal directionality. Species richness at surveyed sites was highest in the western portion of the Beaufort Coastal Plain ecoregion. The broad-scale distribution information we present here is valuable for evaluating potential effects of human development and climate change on Arctic-breeding shorebird populations. ?? The Arctic Institute of North America.

  19. Estimating Groundwater Development area in Jianan Plain using Standardized Groundwater Index

    Science.gov (United States)

    Yu, Chang Hsiang; Haw, Lee Cheng

    2017-04-01

    Taiwan has been facing severe water crises in recent years owing to the effects of extreme weather conditions. Changes in precipitation patterns have also made the drought phenomenon increasingly prominent, which has indirectly affected groundwater recharge. Hence, in the present study, long-term monitoring data were collected from the study area of the Jianan plain. The standardized groundwater index (SGI) and was then used to analyse the region's drought characteristics. To analyse the groundwater level by using SGI, making SGI180 groundwater level be the medium water crises, and SGI360 groundwater level be the extreme water crises. Through the different water crises signal in SGI180 and SGI360, we divide groundwater in Jianan plain into two sections. Thereby the water crises indicators establishing groundwater level standard line in Jianan Plain, then using the groundwater level standard line to find the study area where could be groundwater development area in Jianan plain. Taking into account relatively more water scarcity in dry season, so the study screen out another emergency backup groundwater development area, but the long-term groundwater development area is still as a priority development area. After finding suitable locations, groundwater modeling systems(GMS) software is used to simulate our sites to evaluate development volume. Finally, the result of study will help the government to grasp the water shortage situation immediately and solve the problem of water resources deployment.

  20. High incidence of intermittent care in HIV-1-infected patients in Curaçao before and after starting cART.

    Science.gov (United States)

    Hermanides, H S; Holman, R; Gras, L; Winkel, C N; Gerstenbluth, I; de Wolf, F; Duits, A J

    2013-01-01

    Retention in care is one of the major challenges to scaling up and maximizing the effectiveness of combination antiretroviral therapy (cART). High attrition rates have been reported in the Caribbean region, varying from 6% to 23%. We studied the incidence of and risk factors for intermittent care in a cohort of adult HIV-1-positive patients, who entered into care in Curaçao between January 2005 and July 2009. A total of 214 therapy-naïve HIV-1-infected patients aged 15 years or older, entered HIV care between January 2005 and July 2009. Intermittent care was defined as at least one period of 365 days or longer in which there was no HIV care contact in Curaçao. Cox regression models were used to identify characteristics associated with time to intermittent care. In all, 203 (95%) patients could be classified as having intermittent or continuous care. The incidence of intermittent care before starting cART was 25.4 per 100 person years observation (PYO), whilst it was 6.1 per 100 PYO after starting cART. Being born outside Curaçao was associated with intermittent care before and after starting cART. Time from diagnosis to entry into care was an independent predictor for intermittent care before starting cART. Younger age was independently associated with intermittent care after starting cART. Half of the patients returned to care after intermitting care. Upon returning to care, median CD4 count was 264 cells/mm(3) (IQR, 189-401) for those who intermitted care before starting cART, and 146 cells/mm(3) (IQR, 73-436) in those who intermitted care after starting cART. In conclusion, the incidence of intermitting care is high in Curaçao, especially before starting cART, and intermitting care before starting cART is an independent predictor for starting cART late.

  1. Lecture matérialiste des Méditations cartésiennes

    Directory of Open Access Journals (Sweden)

    Anne Staquet

    2009-08-01

    Full Text Available Lorsque, à de rares occasions, on envisage le caractère matérialiste de la pensée cartésienne, c'est systématiquement en s'appuyant sur ses textes scientifiques. Les textes plus philosophiques sont dans cette perspective laissés de côté, voire déconsidérés comme le montre de manière exacerbée  Hiram Caton, qui discrédite les Méditations sous prétexte qu'elle ne seraient écrites que pour endormir la censure et acheter une réputation à leur auteur et n'ont donc aucune pertinence philosophique. Or, Descartes n'a cessé d'insister sur l'importance de relier ses deux types écrits : les plus scientifiques et les plus métaphysiques. C'est la raison pour laquelle, à l'inverse de ces considérations, je propose de tenter une lecture matérialiste (au sens leibnizien du terme des Méditations métaphysiques. Pour ce faire, m'appuyant sur les paroles mêmes de Descartes, je commencerai par montrer l'usage que fait le philosophe de la dissimulation dans l'ensemble de ses œuvres. Je montrerai ensuite comment le dualisme cartésien permet de fonder un matérialisme. Et je terminerai en montrant comment les preuves de l'existence de Dieu et la distinction âme-corps ne contredisent en fait pas réellement une lecture matérialiste des Méditations cartésiennes.Materialistic interpretation of the Cartesian MéditationsWhen, on rare occasions, we consider the materialistic nature of the Cartesian thinking, we systematically refer to scientific texts. In this perspective, more philosophical texts are not taken into consideration or are even ignored, as Hiram Caton showed it by discrediting the Méditations because they would only have been written to dupe the censure and buy a reputation for their author. They would therefore have no philosphical pertinence at all. But Descartes never stopped to insist on the importance of combining both writing types: the scientific one and the metaphysical one. For that reason, contrary to these

  2. Winter Activity of Coastal Plain Populations of Bat Species Affected by White-Nose Syndrome and Wind Energy Facilities.

    Science.gov (United States)

    Grider, John F; Larsen, Angela L; Homyack, Jessica A; Kalcounis-Rueppell, Matina C

    2016-01-01

    Across the entire distribution of a species, populations may have variable responses to environmental perturbations. Many bat species experience mortality in large portions of their range during hibernation and along migratory paths to and from wintering grounds, from White-nose syndrome (WNS) and wind energy development, respectively. In some areas, warm temperatures may allow bats to remain active through winter, thus decreasing their susceptibility to WNS and/or mortality associated with migration to wintering grounds. These areas could act as a refugia and be important for the persistence of local populations. To determine if warmer temperatures affect bat activity, we compared year-round activity of bat populations in the Coastal Plain and Piedmont of North Carolina, USA, two regions that differ in winter temperature. We established six recording stations, four along a 295-kilometer north-south transect in the Coastal Plain, and two in the Piedmont of North Carolina. We recorded bat activity over two years. We supplemented our recordings with mist-net data. Although bat activity was lower during winter at all sites, the odds of recording a bat during winter were higher at Coastal Plain sites when compared with Piedmont sites. Further, bats in the Piedmont had a lower level of winter activity compared to summer activity than bats in the Coastal Plain that had more similar levels of activity in the winter and summer. We found high bat species richness on the Coastal Plain in winter, with winter-active species including those known to hibernate throughout most of their range and others known to be long distance migrants. In particular, two species impacted by WNS, the northern long-eared bat (Myotis septentrionalis) and tricolored bat (Perimyotis subflavus), were present year round in the Coastal Plain. The tricolored bat was also present year-round in the Piedmont. In the Coastal Plain, the long distance migratory hoary bat (Lasiurus cinereus) was active in the

  3. Spatial distribution of populations of solitarious adult desert locust (Schistocerca gregaria Forsk.) on the coastal plain of Sudan

    NARCIS (Netherlands)

    Woldewahid, G.; Werf, van der W.; Huis, van A.; Stein, A.

