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Sample records for pityriasis

  1. Pityriasis amiantacea.

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    Moon, C M; Schissel, D J

    1999-03-01

    Pityriasis amiantacea is an easily recognizable cutaneous disease that is characterized by scaling of the scalp and temporary alopecia. The scaling, described as thick and asbestos-like, binds down tufts of hair. The alopecia may be temporary or scarring. Despite a well-established clinical description, no definitive etiology has been uncovered. This disease may represent seborrheic dermatitis, superficial fungal or pyogenic infections, lichen planus, or psoriasis. Histologically, the disease is characterized by eczematous features. We report a case of pityriasis amiantacea in an 11-year-old girl with simultaneous findings of psoriasis as well as review the literature on the etiology of this disease.

  2. Case report. Pityriasis versicolor mimicking Pityriasis rotunda.

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    Aste, Nicola; Pau, Monica; Aste, Natalia; Biggio, P

    2002-04-01

    Pityriasis versicolor is a common dermatomycosis, occurring throughout the world, characterized by irregular, slightly scaly patches, varying in color from red/light brown to white. Pityriasis rotunda, on the other hand, is an uncommon disease, reported in specific ethnic groups, and characterized by perfectly round or oval patches of varying color, with a scaly surface. The histologic pattern is that of ichthyosis vulgaris. We report here the case of a male patient, aged 31, from Sardinia (Italy), affected by Pityriasis versicolor mimicking Pityriasis rotunda. Mycological examination allowed us to formulate the correct diagnosis, and ensuing treatment with antifungal drugs was entirely successful. The authors, while pointing out the rarity of this case, stress the possibility that Pityriasis versicolor mimics Pityriasis rotunda and vice-versa, especially in those countries in which the two diseases are endemic. More widespread recourse to microscopic examination can help avoid the risk of mistaken diagnosis and consequent incorrect treatment.

  3. [Pityriasis rubra pilaris].

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    Wollina, U

    2012-08-01

    Pityriasis rubra pilaris is an inflammatory papulosquamous skin disease of unknown etiology. Incidence rates vary between 1:5,000-1:50,000. Six subtypes are differentiated on clinical background. The juvenile circumscribed subtype has best prognosis. Generalized disease impairs quality of life of patients. It is associated with various complications and comorbidities. Treatment of pityriasis rubra pilaris is challenging. Retinoids are first line drugs. In recalcitrant cases, tumor necrosis factor-α inhibitors have been used successfully.

  4. Pityriasis versicolor alba.

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    Thoma, W; Krämer, H-J; Mayser, P

    2005-03-01

    Pityriasis versicolor alba is a hypopigmented or depigmented variant of pityriasis versicolor characterized by maculous, partly pityriasiform, scaly depigmented lesions occurring particularly in seborrhoeic areas. Long-persisting hypopigmentation after healing of the pityriasis versicolor was first described by Gudden in 1853. Hypopigmentation and depigmentation were later differentiated as an independent variant of the disease. In 1848, Eichstedt recognized the pathogen-related character of pityriasis versicolor in its hyperpigmented form. Today it is generally accepted that the disease is caused by yeasts of the genus Malassezia, of which nine species are differentiated. It is controversial whether a single species is responsible for the disease. The pathogenesis of depigmentation has not been established. A screening effect by the scale layer as well as toxic effects on pigment synthesis by fungal metabolites have been discussed. With regard to the second mechanism, the newly discovered tryptophan-derived metabolites of M. furfur might be significant. Evidence-based data concerning the therapy of pityriasis versicolor alba do not exist. According to current recommendations, pityriasis versicolor should be rapidly treated with antimycotics, followed by ultraviolet therapy to induce maturation of existent melanosomes and accelerate repigmentation. However, depigmented lesions are difficult to improve by ultraviolet therapy.

  5. Pityriasis alba with poliosis.

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    Malik, Tayyaba Gul; Khalil, Muhammad; Bhatti, Muhammad Moeen

    2014-02-01

    Pityriasis alba is a skin disease, commonly seen in children and young adults. This case presents the ocular association of this disease in a 10 years old Pakistani male. Ocular features in this case were poliosis, tilted disc, high myopia and chorioretinal degeneration. Tilted discs and high myopia can be coincidental but poliosis and decreased pigment in retinal pigment epithelium are closely related with the hypopigmentation seen in this disease.

  6. Pityriasis lichenoides and lymphomatoid papulosis.

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    Rogers, M

    1992-03-01

    The clinical features, histopathology, immunopathology, and management of pityriasis lichenoides and lymphomatoid papulosis are discussed, with particular emphasis on the pediatric aspects of these conditions. The difficulties in logically separating pityriasis lichenoides into an acute (pityriasis lichenoides et varioliformis acuta) and a chronic (pityriasis lichenoides chronical) form are addressed. The development of lymphoreticular malignancy in patients with lymphomatoid papulosis has been well documented, but pityriasis lichenoides has characteristically been regarded as a benign condition. However, recent reports of the development of large plaque parapsoriasis in patients with pityriasis lichenoides have led to a reconsideration. Some of these patients were in the pediatric age group. Although there are significant clinical, histopathological, and immunopathological differences between pityriasis lichenoides and lymphomatoid papulosis, the demonstration of similar clonal T cell receptor gene rearrangements and the confirmation of the potentially premalignant nature of both suggests that there may indeed be an interrelationship between these two controversial entities. Close follow-up of patients with both of these conditions is recommended, with observation being discontinued only when the patient has been free of lesions for several years.

  7. Uncommon cases of pityriasis versicolor.

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    Romano, C

    2008-06-01

    Malassezia may play a role in several dermatoses. It is responsible for foliculitis and mainly for pityriasis versicolor. Pityriasis versicolor is the most known dermatitis because of its clinical aspects and frequently for its poor response to the therapy, mainly in chronic forms. The clinical aspects of uncommon and rare forms of pityriasis versicolor have been reported. The data related to the patients observed in the last thirty years in Siena are reported. In addition, a study was carried out in Pisa by Professor F. Mancianti to identify species of Malassezia isolated in 37 patients.

  8. Vesicular palmoplantar pityriasis rosea.

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    Singh, Varinder; Sharma, Meghna; Narang, Tarun; Madan, Manas

    2012-01-01

    A 16-year-old young man presented with intensely itchy erythematous dermatitis on the body for 1 week and vesicular lesions on the palms and soles for 4 to 5 days. Lesions on the palms and soles were accompanied by severe burning and itching. The patient gave a history of sore throat and fever, 1 week prior to the onset of lesions. A general physical examination was normal, and cutaneous examination revealed multiple, well-defined erythematous scaly plaques with collaret scaling on the trunk and extremities (Figure 1). Vesicular lesions were seen on the palms and soles (Figure 2). The differential diagnoses we considered were pityriasis rosea and secondary syphilis. The possibility of dermatophytid, vesicular pityriasis rosea, and pompholyx was limited to the palms and sole lesions. Complete blood cell count was within normal limits. Results from antistreptolysin O titer, potassium hydroxide mount, and venereal disease research laboratory were negative. Skin biopsies were taken from the back and left palm. The biopsy specimen from the back revealed focal spongiosis, lymphocyte exocytosis, vacuolar changes in the basal layer, and perivascular lymphocytic infiltrate in the dermis (Figure 3). The biopsy obtained from the vesicular lesion on the left palm revealed an intraepidermal vesicle with no evidence of acantolytic process (Figure 4). A diagnosis of pityriasis rosea was made and the patient was started on clarithromycin 500 mg once a day for 7 days, along with antihistamines and emollients. The lesions faded dramatically in a very short period, and there was significant involution of almost all of the lesions after 7 days of clarithromycin. During the 6 months of follow-up, no recurrence was observed.

  9. Does pityriasis rosea Koebnerise?

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    Nwabudike Lawrence Chukwudi

    2013-04-01

    Full Text Available The Koebner phenomenon or isomorphic phenomenon is described in dermatology texts as the production of lesions of the original disease, in clinically uninvolved skin, following trauma. The lesions are located at the site of trauma and evidence of a traumatic causation is the linear arrangement of some of the lesions, such as in the case of lichen planus. Other disorders known to exhibit the Koebner phenomenon include psoriasis and vitiligo. A number of other diseases are associated with the Koebner phenomenon. Pathergy is a phenomenon of pustule production following trauma, which occurs in certain disorders such as Pyoderma gangrenosum and Behçet?s disease. In some disorders such as impetigo and verruca vulgaris, inoculation may give the appearance of the Koebner phenomenon. A case of pityriasis rosea and Koebner phenomenon at the site of routine blood assay is described in this work. This author has not thus far encountered any description of the Koebner reaction in relation to pityriasis rosea in the literature, but, perhaps, with this report, other physicians will be more open to this possibility and actually uncover similar cases.

  10. Blaschkoid pityriasis versicolor.

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    Tan, Cheng; Zhu, Wen-Yuan; Min, Zhong-Sheng

    2010-07-01

    A 31-year-old male patient complained of having follicular and brownish red maculopapules along the Blaschko's lines on the right chest for 2 days. On examination, follicular brownish maculopapules were present on the chest with a uniform size of about 3 mm in diameter. The lesions were isolated without a tendency to merge, giving several S-shaped, band-like appearances. Direct mycological examination of the skin flakes revealed many pseudomycelial hyphae and yeast cells with typical spaghetti and meatball appearance. Wood's light examination of the lesion revealed a golden yellow fluorescence. A diagnosis of blaschkoid pityriasis versicolor was suggested because of blaschkoid distribution of the lesions in this new variant of PV.

  11. Relapsing pityriasis rosea.

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    Drago, Francesco; Ciccarese, Giulia; Rebora, Alfredo; Parodi, Aurora

    2014-01-01

    To assess the prevalence of relapses of pityriasis rosea (PR), a retrospective cohort study investigated all PR cases diagnosed in Genoa between 2000 and 2013 and followed them up to today. Of 570 cases, 21 (3.7%) relapsed. Most of them had a single episode, but 4 had two episodes and 2 had three episodes. The herald patch was always absent, size and number of the lesions were reduced, and duration was shorter than that of the primary episodes. Constitutional symptoms were present, though less severe than in the primary eruption. Most recurrences occurred within 1 year (16/21, 76.2%). Men outnumbered women and the mean age of the relapsing patients (20.3 years) was higher than that for the primary episode. A pathogenetic hypothesis is provided: since PR is associated with reactivation of human herpesvirus 6/7, a parallelism with other typical reactivating human herpesviruses (varicella zoster virus and Epstein-Barr virus) has been established.

  12. Pityriasis rosea - An update

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    Chuh Antonio

    2005-01-01

    Full Text Available Recent controversies on the etiology, diagnosis and treatment have led to increased interest in pityriasis rosea (PR. We review these aspects of the disease. PR is universal. The incidence is around 0.68 per 100 dermatological patients, or 172.2 per 100,000 person-years. The prevalence in people aged between 10 and 29 years is 0.6%. The male to female ratio is around 1: 1.43. Evidence on seasonal variation is conflicting, but there is no evidence that the incidence is dependent on mean air temperature, mean total rainfall, or mean relative humidity. Spatial-temporal and temporal clustering of cases of PR has been reported. The association of PR with human herpesvirus-7 infection is still controversial. Owing to the extreme high sensitivities of sequence-based detection methods such as polymerase chain reaction, novel criteria should be applied to evaluate the evidence. There is no evidence that PR is associated with other viral or bacterial infections. The role of autoimmunity in PR warrants further investigations. Many patients with PR have one or more atypical features. Application of validated diagnostic criteria may be helpful for atypical cases. The efficacy of macrolides, including erythromycin, in PR is still under evaluation. There is no evidence that antiviral agents are effective. The efficacies of ultraviolet radiotherapy and systemic corticosteroids are not well established. In managing a patient with PR, we should concentrate more on how the eruption is affecting the quality of life, i.e. the illness, rather than the extent and severity of the eruption, i.e. the disease.

  13. Adult onset pityriasis rubra pilaris

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    Sehgal Virendra

    2008-01-01

    Full Text Available Pityriasis rubra pilaris (PRP has always been an intriguing topic ever since its inception. It is a group of chronic disorders characterized by reddish orange plaques with pityriasiform scaling showing follicular keratoses, palmoplantar keratoderma, and sometimes, erythroderma. It occurs all over the world but with racial variations. Its incidence might vary and the age at onset, behavior, clinical appearance, and prognosis are considered to be very important for its classification. It may manifest either as Type I classical adult onset PRP, Type II atypical adult (onset PRP, or Type VI PRP (HIV-associated PRP pityriasis rubra pilaris in contrast to classical juvenile (Type III and circumscribed juvenile (Type IV encountered among children. Its diagnosis is largely clinical with microscopic pathology being a useful supplement, but it continues to be a therapeutic dilemma. We review the epidemiology of adult onset PRP here and take stock of the prevalent treatment options.

  14. Pityriasis amiantacea: a case report.

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    Ayanlowo, O O; Olowoyo, O O; Akinkugbe, A O; Adelekan, F A; Ahamneze, N C

    2014-06-01

    Pityriasis amiantacea (PA) is a papulosquamous condition of the scalp,characterized by asbestos - like thick scales attached to the hair shaft. It is thought to represent a reaction pattern to inflammatory skin disorders like psoriasis, seborrhoeic dermatitis, tinea capitis, atopic dermatitis and lichen planus, rather than a distinctive disease. The scaling may be localised or generalised, depending on the underlying condition and its duration.This report highlights the clinical features of pityriasis amiantacea secondary to atopic dermatitis and the differential features of other papulo-squamous scalp disorders such as scalp psoriasis, seborrhoeic dermatitis and lichen planus.Scalp psoriasis and seborrhoeic dermatitis are the commonest causes of PA as well as the closest differentials hence should be excluded in all cases. The longterm sequelae of PA include scalp fibrosis and permanent hair loss hence should be identified and treated promptly. The management modalities of PA will also be discussed.

  15. Pityriasis rosea: A histopathologic study

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    Prasad D

    2000-01-01

    Full Text Available The histopathologic features of pityriasis rosea (PR have been considered by many authors to be compatible with those of dermatitis, but it is not surprising that histological difference may exist between PR and dermatitis. fifty patients of pityriasis rosea were included in this study. We studied the 50 biopsies including 9 biopsies from herald patches. The characteristic features were; absence or decrease of the granular cell layer, extravasation of red blood cells in papillary dermis and partly into the epidermis, dyskeratosis, liquefaction of basal cells, homogenization of papillary collagen, intraepidermal vesicles in apparently dry skin. In addition of these features, we observed prominent delling of epidermis and a typical spongiotic pattern not reported earlier. The biopsies from herald patches showed minor differences from the secondary lesions. We also compared the histopathological features of recent lesions with older lesions.

  16. Pityriasis amiantacea: a study of seven cases*

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    Amorim, Gustavo Moreira; Fernandes, Nurimar Conceição

    2016-01-01

    Pityriasis amiantacea was first described in 1832. The disease may be secondary to any skin condition that primarily affects the scalp, including seborrheic dermatitis. Its pathogenesis remains uncertain. We aim to analyze the epidemiological and clinical profiles of patients with pityriasis amiantacea to better understand treatment responses. We identified seven cases of pityriasis amiantacea and a female predominance in a sample of 63 pediatric patients with seborrheic dermatitis followed for an average of 20.4 months. We reported a mean age of 5.9 years. Five patients were female, with a mean age of 9 years. All patients were successfully treated with topic ketoconazole. PMID:27828657

  17. Pityriasis amiantacea: a study of seven cases.

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    Amorim, Gustavo Moreira; Fernandes, Nurimar Conceição

    2016-01-01

    Pityriasis amiantacea was first described in 1832. The disease may be secondary to any skin condition that primarily affects the scalp, including seborrheic dermatitis. Its pathogenesis remains uncertain. We aim to analyze the epidemiological and clinical profiles of patients with pityriasis amiantacea to better understand treatment responses. We identified seven cases of pityriasis amiantacea and a female predominance in a sample of 63 pediatric patients with seborrheic dermatitis followed for an average of 20.4 months. We reported a mean age of 5.9 years. Five patients were female, with a mean age of 9 years. All patients were successfully treated with topic ketoconazole.

  18. Palmar herald patch in pityriasis rosea.

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    Polat, Mualla; Yildirim, Yasemin; Makara, Anil

    2012-08-01

    Pityriasis rosea is an acute self-limited inflammatory disorder of the skin. The initial clinical features of typical cases are the appearance of a herald patch. The herald patch is commonly located on the thigh, upper arm, trunk or neck; rarely the patch may be on the face, scalp or penis. There are no reports of a palmar herald patch in pityriasis rosea. In this article we present a 14-year-old male patient who had a palmar herald patch with truncal lesions of pityriasis rosea. © 2012 The Authors. Australasian Journal of Dermatology © 2012 The Australasian College of Dermatologists.

  19. Association pityriasis rubra pilaire et myasthenie

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    Fatima Zahra Agharbi

    2011-09-01

    Full Text Available Le pityriasis rubra pilaire est un trouble de keratinisation rare dont l�etiopathogenie reste inconnue mais dont l�association avec autres pathologies a ete deja rapportee. Nous rapportons l�observation d�une jeune patiente qui presente un pityriasis rubra pilaire associe a une myasthenie. Traitee par Neostigmine et thymectomie avec bonne evolution sur le plan neurologique. Vu son desir de grossesse un traitement systemique de son pityriasis rubra pilaire n�a pas pu etre instaure et l�evolution sous dermocorticoides n�etait pas tres favorable.

  20. Pityriasis rubra pilaris following exposure to dolomite.

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    Iraji, Fariba; Siadat, Amir H

    2013-07-01

    In this case report, we present a 30-year-old man who developed pityriasis rubra pilaris (PRP) following exposure to Dolomite. The diagnosis of PRP was confirmed histologically and the patient was successfully treated with acitretin and cyclosporine.

  1. Bilateral areolar and periareolar pityriasis versicolor.

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    Sárdy, Miklós; Korting, Hans Christian; Ruzicka, Thomas; Wolff, Hans

    2010-08-01

    An adolescent boy presented with isolated, symmetrical, bilateral areolar and periareolar pityriasis versicolor. This extremely rare condition should be considered in the differential diagnosis of light brown patches on the areolae.

  2. Pityriasis Amiantacea-Like Eruptions in Scalp: A Novel Manifestation of Pityriasis Rosea in a Child

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    Zawar, Vijay

    2010-01-01

    Unusual clinical features are known in pityriasis rosea (PR). We report a case of a child who presented with onset of PR in scalp, clinically mimicking pityriasis amiantacea. Careful clinical observations and follow-up led us to appropriate diagnosis. PMID:21712901

  3. Management of seborrheic dermatitis and pityriasis versicolor.

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    Faergemann, J

    2000-01-01

    Pityriasis (tinea) versicolor and seborrheic dermatitis are two very common skin diseases. Pityriasis versicolor is a chronic superficial fungal disease usually located on the upper trunk, neck, or upper arms. In pityriasis versicolor, the lipophilic yeast Malassezia (also know as Pityrosporum ovale or P. orbiculare) changes from the blastospore form to the mycelial form under the influence of predisposing factors. The most important exogenous factors are high temperatures and a high relative humidity which probably explain why pityriasis versicolor is more common in the tropics. The most important endogenous factors are greasy skin, hyperhidrosis, hereditary factors, corticosteroid treatment and immunodeficiency. There are many ways of treating pityriasis versicolor topically. Options include propylene glycol, ketoconazole shampoo, zinc pyrithione shampoo, ciclopiroxamine, selenium sulfide, and topical antifungals. In difficult cases, short term treatment with fluconazole or itraconazole is effective and well tolerated. To avoid recurrence a prophylactic treatment regimen is mandatory. Seborrheic dermatitis is characterized by red scaly lesions predominantly located on the scalp, face and upper trunk. There are now many studies indicating that Malassezia plays an important role in this condition. Even a normal number of Malassezia will start an inflammatory reaction. Mild corticosteroids are effective in the treatment of seborrheic dermatitis. However, the disease recurs quickly, often within just a few days. Antifungal therapy is effective in the treatment of seborrheic dermatitis and, because it reduces the number of Malassezia, the time to recurrence is increased compared with treatment with corticosteroids. Antifungal therapy should be the primary treatment of this disease.

  4. Vulvar pityriasis versicolor in an immunocompetent woman.

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    Day, Tania; Scurry, James

    2014-07-01

    To report a case of isolated vulvar pityriasis versicolor in a 24-year-old healthy woman. A 24-year-old woman presented with variable color change on the vulva of 8 months in duration. Areas of tan and white skin were observed on the mons pubis. The pubic hair had been shaved. Initially, the paler areas were deemed abnormal suggesting vitiligo, but the biopsy showed normal skin including normal numbers of melanocytes. Subsequently, biopsy of the tan area showed pityriasis versicolor. She was successfully treated with topical 2% ketoconazole, with gradual fading of lesions. With increased body awareness and the current popularity of pubic hair removal, young women may consult clinicians about color changes on the vulva. Clinicians should be aware that vulvar pityriasis versicolor may occur in healthy women with no other skin involvement.

  5. Malassezia Species and Pityriasis Versicolor

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    Gulin Rodoplu

    2016-01-01

    Full Text Available Malassezia species are found in part of the normal human cutaneous commensal flora, however it has been known for many years that the Malassezia yeasts are associated with a number of different human diseases ranging from pityriasis versicolor to seborrhoeic dermatitis. In addition, since the 1980s, they have been reported as causing opportunistic systemic infections. The taxonomy of Malassezia spp. has recently been modified to include 13 obligatorily lipophilic species, plus one non-obligatorily lipophilic species, which only rarely colonizes human hosts and currently the genus consist 14 species as M. furfur, M. pachydermatis, M. sympodialis, M. globosa, M. obtusa, M. slooffiae, M. restricta, M. dermatis, M. japonica, M. nana, M. yamatoensis, M. caprae, M. equina, M. cuniculi. Fastidious growth requirements of Malassezia yeasts defied the initial attempts to culture these organisms and their true identification and the relationship between different species only became apparent with the application of modern molecular techniques. The causative fungus is seen especially in such seborrheic areas as the scalp, face, trunk and upper back. Under the influence of various exogenous or endogenous predisposing factors, these yeasts change from the blastospore form to the mycelial form and become pathogenic. Diagnosis of pityriasis versicolor which is caused by Malassezia species is generally easy and lies on the basis of its clinical appearance and can be confirmed by mycological examination. The diagnosisis is mainly based on direct examination with potassium hydroxide (KOH and demonstration that represents pseudohyphae and blastoconidia as the typical %u201Cspaghetti and meatballs%u201D pattern. Characteristic features of the genus Malassezia include a distinctive morphology and an affinity for lipids in culture. Culture is necessary to recover the infecting strain, especially for epidemiologic purposes and also to test its antifungal susceptibility

  6. Fluconazole and itraconazole in pityriasis versicolor

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    Jaswal Ritu

    1999-01-01

    Full Text Available Pityriasis versicolor is a common superficial fungal infection caused by Malassezia species. It has a high incidence and prevalence in tropical climates. Although it responds well to treatment, relapses and recurrences are frequent. In the present study the therapeutic response of single dose fluconazole (400 mg with itraconazole (100mg twice daily ? 7 days was compared in sixty patients of pityriasis versicolor. No significant statistical difference (p>0.05% was observed between efficacy of two drugs. Therapy with fluconazole is preferable in view of single dose administration and lesser cost as compared to itraconazole.

  7. Pityriasis lichenoides with ulceronecrosis and hyperthermia: A rare variant of pityriasis lichenoides et varioliformis acuta

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    Virdi Sarvjit; Kanwar Amrinder; Saikia Uma

    2010-01-01

    Pityriasis lichenoides with ulceronecrosis and hyperthermia (PLUH) is a severe variant of pityriasis lichenoides et varioliformis acuta that is characterized by high fever and papulo-necrotic skin lesions. We report the case of a 49-year-old male with typical features of PLUH along with an unusual manifestation of extensive skin necrosis including involvement of the intertriginous regions. Systemic administration of corticosteroids and antibiotics did not help to control the disease and the p...

  8. Atypical pityriasis versicolor case report

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    Zonunsanga

    2015-04-01

    Full Text Available Pityriasis versicolor is a superficial fungal infection caused by mycelial form of Malassezia spp, which is confined to stratum corneum. It usually present in the trunk as either hypo or hyperpigmented, aymptomatic, round to oval macules of varying sizes, which may merged to form geographic shape. Diagnosis is usually done clinically, or KOH examination which shows typical spagetti and meat balls appearances, or even by wood’s lamp which shows orange to yellow fluorescence. The case series had been recording in between 2012 to 2013. Within that period, we had recorded 32 cases. All the patients which we had recorded presented with multiple, asymptomatic macules of small sizes varying from 1-2 cm in diameter to 3-4mm in diameter, usually round to oval, hypopigmented, non scaly lesions. 26 patients had lesions on forearms, 3 patients had lesions on dorsa of hands bilaterally, 3 patients had similar kind of lesions on thigh. Besnier’s test was positive in 14 (43.75% patients. KOH examinations showed fungal hyphae in 14 (33.33% patients with typical spagetti and meat balls appearances in 9 (8.13% patients. All of them were given and all of them got response and healed within 2-4 months.

  9. Oropharyngeal lesions in pityriasis rosea.

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    Ciccarese, Giulia; Broccolo, Francesco; Rebora, Alfredo; Parodi, Aurora; Drago, Francesco

    2017-07-17

    Pityriasis rosea (PR) is an exanthematous disease associated with the endogenous systemic reactivation of human herpesvirus-6 (HHV-6) and human herpesvirus-7 (HHV-7). Oropharyngeal lesions may be associated with the exanthema, but anecdotal evidence suggests that few dermatologists are aware of their occurrence. Classifying oropharyngeal lesions in PR, establishing their prevalence, and assessing their possible association with different PR forms. The records of all PR cases diagnosed in the Dermatology Clinic of Genoa University between 2003 and 2016 were retrospectively reviewed to examine sex and age of the patients, PR type, presence of enanthema, systemic symptoms, specific anti-HHV-6 and or HHV-7 serology, and HHV-6 and/or HHV-7 DNA loads. The oropharyngeal mucosa was carefully examined in 527 patients with PR. Painless oropharyngeal lesions were observed in 149 patients with PR (28%) and classified as erythematomacular, macular and papular, erythematovesicular, and petechial lesions. The petechial and macular and papular patterns were those most frequently observed. There was no statistically significant difference in the levels of HHV-6 and HHV-7 viremia in the plasma of patients with enanthema and those without. Because this was a retrospective study, biopsies on mucosal lesions were not performed. Our findings showed that enanthemas are frequently associated with forms of PR different from the classic form. Copyright © 2017 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

  10. Diagnosis and Treatment of Pityriasis Rubra Pilaris

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    Kubanov Alexey

    2014-12-01

    Full Text Available The article deals with clinical diagnosis and treatment of pityriasis rubra pilaris (PRP. The authors analyze the diagnostic errors, present literature review, and their own observations. The clinical study included 23 patients with pityriasis rubra pilaris: 18 women and 5 men, average age of 54 ± 7.2. The clinical diagnosis of all examined patients was subsequently confirmed by histological analysis of the skin. The primary clinical diagnosis was psoriasis in 15 (65.2% patients, 6 (26% patients received treatment for toxic exanthema, and only 2 (8.8% patients were presumptively diagnosed with pityriasis rubra pilaris. In conclusion, pityriasis rubra pilaris was initially misdiagnosed in 91.2% of patients. Considering the great number of diagnostic errors, we analyzed the main diagnostic and differential diagnostic features of PRP. The most effective of all synthetic retinoids in PRP treatment is acitretin. Although symptomatic improvement in PRP occurs within a month, substantial improvement, even clearing is possible within 4 - 6 months.

  11. Bevacizumab-induced pityriasis rubra pilaris-like eruption

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    Brown, Shannon; Fletcher, J. Wesley; Fiala, Katherine H.

    2016-01-01

    Pityriasis rubra pilaris is a rare inflammatory disorder characterized by follicular papules on an erythematous base often exhibiting islands of unaffected skin, follicular plugging, and palmoplantar hyperkeratosis. While vitamin A deficiency and autoimmune reactions have been hypothesized as possible etiologies of this condition, pityriasis rubra pilaris-like eruptions secondary to medications are extremely rare. To our knowledge, only three other cases have been reported, and pityriasis rub...

  12. Pityriasis rosea-like eruption induced by isotretinoin.

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    Gürel, Gülhan; Şahin, Sevinç; Çölgeçen, Emine

    2017-04-19

    Pityriasis rosea is a common, self-limited and inflammatory skin disease. The etiology is not clearly known. Viral agents, autoimmunity, psychogenic factors and drugs have all been suggested as risk factors. Isotretinoin is usually used in the treatment of resistant, nodulocytic acne. We present a case of pityriasis rosea-like eruption induced by isotretinoin. To our knowledge, this is the second clinical case of pityriasis rosea-like eruption induced by isotretinoin.

  13. Atrophying pityriasis versicolor: is this a new variant of pityriasis versicolor?

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    Yang, Yun-Seok; Shin, Min-Kyung; Haw, Choong-Rim

    2010-11-01

    An atypical clinical form of pityriasis versicolor has been infrequently reported, in which cutaneous atrophy is associated with individual pityriasis versicolor lesions. The pathogenesis of this atrophy remains unclear, but is believed to be a delayed-type hypersensitivity reaction to antigens derived from the Malassezia species. A 60-year-old man presented with multiple, slightly scaly, and depressed maculopatches or plaques on the trunk and extremities. Our microscopic examination of the skin scrapings on a KOH preparation revealed numerous short hyphae and spores. The patient was treated daily with 200 mg of itraconazole in combination with topical antifungals, achieving clinical improvement and mycological recovery, which was confirmed upon follow-up 1 month later. This is the first case report of atrophying pityriasis versicolor in Korea. It needs to be differentiated from other atrophying disorders of the skin.

  14. Hypopigmented macules: leprosy, atopy or pityriasis versicolor?

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    Massone, C; Cavalchini, A; Clapasson, A; Nunzi, E

    2010-12-01

    Lepromatous leprosy (LL) represents the highest infective and multibacillary form of leprosy. Clinical manifestations are consequent to the haematogenous spread of bacilli and include macules, plaques and nodules in a symmetric distribution or a diffuse infiltration of the skin. LL may mimic many different inflammatory and neoplastic skin diseases and in a small percentage of patients, skin manifestation may be atypical. This article reports the case of a South American child with LL presenting with symmetrically distributed hypopigmented macules previously misdiagnosed as pytiriasis alba, atopic dermatitis and pityriasis versicolor. Atopy and pityriasis versicolor are common skin conditions that can be also observed in leprosy patients and that can masquerade the diagnosis of LL, especially if occurring in dark skin. Dermatologists in Europe should be aware of this unusual form of presentation of leprosy and must take in mind Hansen disease in the differential diagnosis in patients coming from endemic areas.

  15. Pityriasis lichenoides chronica in association with Tubercular Lymphadenitis

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    Pandhi R

    1997-01-01

    Full Text Available A patient with pityriasis lichenoides chronica (PLC during the course of her skin disease developed tuberculosis of cervical lymph nodes. Anti-tuberculosis treatment resulted in remission of PLC. Mycobacterium tuberculosis could be one of the triggering agent in pityriasis lichenoides.

  16. Pityriasis lichenoides with ulceronecrosis and hyperthermia: A rare variant of pityriasis lichenoides et varioliformis acuta

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    Virdi Sarvjit

    2010-01-01

    Full Text Available Pityriasis lichenoides with ulceronecrosis and hyperthermia (PLUH is a severe variant of pityriasis lichenoides et varioliformis acuta that is characterized by high fever and papulo-necrotic skin lesions. We report the case of a 49-year-old male with typical features of PLUH along with an unusual manifestation of extensive skin necrosis including involvement of the intertriginous regions. Systemic administration of corticosteroids and antibiotics did not help to control the disease and the patient succumbed to death due to its fulminant nature.

  17. Pityriasis lichenoides with ulceronecrosis and hyperthermia: a rare variant of pityriasis lichenoides et varioliformis acuta.

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    Virdi, Sarvjit Kaur; Kanwar, Amrinder Jit; Saikia, Uma Nahar

    2010-01-01

    Pityriasis lichenoides with ulceronecrosis and hyperthermia (PLUH) is a severe variant of pityriasis lichenoides et varioliformis acuta that is characterized by high fever and papulo-necrotic skin lesions. We report the case of a 49-year-old male with typical features of PLUH along with an unusual manifestation of extensive skin necrosis including involvement of the intertriginous regions. Systemic administration of corticosteroids and antibiotics did not help to control the disease and the patient succumbed to death due to its fulminant nature.

  18. Pityriasis rubra pilaris (Devergie's disease: clinical case

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    Galkina ЕМ

    2016-09-01

    Full Text Available Pityriasis rubra pilaris (Devergie's disease is a rare chronic papulosquamous skin disease, it is of unknown etiology, leading to palmoplantar keratoderma, erythroderma and ectropion. Due to its rarity and difficulty in differentiating it with psoriasis, we are presenting our own observations and diagnostcis. We present a patient with a classical type 1 iasis rubra pilaris of a type I, whose condition improved significantly after treatment with systemic aromatic retinoids.

  19. Narrowband UVB in Treatment of Pityriasis Lichenoides

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    Evren Odyakmaz Demirsoy

    2012-12-01

    Full Text Available Objective: Pityriasis Likenoides (PL is an inflammatory skin disease with unknown cause. Currently, the disease is considered as one of the rare indications of narrowband ultraviolet (UV B and is treated in phototherapy units. However, literature about treatment results is still limited. The aim of this study was to investigate the effectiveness of narrowband UVB therapy for PL and also to compare these results with other study results. Methods: Patients who were diagnosed with pityriasis lichenoides chronica (PLK or pityriasis lichenoides et varioliformis acuta (PLEVA clinically and histopathologically and treated with narrowband UVB in our phototherapy unit through 2000 to 2011 were evaluated retrospectively. Results: Three of the patients were diagnosed with PLEVA, and also 14 of them as PLK through the group of 17 patients included in the study. Four patients (23.5% had complete response, 6 (35.3% had prominent response, 4 (23.5% had partial response and 3 (17.7% were unresponsive after a mean of 36.9 sessions. Eight patients could be reached, in this group 7 patients did not have a relapse in the 41.4 months period and only one patient had a relapse 24 weeks after treatment. Conclusion: It was assumed that narrowband UVB was a safe treatment method for PL.

  20. Pityriasis lichenoides in an Asian population.

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    Koh, Wei-Liang; Koh, Mark Jean-Aan; Tay, Yong-Kwang

    2013-12-01

    There are few studies comparing pityriasis lichenoides (PL) in adults and children, with fewer involving Asians. We compared the clinical profile and treatment outcomes of 10 adults and five children diagnosed with PL. We retrospectively reviewed a series of patients diagnosed with PL at our hospital from 2002 to 2008. We identified 10 adults and five children (nine adults and four children with pityriasis lichenoides chronica; one adult and one child with pityriasis lichenoides et varioliformis acuta). Mean age of onset of disease was 42.2 years in adults and 12.2 years in children. Median duration of disease before presentation was 5.5 months in adults and 6 months in children. Trunk and limbs were the most common sites of involvement. Itch was present in the majority. Almost all patients did not respond to topical corticosteroids. A good response was seen in three adults and two children treated with oral antibiotics. Three adults and two children responded to treatment with narrow-band ultraviolet B phototherapy. The median time to resolution was 8 months in adults and 21 months in children. Postinflammatory dyspigmentation was seen in six adults and four children. PL presents similarly in adults and children; however, it runs a longer course in children. In our series, postinflammatory hyperpigmentation was common, which may be explained by our patients' darker skin phototypes. We routinely prescribe oral antibiotics initially in patients without contraindications. Phototherapy may be useful in patients not responding to antibiotics. © 2013 The International Society of Dermatology.

  1. Surgical Management of Cicatricial Ectropion in Pityriasis Rubra Pilaris.

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    Haridas, Anjana S; Sullivan, Timothy J

    2016-01-01

    Pityriasis rubra pilaris is an idiopathic, papulosquamous dermatological disease. It is clinically and histologically distinct from, but may resemble, psoriasis. Pityriasis rubra pilaris can be self-limiting but may also run a protracted, relapsing course. Medical treatment may involve topical emollients, systemic retinoids, methotrexate, and/or tumor necrosis factor antagonists. Ocular complications include cicatricial ectropion. The authors describe the surgical management of 3 patients with cicatricial ectropion secondary to pityriasis rubra pilaris. All patients had procedures involving skin grafts; 1 patient required multiple operations. The management principles are discussed, including the role and timing of surgery, within the context of emerging treatments for pityriasis rubra pilaris. Patients with pityriasis rubra pilaris and cicatricial ectropion should be closely managed by both ophthalmologist and dermatologist. The eyelid position may improve with conservative or surgical measures. If surgery is required, the limitations of skin grafting under these circumstances should be anticipated and patients counseled appropriately.

  2. Prevalence of pityriasis versicolor in young Italian sailors.

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    Ingordo, V; Naldi, L; Colecchia, B; Licci, N

    2003-12-01

    Pityriasis versicolor is a superficial fungal disease with a world-wide distribution, but there are few available studies on its prevalence in the general population. To assess the prevalence of pityriasis versicolor in a representative sample of young Italian sailors, evaluating the influence of habits and risk factors in the affected individuals. Young cadets (n = 1024: 975 men and 49 women, mean age 22 years) of the Italian Navy Petty Officers' School in Taranto were consecutively examined by the same observer. The diagnosis of pityriasis versicolor was based on clinical picture and/or Wood's lamp examination. All the subjects filled in a questionnaire about sport practice, swimming pool attendance, marching, presence of hyperhidrosis and a positive clinical history of pityriasis versicolor in the past. The affected individuals were also asked if they were aware of their skin lesions. Differences between answers of affected and unaffected subjects were tested by Fisher's exact P-value test, and odds ratios were calculated. Pityriasis versicolor was diagnosed in 22 subjects (2.1%), all men, of whom 15 (68%) were not aware of their condition. No statistical association was found between active pityriasis versicolor and sport practice, swimming pool attendance, marching or presence of hyperhidrosis. A significant association [odds ratio 8.7 (95% confidence interval 3.3-21.5); Fisher's exact P-value test P history of pityriasis versicolor. The prevalence of pityriasis versicolor in this sample of young Italian sailors was not high, in agreement with the available surveys performed in the general population in temperate climates. Many affected subjects were not aware of their condition. The only important factor associated with pityriasis versicolor was a previous history of pityriasis versicolor. This observation could confirm the hypothesis that constitutional factors, e.g. seborrhoea and chemical constitution of sebum, may play a crucial role in temperate climates

  3. A clinical and histolopathological study of pityriasis lichenoides

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    Nair Pradeep

    2007-01-01

    Full Text Available Background: Pityriasis lichenoides is a papulosquamous disorder of unknown etiology with remissions and exacerbations. Histopathology helps greatly in the diagnosis of this condition. Aim: We studied clinical and histopathological features of pityriasis lichenoides in our patients. Methods: This is a 3-year retrospective and prospective, descriptive study of all patients clinically diagnosed as pityriasis lichenoides and confirmed by histopathology. All patients were studied clinically and histopathologically. Results: There were 51 (30 males and 21 females cases of pityriasis lichenoides in the study period. The maximum number of cases, 14 (27.45% were in their second decade of life. Pityriasis lichenoides chronica was diagnosed in 39 cases (76.47% and pityriasis lichenoides et varioliformis acuta (PLEVA in 12 cases (23.53%. Histopathologically, basal cell vacuolation and perivascular infiltrate were seen in all the cases. Exocytosis was seen in 45.1% of the cases. All the cases of PLEVA showed lymphocytic vasculitis albeit without fibrinoid deposition in the vessel walls. Conclusion: Pityriasis lichenoides is not a rare disorder. and is not a true lymphocytic vasculitis as blood vessel damage and fibrinoid deposition in the blood vessel walls were not seen in this study.

  4. Systemic sclerosis in a patient with pityriasis rubra pilaris.

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    Frikha, Faten; Frigui, Makram; Masmoudi, Hatem; Turki, Hamida; Bahloul, Zouhir

    2010-08-09

    Pityriasis rubra pilaris (PRP) is a rare, chronic erythematous squamous disorder of unknown etiology. It has been found in association with several autoimmune diseases, including thyroiditis, myositis, myasthenia gravis and vitiligo. Herein we report a case of systemic sclerosis in a patient with classic adult pityriasis rubra pilaris. A 38 year old woman with classic adult type 1 pityriasis rubra pilaris (PRP) developed progressive skin thickening of the trunk, face, upper and lower extremities after 2 years of PRP treatment with topical emollients and steroids. Clinical examination and immunological findings were consistent with SSc. Co-existence of these two rare conditions is documented for the first time.

  5. Systemic sclerosis in a patient with pityriasis rubra pilaris

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    Hamida Turki

    2010-08-01

    Full Text Available Pityriasis rubra pilaris (PRP is a rare, chronic erythematous squamous disorder of unknown etiology. It has been found in association with several autoimmune diseases, including thyroiditis, myositis, myasthenia gravis and vitiligo. Herein we report a case of systemic sclerosis in a patient with classic adult pityriasis rubra pilaris. A 38 year old woman with classic adult type 1 pityriasis rubra pilaris (PRP developed progressive skin thickening of the trunk, face, upper and lower extremities after 2 years of PRP treatment with topical emollients and steroids. Clinical examination and immunological findings were consistent with SSc. Co-existence of these two rare conditions is documented for the first time

  6. Pityriasis lichenoides chronica presenting with bilateral palmoplantar involvement.

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    Avshalumova, Lyubov; Richardson, Blakely; Miller, Richard

    2016-05-01

    Pityriasis lichenoides is an uncommon, acquired, idiopathic, self-limiting skin disease that poses a challenge to patients and clinicians to diagnose and treat. Several variants exist including pityriasis lichenoides et varioliformis acuta (PLEVA), pityriasis lichenoides chronica (PLC), and febrile ulcer-onecrotic Mucha-Habermann disease. Precise classification can be difficult due to an overlap of clinical and histologic features. In this case report we describe a patient with a rare presentation of PLC exhibiting bilateral palmoplantar involvement and mimicking psoriasis. We review the literature and discuss the clinical course, pathogenesis, and current treatment modalities of PLC.

  7. Juvenil Pityriasis Rubra Pilaris: A Case Report

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    M. Emin YANIK et al.

    2010-05-01

    Full Text Available Juvenile pityriasis rubra pilaris (PRP is an uncommon skin disease characterized by follicularkeratotic papules, erythemato-squamous plaques and palmoplantar keratoderma. Etyology isunknown. A 8 years-old boy presented with a 15 days history of scaly patches and plaques withfollicular papules involving his scalp and face. However he had palmoplantar keratoderma onhis hands and feet. Based upon clinical and histopatological findings, he was diagnosed asJuvenile PRP. Acitretin was initiated for therapy. We presented our case because of its rarity.

  8. Childhood Pityriasis Rosea Inversa without Herald Patch Mimicking Cutaneous Mastocytosis

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    Pelin Ertan

    2010-06-01

    Full Text Available Background:Pityriasis rosea is a self-limited inflammatory condition of the skin that mostly affects young adults. Several less common atypical presentations have been reported. Case Presentation:A 6-year old girl with red-brown maculopapular eruption sized 0, 5-1 cm in diameter localized on neck, trunk and popliteal region visited our general pediatric outpatient clinic. The eruption was wide spread especially on flexural areas. After consulting dermatologist skin biopsy was performed. According to clinical and histopathological findings as inverse (flexural pityriasis rosea was diagnosed. For treatment, systemic antihistamine, topical corticosteroid cream and emollient were applied. The lesions healed in two months. Spontaneous healing of the eruption also confirmed the diagnosis of pityriasis rosea. Conclusion:We present this interesting pediatric case to show and discuss pityriasis rosea, atypical presentations, differential diagnosis and the importance of dermatological examination and importance of dermatologic consultation for pediatric patients with skin eruption.

  9. Childhood Pityriasis rosea inversa without Herald Patch Mimicking Cutaneous Mastocytosis

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    Ermertcan, Aylin Türel; Özgüven, Aykan; Ertan, Pelin; Bilaç, Cemal; Temiz, Peyker

    2010-01-01

    Background Pityriasis rosea is a self-limited inflammatory condition of the skin that mostly affects young adults. Several less common atypical presentations have been reported. Case Presentation A 6-year old girl with red-brown maculopapular eruption sized 0, 5–1 cm in diameter localized on neck, trunk and popliteal region visited our general pediatric outpatient clinic. The eruption was wide spread especially on flexural areas. After consulting dermatologist skin biopsy was performed. According to clinical and histopathological findings as inverse (flexural) pityriasis rosea was diagnosed. For treatment, systemic antihistamine, topical corticosteroid cream and emollient were applied. The lesions healed in two months. Spontaneous healing of the eruption also confirmed the diagnosis of pityriasis rosea. Conclusion We present this interesting pediatric case to show and discuss pityriasis rosea, atypical presentations, differential diagnosis and the importance of dermatological examination and importance of dermatologic consultation for pediatric patients with skin eruption. PMID:23056712

  10. An Atypical Case of Pityriasis Rosea Gigantea after Influenza Vaccination

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    Dimitrios Papakostas

    2014-04-01

    Full Text Available Pityriasis rosea is a common erythematosquamous eruption, typically presenting along the cleavage lines of the skin. A wide spectrum of atypical manifestations may challenge even the most experienced physician. Here we report a rare case of a suberythrodermic pityriasis rosea with gigantic plaques after an influenza vaccination, and we discuss the possible triggers of atypical manifestations of such a common dermatological disease in the setting of an altered immunity.

