WorldWideScience

Sample records for pki workshop theory

  1. Workshop on Pion-Kaon Interactions (PKI2018) Mini-Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Amaryan, M; Pal, Bilas

    2018-02-14

    This volume is a short summary of talks given at the PKI2018 Workshop organized to discuss current status and future prospects of pi -K interactions. The precise data on pi K interaction will have a strong impact on strange meson spectroscopy and form factors that are important ingredients in the Dalitz plot analysis of a decays of heavy mesons as well as precision measurement of Vus matrix element and therefore on a test of unitarity in the first raw of the CKM matrix. The workshop has combined the efforts of experimentalists, Lattice QCD, and phenomenology communities. Experimental data relevant to the topic of the workshop were presented from the broad range of different collaborations like CLAS, GlueX, COMPASS, BaBar, BELLE, BESIII, VEPP-2000, and LHCb. One of the main goals of this workshop was to outline a need for a new high intensity and high precision secondary KL beam facility at JLab produced with the 12 GeV electron beam of CEBAF accelerator.

  2. DESY Theory Workshop

    International Nuclear Information System (INIS)

    Anon.

    1985-01-01

    Held during the 'Festwoche' which marked the 25th anniversary of the German DESY Laboratory last year, the traditional DESY Theory Workshop concentrated on weak interactions of heavy quarks and on non-standard models for weak interactions, together with a progress report on lattice gauge theories with fermions. The organizing committee had invited eleven lecturers to present experiments and theoretical ideas in these fields. Also many short communications contributed interesting material

  3. WORKSHOP: Thermal field theory

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1989-04-15

    The early history of the Universe is a crucial testing ground for theories of elementary particles. Speculative ideas about the constituents of matter and their interactions are reinforced if they are consistent with what we suppose happened near the beginning of time and discarded if they are not. The cosmological consequences of these theories are usually deduced using a general statistical approach called thermal field theory. Thus, 75 physicists from thirteen countries met in Cleveland, Ohio, last October for the first 'Workshop on Thermal Field Theories and their Applications'.

  4. DESY: Theory Workshop 1994

    International Nuclear Information System (INIS)

    Anon.

    1995-01-01

    For 1994, the traditional annual DESY Theory Workshop was devoted to supersymmetry. This is a novel symmetry relating bosons (normally force-carrying particles) and fermions (which normally feel the forces). In supersymmetry, bosons could have fermion counterparts, and vice versa. Although this subject is still largely a theorist's playground, many of the particles and phenomena predicted by models of low energy supersymmetry now seem within reach of present and planned future accelerator experiments, and this was one of the main reasons for choosing a more speculative theme after more phenomenological orientations in recent DESY Theory Workshops. After the welcome by DESY Director General Bjorn Wiik, attention was immediately focused on experimental aspects. P. Steffen (DESY) presented the latest results from HERA. In the following talks, K. Honscheid (Ohio), S. Lammel (Fermilab) and S. Komamiya (CERN and Tokyo) reviewed the experimental situation at electron-proton, hadron and electron-positron colliders, respectively. They discussed the most recent limits for supersymmetric particles (still none in sight!), as well as precision experiments where deviations from the standard model might show up. The workshop was treated to a first rate introduction to the MSSM (''minimal supersymmetric standard model'') by F. Zwirner (CERN), who clearly explained the motivation for going supersymmetric and reviewed the basic structure of the MSSM, its particle content and couplings, as well as the soft breaking terms necessary to avoid immediate conflict with experiment. This was followed by a systematic discussion of the Higgs sector by H. Haber (Santa Cruz), where the first hints of new physics could appear. However, he also made clear that it may not be easy to distinguish standard and non-standard Higgs bosons. Symmetries beyond the standard model, and in particular supersymmetric grand unification were treated in detail by G. Ross (Oxford) and S

  5. Tandem mirror theory workshop

    International Nuclear Information System (INIS)

    1981-05-01

    The workshop was divided into three sections which were constituted according to subject matter: RF Heating, MHD Equilibrium and Stability, and Transport and Microstability. An overview from Livermore's point of view was given at the beginning of each session. Each session was assigned a secretary to take notes. These notes have been used in preparing this report on the workshop. The report includes the activities, conclusions, and recommendations of the workshop

  6. Workshop III – Cosmology: Observations versus theories

    Indian Academy of Sciences (India)

    599–601. Workshop III – Cosmology: Observations versus theories. T R SESHADRI ... The gravitational lens image separation distribution function in the presence of evolving models of ... Restoration of local electroweak symmetry is achieved.

  7. PKI Scalability Issues

    OpenAIRE

    Slagell, Adam J; Bonilla, Rafael

    2004-01-01

    This report surveys different PKI technologies such as PKIX and SPKI and the issues of PKI that affect scalability. Much focus is spent on certificate revocation methodologies and status verification systems such as CRLs, Delta-CRLs, CRS, Certificate Revocation Trees, Windowed Certificate Revocation, OCSP, SCVP and DVCS.

  8. A Death Awareness Workshop: Theory, Application, and Results.

    Science.gov (United States)

    Whelan, W. Michael; Warren, William M.

    1980-01-01

    Describes an experimental death awareness workshop based on Kubler-Ross' theory. The effects of the workshop reveal cognitive and emotional changes indicating participants in the workshop to be moving towards an acceptance of death. (Author)

  9. Hvor anvendelig er PKI?

    OpenAIRE

    Nielsen, Jon Magne

    2006-01-01

    Denne oppgaven ser på bruken av elektronisk ID i statlige etater i Norge i dag. Det ses spesielt på om bruken av tekologien PKI er en god løsning på etatenes behov på dette området. Som utgangspunkt for analysen er det sett spesielt på to statlige etater. Disse etatenes behov og bruk av elektronisk ID generelt og PKI spesielt blir undersøkt. Det er videre gjort rede for hvilke lover, forskrifter og andre førende dokumenter som danner de formelle rammebetingelsene for etaters bruk av PKI. ...

  10. PUBLIC KEY INFRASTRUCTURE (PKI)

    Data.gov (United States)

    Federal Laboratory Consortium — Common Access Card (CAC)Enterprise Testing Overview:Established in 2003Performs test and evaluations of the DOD PKI CAC issuance systems from an enterprise level all...

  11. International Workshop on Operator Theory and Applications

    CERN Document Server

    Jacob, Birgit; Ran, André; Zwart, Hans

    2016-01-01

    This volume collects a selected number of papers presented at the International Workshop on Operator Theory and its Applications (IWOTA) held in July 2014 at Vrije Universiteit in Amsterdam. Main developments in the broad area of operator theory are covered, with special emphasis on applications to science and engineering. The volume also presents papers dedicated to the eightieth birthday of Damir Arov and to the sixty-fifth birthday of Leiba Rodman, both leading figures in the area of operator theory and its applications, in particular, to systems theory.

  12. Thirteen international workshop on nuclear theory. Abstracts

    International Nuclear Information System (INIS)

    1994-01-01

    This brochure contains the abstracts of reports delivered by 40 participants at the 13. International Workshop on Nuclear Theory organized by the Nuclear Theory Group in the Institute for Nuclear research and Nuclear Energy of the Bulgarian academy of Sciences. The main topics treated in the lectures were nucleon correlation effects in nuclei, collective nuclear motions, Wigner quantum systems, pre-equilibrium neutron and photon emission from nuclei, particle-nuclei collision processes at high energies, few-body states, optical potential for neutron-nucleus scattering, relativistic generator coordinate calculations and variational nuclear structure calculations. All reports are included in INIS separately

  13. Workshop on Topology and Geometric Group Theory

    CERN Document Server

    Fowler, James; Lafont, Jean-Francois; Leary, Ian

    2016-01-01

    This book presents articles at the interface of two active areas of research: classical topology and the relatively new field of geometric group theory. It includes two long survey articles, one on proofs of the Farrell–Jones conjectures, and the other on ends of spaces and groups. In 2010–2011, Ohio State University (OSU) hosted a special year in topology and geometric group theory. Over the course of the year, there were seminars, workshops, short weekend conferences, and a major conference out of which this book resulted. Four other research articles complement these surveys, making this book ideal for graduate students and established mathematicians interested in entering this area of research.

  14. Tailoring PKI for the battlespace

    Science.gov (United States)

    Covey, Carlin R.

    2003-07-01

    A Public Key Infrastructure (PKI) can provide useful communication protections for friendly forces in the battlespace. The PKI would be used in conjunction with communication facilities that are accorded physical and Type-1 cryptographic protections. The latter protections would safeguard the confidentiality and (optionally) the integrity of communications between enclaves of users, whereas the PKI protections would furnish identification, authentication, authorization and privacy services for individual users. However, Commercial-Off-the-Shelf (COTS) and most Government-Off-the-Shelf (GOTS) PKI solutions are not ideally tailored for the battlespace environment. Most PKI solutions assume a relatively static, high-bandwidth communication network, whereas communication links in the battlespace will be dynamically reconfigured and bandwidth-limited. Most enterprise-wide PKI systems assume that users will enroll and disenroll at an orderly pace, whereas the battlespace PKI "enterprise" will grow and shrink abruptly as units are deployed or withdrawn from the battlespace. COTS and GOTS PKIs are seldom required to incorporate temporary "enterprise mergers", whereas the battlespace "enterprise" will need to incorporate temporary coalitions of forces drawn from various nations. This paper addresses both well-known and novel techniques for tailoring PKI for the battlespace environment. These techniques include the design of the security architecture, the selection of appropriate options within PKI standards, and some new PKI protocols that offer significant advantages in the battlespace.

  15. Fourteen international workshop on nuclear theory

    International Nuclear Information System (INIS)

    1995-01-01

    This brochure contains the abstracts of reports delivered by 30 participants at the 14. International Workshop on Nuclear Theory organized by the Nuclear Theory Group in the Institute for Nuclear research and Nuclear Energy of the Bulgarian academy of Sciences. The main topics treated in the lectures were short-range nucleon-nucleon correlations in nuclei, relativistic scaling in nuclear matter and finite nuclei, hadron structure in chiral quark-meson theory, residual interaction strength and surface effects in the multistep reaction calculations, theoretical and experimental studies of heavy ion collisions, quantum algebraic approach to nuclear collective properties, description of low-lying states in even-even nuclei, deformed oscillator potentials, studies of solar neutrinos by I-127 detectors and gamma-ray astronomy of ultra-high energies. All reports are included in INIS separately

  16. 10th International Workshop on Condensed Matter Theories

    CERN Document Server

    Kalia, Rajiv; Bishop, R

    1987-01-01

    The second volume of Condensed Matter Theories contains the proceedings of the 10th International Workshop held at Argonne National Laboratory, Argonne, IL, U.S.A. during the week of July 21, 1986. The workshop was attended by high-energy, nuclear and condensed-matter physicists as well as materials scientists. This diverse blend of participants was in keeping with the flavor of the previous workshops. This annual series of international workshops was"started in 1977 in Sao Paulo, Brazil. Subsequent'workshops were held in Trieste (Italy), Buenos Aires (Argentina), Caracas (Venezuela), Altenberg (West Germany), Granada (Spain), and San Francisco (U.S.A.). What began as a meeting of the physicists from the Western Hemisphere has expanded in the last three years into an international conference of scientists with diverse interests and backgrounds. This diversity has promoted a healthy exchange of ideas from different branches of physics and also fruitful interactions among the participants. The present volume is...

  17. 11th International Workshop on Condensed Matter Theories

    CERN Document Server

    Bishop, R; Manninen, Matti; Condensed Matter Theories : Volume 3

    1988-01-01

    This book is the third volume in an approximately annual series which comprises the proceedings of the International Workshops on Condensed Matter Theories. The first of these meetings took place in 1977 in Sao Paulo, Brazil, and successive workshops have been held in Trieste, Italy (1978), Buenos Aires, Argentina (1979), Caracas, Venezuela (1980), Mexico City, Mexico (1981), St. Louis, USA (1982), Altenberg, Federal Republic of Germany (1983), Granada, Spain (1984), San Francisco, USA (1985), and Argonne, USA (1986). The present volume contains the proceedings of the Eleventh Workshop which took place in Qulu, Finland during the period 27 July - 1 August, 1987. The original motivation and the historical evolution of the series of Workshops have been amply described in the preface to the first volume in the present series. An important objective throughout has been to work against the ever-present trend for physics to fragment into increasingly narrow fields of specialisation, between which communication is d...

  18. CUNY Graduate Center Workshops on Combinatorial and Additive Number Theory

    CERN Document Server

    2017-01-01

    Based on talks from the 2015 and 2016 Combinatorial and Additive Number Theory (CANT) workshops at the City University of New York, these proceedings offer 19 peer-reviewed and edited papers on current topics in number theory. Held every year since 2003, the workshop series surveys state-of-the-art open problems in combinatorial and additive number theory and related parts of mathematics. Sumsets, partitions, convex polytopes and discrete geometry, Ramsey theory, primality testing, and cryptography are among the topics featured in this volume. Each contribution is dedicated to a specific topic that reflects the latest results by experts in the field. Researchers and graduate students interested in the current progress in number theory will find this selection of articles relevant and compelling. .

  19. 24th International Workshop in Operator Theory and its Applications

    CERN Document Server

    Dritschel, Michael

    2015-01-01

    This volume gathers contributions from the International Workshop on Operator Theory and Its Applications (IWOTA) held in Bangalore, India, in December 2013. All articles were written by experts and cover a broad range of original material at the cutting edge of operator theory and its applications. Topics include multivariable operator theory, operator theory on indefinite metric spaces (Krein and Pontryagin spaces) and its applications, spectral theory with applications to differential operators, the geometry of Banach spaces, scattering and time varying linear systems, and wavelets and coherent states.

  20. A Workshop for High School Students on Naive Set Theory

    Science.gov (United States)

    Wegner, Sven-Ake

    2014-01-01

    In this article we present the prototype of a workshop on naive set theory designed for high school students in or around the seventh year of primary education. Our concept is based on two events which the author organized in 2006 and 2010 for students of elementary school and high school, respectively. The article also includes a practice report…

  1. Theory and practice in the workshop

    DEFF Research Database (Denmark)

    Haastrup, Lisbeth

    2015-01-01

    of Education. Proclamation of Professional Bachelor Teacher Education Programme. Retrieved May 2014 from, https://www.retsinformation. dk/Forms/R0710.aspx?id=25302]. In this article, we reflect on the epistemological challenges we faced during a research project on the correlation between theory and practice...

  2. TERENA eScience PKI

    Science.gov (United States)

    Sova, Milan

    Several National Research and Education Networks associated in TERENA have joined their efforts to build a shared PKI able to serve potentially millions of users from their constituency. The TCS eScience Personal CA takes advantage of national identity federations to facilitate user identity vetting and enrollment procedures. The system uses identity management systems (IdMS) at participating institutions to perform the functions of registration authorities. The certificate enrollment application acts as a SAML Service Provider relying on information provided by IdMS performing as SAML Identity Providers (IdP). When applying for a personal certificate, users authenticate at their home IdP using credentials they normally use to access local services. The IdP controls the certificate issuance process by releasing SAML attributes specifying the user's eligibility for the service and the information to be included in the certificate such as the user's name and email address. The TCS eScience Personal CA is part of the TERENA Certificate Service that uses a commercial PKI provider. Outsourcing the actual CA machinery to a specialized company results in professional-level services such as CRL and OCSP management. The paper describes the legal, organizational and technical aspects of the TCS eScience PKI.

  3. International Workshop on Gauge Theories, Supersymmetry, and Mathematical Physics - Slides of the presentations

    International Nuclear Information System (INIS)

    Wit, B. de; Morier-Genoud, S.; Ovsienko, V.; Lopes Cardoso, G.; Mahapatra, S.; Sundell, P.; Boulanger, N.; Gava, E.; Karndumri, P.; Narain, K.S.; Theis, U.; Tomasiello, A.; Slizovskiy, S.; Roytenberg, D.; Voronov, T.

    2011-01-01

    This workshop was dedicated to supersymmetry, supergravity, topological field theories and their mathematical formulations. This document is composed of a large part of the slides presented at the workshop

  4. 26th International Workshop on Operator Theory and its Applications

    CERN Document Server

    Kaashoek, Marinus; Vasilevski, Nikolai; Vinnikov, Victor; IWOTA 2015; Operator theory in different settings and related applications

    2018-01-01

    This book provides a selection of reports and survey articles on the latest research in the area of single and multivariable operator theory and related fields. The latter include singular integral equations, ordinary and partial differential equations, complex analysis, numerical linear algebra, and real algebraic geometry – all of which were among the topics presented at the 26th International Workshop in Operator Theory and its Applications, held in Tbilisi, Georgia, in the summer of 2015. Moreover, the volume includes three special commemorative articles. One of them is dedicated to the memory of Leiba Rodman, another to Murray Marshall, and a third to Boris Khvedelidze, an outstanding Georgian mathematician and one of the founding fathers of the theory of singular integral equations. The book will be of interest to a broad range of mathematicians, from graduate students to researchers, whose primary interests lie in operator theory, complex analysis and applications, as well as specialists in mathemati...

  5. 76 FR 48807 - Public Key Infrastructure (PKI) Certificate Action Form

    Science.gov (United States)

    2011-08-09

    ... Infrastructure (PKI) technology to support electronic commerce between the USPTO and its customers. PKI is a set... security for its electronic commerce systems, the USPTO uses PKI technology to protect the integrity and... DEPARTMENT OF COMMERCE United States Patent and Trademark Office Public Key Infrastructure (PKI...

  6. The VIIth Blois workshop: Theory summary and factorization issues

    International Nuclear Information System (INIS)

    White, A.R.

    1997-01-01

    Theory presentations at this workshop have covered a wide range of topics. In addition to the traditional topics of elastic and diffractive scattering, the workshop has had a variety of interesting talks coming under the broad umbrella of ''Recent Advances in Hadron Physics.'' These have included review talks on lattice gauge theory, techniques for high-order perturbative QCD calculations, strong interaction effective field theories, the current status of QED and the construction of theories beyond the Standard Model. While the author briefly describes some topics covered, a ''review of reviews'' is in no way a substitute for the original reviews which also appear, of course, in this same volume. Among the more traditional topics covered are: BFKL physics -- higher-order corrections and jet cross-sections; unitarity and eikonal screening -- mainly in deep-inelastic diffraction but also in soft diffraction; elastic scattering phenomenology -- including real parts, the pomeron intercept and small-t oscillations. Also discussed is the role of factorization, i.e. both Regge pole factorization and perturbative QCD factorization theorems in the definition of a pomeron structure function and in the formulation of a parton model description of diffractive hard physics. The author focuses on one gluon versus two gluons as illustrating the issues involved

  7. Soluciones PKI basadas en Cryptlib

    OpenAIRE

    Plaza Espí, Daniel

    2008-01-01

    El objetivo de este proyecto es realizar un estudio sobre el funcionamiento y la construcción de una infraestructura de clave pública, en adelante PKI1. Para ello se llevarán a cabo dos tareas: 1. Análisis y estudio de los estándares y protocolos más actuales y avanzados que permitan el establecimiento de PKIs jerárquicas siguiendo el esquema de identidades X509v3. 2. Desarrollo software de un conjunto de herramientas que implementen los estándares estudiados y permitan la construcción de dic...

  8. 13th International Workshop on Condensed Matter Theories

    CERN Document Server

    1990-01-01

    This volume gathers the invited talks of the XIII International Work­ shop on Condensed Matter Theories which took place in Campos do Jordao near Sao Paulo, Brazil, August 6-12, 1989. It contains contributions in a wide variety of fields including neutral quantum and classical fluids, electronic systems, composite materials, plasmas, atoms, molecules and nuclei, and as this year's workshop reflected the natural preoccupation in materials science with its spectacular prospect for mankind, room tempera­ ture super-conductivity. All topics are treated from a common viewpoint: that of many-body physics, whether theoretical or simu1ational. Since the very first workshop, held at the prestigious Instituto de Fisica Teorica in Sao Paulo, and organized by the same organizer of the 1989 workshop, Professor Valdir Casaca Aguilera-Navarro, the meeting has taken place annually six times in Latin America, four in Europe and three in the United States. Its principal objective has been to innitiate and nurture collaborati...

  9. Cosmic ray diffusion: report of the workshop in cosmic ray diffusion theory

    International Nuclear Information System (INIS)

    Birmingham, T.J.; Jones, F.C.

    1975-02-01

    A workshop in cosmic ray diffusion theory was held at Goddard Space Flight Center on May 16-17, 1974. Topics discussed and summarized are: (1) cosmic ray measurements as related to diffusion theory; (2) quasi-linear theory, nonlinear theory, and computer simulation of cosmic ray pitch-angle diffusion; and (3) magnetic field fluctuation measurements as related to diffusion theory. (auth)

  10. Support of A Summer School Workshop and Workshop Focused on Theory and Applications of Time-Dependent Density Functional Theory

    Energy Technology Data Exchange (ETDEWEB)

    Maitra, Neepa [City Univ. (CUNY), NY (United States). Dept. of Physics

    2017-08-31

    The first US-based summer school and workshop on Time-Dependent Density Functional Theory (TDDFT) was held July 11-21, 2017 in Telluride, CO. This grant provided funding to enable 33 students to attend the school, specifically with lodging and registration fee reductions. TDDFT is increasingly used in computational molecular and materials science to calculate electronic-excitation spectra and dynamics in a wide variety of applications, including photocatalysis, photo-controlled bond dissociation, and light-induced charge transfer. Software development in this community targets multiple software packages, many of which are open source, such as octopus, NWchem and Qb@ll, which are the ones our school focused on. The goal of this first iteration was to create a home for a national community of scholars, including users and developers, with a deep understanding of TDDFT, its capabilities, limitations, and high-performance computing context. We used this opportunity to explore interest in such an event in the future and based on overwhelmingly positive feedback from students and teachers, we intend to hold a similar school+workshop every two years in the US, in order to maintain the high level of interest that we witnessed and the enthusiasm amongst participants.

  11. Reducing the Dependence of SPKI/SDSI on PKI

    National Research Council Canada - National Science Library

    Wang, Hao; Jha, Somesh; Reps, Thomas; Schwoon, Stefan

    2006-01-01

    .... One reason for this is that both systems require a public-key infrastructure (PKI) for authentication, and PKI has proven difficult to deploy, because each user is required to manage his/her own private/public key pair...

  12. Mobile-PKI Service Model for Ubiquitous Environment

    Science.gov (United States)

    Jeun, Inkyung; Chun, Kilsoo

    One of the most important things in PKI(Public Key Infrastructure) is the private key management issue. The private key must be deal with safely for secure PKI service. Even though PKI service is usually used for identification and authentication of user in e-commerce, PKI service has many inconvenient factors. Especially, the fact that storage media of private key for PKI service is limited to PC hard disk drive or smart card users must always carry, gives an inconvenience to user and is not suitable in ubiquitous network. This paper suggests the digital signature service using a mobile phone(m-PKI service) which is suitable in future network. A mobile phone is the most widely used for personal communication means and has a characteristic of high movability. We can use the PKI service anytime and anywhere using m-PKI.

  13. PKI security in large-scale healthcare networks

    OpenAIRE

    Mantas, G.; Lymberopoulos, D.; Komninos, N.

    2012-01-01

    During the past few years a lot of PKI (Public Key Infrastructures) infrastructures have been proposed for healthcare networks in order to ensure secure communication services and exchange of data among healthcare professionals. However, there is a plethora of challenges in these healthcare PKI infrastructures. Especially, there are a lot of challenges for PKI infrastructures deployed over large-scale healthcare networks. In this paper, we propose a PKI infrastructure to ensure security in a ...

  14. Privacy-awareness in blockchain-based PKI

    OpenAIRE

    2015-01-01

    Conventional public key infrastructure (PKI) designs are not optimal and contain security flaws; there is much work underway in improving PKI. The properties given by the Bitcoin blockchain and its derivatives are a natural solution to some of the problems with PKI - in particular, certificate transparency and elimination of single points of failure. Recently-proposed blockchain PKI designs are built as public ledgers linking identity with public key, giving no provision of privacy. We consid...

  15. Public Key Infrastructure Increment 2 (PKI Inc 2)

    Science.gov (United States)

    2016-03-01

    across the Global Information Grid (GIG) and at rest. Using authoritative data, obtained via face-to-face identity proofing, PKI creates a credential ...operating on a network by provision of assured PKI-based credentials for any device on that network. ​​​​PKI Increment One made significant...provide assured/secure validation of revocation of an electronic/ digital credential . 2.DoD PKI shall support assured revocation status requests of

  16. ICOM-ICTOP 14 October 2015 Workshop : Applying Global Theory to Local Practice

    NARCIS (Netherlands)

    Ariese, C.E.; Con, Aguilar E.O.; Martin, J.A.

    2015-01-01

    This workshop is connected to the presentation ‘Transforming global theory to local practice: Case studies from museums and education in the Caribbean’ and provides a practical and creative exercise for participants. The objective of the workshop is to support participants in exploring how to apply

  17. Theory and modeling in nanoscience: Report of the May 10-11, 2002Workshop

    Energy Technology Data Exchange (ETDEWEB)

    McCurdy, C. William; Stechel, Ellen; Cummings, Peter; Hendrickson, Bruce; Keyes, David

    2002-06-28

    On May 10 and 11, 2002, a workshop entitled ''Theory and Modeling in Nanoscience'' was held in San Francisco, California, sponsored by the offices of Basic Energy Science and Advanced Scientific Computing Research of the Department of Energy. The Basic Energy Sciences Advisory Committee and the Advanced Scientific Computing Advisory Committee convened the workshop to identify challenges and opportunities for theory, modeling, and simulation in nanoscience and nanotechnology, and additionally to investigate the growing and promising role of applied mathematics and computer science in meeting those challenges. This report is the result of those contributions and the discussions at the workshop.

  18. PKI security in large-scale healthcare networks.

    Science.gov (United States)

    Mantas, Georgios; Lymberopoulos, Dimitrios; Komninos, Nikos

    2012-06-01

    During the past few years a lot of PKI (Public Key Infrastructures) infrastructures have been proposed for healthcare networks in order to ensure secure communication services and exchange of data among healthcare professionals. However, there is a plethora of challenges in these healthcare PKI infrastructures. Especially, there are a lot of challenges for PKI infrastructures deployed over large-scale healthcare networks. In this paper, we propose a PKI infrastructure to ensure security in a large-scale Internet-based healthcare network connecting a wide spectrum of healthcare units geographically distributed within a wide region. Furthermore, the proposed PKI infrastructure facilitates the trust issues that arise in a large-scale healthcare network including multi-domain PKI infrastructures.

  19. Insights into Participants' Behaviours in Educational Games, Simulations and Workshops: A Catastrophe Theory Application to Motivation.

    Science.gov (United States)

    Cryer, Patricia

    1988-01-01

    Develops models for participants' behaviors in games, simulations, and workshops based on Catastrophe Theory and Herzberg's two-factor theory of motivation. Examples are given of how these models can be used, both for describing and understanding the behaviors of individuals, and for eliciting insights into why participants behave as they do. (11…

  20. Making Decisions about an Educational Game, Simulation or Workshop: A 'Game Theory' Perspective.

    Science.gov (United States)

    Cryer, Patricia

    1988-01-01

    Uses game theory to help practitioners make decisions about educational games, simulations, or workshops whose outcomes depend to some extent on chance. Highlights include principles for making decisions involving risk; elementary laws of probability; utility theory; and principles for making decisions involving uncertainty. (eight references)…

  1. Workshop on nuclear structure and decay data: Theory and evaluation manual - Pt. 2

    International Nuclear Information System (INIS)

    Nichols, A.L.; McLaughlin, P.K.; p.mclaughlin@iaea.org

    2004-11-01

    A two-week Workshop on Nuclear Structure and Decay Data: Theory and Evaluation was organized and administrated by the IAEA Nuclear Data Section, and hosted at the Abdus Salam International Centre for Theoretical Physics (ICTP) in Trieste, Italy from 17 to 28 November 2003. The aims and contents of this workshop are summarized, along with the agenda, list of participants, comments and recommendations. Workshop materials are also included that are freely available on CD-ROM (all relevant PowerPoint presentations and manuals along with appropriate computer codes). (author)

  2. Workshop on nuclear structure and decay data: Theory and evaluation manual - Pt. 1

    International Nuclear Information System (INIS)

    Nichols, A.L.; McLaughlin, P.K.; p.mclaughlin@iaea.org

    2004-11-01

    A two-week Workshop on Nuclear Structure and Decay Data: Theory and Evaluation was organized and administrated by the IAEA Nuclear Data Section, and hosted at the Abdus Salam International Centre for Theoretical Physics (ICTP) in Trieste, Italy from 17 to 28 November 2003. The aims and contents of this workshop are summarized, along with the agenda, list of participants, comments and recommendations. Workshop materials are also included that are freely available on CD-ROM (all relevant PowerPoint presentations and manuals along with appropriate computer codes). (author)

  3. DOE planning workshop on rf theory and computations

    International Nuclear Information System (INIS)

    1984-01-01

    The purpose of the two-day workshop-meeting was to review the status of rf heating in magnetic fusion plasmas and to determine the outstanding problems in this area. The term rf heating was understood to encompass not only bulk plasma heating by externally applied electromagnetic power but also current generation in toroidal plasmas and generation of thermal barriers in tandem mirror plasmas

  4. ES12; The 24th Annual Workshop on Recent Developments in Electronic Structure Theory

    Energy Technology Data Exchange (ETDEWEB)

    Holzwarth, Natalie [Wake Forest Univ., Winston-Salem, NC (United States); Thonhauser, Timo [Wake Forest Univ., Winston-Salem, NC (United States); Salam, Akbar [Wake Forest Univ., Winston-Salem, NC (United States)

    2012-06-29

    ES12: The 24th Annual Workshop on Recent Developments in Electronic Structure Theory was held June 5-8, 2012 at Wake Forest University in Winston-Salem, NC 27109. The program consisted of 24 oral presentations, 70 posters, and 2 panel discussions. The attendance of the Workshop was comparable to or larger than previous workshops and participation was impressively diverse. The 136 participants came from all over the world and included undergraduate students, graduate students, postdoctoral researchers, and senior scientists. The general assessment of the Workshop was extremely positive in terms of the high level of scientific presentations and discussions, and in terms of the schedule, accommodations, and affordability of the meeting.

  5. Workshop on Non-Associative & Non-Commutative Algebra and Operator Theory

    CERN Document Server

    Molina, Mercedes

    2016-01-01

    Presenting the collaborations of over thirty international experts in the latest developments in pure and applied mathematics, this volume serves as an anthology of research with a common basis in algebra, functional analysis and their applications. Special attention is devoted to non-commutative algebras, non-associative algebras, operator theory and ring and module theory. These themes are relevant in research and development in coding theory, cryptography and quantum mechanics. The topics in this volume were presented at the Workshop on Non-Associative & Non-Commutative Algebra and Operator Theory, held May 23—25, 2014 at Cheikh Anta Diop University in Dakar, Senegal in honor of Professor Amin Kaidi. The workshop was hosted by the university's Laboratory of Algebra, Cryptology, Algebraic Geometry and Applications, in cooperation with the University of Almería and the University of Málaga. Dr. Kaidi's work focuses on non-associative rings and algebras, operator theory and functional analysis, and he...

  6. Proceedings of the Johns Hopkins workshop on current problems in particle theory 5: unified field theories and beyond

    International Nuclear Information System (INIS)

    1981-01-01

    Topics covered include: symmetric gauge theories; infinite lie algebras in physics; the mechanism for confinement in massive quark QCD; a search for possible composite models of quarks and leptons; the radiative structure of Fermion masses; fractional electric charge in QCD; heavy particle effects; Fermion mass heirarchies in theories of technicolor; statistical notions applied in the early universe; grand unification and cosmology - an environmental impact statement; first order phase transition in the early universe; the electric dipole moment of the neutron; cosmological constraints on Grand Unified Theories; and the consequences for CP invariance of instanton angles THETA in dynamically broken gauge theories. Individual items from this workshop were prepared separately for the data base

  7. Invited and contributed papers presented by the theory group at the joint Varenna-Lausanne international workshop 'theory of fusion plasmas'

    International Nuclear Information System (INIS)

    1996-09-01

    In this report eight invited and contributed papers of the theory group are included which were presented at joint Varenna-Lausanne international workshop on 'theory of fusion plasmas'. (author) figs., tabs., refs

  8. Practising what we preach: using cognitive load theory for workshop design and evaluation.

    Science.gov (United States)

    Naismith, Laura M; Haji, Faizal A; Sibbald, Matthew; Cheung, Jeffrey J H; Tavares, Walter; Cavalcanti, Rodrigo B

    2015-12-01

    Theory-based instructional design is a top priority in medical education. The goal of this Show and Tell article is to present our theory-driven approach to the design of instruction for clinical educators. We adopted cognitive load theory as a framework to design and evaluate a series of professional development workshops that were delivered at local, national and international academic conferences in 2014. We used two rating scales to measure participants' cognitive load. Participants also provided narrative comments as to how the workshops could be improved. Cognitive load ratings from 59 participants suggested that the workshop design optimized learning by managing complexity for different levels of learners (intrinsic load), stimulating cognitive processing for long-term memory storage (germane load), and minimizing irrelevant distracters (extraneous load). Narrative comments could also be classified as representing intrinsic, extraneous, or germane load, which provided specific directions for ongoing quality improvement. These results demonstrate that a cognitive load theory approach to workshop design and evaluation is feasible and useful in the context of medical education.

  9. Algebraic K-theory and its applications. Proceedings of the workshop and symposium

    International Nuclear Information System (INIS)

    Bass, H.; Kuku, A.O.; Pedrini, C.

    1999-01-01

    The book contains 21 papers presented at the workshop (6 papers) and the symposium (15 papers) on 'Algebraic K-theory and its applications' held at the ICTP Trieste (Italy), between 1-19 September 1997. Four papers were considered within the INIS subject scope and indexed separately

  10. Impact of coalition interoperability on PKI

    Science.gov (United States)

    Krall, Edward J.

    2003-07-01

    This paper examines methods for providing PKI interoperability among units of a coalition of armed forces drawn from different nations. The area in question is tactical identity management, for the purposes of confidentiality, integrity and non-repudiation in such a dynamic coalition. The interoperating applications under consideration range from email and other forms of store-and-forward messaging to TLS and IPSEC-protected real-time communications. Six interoperability architectures are examined with advantages and disadvantages of each described in the paper.

  11. Workshop on foundations of the relativistic theory of atomic structure

    International Nuclear Information System (INIS)

    1981-03-01

    The conference is an attempt to gather state-of-the-art information to understand the theory of relativistic atomic structure beyond the framework of the original Dirac theory. Abstracts of twenty articles from the conference were prepared separately for the data base

  12. Workshop on low-dimensional quantum field theory and its applications

    International Nuclear Information System (INIS)

    Yamamoto, Hisashi

    1990-02-01

    The workshop on 'Low-Dimensional Quantum Field Theory and its Applications' was held at INS on December 18 - 20, 1989 with about seventy participants. Some pedagogical reviews and the latest results were delivered on the recent topics related to both solid-state and particle physics. Among them are quantum Hall effect, high T c superconductivity and related topics in low-dimensional quantum field theory. Many active discussions were made on these issues. (J.P.N.)

  13. PKI - Crawling Out of the Grave & Into the Arms of Government

    Science.gov (United States)

    D'Angio, Phil; Vassilliadas, Panos; Kaklamanis, Phaidon

    This paper will analyze the characteristics of successful PKI projects lead by Government organizations. The paper will examine a recent E-Government project based on PKI credentials as well as suggest the approach for Government PKI programs emphasize strong collaboration with non-government use cases. It also examines the characteristics of PKI projects that were not successful in the past, and their role in creating the industry analyst perception that PKI was dead.

  14. A Workshop on Algebraic Design Theory and Hadamard Matrices

    CERN Document Server

    2015-01-01

    This volume develops the depth and breadth of the mathematics underlying the construction and analysis of Hadamard matrices and their use in the construction of combinatorial designs. At the same time, it pursues current research in their numerous applications in security and cryptography, quantum information, and communications. Bridges among diverse mathematical threads and extensive applications make this an invaluable source for understanding both the current state of the art and future directions. The existence of Hadamard matrices remains one of the most challenging open questions in combinatorics. Substantial progress on their existence has resulted from advances in algebraic design theory using deep connections with linear algebra, abstract algebra, finite geometry, number theory, and combinatorics. Hadamard matrices arise in a very diverse set of applications. Starting with applications in experimental design theory and the theory of error-correcting codes, they have found unexpected and important ap...

  15. Proceedings of the 33rd International Workshop on Nuclear Theory (IWNT-33)

    International Nuclear Information System (INIS)

    Georgieva, A. I.; Minkov, N.

    2014-01-01

    The main topics of the 2014 Workshop: nuclear structure and reactions; symmetries and dynamics; collective and intrinsic motions of nuclei; exotic nuclei; few-body and many-fermion systems; nuclear astrophysics and related topics are part of the NTL’s program for basic nuclear physics research. This broad range of subjects gives a space for the participants to cover the most actual points of view relating the theory with experiment, providing interpretation and predictions, bridging interdisciplinary topics related to nuclear structure and reactions. The Workshop was attended by 42 participants from 19 scientific institutions of 11 countries

  16. Workshop on Thermal Field Theory to Neural Networks

    CERN Document Server

    Veneziano, Gabriele; Aurenche, Patrick

    1996-01-01

    Tanguy Altherr was a Fellow in the Theory Division at CERN, on leave from LAPP (CNRS) Annecy. At the time of his accidental death in July 1994, he was only 31.A meeting was organized at CERN, covering the various aspects of his scientific interests: thermal field theory and its applications to hot or dense media, neural networks and its applications to high energy data analysis. Speakers were among his closest collaborators and friends.

  17. International Workshop on Electronic Density Functional Theory : Recent Progress and New Directions

    CERN Document Server

    Vignale, Giovanni; Das, Mukunda

    1998-01-01

    This book is an outcome of the International Workshop on Electronic Density Functional Theory, held at Griffith University in Brisbane, Australia, in July 1996. Density functional theory, standing as it does at the boundary between the disciplines of physics, chemistry, and materials science, is a great mixer. Invited experts from North America, Europe, and Australia mingled with students from several disciplines, rapidly taking up the informal style for which Australia is famous. A list of participants is given at the end of the book. Density functional theory (DFT) is a subtle approach to the very difficult problem of predicting the behavior of many interacting particles. A major application is the study of many-electron systems. This was the workshop theme, embracing inter alia computational chemistry and condensed matter physics. DFT circumvents the more conceptually straightforward (but more computationally intensive) approach in which one solves the many-body Schrodinger equation. It relies instead on r...

  18. Understanding the Theory of Multiple Intelligences. Staff Workshop Handout

    Science.gov (United States)

    Early Childhood Today, 2005

    2005-01-01

    In his "Theory of Multiple Intelligences," Dr. Howard Gardner expands the concept of intelligence to include such areas as music, spatial relations, and interpersonal knowledge in addition to the traditional view of two intelligences--mathematical and linguistic. Using biological as well as cultural research, Gardner formulated a list of seven…

  19. Proceedings of the 34th International Workshop on Nuclear Theory (IWNT-34)

    International Nuclear Information System (INIS)

    Gaidarov, M.; Minkov, N.

    2015-01-01

    The 34th volume of the Nuclear Theory series contains articles based on the presentations given at the Thirty Fourth International Workshop on Nuclear Theory (IWNT-34) held from 21st to 27th of June 2015 in the Rila Mountains, Bulgaria. The main topics of the 2015 Workshop were: nuclear structure and reactions; symmetries and dynamics; collective and intrinsic motions of nuclei; exotic nuclei; few-body and many-fermion systems; nuclear astrophysics and related topics are part of the NTL’s program for basic nuclear physics research. This broad range of subjects gives a space for the participants to cover the most actual points of view relating the theory with experiment, providing interpretation and predictions, bridging interdisciplinary topics related to nuclear structure and reactions. The Workshop was attended by 25 participants (including the organizers) from 11 scientific institutions of 7 countries: Belgium, Bulgaria, Italy, France, Kazakhstan, Romania and Russia. The scientific program contained totally 16 oral talks and 3 posters

  20. Proceedings of the Johns Hopkins workshop on current problems in particle theory 5: unified field theories and beyond

    Energy Technology Data Exchange (ETDEWEB)

    1981-01-01

    Topics covered include: symmetric gauge theories; infinite lie algebras in physics; the mechanism for confinement in massive quark QCD; a search for possible composite models of quarks and leptons; the radiative structure of Fermion masses; fractional electric charge in QCD; heavy particle effects; Fermion mass heirarchies in theories of technicolor; statistical notions applied in the early universe; grand unification and cosmology - an environmental impact statement; first order phase transition in the early universe; the electric dipole moment of the neutron; cosmological constraints on Grand Unified Theories; and the consequences for CP invariance of instanton angles THETA in dynamically broken gauge theories. Individual items from this workshop were prepared separately for the data base. (GHT)

  1. Proceedings of the 30th International Workshop on Nuclear Theory (IWNT-30)

    International Nuclear Information System (INIS)

    Georgieva, A. I.; Minkov, N.

    2011-01-01

    The Thirtieth Anniversary International Workshop on Nuclear Theory was held between 27 June and 2 July 2011 in Rila Mountains, Bulgaria. The main topics of the program were: nucleon-nucleon correlation effects on nuclear structure and reactions; symmetries in nuclear structure; collective and intrinsic motions of nuclei; exotic nuclei; few-body systems; advanced studies of many-fermion systems; nuclear astrophysics and related topics. They are related to the problems contained in the research plan of the Nuclear Theory Laboratory of the Institute for Nuclear Research and Nuclear Energy of the Bulgarian Academy of Sciences. The Workshop was attended by 49 participants (including the organizers) from France, Germany, Greece, Italy, Japan, Kazakhstan, Romania, Russia, South Africa, Spain, USA and Bulgaria. The scientific program contained totally 32 oral talks. The schedule of the Workshop was organized so as to provide an opportunity for meetings and discussions among scientists with common interests as well as among physicists working in different fields of research. The secluded mountain area and the lovely forest venue allowed the participants to concentrate on their scientific work but also to refresh between the sessions and get an inspiration for future work development

  2. Public Key Infrastructure (PKI) Interoperability: A Security Services Approach to Support Transfer of Trust

    National Research Council Canada - National Science Library

    Hansen, Anthony

    1999-01-01

    .... This thesis defines interoperability as the capacity to support trust through retention of security services across PKI domains at a defined level of assurance and examines the elements of PKI...

  3. NATO Advanced Research Workshop on Time-Dependent Quantum Molecular Dynamics : Theory and Experiment

    CERN Document Server

    Lathouwers, L

    1992-01-01

    From March 30th to April 3rd, 1992, a NATO Advanced Research workshop entitled "Time Dependent Quantum Molecular Dynamics: Theory and Experiment" was held at Snowbird, Utah. The organizing committee consisted of J. BROECKHOVE (Antwerp, Belgium), L. CEDERBAUM (Heidelberg, Germany), L. LATHOUWERS (Antwerp, Belgium), N. OHRN (Gainesville, Florida) and J. SIMONS (Salt Lake City, Utah). Fifty-two participants from eleven different countries attended the meeting at which thirty-three talks and one poster session were held. Twenty-eight participants submitted contributions to the proceedings of the meeting, which are reproduced in this volume. The workshop brought together experts in different areas 0 f molecular quantum dynamics, all adhering to the time dependent approach. The aim was to discuss and compare methods and applications. The ~amiliarityo~ the aUdience with the concepts o~ time dependent approaches greatly facilitated topical discussions and probing towards new applications. A broad area of subject matt...

  4. PKI Implementation Issues: A Comparative Study of Pakistan with some Asian Countries

    OpenAIRE

    Malik, Nasir Mahmood; Khalil, Tehmina; Khalid, Samina; Malik, Faisal Munir

    2009-01-01

    The paper includes Public Key Infrastructure (PKI), its need and requirements and introduction of some renowned PKI products. However, the major thrust of this work is that how PKI can enhance security of various systems. The paper is intended to serve as a guide on how to adequately prepare for some of the challenges that may be encountered especially in developing countries like Pakistan. The detail of PKI implementation issues is also included in the paper along with future challenges rega...

  5. Sakata Memorial KMI Workshop on Origin of Mass and Strong Coupling Gauge Theories

    CERN Document Server

    ‎Maskawa, Toshihide; Nojiri, Shin'ichi; Tanabashi, Masaharu; Yamawaki, Koichi

    2018-01-01

    This volume contains contributions to the workshop, which was largely focused on the strong coupling gauge theories in search for theories beyond the standard model, particularly, the LHC experiments and lattice studies of conformal fixed point. The main topics include walking technicolor and the role of conformality in view of the 125 GeV Higgs as a light composite Higgs (technidilaton, and other composite Higgs, etc.). Nonperturbative studies like lattice simulations and stringy/holographic approaches are extensively discussed in close relation to the phenomenological studies. After the discovery of 125 GeV Higgs at LHC, the central issue of particle physics is now to reveal the dynamical origin of the Higgs itself. One of the possibilities would be the composite Higgs based on the strong coupling gauge theory in the TeV region, such as the technidilaton predicted in walking technicolor with infrared conformality. The volume contains, among others, many of the latest important reports on walking technicolo...

  6. VLASOVIA 2013 - International workshop on the theory and applications of Vlasov equation - Slides of the presentations

    International Nuclear Information System (INIS)

    Aunai, N.; Belmont, G.; Smets, R.; Chandre, C.; Tassi, E.; Morrison, P.J.; Back, A.; Guillebon, L. de; Qin, H.; Squire, J.; Tang, W.M.; Garbet, X.; Esteve, D.; Sarazin, Y.; Abiteboul, J.; Bourdelle, C.; Dif-Pradalier, G.; Ghendrih, P.; Grandgirard, V.; Latu, G.; Smolyakov, A.; Hervieux, P.A.; Manfredi, G.; Jasiak, R.; Kraus, M.; Mora, P.; Morel, P.; Dreydemy Ghiro, F.; Berionni, V.; Gurcan, O.D.; Morrison, P.J.; Negulescu, C.; Pegoraro, F.; Bulanov, S.V.; Califano, F.; Fedeli, L.; Grassi, A.; Macchi, A.; Petri, J.; Pezzi, O.; Valentini, F.; Perrone, D.; Veltri, P.; Taccogna, F.; Minelli, P.; Thide, B.; Tamburini, F.; Throumoulopoulos, G.; Tasso, H.

    2014-01-01

    The Vlasov equation is used for the modelling of a wide range of phenomena occurring in natural and man-made plasmas, as well as in other many-particle systems displaying a collective behaviour. The purpose of this workshop is to bring together scientists to discuss the latest results on Vlasov theory and related applications. The topics discussed include: space plasmas, inertial confinement plasmas, magnetic confinement plasmas, quantum effects in collisionless plasmas, gravitational systems, Hamiltonian Vlasov dynamics, and computational and numerical approaches. This document gathers the slides of the presentations.

  7. Development of a PET tracer for imaging EGFR tyrosine kinase: evaluation of the suitability of PKI166

    International Nuclear Information System (INIS)

    Kernchen, R.; Brust, P.; Krause, M.; Baumann, M.

    2002-01-01

    The suitability of PKI166 for the development of a PET tracer for imaging EGFR tyrosine kinase was investigated. Binding studies using EGFR positive tumour tissue and tritiated PKI166 as the radioligand indicated a low binding affinity of PKI166 to the target tissue. PKI166 is therefore not recommended for PET tracer development. (orig.)

  8. Design and implementation of PKI-based certification authority

    Science.gov (United States)

    Zheng, Ying; Bai, Qinghai; Zhao, Linna; Chun, Hua; Chen, Jing

    2015-12-01

    PKI achieves the management of public key by certificates. It combines the user's public key and his or her identification formation through a trusted third-party organization CA, in order to authenticate the user's identity on the Internet, thus ensuring the authenticity, integrity, confidentiality, and non- repudiation of the information transmitted on the Internet. CA is the most critical agency in the PKI system, mainly responsible for issuing and managing certificates. On the basis of the actual needs of an enterprise, in this paper the author designs and develops a small-sized PKI-based Certification Authority equipped with the functions of root CA initialization, certificate application, certificate issuance, certificate revocation, and the generation of certificate revocation list. The author also points out the problems that need to be mentioned in the design and development.

  9. Strong coupling gauge theories and effective field theories. Proceedings of the 2002 international workshop

    International Nuclear Information System (INIS)

    Harada, Masayasu; Kikukawa, Yoshio; Yamawaki, Koichi

    2003-01-01

    This issue presents the important recent progress in both theoretical and phenomenological issues of strong coupling gauge theories, with/without supersymmetry and extra dimensions, etc. Emphasis in a placed on dynamical symmetry breaking with large anomalous dimensions governed by the dynamics near the nontrivial fixed point. Also presented are recent developments of the corresponding effective field theories. The 43 of the presented papers are indexed individually. (J.P.N)

  10. RIKEN BNL RESEARCH CENTER WORKSHOP ON GAUGE-INVARIANT VARIABLES IN GAUGE THEORIES, VOLUME 20

    Energy Technology Data Exchange (ETDEWEB)

    VAN BAAL,P.; ORLAND,P.; PISARSKI,R.

    2000-06-01

    This four-day workshop focused on the wide variety of approaches to the non-perturbative physics of QCD. The main topic was the formulation of non-Abelian gauge theory in orbit space, but some other ideas were discussed, in particular the possible extension of the Maldacena conjecture to nonsupersymmetric gauge theories. The idea was to involve most of the participants in general discussions on the problem. Panel discussions were organized to further encourage debate and understanding. Most of the talks roughly fell into three categories: (1) Variational methods in field theory; (2) Anti-de Sitter space ideas; (3) The fundamental domain, gauge fixing, Gribov copies and topological objects (both in the continuum and on a lattice). In particular some remarkable progress in three-dimensional gauge theories was presented, from the analytic side by V.P. Nair and mostly from the numerical side by O. Philipsen. This work may ultimately have important implications for RHIC experiments on the high-temperature quark-gluon plasma.

  11. CONFERENCE DESCRIPTION Theory of Fusion Plasmas: Varenna-Lausanne International Workshop

    Science.gov (United States)

    Garbet, X.; Sauter, O.

    2010-12-01

    The Joint Varenna-Lausanne international workshop on Theory of Fusion Plasmas takes place every other year in a place particularly favourable for informal and in-depth discussions. Invited and contributed papers present state-of-the-art research in theoretical plasma physics, covering all domains relevant to fusion plasmas. This workshop always welcomes a fruitful mix of experienced researchers and students, to allow a better understanding of the key theoretical physics models and applications. Theoretical issues related to burning plasmas Anomalous Transport (Turbulence, Coherent Structures, Microinstabilities) RF Heating and Current Drive Macroinstabilities Plasma-Edge Physics and Divertors Fast particles instabilities Further details: http://Varenna-Lausanne.epfl.ch The conference is organized by: Centre de Recherches en Physique des Plasmas, Ecole Polytechnique Fédérale de Lausanne, Association EURATOM - Confédération Suisse 'Piero Caldirola' International Centre for the Promotion of Science and International School of Plasma Physics Istituto di Fisica del Plasma del CNR, Milano Editors: X Garbet (CEA, Cadarache, France) and O Sauter (CRPP-EPFL, Lausanne, Switzerland)

  12. Fifteenth international workshop on nuclear theory. Rila Mountains, Bulgaria, June 10-15, 1996. Abstracts

    International Nuclear Information System (INIS)

    1996-01-01

    This brochure contains the abstracts of reports delivered by 22 participants at the 15. International Workshop on Nuclear Theory organized by the Institute for Nuclear Research and Nuclear Energy, Bulgaria. The main topics discussed are: hot giant dipole resonance problem, nuclear dynamics in the phase space, heavy ion collisions, ground state correlations beyond RPA, short-range nucleon-nucleon correlation effects in various applications (semiclassical models, magnetic form factors, nucleon momentum distributions, charge densities), nucleon-nucleon interactions in the frame of the semiclassical distorted wave model and O(8) model , nuclear surface in preequilibrium reactions at low energies, magnetic excitations in deformed nuclei, particle decay and E2 transitions, fragmentation at near-barrier energies in heavy ion reactions, IBM models, representations of deformed groups and HF method. All items are recorded in INIS separately

  13. Proceedings First Workshop on Quantitative Formal Methods : theory and applications (QFM'09, Eindhoven, The Netherlands, November 3, 2009)

    NARCIS (Netherlands)

    Andova, S.; McIver, A.; D'Argenio, P.R.; Cuijpers, P.J.L.; Markovski, J.; Morgan, C.; Núñez, M.