    2004-01-01

    1 Densities of solitarious adult desert locusts were measured on regular grids of up to 126 sample sites in the southern part of the coastal plain of Sudan during the winters of 1999/2000 and 2000/2001. Geostatistical procedures were used to characterize spatial dependence of locust density, to eval

  4. Impact of sedimentation in the Dommel flood plain on heavy metal availability and bioaccumulation in flora and fauna

    NARCIS (Netherlands)

    Vink, J.; Klaver, G.; Joziasse, J.

    2007-01-01

    This report describes the application of the BioChem-DSS, being developed in the EU KP6-programme AquaTerra, BASIN R3 work package, with the aim to assist in the definition and improvement of management options for the Meuse region. A case study was carried out in a flood plain site of the river Dom

  5. Hydrologic, Water-Quality, and Biological Data for Three Water Bodies, Texas Gulf Coast Plain, 2000-2002

    National Research Council Canada - National Science Library

    East, Jeffery W; Hogan, Jennifer L

    2003-01-01

    During July 2000 September 2002, the U.S. Geological Survey collected and analyzed site-specific hydrologic, water-quality, and biological data in Dickinson Bayou, Armand Bayou, and the San Bernard River in the Gulf Coastal Plain of Texas...

  6. Retrograde study of CART- or NPY-neuronal projection from the hypothalamic arcuate nucleus to the dorsal raphe and/or the locus coeruleus in the rat.

    Science.gov (United States)

    Yoon, Ye S; Lee, Ji S; Lee, Hyun S

    2013-06-26

    The present study was designed to reveal cocaine- and amphetamine-regulated transcript (CART)- or neuropeptide Y (NPY)-immunoreactive neuronal projections from the hypothalamic arcuate nucleus (Arc) to the dorsal raphe (DR) and/or the locus coeruleus (LC) in the rat. Our results demonstrated that CART or NPY axon terminals formed close appositions to the neuronal profiles in the DR and the LC. Thus, arcuate sections were immunostained for the CART or NPY after the injections of green RetroBeads(™) into the DR and red tracer into the LC (or vice versa). First, retrogradely-labeled CART cells were mainly observed in the lateral Arc without colchicine. Of the total population of arcuate CART neurons, DR- and LC-projecting cells were 5.7% ± 0.9% and 6.6% ± 0.7%, respectively. In addition, a subset (3.3% ± 0.7%) of CART neurons provided divergent axon collaterals to the DR and the LC. Second, retrogradely-labeled NPY cells were observed in lateral or ventral borders of the medial Arc only after colchicine injection. Of the entire NPY cell population, DR- and LC-projecting neurons were 1.5% ± 0.3% and 1.3% ± 0.3%, respectively. Only a scanty proportion (0.1% ± 0.0%) sent axon collaterals to the DR and the LC. These observations suggested that arcuate CART or NPY system might have a potential influence on the brainstem monoaminergic nuclei, modulating their roles in feeding, nociception, emotional behaviors, arousal, and stress responses. Furthermore, a portion of arcuate CART neurons (along with only a few NPY cells) sending divergent axon collaterals to the DR/LC might have a simultaneous (and possibly more efficient) way to exert their specific influences on the monoaminergic nuclei.

  7. Dual projections of single orexin- or CART-immunoreactive, lateral hypothalamic neurons to the paraventricular thalamic nucleus and nucleus accumbens shell in the rat: Light microscopic study.

    Science.gov (United States)

    Lee, Eun Y; Lee, Hyun S

    2016-03-01

    The paraventricular thalamic nucleus (PVT) is a major relay station to the limbic forebrain areas such as the nucleus accumbens shell (AcbSh). Both PVT and AcbSh are known to receive feeding/arousal-related peptidergic fibers including orexin (ORX) and cocaine- and amphetamine-regulated transcript (CART) peptide. In the first series of experiments, we examined the peptidergic fiber distribution in the AcbSh; the density of ORX (or CART) fibers in the AcbSh was substantially lower than that in the PVT. At the light microscopic level, ORX (or CART) terminals formed close appositions to choline acetyltransferase (ChAT)-, glutamate decarboxylase (GAD)-, or enkephalin (Enk)-immunoreactive neuronal elements in the AcbSh. In the second series of experiments, we addressed the question of whether single ORX (or CART) cells in the hypothalamus provided divergent axon collaterals to the PVT and AcbSh. ORX neurons with dual projections were found in the medial, central, and lateral subdivisions of the lateral hypothalamus (LH), which amounted to an average of 1.6% of total ORX cells. CART neurons with divergent axon collaterals were observed in the LH, zona incerta, dorsal hypothalamic area, and retrochiasmatic nucleus, which represented a mean of 2.5% of total CART cells. None of arcuate CART cells sent dual projections. These data suggested that a portion of ORX (or CART) neurons in the hypothalamus, via divergent axon collaterals, might concurrently modulate the activity of PVT and AcbSh cells to affect feeding and drug-seeking behaviors.

  8. Fungal infection as a risk factor for HIV disease progression among patients with a CD4 count above 200/microl in the era of cART

    DEFF Research Database (Denmark)

    Podlekareva, Daria; Mocroft, Amanda; Kirk, Ole;

    2008-01-01

    using Poisson regression. After adjustment for current CD4 cell count, HIV-RNA, starting cART and diagnosis of AAS-AIDS, AMT was significantly associated with an increased incidence of non-AAS-AIDS (IRR=1.55, 95% CI 1.17-2.06, p=0.0024). Despite low incidence of AIDS in the cART era, FI in patients...

  9. Improved antiretroviral treatment outcome in a rural African setting is associated with cART initiation at higher CD4 cell counts and better general health condition

    Directory of Open Access Journals (Sweden)

    Geubbels Eveline

    2011-04-01

    Full Text Available Abstract Background Data on combination antiretroviral therapy (cART in remote rural African regions is increasing. Methods We assessed prospectively initial cART in HIV-infected adults treated from 2005 to 2008 at St. Francis Designated District Hospital, Ifakara, Tanzania. Adherence was assisted by personal adherence supporters. We estimated risk factors of death or loss to follow-up by Cox regression during the first 12 months of cART. Results Overall, 1,463 individuals initiated cART, which was nevirapine-based in 84.6%. The median age was 40 years (IQR 34-47, 35.4% were males, 7.6% had proven tuberculosis. Median CD4 cell count was 131 cells/μl and 24.8% had WHO stage 4. Median CD4 cell count increased by 61 and 130 cells/μl after 6 and 12 months, respectively. 215 (14.7% patients modified their treatment, mostly due to toxicity (56%, in particular polyneuropathy and anemia. Overall, 129 patients died (8.8% and 189 (12.9% were lost to follow-up. In a multivariate analysis, low CD4 cells at starting cART were associated with poorer survival and loss to follow-up (HR 1.77, 95% CI 1.15-2.75, p = 0.009; for CD4 100 cells/μl. Higher weight was strongly associated with better survival (HR 0.63, 95% CI 0.51-0.76, p Conclusions cART initiation at higher CD4 cell counts and better general health condition reduces HIV related mortality in a rural African setting. Efforts must be made to promote earlier HIV diagnosis to start cART timely. More research is needed to evaluate effective strategies to follow cART at a peripheral level with limited technical possibilities.