  11. Study of role of streptococcal throat infection in pityriasis rosea

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    Parija Madhuri

    2008-01-01

    Full Text Available Background: Pityriasis rosea is a common, acute exanthem of uncertain etiology. The exact cause of pityriasis rosea is not known but various hypotheses have been postulated incriminating infective agents such as viruses, bacteria, spirochete and noninfective etiologies such as atopy and autoimmune causes have also been investigated. Aim: We undertook a study to investigate the role of Streptococcus haemolyticus in the causation of pityriasis rosea and study the levels of C-reactive protein (CRP and ASLO titer in patients with pityriasis rosea. Materials and Methods: The study included 20 patients with pityriasis rosea attending the outpatient dermatology department at JIPMER hospital during the period from June to December 2004. Corresponding number of age- and sex-matched controls were chosen from amongst healthy individuals and patients attending skin OPD with dermatological disorders other than pityriasis rosea. Results: On analyzing the data collected from 20 cases of pityriasis rosea, the average age was found to be 15.3 years and ranged from 5 years to 30 years. The male to female ratio was found to be 1.5:1. The average duration of illness was 14.5 days (median and 29.3 days (mean. CRP was negative in all the cases as well as the controls. ASLO titer was found to be raised in 2 (10% cases, while it remained below the critical value in all the controls. On comparing the cases and controls, the raised ASLO titer in the cases was found to be not statistically significant (p = 0.147. From the throat swab culture, Streptococcus haemolyticus was isolated from only one case and none of the controls. This finding was not statistically significant (p = 0.310. Conclusion: As per the findings of the present study, we arrived at conclusion that there is no association between streptococcus pharyngitis and pityriasis rosea.

  12. An Atypical Case of Pityriasis Rosea Gigantea after Influenza Vaccination

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    Dimitrios Papakostas; Stavropoulos, Panagiotis G; Dafni Papafragkaki; Ekaterini Grigoraki; Georgia Avgerinou; Christina Antoniou

    2014-01-01

    Pityriasis rosea is a common erythematosquamous eruption, typically presenting along the cleavage lines of the skin. A wide spectrum of atypical manifestations may challenge even the most experienced physician. Here we report a rare case of a suberythrodermic pityriasis rosea with gigantic plaques after an influenza vaccination, and we discuss the possible triggers of atypical manifestations of such a common dermatological disease in the setting of an altered immunity.

  13. Ketoconazole 2% shampoo in pityriasis versicolor: An open trial

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    Rathi S

    2003-03-01

    Full Text Available Pityriasis versicolor is a common superficial fungal infection caused by a lipophilic yeast. The aim of the study was to evaluate the efficacy of ketoconazole 2% shampoo in the treatment of pityriasis versicolor, for which thirty patients were included. The shampoo was applied daily for 3 days and found to be very effective in clearing the signs and symptoms of the disease. There was no serious adverse effects.

  14. A clinicoepidemiological study of pityriasis rosea in South India.

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    Ganguly, Satyaki

    2013-01-01

    Pityriasis rosea is an acute self-limiting papulosquamous skin disorder of unknown etiology. Although pityriasis rosea is a common dermatologic disorder, information regarding the epidemiology of the disease in India is limited because of inadequate studies. The incidence and presentation of pityriasis rosea varies from one geographical region to another. The objective was to study the various clinical patterns of the disease and epidemiologic factors influencing its occurrence. A cross-sectional study on the clinicoepidemiologic pattern of pityriasis rosea was conducted. A detailed history of illness regarding onset, evolution, duration, symptoms, systemic features, recurrence, history of contact, and associated factors such as socioeconomic status, history of drug intake, and use of new clothing, along with epidemiologic data, was recorded in the performa. The age of the patients ranged from 3 to 47 (mean 20.32) years. Incidence of pityriasis rosea was highest among patients aged 11 to 20 years followed by those 21 to 30 years. There was a male preponderance. Seasonal variation was not evident. History of using new garments or old garments, unwashed for an extended period was elicited in 23% of cases. The average interval of onset of lesions and presentation to physician was 14.45 days. Pruritus was a common symptom (70%). Of 73 patients, 67 had herald patch. The clinical features of most of the cases were in accordance with the classical pattern of pityriasis rosea.

  15. Pityriasis versicolor in the pediatric age group

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    Jena Deepak

    2005-01-01

    Full Text Available BACKGROUND: Pityriasis versicolor (PV is a mild chronic infection of the skin caused by Malassezia yeasts. Although it is primarily seen in adults, children are often affected in the tropics . METHODS: Over a period of 2 years, children (up to the age of 14 years who were clinically and mycologically diagnosed as PV were included in the study. The clinical and epidemiological pattern in different age groups was noted. RESULTS: PV in this age group formed about 31% of the total cases of PV; 4.8% cases presented in infancy. The commonest site of involvement was the face in 39.9% of the cases. Most of the cases presented in summer months. CONCLUSIONS: PV is not an uncommon disease among children in the tropics. There is a sudden resurgence of cases in the hot monsoons and even infants are not spared.

  16. Pityriasis Rubra Pilaris In The Indian Scenario

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    Sarkar Rashmi

    2002-01-01

    Full Text Available Pityriasis rubra pilaris (PRP is an uncommon idiopathic papulosqamous disorder characterized by circumscribed follicular keratosis, palmoplantar keratoderma and frequently erythroderma. Seven patients of PRP (five females and two males in the age range of 2 to 50 years seen over a 2-year period are presented with their clinical features, triggering factors, associations and laboratory investigations. The clinical type of PRP was adult onset classical variety in three, juvenile circumscribed variety in two and adult onset atypical variety and juvenile classical variety in one each. The triggering factors were upper respiratory tract infection with nutritional deficiencies in two and folliculitis in one. The histopathology was consistent with PRP in all. Four patients were managed with oral vitamin A while one each was put on methotrexate, etretinate and topical steroids and they showed a good response. More number of cases should be studied over a longer period to substantiate the suggested immunologic mechanism of PRP.

  17. Acral pityriasis versicolor – A rare clinical presentation

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    Tasleem Arif

    2015-04-01

    Full Text Available Pityriasis versicolor is a superficial fungal infection of the skin caused by the yeast of the genus Malassezia and presents as hypo or hyper pigmented scaly macules. The most commonly affected sites include upper trunk, upper arms, neck and the abdomen. Lesions confined to the acral parts like hands and feet have rarely been reported. In this article the author reports a 40 year old male who presented with multiple hypo pigmented scaly macules confined to the acral parts (hands and wrist. The acral variant of pityriasis versicolor is considered to be a very rare clinical entity which prompted the author to report this case.

  18. Oral Alitretinoin for the Treatment of Recalcitrant Pityriasis Rubra Pilaris

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    Laurenz Schmitt

    2011-04-01

    Full Text Available Treatment of pityriasis rubra pilaris is still challenging. We here present a 74-year-old woman who had not experienced stable remission of her skin symptoms during prior treatments including topical and systemic corticosteroids, phototherapy, orally administered acitretin, cyclosporine, methotrexate and adalimumab. A therapy with oral alitretinoin was started and tolerated very well. After a few weeks, skin condition improved significantly and itching and scaling disappeared. The present case shows that alitretinoin might be an alternative in the treatment of recalcitrant pityriasis rubra pilaris type I. Further studies are needed to investigate the benefit of this encouraging result.

  19. Pityriasis rosea following influenza (H1N1 vaccination

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    Jeng-Feng Chen

    2011-06-01

    Full Text Available Pityriasis rosea is a distinct papulosquamous skin eruption that has been attributed to viral reactivation, certain drug exposures or rarely, vaccination. Herein, we reported a clinicopathlogically typical case of pityriasis rosea that developed after the H1N1 vaccination. With a global H1N1 vaccination program against the pandemic H1N1 influenza, patients should be apprised of the possibility of such rare but benign skin reaction to avoid unnecessary fear. Furthermore, a brief review of the current reported skin adverse events related to the novel H1N1 vaccination in Taiwan is presented here.

  20. Fluconazole in the therapy of Pityriasis versicolor

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    Poljački Mirjana N.

    2005-01-01

    Full Text Available The authors present the results of the systemic application of flukonazole in therapy of Pityriasis versicolor. It was arranged for the total number of 38 patients, 18 females and 20 males. The diagnosis of diseases was established on the base of the clinical examination, the native mycological examination and by the using of Wood lamps. The therapy was passed by the using of 300 mg flukonazole in a single dose, once weekly, during two weeks. The following period amounted to one week after the passed therapy. The therapeutic efficacy was assessed with regard to the clinical and mycological healing. The clinical efficacy was assessed semiquantitative on the base of increasing of the percentage rates of the total score of disease that was computed by collecting of the numeric values for every clinical argument typical for the disease, and the mycological efficacy on the base of the mycological findings and the fluorescence finding after lightening with the Wood's lamp. The controlling examinations were performed on day 0, 14 and 22. The results of investigations have shown that the complete clinical healing was achieved after two weeks of therapy in 94,74%, and the mycological healing in 92,11% patients. The rate of the mycological healing was evaluated after 1 week of following period equal to the rate of the clinical healing and it was also 94,74%. The undesirable effects of the drug applications weren't by any patient.

  1. Pitiríase Versicolor Pityriasis Versicolor

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    Josenildo Rodrigues de Oliveira

    2002-10-01

    Full Text Available A expressão pitiríase versicolor define uma infecção fúngica superficial caracterizada por alterações na pigmentação cutânea. O distúrbio de pigmentação é devido à colonização do estrato córneo por um fungo dimórfico, lipofílico, encontrado na flora normal da pele, conhecido como Malassezia furfur. Trata-se de doença prevalente nos trópicos, mas também comum em climas temperados. Há vários tratamentos disponíveis com taxas elevadas de cura, porém as recorrências são freqüentes.Pityriasis versicolor is a superficial fungal infection characterized by changes in skin pigment due to colonization of the stratum corneum by a dimorphic lipophilic fungus of the normal flora of the skin, known as Malassezia furfur. This disease is most prevalent in the tropics, but is also common in temperate climates. Treatment is available and cure rates are high, although recurrence is common.

  2. Narrowband UVB phototherapy in pityriasis rosea

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    Vijayeeta Jairath

    2015-01-01

    Full Text Available Objective: Pityriasis rosea (PR is an acute self-limiting disease. Despite vigorous efforts by generations of researchers since nearly 150 years, present treatment modalities for PR are not very gratifying. Ultraviolet radiation has been recommended in PR, although only a few studies validate this proposal. This study was conducted to explore the therapeutic effect of NBUVB on the symptoms, course, and severity of PR. Materials and Methods: This study involved a hundred patients who were randomly divided into two groups, using computer-generated randomization chart. Group A underwent treatment with fixed dose NBUVB of 250 mJ/cm2 three times (nonconsecutive a week for 4 weeks. Group B formed the placebo group who did not receive any treatment. The two groups were compared with each other for the intensity of pruritis, course and duration of disease, and PR severity score (PRSS. Results: The t values of improvement in PRSS score in Group A (t = 12.796 were higher as compared with that in Group B (t = 10.066. Similarly, the t value of the pruritus scale in Group A (t = 7.758 was higher than Group B (t = 5.754 indicating the symptomatic improvement in itching. Conclusion: Fixed-dose NBUVB phototherapy resulted in marked improvement in the severity and symptoms of the disease as quantitatively assessed by PRSS.

  3. Disruption of barrier function in dermatophytosis and pityriasis versicolor.

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    Lee, Weon Ju; Kim, Jun Young; Song, Chang Hyun; Jung, Hong Dae; Lee, Su Hyun; Lee, Seok-Jong; Kim, Do Won

    2011-11-01

    Dermatophytes have the ability to form molecular attachments to keratin and use it as a source of nutrients, colonizing keratinized tissues, including the stratum corneum of the skin. Malassezia species also affect the stratum corneum of the skin. Therefore, dermatophytosis and pityriasis versicolor of the skin are thought to be important factors of profound changes in skin barrier structure and function. We aimed to describe the changes in transepidermal water loss (TEWL), stratum corneum hydration, and skin pH in the lesions of the dermatophytosis and pityriasis versicolor. Thirty-six patients with dermatophytosis (14 with tinea cruris, 13 with tinea corporis and nine with tinea pedis or tinea manus) and 11 patients with pityriasis versicolor were included in this study. TEWL, stratum corneum conductance and skin pH were determined by biophysical methods to examine whether our patients exhibited changes in barrier function. Dermatophytosis and pityriasis versicolor except tinea pedis and tinea manus showed highly significant increase in TEWL compared with adjacent infection-free skin. Hydration was significantly reduced in lesional skin compared with adjacent infection-free skin. From this study, infections with dermatophytes and Malassezia species on the body can alter biophysical properties of the skin, especially the function of stratum corneum as a barrier to water loss. On the contrary, infections with dermatophytes on the palms and soles little affect the barrier function of the skin. © 2011 Japanese Dermatological Association.

  4. Atypical pityriasis rosea: clinical evaluation of 27 patients.

    Science.gov (United States)

    Kilinc, Fadime; Akbas, Ayse; Sener, Sertac; Aktaş, Akın

    2017-06-01

    Pityriasis rosea (PR) is a common, acute, self-limiting inflammatory skin disease. It can easily be recognized with its typical clinical presentation. However, unusual clinic presentations can cause difficulty in diagnosis. Up to now, not many atypical forms are reported. To determine the clinical characteristics of patients with atypical pityriasis rosea. A total of 27 cases, diagnosed as atypical PR by clinical and/or histopathological examination and applied to the outpatient clinic of dermatology department between the years 2007 and 2015 were analyzed retrospectively. The ages of patients ranged from 2 to 59 years. Of these patients, 15 (55.6%) were male and 12 (44.4%) were female. The male-to-female ratio was 5-4. Five patients had papular, four patients had purpuric, three patients had vesicular, two patients had follicular, one patient had erythema multiforme-like and one patient had eczematous drug-induced atypical form of pityriasis rosea. There were 12 cases of localized, two cases of segmental pityriasis rosea. Four of the localized forms also had atypical morphology. Histopathological evaluation was required for diagnosis in 12 (44.4%) patients. PR can appear in many different uncommon forms. Localization and skin rush can be misleading and diagnosis can be compelling.

  5. [Pityriasis versicolor in Greece and its predisposition factors].

    Science.gov (United States)

    Parisis, N; Stratigos, J; Marcelou-Kinti, U; Capetanakis, J

    1977-11-01

    The age and seasonal incidence of 2610 patients with pityriasis versicolor in Greece were studied. Determination of the pH of Na and K ions of the sweat and the microbiol flora of the skin of pityriasis versicolor patients was undertaken. Besides these the effectiveness of a 1% selenium disulfid suspension was tested. The results indicate that the age groups of 20-29 and 30-30 years are mostly affected by the disease. A high incidence of the skin manifestation was noted during the summer and fall months. A difference of the pH of the sweat between pityriasis versicolor and healthy controls was observed, but no difference was found in the Na and K ions of the sweat among these two groups. Neither did the microbial flora from the skin lesions of patients and from corresponding sites of controls show any difference. The high relapse in this experiment indicates the relative ineffectiveness of selenium disulfid preparations when used as a 1% suspension in the treatment of pityriasis versicolor.

  6. Influence of systemic corticotherapy on the triggering of pityriasis versicolor.

    Science.gov (United States)

    da Fraga, Clarissa Matarangas Moreira; de Cássia Birschiner, Rita; Naseri, Alice Pignaton; Diniz, Lucia Martins

    2014-09-01

    Pityriasis versicolor is a frequent mycosis and the use of systemic corticotherapy is one of its predisposing factors. This is an observational, cross-sectional, analytical and comparative study, conducted from January 2012 to January 2013 in the following outpatient clinics: Dermatology Service, Cassiano Antonio Moraes Hospital (HUCAM), Vitória, ES, Brazil; Nephrology Service, HUCAM; and Leprosy Department, Maruípe Health Unit, Vitória, ES, Brazil. Patients, undergoing long-term systemic corticotherapy (or not), were assessed with respect to the presence of pityriasis versicolor. If there was mycosis, a direct mycological examination would be carried out. The spss 17.0 software was used for the statistical analysis. From the total of 100 patients, nine had pityriasis versicolor, being eight from the corticotherapy group and one from the group with no use of corticosteroids. Regarding the patients with mycosis, the prevalent age ranged from 20 to 39 years, with six patients; six were women; seven mixed race; eight were undergoing long-term systemic corticotherapy; seven were taking low-dose systemic corticosteroids; four had leucocytosis; five had normal total cholesterol and triglycerides; and four had normal glycaemia. There was increased frequency of pityriasis versicolor in the group undergoing systemic corticotherapy with statistical significance, corroborating the only study on the topic (1962).

  7. Pityriasis versicolor: avoiding pitfalls in disease diagnosis and therapy.

    Science.gov (United States)

    Rivard, Shayna C

    2013-08-01

    Pityriasis versicolor is common among young active duty members with overactive sweat glands working in humid environments and results in pigmentary changes that can be profound in those with darker skin. This article addresses several issues related to making the correct diagnosis and providing appropriate treatment, as well as the specific challenges military providers may face in these cases.

  8. Pityriasis Lichenoides Chronica Associated with Herpes Simplex Virus Type 2

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    Antonio Javier González Rodríguez

    2012-01-01

    Full Text Available Introduction. Pityriasis lichenoides is a rare, acquired spectrum of skin conditions of an unknown etiology. Case Report. A 28-year-old man presented with recurrent outbreaks of herpes simplex virus associated with the onset of red-to-brown maculopapules located predominantly in trunk in each recurrence. Positive serologies to herpes simplex virus type 2 were detected. Histopathological examination of one of the lesions was consistent with a diagnosis of pityriasis lichenoides chronica. Discussion. Pityriasis lichenoides is a rare cutaneous entity of an unknown cause which includes different clinical presentations. A number of infectious agents have been implicated based on the clustering of multiple outbreaks and elevated serum titers to specific pathogens (human immunodeficiency virus, cytomegalovirus, Epstein-Barr virus, Toxoplasma gondii, and herpes simplex virus. In our patient, resolution of cutaneous lesions coincided with the administration of antiviral drugs and clinical improvement in each genital herpes recurrence. In conclusion, we report a case in which cutaneous lesions of pityriasis lichenoides chronica and a herpes simplex virus-type 2-mediated disease have evolved concomitantly.

  9. Predisposing factors on the surface of the skin in persons with pityriasis versicolor.

    Science.gov (United States)

    Gloor, M; Kümpel, D; Friederich, H C

    1975-12-31

    This is a report on biochemical and physiological examinations carried out on 20 test persons who in the last 2 years had contacted and completely recovered from pityriasis versicolor and on 25 control persons of corresponding age and sex. The tests on the skin surface of the patients with pityriasis versicolor show, when compared with the corresponding control group, the following significant results: 1. Significantly more amino acids could be extracted from the skin of the pityriasis versicolor patients than from the skin of the control persons. 2. A significantly shorter alkali neutralisation time was to be found in the pityriasis versicolor patients than in the control persons. 3. The degree of water spreading on the skin was found to be significantly reduced in the pityriasis versicolor patients when compared with the control persons. It is probable that these results point to important predisposing factors for pityriasis versicolor.

  10. Tissue immunostaining for factor XIIIa in dermal dendrocytes of pityriasis alba skin lesions

    OpenAIRE

    Carneiro, Francisca Regina Oliveira; Amaral,Gabriela Borborema do; Mendes,Maiana Darwich; Quaresma,Juarez Antônio Simões

    2014-01-01

    BACKGROUND: Pityriasis alba affects 1% of the world population and about 9.9% of the children in Brazil. However, its etiology remains uncertain. OBJECTIVE: The objective of the present study was to evaluate the immunoexpression of factor XIIIa in dermal dendrocytes of skin lesions of pityriasis alba. METHOD: Twenty patients with pityriasis alba and 20 patients with atopic dermatitis underwent biopsy. The dermal dendrocytes marked by factor XIIIa were counted by means of immunohistochemic...

  11. Clinicomycological profile of pityriasis versicolor in Assam

    Directory of Open Access Journals (Sweden)

    Ajanta Sharma

    2016-01-01

    Full Text Available Background: Geographical variation in the distribution of Malassezia species associated with pityriasis versicolor (PV has led to the necessity of studying epidemiological, mycological, and clinical characteristics of PV. Aims: To study the epidemiological, mycological, and clinical characteristics of PV in a tertiary care hospital. Settings and Design: The study was carried out with a cross-sectional design. Materials and Methods: Two hundred and sixty-two consecutive PV patients were subjected to detailed history, clinical examination, and investigations. Skin scrapings were processed by direct microscopy and culture. Isolates were identified by phenotypic characteristics and polymerase chain reaction-restriction fragment length polymorphism. Association of Malassezia species with clinical and epidemiological characteristics was studied. Statistical analysis of the data was done using statistical software. Results: Maximum number of PV cases (33.9% belonged to the age group of 21–30 years with a male preponderance. 61.4% of the patients had a sedentary lifestyle, 70.2% showed the gradual onset of the disease, 51.1% presented with pruritus and in 66.4% of the patients symptoms were continuous. Most commonly involved body site was neck (27.8%, 77.09% of the lesions were bilaterally asymmetrical, 87.4% were macular, and 89.3% were hypopigmented. Malassezia furfur (77.3% was the predominant species. Sedentary lifestyle (61.4% and increased sweating (48% were the most commonly associated predisposing factors. Conclusion: PV is more common in males. Distribution of Malassezia species varies significantly from those reported in other parts of India. M. furfur was the most common species responsible for PV in our region. Hence, further studies are required to evaluate the exact cause of this variation.

  12. A case of Pityriasis rosea concurrent with the novel influenza A (H1N1) infection.

    Science.gov (United States)

    Mubki, Thamer F; Bin Dayel, Salaman A; Kadry, Razan

    2011-01-01

    Pityriasis rosea is a common skin disease with a self-limiting course. Multiple etiologies including viruses, bacteria, and fungi have been investigated in an attempt to confirm a casual association. Pityriasis rosea has not been associated with influenza virus, but has been associated with herpes simplex virus types 6 and 7. We encountered a case of a proven pandemic H1N1 infection associated with a clincopathological diagnosis of pityriasis rosea. We conclude that influenza A (H1N1) virus could either be a primary cause of pityriasis rosea or a trigger for reactivation of other viral causes. © 2011 Wiley Periodicals, Inc.

  13. ORIGINAL ARTICLE : Skin Characteristics in Patients with Pityriasis Versicolor Using Non-Invasive Method, MPA5

    National Research Council Canada - National Science Library

    Hyun Jung Park; ; Yang Won Lee; Yong Beom Choe; Kyu Joong Ahn

    2012-01-01

    Background: Skin pigmentary changes of pityriasis versicolor may occur as either hyperpigmented or hypopigmented lesions, depending on the outcome of interactions between Malassezia yeasts and the skin...

  14. Pityriasis rosea like drug rash - a need to identify the disease in childhood.

    Science.gov (United States)

    Panda, Maitreyee; Patro, Nibedita; Jena, Monalisa; Dash, Mrutunjay; Mishra, Swati

    2014-08-01

    Pityriasis rosea is a common dermatosis named by Gibert in 1860. It is an acute self limiting papulosquamous disease, probably infective in origin affecting healthy adolescents and young adults. It is characterized by distinctive skin eruptions and minimal constitutional symptoms. Drug induced pityriasis rosea tend to occur in older generation and resolution seen only after withdrawal of the offending drug. We report a case of 12-year-old boy with erythematous papules distributed over trunk and proximal arms after nimesulide therapy consistent with a clinical diagnosis of atypical pityriasis rosea. The relation of drug and development of pityriasis rosea is confirmed by dechallenge test of the suspected drug.

  15. Pityriasis Rosea Like Drug Rash – A Need to Identify the Disease in Childhood

    Science.gov (United States)

    Patro, Nibedita; Jena, Monalisa; Dash, Mrutunjay; Mishra, Swati

    2014-01-01

    Pityriasis rosea is a common dermatosis named by Gibert in 1860. It is an acute self limiting papulosquamous disease, probably infective in origin affecting healthy adolescents and young adults. It is characterized by distinctive skin eruptions and minimal constitutional symptoms. Drug induced pityriasis rosea tend to occur in older generation and resolution seen only after withdrawal of the offending drug. We report a case of 12-year-old boy with erythematous papules distributed over trunk and proximal arms after nimesulide therapy consistent with a clinical diagnosis of atypical pityriasis rosea. The relation of drug and development of pityriasis rosea is confirmed by dechallenge test of the suspected drug. PMID:25302254

  16. Gestational Pityriasis Rosea: Suggestions for Approaching Affected Pregnant Women.

    Science.gov (United States)

    Monastirli, Alexandra; Pasmatzi, Efstathia; Badavanis, George; Tsambaos, Dionysios

    2016-12-01

    Dear Editor, Pityriasis rosea is a common, acute, and self-limiting dermatosis, which is associated with the endogenous systemic reactivation of human herpesvirus (HHV)-6 and/or HHV-7 (1). It predominantly affects individuals of both sexes in their second or third decade of life and is clinically characterized by the occurrence of an initial erythematosquamous plaque followed by the appearance of disseminated similar but smaller lesions one or two weeks later. Several patients develop systemic symptoms such as nausea, anorexia, malaise, headache, fever, arthralgia, and lymphadenopathy that may precede or accompany the eruption; the latter follows the cleavage lines of the trunk creating the configuration of a Christmas tree and spontaneously resolves within 4 to 8 weeks. Mainly based on the nature of the underlying viral reactivation, pityriasis rosea is classified into five different forms (2): 1) Classic and 2) Relapsing (characterized by sporadic and relapsing HHV-6/7 systemic reactivation, respectively), 3) Persistent (persistence of HHV-6/7 viremia), 4) Pediatric (longer activity of HHV-6/7 infection; recent primary infection) and 5) Gestational (HHV-6/7 reactivation and possible intrauterine transmission). Clearly, the inevitable impairment of immune response in pregnancy favors viral reactivation and possibly also the intrauterine transmission of HHV-6/7. Indeed, it is well known and documented that pityriasis rosea more frequently occurs in pregnant women (18%) as compared to the general population (6%) (3). However, the literature concerning the possible effect of pityriasis rosea on the outcome of pregnancy is surprisingly sparse. Only an Italian group, Drago et al (4,5), has systematically investigated the impact of this disorder on pregnant women. They found that 22 out of 61 women (36%) who developed pityriasis rosea during pregnancy had unfavorable outcomes, whereas 8 others miscarried (13%). None of the latter had any risk factors, other than

  17. Nomenclature of drug-induced pityriasis rosea-like rashes

    Directory of Open Access Journals (Sweden)

    Chuh AAT

    2015-10-01

    Full Text Available Antonio AT Chuh1Prince of Wales Hospital, Hospital Authority, 2The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong KongI read with admiration an article published in your prestigious journal on the rare adverse effects of clozapine (CLZ.1I write to address a specific issue in this article. In the second paragraph of the section “Dermatological adverse effects”, it was stated that a 54-year-old patient with schizophrenia treated for 28 days with CLZ developed a generalized rash compatible with pityriasis rosea (skin rash that usually begins as one large circular or oval spot on your chest, abdomen, or back.I wish to point out certain problems for coining pityriasis rosea (PR as the diagnostic label in the patient concerned.View original paper by De Fazio and colleagues.

  18. Pityriasis Versicolor on Penile Shaft in a Renal Transplant Recipient

    Science.gov (United States)

    Ryu, Han-Won; Cho, Jae-We

    2012-01-01

    Pityriasis versicolor is a superficial infection of the stratum corneum, which is caused by the Malassezia species. Tge Malassezia species consist of 12 subspecies, including M. furfur, M. pachydermatis, M. symphodialis and M. globasa. The Malassezia species are classified as a normal flora, particularly in the sebum rich areas of the skin, and they convert from saprophytic yeast to parasitic mycelial morpholgic form to cause clinical disease. But majorities of their distributions are in the upper back, the neck, the thighs, and the forearm, and not in the penis. It is well known that the renal transplant patients, who take immunosuppressive agents, have impairment in the protective cell mediated immunity. Thus, they are more susceptible to infectious diseases, such as a fungal infection. Therefore, clinical manifestations show higher incidence of disease, but they mostly occur in an expected distribution. We here report a case of pityriasis versicolor in a renal transplant recipient on penile shaft, which is an unusual area. PMID:22879720

  19. Pityriasis rosea in 12-months-old infant

    Directory of Open Access Journals (Sweden)

    Piotr Brzezinski

    2012-04-01

    Full Text Available Pityriasis Rosea (PR is a self-limiting papulo-squamous disorder characterized in its typical form by sudden onset of a larger scaly plaque (herald plaque, followed by multiple, bilateral smaller scaly lesions of oval or round shape which follow Langer’s lines of cleavage on the trunk and proximal parts of extremities.Currently accepted hypothesis that the cause of this disease are human herpesvirus: HHV-6 and HHV-7.Presented case of 12-months-old infant with the image of a pityriasis rosea.PR is a common skin condition seen in children and adults. PR is rarely diagnosed in infants. It is important to distinguish it from other childhood exanthems.

  20. Pityriasis versicolor on penile shaft in a renal transplant recipient.

    Science.gov (United States)

    Ryu, Han-Won; Cho, Jae-We; Lee, Kyu-Suk

    2012-08-01

    Pityriasis versicolor is a superficial infection of the stratum corneum, which is caused by the Malassezia species. Tge Malassezia species consist of 12 subspecies, including M. furfur, M. pachydermatis, M. symphodialis and M. globasa. The Malassezia species are classified as a normal flora, particularly in the sebum rich areas of the skin, and they convert from saprophytic yeast to parasitic mycelial morpholgic form to cause clinical disease. But majorities of their distributions are in the upper back, the neck, the thighs, and the forearm, and not in the penis. It is well known that the renal transplant patients, who take immunosuppressive agents, have impairment in the protective cell mediated immunity. Thus, they are more susceptible to infectious diseases, such as a fungal infection. Therefore, clinical manifestations show higher incidence of disease, but they mostly occur in an expected distribution. We here report a case of pityriasis versicolor in a renal transplant recipient on penile shaft, which is an unusual area.

  1. Depigmented lesions of pityriasis versicolor: A diagnostic dilemma with review of literature

    OpenAIRE

    Tejinder Kaur; Daljit Singh; Suresh K Malhotra; Arashbir Kaur

    2017-01-01

    Pityriasis versicolor is a superficial mycosis affecting the skin. It is caused by malassezia species of fungi. Common sites of involvement are chest, neck and shoulders. We report a rare case of pityriasis versicolor affecting both arms and dorsum of both hands but sparing the commonly involved sites and masquerading vitiligo.

  2. Depigmented lesions of pityriasis versicolor: A diagnostic dilemma with review of literature

    Directory of Open Access Journals (Sweden)

    Tejinder Kaur

    2017-04-01

    Full Text Available Pityriasis versicolor is a superficial mycosis affecting the skin. It is caused by malassezia species of fungi. Common sites of involvement are chest, neck and shoulders. We report a rare case of pityriasis versicolor affecting both arms and dorsum of both hands but sparing the commonly involved sites and masquerading vitiligo.

  3. Follicular pityriasis versicolor-Rare variant of a common dermatological disease

    OpenAIRE

    Tasleem Arif; Shagufta Rather

    2015-01-01

    Pityriasis versicolor is a superficial fungal infection of the skin caused by yeast of the genus Malassezia. It is characterized by hypopigmented or hyperpigmented macules and patches usually involving the trunk [1]. The variants of pityriasis versicolor include hypochromic, hyperchromic, combination of hypo-hyperchromic, erythematous, circinate, atrophic and acral [2-4].

  4. Follicular pityriasis versicolor-Rare variant of a common dermatological disease

    Directory of Open Access Journals (Sweden)

    Tasleem Arif

    2015-01-01

    Full Text Available Pityriasis versicolor is a superficial fungal infection of the skin caused by yeast of the genus Malassezia. It is characterized by hypopigmented or hyperpigmented macules and patches usually involving the trunk [1]. The variants of pityriasis versicolor include hypochromic, hyperchromic, combination of hypo-hyperchromic, erythematous, circinate, atrophic and acral [2-4].

  5. Comparative histopathology of Pityriasis versicolor and Pityrosporum folliculitis

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    Mittal R

    1992-01-01

    Full Text Available Twenty five cases each of pityriasis versicolor (PV and pityrosporum folliculitis (PF were selected for this study. Histopathologically in PV, spores and hyphae in spaghetti and meatball appearance in stratum corneum, and perivascular mononuclear infiltrate were seen. In PF, spores were inside the dilated hair follicles filled with keratin, perifollicular and perivascular mononuclear infiltration were seen. Basket weave hyperkeratosis, edema and disruption of collagen were seen in 88% cases of PF and have not been reported earlier.

  6. Successful treatment of pityriasis rubra pilaris with adalimumab - case report.

    Science.gov (United States)

    Bravo, Erick A; Carrion, Leonidas; Paucar, Silvia M; Mendoza, Rossana; Rivera, Carlos

    2014-04-16

    Pityriasis Rubra Pilaris (PRP) is an uncommon skin disorder characterized by follicular keratosis, palmoplantar keratoderma, and erythroderma. The traditional preferred treatment is oral retinoids, but over the last decade, biologic therapy with anti-TNF agents has been used with success. We report the case of a 51 year- old man with a clinical and histopathological diagnosis of PRP. He underwent therapy with adalimumab and showed clearance of skin lesions within the fourth week of treatment.

  7. Childhood Pityriasis rosea inversa without Herald Patch Mimicking Cutaneous Mastocytosis

    OpenAIRE

    Pelin Ertan; Aykan Özgüven; Aylin Türel Ermertcan; Cemal Bilaç; Peyker Temiz

    2010-01-01

    Background:Pityriasis rosea is a self-limited inflammatory condition of the skin that mostly affects young adults. Several less common atypical presentations have been reported. Case Presentation:A 6-year old girl with red-brown maculopapular eruption sized 0, 5-1 cm in diameter localized on neck, trunk and popliteal region visited our general pediatric outpatient clinic. The eruption was wide spread especially on flexural areas. After consulting dermatologist skin biopsy was performed. Accor...

  8. [Myerson nevus as a primary patch of Gibert pityriasis rosea. A case report].

    Science.gov (United States)

    Hofer, T

    2002-05-01

    There are only few articles in literature which discuss the association between Meyerson's naevi and Pityriasis rosea. And when so, the discussion is done in a controversial way. Here an 18 year old man is presented who visits the outpatient clinic. He has a ten day history of a solitary Meyerson's naevus on his back. Over the next three weeks this naevus will develop to the typical herold patch followed by the classical exantheme of Pityriasis rosea. Halo dermatitis associated with Pityriasis rosea don't represent Meyerson's naevi. But they reflect the rare "nevocentric" property of a not so rare dermatose.

  9. Localised pityriasis rosea-like eruption during radiotherapy. Report of 2 cases.

    Science.gov (United States)

    Moloney, Gary R; Goh, Michelle S Y; Mitchell, Catherine; McCormack, Chris J

    2015-11-01

    Pityriasis rosea is a common skin condition that presents acutely with asymptomatic, scaly and oval plaques, usually in a well-recognised distribution over the trunk. Two men developed ovoid, scaly and annular lesions limited to the radiotherapy field during treatment for pelvic malignancies and without a preceding herald patch. Other causes of the eruption were excluded on clinical and pathological grounds and the histopathological features were consistent with a pityriasis rosea-like eruption. In both cases the lesions resolved spontaneously by 8 weeks. These are the first reported cases of a localised pityriasis rosea-like eruption arising during radiotherapy. © 2014 The Australasian College of Dermatologists.

  10. Identification of Malassezia yeast species isolated from patients with pityriasis versicolor.

    Science.gov (United States)

    Petry, Vanessa; Tanhausen, Fernanda; Weiss, Luciana; Milan, Thais; Mezzari, Adelina; Weber, Magda Blessmann

    2011-01-01

    Pityriasis versicolor (PV) is a disease with worldwide distribution. Twelve different species of Malassezia yeast have been described. The objective of this study was to determine which species of Malassezia are more prevalent in patients with pityriasis versicolor. Samples were collected by scraping the lesions of 87 patients with a clinical suspicion of pityriasis versicolor. The samples were then submitted to fungal microscopy and culture to identify the species. The species found were: Malassezia sympodialis (30%), Malassezia furfur (25.7%), Malassezia globosa (22.7%), Malassezia restricta (12.1%), Malassezia obtusa (7.6%) and Malassezia slooffiae (1.5%).

  11. Pityriasis rosea with erythema multiforme - like lesions: An observational analysis

    Directory of Open Access Journals (Sweden)

    Vineet Relhan

    2013-01-01

    Full Text Available Pityriasis rosea (PR is an acute or subacute inflammatory skin disease characterized by erythematous papulosquamous eruptions localized on the trunk and arms. The eruptions are self-limiting and usually disappear gradually in 2-10 weeks, without any treatment. Typical PR is much easier to diagnose than the rare atypical forms. There is a passing mention of PR with erythema multiforme-like lesions in the literature, but no extensive case series have been published till date. We present a series of five patients for whom we believe atypical PR is the likely diagnosis.

  12. Pityriasis rubra pilaris: treatment with biologics - a new promising therapy?

    Science.gov (United States)

    Ivanova, Katja; Itin, Peter; Haeusermann, Peter

    2012-01-01

    Pityriasis rubra pilaris (PRP) includes a spectrum of rare chronic inflammatory disorders with papulosquamous eruptions of unknown cause. Different etiologies have been proposed such as vitamin A metabolism dysfunction, association with autoimmune disorders, infection or malignancies. However, PRP seems to be a polygenic skin disorder. Classical systemic treatment is empirical and includes retinoids and methotrexate; however, only few series on treatments exist. Recently there has been an increasing number of reports documenting that new biologicals and in particular TNF-α blockers are safe and effective. Copyright © 2012 S. Karger AG, Basel.

  13. Pityriasis rosea-like eruptions due to mustard oil application

    Directory of Open Access Journals (Sweden)

    Zawar Vijay

    2005-01-01

    Full Text Available A young man employed in a construction company, presented with cutaneous lesions clinically simulating pityriasis rosea. Satisfactory and complete response to corticosteroids and antihistamines was followed by recurrence. Multiple recurrences within a short span of time arose a suspicion of alternative diagnosis. Site visit helped us to rule out occupational contact dermatitis. Further history taking revealed that he was recently using mustard oil for body massage. Subsequent patch testing confirmed contact hypersensitivity to mustard oil. Avoidance of the contact with mustard oil arrested appearance of further skin lesions. We stress the importance of taking a good history in clinical practice in disclosing a possible contactant.

  14. Tissue immunostaining for factor XIIIa in dermal dendrocytes of pityriasis alba skin lesions

    National Research Council Canada - National Science Library

    Carneiro, Francisca Regina Oliveira; Amaral, Gabriela Borborema do; Mendes, Maiana Darwich; Quaresma, Juarez Antônio Simões

    2014-01-01

    .... However, its etiology remains uncertain. OBJECTIVE: The objective of the present study was to evaluate the immunoexpression of factor XIIIa in dermal dendrocytes of skin lesions of pityriasis alba. METHOD...

  15. Pityriasis versicolor: an update on pharmacological treatment options.

    Science.gov (United States)

    Gupta, Aditya K; Lyons, Danika C A

    2014-08-01

    Pityriasis versicolor (PV) is a superficial fungal infection caused by Malassezia species; a yeast that naturally colonizes on the skins surface. High efficacy rates are generally obtained with both topical and systemic treatments. However, recurrence rates following successful treatment remain high and there are no dosage guidelines available for administration of systemic antifungal agents that carry risks of adverse events. This review focused on providing an overview of existing treatments for PV and an introduction to new treatments. A literature search was conducted using the search strategy, pityriasis versicolor OR tinea versicolor. Over the past decade, few new treatments have been introduced, but the efficacy and the dosing regimens of existing treatments have been systematically reviewed. The results of these reviews are discussed. Existing topical and systemic agents are both effective treatments against PV. Previous dosage recommendations for systemic agents have been modified based on recent evidence elucidated in systematic reviews. However, the absence of standardized collection and reporting practices in clinical trials precludes any conclusions to be drawn regarding the efficacy and safety of topical and systemic agents in comparison or in concert with each other.

  16. Pityriasis alba revisited: perspectives on an enigmatic disorder of childhood.

    Science.gov (United States)

    Jadotte, Yuri T; Janniger, Camila K

    2011-02-01

    Pityriasis alba (PA) is a localized hypopigmented disorder of childhood with many existing clinical variants. It is more often detected in individuals with a darker complexion but may occur in individuals of all skin types. Atopy, xerosis, and mineral deficiencies are potential risk factors. Sun exposure exacerbates the contrast between normal and lesional skin, making lesions more visible and patients more likely to seek medical attention. Poor cutaneous hydration appears to be a common theme for most risk factors and may help elucidate the pathogenesis of this disorder. The end result of this mechanism is inappropriate melanosis manifesting as hypopigmentation. It must be differentiated from other disorders of hypopigmentation, such as pityriasis versicolor alba, vitiligo, nevus depigmentosus, and nevus anemicus. Alleviation of the various risk factors via patient education on proper skin care and hygiene, use of lubricants and emollients, topical corticosteroid therapy in the presence of inflammation, and the novel administration of topical anti-inflammatory drugs such as calcineurin inhibitors can play a crucial role in promoting remission or resolution.

  17. Skin Characteristics in Patients with Pityriasis Versicolor Using Non-Invasive Method, MPA5

    OpenAIRE

    Park, Hyun Jung; Lee, Yang Won; Choe, Yong Beom; Ahn, Kyu Joong

    2012-01-01

    Background Skin pigmentary changes of pityriasis versicolor may occur as either hyperpigmented or hypopigmented lesions, depending on the outcome of interactions between Malassezia yeasts and the skin, such as lipoperoxidation process, stimulus of inflammatory cell to melanocytes, and increased thickness of keratin layer. Objective To investigate skin characteristic factors that enhance the susceptibility to Malassezia yeasts and provoke different color changes of pityriasis versicolor patien...

  18. Pityriasis Rosea Like Drug Rash – A Need to Identify the Disease in Childhood

    OpenAIRE

    Panda, Maitreyee; Patro, Nibedita; Jena, Monalisa; Dash, Mrutunjay; Mishra, Swati

    2014-01-01

    Pityriasis rosea is a common dermatosis named by Gibert in 1860. It is an acute self limiting papulosquamous disease, probably infective in origin affecting healthy adolescents and young adults. It is characterized by distinctive skin eruptions and minimal constitutional symptoms. Drug induced pityriasis rosea tend to occur in older generation and resolution seen only after withdrawal of the offending drug. We report a case of 12-year-old boy with erythematous papules distributed over trunk a...

  19. The evaluation of local oxidative/nitrosative stress in patients with pityriasis versicolor: a preliminary study.

    Science.gov (United States)

    Kurutas, Ergul Belge; Ozturk, Perihan

    2016-11-01

    Yeast of Malassezia, members of the microbiologic flora of the skin, cause pityriasis versicolor and have also been implicated in the pathogenesis of other superficial dermatoses. The mechanisms by which the yeast cause these dermatoses, however, are not yet clear, and there have been no studies on the interaction between fungi and keratinocytes, especially the effects of fungi on the production of reactive oxygen/nitrogen species by human keratinocytes. This is the first study we aimed to evaluate the role of oxidative/nitrosative stress in affected skin areas in patients with pityriasis versicolor. Sixty pityriasis versicolor patients and 60 healthy subjects as control group were enrolled. Scraping samples were obtained from the lesional skin areas in patients and from the normal skin areas in controls. The distribution of lesions of pityriasis versicolor was mild in all patients. We have isolated two Malassezia species: M. furfur being isolated in 75% of patients, followed by M. globosa (25%). The levels of oxidative/nitrosative stress biomarkers were significantly higher in patients than the controls (P pityriasis versicolor is associated with significant alteration in oxidant/antioxidant balance. It might be secondary consequence of pityriasis versicolor infection or contributing factor in its pathogenesis. © 2016 Blackwell Verlag GmbH.

  20. Tissue immunostaining for factor XIIIa in dermal dendrocytes of pityriasis alba skin lesions*

    Science.gov (United States)

    Carneiro, Francisca Regina Oliveira; do Amaral, Gabriela Borborema; Mendes, Maiana Darwich; Quaresma, Juarez Antônio Simões

    2014-01-01

    BACKGROUND Pityriasis alba affects 1% of the world population and about 9.9% of the children in Brazil. However, its etiology remains uncertain. OBJECTIVE The objective of the present study was to evaluate the immunoexpression of factor XIIIa in dermal dendrocytes of skin lesions of pityriasis alba. METHOD Twenty patients with pityriasis alba and 20 patients with atopic dermatitis underwent biopsy. The dermal dendrocytes marked by factor XIIIa were counted by means of immunohistochemical analysis. RESULTS The mean amount of dermal dendrocytes found in the patients with pityriasis alba was 2, whereas in the patients with atopic dermatitis it was 4, with a statistically significant difference between them. A cutoff point of 3 cells/square inch was established to differentiate pityriasis alba from atopic dermatitis, with 80% sensibility and 90% specificity. CONCLUSION We believe that pityriasis alba and atopic dermatitis should be considered different clinical forms within the spectrum of atopic disease, in which sun radiation plays an important role by modulating the progression of the disease. PMID:24770500

  1. Tissue immunostaining for factor XIIIa in dermal dendrocytes of pityriasis alba skin lesions.

    Science.gov (United States)

    Carneiro, Francisca Regina Oliveira; Amaral, Gabriela Borborema do; Mendes, Maiana Darwich; Quaresma, Juarez Antônio Simões

    2014-01-01

    Pityriasis alba affects 1% of the world population and about 9.9% of the children in Brazil. However, its etiology remains uncertain. The objective of the present study was to evaluate the immunoexpression of factor XIIIa in dermal dendrocytes of skin lesions of pityriasis alba. Twenty patients with pityriasis alba and 20 patients with atopic dermatitis underwent biopsy. The dermal dendrocytes marked by factor XIIIa were counted by means of immunohistochemical analysis. The mean amount of dermal dendrocytes found in the patients with pityriasis alba was 2, whereas in the patients with atopic dermatitis it was 4, with a statistically significant difference between them. A cutoff point of 3 cells/square inch was established to differentiate pityriasis alba from atopic dermatitis, with 80% sensibility and 90% specificity. We believe that pityriasis alba and atopic dermatitis should be considered different clinical forms within the spectrum of atopic disease, in which sun radiation plays an important role by modulating the progression of the disease.