    2009-01-01

    This volume contains the papers presented at the 1st workshop on Quantitative Formal Methods: Theory and Applications, which was held in Eindhoven on 3 November 2009 as part of the International Symposium on Formal Methods 2009. This volume contains the final versions of all contributions accepted

  14. Compact Toroid Theory Planning Workshop. A panel report to the Director, Division of Applied Plasma Physics, Office of Fusion Energy

    International Nuclear Information System (INIS)

    1980-07-01

    The purpose of the Workshop was to identify the most important physics issues that need to be addressed in the near term in order to assure the optimal design and timely interpretation of Compact Toroid (CT) experiments. The Panel was also asked to assess the levels of effort required to obtain priority information on appropriate time scales compatible with DOE plans to design a CT proof-of-principle experiment. The fiscal year cost anticipated for the effort recommended by the Workshop Panel (excluding costs for computing) is estimated to be approximately $5.7M. CT theory is currently funded at a level of approximately $2.0M per year

  15. THEORY AND PRACTICE IN THE WORKSHOP OF EXPRESSION VISUAL-GRAPHICS FOR MULTIPLIERS - DAC / UFSC.

    Directory of Open Access Journals (Sweden)

    Richard Perassi Sousa

    2010-12-01

    Full Text Available This paper presents theoretical reasons and procedures that structure the practices of free artistic expression in working with adolescents and adults. The goal is to identify and justify the theory, pedagogical methods and the practical activities developed with the multipliers for the release of graphic and plastic expression, as an exercise in personal expression within a social context. The method adopted provides a theoretical justification and development activities of artistic expression-visual graph, as a field of significant interaction between subject and his inner universe. These activities are motivated by the need for expression, which is inherent in human beings, requiring the participants' ministrator and planning and organization. Therefore, beyond the scope of self-expressive, the proposed activities serve as the organizing principle subject to significant social and working life. Here are the relevant issues included the theoretical and practical theories "Free Expression" and "Education through Art." The procedures described here were developed with teachers, artists and other participants of "Workshop of expression visual-graphics for multipliers" held at the Departamento de Arte e Cultura (DAC / UFSC within the Project Arte na Escola in the years 2008 and 2009.

  16. Authentication in Virtual Organizations: A Reputation Based PKI Interconnection Model

    Science.gov (United States)

    Wazan, Ahmad Samer; Laborde, Romain; Barrere, Francois; Benzekri, Abdelmalek

    Authentication mechanism constitutes a central part of the virtual organization work. The PKI technology is used to provide the authentication in each organization involved in the virtual organization. Different trust models are proposed to interconnect the different PKIs in order to propagate the trust between them. While the existing trust models contain many drawbacks, we propose a new trust model based on the reputation of PKIs.

  17. Pengembangan Game Edukatif G30S/PKI Berbasis Android

    Directory of Open Access Journals (Sweden)

    Annisa Hedlina Hendraputri

    2014-11-01

    Full Text Available Gaya hidup masyarakat zaman sekarang tak pernah lepas dari kemajuan teknologi. Masyarakat menengah keatas, baik dari anak-anak hingga orang dewasa, hampir tidak ada yang tidak meggunakan perangkat mobile seperti handphone atau tablet. Namun sayangnya masyarakat zaman sekarang cenderung apatis dengan kondisi sekitarnya, bahkan tidak mengenal sejarah negaranya. Penelitian ini dilakukan untuk mendekatkan kembali anak-anak dengan sejarah terutama peristiwa G30S/PKI melalui game perangkat seluler berbasis Android. Penelitian ini dilakukan dengan menerapkan tahap pengembangan MDLC (Multimedia Development Life Cycle mulai dari tahap penentuan konsep sampai dengan sidtribusi. Sebagai sumber yang relevan, cerita sejarah diambil langsung dari Monumen Pancasila Sakti di Lubang Buaya, Jakarta Timur, sebagai salah satu tempat bersejarah yang erat kaitannya dengan peristiwa G30S/PKI. Hasil dari penelitian ini berupa suatu aplikasi permainan yang menceritakan peristiwa sejarah G30S/PKI yang dikemas menjadi aplikasi perangkat seluler dengan sistem operasi Android. Penelitian ini diharapkan mampu menarik minat anak-anak khususnya usia 9 sampai dengan 12 tahun untuk mempelajari dan mencintai sejarah Indonesia.

  18. Joint Varenna-Lausanne International Workshop on the Theory of Fusion Plasmas 2016

    International Nuclear Information System (INIS)

    2016-01-01

    The joint Varenna-Lausanne international workshop on the theory of fusion plasmas took place in Varenna from August 29 to September 2 2016. Several issues of interest for fusion plasmas were addressed, namely MHD stability, RF heating, collisional and turbulent transport, plasma wall interaction, and physics of burning plasmas. The articles published in this special issue illustrate nicely the well balanced combination of physics, applied mathematics, and computer sciences that characterizes this workshop. Let us mention several attractive topics, which are addressed in this issue. The question of 3D MHD equilibrium in tokamaks has received a great deal of attention, in connection with external resonant magnetic perturbations in tokamaks, and also stochastic edge in stellarators. The reader will also find some recent developments related to the effect of current drive and heating on the stability of tearing modes. As usual, turbulent transport is addressed in much detail. Several papers address specific numerical aspects of fluid and gyrokinetic codes, including code optimisation. Physics issues are abundantly dealt with, such as the impact of fast particles on turbulence, and particle transport. New numerical techniques to model wave propagation are presented, which provide significant advances in the field. Refinements such as the effect of density fluctuation on wave propagation, or the interaction between particles and the electromagnetic field near antennas, have also been studied in depth. Finally, specific issues such as nonlocal transport, decay of zonal flows, and the effect of neutrals on rotation have been investigated. A striking feature of the 2016 edition was the large number of young faces among the participants. This is a great satisfaction for the organizers since a new generation of scientists is certainly needed whilst several devices come to operation, or will do so in a foreseeable future. The diversity and quality of the papers published in

  19. 8th international workshop on plasma edge theory in fusion devices. Abstracts of invited and contributed papers

    International Nuclear Information System (INIS)

    Sipilae, S.K.; Heikkinen, J.A.

    2001-01-01

    The 8th International Workshop on Plasma Edge Theory in Fusion Devices, held at Dipoli Congress Centre, Espoo, Finland, is organised on behalf of the International Scientific Committee by Helsinki University of Technology and VTT (Technical Research Centre of Finland). Similar to the seven preceding Workshops, it addresses the theory for the boundary layer of magnetically confined fusion plasmas. It reflects the present status of the theory for the edge region of fusion plasmas. Emphasis is placed on the development of theory and of appropriate numerical methods as well as on self-consistent modelling of experimental data (including also empirical elements). The following topics are covered: basic edge plasma theory, models of special phenomena and edge control, and integrated edge plasma modelling. The International Scientific Committee has selected the papers and compiled the scientific programme. All other arrangements have been made by the Local Organising Committee. The Workshop is supported by the European Commission, High-Level Scientific Conferences. This Book of Abstracts contains the scientific programme and the abstracts of the invited and contributed papers. The Workshop has seven invited lectures of 60 minutes duration (including 10 minutes for discussion). In addition, 10 contributed papers were selected for oral presentation of 30 minutes duration (including five minutes for discussion). All oral presentations are given in plenary sessions. The remaining 34 contributed papers are presented as posters in three sessions. The invited lectures and contributed oral papers are presented also as posters. All invited and contributed papers will be refereed and published also as a regular issue of the journal Contributions to Plasma Physics. (orig.)

  20. Expression of PKA inhibitor (PKI) gene abolishes cAMP-mediated protection to endothelial barrier dysfunction.

    Science.gov (United States)

    Lum, H; Jaffe, H A; Schulz, I T; Masood, A; RayChaudhury, A; Green, R D

    1999-09-01

    We investigated the hypothesis that cAMP-dependent protein kinase (PKA) protects against endothelial barrier dysfunction in response to proinflammatory mediators. An E1-, E3-, replication-deficient adenovirus (Ad) vector was constructed containing the complete sequence of PKA inhibitor (PKI) gene (AdPKI). Infection of human microvascular endothelial cells (HMEC) with AdPKI resulted in overexpression of PKI. Treatment with 0.5 microM thrombin increased transendothelial albumin clearance rate (0.012 +/- 0.003 and 0.035 +/- 0.005 microl/min for control and thrombin, respectively); the increase was prevented with forskolin + 3-isobutyl-1-methylxanthine (F + I) treatment. Overexpression of PKI resulted in abrogation of the F + I-induced inhibition of the permeability increase. However, with HMEC infected with ultraviolet-inactivated AdPKI, the F + I-induced inhibition was present. Also, F + I treatment of HMEC transfected with reporter plasmid containing the cAMP response element-directed transcription of the luciferase gene resulted in an almost threefold increase in luciferase activity. Overexpression of PKI inhibited this induction of luciferase activity. The results show that Ad-mediated overexpression of PKI in endothelial cells abrogated the cAMP-mediated protection against increased endothelial permeability, providing direct evidence that cAMP-dependent protein kinase promotes endothelial barrier function.

  1. Workshop on nuclear structure and decay data: Theory and evaluation, 2008

    International Nuclear Information System (INIS)

    Nichols, A.L.; McLaughlin, P.K.

    2008-06-01

    A two-week Workshop on Nuclear Structure and Decay Data under the auspices of the IAEA Nuclear Data Section was organised and held at the Abdus Salam International Centre for Theoretical Physics (ICTP) in Trieste, Italy from 28 April to 9 May 2008. This workshop constituted a further development of previous Nuclear Structure and Decay Data Workshops held in 2002, 2003, 2005 and 2006. The aims and contents of the 2008 workshop are summarized, along with the agenda, list of participants, comments and recommendations. All recent workshop material has been assembled in this INDC report, and is also freely available on CD-ROM (all relevant PowerPoint presentations and manuals along with appropriate computer codes). (author)

  2. Spectral theory of Sturm-Liouville differential operators: proceedings of the 1984 workshop

    Energy Technology Data Exchange (ETDEWEB)

    Kaper, H.G.; Zettl, A. (eds.)

    1984-12-01

    This report contains the proceedings of the workshop which was held at Argonne during the period May 14 through June 15, 1984. The report contains 22 articles, authored or co-authored by the participants in the workshop. Topics covered at the workshop included the asymptotics of eigenvalues and eigenfunctions; qualitative and quantitative aspects of Sturm-Liouville eigenvalue problems with discrete and continuous spectra; polar, indefinite, and nonselfadjoint Sturm-Liouville eigenvalue problems; and systems of differential equations of Sturm-Liouville type.

  3. Workshop report on large-scale matrix diagonalization methods in chemistry theory institute

    Energy Technology Data Exchange (ETDEWEB)

    Bischof, C.H.; Shepard, R.L.; Huss-Lederman, S. [eds.

    1996-10-01

    The Large-Scale Matrix Diagonalization Methods in Chemistry theory institute brought together 41 computational chemists and numerical analysts. The goal was to understand the needs of the computational chemistry community in problems that utilize matrix diagonalization techniques. This was accomplished by reviewing the current state of the art and looking toward future directions in matrix diagonalization techniques. This institute occurred about 20 years after a related meeting of similar size. During those 20 years the Davidson method continued to dominate the problem of finding a few extremal eigenvalues for many computational chemistry problems. Work on non-diagonally dominant and non-Hermitian problems as well as parallel computing has also brought new methods to bear. The changes and similarities in problems and methods over the past two decades offered an interesting viewpoint for the success in this area. One important area covered by the talks was overviews of the source and nature of the chemistry problems. The numerical analysts were uniformly grateful for the efforts to convey a better understanding of the problems and issues faced in computational chemistry. An important outcome was an understanding of the wide range of eigenproblems encountered in computational chemistry. The workshop covered problems involving self- consistent-field (SCF), configuration interaction (CI), intramolecular vibrational relaxation (IVR), and scattering problems. In atomic structure calculations using the Hartree-Fock method (SCF), the symmetric matrices can range from order hundreds to thousands. These matrices often include large clusters of eigenvalues which can be as much as 25% of the spectrum. However, if Cl methods are also used, the matrix size can be between 10{sup 4} and 10{sup 9} where only one or a few extremal eigenvalues and eigenvectors are needed. Working with very large matrices has lead to the development of

  4. Proliferation marker pKi-67 affects the cell cycle in a self-regulated manner.

    Science.gov (United States)

    Schmidt, Mirko H H; Broll, Rainer; Bruch, Hans-Peter; Duchrow, Michael

    2002-01-01

    The proliferation marker pKi-67 is commonly used in research and pathology to detect proliferating cells. In a previous work, we found the protein to be associated with regulators of the cell cycle, controlling S-phase progression, as well as entry into and exit from mitosis. Here we investigate whether pKi-67 has a regulative effect on the cell cycle itself. For that purpose we cloned four fragments of pKi-67, together representing nearly the whole protein, and an N-terminal pKi-67 antisense oligonucleotide into a tetracycline inducible gene expression system. The sense fragments were C-terminally modified by addition of either a nuclear localization sequence (NLS) or a STOP codon to address the impact of their intracellular distribution. FACS based cell cycle analysis revealed that expression of nearly all pKi-67 domains and the antisense oligonucleotide led to a decreased amount of cells in S-phase and an increased number of cells in G(2)/M- and G(1)-phase. Subsequent analysis of the endogenous pKi-67 mRNA and protein levels revealed that the constructs with the most significant impact on the cell cycle were able to silence pKi-67 transcription as well. We conclude from the data that pKi-67 influences progression of S-phase and mitosis in a self-regulated manner and, therefore, effects the cell cycle checkpoints within both phases. Furthermore, we found pKi-67 mediates an anti-apoptotic effect on the cell and we verified that this marker, although it is a potential ribosomal catalyst, is not expressed in differentiated tissues with a high transcriptional activity. Copyright 2002 Wiley-Liss, Inc.

  5. PREFACE: 4th Workshop on Theory, Modelling and Computational Methods for Semiconductors (TMCSIV)

    Science.gov (United States)

    Tomić, Stanko; Probert, Matt; Migliorato, Max; Pal, Joydeep

    2014-06-01

    These conference proceedings contain the written papers of the contributions presented at the 4th International Conference on Theory, Modelling and Computational Methods for Semiconductor materials and nanostructures. The conference was held at the MediaCityUK, University of Salford, Manchester, UK on 22-24 January 2014. The previous conferences in this series took place in 2012 at the University of Leeds, in 2010 at St William's College, York and in 2008 at the University of Manchester, UK. The development of high-performance computer architectures is finally allowing the routine use of accurate methods for calculating the structural, thermodynamic, vibrational, optical and electronic properties of semiconductors and their hetero- and nano-structures. The scope of this conference embraces modelling, theory and the use of sophisticated computational tools in semiconductor science and technology, where there is substantial potential for time-saving in R&D. Theoretical approaches represented in this meeting included: Density Functional Theory, Semi-empirical Electronic Structure Methods, Multi-scale Approaches, Modelling of PV devices, Electron Transport, and Graphene. Topics included, but were not limited to: Optical Properties of Quantum Nanostructures including Colloids and Nanotubes, Plasmonics, Magnetic Semiconductors, Photonic Structures, and Electronic Devices. This workshop ran for three days, with the objective of bringing together UK and international leading experts in the theoretical modelling of Group IV, III-V and II-VI semiconductors, as well as students, postdocs and early-career researchers. The first day focused on providing an introduction and overview of this vast field, aimed particularly at students, with several lectures given by recognized experts in various theoretical approaches. The following two days showcased some of the best theoretical research carried out in the UK in this field, with several contributions also from representatives of

  6. PREFACE: 3rd Workshop on Theory, Modelling and Computational Methods for Semiconductors (TMCSIII)

    Science.gov (United States)

    Califano, Marco; Migliorato, Max; Probert, Matt

    2012-05-01

    These conference proceedings contain the written papers of the contributions presented at the 3rd International Conference on Theory, Modelling and Computational Methods for Semiconductor materials and nanostructures. The conference was held at the School of Electronic and Electrical Engineering, University of Leeds, Leeds, UK on 18-20 January 2012. The previous conferences in this series took place in 2010 at St William's College, York and in 2008 at the University of Manchester, UK. The development of high-speed computer architectures is finally allowing the routine use of accurate methods for calculating the structural, thermodynamic, vibrational, optical and electronic properties of semiconductors and their hetero- and nano-structures. The scope of this conference embraces modelling, theory and the use of sophisticated computational tools in semiconductor science and technology, where there is substantial potential for time-saving in R&D. Theoretical approaches represented in this meeting included: Density Functional Theory, Tight Binding, Semiempirical Pseudopotential Methods, Effective Mass Models, Empirical Potential Methods and Multiscale Approaches. Topics included, but were not limited to: Optical and Transport Properties of Quantum Nanostructures including Colloids and Nanotubes, Plasmonics, Magnetic Semiconductors, Graphene, Lasers, Photonic Structures, Photovoltaic and Electronic Devices. This workshop ran for three days, with the objective of bringing together UK and international leading experts in the theoretical modelling of Group IV, III-V and II-VI semiconductors, as well as students, postdocs and early-career researchers. The first day focused on providing an introduction and overview of this vast field, aimed particularly at students, with several lectures given by recognised experts in various theoretical approaches. The following two days showcased some of the best theoretical research carried out in the UK in this field, with several

  7. The PKI in West Timor and Nusa Tenggara Timur 1965 and beyond

    Directory of Open Access Journals (Sweden)

    Steven Farram

    2010-12-01

    Full Text Available This paper examines the aftermath in West Timor and elsewhere in the province of Nusa Tenggara Timur (NTT, of the 30 September 1965 ‘coup’ in Jakarta that resulted in the banning of the Indonesian Communist Party (PKI and the large-scale killing of its members and associates. An assessment is given of PKI strength in NTT in 1965, along with an analysis of the killings, including the numbers killed, who carried out the killings, who was targeted, and the fate of those captured, but not killed. Consideration is also given to the ongoing effects in NTT of accusations of PKI membership.

  8. From the theory to practice: Five years of urban regeneration workshops

    Directory of Open Access Journals (Sweden)

    Raimundo Bambó-Naya

    2018-05-01

    Full Text Available The aim of this communication is to present the experience of four academic courses in the subject of Integrated Urban and Landscape Design, taught in the framework of the Master in Architecture of the School of Engineering and Architecture of the University of Zaragoza. It addresses urban regeneration interventions in vulnerable areas of the consolidated city with approaches to teaching innovation in the academic field and in the topic of user participation. The workshop methodology is explained in detail, paying more attention to the process followed than to the specific results of the workshop. The different stages of the process are presented: previous phase and selection of the study area, phase of analysis and diagnosis, phase of proposals, where a joint work is carried out with vision of action in the whole of the neighbourhood, and phase of presentation of the results to the Neighbours. Finally, some future challenges of this workshop are outlined.

  9. Applying Instructional Design Theories to Bioinformatics Education in Microarray Analysis and Primer Design Workshops

    Science.gov (United States)

    Shachak, Aviv; Ophir, Ron; Rubin, Eitan

    2005-01-01

    The need to support bioinformatics training has been widely recognized by scientists, industry, and government institutions. However, the discussion of instructional methods for teaching bioinformatics is only beginning. Here we report on a systematic attempt to design two bioinformatics workshops for graduate biology students on the basis of…

  10. High Energy Theory Workshops and Visitors at the Michigan Center for Theoretical Physics FY16

    Energy Technology Data Exchange (ETDEWEB)

    Pierce, Aaron [Univ. of Michigan, Ann Arbor, MI (United States)

    2017-08-04

    This award provided partial support for the Michigan Center for Theoretical Physics to host two workshops "Beyond the Standard Model 2016" in October 2016, and the "5th MCTP Symposium: Foundations of String Cosmology" in April 2017 on the University of Michigan campus.

  11. Public Key Infrastructure (PKI) Interoperability: A Security Services Approach to Support Transfer of Trust

    National Research Council Canada - National Science Library

    Hansen, Anthony

    1999-01-01

    Public key infrastructure (PKI) technology is at a primitive stage characterized by deployment of PKIs that are engineered to support the provision of security services within individual enterprises, and are not able to support...

  12. Installation, Configuration and Operational Testing of a PKI Certificate Server and Its Supporting Services

    National Research Council Canada - National Science Library

    Ambers, Vanessa

    2004-01-01

    Public key infrastructure (PKI) was created to provide the basic services of confidentiality, authenticity, integrity and non-repudiation for sensitive information that may traverse public (un-trusted) networks...

  13. Approach for Business Case Analysis of Using PKI on Smart Cards for Governmentwide Applications

    National Research Council Canada - National Science Library

    2001-01-01

    Booz Allen & Hamilton, under contract to the General Services Administration, was tasked to document a business case approach that can be utilized by Federal agencies considering an investment in Public Key Infrastructure (PKI...

  14. 76 FR 126 - Requirement for Commercial Users To Use Commercial Public Key Information (PKI) Certificate

    Science.gov (United States)

    2011-01-03

    ... DEPARTMENT OF DEFENSE Department of the Army Requirement for Commercial Users To Use Commercial..., SDDC will require all commercial accounts accessing transportation systems and applications to use a commercial PKI certificate or Transportation Workers Identification Credential (TWIC). This requirement will...

  15. Chromatin preferences of the perichromosomal layer constituent pKi-67.

    Science.gov (United States)

    Traut, Walther; Endl, Elmar; Garagna, Silvia; Scholzen, Thomas; Schwinger, Eberhard; Gerdes, Johannes; Winking, Heinz

    2002-01-01

    The proliferation-associated nuclear protein pKi-67 relocates from the nucleolus to the chromosome surface during the G2/M transition of the cell cycle and contributes to the formation of the 'perichromosomal layer'. We investigated the in-vivo binding preferences of pKi-67 for various chromatin blocks of the mitotic chromosomes from the human and two mouse species, Mus musculus and M. caroli. All chromosomes were decorated with pKi-67 but displayed a gap of pKi-67 decoration in the centromere and NOR regions. pKi-67 distribution in a rearranged mouse chromosome showed that the formation of the centromeric gap was controlled by the specific chromatin in that region. While most chromatin served as a substrate for direct or indirect binding of pKi-67, we identified three types of chromatin that bound less or no pKi-67. These were: (1) the centromeric heterochromatin defined by the alpha satellite DNA in the human, by the mouse minor satellite in M. musculus and the 60- and 79-bp satellites in M. caroli; (2) the pericentromeric heterochromatin in M. musculus defined by the mouse major satellite, and (3) NORs in the human and in M. musculus defined by rDNA repeats. In contrast, the conspicuous blocks of pericentromeric heterochromatin in human chromosomes 1, 9 and 16 containing the 5-bp satellite showed intense pKi-67 decoration. The centromeric gap may have a biological significance for the proper attachment of the chromosomes to the mitotic spindle. In this context, our results suggest a new role for centromeric heterochromatin: the control of the centromeric gap in the perichromosomal layer.

  16. Proliferation marker pKi-67 occurs in different isoforms with various cellular effects.

    Science.gov (United States)

    Schmidt, Mirko H H; Broll, Rainer; Bruch, Hans-Peter; Finniss, Susan; Bögler, Oliver; Duchrow, Michael

    2004-04-15

    The Ki-67 antigen, pKi-67, is a commonly used proliferation marker in research and pathology. It has been recognized that the protein exists in two different splice variants that differ in one exon. In the current work, we present three new splice variants of human pKi-67 consisting of two naturally occurring isoforms and one atypical version. Additionally, data is presented indicating that alternative splicing of the pKi-67 N-terminus is common in tumor cell lines. Analyzing 93 tissues mainly consisting of brain tumor specimens, we found evidence that long and short isoform can be expressed independently of each other. Induction of mitosis in human peripheral blood mononuclear cells revealed that short pKi-67 appears earlier in the cell cycle than the long isoform and reaches its expression maximum when transcription of the latter sets in. Finally, transfection of mammalian culture cells with exon 7 (specific for the long pKi-67 isoform and not present in the short isoform) in a tetracycline regulated expression system decreased the rate of cell proliferation without affecting the cell cycle. In summary, we present evidence that the pKi-67 N-terminus is differentially spliced resulting in at least five different isoforms with different functions. Copyright 2004 Wiley-Liss, Inc.

  17. Suppression of cell division by pKi-67 antisense-RNA and recombinant protein.

    Science.gov (United States)

    Duchrow, M; Schmidt, M H; Zingler, M; Anemüller, S; Bruch, H P; Broll, R

    2001-01-01

    The human antigen defined by the monoclonal antibody Ki-67 (pKi-67) is a human nuclear protein strongly associated with cell proliferation and found in all tissues studied. It is widely used as a marker of proliferating cells, yet its function is unknown. To investigate its function we suppressed pKi-67 expression by antisense RNA and overexpressed a partial structure of pKi-67 in HeLa cells. A BrdU-incorporation assay showed a significant decrease in DNA synthesis after antisense inhibition. Cell cycle analysis indicated a higher proportion of cells in G1 phase and a lower proportion of cells in S phase while the number of G(2)/M phase cells remained constant. Overexpression of a recombinant protein encoding three of the repetitive elements from exon 13 of pKi-67 had a similar effect to that obtained by antisense inhibition. The similarity of the effect of expressing 'Ki-67 repeats' and pKi-67 antisense RNA could be explained by a negative effect on the folding of the endogenous protein in the endoplasmatic reticulum. Furthermore excessive self-association of pKi-67 via the repeat structure could inhibit its nuclear transport, preventing it from getting to its presumptive site of action. We conclude that the Ki-67 protein has an important role in the regulation of the cell cycle, which is mediated in part by its repetitive elements. Copyright 2001 S. Karger AG, Basel

  18. Proceedings of the 32nd International Workshop on Nuclear Theory (IWNT-32)

    International Nuclear Information System (INIS)

    Georgieva, A. I.; Minkov, N.

    2013-01-01

    The main topics of the 2013 Workshop were: Nuclear structure and reactions; Symmetries and dynamics; Collective and intrinsic motions of nuclei; Exotic nuclei; Few-body and many-fermion systems; Nuclear astrophysics and related topics. Most of them are part of the NTL’s program for basic nuclear physics research. However, they were kept open for participants from a much broader area of interests bridging with novel experimental developments, interdisciplinary topics related to nuclear structure and reactions, as well as, nuclear physics applications like nuclear safety. For the first time we had a participant from the Kozloduy Nuclear Power Plant as well as a lecturer giving a talk on nuclear reactor safety. The Workshop was attended by 42 participants (including the organizers) from India, Italy, Germany, UK, Hungary, Poland, Spain, Russia, Kazakhstan, Uzbekistan, South Africa, USA and Bulgaria. The scientific program contained totally 30 oral talks and 1 poster

  19. Using workshops to develop theories of change in five low and middle income countries: lessons from the programme for improving mental health care (PRIME)

    Science.gov (United States)

    2014-01-01

    Background The Theory of Change (ToC) approach has been used to develop and evaluate complex health initiatives in a participatory way in high income countries. Little is known about its use to develop mental health care plans in low and middle income countries where mental health services remain inadequate. Aims ToC workshops were held as part of formative phase of the Programme for Improving Mental Health Care (PRIME) in order 1) to develop a structured logical and evidence-based ToC map as a basis for a mental health care plan in each district; (2) to contextualise the plans; and (3) to obtain stakeholder buy-in in Ethiopia, India, Nepal, South Africa and Uganda. This study describes the structure and facilitator’s experiences of ToC workshops. Methods The facilitators of the ToC workshops were interviewed and the interviews were recorded, transcribed and analysed together with process documentation from the workshops using a framework analysis approach. Results Thirteen workshops were held in the five PRIME countries at different levels of the health system. The ToC workshops achieved their stated goals with the contributions of different stakeholders. District health planners, mental health specialists, and researchers contributed the most to the development of the ToC while service providers provided detailed contextual information. Buy-in was achieved from all stakeholders but valued more from those in control of resources. Conclusions ToC workshops are a useful approach for developing ToCs as a basis for mental health care plans because they facilitate logical, evidence based and contextualised plans, while promoting stakeholder buy in. Because of the existing hierarchies within some health systems, strategies such as limiting the types of participants and stratifying the workshops can be used to ensure productive workshops. PMID:24808923

  20. Research methodology workshops evaluation using the Kirkpatrick's model: translating theory into practice.

    Science.gov (United States)

    Abdulghani, Hamza Mohammad; Shaik, Shaffi Ahamed; Khamis, Nehal; Al-Drees, Abdulmajeed Abdulrahman; Irshad, Mohammad; Khalil, Mahmoud Salah; Alhaqwi, Ali Ibrahim; Isnani, Arthur

    2014-04-01

    Qualitative and quantitative evaluation of academic programs can enhance the development, effectiveness, and dissemination of comparative quality reports as well as quality improvement efforts. To evaluate the five research methodology workshops through assessing participants' satisfaction, knowledge and skills gain and impact on practices by the Kirkpatrick's evaluation model. The four level Kirkpatrick's model was applied for the evaluation. Training feedback questionnaires, pre and post tests, learner development plan reports and behavioral surveys were used to evaluate the effectiveness of the workshop programs. Of the 116 participants, 28 (24.1%) liked with appreciation, 62 (53.4%) liked with suggestions and 26 (22.4%) disliked the programs. Pre and post MCQs tests mean scores showed significant improvement of relevant basic knowledge and cognitive skills by 17.67% (p ≤ 0.005). Pre-and-post tests scores on workshops sub-topics also significantly improved for the manuscripts (p ≤ 0.031) and proposal writing (p ≤ 0.834). As for the impact, 56.9% of participants started research, and 6.9% published their studies. The results from participants' performance revealed an overall positive feedback and 79% of participant reported transfer of training skills at their workplace. The course outcomes achievement and suggestions given for improvements offer insight into the program which were encouraging and very useful. Encouraging "research culture" and work-based learning are probably the most powerful determinants for research promotion. These findings therefore encourage faculty development unit to continue its training and development in the research methodology aspects.

  1. Summary of workshop 'Theory Meets Industry' - the impact of ab initio solid state calculations on industrial materials research

    International Nuclear Information System (INIS)

    Wimmer, E

    2008-01-01

    A workshop, 'Theory Meets Industry', was held on 12-14 June 2007 in Vienna, Austria, attended by a well balanced number of academic and industrial scientists from America, Europe, and Japan. The focus was on advances in ab initio solid state calculations and their practical use in industry. The theoretical papers addressed three dominant themes, namely (i) more accurate total energies and electronic excitations (ii) more complex systems, and (iii) more diverse and accurate materials properties. Hybrid functionals give some improvements in energies, but encounter difficulties for metallic systems. Quantum Monte Carlo methods are progressing, but no clear breakthrough is on the horizon. Progress in order-N methods is steady, as is the case for efficient methods for exploring complex energy hypersurfaces and large numbers of structural configurations. The industrial applications were dominated by materials issues in energy conversion systems, the quest for hydrogen storage materials, improvements of electronic and optical properties of microelectronic and display materials, and the simulation of reactions on heterogeneous catalysts. The workshop is a clear testimony that ab initio computations have become an industrial practice with increasingly recognized impact

  2. Summary of workshop 'Theory Meets Industry'—the impact of ab initio solid state calculations on industrial materials research

    Science.gov (United States)

    Wimmer, E.

    2008-02-01

    A workshop, 'Theory Meets Industry', was held on 12-14 June 2007 in Vienna, Austria, attended by a well balanced number of academic and industrial scientists from America, Europe, and Japan. The focus was on advances in ab initio solid state calculations and their practical use in industry. The theoretical papers addressed three dominant themes, namely (i) more accurate total energies and electronic excitations, (ii) more complex systems, and (iii) more diverse and accurate materials properties. Hybrid functionals give some improvements in energies, but encounter difficulties for metallic systems. Quantum Monte Carlo methods are progressing, but no clear breakthrough is on the horizon. Progress in order-N methods is steady, as is the case for efficient methods for exploring complex energy hypersurfaces and large numbers of structural configurations. The industrial applications were dominated by materials issues in energy conversion systems, the quest for hydrogen storage materials, improvements of electronic and optical properties of microelectronic and display materials, and the simulation of reactions on heterogeneous catalysts. The workshop is a clear testimony that ab initio computations have become an industrial practice with increasingly recognized impact.

  3. 25th Johns Hopkins Workshop on Current Problems in Particle Theory

    CERN Document Server

    Dominici, Daniele; Lusanna, L

    2001-01-01

    This volume offers a comprehensive overview of our understanding of gravity at both the experimental and the theoretical level. Critical reviews by experts cover topics ranging from astrophysics (anisotropies in the cosmic microwave background, gamma ray bursts, neutron stars and astroparticles), cosmology, the status of gravitational wave sources and detectors, verification of Newton's law at short distances, the equivalence principle, gravito-magnetism, measurement theory, time machines and the foundations of Einstein's theory, to string theory and loop quantum gravity.

  4. Understanding Australian policies on public health using social and political science theories: reflections from an Academy of the Social Sciences in Australia Workshop.

    Science.gov (United States)

    Baum, Fran; Graycar, Adam; Delany-Crowe, Toni; de Leeuw, Evelyne; Bacchi, Carol; Popay, Jennie; Orchard, Lionel; Colebatch, Hal; Friel, Sharon; MacDougall, Colin; Harris, Elizabeth; Lawless, Angela; McDermott, Dennis; Fisher, Matthew; Harris, Patrick; Phillips, Clare; Fitzgerald, Jane

    2018-04-19

    There is strong, and growing, evidence documenting health inequities across the world. However, most governments do not prioritize policies to encourage action on the social determinants of health and health equity. Furthermore, despite evidence concerning the benefits of joined-up, intersectoral policy to promote health and health equity, it is rare for such policy approaches to be applied systematically. To examine the usefulness of political and social science theory in understanding the reasons for this disjuncture between evidence and practice, researchers and public servants gathered in Adelaide for an Academy of the Social Sciences in Australia (ASSA) Workshop. This paper draws together the learnings that emerged from the Workshop, including key messages about the usefulness of various theories as well as insights drawn from policy practice. Discussions during the Workshop highlighted that applying multiple theories is particularly helpful in directing attention to, and understanding, the influence of all stages of the policy process; from the construction and framing of policy problems, to the implementation of policy and evaluation of outcomes, including those outcomes that may be unintended. In addition, the Workshop emphasized the value of collaborations among public health researchers, political and social scientists and public servants to open up critical discussion about the intersections between theory, research evidence and practice. Such critique is vital to render visible the processes through which particular sources of knowledge may be privileged over others and to examine how political and bureaucratic environments shape policy proposals and implementation action.

  5. Report on the Willi Hennig Society workshop "Phylogenetic analysis: theory and practice" at the Institute of Botany Academy of Sciences of the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Drábková, Lenka; Pačes, Václav

    2008-01-01

    Roč. 24, č. 1 (2008), s. 108-109 ISSN 0748-3007 Institutional research plan: CEZ:AV0Z60050516; CEZ:AV0Z50520701; CEZ:AV0Z50520514 Keywords : phylogeny workshop * phylogenetic programmes * theory and practise Subject RIV: EF - Botanics Impact factor: 3.515, year: 2008

  6. Application of PKI in health care--needs, ambitions, prospects.

    Science.gov (United States)

    Suselj, Marjan; Marcun, Tomaz; Trcek, Denis; Kandus, Gorazd

    2003-01-01

    Through continual development and considerable investment over the past years, Slovenia has established an information infrastructure providing efficient data links between all the health care actors. This includes furnishing all the citizens and health workers with microprocessor cards--health insurance card and health professional card. These tools have significantly simplified different procedures in the health care and brought services closer to insured persons. The know-how and experiences gathered to day have given rise to vivid discussions of further development steps: introduction of new contents on the infrastructure in place and technological upgrading, in particular progressive incorporation of the PKI concept and thereby integration of card and network solutions to provide an efficient and secure communication environment. This paper outlines key perspectives of the future developments in this segment. With the volume of health care data communications through internet growing steeply, and with the paramount importance of patient--doctor trust and confidence, security tools and solutions in the health care are a critical need.

  7. J-PAKE: Authenticated Key Exchange without PKI

    Science.gov (United States)

    Hao, Feng; Ryan, Peter

    Password Authenticated Key Exchange (PAKE) is one of the important topics in cryptography. It aims to address a practical security problem: how to establish secure communication between two parties solely based on a shared password without requiring a Public Key Infrastructure (PKI). After more than a decade of extensive research in this field, there have been several PAKE protocols available. The EKE and SPEKE schemes are perhaps the two most notable examples. Both techniques are however patented. In this paper, we review these techniques in detail and summarize various theoretical and practical weaknesses. In addition, we present a new PAKE solution called J-PAKE. Our strategy is to depend on well-established primitives such as the Zero-Knowledge Proof (ZKP). So far, almost all of the past solutions have avoided using ZKP for the concern on efficiency. We demonstrate how to effectively integrate the ZKP into the protocol design and meanwhile achieve good efficiency. Our protocol has comparable computational efficiency to the EKE and SPEKE schemes with clear advantages on security.

  8. Three-dimensional organization of pKi-67: a comparative fluorescence and electron tomography study using FluoroNanogold.

    Science.gov (United States)

    Cheutin, Thierry; O'Donohue, Marie-Françoise; Beorchia, Adrien; Klein, Christophe; Kaplan, Hervé; Ploton, Dominique

    2003-11-01

    The monoclonal antibody (MAb) Ki-67 is routinely used in clinical studies to estimate the growth fraction of tumors. However, the role of pKi-67, the protein detected by the Ki-67 MAb, remains elusive, although some biochemical data strongly suggest that it might organize chromatin. To better understand the functional organization of pKi-67, we studied its three-dimensional distribution in interphase cells by confocal microscopy and electron tomography. FluoroNanogold, a single probe combining a dense marker with a fluorescent dye, was used to investigate pKi-67 organization at the optical and ultrastructural levels. Observation by confocal microscopy followed by 3D reconstruction showed that pKi-67 forms a shell around the nucleoli. Double labeling experiments revealed that pKi-67 co-localizes with perinucleolar heterochromatin. Electron microscopy studies confirmed this close association and demonstrated that pKi-67 is located neither in the fibrillar nor in the granular components of the nucleolus. Finally, spatial analyses by electron tomography showed that pKi-67 forms cords 250-300 nm in diameter, which are themselves composed of 30-50-nm-thick fibers. These detailed comparative in situ analyses strongly suggest the involvement of pKi-67 in the higher-order organization of perinucleolar chromatin.

  9. THE PKI-FDR UPRISING OF 1948 AND US POLICY REGARDING THE DUTCH-INDONESIAN DISPUTE

    Directory of Open Access Journals (Sweden)

    Richard Mason

    2009-01-01

    Full Text Available This paper contends that the abortive PKI-FDR uprising in Indonesia during the last quarter of 1948 marked an important turning point in the American policy toward the Indonesian struggle for independence against the Dutch. Before 1948, American policy toward Southeast Asia was almost exclusively dictated by the imperatives of European considerations, hence was pro-Dutch. The outbreak of the PKI-FDR not only raised the scepter of Communism in Indonesia but also underscored the belief Indonesian nationalism had to be settled in a just and practical way as a precondition to fight communism. In the final analysis, however, it cannot be said that the PKI-FDR revolt was ultimately responsible for the American decision to support the Indonesians. When threat of sanction was finally instituted against the Dutch, it was again European considerations which dictate the move.

  10. A cGMP kinase mutant with increased sensitivity to the protein kinase inhibitor peptide PKI(5-24).

    Science.gov (United States)

    Ruth, P; Kamm, S; Nau, U; Pfeifer, A; Hofmann, F

    1996-01-01

    Synthetic peptides corresponding to the active domain of the heat-stable inhibitor protein PKI are very potent inhibitors of cAMP-dependent protein kinase, but are extremely weak inhibitors of cGMP-dependent protein kinase. In this study, we tried to confer PKI sensitivity to cGMP kinase by site-directed mutagenesis. The molecular requirements for high affinity inhibition by PKI were deduced from the crystal structure of the cAMP kinase/PKI complex. A prominent site of interaction are residues Tyr235 and Phe239 in the catalytic subunit, which from a sandwich-like structure with Phe10 of the PKI(5-24) peptide. To increase the sensitivity for PKI, the cGMP kinase codons at the corresponding sites, Ser555 and Ser559, were changed to Tyr and Phe. The mutant cGMP kinase was stimulated half maximally by cGMP at 3-fold higher concentrations (240 nM) than the wild type (77 nM). Wild type and mutant cGMP kinase did not differ significantly in their Km and Vmax for three different substrate peptides. The PKI(5-24) peptide inhibited phosphotransferase activity of the mutant cGMP kinase with higher potency than that of wild type, with Ki values of 42 +/- .3 microM and 160 +/- .7 microM, respectively. The increased affinity of the mutant cGMP kinase was specific for the PKI(5-24) peptide. Mutation of the essential Phe10 in the PKI(5-24) sequence to an Ala yielded a peptide that inhibited mutant and wild type cGMP kinase with similar potency, with Ki values of 160 +/- 11 and 169 +/- 27 microM, respectively. These results suggest that the mutations Ser555Tyr and Ser559Phe are required, but not sufficient, for high affinity inhibition of cGMP kinase by PKI.

  11. Workshop on Control Theory Applied to Renewable Resource Management and Ecology

    CERN Document Server

    Skowronski, Janislaw

    1981-01-01

    As society becomes stressed by economic and population pressures, in turn, nature's renewable resources become stressed by harvesting pressures. For our own survival and euphoria, it is paramount that such resources remain as their name implies and not be driven to extinction through short term programs of over exploitation. Consideration of the harvesting of renewable resources leads to a simple question that was the theme of the workshop and is the focus of these proceedings: SUPPoRe you are assigned the role of manager for a specific renewable resource eco­ system. How would you decide on harvesting policies so that the system can be exploited economically yet at the same time maintain the integrity of the system? This, of course, is a loaded question. First of all, it is not clear that there is ever anyone single decision maker who is able to set the rules for all of the harvesters in an exploited ecosystem. The political process is complicated and to some extent unpredictable. This aspect of the questio...

  12. Binding-dependent disorder-order transition in PKI alpha: a fluorescence anisotropy study.

    Science.gov (United States)

    Hauer, J A; Taylor, S S; Johnson, D A

    1999-05-25

    The conformational flexibility of peptidyl ligands may be an essential element of many peptide-macromolecular interactions. Consequently, the alpha-carbonyl backbone flexibility of the 8 kDa protein kinase inhibitor (PKI alpha) peptide of cAMP-dependent protein kinase (cAPK) free in solution and bound to cAPK was assessed by time-resolved fluorescence anisotropy. Specifically, three full-length, single-site PKI alpha mutants (V3C, S28C, and S59C) were prepared, and fluorescein iodoacetamide (FI) was selectively conjugated to the side chains of each substituted cysteine. The time-resolved anisotropy decay profiles of the labeled mutants were well fit to a model-free nonassociative biexponential equation. Free in solution, the three labeled proteins had very similar anisotropy decays arising primarily from local alpha-carbonyl backbone movements. Only a small fraction of the anisotropy decay was associated with slower, whole-body tumbling, confirming that PKI alpha is highly disordered at all three locations. Complexation of the mutants with the catalytic (C) subunit of cAPK decreased the rate of whole-body tumbling for all three mutants. The effects on the rapid decay processes, however, were dependent upon the site of conjugation. The anisotropy decay profiles of both FI-V3C- and FI-S28C-PKI alpha were associated with significantly reduced contributions from the fast decay processes, while that of FI-S59C-PKI alpha was largely unaffected by binding to the C-subunit. The results suggest that the cAPK-binding domain of PKI alpha extends from the its N-terminus to residues beyond Ser28 but does not include the segment around Ser59, which is still part of a highly flexible domain when bound to the C-subunit.

  13. Summary for theory and general session at the RHIC detector workshop

    International Nuclear Information System (INIS)

    Kahana, S.

    1985-01-01

    The topics summarized include: cascade codes treating the components of nuclei as nucleons; a quark gluon cascade code; a treatment of shocks, detonation, and deflagration; putting finite density on the lattice as well as treating the phase transition at a finite critical temperature for vanishing density; theory for dilepton and photon signals and a treatment of the approach to equilibrium; the hydrodynamic evolution of the quark-gluon plasma; and QCD hydrodynamics. 13 refs., 7 figs

  14. Theory, modeling and instrumentation for materials by design: Proceedings of workshop

    Energy Technology Data Exchange (ETDEWEB)

    Allen, R.E.; Cocke, D.L.; Eberhardt, J.J.; Wilson, A. (eds.)

    1984-01-01

    The following topics are contained in this volume: how can materials theory benefit from supercomputers and vice-versa; the materials of xerography; relationship between ab initio and semiempirical theories of electronic structure and renormalization group and the statistical mechanics of polymer systems; ab initio calculations of materials properties; metals in intimate contact; lateral interaction in adsorption: revelations from phase transitions; quantum model of thermal desorption and laser stimulated desorption; extended fine structure in appearance potential spectroscopy as a probe of solid surfaces; structural aspects of band offsets at heterojunction interfaces; multiconfigurational Green's function approach to quantum chemistry; wavefunctions and charge densities for defects in solids: a success for semiempirical theory; empirical methods for predicting the phase diagrams of intermetallic alloys; theoretical considerations regarding impurities in silicon and the chemisorption of simple molecules on Ni; improved Kohn-Sham exchange potential; structural stability calculations for films and crystals; semiempirical molecular orbital modeling of catalytic reactions including promoter effects; theoretical studies of chemical reactions: hydrolysis of formaldehyde; electronic structure calculations for low coverage adlayers; present status of the many-body problem; atomic scattering as a probe of physical adsorption; and, discussion of theoretical techniques in quantum chemistry and solid state physics.

  15. MFGA-IDT2 workshop: Astrophysical and geophysical fluid mechanics: the impact of data on turbulence theories

    Science.gov (United States)

    Schertzer, D.; Falgarone, E.

    appropriate editorial structure, in particular a large number of editors covering a wide range of methodologies, expertises and schools. At least two of its sections (Scaling and Multifractals, Turbulence and Diffusion) were directly related to the topics of the workshop, in any case contributors were invited to choose their editor freely. 2 Goals of the Workshop The objective of this meeting was to enhance the confrontation between turbulence theories and empirical data from geophysics and astrophysics fluids with very high Reynolds numbers. The importance of these data seems to have often been underestimated for the evaluation of theories of fully developed turbulence, presumably due to the fact that turbulence does not appear as pure as in laboratory experiments. However, they have the great advantage of giving access not only to very high Reynolds numbers (e.g. 1012 for atmospheric data), but also to very large data sets. It was intended to: (i) provide an overview of the diversity of potentially available data, as well as the necessary theoretical and statistical developments for a better use of these data (e.g. treatment of anisotropy, role of processes which induce other nonlinearities such as thermal instability, effect of magnetic field and compressibility ... ), (ii) evaluate the means of discriminating between different theories (e.g. multifractal intermittency models) or to better appreciate the relevance of different notions (e.g. Self-Organized Criticality) or phenomenology (e.g. filaments, structures), (iii) emphasise the different obstacles, such as the ubiquity of catastrophic events, which could be overcome in the various concerned disciplines, thanks to theoretical advances achieved. 3 Outlines of the Workshop During the two days of the workshop, the series of presentations covered many manifestations of turbulence in geophysics, including: oceans, troposphere, stratosphere, very high atmosphere, solar wind, giant planets, interstellar clouds... up to the

  16. MFGA-IDT2 workshop: Astrophysical and geophysical fluid mechanics: the impact of data on turbulence theories

    Directory of Open Access Journals (Sweden)

    D. Schertzer

    1996-01-01

    . It had an appropriate editorial structure, in particular a large number of editors covering a wide range of methodologies, expertises and schools. At least two of its sections (Scaling and Multifractals, Turbulence and Diffusion were directly related to the topics of the workshop, in any case contributors were invited to choose their editor freely. 2 Goals of the Workshop The objective of this meeting was to enhance the confrontation between turbulence theories and empirical data from geophysics and astrophysics fluids with very high Reynolds numbers. The importance of these data seems to have often been underestimated for the evaluation of theories of fully developed turbulence, presumably due to the fact that turbulence does not appear as pure as in laboratory experiments. However, they have the great advantage of giving access not only to very high Reynolds numbers (e.g. 1012 for atmospheric data, but also to very large data sets. It was intended to: (i provide an overview of the diversity of potentially available data, as well as the necessary theoretical and statistical developments for a better use of these data (e.g. treatment of anisotropy, role of processes which induce other nonlinearities such as thermal instability, effect of magnetic field and compressibility ... , (ii evaluate the means of discriminating between different theories (e.g. multifractal intermittency models or to better appreciate the relevance of different notions (e.g. Self-Organized Criticality or phenomenology (e.g. filaments, structures, (iii emphasise the different obstacles, such as the ubiquity of catastrophic events, which could be overcome in the various concerned disciplines, thanks to theoretical advances achieved. 3 Outlines of the Workshop During the two days of the workshop, the series of presentations covered many manifestations of turbulence in geophysics, including: oceans, troposphere, stratosphere, very high atmosphere, solar wind, giant planets, interstellar clouds

  17. Association of pKi-67 with satellite DNA of the human genome in early G1 cells.

    Science.gov (United States)

    Bridger, J M; Kill, I R; Lichter, P

    1998-01-01

    pKi-67 is a nucleolar antigen that provides a specific marker for proliferating cells. It has been shown previously that pKi-67's distribution varies in a cell cycle-dependent manner: it coats all chromosomes during mitosis, accumulates in nuclear foci during G1 phase (type I distribution) and localizes within nucleoli in late G1 S and G2 phase (type II distribution). Although no function has as yet been ascribed to pKi-67, it has been found associated with centromeres in G1. In the present study the distribution pattern of pKi-67 during G1 in human dermal fibroblasts (HDFs) was analysed in more detail. Synchronization experiments show that in very early G1 cells pKi-67 coincides with virtually all satellite regions analysed, i.e. with centromeric (alpha-satellite), telomeric (minisatellite) and heterochromatic blocks (satellite III) on chromosomes 1 and Y (type Ia distribution). In contrast, later in the G1 phase, a smaller fraction of satellite DNA regions are found collocalized with pKi-67 foci (type Ib distribution). When all pKi-67 becomes localized within nucleoli, even fewer satellite regions remain associated with the pKi-67 staining. However, all centromeric and short arm regions of the acrocentric chromosomes, which are in very close proximity to or even contain the rRNA genes, are collocalized with anti-pKi-67 staining throughout the remaining interphase of the cell cycle. Thus, our data demonstrate that during post-mitotic reformation and nucleogenesis there is a progressive decline in the fraction of specific satellite regions of DNA that remain associated with pKi-67. This may be relevant to nucleolar reformation following mitosis.

  18. Protein kinase inhibitor peptide (PKI): a family of endogenous neuropeptides that modulate neuronal cAMP-dependent protein kinase function.

    Science.gov (United States)

    Dalton, George D; Dewey, William L

    2006-02-01

    Signal transduction cascades involving cAMP-dependent protein kinase are highly conserved among a wide variety of organisms. Given the universal nature of this enzyme it is not surprising that cAMP-dependent protein kinase plays a critical role in numerous cellular processes. This is particularly evident in the nervous system where cAMP-dependent protein kinase is involved in neurotransmitter release, gene transcription, and synaptic plasticity. Protein kinase inhibitor peptide (PKI) is an endogenous thermostable peptide that modulates cAMP-dependent protein kinase function. PKI contains two distinct functional domains within its amino acid sequence that allow it to: (1) potently and specifically inhibit the activity of the free catalytic subunit of cAMP-dependent protein kinase and (2) export the free catalytic subunit of cAMP-dependent protein kinase from the nucleus. Three distinct PKI isoforms (PKIalpha, PKIbeta, PKIgamma) have been identified and each isoform is expressed in the brain. PKI modulates neuronal synaptic activity, while PKI also is involved in morphogenesis and symmetrical left-right axis formation. In addition, PKI also plays a role in regulating gene expression induced by cAMP-dependent protein kinase. Future studies should identify novel physiological functions for endogenous PKI both in the nervous system and throughout the body. Most interesting will be the determination whether functional differences exist between individual PKI isoforms which is an intriguing possibility since these isoforms exhibit: (1) cell-type specific tissue expression patterns, (2) different potencies for the inhibition of cAMP-dependent protein kinase activity, and (3) expression patterns that are hormonally, developmentally and cell-cycle regulated. Finally, synthetic peptide analogs of endogenous PKI will continue to be invaluable tools that are used to elucidate the role of cAMP-dependent protein kinase in a variety of cellular processes throughout the nervous

  19. PKI, Gamma Radiation Reactor Shielding Calculation by Point-Kernel Method

    International Nuclear Information System (INIS)

    Li Chunhuai; Zhang Liwu; Zhang Yuqin; Zhang Chuanxu; Niu Xihua

    1990-01-01

    1 - Description of program or function: This code calculates radiation shielding problem of gamma-ray in geometric space. 2 - Method of solution: PKI uses a point kernel integration technique, describes radiation shielding geometric space by using geometric space configuration method and coordinate conversion, and makes use of calculation result of reactor primary shielding and flow regularity in loop system for coolant

  20. A PKI Approach for Deploying Modern Secure Distributed E-Learning and M-Learning Environments

    Science.gov (United States)

    Kambourakis, Georgios; Kontoni, Denise-Penelope N.; Rouskas, Angelos; Gritzalis, Stefanos

    2007-01-01

    While public key cryptography is continuously evolving and its installed base is growing significantly, recent research works examine its potential use in e-learning or m-learning environments. Public key infrastructure (PKI) and attribute certificates (ACs) can provide the appropriate framework to effectively support authentication and…

  1. PKI development in Estonia : issues of concern / Ksenia Melnikova, Karlis Kreslins

    Index Scriptorium Estoniae

    Melnikova, Ksenia

    2001-01-01

    Kaanel ajak. ilmumisaeg Winter 2001/2002. Probleemidest avaliku võtme infrastruktuuri arendamisel (public key infrastructure - PKI) Eestis. Puudus on kompetentsetest spetsialistidest, informatsiooni vähesuse tõttu pole olnud laiemat arutelu rahastamise teemal, probleemiks on erinevate süsteemide ühildamine

  2. PKI development in Estonia : issues of concern / Ksenia Melnikova, Karlis Kreslins

    Index Scriptorium Estoniae

    Melnikova, Ksenia

    2002-01-01

    Kaanel ajak. ilmumisaeg 2001/2002. Probleemidest avaliku võtme infrastruktuuri arendamisel (public key infrastructure - PKI) Eestis. Puudus on kompetentsetest spetsialistidest, informatsiooni vähesuse tõttu pole olnud laiemat arutelu rahastamise teemal, probleemiks on erinevate süsteemide ühildamine

  3. NATO Advanced Research Workshop on The Theory of Chemical Reaction Dynamics

    CERN Document Server

    1986-01-01

    The calculation of cross sections and rate constants for chemical reactions in the gas phase has long been a major problem in theoretical chemistry. The need for reliable and applicable theories in this field is evident when one considers the significant recent advances that have been made in developing experimental techniques, such as lasers and molecular beams, to probe the microscopic details of chemical reactions. For example, it is now becoming possible to measure cross sections for chemical reactions state selected in the vibrational­ rotational states of both reactants and products. Furthermore, in areas such as atmospheric, combustion and interstellar chemistry, there is an urgent need for reliable reaction rate constant data over a range of temperatures, and this information is often difficult to obtain in experiments. The classical trajectory method can be applied routinely to simple reactions, but this approach neglects important quantum mechanical effects such as tunnelling and resonances. For al...