  10. Veulent-ils encore une carte de presse ? Les jeunes journalistes de Belgique francophone

    Directory of Open Access Journals (Sweden)

    Olivier Standaert

    2013-12-01

    Full Text Available Cet article questionne les formes identitaires développées par les jeunes journalistesbelges lorsque se pose à eux la question de la possession de la carte de presse. La méthodologie s’appuie sur une étude descriptive du profil professionnel des jeunes journalistes et sur des entretiens non directifs menés auprès de journalistes, encartés ou non, ayant moins de cinq ans d’ancienneté. Il apparaît qu’une part importante d’entre eux ne répond plus, et ce durant une période de plus en plus longue, aux critères stricts d’obtention de la carte de presse tels que définis par les autorités belges. La carte de presse est par conséquent souvent sollicitée après l’insertion effective sur le marché du travail. Ceci peut s’expliquer par la précarisation des conditions d’insertion dans le groupe professionnel des journalistes. La montée de la précarisation au sein des médias d’information générale est une des hypothèses explicatives du décalage fréquemment constaté entre les formes identitaires traditionnelles, attachées à la carte de presse, et celles des jeunes journalistes, dominées par la figure de l’individu précaire, flexible et substituable en dépit d’une vocation affichée. Les entretiens mettent cependant en évidence un discours ambivalent où une rhétorique d’indifférence, de questionnement, voire de rejet par rapport à tout document se donnant un pouvoir d’authentifier qui est journaliste et qui ne l’est pas, côtoie un discours de conciliation et d’adhésion, mettant en avant la force symbolique de cette carte et la forme d’aboutissement identitaire que sa délivrance continue d’incarner. Il est significatif de noter que les instances d’agréation adaptent leurs pratiques, plus que leurs discours, à ces nouvelles situations professionnelles et aux identités qui en découlent : la délivrance de la carte de presse se fait de plus en plus au cas par cas, et avec une certaine

  11. Les cartes d'amor a la novel·la grega antiga i al Curial e Güelfa

    OpenAIRE

    Pomer Monferrer, Juan José

    2014-01-01

    La inclusió de cartes d'amor al Curial e Güelfa, així com a la novel·la cavalleresca catalana, és un element literari la funció del qual no només es limita a la comunicació entre els enamorats, sinó que també és capaç de dinamitzar la trama, provocar reaccions dramàtiques i configurar la psicologia dels personatges. Les cartes d'amor a la novel·la sorgeixen juntament amb el mateix gènere, l'últim de la Grècia antiga, i el Curial, consegüentment, també en presenta, directament influenciat per ...

  12. Anti-Swing and Position Control of Double Inverted Pendulum (DIP on Cart Using Hybrid Neuro-Fuzzy Controllers

    Directory of Open Access Journals (Sweden)

    Ashwani Kharola

    2016-07-01

    Full Text Available This paper illustrates a comparison study for control of highly non-linear Double Inverted Pendulum (DIP on cart. A Matlab-Simulink model of DIP has been built using Newton's second law. The Neuro-fuzzy controllers stabilizes pendulums at vertical position while cart moves in horizontal direction. This study proposes two soft-computing techniques namely Fuzzy logic reasoning and Neural networks (NN's for control of DIP systems. The results shows that Fuzzy controllers provides better results as compared to NN's controllers in terms of settling time (sec, maximum overshoot (degree and steady state error. The regression (R and mean square error (MSE values obtained after training of Neural network were satisfactory. The simulation results proves the validity of proposed techniques.

  13. Circulating serovars of Leptospira in cart horses of central and southern Ethiopia and associated risk factors.

    Science.gov (United States)

    Tsegay, K; Potts, A D; Aklilu, N; Lötter, C; Gummow, B

    2016-03-01

    Little work has been done on diseases of horses in Ethiopia or tropical regions of the world. Yet, Ethiopia has the largest horse population in Africa and their horses play a pivotal role in their economy as traction animals. A serological and questionnaire survey was therefore conducted to determine the circulating serovars of Leptospira and their association with potential risk factors in the cart horse population of Central and Southern Ethiopia. A total of 184 out of 418 cart horses from 13 districts had antibody titres of 1:100 or greater to at least one of 16 serovars of Leptospira species in Central and Southern Ethiopian horses. A significantly higher seropositivity (62.1%) was noted in horses from the highland agroecology followed by midland (44.4%) and lowland (39.8%). Serovar Bratislava (34.5%) was the predominant serovar followed by serovars Djasiman (9.8%), Topaz (5.98%) and Pomona (5.3%). Age and location proved to be associated with seropositive horses with older horses being more commonly affected and the districts of Ziway (Batu) (Apparent Prevalence (AP)=65.5%), Shashemene (AP=48.3%) and Sebeta (AP=41.4%) having the highest prevalence. Multivariable logistic regression found risk factors significantly associated with Leptospira seropositive horses were drinking river water (OR=2.8) and horses 7-12 years old (OR=5) and risk factors specifically associated with serovar Bratislava seropositive horses were drinking river water (OR=2.5), horses ≥13 years (OR=3.5) and the presence of dogs in adjacent neighbouring properties (OR=0.3). Dogs had a protective effect against seropositivity to serovars Bratislava and Djasiman, which may be due to their ability to control rodents. The high seroprevalence confirm that leptospirosis is endemic among horses of Central and Southern Ethiopia. The predominance of serovar Bratislava supports the idea that serovar Bratislava may be adapted to and maintained by the horse population of Central and Southern Ethiopia

  14. 新型Cart Pushback“后进先出”高效仓储系统

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    InterroII公司的工程师重新设计了采用”后进先出”(LIFO)模式的Cart Pushback托盘/容器仓储系统。托盘在滑道中依次压入存放,最后入库的托盘靠近通道,最先取货。

  15. Feature-based decision rules for control charts pattern recognition: A comparison between CART and QUEST algorithm

    Directory of Open Access Journals (Sweden)

    Shankar Chakraborty

    2012-01-01

    Full Text Available Control chart pattern (CCP recognition can act as a problem identification tool in any manufacturing organization. Feature-based rules in the form of decision trees have become quite popular in recent years for CCP recognition. This is because the practitioners can clearly understand how a particular pattern has been identified by the use of relevant shape features. Moreover, since the extracted features represent the main characteristics of the original data in a condensed form, it can also facilitate efficient pattern recognition. The reported feature-based decision trees can recognize eight types of CCPs using extracted values of seven shape features. In this paper, a different set of seven most useful features is presented that can recognize nine main CCPs, including mixture pattern. Based on these features, decision trees are developed using CART (classification and regression tree and QUEST (quick unbiased efficient statistical tree algorithms. The relative performance of the CART and QUEST-based decision trees are extensively studied using simulated pattern data. The results show that the CART-based decision trees result in better recognition performance but lesser consistency, whereas, the QUEST-based decision trees give better consistency but lesser recognition performance.