  2. Pityriasis Rubra Pilaris in a 3-Year-Old Male.

    Science.gov (United States)

    Stacey, Stephen K; Novek, Steven J; Maddox, Craig L

    2016-03-01

    A 3-year-old male presented with progressive pruritic red-orange plaques across most of his body with erythema, desquamation, and fissuring of the hands and feet. He was diagnosed with classic juvenile (type III) pityriasis rubra pilaris (PRP) and treated with oral isotretinoin for 6 months. His skin findings resolved quickly during the treatment period, with residual postinflammatory hypopigmentation resolving within a year. PRP is rare in pediatric patients and standard recommended treatment algorithms for this population are not currently available. Diagnostic and treatment guidelines for PRP are based almost exclusively on case reports or case series, most of which focus on adult patients. The presentation, evaluation, and management of PRP are discussed. Reprint & Copyright © 2016 Association of Military Surgeons of the U.S.

  3. Pityriasis rosea-like drug reaction to asenapine.

    Science.gov (United States)

    Makdisi, Joy; Amin, Bijal; Friedman, Adam

    2013-09-01

    Pityriasis rosea (PR) is a relatively common, benign skin disease of unknown etiology. In rare cases, medications can induce a morphologically similar eruption. We present a case of a PR-like drug eruption caused by the atypical antipsychotic asenapine. The clinical presentation consisted of a rapidly progressive, disseminated, and severely pruritic dermatitis comprised of ovoid, scaly, pink-violaceous plaques. The initial histopathologic specimen was consistent with PR, but upon re-sampling a week later, the findings favored a drug eruption. PR-like drug eruptions, though rare, can occur in response to a wide variety of medications. Because the findings may be only subtly different than those of typical PR, careful clinical and histopathological correlation must be sought. To our knowledge, this is the first reported case of a PR-like drug eruption to asenapine.

  4. Immunological study of Pityriasis versicolor and Pityrosporum folliculitis

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    Mittal R

    1992-01-01

    Full Text Available Twenty five cases of pityriasis versicolor and 25 cases of pityrosporum folliculitis were selected for this study. Skin scrapings in 10% potassium hydroxide showed spores and hyphae in all 25 cases of PV. Smears from PF showed Gram positive spores in all 25 cases and in addition few short hyphae in 3 cases. Initially IgM and Later both IgM and IgG were raised. Similar response was seen in PF initially and later IgM, IgG and IgA all were raised in PF. Though antibody levels were slightly higher in PF, yet basically the pattern was similar in PV and PF.

  5. Study of oral Ketoconazole on recurrent & extensive Pityriasis Versicolor

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    Moghaddami M

    1997-04-01

    Full Text Available Several topical agents have been used for treating Pityriasis versicolor. But the main problem is recurrence. In this study 82 patients with recurrent and/or extensive from of infection were treated with oral Ketoconazole. 200 mg once daily for a maximum of 4 weeks. Seventeen patients have been infected for the first time and sixty five for the several times. The duration of disease in most cases (35.4% were between 1-3 years. Out of 82 studied patients only 60 cases were referred for follow up. The clinical and mycological cure were seen in 54 cases (90% after 15 days therapy. In other 6 patients after 15 days the lesions have not cured completely so the treatment was continued for other 2 weeks, but after that, only one of them referred to the clinic, which treatment extended with topical therapy.

  6. Skin Characteristics in Patients with Pityriasis Versicolor Using Non-Invasive Method, MPA5.

    Science.gov (United States)

    Park, Hyun Jung; Lee, Yang Won; Choe, Yong Beom; Ahn, Kyu Joong

    2012-11-01

    Skin pigmentary changes of pityriasis versicolor may occur as either hyperpigmented or hypopigmented lesions, depending on the outcome of interactions between Malassezia yeasts and the skin, such as lipoperoxidation process, stimulus of inflammatory cell to melanocytes, and increased thickness of keratin layer. To investigate skin characteristic factors that enhance the susceptibility to Malassezia yeasts and provoke different color changes of pityriasis versicolor patients. To clarify these factors, we investigated the skin characteristics of pityriasis versicolor patients, using a non-invasive method known as MPA 5® (Courage and Khazaka, Germany). A total of 90 normal healthy subjects and 30 pityriasis versicolor patients were included in this study. Both hyperpigmented and hypopigmented pityriasis versicolor skin lesions showed higher humidity, increased sebum excretion rate and increased transepidermal water loss (TEWL) values than normal healthy subjects. But no significant difference of specific Malassezia yeasts species between hyperpigmented and hypopigmented skin lesions was evident. These results indicate that higher humidity and increased sebum level provide a better growing environment of Malassezia yeasts in the skin, leading to the assumption that interaction between Malassezia yeasts and skin barrier materials makes disruption of skin barrier causing increased TEWL.

  7. Comparative study of effectiveness of oral acyclovir with oral erythromycin in the treatment of Pityriasis rosea.

    Science.gov (United States)

    Amatya, A; Rajouria, E A; Karn, D K

    2012-01-01

    Pityriasis rosea is an acute, self-limiting disease, probably infective in origin, affecting mainly children and young adults, characterized by distinctive skin eruptions and minimal constitutional symptoms. Both oral Erythromycin and oral Acyclovir have been used in its management. To compare the effectiveness of oral Erythromycin and oral Acyclovir in the treatment of Pityriasis rosea. Forty two patients with clinical diagnosis of Pityriasis rosea were enrolled. They were randomized into two groups. One group was given high-dose oral Acyclovir and another group oral Erythromycin in standard dose. The participants were evaluated one, two, four, six and eight weeks and six months after commencement of the study. Forty two patients including 26 males and 16 females completed the study. After 8th week, all patients showed complete response in both the groups. The response to oral Acyclovir compared with that to oral Erythromycin was better and was statistically significant in 1st, 2nd, 4th and 6th weeks. Although it is a self-limiting disease which resolves within three weeks to three months, this study reveals that both oral Acyclovir and oral Erythromycin are helpful in decreasing the severity and duration of Pityriasis rosea. Moreover, the study also indicates that oral Acyclovir is more effective than oral Erythromycin in reducing the severity and duration of Pityriasis rosea.

  8. Pityriasis versicolor: A clinicomycological and epidemiological study from a tertiary care hospital

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    Ghosh Sudip

    2008-01-01

    Full Text Available Background: Pityriasis versicolor is a mild, chronic, usually asymptomatic superficial fungal infection of the stratum corneum, caused by Malassezia yeasts. The purpose of the present study is to assess the clinical profile of a group of patients with pityriasis versicolor and to find out the epidemiological characteristics in this part of India as well as any association, if any, with other diseases. Materials and Methods: For this purpose, 110 consecutive patients of pityriasis versicolor were evaluated clinically and diagnosis was confirmed mycologically at a tertiary care hospital in Kolkata. All data were recorded in a predesigned, pretested semi-structured schedule. The total duration of study period was 12 months. Results: Majority of the patients were young adults. Most of the patients were asymptomatic. There is prominent seasonal variation of the patients with a peak in August and September months. Most of the lesions were hypopigmented scaly macules and were KOH positive. Most commonly involved sites were chest, face and back. Seborrheic dermatitis sometimes coexisted with pityriasis versicolor and a number of patients also had diabetes mellitus and immunosuppressive conditions. Conclusions: Overall, the clinicomycological and epidemiological profile of pityriasis versicolor infection as observed in a tertiary care setting in eastern India does not differ significantly from those observed by previous workers elsewhere.

  9. Isolation of Malassezia globosa and M. sympodialis from patients with pityriasis versicolor in Spain.

    Science.gov (United States)

    Aspiroz, Carmen; Ara, Mariano; Varea, Marzo; Rezusta, Antonio; Rubio, Carmen

    2002-01-01

    Pityriasis versicolor is a superficial infection of the stratum corneum by several yeast species formerly collectively named Malasseziafurfur. The genus Malassezia has been recently enlarged with new species. With the exception of M. pachydermatis, the remaining six species have an absolute requirement in vitro for supplementation of long-chain fatty acids in media. These lipophilic yeasts comprise six species: M. furfur, M. globosa, M. obtusa, M. restricta, M. slooffiae and M. sympodialis. The aim of this study was to establish whether there was any association between the various species of Malassezia and pityriasis versicolor lesions. Thus, we studied the isolates from 79 patients with pityriasis versicolor, both from lesions and from apparently healthy skin close to the visible lesions. In pityriasis versicolor lesions, the species most frequently isolated was M. globosa (90%), followed by M. sympodialis (41%). Almost all isolates (99%) belonged to one of these two species. The most frequent pattern was M. globosa as the sole species (58% of cases), although the association with M. sympodialis was also frequent (30%). These results confirmed M. globosa as the main agent of pityriasis versicolor and M. sympodialis as the second agent in importance. Malassezia globosa was found to be a species with high levels of esterase and lipase enzymes of probable importance in their pathogenicity.

  10. Atrophic pityriasis versicolor occurring in a patient with Sjögren's syndrome.

    Science.gov (United States)

    Marinello, Elena; Piaserico, Stefano; Alaibac, Mauro

    2017-01-18

    Pityriasis versicolor is one of the most frequent epidermal mycotic infections in the world, but its atrophic variant is rarely described. The aetiology of the atrophy is still unknown, and two main hypotheses have been formulated, one suggesting a correlation with long-term use of topical steroids and the other a delayed type hypersensitivity to epicutaneous antigens derived from components of the fungus. Atrophic pityriasis versicolor is a benign disease, but needs to be distinguished from other more severe skin diseases manifesting with cutaneous atrophy. The diagnosis can be easily confirmed by direct microscopic observation of the scales soaked in 15% potassium hydroxide, which reveals the typical 'spaghetti and meatball' appearance, or by a skin biopsy in doubtful cases. Here, we describe a case of extensive atrophic pityriasis versicolor occurring in a woman affected by Sjögren's syndrome which completely resolved after topical antifungal treatment. 2017 BMJ Publishing Group Ltd.

  11. Molecular identification and prevalence of malassezia species in pityriasis versicolor patients from kashan, iran.

    Science.gov (United States)

    Talaee, Rezvan; Katiraee, Farzad; Ghaderi, Maryam; Erami, Mahzad; Kazemi Alavi, Azam; Nazeri, Mehdi

    2014-08-01

    Malassezia species are lipophilic yeasts found on the skin surface of humans and other warm-blooded vertebrates. It is associated with various human diseases, especially pityriasis versicolor, which is a chronic superficial skin disorder. The aim of the present study was to identify Malassezia species isolated from patients' samples affected by pityriasis versicolor, using molecular methods in Kashan, Iran. A total of 140 subjects, suspected of having pityriasis versicolor from Kashan, were clinically diagnosed and then confirmed by direct microscopic examination. The scraped skin specimens were inoculated in modified Dixon's medium. DNA was extracted from the colonies and PCR amplification was carried out for the 26s rDNA region. PCR products were used to further restriction fragment length polymorphism by CfoI enzyme. Direct examination was positive in 93.3% of suspected pityriasis versicolor lesions. No statistically significant difference was observed in the frequency of Malassezia species between women and men. The highest prevalence of tinea versicolor was seen in patients 21-30 years-of-age. No difference could be seen in the frequency of Malassezia species depending on the age of the patients. In total, 65% of patients with pityriasis versicolor had hyperhidrosis. The most commonly isolated Malassezia species in the pityriasis versicolor lesions were; Malassezia globosa (66%), M. furfur (26%), M. restricta (3%), M. sympodialis (3%), and M. slooffiae (2%). Malassezia species were mainly isolated from the neck and chest. This study showed M. globosa to be the most common Malassezia species isolated from Malassezia skin disorders in Kashan, Iran. The PCR-RFLP method was useful in the rapid identification of the Malassezia species. By using these methods, the detection and identification of individual Malassezia species from clinical samples was substantially easier.

  12. Drug-related pityriasis rubra pilaris with acantholysis.

    Science.gov (United States)

    Gajinov, Zorica T; Matić, Milan B; Duran, Verica D; Vucković, Nada; Prcić, Sonja T; Vujanović, Ljuba M

    2013-09-01

    Acantholysis is rarely reported histological feature of Pityriasis rubra pilaris (PRP), recently recognized as having diagnostic specificity for differentiating PRP from psoriasis. Adult male patient one week after the introduction of simvastatin had experienced pruritic erythemo-squamous eruption on head and upper trunk that in a month progressed to erythrodermia, with islands of sparing. Histological picture combined pemphigus-like acantholysis with alternating hyper- and parakeratosis, follicular plugs and dermal inflammation, and confirmed the clinical diagnosis of classic adult type 1 PRP. Acitretin therapy resulted in a resolution of skin disease. Patch test with simvastatin was negative, scratch test was positive, and it was estimated that potential risk of oral challenge with simvastatin outweighed actual need for it. Drug triggering PRP episode is the most likely explanation for temporal relation between the start of simvastatin treatment and skin eruption. In management of rare inflammatory skin disease, such as PRP, we have to carefully observe and evaluate not only diagnostic features but possible external influences on its course also.

  13. Drug-related pityriasis rubra pilaris with acantholysis

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    Gajinov Zorica T.

    2013-01-01

    Full Text Available Introduction. Acantholysis is rarely reported histological feature of Pityriasis rubra pilaris (PRP, recently recognized as having diagnostic specificity for differentiating PRP from psoriasis. Case report. Adult male patient one week after the introduction of simvastatin had experienced pruritic erythemo-squamous eruption on head and upper trunk that in a month progressed to erythrodermia, with islands of sparing. Histological picture combined pemphigus-like acantholysis with alternating hyper- and parakeratosis, follicular plugs and dermal inflammation, and confirmed the clinical diagnosis of classic adult type 1 PRP. Acitretin therapy resulted in a resolution of skin disease. Patch test with simvastatin was negative, scratch test was positive, and it was estimated that potential risk of oral challenge with simvastatin outweighed actual need for it. Drug triggering PRP episode is the most likely explanation for temporal relation between the start of simvastatin treatment and skin eruption. Conclusion. In management of rare inflammatory skin disease, such as PRP, we have to carefully observe and evaluate not only diagnostic features but possible external influences on its course also.

  14. The Oxidant and Antioxidant Status in Pityriasis Rosea

    Science.gov (United States)

    Emre, Selma; Akoglu, Gulsen; Metin, Ahmet; Demirseren, Duriye Deniz; Isikoglu, Semra; Oztekin, Aynure; Erel, Ozcan

    2016-01-01

    Background: Pityriasis rosea (PR) is usually an asymptomatic and self-limiting papulosquamous skin disease with acute onset. The etiology has not been clarified yet. Recently, increased oxidative stress was found to play a role in etiopathogenesis of multiple cutaneous diseases with T cell-mediated immune response. However, there are no studies demonstrating the oxidative stress status in PR. Aim: The aim of the study is to determine the status of oxidative stress (OS) and paraoxonase (PON) 1/arylesterase enzyme activities in PR. Materials and Methods: Study included 51 patients with active PR lesions, and 45 healthy volunteers. Serum levels of total oxidant status (TOS), total antioxidant status (TAS), and PON1/arylesterase (ARES) activity were determined and oxidative stress index (OSI) was calculated in all patients and controls. Results: TAS levels and ARES activities in the patient group were significantly lower than the control group. On the other hand, TOS and OSI levels were significantly higher in patients compared with controls. There was no significant correlation between the duration of disease and TAS, TOS, OSI levels, and ARES activities. Conclusion: A systemic oxidative stress exists in PR, which suggests that OS may be involved in the etiopathogenesis of disease. PMID:26955119

  15. The oxidant and antioxidant status in pityriasis rosea

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    Selma Emre

    2016-01-01

    Full Text Available Background: Pityriasis rosea (PR is usually an asymptomatic and self-limiting papulosquamous skin disease with acute onset. The etiology has not been clarified yet. Recently, increased oxidative stress was found to play a role in etiopathogenesis of multiple cutaneous diseases with T cell-mediated immune response. However, there are no studies demonstrating the oxidative stress status in PR. Aim: The aim of the study is to determine the status of oxidative stress (OS and paraoxonase (PON 1/arylesterase enzyme activities in PR. Materials and Methods: Study included 51 patients with active PR lesions, and 45 healthy volunteers. Serum levels of total oxidant status (TOS, total antioxidant status (TAS, and PON1/arylesterase (ARES activity were determined and oxidative stress index (OSI was calculated in all patients and controls. Results: TAS levels and ARES activities in the patient group were significantly lower than the control group. On the other hand, TOS and OSI levels were significantly higher in patients compared with controls. There was no significant correlation between the duration of disease and TAS, TOS, OSI levels, and ARES activities. Conclusion: A systemic oxidative stress exists in PR, which suggests that OS may be involved in the etiopathogenesis of disease.

  16. Differentiation of pityriasis rubra pilaris from plaque psoriasis by dermoscopy.

    Science.gov (United States)

    Abdel-Azim, N E; Ismail, S A; Fathy, E

    2017-05-01

    Pityriasis rubra pilaris (PRP) and plaque psoriasis (PP) are two distinctive erythemato-squamous skin diseases that often have to be differentiated from each other and from other similar dermatoses. Dermoscopy has been proven to aid the clinical diagnosis of several inflammatory disorders, minimizing the need for skin biopsy. Our aim was to determine the dermoscopic patterns of PRP compared to PP and to assess the significance of certain dermoscopic criteria in the diagnosis of PRP. This case-control study included 11 patients with biopsy proven PRP and 25 patients with biopsy proven plaque psoriasis. The most recently developed lesion of each patient was examined by non-contact dermoscopy. Whitish keratotic plugs and linear vessels in yellowish background are significant dermoscopic features of PRP compared to white diffuse scales and dotted vessels in a light red background in PP. In conclusion, PRP and PP reveal specific distinguishing dermoscopic patterns that may assist in their clinical diagnosis and may also be useful for the differential diagnosis from other resembling dermatoses.

  17. Pitiríase rósea Pityriasis rosea

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    Sandra Maria Bitencourt Miranda

    2008-10-01

    Full Text Available Pitiríase rósea é doença inflamatória aguda da pele, que regride espontaneamente, normalmente sem deixar seqüelas, em período que varia de quatro a oito semanas. Clinicamente é caracterizada pelo aparecimento de típicas lesões eritêmato-pápulo-escamosas. Atinge todas as idades, embora seja mais comumente observada entre 10 e 35 anos. Apesar de exaustivas pesquisas, sua etiologia ainda permanece desconhecida. São discutidos alguns aspectos epidemiológicos, anatomoclínicos, diagnósticos diferenciais, doenças associadas, com ênfase no tratamento e etiologia da doença.Pityriasis rosea is a skin disease characterized by acute inflammation that fades away spontaneously without scar tissue formation for an average period of 4 to 8 weeks. Clinically, it is characterized by the occurrence of typical erythematous papulosquamous lesions distributed mainly over the trunk and extremities. It affects people of all ages, but is more often observed in the age range of 10 to 35 years. Even though it is extensively studied, its etiology remains unknown. In this study, the authors analyze some epidemiologic aspects, differential diagnosis, related diseases, and give special attention to treatment and possible etiology.

  18. An unusual cluster of circumscribed juvenile pityriasis rubra pilaris cases.

    Science.gov (United States)

    Martin, Kari L; Holland, Kristen E; Lyon, Valerie; Chiu, Yvonne E

    2014-01-01

    Circumscribed juvenile pityriasis rubra pilaris (PRP) is an uncommon dermatosis. We describe the unusual clustering of circumscribed juvenile PRP cases in our pediatric dermatology clinic in 2011. A retrospective chart review was done of patients presenting during the summer of 2011 with classic findings of circumscribed juvenile PRP. Clinical data including past medical and family history, presenting symptoms, infectious disease history and evaluation, biopsy results, and management were recorded. Seven patients, ages 5 to 19 years, all had strikingly similar skin findings of pink to hyperpigmented, well-defined, scaly papules and plaques on their elbows, knees, dorsal hands, ankles, and Achilles tendons. Four of the seven also had palmoplantar involvement. Four were sibling pairs and the other three were unrelated. Streptococcus pyogenes infection was suspected as a trigger in four of the patients. The unusual clustering of this uncommon disease, along with the occurrence in two sibling pairs, suggests that a genetic susceptibility unmasked by an infectious agent may play a role in its pathogenesis. © 2014 Wiley Periodicals, Inc.

  19. [Pityriasis versicolor : new aspects of an old disease].

    Science.gov (United States)

    Mayser, P A; Preuss, J

    2012-11-01

    Pityriasis versicolor (PV) is one of the most common infectious skin diseases, as well as the most common dermatosis associated with pigmentation alterations of the skin. PV is prevalent in 1% of the population living in temperate climate zones and more common during the summer. In tropical areas, PV is found in up to 50% of all patients consulting a dermatologist. Of the known Malassezia species, M. globosa is currently felt to play a key role in the pathogenesis of PV, as it is most commonly found in PV lesions. In addition, its round-shaped cells may contribute to the characteristic histology of the disease ("spaghetti and meatballs"). However, the clinical appearance of PV including hyper- and hypopigmentation, fluorescence of the lesions, as well as a lack of inflammation despite high fungal load cannot fully be explained by the presence of M. globosa, which is also found on healthy skin. In M. furfur a tryptophan-dependent metabolic pathway generates a number of indole pigments, which may be associated with the clinical appearance of PV. In the model organism Ustilago maydis it was shown that the formation of the indole compounds occurs spontaneously after initial conversion of tryptophan into indole pyruvate controlled by the key enzyme aminotransferase Tam 1. We review the present knowledge of PV and highlight the potential role of Tam1 in explaining the poorly understood aspects of the disease. Promising therapeutic results using the application of Tam1 inhibitors to treat PV support the enzyme's important role in the disease pathogenesis.

  20. A child with PFAPA syndrome complicated by pityriasis lichenoides et varioliformis acuta.

    Science.gov (United States)

    Iba, Yoshinori; Sugimoto, Keisuke; Sakata, Naoki; Kawada, Akira; Takemura, Tsukasa

    2011-01-01

    We encountered a boy with periodic fever, aphthous-stomatitis, pharyngitis, adenitis syndrome, complicated by a papular rash representing pityriasis lichenoides et varioliformis acuta. Proinflammatory cytokines have been implicated in both diseases and may represent the underlying common immunologic mechanism causing the two diseases. © 2011 Wiley Periodicals, Inc.

  1. Hypopigmented pityriasis versicolor on Becker′s naevus : Hope for new method of treatment ?

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    Singal Archana

    1998-01-01

    Full Text Available A case of hypopigmented pityriasis versicolor superimposed on pre existing Becker′s naevus associated with congenital melanocytic naevus is being reported for its rarity. The possible role of dicarboxylic acid and other free radicles produced by Pityrosporum ovale in treating Becker′s Naevus is also suggested.

  2. Pityriasis Rotunda: A Case Report of Familial Disease in an American-Born Black Patient

    Science.gov (United States)

    Lefkowitz, Emily G.; Natow, Allen J.

    2016-01-01

    Pityriasis rotunda is an uncommon dermatosis with an unusual geographic and racial distribution. The skin disorder is characterized by sharply defined, perfectly circular, scaly patches with no inflammatory changes. Notably, it may be associated with underlying malignancy or chronic infection. We report an uncommon familial case in an American-born female. PMID:27065844

  3. A Herald Patch Almost Encircling the Trunk-Extreme Pityriasis Rosea Gigantea in a Young Child.

    Science.gov (United States)

    Chuh, Antonio

    2016-09-01

    An 18-month-old girl presented with pityriasis rosea gigantea. The herald patch encircled almost the entire trunk. The distribution of lesions on the trunk and proximal aspects of the limbs, the collarette scaling, the orientation of some lesions along the skin crease lines, and biopsy findings substantiated the diagnosis. © 2016 Wiley Periodicals, Inc.

  4. SIXTEEN YEARS OF PITYRIASIS VERSICOLOR IN METROPOLITAN AREA OF PORTO ALEGRE, SOUTHERN BRAZIL.

    Science.gov (United States)

    Heidrich, Daiane; Daboit, Tatiane Caroline; Stopiglia, Cheila Denise Ottonelli; Magagnin, Cibele Massotti; Vetoratto, Gerson; Amaro, Taís Guarienti; Scroferneker, Maria Lúcia

    2015-01-01

    Pityriasis versicolor is the most common of the diseases caused by Malassezia yeasts. The aim of this study is to determine the prevalence of pityriasis versicolor and its etiological aspects in the metropolitan area of Porto Alegre, Brazil. A retrospective cross-sectional study with data from patients of a reference hospital from 1996 to 2011 was performed. Collected data included: date, age, gender, ethnicity, anatomical region of lesion and the direct mycological examination results. Among the positive results in the direct mycological examination, 5.8% (2,239) were positive for pityriasis versicolor. The angular coefficient (B) was -0.3%/year, showing a decrease over the years. The disease was more prevalent in men (7.1% of men versus 5.1% of women that underwent the direct mycological examination); younger age (median 31 years old); "pardo" and black people (3.7% more than expected in the sample); trunk (73.44% of the affected anatomic sites). Lesions in rare sites (groin, genitals, legs, feet and hands) were also observed in this study. In conclusion, due to the decrease in the prevalence of pityriasis versicolor, long-term epidemiological studies in the metropolitan area of Porto Alegre, Brazil, are needed to continue the monitoring of this disease.

  5. Pityriasis versicolor: clinical experience with Lamisil cream and Lamisil DermGel.

    Science.gov (United States)

    Faergemann, J; Hersle, K; Nordin, P

    1997-01-01

    Pityriasis versicolor is a chronic superficial fungal disease usually located on the upper trunk, neck or upper arms. Terbinafine is an orally and topically active allylamine antifungal derivative with a broad antifungal spectrum. Several studies have documented the high activity of terbinafine (Lamisil) cream in the treatment of pityriasis versicolor, with cure rates of 79-100% after 2-4 weeks of treatment. Lamisil emulsion gel (Lamisil DermGel) is a new topical formulation that remains in the skin in high concentrations for several months after just 1 week of application. Recently, in a prospective, double-blind, placebo-controlled, randomised, parallel-group, comparative, multicentre study, we have treated patients with pityriasis versicolor with either terbinafine 1% emulsion gel (Lamisil DermGel) or placebo gel. Sixty-one patients were included, 31 in the Lamisil DermGel group and 30 in the placebo gel group. The gel was applied once daily for 7 days and the patients were followed up for 8 weeks. Twenty-eight patients in the active and 29 patients in the placebo group were evaluable for efficacy. Using the intent-to-treat efficacy analysis, 21/28 (75%) were cured in the Lamisil-DermGel-treated group compared to 4/29 (14%) in the placebo group. No side-effects were seen. In conclusion, Lamisil DermGel was well tolerated and superior to placebo in the treatment of pityriasis versicolor when applied once daily for 7 days.

  6. Pityriasis Rotunda: A Case Report of Familial Disease in an American-Born Black Patient

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    Emily G. Lefkowitz

    2016-03-01

    Full Text Available Pityriasis rotunda is an uncommon dermatosis with an unusual geographic and racial distribution. The skin disorder is characterized by sharply defined, perfectly circular, scaly patches with no inflammatory changes. Notably, it may be associated with underlying malignancy or chronic infection. We report an uncommon familial case in an American-born female.

  7. Prevalence of Malassezia species in patients with pityriasis versicolor in Rosario, Argentina

    OpenAIRE

    2011-01-01

    Background Malassezia species are considered opportunistic yeasts of increasing clinical importance. These lipophilic yeasts are associated with various human diseases, especially pityriasis versicolor (PV), a chronic superficial scaling dermatomycosis. Aims The aim of this study was to isolate, identify and analyze the distribution of the different species of Malassezia in patients with PV in Rosario city (Argentina). Methods A total of 264...

  8. Identification and speciation of Malassezia in patients clinically suspected of having pityriasis versicolor

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    Avani Shah

    2013-01-01

    Full Text Available Background: Malassezia is a lipid-dependent yeast known to cause Pityriasis versicolor, a chronic, recurrent superficial infection of skin and present as hypopigmented or hyperpigmented lesions on areas of skin. If not diagnosed and treated, it may lead to disfigurement of the areas involved and also result in deep invasive infections. Aim: The aim of the present study was to identify and speciate Malassezia in patients clinically suspected of having Pityriasis versicolor. Materials and Methods: Total 139 patients suspected of having Pityriasis versicolor were evaluated clinically and diagnosis was done by Wood′s lamp examination, confirmed mycologically by using KOH, cultivation on Sabouraud′s dextrose agar and modified Dixon agar at a tertiary care hospital in Mumbai. The total duration of study was 12 months. Results: Majority of the patients were males (59.71% in the age group of 21-30 years (33.81% who were students (30.21% by profession. The incidence of Malassezia in Pityriasis versicolor was 50.35%. The most common isolate was M. globosa (48.57%, followed by M. furfur (34.28%. Majority of the patients had hypopigmented lesions, with M. globosa as the predominant isolate. Neck was the most common site affected; 88.48% were Wood′s lamp positive of which 56.91% of Malassezia isolates grew on culture. KOH mount was positive in 82.01% of which 61.40% Malassezia isolates grew on culture. Conclusions: The procedure of culture and antifungal testing is required to be performed as different species of Malassezia are involved in Pityriasis versicolor and susceptibility is different among different species. Thus, it would help to prevent recurrences and any systemic complications.

  9. DISTRIBUTION OF MALASSEZIA SPECIES IN PATIENTS WITH PITYRIASIS VERSICOLOR AND HEALTHY INDIVIDUALS IN SOUTH INDIA

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    Kavitha

    2016-04-01

    Full Text Available BACKGROUND Pityriasis Versicolor is a superficial infection of the stratum corneum which is caused by a group of yeasts called Malassezia. OBJECTIVES To isolate and identify the causative fungi from clinically suspected cases of Pityriasis Versicolor by 10% KOH and to compare the results of 10% KOH with culture. METHODS 100 clinically diagnosed cases of Pityriasis Versicolor of all age groups and both sexes, attending the Outpatient Department of Dermatology at Bapuji Hospital and Chitageri Hospital were included in this study. Skin scrapings from lesions of all cases were subjected to 10% KOH examination and culture. A control group of 50 healthy individuals was studied to know the normal fungal flora of the skin. Differentiation of all Malassezia species performed using morphological features and physiological tests including catalase reaction, Tween assimilation test and splitting of esculin. RESULTS Out of 100 clinically diagnosed Pityriasis Versicolor cases, 97(97% cases showed characteristic arrangement of fungal elements in 10% KOH preparation and culture was positive in 68 cases. The most frequently isolated species was M. globosa (54.41%, followed by M. furfur (25%, M. sympodialis (11.76% and M. obtusa (8.82%. In control group, M. globosa was the common isolate. CONCLUSION In comparison with culture results, the sensitivity and specificity of 10% KOH is 100% and 9.37% respectively. It does not require highly skilled personnel to perform or interpret results. The only disadvantage of KOH examination is that the Malassezia species cannot be differentiated. Culture is the gold standard, but it is time consuming and requires considerable expertise. Therefore, 10% KOH examination is a rapid, simple, sensitive and effective diagnostic test for Pityriasis Versicolor. M. globosa was the most common isolated species followed by M. furfur, M. sympodialis and M. obtusa

  10. Distribution of Malassezia species in patients with pityriasis versicolor in Turkey.

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    Rodoplu, G; Saracli, M A; Gümral, R; Taner Yildiran, S

    2014-06-01

    Pityriasis versicolor is a common superficial mycotic disease of the skin which is caused by different species of Malassezia genus. The aim of this study was to contribute to the knowledge of the aetiology of pityriasis versicolor (PV) with a mycological study made according to the new species and additionally, the success of the different sampling techniques, duration and recurrence history of the disease, distribution of infecting strains according to the affected body sites were also investigated. In total, 146 patients with pityriasis versicolor were included in this study. Fungal elements could only be visualized by potassium hydroxide examination in 36.4% of the samples. Specimens obtained by scraping skin surface by a sterile scalpel and/or sterile sticky plaster (OpSite) were inoculated in plates containing modified Dixon's medium. Out of 146 samples, 109 (74.7%) yielded a growth which was considered to be Malassezia spp. in culture. Species level identification of suspicious Malassezia yeasts was made according to their macroscopic and microscopic features, and their physiological characteristics. Among the identified species, Malassezia globosa (65.1%) was the most commonly isolated species, followed by Malassezia obtusa (17.4%). However, four Malassezia isolates could not be identified at species level with conventional methods. While most of the patients suffered their first episode of pityriasis versicolor (76%), back of the trunk was the mostly affected body site (39%). In conclusion, Malassezia globosa was found to be the predominant species in pityriasis versicolor patients in our region, and culture of the specimen is necessary for the epidemiologic purposes. Copyright © 2014. Published by Elsevier Masson SAS.

  11. Identification and speciation of malassezia in patients clinically suspected of having pityriasis versicolor.

    Science.gov (United States)

    Shah, Avani; Koticha, Avani; Ubale, Milind; Wanjare, Shashir; Mehta, Preeti; Khopkar, Uday

    2013-05-01

    Malassezia is a lipid-dependent yeast known to cause Pityriasis versicolor, a chronic, recurrent superficial infection of skin and present as hypopigmented or hyperpigmented lesions on areas of skin. If not diagnosed and treated, it may lead to disfigurement of the areas involved and also result in deep invasive infections. The aim of the present study was to identify and speciate Malassezia in patients clinically suspected of having Pityriasis versicolor. Total 139 patients suspected of having Pityriasis versicolor were evaluated clinically and diagnosis was done by Wood's lamp examination, confirmed mycologically by using KOH, cultivation on Sabouraud's dextrose agar and modified Dixon agar at a tertiary care hospital in Mumbai. The total duration of study was 12 months. Majority of the patients were males (59.71%) in the age group of 21-30 years (33.81%) who were students (30.21%) by profession. The incidence of Malassezia in Pityriasis versicolor was 50.35%. The most common isolate was M. globosa (48.57%), followed by M. furfur (34.28%). Majority of the patients had hypopigmented lesions, with M. globosa as the predominant isolate. Neck was the most common site affected; 88.48% were Wood's lamp positive of which 56.91% of Malassezia isolates grew on culture. KOH mount was positive in 82.01% of which 61.40% Malassezia isolates grew on culture. The procedure of culture and antifungal testing is required to be performed as different species of Malassezia are involved in Pityriasis versicolor and susceptibility is different among different species. Thus, it would help to prevent recurrences and any systemic complications.

  12. Pityriasis rubra pilaris: a review of diagnosis and treatment.

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    Klein, Annette; Landthaler, Michael; Karrer, Sigrid

    2010-01-01

    Pityriasis rubra pilaris (PRP) is a rare inflammatory dermatosis of unknown etiology, and finding a successful therapy can be challenging. PRP occurs equally in men and women. In some patients, associated autoimmune diseases, infections, or malignancies are possible trigger factors. PRP shows a bimodal age distribution, peaking in the first as well as in the fifth to sixth decade. Its classification into five subgroups is based on age at onset, clinical course, morphologic features, and prognosis. More than 50% of patients are best classified as type I with adult-onset PRP. This form is also characterized by high spontaneous remission rates (80%) within 1-3 years. Clinically, the classical adult (type I) and classical juvenile (type III) forms appear to be the same except for the patient's age. Recently, the designation of a new category of PRP (type VI) has been proposed that is characterized by the presence of HIV infection with different clinical features and a poorer prognosis. Typical morphologic features of PRP are erythematosquamous salmon-colored plaques with well demarcated islands of unaffected skin. Often, keratoderma of the palms and soles is present. In patients with extensive disease, ectropion is a dreaded complication. Histology shows hyperkeratosis, alternating orthokeratosis and parakeratosis in a checkerboard pattern, and focal acantholytic dyskeratosis. Descriptions and therapeutic experiences are mainly based on case reports. Mostly, systemic retinoids, methotrexate, and other immunosuppressive agents as well as UV light therapy are applied, with varying response rates. In recent years, treatment with so-called 'biologics' is becoming more and more popular for treating recalcitrant PRP. We present a review of the clinical features, histopathologic findings, classification, differential diagnoses, and treatment of PRP.

  13. Demographical and Clinical Characteristics of Patients with Pityriasis Rosea in 1 Year in A Tertiary Care Hospital

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    Seval Karasatı

    2015-03-01

    Full Text Available Objective: Pityriasis rosea is a disease still taking interest with its unknown etiology, different clinical aspects and diagnosis and treatment alternatives. The clinical and demographical characteristics of the patients with pityriasis rosea were investigated in this study. Methods: A total of 70 patients, who were diagnosed as pityriasis rosea, between June 2011 and June 2012 were evaluated. The patients were examined prospectively in terms of their demographical characteristics, related environmental and personal factors, clinical characteristics and course of the disease. Results: The mean age of 70 patients (41 females, 29 males was 25.9±15.26 (2-69 years. Seasons in which the disease is seen most frequently were winter (37.1% and autumn (27.2%. The most common symptom was fatigue (64.3% in patients who had prodromal symptoms (n=28. Primary plaque was determined in 44 cases (58.6% and the most frequent localization was neck (22.7%. The most frequent symptom was pruritus and it was present in 41 patients. Eleven patients were diagnosed as atypical pityriasis rosea. One patient demonstrated unusual presentation of pityriasis rosea with localization to neck, and another one with secondary lesions on external ear tunnel which has not been described previously. Pityriasis rosea frequency in dermatology outpatients was 1/1000. Conclusion: The demographical results of this study were consistent with the results of the previously reported studies in Turkey.

  14. Pityriasis Rosea: A rash that should be recognized by the primary care physician. Study of 30 cases

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    Igor López-Carrera

    2014-08-01

    Full Text Available Background: Pityriasis rosea is an acute disseminated rash of unknown etiology and prolonged duration, characterized by erythematous- squamous plaques. Despite having an ostentatious clinical picture for both the patient and family, it is self-limited and usually resolves without sequelae. Pityriasis rosea is often erroneously diagnosed as mycosis and given unnecessary treatment. Objective: To describe the clinical and demographical features of pity- riasis rosea in a group of Mexican pediatric patients. Patients and methods: Retrospective and descriptive study in which the clinical and demographic features of patients attended at the department of dermatology of the National Institute of Pediatrics with diagnosis of pityriasis rosea within a ten year period were analysed. Results: Thirty patients with pityriasis rosea, with a frequency of 3.6 per 1000 dermatological patients. Pityriasis rosea was more frequent in females with a ratio of 1.5 to 1 and a mean age of 10 years. More than half of the patients (56% had an atypical presentation, and biopsy was mandatory in 7 patients to establish the final diagnosis. Conclusions: The knowledge of the clinical features of pityriasis rosea by primary care physicians will prevent from unnecessary work-up and treatments.

  15. Segmental lesions in pityriasis rosea: a rare presentation.

    Science.gov (United States)

    Zawar, Vijay; Godse, Kiran

    2011-01-01

    potassium hydroxide smear examination. The patient declined skin biopsy; however, we thought that the most diagnostic label for this condition was pityriasis rosea. Hence, we treated her with triamcinolone acetonide ointment 0.025% to be applied twice daily and desloratadine tablet 5 mg daily for 10 days. The patient demonstrated complete resolution, leaving postinflammatory hypopigmentation. There was no recurrence until 1 year after complete remission.

  16. Clinico-epidemiological study of pityriasis versicolor in a rural tertiary care hospital

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    Nazeema Tabaseera

    2014-08-01

    Full Text Available Background: The study was conducted to know the incidence of pityriasis versicolor in relation to age, sex, seasons and occupation in a rural set up. Methods: A total of 105 patients of pityriasis versicolor were clinically evaluated and confirmed mycologically at central lab in a tertiary care hospital in South India. The obtained data was recorded and analysed accordingly. Results: Male preponderance was observed in the study. Disease was most pronounced in younger age group (21-30 years especially students. 61.9% of patients sought medical advice on cosmetic grounds while 38% had pruritis. Chest was the commonest site of affection followed by neck and back. Conclusion: Early identification of the yeast by simple laboratory techniques would help prevent recurrences, systemic complications and cosmetological problems which are high especially among the students and younger age groups. [Int J Res Med Sci 2014; 2(4.000: 1438-1440

  17. Comparative study of oral and topical ketoconazole therapy in pityriasis versicolor

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    Nagpal V

    2003-07-01

    Full Text Available Introduction: Both topical and systemic ketoconazole are reported to be effective against pityriasis versicolor. Material and Methods: Forty patients suffering from pityriasis versicolor were treated either with oral ketoconazole 200 mg per day or 2% ketoconazole cream topically once daily for 2 weeks. Results: On global assessment, after 2 weeks of start of therapy, 18 (90% out of 20 patients treated with oral ketoconazole were cured while 2 patients had considerable residual disease. In the ketoconazole cream group, 16 (80% out of 20 patients were cured and 4 patients had considerable residual disease. Conclusion: No significant difference was observed in the response rates in the two groups. Relapse occurred in two patients of the systemic ketoconazole group and six patients of the topical ketoconazole group during the follow-up period of three months.

  18. Long-term ustekinumab treatment for refractory type I pityriasis rubra pilaris.

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    Di Stefani, Alessandro; Galluzzo, Marco; Talamonti, Marina; Chiricozzi, Andrea; Costanzo, Antonio; Chimenti, Sergio

    2013-03-30

    Pityriasis rubra pilaris is a rare, chronic erythematous squamous disorder of unknown etiology. The disease is characterized initially by small follicular papules that coalesce into yellowish pink scaly plaques, palmoplantar keratoderma, diffuse furfuraceous scale of the scalp, and frequent progression to exfoliative erythroderma. Generally it is difficult to discern pityriasis rubra pilaris from other skin conditions but key-clinical features help in the diagnosis such as "islands" of spared skin within generalized erythroderma, follicular keratotic plugs, and an orange hue of the involved skin. Treatment options include topical vitamin D analogues, keratolytics, systemic acitretin, methotrexate, cyclosporine, azathioprine, fumaric acid esters, phototherapy, and anti-TNFα agents. Cases, of pityriasis rubra pilaris, successfully treated with a short-course ustekinumab therapy, have been reported. We report a 31-year-old man with pityriasis rubra pilaris, refractory to conventional treatments, successfully treated with ustekinumab monotherapy for over 64 weeks. After failing conventional systemic agents (cyclosporine, aciretin and methotrexate), ustekinumab 45 mg has been prescribed, with the same dosing regimen as in psoriasis. The patient improved dramatically within 4 weeks of the first injection, with markedly less erythema and pruritus. Long-term control of the disease of the disease was achieved (64 weeks of treatment). We report this case in order to show the striking and rapid efficacy of ustekinumab in reducing the signs and symptoms of the disease. Complete remission was achieved after the third injection, but also a long-term control of the disease. The therapy was well-tolerated in our patient and no adverse events occurred.

  19. Prevalence of different Malassezia species in pityriasis versicolor in central India

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    Chaudhary Rahul

    2010-01-01

    Full Text Available Background: In the last 10 years, different studies have shown interesting geographical variations in the prevalence of different Malassezia species in pityriasis versicolor. Aim: Identification of Malassezia species isolated from patients with pityriasis versicolor. Methods: In 100 patients with pityriasis versicolor, Malassezia species were identified by culture in Sabouraud′s dextrose agar containing cycloheximide with olive oil overlay and modified Dixon agar and by doing biochemical tests (catalase reaction, assimilation of glycine, and Tween utilisation tests. Results: In 10 patients, 10% KOH smear was negative, while in 90 patients the smear showed characteristic "spaghetti and meatball" appearance. Of these 90 cases, growth was obtained on modified Dixon′s agar in 87 cases. Fifty of the isolates (57.5% were M. globosa, 15 (17.2% were M. sympodialis, seven (8.0% were suspected M. sympodialis, 6 (6.9% each of the isolates were M. furfur and M. obtusa, and three (3.4% isolates were M. restricta. Conclusion: M. globosa was the most common species, followed by M. sympodialis, M. furfur, M. obtusa, and M. restricta.

  20. Pityriasis Lichenoides in Childhood: Review of Clinical Presentation and Treatment Options.

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    Geller, Lauren; Antonov, Nina K; Lauren, Christine T; Morel, Kimberly D; Garzon, Maria C

    2015-01-01

    Pityriasis lichenoides (PL) is a skin condition of unclear etiology that occurs not uncommonly in childhood. It is often classified into the acute form, pityriasis lichenoides et varioliformis acuta (PLEVA), and the chronic form, pityriasis lichenoides chronica (PLC). We performed a comprehensive review of the English-language literature using the PubMed database of all cases of childhood PL reported from 1962 to 2014 and summarized the epidemiology, clinical features, treatment options, and prognosis of this condition in children. The proposed etiologies are discussed, including its association with infectious agents, medications, and immunizations and evidence for PL as a lymphoproliferative disorder. We found an average age of PL onset of 6.5 years, with a slight (61%) male predominance. We also found that PLEVA and PLC tend to occur with equal frequency and that, in many cases, there is clinical and histopathologic overlap between the two phenotypes. When systemic therapy is indicated, we propose that oral erythromycin and narrowband ultraviolet B phototherapy should be first-line treatment options for children with PL since they have been shown to be effective and well tolerated. In most cases, PL follows a benign course with no greater risk of cutaneous T-cell lymphoma, although given the rare case reports of transformation, long-term follow-up of these patients is recommended. © 2015 Wiley Periodicals, Inc.