  4. "Loops and Legs in Quantum Field Theory", 12th DESY Workshop on Elementary Particle Physics

    Science.gov (United States)

    The bi-annual international conference "Loops and Legs in Quantum Field Theory" has been held at Weimar, Germany, from April 27 to May 02, 2014. It has been the 12th conference of this series, started in 1992. The main focus of the conference are precision calculations of multi- loop and multi-leg processes in elementary particle physics for processes at present and future high-energy facilities within and beyond the Standard Model. At present many physics questions studied deal with processes at the LHC and future facilities like the ILC. A growing number of contributions deals with important developments in the field of computational technologies and algorithmic methods, including large-scale computer algebra, efficient methods to compute large numbers of Feynman diagrams, analytic summation and integration methods of various kinds, new related function spaces, precise numerical methods and Monte Carlo simulations. The present conference has been attended by more than 110 participants from all over the world, presenting more than 75 contributions, most of which have been written up for these pro- ceedings. The present volume demonstrates in an impressive way the enormous development of the field during the last few years, reaching the level of 5-loop calculations in QCD and a like- wise impressive development in massive next-to-leading order and next-to-next-to-leading order processes. Computer algebraic and numerical calculations require terabyte storage and many CPU years, even after intense parallelization, to obtain state-of-the-art theoretical predictions. The city of Weimar gave a suitable frame to the conference, with its rich history, especially in literature, music, arts, and architecture. Goethe, Schiller, Wieland, Herder, Bach and Liszt lived there and created many of their masterpieces. The many young participants signal that our field is prosperous and faces an exciting future. The conference hotel "Kaiserin Augusta" offered a warm hospitality and

  5. Urbanist workshops between theory and practice: The importance of spatial and programme reference levels in the planning method

    OpenAIRE

    Gregor Čok

    2013-01-01

    One of the key characteristics of urban-architectural workshops as a soft planning method is above all the fact that the authors are free of burden of formal facts and reference levels of the local environment, which do not influence the concept and the working process. Within this framework, the workshop presents an opportunity for the creator to focus primarily on the core of the problem, and work creatively towards a substantiated professional solution. In addition to the basic ref...

  6. Chromophore-assisted light inactivation of pKi-67 leads to inhibition of ribosomal RNA synthesis.

    Science.gov (United States)

    Rahmanzadeh, R; Hüttmann, G; Gerdes, J; Scholzen, T

    2007-06-01

    Expression of the nuclear Ki-67 protein (pKi-67) is strongly associated with cell proliferation. For this reason, antibodies against this protein are widely used as prognostic tools for the assessment of cell proliferation in biopsies from cancer patients. Despite this broad application in histopathology, functional evidence for the physiological role of pKi-67 is still missing. Recently, we proposed a function of pKi-67 in the early steps of ribosomal RNA (rRNA) synthesis. Here, we have examined the involvement of pKi-67 in this process by photochemical inhibition using chromophore-assisted light inactivation (CALI). Anti-pKi-67 antibodies were labelled with the fluorochrome fluorescein 5(6)-isothiocyanate and were irradiated after binding to their target protein. Performing CALI in vitro on cell lysates led to specific cross-linking of pKi-67. Moreover, the upstream binding factor (UBF) necessary for rRNA transcription was also partly subjected to cross-link formation, indicating a close spatial proximity of UBF and pKi-67. CALI in living cells, using micro-injected antibody, caused a striking relocalization of UBF from foci within the nucleoli to spots located at the nucleolar rim or within the nucleoplasm. pKi-67-CALI resulted in dramatic inhibition of RNA polymerase I-dependent nucleolar rRNA synthesis, whereas RNA polymerase II-dependent nucleoplasmic RNA synthesis remained almost unaltered. Our data presented here argue for a crucial role of pKi-67 in RNA polymerase I-dependent nucleolar rRNA synthesis.

  7. PKI-587 and sorafenib alone and in combination on inhibition of liver cancer stem cell proliferation.

    Science.gov (United States)

    Gedaly, Roberto; Galuppo, Roberto; Musgrave, Yolanda; Angulo, Paul; Hundley, Jonathan; Shah, Malay; Daily, Michael F; Chen, Changguo; Cohen, Donald A; Spear, Brett T; Evers, B Mark

    2013-11-01

    Deregulated Ras/Raf/mitogen-activated protein kinase and PI3 K/AKT/mTOR signaling pathways are significant in hepatocellular carcinoma proliferation (HCC). In this study we evaluated differences in the antiproliferative effect of dual PI3 K/Akt/mTOR and Ras/Raf/mitogen-activated protein kinase inhibition of non liver cancer stem cell lines (PLC and HuH7) and liver cancer stem cell (LCSC) lines (CD133, CD44, CD24, and aldehyde dehydrogenase 1-positive cells). Flow cytometry was performed on the resulting tumors to identify the LCSC markers CD133, CD44, CD24, and aldehyde dehydrogenase 1. Methylthiazol tetrazolium assay was used to assess cellular proliferation. Finally, a Western blot assay was used to evaluate for inhibition of specific enzymes in these two signaling pathways. Using flow cytometry, we found that LCSC contain 64.4% CD133 + cells, 83.2% CD44 + cells, and 96.4% CD24 + cells. PKI-587 and sorafenib caused inhibiton of LCSC and HCC cell proliferation. PLC cells were more sensitive to PKI-587 than LCSC or Huh7 (P PKI-587 and sorafenib caused significantly more inhibition than monotherapy in HuH7, PLC, and LCSC. Using the methylthiazol tetrazolium assay, we found that the LCSC proliferation was inhibited with sorafenib monotherapy 39% at 5 μM (P PKI-587 at 0.1 μM (P = 0.002, n = 12) compared with control. The combination of PKI-587 and sorafenib, however, synergistically inhibited LCSC proliferation by 86% (P = 0.002; n = 12). LCSC (CD133+, CD44+, CD24+) were able to develop very aggressive tumors with low cell concentrations at 4 to 6 wk. Cells CD133+, CD44+, CD24+, which demonstrated at least moderate resistance to therapy in vitro. The combination of PKI-587 and sorafenib was better than either drug alone at inhibiting of LCSC and on HCC cell proliferation. Copyright © 2013 Elsevier Inc. All rights reserved.

  8. Tissue-specific expression and regulation by 1,25(OH)2D3 of chick protein kinase inhibitor (PKI) mRNA.

    Science.gov (United States)

    Marchetto, G S; Henry, H L

    1997-02-01

    The heat-stable protein kinase inhibitor (PKI) protein is a specific and potent competitive inhibitor of the catalytic subunit of cAMP-dependent protein kinase (PKA). Previously, it has been shown that vitamin D status affects chick kidney PKI activity: a 5- to 10-fold increase in PKI activity was observed in kidneys of chronically vitamin D-deficient chicks and treatment with 1,25-dihydroxyvitamin D3 (1,25[OH]2D3) in cultured kidney cells resulted in a 95% decrease in PKI activity. The authors have recently cloned the cDNA for chick kidney PKI and have used the coding sequence to study the regulation of PKI mRNA. Northern analysis showed the expression of two PKI messages, which are 2.7 and 3.3 kb in size. These mRNAs are expressed in brain, muscle, testis, and kidney, but not in pancreas, liver, or intestine. PKI mRNA steady-state levels are downregulated by 47% in kidneys from vitamin D-replete chicks as compared to vitamin D-deficient chicks. PKI mRNA levels in brain, muscle, and testis are not affected by vitamin D status. Treatment of primary chick kidney cultures treated with 10(-7) M 1,25(OH)2D3 for 24h resulted in a 20-30% decrease in PKI mRNA. 1,25(OH)2D3 treatment does not affect the stability of PKI mRNA as determined by treatment of cell cultures with actinomycin D. This study shows that 1,25(OH)2D3 directly and tissue-specifically downregulates PKI mRNA in the chick kidney.

  9. Antitumor efficacy of PKI-587, a highly potent dual PI3K/mTOR kinase inhibitor.

    Science.gov (United States)

    Mallon, Robert; Feldberg, Larry R; Lucas, Judy; Chaudhary, Inder; Dehnhardt, Christoph; Santos, Efren Delos; Chen, Zecheng; dos Santos, Osvaldo; Ayral-Kaloustian, Semiramis; Venkatesan, Aranapakam; Hollander, Irwin

    2011-05-15

    The aim of this study was to show preclinical efficacy and clinical development potential of PKI-587, a dual phosphoinositide 3-kinase (PI3K)/mTOR inhibitor. In vitro class 1 PI3K enzyme and human tumor cell growth inhibition assays and in vivo five tumor xenograft models were used to show efficacy. In vitro, PKI-587 potently inhibited class I PI3Ks (IC(50) vs. PI3K-α = 0.4 nmol/L), PI3K-α mutants, and mTOR. PKI-587 inhibited growth of 50 diverse human tumor cell lines at IC(50) values of less than 100 nmol/L. PKI-587 suppressed phosphorylation of PI3K/mTOR effectors (e.g., Akt), and induced apoptosis in human tumor cell lines with elevated PI3K/mTOR signaling. MDA-MB-361 [breast; HER2(+), PIK3CA mutant (E545K)] was particularly sensitive to this effect, with cleaved PARP, an apoptosis marker, induced by 30 nmol/L PKI-587 at 4 hours. In vivo, PKI-587 inhibited tumor growth in breast (MDA-MB-361, BT474), colon (HCT116), lung (H1975), and glioma (U87MG) xenograft models. In MDA-MB-361 tumors, PKI-587 (25 mg/kg, single dose i.v.) suppressed Akt phosphorylation [at threonine(T)308 and serine(S)473] for up to 36 hours, with cleaved PARP (cPARP) evident up to 18 hours. PKI-587 at 25 mg/kg (once weekly) shrank large (∼1,000 mm(3)) MDA-MB-361 tumors and suppressed tumor regrowth. Tumor regression correlated with suppression of phosphorylated Akt in the MDA-MB-361 model. PKI-587 also caused regression in other tumor models, and efficacy was enhanced when given in combination with PD0325901 (MEK 1/2 inhibitor), irinotecan (topoisomerase I inhibitor), or HKI-272 (neratinib, HER2 inhibitor). Significant antitumor efficacy and a favorable pharmacokinetic/safety profile justified phase 1 clinical evaluation of PKI-587. ©2011 AACR.

  10. PKI 166 induced redox signalling and apoptosis through activation of p53, MAP kinase and caspase pathway in epidermoid carcinoma.

    Science.gov (United States)

    Das, Subhasis; Dey, Kaushik Kumar; Bharti, Rashmi; MaitiChoudhury, Sujata; Maiti, Sukumar; Mandal, Mahitosh

    2012-01-01

    Cellular redox changes have emerged as a pivotal and proximal event in cancer. PKI 166 is used to determine the effects of redox sensitive inhibition of EGFR, metastasis and apoptosis in epidermoid carcinoma. Cytotoxicity study of PKI 166 (IC50 1.0 microM) treated A431 cells were performed by MTT assay for 48 and 72 hrs. Morphological analysis of PKI 166 treated A431 cells for 48 hrs. revealed the cell shrinkage, loss of filopodia and lamellipodia by phase contrast and SEM images in dose dependent manner. It has cytotoxic effects through inhibiting cellular proliferation, leads to the induction of apoptosis, as increased fraction of sub-G1 phase of the cell cycle, chromatin condensation and DNA ladder. It inhibited cyclin-D1 and cyclin-E expression and induced p53, p21 expression in dose dependent manner. Consequently, an imbalance of Bax/Bcl-2 ratio triggered caspase cascade and subsequent cleavage of PARP, thereby shifting the balance in favour of apoptosis. PKI 166 treatment actively stimulated reactive oxygen species (ROS) and mitochondrial membrane depolarization. It inhibited some metastatic properties of A431 cells supressing colony formation by soft agar assay and inhibition of MMP 9 activity by gelatin zymography and western blot analysis. PKI 166 inhibited growth factor induced phosphorylation of EGFR, Akt, MAPK, JNK and colony formation in A431 cells. Thus the inhibition of proliferation was associated with redox regulation of the caspase cascade, EGFR, Akt/PI3K, MAPK/ ERK and JNK pathway. On the other hand, increased antioxidant activity leads to decreased ROS generation inhibit the anti-proliferative and apoptotic properties of PKI 166 in A431 cells. These observations indicated PKI 166 induced redox signalling dependent inhibition of cell proliferation, metastatic properties and induction of apoptotic potential in epidermoid carcinoma.

  11. The proliferation marker pKi-67 organizes the nucleolus during the cell cycle depending on Ran and cyclin B.

    Science.gov (United States)

    Schmidt, Mirko H H; Broll, Rainer; Bruch, Hans-Peter; Bögler, Oliver; Duchrow, Michael

    2003-01-01

    The proliferation marker pKi-67 ('Ki-67 antigen') is commonly used in clinical and research pathology to detect proliferating cells, as it is only expressed during cell-cycle progression. Despite the fact that this antigen has been known for nearly two decades, there is still no adequate understanding of its function. This study has therefore identified proteins that interact with pKi-67, using a yeast two-hybrid system. A mammalian two-hybrid system and immunoprecipitation studies were used to verify these interactions. Among other cell-cycle regulatory proteins, two binding partners associated with the small GTPase Ran were identified. In addition, DNA-structural and nucleolus-associated proteins binding to pKi-67 were found. Moreover, it was demonstrated that the N-terminal domain of pKi-67 is capable of self-binding to its own repeat region encoded by exon 13. Since RanBP, a protein involved in the transport of macromolecules over the nuclear lamina, was found to be a binding partner, a possible effect of pKi-67 on the localization of cell-cycle regulatory proteins was proposed. To test this hypothesis, a tetracycline-responsive gene expression system was used to induce the pKi-67 fragments previously used for the two-hybrid screens in HeLa cells. Subsequent immunostaining revealed the translocation of cyclin B1 from cytoplasm to nucleoli in response to this expression. It is suggested that pKi-67 is a Ran-associated protein with a role in the disintegration and reformation of the nucleolus and thereby in entry into and exit from the M-phase. Copyright 2002 John Wiley & Sons, Ltd.

  12. DESY: QCD workshop

    International Nuclear Information System (INIS)

    Ingelman, Gunnar

    1994-01-01

    The traditional annual DESY Theory Workshop highlights a topical theory sector. The most recent was under the motto 'Quantum Chromo-Dynamics' - QCD, the field theory of quarks and gluons. The organizers had arranged a programme covering most aspects of current QCD research. This time the workshop was followed by a topical meeting on 'QCD at HERA' to look at the electron-proton scattering experiments now in operation at DESY's new HERA collider

  13. Proceedings of the Japan-USA Collaborative Workshops on the History of Particle Theory in Japan, 1935-1960

    CERN Document Server

    Kawabe, Rokuo; Konuma, Michiji; Elementary particle theory in Japan, 1935-1960 : Japan-USA collaboration, second phase

    1988-01-01

    This volume consists mainly of papers presented at five "workshop", each of two or three days duration, held at various locations in Japan and the United States during 1984-5 by a USA-Japan collaboration for the study of the history of particle physics in Japan, together with some of the discussions and additional interviews.

  14. Influence of Motivation Theory and Supplemental Workshops on First-Time Passing Rates of HBCU Teacher Candidates

    Science.gov (United States)

    Moffett, Noran L.; Frizzell, Melanie M.; Brownlee-Williams, Yolanda; Thompson, Jill M.

    2014-01-01

    The action research methodology for this study reports descriptive statistical findings from the performance of 19 Early Childhood Education African American teacher candidates matriculating through a state-approved program at an HBCU. Researcher-moderators provided a treatment plan of focused summer workshops, conceptualized based upon the…

  15. Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values.

    Science.gov (United States)

    Meltzer, H Y; Matsubara, S; Lee, J C

    1989-10-01

    The pKi values of 13 reference typical and 7 reference atypical antipsychotic drugs (APDs) for rat striatal dopamine D-1 and D-2 receptor binding sites and cortical serotonin (5-HT2) receptor binding sites were determined. The atypical antipsychotics had significantly lower pKi values for the D-2 but not 5-HT2 binding sites. There was a trend for a lower pKi value for the D-1 binding site for the atypical APD. The 5-HT2 and D-1 pKi values were correlated for the typical APD whereas the 5-HT2 and D-2 pKi values were correlated for the atypical APD. A stepwise discriminant function analysis to determine the independent contribution of each pKi value for a given binding site to the classification as a typical or atypical APD entered the D-2 pKi value first, followed by the 5-HT2 pKi value. The D-1 pKi value was not entered. A discriminant function analysis correctly classified 19 of 20 of these compounds plus 14 of 17 additional test compounds as typical or atypical APD for an overall correct classification rate of 89.2%. The major contributors to the discriminant function were the D-2 and 5-HT2 pKi values. A cluster analysis based only on the 5-HT2/D2 ratio grouped 15 of 17 atypical + one typical APD in one cluster and 19 of 20 typical + two atypical APDs in a second cluster, for an overall correct classification rate of 91.9%. When the stepwise discriminant function was repeated for all 37 compounds, only the D-2 and 5-HT2 pKi values were entered into the discriminant function.(ABSTRACT TRUNCATED AT 250 WORDS)

  16. Suppression of Zika Virus Infection and Replication in Endothelial Cells and Astrocytes by PKA Inhibitor PKI 14-22.

    Science.gov (United States)

    Cheng, Fan; Ramos da Silva, Suzane; Huang, I-Chueh; Jung, Jae U; Gao, Shou-Jiang

    2018-02-15

    The recent outbreak of Zika virus (ZIKV), a reemerging flavivirus, and its associated neurological disorders, such as Guillain-Barré (GB) syndrome and microcephaly, have generated an urgent need to develop effective ZIKV vaccines and therapeutic agents. Here, we used human endothelial cells and astrocytes, both of which represent key cell types for ZIKV infection, to identify potential inhibitors of ZIKV replication. Because several pathways, including the AMP-activated protein kinase (AMPK), protein kinase A (PKA), and mitogen-activated protein kinase (MAPK) signaling pathways, have been reported to play important roles in flavivirus replication, we tested inhibitors and agonists of these pathways for their effects on ZIKV replication. We identified the PKA inhibitor PKI 14-22 (PKI) to be a potent inhibitor of ZIKV replication. PKI effectively suppressed the replication of ZIKV from both the African and Asian/American lineages with a high efficiency and minimal cytotoxicity. While ZIKV infection does not induce PKA activation, endogenous PKA activity is essential for supporting ZIKV replication. Interestingly, in addition to PKA, PKI also inhibited another unknown target(s) to block ZIKV replication. PKI inhibited ZIKV replication at the postentry stage by preferentially affecting negative-sense RNA synthesis as well as viral protein translation. Together, these results have identified a potential inhibitor of ZIKV replication which could be further explored for future therapeutic application. IMPORTANCE There is an urgent need to develop effective vaccines and therapeutic agents against Zika virus (ZIKV) infection, a reemerging flavivirus associated with neurological disorders, including Guillain-Barré (GB) syndrome and microcephaly. By screening for inhibitors of several cellular pathways, we have identified the PKA inhibitor PKI 14-22 (PKI) to be a potent inhibitor of ZIKV replication. We show that PKI effectively suppresses the replication of all ZIKV

  17. Two worlds, one smart card : An integrated solution for physical access and logical security using PKI on a single smart card

    NARCIS (Netherlands)

    Hoepman, J.H.; Kleinhuis, G.

    2007-01-01

    We present a use case of the introduction of a large scale Public Key Infrastructure (PKI) environment in an incumbent telecommunications company in The Netherlands. The main characteristics of the case are the integration of an existing physical access facility with a PKI environment for logical

  18. NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1.

    Science.gov (United States)

    Güttler, Thomas; Madl, Tobias; Neumann, Piotr; Deichsel, Danilo; Corsini, Lorenzo; Monecke, Thomas; Ficner, Ralf; Sattler, Michael; Görlich, Dirk

    2010-11-01

    Classic nuclear export signals (NESs) confer CRM1-dependent nuclear export. Here we present crystal structures of the RanGTP-CRM1 complex alone and bound to the prototypic PKI or HIV-1 Rev NESs. These NESs differ markedly in the spacing of their key hydrophobic (Φ) residues, yet CRM1 recognizes them with the same rigid set of five Φ pockets. The different Φ spacings are compensated for by different conformations of the bound NESs: in the case of PKI, an α-helical conformation, and in the case of Rev, an extended conformation with a critical proline docking into a Φ pocket. NMR analyses of CRM1-bound and CRM1-free PKI NES suggest that CRM1 selects NES conformers that pre-exist in solution. Our data lead to a new structure-based NES consensus, and explain why NESs differ in their affinities for CRM1 and why supraphysiological NESs bind the exportin so tightly.

  19. Cytotoxic effect of the Her-2/Her-1 inhibitor PKI-166 on renal cancer cells expressing the connexin 32 gene.

    Science.gov (United States)

    Fujimoto, Eriko; Yano, Tomohiro; Sato, Hiromi; Hagiwara, Kiyokazu; Yamasaki, Hiroshi; Shirai, Sumiko; Fukumoto, Keiko; Hagiwara, Hiromi; Negishi, Etsuko; Ueno, Koichi

    2005-02-01

    We have reported that connexin (Cx) 32 acts as a tumor suppressor gene in renal cancer cells partly due to Her-2 inactivation. Here, we determined if a Her-2/Her-1 inhibitor (PKI-166) can enhance the tumor-suppressive effect of Cx32 in Caki-2 cells from human renal cell carcinoma. The expression of Cx32 in Caki-2 cells was required for PKI-166-induced cytotoxic effect at lower doses. The cyctotoxicity was dependent on the occurrence of apoptosis and partly mediated by Cx32-driven gap junction intercellular communications. These results suggest that PKI-166 further supports the tumor-suppressive effect of the Cx32 gene in renal cancer cells through the induction of apoptosis.

  20. The proliferation marker pKi-67 becomes masked to MIB-1 staining after expression of its tandem repeats.

    Science.gov (United States)

    Schmidt, Mirko H H; Broll, Rainer; Bruch, Hans-Peter; Duchrow, Michael

    2002-11-01

    The Ki-67 antigen, pKi-67, is one of the most commonly used markers of proliferating cells. The protein can only be detected in dividing cells (G(1)-, S-, G(2)-, and M-phase) but not in quiescent cells (G(0)). The standard antibody to detect pKi-67 is MIB-1, which detects the so-called 'Ki-67 motif' FKELF in 9 of the protein's 16 tandem repeats. To investigate the function of these repeats we expressed three of them in an inducible gene expression system in HeLa cells. Surprisingly, addition of a nuclear localization sequence led to a complete absence of signal in the nuclei of MIB-1-stained cells. At the same time antibodies directed against different epitopes of pKi-67 did not fail to detect the protein. We conclude that the overexpression of the 'Ki-67 motif', which is present in the repeats, can lead to inability of MIB-1 to detect its antigen as demonstrated in adenocarcinoma tissue samples. Thereafter, in order to prevent the underestimation of Ki-67 proliferation indices in MIB-1-labeled preparations, additional antibodies (for example, MIB-21) should be used. Additionally, we could show in a mammalian two-hybrid assay that recombinant pKi-67 repeats are capable of self-associating with endogenous pKi-67. Speculating that the tandem repeats are intimately involved in its protein-protein interactions, this offers new insights in how access to these repeats is regulated by pKi-67 itself.

  1. Antitumor efficacy profile of PKI-402, a dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor.

    Science.gov (United States)

    Mallon, Robert; Hollander, Irwin; Feldberg, Larry; Lucas, Judy; Soloveva, Veronica; Venkatesan, Aranapakam; Dehnhardt, Christoph; Delos Santos, Efren; Chen, Zecheng; Dos Santos, Osvaldo; Ayral-Kaloustian, Semiramis; Gibbons, Jay

    2010-04-01

    PKI-402 is a selective, reversible, ATP-competitive, equipotent inhibitor of class I phosphatidylinositol 3-kinases (PI3K), including PI3K-alpha mutants, and mammalian target of rapamycin (mTOR; IC(50) versus PI3K-alpha = 2 nmol/L). PKI-402 inhibited growth of human tumor cell lines derived from breast, brain (glioma), pancreas, and non-small cell lung cancer tissue and suppressed phosphorylation of PI3K and mTOR effector proteins (e.g., Akt at T308) at concentrations that matched those that inhibited cell growth. In MDA-MB-361 [breast: Her2(+) and PIK3CA mutant (E545K)], 30 nmol/L PKI-402 induced cleaved poly(ADP-ribose) polymerase (PARP), a marker for apoptosis. In vivo, PKI-402 inhibited tumor growth in MDA-MB-361, glioma (U87MG), and lung (A549) xenograft models. In MDA-MB-361, PKI-402 at 100 mg/kg (daily for 5 days, one round) reduced initial tumor volume of 260 mm(3) to 129 mm(3) and prevented tumor regrowth for 70 days. In MDA-MB-361 tumors, PKI-402 (100 mg/kg, single dose) suppressed Akt phosphorylation (at T308) and induced cleaved PARP. Suppression of phosphorylated Akt (p-Akt) was complete at 8 hours and still evident at 24 hours. Cleaved PARP was evident at 8 and 24 hours. In normal tissue (heart and lung), PKI-402 (100 mg/kg) had minimal effect on p-Akt, with no detectable cleaved PARP. Preferential accumulation of PKI-402 in tumor tissue was observed. Complete, sustained suppression of Akt phosphorylation may cause tumor regression in MDA-MB-361 and other xenograft models. We are testing whether dual PI3K/mTOR inhibitors can durably suppress p-Akt, induce cleaved PARP, and cause tumor regression in a diverse set of human tumor xenograft models. Mol Cancer Ther; 9(4); 976-84. (c)2010 AACR.

  2. Design and implementation of a secure workflow system based on PKI/PMI

    Science.gov (United States)

    Yan, Kai; Jiang, Chao-hui

    2013-03-01

    As the traditional workflow system in privilege management has the following weaknesses: low privilege management efficiency, overburdened for administrator, lack of trust authority etc. A secure workflow model based on PKI/PMI is proposed after studying security requirements of the workflow systems in-depth. This model can achieve static and dynamic authorization after verifying user's ID through PKC and validating user's privilege information by using AC in workflow system. Practice shows that this system can meet the security requirements of WfMS. Moreover, it can not only improve system security, but also ensures integrity, confidentiality, availability and non-repudiation of the data in the system.

  3. Modelling of P-waves velocity function from the PKiKP and PKIKP phases; Modelizacion de la funcion velocidad para las ondas P a partir de las fases PKiKP y PKIKP

    Energy Technology Data Exchange (ETDEWEB)

    Ramirez-Nicolas, M.

    2011-07-01

    The structure of the Earth is characterized by a number of regions which have different physical properties. For their study one uses models such PREM or IASPEI91. These models describe the internal structure of the Earth providing us the theoretical values of the velocity of the waves that pass through each of these regions. In this paper we focus on the waves that cross the inner core (PKIKP), and the reflected waves on the surface of the inner core (PKiKP). The aim of this study is to identify the PKiKP and PKIKP phases in a seismogram and compare them with the theoretical values obtained from the models. Another objective of this work is to propose an expression for the propagation velocity of seismic waves at the discontinuity between the outer and inner core from the minimization of waste of time (time difference between the arrival of the wave PKIKP and PKiKP). For this study we have selected two earthquakes, one occurred in Colombia, 04/26/1999 (Mw 5.9) and the other in Peru-Ecuador 16/11/2007 (Mw = 6.8). We have analyzed only the seismograms from stations with epicentral distances between 130 degree centigrade and 140 degree centigrade, because of the interference phenomena between the PKIKP and the PKiKP for epicentral distances less than 130 degree centigrade. (Author) 14 refs.

  4. pKI values of prazosin and idazoxan for receptors stimulated by neuronally released transmitter in the epididymal portion of rat isolated vas deferens.

    Science.gov (United States)

    Mackay, D; Kengatharan, M

    1994-01-01

    1. A new method has been used to measure pKI values of prazosin and idazoxan against neuronally-released transmitter in the epididymal portion of the rat isolated vas deferens. The most reproducible results were obtained with a prolonged antagonist equilibration time (1 h). 2. Under these conditions the pKI of prazosin was practically unaffected by addition of alpha, beta-methylene-adenosine-5'-triphosphate (10 microM) to desensitize purinoceptors. Addition of desmethylimipramine (DMI) (0.3 microM) produced a small, but statistically non-significant, reduction. 3. The same method has been used to measure the pKI of prazosin against exogenous noradrenaline. In the latter case addition of DMI (0.3 microM) and corticosterone (30 microM) together produced a statistically significant reduction in the apparent pKI of prazosin. 4. The new method for estimating pKI values shows that DMI itself acts either pseudo-irreversibly or non-competitively and may be reducing the apparent pKI of prazosin. 5. The pKI values obtained for prazosin and idazoxan against neuronally-released transmitter are in good agreement with those obtained by other workers for the actions of these drugs on alpha-adrenoceptors.

  5. The pkI gene encoding pyruvate kinase I links to the luxZ gene which enhances bioluminescence of the lux operon from Photobacterium leiognathi.

    Science.gov (United States)

    Lin, J W; Lu, H C; Chen, H Y; Weng, S F

    1997-10-09

    Partial 3'-end nucleotide sequence of the pkI gene (GenBank accession No. AF019143) from Photobacterium leiognathi ATCC 25521 has been determined, and the encoded pyruvate kinase I is deduced. Pyruvate kinase I is the key enzyme of glycolysis, which converts phosphoenol pyruvate to pyruvate. Alignment and comparison of pyruvate kinase Is from P. leiognathi, E. coli and Salmonella typhimurium show that they are homologous. Nucleotide sequence reveals that the pkI gene is linked to the luxZ gene that enhances bioluminescence of the lux operon from P. leiognathi. The gene order of the pkI and luxZ genes is-pk1-ter-->-R&R"-luxZ-ter"-->, whereas ter is transcriptional terminator for the pkI and related genes, and R&R" is the regulatory region and ter" is transcriptional terminator for the luxZ gene. It clearly elicits that the pkI gene and luxZ gene are divided to two operons. Functional analysis confirms that the potential hairpin loop omega T is the transcriptional terminator for the pkI and related genes. It infers that the pkI and related genes are simply linked to the luxZ gene in P. leiognathi genome.

  6. High-level mRNA quantification of proliferation marker pKi-67 is correlated with favorable prognosis in colorectal carcinoma.

    Science.gov (United States)

    Ihmann, Thomas; Liu, Jian; Schwabe, Wolfgang; Häusler, Peter; Behnke, Detlev; Bruch, Hans-Peter; Broll, Rainer; Windhövel, Ute; Duchrow, Michael

    2004-12-01

    The present study retrospectively examines the expression of pKi-67 mRNA and protein in colorectal carcinoma and their correlation to the outcome of patients. Immunohistochemistry and quantitative RT-PCR were used to analyze the expression of pKi-67 in 43 archival specimens of patients with curatively resected primary colorectal carcinoma, who were not treated with neo-adjuvant therapy. We determined a median pKi-67 (MIB-1) labeling index of 31.3% (range 10.3-66.4%), and a mean mRNA level of 0.1769 (DeltaC(T): range 0.01-0.69); indices and levels did not correlate. High pKi-67 mRNA DeltaC(T) values were associated with a significantly favorable prognosis, while pKi-67 labeling indices were not correlated to prognostic outcome. A multivariate analysis of clinical and biological factors indicated that tumor stage (UICC) and pKi-67 mRNA expression level were independent prognostic factors. Quantitatively determined pKi-67 mRNA can be a good and new prognostic indicator for primary resected colorectal carcinoma.

  7. Role of regulatory subunits and protein kinase inhibitor (PKI) in determining nuclear localization and activity of the catalytic subunit of protein kinase A.

    Science.gov (United States)

    Wiley, J C; Wailes, L A; Idzerda, R L; McKnight, G S

    1999-03-05

    Regulation of protein kinase A by subcellular localization may be critical to target catalytic subunits to specific substrates. We employed epitope-tagged catalytic subunit to correlate subcellular localization and gene-inducing activity in the presence of regulatory subunit or protein kinase inhibitor (PKI). Transiently expressed catalytic subunit distributed throughout the cell and induced gene expression. Co-expression of regulatory subunit or PKI blocked gene induction and prevented nuclear accumulation. A mutant PKI lacking the nuclear export signal blocked gene induction but not nuclear accumulation, demonstrating that nuclear export is not essential to inhibit gene induction. When the catalytic subunit was targeted to the nucleus with a nuclear localization signal, it was not sequestered in the cytoplasm by regulatory subunit, although its activity was completely inhibited. PKI redistributed the nuclear catalytic subunit to the cytoplasm and blocked gene induction, demonstrating that the nuclear export signal of PKI can override a strong nuclear localization signal. With increasing PKI, the export process appeared to saturate, resulting in the return of catalytic subunit to the nucleus. These results demonstrate that both the regulatory subunit and PKI are able to completely inhibit the gene-inducing activity of the catalytic subunit even when the catalytic subunit is forced to concentrate in the nuclear compartment.

  8. Modeling of frequency agile devices: development of PKI neuromodeling library based on hierarchical network structure

    Science.gov (United States)

    Sanchez, P.; Hinojosa, J.; Ruiz, R.

    2005-06-01

    Recently, neuromodeling methods of microwave devices have been developed. These methods are suitable for the model generation of novel devices. They allow fast and accurate simulations and optimizations. However, the development of libraries makes these methods to be a formidable task, since they require massive input-output data provided by an electromagnetic simulator or measurements and repeated artificial neural network (ANN) training. This paper presents a strategy reducing the cost of library development with the advantages of the neuromodeling methods: high accuracy, large range of geometrical and material parameters and reduced CPU time. The library models are developed from a set of base prior knowledge input (PKI) models, which take into account the characteristics common to all the models in the library, and high-level ANNs which give the library model outputs from base PKI models. This technique is illustrated for a microwave multiconductor tunable phase shifter using anisotropic substrates. Closed-form relationships have been developed and are presented in this paper. The results show good agreement with the expected ones.

  9. PKI-587 and sorafenib targeting PI3K/AKT/mTOR and Ras/Raf/MAPK pathways synergistically inhibit HCC cell proliferation.

    Science.gov (United States)

    Gedaly, Roberto; Angulo, Paul; Hundley, Jonathan; Daily, Michael F; Chen, Changguo; Evers, B Mark

    2012-08-01

    Deregulated Ras/Raf/MAPK and PI3K/AKT/mTOR signaling pathways are found in hepatocellular carcinoma (HCC). This study aimed to test the inhibitory effects of PKI-587 and sorafenib as single agents or in combination on HCC (Huh7 cell line) proliferation. (3)H-thymidine incorporation and MTT assay were used to assess Huh7 cell proliferation. Phosphorylation of the key enzymes in the Ras/Raf/MAPK and PI3K/AKT/mTOR pathways was detected by Western blot. We found that PKI-587 is a more potent PI3K/mTOR inhibitor than PI-103. Combination of PKI-587 and sorafenib was a more effective inhibitor of Huh7 proliferation than the combination of PI-103 and sorafenib. Combination of PKI-587 and sorafenib synergistically inhibited epidermal growth factor (EGF)-stimulated Huh7 proliferation compared with monodrug therapy. EGF increased phosphorylation of Ras/Raf downstream signaling proteins MEK and ERK; EGF-stimulated activation was inhibited by sorafenib. However, sorafenib, as a single agent, increased AKT (Ser473) phosphorylation. EGF-stimulated AKT (ser473) activation was inhibited by PKI-587. PKI-587 is a potent inhibitor of AKT (Ser473), mTOR (Ser2448), and S6K (Thr389) phosphorylation; in contrast, rapamycin stimulated mTOR complex 2 substrate AKT(Ser473) phosphorylation although it inhibited mTOR complex 1 substrate S6K phosphorylation. PKI-587, as a single agent, stimulated MEK and ERK phosphorylation. However, when PKI-587 and sorafenib were used in combination, they inhibited all the tested kinases in the Ras/Raf /MAPK and PI3K/AKT/mTOR pathways. The combination of PKI-587 and sorafenib has the advantage over monodrug therapy on inhibition of HCC cell proliferation by blocking both PI3K/AKT/mTOR and Ras/Raf/MAPK signaling pathways. Copyright © 2012 Elsevier Inc. All rights reserved.

  10. FOREWORD: Proceedings of the Second Workshop on Theory meets Industry (Erwin-Schrödinger-Institute (ESI), Vienna, Austria, 12 14 June 2007)

    Science.gov (United States)

    Hafner, Jürgen

    2008-02-01

    The development of modern materials science has led to a growing need to understand the phenomena determining the properties of materials on an atomistic level. As the behavior of atoms and electrons is governed by the laws of quantum mechanics, accurate and efficient techniques for solving the basic quantum-mechanical equations for very complex many-atom, many-electron systems are required. The development of density-functional theory (DFT) represents a decisive step forwards in our efforts to develop tools for ab initio atomistic simulations of complex materials, preparing the way towards computational materials design. The development of these ab initio simulation methods, whose aim is to model processes in materials by solving the coupled Newtonian equations of motion of the atoms and the Schrödinger equation for the electrons from first principles without any other input than the atomic numbers of the constituents, is part of fundamental research. Hence, for a long time the development and application of DFT methods has been a domain of academic research. Only during the past decade, based on the development of increasingly sophisticated codes and better computer performance, has the impact of DFT-based simulation methods has spread from academia to industry. New opportunities are opening for innovative materials research across physics, chemistry, surface science and nanotechnology extending even to earth sciences and molecular biology. In 1998 we organized, at the Vienna University of Technology, a first workshop entitled 'Electronic Structure Calculations for Industry and Basic Sciences' (short title 'Theory meets Industry') to celebrate the start of the European Science Foundation (ESF) research program 'Electronic Structure Calculations for Elucidating the Complex Atomistic Behavior of Solids and Surfaces', known as the Ψk-network. At this workshop, researchers from academia presented recent results in the development of ab initio simulation methods and

  11. Proceedings of the Second Workshop on Theory meets Industry (Erwin-Schrödinger-Institute (ESI), Vienna, Austria, 12-14 June 2007).

    Science.gov (United States)

    Hafner, Jürgen

    2008-02-13

    The development of modern materials science has led to a growing need to understand the phenomena determining the properties of materials on an atomistic level. As the behavior of atoms and electrons is governed by the laws of quantum mechanics, accurate and efficient techniques for solving the basic quantum-mechanical equations for very complex many-atom, many-electron systems are required. The development of density-functional theory (DFT) represents a decisive step forwards in our efforts to develop tools for ab initio atomistic simulations of complex materials, preparing the way towards computational materials design. The development of these ab initio simulation methods, whose aim is to model processes in materials by solving the coupled Newtonian equations of motion of the atoms and the Schrödinger equation for the electrons from first principles without any other input than the atomic numbers of the constituents, is part of fundamental research. Hence, for a long time the development and application of DFT methods has been a domain of academic research. Only during the past decade, based on the development of increasingly sophisticated codes and better computer performance, has the impact of DFT-based simulation methods has spread from academia to industry. New opportunities are opening for innovative materials research across physics, chemistry, surface science and nanotechnology extending even to earth sciences and molecular biology. In 1998 we organized, at the Vienna University of Technology, a first workshop entitled 'Electronic Structure Calculations for Industry and Basic Sciences' (short title 'Theory meets Industry') to celebrate the start of the European Science Foundation (ESF) research program 'Electronic Structure Calculations for Elucidating the Complex Atomistic Behavior of Solids and Surfaces', known as the Ψ(k)-network. At this workshop, researchers from academia presented recent results in the development of ab initio simulation methods

  12. Higher Education Partners with the Federal Government for PKI: Both Communities Bring Substantial Expertise and Investment to the Solutions.

    Science.gov (United States)

    PKI for Networked Higher Education Working Group.

    2000-01-01

    One barrier to Web-based education is lack of an effective system to identify and authorize involved participants, content, and institutions. PKI (public-key infrastructure) is an emerging technology that can certify the correct identity of each person and communication in Web-based learning. A June 2000 National Science Foundation workshop…

  13. Endogenous PKI gamma limits the duration of the anti-apoptotic effects of PTH and beta-adrenergic agonists in osteoblasts.

    Science.gov (United States)

    Chen, Xin; Song, In-Hwan; Dennis, James E; Greenfield, Edward M

    2007-05-01

    PKI gamma knockdown substantially extended the anti-apoptotic effects of PTH and beta-adrenergic agonists, whereas PKI gamma overexpression decreased these effects. Therefore, inhibition of PKI gamma activity may provide a useful co-therapy in combination with intermittent PTH or beta-adrenergic agonists for bone loss in conditions such as osteoporosis. PTH has both catabolic and anabolic effects on bone, which are primarily caused by cAMP/protein kinase A (PKA) signaling and regulation of gene expression. We previously showed that protein kinase inhibitor-gamma (PKI gamma) is required for efficient termination of cAMP/PKA signaling and gene expression after stimulation with PTH or beta-adrenergic agonists. Inhibition of osteoblast apoptosis is thought to be an important, but transient, mechanism partly responsible for the anabolic effects of intermittent PTH. Therefore, we hypothesized that endogenous PKI gamma also terminates the anti-apoptotic effect of PTH. PKI gamma knockdown by antisense transfection or siRNA was used to examine the ability of endogenous PKI gamma to modulate the anti-apoptotic effects of PTH and beta-adrenergic agonists in ROS 17/2.8 cells. Knockdown of PKI gamma substantially extended the anti-apoptotic effects of PTH, whether apoptosis was induced by etoposide or dexamethasone. In contrast, overexpression of PKI gamma decreased the anti-apoptotic effect of PTH pretreatment. This study is also the first demonstration that beta-adrenergic agonists mimic the anti-apoptotic effects of PTH in osteoblasts. Moreover, PKI gamma knockdown also substantially extended this anti-apoptotic effect of beta-adrenergic agonists. Taken together, these results show that endogenous PKI gamma limits the duration of the anti-apoptotic effects of cAMP/PKA signaling in osteoblasts. Because significant individual variability exists in the anabolic responses to PTH therapy in current clinical treatment of osteoporosis, inhibition of PKI gamma activity may provide a

  14. PREFACE: Selected contributions from the 3rd Theory Meets Industry International Workshop, TMI2009 (Nagoya, Japan, 11-13 November 2009) Selected contributions from the 3rd Theory Meets Industry International Workshop, TMI2009 (Nagoya, Japan, 11-13 November 2009)

    Science.gov (United States)

    Tanaka, Isao; Hafner, Jürgen; Wimmer, Erich; Asahi, Ryoji

    2010-09-01

    The structures, physicochemical and thermodynamic properties of materials are becoming increasingly amenable to treatment by first-principles (ab initio) quantum mechanical simulations. Calculations containing a few hundred atoms are now routine, thanks to improvements in computer technology and computational techniques. Schemes to determine electronic structures more accurately and to treat more complex systems continue to be developed. A growing number of scientists and engineers are becoming aware of the power of these approaches. By applying these new computational tools, materials science and technology is expected to enter a new era of accelerated progress and efficiency. In 1998 the first workshop entitled 'Theory Meets Industry' (TMI) was held at the Vienna University of Technology. The aim of the workshop was to direct the potential of the ab initio simulation codes developed in academia towards the necessities arising from industrial research. Over the next decade, significant advances in ab initio methodology and its application to academic and industrial research were achieved. It was thus considered timely to hold a second TMI workshop in 2007, again in Vienna. The contributions from academia concentrated on a wide range of new developments in ab initio simulations, as well as on applications at the forefront of materials research. Speakers from the industrial sector also emphasized the progress made in successfully applying ab initiotechniques to key areas of modern technology. The proceedings were published in Journal of Physics: Condensed Matter as a special issue (volume 20, number 6, 2008), which was included in the 'Top papers 2008 showcase' of that journal. Following the notable success of the first two workshops, it was decided that the third TMI workshop would be held outside Europe. Holding the workshop in Japan was intended to increase awareness of theoretical materials science and foster further international collaboration in this field

  15. Inhibition of mTOR's Catalytic Site by PKI-587 Is a Promising Therapeutic Option for Gastroenteropancreatic Neuroendocrine Tumor Disease.

    Science.gov (United States)

    Freitag, Helma; Christen, Friederike; Lewens, Florentine; Grass, Irina; Briest, Franziska; Iwaszkiewicz, Sara; Siegmund, Britta; Grabowski, Patricia

    2017-01-01

    The characteristic clinical heterogeneity and mostly slow-growing behavior of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) cause problems in finding appropriate treatments. Thus, the current therapy options are not satisfactory. PKI-587 is a highly potent, novel dual inhibitor of PI3K and mTORC1/C2. We assessed the effects of PKI-587 in different GEP-NEN tumor models, including the poorly differentiated cell line LCC-18, and compared them with those of the established mTORC1 inhibitor everolimus. We treated BON, QGP-1, KRJ-I, and LCC-18 cell lines with increasing concentrations of the inhibitor PKI-587, and compared the results with those of everolimus and DMSO. We assessed the impact of the treatments on viability (WST-1 assay), on apoptotic processes (caspase 3/7 assay, JC-1), and on cell cycle regulation (flow cytometry). We determined alterations in signaling mediators by phosphor-specific Western blot analysis and conducted multiplexed gene expression analysis (nCounter® technology). In all cell lines, PKI-587 dose-dependently inhibited proliferation, whereas everolimus was less effective. Treatment with PKI-587 led to cell cycle arrest and induction of apoptosis and successfully suppressed activity of the direct mTORC1 target 4E-BP1, a crucial factor for tumor genesis only partially inhibited by everolimus. Gene expression analyses revealed relevant changes of RAS, MAPK, STAT, and PI3K pathway genes after treatment. Treatment-dependent and cell line-characteristic effects on AKT/Rb/E2F signaling regarding cell cycle control and apoptosis are extensively discussed in this paper. PI3K/mTOR dual targeting is a promising new therapeutic approach in neuroendocrine tumor disease that should be evaluated in further clinical trials. © 2016 The Author(s) Published by S. Karger AG, Basel.

  16. Workshop report

    African Journals Online (AJOL)

    abp

    2017-09-14

    Sep 14, 2017 ... health: report of first EQUIST training workshop in Nigeria .... The difference between the before and after measurements was ... After the administration of the pre-workshop questionnaire the ... represent Likert rating scale of 1-5 points, where 1point = grossly .... Procedures Manual for the "Evaluating.

  17. INDICO Workshop

    CERN Multimedia

    CERN. Geneva; Fabbrichesi, Marco

    2004-01-01

    The INtegrated DIgital COnferencing EU project has finished building a complete software solution to facilitate the MANAGEMENT OF CONFERENCES, workshops, schools or simple meetings from their announcement to their archival. Everybody involved in the organization of events is welcome to join this workshop, in order to understand the scope of the project and to see demonstrations of the various features.

  18. Proceedings of the Workshop on Applications of Distributed System Theory to the Control of Large Space Structures

    Science.gov (United States)

    Rodriguez, G. (Editor)

    1983-01-01

    Two general themes in the control of large space structures are addressed: control theory for distributed parameter systems and distributed control for systems requiring spatially-distributed multipoint sensing and actuation. Topics include modeling and control, stabilization, and estimation and identification.

  19. Bias-dependent hybrid PKI empirical-neural model of microwave FETs

    Science.gov (United States)

    Marinković, Zlatica; Pronić-Rančić, Olivera; Marković, Vera

    2011-10-01

    Empirical models of microwave transistors based on an equivalent circuit are valid for only one bias point. Bias-dependent analysis requires repeated extractions of the model parameters for each bias point. In order to make model bias-dependent, a new hybrid empirical-neural model of microwave field-effect transistors is proposed in this article. The model is a combination of an equivalent circuit model including noise developed for one bias point and two prior knowledge input artificial neural networks (PKI ANNs) aimed at introducing bias dependency of scattering (S) and noise parameters, respectively. The prior knowledge of the proposed ANNs involves the values of the S- and noise parameters obtained by the empirical model. The proposed hybrid model is valid in the whole range of bias conditions. Moreover, the proposed model provides better accuracy than the empirical model, which is illustrated by an appropriate modelling example of a pseudomorphic high-electron mobility transistor device.

  20. Joint Special Operations University SOF-Power Workshop: A Way Forward for Special Operations Theory and Strategic Art

    Science.gov (United States)

    2011-08-01

    participants‘ particular points of view and may be helpful in researching, developing, testing, and explaining theory. The Secret War in Laos was...Jan 1985. Tse -Tung, Mao. On Guerrilla Warfare. Praeger, New York: 1961. The Use and Utility of Force; Force Fungibles Art, Robert J. and...Penguin Books, New York: 1968. Griffith, Samuel B., (BrigGen (Ret) USMC). On Guerrilla Warfare – Mao Tse -Tung. Praeger, New York: 1961

  1. Workshop Proceedings

    DEFF Research Database (Denmark)

    2012-01-01

    , the main focus there is on spoken languages in their written and spoken forms. This series of workshops, however, offers a forum for researchers focussing on sign languages. For the third time, the workshop had sign language corpora as its main topic. This time, the focus was on the interaction between...... corpus and lexicon. More than half of the papers presented contribute to this topic. Once again, the papers at this workshop clearly identify the potentials of even closer cooperation between sign linguists and sign language engineers, and we think it is events like this that contribute a lot to a better...

  2. Public Key Infrastructure (PKI) Increment 2 Root Cause Analysis (RCA) for Performance Assessments and Root Cause Analyses (PARCA)

    Science.gov (United States)

    2015-05-01

    DoD PKI enables secure encryption , authentication of network transactions, data integrity, and non-repudiation to a broad range of government- and...Identity Verification (PIV) Authentication Certificates.  Implement Rivest, Shamir, and Adelman ( RSA ) 2048 when viable and transition to Secure Hash...facilitate missions through digital signing, encryption , and web-server authentication. However, reliability of the tokens was unacceptable, with

  3. WORKSHOP: Let's twist again..

    Energy Technology Data Exchange (ETDEWEB)

    Villalobos Baillie, Orlando

    1988-12-15

    In the quantum chromodynamics (QCD) candidate theory of interquark forces, calculations involve summing the effects from many different possible quark/gluon interactions. In addition to the 'leading term' frequently used as the basis for QCD calculations, additional contributions — so-called 'higher twists' — are modulated by powers of kinematical factors. An illuminating international workshop to discuss higher twist QCD was held at the College de France, Paris, from 21-23 September.