  16. Using and comparing two nonparametric methods (CART and RF and SPOT-HRG satellite data to predictive tree diversity distribution

    Directory of Open Access Journals (Sweden)

    SIAVASH KALBI

    2014-05-01

    Full Text Available Kalbi S, Fallah A, Hojjati SM. 2014. Using and comparing two nonparametric methods (CART and RF and SPOT-HRG satellite data to predictive tree diversity distribution. Nusantara Bioscience 6: 57-62. The prediction of spatial distributions of tree species by means of survey data has recently been used for conservation planning. Numerous methods have been developed for building species habitat suitability models. The present study was carried out to find the possible proper relationships between tree species diversity indices and SPOT-HRG reflectance values in Hyrcanian forests, North of Iran. Two different modeling techniques, Classification and Regression Trees (CART and Random Forest (RF, were fitted to the data in order to find the most successfully model. Simpson, Shannon diversity and the reciprocal of Simpson indices were used for estimating tree diversity. After collecting terrestrial information on trees in the 100 samples, the tree diversity indices were calculated in each plot. RF with determinate coefficient and RMSE from 56.3 to 63.9 and RMSE from 0.15 to 0.84 has better results than CART algorithms with determinate coefficient 42.3 to 63.3 and RMSE from 0.188 to 0.88. Overall the results showed that the SPOT-HRG satellite data and nonparametric regression could be useful for estimating tree diversity in Hyrcanian forests, North of Iran.

  17. Classication of Status of the Region on Java Island using C4.5, CHAID, and CART Methods

    Science.gov (United States)

    Syaraswati, R. A.; Slamet, I.; Winarno, B.

    2017-06-01

    The indicator of region economic success can be measured by economic growth, presented by value of Gross Regional Domestic Product (GRDP). Java island has the biggest GDP contribution toward the Indonesian government, but not all of the region gives equality contribution. The C4.5, CHAID, and CART methods can be used for classifying the status of the region with nonparametric approach. The C4.5 and CHAID methods are non-binary decision tree, meanwhile the CART methods is binary decision tree. The purposes of this paper are to know how the classification and to determine the factors that influence on classification of the region. The dependent variable is status of the region which is divided into four categories based on Klassen typology. The result shows factors that have the biggest contribution on classification of status of the region on Java island based on C4.5 method are economic growth rate, electricity, gas, and water sector, and area. The factors that have the biggest contribution based on CHAID method are growth rate, manufacturing sector, and electricity, gas, and water sector, while based on CART method are growth rate, manufacturing sector, and electricity, gas, and water sector.

  18. Kinesin-5/Eg5 is important for transport of CARTS from the trans-Golgi network to the cell surface

    Science.gov (United States)

    Villeneuve, Julien; van Galen, Josse; Cruz-Garcia, David; Tagaya, Mitsuo

    2013-01-01

    Here we report that the kinesin-5 motor Klp61F, which is known for its role in bipolar spindle formation in mitosis, is required for protein transport from the Golgi complex to the cell surface in Drosophila S2 cells. Disrupting the function of its mammalian orthologue, Eg5, in HeLa cells inhibited secretion of a protein called pancreatic adenocarcinoma up-regulated factor (PAUF) but, surprisingly, not the trafficking of vesicular stomatitis virus G protein (VSV-G) to the cell surface. We have previously reported that PAUF is transported from the trans-Golgi network (TGN) to the cell surface in specific carriers called CARTS that exclude VSV-G. Inhibition of Eg5 function did not affect the biogenesis of CARTS; however, their migration was delayed and they accumulated near the Golgi complex. Altogether, our findings reveal a surprising new role of Eg5 in nonmitotic cells in the facilitation of the transport of specific carriers, CARTS, from the TGN to the cell surface. PMID:23857769

  19. Coinjection of CCK and leptin reduces food intake via increased CART/TRH and reduced AMPK phosphorylation in the hypothalamus.

    Science.gov (United States)

    Akieda-Asai, Sayaka; Poleni, Paul-Emile; Date, Yukari

    2014-06-01

    CCK and leptin are anorectic hormones produced in the small intestine and white adipose tissue, respectively. Investigating how these hormones act together as an integrated anorectic signal is important for elucidating the mechanisms by which energy balance is maintained. We found here that coadministration of subthreshold CCK and leptin, which individually have no effect on feeding, dramatically reduced food intake in rats. Phosphorylation of AMP-activated protein kinase (AMPK) in the hypothalamus significantly decreased after coinjection of CCK and leptin. In addition, coadministration of these hormones significantly increased mRNA levels of anorectic cocaine- and amphetamine-regulated transcript (CART) and thyrotropin-releasing hormone (TRH) in the hypothalamus. The interactive effect of CCK and leptin on food intake was abolished by intracerebroventricular preadministration of the AMPK activator AICAR or anti-CART/anti-TRH antibodies. These findings indicate that coinjection of CCK and leptin reduces food intake via reduced AMPK phosphorylation and increased CART/TRH in the hypothalamus. Furthermore, by using midbrain-transected rats, we investigated the role of the neural pathway from the hindbrain to the hypothalamus in the interaction of CCK and leptin to reduce food intake. Food intake reduction induced by coinjection of CCK and leptin was blocked in midbrain-transected rats. Therefore, the neural pathway from hindbrain to hypothalamus plays an important role in transmitting the anorectic signals provided by coinjection of CCK and leptin. Our findings give further insight into the mechanisms of feeding and energy balance. Copyright © 2014 the American Physiological Society.

  20. A Car Transportation System in Cooperation by Multiple Mobile Robots for Each Wheel: iCART II

    Science.gov (United States)

    Kashiwazaki, Koshi; Yonezawa, Naoaki; Kosuge, Kazuhiro; Sugahara, Yusuke; Hirata, Yasuhisa; Endo, Mitsuru; Kanbayashi, Takashi; Shinozuka, Hiroyuki; Suzuki, Koki; Ono, Yuki

    The authors proposed a car transportation system, iCART (intelligent Cooperative Autonomous Robot Transporters), for automation of mechanical parking systems by two mobile robots. However, it was difficult to downsize the mobile robot because the length of it requires at least the wheelbase of a car. This paper proposes a new car transportation system, iCART II (iCART - type II), based on “a-robot-for-a-wheel” concept. A prototype system, MRWheel (a Mobile Robot for a Wheel), is designed and downsized less than half the conventional robot. First, a method for lifting up a wheel by MRWheel is described. In general, it is very difficult for mobile robots such as MRWheel to move to desired positions without motion errors caused by slipping, etc. Therefore, we propose a follower's motion error estimation algorithm based on the internal force applied to each follower by extending a conventional leader-follower type decentralized control algorithm for cooperative object transportation. The proposed algorithm enables followers to estimate their motion errors and enables the robots to transport a car to a desired position. In addition, we analyze and prove the stability and convergence of the resultant system with the proposed algorithm. In order to extract only the internal force from the force applied to each robot, we also propose a model-based external force compensation method. Finally, proposed methods are applied to the car transportation system, the experimental results confirm their validity.