  1. Pityriasis lichenoides chronica: case reports – the role of infectious agents?

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    Anca Chiriac

    2014-06-01

    Full Text Available Introduction. pityriasis lichenoides chronica (PLC, which is a benign eruption with lymphocytic infiltrates of the skin, presents as a persistent, erythematous, papular eruption with scale. Patients may have guttate, hypopigmented macules with scale in addition to papules. It is related histopathologically to pityriasis lichenoides et varioliformis acuta (PLEVA, which presents as a recurrent papulonecrotic eruption. The PLC is a cutaneous disease of unknown etiology that most commonly affects children and young adults. The highly variable presentation of this condition often poses a diagnostic challenge. Objective. Presentation of two adults with PLC probably induced by infectious agents. Case reports. A woman presented with scaly, pruritic, erythematous-to-brown flattened papules, which varied in size from 3 mm to 1 cm, on the trunk and extremities, being first diagnosed as guttate psoriasis. A man sought medical advice for a disseminated eruption on the trunk and extremities, observed for 2 months before the consultation. He was in a good medical state, with no comorbidities and no medication. He complained of discrete pruritus and urethral discharge for many days. Conclusions. Pityriasis lichenoides may have arisen secondarily to these infections or there were two simultaneous diseases. Further studies must elucidate the role of infectious agents in this pathology.

  2. Late onset pityriasis rubra pilaris type IV treated with low-dose acitretin.

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    Mota, Fernando; Carvalho, Sandrina; Sanches, Madalena; Selores, Manuela

    2016-01-01

    Pityriasis rubra pilaris is a chronic inflammatory dermatosis of unknown etiology and great clinical variability. It has been divided into six categories. Types III, IV, and V occur in childhood and are distinguished by their clinical presentation, age of onset, and course. We report a 19-year-old male patient with a 2-week history of pruritic, scaling dermatosis of the hands, feet, elbows, and knees. He had no family history of skin disease. On physical examination, we observed circumscribed, reddish-orange, scaling plaques affecting the elbows and knees and a waxy palmoplantar keratoderma. The skin biopsy showed acanthosis, alternating orthokeratosis, parakeratosis, and follicular plugging suggestive of pityriasis rubra pilaris. The patient started treatment with oral acitretin, 25 mg every other day. The treatment was tolerated well, and after 6 months the lesions had resolved completely. Pityriasis rubra pilaris is a chronic papulosquamous disorder of unknown pathogenesis, characterized by reddish-orange scaly plaques, palmoplantar keratoderma, and keratotic follicular papules. There is still no consensus regarding the treatment, but therapeutic options include systemic retinoids, particularly acitretin in the recommended dose of 0.5 to 0.75 mg/kg/day. In our case, the patient was treated with a low-dose regimen of acitretin, which was effective and well tolerated.

  3. Malassezia yeast species isolated from Iranian patients with pityriasis versicolor in a prospective study.

    Science.gov (United States)

    Rasi, Abbas; Naderi, Reza; Behzadi, Ashkan Heshmatzade; Falahati, Mehraban; Farehyar, Shirin; Honarbakhsh, Yasamin; Akasheh, Amir Poya

    2010-07-01

    The goal of this study was to determine the prevalence of Malassezia species in pityriasis versicolor lesions and to examine if the range of species varies with patients characteristics such as: age, sex and family history and also clinical findings such as site and number of the lesions. In a prospective study from July 2006 to July 2007, the patients with a clinical diagnosis of pityriasis versicolor (n = 166) were asked to participate in the study. A total of 116 patients had positive culture for Malassezia species: M. globosa was found in 52 (31.3%) cases, M. furfur in 34 (20.5%) cases, M. pachydermatis in 12 (7.2%) cases, M. restricta in 12 (7.2%) cases, M. slooffiae in 6 (3.6%) cases. According to our data, M. globosa is the main species causing pityriasis versicolor, M. furfur was found to be the second-most frequent species. M. sympodialis and M. obtusa were not found in any case, and in 30.2% of patient's Malassezia culture was negative.

  4. Molecular epidemiology of Malassezia globosa and Malassezia restricta in Sudanese patients with pityriasis versicolor.

    Science.gov (United States)

    Saad, M; Sugita, T; Saeed, H; Ahmed, A

    2013-02-01

    Pityriasis versicolor is a superficial infection of the stratum corneum caused by Malassezia yeasts. The cutaneous Malassezia globosa and Malassezia restricta in Sudanese patients with pityriasis versicolor were elucidated using a molecular-based, culture-independent method and compared with that in healthy individuals. Scale samples were collected by applying an Opsite™ transparent dressing to lesional and non-lesional sites on 29 Sudanese patients with pityriasis versicolor and 54 healthy individuals. Malassezia DNA was extracted directly from the samples. The overall level of colonization by Malassezia globosa and Malassezia restricta was analyzed by real-time PCR using a TaqMan probe. The overall level of colonization by Malassezia at the lesional sites was higher than that at the non-lesional sites for all body sites, including the face, neck, cheeks, and trunk (2.7- to 6.0-fold increase). Both M. globosa and M. restricta were detected in patients and healthy individuals. However, M. globosa predominated at lesional sites, whereas the level of colonization by both species was similar in healthy individuals.

  5. Comparison between fluconazole and ketoconazole effectivity in the treatment of pityriasis versicolor.

    Science.gov (United States)

    Yazdanpanah, Mohammad Javad; Azizi, Hoda; Suizi, Behnaz

    2007-07-01

    Topical drugs are often effective in limited lesions of pityriasis versicolor; but in extensive cases, systemic drugs are more suitable. Previous studies have shown that ketoconazole and fluconazole are effective in 42-97% and 74-100% of lesions respectively. Our purpose was to compare the effectiveness of a single dose of 400 mg ketoconazole with two doses of 300 mg of fluconazole with 2 weeks interval. Ninety patients with extensive pityriasis versicolor (body involved area > or =25%) were randomly assigned to treatment with either a single dose of 400 mg of ketoconazole or with two doses of 300 mg of fluconazole with 2 weeks interval. One month after the treatment, the improvement rate and side effects were evaluated by clinical examination and questionnaire. Sixty cases (66.7%) completed the study. They were 51 males and nine females, with a mean age of 30 years. At the follow-up visit (1 month after the end of treatment), the improvement rate for ketoconazole (87.9%) was not significantly different from fluconazole (81.5%), (Fisher test: P = 0.37). Due to the hepatotoxicity of ketoconazole, fluconazole appears to be more suitable in the treatment of extensive pityriasis versicolor.

  6. Study of the distribution of Malassezia species in patients with pityriasis versicolor and healthy individuals in Tehran, Iran

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    Zeraati Hojjat

    2004-05-01

    Full Text Available Abstract Background Pityriasis versicolor is a superficial infection of the stratum corneum which caused by a group of yeasts formerly named pityrosporium. The taxonomy of these lipophilic yeasts has recently been modified and includes seven species referred as Malassezia. The aim of this study is to compare the distribution of Malassezia species isolated from pityriasis versicolor lesions and those isolated from healthy skins. Methods Differentiation of all malassezia species performed using morphological features and physiological test including catalase reaction, Tween assimilation test and splitting of esculin. Results In pityriasis versicolor lesions, the most frequently isolated species was M. globosa (53.3%, followed by M. furfur (25.3%, M. sympodialis(9.3%, M. obtusa (8.1% and M. slooffiae (4.0%. The most frequently isolated species in the skin of healthy individuals were M. globosa, M. sympodialis, M. furfur, M. sloofiae and M. restricta which respectively made up 41.7%, 25.0%, 23.3%, 6.7% and 3.3% of the isolated species. Conclusions According to our data, M. globosa was the most prevalent species in the skin of healthy individuals which recovered only in the yeast form. However, the Mycelial form of M. globosa was isolated as the dominant species from pityriasis versicolor lesions. Therefore, the role of predisposing factors in the conversion of this yeast to mycelium and its subsequent involvement in pityriasis versicolor pathogenicity should be considered.

  7. A Randomized, Double-blind, Placebo-Controlled Study of Efficacy of Oral Acyclovir in the Treatment of Pityriasis Rosea.

    Science.gov (United States)

    Ganguly, Satyaki

    2014-05-01

    Pityriasis rosea is an acute self-limiting skin disorder of unknown aetiology. Recently human herpes virus 6 and 7 has been hypothesized to be the cause of pityriasis rosea. To determine the efficacy of acyclovir, an anti-viral drug, in the treatment of pityriasis rosea. A randomized, double-blind, placebo-controlled study of efficacy of oral acyclovir in the treatment of pityriasis rosea was conducted on 73 patients. Thirty eight randomly selected patients were started on oral acyclovir. Thirty-five patients were prescribed placebo. The patients as well as the chief investigator were unaware of the therapeutic group to which patients belonged (acyclovir or placebo). Patients in both the groups were evaluated clinically after 7 and 14 days following the first visit and the data were analysed. Follow up data of 60 patients was available and these were included in the statistical analysis. 53.33% and 86.66% of the patients belonging to the acyclovir group showed complete resolution on the 7(th) day and 14(th) day respectively following the first visit compared to 10% and 33.33% of patients from the placebo group. The findings were statistically significant. The study showed that high dose acyclovir is effective in the treatment of pityriasis rosea.

  8. [Missing granulocytic infiltrate in pityriasis versicolor--indication of specific anti-inflammatory activity of the pathogen?].

    Science.gov (United States)

    Wroblewski, N; Bär, Silja; Mayser, P

    2005-01-01

    The yeast Malassezia furfur is a part of the resident flora of human skin. It causes various diseases such as pityriasis versicolor, which hardly shows signs of inflammation despite marked clinical symptoms (e.g. hypopigmentation). The pathophysiology related morphological picture might give a clue to this phenomenon. As a part of the literature data are controversial, the present study compared the inflammatory infiltrate of pityriasis versicolor with that of tinea corporis in 40 human skin preparations each from diagnostic specimens. All preparations were stained with HE and PAS. Neutrophilic granulocytes were counted in the HE stain, and hyphae and spores in the PAS stain. The number of counted cells was related to the size of the respective area and the values were compared between pityriasis and tinea corporis. Significantly, more neutrophilic granulocytes were found with tinea corporis (P > 0.01), while they were virtually not demonstrable with pityriasis versicolor. It is surprising that fungal load in the stratum corneum is significantly higher with pityriasis versicolor (P > 0.01). Obviously the immune response involving neutrophilic granulocytes does not occur despite high bacterial load. This might be explained by reduced immunogenicity because of high content of lipids in the cell membrane. Furthermore, pityriarubins that are produced during tryptophan metabolism might be involved, which, in a stimulus-dependent manner, can suppress the ROS production of neutrophilic granulocytes in vivo.

  9. Pityriasis lichenoides: a clonal T-cell lymphoproliferative disorder.

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    Magro, Cynthia; Crowson, A Neil; Kovatich, Al; Burns, Frank

    2002-08-01

    Pityriasis lichenoides (PL) is a papulosquamous disorder often considered a form of reactive dermatosis and classified with small plaque parapsoriasis (digitate dermatosis). However, some patients with PL have developed large plaque parapsoriasis (LPP) and mycosis fungoides (MF), and lymphoid atypia and T-cell clonality have been reported in lesions of PL. We set out to explore the possibility that PL is a form of T-cell dyscrasia. Cases were selected by natural language search from an outpatient dermatopathology database; 35 cases were reviewed and clinicians and patients were contacted. Hematoxylin and eosin-stained sections were examined and immunophenotyping was carried out on paraffin-embedded, formalin-fixed tissue using antibodies to CD2, CD3, CD4, CD5, CD7, CD8, CD20, CD30, and CD56. In paraffin-embedded tissue, T-cell receptor (TCR)-gamma chain rearrangement was sought through polymerase chain reaction single stranded conformational polymorphism analysis. There were 14 males and 21 females with a mean age of 40 years held clinically to have PL chronica (PLC) (28 cases) and/or PL et varioliformis acuta (PLEVA) (7 cases). Five patients developed large atrophic poikilodermatous and/or annular plaques compatible with MF and/or LPP in a background of typical PLC. All biopsies showed tropism of lymphocytes to an epidermis manifesting psoriasiform hyperplasia, dyskeratosis, parakeratosis, and intraepithelial collections of Langerhans' cells and lymphocytes mimicking Pautrier's microabascesses. Epidermal atrophy, dermal fibroplasia, poikilodermatous alterations, and a dominance of intraepidermal cerebriform cells were seen only in patients with chronic persistent disease (i.e., PLC) and in some cases corresponded with clinical progression to MF. All cases had a T cell-dominant infiltrate, with a CD7 deletion in 21 of 32 biopsies examined; the CD7-negative cells were typically the largest and most atypical forms, often in a cohesive array within the upper layers of

  10. Pityriasis Alba--Common Disease, Enigmatic Entity: Up-to-Date Review of the Literature.

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    Miazek, Nina; Michalek, Irmina; Pawlowska-Kisiel, Malgorzata; Olszewska, Malgorzata; Rudnicka, Lidia

    2015-01-01

    Pityriasis alba (PA) is a skin disorder that affects children and adolescents. Although it is common worldwide, its incidence is markedly higher in darker skin phototypes. Its characteristic features include an extended, multistage course and spontaneous remissions and recurrences. Preceded by erythematous changes, patches of hypopigmented skin of up to a few centimeters in diameter appear on the upper body. Pruritus may accompany it. Even though its etiology is unknown, possible reported triggering factors include sunlight, beauty treatments, and microorganisms, among others. Calcineurin inhibitors play the most crucial role in PA pharmacotherapy. PA often coexists with atopic dermatitis and is considered one of its milder forms.

  11. Pityriasis Rosea with Erythema Multiforme – Like Lesions: An Observational Analysis

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    Relhan, Vineet; Sinha, Surabhi; Garg, Vijay K; Khurana, Nita

    2013-01-01

    Pityriasis rosea (PR) is an acute or subacute inflammatory skin disease characterized by erythematous papulosquamous eruptions localized on the trunk and arms. The eruptions are self-limiting and usually disappear gradually in 2-10 weeks, without any treatment. Typical PR is much easier to diagnose than the rare atypical forms. There is a passing mention of PR with erythema multiforme-like lesions in the literature, but no extensive case series have been published till date. We present a series of five patients for whom we believe atypical PR is the likely diagnosis. PMID:23723495

  12. Sofosbuvir-Induced Erythrodermic Pityriasis Rubra Pilaris-Like Drug Eruption.

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    Cheung, Evelyn J; Jedrych, Jaroslaw J; English, Joseph C

    2015-10-01

    Until 2011, the standard-of-care therapy for patients with hepatitis C consisted of interferon and ribavirin. The recent advent of new targeted therapies against this virus has provided more options of treatment for infected patients. Sofosbuvir, a nucleotide inhibitor of hepatitis C virus (HCV) RNA polymerase, was recently approved by the US Food and Drug Administration in 2013. Various Phase 3 trials with sofosbuvir combination therapy have reported an incidence of rash between 7% and 18%. We here describe a case of sofosbuvir-induced erythrodermic pityriasis rubra pilaris-like drug eruption.

  13. Acantholytic Pityriasis Rubra Pilaris Associated with Imiquimod 3.75% Application

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    Natasha Atanaskova Mesinkovska

    2011-01-01

    Full Text Available Imiquimod is an immunomodulator with both antitumor and antiviral properties. It is currently available in two cream formulations as Aldara (imiquimod 5% and the newly approved Zyclara (imiquimod 3.75%. Imiquimod has been associated with localized erythema, crusting, and scaling at the site of application. However, more severe generalized skin eruptions including erythema multiforme, psoriasis, and hyperpigmentation have been described. The newly approved imiquimod 3.75% cream is a presumably safer alternative due to its lower concentration. This paper describes the development of generalized acantholytic pityriasis rubra pilaris after the treatment of an actinic keratosis on the forehead with imiquimod 3.75% cream.

  14. Lichen striatus and pityriasis lichenoides chronica in an 11-year-old girl: An etiologic relationship?

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    Erpolat, Seval; Yenidunya, Sibel

    2015-09-01

    Lichen striatusis a rare linear papulardermatosis that primarily occurs in children. The lesions have a linear distribution following Blaschko's lines. Pityriasis lichenoides is an uncommon benign skin disorder with two major variants: acute and chronic.Herein, we report the case of an 11-year-old girl with concurrent pityriasisli chenoides chronica and lichen striatus, a previously unreported association. Although it remains unclear whether there is an aetiological relationship between the two diseases or whether their coexistence was coincidental in our patient, but some common mechanisms may be involved in the two diseases.

  15. Acute cutaneous graft-versus-host disease resembling type II (atypical adult) pityriasis rubra pilaris.

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    Surjana, Devita; Robertson, Ivan; Kennedy, Glen; James, Daniel; Weedon, David

    2015-02-01

    We present a case of cutaneous acute graft-versus-host disease (aGVHD) with confluent erythematous perifollicular hyperkeratosis and ichthyosiform scale in the clinical pattern of type II (atypical adult) pityriasis rubra pilaris (PRP), which developed 26 days after allogeneic peripheral blood stem cell transplant. Skin histology confirmed features of both aGVHD and PRP. The skin lesions were refractory to oral prednisolone and cyclosporine and only partially responsive to a combination of i.v. methylprednisolone, oral tacrolimus, oral mycophenolate mofetil, and infusions of anti-thymocyte globulin and the tumour necrosis factor-α inhibitor, etanercept. © 2013 The Australasian College of Dermatologists.

  16. Pityriasis Rubra Pilaris: A Report of Two Cases and Literature Review

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    Paravina Mirjana

    2015-12-01

    Full Text Available Pityriasis rubra pilaris (PRP is an idiopathic inflammatory hyperproliferative chronic dermatosis characterized by: perifollicular coalescing papules with central keratotic acuminate plugs gradually submerged in sheets of erythema; perifollicular erythema with islands of unaffected skin; palmoplantar keratoderma; diffuse desquamation which typically spreads from the head down to the feet. The cause of the condition is unknown, but possible etiological factors include: vitamin A deficiency, trauma, infections, autoimmune mechanisms, and malignancies. Taking into account different age of onset, clinical course, morphology and prognosis, there are six different types of the disease: two in adults (classical and atypical; three in children (classical, circumscribed and atypical; one in individuals infected with human immunodeficiency virus.

  17. Humoral immunity to Malassezia furfur serovars A, B and C in patients with pityriasis versicolor, seborrheic dermatitis and controls.

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    Ashbee, H R; Fruin, A; Holland, K T; Cunliffe, W J; Ingham, E

    1994-10-01

    This study examined the humoral immune responses to Malassezia furfur serovars A, B and C of 10 patients with pityriasis versicolor, 10 patients with seborrheic dermatitis and 20 age- and sex-matched controls. A transferable solid-phase ELISA was used to determine titres of total Igs, IgM, IgA and IgG specific to M. furfur serovars A, B and C. The results demonstrated that patients with seborrheic dermatitis had a significantly higher titre of total Igs to serovar A than patients with pityriasis versicolor; and that patients with seborrheic dermatitis had a significantly higher titre of IgA to serovar C than patients with pityriasis versicolor. The titres of total Igs for controls and patients with seborrheic dermatitis were significantly lower to serovar B than to serovar C. A modified TSP ELISA was used to determine the titres of the IgG subclasses. Titres of IgG1,3,4 to serovar B were significantly higher in seborrheic dermatitis patients than pityriasis versicolor patients and titres of IgG3 to serovar A were significantly higher in seborrheic dermatitis patients than pityriasis versicolor patients. However, despite the differences between the patient groups, none of these results was significantly different to those of controls. Thus, this study did not demonstrate any differences in humoral immunity of patients suffering from Malassezia-associated dermatoses when compared to normal controls. These results may suggest that the humoral immune response to M. furfur is not related to the pathogenesis of Malassezia-associated dermatoses, but simply to the carriage of M. furfur on the skin.

  18. Expression of antimicrobial peptides and toll-like receptors is increased in tinea and pityriasis versicolor.

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    Brasch, J; Mörig, A; Neumann, B; Proksch, E

    2014-03-01

    In superficial tinea and pityriasis versicolor, the causative fungi are for the most part confined to the stratum corneum which is barely reached by leukocytes. Therefore, a role of non-cellular components in the epidermal antifungal defence was suggested. To investigate the presence of such factors in these infections, the expression of human beta defensins 2 and 3 (hBD-2, hBD-3), RNase 7, psoriasin, toll-like receptors 2, 4 and 9 (TLR2, TLR4 and TLR9) and dectin 2 was analysed by use of immunostainings in skin biopsies. We found that hBD2, hBD3, psoriasin, RNase7, TLR2 and TLR4 were significantly more often expressed in distinct layers of lesional epidermis as compared with uninfected epidermis. In both infections but not in normal skin, hBD2 and hBD3 were commonly expressed within the stratum corneum and in the stratum granulosum. Similarly, psoriasin was seen more often in the upper skin layers of both infections as compared with normal skin. No significant differences between normal and infected skin were found for the expression of TLR9 and dectin 2. Our findings clearly show the expression of specific antimicrobial proteins and defence-related ligands in superficial tinea as well as in pityriasis versicolor, suggesting that these factors contribute to fungal containment. © 2013 Blackwell Verlag GmbH.

  19. Distribution of Malassezia species in patients with pityriasis versicolor in Northern Iran

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    Shokohi T

    2009-01-01

    Full Text Available Purpose : Malassezia yeasts are globally distributed agents of pityriasis versicolor and are implicated in the pathogenesis of seborrhoeic and atopic dermatitis. The aim of this study is to identify the Malassezia species obtained from pityriasis versicolor patients, using morphological, biochemical, physiological as well as Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP methods. Materials and Methods: The identification of Malassezia species is performed according to microscopic features and physiological characteristics, including catalase reaction and Tween assimilation tests. The DNA is extracted from cultured Malassezia using the glass bead, phenol-chloroform method. The internal transcribed spacer 1(ITS1 region is amplified and there is restricted digestion of the PCR products with two enzymes Cfo I and Bst F5I. Results : The most commonly isolated species is M. globosa (47.6%. RFLP analysis of the PCR products of the ITS1 region is in complete agreement with those from the DNA sequences of the internal transcribed spacer (ITS 1 region and the biochemical tests. Conclusion : Based on the findings of this study, it can be concluded that PCR-RFLP is a relatively simple and quick method, completely comparable to the routine methods used for Malassezia identification.

  20. Pityriasis lichenoides et varioliformis acuta in skin of color: new observations by dermoscopy

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    Ankad, Balachandra S.; Beergouder, Savitha L.

    2017-01-01

    Background Pityriasis lichenoides is an uncommon skin disease that presents in three different forms: pityriasis lichenoides et varioliformis acuta (PLEVA), pityriasis lichenoides chronica (PLC) and febrile ulceronecrotic-Mucha-Habermann disease. These represent a spectrum of a disease. PLEVA presents as skin eruption of multiple, small, red papules that develop into polymorphic lesions with periods of varying remissions, as well as possible sequels of hyper/hypopigmentation and varicella-like scars. Diagnosis of this condition is mainly clinical, and sometimes clinical differentiation from other conditions may be a difficult task that often requires histological analysis. In this study, PLEVA lesions were examined by dermoscopy, and the significance of specific dermoscopic findings was investigated in order to facilitate their differentiation from other inflammatory conditions. Objectives To evaluate dermoscopic patterns in PLEVA and to correlate these patterns with histopathology. Materials and methods The study was conducted at S. Nijalingappa Medical College, Bagalkot. It was an observational case series study and patients were selected randomly. Ethical clearance and informed consent were obtained. PLEVA lesions in early and late phases were evaluated. A manual DermLite 3 (3Gen, San Juan Capistrano, CA) dermoscope attached to a Sony (Cyber Shot DSC-W800, Sony Electronics Inc., San Diego, California, USA, digital, 14 mega pixels) camera was employed. Histopathology was done to confirm the diagnosis. Data was collected and analyzed. Results were statistically described in terms of frequencies and types of dermoscopic patterns. Results There was a total of 14 patients; 8 males and 6 females. Mean age of patients was 19 years. Mean duration of disease was 7 months. Dermoscopy in early-phase lesions revealed amorphous brownish areas around the hair follicles, dotted vessels, and scaling. Dermoscopy in late-phase lesions showed whitish-structureless areas and

  1. Pityriasis lichenoides et varioliformis acuta in skin of color: new observations by dermoscopy.

    Science.gov (United States)

    Ankad, Balachandra S; Beergouder, Savitha L

    2017-01-01

    Pityriasis lichenoides is an uncommon skin disease that presents in three different forms: pityriasis lichenoides et varioliformis acuta (PLEVA), pityriasis lichenoides chronica (PLC) and febrile ulceronecrotic-Mucha-Habermann disease. These represent a spectrum of a disease. PLEVA presents as skin eruption of multiple, small, red papules that develop into polymorphic lesions with periods of varying remissions, as well as possible sequels of hyper/hypopigmentation and varicella-like scars. Diagnosis of this condition is mainly clinical, and sometimes clinical differentiation from other conditions may be a difficult task that often requires histological analysis. In this study, PLEVA lesions were examined by dermoscopy, and the significance of specific dermoscopic findings was investigated in order to facilitate their differentiation from other inflammatory conditions. To evaluate dermoscopic patterns in PLEVA and to correlate these patterns with histopathology. The study was conducted at S. Nijalingappa Medical College, Bagalkot. It was an observational case series study and patients were selected randomly. Ethical clearance and informed consent were obtained. PLEVA lesions in early and late phases were evaluated. A manual DermLite 3 (3Gen, San Juan Capistrano, CA) dermoscope attached to a Sony (Cyber Shot DSC-W800, Sony Electronics Inc., San Diego, California, USA, digital, 14 mega pixels) camera was employed. Histopathology was done to confirm the diagnosis. Data was collected and analyzed. Results were statistically described in terms of frequencies and types of dermoscopic patterns. There was a total of 14 patients; 8 males and 6 females. Mean age of patients was 19 years. Mean duration of disease was 7 months. Dermoscopy in early-phase lesions revealed amorphous brownish areas around the hair follicles, dotted vessels, and scaling. Dermoscopy in late-phase lesions showed whitish-structureless areas and central white crust within whitish-structureless rim with

  2. Pityriasis rosea-like drug eruption due to bupropion: a case report.

    Science.gov (United States)

    Polat, M; Uzun, Ö; Örs, I; Boran, Ç

    2014-12-01

    Pityriasis rosea (PR) is a common, acute, and self-limited inflammatory skin disease. The typical clinical presentation includes the appearance of a primary "herald" patch followed within days to weeks by the onset of secondary scaly skin eruptions distributed along the skin tension line in most cases. Although PR is a well-known and relatively common disease, its cause is still not completely understood. However, viral agents, autoimmunity, psychogenic status, and numerous drugs have been proposed as possible factors to PR. Bupropion is known to cause hypersensitivity reactions. We present a clinical case of PR eruption caused by the use of bupropion. To the best of our knowledge, this is the first published case of PR associated with bupropion use. © The Author(s) 2014.

  3. A case of pityriasis rubra pilaris with associated focal acantholytic dyskeratosis complicated by Kaposi's varicelliform eruption.

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    Erdag, Gulsun; Lockman, Deborah; Tromberg, Jennifer; Cropley, Thomas; Patterson, James W

    2011-11-01

    The clinical and histopathological diagnosis of pityriasis rubra pilaris (PRP) can be difficult because clinical findings are often subtle in early stages, and microscopic findings can overlap with those of other skin diseases. Focal acantholytic dyskeratosis (FAD) can rarely be seen in PRP and can mimic Darier's disease, Grover's disease or other disorders characterized by these histopathologic features. Kaposi's varicelliform eruption is a widespread infection due to herpes simplex virus (HSV) types 1 and 2, coxsackievirus A16 or vaccinia virus, occurring in a preexisting dermatosis; only one case has been reported in PRP. We report a patient with PRP whose biopsies showed both herpes simplex infection and FAD. A complete understanding of the mechanism behind this eruption evolved gradually, aided in great measure by the histopathologic findings. Copyright © 2011 John Wiley & Sons A/S.

  4. Type I pityriasis rubra pilaris: upregulation of tumor necrosis factor alpha and response to adalimumab therapy.

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    Zhang, Yao-Hua; Zhou, Youwen; Ball, Nigel; Su, Ming-Wan; Xu, Jin-Hua; Zheng, Zhi-Zhong

    2010-01-01

    pityriasis rubra pilaris (PRP) has unknown etiology and is often refractory to conventional therapies. to document a PRP patient's response to adalimumab therapy and to highlight the potential role of tumor necrosis factor (TNF) in the development of PRP skin lesions. a patient received adalimumab therapy at standard dosing intervals. In addition, the messenger ribonucleic acid (mRNA) of TNF in the lesional and perilesional normal skin was quantified in two patients with PRP. the patient responded to adalimumab therapy and achieved clinical remission by 4 months. There was a significant elevation of TNF mRNA in the lesional skin of PRP. TNF upregulation is detected in PRP lesional skin, consistent with the observed clinical efficacy of TNF blockade for the treatment of PRP.

  5. Comparative study of ketoconazole versus selenium sulphide shampoo in pityriasis versicolor

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    Aggarwal K

    2003-03-01

    Full Text Available Forty patients suffering from pityriasis versicolor were treated with either 2% ketoconazole shampoo (20 patients or 2.5% selenium sulphide shampoo (20 patients, once a week for three weeks. On global assessment after one month of start of therapy, 19 (95% out of 20 patients treated with ketoconazole shampoo were cured while one case had mild residual disease. In selenium sulphide shampoo group, 17 (85% out of 20 patients were cured, one had mild residual disease and two had considerable residual disease. No significant difference was observed in the response rates in the two groups. Relapse occurred in one patient of ketoconazole group and two patients of selenium sulphide group during the follow - up period of three months.

  6. Comparative clinicopathological study on pityriasis lichenoides chronica and small plaque parapsoriasis.

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    Benmamán, O; Sánchez, J L

    1988-06-01

    The term parapsoriasis refers to a group of chronic asymptomatic scaly dermatoses of unknown etiology about which there is still controversy over the nosology and nomenclature of the different conditions that comprise the group, particularly pityriasis lichenoides chronica (PLC) and small plaque parapsoriasis (SPP). In an attempt to establish the distinctive clinicopathologic features of these two dermatosis, we prospectively studied 44 patients who presented with the typical clinical and histologic picture of either of these two diseases. SPP was clinically characterized by scaly oval plaques on the trunk and proximal aspect of extremities. Spongiosis was the salient histopathologic feature, with absence of fibrosis or melanophages. PLC presented with a scaly papular eruption over the trunk and extremities and histologically was characterized by an interface dermatitis. We conclude that sufficient clinical and histologic features differentiate these two entities and we propose that the term parapsoriasis be used only to designate SPP and large plaque parapsoriasis.

  7. Evaluation of Demographics and Climatic Factors/Disease Relationship in Patients with Pityriasis Rosea

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    Emel Bülbül Başkan

    2011-06-01

    Full Text Available Background and Design: Pityriasis rosea (PR is an acute onset, self-limiting papulosquamous skin disease. The etiology of the disease is totally unknown, however, many epidemiological and clinical studies have suggested that infectious agents may cause the disease. Seasonal changes in the incidence may be an epidemiologic evidence for potential infectious etiology. In this study, we aimed to analyze the demographic data of PR patients and to explore the role of climatic factors in the etiology of the disease. Material and Method: We retrospectively reviewed the patient files of PR cases that had been followed up in our clinic between 2000 and 2005. Demographic data of the patients as well as the date of applications were recorded. Temperature, raining, pressure and humidity data for the City of Bursa for years 2000-2005 were obtained from the General Directorate of Meteorology, Republic of Turkey. Any potential relationship between onset time of PR and meteorological parameters was investigated statistically by using cluster analysis. Results: We reviewed the medical records of 413 patients, of whom 271 were female and 142 were male. Herald plaque was seen in 88 patients (21.3%. Pityriasis rosea was observed predominantly in persons between 20 and 29 years of age (139 patients; 33.6%. Distribution of number of cases between 2000-2005 was 51, 57, 80, 75, 63, 87. The highest number of patients was seen in winter (n: 122; 29.5% followed by spring (n: 101; 24.4%, autumn (n: 101; 24.4% and summer (n: 89; 21.7%. No statistically significant difference was found between annual and seasonal changes in the incidence of PR (p>0.05.Conclusion: We conclude that although the relation between PR and seasonal factors was not statistically significant in our study, multi-centric studies on large series of patients are needed to further investigate this topic.

  8. Detection of Malassezia Species Isolated From Patients With Pityriasis Versicolor and Seborrheic Dermatitis Using Nested-PCR

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    Zarei Mahmoudabadi

    2014-12-01

    Full Text Available Background The species of the genus Malassezia are lipophilic and dimorphic yeasts that are regarded as part of the normal flora of the skin of humans and warm-blooded animals. These organisms are the cause of superficial mycosis in humans and other animals, and are common in pityriasis versicolor and seborrheic dermatitis. Objectives The purpose of this study was to determine the frequency of common Malassezia species in patients affected by pityriasis versicolor and seborrheic dermatitis using of the nested PCR method, in the city of Ahvaz. Patients and Methods In the present study, 85 samples from patients with pityriasis versicolor and seborrheic dermatitis were analyzed by the nested-PCR method. During the first stage, the internal transcribed spacer (ITS region from the ribosomal DNA was reproduced using primers ITS4-R and ITS1F-N. During the second stage, the product of the first step was used as DNA and using three special primer pairs, including Mf-F, 5.8SR and M.gl-F, 5.8SR and M.rt-F and M.rt-R, the inner part of the first phase was detected. Results The most common isolate was Malassezia furfur (51.3% followed by M. globosa (35.2% and M. restricta (13.5%. Amongst the 30 patients with seborrheic dermatitis, in 15 cases (65.2% M. restricta, in six cases (26.1% M. globosa and in two cases (8.7% M. furfur was detected and in seven patients no isolate was detected. Conclusions The nested-PCR is a rapid and repeatable method for identification of important Malassezia species and this method is recommended for use on more patients. In addition the most common agents of pityriasis versicolor and seborrheic dermatitis were M. furfur and M. restricta, respectively.

  9. The diagnostic criteria of pityriasis rosea and Gianotti-Crosti syndrome - a protocol to establish diagnostic criteria of skin diseases.

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    Chuh, A; Zawar, V; Sciallis, G F; Lee, A

    2015-01-01

    We established and validated diagnostic criteria for pityriasis rosea and Gianotti-Crosti syndrome. In this paper, we compare and contrast both diagnostic criteria to formulate a protocol in establishing diagnostic criteria for other dermatological diseases. The diagnostic criteria are similar in employing clear dividing lines and conjunctions ('and/or') to assure high reliability. Both sets of criteria should be applicable for all ethnic groups. Spontaneous remission is not included, so diagnosis is not delayed while waiting for disease remission. Laboratory investigations are not enlisted, so that the criteria can be used in medical care systems in different parts of the world. The diagnostic criteria are different in that pathognomonic clinical manifestations exist for pityriasis rosea, such as the herald patch and the orientation of lesions along the lines of skin cleavages. These features, however, score low for sensitivity. These specific manifestations are not seen in Gianotti-Crosti syndrome. Such differences led to different categorisation of clinical features. Atypical variants are more common for pityriasis rosea. The diagnostic criteria for pityriasis rosea therefore do not include a list of differential diagnoses, while diagnostic criteria for Gianotti-Crosti syndrome do. Using this comparison, we constructed a protocol to establish diagnostic criteria for other skin diseases. We advocate the need to justify the establishment of diagnostic criteria, that multiple diagnostic criteria for the same disease should be avoided, that diagnostic criteria should be compatible with the disease classification if applicable, and that the scope should be well-delineated with regard to clinical variants. We outline the need for validation studies to assess the criteria-related validity, test-retest intra-clinician reliability, and inter-clinician reliability. We emphasise that the establishment of diagnostic criteria should not be a generic process. We also

  10. Randomized comparative clinical trial of artemisia sieberi 5% lotion and clotrimazole 1% lotion for the treatment of pityriasis versicolor

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    Rad Farrokh

    2008-01-01

    Full Text Available Aims: To compare the therapeutic effects of topical Artremisia sieberi 5% lotion with topical clotrimazole 1% lotion in the treatment of pityriasis versicolor. Materials and Methods: 100 patients with pityriasis versicolor and microscopic identification of Malassezia furfur were randomly assigned to treatment with either topical Artemisia sieberi 5% lotion (group 1 or topical clotrimazole 1% lotion (group 2 for 2 weeks. Group 1 and group 2 consisted of 51 and 49 patients respectively. The patients were evaluated both clinically and mycologically at baseline and every 2 weeks for a period of 4 weeks. Results: At the end of the second week, clinical cure rates were 86.3% and 65.3% for group 1 and group 2 respectively ( P < 0.01, but at the same time mycological cure rate was 92.2% for group 1 and 73.5% for group 2 ( P < 0.05. At the end of the fourth week, clinical cure rates were 86.3% and 59.2% for group 1 and group 2 respectively ( P < 0.01, and at the same time mycologic cure rate was 96.1% for group 1 and 65.3% for group 2 ( P < 0.01. Conclusions: The results of this study demonstrated that Artemisia sieberi 5% lotion was more effective than clotrimazole 1% lotion in the treatment of pityriasis versicolor.

  11. Identification of Malassezia Species Isolated from Patients with Pityriasis Versicolor Using PCR-RFLP Method in Markazi Province, Central Iran.

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    Mojtaba Didehdar

    2014-05-01

    Full Text Available The lipophilic yeasts of Malassezia species are members of the normal skin microbial that are cause of pityriasis versicolor. Pityriasis versicolor is a common superficial fungal infection with world-wide distribution. The phenotypic methods for identification of Malassezia species usually are time consuming and unreliable to differentiate newly identified species. But DNA-based techniques rapidly and accurately identified Malassezia species. The purpose of this study was isolation and identification of Malassezia Species from patients with pityriasis versicolor by molecular methods in Markazi Province, Central Iran in 2012.Mycologic examinations including direct microscopy and culture were performed on clinical samples. DNA extraction was performed from colonies. The ITS1 region of rDNA from isolates of Malassezia species were amplified by PCR reaction. The PCR were digested by Cfo I enzyme.From 70 skin samples, were microscopically positive for Malassezia elements, 60 samples were grown on culture medium (85.7%. Using PCR-RFLP method, that was performed on 60 isolates, 37(61.6% M. globosa, 14(23.3% M. furfur, 5(8.4% M. sympodialis and 4(6.7% M. restrictawere identified. In one case was isolated M. globosa along with M. restricta.The PCR-RFLP method is a useful and reliable technique for identification of differentiation of Malas-sezia species.

  12. Identification of Malassezia species isolated from patients with seborrhoeic dermatitis, atopic dermatitis, pityriasis versicolor and normal subjects.

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    Nakabayashi, A; Sei, Y; Guillot, J

    2000-10-01

    We identified Malassezia species isolated from 42 patients with seborrhoeic dermatitis, 17 patients with atopic dermatitis, 22 patients with pityriasis versicolor, 35 normal subjects and 73 healthy medical students. Regarding the prevalence of Malassezia species in the 35 normal subjects, the frequency of isolation of Malassezia globosa was 22%, M. sympodialis 10% and M. furfur 3%. M. slooffiae, M. pachydermatis, M. restricta and M. obtusa were infrequently isolated from normal skin. Two different species were isolated coincidentally from seven samples. In the patients with atopic dermatitis, M. furfur was isolated more frequently from lesional skin (21%) than non-lesional skin (11%). However, there was no statistical significance. Therefore, this result, by itself, is insufficient to prove that M. furfur should be considered to be an exacerbating factor of atopic dermatitis. In seborrhoeic dermatitis, M. furfur (35%) and M. globosa (22%) were isolated from lesional skin on the face at significantly high rates in comparison with the normal subjects. Therefore, M. furfur and/or M. globosa may be pathogens of seborrhoeic dermatitis. M. globosa was isolated at a frequency of 55% from lesional skin of pityriasis versicolor, while all other species were below 10%. These data suggest that the pathogenic species of pityriasis versicolor is M. globosa.

  13. [Levels of selenium in urine after treatment of pityriasis versicolor with a 1.0% selenium sulfide].

    Science.gov (United States)

    Costa Martins, J E; Macedo De Souza, E; Salebian, A; Sampaio, S A

    1976-01-01

    The treatment of pityriasis versicolor by the topical application of selenium sulfide 1% was studied in two groups of patients. Diagnosis and response to therapy was determined by clinical observation. Wood's light fluorescence, and direct microscopic examination. The efficacy of three different therapeutic regimes was studied in one group by the application of the drug to the entire skin for either five minutes, fifteen minutes, or twelve hours for eighteen days. Each method proved equally effective in resolving the infection. Therefore, the cutaneous application of selenium sulfide 1 % for five minutes daily for eighteen days is the recommended treatment for pityriasis versicolor. The percutaneous absorption of selenium sulfide was also studied in another groups who applied the drug to the entire skin for five minutes for eighteen days. Fluorimetric analysis of urinary samples collected on the third and thirteenth days of treatment revealed no significant increase in the excretion of selenium as compared to pretreatment levels. Systemic toxicity was not observed in any of the patients treated. The results suggest that the selenium sulfide is absorbed poorly from the skin and is a safe and effective therapy for pityriasis versicolor.

  14. A reappraisal of the role of Pityrosporum orbiculare in pityriasis versicolor and the significance of extracellular lipase.

    Science.gov (United States)

    Catterall, M D; Ward, M E; Jacobs, P

    1978-12-01

    Pityrosporum orbiculare is an obligate lipophilic yeast in vitro, which suggests it possesses an extracellular lipase crucial for nutrition. If present in vivo, the enzyme would enable the yeast to utilize skin surface lipids, which may therfore play an important role in the pathogenesis of pityriasis versicolor. Cultured P. orbiculare and biopsy material from patients with pityriasis versicolor were investigated for the presence of lipase by electron microscope histochemistry. At sites of lipase activity, fatty acid hydrolyzed from Tween 80 substrate reacts with Ca++ ions to form an insoluble Ca++ soap. Exchange of Ca++ with Pb++ enables the sites of lipase activity to be visualized as electron dense deposits of insoluble lead soap. Surface lipase activity was apparent when the technique was applied to P. orbiculare grown on lipid containing medium and its specificity confirmed by removal of substrate and inhibition by di-isopropyl fluorophosphate and quinine hydrochloride, but not by sodium fluoride. When the same technique was applied to stratum corneum infected with Pityrosporum furfur (Malassez), no reaction product could be detected. It is postulated that lipase, although critical for fungal nutrition in vitro, is unlikely to be of importance in vivo. Skin surface lipids are therefore probably not relevant to the pathogenesis of pityriasis versicolor.

  15. Pityriasis Rosea

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    ... Boards study tools Online Learning Center Meetings and events Make a difference Career planning Media Relations Toolkit AAD apps Academy meeting Chronic urticaria—for members Chronic urticaria—for public Dermatology World Dialogues in Dermatology JAAD Mohs AUC ...

  16. Pityriasis Rosea

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    ... Genitals and Urinary Tract Glands & Growth Head Neck & Nervous System Heart Infections Learning Disabilities Obesity Orthopedic Prevention Sexually Transmitted Skin Tobacco Treatments Injuries & ...

  17. Ustekinumab as an Alternative Treatment Option for Chronic Pityriasis Rubra Pilaris

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    Mudit Chowdhary

    2015-03-01

    Full Text Available Pityriasis rubra pilaris (PRP is an exceptionally rare, chronic inflammatory dermatosis of unknown etiology. Patients classically present with small, follicular keratosis and salmon-colored plaques that begin at the head and neck and slowly progress to widespread erythroderma including the palms and soles. It is difficult to distinguish PRP from other inflammatory dermatoses; however, features that help aid in the diagnosis include ‘islands' of spared skin, orangish hue and typical findings on biopsy. There are no specific guidelines on therapy and treatment options include corticosteroids, vitamin D analogs, retinoids, methotrexate, cyclosporine, azathioprine and tumor necrosis factor alpha antagonists. Unfortunately options are limited for patients when these drugs do not work. We report a case of chronic PRP, refractory to conventional treatment, successfully treated with ustekinumab monotherapy. The patient was treated with 90 mg subcutaneous ustekinumab injections and began to show improvement within only 8 weeks. Long-term control of the disease has been attained without any significant side effects. We report this case to show that ustekinumab can be used as an alternative treatment method for patients with chronic, unremitting PRP. Treatment response is remarkably rapid and the infrequent dosing leads to patient compliance and a significantly improved quality of life.

  18. Papulopustular rosacea, skin immunity and Demodex: pityriasis folliculorum as a missing link.

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    Forton, F M N

    2012-01-01

    Papulopustular rosacea (PPR) is a common facial skin disease, characterized by erythema, telangiectasia, papules and pustules. Its physiopathology is still being discussed, but recently several molecular features of its inflammatory process have been identified: an overproduction of Toll-Like receptors 2, of a serine protease, and of abnormal forms of cathelicidin. The two factors which stimulate the Toll-like receptors to induce cathelicidin expression are skin infection and cutaneous barrier disruption: these two conditions are, at least theoretically, fulfilled by Demodex, which is present in high density in PPR and creates epithelial breaches by eating cells. So, the major pathogenic mechanisms of Demodex and its role in PPR are reviewed here in the context of these recent discoveries. In this review, the inflammatory process of PPR appears to be a consequence of the proliferation of Demodex, and strongly supports the hypothesis that: (1) in the first stage a specific (innate or acquired) immune defect against Demodex allows the proliferation of the mite; (2) in the second stage, probably when some mites penetrate into the dermis, the immune system is suddenly stimulated and gives rise to an exaggerated immune response against the Demodex, resulting in the papules and the pustules of the rosacea. In this context, it would be very interesting to study the immune molecular features of this first stage, named "pityriasis folliculorum", where the Demodex proliferate profusely with no, or a low immune reaction from the host: this entity appears to be a missing link in the understanding of rosacea.