  4. Workshop meeting

    International Nuclear Information System (INIS)

    Veland, Oeystein

    2004-04-01

    1-2 September 2003 the Halden Project arranged a workshop on 'Innovative Human-System Interfaces and their Evaluation'. This topic is new in the HRP 2003-2005 programme, and it is important to get feedback from member organizations to the work that is being performed in Halden. It is also essential that relevant activities and experiences in this area from the member organizations are shared with the Halden staff and other HRP members. Altogether 25 persons attended the workshop. The workshop had a mixture of presentations and discussions, and was chaired by Dominique Pirus of EDF, France. Day one focused on the HRP/IFE activities on Human-System Interface design, including Function-oriented displays, Ecological Interface Design, Task-oriented displays, as well as work on innovative display solutions for the oil and gas domain. There were also presentations of relevant work in France, Japan and the Czech Republic. The main focus of day two was the verification and validation of human-system interfaces, with presentations of work at HRP on Human-Centered Validation, Criteria-Based System Validation, and Control Room Verification and Validation. The chairman concluded that it was a successful workshop, although one could have had more time for discussions. The Halden Project got valuable feedback and viewpoints on this new topic during the workshop, and will consider all recommendations related to the future work in this area. (Author)

  5. Epidermal growth factor receptor inhibitor PKI-166 governs cardiovascular protection without beneficial effects on the kidney in hypertensive 5/6 nephrectomized rats.

    Science.gov (United States)

    Ulu, Nadir; Mulder, Gemma M; Vavrinec, Peter; Landheer, Sjoerd W; Duman-Dalkilic, Basak; Gurdal, Hakan; Goris, Maaike; Duin, Marry; van Dokkum, Richard P E; Buikema, Hendrik; van Goor, Harry; Henning, Robert H

    2013-06-01

    Transactivation of epidermal growth factor receptor (EGFR) signaling by G protein-coupled receptors has been implicated in several cardiovascular (CV) conditions, including hypertension, heart failure, and cardiac and vascular hypertrophy. However, the therapeutic potential of EGFR inhibition in these conditions is currently unknown. The main objective of the present study was to investigate cardiac, vascular, and renal effects of EGFR inhibition by 4-[4-[[(1R)-1-phenylethyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenol (PKI-166) in the hypertensive chronic kidney disease model. Rats underwent 5/6 nephrectomy (5/6Nx) and were treated with PKI-166, lisinopril or vehicle from week 6 after disease induction until week 12. Sham animals received either PKI-166 or vehicle. Treatment with PKI-166 did not affect the development of the characteristic renal features in 5/6Nx, including proteinuria, diminished creatinine clearance, and increased glomerulosclerosis, whereas these were attenuated by lisinopril. Despite absence of effects on progressive renal damage, PKI-166 attenuated the progression of hypertension and maintained cardiac function (left ventricle end-diastolic pressure) to a similar extent as lisinopril. Also, PKI-166 attenuated the increase in phosphorylated EGFR in the heart as induced by 5/6Nx. Moreover, PKI-166 and lisinopril restored the impaired contraction of isolated thoracic aortic rings to phenylephrine and angiotensin II and impaired myogenic constriction of small mesenteric arteries in 5/6Nx rats. Blockade of the EGFR displays a CV benefit independent of limiting the progression of renal injury. Our findings extend the evidence on EGFR signaling as a target in CV disorders.

  6. Effective intracellular inhibition of the cAMP-dependent protein kinase by microinjection of a modified form of the specific inhibitor peptide PKi in living fibroblasts.

    Science.gov (United States)

    Fernandez, A; Mery, J; Vandromme, M; Basset, M; Cavadore, J C; Lamb, N J

    1991-08-01

    In order to obtain a peptide retaining its biological activity following microinjection into living cells, we have modified a synthetic peptide [PKi(m)(6-24)], derived from the specific inhibitor protein of the cAMP-dependent protein kinase (A-kinase) in two ways: (1) substitution of the arginine at position 18 for a D-arginine; (2) blockade of the side chain on the C-terminal aspartic acid by a cyclohexyl ester group. In an in vitro assay, PKi(m) has retained a specific inhibitory activity against A-kinase as assessed against six other kinases, with similar efficiency to that of the unmodified PKi(5-24) peptide. Microinjection of PKi(m) into living fibroblasts reveals its capacity to prevent the changes in cell morphology and cytoskeleton induced by drugs which activate endogenous A-kinase, whereas the original PKi peptide failed to do so. This inhibition of A-kinase in vivo by PKi(m) lasts between 4 and 6 h after injection. In light of its effective half-life, this modified peptide opens a route for the use of biologically active peptides in vivo, an approach which has been hampered until now by the exceedingly short half-life of peptides inside living cells. By providing a direct means of inhibiting A-kinase activity for sufficiently long periods to observe effects on cellular functions in living cells, PKi(m) represents a powerful tool in studying the potential role of cAMP-dependent phosphorylation in vivo.

  7. Network workshop

    DEFF Research Database (Denmark)

    Bruun, Jesper; Evans, Robert Harry

    2014-01-01

    This paper describes the background for, realisation of and author reflections on a network workshop held at ESERA2013. As a new research area in science education, networks offer a unique opportunity to visualise and find patterns and relationships in complicated social or academic network data....... These include student relations and interactions and epistemic and linguistic networks of words, concepts and actions. Network methodology has already found use in science education research. However, while networks hold the potential for new insights, they have not yet found wide use in the science education...... research community. With this workshop, participants were offered a way into network science based on authentic educational research data. The workshop was constructed as an inquiry lesson with emphasis on user autonomy. Learning activities had participants choose to work with one of two cases of networks...

  8. Dynamic defense workshop :

    Energy Technology Data Exchange (ETDEWEB)

    Crosby, Sean Michael; Doak, Justin E.; Haas, Jason Juedes.; Helinski, Ryan; Lamb, Christopher C.

    2013-02-01

    On September 5th and 6th, 2012, the Dynamic Defense Workshop: From Research to Practice brought together researchers from academia, industry, and Sandia with the goals of increasing collaboration between Sandia National Laboratories and external organizations, de ning and un- derstanding dynamic, or moving target, defense concepts and directions, and gaining a greater understanding of the state of the art for dynamic defense. Through the workshop, we broadened and re ned our de nition and understanding, identi ed new approaches to inherent challenges, and de ned principles of dynamic defense. Half of the workshop was devoted to presentations of current state-of-the-art work. Presentation topics included areas such as the failure of current defenses, threats, techniques, goals of dynamic defense, theory, foundations of dynamic defense, future directions and open research questions related to dynamic defense. The remainder of the workshop was discussion, which was broken down into sessions on de ning challenges, applications to host or mobile environments, applications to enterprise network environments, exploring research and operational taxonomies, and determining how to apply scienti c rigor to and investigating the eld of dynamic defense.

  9. Virtual Workshop

    DEFF Research Database (Denmark)

    Buus, Lillian; Bygholm, Ann

    In relation to the Tutor course in the Mediterranean Virtual University (MVU) project, a virtual workshop “Getting experiences with different synchronous communication media, collaboration, and group work” was held with all partner institutions in January 2006. More than 25 key-tutors within MVU...

  10. A PKA survival pathway inhibited by DPT-PKI, a new specific cell permeable PKA inhibitor, is induced by T. annulata in parasitized B-lymphocytes.

    Science.gov (United States)

    Guergnon, Julien; Dessauge, Frederic; Traincard, François; Cayla, Xavier; Rebollo, Angelita; Bost, Pierre Etienne; Langsley, Gordon; Garcia, Alphonse

    2006-08-01

    T. annulata, an intracellular pathogenic parasite of the Aplicomplexa protozoan family infects bovine B-lymphocytes and macrophages. Parasitized cells that become transformed survive and proliferate independently of exogenous growth factors. In the present study, we used the isogenic non parasitized BL3 and parasitized TBL3 B cell lines, as a model to evaluate the contribution of two-major PI3-K- and PKA-dependent anti-apoptotic pathways in the survival of T. annulata parasitized B lymphocytes. We found that T. annulata increases PKA activity, induces over-expression of the catalytic subunit and down-regulates the pro-survival phosphorylation state of Akt/PKB. Consistent with a role of PKA activation in survival, two pharmacological inhibitors H89 and KT5720 ablate PKA-dependent survival of parasitized cells. To specifically inhibit PKA pro-survival pathways we linked the DPTsh1 peptide shuttle sequence to PKI(5-24) and we generated DPT-PKI, a cell permeable PKI. DPT-PKI specifically inhibited PKA activity in bovine cell extracts and, as expected, also inhibited the PKA-dependent survival of T. annulata parasitized TBL3 cells. Thus, parasite-dependent constitutive activation of PKA in TBL3 cells generates an anti-apoptotic pathway that can protect T. annulata-infected B cells from apoptosis. These results also indicate that DPT-PKI could be a powerful tool to inhibit PKA pathways in other cell types.

  11. In vivo dynamics and kinetics of pKi-67: transition from a mobile to an immobile form at the onset of anaphase.

    Science.gov (United States)

    Saiwaki, Takuya; Kotera, Ippei; Sasaki, Mitsuho; Takagi, Masatoshi; Yoneda, Yoshihiro

    2005-08-01

    A cell proliferation marker protein, pKi-67, distributes to the chromosome periphery during mitosis and nucleolar heterochromatin in the interphase. We report here on the structural domains of pKi-67 that are required for its correct distribution. While both the LR domain and the conserved domain were involved in localization to the nucleolar heterochromatin, both the LR domain and the Ki-67 repeat domain were required for its distribution to the mitotic chromosome periphery. Using in vivo time-lapse microscopy, GFP-pKi-67 was dynamically tracked from the mitotic chromosome periphery to reforming nucleoli via prenucleolar bodies (PNBs). The signals in PNBs then moved towards and fused into the reforming nucleoli with a thin string-like fluorescence during early G1 phase. An analysis of the in vivo kinetics of pKi-67 using photobleaching indicated that the association of pKi-67 with chromatin was progressively altered from "loose" to "tight" after the onset of anaphase. These findings indicate that pKi-67 dynamically alters the nature of the interaction with chromatin structure during the cell cycle, which is closely related to the reformation process of the interphase nucleolar chromatin.

  12. The dual specificity PI3K/mTOR inhibitor PKI-587 displays efficacy against T-cell acute lymphoblastic leukemia (T-ALL).

    Science.gov (United States)

    Gazi, Mohiuddin; Moharram, Sausan A; Marhäll, Alissa; Kazi, Julhash U

    2017-04-28

    Although significant improvements have been made in the treatment of acute lymphoblastic leukemia (ALL), there is a substantial subset of high-risk T-cell ALL (T-ALL) patients with relatively poor prognosis. Like in other leukemia types, alterations of the PI3K/mTOR pathway are predominant in ALL which is also responsible for treatment failure and relapse. In this study, we show that relapsed T-ALL patients display an enrichment of the PI3K/mTOR pathway. Using a panel of inhibitors targeting multiple components of the PI3K/mTOR pathway, we observed that the dual-specific PI3K/mTOR inhibitor PKI-587 was the most selective inhibitor for T-ALL cells dependent on the PI3K/mTOR pathway. Furthermore, we observed that PKI-587 blocked proliferation and colony formation of T-ALL cell lines. Additionally, PKI-587 selectively abrogated PI3K/mTOR signaling without affecting MAPK signaling both in in vitro and in vivo. Inhibition of the PI3K/mTOR pathway using PKI-587 delayed tumor progression, reduced tumor load and enhanced the survival rate in immune-deficient mouse xenograft models without inducing weight loss in the inhibitor treated mice. This preclinical study shows beneficial effects of PKI-587 on T-ALL that warrants further investigation in the clinical setting. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. In vivo dynamics and kinetics of pKi-67: Transition from a mobile to an immobile form at the onset of anaphase

    International Nuclear Information System (INIS)

    Saiwaki, Takuya; Kotera, Ippei; Sasaki, Mitsuho; Takagi, Masatoshi; Yoneda, Yoshihiro

    2005-01-01

    A cell proliferation marker protein, pKi-67, distributes to the chromosome periphery during mitosis and nucleolar heterochromatin in the interphase. We report here on the structural domains of pKi-67 that are required for its correct distribution. While both the LR domain and the conserved domain were involved in localization to the nucleolar heterochromatin, both the LR domain and the Ki-67 repeat domain were required for its distribution to the mitotic chromosome periphery. Using in vivo time-lapse microscopy, GFP-pKi-67 was dynamically tracked from the mitotic chromosome periphery to reforming nucleoli via prenucleolar bodies (PNBs). The signals in PNBs then moved towards and fused into the reforming nucleoli with a thin string-like fluorescence during early G1 phase. An analysis of the in vivo kinetics of pKi-67 using photobleaching indicated that the association of pKi-67 with chromatin was progressively altered from 'loose' to 'tight' after the onset of anaphase. These findings indicate that pKi-67 dynamically alters the nature of the interaction with chromatin structure during the cell cycle, which is closely related to the reformation process of the interphase nucleolar chromatin

  14. Authentication Architecture for Region-Wide e-Health System with Smartcards and a PKI

    Science.gov (United States)

    Zúquete, André; Gomes, Helder; Cunha, João Paulo Silva

    This paper describes the design and implementation of an e-Health authentication architecture using smartcards and a PKI. This architecture was developed to authenticate e-Health Professionals accessing the RTS (Rede Telemática da Saúde), a regional platform for sharing clinical data among a set of affiliated health institutions. The architecture had to accommodate specific RTS requirements, namely the security of Professionals' credentials, the mobility of Professionals, and the scalability to accommodate new health institutions. The adopted solution uses short-lived certificates and cross-certification agreements between RTS and e-Health institutions for authenticating Professionals accessing the RTS. These certificates carry as well the Professional's role at their home institution for role-based authorization. Trust agreements between e-Health institutions and RTS are necessary in order to make the certificates recognized by the RTS. As a proof of concept, a prototype was implemented with Windows technology. The presented authentication architecture is intended to be applied to other medical telematic systems.

  15. Scientific Grid activities and PKI deployment in the Cybermedia Center, Osaka University.

    Science.gov (United States)

    Akiyama, Toyokazu; Teranishi, Yuuichi; Nozaki, Kazunori; Kato, Seiichi; Shimojo, Shinji; Peltier, Steven T; Lin, Abel; Molina, Tomas; Yang, George; Lee, David; Ellisman, Mark; Naito, Sei; Koike, Atsushi; Matsumoto, Shuichi; Yoshida, Kiyokazu; Mori, Hirotaro

    2005-10-01

    The Cybermedia Center (CMC), Osaka University, is a research institution that offers knowledge and technology resources obtained from advanced researches in the areas of large-scale computation, information and communication, multimedia content and education. Currently, CMC is involved in Japanese national Grid projects such as JGN II (Japan Gigabit Network), NAREGI and BioGrid. Not limited to Japan, CMC also actively takes part in international activities such as PRAGMA. In these projects and international collaborations, CMC has developed a Grid system that allows scientists to perform their analysis by remote-controlling the world's largest ultra-high voltage electron microscope located in Osaka University. In another undertaking, CMC has assumed a leadership role in BioGrid by sharing its experiences and knowledge on the system development for the area of biology. In this paper, we will give an overview of the BioGrid project and introduce the progress of the Telescience unit, which collaborates with the Telescience Project led by the National Center for Microscopy and Imaging Research (NCMIR). Furthermore, CMC collaborates with seven Computing Centers in Japan, NAREGI and National Institute of Informatics to deploy PKI base authentication infrastructure. The current status of this project and future collaboration with Grid Projects will be delineated in this paper.

  16. PKI-based secure mobile access to electronic health services and data.

    Science.gov (United States)

    Kambourakis, G; Maglogiannis, I; Rouskas, A

    2005-01-01

    Recent research works examine the potential employment of public-key cryptography schemes in e-health environments. In such systems, where a Public Key Infrastructure (PKI) is established beforehand, Attribute Certificates (ACs) and public key enabled protocols like TLS, can provide the appropriate mechanisms to effectively support authentication, authorization and confidentiality services. In other words, mutual trust and secure communications between all the stakeholders, namely physicians, patients and e-health service providers, can be successfully established and maintained. Furthermore, as the recently introduced mobile devices with access to computer-based patient record systems are expanding, the need of physicians and nurses to interact increasingly with such systems arises. Considering public key infrastructure requirements for mobile online health networks, this paper discusses the potential use of Attribute Certificates (ACs) in an anticipated trust model. Typical trust interactions among doctors, patients and e-health providers are presented, indicating that resourceful security mechanisms and trust control can be obtained and implemented. The application of attribute certificates to support medical mobile service provision along with the utilization of the de-facto TLS protocol to offer competent confidentiality and authorization services is also presented and evaluated through experimentation, using both the 802.11 WLAN and General Packet Radio Service (GPRS) networks.

  17. Stereoselective synthesis of an active metabolite of the potent PI3 kinase inhibitor PKI-179.

    Science.gov (United States)

    Chen, Zecheng; Venkatesan, Aranapakam M; Dos Santos, Osvaldo; Delos Santos, Efren; Dehnhardt, Christoph M; Ayral-Kaloustian, Semiramis; Ashcroft, Joseph; McDonald, Leonard A; Mansour, Tarek S

    2010-03-05

    The synthesis and stereochemical determination of 1-(4-(4-((1R,5R,6R)-6-hydroxy-3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-4-yl)urea (2), an active metabolite of the potent PI3 kinase inhibitor PKI-179 (1), is described. Stereospecific hydroboration of the double bond of 2,5-dihydro-1H-pyrrole 8 gave the 2,3-trans alcohol 9 exclusively. The configuration of the 3-hydroxyl group in 9 was inverted by an oxidation and stereoselective reduction sequence to give the corresponding 2,3-cis isomer 23. Both exo (21) and endo (27) isomers of the metabolite 2 were prepared via a practical synthetic route from 9 and 23, respectively, and the stereochemistry of 2 was determined to be endo. The endo isomer (27) was separated into two enantiomers 28 and 29 by chiral HPLC. Compound 2 was found to be enantiomerically pure and identical to the enantiomer 28. The absolute stereochemistry of the enantiomer 28 was determined by Mosher's method, thus establishing the stereochemistry of the active metabolite 2.

  18. Collaborative Co-Design for Library Workshops

    Science.gov (United States)

    Roberts, Regina Lee; Taormina, Mattie

    2013-01-01

    This article describes a year-long application of critical information literacy theory for social-science-related library workshops. Each of these workshops had a customized section that included working with special collections and university archives. The students who participated ranged from incoming freshman to seniors at Stanford University.…

  19. The Future Workshop: Democratic problem solving

    DEFF Research Database (Denmark)

    Vidal, Rene Victor Valqui

    2005-01-01

    The origins, principles and practice of a very popular method known as The Future Workshop are presented. The fundamental theory and principles of this method are presented in an introductory way. In addition, practical guidelines to carry out such a workshop are outlined and several types of app...

  20. MATHEON Workshop 2013

    CERN Document Server

    Calderbank, Robert; Kutyniok, Gitta; Vybíral, Jan

    2015-01-01

    Since publication of the initial papers in 2006, compressed sensing has captured the imagination of the international signal processing community, and the mathematical foundations are nowadays quite well understood. Parallel to the progress in mathematics, the potential applications of compressed sensing have been explored by many international groups of, in particular, engineers and applied mathematicians, achieving very promising advances in various areas such as communication theory, imaging sciences, optics, radar technology, sensor networks, or tomography. Since many applications have reached a mature state, the research center MATHEON in Berlin focusing on "Mathematics for Key Technologies", invited leading researchers on applications of compressed sensing from mathematics, computer science, and engineering to the "MATHEON Workshop 2013: Compressed Sensing and its Applications” in December 2013. It was the first workshop specifically focusing on the applications of compressed sensing. This book featur...

  1. Activity report for feasibility study on PKI authentication method with IC card in authentication system sub group of J-PARC information system group

    International Nuclear Information System (INIS)

    Teshima, Naoya; Aoyagi, Tetsuo; Nakajima, Norihiro; Hashimoto, Kiyoharu; Manabe, Atsushi; Yuasa, Fukuko

    2009-06-01

    The Authentication System Sub Group of J-PARC Information System Group completed the mapping of the several authentication methods in terms of the level of security. Of the methods, the PKI authentication method with IC card provides the Super High Security Level and will be adopted as the authentication method of several J-PARC Information Systems. We study the feasibility of this method with following four examples; (1) 'The EAP-TLS wireless LAN authentication method'. (2) 'The Web-SSL client authentication method in SSL-VPN connection'. (3) 'The PKI authentication method with a certificate issued by NAREGI-CA software stored in IC card.' (4) 'The PKI authentication method with Dual interface FeliCa card'. In each example, we confirmed the feasibility of the method in a practical way. In this report we present the details of the study. (author)

  2. Collider workshop

    International Nuclear Information System (INIS)

    Anon.

    1982-01-01

    The promise of initial results after the start of operations at CERN's SPS proton-antiproton collider and the prospects for high energy hadron collisions at Fermilab (Tevatron) and Brookhaven (ISABELLE) provided a timely impetus for the recent Topical Workshop on Forward Collider Physics', held at Madison, Wisconsin, from 10-12 December. It became the second such workshop to be held, the first having been in 1979 at the College de France, Paris. The 100 or so participants had the chance to hear preliminary results from the UA1, UA4 and UA5 experiments at the CERN SPS collider, together with other new data, including that from proton-antiproton runs at the CERN Intersecting Storage Rings

  3. Workshop presentations

    International Nuclear Information System (INIS)

    Sanden, Per-Olof; Edland, Anne; Reiersen, Craig; Mullins, Peter; Ingemarsson, Karl-Fredrik; Bouchard, Andre; Watts, Germaine; Johnstone, John; Hollnagel, Erik; Ramberg, Patric; Reiman, Teemu

    2009-01-01

    An important part of the workshop was a series of invited presentations. The presentations were intended to both provide the participants with an understanding of various organisational approaches and activities as well as to stimulate the exchange of ideas during the small group discussion sessions. The presentation subjects ranged from current organisational regulations and licensee activities to new organisational research and the benefits of viewing organisations from a different perspective. There were more than a dozen invited presentations. The initial set of presentations gave the participants an overview of the background, structure, and aims of the workshop. This included a short presentation on the results from the regulatory responses to the pre-workshop survey. Representatives from four countries (Sweden, Canada, Finland, and the United Kingdom) expanded upon their survey responses with detailed presentations on both regulatory and licensee safety-related organisational activities in their countries. There were also presentations on new research concerning how to evaluate safety critical organisations and on a resilience engineering perspective to safety critical organisations. Below is the list of the presentations, the slides of which being available in Appendix 2: 1 - Workshop Welcome (Per-Olof Sanden); 2 - CSNI Working Group on Human and Organisational Factors (Craig Reiersen); 3 - Regulatory expectations on justification of suitability of licensee organisational structures, resources and competencies (Anne Edland); 4 - Justifying the suitability of licensee organisational structures, resources and competencies (Karl-Fredrik Ingemarsson); 5 - Nuclear Organisational Suitability in Canada (Andre Bouchard); 6 - Designing and Resourcing for Safety and Effectiveness (Germaine Watts); 7 - Organisational Suitability - What do you need and how do you know that you've got it? (Craig Reiersen); 8 - Suitability of Organisations - UK Regulator's View (Peter

  4. Using PKiKP coda to study heterogeneity in the top layer of the inner core's western hemisphere

    Science.gov (United States)

    Wu, Wenbo; Irving, Jessica C. E.

    2017-05-01

    Significant lateral and depth variations of the inner core's properties, such as the large-scale hemispherical pattern, have been confirmed by a variety of seismological observations. However it is still unclear which dynamic processes in the core are responsible for these variations. Small-scale volumetric heterogeneity has been detected in the top layer of the inner core by PKiKP coda observations. Studies of these small-scale heterogeneities can provide critical information, such as the degree of alignment of iron crystals, the presence of possible partial melt and the grain size of iron crystals, all of which can be used to constrain the dynamic processes of the inner core. However, most previous observations sampled the inner core beneath the Pacific Ocean and Asia, often in the inner core's 'eastern hemisphere'. We use seismic stations in the North America, including the Earthscope Transportable Array, to look at PKiKP and its coda waves. We find 21 events with clear signals. In agreement with previous studies, inner core scattering (ICS), resulting in clear PKiKP coda, is found at epicentral distances of 60°-95°. However, the ICS we observe in these 21 western hemisphere events is weaker than previously reported for the eastern hemisphere. Comparing our observations with numerical simulations, we conclude that this relatively weak ICS indicates small-scale heterogeneity in at least the top layer of the inner core beneath Central America. Combining our clear observations with previous studies suggests either a hemispherical difference, or a regional variation, of small-scale heterogeneity in the inner core.

  5. pKI values of prazosin and idazoxan for receptors stimulated by neuronally released transmitter in the epididymal portion of rat isolated vas deferens.

    OpenAIRE

    Mackay, D.; Kengatharan, M.

    1994-01-01

    1. A new method has been used to measure pKI values of prazosin and idazoxan against neuronally-released transmitter in the epididymal portion of the rat isolated vas deferens. The most reproducible results were obtained with a prolonged antagonist equilibration time (1 h). 2. Under these conditions the pKI of prazosin was practically unaffected by addition of alpha, beta-methylene-adenosine-5'-triphosphate (10 microM) to desensitize purinoceptors. Addition of desmethylimipramine (DMI) (0.3 m...

  6. PKI-179: an orally efficacious dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor.

    Science.gov (United States)

    Venkatesan, Aranapakam M; Chen, Zecheng; dos Santos, Osvaldo; Dehnhardt, Christoph; Santos, Efren Delos; Ayral-Kaloustian, Semiramis; Mallon, Robert; Hollander, Irwin; Feldberg, Larry; Lucas, Judy; Yu, Ker; Chaudhary, Inder; Mansour, Tarek S

    2010-10-01

    A series of mono-morpholino 1,3,5-triazine derivatives (8a-8q) bearing a 3-oxa-8-azabicyclo[3.2.1]octane were prepared and evaluated for PI3-kinase/mTOR activity. Replacement of one of the bis-morpholines in lead compound 1 (PKI-587) with 3-oxa-8-azabicyclo[3.2.1]octane and reduction of the molecular weight yielded 8m (PKI-179), an orally efficacious dual PI3-kinase/mTOR inhibitor. The in vitro activity, in vivo efficacy, and PK properties of 8m are discussed. Copyright © 2010. Published by Elsevier Ltd.

  7. Workshops som forskningsmetode

    OpenAIRE

    Ørngreen, Rikke; Levinsen, Karin Tweddell

    2017-01-01

    This paper contributes to knowledge on workshops as a research methodology, and specifically on how such workshops pertain to e-learning. A literature review illustrated that workshops are discussed according to three different perspectives: workshops as a means, workshops as practice, and workshops as a research methodology. Focusing primarily on the latter, this paper presents five studies on upper secondary and higher education teachers’ professional development and on teaching and learnin...

  8. Creating Fantastic PI Workshops

    Energy Technology Data Exchange (ETDEWEB)

    Biedermann, Laura B. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Clark, Blythe G. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Colbert, Rachel S. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Dagel, Amber Lynn [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gupta, Vipin P. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hibbs, Michael R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Perkins, David Nikolaus [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); West, Roger Derek [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-10-01

    The goal of this SAND report is to provide guidance for other groups hosting workshops and peerto-peer learning events at Sandia. Thus this SAND report provides detail about our team structure, how we brainstormed workshop topics and developed the workshop structure. A Workshop “Nuts and Bolts” section provides our timeline and check-list for workshop activities. The survey section provides examples of the questions we asked and how we adapted the workshop in response to the feedback.

  9. Desnarrativas: workshop

    Directory of Open Access Journals (Sweden)

    Ivânia Marques

    2014-08-01

    Full Text Available This is a report of a teacher workshop. It was an encounter among dialogues, pictures and possibilities of deconstruction in multiple directions. It enables studies inspiring debate in favor of images. Images are loaded with clichés and they risk breaking with the documentary/real character of photography. It leads us to think of the non-neutrality of an image and how the place is hegemonically imposed on us. It does away with blocking forces in a playful experimentation. The experimentation is extended into compositions with photographs, monotype printing, and different ways of perceiving space, dialogues, exchanges, poems and art.

  10. Workshop experience

    Directory of Open Access Journals (Sweden)

    Georgina Holt

    2007-04-01

    Full Text Available The setting for the workshop was a heady mix of history, multiculturalism and picturesque riverscapes. Within the group there was, as in many food studies, a preponderance of female scientists (or ethnographers, but the group interacted on lively, non-gendered terms - focusing instead on an appreciation of locals food and enthusiasm for research shared by all, and points of theoretical variance within that.The food provided by our hosts was of the very highest eating and local food qualities...

  11. Recent Workshops

    CERN Multimedia

    Wickens, F. J.

    Since the previous edition of ATLAS e-news, the NIKHEF Institute in Amsterdam has hosted not just one but two workshops related to ATLAS TDAQ activities. The first in October was dedicated to the Detector Control System (DCS). Just three institutes, CERN, NIKHEF and St Petersburg, provide the effort for the central DCS services, but each ATLAS sub-detector provides effort for their own controls. Some 30 people attended, including representatives for all of the ATLAS sub-detectors, representatives of the institutes working on the central services and the project leader of JCOP, which brings together common aspects of detector controls across the LHC experiments. During the three-day workshop the common components were discussed, and each sub-detector described their experiences and plans for their future systems. Whilst many of the components to be used are standard commercial components, a key custom item for ATLAS is the ELMB (Embedded Local Monitor Board). Prototypes for this have now been extensively test...

  12. Fourth Latin-American workshop on plasma physics. Contributed papers

    International Nuclear Information System (INIS)

    1990-01-01

    The main goal of this series of Workshops is to provide a periodic meeting place for Latin-American researchers in plasma physics together with colleagues from other countries around the world. This volume includes the contributed papers presented at the Workshop on Plasma Physics held in Buenos Aires in 1990. The scope of the Workshop can be synthesized in the following main subjects: Tokamak experiments and theory; alternative confinement systems and basic experiments; technology and applications; general theory; astrophysical and space plasmas

  13. Alterations in brain Protein Kinase A activity and reversal of morphine tolerance by two fragments of native Protein Kinase A inhibitor peptide (PKI).

    Science.gov (United States)

    Dalton, George D; Smith, Forrest L; Smith, Paul A; Dewey, William L

    2005-04-01

    Two peptide fragments of native Protein Kinase A inhibitor (PKI), PKI-(6-22)-amide and PKI-(Myr-14-22)-amide, significantly reversed low-level morphine antinociceptive tolerance in mice. The inhibition of Protein Kinase A (PKA) activity by both peptide fragments was then measured in specific brain regions (thalamus, periaqueductal gray (PAG), and medulla) and in lumbar spinal cord (LSC), which in previous studies have been shown to play a role in morphine-induced analgesia. In drug naive animals, cytosolic PKA activity was greater than particulate PKA activity in each region, while cytosolic and particulate PKA activities were greater in thalamus and PAG compared to medulla and LSC. The addition of both peptides to homogenates from each region completely abolished cytosolic and particulate PKA activities in vitro. Following injection into the lateral ventricle of the brain of drug naive mice and morphine-tolerant mice, both peptides inhibited PKA activity in the cytosolic, but not the particulate fraction of LSC. In addition, cytosolic and particulate PKA activities were inhibited by both peptides in thalamus. These results demonstrate that the inhibition of PKA reverses morphine tolerance. Moreover, the inhibition of PKA activity in specific brain regions and LSC from morphine-tolerant mice by PKI analogs administered i.c.v. is evidence that PKA plays a role in morphine tolerance.

  14. Growth inhibitory effects of the dual ErbB1/ErbB2 tyrosine kinase inhibitor PKI-166 on human prostate cancer xenografts.

    Science.gov (United States)

    Mellinghoff, Ingo K; Tran, Chris; Sawyers, Charles L

    2002-09-15

    Experiments with human prostate cancer cell lines have shown that forced overexpression of the ErbB2-receptor tyrosine kinase (RTK) promotes androgen-independent growth and increases androgen receptor-transcriptional activity in a ligand-independent fashion. To investigate the relationship between ErbB-RTK signaling and androgen in genetically unmanipulated human prostate cancer, we performed biochemical and biological studies with the dual ErbB1/ErbB2 RTK inhibitor PKI-166 using human prostate cancer xenograft models with isogenic sublines reflecting the transition from androgen-dependent to androgen-independent growth. In the presence of low androgen concentrations, PKI-166 showed profound growth-inhibitory effects on tumor growth, which could be partially reversed by androgen add-back. At physiological androgen concentrations, androgen withdrawal greatly enhanced the ability of PKI-166 to retard tumor growth. The level of extracellular signal-regulated kinase activation correlated with the response to PKI-166 treatment, whereas the expression levels of ErbB1 and ErbB2 did not. These results suggest that ErbB1/ErbB2 RTKs play an important role in the biology of androgen-independent prostate cancer and provide a rationale for clinical evaluation of inhibitors targeted to this pathway.

  15. MICCAI Workshops

    CERN Document Server

    Nedjati-Gilani, Gemma; Venkataraman, Archana; O'Donnell, Lauren; Panagiotaki, Eleftheria

    2014-01-01

    This volume contains the proceedings from two closely related workshops: Computational Diffusion MRI (CDMRI’13) and Mathematical Methods from Brain Connectivity (MMBC’13), held under the auspices of the 16th International Conference on Medical Image Computing and Computer Assisted Intervention, which took place in Nagoya, Japan, September 2013. Inside, readers will find contributions ranging from mathematical foundations and novel methods for the validation of inferring large-scale connectivity from neuroimaging data to the statistical analysis of the data, accelerated methods for data acquisition, and the most recent developments on mathematical diffusion modeling. This volume offers a valuable starting point for anyone interested in learning computational diffusion MRI and mathematical methods for brain connectivity as well as offers new perspectives and insights on current research challenges for those currently in the field. It will be of interest to researchers and practitioners in computer science, ...

  16. Dual PI3K/mTOR inhibitors, GSK2126458 and PKI-587, suppress tumor progression and increase radiosensitivity in nasopharyngeal carcinoma.

    Science.gov (United States)

    Liu, Tongxin; Sun, Quanquan; Li, Qi; Yang, Hua; Zhang, Yuqin; Wang, Rong; Lin, Xiaoshan; Xiao, Dong; Yuan, Yawei; Chen, Longhua; Wang, Wei

    2015-02-01

    Although combined chemoradiotherapy has provided considerable improvements for nasopharyngeal carcinoma (NPC), recurrence and metastasis are still frequent. The PI3K/Akt/mTOR pathway plays a critical role in tumor formation and tumor cell survival after radiation-induced DNA damage. In the present study, we evaluated whether inhibition of PI3K/mTOR by two novel dual inhibitors, GSK2126458 and PKI-587, could suppress tumor progression and sensitize NPC cells to radiation. Four NPC cell lines (CNE-1, CNE-2, 5-8F, and 6-10B) were used to analyze the effects of GSK216458 and PKI-587 on cell proliferation, migration, invasion, clonogenic survival, amount of residual γ-H2AX foci, cell cycle, and apoptosis after radiation. A 5-8F xenograft model was used to evaluate the in vivo effects of the two compounds in combination with ionizing radiation (IR). Both GSK216458 and PKI-587 effectively inhibited cell proliferation and motility in NPC cells and suppressed phosphorylation of Akt, mTOR, S6, and 4EBP1 proteins in a concentration- and time-dependent manner. Moreover, both compounds sensitized NPC cells to IR by increasing DNA damage, enhancing G2-M cell-cycle delay, and inducing apoptosis. In vivo, the combination of IR with GSK2126458 or PKI-587 significantly inhibited tumor growth. Antitumor effect was correlated with induction of apoptosis and suppression of the phosphorylation of mTOR, Akt, and 4EBP1. These new findings suggest the usefulness of PI3K/mTOR dual inhibition for antitumor and radiosensitizing. The combination of IR with a dual PI3K/mTOR inhibitor, GSK2126458 or PKI-587, might be a promising therapeutic strategy for NPC. ©2014 American Association for Cancer Research.

  17. Computer-Assisted Language Learning : proceedings of the seventh Twente Workshop on Language Technology

    NARCIS (Netherlands)

    Appelo, L.; de Jong, Franciska M.G.

    1994-01-01

    TWLT is an acronym of Twente Workshop(s) on Language Technology. These workshops on natural language theory and technology are organised bij Project Parlevink (sometimes with the help of others) a language theory and technology project conducted at the Department of Computer Science of the

  18. Organising stakeholder workshops in research and innovation

    DEFF Research Database (Denmark)

    Nielsen, Morten Velsing; Bryndum, Nina; Bedsted, Bjørn

    2017-01-01

    This article addresses the theory and practice of creating responsiveness among actors through deliberative dialogue processes with stakeholders from diverse institutional settings. The EU’s decision to mainstream stakeholder deliberation in research and innovation, as part of its focus......, the article illustrates the challenges of applying theory to five European stakeholder workshops co-organised by the authors. The illustration highlights the difficult interaction between theory and practice. The article concludes that while theoretical perspectives can provide general guidance, practical...... experience is essential when dealing with the trade-offs that are an intrinsic part of organising stakeholder workshops....

  19. The Future Workshop: Democratic problem solving

    Directory of Open Access Journals (Sweden)

    Rene Victor Valqui Vidal

    2006-03-01

    Full Text Available The origins, principles and practice of a very popular method known as The Future Workshop are presented. The fundamental theory and principles of this method are presented in an introductory way. In addition, practical guidelines to carry out such a workshop are outlined and several types of applications are shortly described. The crucial importance of both the facilitation process and the use of creative tools in team work are enhanced.

  20. Workshop 1: Geosynthetics in Transportation Geotechnics

    OpenAIRE

    Tatsuoka, Fumio; Zornberg, Jorge; Machado do Vale, José Luís; Neves, José

    2016-01-01

    This book contains the extended abstracts of the Workshop 1 - Geosynthetics in Transportation Geotechnics - of the 3rd International Conference on Transportation Geotechnics, 4-7 September 2016, Guimarães, Portugal. The main goals of the workshop were: state-of-the-art of the use of geosynthetics in transportation geotechnics; theory and research of geosynthetics engineering for transportation engineering; key issues in practice; and perspective.

  1. Synthesis, characterization and inhibitory activities of (4-N3[3,5-3H]Phe10)PKI(6-22)amide and its precursors: photoaffinity labeling peptides for the active site of cyclic AMP-dependent protein kinase.

    Science.gov (United States)

    Katz, B M; Lundquist, L J; Walsh, D A; Glass, D B

    1989-06-01

    PKI(6-22)amide is a 17 residue peptide corresponding to the active portion of the heat-stable inhibitor of cAMP-dependent protein kinase. The peptide is a potent (Ki = 1.6 nM), competitive inhibitor of the enzyme. The photoreactive peptide analog (4-azidophenylalanine10)PKI(6-22)amide was synthesized in both its non-radiolabeled and tritiated forms by chemical modification of precursor peptides that were prepared by stepwise solid-phase synthesis. (4-Amino[3,5-3H]phenylalanine10)PKI(6-22)amide, the precursor for the radiolabeled arylazide peptide, was obtained by catalytic reduction of the corresponding peptide containing the 3,5-diiodo-4-aminophenylalanine residue at position 10. The purified PKI peptides were analyzed by HPLC, amino acid analysis, and u.v. spectra. In the dark, (4-azidophenylalanine10)PKI(6-22)amide inhibited the catalytic subunit of cAMP-dependent protein kinase with a Ki value of 2.8 nM. The photoreactivity of the arylazide peptide was demonstrated by time-dependent u.v. spectral changes on exposure to light. Photolysis of the catalytic subunit (4-azido[3,5-3H]phenylalanine10)PKI(6-22)amide complex resulted in specific covalent labeling of the enzyme. The data indicate that this peptide is a useful photoaffinity labeling reagent for the active site of the protein kinase.

  2. Order Theory in Environmental Sciences

    DEFF Research Database (Denmark)

    Sørensen, P. B.; Brüggemann, R.; Lerche, D. B.

    This is the proceeding from the fifth workshop in Order Theory in Environ-mental Science. In this workshop series the concept of Partial Order Theory is development in relation to application and the use is tested based on specific problems. The Partial Order Theory will have a potential use...

  3. A structural insight into the inhibitory mechanism of an orally active PI3K/mTOR dual inhibitor, PKI-179 using computational approaches.

    Science.gov (United States)

    Mohd Rehan

    2015-11-01

    The PI3K/AKT/mTOR signaling pathway has been identified as an important target for cancer therapy. Attempts are increasingly made to design the inhibitors against the key proteins of this pathway for anti-cancer therapy. The PI3K/mTOR dual inhibitors have proved more effective than the inhibitors against only single protein targets. Recently discovered PKI-179, an orally effective compound, is one such dual inhibitor targeting both PI3K and mTOR. This anti-cancer compound is efficacious both in vitro and in vivo. However, the binding mechanisms and the molecular interactions of PKI-179 with PI3K and mTOR are not yet available. The current study investigated the exact binding mode and the molecular interactions of PKI-179 with PI3Kγ and mTOR using molecular docking and (un)binding simulation analyses. The study identified PKI-179 interacting residues of both the proteins and their importance in binding was ranked by the loss in accessible surface area, number of molecular interactions of the residue, and consistent appearance of the residue in (un)binding simulation analysis. The key residues involved in binding of PKI-179 were Ala-805 in PI3Kγ and Ile-2163 in mTOR as they have lost maximum accessible surface area due to binding. In addition, the residues which played a role in binding of the drug but were away from the catalytic site were also identified using (un)binding simulation analyses. Finally, comparison of the interacting residues in the respective catalytic sites was done for the difference in the binding of the drug to the two proteins. Thus, the pairs of the residues falling at the similar location with respect to the docked drug were identified. The striking similarity in the interacting residues of the catalytic site explains the concomitant inhibition of both proteins by a number of inhibitors. In conclusion, the docking and (un)binding simulation analyses of dual inhibitor PKI-179 with PI3K and mTOR will provide a suitable multi-target model for

  4. Workshop introduction

    International Nuclear Information System (INIS)

    Streeper, Charles

    2010-01-01

    The Department of Energy's National Nuclear Security Administration's Global Threat Reduction Initiative (GTRI) has three subprograms that directly reduce the nuclear/radiological threat; Convert (Highly Enriched Uranium), Protect (Facilities), and Remove (Materials). The primary mission of the Off-Site Source Recovery Project (OSRP) falls under the 'Remove' subset. The purpose of this workshop is to provide a venue for joint-technical collaboration between the OSRP and the Nuclear Radiation Safety Service (NRSS). Eisenhower's Atoms for Peace initiative and the Soviet equivalent both promoted the spread of the paradoxical (peaceful and harmful) properties of the atom. The focus of nonproliferation efforts has been rightly dedicated to fissile materials and the threat they pose. Continued emphasis on radioactive materials must also be encouraged. An unquantifiable threat still exists in the prolific quantity of sealed radioactive sources (sources) spread worldwide. It does not appear that the momentum of the evolution in the numerous beneficial applications of radioactive sources will subside in the near future. Numerous expert studies have demonstrated the potentially devastating economic and psychological impacts of terrorist use of a radiological dispersal or emitting device. The development of such a weapon, from the acquisition of the material to the technical knowledge needed to develop and use it, is straightforward. There are many documented accounts worldwide of accidental and purposeful diversions of radioactive materials from regulatory control. The burden of securing sealed sources often falls upon the source owner, who may not have a disposal pathway once the source reaches the end of its useful life. This disposal problem is exacerbated by some source owners not having the resources to safely and compliantly store them. US Nuclear Regulatory Commission (NRC) data suggests that, in the US alone, there are tens of thousands of high-activity (IAEA

  5. Nuclear physics workshop

    International Nuclear Information System (INIS)

    1988-01-01

    This Workshop in Nuclear Physics related to the TANDAR, took place in Buenos Aires in April from 23 to 26, 1987, with attendance of foreign scientists. There were presented four seminars and a lot of studies which deal with the following fields: Nuclear Physics at medium energies, Nuclear Structure, Nuclear Reactions, Nuclear Matter, Instrumentation and Methodology for Nuclear Spectroscopy, Classical Physics, Quantum Mechanics and Field Theory. It must be emphasized that the Electrostatic Accelerator TANDAR allows to work with heavy ions of high energy, that opens a new field of work in PIXE (particle induced X-ray emission). This powerful analytic technique makes it possiblethe analysis of nearly all the elements of the periodic table with the same accuracy. (M.E.L.) [es

  6. Failure points in the PKI architecture / Точки отказа в PKI архитектуре / Tačke otkaza u PKI arhitekturi

    Directory of Open Access Journals (Sweden)

    Radomir I. Prodanović

    2017-07-01

    Full Text Available Over the last 20 years, the PKI architecture has found its vast application, especially in the fields which require the establishment of a security infrastructure. Given that the purpose of this architecture is to be used for achieving higher security standards, its smooth operation has to be one of the main requirements for its implementation. Its complexity is mirrored in the numerous implementations that the PKI has had so far. For all the reasons mentioned above, it is of great importance to consider potential failure points of such a structure. Due to the complexity of these structures, this paper will present only a basic review of such stress points, without providing details on specific applications and types of implementations. The significance of failure points will be explained by examining the common features of the PKI architectures and the occurrence of failure points in these structures, and where possible, an overview of suggestions for preventing such failures will be provided. / За последних двадцать лет, архитектура PKI стала широко применяться, особенно в областях, требующих создания инфраструктуры безопасности. Учитывая, что цель создания такой архитектуры заключается в обеспечении безопасности систем, главными задачами при внедрении архитектуры PKI являются бесперебойная работа и взаимодействие с другими компонентами комплектной структуры. Из вышеизложенного следует, что прогноз потенциальных точек отказа представляет собой исключительно важный фактор. В связи с ограничением объема

  7. IPHE Infrastructure Workshop Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    None

    2010-02-01

    This proceedings contains information from the IPHE Infrastructure Workshop, a two-day interactive workshop held on February 25-26, 2010, to explore the market implementation needs for hydrogen fueling station development.

  8. 2nd Ralf Yorque Workshop

    CERN Document Server

    1985-01-01

    These are the proceedings of the Second R. Yorque Workshop on Resource Management which took place in Ashland, Oregon on July 23-25, 1984. The purpose of the workshop is to provide an informal atmosphere for the discussion of resource assessment and management problems. Each participant presented a one hour morning talk; afternoons were reserved for informal chatting. The workshop was successful in stimulating ideas and interaction. The papers by R. Deriso, R. Hilborn and C. Walters all address the same basic issue, so they are lumped together. Other than that, the order to the papers in this volume was determined in the same fashion as the order of speakers during the workshop -- by random draw. Marc Mangel Department of Mathematics University of California Davis, California June 1985 TABLE OF CONTENTS A General Theory for Fishery Modeling Jon Schnute Data Transformations in Regression Analysis with Applications to Stock-Recruitment Relationships David Ruppert and Raymond J. Carroll ••••••. •�...

  9. Workshops as a Research Methodology

    Science.gov (United States)

    Ørngreen, Rikke; Levinsen, Karin

    2017-01-01

    This paper contributes to knowledge on workshops as a research methodology, and specifically on how such workshops pertain to e-learning. A literature review illustrated that workshops are discussed according to three different perspectives: workshops as a means, workshops as practice, and workshops as a research methodology. Focusing primarily on…

  10. Review of the theory and applications of Monte Carlo methods. Proceedings of a seminar-workshop, Oak Ridge, Tennessee, April 21-23, 1980

    International Nuclear Information System (INIS)

    Trubey, D.K.; McGill, B.L.

    1980-08-01

    This report consists of 24 papers which were presented at the seminar on Theory and Application of Monte Carlo Methods, held in Oak Ridge on April 21-23, plus a summary of the three-man panel discussion which concluded the seminar and two papers which were not given orally. These papers constitute a current statement of the state of the art of the theory and application of Monte Carlo methods for radiation transport problems in shielding and reactor physics

  11. Review of the theory and applications of Monte Carlo methods. Proceedings of a seminar-workshop, Oak Ridge, Tennessee, April 21-23, 1980

    Energy Technology Data Exchange (ETDEWEB)

    Trubey, D.K.; McGill, B.L. (eds.)

    1980-08-01

    This report consists of 24 papers which were presented at the seminar on Theory and Application of Monte Carlo Methods, held in Oak Ridge on April 21-23, plus a summary of the three-man panel discussion which concluded the seminar and two papers which were not given orally. These papers constitute a current statement of the state of the art of the theory and application of Monte Carlo methods for radiation transport problems in shielding and reactor physics.

  12. ICP-MS Workshop

    Energy Technology Data Exchange (ETDEWEB)

    Carman, April J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Eiden, Gregory C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2014-11-01

    This is a short document that explains the materials that will be transmitted to LLNL and DNN HQ regarding the ICP-MS Workshop held at PNNL June 17-19th. The goal of the information is to pass on to LLNL information regarding the planning and preparations for the Workshop at PNNL in preparation of the SIMS workshop at LLNL.

  13. Monopole Workshop

    International Nuclear Information System (INIS)

    Anon.

    1983-01-01

    Some 90 physicists from 13 countries gathered in October to examine new evidence and theories concerning the magnetic monopole. The venue was Wingspread, the last, but by no means least, of architect Frank Lloyd Wright's marvellous prairie houses, located in Racine, Wisconsin. While many physicists remain sceptical about magnetic monopoles, a growing number are speculating that they may have been made in the first blaze of creation. If found, monopoles would provide a profound clue as to the origin and nature of the universe

  14. The dual PI3K/mTOR inhibitor PKI-587 enhances sensitivity to cetuximab in EGFR-resistant human head and neck cancer models.

    Science.gov (United States)

    D'Amato, V; Rosa, R; D'Amato, C; Formisano, L; Marciano, R; Nappi, L; Raimondo, L; Di Mauro, C; Servetto, A; Fusciello, C; Veneziani, B M; De Placido, S; Bianco, R

    2014-06-10

    Cetuximab is the only targeted agent approved for the treatment of head and neck squamous cell carcinomas (HNSCC), but low response rates and disease progression are frequently reported. As the phosphoinositide 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) pathways have an important role in the pathogenesis of HNSCC, we investigated their involvement in cetuximab resistance. Different human squamous cancer cell lines sensitive or resistant to cetuximab were tested for the dual PI3K/mTOR inhibitor PF-05212384 (PKI-587), alone and in combination, both in vitro and in vivo. Treatment with PKI-587 enhances sensitivity to cetuximab in vitro, even in the condition of epidermal growth factor receptor (EGFR) resistance. The combination of the two drugs inhibits cells survival, impairs the activation of signalling pathways and induces apoptosis. Interestingly, although significant inhibition of proliferation is observed in all cell lines treated with PKI-587 in combination with cetuximab, activation of apoptosis is evident in sensitive but not in resistant cell lines, in which autophagy is pre-eminent. In nude mice xenografted with resistant Kyse30 cells, the combined treatment significantly reduces tumour growth and prolongs mice survival. Phosphoinositide 3-kinase/mammalian target of rapamycin inhibition has an important role in the rescue of cetuximab resistance. Different mechanisms of cell death are induced by combined treatment depending on basal anti-EGFR responsiveness.

  15. HTTR workshop (workshop on hydrogen production technology)

    International Nuclear Information System (INIS)

    Shiina, Yasuaki; Takizuka, Takakazu

    2004-12-01

    Various research and development efforts have been performed to solve the global energy and environmental problems caused by large consumption of fossil fuels. Research activities on advanced hydrogen production technology by the use of nuclear heat from high temperature gas cooled reactors, for example, have been flourished in universities, research institutes and companies in many countries. The Department of HTTR Project and the Department of Advanced Nuclear Heat Technology of JAERI held the HTTR Workshop (Workshop on Hydrogen Production Technology) on July 5 and 6, 2004 to grasp the present status of R and D about the technology of HTGR and the nuclear hydrogen production in the world and to discuss about necessity of the nuclear hydrogen production and technical problems for the future development of the technology. More than 110 participants attended the Workshop including foreign participants from USA, France, Korea, Germany, Canada and United Kingdom. In the Workshop, the presentations were made on such topics as R and D programs for nuclear energy and hydrogen production technologies by thermo-chemical or other processes. Also, the possibility of the nuclear hydrogen production in the future society was discussed. The workshop showed that the R and D for the hydrogen production by the thermo-chemical process has been performed in many countries. The workshop affirmed that nuclear hydrogen production could be one of the competitive supplier of hydrogen in the future. The second HTTR Workshop will be held in the autumn next year. (author)

  16. Applied antineutrino physics workshop

    International Nuclear Information System (INIS)

    Lund, James C.

    2008-01-01

    This workshop is the fourth one of a series that includes the Neutrino Geophysics Conference at Honolulu, Hawaii, which I attended in 2005. This workshop was organized by the Astro-Particle and Cosmology laboratory in the recently opened Condoret building of the University of Paris. More information, including copies of the presentations, on the workshop is available on the website: www.apc.univ-paris7.fr/AAP2007/. The workshop aims at opening neutrino physics to various fields such that it can be applied in geosciences, nuclear industry (reactor and spent fuel monitoring) and non-proliferation. The workshop was attended by over 60 people from Europe, USA, Asia and Brazil. The meeting was also attended by representatives of the Comprehensive nuclear-Test Ban Treaty (CTBT) and the International Atomic Energy Agency (IAEA). The workshop also included a workshop dinner on board of a river boat sailing the Seine river

  17. Risk Management Techniques and Practice Workshop Workshop Report

    Energy Technology Data Exchange (ETDEWEB)

    Quinn, T; Zosel, M

    2008-12-02

    vendor technical or business problems. HPC, by its very nature, is an exercise in multi-level risk management. Every aspect of stewarding HPCCs into the petascale era, from identification of the program drivers to the details of procurement actions and simulation environment component deployments, represents unprecedented challenges and requires effective risk management. The fundamental purpose of this workshop was to go beyond risk management processes as such and learn how to weave effective risk management practices, techniques, and methods into all aspects of migrating HPCCs into the next generation of leadership computing systems. This workshop was a follow-on to the Petascale System Integration Workshop hosted by Lawrence Berkeley National Laboratory (LBNL)/NERSC last year. It was intended to leverage and extend the risk management experience of the participants by looking for common best practices and unique processes that have been especially successful. This workshop assessed the effectiveness of tools and techniques that are or could be helpful in HPCC risk management, with a special emphasis on how practice meets process. As the saying goes: 'In theory, there is no difference between theory and practice. In practice there is'. Finally, the workshop brought together a network of experts who shared information as technology moves into the petascale era and beyond.