  1. The CARTS study: Chemoradiation therapy for rectal cancer in the distal rectum followed by organ-sparing transanal endoscopic microsurgery

    Directory of Open Access Journals (Sweden)

    Bökkerink Guus MJ

    2011-12-01

    Full Text Available Abstract Background The CARTS study is a multicenter feasibility study, investigating the role of rectum saving surgery for distal rectal cancer. Methods/Design Patients with a clinical T1-3 N0 M0 rectal adenocarcinoma below 10 cm from the anal verge will receive neoadjuvant chemoradiation therapy (25 fractions of 2 Gy with concurrent capecitabine. Transanal Endoscopic Microsurgery (TEM will be performed 8 - 10 weeks after the end of the preoperative treatment depending on the clinical response. Primary objective is to determine the number of patients with a (near complete pathological response after chemoradiation therapy and TEM. Secondary objectives are the local recurrence rate and quality of life after this combined therapeutic modality. A three-step analysis will be performed after 20, 33 and 55 patients to ensure the feasibility of this treatment protocol. Discussion The CARTS-study is one of the first prospective multicentre trials to investigate the role of a rectum saving treatment modality using chemoradiation therapy and local excision. The CARTS study is registered at clinicaltrials.gov (NCT01273051

  2. Factors Affecting Nitrate Delivery to Streams from Shallow Ground Water in the North Carolina Coastal Plain

    Science.gov (United States)

    Harden, Stephen L.; Spruill, Timothy B.

    2008-01-01

    An analysis of data collected at five flow-path study sites between 1997 and 2006 was performed to identify the factors needed to formulate a comprehensive program, with a focus on nitrogen, for protecting ground water and surface water in the North Carolina Coastal Plain. Water-quality protection in the Coastal Plain requires the identification of factors that affect the transport of nutrients from recharge areas to streams through the shallow ground-water system. Some basins process or retain nitrogen more readily than others, and the factors that affect nitrogen processing and retention were the focus of this investigation to improve nutrient management in Coastal Plain streams and to reduce nutrient loads to coastal waters. Nitrate reduction in ground water was observed at all five flow-path study sites in the North Carolina Coastal Plain, although the extent of reduction at each site was influenced by various environmental, hydrogeologic, and geochemical factors. Denitrification was the most common factor responsible for decreases in nitrate along the ground-water flow paths. Specific factors, some of which affect denitrification rates, that appeared to influence ground-water nitrate concentrations along the flow paths or in the streams include soil drainage, presence or absence of riparian buffers, evapotranspiration, fertilizer use, ground-water recharge rates and residence times, aquifer properties, subsurface tile drainage, sources and amounts of organic matter, and hyporheic processes. The study data indicate that the nitrate-reducing capacity of the buffer zone combined with that of the hyporheic zone can substantially lower the amount of ground-water nitrate discharged to streams in agricultural settings of the North Carolina Coastal Plain. At the watershed scale, the effects of ground-water discharge on surface-water quality appear to be greatly influenced by streamflow conditions and the presence of extensive riparian vegetation. Streamflow statistics

  3. Comparison of most adaptive meta model With newly created Quality Meta-Model using CART Algorithm

    Directory of Open Access Journals (Sweden)

    Jasbir Malik

    2012-09-01

    Full Text Available To ensure that the software developed is of high quality, it is now widely accepted that various artifacts generated during the development process should be rigorously evaluated using domain-specific quality model. However, a domain-specific quality model should be derived from a generic quality model which is time-proven, well-validated and widely-accepted. This thesis lays down a clear definition of quality meta-model and then identifies various quality meta-models existing in the research and practice-domains. This thesis then compares the various existing quality meta-models to identify which model is the most adaptable to various domains. A set of criteria is used to compare the various quality meta-models. In this we specify the categories, as the CART Algorithms is completely a tree architecture which works on either true or false meta model decision making power .So in the process it has been compared that , if the following items has been found in one category then it falls under true section else under false section .

  4. Development of a cart for independent mobility assistance for non-ambulatory children.

    Science.gov (United States)

    Kakimoto, Akira; Suzuki, Shigenobu; Sekiguchi, Yukio

    2009-01-01

    Some parents of non-ambulatory children are not eager to allow their children to use powered wheelchairs because of apprehension of further deterioration of their functionality and the risk for accidents. The authors think that not all but some such children could develop their ability to operate powered wheelchairs and might expand their knowledge about the circumstances and interests in them. Thus we made a prototype cart for them eventually to experience motion by themselves. Based on a 6-wheeled chassis, the two middle wheels are driven with a traction roller drive system. We had been testing this prototype with a child with cerebral palsy for one year. Acquisition of skills in pushing switches and enjoyment of motion were confirmed. However, we encountered several problems such as difficulty in rolling on a carpet and in handling due to its weight. The ability to record moving speed and operation of input devices helps rehabilitation experts to conduct quantitative performance evaluation. To solve these problems, we manufactured another prototype. The second prototype was tested with another child with cerebral palsy for one year. The problems were solved. She acquired the operation skills necessary to operate the prototype with four switch operation.

  5. CDC-SF: PROPER MOTION CATALOGUE FROM CARTE DU CIEL PLATES, SAN FERNANDO ZONE

    Directory of Open Access Journals (Sweden)

    B. Vicente

    2008-01-01

    Full Text Available Presentamos un catálogo astrométrico de posiciones y movimientos propios, obtenido con las placas Carte du Ciel de la zona de San Fernando, material fotográfico de época media 1901.4 y magnitud Limite V~15. Se ha utilizado un escáner comercial de sobremesa para la digitalización de las placas. Ha sido necesario desarrollar técnicas especiales para el tratamiento del material y corregir la amplia distorsión que introduce el escáner. Las coordenadas ecuatoriales están en el sistema ICRS mediante Tycho-2 que se usa como referencia. Los errores externos comparados con Tycho-2 son de 0:002. Para obtener movimientos propios se ha usado el catálogo UCAC2 como segunda época, obteniendo una incertidumbre de 1.2 mas/año, para las estrellas de V<_14. Como muestra de la calidad del catálogo desarrollado, se presenta un análisis cinemático de siete cúmulos estelares abiertos ASCC 30, BOCHUM 3, NGC 2215, NGC 2301, NGC 2311, NGC 2323 y NGC 2548, determinando las probabilidades de pertenencia de cada estrella y las propiedades fundamentales de cada cúmulo.