  19. Is narrowband ultraviolet B monotherapy effective in the treatment of pityriasis lichenoides?

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    Park, Jung-Min; Jwa, Seung-Wook; Song, Margaret; Kim, Hoon-Soo; Chin, Hyun-Woo; Ko, Hyun-Chang; Kim, Moon-Bum; Kim, Byung-Soo

    2013-08-01

    Pityriasis lichenoides (PL) is a self-limiting papulosquamous disease that may persist for years and is associated with a high relapse rate. To date, few comparative studies have investigated the efficacy of narrowband ultraviolet B (NB-UVB) phototherapy and other therapies in the treatment of PL. The present study retrospectively compared the clinical efficacies of NB-UVB phototherapy, systemic therapy, and a combination of NB-UVB and systemic medication in the treatment of PL. Seventy patients diagnosed with PL were enrolled in this study. They were divided into three subgroups: the NB-UVB treatment group; the systemic treatment group; and the combination treatment group. Therapeutic efficacy was evaluated according to whether the subjects demonstrated a complete response (> 90% improvement in skin lesions), partial response (50-90% improvement), or no response (< 50% improvement) to treatment. A 91.9% complete response rate was achieved in the NB-UVB group, whereas only 69.2 and 80.0% of patients achieved a complete response in the systemic and combination treatment groups, respectively; these differences were not statistically significant. The mean treatment periods were 8.3, 5.3, and 7.9 weeks in the NB-UVB, systemic, and combination treatment groups, respectively; these differences were also not significant. Monotherapy using NB-UVB is effective in achieving a complete response in the treatment of PL and thus eliminates the need for concurrent systemic medication. © 2013 The International Society of Dermatology.

  20. Higher Expression of Toll-like Receptors 3, 7, 8, and 9 in Pityriasis Rosea

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    Mostafa Abou El-Ela

    2017-03-01

    Full Text Available Background Pityriasis rosea (PR is a common papulosquamous skin disease in which an infective agent may be implicated. Toll-like receptors (TLRs play an important role in immune responses and in the pathophysiology of inflammatory skin diseases. Our aim was to determine the possible roles of TLRs 3, 7, 8, and 9 in the pathogenesis of PR. Methods Twenty-four PR patients and 24 healthy individuals (as controls were included in this case control study. All recruits were subjected to routine laboratory investigations. Biopsies were obtained from one active PR lesion and from healthy skin of controls for the detection of TLR 3, 7, 8, and 9 gene expression using real-time polymerase chain reaction. Results This study included 24 patients (8 females and 16 males with active PR lesions, with a mean age of 28.62 years. Twenty four healthy age- and sex-matched individuals were included as controls (8 females and 16 males, with a mean age of 30.83 years. The results of the routine laboratory tests revealed no significant differences between both groups. Significantly elevated expression of all studied TLRs were detected in PR patients relative to healthy controls (p < .001. Conclusions TLRs 3, 7, 8, and 9 might be involved in the pathogenesis of PR.

  1. The spectrum of Malassezia species isolated from students with pityriasis vesicolor in Nigeria.

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    Ibekwe, P U; Ogunbiyi, A O; Besch, R; Ruzicka, T; Sárdy, M

    2015-04-01

    Pityriasis versicolor (PV) is a common superficial fungal infection of the skin caused by Malassezia. Initially M. furfur was suggested as its main aetiological agent; however, more recent studies suggest M. globosa as the dominant species. The possibility of a variance in predominant species based on geographical basis has not been fully evaluated. The objective of this study was to identify the Malassezia species on affected and non-affected skin of students with PV who reside in a tropical environment (Abuja, Nigeria) and correlate them to clinical characteristics. In this study, the literature on prevalence of Malassezia genus in PV was also reviewed. Samples were taken from 304 PV lesions and 110 normal appearing skin. Microscopy, culture and identification of Malassezia species utilising polymerase chain reaction-restriction fragment length polymorphism analysis were performed. Three Malassezia species were detected in PV with the major species being M. furfur. On normal appearing skin, M. furfur (77.6%) and M. restricta (10.4%) were both detected. No case of M. globosa was identified in this study. There was no significant difference between species identified and clinical features of PV. M. furfur is probably still the most predominant species causing PV in the tropical environment. © 2015 Blackwell Verlag GmbH.

  2. Human Herpes Virus-6 and Human Herpes Virus -7 in Pityriasis Rosea

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    Kıymet Baz

    2013-09-01

    Full Text Available Objective: The etiology of pityriasis rosea (PR remains unknown despite numerous investigations. In recent years, human herpes virus-6 (HHV-6 and HHV-7 were accused as causative agents in PR. The aim of this study was to evaluate the possible role of HHV-6 and HHV-7 in the pathogenesis of PR. Methods: Twenty three PR patients and 23 healthy blood donors as a control group were included in the study. Polymerase chain reaction (PCR with specific primers for HHV-6 and HHV-7 DNA sequences was performed on the serum samples of 23 active PR patients and controls, and also the lesional skin biopsies from 11 PR patients. Additionally, serum levels of IgM antibodies againts HHV-7 were detected by using indirect immunofluorescence test on the serum samples of all of the study population. Results: No statistically significant differences were detected between PR patients and controls regarding all serum results. Conclusion: These findings do not support a primary etiological role for HHV-6 and HHV-7 in PR as in some previous studies.

  3. Pityriasis Lichenoides et Varioliformis Acuta Due to Infection: A Case Report

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    Sibel Tekin

    2009-12-01

    Full Text Available A nine-year old girl admitted to our clinic with two months history of itchy skin eruption, initially started on the arms and then disseminated to all the body including the face. Dermatological examination revealed extensive papulosquamous lesions covered with hemorrhagic crust and central necrosis. Clinically the diagnosis was thought to be pityriasis lichenoides et varioliformis acuta (PLEVA and a skin biopsy was performed from a lesion which revealed exocytosis and spongiosis in epidermis, edema and exocytosis of erythrocytes in papillary dermis, perivascular lymphocytic infiltration in dermis. In laboratory evaluation, oropharyngeal culture was positive for Streptococcus pyogenes. The analysis of urine sample revealed leucocyturia and Escherichia coli grew on urine culture. Therapy with erythromycin, which was found to be sensitive against both pathogens, and also the main therapeutic agent for PLEVA started 250mg tb 4x1 orally, since the histopathological findings were also compatible with PLEVA. A rapid response was achieved and more than half of the lesions were found to be regressed in ten days. In this report, a child of PLEVA with a rapid and dramatic response to erythromycin therapy is described with a brief literature review.

  4. Higher Expression of Toll-like Receptors 3, 7, 8, and 9 in Pityriasis Rosea

    Science.gov (United States)

    El-Ela, Mostafa Abou; El-Komy, Mohamed; Hay, Rania Abdel; Hegazy, Rehab; Sharobim, Amin; Rashed, Laila; Amr, Khalda

    2017-01-01

    Background Pityriasis rosea (PR) is a common papulosquamous skin disease in which an infective agent may be implicated. Toll-like receptors (TLRs) play an important role in immune responses and in the pathophysiology of inflammatory skin diseases. Our aim was to determine the possible roles of TLRs 3, 7, 8, and 9 in the pathogenesis of PR. Methods Twenty-four PR patients and 24 healthy individuals (as controls) were included in this case control study. All recruits were subjected to routine laboratory investigations. Biopsies were obtained from one active PR lesion and from healthy skin of controls for the detection of TLR 3, 7, 8, and 9 gene expression using real-time polymerase chain reaction. Results This study included 24 patients (8 females and 16 males) with active PR lesions, with a mean age of 28.62 years. Twenty four healthy age- and sex-matched individuals were included as controls (8 females and 16 males, with a mean age of 30.83 years). The results of the routine laboratory tests revealed no significant differences between both groups. Significantly elevated expression of all studied TLRs were detected in PR patients relative to healthy controls (p < .001). Conclusions TLRs 3, 7, 8, and 9 might be involved in the pathogenesis of PR. PMID:28192646

  5. Efficacy of 308-nm xenon chloride excimer laser in pityriasis alba.

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    Al-Mutairi, Nawaf; Hadad, Ahmed Al

    2012-04-01

    Pityriasis alba (PA) is the most common cause of facial hypopigmentation presenting to the dermatologist. The objective of the current study was to study the effect of the 308-nm excimer laser in the treatment of PA. Twelve patients with 37 PA patches were enrolled in this study. The lesions were treated using the 308-nm excimer laser twice a week for 12 weeks. The hypopigmented areas were evaluated at baseline and at weeks 0, 3, 6, and 12 for scaling, hypopigmentation, and pruritus on a 4-point scale (0 = none to 3 = severe). All adverse effects were recorded. There were seven male and five female participants in (aged 5-21 years), with skin type III to V. After 1 month of laser therapy, the clinical scores were significantly lower than at baseline. Similar decreases were observed for the scaling and pruritus scores. Uneven skin color improved by the third week, and near-complete resolution was noticed by the end of 3 months. No serious or unpleasant side-effects were observed, and all patients completed the 12-week treatment. Patients were satisfied or very satisfied with the treatment. The 308-nm excimer laser is an effective therapeutic option for PA. © 2011 by the American Society for Dermatologic Surgery, Inc. Published by Wiley Periodicals, Inc.

  6. Familial pityriasis rubra pilaris is caused by mutations in CARD14.

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    Fuchs-Telem, Dana; Sarig, Ofer; van Steensel, Maurice A M; Isakov, Ofer; Israeli, Shirli; Nousbeck, Janna; Richard, Katharina; Winnepenninckx, Veronique; Vernooij, Marigje; Shomron, Noam; Uitto, Jouni; Fleckman, Philip; Richard, Gabriele; Sprecher, Eli

    2012-07-13

    Pityriasis rubra pilaris (PRP) is a papulosquamous disorder phenotypically related to psoriasis. The disease has been occasionally shown to be inherited in an autosomal-dominant fashion. To identify the genetic cause of familial PRP, we ascertained four unrelated families affected by autosomal-dominant PRP. We initially mapped PRP to 17q25.3, a region overlapping with psoriasis susceptibility locus 2 (PSORS2 [MIM 602723]). Using a combination of linkage analysis followed by targeted whole-exome sequencing and candidate-gene screening, we identified three different heterozygous mutations in CARD14, which encodes caspase recruitment domain family, member 14. CARD14 was found to be specifically expressed in the skin. CARD14 is a known activator of nuclear factor kappa B signaling, which has been implicated in inflammatory disorders. Accordingly, CARD14 levels were increased, and p65 was found to be activated in the skin of PRP-affected individuals. The present data demonstrate that autosomal-dominant PRP is allelic to familial psoriasis, which was recently shown to also be caused by mutations in CARD14. Copyright © 2012 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

  7. Atypical pityriasis rosea: a case report and a review of literature

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    Iqbal A. Bukhari

    2015-02-01

    Full Text Available Aim: Pityriasis rosea (PR is a common acute inflammatory skin disease characterized by pruritic erythematous papulosquamous eruption that is self-limited which can rarely pose a diagnostic challenge. In this report, we present a rare presentation of PR.Method: the case was completely evaluated including laboratory works and a final diagnosis of erythema multiforme-like PR was reached. Besides, we reviewed all atypical presentations of PR that are reported in the medical literature.Results: our patient has a morphological variant of PR which is erythema multiforme-like. The presence of a herald patch and  the rapid resolution of the symptoms supports our diagnosis. This variant is considered rare and to our knowledge, this is the seventh case of erythema multiforme-like PR reported in the medical literature.In conclusion: we report a case of erythema multiforme-like PR. It is important that physicians recognize the wide spectrum of PR variants so that appropriate management can be arranged. 

  8. Pityriasis versicolor during anti-TNF-α monoclonal antibody therapy: therapeutic considerations.

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    Balestri, Riccardo; Rech, Giulia; Piraccini, Bianca Maria; Antonucci, Angela; Ismaili, Alma; Patrizi, Annalisa; Bardazzi, Federico

    2012-09-01

    Anecdotal reports have shown that tumour necrosis factor (TNF)-α inhibition may cause unchecked superficial infection with the microorganisms responsible for pityriasis versicolor (PV). We observed several cases of PV, which is frequently resistant to topical therapies, in psoriatic patients undergoing anti-TNF-α monoclonal antibody therapy. To evaluate the incidence and the therapeutic management of PV in this group of individuals, between 1 January and 27 December 2010, we examined 153 psoriatic patients for the hypopigmented/hyperpigmented macular and scaling lesions associated with PV. All patients positive for PV were given topical therapy with miconazole nitrate cream twice daily for 28 days, after which they were re-evaluated. In patients non-responsive to topical therapy, we started systemic therapy with fluconazole, 300 mg week(-1) for 3 weeks. We diagnosed seven cases of PV. At the end of topical treatment, complete healing of lesions was observed in only one patient. In the other six patients, systemic treatment led to complete resolution of the infection. Although the onset of PV during anti-TNF-α therapy is seldom reported, it is not likely to be rare, but rather under-reported because of its limited pathological significance. In our opinion, the therapeutic management of this condition deserves greater consideration, as the use of topical treatments alone is largely ineffective compared with systemic treatment.

  9. [Ultrastructure of parapsoriasis lesions. Parapsoriasis en plaques and parakeratosis variegata as prelymphoma; differences from pityriasis lichenoides].

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    Orfanos, C E; Tsambaos, D

    1982-08-15

    The morphological alterations of involved skin in three different types of parapsoriasis were investigated in 9 patients by electron microscopy. Pityriasis lichenoides chronica (PLC) is characterized by a lymphohistiocytic dermal infiltrate and by epidermotropic histiocytic cells, which penetrate up to the horny layer. In parapsoriasis en plaques (PeP) and in parakeratosis variegata (PV) the dermal infiltrate is mainly composed of lymphocytoid cells, some of which, particularly in PV, reveal the features of Sézary-Cells (11% and 30% respectively). The epidermis is predominantly invaded by partly atypical lymphoid cells. In some instances membrane contacts between Langerhans cells, keratinocytes and atypical lymphoid cells can be observed. The increased number of epidermotropic cells and the increase of atypical lymphoid cells in the dermal infiltrate are the main ultrastructural features of the malignant transformation of PV. Finally, an important difference between PLC and the other two types of parapsoriasis is the fact that in PLC epidermotropic cells are mostly of histiocytic origin, whereas in PeP and PV they are mainly lymphocytes. The electron microscopic findings support the opinion that PLC should not be considered as a type of parapsoriasis and that PeP and PV probably correspond to prelymphoma.

  10. New-onset vitiligo during long-term, stable infliximab treatment of pityriasis rubra pilaris.

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    Mattox, Adam R; Chappell, Jeaneen A; Hurley, M Yadira

    2013-02-01

    Incidents of new-onset vitiligo attributed to infliximab therapy for rheumatoid arthritis and ulcerative colitis have been reported. Reported cases share a common theme in that symptoms manifested in close proximity to the initiation or significant dose increase of the medication. This case describes the presentation of infliximab-induced vitiligo in a patient using it for long-term treatment of stable pityriasis rubra pilaris. The patient was initiated and titrated to a stable dose of infliximab totaling 27 months' duration. He was able to achieve near-complete resolution of symptoms before developing depigmented patches consistent with vitiligo. Infliximab was discontinued. Tacrolimus 0.1% ointment and narrow-band ultraviolet B light successfully repigmented the patches. The association of discontinuing infliximab and resolution of vitiligo suggests infliximab had a role in this case. Though the mechanism of involvement is undetermined, infliximab may have induced an autoimmune process by paradoxically activating lymphocytes. Alternatively, infliximab antibodies may have led to the process by disrupting the normal balance of cytokines.

  11. Pityriasis rosea: a natural history of pediatric cases in theCentral Anatolia Region of Turkey.

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    Çölgeçen, Emine; Kader, Çiğdem; Ulaş, Yılmaz; Öztürk, Pınar; Küçük, Öznur; Balcı, Mehmet

    2016-12-20

    This study aimed to evaluate the demographic, clinical, and epidemiological features of pityriasis rosea (PR) in a cohort of 46 children in Yozgat, a city in the Central Anatolia Region of Turkey. Forty-six children with PR were monitored at regular intervals (1, 2, 4, and 12 weeks) for 3 months from the time of diagnosis. A complete evaluation of the patient was performed at each visit. The average age of patients at time of diagnosis was 12 ± 3.9 years. Cases were most common in the winter (rainy, snowy months; n = 14, 31%). Fifteen patients had a medical history significant for the presence of upper respiratory tract infection, while skin PR manifestations were preceded by drug intake in a second group of 15 patients. The presence of a herald patch was observed in 78.3% of patients, most frequently on the trunk (n = 23). Pruritus occurred in 75% of patients. Median PR duration was 3 weeks (range: 1-20 weeks). The course of PR is similar in Turkish children and adults. The high prevalence of pruritus in children with PR in Turkey was also significant. Further evaluation of this finding comparing adults and children is now required.

  12. Pityriasis Lichenoides-like Mycosis Fungoides: Clinical and Histologic Features and Response to Phototherapy

    Science.gov (United States)

    Jang, Min Soo; Kang, Dong Young; Park, Jong Bin; Kim, Joon Hee; Park, Kwi Ae; Rim, Hark

    2016-01-01

    Background Pityriasis lichenoides (PL)-like skin lesions rarely appear as a specific manifestation of mycosis fungoides (MF). Objective We investigated the clinicopathological features, immunophenotypes, and treatments of PL-like MF. Methods This study included 15 patients with PL-like lesions selected from a population of 316 patients diagnosed with MF at one institution. Results The patients were between 4 and 59 years of age. Four patients were older than 20 years of age. All of the patients had early-stage MF. In all patients, the atypical lymphocytic infiltrate had a perivascular distribution with epidermotropism. The CD4/CD8 ratio was <1 in 12 patients. Thirteen patients were treated with either narrowband ultraviolet B (NBUVB) or psoralen+ultraviolet A (PUVA), and all of them had complete responses. Conclusion PL-like MF appears to have a favorable prognosis and occurrence of this variant in adults is uncommon. MF should be suspected in the case of a PL-like skin eruption. Therefore, biopsy is required to confirm the diagnosis of PL-like MF, and NBUVB is a clinically effective treatment. PMID:27746631

  13. Anesthetic Considerations for Neuraxial Anesthesia in Pregnant Patients With Pityriasis Rosea With Skin Lesions Covering the Lumbar Spine.

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    Werntz, Megan; Chun, Carlene; Togioka, Brandon Michael

    2016-10-15

    Pityriasis rosea (PR) is an acute exanthematous skin disease that is likely due to reactivation of human herpesviruses (HHVs) 6b and 7. In contrast to herpes simplex and zoster (alphaherpesviruses), HHV-6b and -7 (betaherpesviruses) are not found predominantly in skin lesions. This difference in virion location may decrease the possibility of causing central nervous system infection through skin contamination, but the risk for hematogenous spread likely remains the same. This article uses the first-known epidural placement through active PR to illustrate risk-benefit considerations when deciding between neuraxial and general anesthesia for obstetric patients with PR.

  14. A double-blind comparison of 2% ketoconazole and 1% clotrimazole in the treatment of pityriasis versicolor

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    Balwada R

    1996-01-01

    Full Text Available Forty adult patients of pityriasis versicolor were treated with either topical 2% ketoconazole cream (20 patients or topical 1% clotrimazole cream (20 patients. In global assessment of treatment after 2 weeks, 18 (90% out of 20 patients treated with ketoconazole cream were cured while 2 cases had considerable residual lesions. In clotrimazole treated group, 17 (85% out of 20 patients were cured and 3 still had considerable lesions. No significant difference was observed in response rates in the two groups. No side effects were reported in either groups.

  15. Successful treatment of pityriasis lichenoides chronica with narrow-band ultraviolet B therapy in a patient with Keratitis-Ichthyosis-Deafness syndrome: a case report.

    Science.gov (United States)

    Salman, Andac; Gencosmanoglu, Dilek Seckin; Yucelten, Ayse Deniz; Elcioglu, Nursel; Richard, Gabriele; Demirkesen, Cuyan

    2016-05-15

    Keratitis-ichthyosis-deafness (KID) syndrome is a rare genodermatosis causing ichthyosis-like skin lesions, keratitis, and deafness. Herein, we report a patient with this rare syndrome in association with pityriasis lichenoides chronica, which was succesfully treated with narrow-band ultraviolet B phototherapy despite our concerns regarding the increased risk of squamous cell carcinoma, hyperpyrexia, and keratitis.

  16. Epidemiological Characters of Pityriasis Versicolor and Erythrasma among Admitted Patients of Medical Mycology Lab of Kermanshah University of Medical Sciences 1994 -2011

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    Mikaeili, A. (PhD

    2014-05-01

    Full Text Available Background and Objective: The rate of superficial mycoses are increasing in special conditions. This retrospective study was conducted to determine the epidemiological parameters of Pityriasis versicolor and Erythrasma during 1994- 2011. Material and Methods: In this study, we assessed the results of direct microscopic study and the other data of the patients for Pityriasis versicolor and Erythrasma in 1994-2011. Results: Of 2265, 1294 (57% suffered from pityriasis versicolor, who were mostly males (60%. The highest frequency was related to 20-29 year old and the lowest to 0-9. High school and university students were the most infected groups (33%, September was the most common period and the most common site of involvement was chest and abdomen. The people infected with Erythrasma (971; 42%, were mostly 30 -39 year old , males( 58% , urban ( 98% , reported in July and involved in groin. Conclusion: The frequency of both diseases was high in active age group, males, and the hot months of the year, which are the most common predisposing factors. Keywords: Pityriasis Versicolor; Erythrasma; Kermanshah

  17. CLINICAL EVALUATION OF EFFICACY OF SERTACONAZOLE 2% CREAM IN TREATMENT OF PITYRIASIS VERSICOLOR AND A COMPARISION WITH THAT OF CLOTRIMAZOLE 1% CREAM

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    Lakshmi Tatavarthi

    2015-04-01

    Full Text Available BACKGROUND: Pityriasis versicolor is a mild superficial, chronic recurrent fungal infection. Many topical agents have been used with varying degree of success and high recurrence rate. The current study was conducted to clinically evaluate the efficacy of sertaconazole 2% in treating and preventing recurrences of pityriasis versicolor as compared to clotrimazole1%cream. AIMS: Clinical evaluation of the efficacy of sertaconazole 2% cream in the treatment of pityriasis versicolor and its comparison with that of clotrimazole 1% cream. MATERIALS & METHODS: 110 patients who were diagnosed clinically and microscopically as pityriasis versicolor and fulfilling the criteria were enrolled, of which 55 were treated with 2% sertaconazole cream and 55 with 1% clotrimazole cream twice daily for 4 weeks. At the end of fourth week patients were examined both clinically and mycologically. Follow up was done at 6 weeks to note any relapse clinically and mycologically. RESULTS : Out of 110 patients 4 patients using sertaconazole, 6 patients using clotri mazole were lost for follow - up and excluded from the study. Global assessment was done at the end of treatment i.e., 4 weeks with clinical and mycological cure rate, revealed that 42(82.3% of the sertaconazole group, 30(61.2% of the clotrimazole group we re improved clinically. Mycological examination at the same time was negative in 44(86.3%, 33(67.4% respectively. 7(13.7% of sertaconazole group, 12(24.48% of clotrimazole group show no significant change. 4(8.16% patients using clotrimazole complaine d of deterioration of symptoms but none using sertaconazole. CONCLUSION : Comparing the results obtained in this trial showed that sertaconazole was more efficacious than clotrimazole in the treatment of pityriasis versicolor because of its direct membrane damaging effect. But in terms of pigmentary resolution sertaconazole is not comparable to clotrimazole cream due to persistent effect of azelic acid.

  18. Single-dose oral fluconazole versus topical clotrimazole in patients with pityriasis versicolor: A double-blind randomized controlled trial.

    Science.gov (United States)

    Dehghan, Mohammad; Akbari, Negin; Alborzi, Nazila; Sadani, Somayeh; Keshtkar, Abas A

    2010-08-01

    This study was designed to compare the therapeutic effects of topical clotrimazole and systemic fluconazole in pityriasis versicolor. A double-blind randomized controlled trial was carried out in the dermatological clinic of Gorgan, northern Iran, between April 2006 and May 2007. All consecutive patients with pityriasis versicolor were included and randomly divided into two groups. In the first group (G1), patients underwent treatment with a single dose of fluconazole capsule (400 mg) and placebo cream. In the second group (G2), patients underwent treatment with clotrimazole cream (twice daily) and placebo capsule. The course of treatment was 2 weeks. All subjects were re-evaluated 2, 4 and 12 weeks after the end of the therapeutic course. After 2 weeks, the rate of complete resolution of disease was significantly higher in G2 than G1 (49.1% vs 30%). After 4 weeks, 41 patients (81.2%) of G1 and 52 patients (94.9%) of G2 showed complete resolution. After 12 weeks, 46 patients (92%) in G1 and 45 patients (81.8%) in G2 showed complete resolution. Recurrence rate in G1 and G2 were 6% and 18.2%, respectively. No complications were seen in either group. In this study, clinical response at week 4 was greater in the clotrimazole group than the fluconazole group. Recurrence at week 12 after treatment was less with oral fluconazole than clotrimazole cream. So, for better evaluation, more studies need to be done.

  19. Adult pityriasis lichenoides-like mycosis fungoides: a clinical variant of mycosis fungoides.

    Science.gov (United States)

    de Unamuno Bustos, Blanca; Ferriols, Amparo P; Sánchez, Rosa B; Rabasco, Ana G; Vela, Carmen G; Piris, Miguel A; Alegre de Míquel, Víctor

    2014-11-01

    Mycosis fungoides (MF) is the most frequent type of cutaneous T cell lymphoma. Its clinicopathological spectrum is wide, and the resulting diversity makes it difficult to establish a differential diagnosis among pityriasis lichenoides (PL), lymphomatoid papulosis (LyP), and atypical MF. This study describes four patients with longstanding PL-like lesions, in whom clinicopathological correlations contributed towards the establishment of definitive diagnoses of MF. The clinical histories of the four patients were reviewed. Skin biopsies were processed by hematoxylin and eosin staining and immunohistochemical techniques. Disease spread was studied according to laboratory tests, complete blood counts, biochemical parameters, lactate dehydrogenase, lymphocyte populations, and Sézary cells. Thoracoabdominopelvic computed tomography was performed. The four patients included two women and two men, aged 35-70 years, all of whom had chronic skin lesions located mainly on the trunk and extremities. In three patients, initial clinicopathological correlations led to the diagnosis of PL; further biopsies were required to diagnose MF. In all patients, the atypical lymphocytic infiltrate showed a lichenoid or perivascular distribution with focal epidermotropism and parakeratosis. All cases proved positive for CD4 and CD3, and negative for CD20, CD8, and CD30. Polymerase chain reaction showed monoclonal-type T cells in one and polyclonal infiltrates in three patients. All patients were initially treated with topical corticosteroids and photochemotherapy. None of the treatments proved completely successful, but subsequent tests have yielded no evidence of disease progression in any patient. In patients with clinical features of longstanding PL and histological findings consistent with MF, differential diagnosis must include PL, LyP, and papular MF. As some forms of PL evolve towards MF and PL-like forms of MF, these patients should undergo regular follow-up and repeated biopsies

  20. Evaluation of pityriasis versicolor in prisoners: A cross-sectional study

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    Salahi-Moghaddam Abdoreza

    2009-01-01

    Full Text Available Background: Pityriasis versicolor (PV is a mild but recurrent superficial fungal infection of stratum corneum. Many predisposing factors such as late teen and young adulthood age, tropical and subtropical climate (and to a lesser extent temperate climate, immunosuppression, malnutrition, use of oral contraceptives, hyperhidrosis, poor hygiene and a few other factors have been proposed for this condition. Aim: Regarding these probable and possible risk factors, we felt that jail is a unique population which can be affected by this infection and therefore we decided to evaluate some aspects of this infection in this population. Methods: In this cross-sectional study in male prisoners of Bandarabbas city, 230 prisoners were randomly selected. One hundred and five (45.67% of them were diagnosed to be infected. They were also evaluated regarding age, duration of being imprisoned, skin color, site of lesion and its pigmentation change and any concomitant clinical manifestation such as pruritis, burning or cebure. Chi-square test or Fisher′s exact test was used for data analysis. Results: Mean age of infected population was 31.62 ± 8.67 years while peak incidence of PV was in 28-32 years age group. The most common color change was hypopigmentation. No case of PV hyperpigmentation was seen. We could not also observe any association between skin color and duration of being imprisoned with the frequency of infection. Conclusion: There seems to be no difference between pattern of infection in the general population and prisoners′ population in the aspects evaluated.

  1. 萎缩性花斑糠疹%Atrophying pityriasis versicolor

    Institute of Scientific and Technical Information of China (English)

    胡燕; 朱小红; 陈浩; 张海平; 吉津; 杨莉佳

    2013-01-01

    A 26-year-old woman presented with scaly atrophic erythema on the chest and abdomen for nearly 2 years.Direct microscopic examination of the lesion scrapings revealed numerous stubby hyphae and clustered spores.Periodic acid-Schiff (PAS) staining of the biopsy tissue showed the presence of numerous hyphae and spores in the horny layer.The stain for elastic fibers revealed that the number of elastic fibers decreased,and some elastic fibers became fine and disrupted.The patient was diagnosed with atrophying pityriasis versicolor.The lesions subsided and direct microscopic examination was negative after 1-week treatment with oral itraconazole of 200 mg once daily and 4-week treatment with topical 2% sertaconazole cream.%患者女,26岁.因胸腹部鳞屑性红斑伴萎缩近2年就诊.取皮屑直接镜检,见较多粗短的菌丝及成簇孢子.皮损组织病理检查,过碘酸雪夫(PAS)染色见角质层内较多菌丝和孢子.弹力纤维染色示弹力纤维减少,部分弹力纤维纤细、断裂.诊断:萎缩性花斑糠疹.治疗:口服伊曲康唑胶囊200mg/d共1周,外用2%舍他康唑乳膏4周,皮疹消退,真菌直接镜检复查阴性.

  2. Identification of Malassezia species from pityriasis versicolor lesions with a new multiplex PCR method.

    Science.gov (United States)

    Vuran, Emre; Karaarslan, Aydın; Karasartova, Djursun; Turegun, Buse; Sahin, Fikret

    2014-02-01

    Despite the fact that a range of molecular methods have been developed as tools for the diagnosis of Malassezia species, there are several drawbacks associated with them, such as inefficiency of differentiating all the species, high cost, and questionable reproducibility. In addition, most of the molecular methods require cultivation to enhance sensitivity. Therefore, alternative methods eliminating cultivation and capable of identifying species with high accuracy and reliability are needed. Herein, a multiplex polymerase chain reaction (PCR)-based method was especially developed for the detection of eleven Malassezia species. The multiplex PCR was standardized by incorporating a consensus forward primer, along with Malassezia species-specific reverse primers considering the sizes of the PCR products. In the method, the multiplex-PCR primer content is divided into three parts to circumvent the problem of increased nonspecific background resulting from the use of a large number of primers. DNA extraction protocol described by Harju and colleagues was modified using liquid nitrogen instead of -80 °C to break down the yeast membrane. By a modified extraction procedure followed by multiplex PCR and electrophoresis, the method enables identification and differentiation of Malassezia species from both of the samples obtained directly from skin and yeast colonies grown in culture. Fifty-five patients who were confirmed with pityriasis versicolor were enrolled in the study. Multiplex PCR detected and differentiated all 55 samples obtained directly from the patients' skin. However, 50 out of 55 samples yielded Malassezia colony in the culture. In addition, eight of 50 colonies were misdiagnosed or not completely differentiated by conventional methods based on the sequence analysis of eight colonies. The method is capable of identifying species with high accuracy and reliability. In addition, it is simple, quick, and cost-effective. More importantly, the method works

  3. Pityriasis lichenoides chronica%慢性苔藓样糠疹

    Institute of Scientific and Technical Information of China (English)

    尹晓慧; 张艳; 曲晓滨; 邢庆涛

    2014-01-01

    Pityriasis lichenoides chronica (PLC) is a papulosquamous dermatosis with unknown etiology.It usually occurs in children and youth,occasionally in neonates and the elderly,and more frequently in females than in males.There are three main hypotheses on its pathogenesis,namely,infection theory,lymphocyte proliferation theory and immune complex deposition theory.Histopathological manifestations of PLC are not specific.Some novel ideas are introduced in this article for the treatment of PLC.In addition to traditional systemic antibiotics,topical corticosteroids and photochemotherapy,methotrexate,cyclosporine,dapsone and acitretin also have good therapeutic effects on PLC.%慢性苔藓样糠疹是一种病因不明的丘疹鳞屑性皮肤病,儿童和青年人好发,偶见于新生儿和老人,女性发病高于男性.该病的发病机制主要有3种假说,感染学说、淋巴细胞增殖学说、免疫复合物沉积学说.慢性苔藓样糠疹的组织病理无特异性.对慢性苔藓样糠疹的治疗提供了一些新观点,除系统应用抗生素、局部外用糖皮质激素及光化学疗法外,甲氨蝶呤、环孢素、氨苯砜和阿维A等对慢性苔藓样糠疹也有较好的疗效.

  4. Novos aspectos na evolução clínica da pitiríase versicolor New aspects in the clinical course of pityriasis versicolor

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    Valéria Maria de Souza Framil

    2011-12-01

    Full Text Available FUNDAMENTO: A pitiríase versicolor é uma doença infecciosa causada por várias espécies de Malassezia com uma tendência a se tornar recidivante ou crônica. OBJETIVOS: Este trabalho foi conduzido na tentativa de conhecer a evolução clínica da pitiríase versicolor em relação ao número de recidivas após um tratamento adequado no período de 12 meses e correlacionar o número de recidivas com as espécies de Malassezia isoladas. MATERIAL E MÉTODOS: Cento e dois pacientes com diagnóstico clínico e laboratorial de pitiríase versicolor foram acompanhados por um período de 12 meses para observarmos o número de recidivas da doença. RESULTADOS: A pitiríase versicolor, após um tratamento adequado, apresentou três tipos de evolução clínica num período de 12 meses: pitiríase versicolor sem nenhum episódio de recidiva (32,35%; pitiríase versicolor recidivante, com um a quatro episódios de recidiva (52,94% devidos a fatores de predisposição relacionados; e pitiríase versicolor crônica, com mais de quatro episódios de recidiva (14,70% sem nenhuma relação com fatores de predisposição. CONCLUSÕES: A pitiríase versicolor apresentou uma evolução clínica de acordo com o número de episódios de recidiva da doença analisados durante um período de 12 meses que pode ser considerada da seguinte maneira: pitiríase versicolor com cura clínica e micológica, pitiríase versicolor recidivante e pitiríase versicolor crônica.BACKGROUND: Pytiriasis versicolor is an infectious disease caused by several Malassezia species which has a tendency to become relapsing or chronic. OBJECTIVES: This study was conducted in an attempt to investigate the clinical course of pityriasis versicolor with regard to the number of relapses after a 12-month therapy and correlate this number with isolates of Malassezia species. MATERIAL AND METHODS: 102 patients with clinical and laboratory diagnosis of pityriasis versicolor were monitored for 12

  5. Interleukin 23-Helper T Cell 17 Axis as a Treatment Target for Pityriasis Rubra Pilaris.

    Science.gov (United States)

    Feldmeyer, Laurence; Mylonas, Alessio; Demaria, Olivier; Mennella, Anna; Yawalkar, Nikhil; Laffitte, Emmanuel; Hohl, Daniel; Gilliet, Michel; Conrad, Curdin

    2017-04-01

    Treatment of pityriasis rubra pilaris (PRP) is solely based on its resemblance to psoriasis rather than any knowledge of its pathomechanism. Insight into pathogenic mediators of inflammation is essential for targeted and valid treatment options that could replace previous serendipitous therapeutic approaches in refractory PRP. To determine whether blockade of the interleukin 23-helper T cell 17 (IL-23-TH17) pathway with ustekinumab represents an efficacious and, based on its proinflammatory cytokine profile, targeted treatment option in PRP. In this case report, a patient with PRP received outpatient treatment at a university hospital department of dermatology with ustekinumab according to the dosing regimen approved for psoriasis. Lesional skin biopsy samples were taken from this patient and 2 others with refractory PRP. Messenger RNA (mRNA) expression of proinflammatory innate and T-cell-derived cytokines were measured and compared with skin samples from patients with psoriasis and healthy donors. From 1 patient, lesional skin samples were taken before ustekinumab treatment and 4 and 28 weeks after treatment initiation. Follow-up was completed after 6 months. Subcutaneous ustekinumab, 45 mg, at weeks 0 and 4 and quarterly thereafter. The primary outcome was to determine the changes in expression of proinflammatory innate and T-cell-derived cytokines during ustekinumab therapy. The secondary objective was to evaluate the clinical and histopathologic phenotype in relation to the mRNA expression profile of proinflammatory cytokines. In lesional PRP skin samples from a single patient, upregulated expression levels were found for most proinflammatory innate cytokines, including tumor necrosis factor (TNF), IL-6, IL-12, IL-23, and IL-1β. Among adaptive T-cell cytokines, an increase of TH1 cytokines and, in particular, TH17 cytokines IL-17A, IL-17F, and IL-22 was seen in PRP. The patient with PRP who received ustekinumab showed regression of skin lesions after 2 weeks

  6. To treat or not to treat? Management of guttate psoriasis and pityriasis rosea in patients with evidence of group A Streptococcal infection.

    Science.gov (United States)

    Krishnamurthy, Karthik; Walker, Ashley; Gropper, Charles A; Hoffman, Cindy

    2010-03-01

    The association between guttate psoriasis and pityriasis rosea with Streptococcus pyogenes (S. pyogenes) is well established in the literature; however treatment guidelines and necessity have not been clarified with respect to the infectious etiology. Also, the exact role of Streptococcus in the immunopathogenesis of these entities, and the associated risk of development of scarlet fever and poststreptococcal sequelae, are not centrally reported. No single report or case series definitively establishes the coexistence between guttate psoriasis and post-streptococcal sequelae in the same patient, supporting the theories of autoimmune protection conferred between these entities. Laboratory investigations and treatment of Streptococcus in the setting of guttate psoriasis are not necessary, as anti-streptococcal treatment does not significantly modify the course of cutaneous disease, and there is no theoretical or documented risk of post-streptococcal sequelae. However, due to minimal data, antibiotics may still have a role in pityriasis rosea.

  7. Cell-mediated immune responses to Malassezia furfur serovars A, B and C in patients with pityriasis versicolor, seborrheic dermatitis and controls.

    Science.gov (United States)

    Ashbee, H R; Ingham, E; Holland, K T; Cunliffe, W J

    1994-06-01

    It has been postulated that patients with Malassezia furfur-associated dermatoses have a deficient cell-mediated immune response to M. furfur. This study examined the cell-mediated immune responses to M. furfur serovars A, B and C of 10 patients with pityriasis versicolor and 10 age- and sex-matched controls; and 10 patients with seborrheic dermatitis and 10 age- and sex-matched controls. The responses to each serovar of M. furfur were assessed using the lymphocyte transformation assay and the leukocyte migration inhibition assay. The lymphocyte transformation responses of the patients with pityriasis versicolor to M. furfur serovars A, B and C (0/10, 6/10 and 5/10 respectively) were not significantly different from those of controls (0/10, 2/10 and 1/10). However, for patients with seborrheic dermatitis, significantly more patients' lymphocytes responded to serovars B and C (6/10 and 6/10 respectively) than those of controls (1/10 and 1/10). No patient or control responded to serovar A. In the leukocyte migration inhibition assay, the leukocytes from a greater proportion of patients with pityriasis versicolor (5/7) responded to serovar B than controls (2/10); and the leukocytes from a greater proportion of patients with seborrheic dermatitis (4/10) responded to serovar C than controls (0/9). Thus, this data did not indicate the presence of any cell-mediated immune deficiency to M. furfur in patients with pityriasis versicolor or seborrheic dermatitis, as measured by the lymphocyte transformation assay or the leukocyte migration inhibition assay. The greater responsiveness of T lymphocytes from patients may indicate that T lymphocytes might be involved in the pathogenesis of these diseases.

  8. The prevalence of pityriasis versicolor in the dormitories of the Lorestan University of Medical Sciences by the three methods: skin scraping, use of scotch tape and wood’s lamp

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    sanaz Rostami

    2016-05-01

    Full Text Available Background : Pityriasis versicolor is a chronic, recurrent and often asymptomatic infection of stratum corneum, Which is caused by lipophilic yeasts of Malassezia. Human to human transmission through direct contact is possible. The present study aimed to assess the prevalence of pityriasis versicolor in the dormitories of the Lorestan University of Medical Sciences by the three methods: skin scraping, use of scotch tape and wood’s lamp was perfumed. Materials and Methods: In this descriptive cross-sectional study,115 students in the dormitories of the university of medical sciences were studied with the three methods:skin scraping, using  scotch tape and wood’s lamp. Results: Among 115 patients, 66.94% were female and 33.05% were male. The mean age was 21.38 years.25% of boys and 11.1% of girls were affected.The prevalence of  Pityriasis versicolor by  the three methods was determined 15.7%. In this study, the  most common site of infection was shoulder and neck. Conclusion: The recent study showed a high prevalence of Pityriasis versicolor in Lorestan University of  Medical Sciences students . The prevalence of pityriasis versicolor had a statistically significant difference between males and females, and was more common in females .  The pairwise comparison results obtained  from the three methods using the Kappa coefficient, scotch tape method  was the most consistent results than the other two methods.

  9. The Use of Synchrotron Infrared Microspectroscopy in the Assessment of Cutaneous T-cell Lymphoma vs. Pityriasis lichenoides Chronica

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    El Bedewi, A.; El Anany, G; El Mofty, M; Kretlow, A; Park, S; Miller, L

    2010-01-01

    The diagnosis of cutaneous lymphomas remains a challenge for both the clinician and dermatopathologist. To differentiate between frank malignant and premalignant lymphocytes within the skin. This study was performed on 20 patients with a mean age of 50 years. They were divided into two groups: mycosis fungoides (MF) (stage IA, IB and IIA) and pityriasis lichenoides chronica (PLC). Immunophenotyping using antibodies CD3, CD4, CD8, CD20 and CD30 was performed. Synchrotron Fourier transform infrared microspectroscopy (S-FTIRM) was performed on cell nuclei to assess chemical differences between MF and PLC cases as a potential complementary screening tool. Dermal spectra of both MF and PLC were compared using principal components analysis (PCA) of the S-FTIRM data. All PLC spectra was clustered together. However, the MF spectra formed two clusters, one that grouped with the PLC and the other grouped separately. Moreover, protein and nucleic acids showed highly significant differences between MF (IIA and IB), MF (IA) and PLC. The malignant transformation within lymphocytes was identifiable through the spectroscopic analysis of protein, RNA and DNA with S-FTIRM, making it a promising tool for classifying the progression of cutaneous T-cell lymphoma.

  10. Study of the distribution of Malassezia species in patients with pityriasis versicolor and healthy individuals in Tertiary Care Hospital, Punjab

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    M Kaur

    2013-01-01

    Full Text Available Purpose: Pityriasis versicolor (PV is a chronic superficial fungal disease caused by Malassezia species. Our aim was to identify Malassezia species from PV patients and healthy individuals in Punjab. Materials and Methods: Modified Dixon agar was used as isolation culture medium. Identification was based on morphological observation and biochemical evaluation. The biochemical evaluation consisted of culture onto Sabouraud dextrose agar, catalase reaction, Tween assimilation, Cremophor EL assimilation, splitting of esculin and growth at 38 0 C. Results: Out of 58 microscopically diagnosed cases of PV, growth was obtained from 54 (93.10% cases. The most frequently isolated species were M. globosa, M. sympodialis and M. furfur which made up 51.79%, 31.42% and 18.51% of the isolated etiological agents respectively. However, the major isolate from the back of healthy individuals was M. sympodialis (47.61%, followed by M.obtusa (19.04%, M. globosa (14.20%, M. furfur (9.52%, M. pachydermatis (4.76% and M. slooffiae (4.76%. Conclusions: M. globosa in its mycelial phase was the main etiological agent, but as normal flora from the back of healthy subjects, it was found in significantly less number (P = 0.01, suggesting that the higher pathogenicity of M. globosa in terms of enzymatic endowment, might be the cause of its predominance in PV lesions.

  11. An Analysis of the Malassezia Species Distribution in the Skin of Patients with Pityriasis Versicolor in Chengdu, China

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    Zhen Xie

    2014-01-01

    Full Text Available Pityriasis versicolor (PV is a common clinical problem associated with Malassezia species (Malassezia spp.. Controversies remain regarding the specific species involved in the development of PV. This study analyzed the difference in Malassezia spp. distribution in lesional and nonlesional skin in Chinese PV patients. A paired design was applied. Lesional and nonlesional scales from 24 cases were collected; real-time fluorescence quantitative PCR was used to detect 10 different Malassezia spp. In lesional skin, the highest detection rates were for M. globosa (95.8%, M. restricta (91.7%, and M. sympodialis (50.0%. In nonlesional skin, the highest detection rates were for M. globosa (87.5%, M. restricta (79.2%, and M. dermatis (33.3%. A significant difference in the detection rate was only found for M. sympodialis (50.8% versus 20.8%, P=0.04. Compared with nonlesional skin, the amount of M. globosa, M. restricta, and M. sympodialis in lesional skin was significantly higher (3.8±1.3,   2.5±1.1, and 3.2±1.6 times higher, resp.. The results of this study do not indicate that M. globosa and M. restricta are directly correlated with PV development; however, M. sympodialis is more likely related to PV development in Chinese individuals.

  12. Severe, Disfiguring, Pityriasis Rubra Pilaris in a Woman in the Dominican Republic: Histopathologic Diagnosis and Response to Antiretroviral Therapy.