  18. Identification of cellular targets involved in cardiac failure caused by PKI in oncology: an approach combining pharmacovigilance and pharmacodynamics.

    Science.gov (United States)

    Patras de Campaigno, Emilie; Bondon-Guitton, Emmanuelle; Laurent, Guy; Montastruc, Francois; Montastruc, Jean-Louis; Lapeyre-Mestre, Maryse; Despas, Fabien

    2017-07-01

    The aims of the present study were to evaluate the risk of cardiac failure (CF) associated with 15 anticancer protein kinase inhibitors (PKIs) through a case/noncase analysis and to identify which PK(s) and pathways are involved in PKI-induced CF. In order to evaluate the risk of CF, adjusted reporting odds ratios (aRORs) were calculated for the 15 anticancer PKIs in the World Health Organization safety report database (VigiBase®). We realised a literature review to identify 21 protein kinases (PKs) that were possibly involved in CF caused by PKIs. Pearson correlation coefficients (r) between aRORs and affinity data of the 15 PKIs for the 21 PKs were calculated to identify the cellular target most likely to be involved in PKI-induced CF. A total of 141 601 individual case safety reports (ICSRs) were extracted from VigiBase® for the following PKIs: afatinib, axitinib, bosutinib, crizotinib, dasatinib, erlotinib, gefitinib, imatinib, lapatinib, nilotinib, pazopanib, ruxolitinib, sorafenib, sunitinib and vandetanib. Among them, 2594 ICSRs concerned CF. The disproportionality analysis revealed that, for dasatinib, imatinib, bosutinib, sunitinib and nilotinib, disproportionality for CF was significantly higher than for other PKIs, with aRORs of 2.52 [95% CI 2.26, 2.82], 1.79 (95% CI 1.57, 2.03), 1.73 (95% CI 1.18, 2.54), 1.67 (95% CI 1.51, 1.84) and 1.38 (95% CI 1.18, 1.61), respectively. Significant values for correlation coefficients between the product of dissociation constant (pKd) and aROR were observed for two non-receptor protein kinases: ABL1 (non-phosphorylated and phosphorylated forms) and ABL2 protein kinases, with values of r = 0.83 (P = 0.0001), r = 0.75 (P = 0.0014) and r = 0.78 (P = 0.0006), respectively. We observed a higher disproportionality for CF with dasatinib, imatinib, bosutinib, sunitinib and nilotinib than with other PKIs. In addition, the study highlighted the role of ABL tyrosine kinases in CF caused by anticancer PKIs. © 2017 The British

  19. Workshop on The Functional Analysis of Quantum Information Theory : a Collection of Notes Based on Lectures by Gilles Pisier, K. R. Parthasarathy, Vern Paulsen and Andreas Winter

    CERN Document Server

    Gupta, Ved Prakash; Sunder, V S

    2015-01-01

    This book provides readers with a concise introduction to current studies on operator-algebras and their generalizations, operator spaces and operator systems, with a special focus on their application in quantum information science. This basic framework for the mathematical formulation of quantum information can be traced back to the mathematical work of John von Neumann, one of the pioneers of operator algebras, which forms the underpinning of most current mathematical treatments of the quantum theory, besides being one of the most dynamic areas of twentieth century functional analysis. Today, von Neumann’s foresight finds expression in the rapidly growing field of quantum information theory. These notes gather the content of lectures given by a very distinguished group of mathematicians and quantum information theorists, held at the IMSc in Chennai some years ago, and great care has been taken to present the material as a primer on the subject matter. Starting from the basic definitions of operator space...

  20. TFTR/JET INTOR workshop on plasma transport tokamaks

    International Nuclear Information System (INIS)

    Singer, C.E.

    1985-01-01

    This report summarizes the proceedings of a Workshop on transport models for prediction and analysis of tokamak plasma confinement. Summaries of papers on theory, predictive modeling, and data analysis are included

  1. Systems Engineering Workshops | Wind | NREL

    Science.gov (United States)

    Workshops Systems Engineering Workshops The Wind Energy Systems Engineering Workshop is a biennial topics relevant to systems engineering and the wind industry. The presentations and agendas are available for all of the Systems Engineering Workshops: The 1st NREL Wind Energy Systems Engineering Workshop

  2. 77 FR 31371 - Public Workshop: Privacy Compliance Workshop

    Science.gov (United States)

    2012-05-25

    ... presentations, including the privacy compliance fundamentals, privacy and data security, and the privacy... DEPARTMENT OF HOMELAND SECURITY Office of the Secretary Public Workshop: Privacy Compliance... Homeland Security Privacy Office will host a public workshop, ``Privacy Compliance Workshop.'' DATES: The...

  3. CEBAF/SURA 1985 Summer Workshop

    International Nuclear Information System (INIS)

    Crannel, H.

    1985-12-01

    The 1985 Summer Workshop began a new phase of planning for the experimental program at CEBAF. One goal of the Workshop was to define and describe options for equipping the CEBAF and stations with experimental equipment. Starting with an initial list of options which grew out of discussions during the Winter of 1984 and the Spring of 1985, the five working groups met during the Workshop and developed their final reports, included in these proceedings. The program of the Workshop consisted of invited talks on both theoretical and experimental topics, and working group meetings. The five working groups, include: Magnetic Spectrometers; Large Acceptance Detectors and Low Intensity Beams; Internal Targets; Positrons; Theory. These proceedings begin with an overview of CEBAF, and a report on progress made by the Magnetic Spectrometer and Internal Target Working Groups prior to the Workshop. The next part contains the invited talks, presented in the order which they were given during the week. The final reports of the five working groups follow this, and the proceedings conclude with papers contributed to the Workshop

  4. Innovative confinement concepts workshop

    International Nuclear Information System (INIS)

    Kirkpatrick, R.C.

    1998-01-01

    The Innovative Confinement Concepts Workshop occurred in California during the week preceding the Second Symposium on Current Trends in International Fusion Research. An informal report was made to the Second Symposium. A summary of the Workshop concluded that some very promising ideas were presented, that innovative concept development is a central element of the restructured US DOE. Fusion Energy Sciences program, and that the Workshop should promote real scientific progress in fusion

  5. Emergency response workers workshop

    International Nuclear Information System (INIS)

    Agapeev, S.A.; Glukhikh, E.N.; Tyurin, R.L.

    2012-01-01

    A training workshop entitled Current issues and potential improvements in Rosatom Corporation emergency prevention and response system was held in May-June, 2012. The workshop combined theoretical training with full-scale practical exercise that demonstrated the existing innovative capabilities for radiation reconnaissance, diving equipment and robotics, aircraft, emergency response and rescue hardware and machinery. This paper describes the activities carried out during the workshop [ru

  6. Alternate fusion fuels workshop

    International Nuclear Information System (INIS)

    1981-06-01

    The workshop was organized to focus on a specific confinement scheme: the tokamak. The workshop was divided into two parts: systems and physics. The topics discussed in the systems session were narrowly focused on systems and engineering considerations in the tokamak geometry. The workshop participants reviewed the status of system studies, trade-offs between d-t and d-d based reactors and engineering problems associated with the design of a high-temperature, high-field reactor utilizing advanced fuels. In the physics session issues were discussed dealing with high-beta stability, synchrotron losses and transport in alternate fuel systems. The agenda for the workshop is attached

  7. MOOC Design Workshop

    DEFF Research Database (Denmark)

    Nørgård, Rikke Toft; Mor, Yishay; Warburton, Steven

    2016-01-01

    For the last two years we have been running a series of successful MOOC design workshops. These workshops build on previous work in learning design and MOOC design patterns. The aim of these workshops is to aid practitioners in defining and conceptualising educational innovations (predominantly......, but not exclusively MOOCs) which are based on an empathic user-centered view of the target learners and teachers. In this paper, we share the main principles, patterns and resources of our workshops and present some initial results for their effectiveness...

  8. Model for PKI interoperability in Serbia / Модель доверия и архетектура PKI в Республике Сербия / Model za PKI interoperabilnost u Republici Srbiji

    Directory of Open Access Journals (Sweden)

    Radomir I. Prodanović

    2017-04-01

    Full Text Available The increasing use of electronic services that use electronic certificates and the increasing implementation of public key infrastructures require their interconnection and interoperability. In this paper, the authors analyze the models for interoperability between various PKI domains and their possible application in achieving interoperability of the public key infrastructures in the Republic of Serbia. The implementation of the interoperability of the existing models is discussed from the following aspects: scalability, processing of certification paths, implementing policies, the points of failure and the possibilities of re-establishing trust. We proposed a conceptual model based on the Bridge Certification Authority trust model. This model can provide the establishment of the interoperability of both the existing and new national PKI domains, their interconnection as well as their connection with foreign PKI domains. The model was extended with the Validation Authority that provides more efficient processing of the certification path. / Применение электронного сервиса, использующего цифровые сертификаты увеличивается с каждым днем, увеличивается также и количество внедренных инфраструктур открытых ключей, в связи с чем появилось необходимость в их объединении и взаимодействии. В данной статье представлены результаты проведенного анализа модели взаимодействия между различными доменами инфраструктуры открытых ключей и возможность их применения в осуществлении взаимодействия инфраструктур открытых ключей в Республике

  9. Conferences on Combinatorial and Additive Number Theory

    CERN Document Server

    2014-01-01

    This proceedings volume is based on papers presented at the Workshops on Combinatorial and Additive Number Theory (CANT), which were held at the Graduate Center of the City University of New York in 2011 and 2012. The goal of the workshops is to survey recent progress in combinatorial number theory and related parts of mathematics. The workshop attracts researchers and students who discuss the state-of-the-art, open problems, and future challenges in number theory.

  10. 10 workshops on Immunology of preeclampsia.

    Science.gov (United States)

    Gerard, Chaouat

    2017-09-01

    For the 10th issue of the « island workshops », now the Reunion Workshops, organised by Pierre Yves Robillard since the first one in Tahiti challenging the "vascular disease only" theory of pre eclampsia and introducing the primipaternity concept, we examined the reasons for considering an Immunological approach to the disease. This (brief) overview thus examines several important topics in an Immunological framework. I have chosen to present here the evolution of the main themes rather than a purely chronological vision. Copyright © 2017. Published by Elsevier B.V.

  11. Workshop of medical physics

    International Nuclear Information System (INIS)

    1988-01-01

    This event was held in San Carlos de Bariloche, Argentine Republic from 14 th. through 18 th. November, 1988. A great part of the physicians in the area of medical physics participated in this workshop. This volume includes the papers presented at this Workshop of Medical Physics [es

  12. Workshops on Writing Science

    Indian Academy of Sciences (India)

    2017-09-30

    Sep 30, 2017 ... hands-on practice, feedback, mentoring and highly interactive sessions. The focus will be on work done as individuals and in teams. Maximum number of participants for the workshop is limited. The workshop is compulso- rily residential. Boarding and lodging free for selected candidates. Re-imbursement ...

  13. Warehouse Sanitation Workshop Handbook.

    Science.gov (United States)

    Food and Drug Administration (DHHS/PHS), Washington, DC.

    This workshop handbook contains information and reference materials on proper food warehouse sanitation. The materials have been used at Food and Drug Administration (FDA) food warehouse sanitation workshops, and are selected by the FDA for use by food warehouse operators and for training warehouse sanitation employees. The handbook is divided…

  14. SPLASH'13 workshops summary

    DEFF Research Database (Denmark)

    Balzer, S.; Schultz, U. P.

    2013-01-01

    Following its long-standing tradition, SPLASH 2013 will host 19 high-quality workshops, allowing their participants to meet and discuss research questions with peers, to mature new and exciting ideas, and to build up communities and start new collaborations. SPLASH workshops complement the main t...

  15. São Carlos Workshop on Real and Complex Singularities

    CERN Document Server

    Ruas, Maria

    2007-01-01

    The São Carlos Workshop on Real and Complex Singularities is the longest running workshop in singularities. It is held every two years and is a key international event for people working in the field. This volume contains papers presented at the eighth workshop, held at the IML, Marseille, July 19–23, 2004. The workshop offers the opportunity to establish the state of the art and to present new trends, new ideas and new results in all of the branches of singularities. This is reflected by the contributions in this book. The main topics discussed are equisingularity of sets and mappings, geometry of singular complex analytic sets, singularities of mappings, characteristic classes, classification of singularities, interaction of singularity theory with some of the new ideas in algebraic geometry imported from theoretical physics, and applications of singularity theory to geometry of surfaces in low dimensional euclidean spaces, to differential equations and to bifurcation theory.

  16. An assessment of PKI and networked electronic patient record system: lessons learned from real patient data exchange at the platform of OCHIS (Osaka Community Healthcare Information System).

    Science.gov (United States)

    Takeda, Hiroshi; Matsumura, Yasushi; Kuwata, Shigeki; Nakano, Hirohiko; Shanmai, Ji; Qiyan, Zhang; Yufen, Chen; Kusuoka, Hideo; Matsuoka, Masaki

    2004-03-31

    To enhance medical cooperation between the hospitals and clinics around Osaka local area, the healthcare network system, named Osaka Community Healthcare Information System (OCHIS), was established with support of a supplementary budget from the Japanese government in fiscal year 2002. Although the system has been based on healthcare public key infrastructure (PKI), there remain security issues to be solved technically and operationally. An experimental study was conducted to elucidate the central and the local function in terms of a registration authority and a time stamp authority in contract with the Japanese Medical Information Systems Organization (MEDIS) in 2003. This paper describes the experimental design and the results of the study concerning message security.

  17. Voluntary simulation workshops in nursing education

    DEFF Research Database (Denmark)

    Selberg, Hanne; Nielsen, Mette Elisabeth

    -10) was conducted immediately after the workshops with the purpose of evaluating students` self-perception of learning outcomes. Furthermore, the questionnaires included open ended qualitative questions with a formative design aiming at students´ judgment of the content and set up of the simulation workshops...... Results 97 students (response rate 82,2%) assessed their theoretical outcome on a 10 point scale with a mean score of 7,55 (SD 1,96), practical skills outcome mean 8,07 (SD 1,96), integration of theory and practice mean 8,27 (SD 1,62), general outcome mean 8,36 (SD 1,57) and outcome from simulation...... with more theory and less practical training have resulted in discussions regarding the lack of practical skills amongst novice nurses. A Danish study of students’ drop-out from the nursing education indicates that difficulties in combining theory and practice are one of the motivating factors behind...

  18. ASCR Workshop on Quantum Computing for Science

    Energy Technology Data Exchange (ETDEWEB)

    Aspuru-Guzik, Alan [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Van Dam, Wim [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Farhi, Edward [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gaitan, Frank [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Humble, Travis [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jordan, Stephen [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Landahl, Andrew J [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Love, Peter [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lucas, Robert [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Preskill, John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Muller, Richard P. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Svore, Krysta [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Wiebe, Nathan [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Williams, Carl [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-06-01

    This report details the findings of the DOE ASCR Workshop on Quantum Computing for Science that was organized to assess the viability of quantum computing technologies to meet the computational requirements of the DOE’s science and energy mission, and to identify the potential impact of quantum technologies. The workshop was held on February 17-18, 2015, in Bethesda, MD, to solicit input from members of the quantum computing community. The workshop considered models of quantum computation and programming environments, physical science applications relevant to DOE's science mission as well as quantum simulation, and applied mathematics topics including potential quantum algorithms for linear algebra, graph theory, and machine learning. This report summarizes these perspectives into an outlook on the opportunities for quantum computing to impact problems relevant to the DOE’s mission as well as the additional research required to bring quantum computing to the point where it can have such impact.

  19. Workshop on wave-ice interaction

    Science.gov (United States)

    Wadhams, Peter; Squire, Vernon; Rottier, Philip; Liu, Antony; Dugan, John; Czipott, Peter; Shen, Hayley

    The subject of wave-ice interaction has been advanced in recent years by small groups of researchers working on a similar range of topics in widely separated geographic locations. Their recent studies inspired a workshop on wave-ice interaction held at the Scott Polar Research Institute, University of Cambridge, England, December 16-18, 1991, where theories in all aspects of the physics of wave-ice interaction were compared.Conveners of the workshop hoped that plans for future observational and theoretical work dealing with outstanding issues in a collaborative way would emerge. The workshop, organized by the Commission on Sea Ice of the International Association for Physical Sciences of the Ocean (IAPSO), was co-chaired by Vernon Squire, professor of mathematics and statistics at the University of Otago, New Zealand, and Peter Wadhams, director of the Scott Polar Research Institute. Participants attended from Britain, Finland, New Zealand, Norway, and the United States.

  20. PV radiometrics workshop proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Myers, D.R.

    1995-09-01

    This report documents presentations and discussions held at the Photovoltaics Radiometeric Measurements Workshop conducted at Vail, Colorado, on July 24 and 25, 1995. The workshop was sponsored and financed by the Photovoltaic Module and Systems Performance and Engineering Project managed by Richard DeBlasio, Principal Investigator. That project is a component of the National Renewable Energy Laboratory (NREL) Photovoltaic Research and Development Program, conducted by NREL for the US Department of Energy, through the NREL Photovoltaic Engineering and Applications Branch, managed by Roland Hulstrom. Separate abstracts have been prepared for articles from this workshop.

  1. Nuclear Innovation Workshops Report

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, John Howard [Idaho National Lab. (INL), Idaho Falls, ID (United States); Allen, Todd Randall [Idaho National Lab. (INL), Idaho Falls, ID (United States); Hildebrandt, Philip Clay [Idaho National Lab. (INL), Idaho Falls, ID (United States); Baker, Suzanne Hobbs [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-09-01

    The Nuclear Innovation Workshops were held at six locations across the United States on March 3-5, 2015. The data collected during these workshops has been analyzed and sorted to bring out consistent themes toward enhancing innovation in nuclear energy. These themes include development of a test bed and demonstration platform, improved regulatory processes, improved communications, and increased public-private partnerships. This report contains a discussion of the workshops and resulting themes. Actionable steps are suggested at the end of the report. This revision has a small amount of the data in Appendix C removed in order to avoid potential confusion.

  2. Increased expression of protein kinase A inhibitor alpha (PKI-alpha) and decreased PKA-regulated genes in chronic intermittent alcohol exposure.

    Science.gov (United States)

    Repunte-Canonigo, Vez; Lutjens, Robert; van der Stap, Lena D; Sanna, Pietro Paolo

    2007-03-23

    Intermittent models of alcohol exposure that mimic human patterns of alcohol consumption produce profound physiological and biochemical changes and induce rapid increases in alcohol self-administration. We used high-density oligonucleotide microarrays to investigate gene expression changes during chronic intermittent alcohol exposure in three brain regions that receive mesocorticolimbic dopaminergic projections and that are believed to be involved in alcohol's reinforcing actions: the medial prefrontal cortex, the nucleus accumbens and the amygdala. An independent replication of the experiment was used for RT-PCR validation of the microarray results. The protein kinase A inhibitor alpha (PKI-alpha, Pkia), a member of the endogenous PKI family implicated in reducing nuclear PKA activity, was found to be increased in all three regions tested. Conversely, we observed a downregulation of the expression of several PKA-regulated transcripts in one or more of the brain regions studied, including the activity and neurotransmitter-regulated early gene (Ania) - 1, -3, -7, -8, the transcription factors Egr1 and NGFI-B (Nr4a1) and the neuropeptide NPY. Reduced expression of PKA-regulated genes in mesocorticolimbic projection areas may have motivational significance in the rapid increase in alcohol self-administration induced by intermittent alcohol exposure.

  3. WORKSHOPS: Radiofrequency superconductivity

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    In the continual push towards higher energy particle beams, superconducting radiofrequency techniques now play a vital role, highlighted in the fifth workshop on radiofrequency superconductivity, held at DESY from 19 - 24 August 1991

  4. Transportation Management Workshop: Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    1993-10-01

    This report is a compilation of discussions presented at the Transportation Management Workshop held in Gaithersburg, Maryland. Topics include waste packaging, personnel training, robotics, transportation routing, certification, containers, and waste classification.

  5. WORKSHOPS: Radiofrequency superconductivity

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1992-01-15

    In the continual push towards higher energy particle beams, superconducting radiofrequency techniques now play a vital role, highlighted in the fifth workshop on radiofrequency superconductivity, held at DESY from 19 - 24 August 1991.

  6. GammaWorkshops Proceedings

    DEFF Research Database (Denmark)

    Strålberg, Elisabeth; Klemola, Seppo; Nielsen, Sven Poul

    to the GammaWorkshops. The topics included efficiency transfer, true coincidence summing corrections, self-attenuation corrections, measurement of natural radionuclides (natural decay series), combined measurement uncertainty calculations, and detection limits. These topics covered both lectures and practical...

  7. YEREVAN: Acceleration workshop

    International Nuclear Information System (INIS)

    Anon.

    1989-01-01

    Sponsored by the Yerevan Physics Institute in Armenia, a Workshop on New Methods of Charged Particle Acceleration in October near the Nor Amberd Cosmic Ray Station attracted participants from most major accelerator centres in the USSR and further afield

  8. Cybernetics and Workshop Design.

    Science.gov (United States)

    Eckstein, Daniel G.

    1979-01-01

    Cybernetic sessions allow for the investigation of several variables concurrently, resulting in a large volume of input compacted into a concise time frame. Three session questions are reproduced to illustrate the variety of ideas generated relative to workshop design. (Author)

  9. Transportation Management Workshop: Proceedings

    International Nuclear Information System (INIS)

    1993-01-01

    This report is a compilation of discussions presented at the Transportation Management Workshop held in Gaithersburg, Maryland. Topics include waste packaging, personnel training, robotics, transportation routing, certification, containers, and waste classification

  10. Appalachian Stream Mitigation Workshop

    Science.gov (United States)

    A 5 day workshop in 2011 developed for state and federal regulatory and resource agencies, who review, comment on and/or approve compensatory mitigation plans for surface coal mining projects in Appalachia

  11. Complex Flow Workshop Report

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2012-05-01

    This report documents findings from a workshop on the impacts of complex wind flows in and out of wind turbine environments, the research needs, and the challenges of meteorological and engineering modeling at regional, wind plant, and wind turbine scales.

  12. Second ICFA workshop

    International Nuclear Information System (INIS)

    Anon.

    1979-01-01

    A summary is given of the topics discussed at the second ICFA Workshop on 'Possibilities and Limitations of Accelerators and Detectors'. High energy accelerators are discussed, particularly electron-positron and proton-antiproton colliders. (W.D.L.).

  13. Workshop I: Gender Studies

    Science.gov (United States)

    Hennessey, Eden; Kurup, Anitha; Meza-Montes, Lilia; Shastri, Prajval; Ghose, Shohini

    2015-12-01

    Participants in the Gender Studies workshop of the 5th IUPAP International Conference on Women in Physics discussed the gender question in science practice from a policy perspective, informed by investigations from the social science disciplines. The workshop's three sessions—"Equity and Education: Examining Gender Stigma in Science," "A Comparative Study of Women Scientists and Engineers: Experiences in India and the US," and "Toward Gender Equity Through Policy: Characterizing the Social Impact of Interventions—are summarized, and the resulting recommendations presented.

  14. TPC workshop summary

    International Nuclear Information System (INIS)

    Nygren, D.R.

    1984-01-01

    The Time Projection Chamber (TPC) concept is now nearly ten years old and, as is evident in this workshop, is still evolving in many directions. From the liquid xenon TPC for double beta decay studies to the impressively large second generation TPC for the LEP experiment ALEPH, the surprising diversity of current applications is apparent. This workshop, the first to concentrate solely on the TPC has provided a most congenial and rewarding occasion for all TPC enthusiasts to share experience, results, and ideas

  15. Industrial Fuel Flexibility Workshop

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2006-09-01

    On September 28, 2006, in Washington, DC, ITP and Booz Allen Hamilton conducted a fuel flexibility workshop with attendance from various stakeholder groups. Workshop participants included representatives from the petrochemical, refining, food and beverage, steel and metals, pulp and paper, cement and glass manufacturing industries; as well as representatives from industrial boiler manufacturers, technology providers, energy and waste service providers, the federal government and national laboratories, and developers and financiers.

  16. Proceeding of the workshop on quantum gravity and topology

    International Nuclear Information System (INIS)

    Oda, Ichiro

    1991-10-01

    The workshop on Quantum Gravity and Topology was held at INS on February 21-23, 1991. Several introductory lectures and more than 15 talks were delivered for about 100 participants. The main subjects discussed were i) Topological quantum field theories and topological gravity ii) Low dimensional and four dimensional gravity iii) Topology change iv) Superstring theories etc. (J.P.N.)

  17. Proceeding of the 5th international workshop on reflectometry

    International Nuclear Information System (INIS)

    Kawahata, Kazuo

    2001-05-01

    This is the proceedings of the 5th International Workshop on Reflectometry, which was held on 5-7 March, 2001, at the National Institute for Fusion Science. In this workshop, the latest experimental results in reflectometry (profile and fluctuations studies), new technological developments and a broad scope of the theory and simulation codes were presented. The 19 of the presented papers are indexed individually. (author)

  18. Third International Workshop on Squeezed States and Uncertainty Relations

    Science.gov (United States)

    Han, D. (Editor); Kim, Y. S. (Editor); Rubin, Morton H. (Editor); Shih, Yan-Hua (Editor); Zachary, Woodford W. (Editor)

    1994-01-01

    The purpose of these workshops is to bring together an international selection of scientists to discuss the latest developments in Squeezed States in various branches of physics, and in the understanding of the foundations of quantum mechanics. At the third workshop, special attention was given to the influence that quantum optics is having on our understanding of quantum measurement theory. The fourth meeting in this series will be held in the People's Republic of China.

  19. XX International Workshop on Condensed Matter Theories

    Science.gov (United States)

    1998-01-01

    Rojo5, M.A. Solis6 and A.A. Valladares4 1 Institute de Fisica Teorica-UNESP, 01405 Säo Paulo, BRAZIL and Departamento de Fisica , Universidade...Estadual de Londrina Londrina, PR, BRAZIL 2Departament de Fisica , Universität de les Hies Balears 07071 Palma de Mallorca, SPAIN department of Physics...SUNY, Buffalo, NY 14260-1500, USA 4Instituto de Investigaciones en Materiales, UN AM 04510 Mexico DF, MEXICO 5PESTIC, Secretaria Academica, IPN

  20. DESY: HERA superconducting magnets OK; Theory workshop

    International Nuclear Information System (INIS)

    Anon.

    1990-01-01

    The HERA electron-proton collider being built at the DESY Laboratory in Hamburg is the first accelerator using superconducting magnets manufactured by industry on a large scale. For this pioneering step several potential problems now seem to be all well under control, with important contributions coming from both the manufacturers and DESY's accelerator specialists

  1. National Workshop on Coding Theory and Cryptography

    Indian Academy of Sciences (India)

    commerce and other interdisciplinary aspects of the theme. Participants. Research scholars/teachers from Academic Institutions and those from Software Development. Centres, National Laboratories and other Research and Development ...

  2. The QED Workshop

    Energy Technology Data Exchange (ETDEWEB)

    Pieper, G.W.

    1994-07-01

    On May 18--20, 1994, Argonne National Laboratory hosted the QED Workshop. The workshop was supported by special funding from the Office of Naval Research. The purpose of the workshop was to assemble of a group of researchers to consider whether it is desirable and feasible to build a proof-checked encyclopedia of mathematics, with an associated facility for theorem proving and proof checking. Among the projects represented were Coq, Eves, HOL, ILF, Imps, MathPert, Mizar, NQTHM, NuPrl, OTTER, Proof Pad, Qu-Prolog, and RRL. Although the content of the QED project is highly technical rigorously proof-checked mathematics of all sorts the discussions at the workshop were rarely technical. No prepared talks or papers were given. Instead, the discussions focused primarily on such political, sociological, practical, and aesthetic questions, such as Why do it? Who are the customers? How can one get mathematicians interested? What sort of interfaces are desirable? The most important conclusion of the workshop was that QED is an idea worthy pursuing, a statement with which virtually all the participants agreed. In this document, the authors capture some of the discussions and outline suggestions for the start of a QED scientific community.

  3. t4 Workshop Report*

    Science.gov (United States)

    Kleensang, Andre; Maertens, Alexandra; Rosenberg, Michael; Fitzpatrick, Suzanne; Lamb, Justin; Auerbach, Scott; Brennan, Richard; Crofton, Kevin M.; Gordon, Ben; Fornace, Albert J.; Gaido, Kevin; Gerhold, David; Haw, Robin; Henney, Adriano; Ma’ayan, Avi; McBride, Mary; Monti, Stefano; Ochs, Michael F.; Pandey, Akhilesh; Sharan, Roded; Stierum, Rob; Tugendreich, Stuart; Willett, Catherine; Wittwehr, Clemens; Xia, Jianguo; Patton, Geoffrey W.; Arvidson, Kirk; Bouhifd, Mounir; Hogberg, Helena T.; Luechtefeld, Thomas; Smirnova, Lena; Zhao, Liang; Adeleye, Yeyejide; Kanehisa, Minoru; Carmichael, Paul; Andersen, Melvin E.; Hartung, Thomas

    2014-01-01

    Summary Despite wide-spread consensus on the need to transform toxicology and risk assessment in order to keep pace with technological and computational changes that have revolutionized the life sciences, there remains much work to be done to achieve the vision of toxicology based on a mechanistic foundation. A workshop was organized to explore one key aspect of this transformation – the development of Pathways of Toxicity (PoT) as a key tool for hazard identification based on systems biology. Several issues were discussed in depth in the workshop: The first was the challenge of formally defining the concept of a PoT as distinct from, but complementary to, other toxicological pathway concepts such as mode of action (MoA). The workshop came up with a preliminary definition of PoT as “A molecular definition of cellular processes shown to mediate adverse outcomes of toxicants”. It is further recognized that normal physiological pathways exist that maintain homeostasis and these, sufficiently perturbed, can become PoT. Second, the workshop sought to define the adequate public and commercial resources for PoT information, including data, visualization, analyses, tools, and use-cases, as well as the kinds of efforts that will be necessary to enable the creation of such a resource. Third, the workshop explored ways in which systems biology approaches could inform pathway annotation, and which resources are needed and available that can provide relevant PoT information to the diverse user communities. PMID:24127042

  4. Final Scientific EFNUDAT Workshop

    CERN Multimedia

    CERN. Geneva

    2010-01-01

    The Final Scientific EFNUDAT Workshop - organized by the CERN/EN-STI group on behalf of n_TOF Collaboration - will be held at CERN, Geneva (Switzerland) from 30 August to 2 September 2010 inclusive.EFNUDAT website: http://www.efnudat.euTopics of interest include: Data evaluationCross section measurementsExperimental techniquesUncertainties and covariancesFission propertiesCurrent and future facilities  International Advisory Committee: C. Barreau (CENBG, France)T. Belgya (IKI KFKI, Hungary)E. Gonzalez (CIEMAT, Spain)F. Gunsing (CEA, France)F.-J. Hambsch (IRMM, Belgium)A. Junghans (FZD, Germany)R. Nolte (PTB, Germany)S. Pomp (TSL UU, Sweden) Workshop Organizing Committee: Enrico Chiaveri (Chairman)Marco CalvianiSamuel AndriamonjeEric BerthoumieuxCarlos GuerreroRoberto LositoVasilis Vlachoudis Workshop Assistant: Géraldine Jean

  5. WALLTURB International Workshop

    CERN Document Server

    Jimenez, Javier; Marusic, Ivan

    2011-01-01

    This book brings together selected contributions from the WALLTURB workshop on ”Understanding and modelling of wall turbulence” held in Lille, France, on April 21st to 23rd 2009. This workshop was organized by the WALLTURB consortium, in order to present to the relevant scientific community the main results of the project and to stimulate scientific discussions around the subject of wall turbulence. The workshop reviewed the recent progress in theoretical, experimental and numerical approaches to wall turbulence. The problems of zero pressure gradient, adverse pressure gradient and separating turbulent boundary layers were addressed in detail with the three approaches, using the most advanced tools. This book is a milestone in the research field, thanks to the high level of the invited speakers and the involvement of the contributors and a testimony of the achievement of the WALLTURB project.

  6. Vulcano Workshop 2016

    CERN Document Server

    Mannocchi, G.; Morselli, A.; Trinchero, G.

    2016-01-01

    We announce the XVI Vulcano Workshop, which will be held from May 22nd to May 28th, 2016 in the Vulcano Island (Sicily, Italy). As in the past editions, the workshop will aim to gather people from High Energy Astrophysics and Particle Physics to discuss the most recent highlights in these fields. The workshop will cover the following topics: Astrophysics/Cosmology, Astrophysics/Gravity, Dark Matter, Particle Physics, Cosmic Rays, Gamma/Neutrino Astronomy, Neutrinos and Future Prospects. The scientific program will include several 30-minute review talks, to introduce the current problems, and 20-minute talks, giving new experimental and theoretical results. The participation is by invitation and limited to 80 people.

  7. 7th International Workshop on Natural Computing

    CERN Document Server

    Hagiya, Masami

    2015-01-01

    This book highlights recent advances in natural computing, including biology and its theory, bio-inspired computing, computational aesthetics, computational models and theories, computing with natural media, philosophy of natural computing and educational technology. It presents extended versions of the best papers selected from the symposium “7th International Workshop on Natural Computing” (IWNC7), held in Tokyo, Japan, in 2013. The target audience is not limited to researchers working in natural computing but also those active in biological engineering, fine/media art design, aesthetics and philosophy.

  8. 8th International Workshop on Natural Computing

    CERN Document Server

    Hagiya, Masami

    2016-01-01

    This book highlights recent advances in natural computing, including biology and its theory, bio-inspired computing, computational aesthetics, computational models and theories, computing with natural media, philosophy of natural computing, and educational technology. It presents extended versions of the best papers selected from the “8th International Workshop on Natural Computing” (IWNC8), a symposium held in Hiroshima, Japan, in 2014. The target audience is not limited to researchers working in natural computing but also includes those active in biological engineering, fine/media art design, aesthetics, and philosophy.

  9. Measurement control workshop instructional materials

    Energy Technology Data Exchange (ETDEWEB)

    Gibbs, Philip [Brookhaven National Lab. (BNL), Upton, NY (United States); Crawford, Cary [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); McGinnis, Brent [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Insolves LLC, Piketon, OH (United States)

    2014-04-01

    A workshop to teach the essential elements of an effective nuclear materials control and accountability (MC&A) programs are outlined, along with the modes of Instruction, and the roles and responsibilities of participants in the workshop.

  10. Measurement Control Workshop Instructional Materials

    International Nuclear Information System (INIS)

    Gibbs, Philip; Crawford, Cary; McGinnis, Brent

    2014-01-01

    A workshop to teach the essential elements of an effective nuclear materials control and accountability (MC&A) programs are outlined, along with the modes of Instruction, and the roles and responsibilities of participants in the workshop.

  11. The Astronomy Workshop

    Science.gov (United States)

    Hamilton, D. P.; Asbury, M. L.; Proctor, A.

    2001-12-01

    The Astronomy Workshop (http://janus.astro.umd.edu) is an interactive online astronomy resource developed, and maintained at the University of Maryland, for use by students, educators and the general public. The Astronomy Workshop has been extensively tested and used successfully at many different levels, including High School and Junior High School science classes, University introductory astronomy courses, and University intermediate and advanced astronomy courses. Some topics currently covered in the Astronomy Workshop are: Animated Orbits of Planets and Moons: The orbits of the nine planets and 91 known planetary satellites are shown in animated, to-scale drawings. The orbiting bodies move at their correct relative speeds about their parent, which is rendered as an attractive, to-scale gif image. Solar System Collisions: This most popular of our applications shows what happens when an asteroid or comet with user-defined size and speed impacts a given planet. The program calculates many effects, including the country impacted (if Earth is the target), energy of the explosion, crater size, magnitude of the planetquake generated. It also displays a relevant image (e.g. terrestrial crater, lunar crater, etc.). Planetary and Satellite Data Calculators: These tools allow the user to easily calculate physical data for all of the planets or satellites simultaneously, making comparison very easy. Orbital Simulations: These tools allow the student to investigate different aspects of the three-body problem of celestial mechanics. Astronomy Workshop Bulletin Board: Get innovative teaching ideas and read about in-class experiences with the Astronomy Workshop. Share your ideas with other educators by posting on the Bulletin Board. Funding for the Astronomy Workshop is provided by the National Science Foundation.

  12. Factors enhancing learning possibilities in digital workshops

    Directory of Open Access Journals (Sweden)

    Christian Kobbernagel

    2014-05-01

    Full Text Available This article presents a study of processes supporting student learning possibilities in digital workshops planned and held at art museums in Denmark. The investigation aims to provide insights into factors enhancing learning possibilities, including the educator’s dialogic performance, experiences of art, and perceived qualities of digital content creation processes in art museum education workshops. To address the research question of what conditional and processual factors can be said to support learning possibilities, a model was developed on the basis of fieldwork and theories of media education, art pedagogy and motivation. The model was then analyzed using structural equation modelling (SEM on data collected (N= 502 after workshops in two museums. The results suggest that the dialogic performance of museum educators, a positive art experience and positive perceptions of working with digital media are factors that strongly support student participation and reflection – although to various degrees. The findings also show that, in cases in which students are disinterested and see little value in participating during the workshop, this amotivation is likely to be lower when their art experiences and their perceptions of the media production process are positive. 

  13. Factors enhancing learning possibilities in digital workshops

    Directory of Open Access Journals (Sweden)

    Christian Kobbernagel

    2014-06-01

    Full Text Available This article presents a study of processes supporting student learning possibilities in digital workshops planned and held at art museums in Denmark. The investigation aims to provide insights into factors enhancing learning possibilities, including the educator’s dialogic performance, experiences of art, and perceived qualities of digital content creation processes in art museum education workshops. To address the research question of what conditional and processual factors can be said to support learning possibilities, a model was developed on the basis of fieldwork and theories of media education, art pedagogy and motivation. The model was then analyzed using structural equation modelling (SEM on data collected (N= 502 after workshops in two museums. The results suggest that the dialogic performance of museum educators, a positive art experience and positive perceptions of working with digital media are factors that strongly support student participation and reflection – although to various degrees. The findings also show that, in cases in which students are disinterested and see little value in participating during the workshop, this amotivation is likely to be lower when their art experiences and their perceptions of the media production process are positive.

  14. Diagnostic Imaging Workshop

    International Nuclear Information System (INIS)

    Sociedad Argentina de Fisica Medica

    2012-01-01

    The American Association of Physicist in Medicine (AAPM), the International Organization for Medical Physics (IOMP) and the Argentina Society of Medical Physics (SAFIM) was organized the Diagnostic Imaging Workshop 2012, in the city of Buenos Aires, Argentina. This workshop was an oriented training and scientific exchange between professionals and technicians who work in medical physics, especially in the areas of diagnostic imaging, nuclear medicine and radiotherapy, with special emphasis on the use of multimodal imaging for radiation treatment, planning as well of quality assurance associates.

  15. Magnetic Suspension Technology Workshop

    International Nuclear Information System (INIS)

    Keckler, C.R.; Groom, N.J.; Britcher, C.P.

    1993-01-01

    In order to identify the state of magnetic suspension technology in such areas as rotating systems, pointing of experiments or subsystems, payload isolation, and superconducting materials, a workshop on Magnetic Suspension Technology was held at the Langley Research Center in Hampton, Virginia, on 2-4 Feb. 1988. The workshop included five technical sessions in which a total of 24 papers were presented. The technical sessions covered the areas of pointing, isolation, and measurement, rotating systems, modeling and control, and superconductors. A list of attendees is provided. Separate abstracts have been prepared for articles from this report

  16. Lead optimization of N-3-substituted 7-morpholinotriazolopyrimidines as dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors: discovery of PKI-402.

    Science.gov (United States)

    Dehnhardt, Christoph M; Venkatesan, Aranapakam M; Delos Santos, Efren; Chen, Zecheng; Santos, Osvaldo; Ayral-Kaloustian, Semiramis; Brooijmans, Natasja; Mallon, Robert; Hollander, Irwin; Feldberg, Larry; Lucas, Judy; Chaudhary, Inder; Yu, Ker; Gibbons, Jay; Abraham, Robert; Mansour, Tarek S

    2010-01-28

    Herein we describe the identification and lead optimization of triazolopyrimidines as a novel class of potent dual PI3K/mTOR inhibitors, resulting in the discovery of 3 (PKI-402). Compound 3 exhibits good physical properties and PK parameters, low nanomolar potency against PI3Kalpha and mTOR, and excellent inhibition of cell proliferation in several human cancer cell lines. Furthermore, in vitro and in vivo biomarker studies demonstrated the ability of 3 to shut down the PI3K/Akt pathway and induce apoptosis in cancer cells. In addition, 3 showed excellent in vivo efficacy in various human cancer xenografts, validating suppression of PI3K/mTOR signaling as a potential anticancer therapy.

  17. Proceedings International Workshop on Formal Engineering approaches to Software Components and Architectures

    OpenAIRE

    Kofroň, Jan; Tumova, Jana

    2017-01-01

    These are the proceedings of the 14th International Workshop on Formal Engineering approaches to Software Components and Architectures (FESCA). The workshop was held on April 22, 2017 in Uppsala (Sweden) as a satellite event to the European Joint Conference on Theory and Practice of Software (ETAPS'17). The aim of the FESCA workshop is to bring together junior researchers from formal methods, software engineering, and industry interested in the development and application of formal modelling ...

  18. Proceedings 10th International Workshop on Formal Engineering Approaches to Software Components and Architectures

    OpenAIRE

    Buhnova, Barbora; Happe, Lucia; Kofroň, Jan

    2013-01-01

    These are the proceedings of the 10th International Workshop on Formal Engineering approaches to Software Components and Architectures (FESCA). The workshop was held on March 23, 2013 in Rome (Italy) as a satellite event to the European Joint Conference on Theory and Practice of Software (ETAPS'13). The aim of the FESCA workshop is to bring together both young and senior researchers from formal methods, software engineering, and industry interested in the development and application of formal...

  19. Plasmids encoding PKI(1-31), a specific inhibitor of cAMP-stimulated gene expression, inhibit the basal transcriptional activity of some but not all cAMP-regulated DNA response elements in JEG-3 cells.

    Science.gov (United States)

    Grove, J R; Deutsch, P J; Price, D J; Habener, J F; Avruch, J

    1989-11-25

    Plasmids that encode a bioactive amino-terminal fragment of the heat-stable inhibitor of the cAMP-dependent protein kinase, PKI(1-31), were employed to characterize the role of this protein kinase in the control of transcriptional activity mediated by three DNA regulatory elements in the JEG-3 human placental cell line. The 5'-flanking sequence of the human collagenase gene contains the heptameric sequence, 5'-TGAGTCA-3', previously identified as a "phorbol ester" response element. Reporter genes containing either the intact 1.2-kilobase 5'-flanking sequence from the human collagenase gene or just the 7-base pair (bp) response element, when coupled to an enhancerless promoter, each exhibit both cAMP and phorbol ester-stimulated expression in JEG-3 cells. Cotransfection of either construct with plasmids encoding PKI(1-31) inhibits cAMP-stimulated but not basal- or phorbol ester-stimulated expression. Pretreatment of cells with phorbol ester for 1 or 2 days abrogates completely the response to rechallenge with phorbol ester but does not alter the basal expression of either construct; cAMP-stimulated expression, while modestly inhibited, remains vigorous. The 5'-flanking sequence of the human chorionic gonadotropin-alpha subunit (HCG alpha) gene has two copies of the sequence, 5'-TGACGTCA-3', contained in directly adjacent identical 18-bp segments, previously identified as a cAMP-response element. Reporter genes containing either the intact 1.5 kilobase of 5'-flanking sequence from the HCG alpha gene, or just the 36-bp tandem repeat cAMP response element, when coupled to an enhancerless promoter, both exhibit a vigorous cAMP stimulation of expression but no response to phorbol ester in JEG-3 cells. Cotransfection with plasmids encoding PKI(1-31) inhibits both basal and cAMP-stimulated expression in a parallel fashion. The 5'-flanking sequence of the human enkephalin gene mediates cAMP-stimulated expression of reporter genes in both JEG-3 and CV-1 cells. Plasmids

  20. The PKI collector

    Science.gov (United States)

    Rice, M. P.

    1982-07-01

    The design and manufacturing of a solar thermal collector is discussed. The collector has three primary subsystems: concentrator, receiver/fluid loop, and controls. Identical curved reflective columns are utilized in a faceted Fresnel design to support 864 one foot square flat inexpensive second-surface, silvered glass mirrors. The columns are ganged together and rotated through their centers of gravity to provide elevation tracking. The concentrator is supported by a lightweight spaceframe structure which distributes all wind and gravity loads to the base supports. The base of the structure is a track which rotates on wheels mounted on concrete piers. A parallel tube steel heat exchanger is mounted at the concentrator focal area in a well insulated, galvanized steel housing. Two rows of vertical close-packed, staggered tubes connect a mud header and a steam header. Automatic two axis tracking and operational control is provided with a microprocessor based package. Concentrator-mounted shadowbands are the basis for active tracking. A software program provides azimuthal tracking during cloudy periods.

  1. PKI als veilig communicatiemiddel

    NARCIS (Netherlands)

    Spek, J. van der; Veugen, P.J.M.

    2002-01-01

    Het belang van betrouwbare elektronische communicatie neemt hand over hand toe. Niet alleen in de context van gesloten oplossingen in bedrijfsleven of overheid, maar in toenemende mate ook in open omgevingen tussen partijen die niet van tevoren contractueel met elkaar zijn verbonden. Belangrijke

  2. 2nd workshop on Heavy Flavour Production at the LHC

    CERN Document Server

    2017-01-01

    The second HF@LHC workshop for experimenters and theorists to discuss successes and failures in measurement and simulation of heavy quark production at the LHC and relevant aspects of their decays. The workshop will bring together experts in areas of LHC physics sensitive to top, bottom, and charm quark production, from both the theory and experimental communities. Focus will be placed on areas where new experimental data is needed as modelling input, and where experimental studies are currently limited by theory uncertainties. Lively discussion is strongly encouraged!

  3. Summary of cosmology workshop

    Indian Academy of Sciences (India)

    in quality, quantity, and the scope of cosmological observations. While the ob- ... In this article, I summarize both the oral and poster presentations made at the workshop. ... the angular spectrum of CMB anisotropy with recent measurements of the power spectrum of ..... A thermodynamical treatment within the framework of.

  4. Radiation Source Replacement Workshop

    Energy Technology Data Exchange (ETDEWEB)

    Griffin, Jeffrey W.; Moran, Traci L.; Bond, Leonard J.

    2010-12-01

    This report summarizes a Radiation Source Replacement Workshop in Houston Texas on October 27-28, 2010, which provided a forum for industry and researchers to exchange information and to discuss the issues relating to replacement of AmBe, and potentially other isotope sources used in well logging.

  5. Flywheel energy storage workshop

    Energy Technology Data Exchange (ETDEWEB)

    O`Kain, D.; Carmack, J. [comps.

    1995-12-31

    Since the November 1993 Flywheel Workshop, there has been a major surge of interest in Flywheel Energy Storage. Numerous flywheel programs have been funded by the Advanced Research Projects Agency (ARPA), by the Department of Energy (DOE) through the Hybrid Vehicle Program, and by private investment. Several new prototype systems have been built and are being tested. The operational performance characteristics of flywheel energy storage are being recognized as attractive for a number of potential applications. Programs are underway to develop flywheels for cars, buses, boats, trains, satellites, and for electric utility applications such as power quality, uninterruptible power supplies, and load leveling. With the tremendous amount of flywheel activity during the last two years, this workshop should again provide an excellent opportunity for presentation of new information. This workshop is jointly sponsored by ARPA and DOE to provide a review of the status of current flywheel programs and to provide a forum for presentation of new flywheel technology. Technology areas of interest include flywheel applications, flywheel systems, design, materials, fabrication, assembly, safety & containment, ball bearings, magnetic bearings, motor/generators, power electronics, mounting systems, test procedures, and systems integration. Information from the workshop will help guide ARPA & DOE planning for future flywheel programs. This document is comprised of detailed viewgraphs.

  6. WORKSHOP: Scintillating fibre detectors

    International Nuclear Information System (INIS)

    Anon.

    1989-01-01

    Scintillating fibre detector development and technology for the proposed US Superconducting Supercollider, SSC, was the subject of a recent workshop at Fermilab, with participation from the high energy physics community and from industry. Sessions covered the current status of fibre technology and fibre detectors, new detector applications, fluorescent materials and scintillation compositions, radiation damage effects, amplification and imaging structures, and scintillation fibre fabrication techniques

  7. WORKSHOP: Nuclear physics

    Energy Technology Data Exchange (ETDEWEB)

    Sheepard, Jim; Van Dyck, Olin

    1985-06-15

    A workshop 'Dirac Approaches t o Nuclear Physics' was held at Los Alamos from 31 January to 2 February, the first meeting ever on relativistic models of nuclear phenomena. The objective was to cover historical background as well as the most recent developments in the field, and communication between theorists and experimentalists was given a high priority.

  8. Second Quaternary dating workshop

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-11-01

    The second Quaternary dating methods workshop was held at Lucas Heights and sponsored by ANSTO and AINSE. Topics covered include, isotope and thermoluminescence dating, usage of accelerator and thermal ionisation mass spectrometry in environmental studies emphasizing on the methodologies used and sample preparation

  9. General conclusions on workshop

    International Nuclear Information System (INIS)

    Rustand, H.

    2006-01-01

    The author proposes a general conclusion on the second workshop on the indemnification of damage in the event of a nuclear accident, organized in Bratislava, the 18-20 May 2005. He pointed out the most important discussions and the results revealed during these two days. (A.L.B.)

  10. WORKSHOP: Scintillating crystals

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1992-12-15

    Scintillating crystals are one of the big spinoff success stories of particle physics, and from 22-26 September an international workshop in Chamonix in the French Alps looked at the increasing role of these materials in pure and applied science and in industry.

  11. ATLAS TRT 2002 Workshop

    CERN Multimedia

    Capeans, M.

    Starting on 17th May, the ATLAS TRT 2002 Workshop was organised by Ken MacFarlane and his team at Hampton University, Virginia, USA. During a welcome break in the very dense workshop programme, the group enjoyed a half-day long boat trip along the waterways, offering a first-hand look at the history and heritage of this part of America. The attendance during the six-day workshop was about 50 people representing most of the collaborating institutes, although many Russian colleagues had stayed in their institutes to pursue the start-up of end-cap wheel production at PNPI and DUBNA. The meeting clearly showed that, during the year 2002, the TRT community is focusing on final design issues and module/wheel construction, while moving at the same time towards acceptance testing and integration, including the front-end electronics. The two main topics treated at the workshop were the preparation for beginning full production of the FE electronics, and the wire-joint problem that the US barrel colleagues have been fa...

  12. WORKSHOP: Scintillating crystals

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    Scintillating crystals are one of the big spinoff success stories of particle physics, and from 22-26 September an international workshop in Chamonix in the French Alps looked at the increasing role of these materials in pure and applied science and in industry

  13. LINEAR COLLIDERS: 1992 workshop

    International Nuclear Information System (INIS)

    Settles, Ron; Coignet, Guy

    1992-01-01

    As work on designs for future electron-positron linear colliders pushes ahead at major Laboratories throughout the world in a major international collaboration framework, the LC92 workshop held in Garmisch Partenkirchen this summer, attended by 200 machine and particle physicists, provided a timely focus

  14. Conferences, workshops, trainings

    Science.gov (United States)

    Goals Recycling Green Purchasing Pollution Prevention Reusing Water Resources Environmental Management . Mar 1 Wed 8:00 AM Cosmic Rays, Pulsar Nebulae and Dark Matter La Fonda Hotel, Santa Fe, NM The purpose Quantum Matter La Fonda Hotel - 100 East San Francisco Street, Santa Fe, NM The purpose of this workshop

  15. YOUR house - workshop

    DEFF Research Database (Denmark)

    2013-01-01

    Exhibition shows the result of a three-week workshop for 3.year students from the Architecture school in which I wanted to test the idea that good architecture is a balanced work between the non-reflective life experience of space and materiality (all the things you know and feel subconsciously a...