  6. THORACIC DISC HERNIATION: SURGICAL DECOMPRESSION BY POSTERIOR APPROACH A LA CARTE

    Directory of Open Access Journals (Sweden)

    MURILO TAVARES DAHER

    Full Text Available ABSTRACT Objectives: To present the clinical and radiographic results of patients with thoracic disc herniation treated by the posterior approach, according to location and type of hernia (à la carte. Methods: We evaluated thirteen patients (14 hernias treated by the posterior approach. Eight (61.5% patients were male and the mean age was 53 years (34-81. Clinical evaluation was performed by the Frankel and JOA modified scales. All the patients underwent the posterior approach, which was performed by facetectomy, transpedicular approach, transpedicular + partial body resection, costotransversectomy or costotransversectomy + reconstruction with CAGE. Results: The mean follow-up was 2 years and 6 months (11-77 months. Of the 14 operated hernias, six (43% were lateral, 2 (14% paramedian, and 6 (43% central. Seven were soft (50% and seven were calcified. The transfacet approach was carried out in 5 cases (36%, transpedicular in 1 case (7%, transpedicular + partial body resection in 4 (29%, costotransversectomy in 3 (21%, and costotransversectomy + CAGE in one case (7%. The majority of patients with lateral hernia (5/6 were subjected to transfacet decompression and in cases of central and paramedian hernias, all patients underwent decompression, which is more extensive. Conclusions: The posterior approach is safe and effective, and the best approach must be chosen based on location and type of the herniation and the surgeon's experience.

  7. [New molecular classification of colorectal cancer, pancreatic cancer and stomach cancer: Towards "à la carte" treatment?].

    Science.gov (United States)

    Dreyer, Chantal; Afchain, Pauline; Trouilloud, Isabelle; André, Thierry

    2016-01-01

    This review reports 3 of recently published molecular classifications of the 3 main gastro-intestinal cancers: gastric, pancreatic and colorectal adenocarcinoma. In colorectal adenocarcinoma, 6 independent classifications were combined to finally hold 4 molecular sub-groups, Consensus Molecular Subtypes (CMS 1-4), linked to various clinical, molecular and survival data. CMS1 (14% MSI with immune activation); CMS2 (37%: canonical with epithelial differentiation and activation of the WNT/MYC pathway); CMS3 (13% metabolic with epithelial differentiation and RAS mutation); CMS4 (23%: mesenchymal with activation of TGFβ pathway and angiogenesis with stromal invasion). In gastric adenocarcinoma, 4 groups were established: subtype "EBV" (9%, high frequency of PIK3CA mutations, hypermetylation and amplification of JAK2, PD-L1 and PD-L2), subtype "MSI" (22%, high rate of mutation), subtype "genomically stable tumor" (20%, diffuse histology type and mutations of RAS and genes encoding integrins and adhesion proteins including CDH1) and subtype "tumors with chromosomal instability" (50%, intestinal type, aneuploidy and receptor tyrosine kinase amplification). In pancreatic adenocarcinomas, a classification in four sub-groups has been proposed, stable subtype (20%, aneuploidy), locally rearranged subtype (30%, focal event on one or two chromosoms), scattered subtype (36%,200 structural variation events, defects in DNA maintenance). Although currently away from the care of patients, these classifications open the way to "à la carte" treatment depending on molecular biology.

  8. FY16 Safeguards Technology Cart-Portable Mass Spectrometer Project Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, Cyril V. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Whitten, William B. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-02-01

    The Oak Ridge National Laboratory project for the Next Generation Safeguards Initiative Safeguards Technology Development Subprogram has been involved in the development of a cart portable mass spectrometer based on a Thermo ITQ ion trap mass spectrometer (referred to simply as the ITQ) for the field analysis of 235U/238U ratios in UF6. A recent discovery of the project was that combining CO2 with UF6 and introducing the mixture to the mass spectrometer (MS) appeared to increase the ionization efficiency and, thus, reduce the amount of UF6 needed for an analysis while also reducing the corrosive effects of the sample. However, initial experimentation indicated that mixing parameters should be closely controlled to ensure reproducible results. To this end, a sample manifold (SM) that would ensure the precise mixing of UF6 and CO2 was designed and constructed. A number of experiments were outlined and conducted to determine optimum MS and SM conditions which would provide the most stable isotope ratio analysis. The principal objective of the project was to provide a retrofit ITQ mass spectrometer operating with a SM capable of achieving a variation in precision of less than 1% over 1 hour of sampling. This goal was achieved by project end with a variation in precision of 0.5 to 0.8% over 1 hour of sampling.

  9. Delay In The Issuing Of D-Type Swiss Cartes De Legitimation

    CERN Multimedia

    DSU Department

    2007-01-01

    The Permanent Mission of Switzerland to the International Organisations in Geneva has informed CERN that, for technical reasons, the Federal Department of Foreign Affairs (Département fédéral des Affaires étrangères - DFAE) will be unable to issue D-type cartes de légitimation until after 15 December 2007. This is because, following the introduction of a new graphic design decided by the Swiss Federal Council, stocks of this type of card have run out. In the meantime, the Mission will issue E-type cards to the individuals concerned. These are valid for six months and will be gradually exchanged for D-type cards between December 2007 and February 2008. The Mission points out that the holding of an E-type card for a limited period will have no impact on the status of the officials in question, who will continue to benefit from immunity from jurisdiction in the discharge of their duties and be exempt from the payment of the annual tax on vehicles (a special note to this effect will be sent to the relevant...

  10. Delay in the issuing of D-type Swiss cartes de légitimation

    CERN Multimedia

    DSU Department

    2007-01-01

    The Permanent Mission of Switzerland to the International Organisations in Geneva has informed CERN that, for technical reasons, the Federal Department of Foreign Affairs (Département fédéral des Affaires étrangères - DFAE) will be unable to issue D-type cartes de légitimation until after 15 December 2007. This is because, following the introduction of a new graphic design decided by the Swiss Federal Council, stocks of this type of card have run out. In the meantime, the Mission will issue E-type cards to the individuals concerned. These are valid for six months and will be gradually exchanged for D-type cards between December 2007 and February 2008. The Mission points out that the holding of an E-type card for a limited period will have no impact on the status of the officials in question, who will continue to benefit from immunity from jurisdiction in the discharge of their duties and be exempt from the payment of the annual tax on vehicles (a special note to this e...

  11. Geology of the Gusev cratered plains from the Spirit rover transverse

    Science.gov (United States)

    Golombek, M. P.; Crumpler, L. S.; Grant, J. A.; Greeley, R.; Cabrol, N. A.; Parker, T. J.; Rice, J. W.; Ward, J. G.; Arvidson, R. E.; Moersch, J. E.; Fergason, R. L.; Christensen, P. R.; Castaño, A.; Castaño, R.; Haldemann, A. F. C.; Li, R.; Bell, J. F.; Squyres, S. W.