    Science.gov (United States)

    Lerebours-Nadal, Leonel; Beck-Sague, Consuelo M; Parker, Douglas; Gosman, Amanda; Saavedra, Arturo; Engel, Kristy; Dean, Andrew G

    2016-01-01

    Pityriasis rubra pilaris (PRP) is a poorly understood dermatologic condition usually accompanied by keratoderma and intense erythroderma with islands of unaffected skin. The PRP categories include HIV-associated PRP VI. A 23-year-old HIV-infected, dark-skinned woman in the Dominican Republic developed an extremely severe, disfiguring process characterized first by a dry scaly rash involving her face, trunk, and extremities with hyperpigmentation and islands of spared skin and minimal erythroderma, followed by alopecia and development of a thick horny layer on the scalp and face. The condition, histologically proven to be PRP, was accompanied by fever, wasting, and decline in CD4 count. Initiation of combination antiretroviral therapy (cART) was followed by rapid and sustained resolution of PRP. Nine years after ART initiation, she remains well, with viral suppression and immune recovery, without PRP recurrence but with sparse hair regrowth and facial scarring. In some dark-skinned patients, severe PRP may not feature characteristic erythroderma but will respond to combination ART. © The Author(s) 2015.

  13. The use of synchrotron infrared microspectroscopy in the assessment of cutaneous T-cell lymphoma vs. pityriasis lichenoides chronica.

    Science.gov (United States)

    El Bedewi, Ahmed; El Anany, Galal; El Mofty, Medhat; Kretlow, Ariane; Park, Simone; Miller, Lisa M

    2010-04-01

    The diagnosis of cutaneous lymphomas remains a challenge for both the clinician and dermatopathologist. To differentiate between frank malignant and premalignant lymphocytes within the skin. This study was performed on 20 patients with a mean age of 50 years. They were divided into two groups: mycosis fungoides (MF) (stage IA, IB and IIA) and pityriasis lichenoides chronica (PLC). Immunophenotyping using antibodies CD3, CD4, CD8, CD20 and CD30 was performed. Synchrotron Fourier transform infrared microspectroscopy (S-FTIRM) was performed on cell nuclei to assess chemical differences between MF and PLC cases as a potential complementary screening tool. Dermal spectra of both MF and PLC were compared using principal components analysis (PCA) of the S-FTIRM data. All PLC spectra was clustered together. However, the MF spectra formed two clusters, one that grouped with the PLC and the other grouped separately. Moreover, protein and nucleic acids showed highly significant differences between MF (IIA and IB), MF (IA) and PLC. The malignant transformation within lymphocytes was identifiable through the spectroscopic analysis of protein, RNA and DNA with S-FTIRM, making it a promising tool for classifying the progression of cutaneous T-cell lymphoma.

  14. Applicability of Proposed Diagnostic Criteria of Pityriasis Rosea: Results of a Prospective Case-Control Study in India

    Science.gov (United States)

    Zawar, Vijay; Chuh, Antonio

    2013-01-01

    Background: The diagnosis of pityriasis rosea (PR) is generally clinical. Previous studies usually recruited relatively small numbers of patients and control subjects, leading to low power of study results. Systematic reviews and meta-analyses cannot be readily performed, as the inclusion and exclusion criteria of these studies were not uniform. We have previously validated a set of diagnostic criteria (DC) in Chinese patients with PR. Aim: Our aim is to evaluate the validity and applicability of the DC of PR in Indian patients with PR. Study Design: Prospective unblinded pair-matched case-control study. Materials and Methods: The setting is a dermatology clinic in India served by one board-certified dermatologist. We recruited all 88 patients seen by us during five years diagnosed to have PR to join our study. For each study subject, we recruited the next patient who consulted us with differential diagnoses of PR as control subjects. We applied the DC of PR on all study and control subjects. Result: The sensitivity, specificity, positive predictive value, and negative predictive value of the DC were all 100%. Two-tailed Fisher's exact probability test result was 0.036. Φ was 1.00. Conclusion: The set of DC can be validly applied to Indian patients with PR. PMID:24249894

  15. An analysis of the Malassezia species distribution in the skin of patients with pityriasis versicolor in Chengdu, China.

    Science.gov (United States)

    Xie, Zhen; Ran, Yuping; Zhang, Hao; Zhang, Min; Wan, Huiying; Li, Conghui

    2014-01-01

    Pityriasis versicolor (PV) is a common clinical problem associated with Malassezia species (Malassezia spp.). Controversies remain regarding the specific species involved in the development of PV. This study analyzed the difference in Malassezia spp. distribution in lesional and nonlesional skin in Chinese PV patients. A paired design was applied. Lesional and nonlesional scales from 24 cases were collected; real-time fluorescence quantitative PCR was used to detect 10 different Malassezia spp. In lesional skin, the highest detection rates were for M. globosa (95.8%), M. restricta (91.7%), and M. sympodialis (50.0%). In nonlesional skin, the highest detection rates were for M. globosa (87.5%), M. restricta (79.2%), and M. dermatis (33.3%). A significant difference in the detection rate was only found for M. sympodialis (50.8% versus 20.8%, P = 0.04). Compared with nonlesional skin, the amount of M. globosa, M. restricta, and M. sympodialis in lesional skin was significantly higher (3.8 ± 1.3,  2.5 ± 1.1, and 3.2 ± 1.6 times higher, resp.). The results of this study do not indicate that M. globosa and M. restricta are directly correlated with PV development; however, M. sympodialis is more likely related to PV development in Chinese individuals.

  16. Flutrimazole shampoo 1% versus ketoconazole shampoo 2% in the treatment of pityriasis versicolor. A randomised double-blind comparative trial.

    Science.gov (United States)

    Rigopoulos, D; Gregoriou, S; Kontochristopoulos, G; Ifantides, A; Katsambas, A

    2007-05-01

    Flutrimazole is an imidazole derivative that has been proven to be efficient in superficial skin fungal infections. The aim of this randomised double-blind study was to compare for the first time, the efficiency and safety of flutrimazole 1% shampoo versus ketoconazole 2% shampoo in the treatment of tinea versicolor. Study population consisted of 60 patients with pityriasis versicolor diagnosed clinically and through direct microscopy and culture. Patients were randomly assigned to two groups: one instructed to apply flutrimazole shampoo 1% and one instructed to apply ketoconazole shampoo 2% both on head and body for 14 days. Patients were re-evaluated 14 days after the end of treatment clinically and through direct microscopy and culture. Twenty-one of 26 patients (80.8%) in the ketoconazole and 22 of 29 patients (75.9%) in the flutrimazole group had both visual healing and negative mycological evaluation. Comparison of the response between the two groups with the Yates' corrected chi-square was found statistically not significant (chi(2) = 0.19, d.f. = 1, P = 0.91). None of the patients in the two groups reported any adverse effects. Fourteen (53%) patients in the ketoconazole group and 23 (79%) in the flutrimazole group assessed the shampoos as cosmetically acceptable regarding texture, smell and foam properties. Flutrimazole shampoo 1% appears to present efficacy comparable with ketoconazole 2% in the treatment of tinea versicolor.

  17. Clinical analysis of 23 cases of pityriasis lichenoides%3例苔藓样糠疹的临床分析

    Institute of Scientific and Technical Information of China (English)

    冯素英; 靳培英

    2011-01-01

    目的 分析23例苔藓样糠疹(pityriasis lichenoides PL)患者的临床特点和治疗方案.方法 回顾性分析23例苔藓样糠疹患者的临床资料.结果 苔藓样糠疹患者以男性发病多(男:女=16:7),男性患者在急性痘疮样糠疹(pityriasis lichenoides et vsrioliformis acuta,PLEVA)中更占优势(7:2).10-20岁为其高发年龄段,PLEVA的发病年龄均在21岁以下,年龄的分布更集中.34.78%患者有上呼吸道感染史,慢性苔藓样糠疹(pityriasis lichenoides chronica,PLC)患者的病程较PLEVA的平均病程长.根据发病中的感染学说与药物本身具有抗炎作用,治疗的主要药物是口服红霉素或者四环素联合烟酰胺,病情严重者加用雷公藤多苷片.结论 苔藓样糠疹是一个可以控制的疾病,用药可以缩短病程.

  18. Comparative efficacy of topical application of tacrolimus and clotrimazole in the treatment of pityriasis versicolor: A single blind, randomised clinical trial.

    Science.gov (United States)

    Sepaskhah, Mozhdeh; Sadat, Maryam Sadat; Pakshir, Keyvan; Bagheri, Zahra

    2017-05-01

    Pityriasis versicolor (PV) is a common superficial fungal disease. Possibility of emergence of resistant strains to azoles, and difficulty in differentiation of hypopigmented PV and early vitiligo, encouraged us to evaluate the efficacy of topical tacrolimus (a calcineurin inhibitor agent with proven in vitro anti-Malassezia effect) for PV treatment generally and its effect on PV-induced hypopigmentation specifically. To evaluate the efficacy of topical tacrolimus on pityriasis versicolor. Fifty PV patients were randomly allocated into two equal groups applying either topical clotrimazol or tacrolimus twice daily for 3 weeks. They were evaluated at the beginning of study, in the third and fifth weeks clinically and mycologically (direct smear). Although both treatments resulted in global, clinical, and mycological cure of PV, there was no significant difference regarding the mentioned aspects of cure between tacrolimus and clotrimazole treated patients. (P-value: .63, .45, and .26, respectively) Tacrolimus had no significant effect on hypopigmentation in the fifth week follow-up. (P-value: .62). In spite of the lack of efficacy of tacrolimus on PV-induced hypopigmentation, the therapeutic effect on PV introduces tacrolimus as a therapeutic option for PV, especially when early vitiligo is among the differential diagnoses without concerning the aggravating effect of topical corticosteroids on PV. © 2017 Blackwell Verlag GmbH.

  19. Pitiríase versicolor circinada: isolamento de Malassezia sympodialis - Relato de caso Pityriasis versicolor circinata: isolation of Malassezia sympodialis - Case report

    Directory of Open Access Journals (Sweden)

    Valéria Maria de Souza Framil

    2010-04-01

    Full Text Available Os autores descrevem caso de pitiríase versicolor circinada, cujo agente etiológico isolado foi Malassezia sympodialis em uma mulher de 34 anos. O isolamento e identificação da Malassezia sympodialis foi em ágar Dixon modificado e o método molecular para confirmação da espécie foi PCR-RFLP (polymerase chain reaction and restriction fragment length polymorphism analysis.The authors report a case of pityriasis versicolor circinata whose isolated etiologic agent was Malassezia sympodialis in a 34-year-old woman. The isolation and identification of Malassezia sympodialis were accomplished with modified Dixon's agar, and the molecular method used to confirm the species was polymerase chain reaction and restriction fragment length polymorphism analysis (PCR-RFLP.

  20. A novel contrast stain for the rapid diagnosis of pityriasis versicolor: A comparison of Chicago Sky Blue 6B stain, potassium hydroxide mount and culture

    Directory of Open Access Journals (Sweden)

    Nikita Lodha

    2015-01-01

    Full Text Available Background: The mycological study of pityriasis versicolor is usually done by potassium hydroxide (KOH mount and culture. However, KOH mount lacks a color contrast and requires a trained eye to interpret, while culture is difficult to perform, time consuming and has low sensitivity. Chicago Sky Blue 6B (CSB is a new contrast stain that highlights the fungal hyphae and spores, blue against a purplish background. Aims and Objectives: This study was done to compare the utility of a novel contrast stain (CSB stain with KOH mount and culture. Materials and Methods: Skin scrapings from the lesions of 100 clinically diagnosed cases of P. versicolor were subjected to (1 KOH mount and CSB stain for direct microscopic examination and (2 culture using Sabouraud′s dextrose agar. The statistical analysis of CSB stain and culture was done using KOH mount as the reference method, as it is the most commonly performed and practical diagnostic test available for P. versicolor. An interrater reliability analysis using the Cohen′s Kappa statistic was performed to determine consistency (agreement among the different modalities. Observations and Results: Direct microscopy with CSB stain, KOH mount and mycological culture showed positive results in 98 (98%, 92 (92% and 56 (56% patients, respectively. Using KOH mount as the reference method, CSB stain had a sensitivity of 100% which was significantly higher than culture (60.9%. Statistically significant fair agreement was found between CSB stain and KOH mount (94% with κ=0.38, P < 0.001. Negligible agreement was found between CSB stain and culture (66%, κ=0.199, P = 0.001 as well as between KOH mount and culture (64%, κ=0.051, P = 0.107. Conclusion: CSB staining of skin scrapings is the most sensitive method for the diagnosis of pityriasis versicolor. Due to the distinct contrast provided by CSB, it is easy to perform, rapid and qualitatively superior to KOH mount.

  1. A Novel Contrast Stain for the Rapid Diagnosis of Pityriasis Versicolor: A Comparison of Chicago Sky Blue 6B Stain, Potassium Hydroxide Mount and Culture

    Science.gov (United States)

    Lodha, Nikita; Poojary, Shital Amin

    2015-01-01

    Background: The mycological study of pityriasis versicolor is usually done by potassium hydroxide (KOH) mount and culture. However, KOH mount lacks a color contrast and requires a trained eye to interpret, while culture is difficult to perform, time consuming and has low sensitivity. Chicago Sky Blue 6B (CSB) is a new contrast stain that highlights the fungal hyphae and spores, blue against a purplish background. Aims and Objectives: This study was done to compare the utility of a novel contrast stain (CSB stain) with KOH mount and culture. Materials and Methods: Skin scrapings from the lesions of 100 clinically diagnosed cases of P. versicolor were subjected to (1) KOH mount and CSB stain for direct microscopic examination and (2) culture using Sabouraud's dextrose agar. The statistical analysis of CSB stain and culture was done using KOH mount as the reference method, as it is the most commonly performed and practical diagnostic test available for P. versicolor. An interrater reliability analysis using the Cohen's Kappa statistic was performed to determine consistency (agreement) among the different modalities. Observations and Results: Direct microscopy with CSB stain, KOH mount and mycological culture showed positive results in 98 (98%), 92 (92%) and 56 (56%) patients, respectively. Using KOH mount as the reference method, CSB stain had a sensitivity of 100% which was significantly higher than culture (60.9%). Statistically significant fair agreement was found between CSB stain and KOH mount (94% with κ=0.38, P skin scrapings is the most sensitive method for the diagnosis of pityriasis versicolor. Due to the distinct contrast provided by CSB, it is easy to perform, rapid and qualitatively superior to KOH mount. PMID:26288400

  2. Double-Blind, Placebo-Controlled, Randomized Study Comparing 0.0003% Calcitriol with 0.1% Tacrolimus Ointments for the Treatment of Endemic Pityriasis Alba

    Directory of Open Access Journals (Sweden)

    Berenice Moreno-Cruz

    2012-01-01

    Full Text Available Background. Pityriasis alba (PA is a frequent cause of consultation in tropical areas due to its chronic course, frequent relapses, and notorious hypopigmented lesions in pediatric dark skin populations. Currently, no treatment is widely accepted. Objective. To assess the efficacy of 0.0003% calcitriol and 0.1% tacrolimus ointments compared with placebo in the treatment of endemic PA. Methods. Twenty-eight children aged 3–17 years with 56 symmetrical lesions and phototype IV-V, were randomly assigned to receive the treatments on target lesions on the face. Improvement was evaluated at baseline and 8 weeks later clinically and by digital quantification of the affected area, colorimetry, and transepidermal water loss (TEWL. Results. Tacrolimus and calcitriol ointments induced a mean improvement of 68%, compared to 44% of placebo. We found an elevated TEWL in PA lesions. In the treated plaques, the reduction of the affected area was associated with improvement of pigmentation and TEWL. Conclusions. Calcitriol and tacrolimus induced similar repigmentation in endemic PA lesions. Melanogenic, anti-inflammatory, and barrier defect restoration properties of these drugs may explain these findings.

  3. Is There a Link between Human Herpesvirus Infection and Toll-like Receptors in the Pathogenesis of Pityriasis Rosea? A Case-control Study.

    Science.gov (United States)

    El-Ela, Mostafa Abou; Shaarawy, Eman; El-Komy, Mohamed; Fawzy, Marwa; Hay, Rania Abdel; Hegazy, Rehab; Sharobim, Amin; Moustafa, Nadine; Rashed, Laila; Sayed Amr, Khalda Sayed

    2016-12-01

    Human herpesvirus (HHV) 6 and 7 are involved in the pathogenesis of pityriasis rosea (PR). Our aim was to evaluate the role of the innate immune response in PR through the detection of Toll-like receptors (TLR) 2, 3, 4, 7, 8, and 9 expression in the skin of affected patients and to detect the possibility of being induced by HHV-6 and/or HHV-7 viral coexistence in these patients. Twenty-four patients with PR and 24 healthy controls were included in this case-control study. Biopsy was obtained from the PR lesion and from the healthy skin of controls for detection of HHV-6 and 7 as well as TLRs 2, 3, 4, 7, 8, and 9 gene expression using real-time polymerase chain reaction (PCR). Significantly elevated expression of all studied TLRs and significantly higher viral load of HHV-6 and 7 in PR cases were detected. A significant higher expression of TLR2 and 4 in HHV-7 positive cases and a significant positive correlation between TLR9 and HHV-7 viral load were documented. HHV6 and 7 may also be involved in the pathogenesis of PR via TLR pathways.

  4. Gianotti-Crosti syndrome, pityriasis rosea, asymmetrical periflexural exanthem, unilateral mediothoracic exanthem, eruptive pseudoangiomatosis and papular-purpuric gloves and socks syndrome: a brief review and arguments for diagnostic criteria

    Directory of Open Access Journals (Sweden)

    Antonio Chuh

    2012-02-01

    Full Text Available Several exanthems including Gianotti-Crosti syndrome, pityriasis rosea, asymmetrical periflexural exanthem, eruptive pseudoangiomatosis, and papular-purpuric gloves and socks syndrome are suspected to be caused by viruses. These viruses are potentially dangerous. Gianotti-Crosti syndrome is related to hepatitis B virus infection which is the commonest cause of hepatocellular carcinoma, and Epstein-Barr virus infection which is related to nasopharyngeal carcinoma. Pityriasis rosea has been suspected to be related to human herpesvirus 7 and 8 infections, with the significance of the former still largely unknown, and the latter being a known cause of Kaposi’s sarcoma. Papular-purpuric gloves and socks syndrome is significantly associated with human B19 erythrovirus infection which can lead to aplastic anemia in individuals with congenital hemoglobinopathies, and when transmitted to pregnant women, can cause spontaneous abortions and congenital anomalies. With viral DNA sequence detection technologies, false positive results are common. We can no longer apply Koch’s postulates to establish causeeffect relationships. Biological properties of some viruses including lifelong latent infection, asymptomatic shedding, and endogenous reactivation render virological results on various body tissues difficult to interpret. We might not be able to confirm or refute viral causes for these rashes in the near future. Owing to the relatively small number of patients, virological and epidemiology studies, and treatment trials usually recruit few study and control subjects. This leads to low statistical powers and thus results have little clinical significance.

  5. Pityriasis Rosea, Gianotti-Crosti Syndrome, Asymmetric Periflexural Exanthem, Papular-Purpuric Gloves and Socks Syndrome, Eruptive Pseudoangiomatosis, and Eruptive Hypomelanosis: Do Their Epidemiological Data Substantiate Infectious Etiologies?

    Science.gov (United States)

    Zawar, Vijay; Sciallis, Gabriel F.; Kempf, Werner; Lee, Albert

    2016-01-01

    Many clinical and laboratory-based studies have been reported for skin rashes which may be due to viral infections, namely pityriasis rosea (PR), Gianotti-Crosti syndrome (GCS), asymmetric periflexural exanthem/unilateral laterothoracic exanthem (APE/ULE), papular-purpuric gloves and socks syndrome (PPGSS), and eruptive pseudo-angiomatosis (EP). Eruptive hypomelanosis (EH) is a newly discovered paraviral rash. Novel tools are now available to investigate the epidemiology of these rashes. To retrieve epidemiological data of these exanthema and analyze whether such substantiates or refutes infectious etiologies. We searched for articles published over the last 60 years and indexed by PubMed database. We then analyzed them for universality, demography, concurrent patients, temporal and spatial-temporal clustering, mini-epidemics, epidemics, and other clinical and geographical associations. Based on our criteria, we selected 55, 60, 29, 36, 20, and 4 articles for PR, GCS, APE/ULE, PPGSS, EP, and EH respectively. Universality or multiple-continental reports are found for all exanthema except EH. The ages of patients are compatible with infectious causes for PR, GCS, APE/ULE, and EH. Concurrent patients are reported for all. Significant patient clustering is demonstrated for PR and GCS. Mini-epidemics and epidemics have been reported for GCS, EP, and EH. The current epidemiological data supports, to a moderate extent, that PR, GCS, and APE could be caused by infectious agents. Support for PPGSS is marginal. Epidemiological evidences for infectious origins for EP and EH are inadequate. There might be growing epidemiological evidence to substantiate or to refute our findings in the future. PMID:27103975

  6. Pityriasis rosea, Gianotti-Crosti syndrome, asymmetric periflexural exanthem, papular-purpuric gloves and socks syndrome, eruptive pseudoangiomatosis, and eruptive hypomelanosis: do their epidemiological data substantiate infectious etiologies?

    Directory of Open Access Journals (Sweden)

    Antonio Chuh

    2016-03-01

    Full Text Available Many clinical and laboratory-based studies have been reported for skin rashes which may be due to viral infections, namely pityriasis rosea (PR, Gianotti-Crosti syndrome (GCS, asymmetric periflexural exanthem/unilateral laterothoracic exanthem (APE/ULE, papularpurpuric gloves and socks syndrome (PPGSS, and eruptive pseudo-angiomatosis (EP. Eruptive hypomelanosis (EH is a newly discovered paraviral rash. Novel tools are now available to investigate the epidemiology of these rashes. To retrieve epidemiological data of these exanthema and analyze whether such substantiates or refutes infectious etiologies. We searched for articles published over the last 60 years and indexed by PubMed database. We then analyzed them for universality, demography, concurrent patients, temporal and spatial-temporal clustering, mini-epidemics, epidemics, and other clinical and geographical associations. Based on our criteria, we selected 55, 60, 29, 36, 20, and 4 articles for PR, GCS, APE/ULE, PPGSS, EP, and EH respectively. Universality or multiple-continental reports are found for all exanthema except EH. The ages of patients are compatible with infectious causes for PR, GCS, APE/ULE, and EH. Concurrent patients are reported for all. Significant patient clustering is demonstrated for PR and GCS. Mini-epidemics and epidemics have been reported for GCS, EP, and EH. The current epidemiological data supports, to a moderate extent, that PR, GCS, and APE could be caused by infectious agents. Support for PPGSS is marginal. Epidemiological evidences for infectious origins for EP and EH are inadequate. There might be growing epidemiological evidence to substantiate or to refute our findings in the future.

  7. Role of Malassezia in the color diversity of pityriasis versicolor%马拉色菌在花斑癣色素改变中的作用

    Institute of Scientific and Technical Information of China (English)

    崔凡; 余晓东; 李筱芳; 陈先进; 沈永年; 吕桂霞; 刘维达

    2008-01-01

    Objective To investigate the influence of Malassezia isolates that can cause hyperpigmentation or hypopigmentation in patients with pityriasis versicolor on the melanogenesis of B16F10 melanoma cells.and to detect the levels of cytokines associated with melanogenesis.Methods Primary culture of keratinocytes(1×106 cells/mL)derived from human prepuce were co-cultured with Malassezia strains isolated from hyperpigmented or hypopigmented lesions in the same patient with pityriasis versicolor,with the concentration ratio of keratinocytes to Malassezia cells being 1:1,1:10,1:20 and 1:30,respectively.The proliferation rate of keratinocytes was detected by MTT methOd.To observe the influence on B16F10 melanoma cells.five difierent types of culture supematant were prepared,i.e.the supematant from culture system of keratinocytes alone,supematant from the coculture system of keratinocytes and Malassezia isolates from hyperpigmented sites or hypopigmented sites,and supernatant from keratinocyte culture in the presence of Malassezia cell-free supematant from the culture medium of Malassezia strains from hyperpigmented or hypopigmented sites.ELISA test was performed in these supematants to detect the levels of several eytokines associated with melanogenesis,including basic fibroblast growth factor(b-FGF),endothelin-1,nerve growth factor(NGF)-β,IL-1α,lL-6,tumor necrosis factor(TNF)-α and stem cell factor(SCF).B16F10 cells were cultured with the above 5 supematants.After 48-hour culture.the proliferation rate of B16F10 cells was measured with MTT method,melanin content by NaOH assay.expression and activity of tyrosinase via Western blot and dopa-oxidase assay,respectively.Results The growth rate of keratinocytes was not affected by MalassczJa(P>0.05)when the concentration ratio of keratinocytes to Malassezia cells was more than 1:20.The melanin content,tyrosinase activity and expression of tyrosinase of B16F10 cells were inereased in the presence of supernatant from co

  8. Pityriasis lichenoides et varioliformis acuta with numerous CD30(+) cells: a variant mimicking lymphomatoid papulosis and other cutaneous lymphomas. A clinicopathologic, immunohistochemical, and molecular biological study of 13 cases.

    Science.gov (United States)

    Kempf, Werner; Kazakov, Dmitry V; Palmedo, Gabriele; Fraitag, Sylvie; Schaerer, Leo; Kutzner, Heinz

    2012-07-01

    Pityriasis lichenoides comprises a clinicopathologic spectrum of cutaneous inflammatory disorders, with the 2 most common variants being pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis lichenoides chronica. The aim of the study was to describe 13 cases of a unique PLEVA variant characterized in the conspicuous CD30 component and thus mimicking lymphomatoid papulosis (LyP), a condition currently classified in the spectrum of CD30 lymphoproliferative disorders. The cohort included 10 female and 3 male patients whose ages at diagnosis ranged from 7 to 89 years (mean 41 y; median 39 y). The clinical manifestation was that of PLEVA, with small erythematous macules quickly evolving into necrotic papules. No waxing and waning was seen on follow-up in any of the cases. Histopathologically, typical features of PLEVA were present, but an unusual finding was occurrence of a considerable number of CD30 small lymphocytes as detected immunohistochemically. Over half of the cases also displayed a large number of CD8 cells and showed coexpression of CD8 and CD30 in the intraepidermal and dermal component of the infiltrate. Of the 11 cases of PLEVA studied for T-cell receptor gene rearrangement, 6 evidenced a monoclonal T-cell population, and 5 were polyclonal. Parvovirus B19 (PVB19) DNA was identified in 4 of 10 cases investigated, and positive serology was observed for PVB19 in 2 patients, altogether suggesting that PVB19 is pathogenetically linked to PLEVA at least in a subset of cases. The presence of CD30 lymphocytes and CD8 lymphocytes would be consistent with an inflammatory antiviral response, as CD30, even atypically appearing lymphoid cells have been identified in some viral skin diseases. The main significance of the PLEVA variant is, however, its potential confusion with LyP or some cytotoxic lymphomas. Admittedly, the CD30 PLEVA variant described herein and LyP show considerable overlap if one takes into account all known variations of the 2

  9. Identificação de espécies de Malassezia em pacientes com pitiríase versicolor em Goiânia-GO Identification of Malassezia species in patients with pityriasis versicolor in Goiânia-GO

    Directory of Open Access Journals (Sweden)

    Karla Carvalho Miranda

    2006-12-01

    Full Text Available O objetivo deste estudo foi verificar a freqüência de pitiríase versicolor e identificar leveduras do gênero Malassezia, de pacientes encaminhados ao laboratório de Micologia da Universidade Federal de Goiás em Goiânia. Foram diagnosticados 95 casos de pitíriase versicolor e identificados quatro espécies de Malassezia: Malassezia furfur, Malassezia sympodialis, Malassezia globosa e Malassezia obtusa.The objectives of this study were to investigate the frequency of pityriasis versicolor occurrence and to identify yeasts of the genus Malassezia in patients at the mycology laboratory of the Federal University of Goiás, in Goiânia, State of Goiás. Ninety-five cases of pityriasis versicolor were diagnosed, and four species of Malassezia were identified: Malassezia furfur, Malassezia sympodialis, Malassezia globosa and Malassezia obtusa.

  10. 483例儿童花斑癣回顾性分析%Pityriasis versicolor in children: a retrospective study of 483 cases

    Institute of Scientific and Technical Information of China (English)

    施和建; 张国龙; 杜旭峰; 周晴; 王涛; 邵敏华; 黄海峰

    2008-01-01

    目的总结及分析儿童花斑癣患者的临床特点,比较与成人花斑癣的异同点.方法就诊于我院皮肤科门诊的花斑癣患者认真填写问卷调查表,内容包括:性别、年龄、发病年龄,病程、皮损部位、诱因、发病季节、家族史.并进行真菌学检查.结果儿童花斑癣患者共483例,其中男286例,占59.2%,女197例,占40.8%.年龄15天至12岁.所有患儿面部发病207例,占42.9%,其中发生于前额的共143例,占面部发病的69.1%.多汗患儿405例,占83.9%.有家族史38例,占7.9%.所有患儿均采用1%联苯苄唑乳膏外用,治疗2周以上,447例患儿通过治疗后得到有效的临床症状改善及病原学疗效,总有效率为92.5%.结论儿童花斑癣同成人花斑癣比较有不同的临床特点,发病因素与成人不尽相同,且在诊断上需与儿童面部色素减退性皮肤病进行鉴别.%Objective To assess the clinical characteristics of pityriasis versicolor (PV) in children vs adults. Methods Questionnaire was designed and given to consecutive patients with PV in the Department of Dermatology, Wuxi Children's Hospital, for collection of information on their sex, age, onset age, duration of disease, localization of lesions, inducement, onset season, and family history. Findings on mycological examination before and after medication were assessed. Results Totally, 483 children with PV were enrolled, including 286 (59.2%) boys and 197 (40.8%) girls. Patients aged from 15 days to 12 years. Facial lesions were the most frequent (n = 207, 42.9% ) manifestation with a preference on the forehead (n = 143, 69.1% ). Hyperhidrosis was found in 405 (83.9%) patients, and family history of PV in 38 (7.9%) patients. Patients were instructed to apply bifonazole 1% cream on lesions. After more than 2 weeks of treatment, 447 (92.5%) patients obtained both clinical and mycological improvement. Conclusions Difference is present between pediatric and adult PV in clinical manifestations

  11. Malassezia Species and Pityriasis Versicolor

    National Research Council Canada - National Science Library

    Rodoplu, Gulin

    2016-01-01

    Malassezia species are found in part of the normal human cutaneous commensal flora, however it has been known for many years that the Malassezia yeasts are associated with a number of different human...

  12. Treatment Effect and Safety of Naftifine/ketoconazole Cream to Facial Pityriasis Versicolor in Children%萘替芬酮康唑乳膏治疗儿童面部花斑癣的疗效观察

    Institute of Scientific and Technical Information of China (English)

    李麟

    2014-01-01

    目的:观察萘替芬酮康唑乳膏治疗儿童面部花斑癣的疗效与安全。方法:将95例患儿随机分成治疗组和对照组,治疗组外用萘替芬酮康唑乳膏,对照组外用特比奈芬软膏,于治疗2、4周后观察疗效及有无不适反应,并根据真菌镜检结果判定疗效。结果:治疗组治疗2周时治愈率为90%,4周时治愈率为100%,不适反应率为10%;对照组治疗2周时治愈率为71%,4周时治愈率为84%,不适反应率为27%。两组有效率及安全性差异有统计学意义(P<0.05)。结论:萘替芬酮康唑乳膏治疗儿童面部花斑癣安全而有效。%Objective:To observe the clinical efficiency and safety in the treatment of facial pityriasis versicolor in children with Naftifine/Ketoconazole Cream. Methods:95 children patients were randomly divided into treatment group and control group. Naftifine/ketoconazole cream were applied in the treatment group, and Terbinafine were applied in the control group. The clinical efficiency and side effects were evaluated 2 and 4 weeks later, and therapeutic effect was determined according to the results of fungus infection.Results:At the end of 2 weeks and 4 weeks, the efficacy of the treatment group was 90%and 100%, while control group was 71%and 84%. The side effects of treatment group was 10%, and control group 27%. All of them had significant difference (P<0.05). Conclusion:Naftifine/ketoconazole cream is efficient and safe to treat facial pityriasis versicolor in the children.

  13. Pitiríase versicolor: isolamento e identificação das principais espécies de Malassezia Pityriasis versicolor: isolation and identification of the main species

    Directory of Open Access Journals (Sweden)

    Valéria Maria de Souza Framil

    2010-02-01

    Full Text Available As espécies do gênero Malassezia isoladas foram: Malassezia sympodialis (16,66%, Malassezia furfur (12,50%, Malassezia globosa (11,45% e Malassezia slooffiae (2,10%. A Malassezia sympodialis foi a espécie que predominou em nosso estudo. As espécies de Malassezia identificadas não mostraram correlação com as variantes clínicas e com a distribuição das lesões de pitiríase versicolor quanto às regiões do corpo.Species of the genus Malassezia isolated were: Malassezia sympodialis (16.66%, Malassezia furfur (12.50%, Malassezia globosa (11.45%, and Malassezia slooffiae (2.10%. Malassezia sympodialis predominated in the study. The species of Malassezia identified did not show correlation with clinical variants and with the distribution of pityriasis versicolor lesions in relation to areas of the body.

  14. γδ T-cell-rich variants of pityriasis lichenoides and lymphomatoid papulosis: benign cutaneous disorders to be distinguished from aggressive cutaneous γδ T-cell lymphomas.

    Science.gov (United States)

    Martinez-Escala, M E; Sidiropoulos, M; Deonizio, J; Gerami, P; Kadin, M E; Guitart, J

    2015-02-01

    T cells with a γδ phenotype have been associated with aggressive lymphomas. Yet, inflammatory skin disorders and low-grade lymphoproliferative disorders have rarely been described with a predominant γδ T-cell infiltrate. To review our experience and determine the clinical relevance of the γδ T-cell phenotype in lymphomatoid papulosis (LyP) and pityriasis lichenoides (PL). A retrospective dermatopathology file review looking for LyP and PL characterized by a γδ T-cell phenotype was performed. Clinical manifestations and course, histological features and molecular data were analyzed. Six of 16 cases of LyP and four of 23 cases diagnosed as PL during a 5-year period (2009-14) were identified. The median follow-up for the whole group was 16 months (range 3-64), showing an indolent clinical course in all cases. The detection of a predominantly γδ T-cell phenotype in papular lymphoid-rich infiltrates in the absence of other lesions is not associated with a clinically aggressive course. γδ T-cell-rich variants of LyP and PL may reflect a spectrum of related conditions. This is a single academic centre retrospective chart review of a relatively small sample. © 2014 British Association of Dermatologists.

  15. Gianotti-Crosti syndrome, pityriasis rosea, asymmetrical periflexural exanthem, unilateral mediothoracic exanthem, eruptive pseudoangiomatosis, and papular-purpuric gloves and socks syndrome: a brief review and arguments for diagnostic criteria

    Science.gov (United States)

    Chuh, Antonio; Zawar, Vijay; Law, Michelle; Sciallis, Gabriel

    2012-01-01

    Several exanthems including Gianotti-Crosti syndrome, pityriasis rosea, asymmetrical periflexural exanthem, eruptive pseudoangiomatosis, and papular-purpuric gloves and socks syndrome are suspected to be caused by viruses. These viruses are potentially dangerous. Gianotti-Crosti syndrome is related to hepatitis B virus infection which is the commonest cause of hepatocellular carcinoma, and Epstein-Barr virus infection which is related to nasopharyngeal carcinoma. Pityriasis rosea has been suspected to be related to human herpesvirus 7 and 8 infections, with the significance of the former still largely unknown, and the latter being a known cause of Kaposi's sarcoma. Papular-purpuric gloves and socks syndrome is significantly associated with human B19 erythrovirus infection which can lead to aplastic anemia in individuals with congenital hemoglobinopathies, and when transmitted to pregnant women, can cause spontaneous abortions and congenital anomalies. With viral DNA sequence detection technologies, false positive results are common. We can no longer apply Koch's postulates to establish cause-effect relationships. Biological properties of some viruses including lifelong latent infection, asymptomatic shedding, and endogenous reactivation render virological results on various body tissues difficult to interpret. We might not be able to confirm or refute viral causes for these rashes in the near future. Owing to the relatively small number of patients, virological and epidemiology studies, and treatment trials usually recruit few study and control subjects. This leads to low statistical powers and thus results have little clinical significance. Moreover, studies with few patients are less likely to be accepted by mainstream dermatology journals, leading to publication bias. Aggregation of data by meta-analyses on many studies each with a small number of patients can theoretically elevate the power of the results. Techniques are also in place to compensate for

  16. 从花斑糠疹皮损分离的马拉色菌随机扩增多态性DNA研究%Random amplified polymorphic DNA analysis of Malassezia isolates from cutaneous lesions of pityriasis versicolor

    Institute of Scientific and Technical Information of China (English)

    谢震; 冉玉平; 刘瑞; 杨如学; 李志瑜; 代亚玲

    2009-01-01

    目的 用随机扩增多态性DNA方法 研究分离自花斑糠疹的马拉色菌种间和株间差异,了解随机扩增多态性DNA分析(RAPD)与生理生化方法 在菌种分型上的差异及菌株DNA型别和菌种间的关系.方法 用氯化苄法提取马拉色菌标准株(10株7个种)和临床分离株(47株)的基因组DNA,其中临床株分离自34例花斑糠疹患者,经形态学和生理生化方法 鉴定为5个种(合轴马拉色菌、糠秕马拉色菌、钝形马拉色菌、球形马拉色菌、限制马拉色菌),用4种随机引物(S22、SS24、S25、S33)对菌株DNA做PCR随机扩增,NTSYS软件自动生成树状分支图.结果 绝大多数标本均可被4种引物扩增而获得清晰条带,其中2种引物(S22、S24)的条带更为稳定、清晰.共82条DNA片段被扩增,所有菌株均可见种间和株间多态性.有4例患者皮损同时分离出不同种的菌株显示遗传相似性高,在树状图中归入一类.结论 来自同一宿主的不同菌株遗传趋同现象提示马拉色菌的种特异性、菌种演化与宿主间存在密切关系.%Objective To investigate intraspecific and interspecific variation within Malassezia iso-lates from patients with pityriasis versicolor by random amplified polymorphic DNA (RAPD) analysis, to learn the difference between RAPD analysis and physiological and biochemical methods in the typing of Malassezia species, and to explore the relationship between RAPD patterns and Malassezia species. Methods A total of 47 Malassezia isolates were obtained from 34 patients with pityriasis versicolor, and they were classified into 5 species by morphological, physiological and biochemical features, I.e., M. Fin'fur, M. Obtusa, M. Globosa, M. Restricta and M. Sympodialis. Genomic DNA was extracted from the 47 clinical isolates and 10 reference strains (including 7 species) of Malassezia. PCR was performed using 4 random primers including S22, S24, S25 and S33. RAPD patterns were analyzed by NTSYS

  17. Efficacy and tolerability of a cream containing AR-GG27® (sorbityl furfural palmitate) in the treatment of mild/moderate childhood atopic dermatitis associated with pityriasis alba. A double-blind, placebo-controlled clinical trial.

    Science.gov (United States)

    Patrizi, A; Raone, B; Raboni, R; Neri, I

    2012-12-01

    Pityriasis alba (PA) is a skin disorder characterized by finely scaly, hypopigmented patches, typical of childhood, that also represents an atopic dermatitis (AD) minor sign according to Hanifin and Rajka criteria. It may be isolated or associated with AD representing, sometimes an atypical manifestation of AD during the long-term follow-up of the disease. Aim of the study was to evaluate of the efficacy and tolerability of AR-GG27® (sorbityl furfural palmitate) cream in the treatment of childhood mild or moderate AD associated with PA. The trial is a single center, double-blind, randomized, placebo-controlled study. The study included patients of both sexes, aged between two months and 15 years, suffering from mild and moderate AD always associated with PA. Xerosis was present in all patients. The treatment with topical steroids or topical calcineurin inhibitors (TIMs) had to be suspended for at least 15 days. Any systemic therapy and phototherapy or sun exposure were withdrawn at least 30 days before. Emollients were stopped at least seven days before. During the trial, no other local or systemic treatments were allowed, as well as sun exposure. Patients affected by AD with viral, bacterial or fungal overinfection or patients with diabetes mellitus, severe systemic diseases or intolerance to one or more components of the product were excluded. The primary endpoint was the evaluation of the average change in the Investigator Global Assessment (IGA) after 15 and 30 days of treatment. The second endpoint was the evaluation of severity of three different clinical signs: erythema, excoriation desquamation, using a subjective five-point scale. Changes in pruritus severity was also considered during the entire period of treatment, through the use of a Visual Analogue Scale (VAS). A Pskin conditions characterized by inflammation and tissue oxidative stress in children, as PA with mild and moderate AD.

  18. Nested PCR analysis for malassezia microflora from the scales of patients with pityriasis versicolor%花斑癣患者皮屑中马拉色菌的巢式PCR法分析

    Institute of Scientific and Technical Information of China (English)

    赵秀红; 冉玉平; 熊琳; 周光平; 山崎; 坪井良治; 小川秀兴

    2004-01-01

    目的用巢式PCR法检测马拉色菌特异的DNA从而快速准确的检测并鉴定马拉色菌的各菌种,并应用于花斑癣(Pityriasis Versicolor,PV)患者皮屑中马拉色菌携带情况中的研究.方法从PV患者的皮屑中提取马拉色菌的DNA,以马拉色菌属rRNA内转录间隔区设计属的引物和各个种的特异性引物分别进行巢式多聚酶链反应(nestPCR),检测105例PV患者皮屑中的马拉色菌的目的DNA片断.结果105例PV患者共检测到5例种的共321株马拉色菌的DNA.每例患者平均检测到约3种马拉色菌的DNA.各种马拉色菌的检出率依次为:球形马拉色菌80.0%,限制马拉色菌81.9%,合轴马拉色菌77.1%,糠秕马拉色菌41.9%,钝形马拉色菌15.2%.未检测到厚皮马拉色菌和斯洛菲马拉色菌.结论PV皮屑中存在多种马拉色菌,球形马拉色菌、合轴马拉色菌和限制马拉色菌是PV患者皮损处的主要马拉色菌种.

  19. 急性痘疮样糠疹合并结节性血管炎1例%A Case Report of Pityriasis Lichenoides Etvarioliformis Acuta And Nodular Vasculitis

    Institute of Scientific and Technical Information of China (English)

    雷微; 陈永艳; 袁伟; 黄洋

    2011-01-01

    患者女,26岁.全身丘疹3月,四肢结节伴疼痛10天.皮损为圆形丘疹,表面有鳞屑覆盖,周围绕以红晕,以四肢明显,部分丘疹中心萎缩凹陷;左前臂、双小腿伸侧散在红色皮下结节,有压痛感.组织病理示:①小腿丘疹:表皮内见基底细胞灶性液化变性,真皮浅层血管周围大量淋巴细胞、组织细胞浸润,可见血管外红细胞.②小腿结节:皮下脂肪组织内见一大血管破坏,周围脂肪小叶弥漫性炎细胞浸润.诊断:急性痘疮样糠疹合并结节性血管炎.%A26-year-old female presented with body pimples for three months, limbs nodules with tendemess for ten days. Lcsions are round papules to clear limbs, and which surface with scales, and around to flush, some papules center atrophy depression; the red subcutaneous nodule on the left forearm and shank with tenderness. After histopathological examination, the pathologic slice of the papules on her shank shows focal liquefaction degeneration of basal cell in the epidermis, a large number of lymphocytes and histocytes around the superficial dermal vessels. and some crythrocytes out of the vessel. The nodules of her shank pathologica slice shows the angiolysis in the subcutancous adipose tissue and the surrounding fat lobules with diffuse infiltration of inflammatory cells. Diagnosis: Pityriasis lichcnoides etvarioliformis acuta and nodular vaseulitis.