  16. OpenShift Workshop

    CERN Multimedia

    CERN. Geneva; Rodriguez Peon, Alberto

    2017-01-01

    Workshop to introduce developers to the OpenShift platform available at CERN. Several use cases will be shown, including deploying an existing application into OpenShift. We expect attendees to realize about OpenShift features and general architecture of the service.

  17. DNA Microarray Workshop

    National Research Council Canada - National Science Library

    Lauro, Bernie

    1999-01-01

    .... Funding for the workshop was provided by the US Department of Defense (USAMRAA). The aim of the meeting was to discuss how to best use the data derived from the Malaria Genome Sequencing Project for the functional analysis of the genome...

  18. FINPIE/97. Workshop proceedings

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    This publication contains the proceedings of 1997 Finnish Workshop on Power and Industrial Electronics, held in Espoo, Finland, on 26 August, 1997. The programme consisted of technical sessions on Advanced AC Motor Control, Electric Machines and Drives, Advanced Control and Measurement, Power Electronics Systems, Modelling and Simulation, and Power Converters

  19. Second Quaternary dating workshop

    International Nuclear Information System (INIS)

    1999-01-01

    The second Quaternary dating methods workshop was held at Lucas Heights and sponsored by ANSTO and AINSE. Topics covered include, isotope and thermoluminescence dating, usage of accelerator and thermal ionisation mass spectrometry in environmental studies emphasizing on the methodologies used and sample preparation

  20. 8. stellarator workshop

    International Nuclear Information System (INIS)

    1991-07-01

    The technical reports in this collection of papers were presented at the 8th International Workshop on Stellarators, and International Atomic Energy Agency Technical Committee Meeting. They include presentations on transport, magnetic configurations, fluctuations, equilibrium, stability, edge plasma and wall aspects, heating, diagnostics, new concepts and reactor studies. Refs, figs and tabs

  1. Nuclear Physics Science Network Requirements Workshop, May 2008 - Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Tierney, Ed., Brian L; Dart, Ed., Eli; Carlson, Rich; Dattoria, Vince; Ernest, Michael; Hitchcock, Daniel; Johnston, William; Kowalski, Andy; Lauret, Jerome; Maguire, Charles; Olson, Douglas; Purschke, Martin; Rai, Gulshan; Watson, Chip; Vale, Carla

    2008-11-10

    The Energy Sciences Network (ESnet) is the primary provider of network connectivity for the US Department of Energy Office of Science, the single largest supporter of basic research in the physical sciences in the United States of America. In support of the Office of Science programs, ESnet regularly updates and refreshes its understanding of the networking requirements of the instruments, facilities, scientists, and science programs that it serves. This focus has helped ESnet to be a highly successful enabler of scientific discovery for over 20 years. In May 2008, ESnet and the Nuclear Physics (NP) Program Office of the DOE Office of Science organized a workshop to characterize the networking requirements of the science programs funded by the NP Program Office. Most of the key DOE sites for NP related work will require significant increases in network bandwidth in the 5 year time frame. This includes roughly 40 Gbps for BNL, and 20 Gbps for NERSC. Total transatlantic requirements are on the order of 40 Gbps, and transpacific requirements are on the order of 30 Gbps. Other key sites are Vanderbilt University and MIT, which will need on the order of 20 Gbps bandwidth to support data transfers for the CMS Heavy Ion program. In addition to bandwidth requirements, the workshop emphasized several points in regard to science process and collaboration. One key point is the heavy reliance on Grid tools and infrastructure (both PKI and tools such as GridFTP) by the NP community. The reliance on Grid software is expected to increase in the future. Therefore, continued development and support of Grid software is very important to the NP science community. Another key finding is that scientific productivity is greatly enhanced by easy researcher-local access to instrument data. This is driving the creation of distributed repositories for instrument data at collaborating institutions, along with a corresponding increase in demand for network-based data transfers and the tools

  2. 8th International Workshop on Chiral Dynamics

    CERN Document Server

    2016-01-01

    The International Workshop on Chiral Dynamics 2015, the eighth in a series which started in 1994 at MIT, and was later held in Mainz (1997), Jefferson Lab (2000 and 2012), Bonn (2003), Duke (2006) and Bern (2009), will take place in Pisa, from June 29 to July 3 2015, and will be jointly hosted by the Department of Physics of the University of Pisa and the Pisa branch of the Istituto Nazionale di Fisica Nucleare. The purpose of this workshop series is to bring physicists together who are active in this field, as well as those who are interested, to discuss and debate the most recent achievements and future developments. The workshop will have a near equal contribution from theorists and experimentalists and, as in the latest editions, a strong synergy with the lattice community will be present. Topics: Hadron structure Isospin breaking in hadronic systems Meson-meson and meson-baryon interaction Effective field theory and chiral perturbation theory Few-body physics Compton scattering and the polarizabilities o...

  3. Rotational Seismology Workshop of February 2006

    Science.gov (United States)

    Evans, John R.; Cochard, A.; Graizer, Vladimir; Huang, Bor-Shouh; Hudnut, Kenneth W.; Hutt, Charles R.; Igel, H.; Lee, William H.K.; Liu, Chun-Chi; Majewski, Eugeniusz; Nigbor, Robert; Safak, Erdal; Savage, William U.; Schreiber, U.; Teisseyre, Roman; Trifunac, Mihailo; Wassermann, J.; Wu, Chien-Fu

    2007-01-01

    Introduction A successful workshop titled 'Measuring the Rotation Effects of Strong Ground Motion' was held simultaneously in Menlo Park and Pasadena via video conference on 16 February 2006. The purpose of the Workshop and this Report are to summarize existing data and theory and to explore future challenges for rotational seismology, including free-field strong motion, structural strong motion, and teleseismic motions. We also forged a consensus on the plan of work to be pursued by this international group in the near term. At this first workshop were 16 participants in Menlo Park, 13 in Pasadena, and a few on the telephone. It was organized by William H. K. Lee and John R. Evans and chaired by William U. Savage in Menlo Park and by Kenneth W. Hudnut in Pasadena. Its agenda is given in the Appendix. This workshop and efforts in Europe led to the creation of the International Working Group on Rotational Seismology (IWGoRS), an international volunteer group providing forums for exchange of ideas and data as well as hosting a series of Workshops and Special Sessions. IWGoRS created a Web site, backed by an FTP site, for distribution of materials related to rotational seismology. At present, the FTP site contains the 2006 Workshop agenda (also given in the Appendix below) and its PowerPoint presentations, as well as many papers (reasonable-only basis with permission of their authors), a comprehensive citations list, and related information. Eventually, the Web site will become the sole authoritative source for IWGoRS and shared information: http://www.rotational-seismology.org ftp://ehzftp.wr.usgs.gov/jrevans/IWGoRS_FTPsite/ With contributions from various authors during and after the 2006 Workshop, this Report proceeds from the theoretical bases for making rotational measurements (Graizer, Safak, Trifunac) through the available observations (Huang, Lee, Liu, Nigbor), proposed suites of measurements (Hudnut), a discussion of broadband teleseismic rotational

  4. PREFACE: Galactic Center Workshop 2006

    Science.gov (United States)

    Schödel, Rainer; Bower, Geoffrey C.; Muno, Michael P.; Nayakshin, Sergei; Ott, Thomas

    2006-12-01

    stars in an environment that was previously thought hostile to star formation. Highlights of the GC Workshop 2002 in Kona were certainly the extraordinary evidence for the black hole nature of Sagittarius A* provided by the observation of orbits of individual stars around the central dark mass of the Milky Way, and the observations of short radiation outbreaks from Sgr A* in the X-ray regime, the so-called flares. These events with their variability on the minute time scale provided additional hard evidence for the black hole nature of Sgr A*. Also, the new observational capabilities provided by Chandraand XMMprovided spectacular new insights into the physics of the GC. With the black hole nature of Sagittarius A* now confirmed beyond reasonable doubt, theory and observation are zooming into ever smaller scales, trying to understand the exact physics behind the extreme under-luminosity (10-9 10-10 in terms of Eddington luminosity) of Sagittarius A*. Especially observations of the submm, NIR, and X-ray flares appear to be promising sources to analyze the accretion physics of Sagittarius A* near its event horizon. Some flares may carry the actual imprint of plasma moving at relativistic velocities near the last orbit of the black hole. Another topic that has moved into the focus of attention is star formation near the central black hole. One, possibly two, disks of young massive stars in the central half parsec, generally assumed hostile to star formation, challenge current theories of star formation. Through new infrared integral field spectrometers there is now strong evidence that the stars in the immediate environment of Sagittarius A*, the so-called S-stars are B-type main sequence stars. There are many hypothesis for their origin, but no model could yet provide entirely satisfactory explanations for their existence. A significant number of new telescopes and instruments access ever greater detail at all wavelengths. The continuing development of (sub

  5. Impact of After-School Nutrition Workshops in a Public Library Setting

    Science.gov (United States)

    Freedman, Marjorie R.; Nickell, Audrey

    2010-01-01

    Objective: To determine if after-school nutrition workshops conducted in public libraries were related to lasting changes in food choice. Methods: "Snack Smart" workshops, based on Social Cognitive Theory, were conducted in 8 branch libraries (49 ethnically diverse children, ages 9 to 14) to assess changes in consumption of targeted food items by…

  6. Planetarium Educator's Workshop Guide. International Planetarium Society Special Report No. 10.

    Science.gov (United States)

    Friedman, Alan; And Others

    Presented is a workshop guide for planetarium educators. Seven modules and four appendices focus on organizational patterns, learning theories, questioning strategies, activities for the planetarium, and incorporating all of the above into teaching. The four appendices include a list of the 1978 workshop participants, an annotated bibliography for…

  7. Positioning Sex Educators: A Critical Ethnography of a Professional Development Workshop

    Science.gov (United States)

    Scott, Brigitte C.

    2013-01-01

    In this ethnographic research, I offer an analysis of a state-sponsored professional development workshop for sex educators. Positioning theory is used to understand how the lived space of the workshop -- including texts, talk and silence -- positions sex education teachers as professionals and practitioners with certain (limited) speaking rights…

  8. Report of planning workshop on fluctuations and anomalous transport in tokamaks

    Energy Technology Data Exchange (ETDEWEB)

    1982-10-01

    The workshop was divided into three sections: review of experiments on fluctuations in tokamaks, review of theories of anomalous transport, and discussion of directions for future research and experimental/theoretical collaboration. Each session was assigned a recording secretary to take notes which were used in preparing this report. The report includes the activities, conclusions, and recommendations of the workshop.

  9. Report of planning workshop on fluctuations and anomalous transport in tokamaks

    International Nuclear Information System (INIS)

    1982-10-01

    The workshop was divided into three sections: review of experiments on fluctuations in tokamaks, review of theories of anomalous transport, and discussion of directions for future research and experimental/theoretical collaboration. Each session was assigned a recording secretary to take notes which were used in preparing this report. The report includes the activities, conclusions, and recommendations of the workshop

  10. EMSL Science Theme Advisory Panel Workshop - Atmospheric Aerosol Chemistry, Climate Change, and Air Quality

    Energy Technology Data Exchange (ETDEWEB)

    Baer, Donald R.; Finlayson-Pitts, Barbara J.; Allen, Heather C.; Bertram, Allan K.; Grassian, Vicki H.; Martin, Scot T.; Penner, Joyce E.; Prather, Kimberly; Rasch, Philip J.; Signorell, Ruth; Smith, James N.; Wyslouzil, Barbara; Ziemann, Paul; Dabdub, Donald; Furche, Filipp; Nizkorodov, Sergey; Tobias, Douglas J.; Laskin, Julia; Laskin, Alexander

    2013-07-01

    This report contains the workshop scope and recommendations from the workshop attendees in identifying scientific gaps in new particle formation, growth and properties of particles and reactions in and on particles as well as the laboratory-focused capabilities, field-deployable capabilities and modeling/theory tools along with linking of models to fundamental data.

  11. Workshops as a Research Methodology

    DEFF Research Database (Denmark)

    Ørngreen, Rikke; Levinsen, Karin Tweddell

    2017-01-01

    , and workshops as a research methodology. Focusing primarily on the latter, this paper presents five studies on upper secondary and higher education teachers’ professional development and on teaching and learning through video conferencing. Through analysis and discussion of these studies’ findings, we argue......This paper contributes to knowledge on workshops as a research methodology, and specifically on how such workshops pertain to e-learning. A literature review illustrated that workshops are discussed according to three different perspectives: workshops as a means, workshops as practice...... that workshops provide a platform that can aid researchers in identifying and exploring relevant factors in a given domain by providing means for understanding complex work and knowledge processes that are supported by technology (for example, e-learning). The approach supports identifying factors...

  12. UVI Cyber-security Workshop Workshop Analysis.

    Energy Technology Data Exchange (ETDEWEB)

    Kuykendall, Tommie G. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Allsop, Jacob Lee [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Anderson, Benjamin Robert [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Boumedine, Marc [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Carter, Cedric [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Galvin, Seanmichael Yurko [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gonzalez, Oscar [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lee, Wellington K. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lin, Han Wei [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Morris, Tyler Jake [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Nauer, Kevin S.; Potts, Beth A.; Ta, Kim Thanh; Trasti, Jennifer; White, David R.

    2015-07-08

    The cybersecurity consortium, which was established by DOE/NNSA’s Minority Serving Institutions Partnerships Program (MSIPP), allows students from any of the partner schools (13 HBCUs, two national laboratories, and a public school district) to have all consortia options available to them, to create career paths and to open doors to DOE sites and facilities to student members of the consortium. As a part of this year consortium activities, Sandia National Laboratories and the University of Virgin Islands conducted a week long cyber workshop that consisted of three courses; Digital Forensics and Malware Analysis, Python Programming, and ThunderBird Cup. These courses are designed to enhance cyber defense skills and promote learning within STEM related fields.

  13. Workshop: Waiting for the top quark

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    The world of elementary particle physics is eagerly waiting for the top quark, probably the final element of the 'periodic table' of elementary particle constituents. This table consists of two families of weakly interacting particles (leptons) - one series carrying electric charge; the other being electrically neutral - together with a family of quarks carrying electric charge 2/3 (up, charm, top) and a family of charge -1/3 quarks (down, strange, beauty). It was then not surprising that the 1990 Theory Workshop at the DESY Laboratory in Hamburg in October, devoted this time to 'top physics', attracted some 200 physicists, substantially more than previous workshops in the series

  14. GammaWorkshops Proceedings

    International Nuclear Information System (INIS)

    Ramebaeck, H.; Straelberg, E.; Klemola, S.; Nielsen, Sven P.; Palsson, S.E.

    2012-01-01

    Due to a sparse interaction during the last years between practioners in gamma ray spectrometry in the Nordic countries, a NKS activity was started in 2009. This GammaSem was focused on seminars relevant to gamma spectrometry. A follow up seminar was held in 2010. As an outcome of these activities it was suggested that the 2011 meeting should be focused on practical issues, e.g. different corrections needed in gamma spectrometric measurements. This three day's meeting, GammaWorkshops, was held in September at Risoe-DTU. Experts on different topics relevant for gamma spectrometric measurements were invited to the GammaWorkshops. The topics included efficiency transfer, true coincidence summing corrections, self-attenuation corrections, measurement of natural radionuclides (natural decay series), combined measurement uncertainty calculations, and detection limits. These topics covered both lectures and practical sessions. The practical sessions included demonstrations of tools for e.g. corrections and calculations of the above meantioned topics. (Author)

  15. Spiral 2 workshop

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    The accelerator and experimental facilities at GANIL will be transformed over the next 5-10 years. The centerpiece of the additions to the accelerator complex will be Spiral-2. This is the first phase of a new radioactive beam facility based on the ISOL principle. The main aim of Spiral-2 will be to produce intense, high quality beams of neutron-rich nuclei created in neutron-induced fission of heavy elements and accelerated by the existing CIME cyclotron. The principal aims of this workshop will be a) to publicize the new facilities, b) to discuss and define the science which might be carried out with them, c) to discuss the instrumentation and infrastructure required to exploit the new facilities and d) to help form collaborations of scientists wishing to design and construct the equipment needed to undertake the science programme. This document gathers most of the slides presented in the workshop.

  16. PREFACE: Collapse Calderas Workshop

    Science.gov (United States)

    Gottsmann, Jo; Aguirre-Diaz, Gerardo

    2008-10-01

    Caldera-formation is one of the most awe-inspiring and powerful displays of nature's force. Resultant deposits may cover vast areas and significantly alter the immediate topography. Post-collapse activity may include resurgence, unrest, intra-caldera volcanism and potentially the start of a new magmatic cycle, perhaps eventually leading to renewed collapse. Since volcanoes and their eruptions are the surface manifestation of magmatic processes, calderas provide key insights into the generation and evolution of large-volume silicic magma bodies in the Earth's crust. Despite their potentially ferocious nature, calderas play a crucial role in modern society's life. Collapse calderas host essential economic deposits and supply power for many via the exploitation of geothermal reservoirs, and thus receive considerable scientific, economic and industrial attention. Calderas also attract millions of visitors world-wide with their spectacular scenic displays. To build on the outcomes of the 2005 calderas workshop in Tenerife (Spain) and to assess the most recent advances on caldera research, a follow-up meeting was proposed to be held in Mexico in 2008. This abstract volume presents contributions to the 2nd Calderas Workshop held at Hotel Misión La Muralla, Querétaro, Mexico, 19-25 October 2008. The title of the workshop `Reconstructing the evolution of collapse calderas: Magma storage, mobilisation and eruption' set the theme for five days of presentations and discussions, both at the venue as well as during visits to the surrounding calderas of Amealco, Amazcala and Huichapan. The multi-disciplinary workshop was attended by more than 40 scientist from North, Central and South America, Europe, Australia and Asia. Contributions covered five thematic topics: geology, geochemistry/petrology, structural analysis/modelling, geophysics, and hazards. The workshop was generously supported by the International Association of Volcanology and the Chemistry of The Earth's Interior

  17. Accelerator reliability workshop

    Energy Technology Data Exchange (ETDEWEB)

    Hardy, L; Duru, Ph; Koch, J M; Revol, J L; Van Vaerenbergh, P; Volpe, A M; Clugnet, K; Dely, A; Goodhew, D

    2002-07-01

    About 80 experts attended this workshop, which brought together all accelerator communities: accelerator driven systems, X-ray sources, medical and industrial accelerators, spallation sources projects (American and European), nuclear physics, etc. With newly proposed accelerator applications such as nuclear waste transmutation, replacement of nuclear power plants and others. Reliability has now become a number one priority for accelerator designers. Every part of an accelerator facility from cryogenic systems to data storage via RF systems are concerned by reliability. This aspect is now taken into account in the design/budget phase, especially for projects whose goal is to reach no more than 10 interruptions per year. This document gathers the slides but not the proceedings of the workshop.

  18. Imaging Sciences Workshop Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Candy, J.V.

    1996-11-21

    This report contains the proceedings of the Imaging Sciences Workshop sponsored by C.A.S.LS., the Center for Advanced Signal & Image Sciences. The Center, established primarily to provide a forum where researchers can freely exchange ideas on the signal and image sciences in a comfortable intellectual environment, has grown over the last two years with the opening of a Reference Library (located in Building 272). The Technical Program for the 1996 Workshop include a variety of efforts in the Imaging Sciences including applications in the Microwave Imaging, highlighted by the Micro-Impulse Radar (MIR) system invented at LLNL, as well as other applications in this area. Special sessions organized by various individuals in Speech, Acoustic Ocean Imaging, Radar Ocean Imaging, Ultrasonic Imaging, and Optical Imaging discuss various applica- tions of real world problems. For the more theoretical, sessions on Imaging Algorithms and Computed Tomography were organized as well as for the more pragmatic featuring a session on Imaging Systems.

  19. Accelerator reliability workshop

    International Nuclear Information System (INIS)

    Hardy, L.; Duru, Ph.; Koch, J.M.; Revol, J.L.; Van Vaerenbergh, P.; Volpe, A.M.; Clugnet, K.; Dely, A.; Goodhew, D.

    2002-01-01

    About 80 experts attended this workshop, which brought together all accelerator communities: accelerator driven systems, X-ray sources, medical and industrial accelerators, spallation sources projects (American and European), nuclear physics, etc. With newly proposed accelerator applications such as nuclear waste transmutation, replacement of nuclear power plants and others. Reliability has now become a number one priority for accelerator designers. Every part of an accelerator facility from cryogenic systems to data storage via RF systems are concerned by reliability. This aspect is now taken into account in the design/budget phase, especially for projects whose goal is to reach no more than 10 interruptions per year. This document gathers the slides but not the proceedings of the workshop

  20. Spiral 2 workshop

    International Nuclear Information System (INIS)

    2004-01-01

    The accelerator and experimental facilities at GANIL will be transformed over the next 5-10 years. The centerpiece of the additions to the accelerator complex will be Spiral-2. This is the first phase of a new radioactive beam facility based on the ISOL principle. The main aim of Spiral-2 will be to produce intense, high quality beams of neutron-rich nuclei created in neutron-induced fission of heavy elements and accelerated by the existing CIME cyclotron. The principal aims of this workshop will be a) to publicize the new facilities, b) to discuss and define the science which might be carried out with them, c) to discuss the instrumentation and infrastructure required to exploit the new facilities and d) to help form collaborations of scientists wishing to design and construct the equipment needed to undertake the science programme. This document gathers most of the slides presented in the workshop

  1. ARCSACC '99: Workshop Proceedings

    International Nuclear Information System (INIS)

    Nahir, M.; Biggar, K.

    1999-01-01

    The assessment and remediation of contaminated sites in cold and Arctic environments is an area of increasing concern, primarily because of the unique problems associated with northern regions. Not only the obvious effects of the cold temperatures on the operation of many systems, but also remedial effectiveness of measures under extreme cold conditions are of interest. Accordingly, this workshop was organized to provide a means of exchange of information among people responsible for cleaning-up contaminated sites in cold and Arctic environments, researchers, and providers of remediation services with experience in dealing with such conditions. Speakers at the workshop addressed problems concerning risk assessment and site characterization, contaminant migration in permafrost, contamination caused by mining and associated clean-up problems, assessed bioremediation as a means of contaminant control, reviewed various remediation technologies and techniques, and presented a number of bioremediation case studies. refs., tabs., figs

  2. Workshop on decommissioning

    International Nuclear Information System (INIS)

    Broden, K.

    2005-12-01

    A Nordic workshop on decommissioning of nuclear facilities was held at Risoe in Denmark September 13-15, 2005. The workshop was arranged by NKS in cooperation with the company Danish Decommissioning, DD, responsible for decommissioning of nuclear facilities at Risoe. Oral presentations were made within the following areas: International and national recommendations and requirements concerning decommissioning of nuclear facilities Authority experiences of decommissioning cases Decommissioning of nuclear facilities in Denmark Decommissioning of nuclear facilities in Sweden Plans for decommissioning of nuclear facilities in Norway Plans for decommissioning of nuclear facilities in Finland Decommissioning of nuclear facilities in German and the UK Decommissioning of nuclear facilities in the former Soviet Union Results from research and development A list with proposals for future work within NKS has been prepared based on results from group-work and discussions. The list contains strategic, economical and political issues, technical issues and issues regarding competence and communication. (au)

  3. Solar workshops financial incentives

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-01-01

    Ten one-day workshops were held across the United States. Information in this workbook is compiled in conjunction with those workshops. The following discussions are included: solar as a fuel (history); why alternative fuels are being sought today; the need for conservation; advantages of solar energy; the potential of solar energy; why solar energy is not more widely used; a definition of solar; how solar can help meet energy demands; Federal policies and programs; what solar technologies exist today that can be effectively utilized (thermal applications, fuels from biomass, solar electric). Additional information is presented in three attachments: Energy-Conserving Methods; Domestic Policy Review of Solar Energy; and DOE Secretary's Annual Report to Congress-Solar Section. (MCW)

  4. RADIOFREQUENCY SUPERCONDUCTIVITY: Workshop

    International Nuclear Information System (INIS)

    Lengeler, Herbert

    1989-01-01

    Superconducting radiofrequency is already playing an important role in the beam acceleration system for the TRISTAN electron-positron collider at the Japanese KEK Laboratory and new such systems are being prepared for other major machines. Thus the fourth Workshop on Radiofrequency Superconductivity, organized by KEK under the chairmanship of local specialist Yuzo Kojima and held just before the International Conference on High Energy Accelerators, had much progress to review and even more to look forward to

  5. Workshop UNK-600 (proceedings)

    International Nuclear Information System (INIS)

    Zajtsev, A.M.; Bitykov, S.I.

    1994-01-01

    Proceedings are presented of the workshop devoted to the accelerating storage complex of IHEP (UNK-600). In the first section is given the information on the present status of the UNK-600 and particle channels design and on the adopted experiment NEPTUN-A. In the papers of the second section are discussed hadron physics investigations at 600 GeV. Experiments in the neutrino and muon beams are analyzed. A possible program of studying the charged kaon rare decays is described

  6. Experimental halls workshop summary

    International Nuclear Information System (INIS)

    Thorndike, A.

    1976-01-01

    At the experimental halls workshop, discussions were held on: (1) open areas as compared with enclosed halls; (2) the needs of ep, anti pp, and other options; (3) the hall for the lepton detector; and (4) the hall for the hadron spectrometer. The value of different possibilities for the future experimental program was explored. A number of suggestions emerged which will be used as the design of the experimental halls progresses

  7. Imaging sciences workshop

    Energy Technology Data Exchange (ETDEWEB)

    Candy, J.V.

    1994-11-15

    This workshop on the Imaging Sciences sponsored by Lawrence Livermore National Laboratory contains short abstracts/articles submitted by speakers. The topic areas covered include the following: Astronomical Imaging; biomedical imaging; vision/image display; imaging hardware; imaging software; Acoustic/oceanic imaging; microwave/acoustic imaging; computed tomography; physical imaging; imaging algorithms. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

  8. International Social Pharmacy Workshop

    OpenAIRE

    Cordina, Maria; Journal of the Malta College of Pharmacy Practice Editorial Board

    2003-01-01

    The Malta College of Pharmacy Practice, will be hosting the 13th International Social Pharmacy Workshop next summer. The concept of social pharmacy is very clearly explained in the article by Professor Ellen West Sørensen and colleagues, who are considered to be pioneers in this field. Malta has successfully hosted a number of pharmacy conferences, however this one is somewhat different and rather special.

  9. WORKSHOP: Radiofrequency superconductivity

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1984-10-15

    The Second Workshop on Radiofrequency Superconductivity was held at CERN from 23-27 July, four years after the first, organized at Karlsruhe. 35 invited talks were presented to the about 80 participants from Australia, Brazil, Europe, Japan and the United States. For the first time, ten Laboratories operating or planning superconducting accelerators for heavy ions participated and shared their experience with the community proposing the use of superconducting accelerating sections for electron accelerators.

  10. WORKSHOP: Radiofrequency superconductivity

    International Nuclear Information System (INIS)

    Anon.

    1984-01-01

    The Second Workshop on Radiofrequency Superconductivity was held at CERN from 23-27 July, four years after the first, organized at Karlsruhe. 35 invited talks were presented to the about 80 participants from Australia, Brazil, Europe, Japan and the United States. For the first time, ten Laboratories operating or planning superconducting accelerators for heavy ions participated and shared their experience with the community proposing the use of superconducting accelerating sections for electron accelerators

  11. Auroral Tomography Workshop, Proceedings

    International Nuclear Information System (INIS)

    Steen, Aa.

    1993-08-01

    In ionospheric and atmospheric physics the importance of multi-station imaging has grown as a consequence of the availability of scientific grade CCD cameras with digital output and affordable massive computing power. Tomographic inversion techniques are used in many different areas, e.g. medicine, plasma research and space physics. The tomography workshop was announced to gather a limited group of people interested in auroral tomography or tomographic inversion methods in general. ALIS (Auroral Large Imaging System) is a multi-station ground-based system developed primarily for three-dimensional auroral imaging, however other non-auroral objects can be studied with ALIS, e.g. stratospheric clouds. Several of the contributions in the workshop dealt with problems related to geometries similar to the ALIS-configuration. The Proceedings contain written contributions received either in abstract form or as full papers. The Proceedings also contain contributions intended for the Workshop but not presented due to the absence of the speaker. Separate abstracts have been prepared for 15 of the 17 papers

  12. The Astronomy Workshop

    Science.gov (United States)

    Hamilton, D. P.

    2005-05-01

    The Astronomy Workshop (http://janus.astro.umd.edu) is a collection of interactive online educational tools developed for use by students, educators, and the general public. The more than 20 tools in the Astronomy Workshop are rated for ease-of-use, and have been extensively tested in large university survey courses, classes for undergraduate majors, and High Schools. Here we briefly describe a few of the more popular tools. The Life of the Sun (New!): The history of the Sun is animated as a movie, showing students how the size and color of our star has evolved and will evolve in time. Animated Orbits of Planets and Moons: The orbital motions of planets, moons, asteroids, and comets are animated at their correct relative speeds in accurate to-scale drawings. Solar System Collisions: This most popular of our applications shows what happens when an asteroid or comet with user-defined size and speed impacts a given planet. The program calculates many effects, including the country of impact (if Earth is the target), energy of explosion, crater size, and magnitude of the ``planetquake'' generated. It also displays a relevant image (e.g. terrestrial crater, lunar crater, etc.). Astronomical Distances: Travel away from the Earth at a chosen speed and see how long it takes to reach other planets, stars and galaxies. This tool helps students visualize astronomical distances in an intuitive way. Funding for the Astronomy Workshop is provided by a NASA EPO grant.

  13. Grid and Entrepreneurship Workshop

    CERN Multimedia

    2006-01-01

    The CERN openlab is organising a special workshop about Grid opportunities for entrepreneurship. This one-day event will provide an overview of what is involved in spin-off technology, with a special reference to the context of computing and data Grids. Lectures by experienced entrepreneurs will introduce the key concepts of entrepreneurship and review, in particular, the industrial potential of EGEE (the EU co-funded Enabling Grids for E-sciencE project, led by CERN). Case studies will be given by CEOs of European start-ups already active in the Grid and computing cluster area, and regional experts will provide an overview of efforts in several European regions to stimulate entrepreneurship. This workshop is designed to encourage students and researchers involved or interested in Grid technology to consider the entrepreneurial opportunities that this technology may create in the coming years. This workshop is organized as part of the CERN openlab student programme, which is co-sponsored by CERN, HP, ...

  14. Summary of the Workshop

    International Nuclear Information System (INIS)

    Myers, S; Zimmermann, F

    2012-01-01

    The summary session of the LHC Performance Workshop in Chamonix, 6-10 February 2012, synthesized one week of presentations and intense discussions on the near-, medium- and long-term strategy for the LHC and LHC upgrades. In particular, Chamonix’12 discussed the lessons from 2011, the strategy, beam energy and beam parameters for 2012, the planning for the Long Shutdown no. 1 (LS1), the measures and schemes for improving or maintaining the machine availability at higher beam energy, the injector performance and injector upgrade schedule, the HL-LHC project as well as possible additional or future LHC upgrades like LHeC and HELHC. Key workshop themes included the risk associated with 4 TeV beam energy in 2012, the beam energy after LS1, the turnaround time, the physics goal and optimized running schedule for 2012, the achievements and plans for Pb-Pb and p-Pb collisions, beam-beam effects, electron-cloud phenomena and UFOs. We report the proposals for decisions which have emerged at the Chamonix’12 workshop. (author)

  15. Summary of the Workshop

    Energy Technology Data Exchange (ETDEWEB)

    Myers, S; Zimmermann, F [European Organization for Nuclear Research, Geneva (Switzerland)

    2012-07-01

    The summary session of the LHC Performance Workshop in Chamonix, 6-10 February 2012, synthesized one week of presentations and intense discussions on the near-, medium- and long-term strategy for the LHC and LHC upgrades. In particular, Chamonix’12 discussed the lessons from 2011, the strategy, beam energy and beam parameters for 2012, the planning for the Long Shutdown no. 1 (LS1), the measures and schemes for improving or maintaining the machine availability at higher beam energy, the injector performance and injector upgrade schedule, the HL-LHC project as well as possible additional or future LHC upgrades like LHeC and HELHC. Key workshop themes included the risk associated with 4 TeV beam energy in 2012, the beam energy after LS1, the turnaround time, the physics goal and optimized running schedule for 2012, the achievements and plans for Pb-Pb and p-Pb collisions, beam-beam effects, electron-cloud phenomena and UFOs. We report the proposals for decisions which have emerged at the Chamonix’12 workshop. (author)

  16. The ROS Workshop

    CERN Multimedia

    Francis, D.

    The first week of February saw the taking place of the ReadOut Subsystem (ROS) workshop. The ROS is the subsystem of the Trigger, DAQ & DCS project which receives and buffers data from the detector ReadOut Drivers (RODs). On request it then provides a subset of this buffered data, the so-called Regions of Interest (RoI), to the Level 2 trigger. Using the subsequent Level 2 trigger decision, the ROS either removes the buffered event data from its buffers or sends the full event data to the Event Filter for further processing. The workshop took place over a four-day period at a location in the Jura. The average daily attendance was twenty people, which mainly represented the five main ATLAS institutes currently engaged in this Trigger, DAQ & DCS activity. The aim of the workshop was to bring to an end the current prototyping activities in this area and launch the next, final, phase of prototyping. This new phase of prototyping will build on the successful activities of the previous phase and will focus...

  17. Research workshops as a Means to individual and organizational learning and transformation

    DEFF Research Database (Denmark)

    Sommer, Finn M.; Sprogøe, Jonas; Nygaard Andersen, Randi

    In this empirical paper we explore experiences with organizing so called research workshops in a university of applied science. A research workshop is a action learning oriented didactical and educational format designed to be explorative, and the aim is for the participants to acquire research s...... skills and competencies. However, research workshops are also used strategically to facilitate organizational development. By way of organizational learning theory, we discuss research workshops as way to individual learning and organizational transformation.......In this empirical paper we explore experiences with organizing so called research workshops in a university of applied science. A research workshop is a action learning oriented didactical and educational format designed to be explorative, and the aim is for the participants to acquire research...

  18. Towards a theory of spacetime theories

    CERN Document Server

    Schiemann, Gregor; Scholz, Erhard

    2017-01-01

    This contributed volume is the result of a July 2010 workshop at the University of Wuppertal Interdisciplinary Centre for Science and Technology Studies which brought together world-wide experts from physics, philosophy and history, in order to address a set of questions first posed in the 1950s: How do we compare spacetime theories? How do we judge, objectively, which is the “best” theory? Is there even a unique answer to this question? The goal of the workshop, and of this book, is to contribute to the development of a meta-theory of spacetime theories. Such a meta-theory would reveal insights about specific spacetime theories by distilling their essential similarities and differences, deliver a framework for a class of theories that could be helpful as a blueprint to build other meta-theories, and provide a higher level viewpoint for judging which theory most accurately describes nature. But rather than drawing a map in broad strokes, the focus is on particularly rich regions in the “space of spaceti...

  19. Workshop on Squeezed States and Uncertainty Relations

    International Nuclear Information System (INIS)

    Han, D.; Kim, Y.S.; Zachary, W.W.

    1992-02-01

    The proceedings from the workshop are presented, and the focus was on the application of squeezed states. There are many who say that the potential for industrial applications is enormous, as the history of the conventional laser suggests. All those who worked so hard to produce squeezed states of light are continuing their efforts to construct more efficient squeezed-state lasers. Quite naturally, they are looking for new experiments using these lasers. The physical basis of squeezed states is the uncertainty relation in Fock space, which is also the basis for the creation and annihilation of particles in quantum field theory. Indeed, squeezed states provide a unique opportunity for field theoreticians to develop a measurement theory for quantum field theory

  20. 2014 Penn State Bioinorganic Workshop

    Energy Technology Data Exchange (ETDEWEB)

    Golbeck, John [Pennsylvania State Univ., State College, PA (United States)

    2015-10-01

    The 3rd Penn State Bioinorganic Workshop took place in early June 2014 and was combined with the 3rd Penn State Frontiers in Metallobiochemistry Symposium. The workshop was even larger than the 2nd Penn State Bioinorganic Workshop we offered in 2012. It had even more participants (162 rather than 123 in 2012). Like the 2012 workshop, the 2014 workshop had three parts. The first part consisted of 16 90-minute lectures presented by faculty experts on the topic of their expertise (see below). Based on the suggestions from the 2012 workshop, we have recorded all 16 lectures professionally and make them available to the entire bioinorganic community via online streaming. In addition, hard copies of the recordings are available as backup.

  1. Developing a Lecturer Workshop for Using Tablets in the Classroom

    Science.gov (United States)

    Louw, Arno

    2015-01-01

    This paper is about a framework as heuristic to design and develop a workshop for academic teaching staff to use tablets for teaching and learning in the classroom at the University of Johannesburg (UJ). Theories of Cultural-Historical Activity and Engeström's activity systems are also incorporated, as are a critique and a critical analysis of the…

  2. Summer Workshop on Physics, Mathematics, and All That Quantum Jazz

    CERN Document Server

    Bando, Masamitsu; Güngördü, Utkan; Physics, Mathematics, and All That Quantum Jazz

    2014-01-01

    This book is a collection of contributions from a Summer Workshop on Physics, Mathematics, and All That Quantum Jazz . Subjects of the symposium include quantum information theory, quantum annealing, Bose gases, and thermodynamics from a viewpoint of quantum physics. Contributions to this book are prepared in a self-contained manner so that readers with a modest background may understand the subjects.

  3. Mini-Proceedings of ECT Workshop Strangeness in Nuclei

    CERN Document Server

    Zmeskal, J

    2011-01-01

    This workshop brought together international experts in the research area of strangeness in nuclei physics, working on theory as well as on experiments, to discuss the present status, to develop new methods of analysis and to have the opportunity for brainstorming towards future studies, going towards a deeper understanding of the hot topics in the low-energy QCD in the strangeness sector.

  4. Richie, Alicia, and the New Time of Literacy Workshops.

    Science.gov (United States)

    McAndrew, Donald A.

    1993-01-01

    Discusses the apparent chaos of two student activities in a seventh-grade reading and writing workshop in the light of physicists' recent theories of time. Show how time is thought to be organic and evolving, with the past active in the present, and with students using time not in a linear way but as a whole. (SR)

  5. Proceedings of the Budapest workshop on relativistic heavy ion collisions

    International Nuclear Information System (INIS)

    Csoergoe, T.; Hegyi, S.; Levai, P.

    1993-04-01

    This volume is the Proceedings of the Budapest workshop on relativistic heavy ion collisions held in Budapest, 10-13 Aug, 1992. The topics include experimental heavy ion physics, Bose-Einstein correlations, intermittency, relativistic transport theory, Quark-Gluon Plasma rehadronization, astronuclear physics and cosmology. All contributions were indexed and abstracted. (author)

  6. 7th International Workshop on Boosted Object Phenomenology, Reconstruction and Searches in HEP

    CERN Document Server

    2015-01-01

    BOOST2015 is the seventh of a series of successful joint theory/experiment workshops which bring together the world leading experts from theory and the Tevatron and LHC experiments to discuss the latest progress and develop new approaches on the reconstruction and use of boosted decay topologies as search tools for new physics. This year, the workshop is hosted by the University of Chicago.

  7. Diabetic foot workshop: Improving technical and educational skills for nurses.

    Science.gov (United States)

    Aalaa, Maryam; Sanjari, Mahnaz; Shahbazi, Samimeh; Shayeganmehr, Zahra; Abooeirad, Maryam; Amini, Mohammad Reza; Adibi, Hossien; Mehrdad, Neda

    2017-01-01

    Diabetes mellitus as one of the most common metabolic disorders has some complications, one of the main ones is diabetic foot (DF). Appropriate care and education prevents 85% of diabetic foot amputations. An ideal management to prevent and treat diabetic foot necessitates a close collaboration between the health team members and the diabetic patient. Therefore, improving nurses' knowledge about DF care and advancement in the quality of care provided by the nurses could significantly improve diabetic foot prevention and management. Therefore, the aim of DF workshop was to improve technical and educational skills of the nurses to prevent and manage diabetic foot. Considering the vital role of the nurses in providing DF care, EMRI decided to conduct Diabetic foot workshop for them. The following five steps were designed for the 14 coordinating sessions in the workshop: Goals definition, deciding about attendees, location selection, creating agenda, and developing a follow-up plan. "Diabetic Foot Workshop for Nurses" provides appropriate training to DF nurses at the national level; and combining theory and practice in this workshop not only increases nurses' knowledge, but also improves their skills in the field of the diabetic foot. Providing education and care to patients by DF nurse specialists instead of general nurses could be an important output of this workshop, which may lead to DF prevention and amputation decrease in the long term.

  8. Cognitive aspects in games workshops for learning a foreign language

    Directory of Open Access Journals (Sweden)

    Claudia Ferrareto Lopes

    2014-08-01

    Full Text Available The goal of the study was to analyze the cognitive aspects related to learning English as a foreign language, by means of games workshops with students of the 6th grade of elementary school from a state school in Londrina. The paper is grounded on Piagetian theory and is descriptive-interpretative study with a qualitative perspective. Two guiding questions motivate the study: what is the role of games workshops for learning English as a foreign language? In what way the cognitive processes are held in the games workshops for learning English? To meet the proposed goals, workshops were implemented with games containing the linguistic contents studied in English classes. The games workshops enabled the observation and analysis of the cognitive aspects involved in learning a foreign language. Results show that the games workshops promote the participation of the students motivating action and output, evidencing gaps on the knowledge and providing equilibration processes. Subjects are asked to produce outputs via games demands, thus evoking knowhow, as well as the thinking about their own products, suggesting a conscious-awareness process.

  9. Optical Network Testbeds Workshop

    Energy Technology Data Exchange (ETDEWEB)

    Joe Mambretti

    2007-06-01

    This is the summary report of the third annual Optical Networking Testbed Workshop (ONT3), which brought together leading members of the international advanced research community to address major challenges in creating next generation communication services and technologies. Networking research and development (R&D) communities throughout the world continue to discover new methods and technologies that are enabling breakthroughs in advanced communications. These discoveries are keystones for building the foundation of the future economy, which requires the sophisticated management of extremely large qualities of digital information through high performance communications. This innovation is made possible by basic research and experiments within laboratories and on specialized testbeds. Initial network research and development initiatives are driven by diverse motives, including attempts to solve existing complex problems, the desire to create powerful new technologies that do not exist using traditional methods, and the need to create tools to address specific challenges, including those mandated by large scale science or government agency mission agendas. Many new discoveries related to communications technologies transition to wide-spread deployment through standards organizations and commercialization. These transition paths allow for new communications capabilities that drive many sectors of the digital economy. In the last few years, networking R&D has increasingly focused on advancing multiple new capabilities enabled by next generation optical networking. Both US Federal networking R&D and other national R&D initiatives, such as those organized by the National Institute of Information and Communications Technology (NICT) of Japan are creating optical networking technologies that allow for new, powerful communication services. Among the most promising services are those based on new types of multi-service or hybrid networks, which use new optical networking

  10. Report of the Orientation Workshop

    DEFF Research Database (Denmark)

    Nunez, Heilyn Camacho; Buus, Lillian; Ogange, Betty

    2014-01-01

    This Orientation Workshops is part of MAAGART project. The workshop is divided in three parts: 1) pre-Orientation Workshop stage, 2) Face-to-Face stage and 3) post-Orientation stage. Pre and post stages will be developed online. All the activities will take place in a virtual learning environment...... created for this purpose. Participants will receive all the information about how to access the virtual learning environment (Moodle) prior to the pre-orientation workshop. In this report we cover only the two first stages. Jørgen Bang, as a part of the Community of Practice activity, will be facilitating...

  11. PREFACE: International Workshop on Dirac Electrons in Solids 2015

    Science.gov (United States)

    Ogata, M.; Suzumura, Y.; Fuseya, Y.; Matsuura, H.

    2015-04-01

    It is our pleasure to publish the Proceedings of the International Workshop on Dirac Electrons in Solids held in University of Tokyo, Japan, for January 14-15, 2015. The workshop was organized by the entitled project which lasted from April 2012 to March 2015 with 10 theorists. It has been supported by a Grand-in-Aid for Scientific Research (A) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan. The subjects discussed in the workshop include bismuth, organic conductors, graphene, topological insulators, new materials including Ca3PbO, and new directions in theory (superconductivity, orbital susceptibility, etc). The number of participants was about 70 and the papers presented in the workshop include four invited talks, 16 oral presentations, and 23 poster presentations. Dirac electron systems appear in various systems, such as graphene, quasi-two-dimensional organic conductors, bismuth, surface states in topological insulators, new materials like Ca3PbO. In these systems, characteristic transport properties caused by the linear dispersion of Dirac electrons and topological properties, have been extensively discussed. In addition to these, there are many interesting research fields such as Spin-Hall effect, orbital diamagnetism due to interband effects, Landau levels characteristic to Dirac dispersion, anomalous interlayer transport phenomena and magnetoresistance, the effects of spin-orbit interaction, and electron correlation. The workshop focused on recent developments of theory and experiment of Dirac electron systems in the above materials. We note that all papers published in this volume of Journal of Physics: Conference Series were peer reviewed. Reviews were performed by expert referees with professional knowledge and high scientific standards in this field. Editors made efforts so that the papers may satisfy the criterion of a proceedings journal published by IOP Publishing. We hope that all the participants of the workshop

  12. XIII International Workshop on Hadron Physics

    CERN Document Server

    2015-01-01

    The XIII International Workshop on Hadron Physics, XIII Hadron Physics, is intended for graduate students, postdocs and researchers in Hadronic Physics, High Energy Physics, Astrophysics and Effective Field Theories, who wish to improve their theoretical background, learn about recent experimental results and develop collaboration projects. The series Hadron Physics, in activity since 1988, has the format of an advanced school and has the objective to introduce, in a series of pedagogical lectures, new lines of research in Strong Interaction Physics, mainly concerned with QCD. It envisages also to stimulate collaborations in international level.

  13. North Region ROW tool implementation workshop.

    Science.gov (United States)

    2010-08-02

    Welcome to the North Region ROW Tool Workshop. This workshop is funded under an implementation project sponsored by TxDOTs Research & Technology Implementation Office (RTI). This is the second of four regional workshops being planned for this summ...

  14. Algorithm Theory - SWAT 2006

    DEFF Research Database (Denmark)

    This book constitutes the refereed proceedings of the 10th Scandinavian Workshop on Algorithm Theory, SWAT 2006, held in Riga, Latvia, in July 2006. The 36 revised full papers presented together with 3 invited papers were carefully reviewed and selected from 154 submissions. The papers address all...

  15. 77 FR 12313 - Food Labeling Workshop; Public Workshop

    Science.gov (United States)

    2012-02-29

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2012-N-0001] Food Labeling Workshop; Public Workshop AGENCY: Food and Drug Administration, HHS. ACTION: Notice of... District Office (DALDO), in collaboration with Oklahoma State University (OSU), Robert M. Kerr Food...

  16. 75 FR 29775 - Food Labeling Workshop; Public Workshop

    Science.gov (United States)

    2010-05-27

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES [Docket No. FDA-2010-N-0001] Food and Drug Administration Food Labeling Workshop; Public Workshop AGENCY: Food and Drug Administration, HHS. ACTION: Notice of...: Institute of Food Science & Engineering, University of Arkansas, 2650 North Young Ave., Fayetteville, AR...

  17. Coherent structures in tokamak plasmas workshop: Proceedings

    International Nuclear Information System (INIS)

    Koniges, A.E.; Craddock, G.G.

    1992-08-01

    Coherent structures have the potential to impact a variety of theoretical and experimental aspects of tokamak plasma confinement. This includes the basic processes controlling plasma transport, propagation and efficiency of external mechanisms such as wave heating and the accuracy of plasma diagnostics. While the role of coherent structures in fluid dynamics is better understood, this is a new topic for consideration by plasma physicists. This informal workshop arose out of the need to identify the magnitude of structures in tokamaks and in doing so, to bring together for the first time the surprisingly large number of plasma researchers currently involved in work relating to coherent structures. The primary purpose of the workshop, in addition to the dissemination of information, was to develop formal and informal collaborations, set the stage for future formation of a coherent structures working group or focus area under the heading of the Tokamak Transport Task Force, and to evaluate the need for future workshops on coherent structures. The workshop was concentrated in four basic areas with a keynote talk in each area as well as 10 additional presentations. The issues of discussion in each of these areas was as follows: Theory - Develop a definition of structures and coherent as it applies to plasmas. Experiment - Review current experiments looking for structures in tokamaks, discuss experimental procedures for finding structures, discuss new experiments and techniques. Fluids - Determine how best to utilize the resource of information available from the fluids community both on the theoretical and experimental issues pertaining to coherent structures in plasmas. Computation - Discuss computational aspects of studying coherent structures in plasmas as they relate to both experimental detection and theoretical modeling

  18. Workshop on Radio Recombination Lines

    CERN Document Server

    1980-01-01

    Since their first detection 15 years ago, radio recombination lines from several elements have been observed in a wide variety of objects including HII regions, planetary nebulae, molecular clouds, the diffuse interstellar medium, and recently, other galaxies. The observations span almost the entire range from 0.1 to 100 GHz, and employ both single­ djsh and aperture synthesis techniques. The theory of radio recombination lines has also advanced strongly, to the point where it is perhaps one of the best-understood in astro­ physics. In a parallel development, it has become possible over the last decade to study these same highly-excited atoms in the laboratory; this work provides further confirmation of the theoretical framework. However there has been continuing controversy over the astrophysical interpre­ tation of radio recombination line observations, especially regarding the role of stimulated emission. A workshop was held in Ottawa on 24-25 August, 1979, bringing together many of the active scientist...

  19. WORKSHOP: Stable particle motion

    International Nuclear Information System (INIS)

    Ruggiero, Alessandro G.

    1993-01-01

    Full text: Particle beam stability is crucial to any accelerator or collider, particularly big ones, such as Brookhaven's RHIC heavy ion collider and the larger SSC and LHC proton collider schemes. A workshop on the Stability of Particle Motion in Storage Rings held at Brookhaven in October dealt with the important issue of determining the short- and long-term stability of single particle motion in hadron storage rings and colliders, and explored new methods for ensuring it. In the quest for realistic environments, the imperfections of superconducting magnets and the effects of field modulation and noise were taken into account. The workshop was divided into three study groups: Short-Term Stability in storage rings, including chromatic and geometric effects and correction strategies; Long-Term Stability, including modulation and random noise effects and slow varying effects; and Methods for determining the stability of particle motion. The first two were run in parallel, but the third was attended by everyone. Each group considered analytical, computational and experimental methods, reviewing work done so far, comparing results and approaches and underlining outstanding issues. By resolving conflicts, it was possible to identify problems of common interest. The workshop reaffirmed the validity of methods proposed several years ago. Major breakthroughs have been in the rapid improvement of computer capacity and speed, in the development of more sophisticated mathematical packages, and in the introduction of more powerful analytic approaches. In a typical storage ring, a particle may be required to circulate for about a billion revolutions. While ten years ago it was only possible to predict accurately stability over about a thousand revolutions, it is now possible to predict over as many as one million turns. If this trend continues, in ten years it could become feasible to predict particle stability over the entire storage period. About ninety participants

  20. Workshop objectives and structure

    International Nuclear Information System (INIS)

    2004-01-01

    The overall aim of the Workshop was to create a platform in order to better understand different approaches to managing uncertainty in post-closure safety cases and regulatory approaches in different national waste management programmes. The principal objectives of the Workshop were to: - To identify common elements in different approaches for managing uncertainty. - To facilitate information exchange and to promote discussion on different technical approaches to the management and characterisation of uncertainty and on the role of risk. - To explore the merits of alternative approaches to risk-informed decision making. - To identify the potential for further developments of methods or strategies to support the management of uncertainties. The workshop was organised into plenary sessions and working group discussions: The first plenary session focused on establishing a framework for understanding the management of uncertainties and the use of risk. It comprised oral presentations drawing on a range of experience from both active participants in the development and assessment of safety cases and keynotes presentations by external participants involved in risk management in other sectors. The working group discussions covered three technical themes: Risk management and decision making. Regulatory requirements and review of uncertainty and risk in safety cases. Practical approaches and tools for the management of uncertainties and the assignment of probabilities, the use of expert judgements, and the presentation of information on uncertainties and risk were examined. The aim of the working groups was to develop an understanding of the specific issues, and to identify any further activities that will support the development and/or evaluation of safety cases. The round up plenary session brought together information and conclusions from each of the working groups. Common elements in the different approaches to treating uncertainty and risk were identified, along with

  1. Summary from the epistemic uncertainty workshop: consensus amid diversity

    International Nuclear Information System (INIS)

    Ferson, Scott; Joslyn, Cliff A.; Helton, Jon C.; Oberkampf, William L.; Sentz, Kari

    2004-01-01

    The 'Epistemic Uncertainty Workshop' sponsored by Sandia National Laboratories was held in Albuquerque, New Mexico, on 6-7 August 2002. The workshop was organized around a set of Challenge Problems involving both epistemic and aleatory uncertainty that the workshop participants were invited to solve and discuss. This concluding article in a special issue of Reliability Engineering and System Safety based on the workshop discusses the intent of the Challenge Problems, summarizes some discussions from the workshop, and provides a technical comparison among the papers in this special issue. The Challenge Problems were computationally simple models that were intended as vehicles for the illustration and comparison of conceptual and numerical techniques for use in analyses that involve: (i) epistemic uncertainty, (ii) aggregation of multiple characterizations of epistemic uncertainty, (iii) combination of epistemic and aleatory uncertainty, and (iv) models with repeated parameters. There was considerable diversity of opinion at the workshop about both methods and fundamental issues, and yet substantial consensus about what the answers to the problems were, and even about how each of the four issues should be addressed. Among the technical approaches advanced were probability theory, Dempster-Shafer evidence theory, random sets, sets of probability measures, imprecise coherent probabilities, coherent lower previsions, probability boxes, possibility theory, fuzzy sets, joint distribution tableaux, polynomial chaos expansions, and info-gap models. Although some participants maintained that a purely probabilistic approach is fully capable of accounting for all forms of uncertainty, most agreed that the treatment of epistemic uncertainty introduces important considerations and that the issues underlying the Challenge Problems are legitimate and significant. Topics identified as meriting additional research include elicitation of uncertainty representations, aggregation of

  2. WORKSHOP: Crystalline beams

    International Nuclear Information System (INIS)

    Anon.