    2006-01-01

    The cratered plains of Gusev traversed by Spirit are generally low-relief rocky plains dominated by impact and eolian processes. Ubiquitous shallow, soil-filled, circular depressions, called hollows, are modified impact craters. Rocks are dark, fine-grained basalts, and the upper 10 m of the cratered plains appears to be an impact-generated regolith developed over intact basalt flows. Systematic field observations across the cratered plains identified vesicular clasts and rare scoria similar to original lava flow tops, consistent with an upper inflated surface of lava flows with adjacent collapse depressions. Crater and hollow morphometry are consistent with most being secondaries. The size-frequency distribution of rocks >0.1 m diameter generally follows exponential functions similar to other landing sites for total rock abundances of 5-35%. Systematic clast counts show that areas with higher rock abundance and more large rocks have higher thermal inertia. Plains with lower thermal inertia have fewer rocks and substantially more pebbles that are well sorted and evenly spaced, similar to a desert pavement or lag. Eolian bed forms (ripples and wind tails) have coarse surface lags, and many are dust covered and thus likely inactive. Deflation of the surface ~5-25 cm likely exposed two-toned rocks and elevated ventifacts and transported fines into craters creating the hollows. This observed redistribution yields extremely slow average erosion rates of ~0.03 nm/yr and argues for very little long-term net change of the surface and a dry and desiccating environment similar to today's since the Hesperian (or ~3 Ga).

  12. Geology of the Gusec cratered plains from the Spirit rover transverse

    Science.gov (United States)

    Golombek, M. P.; Crumpler, L. S.; Grant, J. A.; Greely, R.; Cabrol, N. A.; Parker, T. J.; Rice, J. W., Jr.; Ward, J. G.; Arvidson, R. E.; Moersch, J. E.; Fergason, J. F.; Christensen, P. R.; Castano, A.; Castano, R.; Haldemann, A. F. C.; Li, R.; Bell, J. F., III; Squyres, S. W.

    2006-01-01

    The cratered plains of Gusev traversed by Spirit are generally low-relief rocky plains dominated by impact and eolian processes. Ubiquitous shallow, soil-filled, circular depressions, called hollows, are modified impact craters. Rocks are dark, fine-grained basalts, and the upper 10 m of the cratered plains appears to be an impact-generated regolith developed over intact basalt flows. Systematic field observations across the cratered plains identified vesicular clasts and rare scoria similar to original lava flow tops, consistent with an upper inflated surface of lava flows with adjacent collapse depressions. Crater and hollow morphometry are consistent with most being secondaries. The size frequency distribution of rocks >0.1 m diameter generally follows exponential functions similar to other landing sites for total rock abundances of 5-35%. Systematic clast counts show that areas with higher rock abundance and more large rocks have higher thermal inertia. Plains with lower thermal inertia have fewer rocks and substantially more pebbles that are well sorted and evenly spaced, similar to a desert pavement or lag. Eolian bed forms (ripples and wind tails) have coarse surface lags, and many are dust covered and thus likely inactive. Deflation of the surface _5-25 cm likely exposed two-toned rocks and elevated ventifacts and transported fines into craters creating the hollows. This observed redistribution yields extremely slow average erosion rates of _0.03 nm/yr and argues for very little long-term net change of the surface and a dry and desiccating environment similar to today's since the Hesperian (or _3 Ga).

  13. Fish assemblage in European Western Highlands and Western Plains: a type-specific approach to assess ecological quality of running waters

    NARCIS (Netherlands)

    Grenouillet, G.; Roset, N.; Goffaux, D.; Breine, J.; Leeuw, de J.J.

    2007-01-01

    After typological pre-classification of 398 calibration sites, fish-based metric models were used to predict the impact of human activities on river quality in European Western Highlands and Western Plains ecoregions. Calibration sites were grouped into six assemblage types and according to their ge

  14. Maraviroc Intensification of cART in Patients with Suboptimal Immunological Recovery: A 48-Week, Placebo-Controlled Randomized Trial.

    Directory of Open Access Journals (Sweden)

    Steven F L van Lelyveld

    Full Text Available The immunomodulatory effects of the CCR5-antagonist maraviroc might be beneficial in patients with a suboptimal immunological response, but results of different cART (combination antiretroviral therapy intensification studies are conflicting. Therefore, we performed a 48-week placebo-controlled trial to determine the effect of maraviroc intensification on CD4+ T-cell counts and immune activation in these patients.Double-blind, placebo-controlled, randomized trial.Major inclusion criteria were 1. CD4+ T-cell count <350 cells/μL while at least two years on cART or CD4+ T-cell count <200 cells/μL while at least one year on cART, and 2. viral suppression for at least the previous 6 months. HIV-infected patients were randomized to add maraviroc (41 patients or placebo (44 patients to their cART regimen for 48 weeks. Changes in CD4+ T-cell counts (primary endpoint and other immunological parameters were modeled using linear mixed effects models.No significant differences for the modelled increase in CD4+ T-cell count (placebo 15.3 CD4+ T cells/μL (95% confidence interval (CI [1.0, 29.5] versus maraviroc arm 22.9 CD4+ T cells/μL (95% CI [7.4, 38.5] p = 0.51 or alterations in the expression of markers for T-cell activation, proliferation and microbial translocation were found between the arms. However, maraviroc intensification did increase the percentage of CCR5 expressing CD4+ and CD8+ T-cells, and the plasma levels of the CCR5 ligand MIP-1β. In contrast, the percentage of ex-vivo apoptotic CD8+ and CD4+ T-cells decreased in the maraviroc arm.Maraviroc intensification of cART did not increase CD4+ T-cell restoration or decrease immune activation as compared to placebo. However, ex-vivo T-cell apoptosis was decreased in the maraviroc arm.ClinicalTrials.gov NCT00875368.

  15. Maraviroc Intensification of cART in Patients with Suboptimal Immunological Recovery: A 48-Week, Placebo-Controlled Randomized Trial

    Science.gov (United States)

    van Lelyveld, Steven F. L.; Otto, Sigrid A.; Richter, Clemens; Soetekouw, Robin; Prins, Jan M.; Brinkman, Kees; Mulder, Jan Willem; Kroon, Frank; Middel, Ananja; Symons, Jori; Wensing, Annemarie M. J.; Nijhuis, Monique; Borghans, José A. M.; Tesselaar, Kiki; Hoepelman, Andy I. M.

    2015-01-01

    Objective The immunomodulatory effects of the CCR5-antagonist maraviroc might be beneficial in patients with a suboptimal immunological response, but results of different cART (combination antiretroviral therapy) intensification studies are conflicting. Therefore, we performed a 48-week placebo-controlled trial to determine the effect of maraviroc intensification on CD4+ T-cell counts and immune activation in these patients. Design Double-blind, placebo-controlled, randomized trial. Methods Major inclusion criteria were 1. CD4+ T-cell count <350 cells/μL while at least two years on cART or CD4+ T-cell count <200 cells/μL while at least one year on cART, and 2. viral suppression for at least the previous 6 months. HIV-infected patients were randomized to add maraviroc (41 patients) or placebo (44 patients) to their cART regimen for 48 weeks. Changes in CD4+ T-cell counts (primary endpoint) and other immunological parameters were modeled using linear mixed effects models. Results No significant differences for the modelled increase in CD4+ T-cell count (placebo 15.3 CD4+ T cells/μL (95% confidence interval (CI) [1.0, 29.5] versus maraviroc arm 22.9 CD4+ T cells/μL (95% CI [7.4, 38.5] p = 0.51) or alterations in the expression of markers for T-cell activation, proliferation and microbial translocation were found between the arms. However, maraviroc intensification did increase the percentage of CCR5 expressing CD4+ and CD8+ T-cells, and the plasma levels of the CCR5 ligand MIP-1β. In contrast, the percentage of ex-vivo apoptotic CD8+ and CD4+ T-cells decreased in the maraviroc arm. Conclusions Maraviroc intensification of cART did not increase CD4+ T-cell restoration or decrease immune activation as compared to placebo. However, ex-vivo T-cell apoptosis was decreased in the maraviroc arm. Trial Registration ClinicalTrials.gov NCT00875368 PMID:26208341