  20. Analysis on the triggering factors of pityriasis versicolor, Malassezia folliculitis and seborrheic dermatitis%花斑癣、马拉色菌毛囊炎、脂溢性皮炎马拉色菌诱发因素分析

    Institute of Scientific and Technical Information of China (English)

    许雪; 李红宾; 黄云丽; 李玉叶; 董天祥; 林松发; 程露

    2014-01-01

    Objective To investigate the triggering factors of pityriasis versicolor , Malassezia folliculitis and seb-orrheic dermatitis.Methods Survey among the patients with pityriasis versicolor, Malassezia folliculitis or seborrheic dermatitis was performed by questionnaire.Results Of the 158 patients, there were 104 males and 54 females, aged 29.4 years.The proportion of patients with hyperidrosis and oily skin is more than 60%.Systemic or topical applica-tion of corticosteroids was the main risk factor of Malassezia folliculitis.Conclusion Malassezia infection was com-mon in young adults.Pityriasis vesicolor was common in patient with hyperidrosis.The oily skin and application of corticosteroids were the main triggering factor of Malassezia folliculitis.%目的调查昆明地区花斑癣、马拉色菌毛囊炎、脂溢性皮炎马拉色菌诱发因素,并比较三种疾病的诱发因素有无差异。方法收集花斑癣、马拉色菌毛囊炎、脂溢性皮炎(头皮屑)的病例,用自制的调查表对入选病例进行诱发因素调查,比较诱发因素在三种疾病间有无差异。结果共收集158例病例,男104例,女54例,平均年龄29.4岁,多汗、油性皮肤患者所占比例均超过60%,系统或局部使用糖皮质激素是马拉色菌毛囊炎的危险因素。结论马拉色菌感染好发于男性青壮年,多汗者易发生花斑癣,油性皮肤及使用糖皮质激素易发生马拉色菌毛囊炎。

  1. 急性痘疮样苔藓样糠疹64例临床分析%Clinical analysis of 64 cases with pityriasis lichenoides et varioliformis acuta

    Institute of Scientific and Technical Information of China (English)

    封常霞; 韩娜娜; 周江峰; 李君

    2014-01-01

    目的:分析急性痘疮样苔藓样糠疹(PLEVA)临床特征和疗效。方法:对64例 PLEVA 患者进行回顾性分析。结果:(1)64例患者中男女发病率之比为4.3∶1;(2)29.69%的患者发病前有感染史,93.75%的患者皮损具有多形性,43.75%症状较重者出现白细胞计数、转氨酶、免疫球蛋白(IgM、IgG、IgA)等实验室检查指标异常;(3)组织病理:淋巴细胞性血管炎,淋巴细胞、红细胞游入表皮为特征;(4)糖皮质激素、窄波中波紫外线(NB-UVB)、雷公藤多苷、四环素、甘草酸二胺等联合治疗有效。结论: PLEVA 临床表现多样性,治疗以糖皮质激素为主。%Objective: To analyze the clinical features and treatment of pityriasis lichenoides et variolifor-mis acuta (PLEVA). Methods: We retrospectively analyzed the clinical and laboratory data of 64 patients di-agnosed as PLEVA. Results: (1) The ratio between male and female was 4.3 ∶1. (2) 29.69% of the patients had an infection history before the onset of the disease. Pleomorphic skin lesions, such as erythema, papules, necrosis, ulceration, et al were seen in 93.75% of the patients. The abnormal laboratory tests such as white blood cell count, aminotransferase, immunoglobulin (IgM, IgG, IgA) were seen in 43.75% of severe pa-tients. (3) The pathological examination showed lymphocytic vasculitis, migration of lymphocytes and erythro-cytes into the epidermis. (4) The treatments including glucocorticoids, NB-UVB, TWP, tetracycline and gly-cyrrhizin diamine were effective. In severe PLEVA (39.06%) glucocoriticoid had been used in a combination with other drugs. Conclusion: PLEVA has a variety of clinical manifestations and steroid is till the mainstay in the treatment.

  2. Expression and significance of FOXP3 in pityriasis rosea, lichen planus, large-plaque parapsoriasis and mycosis fungoides%FOXP3在玫瑰糠疹、扁平苔藓、大斑块型副银屑病及蕈样肉芽肿中的表达及意义

    Institute of Scientific and Technical Information of China (English)

    周秉侠; 郭淑兰; 许艳静

    2012-01-01

    Objective To investigate expression and significance of fork-head box protein-3 (FOXP3) in normal skins, pityriasis rosea, lichen planus, large-plaque parapsoriasis, and mycosis fungoides. Methods The immunohistochemi-cal EnVision method was applied to detect expression of FOXP3 in 21 cases of pityriasis rosea, 19 cases of lichen planus , 17 cases of large-plaque parapsoriasis, 22 cases of mycosis fungoides, and 10 normal skin controls. Results Rates of FOXP3 -positive lymphocytes in lesions of pityriasis rosea and lichen planus had no significant difference compared with normal skin (P >0.05). Rates of FOXP3-positive lymphocytes in lesions of large-plaque parapsoriasis and mycosis fungoides were higher than those in pityriasis rosea, lichen planus, and normal skin(P 0. 05). Conclusions FOXP3-positive lymphocytes show a gradual increasing tendency in inflammatory skin diseases, tumor tendency inflammatory skin diseases and cutaneous lymphoma. They may play an important role in immune escape of tumors and promote tumor occurrence and development.%目的 探讨叉头状转录因子P3( FOXP3)在玫瑰糠疹、扁平苔藓、大斑块型副银屑病及蕈样肉芽肿中的表达及意义.方法 采用免疫组织化学EnVision法检测21例玫瑰糠疹、19例扁平苔藓、17例大斑块型副银屑病、22例蕈样肉芽肿及10例正常人皮肤中FOXP3的表达.结果 玫瑰糠疹、扁平苔藓皮损中FOXP3+淋巴细胞阳性率与正常人皮肤中的表达差异无统计学意义(P>0.05);大斑块型副银屑病与蕈样肉芽肿皮损中FOXP3+淋巴细胞阳性率均高于玫瑰糠疹、扁平苔藓及正常皮肤(P<0.05),但其二者之间的表达差异无统计学意义(P>0.05).结论 FOXP3+淋巴细胞阳性率在炎症性皮肤病、有肿瘤发展倾向的炎症性皮肤病及皮肤淋巴瘤中的表达有逐步增高的趋势.其增多可能为肿瘤细胞的免疫逃逸提供了条件,进而促进了肿瘤的发生、发展.

  3. Pitiriasis liquenoide: estudio retrospectivo clínico epidemiológico de 49 pacientes pediátricos Pityriasis lichenoides: a retrospective clinical and epidemiological study of 49 pediatric patients

    Directory of Open Access Journals (Sweden)

    GP Sciancalepore

    Full Text Available La pitiriasis liquenoide (PL, entidad pápulo-escamosa, afecta principalmente a niños. Presenta una forma aguda, "pitiriasis liquenoide y varioliforme aguda" (PLEVA y otra crónica, la pitiriasis liquenoide crónica (PLC. Objetivo: describir las características de pacientes con diagnóstico clínico e histopatológico de PL. Comparar nuestros resultados con los hallados en la bibliografía. Materiales y Métodos: historias clínicas e informes anátomo-patológicos de 49 pacientes que consultaron entre marzo de 2000 a marzo de 2011. Se analizaron los datos obtenidos mediante el programa SPSS 11.5. Resultados: de 49 pacientes con PL, 17 presentaron PLEVA y 32 PLC. El promedio de edad de inicio de PLEVA fue de 6 años y de 10 años para PLC. Predominó el sexo masculino en PLEVA. Las formas generalizadas parecieran ser las predominantes. Las lesiones más frecuentemente halladas fueron: pápulas y pápulas eritematosas en PLEVA, escamas en PLC y las máculas hipocrómicas como discromía residual. 14 de 49 pacientes mostraron asociaciones mórbidas. Conclusiones: la PL puede ser dividida en aguda y crónica, a pesar de existir ambas clases de lesiones en un mismo paciente. PLEVA se presentó a edades más tempranas, predominando en varones. De los pacientes que presentaron co-morbilidades, la mayoría comprometía la inmunidad.Background: the pityriasis lichenoides (PL, a papulosquamous disease, affects mostly children. Present an acute form, pytiriasis lichenoides et varioliformis acute (PLEVA and other chronic, chronic lichenoid pytiriasis (PLC. Objetive: to describe the caracheristics of patients with clinic and histopathological diagnosis of PL. Compare our results with those found in the literature. Materials and Methods: clinical records and pathology reports of 49 patients who consulted between March 2000 and March 2011. Data were analyzed using SPSS 11.5. Results: of 49 patients with PL, 17 presented PLEVA and 32 PLC. The average age of

  4. 花斑糠疹和马拉色菌毛囊炎致病菌菌种分析%Study the Pathogenic Species of Pityriasis Versicolor and Malassezia Folliculitis

    Institute of Scientific and Technical Information of China (English)

    耿承芳; 占萍; 陶丽; 李智华; 江清; 金云; 罗云鹏

    2011-01-01

    目的 使用限制性内切酶方法鉴定临床花斑糠疹和马拉色菌毛囊炎致病菌菌种分布并比较其差异.方法 收集临床花斑糠疹和马拉色菌毛囊炎标本,植于Leeming-Notman培养基.培养阳性菌株提取DNA,扩增其26srDNA片段,用Cfo Ⅰ酶和BstF51酶切.结果 共鉴定花斑糠疹阳性菌株128份,其中糠秕马拉色菌49份,合轴马拉色菌23份,球形马拉色菌26份,钝性马拉色菌6份,M.japponica 1份,斯洛菲马拉色菌1份,混合感染标本22份.共鉴定马拉色菌毛囊炎阳性标本70份,其中糠秕马拉色菌43株,合轴马拉色菌5株,球形马拉色菌9株,钝性马拉色菌1株,混合感染标本12份.两种疾病菌种分布差异存在统计学意义(P=0.009).结论 花斑糠疹和马拉色菌毛囊炎致病菌菌种存在一定差异.限制性酶切方法为一种准确、快速的马拉色菌菌种鉴定方法.%Objective To investigate the pathogenic species in patients of Pityriasis versicolor (PV) and Malassezia folliculitis(MF). Methods Clinical specimens from PV and MF patients were collected and cultured onto Leeming-Notman medium. DNA was extracted from positve cultures followed by the polymerase chain reaction-restriction fragment length polymorphism with 2 restriction enzymes, CfoI and BstF51. Results One hundred and twenty-eight cultures from PV were identified with 49 strains of M. furfur, 23 M. sympodialis,26 M. globosa, 6 M. obtuse, 1 M. japonica, 1 M. slooffiae and 22 mixed infections, respectively. Seventy cultures from MF were identified with 43 strains of M. furfur, 5M. sympodialis, 29 M. globosa, 1 M. obtuse,12 mixed infections, respectively. The distribution of malassezia species was significantly different between the two groups (P =0. 009) . Conclusion The pathogenic Malassezia flora show different between PV and MF. The polymerase chain reaction-restriction fragment length polymorphism is an accurate and quick method to identify clinical Malassezia species.

  5. 急性痘疮样苔藓样糠疹28例临床分析%Clinical Analysis on 28 Cases of Pityriasis Lichenoides et Varioliformis Acuta

    Institute of Scientific and Technical Information of China (English)

    黄莉宁; 罗光浦; 薛汝增; 谷梅; 刘红芳; 吴铁强; 陈永锋; 顾有守; 杨斌

    2014-01-01

    目的:分析急性痘疮样苔藓样糠疹患者的临床特点及治疗方法。方法:回顾性分析28例急性痘疮样苔藓样糠疹患者的临床资料。结果:28例患者中男18例、女10例,平均年龄(23.9±6.25)岁。10~20岁为好发年龄段(13例)。病程15天至24个月不等。皮损主要表现为出血坏死性丘疹和痘疮样疤痕,主要分布于躯干及四肢,面部、掌跖部位少见。组织病理见坏死角质形成细胞、基底细胞液化变性、真皮内淋巴细胞大致呈楔形浸润。主要治疗方案为口服四环素或红霉素,必要时加雷公藤;病情严重者可静滴甲氨蝶呤。外用药物选择中强效糖皮质激素药膏或卡泊三醇。物理治疗选择补骨脂素光化学疗法(PUVA)或者窄谱中波紫外线。大部分患者按照上述方案组合治疗2~3周后,病情得到控制,皮损数量逐渐减少甚至消失,留有萎缩性疤痕。结论:急性痘疮样苔藓样糠疹的诊断需要临床与病理密切结合,合理的治疗方案可缩短病程。%Objective:To explore the clinical features and treatment of pityriasis lichenoides et varioliformis acuta ( PLEVA) .Methods:Retrospective analysis was performed on the clinical data of 28 patients with PLEVA .Results:The mean age of 28 patients (18 males and 10 females) was 23.9 ±6.25 years with a peak of 10 to 20 years.The clinical course was from 15 days to 24 months.The clinical features of PLEVA were hemorrhagic necrotic papules and varioliform scars . In lesion distribution , the majority of lesions were located on the trunk and limbs .The histopatho-logical features include apoptotic keratinocytes , liquefaction of basal cells , top-heavy and wedge-shaped lymphocyte infiltration .Oral tetracycline or erythromycin is the most effective treatment regimens.If necessary tripterygium wilfordii and methotrexate could be added .Topical corticoste-roids, topical calcipotriol , PUVA ( psoralen

  6. Clinicopathologic analysis of 60 cases of pityriasis lichenoides et varioliformis acuta%急性痘疮样苔藓样糠疹60例临床病理分析

    Institute of Scientific and Technical Information of China (English)

    徐秀莲; 王光平; 陈浩; 姜祎群; 曾学思; 贾虹; 孙建方

    2015-01-01

    目的 探讨急性痘疮样苔藓样糠疹(PLEVA)的临床病理特征.方法 回顾分析60例PLEVA患者的临床和病理资料.结果 60例PLEVA患者中,2~18岁32例(53.3%),19 ~ 49岁28例(46.7%).皮损分布情况:弥漫型50例(83.3%),中心型2例(3.3%),外周型8例(13.4%).发病前有上呼吸道感染史19例(31.6%).组织病理学检查:60例均具有基底细胞液化变性和真皮内血管周围炎改变.角质层内中性粒细胞脓肿26例(43.3%),表皮内坏死角质形成细胞41例(68.3%),发生广泛液化变性30例(50.0%),有淋巴细胞移入表皮43例(71.6%),有Pautrier微脓肿形成者2例,有程度不等的真皮浅层红细胞外溢者46例(76.7%),真皮内有血管壁纤维素样坏死者3例,演变为蕈样肉芽肿1例.20例患者行免疫组化检查,其中3例示T细胞单克隆性增生.结论 PLEVA临床表现有特征性,临床与病理的密切结合是诊断该病的金标准.%Objective To explore the clinicopathologic features of pityriasis lichenoides et varioliformis acuta (PLEVA).Methods A retrospective analysis was performed.Clinical and histological data were collected from 60 patients with PLEVA.The clinicopathologic features of PLEVA were analyzed.Results Among the 60 patients with PLEVA,32 (53.3%) were aged 2-18 years,and 28 (46.7%) aged 19-49 years.Skin lesions were distributed in a diffuse pattern in 50 (83.3%) patients,in a central pattern in 2 (3.3%) patients,and in a peripheral pattern in 8 (13.4%) patients.Nineteen (31.6%) patients had a history of upper respiratory infection.Histopathological examination revealed liquefactive degeneration of basal cells and perivasculitis in the dermis in all the 60 cases,neutrophil abscess formation in the stratum corneum in 26 (43.3%) cases,keratinocyte necrosis in the epidermis in 41 (68.3%) cases,generalized liquefactive degeneration in 30 (50.0%) cases,migration of lymphocytes into the epidermis in 43 (71.6%) cases

  7. PITYRIASIS LICHENOIDES CHRONICA IN A CHILD

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    Iolanda C. Fernandes

    2017-01-01

    Discussion: In general, the typical cutaneous lesions of PLC are asymptomatic and consist of erythematous papules with a central micaceous scale that can easily be detached to reveal a shiny surface (lichenoid. It usually resolves spontaneously following a long period of remissions and recurrences. The treatment options include topical and oral corticosteroids, oral erythromycin and heliotherapy, among others.

  8. Therapeutic effect of desloratadine citrate disodium tablets combined with narrow band ultraviolet B in the treatment of pityriasis rosea%枸地氯雷他定联合窄谱中波紫外线治疗玫瑰糠疹疗效观察

    Institute of Scientific and Technical Information of China (English)

    闫锐; 徐爱国; 黄晨

    2015-01-01

    Objective To observe the clinical efficacy of desloratadine citrate disodium tablets combined with narrow band ultraviolet B in the treatment of pityriasis rosea.Methods According to the digital table,88 pityriasis rosea patients were randomly divided into the two groups.45 cases of the study group were treated by desloratadine citrate disodium tablets combined with narrow ultraviolet B,43 cases of the control group were treated by desloratadine citrate disodium tablets alone.The both two groups applied Binghuangfule cream.The therapeutic effect and safety of the two groups were compared.Results The cure rate in study group was 71.11%,which of the control group was 51.16%,the difference was not statistically significant (x2 =3.69,P > 0.05).The effective rate of the treatment group was 91.11%,which of the control group was 69.77%,the difference between the two groups was statistically significant (x2 =6.43,P < 0.05).Conclusion The result reveals that desloratadine citrate disodium tablets combined with narrow band ultraviolet B is more effective and worthy to be used in clinical practice.%目的 观察枸地氯雷他定口服联合窄谱中波紫外线(NB-UVB)照射治疗玫瑰糠疹的疗效.方法 选择88例玫瑰糠疹患者,采用随机数字表法分为两组.治疗组45例采用口服枸地氯雷他定联合NB-UVB照射,对照组43例口服枸地氯雷他定,两组均外用冰黄肤乐软膏.观察两组的治疗效果和安全性.结果 治疗组痊愈率71.11%,有效率91.11%;对照组痊愈率51.16%,有效率69.77%,治疗组痊愈率优于对照组,但差异无统计学意义(x2=3.69,P>0.05);两组有效率差异有统计学意义(x2 =6.43,P<0.05).结论 枸地氯雷他定联合NB-UVB照射治疗玫瑰糠疹安全有效,值得临床推广应用.

  9. Treatment of pityriasis versicolor with topical application of essential oil of Cymbopogon citratus (DC Stapf - therapeutic pilot study Tratamento de pitiríase versicolor com aplicação tópica do óleo essencial de Cymbopogon citratus (DC Stapf - estudo terapêutico piloto

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    Egberto Santos Carmo

    2013-06-01

    Full Text Available BACKGROUND: Pityriasis versicolor is a fungal infection caused by Malassezia spp. that has frequent relapses. OBJECTIVES: The main objective of this research was to perform phase I and II clinical studies, using formulations containing essential oil of Cymbopogon citratus in patients with pityriasis versicolor. METHODS: Phase I study included twenty volunteers to ascertain the safety of the formulations. In phase II, 47 volunteers randomly received essential oil formulations at 1.25 μL/mL concentration, for forty days. The shampoo should be applied three times a week and the cream twice a day. A control group in phase II, consisting of 29 volunteers, received the same formulations but with 2% ketoconazole as the active ingredient. RESULTS: No significant adverse events were observed in volunteers during Phase I. In Phase II, 30 (63.83% volunteers using essential oil and 18 (62.07% using ketoconazole remained until the end of the study. We observed a predominance of lesions in disseminated form, with M. sympodialis detected as the predominant agent identified in cultures. After 40 days of treatment, the rate of mycological cure was 60% (p FUNDAMENTOS: Pitiríase versicolor é uma micose causada pela Malassezia spp., e que apresenta frequentes recidivas. OBJETIVOS: Este trabalho objetivou realizar estudos clínicos de fase I e II, para essa patologia, com óleo essencial de Cymbopogon citratus. MÉTODOS: Na fase I, participaram vinte voluntários para averiguar a segurança das formulações. Na fase II, 47 voluntários receberam as formulações do óleo essencial a 1,25 μL/mL, as quais deveriam ser utilizadas por quarenta dias, sendo o xampu três vezes por semana e o creme duas vezes ao dia. Um grupo controle na fase II, constituído por 29 voluntários recebeu as mesmas formulações, com cetoconazol a 2%. RESULTADOS: Verificada a segurança das formulações com a finalização da fase I, onde nenhuma reação adversa significativa foi

  10. Clinical efficacy of combined therapy of narrow-band ultraviolet B and 2% ketoconazole lotions for pityriasis versicolor%NB-UVB 联合2%酮康唑洗剂治疗花斑糠疹疗效观察

    Institute of Scientific and Technical Information of China (English)

    刘志超; 马凌云; 孙心君; 闫建军

    2016-01-01

    目的:观察窄谱中波紫外线(NB-UVB)联合2%酮康唑洗剂治疗花斑糠疹的临床疗效。方法120例花斑糠疹患者随机分为3组,A 组:单纯使用2%酮康唑洗剂外洗治疗,每日1次;B 组:NB-UVB 照射治疗,隔日照射1次;C 组:NB-UVB 与2%酮康唑洗剂联合治疗,方法分别与 A 组、B 组相同。治疗后4周观察3组患者皮疹消退的时间及真菌学检查结果并总结疗效。结果 A 组皮损消退的时间为(18.56±2.25)d,有效率72.5%;B 组患者照射次数为(6.28土1.37)次,累积照射剂量为(3619±697)mJ/ cm2,皮损消退的时间为(10.32±2.19)d,有效率77.5%;C 组患者照射次数为(3.77土1.52)次,累积照射剂量为(2152±889)mJ/ cm2,皮损消退的时间为(6.46±2.14)d,有效率97.5%;C 组皮损消退时间及有效率明显高于 A 组和 B 组(P <0.05)。结论 NB-UVB 联合2%酮康唑洗剂治疗花斑糠疹具有起效快、疗效高等优点,值得临床推广、应用。%Objective To observe the clinical efficacy of the combined therapy of narrow-band ultraviolet B and 2% ketoconazole lotions for Pityriasis versicolor. Methods One hundred and twenty patients with Pity-riasis versicolor were involved in this study. They were randomly divided into three groups and treated by dif-ferent therapies,respectively. Group A(40 patients)was only treated with 2% ketoconazole lotions,Group B (40 patients)only with narrow-band ultraviolet B,Group C(40 patients)with the combined therapy of nar-row-band ultraviolet B and 2% ketoconazole lotions. The average deflorescence duration and the result of mycology examination were analyzed. Results The average deflorescence duration was 18. 56 ± 2. 25 days, 10. 32 ± 2. 19 days and 6. 46 ± 2. 14 days in Group A,B and C,respectively. The effective rate was 72. 5% , 77. 5% and 97. 5% in Group A,B and C,respectively. The results of group comparison showed that there

  11. Aspectos clínicos de pacientes com pitiríase versicolor atendidos em um centro de referência em dermatologia tropical na cidade de Manaus (AM, Brasil Clinical aspects of patients with pityriasis versicolor seen at a referral center for tropical dermatology in Manaus, Amazonas, Brazil

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    Patrícia Motta de Morais

    2010-12-01

    Full Text Available FUNDAMENTOS: A pitiríase versicolor (tinha versicolor é uma micose superficial crônica, causada por leveduras do gênero Malassezia spp. comensais das camadas queratinizadas da pele e que, sob determinadas condições ainda não esclarecidas, se torna patogênica, determinando as manifestações clínicas da doença. É uma dermatose recidivante e, mesmo após tratamento, pode deixar hipopigmentação persistente, causando problemas sociais aos indivíduos acometidos. OBJETIVO: Descrever as características clínicas e epidemiológicas de pacientes com diagnóstico de tinha versicolor atendidos em uma unidade de referência em Dermatologia (Fundação Alfredo da Matta. MÉTODOS: Estudo de série de casos em que foram detalhadas as manifestações cutâneas e as características epidemiológicas de pacientes atendidos na Fundação Alfredo da Matta com diagnóstico de tinha versicolor. RESULTADOS: Cento e dezesseis pacientes foram incluídos no estudo no período de janeiro a agosto de 2008. A maioria dos indivíduos é do sexo masculino, de cor parda, da faixa etária jovem e formada por estudantes, que apresentavam fatores predisponentes ao surgimento das manchas. Também a maioria apresentava lesões extensas e história passada da doença. CONCLUSÃO: O estudo mostrou alta proporção de indivíduos com quadros extensos e de longa duração da doença.BACKGROUND: Pityriasis versicolor (tinea versicolor is a chronic superficial mycosis caused by yeasts of the Malassezia spp. genus commensal of the keratinized layers of the skin. Under conditions not yet understood, it becomes pathogenic determining the clinical manifestations of the disease. It is a recurrent skin condition and persistent hypopigmentation may remain after treatment, causing social problems to those affected. OBJECTIVE: To describe the clinical and epidemiological features of patients diagnosed with tinea versicolor treated at a referral center for dermatology (Alfredo da

  12. Pityriasis versicolor: clinical-epidemiological characterization of patients in the urban area of Buerarema-BA , Brazil Pitiríase versicolor: caracterização clínico-epidemiológica em pacientes da área urbana de Buerarema-BA, Brasil

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    Juliano Oliveira Santana

    2013-04-01

    Full Text Available BACKGROUND: Pityriasis versicolor (PV is a cutaneous pigmentation disorder caused by a lipophilic yeast of the genus Malassezia sp. It is a superficial mycosis characterized by well-defined, slightly scaly skin lesions of variable color. In Brazil, the number of reported cases is small, and there are few epidemiological studies. OBJECTIVES: to assess incidence, characteristics of the lesions, effectiveness of the Zileri's Sign procedure, and the epidemiological profile of PV in the urban area of Buerarema - Bahia. METHODS: Biological samples were collected on pre-established days at Basic Health Care Units from July to September 2010. Sample collection was followed by laboratory diagnosis using Porto's Method. RESULTS: Of the 158 patients with suspected PV participating in the study, 105 (66.5% were positive; 72 (68.6% were female and 33 (31.4% were male. Sex and location of lesions showed statistically significant differences (p FUNDAMENTOS: A pitiríase versicolor é um distúrbio de pigmentação cutânea causada pela levedura lipofílica do gênero Malassezia sp. É uma micose superficial caracterizada por produzir lesões delimitadas, com descamação fina e de cor variável. No Brasil, o relato do número de casos e de estudos é restrito. OBJETIVOS: Analisar a incidência, as características das lesões, a eficácia do Sinal de Zileri e o perfil epidemiológico da pitiríase versicolor na área urbana do município de Buerarema-BA. MÉTODOS: Foram coletadas amostras biológicas no período de julho a setembro de 2010, em dias pré-establecidos, nas Unidades Básicas de Saúde. O Método de Porto foi utilizado como diagnóstico laboratorial. RESULTADOS: Dos 158 pacientes cadastrados com suspeita de pitiríase versicolor, 105 (66,5% mostraram-se positivos, sendo 72 (68,6% do sexo feminino e 33 (31,4% do sexo oposto. Ocorreu diferença estatisticamente significante entre sexo e localização das lesões (p<0,05. A região com maior

  13. Keratinocyte detachment-differentiation connection revisited, or anoikis-pityriasi nexus redux.

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    Tomohiro Banno

    Full Text Available Epidermis, a continuously self-renewing and differentiating organ, produces a protective stratum corneum that shields us from external chemical, physical and microbial threats. Epidermal differentiation is a multi-step process regulated by influences, some unknown, others insufficiently explored. Detachment of keratinocytes from the basement membrane is one such pro-differentiation stimulus. Here, we define the transcriptional changes during differentiation, especially those caused by detachment from the substratum. Using comprehensive transcriptional profiling, we revisited the effects of detachment as a differentiation signal to keratinocytes. We identified the genes regulated by detachment, the corresponding ontological categories and, using metaanalysis, compared the genes and categories to those regulated by other pro-differentiating stimuli. We identified 762 genes overexpressed in suspended keratinocyte, including known and novel differentiation markers, and 1427 in attached cells, including basal layer markers. Detachment induced epidermis development, cornification and desmosomal genes, but also innate immunity, proliferation inhibitors, transcription regulators and MAPKs; conversely the attached cells overexpressed cell cycle, anchoring, motility, splicing and mitochondrial genes, and both positive and negative regulators of apoptosis. Metaanalysis identified which detachment-regulated categories overlap with those induced by suprabasal location in vivo, by reaching confluency in vitro, and by inhibition of JUN kinases. Attached and in vivo basal cells shared overexpression of mitochondrial components. Interestingly, melanosome trafficking components were also overexpressed in the attached and in vivo basal keratinocytes. These results suggest that specific pro-differentiation signals induce specific features of the keratinization process, which are in vivo orchestrated into harmonious epidermal homeostasis.

  14. Keratinocyte detachment-differentiation connection revisited, or anoikis-pityriasi nexus redux.

    Science.gov (United States)

    Banno, Tomohiro; Blumenberg, Miroslav

    2014-01-01

    Epidermis, a continuously self-renewing and differentiating organ, produces a protective stratum corneum that shields us from external chemical, physical and microbial threats. Epidermal differentiation is a multi-step process regulated by influences, some unknown, others insufficiently explored. Detachment of keratinocytes from the basement membrane is one such pro-differentiation stimulus. Here, we define the transcriptional changes during differentiation, especially those caused by detachment from the substratum. Using comprehensive transcriptional profiling, we revisited the effects of detachment as a differentiation signal to keratinocytes. We identified the genes regulated by detachment, the corresponding ontological categories and, using metaanalysis, compared the genes and categories to those regulated by other pro-differentiating stimuli. We identified 762 genes overexpressed in suspended keratinocyte, including known and novel differentiation markers, and 1427 in attached cells, including basal layer markers. Detachment induced epidermis development, cornification and desmosomal genes, but also innate immunity, proliferation inhibitors, transcription regulators and MAPKs; conversely the attached cells overexpressed cell cycle, anchoring, motility, splicing and mitochondrial genes, and both positive and negative regulators of apoptosis. Metaanalysis identified which detachment-regulated categories overlap with those induced by suprabasal location in vivo, by reaching confluency in vitro, and by inhibition of JUN kinases. Attached and in vivo basal cells shared overexpression of mitochondrial components. Interestingly, melanosome trafficking components were also overexpressed in the attached and in vivo basal keratinocytes. These results suggest that specific pro-differentiation signals induce specific features of the keratinization process, which are in vivo orchestrated into harmonious epidermal homeostasis.

  15. 茄子佐治花斑癣%Using Eggplant in Axilliary to Treat Pityriasis Versicolor

    Institute of Scientific and Technical Information of China (English)

    谷杰法

    2001-01-01

    用硫磺、雄黄等份,研末,将鲜茄子横断,以切面蘸硫磺、雄黄末在患处反复摩擦,每日2~3次,每次约半小时,10日为1个疗程。此乃民间治疗花斑癣(汗斑)验方。笔者试用此法治疗花斑癣数例,皆在10日内痊愈,疗效满意。

  16. [Labor epidural analgesia for a woman with a pityriasis versicolor in the lumbar region].

    Science.gov (United States)

    Dubar, G; Omarjee, M; Viguié, C; Barbarot, S; Mignon, A

    2011-01-01

    Epidural analgesia is usually contraindicated in case of infection at the site of needle insertion. Tinea versicolor is a benign superficial cutaneous fungal infection caused by the proliferation of a skin commensal yeast of low pathogenicity. We report the case of a pregnant woman with a tinea versicolor in the lumbar region, who benefited from a labor epidural analgesia, realised with reinforced antiseptic measures. No neurological or infectious complication occurred.

  17. Pityriasis lichenoides et varioliformis acuta%急性痘疮样苔藓状糠疹

    Institute of Scientific and Technical Information of China (English)

    徐素芹; 丁政云; 高顺强; 林元珠; 张增强; 李彦群

    2004-01-01

    患者男,51岁。主诉:全身红斑、丘疹、水疱、鳞屑伴瘙痒1个月余。现病史:1个月前无明显诱因在腹部、背部出现散在的红斑、丘疹伴瘙痒。当地卫生院诊断为过敏性皮炎,给予马来酸氯苯那敏、维生素C口服,外用曲安奈德尿素软膏等治疗,无明显疗效,皮疹逐渐增多,渐波及全身。既往身体健康,无类似皮疹史。家族中亦无类似患者。

  18. 局限型慢性苔藓样糠疹%A case of localized pityriasis lichenoides chronica

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    谭城; 朱文元; 闵仲生

    2009-01-01

    报告1例局限型慢性苔藓样糠疹.患者女,28岁.左肘关节屈侧反复出现瘙痒性红色斑丘疹、鳞屑3年.皮肤科检查:左肘关节屈侧及附近皮肤见红斑、斑丘疹及鳞屑,其中夹杂有色素减退斑、瘢痕.皮损组织病理检查示表皮角化过度,局灶性角化不全和轻度海绵水肿;真皮浅层血管扩张充血明显,红细胞外渗,血管周围少量淋巴细胞浸润.根据临床和组织病理特点,诊断为局限型慢性苔藓样糠疹.

  19. [Clinical trial of a topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil and sodium pyruvate, in several hyperkeratotic skin conditions].

    Science.gov (United States)

    Ferrando, J

    1986-01-01

    A topical clinical trial with preparations containing urea and sodium pyruvate has been made. It was used for diverse hyperkeratotic skin conditions (psoriasis, xerosis, pityriasis rubra pilaris, stuccokeratosis, seborrheic dermatitis, stasis dermatitis, pityriasis lichenoides chronica). A month later a clinical improvement was evident in all cases except in pityriasis lichenoides.

  20. 汗斑患者马拉色菌流行病学资料分析%Epidemiologic analysis of Malassezia in pityriasis versicolor

    Institute of Scientific and Technical Information of China (English)

    陶诗沁; 陈炜; 张海萍; 胡素泉; 陈伟; 沈永年; 杨莉佳; 刘维达

    2005-01-01

    为了解马拉色菌各种类在汗斑患者中的分布情况,笔者使用Leeming-Norman培养基培养马拉色菌镜检阳性的汗斑患者皮肤样本,然后分离菌株进行菌种鉴定。

  1. 急性痘疮样苔藓样糠疹1例%A case of pityriasis lichenoides of rarioliformis acuta

    Institute of Scientific and Technical Information of China (English)

    任昊远; 彭少文; 李俊

    2011-01-01

    @@ 临床资料 患者,男,30岁.主因躯干、四肢起皮疹1天,于2011年1月2日就诊.患者1天前无明显诱因,躯干、四肢出现红斑、丘疹、丘疱疹,无明显自觉症状,逐渐增多,遂来我科就诊.患者起病以来,无畏寒发热,腹痛、腹泻等症状.患者平素体健,家族中均无类似疾病史.

  2. 急性痘疮样苔藓样糠疹1例%A Case of Pityriasis Lichenoides et Varioliformis Acuta

    Institute of Scientific and Technical Information of China (English)

    何磊; 党林; 栗玉珍

    2012-01-01

    Objective To understand the clinical features of eosinophilic pustular folliculitis ( EPF). Methods We reported an EPF patient and performed the clinical analysis for all the patients published in Chinese journals in recent ten years. Results There were 19 males and 1 female in these patients. EPF is a rare dermatosis characterized by recurrent outbreaks of papulopustular skin lesions mainly distributed in seborrheic areas ( mainly on the face, upper back, and upper extremities. ) as annular form. EPF could be associated with AIDS. We found that peripheral blood eosinophils increasing in 15 cases and non-increasing in 5 cases. Conclusion The incidence of EPF in male is higher than that in females. There are different clinical features in different patients. EPF could be accompanied with the increasing of peripheral blood eosinophils.%患者女,48岁.周身泛发性红色丘疹、丘疱疹伴瘙痒10余日,皮疹多为粟粒至黄豆大小,上覆少许薄鳞屑,Ausptiz征(-),部分皮损破溃、坏死、血痂.皮损组织病理示:表皮细胞间水肿及细胞内水肿形成多房性表皮内疱,疱内见中性粒细胞及多量红细胞,基底细胞液化,区域性淋巴样细胞浸润.诊断:急性痘疮样苔藓样糠疹.

  3. 局部用药治疗慢性苔藓样糠疹1例%Local treatment of pityriasis lichenoides chronica:A case report

    Institute of Scientific and Technical Information of China (English)

    张国毅; 曾学思

    2000-01-01

    @@ 1 临床资料:患者男性,22岁.因四肢、躯干起淡红褐色丘疹10年就诊.10年前无明显诱因发现双上肢起米粒大淡褐色、淡红色皮损,多数与皮肤一样平,仅少数皮损稍高出皮面,不痒、不痛.半年后发现胸、背、下肢亦有类似皮损.随年龄增长皮损缓慢扩大,从无消退现象,数量上增加不甚明显,但颜色缓慢逐渐加深,部分呈灰褐色.

  4. 急性痘疮样苔藓样糠疹1例%A case of pityriasis lichenoides et varioliformis acuta

    Institute of Scientific and Technical Information of China (English)

    王连祥

    2010-01-01

    @@ 临床资料 患儿,男,3岁.主因全身出现红斑、丘疹伴瘙痒1月余,于2009年6月11日来我院就诊.1个月前患儿无明显诱因背部出现红斑、丘疹,渐累及全身,且出现水疱、脓疱、结痂,自觉瘙痒,外涂"糠酸莫米松乳膏"后症状稍缓减,但停药后加重.既往健康,否认家族成员有类似病史.

  5. PERBEDAAN SKIN CAPACITANCE DAN TRANSEPIDERMAL WATER LOSS PADA KULIT NON-LESI PASIEN PITIRIASIS VERSIKOLOR DENGAN NON-PITIRIASIS VERSIKOLOR

    Directory of Open Access Journals (Sweden)

    Satya Wydya Yenny

    2008-09-01

    Full Text Available AbstrakPada pitiriasis versikolor sering timbul kekambuhan, diduga salah satu penyebabnya adalah kelembaban kulit yang tinggi. Kelembaban kulit dipengaruhi oleh skin capacitance dan transepidermal water loss.Mengetahui skin capacitance dan transepidermal water loss kulit pasien pitiriasis versikolor dan perbedaannya dengan non-pitiriasis versikolor.Penelitian ini merupakan studi potong lintang perbandingan antar kelompok, yang dilakukan pada bulan September sampai dengan Nopember 2004 di Rumah Sakit Dr. Cipto Mangunkusumo. Subyek penelitian pasien pitiriasis versikolor dan kontrol non-pitiriasis versikolor yang dipasangkan dalam hal umur dan jenis kelamin dan dilakukan pemeriksaan skin capacitance dan transepidermal water loss pada kulit yang tampak normal di punggung menggunakan alat Tewameter/Corneometer 350.Dalam kurun waktu tersebut telah diperiksa sebanyak 32 pasien pitiriasis versikolor dan 32 kontrol non-pitiriasis versikolor. Skin capacitance pasien pitiriasis versikolor secara statistik tidak berbeda dengan kontrol non-pitiriasis versikolor (p = 0,730. Transepidermal water loss pasien pitiriasis versikolor secara bermakna lebih rendah dari pada kelompok kontrol non-pitiriasis versikolor (p = 0,000.Tidak ada perbedaan skin capacitance kulit pasien pitiriasis versikolor dengan non-pitiriasis versikolor. Transepidermal water loss kulit pasien pitiriasis versikolor lebih rendah daripada non-pitiriasis versikolor.Kata kunci: pitiriasis versikolor, skin capacitance, transepidermal water lossAbstractThe recurrence of pityriasis versicolor is high, it could be caused by high skin hydration. Skin hydration was influenced by skin capacitance and transepidermal water loss.ARTIKEL PENELITIAN168The purpose of this study was to compare the differences of the skin capacitance and transepidermal water loss between the pityriasis versicolor skin and healthy non-pityriasis versicolor skin.The design of this study was comparative cross-sectional study

  6. Treatment of pityriasis versicolor with itraconazole in combination with butenafine cream and ketoconazole lotion:a clinical study%伊曲康唑联合外用药物治疗花斑糠疹临床研究

    Institute of Scientific and Technical Information of China (English)

    岳喜昂; 刘卫兵; 陈洪晓; 杨华

    2010-01-01

    目的 探讨伊曲康唑胶囊联合1%盐酸布替萘芬乳膏和2%酮康唑洗剂治疗花斑糠疹的疗效及不良反应.方法 入选患者按单双日分为两组,两组均口服伊曲康唑0.2 g,1次/d,连续7 d,同时外用1%盐酸布替萘芬乳膏,1次/d,连续14d,对照组停药观察,试验组同时使用2%酮康唑洗剂洗浴,每周2次,连用3个月.分别于治疗前、治疗后1、3、6、12个月评价疗效.结果 试验组114例患者3个月时痊愈率78.1%,6个月时痊愈率90.4%,对照组125例患者3个月时痊愈率72.8%,6个月时痊愈率75.2%,12个月后试验组复发率1.8%,对照组为18.4%.结论 伊曲康唑胶囊短时口服联合外用布替萘芬和酮康唑洗剂洗浴疗效较好,安全性高,使用方便,可大大降低花斑糠疹的复发率.

  7. Treatment Effect of Naftifine/Ketoconazole Cream to Pityriasis Versicolor in Children%萘替芬酮康唑乳膏治疗儿童花斑糠疹的疗效观察

    Institute of Scientific and Technical Information of China (English)

    熊心猜; 张浩; 丁小洁; 刘婷; 邓利丽; 侯秀芹

    2011-01-01

    目的:观察萘替芬酮康唑乳膏治疗儿童花斑糠疹的疗效及安全性。方法:129例儿童花斑糠疹患儿随机分为两组,治疗组67例,对照组62例,两组在病程、性别、年龄上无统计学差别;治疗组每天外搽萘替芬酮康唑乳膏2次,对照组外搽酮康唑乳膏2次,两组疗程均6周。于治疗前、治疗结束后分别记录患儿皮损情况、真菌检查及有无不良反应。结果:治疗组的有效率为92.54%,对照组的有效率为74.19%,治疗组和对照组比较疗效有统计学差异。治疗组的真菌清除率为98.51%,对照组的真菌清除率为90.32%,治疗组和对照组真菌清除率比较有统计学差异。两组患儿均无明显不良反应发生。结论:萘替芬酮康唑乳膏治疗儿童花斑糠疹安全有效。

  8. 伊曲康唑巩固疗法降低花斑癣复发率的临床研究%A comparative clinical study of the consolidation treatment of itraconazole in pityriasis versicolor

    Institute of Scientific and Technical Information of China (English)

    王亚平; 刘金昌; 刘良传; 滕蔚

    2006-01-01

    目的:探讨一种能够降低花斑癣复发率的有效治疗方案.方法:将初诊的花斑癣患者按就诊时间分为两组,均口服伊曲康唑0.2 g,每日1次,连续服药7 d.7 d后对照组停药观察,试验组则继续服用伊曲康唑,每月口服0.2 g 1次,共6个月.两组患者皆每月复诊1次,共6次.结果:试验组99例患者复发率为1.01%,治愈率为85.86%.对照组95例患者复发率为17.89%,治愈率为64.21%.经卡方检验两组患者的复发率及治愈率相比,差异均有极显著性(x2=16.419 5,P=0.000 1和x2=12.201 3,P=0.0005).结论:巩固治疗方案能在近期内降低花斑癣复发率,同时提高花斑癣的治愈率.

  9. 花斑糠疹和马拉色菌毛囊炎菌种分布特点分析%Distribution of Malassezia species in Pityriasis Versicolor and Malassezia Folliculitis

    Institute of Scientific and Technical Information of China (English)

    李智华; 耿承芳; 江清; 金云; 占萍; 陶丽; 罗云鹏

    2010-01-01

    目的 探讨花宽糠疹和马拉色茵毛囊炎的菌种分布特点.方法 从临床诊断为花斑糠疹和马拉色茵毛囊炎的患者分离培养菌种,通过形态学和生理生化学方法鉴定菌种,并比较两组患者茵种分布情况.结果 共收集花斑糠疹病例161例,培养阳性121株,其中合轴马拉色茵46株,糠秕马拉色茵13株,球形马拉色茵29株,钝性马拉色茵33株;马拉色茵毛囊炎135例,培养阳性114株,其中合轴马拉色茵52株,糠秕马拉色茵43株,球形马拉色茵13株,钝性马拉色茵6株.两种疾病茵种分布差异有显著性(P<0.005).结论 花斑糠疹和马拉色茵毛囊炎茵种分布存在差异,可能为两种疾病不同临床表现的原因之一,但结果尚需慎重解释,需要分子水平的进一步研究.

  10. Observation on Curative Effect of Uigurian Medicine in Treating 610 Cases Suffered from Pityriasis Versicolor alba%维吾尔医治疗白癜风610例的临床观察

    Institute of Scientific and Technical Information of China (English)

    吐尔逊·吾甫尔; 艾尼瓦尔·加马力

    2003-01-01

    目的:初步观察维吾尔医对白癜风疗效;方法:饮食忌口、成熟清除疗法、调节气质、治疗白癜风的专用药物和补药、日光浴和外用药物等作为白癜风的治疗方法;结果:治疗白癜风患者610例,治愈率19.34%,显效36.22%,有效40.98%,无效3.44%.总有效率96.54%.结论:维吾尔医学治疗白癜风有明显的疗效.

  11. Preliminary Study on the Pigmentogenesis of Malassezia in Pityriasis Versicolor%马拉色菌与花斑癣色素改变的相关性初探

    Institute of Scientific and Technical Information of China (English)

    陶诗沁; 陈炜; 杨莉佳; 陈伟; 张海萍; 吕桂霞; 刘维达

    2005-01-01

    目的探讨马拉色菌与花斑癣皮疹色素改变及色氨酸产色三者之间的关系.方法从花斑癣患者皮损分离马拉色菌株,采用国际通用的生化鉴定方法鉴定,然后在不同浓度L-色氨酸的培养基上培养7 d,观察产色反应.结果每个菌种均有产色反应阳性和阴性菌株,产色反应阳性菌株更易引起皮损色素沉着(P<0.005),且产色反应阳性标本颜色按色氨酸浓度递减而变淡.结论菌株的产色反应与马拉色菌的种属分类无必然的联系,色氨酸参与了马拉色菌产色反应.

  12. Comparison of Treatment Effect of Naftifine /Ketoconazole Cream and Clotrimazole Cream to Pityriasis Versicolor%萘替芬酮康唑乳膏与克霉唑乳膏治疗花斑癣的疗效对比

    Institute of Scientific and Technical Information of China (English)

    翟慧娟

    2013-01-01

    目的 分析萘替芬酮康唑乳膏治疗花斑癣患者的疗效.方法 随机将138例花斑癣患者分为两组(实验组72例,对照组66例),两组在性别、年龄、病程上无统计学差异,前组患者涂搽萘替芬酮康唑乳膏,2次/d,后组患者涂搽克霉唑乳膏,2次/d,两组疗程均为6周.分别记录患者的治疗前和治疗结束后真菌检查、皮损情况及不良反应.结果 治疗组的真菌清除率为98.61%,有效率为93.06%;对照组的真菌清除率为90.91%,有效率为72.73%,两组比较疗效有统计学差异(P﹤0.05),两组患者均无明显不良反应.结论 萘替芬酮康唑乳膏治疗花斑糠疹患者安全有效.