    1989-01-01

    Following pioneer work by specialists at the Soviet Novosibirsk Laboratory some ten years ago, interest developed in the possibility of 'freezing' ion beams in storage rings by pushing cooling (to smooth out beam behaviour) to its limits, the final goal being to lock the ions into a neat crystal pattern. After advances by groups working on laser cooled ions in traps, and with several cooling rings now in operation, a workshop on crystalline ion beams was organized recently by the GSI (Darmstadt) Laboratory and held at Wertheim in Germany

  3. Magnet failure workshop

    Energy Technology Data Exchange (ETDEWEB)

    Marston, P G [Massachusetts Institute of Technology, Cambridge (U.S.A.); Desportes, H [C.E.N.-Saclay, 91 - Gif-sur-Yvette (France); Morpurgo, M [C.E.R.N., Geneva (Switzerland); Komarek, P [Kernforschungszentrum, Karlsruhe (Germany, FR); Van Hulst, K [University of Nijmegen (The Netherlands); Hackley, D [General Dynamics Convair, San Diego, CA (U.S.A.); Young, J L [Westinghouse Electric Corporation, East Pittsburgh, PE (U.S.A.); Kibbe, K [Oak Ridge National Laboratory (U.S.A.)

    1984-01-01

    The dictionary defines failure as nonperformance or an unacceptable want of success. (The definition implies that the results should have been avoided). In an emerging technology such as ours, the boundaries of expectations and ''unacceptable success'' are often ill defined. Failures are often touted as hugh successes (occasionally rightfully so) and exceptional technological achievement can become dismal failure (if expectations are too high). We all, however, have experienced problems of one sort or another and the basic purpose of the workshop was simply to communicate these so that new or future workers don't make the same mistakes.

  4. 15th Cluster workshop

    CERN Document Server

    Laakso, Harri; Escoubet, C. Philippe; The Cluster Active Archive : Studying the Earth’s Space Plasma Environment

    2010-01-01

    Since the year 2000 the ESA Cluster mission has been investigating the small-scale structures and processes of the Earth's plasma environment, such as those involved in the interaction between the solar wind and the magnetospheric plasma, in global magnetotail dynamics, in cross-tail currents, and in the formation and dynamics of the neutral line and of plasmoids. This book contains presentations made at the 15th Cluster workshop held in March 2008. It also presents several articles about the Cluster Active Archive and its datasets, a few overview papers on the Cluster mission, and articles reporting on scientific findings on the solar wind, the magnetosheath, the magnetopause and the magnetotail.

  5. High Field Workshop

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1984-12-15

    A Workshop was held in Frascati at the end of September under the title 'Generation of High Fields for Particle Acceleration to Very High Energies'. It was organized by the CERN Accelerator School, the European Committee for Future Accelerators (ECFA) and the Italian INFN and was a further stage in the exploratory moves towards new techniques of acceleration. Such techniques might become necessary to respond to the needs of high energy physics some decades from now when the application of conventional techniques will probably have reached their limits.

  6. Magnet failure workshop

    International Nuclear Information System (INIS)

    Marston, P.G.; Desportes, H.; Morpurgo, M.; Komarek, P.; Van Hulst, K.; Hackley, D.; Young, J.L.; Kibbe, K.

    1984-01-01

    The dictionary defines failure as nonperformance or an unacceptable want of success. (The definition implies that the results should have been avoided). In an emerging technology such as ours, the boundaries of expectations and ''unacceptable success'' are often ill defined. Failures are often touted as hugh successes (occasionally rightfully so) and exceptional technological achievement can become dismal failure (if expectations are too high). We all, however, have experienced problems of one sort or another and the basic purpose of the workshop was simply to communicate these so that new or future workers don't make the same mistakes

  7. SIMS applications workshop. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-04-01

    The first ANSTO/AINSE SIMS Workshop drew together a mixture of Surface Analysis experts and Surface Analysis users with the concept that SIMS analysis has to be enfolded within the spectrum of surface analysis techniques and that the user should select the technique most applicable to the problem. With this concept in mind the program was structured as sessions on SIMS Facilities; Applications to Mineral Surfaces; Applications to Biological Systems, Applications to Surfaces as Semi- conductors, Catalysts and Surface Coatings; and Applications to Ceramics

  8. Workshop on Cancer Research

    International Nuclear Information System (INIS)

    Vermorken, A.; Durieux, L.

    1991-01-01

    On April, 22-24 April 1991, the Hungarian National Institute of Oncology and the Commission of the European Communities have organized a workshop on Cancer Research. The aim of the meeting was to provide the participants information on the ongoing research in Hungary and in Member States. The topic is of importance for Hungary and it was also considered that the meeting could contribute to identify subjects of possible collaboration between Hungarian and Member State laboratories in the case financial support would become available. Three papers about new therapies under development were presented proton therapy and Boron neutron capture therapy

  9. WORKSHOP: Low temperature devices

    International Nuclear Information System (INIS)

    Anon.

    1987-01-01

    With extraterrestrial neutrinos (whether from the sun or further afield) continuing to make science news, and with the search for the so far invisible 'dark matter' of the universe a continual preoccupation, physicists from different walks of life (solid state, low temperature, particles, astrophysics) gathered at a workshop on low temperature devices for the detection of neutrinos and dark matter, held from 12-13 March at Ringberg Castle on Lake Tegernsee in the Bavarian Alps, and organized by the Max Planck Institute for Physics and Astrophysics in Munich

  10. WORKSHOP: Low temperature devices

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1987-06-15

    With extraterrestrial neutrinos (whether from the sun or further afield) continuing to make science news, and with the search for the so far invisible 'dark matter' of the universe a continual preoccupation, physicists from different walks of life (solid state, low temperature, particles, astrophysics) gathered at a workshop on low temperature devices for the detection of neutrinos and dark matter, held from 12-13 March at Ringberg Castle on Lake Tegernsee in the Bavarian Alps, and organized by the Max Planck Institute for Physics and Astrophysics in Munich.

  11. WORKSHOPS: Hadron facilities

    International Nuclear Information System (INIS)

    Anon.

    1987-01-01

    'Hadron facilities' – high intensity (typically a hundred microamps), medium energy (30-60 GeV) machines producing intense secondary beams of pions, kaons, etc., are being widely touted as a profitable research avenue to supplement what is learned through the thrust for higher and higher energies. This interest was reflected at an International Workshop on Hadron Facility Technology, held in Santa Fe, New Mexico. As well as invited talks describing the various projects being pushed in the US, Europe and Japan, the meeting included working groups covering linacs, beam dynamics, hardware, radiofrequency, polarized beams and experimental facilities

  12. Experimental halls workshop summary

    International Nuclear Information System (INIS)

    Thorndike, A.

    1976-01-01

    On May 26 and 27, 1976, approximately 50 people met for an informal workshop on plans for experimental halls for ISABELLE. Plans as they exist in the May 1976 version of the ISABELLE proposal were presented. Discussions were held on the following four general topics by separate working groups: (1) pros and cons of open areas as compared with enclosed halls; (2) experimental hall needs of ep, anti pp, and other options; (3) hall for the lepton detector; and (4) hall for the hadron spectrometer. The planning for experimental halls at PEP, the hall for the lepton detector, the hadron spectrometer, and open areas are discussed

  13. Workshop ''Radiooncology and law''

    International Nuclear Information System (INIS)

    Sack, H.; Deutsch, E.; Sauerwein, W.

    1998-01-01

    From 25 to 27 Sept 1997, a workshop was organized at the Essen Medical School (Universitaetsklinikum Essen), at which radiooncologists and jurists from universities and courts as well as lawyers contributed their views on mutual problems. The following topics were discussed by papers and in round table meetings: 'Requirements on the patient's information', 'definition of therapeutic guidelines - limits of clinical research and standard treatments', 'treatment documentation', 'liability of the physician for treatment faults' and 'technical standard and preserve of quality'. The consensual guidelines to the topics 'patient's information', 'therapeutic guidelines' and 'liability' are presented here. (orig.) [de

  14. Purpose of the workshop

    International Nuclear Information System (INIS)

    Brunner, H.

    1998-01-01

    The main purpose of the Workshop is to share the experience on emergency data management and to review various conceptual, technical, organisational and operational aspects and problems. The problems posed by hardware and software, the interplay of software developers and users/operators and the positive and negative experiences both from development and operation of data management systems are discussed. Emergency data management systems and their demonstrations are divided into four classes of possible applications: video games, training and simulation systems, 'history writing' = post-event analysis and documentation systems, real-time operational systems. (author)

  15. FASTBUS software workshop

    International Nuclear Information System (INIS)

    1985-01-01

    FASTBUS is a standard for modular high-speed data acquisition, data-processing and control, development for use in high-energy physics experiments incorporating different types of computers and microprocessors. This Workshop brought together users from different laboratories for a review of current software activities, using the standard both in experiments and for test equipment. There are also papers on interfacing and the present state of systems being developed for use in future LEP experiments. Also included is a discussion on the proposed revision of FASTBUS Standard Routines. (orig.)

  16. Singularity Theory and its Applications

    CERN Document Server

    Stewart, Ian; Mond, David; Montaldi, James

    1991-01-01

    A workshop on Singularities, Bifuraction and Dynamics was held at Warwick in July 1989, as part of a year-long symposium on Singularity Theory and its applications. The proceedings fall into two halves: Volume I mainly on connections with algebraic geometry and volume II on connections with dynamical systems theory, bifurcation theory and applications in the sciences. The papers are original research, stimulated by the symposium and workshop: All have been refereed and none will appear elsewhere. The main topic of volume II is new methods for the study of bifurcations in nonlinear dynamical systems, and applications of these.

  17. Exploring Programmatic Interoperability: Army Future Force Workshop

    National Research Council Canada - National Science Library

    Smith , II., James D; Meyers, B. C

    2005-01-01

    .... It describes the background and motivation for the workshop, provides a brief overview of the workshop activities, and highlights the key observations and conclusions obtained through the course...

  18. Educational Theory and Classroom Behavior.

    Science.gov (United States)

    Swanson, Ronald G.; Smith, William S.

    1979-01-01

    Described are two instruments used in a workshop designed to help teachers clarify their own beliefs about education and to shape their classroom behavior accordingly. The Student-Content Inventory concerns styles of student-teacher interaction and the Educational Theory Inventory correlates the respondent's beliefs to major educational theories.…

  19. Higher spin gauge theories

    CERN Document Server

    Henneaux, Marc; Vasiliev, Mikhail A

    2017-01-01

    Symmetries play a fundamental role in physics. Non-Abelian gauge symmetries are the symmetries behind theories for massless spin-1 particles, while the reparametrization symmetry is behind Einstein's gravity theory for massless spin-2 particles. In supersymmetric theories these particles can be connected also to massless fermionic particles. Does Nature stop at spin-2 or can there also be massless higher spin theories. In the past strong indications have been given that such theories do not exist. However, in recent times ways to evade those constraints have been found and higher spin gauge theories have been constructed. With the advent of the AdS/CFT duality correspondence even stronger indications have been given that higher spin gauge theories play an important role in fundamental physics. All these issues were discussed at an international workshop in Singapore in November 2015 where the leading scientists in the field participated. This volume presents an up-to-date, detailed overview of the theories i...

  20. Conference Report: Readings of Qualitative Research – Methods Workshop

    Directory of Open Access Journals (Sweden)

    Lisa Pfahl

    2004-05-01

    Full Text Available At the workshop, the relationship of poststructuralist and postmodernist social theory to the theoretical and methodological positions of interpretive sociology were discussed. A number of presentations contributed methodological reflections from biographical research and (Foucauldian discourse analysis; others discussed results of the application of discourse analysis and deconstruction in empirical research. All in all, it seems that (German biographical researchers have partly recognized and incorporated deconstructionist critique into their enquiries. The workshop has shown there is still a need for reflection on how poststructuralist strategies can inform empirical projects on a practical level. URN: urn:nbn:de:0114-fqs0402158

  1. 9th Workshop on Stochastic Analysis and Related Topics

    CERN Document Server

    Decreusefond, Laurent; Stochastic Analysis and Related Topics

    2012-01-01

    Since the early eighties, Ali Suleyman Ustunel has been one of the main contributors to the field of Malliavin calculus. In a workshop held in Paris, June 2010 several prominent researchers gave exciting talks in honor of his 60th birthday. The present volume includes scientific contributions from this workshop. Probability theory is first and foremost aimed at solving real-life problems containing randomness. Markov processes are one of the key tools for modeling that plays a vital part concerning such problems. Contributions on inventory control, mutation-selection in genetics and public-pri

  2. Hydrogen Technology Education Workshop Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    None

    2002-12-01

    This document outlines activities for educating key target audiences, as suggested by workshop participants. Held December 4-5, 2002, the Hydrogen Technology Education Workshop kicked off a new education effort coordinated by the Hydrogen, Fuel Cells, & Infrastructure Technologies Program of the Office of Energy Efficiency and Renewable Energy.

  3. A Portable Computer Security Workshop

    Science.gov (United States)

    Wagner, Paul J.; Phillips, Andrew T.

    2006-01-01

    We have developed a computer security workshop designed to instruct post-secondary instructors who want to start a course or laboratory exercise sequence in computer security. This workshop has also been used to provide computer security education to IT professionals and students. It is effective in communicating basic computer security principles…

  4. IFPA meeting 2008 workshops report

    DEFF Research Database (Denmark)

    Lash, G.E.; Ansari, T.; Bischof, P.

    2009-01-01

    Workshops are an important part of the IFPA annual meeting. At the IFPA meeting 2008 diverse topics were discussed in 12 themed workshops. Topics covered included: immunology of placentation; galectins and trophoblast invasion; signaling in implantation and invasion; markers to identify trophoblast...

  5. IFPA meeting 2009 workshops report

    DEFF Research Database (Denmark)

    Lash, G.E.; Burton, G.J.; Chamley, L.W.

    2010-01-01

    Workshops are an important part of the annual meeting of the International Federation of Placenta Associations (IFPA). At IFPA Meeting 2009 diverse topics were discussed in twelve themed workshops. Topics covered included: immune response to pregnancy; signaling between fetus and placenta...

  6. Workshop Polli Talu Loomingulises Keskuses

    Index Scriptorium Estoniae

    2004-01-01

    MAP Intermedia Performance Collaboration'i (USA) workshop. Brendan McCall (liikumine), N. B. Aldrich (heli) ja Zach Poff (video) workshop tutvustab kolme kunstniku koostööd. Näidatakse ka multimeedia etendust, mis on külaliskunstnikel valminud Polli talus

  7. A Workshop in Transcultural Nursing.

    Science.gov (United States)

    Stevenson, Thomas B.

    1986-01-01

    Describes an experimental, week-long interdisciplinary (i.e., nursing and anthropology) workshop on the relationship between health and culture conducted by Ohio University, Zanesville, in conjunction with the University of Toronto. Discusses program formulation, objectives, results, and suggestions for future workshops. (LAL)

  8. Special workshop on lung dosimetry

    International Nuclear Information System (INIS)

    Fisher, D.R.

    1983-01-01

    A Special Workshop on Lung Dosimetry was convened in Salt Lake City, Utah, on April 21-22, 1982, to stimulate the use of improved radiation dosimetry and to formulate a stronger basis for dose-response relationships for inhaled radionuclides. The two-day workshop was held in conjunction with the 30th Annual Meeting of the Radiation Research Society. Publication is planned

  9. Secondary School Design: Workshop Crafts.

    Science.gov (United States)

    Department of Education and Science, London (England).

    Design features are described for school shop facilities. Some general requirements common to most workshops are discussed; and specific design information is provided for general woodwork, general metalwork, and combined wood and metalwork facilities. The grouping of the workshop crafts and their relation to other parts of the school are also…

  10. AAAI Workshop on Nonmonotonic Reasoning

    OpenAIRE

    Etherington, David

    1985-01-01

    On October 17-19 1984 a workshop on non-monotonic reasoning was held at Mohonk Mountain House, outside New Paltz, New York. The workshop was organized by Raymond Reiter and Bonnie Webber, and was sponsored by the Association for the Advancement of Artificial Intelligence.

  11. Presentation Skills Workshops for Nurses.

    Science.gov (United States)

    Kinn, S.; Kenyon, M.

    2002-01-01

    Workshops were held to prepare nurses (n=87) to present results of professional activities. One year after the course, 20 had made oral and 30 written presentations. The workshops increased their confidence and were considered practical, informal, and nonthreatening. (Contains 31 references.) (SK)

  12. Beta Cell Workshop 2013 Kyoto

    DEFF Research Database (Denmark)

    Heller, R Scott; Madsen, Ole D; Nielsen, Jens Høiriis

    2013-01-01

    The very modern Kyoto International Conference Center provided the site for the 8th workshop on Beta cells on April 23-26, 2013. The preceding workshops were held in Boston, USA (1991); Kyoto, Japan (1994); Helsingør, Denmark (1997); Helsinki, Finland (2003); El Perello, Spain (2006); Peebles...

  13. Summary of experimental insertions workshop

    International Nuclear Information System (INIS)

    Sandweiss, J.; Month, M.

    1976-01-01

    An ISABELLE workshop of the summer 1976 series, which was held at Brookhaven August 16--20, focused on the design and utilization of the experimental insertions. The goals of the workshop are outlined, and a few general remarks about the results are presented

  14. The math excellence workshop

    International Nuclear Information System (INIS)

    Lasser, Susan J.S.; Snelsire, Robert W.

    1992-01-01

    This paper describes the first two years of the Clemson University College of Engineering's Math Excellence Workshop, a program administered by Westinghouse Electric Corporation, Savannah River Site, and funded by the Department of Energy. The objective of the program is to prepare minority students for technical/scientific study, with the goal of increasing minority retention in the College of Engineering, Twenty-three African American students, all of whom had been accepted into the College of Engineering Fall 1990 freshman class, took part in the first year of the program. The contract paid for room, board, tuition, fees, books, and supplies for the students to live on campus and take a precalculus math course. In addition, the students attended a special honors workshop designed to prepare them to study technical material effectively. Twenty of the 23 students earned As or Bs in the precalculus class. All participants indicated that they felt confident of their ability to succeed academically at Clemson. At the end of the session, twenty of the students were still planning to major in engineering. The program was repeated the following summer with 24 students from the 1991 freshman class. Twelve of the students earned A's or B's in the precalculus class. (author)

  15. The Astronomy Workshop

    Science.gov (United States)

    Hamilton, Douglas P.

    2012-05-01

    {\\bf The Astronomy Workshop} (http://janus.astro.umd.edu) is a collection of interactive online educational tools developed for use by students, educators, professional astronomers, and the general public. The more than 20 tools in the Astronomy workshop are rated for ease-of-use, and have been extensively tested in large university survey courses as well as more specialized classes for undergraduate majors and graduate students. Here we briefly describe a few of the available tools. {\\bf Solar Systems Visualizer}: The orbital motions of planets, moons, and asteroids in the Solar System as well as many of the planets in exoplanetary systems are animated at their correct relative speeds in accurate to-scale drawings. Zoom in from the chaotic outer satellite systems of the giant planets all the way to their innermost ring systems. {\\bf Solar System Calculators}: These tools calculate a user-defined mathematical expression simultaneously for all of the Solar System's planets (Planetary Calculator) or moons (Satellite Calculator). Key physical and orbital data are automatically accessed as needed. {\\bf Stellar Evolution}: The "Life of the Sun" tool animates the history of the Sun as a movie, showing students how the size and color of our star has evolved and will evolve over billions of years. In "Star Race," the user selects two stars of different masses and watches their evolution in a split-screeen format that emphasizes the great differences in stellar lifetimes and fates.

  16. Highlights of the Workshop

    Science.gov (United States)

    Noor, Ahmed K.

    1997-01-01

    Economic stresses are forcing many industries to reduce cost and time-to-market, and to insert emerging technologies into their products. Engineers are asked to design faster, ever more complex systems. Hence, there is a need for novel design paradigms and effective design tools to reduce the design and development times. Several computational tools and facilities have been developed to support the design process. Some of these are described in subsequent presentations. The focus of the workshop is on the computational tools and facilities which have high potential for use in future design environment for aerospace systems. The outline for the introductory remarks is given. First, the characteristics and design drivers for future aerospace systems are outlined; second, simulation-based design environment, and some of its key modules are described; third, the vision for the next-generation design environment being planned by NASA, the UVA ACT Center and JPL is presented. The anticipated major benefits of the planned environment are listed; fourth, some of the government-supported programs related to simulation-based design are listed; and fifth, the objectives and format of the workshop are presented.

  17. GammaWorkshops Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Ramebaeck, H. (ed.) (Swedish Defence Research Agency (Sweden)); Straalberg, E. (Institute for Energy Technology, Kjeller (Norway)); Klemola, S. (Radiation and Nuclear Safety Authority, STUK (Finland)); Nielsen, Sven P. (Technical Univ. of Denmark. Risoe National Lab. for Sustainable Energy, Roskilde (Denmark)); Palsson, S.E. (Icelandic Radiation Safety Authority (Iceland))

    2012-01-15

    Due to a sparse interaction during the last years between practioners in gamma ray spectrometry in the Nordic countries, a NKS activity was started in 2009. This GammaSem was focused on seminars relevant to gamma spectrometry. A follow up seminar was held in 2010. As an outcome of these activities it was suggested that the 2011 meeting should be focused on practical issues, e.g. different corrections needed in gamma spectrometric measurements. This three day's meeting, GammaWorkshops, was held in September at Risoe-DTU. Experts on different topics relevant for gamma spectrometric measurements were invited to the GammaWorkshops. The topics included efficiency transfer, true coincidence summing corrections, self-attenuation corrections, measurement of natural radionuclides (natural decay series), combined measurement uncertainty calculations, and detection limits. These topics covered both lectures and practical sessions. The practical sessions included demonstrations of tools for e.g. corrections and calculations of the above meantioned topics. (Author)

  18. The math excellence workshop

    Energy Technology Data Exchange (ETDEWEB)

    Lasser, Susan J.S.; Snelsire, Robert W [College of Engineering, Clemson University, Clemson, SC (United States)

    1992-07-01

    This paper describes the first two years of the Clemson University College of Engineering's Math Excellence Workshop, a program administered by Westinghouse Electric Corporation, Savannah River Site, and funded by the Department of Energy. The objective of the program is to prepare minority students for technical/scientific study, with the goal of increasing minority retention in the College of Engineering, Twenty-three African American students, all of whom had been accepted into the College of Engineering Fall 1990 freshman class, took part in the first year of the program. The contract paid for room, board, tuition, fees, books, and supplies for the students to live on campus and take a precalculus math course. In addition, the students attended a special honors workshop designed to prepare them to study technical material effectively. Twenty of the 23 students earned As or Bs in the precalculus class. All participants indicated that they felt confident of their ability to succeed academically at Clemson. At the end of the session, twenty of the students were still planning to major in engineering. The program was repeated the following summer with 24 students from the 1991 freshman class. Twelve of the students earned A's or B's in the precalculus class. (author)

  19. Workshop on Subcritical Neutron Production

    International Nuclear Information System (INIS)

    Walter Sadowski; Roald Sagdeev

    2006-01-01

    Executive Summary of the Workshop on Subcritical Neutron Production A workshop on Subcritical Neutron Production was sponsored by the East-West Center of the University of Maryland on October 11-13, 2004. The subject of the workshop was the application of subcritical neutrons to transmutation of actinides. The workshop was attended by members of the fission, accelerator and fusion communities. Papers on the state of development of neutron production by accelerators, fusion devices, and fission reactors were presented. Discussions were held on the potential of these technologies to solve the problems of spent nuclear waste storage and nuclear non-proliferation presented by current and future nuclear power reactors. A list of participants including their affiliation and their E-Mail addresses is attached. The workshop concluded that the technologies, presently available or under development, hold out the exciting possibility of improving the environmental quality and long term energy resources of nuclear power while strengthening proliferation resistance. The workshop participants agreed on the following statements. The workshop considered a number of technologies to deal with spent nuclear fuels and current actinide inventories. The conclusion was reached that substantial increase in nuclear power production will require that the issue of spent nuclear fuel be resolved. The Workshop concluded that 14 MeV fusion neutrons can be used to destroy nuclear reactor by-products, some of which would otherwise have to be stored for geologic periods of time. The production of 14 MeV neutrons is based on existing fusion technologies at different research institutions in several countries around the world. At the present time this technology is used to produce 14 MeV neutrons in JET. More development work will be required, however, to bring fusion technology to the level where it can be used for actinide burning on an industrial scale. The workshop concluded that the potential

  20. Report of the transition crossing mini-workshop

    International Nuclear Information System (INIS)

    Martin, P.; Chou, W.

    1996-07-01

    This was the first in a series of mini-workshops on high intensity, high brightness hadron beams. Twenty five people from CERN, KEK, BNL, Fermilab and University of Houston attended the workshop. The first day was a plenary session with nine presentations. On the second day, three working groups (WG) were formed: WG-I was on theory, simulation and measurements, led by J.P. Riunaud (CERN) and P.L. Colestock (Fermilab); WG-II was on γ t -jump systems, led by T. Roser (BNL) and W. Chou (Fermilab); WG-III was on new schemes, led by Y. Mori (KEK) and J. Griffin (Fermilab). Each group gave a presentation at the final plenary session. The summaries from the three working groups are included in this report. During the workshop, P. Martin gave a guided tour to the Main Injector tunnel, which is under construction at Fermilab

  1. CTBTO international cooperation workshop

    International Nuclear Information System (INIS)

    1999-01-01

    The International Cooperation Workshop took place in Vienna, Austria, on 16 and 17 November 1998, with the participation of 104 policy/decision makers, Research and Development managers and diplomatic representatives from 58 States Signatories to the Comprehensive Nuclear-Test Ban Treaty (CTBT). The Workshop attempted to develop Treaty stipulations to: promote cooperation to facilitate and participate in the fullest possible exchange relating to technologies used in the verification of the Treaty; enable member states to strengthen national implementation of verification measures, and to benefit from the application of such technologies for peaceful purposes. The potential benefits arising from the CTBT monitoring, analysis and data communication systems are multifaceted, and as yet unknown. This Workshop provided the opportunity to examine some of these possibilities. An overview of the CTBT verification regime on the general aspects of the four monitoring technologies (seismic, hydro-acoustic, infrasound and radionuclides), including some of the elements that are the subject of international cooperation, were presented and discussed. Questions were raised on the potential benefits that can be derived by participating in the CTBT regime and broad-based discussions took place. Several concrete proposals on ways and means to facilitate and promote cooperation among States Signatories were suggested. The main points discussed by the participants can be summarized as follows: the purpose of the CTBT Organization is to assist member states to monitor Treaty compliance; the CTBT can be a highly effective technological tool which can generate wide-ranging data, which can be used for peaceful purposes; there are differences in the levels of technology development in the member states that is why peaceful applications should be supported by the Prep Com for the benefit of all member states, whether developed or developing, training being a key element to optimize the CTBT

  2. The Third ATLAS ROD Workshop

    CERN Multimedia

    Poggioli, L.

    A new-style Workshop After two successful ATLAS ROD Workshops dedicated to the ROD hardware and held at the Geneva University in 1998 and in 2000, a new style Workshop took place at LAPP in Annecy on November 14-15, 2002. This time the Workshop was fully dedicated to the ROD-TDAQ integration and software in view of the near future integration activities of the final RODs for the detector assembly and commissioning. More precisely, the aim of this workshop was to get from the sub-detectors the parameters needed for T-DAQ, as well as status and plans from ROD builders. On the other hand, what was decided and assumed had to be stated (like EB decisions and URDs), and also support plans. The Workshop gathered about 70 participants from all ATLAS sub-detectors and the T-DAQ community. The quite dense agenda allowed nevertheless for many lively discussions, and for a dinner in the old town of Annecy. The Sessions The Workshop was organized in five main sessions: Assumptions and recommendations Sub-de...

  3. Exploring a Theory Describing the Physics of Information Systems, Characterizing the Phenomena of Complex Information Systems

    National Research Council Canada - National Science Library

    Harmon, Scott

    2001-01-01

    This project accomplished all of its objectives: document a theory of information physics, conduct a workshop on planing experiments to test this theory, and design experiments that validate this theory...

  4. WORKSHOP: Radiofrequency superconductivity

    International Nuclear Information System (INIS)

    Tückmantel, Joachim

    1993-01-01

    Full text: With superconducting radiofrequency playing a major role in the push for new machines to break fresh physics frontiers, it has become a tradition for experts and newcomers in this field from all over the world to meet every second year to hear progress reports from laboratories and to discuss common problems and possible solutions. The sixth such workshop was held from 4-8 October under the chairmanship of Ron Sundelin at the Continuous Electron Beam Accelerator Facility (CEBAF) under construction in Newport News, Virginia. With 170 participants from 14 countries including Eastern Europe and China, it reflected the growing interest in the field - looking back to 1984, when CERN was the host laboratory, the second workshop had less than 100 participants. The CEBAF meeting began with laboratory status reports, covering both high beam energy ('high beta') applications with 'spherical' cavities (as with CERN's LEP200), all using niobium as superconductor and working between 352 MHz and 3 GHz, and lower energy (low beta') applications with geometrically more complicated shapes such as quarter or half wave, split ring or spoke resonators, some using electrodeposited lead as superconductor and working around 100 MHz. During these talks it became clear that more and more laboratories have focused on routine problems, such as reliable series production and testing, running cavities with ancillaries in the machines, or building complete prototypes for projects to be approved by critical funding authorities. This contrasts with the heady days just a few years ago when - at least in the high beta community - the main objective was to explore new ideas. State-of-the-art summaries showed how at 1.3 and 3 GHz 25-30 MV/m have been reached by several laboratories using different preparation methods. Newer developments for common problems included r.f. windows, couplers, controls, and especially field emission, public enemy number one for

  5. NOMA 2013 International Workshop

    CERN Document Server

    Fournier-Prunaret, Danièle; Nishio, Yoshifumi; Grácio, Clara

    2015-01-01

    In the field of Dynamical Systems, nonlinear iterative processes play an important role. Nonlinear mappings can be found as immediate models for many systems from different scientific areas, such as engineering, economics, biology, or can also be obtained via numerical methods permitting to solve non-linear differential equations. In both cases, the understanding of specific dynamical behaviors and phenomena is of the greatest interest for scientists. This volume contains papers that were presented at the International Workshop on Nonlinear Maps and their Applications (NOMA 2013) held in Zaragoza, Spain, on September 3-4, 2013. This kind of collaborative effort is of paramount importance in promoting communication among the various groups that work in dynamical systems and networks in their research theoretical studies as well as for applications. This volume is suitable for graduate students as well as researchers in the field.

  6. Workshop on Computational Optimization

    CERN Document Server

    2016-01-01

    This volume is a comprehensive collection of extended contributions from the Workshop on Computational Optimization 2014, held at Warsaw, Poland, September 7-10, 2014. The book presents recent advances in computational optimization. The volume includes important real problems like parameter settings for controlling processes in bioreactor and other processes, resource constrained project scheduling, infection distribution, molecule distance geometry, quantum computing, real-time management and optimal control, bin packing, medical image processing, localization the abrupt atmospheric contamination source and so on. It shows how to develop algorithms for them based on new metaheuristic methods like evolutionary computation, ant colony optimization, constrain programming and others. This research demonstrates how some real-world problems arising in engineering, economics, medicine and other domains can be formulated as optimization tasks.

  7. Workshop on Computational Optimization

    CERN Document Server

    2015-01-01

    Our everyday life is unthinkable without optimization. We try to minimize our effort and to maximize the achieved profit. Many real world and industrial problems arising in engineering, economics, medicine and other domains can be formulated as optimization tasks. This volume is a comprehensive collection of extended contributions from the Workshop on Computational Optimization 2013. It presents recent advances in computational optimization. The volume includes important real life problems like parameter settings for controlling processes in bioreactor, resource constrained project scheduling, problems arising in transport services, error correcting codes, optimal system performance and energy consumption and so on. It shows how to develop algorithms for them based on new metaheuristic methods like evolutionary computation, ant colony optimization, constrain programming and others.

  8. Recombinational repair: workshop summary

    International Nuclear Information System (INIS)

    Howard-Flanders, P.

    1983-01-01

    Recombinational repair may or may not be synonymous with postreplication repair. Considerable progress has been made in the study of the relevant enzymes, particularly those from bacteria. In this workshop we focus on the recombination enzyme RecA protein. What structural changes take place in the protein and in DNA during repair. How does homologous pairing take place. How is ATP hydrolysis coupled to the stand exchange reaction and the formation of heteroduplx DNA. Turning to another enzyme needed for certain kinds of bacterial recombination, we will ask whether the purified recB protein and recC protein complement each other and are sufficient for exonuclease V activity. In higher cells, we would like to know whether sister exchanges, which occur in bacteria after uv irradiation, are also seen in animal cells

  9. Student interaction in workshops

    DEFF Research Database (Denmark)

    Evers, Winie

    2014-01-01

    A kind of teaching for active learning has been experimented with at SDU Sønderborg as part of the course Supply Chain Dynamics. In this course the students learn about complex systems, system dynamics as well as supply chain instability and oscillation, the course lecturer invited the author...... to experiment with novel workshop methods and techniques, where objects are used to illustrate and model business issues (Heinemann et al, 2011, Buur et al, 2013). The idea was to see how students could be engaged in a different and more interactive way to learn about these topics, by assigning the students...... teaching should reflect this diversity by embracing and experimenting with multiple forms, including activation of students by students’ interaction and manipulation with objects....

  10. 2016 MICCAI Workshop

    CERN Document Server

    Ghosh, Aurobrata; Kaden, Enrico; Rathi, Yogesh; Reisert, Marco

    2017-01-01

    This volume offers a valuable starting point for anyone interested in learning computational diffusion MRI and mathematical methods for brain connectivity, while also sharing new perspectives and insights on the latest research challenges for those currently working in the field. Over the last decade, interest in diffusion MRI has virtually exploded. The technique provides unique insights into the microstructure of living tissue and enables in-vivo connectivity mapping of the brain. Computational techniques are key to the continued success and development of diffusion MRI and to its widespread transfer into the clinic, while new processing methods are essential to addressing issues at each stage of the diffusion MRI pipeline: acquisition, reconstruction, modeling and model fitting, image processing, fiber tracking, connectivity mapping, visualization, group studies and inference. These papers from the 2016 MICCAI Workshop “Computational Diffusion MRI” – which was intended to provide a snapshot of the la...

  11. Workshop on Teaching Thermodynamics

    CERN Document Server

    1985-01-01

    It seemed appropriate to arrange a meeting of teachers of thermodynamics in the United Kingdom, a meeting held in the pleasant surroundings of Emmanuel College, Cambridge, in Sept~mber, 1984. This volume records the ideas put forward by authors, the discussion generated and an account of the action that discussion has initiated. Emphasis was placed on the Teaching of Thermodynamics to degree-level students in their first and second years. The meeting, a workshop for practitioners in which all were expected to take part, was remarkably well supported. This was notable in the representation of essentially every UK university and polytechnic engaged in teaching engineering thermodynamics and has led to a stimulating spread of ideas. By intention, the emphasis for attendance was put on teachers of engineering concerned with thermodynamics, both mechanical and chemical engineering disciplines. Attendance from others was encouraged but limited as follows: non-engineering acad­ emics, 10%, industrialists, 10%. The ...

  12. Workshop Econophys-2015

    CERN Document Server

    Aoyama, Hideaki; Chakrabarti, Bikas; Chakraborti, Anirban; Deo, Nivedita; Raina, Dhruv; Vodenska, Irena

    2017-01-01

    This book presents the proceedings from ECONOPHYS-2015, an international workshop held in New Delhi, India, on the interrelated fields of “econophysics” and “sociophysics”, which have emerged from the application of statistical physics to economics and sociology. Leading researchers from varied communities, including economists, sociologists, financial analysts, mathematicians, physicists, statisticians, and others, report on their recent work, discuss topical issues, and review the relevant contemporary literature. A society can be described as a group of people who inhabit the same geographical or social territory and are mutually involved through their shared participation in different aspects of life. It is possible to observe and characterize average behaviors of members of a society, an example being voting behavior. Moreover, the dynamic nature of interaction within any economic sector comprising numerous cooperatively interacting agents has many features in common with the interacting systems ...

  13. Signal sciences workshop proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Candy, J.V.

    1997-05-01

    This meeting is aimed primarily at signal processing and controls. The technical program for the 1997 Workshop includes a variety of efforts in the Signal Sciences with applications in the Microtechnology Area a new program at LLNL and a future area of application for both Signal/Image Sciences. Special sessions organized by various individuals in Seismic and Optical Signal Processing as well as Micro-Impulse Radar Processing highlight the program, while the speakers at the Signal Processing Applications session discuss various applications of signal processing/control to real world problems. For the more theoretical, a session on Signal Processing Algorithms was organized as well as for the more pragmatic, featuring a session on Real-Time Signal Processing.

  14. Signal sciences workshop. Proceedings

    International Nuclear Information System (INIS)

    Candy, J.V.

    1997-01-01

    This meeting is aimed primarily at signal processing and controls. The technical program for the 1997 Workshop includes a variety of efforts in the Signal Sciences with applications in the Microtechnology Area a new program at LLNL and a future area of application for both Signal/Image Sciences. Special sessions organized by various individuals in Seismic and Optical Signal Processing as well as Micro-Impulse Radar Processing highlight the program, while the speakers at the Signal Processing Applications session discuss various applications of signal processing/control to real world problems. For the more theoretical, a session on Signal Processing Algorithms was organized as well as for the more pragmatic, featuring a session on Real-Time Signal Processing

  15. 2014 MICCAI Workshop

    CERN Document Server

    Nedjati-Gilani, Gemma; Rathi, Yogesh; Reisert, Marco; Schneider, Torben

    2014-01-01

    This book contains papers presented at the 2014 MICCAI Workshop on Computational Diffusion MRI, CDMRI’14. Detailing new computational methods applied to diffusion magnetic resonance imaging data, it offers readers a snapshot of the current state of the art and covers a wide range of topics from fundamental theoretical work on mathematical modeling to the development and evaluation of robust algorithms and applications in neuroscientific studies and clinical practice.   Inside, readers will find information on brain network analysis, mathematical modeling for clinical applications, tissue microstructure imaging, super-resolution methods, signal reconstruction, visualization, and more. Contributions include both careful mathematical derivations and a large number of rich full-color visualizations.   Computational techniques are key to the continued success and development of diffusion MRI and to its widespread transfer into the clinic. This volume will offer a valuable starting point for anyone interested i...

  16. Workshop on Interface Phenomena

    CERN Document Server

    Kreuzer, Hans

    1987-01-01

    This book contains the proceedings of the first Workshop on Interface Phenomena, organized jointly by the surface science groups at Dalhousie University and the University of Maine. It was our intention to concentrate on just three topics related to the kinetics of interface reactions which, in our opinion, were frequently obscured unnecessarily in the literature and whose fundamental nature warranted an extensive discussion to help clarify the issues, very much in the spirit of the Discussions of the Faraday Society. Each session (day) saw two principal speakers expounding the different views; the session chairmen were asked to summarize the ensuing discussions. To understand the complexity of interface reactions, paradigms must be formulated to provide a framework for the interpretation of experimen­ tal data and for the construction of theoretical models. Phenomenological approaches have been based on a small number of rate equations for the concentrations or mole numbers of the various species involved i...

  17. 2015 Inverter Workshop | Photovoltaic Research | NREL

    Science.gov (United States)

    Inverter Workshop 2015 Inverter Workshop Wednesday, February 25, 2015 Chair: Jack Flicker In about inverters. This workshop represented a follow-on to the inverter workshops that Sandia National conversations between module and inverter experts. Agenda For a detailed schedule of the day's events, access

  18. Summary of the PSI workshop

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-03-01

    The PSI workshop had been held at JAERI-Naka, from March 15th to 16th, 2002. This workshop is held twice a year as the skull practice session to report the recent progress on the plasma - surface interactions of the experimental reactors such as ITER, JT-60, LHD, etc. and the development of the plasma facing components. There were 34 participants from the university and 18 participants from JAERI and 26 papers were presented. This booklet was published for the purpose of saving a record of this workshop performed in oral lecture form. (author)

  19. Reports on the 2015 AAAI Workshop Program

    OpenAIRE

    Albrecht, Stefano V.; Beck, J. Christopher; Buckeridge, David L.; Botea, Adi; Caragea, Cornelia; Chi, Chi-hung; Damoulas, Theodoros; Dilkina, Bistra; Eaton, Eric; Fazli, Pooyan; Ganzfried, Sam; Giles, C. Lee; Guillet, Sébastian; Holte, Robert; Hutter, Frank

    2015-01-01

    AAAI's 2015 Workshop Program was held Sunday and Monday, January 25–26, 2015 at the Hyatt Regency Austin Hotel in Austion, Texas, USA. The AAAI-15 workshop program included 15 workshops covering a wide range of topics in artificial intelligence. Most workshops were held on a single day. The titles of the workshops included AI and Ethics, AI for Cities, AI for Transportation: Advice, Interactivity and Actor Modeling, Algorithm Configuration, Artificial Intelligence Applied to Assistive Technol...

  20. Reports on the AAAI 1999 Workshop Program

    OpenAIRE

    Drabble, Brian; Chaudron, Laurent; Tessier, Catherine; Abu-Hakima, Sue; Willmott, Steven; Austin, Jim; Faltings, Boi; Freuder, Eugene C.; Friedrich, Gerhard; Freitas, Alex A.; Cortes, U.; Sanchez-Marre, M.; Aha, David W.; Becerra-Fernandez, Irma; Munoz-Avila, Hector

    2000-01-01

    The AAAI-99 Workshop Program (a part of the sixteenth national conference on artificial intelligence) was held in Orlando, Florida. The program included 16 workshops covering a wide range of topics in AI. Each workshop was limited to approximately 25 to 50 participants. Participation was by invitation from the workshop organizers. The workshops were Agent-Based Systems in the Business Context, Agents' Conflicts, Artificial Intelligence for Distributed Information Networking, Artificial Intell...

  1. 2014 WIN3 Workshop

    CERN Document Server

    Long, Ling; Pries, Rachel; Stange, Katherine

    2016-01-01

    Exploring the interplay between deep theory and intricate computation, this volume is a compilation of research and survey papers in number theory, written by members of the Women In Numbers (WIN) network, principally by the collaborative research groups formed at Women In Numbers 3, a conference at the Banff International Research Station in Banff, Alberta, on April 21-25, 2014. The papers span a wide range of research areas: arithmetic geometry; analytic number theory; algebraic number theory; and applications to coding and cryptography. The WIN conference series began in 2008, with the aim of strengthening the research careers of female number theorists. The series introduced a novel research-mentorship model: women at all career stages, from graduate students to senior members of the community, joined forces to work in focused research groups on cutting-edge projects designed and led by experienced researchers. The goals for Women In Numbers 3 were to establish ambitious new collaborations between women i...

  2. Proceedings of the Santa Fe workshop on electron effects

    International Nuclear Information System (INIS)

    Wang, T.S.; Jason, A.

    1998-01-01

    The Workshop was held under the sponsorship of the Spallation Neutron Source (SNS) Project to further project understanding of the effects and cause of the presence of electrons in proton accelerators. In particular, the fast instability seen in the Los Alamos Proton Storage Ring was the major topic of discussion since it limits the particles/pulse to the LANSCE target and could have an impact on the SNS Ring. This instability is believed due to the interaction of trapped electrons in the accumulated beam, i.e., an electron-proton or e-p instability. The first day of the workshop was occupied by invited talks that included a review of e-p instability theory, an overview of PSR observations, observations at other laboratories, reviews of electron-production mechanisms, theoretical studies on the PSR instability, and design issues of the SNS ring. For the second day, the workshop was organized into three working groups: a theory and computation group, a past-experiences and proposed-experiments group, and the SNS-design-strategy group. Their charter was to summarize previous work in their respective areas and to originate a course for future progress. The results of the working groups and the workshop were summarized in a joint session during the morning of the third day. These proceedings are a simple collection of the viewgraphs used as submitted to a member of the LANL secretarial staff by speakers

  3. Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine.

    Science.gov (United States)

    Narayana, N; Cox, S; Shaltiel, S; Taylor, S S; Xuong, N

    1997-04-15

    The crystal structure of the hexahistidine-tagged mouse recombinant catalytic subunit (H6-rC) of cAMP-dependent protein kinase (cAPK), complexed with a 20-residue peptide inhibitor from the heat-stable protein kinase inhibitor PKI(5-24) and adenosine, was determined at 2.2 A resolution. Novel crystallization conditions were required to grow the ternary complex crystals. The structure was refined to a final crystallographic R-factor of 18.2% with good stereochemical parameters. The "active" enzyme adopts a "closed" conformation as found in rC:PKI(5-24) [Knighton et al. (1991a,b) Science 253, 407-414, 414-420] and packs in a similar manner with the peptide providing a major contact surface. This structure clearly defines the subsites of the unique nucleotide binding site found in the protein kinase family. The adenosine occupies a mostly hydrophobic pocket at the base of the cleft between the two lobes and is completely buried. The missing triphosphate moiety of ATP is filled with a water molecule (Wtr 415) which replaces the gamma-phosphate of ATP. The glycine-rich loop between beta1 and beta2 helps to anchor the phosphates while the ribose ring is buried beneath beta-strand 2. Another ordered water molecule (Wtr 375) is pentacoordinated with polar atoms from adenosine, Leu 49 in beta-strand 1, Glu 127 in the linker strand between the two lobes, Tyr 330, and a third water molecule, Wtr 359. The conserved nucleotide fold can be defined as a lid comprised of beta-strand 1, the glycine-rich loop, and beta-strand 2. The adenine ring is buried beneath beta-strand 1 and the linker strand (120-127) that joins the small and large lobes. The C-terminal tail containing Tyr 330, a segment that lies outside the conserved core, covers this fold and anchors it in a closed conformation. The main-chain atoms of the flexible glycine-rich loop (residues 50-55) in the ATP binding domain have a mean B-factor of 41.4 A2. This loop is quite mobile, in striking contrast to the other

  4. Systematic Review Workshop (August 2013)

    Science.gov (United States)

    The goal for this workshop is to receive scientific input regarding approaches for different steps within a systematic review, such as evaluating individual studies, synthesizing evidence within a particular discipline, etc.

  5. Workshop on Developing Safe Software

    International Nuclear Information System (INIS)

    Lawrence, J.D.

    1994-11-01

    The Workshop on Developing Safe Software was held July 22--23, 1992, at the Hotel del Coronado, San Diego, California. The purpose of the workshop was to have four world experts discuss among themselves software safety issues which are of interest to the US Nuclear Regulatory Commission. These issues concern the development of software systems for use in nuclear power plant protection systems. The workshop comprised four sessions. Wednesday morning, July 22, consisted of presentations from each of the four panel members. On Wednesday afternoon, the panel members went through a list of possible software development techniques and commented on them. The Thursday morning, July 23, session consisted of an extended discussion among the panel members and the observers from the NRC. A final session on Thursday afternoon consisted of a discussion among the NRC observers as to what was learned from the workshop

  6. Workshop on developing safe software

    International Nuclear Information System (INIS)

    Lawrence, J.D.

    1992-01-01

    The Workshop on Developing Safe Software was held July 22--23 at the Hotel del Coronado, San Diego, California. The purpose of the workshop was to have four world experts discuss among themselves software safety issues which are of interest to the U. S. Nuclear Regulatory Commission (NRC). These issues concern the development of software systems for use in nuclear power plant protection systems. The workshop comprised four sessions. Wednesday morning, July 22, consisted of presentations from each of the four panel members. On Wednesday afternoon, the panel members went through a list of possible software development techniques and commented on them. The Thursday morning, July 23, session consisted of an extended discussion among the panel members and the observers from the NRC. A final session on Thursday afternoon consisted of a discussion among the NRC observers as to what was teamed from the workshop

  7. Stanford Workshop on Surgical Simulation

    National Research Council Canada - National Science Library

    Salisbury, Kenneth

    2001-01-01

    .... The goal of this workshop was to bring together researchers and developers from around the world who focus on modeling and simulation of deformable materials for applications requiring real-time interaction...

  8. Workshop on Language Student Attrition

    National Research Council Canada - National Science Library

    Whelan, Bree

    2001-01-01

    Seventy individuals from Government agencies (military and civilian), academia, and contractor organizations attended all or parts of a Workshop on student Attrition held at the Defense Language Institute Foreign Language Center (DLIFLC...

  9. Baltic Nuclear workshop. Final report

    International Nuclear Information System (INIS)

    Wahlberg, L.G.

    2001-05-01

    Proceedings of the NKS/BOK-1.6 workshop on crisis communication 'Baltic Nuclear', held in Stockholm March 19 -20, 2001, with participants from the nuclear power plants and nuclear authorities in the Baltic Sea region. The main content of the workshop was founded on the principle of 'learning by doing'. The participants were therefore practically trained in how to handle a crisis from an information and communication point of view. Added to that there were three different lectures. (au)

  10. 6th International Microbeam Workshop

    Energy Technology Data Exchange (ETDEWEB)

    Dr Kevin M. Prise

    2004-01-01

    The extended abstracts which are submitted here present a summary of the proceedings of the 6th International Workshop/12th LH Gray Workshop: Microbeam Probes of Cellular Radiation Response, held at St. Catherine's College, University of Oxford, UK on March, 29th-31st, 2003. In 1993 the 4th LH Gray Workshop entitled ''Microbeam Probes of Cellular Radiation Response'' was held at the Gray Cancer Institute in Northwood. This was organized by Prof BD Michael, Dr M. Folkard and Dr KM Prise and brought together 40 participants interested in developing and applying new microbeam technology to problems in radiation biology (1). The workshop was an undoubted success and has spawned a series of subsequent workshops every two years. In the past, these workshops have been highly successful in bringing together groups interested in developing and applying micro-irradiation techniques to the study of cell and tissue damage by ionizing radiations. Following the first microbeam workshop, there has been a rapid growth in the number of centres developing radiobiology microbeams, or planning to do so and there are currently 15-20 worldwide. Much of the recent research using microbeams has used them to study low-dose effects and ''non-targeted'' responses such bystander effects, genomic instability and adaptive responses. The goal of the 6th workshop was to build on our knowledge of the development of microbeam approaches and the application to radiation biology in the future with the meeting stretching over a 3 day period. Over 80 participants reviewed the current state of radiobiology microbeam research worldwide and reported on new technological developments both in the fields of physics and biology.

  11. Midwest Transmission Workshop II Summary

    Energy Technology Data Exchange (ETDEWEB)

    Kevin Bryan

    2002-12-05

    OAK-B135 After introductions of all participants, Abby Arnold, RESOLVE, reviewed the purpose of the meeting and the agenda. The purpose of the workshop was to share the results of the Midwest Independent System Operator (MISO) scenario development for wind and other fuel sources and the corresponding implications for transmission throughout the MISO control area. The workshop agenda is included in Attachment A.

  12. Cyber Mutual Assistance Workshop Report

    Science.gov (United States)

    2018-02-01

    Threat Intelligence 19 2.13 Industry Forums and Groups 20 2.14 Cybersecurity Vendors 20 3 Conclusions and Recommendations 22 Appendix A List of...establishing reliable situational awareness from an OT per- spective, from manual change analysis to machine learning or artificial intelligence . From a...dark web, or following cybersecurity -related news. Workshop members identified other threat intelligence collection sources during the workshop, which

  13. The AAAI-13 Conference Workshops

    OpenAIRE

    Agrawal, Vikas; Archibald, Christopher; Bhatt, Mehul; Bui, Hung; Cook, Diane J.; Cortés, Juan; Geib, Christopher; Gogate, Vibhav; Guesgen, Hans W.; Jannach, Dietmar; Johanson, Michael; Kersting, Kristian; Konidaris, George; Kotthoff, Lars; Michalowski, Martin

    2013-01-01

    The AAAI-13 Workshop Program, a part of the 27th AAAI Conference on Artificial Intelligence, was held Sunday and Monday, July 14–15, 2013 at the Hyatt Regency Bellevue Hotel in Bellevue, Washington, USA. The program included 12 workshops covering a wide range of topics in artificial intelligence, including Activity Context-Aware System Architectures (WS-13-05); Artificial Intelligence and Robotics Methods in Computational Biology (WS-13-06); Combining Constraint Solving with Mining and Lear...