  16. Suitable scale of Weigan River plain oasis

    Institute of Scientific and Technical Information of China (English)

    HU ShunJun; SONG YuDong; TIAN ChangYan; LI YueTan; LI XiuCang; CHEN XiaoBing

    2007-01-01

    Desert coexists with oasis in long time, and the existence and development of oasis system demand better oasis vegetation ecological system. Oasis scale of arid zone plain encircling water should be determined in case of desertification caused by land over-reclamation under the circumstance of water resources shortage. Steady oasis with virtuous circle must have appropriate land use structure for agriculture, forestry and graziery. The study on the suitable scale and developmental space of oasis will provide theoretical and applicable foundation for effective construction of oases. By analyzing the hydrothermal, water and soil balance, an optimal mathematical model has been established. Based on hydrometeorology data collected for years in Weigan River plain, and by the principle of water balance,a calculation has been made of the water resources for evapotranspiration and the optimal acreage of oasis and cultivated land, which shows that the water resources for evapotranspiration in the Weigan River plain oasis is 22.32×108 m3 and the optimal oasis acreage under the condition of conventional irrigation mode is 3716.06 km2, in which the suitable cultivated land acreage is 1564.79 km2. Under the condition of water-saving irrigation, the suitable oasis acreage is 5515.49 km2, in which the suitable cultivated land acreage is 2322.31 km2. The oasis area had reached 4123 km2, and the cultivated land acreage had reached 1507 km2 after the Agriculture Irrigation Drainage Water Project of World Bank Loan in Weigan River basin was finished in 1997. The oasis and cultivated land acreage will be more suitable, and the oasis scale can be enlarged moderately by means of water saving irrigation.

  17. Ages of plains volcanism on Mars

    Science.gov (United States)

    Hauber, Ernst; Jagert, Felix; Broz, Petr

    2010-05-01

    Plain-style volcanism [1] is widespread in the Tharsis and Elysium volcanic provinces on Mars, [2,3]. Detailed images and topographic data reveal the morphology and topography of clusters of low shields and associated lava flows. The landforms of plains volcanism on Mars have all well-known terrestrial analogues in basaltic volcanic regions, such as Hawaii, Iceland, and in particular the Snake River Plains [4]. The very gentle flank slopes (Ga - 2.9 Ga). Our results indicate that Late Amazonian volcanism is more widespread in Tharsis than previously recognized. Based on our results it appears possible that Mars is volcanologically not dead yet. Ongoing work investigates the volumes of erupted products and implications for the outgassing history and atmospheric evolution of Mars. [1] Greeley R. (1982) JGR 87, 2705-2712. [2] Plescia J. (1981) Icarus, 45, 586-601. [3] Hodges C.A. and Moore H.J. (1994) Atlas of volcanic features on Mars: USGS Prof. Paper 1534, 194 p. [4] Hauber E. et al. (2009) J. Volcanol. Geotherm. Res. 185, 69-95. [5] Wilson L. et al. (2009) J. Volcanol. Geotherm. Res. 185, 28-46. [6] Vaucher, J. et al. (2009) Icarus 204, 418-442. [7] Baratoux D. et al. (2009) J. Volcanol. Geotherm. Res. 185, 47-68. [8] Bleacher J.E. et al. (2009) J. Volcanol. Geotherm. Res. 185, 96-102. [9] Ivanov B.A. (2001) Space Sci. Rev. 96, 87-104. [10] Hartmann W.H. and Neukum G. (2001) Space Sci. Rev. 96, 165-194 [11] Kneissl T. et al. (2010) LPS XVI, submitted. [12] Michael, G.G. and Neukum G. (2010) Earth Planet. Sci. Lett., in press. . [13] Malin M.C. et al. (2007) JGR 112, E05S04, doi: 10.1029/2006JE002808.

  18. Bone and joint changes following electrical burn: plain radiographic findings

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Uk Jung; Lee, Eil Seong; Shim, Ya Seong; Kim, Seon Bok; Lee, Shin Ho; Jung, Hae Kyoung; Hwang, Dae Hyun; Kang, Ik Won [Hallym Univ. College of Medicine, Seoul (Korea, Republic of)

    1998-10-01

    To evaluate the plain radiographic findings of bone and joint changes following electrical burn. This study involved 19 patients with 27 bone and joints regions which had suffered electrical injury. The most common input and output sites were, respectively, the hand(7/14) and foot (6/10). Three other sites were involved. Four cases involved osteomyelitis, and in four, amputation was performed. We observed bone and joint changes, changes following osteomyelitis and changes in the amputation stump. We analyzed the difference between input and output changes, and when this was interesting, the average time of onset was assessed. In bone and joint changes following electrical burn, the most frequent radiographic finding was joint contracture(n=3D16). Other findings included osteolysis(n=3D8), articular abnormalites (n=3D6), periostitis(n=3D5), fracture(n=3D5), acro-osteolysis(n=3D2), and heterotopic bone formation(n=3D2). In cases involving osteomyelitis(n=3D4), aggravation of underlying bone changes was noted. In electrical burn, various changes were noted in bone and joints, and input injury was more severe than that of output.=20.

  19. Medicine Wheels of the Great Plains

    Science.gov (United States)

    Vogt, David

    Medicine Wheels are unexplained aboriginal boulder configurations found primarily on hilltops and river valley vistas across the northwest Great Plains of North America. Their varied, complex designs have inspired diverse hypotheses concerning their meaning and purpose, including astronomical ones. While initial "observatory" speculations were unfounded, and quests to "decode" these structures remain unfulfilled and possibly misguided, the Medicine Wheels nevertheless represent a uniquely worthwhile case study in archaeoastronomical theory and method. In addition, emerging technologies for data acquisition and analysis pertinent to Medicine Wheels offer prospectively important new sight lines for the future of archaeoastronomy.

  20. CART Raman Lidar Aerosol and Water Vapor Measurements in the Vicinity of Clouds

    Science.gov (United States)

    Clayton, Marian B.; Ferrare, Richard A.; Turner, David; Newsom, Rob; Sivaraman, Chitra

    2008-01-01

    Aerosol and water vapor profiles acquired by the Raman lidar instrument located at the Climate Research Facility (CRF) at Southern Great Plains (SGP) provide data necessary to investigate the atmospheric variability in the vicinity of clouds near the top of the planetary boundary layer (PBL). Recent CARL upgrades and modifications to the routine processing algorithms afforded the necessarily high temporal and vertical data resolutions for these investigations. CARL measurements are used to investigate the behavior of aerosol backscattering and extinction and their correlation with water vapor and relative humidity.