  14. Women in Astronomy Workshop Report

    OpenAIRE

    Brough, Sarah; Bauer, Amanda E.; Brooks, Kate; Hopkins, Andrew; Maddison, Sarah

    2011-01-01

    Here we report on the Women in Astronomy Workshop (http://asawomeninastronomy.org/meetings/wia2011/), which was held on 13 May 2011 in Sydney, Australia. The workshop was organised by the Astronomical Society of Australia's Chapter on Women in Astronomy, to discuss some of the issues that face women in astronomy and make recommendations to help support the success of women in Australian astronomy but came to broader conclusions that have value for the whole astronomical community. The worksho...

  15. 3. Halden Reactor Project Workshop

    International Nuclear Information System (INIS)

    Louka, Michael N.

    2005-09-01

    A workshop was held in Halden 2nd-3rd March 2005 to discuss 'VR in the Future Industrial Workplace: Working Together - Regardless of Distance'. The workshop sessions and discussions focused on design, operations and maintenance, training, and engineering virtual reality systems, and provided useful insights into the current state of the art of research and development in the fields of virtual and augmented reality. (Author)

  16. Competitiveness Improvement Project Informational Workshop

    Energy Technology Data Exchange (ETDEWEB)

    Sinclair, Karin C [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Preus, Robert W [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Dana, Scott [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Van Dam, Jeroen J [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Damiani, Rick R [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Jackson, Kyndall R [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Baring-Gould, Edward I [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Jain, Anant [Intertek

    2018-02-27

    This presentation was given at the Competitiveness Improvement Project (CIP) Informational Workshop on December 6, 2017. Topics covered during the workshop include an overview of the CIP, past projects, scoring criteria, technical support opportunities, certification body requirements, standards applicable to distributed wind generators, information on the National Electric Code, certification testing requirements, test site requirements, National Environmental Policy Act, design review, levelized cost of energy, procurement/contracting, project management/deliverables, and outreach materials.

  17. N Reactor Lessons Learned workshop

    International Nuclear Information System (INIS)

    Heaberlin, S.W.

    1993-07-01

    This report describes a workshop designed to introduce participants to a process, or model, for adapting LWR Safety Standards and Analysis Methods for use on rector designs significantly different than LWR. The focus of the workshop is on the ''Lessons Learned'' from the multi-year experience in the operation of N Reactor and the efforts to adapt the safety standards developed for commercial light water reactors to a graphite moderated, water cooled, channel type reactor. It must be recognized that the objective of the workshop is to introduce the participants to the operation of a non-LWR in a LWR regulatory world. The total scope of this topic would take weeks to provide a through overview. The objective of this workshop is to provide an introduction and hopefully establish a means to develop a longer term dialogue for technical exchange. This report provides outline of the workshop, a proposed schedule of the workshop, and a description of the tasks will be required to achieve successful completion of the project

  18. Summary of the Workshop

    International Nuclear Information System (INIS)

    2012-01-01

    Key observations and messages for the program of work of the RK and M project The workshop delivered a large amount of information, ideas and visions, and a provided a fruitful forum for multidisciplinary reflection and discussion. Key observations and messages from the workshop are as follows: - The importance of having a common glossary is confirmed. - It is of interest to the project to better understand the contents of the current bibliography on RK and M. - Examples of memory loss and records misuse or misplacement exist both inside and outside the nuclear field. - The relationship between regulation and RK and M preservation for the long-term needs to be better understood. - RK and M preservation or loss and recovery scenarios can be constructed based on a wide range of future human-development hypotheses. - The relationship between RK and M preservation and safeguards needs further clarification. - National archives are a promising venue as one of the multiple approaches for long-term RK and M preservation. - Records management alone will not equip future generations to deal with long-term stores. - It is important to preserve not only technical records, but also records on the history of the program, including its siting within a community (metadata). - The interest in the history of the program should also be looked at from a heritage viewpoint. - Understanding the many ways that clues and records can be left in order that knowledge may be reconstituted by generations beyond those immediately succeeding us is important in this context. - In the same vein, while we must operate on the assumption that the intra-generational transmission chain continues to preserve RK and M, we have also to reach to farther-out generations directly in case the chain is broken. - The aim in reaching out to farther-out generations should be, as far as possible, that of informing them. - The set of data to be kept should be commensurate with the future need for the data and the

  19. Strategic Leaders Adapting to the Future Environment: Department of State Senior Leader Workshop. Volume 02-03

    National Research Council Canada - National Science Library

    Wimbish, Bill

    2003-01-01

    The purpose of the workshop was to provide participants an opportunity to first review and examine current strategic leadership theories and concepts and how the Army develops and trains its officer...

  20. GamifIR 2016 - SIGIR 2016 Workshop on Gamification for Information Retrieval

    OpenAIRE

    Meder, Michael; Hopfgartner, Frank; Kazai, Gabriella; Kruschwitz, Udo

    2016-01-01

    The third workshop on Gamification for Information Retrieval (GamifIR) took place on\\ud the 21th of July 2016 in conjunction with SIGIR 2016 in Pisa, Italy. It was the first GamifIR\\ud held in conjunction with the SIGIR, the first and second GamifIR workshops were both colocated\\ud with ECIR. The workshop program included one invited keynote presentation, seven\\ud paper presentations and a discussion session. The keynote presentation stated the necessity\\ud of proper theory for gamification d...

  1. Extended abstracts of the 12th JAERI workshop on high-Tc superconductors

    Energy Technology Data Exchange (ETDEWEB)

    Hojou, Kiichi; Okayasu, Satoru; Sasase, Masato [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Ishida, Takekazu [Osaka Prefectual Univ., Sakai (JP)] (eds.)

    2001-03-01

    This workshop was held on December 7-8, 2000 at JAERI (Tokai). The research group at JAERI shares a responsibility for material modification of high-Tc superconductors by irradiation in 'the multi-core project II of the high temperature superconducting material research' organized by STA (Science and Technology Agency) of Japan. This report contains the extended abstracts of workshop presentations covering basic theories, various experimental results and material improvement studies of the superconductivity by high energy ion irradiation. The twelve presentations of the workshop were devoted to a mini symposium where the direct observations of vortices were discussed in view of the various sophisticated techniques. (author)

  2. Workshop report on new directions in soft x-ray photoabsorption

    International Nuclear Information System (INIS)

    Bartlett, R.; Del Grande, N.K.; Lindau, I.; Manson, S.; Merts, A.L.; Pratt, R.

    1984-01-01

    The Workshop Report integrates what was said at the Workshop on New Directions in Soft X-Ray Photoabsorption, which focused on the region from 100 eV to 10 keV. The report clarifies the current state of theory and experiment and identifies the opportunities which new theoretical methods and experimental facilities could be expected to provide. The understanding of photoabsorption (which requires experimental photoabsorption cross section data) is a key to understanding the properties and behavior of atoms, molecules and solids. The Workshop participants were forty-three physicists and quantum chemists, from twenty-four institutions in four countries, all interested in photoabsorption from different perspectives

  3. Extended abstracts of the 12th JAERI workshop on high-Tc superconductors

    International Nuclear Information System (INIS)

    Hojou, Kiichi; Okayasu, Satoru; Sasase, Masato

    2001-03-01

    This workshop was held on December 7-8, 2000 at JAERI (Tokai). The research group at JAERI shares a responsibility for material modification of high-Tc superconductors by irradiation in 'the multi-core project II of the high temperature superconducting material research' organized by STA (Science and Technology Agency) of Japan. This report contains the extended abstracts of workshop presentations covering basic theories, various experimental results and material improvement studies of the superconductivity by high energy ion irradiation. The twelve presentations of the workshop were devoted to a mini symposium where the direct observations of vortices were discussed in view of the various sophisticated techniques. (author)

  4. Overview of the workshop

    International Nuclear Information System (INIS)

    Logsdon, Joe E.

    1989-01-01

    The Environmental Protection Agency (EPA) has the responsibility for development of Protective Action Guides (PAGs) except in the case of PAGs for food, the responsibility is shared with FDA. EPA participated in the development of the recommendations on PAGs for food and animal feed that FDA published in 1982. FDA is now in the process of revising their 1982 recommendations and we want to make every effort to assure that when their revisions are complete, we can concur and publish them in the PAG manual as EPA recommendations. Since USDA and States have the major role in the implementation of PAGs for water and food, we plan to closely coordinate the development process with them. This Workshop is designed as a forum for those who have experience in planning for and responding to ingestion exposure scenarios. The objective is to identify and discuss all of the issues, problems, relevant experiences, and needed or ongoing research that should be considered in the development of PAGs for water and food. Although the Federal agencies will not be able to resolve all of the identified issues and problems to everyone's satisfaction, it is expected that they will have at least considered them carefully and will be prepared to explain why they chose a particular approach or solution. This process should significantly reduce the need for changes to drafts of the guidance based on reviewer comments

  5. Workshop on environmental assessment

    International Nuclear Information System (INIS)

    Watson, E.C.

    1982-07-01

    Objectives of the workshop were: to review and evaluate the state-of-the-art of environmental impact assessments as applied to the regulation of applications of nuclear energy and related ancillary systems; to identify areas where existing technology allows establishing acceptable methods or standard practices that will meet the requirements of the NRC regulations, standards and guides for both normal operations and off-standard conditions including accident considerations; to illuminate topics where existing models or analytical methods are deficient because of unverified assumptions, a paucity of empirical data, conflicting results reported in the literature or a need for observation of operation systems; to compile, analyze and synthesize a prioritized set of research needs to advance the state-of-the-art to the level which will meet all of the requirements of the Commission's regulations, standards and guides; and to develop bases for maintaining the core of regulatory guidance at the optimum level balancing technical capabilities with practical considerations of cost and value to the regulatory process. The discussion held in small group sessions on aquatic, atmospheric, and terrestrial pathways are presented. The following research needs were identified as common to all three groups: validation of models; characterization of source terms; development of screening techniques; basis for de minimis levels of contamination; and updating of objectives for environmental monitoring programs

  6. Gas calorimeter workshop: proceedings

    International Nuclear Information System (INIS)

    1982-01-01

    Gas calorimeters combining functions of energy measurement and fine tracking have become more and more popular in the past few years. They help identify muons, gammas, electrons, and hadrons within dense tracks from transverse and longitudinal shower development. Fine segmentation capability using pads and strips on the cathodes have made gas-sampling calorimeters very attractive for colliding-beam detectors where a large multiplicity of particles are detected in a projected geometry. Linearity, energy resolution, shower position resolution, multishower resolution, and calibration questions were discussed in detail at the workshop. Ease of energy calibration by monitoring radioactive sources, good gain uniformity, and gain stability obtained were among the topics of the speakers. There was a discussion session on the operation mode of wire chambers. Gas calorimeters have been used successfully at CERN, Cornell, Fermilab, and SLAC for experiments. Some of the results from those large-scale devices were reported. Future usage of gas-sampling calorimeters for colliding-beam experiments at Fermilab and CERN were discussed. Wire chambers using extruded conductive plastic tubes have made construction easy of pads and strips which can conveniently read out induced signals from the cathode. The results of extensive studies on such devices were discussed. Separate entries were prepared for the data base for the 17 papers presented

  7. VLLEEM-2 technical workshop

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    In order to overcome the limits of the energy-environment models, and to benefit at the same time of their past experiences, the VLEEM project proposes a genuine approach and innovative modelling tools to assess the energy-environment systems over the very long term, which are based on the strengths of existing long term energy models, but focussed on two major objectives: to describe normative futures which fit with a set of overall constraints, like the stabilisation of the concentration of green-house gases in the atmosphere, or the stabilisation of the overall inventory of plutonium and minor actinides, etc...; to describe and formalize the association of causalities necessary to bring the system from the present situation to the targeted future, through a '' back-casting '' approach. This first technical workshop presents the state of the art of the different Work Programmes. WP1:Enhancement of the Conceptual framework. WP2: Data base on conventional demand/supply technologies. WP3: Complement and up-date technology monographs. WP4: Formalization and computing of final VLEEM submodels. WP5: Case study 2030, 2050, 2100. (A.L.B.)

  8. Proceedings of the Second international Workshop on Nuclear Data Evaluation for Reactor applications (Wonder 2009)

    International Nuclear Information System (INIS)

    2009-01-01

    The NEA (Nuclear Energy Agency) has collaborated with the CEA in the organization of the second international workshop on nuclear data evaluation for reactor applications: Wonder 2009. About 50 scientists have participated to the workshop and 38 presentations have been made, they have been organized around 4 sessions: 1) nuclear data measurements, 2) theory, modeling and evaluation of nuclear data, 3) uncertainties and covariance matrices, and 4) processing and validation of nuclear data

  9. Proceedings of the 6th International Workshop on Folk Music Analysis, 15-17 June, 2016

    OpenAIRE

    Beauguitte, Pierre; Duggan, Bryan; Kelleher, John

    2016-01-01

    The Folk Music Analysis Workshop brings together computational music analysis and ethnomusicology. Both symbolic and audio representations of music are considered, with a broad range of scientific approaches being applied (signal processing, graph theory, deep learning). The workshop features a range of interesting talks from international researchers in areas such as Indian classical music, Iranian singing, Ottoman-Turkish Makam music scores, Flamenco singing, Irish traditional music, Georgi...

  10. 21st Century Kinematics : The 2012 NSF Workshop

    CERN Document Server

    2013-01-01

    21st Century Kinematics focuses on algebraic problems in the analysis and synthesis of mechanisms and robots, compliant mechanisms, cable-driven systems and protein kinematics. The specialist contributors provide the background for a series of presentations at the 2012 NSF Workshop. The text shows how the analysis and design of innovative mechanical systems yield increasingly complex systems of polynomials, characteristic of those systems. In doing so, takes advantage of increasingly sophisticated computational tools developed for numerical algebraic geometry and demonstrates the now routine derivation of polynomial systems dwarfing the landmark problems of even the recent past. The 21st Century Kinematics workshop echoes the NSF-supported 1963 Yale Mechanisms Teachers Conference that taught a generation of university educators the fundamental principles of kinematic theory. As such these proceedings will be provide admirable supporting theory for a graduate course in modern kinematics and should be of consid...

  11. Holography demonstrations and workshops for science and engineering outreach

    Science.gov (United States)

    Thomas, Weston; Kruse, Kevin; Middlebrook, Christopher

    2012-10-01

    The SPIE/OSA Student Chapter at Michigan Technological University have developed demonstrations and workshops for science and engineering outreach. The practical approach to holography promotes the study of photonic related sciences in high school and college-aged students. An introduction to laser safety, optical laboratory practices, and basic laser coherence theory is given in order to first introduce the participants to the science behind the holograms. The students are then able to create a hologram of an item of their choice, personalizing the experience. By engaging directly, the students are able to see how the theory is applied and also enforces a higher level of attention from them so no mistakes are made in their hologram. Throughout the course participants gain an appreciation for photonics by learning how holograms operate and are constructed through hands on creation of their own holograms. This paper reviews the procedures and methods used in the demonstrations and workshop while examining the overall student experience.

  12. Workshop on high heat load x-ray optics

    International Nuclear Information System (INIS)

    1990-01-01

    A workshop on ''High Heat Load X-Ray Optics'' was held at Argonne National Laboratory on August 3--5, 1989. The object of this workshop was to discuss recent advances in the art of cooling x-ray optics subject to high heat loads from synchrotron beams. The cooling of the first optical element in the intense photon beams that will be produced in the next generation of synchrotron sources is recognized as one of the major challenges that must be faced before one will be able to use these very intense beams in future synchrotron experiments. Considerable advances have been made in this art during the last few years, but much work remains to be done before the heating problem can be said to be completely solved. Special emphasis was placed on recent cooling experiments and detailed ''finite element'' and ''finite difference'' calculations comparing experiment with theory and extending theory to optimize performance

  13. Workshop | Diversity in Language | 6 October

    CERN Multimedia

    2014-01-01

    The Diversity team, in collaboration with the Translation and Minutes group (DG-TM), has organised a workshop entitled “Rédiger en français sans exclure: questions de genre”, inviting us to think about the use of non-discriminatory language in French in terms of gender.   Natalie Garde, from the French Translation section, will give a presentation on the pragmatic solutions that the section has adopted, in an interactive workshop that will take place on Monday, 6 October, 2014 from 1.30 p.m. to 3.30 p.m. in Room 4-3-006 (Theory department auditorium). Language can exclude and also hide certain realities. Following a heightened awareness of this fact, new ways of using language that aim to make women more visible are beginning to appear. Sometimes, though, we can get a little lost. Should we say “une femme ingénieur” or “une ingénieure”, for example? Is it logical to speak of ...

  14. Proceedings of the First International Induced Gamma Emission Workshop

    International Nuclear Information System (INIS)

    Popescu, I.I.; Ur, C.A.

    1999-01-01

    The proceedings of the First International Induced Gamma Emission Workshop held on August 16-20, 1997 in Predeal, Romania contain 40 communications. These are bunched in the following 7 sections: 1. Opening session (8 papers); 2. Theory and Modelling (7 papers); 3. Pump Mechanisms (6 papers); 4. Pump Sources (3 papers); 5. Collective Effects (8 papers); 6. Nuclear Isomers (3 papers); 7. Moessbauer Effect (5 papers)

  15. The second workshop on phase separation with ordering

    International Nuclear Information System (INIS)

    Osamura, K.; Furusaka, M.

    1993-04-01

    The second workshop on phase separation with ordering was held at the seminar room of Booster, National Laboratory for High Energy Physics, KEK, Tsukuba, in March 16-17, 1992. 31 participants attended this meeting. The structure and its dynamical change were discussed mainly in the experimental viewpoint, and the theories have been developed and the results of simulation were reported. (J.P.N.) 115 refs

  16. Cell-cycle-dependent three-dimensional redistribution of nuclear proteins, P 120, pKi-67, and SC 35 splicing factor, in the presence of the topoisomerase I inhibitor camptothecin.

    Science.gov (United States)

    Elias, Emmanuel; Lalun, Nathalie; Lorenzato, Marianne; Blache, Laurent; Chelidze, Pavel; O'Donohue, Marie-Françoise; Ploton, Dominique; Bobichon, Hélène

    2003-11-15

    Topoisomerase I (Topo I) is mostly known for its role in DNA relaxation, which is required for duplication and transcription. Topo I acts as a protein kinase mainly directed to the mRNA splicing factor SC35. Camptothecin is one of the specific Topo I inhibitors and is effective on the two functions of the enzyme. In this study we demonstrated that treatment of KB cells with camptothecin for only 30 min induced the 3D reorganization and redistribution of three proteins involved in the nucleus machinery, P 120, pKi-67, and SC 35, and this occurred in a cell cycle-dependent manner. Our data were obtained from confocal microscopic studies after immunolabeling, 3D reconstruction, and measurement of the nuclear components volumes. In the presence of camptothecin, P 120, which occupied the nucleolar volume, lost its reticulation and pKi-67 was redistributed within the nucleoplasm and even into the cytoplasm. Finally, for SC 35 the fusion of its dots into bigger volumes was observed specifically during the G1 phase. Variations of volumes were also observed for the nucleolus and for the nucleus. These results pointed out that, depending on the cell cycle phase, Topo I functions were selective toward the three different proteins.

  17. Establishment and antitumor effects of dasatinib and PKI-587 in BD-138T, a patient-derived muscle invasive bladder cancer preclinical platform with concomitant EGFR amplification and PTEN deletion.

    Science.gov (United States)

    Chang, Nakho; Lee, Hye Won; Lim, Joung Eun; Jeong, Da Eun; Song, Hye Jin; Kim, Sudong; Nam, Do-Hyun; Sung, Hyun Hwan; Jeong, Byong Chang; Seo, Seong Il; Jeon, Seong Soo; Lee, Hyun Moo; Choi, Han-Yong; Jeon, Hwang Gyun

    2016-08-09

    Muscle-invasive bladder cancer (MIBC) consists of a heterogeneous group of tumors with a high rate of metastasis and mortality. To facilitate the in-depth investigation and validation of tailored strategies for MIBC treatment, we have developed an integrated approach using advanced high-throughput drug screening and a clinically relevant patient-derived preclinical platform. We isolated patient-derived tumor cells (PDCs) from a rare MIBC case (BD-138T) that harbors concomitant epidermal growth factor receptor (EGFR) amplification and phosphatase and tensin homolog (PTEN) deletion. High-throughput in vitro drug screening demonstrated that dasatinib, a SRC inhibitor, and PKI-587, a dual PI3K/mTOR inhibitor, exhibited targeted anti-proliferative and pro-apoptotic effects against BD-138T PDCs. Using established patient-derived xenograft models that successfully retain the genomic and molecular characteristics of the parental tumor, we confirmed that these anti-tumor responses occurred through the inhibition of SRC and PI3K/AKT/mTOR signaling pathways. Taken together, these experimental results demonstrate that dasatinib and PKI-587 might serve as promising anticancer drug candidates for treating MIBC with combined EGFR gene amplification and PTEN deletion.

  18. Summary of the ECLOUD'04 Workshop

    International Nuclear Information System (INIS)

    Macek, R.; Furman, M.

    2004-01-01

    The 31st ICFA Advanced Beam Dynamics Workshop on Electron-Cloud Effects ''ECLOUD'04'' was held April 19-23, 2004 at Napa, CA, USA. A broad range of current topics in this field were illuminated by 53 talks in 7 sessions plus 6 session summaries at the final summary session. These covered a variety of experimental methods and results, along with progress on understanding of the topic obtained from simulations and analytic theory, and evaluations of the effectiveness of various methods/mechanisms for mitigation of the adverse impact on accelerator performance. In addition, a panel discussion was held on ''Future Needs and Future Directions''. A summary of progress on the major themes covered at ECLOUD'04 is presented

  19. Second International workshop Geometry and Symbolic Computation

    CERN Document Server

    Walczak, Paweł; Geometry and its Applications

    2014-01-01

    This volume has been divided into two parts: Geometry and Applications. The geometry portion of the book relates primarily to geometric flows, laminations, integral formulae, geometry of vector fields on Lie groups, and osculation; the articles in the applications portion concern some particular problems of the theory of dynamical systems, including mathematical problems of liquid flows and a study of cycles for non-dynamical systems. This Work is based on the second international workshop entitled "Geometry and Symbolic Computations," held on May 15-18, 2013 at the University of Haifa and is dedicated to modeling (using symbolic calculations) in differential geometry and its applications in fields such as computer science, tomography, and mechanics. It is intended to create a forum for students and researchers in pure and applied geometry to promote discussion of modern state-of-the-art in geometric modeling using symbolic programs such as Maple™ and Mathematica®, as well as presentation of new results. ...

  20. Workshop on Analytical Methods in Statistics

    CERN Document Server

    Jurečková, Jana; Maciak, Matúš; Pešta, Michal

    2017-01-01

    This volume collects authoritative contributions on analytical methods and mathematical statistics. The methods presented include resampling techniques; the minimization of divergence; estimation theory and regression, eventually under shape or other constraints or long memory; and iterative approximations when the optimal solution is difficult to achieve. It also investigates probability distributions with respect to their stability, heavy-tailness, Fisher information and other aspects, both asymptotically and non-asymptotically. The book not only presents the latest mathematical and statistical methods and their extensions, but also offers solutions to real-world problems including option pricing. The selected, peer-reviewed contributions were originally presented at the workshop on Analytical Methods in Statistics, AMISTAT 2015, held in Prague, Czech Republic, November 10-13, 2015.

  1. 8th Workshop on Coupled Descriptor Systems

    CERN Document Server

    Bartel, Andreas; Günther, Michael; Maten, E; Müller, Peter

    2014-01-01

    This book contains the proceedings of the 8th Workshop on Coupled Descriptor Systems held March 2013 in the Castle of Eringerfeld, Geseke in the neighborhood of Paderborn, Germany. It examines the wide range of current research topics in descriptor systems, including mathematical modeling, index analysis, wellposedness of problems, stiffness and different time-scales, cosimulation and splitting methods and convergence analysis. In addition, the book also presents applications from the automotive and circuit industries that show that descriptor systems provide challenging problems from the point of view of both theory and practice.   The book contains nine papers and is organized into three parts: control, simulation, and model order reduction. It will serve as an ideal resource for applied mathematicians and engineers, in particular those from mechanics and electromagnetics, who work with coupled differential equations.

  2. Physics Analysis Tools Workshop Report

    CERN Multimedia

    Assamagan, K A

    A Physics Analysis Tools (PAT) workshop was held at the University of Tokyo in Tokyo Japan on May 15-19, 2006. Unlike the previous ones, this workshop brought together the core PAT developers and ATLAS users. The workshop was attended by 69 people from various institutions: Australia 5 Canada 1 China 6 CERN 4 Europe 7 Japan 32 Taiwan 3 USA 11 The agenda consisted of a 2-day tutorial for users, a 0.5-day user feedback discussion session between users and developers, and a 2-day core PAT workshop devoted to issues in Physics Analysis Tools activities. The tutorial, attended by users and developers, covered the following grounds: Event Selection with the TAG Event Selection Using the Athena-Aware NTuple Event Display Interactive Analysis within ATHENA Distributed Analysis Monte Carlo Truth Tools Trigger-Aware Analysis Event View By many accounts, the tutorial was useful. This workshop was the first time that the ATLAS Asia-Pacific community (Taiwan, Japan, China and Australia) go...

  3. Applications of ion beam analysis workshop. Workshop handbook

    International Nuclear Information System (INIS)

    1995-01-01

    A workshop on applications of ion beam analysis was held at ANSTO, immediate prior to the IBMM-95 Conference in Canberra. It aims was to review developments and current status on use of ion beams for analysis, emphasizing the following aspects: fundamental ion beam research and secondary effects of ion beams; material sciences, geological, life sciences, environmental and industrial applications; computing codes for use in accelerator research; high energy heavy ion scattering and recoil; recent technological development using ion beams. The handbook contains the workshop's program, 29 abstracts and a list of participants

  4. The Application of Motivational Theories to Business and Industry.

    Science.gov (United States)

    Clements, Paul; Farrar, Lochia A.

    This workshop, designed to use motivational theories in understanding work behaviors and to increase job satisfaction and performance, deals with cognitive theories in motivation, need theories, and the Equity Theory within the Expectancy Valence Model. Counseling technique areas of communication skills and rational thinking that facilitate the…

  5. WORKSHOP QCD at 20

    International Nuclear Information System (INIS)

    Nachtmann, O.

    1992-01-01

    The modern theory of strong interactions - Quantum Chromodynamics (QCD), where quarks and gluons carrying the 'colour' quantum number play the essential role, is twenty years old. This birthday was duly celebrated at RWTH Aachen from 9-13 June, where recurring themes were - what has been achieved in the past twenty years?, where do we stand?, and what are the perspectives for the future?

  6. Extreme Conditions Modeling Workshop Report

    Energy Technology Data Exchange (ETDEWEB)

    Coe, Ryan Geoffrey [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Neary, Vincent Sinclair [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Lawon, Michael J. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Yu, Yi-Hsiang [National Renewable Energy Lab. (NREL), Golden, CO (United States); Weber, Jochem [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2014-07-01

    Sandia National Laboratories (SNL) and the National Renewable Energy Laboratory (NREL) hosted the Wave Energy Converter (WEC) Extreme Conditions Modeling (ECM) Workshop in Albuquerque, New Mexico on May 13–14, 2014. The objective of the workshop was to review the current state of knowledge on how to numerically and experimentally model WECs in extreme conditions (e.g. large ocean storms) and to suggest how national laboratory resources could be used to improve ECM methods for the benefit of the wave energy industry. More than 30 U.S. and European WEC experts from industry, academia, and national research institutes attended the workshop, which consisted of presentations from W EC developers, invited keynote presentations from subject matter experts, breakout sessions, and a final plenary session .

  7. Workshop on the RHIC performance

    Energy Technology Data Exchange (ETDEWEB)

    Khiari, F.; Milutinovic, J.; Ratti, A.; Rhoades-Brown, M.J. (eds.)

    1988-07-01

    The most recent conceptual design manual for the Relativistic Heavy Ion Collider (RHIC) at Brookhaven was published in May 1986 (BNL 51932). The purpose of this workshop was to review the design specifications in this RHIC reference manual, and to discuss in detail possible improvements in machine performance by addressing four main areas. These areas are beam-beam interactions, stochastic cooling, rf and bunch instabilities. The contents of this proceedings are as follows. Following an overview of the workshop, in which the motivation and goals are discussed in detail, transcripts of the first day talks are given. Many of these transcripts are copies of the original transparencies presented at the meeting. The following four sections contain contributed papers, that resulted from discussions at the workshop within each of the four working groups. In addition, there is a group summary for each of the four working groups at the beginning of each section. Finally, a list of participants is given.

  8. Waterloo Workshop on Computer Algebra

    CERN Document Server

    Zima, Eugene; WWCA-2016; Advances in computer algebra : in honour of Sergei Abramov's' 70th birthday

    2018-01-01

    This book discusses the latest advances in algorithms for symbolic summation, factorization, symbolic-numeric linear algebra and linear functional equations. It presents a collection of papers on original research topics from the Waterloo Workshop on Computer Algebra (WWCA-2016), a satellite workshop of the International Symposium on Symbolic and Algebraic Computation (ISSAC’2016), which was held at Wilfrid Laurier University (Waterloo, Ontario, Canada) on July 23–24, 2016.   This workshop and the resulting book celebrate the 70th birthday of Sergei Abramov (Dorodnicyn Computing Centre of the Russian Academy of Sciences, Moscow), whose highly regarded and inspirational contributions to symbolic methods have become a crucial benchmark of computer algebra and have been broadly adopted by many Computer Algebra systems.

  9. Cleanroom Energy Efficiency Workshop Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Tschudi, Bill

    1999-03-15

    On March 15, 1999, Lawrence Berkeley National Laboratory hosted a workshop focused on energy efficiency in Cleanroom facilities. The workshop was held as part of a multiyear effort sponsored by the California Institute for Energy Efficiency, and the California Energy Commission. It is part of a project that concentrates on improving energy efficiency in Laboratory type facilities including cleanrooms. The project targets the broad market of laboratory and cleanroom facilities, and thus cross-cuts many different industries and institutions. This workshop was intended to raise awareness by sharing case study success stories, providing a forum for industry networking on energy issues, contributing LBNL expertise in research to date, determining barriers to implementation and possible solutions, and soliciting input for further research.

  10. Photovoltaic performance and reliability workshop

    Energy Technology Data Exchange (ETDEWEB)

    Mrig, L. [ed.

    1993-12-01

    This workshop was the sixth in a series of workshops sponsored by NREL/DOE under the general subject of photovoltaic testing and reliability during the period 1986--1993. PV performance and PV reliability are at least as important as PV cost, if not more. In the US, PV manufacturers, DOE laboratories, electric utilities, and others are engaged in the photovoltaic reliability research and testing. This group of researchers and others interested in the field were brought together to exchange the technical knowledge and field experience as related to current information in this evolving field of PV reliability. The papers presented here reflect this effort since the last workshop held in September, 1992. The topics covered include: cell and module characterization, module and system testing, durability and reliability, system field experience, and standards and codes.

  11. H2@Scale Workshop Report

    Energy Technology Data Exchange (ETDEWEB)

    Pivovar, Bryan

    2017-03-31

    Final report from the H2@Scale Workshop held November 16-17, 2016, at the National Renewable Energy Laboratory in Golden, Colorado. The U.S. Department of Energy's National Renewable Energy Laboratory hosted a technology workshop to identify the current barriers and research needs of the H2@Scale concept. H2@Scale is a concept regarding the potential for wide-scale impact of hydrogen produced from diverse domestic resources to enhance U.S. energy security and enable growth of innovative technologies and domestic industries. Feedback received from a diverse set of stakeholders at the workshop will guide the development of an H2@Scale roadmap for research, development, and early stage demonstration activities that can enable hydrogen as an energy carrier at a national scale.

  12. Li'l Red Schoolhouse workshops

    Science.gov (United States)

    1993-01-01

    Education specialists at Stennis conduct staff development workshops for elementary and secondary teachers of math, science and technology and other subjects as well as specialized workshops conducted in the NASA Li'l Red Schoolhouse.

  13. 78 FR 33849 - Battery-Powered Medical Devices Workshop: Challenges and Opportunities; Public Workshop; Request...

    Science.gov (United States)

    2013-06-05

    ... after the public workshop on the Internet at http://www.fda.gov/MedicalDevices/NewsEvents/Workshops..., compact, and mobile, the number of battery-powered medical devices will continue to increase. While many...] Battery-Powered Medical Devices Workshop: Challenges and Opportunities; Public Workshop; Request for...

  14. A policy model to initiate environmental negotiations: Three hydropower workshops

    Science.gov (United States)

    Lamb, Berton Lee; Taylor, Jonathan G.; Burkardt, Nina; Ponds, Phadrea D.

    1998-01-01

    How do I get started in natural resource negotiations? Natural resource managers often face difficult negotiations when they implement laws and policies regulating such resources as water, wildlife, wetlands, endangered species, and recreation. As a result of these negotiations, managers must establish rules, grant permits, or create management plans. The Legal‐Institutional Analysis Model (LIAM) was designed to assist managers in systematically analyzing the parties in natural resource negotiations and using that analysis to prepare for bargaining. The LIAM relies on the theory that organizations consistently employ behavioral roles. The model uses those roles to predict likely negotiation behavior. One practical use of the LIAM is when all parties to a negotiation conduct a workshop as a way to open the bargaining on a note of trust and mutual understanding. The process and results of three LIAM workshops designed to guide hydroelectric power licensing negotiations are presented. Our experience with these workshops led us to conclude that the LIAM can be an effective tool to begin a negotiation and that trust built through the workshops can help create a successful result.

  15. Antibullying workshops: shaping minority nursing leaders through curriculum innovation.

    Science.gov (United States)

    Egues, Aida L; Leinung, Elaine Z

    2014-01-01

    Bullying is a phenomenon that threatens nurse recruitment and retention. As such, nurse educators should be called upon to innovatively create ethical and safe informative and practice spaces for the development and socialization of future practicing nurses. Creation of such spaces would be especially important for learners of minority background needed to help care for our nation's growing populations. A variety of theory-driven strategies were employed to construct innovative workshops as part of teaching methodology for undergraduate nursing curriculum at a designated Hispanic- and minority-serving college. Nursing faculty provided the workshops in concert with mentored nursing student scholars who were likewise interested in bullying cessation. Surveys from 230 nursing student participants in workshops revealed a 10-33% increase in self-reported identification of various facets of the bullying phenomenon. Students' narrative reflections revealed personal experiences with bullying, a raised awareness of its phenomenon, and an improved dedication to ending bullying. Nurse educators can help influence antibullying awareness through workshops integrated into their program of study. This innovative curriculum strategy demonstrates nurse educator commitment to antibullying that is focused on guiding and promoting the advocacy of educational, leadership, and professional opportunities and skills growth for minority nursing student scholars. © 2014 Wiley Periodicals, Inc.

  16. Physics beyond Colliders Kickoff Workshop

    CERN Document Server

    2016-01-01

    The aim of the workshop is to explore the opportunities offered by the CERN accelerator complex and infrastructure to get new insights into some of today's outstanding questions in particle physics through projects complementary to high-energy colliders and other initiatives in the world. The focus is on fundamental physics questions that are similar in spirit to those addressed by high-energy colliders, but that may require different types of experiments. The kickoff workshop is intended to stimulate new ideas for such projects, for which we encourage the submission of abstracts.

  17. Workshop on Physics Beyond Colliders

    CERN Document Server

    2016-01-01

    The aim of the workshop is to explore the opportunities offered by the CERN accelerator complex and infrastructure to get new insights into some of today's outstanding questions in particle physics through projects complementary to high-energy colliders and other initiatives in the world. The focus is on fundamental physics questions that are similar in spirit to those addressed by high-energy colliders, but that may require different types of experiments. The kick-off workshop is intended to stimulate new ideas for such projects, for which we encourage the submission of abstracts.

  18. Workshop on momentum distributions: Summary

    International Nuclear Information System (INIS)

    Simmons, R.O.

    1988-01-01

    This has been an extraordinary Workshop touching many branches of physics. The Workshop has treated momentum distributions in fluid and solid condensed matter, in nuclei, and in electronic systems. Both theoretical and experimental concepts and methods have been considered in all these branches. A variety of specific illustrations and applications in physical systems have been presented. One finds that some common unifying themes emerge. One finds, also, that some examples are available to illustrate where one branch is more mature than others and to contrast where expectations for future progress may be most encouraged. 6 refs., 2 figs

  19. 1993 Radiation Protection Workshop: Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    1993-12-31

    The 1993 DOE Radiation Protection Workshop was conducted from April 13 through 15, 1993 in Las Vegas, Nevada. Over 400 Department of Energy Headquarters and Field personnel and contractors from the DOE radiological protection community attended the Workshop. Forty-nine papers were presented in eleven separate sessions: Radiological Control Manual Implementation, New Approaches to Instrumentation and Calibration, Radiological Training Programs and Initiatives, External Dosimetry, Internal Dosimetry, Radiation Exposure Reporting and Recordkeeping, Air Sampling and Monitoring Issues, Decontamination and Decommissioning of Sites, Contamination Monitoring and Control, ALARA/Radiological Engineering, and Current and Future Health Physics Research. Individual papers are indexed separately on the database.

  20. 1993 Radiation Protection Workshop: Proceedings

    International Nuclear Information System (INIS)

    1993-01-01

    The 1993 DOE Radiation Protection Workshop was conducted from April 13 through 15, 1993 in Las Vegas, Nevada. Over 400 Department of Energy Headquarters and Field personnel and contractors from the DOE radiological protection community attended the Workshop. Forty-nine papers were presented in eleven separate sessions: Radiological Control Manual Implementation, New Approaches to Instrumentation and Calibration, Radiological Training Programs and Initiatives, External Dosimetry, Internal Dosimetry, Radiation Exposure Reporting and Recordkeeping, Air Sampling and Monitoring Issues, Decontamination and Decommissioning of Sites, Contamination Monitoring and Control, ALARA/Radiological Engineering, and Current and Future Health Physics Research. Individual papers are indexed separately on the database

  1. Extreme Conditions Modeling Workshop Report

    Energy Technology Data Exchange (ETDEWEB)

    Coe, R. G.; Neary, V. S.; Lawson, M. J.; Yu, Y.; Weber, J.

    2014-07-01

    Sandia National Laboratories (SNL) and the National Renewable Energy Laboratory (NREL) hosted the Wave Energy Converter (WEC) Extreme Conditions Modeling (ECM) Workshop in Albuquerque, NM on May 13th-14th, 2014. The objective of the workshop was to review the current state of knowledge on how to model WECs in extreme conditions (e.g. hurricanes and other large storms) and to suggest how U.S. Department of Energy (DOE) and national laboratory resources could be used to improve ECM methods for the benefit of the wave energy industry.

  2. Summary of experimental insertions workshop

    International Nuclear Information System (INIS)

    Sandweiss, J.; Month, M.

    1976-01-01

    The last ISABELLE workshop of the summer 1976 series, which was held at Brookhaven, August 16-20, focused on the design and utilization of the experimental insertions. The goals of the workshop, which were somewhat more general than might be suggested by the title, are: (1) review the ISABELLE proposal from the point of view of experimental use; (2) contribute useful information on the ''open questions'' in the ISABELLE design; (3) develop data for experimental equipment and operating cost estimates; and (4) project a first approximation to ISABELLE operating modes

  3. International workshop on multimodal virtual and augmented reality (workshop summary)

    NARCIS (Netherlands)

    Hürst, W.O.; Iwai, Daisuke; Balakrishnan, Prabhakaran

    2016-01-01

    Virtual reality (VR) and augmented reality (AR) are expected by many to become the next wave of computing with significant impacts on our daily lives. Motivated by this, we organized a workshop on “Multimodal Virtual and Augmented Reality (MVAR)” at the 18th ACM International Conference on

  4. International cooperation workshop. Regional workshop for CTBTO international cooperation: Africa

    International Nuclear Information System (INIS)

    1999-08-01

    Pursuant to the 1999 programme of work, and following the International Cooperation Workshop held in Vienna, Austria, in 1998, the Provisional Technical Secretariat (PTS) of the Preparatory Commission for the CTBTO (Prep Com) held a regional Workshop for CTBTO International Cooperation in Cairo. The purpose of the workshop was to identify how and by what means the Africa region can promote international cooperation in CTBT verification related technologies, and how the region can benefit from and contribute to Prep Com activity. PTS staff briefed the 40 participants from 22 African States who attended the Workshop on general aspects, including costs, of the establishment and operation of the CTBT verification system, including its four monitoring technologies. Participants were informed on opportunities for local institutions in the establishment of monitoring stations and on possible support for national and regional data centres. National experts presented their research and development activities and reviewed existing experiences on bi/multi-lateral cooperation. The main points of the discussion focused on the need to engage governments to advance signature/ratification, and further training opportunities for African states

  5. IFPA meeting 2012 workshop report I

    DEFF Research Database (Denmark)

    Ackerman, W E; Carter, Anthony Michael; De Mestre, A M

    2013-01-01

    Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2012 there were twelve themed workshops, three of which are summarized in this report. These workshops related to various aspects of placental biology but collectively...

  6. IFPA Meeting 2013 Workshop Report II

    DEFF Research Database (Denmark)

    Ackerman, W E; Adamson, L; Carter, Anthony Michael

    2013-01-01

    Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At the IFPA meeting 2013 twelve themed workshops were presented, five of which are summarized in this report. These workshops related to various aspects of placental biology but collecti...

  7. Systems Engineering 2010 Workshop | Wind | NREL

    Science.gov (United States)

    0 Workshop Systems Engineering 2010 Workshop The 1st NREL Wind Energy Systems Engineering Workshop of the system engineering model. In the middle of the model is optimization, metric tracking &M model, capital cost model, and balance of station. Systems engineering represents a holistic

  8. IFPA meeting 2010 workshop report I

    DEFF Research Database (Denmark)

    Abad, C.; Antczak, D.F.; Carvalho, J.

    2011-01-01

    Workshops are an important part of the IFPA annual meeting. At IFPA Meeting 2010 there were twelve themed workshops, six of which are summarized in this report. 1. The immunology workshop focused on normal and pathological functions of the maternal immune system in pregnancy. 2. The transport wor...

  9. Many body theory program

    International Nuclear Information System (INIS)

    Balatsky, A.V.; Scalapino, D.; Wilkins, J.; Pines, D.; Bedell, K.; Schrieffer, J.R.; Fisk, Z.

    1998-01-01

    This is the final report of a two-year, Laboratory-Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The authors have obtained a description of symmetry of the order parameter and pairing state in high-Tc superconductors. They developed a theory of ferromagnetic instability of Fermi-liquid. They have conducted an experimental investigation of the intermetallic compounds and Zintl-type compound. They investigated the properties of Cu-0 ladders. They have developed the theory of liftshitz tails in superconductors. They have conducted a number of summer workshops

  10. Integrable System and $N=2$ Supersymmetric Yang-Mills Theory

    OpenAIRE

    Nakatsu, T.; Takasaki, K.

    1996-01-01

    Comment: 6 pages,latex file with sprocl.sty, no figures, to appear in the Proceedings of the Workshop (Talk presented at the Workshop "Frontiers in Quantum Field Theory" in honor of the 60th birthday of Prof. Keiji Kikkawa, Osaka, Japan, December 1995

  11. Spent fuel workshop'2002

    International Nuclear Information System (INIS)

    Poinssot, Ch.

    2002-01-01

    This document gathers the transparencies of the presentations given at the 2002 spent fuel workshop: Session 1 - Research Projects: Overview on the IN CAN PROCESSES European project (M. Cowper), Overview on the SPENT FUEL STABILITY European project (C. Poinssot), Overview on the French R and D project on spent fuel long term evolution, PRECCI (C. Poinssot); Session 2 - Spent Fuel Oxidation: Oxidation of uranium dioxide single crystals (F. Garrido), Experimental results on SF oxidation and new modeling approach (L. Desgranges), LWR spent fuel oxidation - effects of burn-up and humidity (B. Hanson), An approach to modeling CANDU fuel oxidation under dry storage conditions (P. Taylor); Session 3 - Spent Fuel Dissolution Experiments: Overview on high burnup spent fuel dissolution studies at FZK/INE (A. Loida), Results on the influence of hydrogen on spent fuel leaching (K. Spahiu), Leaching of spent UO 2 fuel under inert and reducing conditions (Y. Albinsson), Fuel corrosion investigation by electrochemical techniques (D. Wegen), A reanalysis of LWR spent fuel flow through dissolution tests (B. Hanson), U-bearing secondary phases formed during fuel corrosion (R. Finch), The near-field chemical conditions and spent fuel leaching (D. Cui), The release of radionuclides from spent fuel in bentonite block (S.S. Kim), Trace actinide behavior in altered spent fuel (E. Buck, B. Hanson); Session 4 - Radiolysis Issues: The effect of radiolysis on UO 2 dissolution determined from electrochemical experiments with 238 Pu doped UO 2 M. Stroess-Gascoyne (F. King, J.S. Betteridge, F. Garisto), doped UO 2 studies (V. Rondinella), Preliminary results of static and dynamic dissolution tests with α doped UO 2 in Boom clay conditions (K. Lemmens), Studies of the behavior of UO 2 / water interfaces under He 2+ beam (C. Corbel), Alpha and gamma radiolysis effects on UO 2 alteration in water (C. Jegou), Behavior of Pu-doped pellets in brines (M. Kelm), On the potential catalytic behavior of

  12. Welcome from the Workshop Chairs

    NARCIS (Netherlands)

    Berntsson Svensson, Richard; Daneva, Maia; Marczak, Sabrina; Ernst, Neil; Madhavji, N.

    2015-01-01

    Welcome to the fifth International Workshop on Empirical Requirements Engineering (EmpiRE 2015) at RE’15! In the past few years, some important developments in the Information Technology Services marketplace as well as in the software industry in particular fueled the debate on the evaluation of

  13. WORKSHOP: Electron-positron mystery

    International Nuclear Information System (INIS)

    Bokemeyer, H.; Mueller, B.

    1989-01-01

    The tightly correlated electron-positron pairs seen in experiments at the GSI Darmstadt heavy ion Laboratory and elsewhere have yet to be explained. New particle or new effect? The question was highlighted at a recent Moriond workshop held at Les Arcs in the French Alps in January

  14. VBSCan Split 2017 Workshop Summary

    Energy Technology Data Exchange (ETDEWEB)

    Anders, Christoph Falk; et al.

    2018-01-12

    This document summarises the talks and discussions happened during the VBSCan Split17 workshop, the first general meeting of the VBSCan COST Action network. This collaboration is aiming at a consistent and coordinated study of vector-boson scattering from the phenomenological and experimental point of view, for the best exploitation of the data that will be delivered by existing and future particle colliders.

  15. 2017 NREL Photovoltaic Reliability Workshop

    Energy Technology Data Exchange (ETDEWEB)

    Kurtz, Sarah [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-08-15

    NREL's Photovoltaic (PV) Reliability Workshop (PVRW) brings together PV reliability experts to share information, leading to the improvement of PV module reliability. Such improvement reduces the cost of solar electricity and promotes investor confidence in the technology -- both critical goals for moving PV technologies deeper into the electricity marketplace.

  16. Workshops on radiation imaging detectors

    Energy Technology Data Exchange (ETDEWEB)

    Sochinskii, N V; Sun, G C; Kostamo, P; Silenas, A; Saynatjoki, A; Grant, J; Owens, A; Kozorezov, A G; Noschis, E; Van Eijk, C; Nagarkar, V; Sekiya, H; Pribat, D; Campbell, M; Lundgren, J; Arques, M; Gabrielli, A; Padmore, H; Maiorino, M; Volpert, M; Lebrun, F; Van der Putten, S; Pickford, A; Barnsley, R; Anton, M E.G.; Mitschke, M; Gros d' Aillon, E; Frojdh, C; Norlin, B; Marchal, J; Quattrocchi, M; Stohr, U; Bethke, K; Bronnimann, C H; Pouvesle, J M; Hoheisel, M; Clemens, J C; Gallin-Martel, M L; Bergamaschi, A; Redondo-Fernandez, I; Gal, O; Kwiatowski, K; Montesi, M C; Smith, K

    2005-07-01

    This document gathers the transparencies that were presented at the international workshop on radiation imaging detectors. 9 sessions were organized: 1) materials for detectors and detector structure, 2) front end electronics, 3) interconnected technologies, 4) space, fusion applications, 5) the physics of detection, 6) industrial applications, 7) synchrotron radiation, 8) X-ray sources, and 9) medical and other applications.

  17. Workshops on radiation imaging detectors

    International Nuclear Information System (INIS)

    Sochinskii, N.V.; Sun, G.C.; Kostamo, P.; Silenas, A.; Saynatjoki, A.; Grant, J.; Owens, A.; Kozorezov, A.G.; Noschis, E.; Van Eijk, C.; Nagarkar, V.; Sekiya, H.; Pribat, D.; Campbell, M.; Lundgren, J.; Arques, M.; Gabrielli, A.; Padmore, H.; Maiorino, M.; Volpert, M.; Lebrun, F.; Van der Putten, S.; Pickford, A.; Barnsley, R.; Anton, M.E.G.; Mitschke, M.; Gros d'Aillon, E.; Frojdh, C.; Norlin, B.; Marchal, J.; Quattrocchi, M.; Stohr, U.; Bethke, K.; Bronnimann, C.H.; Pouvesle, J.M.; Hoheisel, M.; Clemens, J.C.; Gallin-Martel, M.L.; Bergamaschi, A.; Redondo-Fernandez, I.; Gal, O.; Kwiatowski, K.; Montesi, M.C.; Smith, K.

    2005-01-01

    This document gathers the transparencies that were presented at the international workshop on radiation imaging detectors. 9 sessions were organized: 1) materials for detectors and detector structure, 2) front end electronics, 3) interconnected technologies, 4) space, fusion applications, 5) the physics of detection, 6) industrial applications, 7) synchrotron radiation, 8) X-ray sources, and 9) medical and other applications

  18. Physics Analysis Tools Workshop 2007

    CERN Multimedia

    Elizabeth Gallas,

    The ATLAS PAT (Physics Analysis Tools) group evaluates, develops and tests software tools for the analysis of physics data, consistent with the ATLAS analysis and event data models. Following on from earlier PAT workshops in London (2004), Tucson (2005) and Tokyo (2006), this year's workshop was hosted by the University of Bergen in Norway on April 23-28 with more than 60 participants. The workshop brought together PAT developers and users to discuss the available tools with an emphasis on preparing for data taking. At the start of the week, workshop participants, laptops and power converters in-hand, jumped headfirst into tutorials, learning how to become trigger-aware and how to use grid computing resources via the distributed analysis tools Panda and Ganga. The well organised tutorials were well attended and soon the network was humming, providing rapid results to the users and ample feedback to the developers. A mid-week break was provided by a relaxing and enjoyable cruise through the majestic Norwegia...

  19. Django Girls 2017 Workshop Saturday

    CERN Multimedia

    Lapka, Marzena

    2017-01-01

    On 7th and 8th April 2017 CERN welcomed its second Django Girls Geneva event at IdeaSquare. The workshop was organised by the CERN IT Department, Diversity and Local Engagement teams. Many volunteered helped to make it happen.

  20. IAEA monitoring field trials workshop

    International Nuclear Information System (INIS)

    Ross, H.H.; Cooley, J.N.; Belew, W.L.

    1995-01-01

    Recent safeguards inspections in Iraq and elsewhere by the International Atomic Energy Agency (IAEA) have led to the supposition that environmental monitoring can aid in verifying declared and in detecting undeclared nuclear activities or operations. This assumption was most recently examined by the IAEA's Standing Advisory Group on Safeguards Implementation (SAGSI), in their reports to the IAEA Board of Governors. In their reports, SAGSI suggested that further assessment and development of environmental monitoring would be needed to fully evaluate its potential application to enhanced IAEA safeguards. Such an inquiry became part of the IAEA ''Programme 93+2'' assessment of measures to enhance IAEA safeguards. In March, 1994, the International Safeguards Group at Oak Ridge hosted an environmental monitoring field trial workshop for IAEA inspectors to train them in the techniques needed for effective environmental sampling. The workshop included both classroom lectures and actual field sampling exercises. The workshop was designed to emphasize the analytical infrastructure needed for an environmental program, practical sampling methods, and suggested procedures for properly planning a sampling campaign. Detailed techniques for swipe, vegetation, soil, biota, and water associated sampling were covered. The overall approach to the workshop, and observed results, are described