  13. Clinical histopathological and ultrastructural manifestations of pityriasis lichenoides et varioliformis acuta%急性痘疮样苔藓样糠疹临床、病理及免疫组化分析

    Institute of Scientific and Technical Information of China (English)

    张红; 笪继平; 王萍; 赵广; 孟如松

    2006-01-01

    目的:探索急性痘疮样苔藓样糠疹(PLEVA)的病因,寻求有效治疗方法.方法:对我院12年中11例PLEVA患者的临床表现、组织病理、免疫组化及超微结构进行回顾性分析.结果:①本组临床表现为全身泛发出血性丘疹为主的多形性皮疹;②组织病理及超微结构:以淋巴细胞性血管炎,淋巴细胞、红细胞游入表皮为特征;③目前治疗以皮质类固醇激素、非甾体抗炎剂、环孢素较为有效.结论:环孢素可能是治疗重症PLEVA的有效药物.

  14. 急性痘疮样苔藓样糠疹1例及文献回顾%One Case with Pityriasis Lichenoides et Varioliformis Acuta and Literature review

    Institute of Scientific and Technical Information of China (English)

    王于斌

    2012-01-01

    患者男,12 岁,躯干、四肢、臀部及腋窝散在分布较多粟粒至黄豆大小暗红色丘疹2 月余,部分丘疹表面附有细碎鳞屑,部分丘疹有脓疱、坏死及结痂,新旧皮疹同时存在.患者无发热及全身浅表淋巴结肿大.组织病理示:表皮灶性坏死,局部基底细胞液化变性,真皮毛细血管周围淋巴细胞浸润.诊断:急性痘疮样苔藓样糠疹.本文从发病机制、临床表现、组织病理、鉴别诊断和治疗等方面进行了文献回顾和复习.

  15. One Case with Pityriasis Lichenoides et Varioliformis Acuta and Literature Review%急性痘疮样苔藓样糠疹1例及文献复习

    Institute of Scientific and Technical Information of China (English)

    孙仁山; 朱堂友; 成琼辉; 伍津津; 吴先林; 李文维

    2010-01-01

    患者男,47岁,躯干、四肢皮肤见泛发粟粒至黄豆大红色斑丘疹20天,丘疹上覆少许稀薄鳞屑,Auspit 征(-),部分皮损中央破溃,坏死、结痂.患者无发热、淋巴结及肝脾肿大.组织病理示:表皮呈灶性变性坏死,区域性淋巴浸润.诊断:急性痘疮样苔藓样糠疹.本文并就其病因、临床表现、病理进展和治疗进行了文献复习.

  16. Assessment of allelopathic potential of Cassia sophera L. on ...

    African Journals Online (AJOL)

    ufuoma

    2014-02-26

    Feb 26, 2014 ... resistant weeds and human health problems, make it necessary to ... treatment of pityriasis, psoriasis, asthma, acute bronchitis, cough ... four digital balance of Scientech, Model ZSA 120, Colorado (USA). The leaf area was ...

  17. 苔藓样糠疹

    Institute of Scientific and Technical Information of China (English)

    冯素英; 靳培英

    2009-01-01

    @@ 苔藓样糠疹(pityriasis lichenoides)有三种不同的类型,分别为发热溃疡坏死性苔藓样糠疹(pityriasis lichenoides with ulceronecrotic hyperthermia,PLUH)、急性苔藓痘疮样糠疹(pityriasis lichenoides et varioliformis acuta,PLEVA)、慢性苔藓样糠疹(pityriasis lichenoides chronica,PLC).在三型之间有一些移行状态,分别具有不同亚型的特点,说明这三种亚型之间是有联系的,一些患者可以同时有PLEVA和PLC的皮损表现.

  18. CLINICO - MYCOLOGICAL STUDY OF SUPERFICIAL FUNGAL INFECTIONS IN COASTAL KARNATAKA, INDIA

    Directory of Open Access Journals (Sweden)

    Sweta R.

    2013-10-01

    Full Text Available ABSTRACT: Cutaneous fungal infections are common in coastal Karnataka owing to its tropical and humid climate. The organisms causing these infections commonly are dermatophytes, non dermatophytes and yeasts. This study aims to determine the p revalence of cutaneous mycosis, with their different clinical types and etiological agents, and correlate the findings. A total of 96 patients were included in our study, all of them attending dermatology OPD at a tertiary hospital in Mangalore with clinic ally suspected tinea corporis, tinea cruris, tinea pedis, tinea capitis, tinea mannum, onychomycosis, candidiasis and pityriasis versicolor. The study revealed male to female ratio being 0.74:1. The leading diagnosis was pityriasis versicolor, the commones t organism isolated was C. albicans; and the commonest site involved is groin and skin flexures. This study emphasizes utility of timely detection of cutaneous fungal infection in preventing transmission and spread of KEYWORDS: Fungal infe ctions; Dermatophytes; Pityriasis versicolor such infections

  19. Parapsoriasis: a complex issue.

    Science.gov (United States)

    Sehgal, Virendra N; Srivastava, Govind; Aggarwal, Ashok K

    2007-01-01

    Parapsoriasis is a peculiar reaction pattern of the skin that appears to have a spectrum with small plaque parapsoriasis at one end and large plaque at the other. The spectrum between is bridged by pityriasis lichenoides, pityriasis lichenoides chronica, pityriasis lichenoides et varioliformis acuta, and lymphomatoid papulosis. The highlights of the clinical pattern of these diseases has been succinctly elucidated here to facilitate their recognition in day-to-day dermatologic practice. Their possible etiopathogenesis has been brought to focus in the light of changing concepts reported in the literature. Further, possible future implications demand a meticulous follow-up because, in a few cases, true neoplasms may ultimately develop. Treatment modalities are briefly discussed.

  20. Identificação de espécies de malassésia na pitiríase versicolor em um serviço de dermatologia do sul do Brasil Identification of Malassezia yeast species isolated from patients with pityriasis versicolor

    Directory of Open Access Journals (Sweden)

    Vanessa Petry

    2011-08-01

    Full Text Available A pitiríase versicolor é uma doença de distribuição universal. Existe a descrição de 12 espécies de malassezia. O objetivo deste estudo foi determinar quais as espécies de malassezia mais prevalentes nos pacientes com pitiríase versicolor. Foram realizadas as coletas através de raspado das lesões nos pacientes com suspeita clínica de pitiríase versicolor e posterior exame micológico e cultural para identificação final da espécie. Foram coletadas amostras de 87 pacientes. Quanto às culturas, 30% foram de Malassezia sympodialis, 25,7% de Malassezia furfur, 22,7% de Malassezia globosa, 12,1% de Malassezia retrita, 7,6% de Malassezia obtusa e 1,5% de Malassezia sloofiae

  1. Clinical Observation of 65 Cases Treated with Naftifine Hydrochloride and Ketoconazole Cream Combined with Adapalene in Pityriasis Versicolor%萘替芬酮康唑乳膏联合阿达帕林凝胶治疗花斑糠疹65例临床观察

    Institute of Scientific and Technical Information of China (English)

    史天威; 任晓坤; 张江安; 余红星; 于建斌

    2014-01-01

    目的 评价萘替芬酮康唑乳膏联合阿达帕林凝胶治疗花斑糠疹的临床疗效及安全性.方法 将入选的65例花斑糠疹患者随机分为2组,治疗组予萘替芬酮康唑乳膏和阿达帕林凝胶外,对照组予萘替芬酮康唑乳膏外用,疗程均为2周,分别于治疗结束时及结束后2周时比较两组患者的真菌清除率及临床疗效.结果 治疗结束时和治疗结束后2周时,治疗组的有效率为84.85%和96.97%,对照组为62.50%和75.00%,差异均有统计学意义(P均<0.05).且两组患者中均未见严重不良反应.结论 萘替芬酮康唑乳膏联合阿达帕林凝胶治疗花斑糠疹疗效较好,二者联合使用对治疗花斑糠疹有协同治疗作用.

  2. A clinical stttdy to treat pityriasis versicolor with the united treatment of itraconazole and local meidication that repel epiphytes%伊曲康唑和局部抗真菌药物(2%酮康唑洗剂)联合治疗花斑癣的临床效果观察

    Institute of Scientific and Technical Information of China (English)

    伍绍萍; 刘健; 伍绍芬; 刘英华; 邹霞

    2008-01-01

    目的 观察伊曲康唑(美扶)胶囊和局部抗真菌药物(2%酮康唑洗剂)联合治疗花斑癣的临床疗效和复发率.方法 选择358例花斑癣患者,随机分成2组,实验组200例,对照组158例.两组均为皮损处外用药(2%酮康唑洗剂),2~3次/d.每周门诊复查1次.实验组加用口服伊曲康唑胶囊200mg,2次/d,共7d,餐中或餐后立即服用,停药3w为一疗程.记录治疗效果及观察不良反应,连续4W后判定结果 .结果 试验组200例,痊愈182例(91%),显效11例(5.5%),有效6例(3%),复发1例(0.5%),总有效率193例(96.5%);对照组158例,痊愈52例(32.91%),显效23例(14.56%),有效54例(34.18%),无效6例(3.80%),总有效率75例(47.47)%,复发23例(14.55%).两组总有效率、复发率比较,差异均具有极显著性(X2=112.758,P<0.005;X2=27.887,P<0.005).结论 伊曲康唑(美扶)和局部抗真菌药物(2%酮康唑洗剂)联合治疗花斑癣,能提高花斑癣治疗的总有效率,同时降低复发率.

  3. 从花斑癣患者的皮损区及非皮损区分离和鉴定马拉色菌%Isolation and Identification of Malassezia Species from Lesional and Non-lesional Sites of Patients with Pityriasis Versicolor

    Institute of Scientific and Technical Information of China (English)

    李志瑜; 冉玉平; 熊琳; 代亚林; 郭晓莉

    2003-01-01

    目的研究花斑癣患者皮损区及非皮损区马拉色菌菌种构成;不同解剖部位、皮损颜色及各菌种的分布情况;患者病情和年龄与菌种构成的关系.方法用无菌胶带粘取113例花斑癣患者皮损区及非皮损区共629个部位的皮屑,分别接种于含菜子油培养基中分离马拉色菌,用生理生化及形态学方法鉴定菌种.结果皮损区与相对应的非皮损区马拉色菌分离阳性率无差别,非皮损区额部和胸背部分离阳性率高于上、下肢.共分离到565株马拉色菌,鉴定出合轴马拉色菌(44.78%)、糠秕马拉色菌(32.94%)、球形马拉色菌(11.68%)、钝形马拉色菌(5.84%)及限制马拉色菌(4.76%)共5个种,有27处(5 01%)同时分离到两种菌.皮损区与非皮损区菌种构成无明显差别,限制马拉色菌主要从额部分离出.菌种构成与皮损面积无关,但与皮损颜色和患者年龄有关.皮损颜色与病程无关.结论花斑癣患者皮损区与非皮损区马拉色菌分离阳性率和菌种构成基本一致,与病情无关,而不同解剖部位、皮损类型及年龄患者的菌种构成有一定差异.

  4. 花斑癣患者血清中抗糠秕马拉色菌IgG、IgM、IgA抗体的检测及其意义%Detection of antibodies for IgG, IgM and IgA classes against whole Malassezia furfur in sera from patients with pityriasis versicolor and its significance

    Institute of Scientific and Technical Information of China (English)

    王群; 吴勤学; 靳培英

    1999-01-01

    目的:探讨机体体液免疫在花斑癣发病中的作用和意义.方法:以糠秕马拉色菌(M.furfur)整菌(WMF)为抗原,用间接酶联免疫吸附试验(ELISA)方法,检测68例花斑癣患者和41例正常人血清中的抗WMF抗体.结果:正常人血清中存在高滴度的抗WMF抗体,花斑癣患者血清中抗WMFIgG抗体明显低于正常对照组(P<0.01),男性患者血清中IgG抗体低于女性患者(P<0.01),病程1年以上者血清中特异的IgG抗体低于病程不到1年者(P<0.01).结论:机体血清抗M.furfur抗体可能是人体内天然抗体,且特异的IgG抗体具有保护作用.支持花斑癣的发病与免疫缺陷有关.

  5. A case report of confluent and reticulated papillomatosis with acanthosis nigricans:easilly confused with pityriasis versicolor%易与花斑糠疹混淆的融合性网状乳头瘤病合并黑棘皮病1例

    Institute of Scientific and Technical Information of China (English)

    文京华; 李伯埙; 黄小平

    2011-01-01

    融合性网状乳头瘤病为一种少见的原因不明的皮肤病,不易诊断.多见于青少年,好发于躯干部和腋窝,为褐色鳞屑性斑片或斑块.临床易误诊而被延误治疗.报告1例融合性网状乳头瘤病合并黑棘皮病,曾被多次拟诊为"花斑糠疹",有较典型的临床表现和组织病理改变.口服及外用异维A酸治疗有效.%Confluent and reticulate papillomatosis (CRP) with unknown etiology is uncommonly happened and easilly misdiagnosed. CRP occurs predominantly in young adults and teenagers with brown scaling patches and plaques affected the upper trunk and axillae. A case of malignant confluent and reticulated papillomatosis with acanthosis nigricans is reported. The patient had typical clinical manifestations and histopathologic changes. Oral and topical administration of isotretinoin showed therapeutic efficiency.

  6. 消银平Ⅰ号合并胸腺肽肠溶片治疗玫瑰糠疹临床疗效观察%An observation of the clinical therapeutic efficacy of pityriasis rosea patients which were treated by Xiao Yin Ping I in concert with Thymopetidum eneric-coated tablets

    Institute of Scientific and Technical Information of China (English)

    燕陶然; 李凤仙

    2012-01-01

    目的:临床观察消银平l号合并胸腺肽肠溶片治疗玫瑰糠疹临床疗效.方法:我们将115例玫瑰糠疹患者随机分为治疗组和对照组进行观察.治疗组A组42例口服消银平I号及胸腺肽肠容片,治疗组B组38例口服消银平I号,对照组C组35例抗组胺治疗.结果:临床验证A组与B组、C组治愈率比较疗效有显著性差异(P<0.05).A组与C组有效率比较疗效有显著性差异(P<0.05).结论:消银平I号合并胸腺肽肠溶片治疗玫瑰糠疹疗效显著.[关健词]玫瑰糠疹;消银平Ⅰ号;胸腺肽肠溶片;抗组胺药

  7. Evidence-based Danish guidelines for the treatment of Malassezia-related skin diseases

    DEFF Research Database (Denmark)

    Hald, Marianne; Arendrup, Maiken C; Svejgaard, Else L

    2015-01-01

    Internationally approved guidelines for the diagnosis and management of Malassezia-related skin diseases are lacking. Therefore, a panel of experts consisting of dermatologists and a microbiologist under the auspices of the Danish Society of Dermatology undertook a data review and compiled...... guidelines for the diagnostic procedures and management of pityriasis versicolor, seborrhoeic dermatitis and Malassezia folliculitis. Main recommendations in most cases of pityriasis versicolor and seborrhoeic dermatitis include topical treatment which has been shown to be sufficient. As first choice....... Maintenance therapy is often necessary to prevent relapses. In the treatment of Malassezia folliculitis systemic antifungal treatment is probably more effective than topical treatment but a combination may be favourable....

  8. A Clinico - Aetiological Study Of Dermatoses In Paediatric Age Group

    Directory of Open Access Journals (Sweden)

    Ghosh Sadhan K

    1995-01-01

    Full Text Available Five hundred patients of the age group 0-12 years were studied for different types of dermatoses. Pyoderma (35.6%, scabies (22.4% and eczema (17.6% were the most common dermatological conditions, followed by molluscum contagiosum (4.6%, popular urticaria with insect bite (4%, vitiligo (3.4%, miliaria (2.8%, nevus (1.6%. Other dermatoses (8% were pityriasis rosea, wart, chicken pox, herpes zoster, acne vulgaris, leprosy, angular stomatitis, pruritus vulvae, psoriasis, candidiasis, condylomatalata, fixed drug relation, tinea capitis and corporis, phrynoderma, alopecia areata, phimosis, geographic tongue, trichotillomania, canitis, pediculosis, hypertrophic scar and pityriasis versicolor.

  9. Clinicopathological correlation of acquired hypopigmentary disorders

    Directory of Open Access Journals (Sweden)

    Anisha B Patel

    2013-01-01

    Full Text Available Acquired hypopigmentary disorders comprise a significant group of disorders that affect Indians and Asians. The pigment disturbance in darker skin individuals can be very distressing to the patient and the family. These disorders cover a wide array of pathologies including infections, autoimmune processes, lymphoproliferative disorders, and sclerosing diseases. Histological diagnosis is particularly important because treatments for these diseases are varied and specific. This review will focus on histopathological diagnosis based on clinicopathological correlation for commonly encountered disorders such as leprosy, vitiligo, lichen sclerosus, pityriasis alba (PA, and pityriasis versicolor (PV. Atypical or uncommon clinical presentation of classic diseases such as hypopigmented mycosis fungoides (HMF and hypopigmented sarcoidosis are also included.

  10. Prevalence of skin diseases in Varanasi school children

    Directory of Open Access Journals (Sweden)

    Valia A

    1991-01-01

    Full Text Available In a school survey in Varanasi city, 12481 children were examined. More than half (54% had one or more skin diseases. The commonest ones were peduculosis capitis (35%, pityriasis alba (12% acne vulgaris (8%, miliaria (4% and pyodermas (3%

  11. Photosensitivity to selsun shampoo

    Directory of Open Access Journals (Sweden)

    Mani M

    1994-01-01

    Full Text Available A case of photosensitive dermatitis, occurring after the second application of 2.5% selenium sulphide (Selsun shampoo, Abbot, is reported. The shampoo was diluted to half strength with water, before use. The patient had pityriasis versicolor, with extensive lesions on the covered as well as exposed areas.

  12. [Cutaneous Malassezia infections and Malassezia associated dermatoses: An update].

    Science.gov (United States)

    Nenoff, P; Krüger, C; Mayser, P

    2015-06-01

    The lipophilic yeast fungus Malassezia (M.) spp. is the only fungal genus or species which is part of the physiological human microbiome. Today, at least 14 different Malassezia species are known; most of them can only be identified using molecular biological techniques. As a facultative pathogenic microorganism, Malassezia represents the causative agent both of superficial cutaneous infections and of blood stream infections. Pityriasis versicolor is the probably most frequent infection caused by Malassezia. Less common, Malassezia folliculitis occurs. There is only an episodic report on Malassezia-induced onychomycosis. Seborrhoeic dermatitis represents a Malassezia-associated inflammatory dermatosis. In addition, Malassezia allergenes should be considered as the trigger of "Head-Neck"-type atopic dermatitis. Ketoconazole possesses the strongest in vitro activity against Malassezia, and represents the treatment of choice for topical therapy of pityriasis versicolor. Alternatives include other azole antifungals but also the allylamine terbinafine and the hydroxypyridone antifungal agent ciclopirox olamine. "Antiseborrhoeic" agents, e.g. zinc pyrithione, selenium disulfide, and salicylic acid, are also effective in pityriasis versicolor. The drug of choice for oral treatment of pityriasis versicolor is itraconazole; an effective alternative represents fluconazole. Seborrhoeic dermatitis is best treated with topical medication, including topical corticosteroids and antifungal agents like ketoconazole or sertaconazole. Calcineurin inhibitors, e.g. pimecrolimus and tacrolimus, are reliable in seborrhoeic dermatitis, however are used off-label.

  13. Dermatomycoses In Diabetics - A Clinical Study

    Directory of Open Access Journals (Sweden)

    Parthiban K

    1998-01-01

    Full Text Available Two hundred diabetics including 153 non- insulin dependent diabetes mellitus and 47 insulin dependent diabetes mellitus patients, were screened for mycoses. Candidiasis was the commonest mycoses, followed by dermatophtoses and pityriasis versicolor. The fasting blood glucose level was observed to be higher in candidialsis compared to other mycoses.

  14. Childhood hypopigmented mycosis fungoides: a commonly delayed diagnosis.

    Science.gov (United States)

    Gameiro, Ana; Gouveia, Miguel; Tellechea, Óscar; Moreno, Ana

    2014-12-23

    Primary cutaneous lymphomas (PCLs) are exceedingly rare in children and adolescents, with mycosis fungoides (MF) being the most frequent PCL diagnosed in childhood. There are numerous unusual clinical variants of MF, including the hypopigmented type form (HMF). HMF is exceptional overall, but comparatively common among children. We present an 8-year-old boy with a 3-year history of progressive, generalised, scaly, hypopigmented round patches and few erythematous papules. He was first diagnosed with pityriasis alba (PA), and moisturisers were prescribed with no improvement. Skin biopsy showed typical features of MF, and the patient was successfully treated with narrowband ultraviolet B. HMF may simulate atopic dermatitis, PA, pityriasis lichenoides, tinea versicolour, vitiligo, postinflammatory hypopigmentation or leprosy. Therefore, persistent and unusual hypopigmented lesions should be biopsied to rule out this rare variant of MF.

  15. Extent and pattern of paediatric dermatoses in rural areas of central India

    Directory of Open Access Journals (Sweden)

    Bhatia Vikas

    1997-01-01

    Full Text Available A house to house study was done on 666 children aged 0-14 years in 5 villages of Wardha district in Maharastra (Central India. 346 children (51.95% had one or more dermatoses. Infective dermatoses contributed 63.5% of all dermatoses, while noninfectious and nutritional deficiency dermatoses were responsibile for 21.2% and 15.2%, respectively. Pediculosis capitis was seen in 136 children (20.4%, followed by pyoderma in 107 (16.07% and dematophytosis in 44 (6.61%. Scabies was found in only 6 and 4 cases of leprosy were also delected. Pityriasis alba, pityriasis capitis amond non-infectious; hair and skin changes among nutritional deficiency dermatoses were leading presentations.

  16. Clinico-Mycological Study Of Superficial Fungal Infection In Children In An Urban Clinic In Kolkata

    Directory of Open Access Journals (Sweden)

    Barbhuiya Joyashree Nath

    2002-01-01

    Full Text Available Seventy children up to the age of 12 years who were suffering from dermatophytosis, candidiasis or pityriasis versicolor were studied clinically and mycologically. Dermatophytosis was the major group, which constituted 52.86% of children. It was followed by candidiasis that constituted 40% of children and pityriasis versicolor was the least, being 7.14% of children. Amongst the clinical types of dermatophytosis, tinea capitis was the commonest (32.43% followed by tinea corporis (27.03%. Candidial intertrigo was the commonest (42.86% from of candidiasis, followed by diaper dermatitis (32.14%. Most susceptible age group was school going children. Peak incidence of infection was during the months of June to September. T rubrum was the commonest dermatophyte isolated in culture. C. albicans was the most common species of candida isolated in culture.

  17. A Case Report of Changes of Dysplasia and Multiple Malignancies in a Patient with Epidermodysplasia Verruciformis

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    A. Ansar

    2008-04-01

    Full Text Available Introduction: Epidermodysplasia verruciformis(EV is a very rare, chronic and inherited disorder characterized by widespread and persistent HPV infection. EV Patients present with widespread, discrete or confluent lesions that clinically indistinguishable from plane warts , scaly hyper or hypopigmented macules closely resemble pityriasis versicolor, and thicker plaques may resemble seborrbeic keratosis. Susceptibility to the virus is inherited, usually autosomal recessive. The disease usually manifests in childhood and continue throughout the life. The most important complication is cutaneous changes of dysplasia and malignancy.Case Report: We report a 19 years old boy with clinical and histopathological findings compatible with EV and cutaneous changes of dysplasia and malignancy.Conclusion: We concluded that in patients with combination of plane warts, pityriasis versicolor-like lesions and reddish plaques, it may be considered EV, and it is recommended to evaluate cutaneous changes of dysplasia and malignancy.

  18. Disorders of hypopigmentation in children.

    Science.gov (United States)

    Pinto, F J; Bolognia, J L

    1991-08-01

    The most common disorders of hypopigmentation in children are pityriasis alba, vitiligo, nevus depigmentosus, and tinea versicolor. Pityriasis alba usually presents as ill defined, scaly patches of hypomelanosis on the cheeks of children with an atopic diathesis. The face is also a favored site for vitiligo, but the distribution is periorificial, and the pigment loss is complete because of a destruction of melanocytes. Vitiligo is an acquired, progressive disorder in contrast to nevus depigmentosus, which is a stable, congenital leukoderma. The localized form of nevus depigmentosus must be distinguished from an ash leaf spot, the earliest cutaneous manifestation of tuberous sclerosis, whereas the systematized form may be confused with hypomelanosis of Ito, another neurocutaneous disorder. The lesions of tinea versicolor favor the upper trunk of adolescents, and potassium hydroxide examination of the associated scale reveals hyphal and yeast forms of P. orbiculare. Any inflammatory process in the skin such as dermatitis or psoriasis can resolve with areas of hypopigmentation.

  19. [Phototherapy of parapsoriasis].

    Science.gov (United States)

    Westphal, H J; Walther, A

    1989-01-01

    The effectiveness of photo(chemo)therapy was tested on 69 patients with different forms of parapsoriasis (parapsoriasis guttata, n = 14; pityriasis lichenoides et varioliformis acuta, n = 6; and parapsoriasis en plaques, n = 49). The forms of parapsoriasis differed in their response to phototherapy and in their relapse rates. Whereas parapsoriasis guttata can be regarded as a definite indication for UVA therapy, much higher UVA doses are required for pityriasis lichenoides et varioliformis and the probability of relapses is higher. It was not possible to interrupt the relapsing course of parapsoriasis en plaqes in the majority of patients. Relapses occurred within 7 months in 63.2% of the cases. A healing effect that lasted for more than one year was achieved only in 18 patients.

  20. Early Development of Squamous Cell Carsinoma in Two Sister Cases with pidermodysplasia Verruciformis

    Directory of Open Access Journals (Sweden)

    Ömer Çalka

    2010-06-01

    Full Text Available Epidermodysplasia verruciformis (Lewandowsky-Lutz syndrome is an uncommon disease characterized by multiple plane warts, pityriasis versicolor-like lesions, defects of cell-mediated immunity, and tendency to develop skin malignancies, primarily on sun-exposed areas. Most commonly it is inherited as an autosomal recessive trait. Squamous cell carcinoma is the most common type of skin cancer found in patient with epidermodysplasia verruciformis. Human papilloma virus 5, 8, and 47 are found in more than 90% of epidermodysplasia verruciformis skin cancers. Treatment for epidermodysplasia verruciformis consists largely of preventive measures. Photoprotection remains essential for management. In this report, two sister case of epidermodisplasia verruciformis with plane warts, pityriasis versicolor-like lesions, and squamous cell carcinomas on sun-exposed areas of skin was presented for it is a rarely encountered disease and associated with early development of malignancy.

  1. Macrolides in Chronic Inflammatory Skin Disorders

    Directory of Open Access Journals (Sweden)

    Abdullateef A. Alzolibani

    2012-01-01

    Full Text Available Long-term therapy with the macrolide antibiotic erythromycin was shown to alter the clinical course of diffuse panbronchiolitis in the late 1980s. Since that time, macrolides have been found to have a large number of anti-inflammatory properties in addition to being antimicrobials. These observations provided the rationale for many studies performed to assess the usefulness of macrolides in other inflammatory diseases including skin and hair disorders, such as rosacea, psoriasis, pityriasis rosea, alopecia areata, bullous pemphigoid, and pityriasis lichenoides. This paper summarizes a collection of clinical studies and case reports dealing with the potential benefits of macrolides antibiotics in the treatment of selected dermatoses which have primarily been classified as noninfectious and demonstrating their potential for being disease-modifying agents.

  2. Sickle cell anemia in an American white boy of Greek ancestry.

    Science.gov (United States)

    Campbell, J J; Oski, F A

    1977-02-01

    A 7-year-old American white boy of Greek ancestry had sickle cell anemia. The disease in this patient was not accompanied by painful episodes or recognizable hematologic complications, although he did demonstrate considerable delay in skeletal maturation. The patient sought medical attention for a dermatologic problem that was ultimately diagnosed as pityriasis rubra pilaris. To our knowledge, this is the first demonstrated example of sickle cell anemia in a white male described in the United States.

  3. Evaluation eines modifizierten Auxanogramms zur Differenzierung von Malassezia-Hefen mittels ITS1-rDNA-Sequenzierung

    OpenAIRE

    Uhlich, Maren

    2014-01-01

    Malassezia-Hefen sind die Ursache für eine Reihe dermatologischer Erkrankungen wie z.B. der Pityriasis versicolor. Ihre Klassifikation ist in den letzten Jahren immer mehr in den Vordergrund gerückt. Verschiedene phänotypische und molekularbiologische Nachweismethoden wurden zur Differenzierung unterschiedlicher Stämme entwickelt. Anhand dieser Studie wurde die Übereinstimmungsrate der Zuordnungen von Malassezia-Hefen zwischen der etablierten molekularbiologischen Methode nach Makimura et...

  4. Epidermodysplasia verruciformis with Hansen′s disease, herpes simplex labialis and multiple eccrine hidradenoma

    Directory of Open Access Journals (Sweden)

    Padmavathy L

    2009-01-01

    Full Text Available Epidermodysplasia verruciformis (EV - a rare, lifelong heritable disease due to a unique susceptibility to human papilloma virus. The disseminated verrucous lesions or pityriasis versicolor like lesions persist from early childhood and can transform into a cutaneous malignancy in a fourth of patients. The association of EV with multiple eccrine hidradenoma, herpes simplex labialis and Hansen′s disease is a very rare occurrence and is reported in a 25-year-old woman.

  5. Recherche et développement d'extraits antifongiques issus de la flore guadeloupéenne : caractérisations phytochimiques, pharmacologiques et formulation

    OpenAIRE

    Biabiany, Murielle

    2011-01-01

    Despite the existing arsenal of antifungals today, superficial fungal infections have increased over the world and especially in the Caribbean basin. We focused our work on diseases that pose, in Guadeloupe, many problems of resistance or recurence towards current antifungals : dermatophytosis, Pityriasis versicolor (Malassezia sp.), Candidosis and Scytalidiosis. Following this observation, we were interested in the flora of Guadeloupe where ten plants were selected on natural observation, et...

  6. A Case of Confluent and Reticulated Papillomatosis Mimicking Pitriasis versicolor

    Directory of Open Access Journals (Sweden)

    Gürlevik Z et al.

    2012-05-01

    Full Text Available Confluent and reticulated papillomatosis (CRP which is also known as Gourgerot-Corteoud Syndrome is an unusual condition. The etio-pathogenesis is still unclear. This disease is mostly affecting female gender. The most common location for the CRP is on the intermammary and interscapular areas. We presented the case of a male patient with CRP resembling Pityriasis versicolor. The patient was treated with azitromycin and topical retinoid. We observed a good response to azitromycin.

  7. Seasonal variations in dermatologic and dermatopathologic diagnoses: a retrospective 15-year analysis of dermatopathologic data.

    Science.gov (United States)

    Harvell, Jeff D; Selig, Daniel J

    2016-10-01

    Certain dermatologic conditions are known to show seasonal variations in frequency, the reasons for which are unclear but in some cases may be attributable to changes in ambient weather conditions. The current study was conducted to determine whether seasonal trends might exist for dermatologic conditions including erythema multiforme, guttate psoriasis, erythema dyschromicum perstans (ashy dermatosis), pityriasis lichenoides, and pityriasis rosea. Data were derived from a 15-year retrospective review of electronic records from a large dermatopathology laboratory located in the mid-Atlantic region of the USA. Numbers of diagnoses per month and "per season" were determined. Pairwise comparisons of seasonal data were made using two-sample t-tests with significance set at P ≤ 0.05. Perniosis (chilblains) was significantly more common in winter and spring (P = 0.001). Hand, foot, and mouth disease was statistically more prevalent in summer and autumn (P = 0.028). Erythema multiforme was most common in spring and summer (P = 0.004). Grover's disease was most common in winter and spring (P = 0.000039). Guttate psoriasis was non-significantly more common in winter and spring (P = 0.076). No statistically significant seasonal variation was found for erythema dyschromicum perstans (P = 0.899), pityriasis rosea (P = 0.727), or pityriasis lichenoides (P = 0.366). This study found statistically significant seasonal trends for several dermatologic conditions. The study was primarily epidemiologic and was not intended to address histopathologic differences that might underlie the seasonal variations observed. However, further investigation of seasonal differences in the histopathology of erythema multiforme may prove interesting. © 2016 The International Society of Dermatology.

  8. Parapsoriasis lichenoides/parapsoriasis variegata--a new concept.

    Science.gov (United States)

    Wolf, Ingrid H; Kerl, Katrin; Cerroni, Lorenzo; Kerl, Helmut

    2009-11-01

    We present a new concept on the nosology of parapsoriasis lichenoides (= parakeratosis variegata) and show that this parapsoriasis type is not a separate entity. It represents different diseases: a large number of cases presenting as reticular parapsoriasis are mycosis fungoides, another group represents reticular variants of the parapsoriasis guttata group (pityriasis lichenoides acuta et chronica). Further, cases exist that can be classified as lichen planus reticularis or other diseases (e. g. keratosis lichenoides).

  9. 急性痘疮样苔癣性糠疹的中西医研究现状

    Institute of Scientific and Technical Information of China (English)

    宾爱弟; 闫秋红; 陈宏

    2011-01-01

    急性痘疮样苔癣性糠疹(pityriasis lichenoides et varioliformis acuta,PLEVA)又被称为痘疮样型副银屑病.本病易误诊,这里就近十年来对急性痘疮样苔癣性糠疹的中西医研究现状作集中阐述.

  10. The Role of Biopsy in Pediatric Dermatopathology

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    Fatma Şule Afşa

    2011-09-01

    Full Text Available Background and Design: Pediatric dermatology is characterized by skin disorders which have frequencies different from those in adults. Skin biopsies are necessary for differential diagnosis and clinicopathologic correlation is very important. The aim of this study was to evaluate retrospectively the pediatric dermatology cases in whom biopsy was performed for differential diagnosis and to investigate the contribution of biopsy to diagnosis of skin disorders. Material and Methods: The cases from whom biopsy was taken in the pediatric dermatology clinic during a three-year period were evaluated retrospectively for pre-diagnoses, biopsy diagnoses, and success of biopsies.Results: Two hundred thirteen (1.7% skin biopsies had been taken from a total of 12420 patients. Henoch-Schönlein purpura, psoriasis, pityriasis lichenoides, pityriasis rosea, lichen planus, pityriasis rubra pilaris, erythema multiforme, atopic dermatitis, granuloma annulare, and pigmented purpuric dermatosis were the most frequent skin disorders diagnosed dermatopathologically. In a total of 120 (56.3% cases, the biopsy diagnosis was within the pre-diagnosis and a biopsy consistency was present. In 25 (11.7% cases, biopsy had no contribution to the differential diagnosis. An absolutely different diagnosis which was incompatible with the pre-diagnosis had been reported in 10 (4.6% cases. Conclusion: In pediatric dermatology, skin biopsy is very helpful for the differential diagnosis. An easy biopsy procedure for the patient, an effective designation of biopsy indication, a good dermatopathologic correlation and an experienced team of pediatric dermatopathology increase the success of skin biopsies.

  11. Narrowband Ultraviolet B Treatment in Skin Diseases Beyond Vitiligo, Psoriasis and Mycosis Fungoides

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    Dilek Seçkin

    2009-09-01

    Full Text Available Narrowband ultraviolet B, with its nonspecific immunmodulatuar actions, is a potential treatment alternative in many skin diseases. Various studies have shown its effects in psoriasis and vitiligo, treatment protocols have been developed especially for psoriasis. Apart from these, narrowband ultraviolet B is used as first-line therapy in skin conditions that are common in clinical practice. However, its efficacies in such diseases are not very well-known. The effects of narrowband ultraviolet B in atopic dermatitis, pityriasis lichenoides, lichen planus, pruritus, chronic urticaria, symptomatic dermographism and polymorphic light eruption are discussed here in light of the literature data.

  12. Photochemotherapy Less Common Indications for Use

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    Dilek Bayramgürler

    2010-12-01

    Full Text Available Photo(chemotherapy has been used successfully for the treatment of various inflammatory and pigmentary skin disorders mainly including psoriasis, atopic dermatitis, mycosis fungoides, polymorphic light eruption and vitiligo. Beside these, they are used as first-line therapy in skin conditions that are common in clinical practice although their efficacies in such diseases are not very well-known. Here the effects of photo(chemotherapy in alopecia areata, pityriasis lichenoides, lichen planus, chronic urticaria, symptomatic dermographism, uremic pruritus, acquired perforating dermatosis and some others are discussed in light of the literature data.

  13. Characterization of Malassezia Furfur and its control by using plant extracts

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    Vijayakumar R

    2006-01-01

    Full Text Available Malassezia furfur, a lipophilic, dimorphic and yeast-like fungus, occurring in human skin as an opportunistic pathogen, causes diseases such as dandruff, pityriasis versicolar, seborrheic dermatitis, etc. Suitable media for culturing the organism were standardized. A modified medium for the culturing of M. furfur has been proposed. Growth of the fungus was also determined in the presence of different carbon sources under the influence of different temperature, pH and salinity. Plant extracts of 19 species were screened against the growth of the fungus by using disc diffusion method and the results are discussed.

  14. Epidermodysplasia verruciformis: An unusual malignant transformation

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    Prachi G Agrawal

    2013-01-01

    Full Text Available Epidermodysplasia verruciformis (EV is a rare, life-long heritable disease caused due to a unique susceptibility to human papilloma virus. The disseminated verrucous lesions and pityriasis versicolor-like lesions persist from early childhood and can transform into a cutaneous malignancy in a fourth of patients. Malignant transformation into syringoid eccrine carcinoma (SEC has been reported only once so far. SEC is an extremely invasive, rare, locally destructive, slowly growing adnexal tumor. We hereby report the association of EV with SEC in a 29-year-old male.

  15. Parapsoriasis and related conditions.

    Science.gov (United States)

    Piamphongsant, T

    1988-10-01

    Classification of parapsoriases is revised into a simple practical table. Pityriasis lichenoides (guttate parapsoriasis) is not a type of parapsoriasis. The clinical features of small patch and large plaque parapsoriasis are described in detail. Six clinical varieties of large plaque parapsoriasis and three clinical varieties of exfoliative dermatitis including Sézary syndrome have been clearly recognized as distinctive categories. Histopathology is useful for the diagnosis of parapsoriasis and mycosis fungoides. Sézary cell count is not significant for the diagnosis of Sézary syndrome.

  16. Cutaneous fungal infection in a renal transplantation patient due to a rare fungus belonging to order Pleosporales

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    S Galipothu

    2015-01-01

    Full Text Available Fungal infections are being increasingly reported from immuno-compromised as well as immuno-competent patients. Transplant patients are on long term immunosuppressive therapy which makes them highly vulnerable to opportunistic fungal infections .These infections can be cutaneous or systemic. Several fungi have been reported to be the culprits such as Candida spp., Aspergillus spp., C. neoformans, P. carinii, and zygomycetes group of fungi. Cutaneous infections are most commonly caused by Pityriasis (tinea versicolor, dermatophytes, and candida sp but these days the demtiaceous fungi are becoming more frequently reported .Here we report a case of post renal transplant cutaneous infection caused by dematiaceous fungus belonging to the order Pleosporales

  17. Interface dermatitis

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    Rajiv Joshi

    2013-01-01

    Full Text Available Interface dermatitis includes diseases in which the primary pathology involves the dermo-epidermal junction. The salient histological findings include basal cell vacuolization, apoptotic keratinocytes (colloid or Civatte bodies, and obscuring of the dermo-epidermal junction by inflammatory cells. Secondary changes of the epidermis and papillary dermis along with type, distribution and density of inflammatory cells are used for the differential diagnoses of the various diseases that exhibit interface changes. Lupus erythematosus, dermatomyositis, lichen planus, graft versus host disease, erythema multiforme, fixed drug eruptions, lichen striatus, and pityriasis lichenoides are considered major interface diseases. Several other diseases (inflammatory, infective, and neoplastic may show interface changes.

  18. The first case of isolation of malassezia globosa in our country

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    Arsić-Arsenijević Valentina S.

    2003-01-01

    Full Text Available Today is known that genus Malassezia includes seven species: M. furfur, M. sympodialis, M. obtusa, M. globosa, M. restricta, M. slooffiae and M. pachydermatis, but role of each of the species in the pathogenesis of desease has not been eluciated yet, so futher laboratory isolation and identification are necessary. We report the first case of isolation of Malassezia globosa in Serbia (Belgrade, in a patient suffering from Pityriasis versicolor. Identification of M. globosa was based on macroscopic, microscopic and biochemical characteristics. Isolation was done on Leeming and Notman medium and on mDixona agar, at 350C, during 7 days in aerobic conditions. Also the yeast's biochemical phenotype was determined as catalase (+, lipase (+, esculin degradation (-, Tween (20,40, 60 and 80 asimilation (-. M. globosa is a lipophilic yeast of the genus Malassezia and the common member of the skin flora. In concordance with some predis-poning factors M. globosa is implicated in the pathogenesis of several skin diseases (pityriasis versicolor, malassezia foliculitis sebor-rheic dermatitis and some forms of atopic dermatitis. In immuno-compromised patients and neonates this yeast can even cause fatal systemic infections. Because the role of Malassezia spp. in pathogenesis of skin desease is not still determined, we suggest laboratory diagnosis and identification of these species as a routine diagnostic procedure.

  19. Epidermodisplasia verruciforme: apresentação clínica com variadas formas de lesões Epidermodysplasia verruciformis: clinical presentation with varied forms of lesions

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    Naiana Bittencourt de Sá

    2011-08-01

    Full Text Available Epidermodisplasia verruciforme é uma genodermatose rara caracterizada por infecção disseminada por HPV, de caráter recessivo, com casos ligados ao cromossoma X. É caracterizada clinicamente por lesões maculares hipo ou hiperpigmentadas, lesões pitiríase versicolor like, verrugas planas e desenvolvimento precoce de carcinomas cutâneos. Descreve-se um caso de paciente com quadro clínico exuberante, apresentando todas as formas de lesões desta doença, inclusive presença de carcinoma espinocelular agressivo na faceEpidermodysplasia verruciformis is a rare inherited skin disorder spread by HPV, with cases linked to chromosome X. It is characterized by hypo- or hyper-pigmented macular lesions, pityriasis versicolor-like lesions and an early tendency to develop skin malignancies. We present a case of epidermodysplasia verruciformis with a variety of lesions such as multiple plane warts, pityriasis versicolor-like lesions and aggressive squamous cell carcinoma on the face

  20. The morphology of keratohyalin granules in orthokeratotic and parakeratotic skin and oral mucosa.

    Science.gov (United States)

    Westerhof, W; Dingemans, K P

    1987-06-01

    We compared morphologic features of keratohyalin granules (KHG) that were directly related to keratinization in oral mucosa (tongue, cheek, gums, palate; n = 4) with those in parakeratotic epidermis (psoriasis, n = 2; pityriasis rubra pilaris, n = 1; acute dermatitis, n = 1) and normal orthokeratotic epidermis. Among others, the ultrastructural features of globular KHG were observed in the cheek, nonspecialized tongue mucosa, and parakeratotic epidermis occurring in psoriasis, pityriasis rubra pilaris, and acute dermatitis, whereas gums and palate showed a mixture of characteristics, also resembling stellate KHG as seen in normal skin. From literature as well as from our studies, the impression was gained that globular KHG were found especially in quickly dividing epithelia and could easily be distinguished from the irregular or stellate KHG that were found in slowly dividing normal epidermis. Therefore, we studied keratinization features on days 3, 7, and 14 after autografting normal human skin (n = 4), thus inducing high cell turnover. Stellate KHG, present in granular cells of normal skin, were almost absent on the third day. Active cell division on the seventh day resulted in sparse keratohyalin formation inside globular granules of low electron density, whereas numerous, rather electron-translucent lipid droplets occurred in upper spinous and horny cells. These two phenomena seemed to be interrelated. After 14 days, round and increasingly electron-dense KHG were noted.(ABSTRACT TRUNCATED AT 250 WORDS)

  1. Dermatomycosis among Elementary School Children in Jatinangor West Java

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    Isni Maulina Sukmara

    2015-06-01

    Full Text Available Background: Dermatomycosis often occurs in tropical countries. Many studies from tropical countries have reported high prevalence of dermatomycosis among elementary school children. Despite being a tropical country, prevalence of dermatomycosis among elementary school children in Indonesia is still unknown. The objective of this study was to determine the prevalence and characteristics of dermatomycosis among elementary school children in Jatinangor, Sumedang, West Java in September–November 2012. Methods: This study used a cross-sectional descriptive survey method. The 328 children from five elementary schools in Jatinangor were included in the study using multistage sampling technique. Medical history and physical examination was performed to all subjects. Subjects who had skin lesion suspected for dermatomycosis were examined with direct microscopic examination using 10% solutions of potassium hydroxide (KOH. Data were presented as frequent analysis distribution using Statistical Package for Social Sciences (SPSS version 17.0. Results: Of 328 children (174 males, 154 females; aged 5–14 years, 35 (10.6% had lesions suggestive of dermatomycosis but only 5 children (1.5% were positive for dermatomycosis. Males are more prevalent females, patients were in ≥10 years age group. Four cases were Pityriasis versicolor, while one was diagnosed with tinea facialis. Conclusions: Dermatomycosis among elementary school children in Jatinangor had a low prevalence, with only 4 cases of Pityriasis versicolor and one tinea facialis case.

  2. Histopathological spectrum of Psoriasiform dermatitis

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    PL Jayalakshmy

    2016-09-01

    Full Text Available Background: Psoriasiform dermatitis is a frequently encountered terminology in a wide variety of inflammatory dermatoses. It often poses challenges to both dermatologists and pathologists alike. Clinical features when considered alone may not be reliable, as they vary with both disease duration and treatment. On the contrary, histopathological material constitutes definite hard evidence, which can be preserved and will continue to be available for future review. The objective of the study is to study the histopathological findings in Psoriasiform dermatitis.Materials and Methods: This is a retrospective study in a tertiary care centre in Kerala, South India. All cases diagnosed as Psoriasis or mentioned as one of the differential diagnosis were included. The material included 66 skin biopsies. Patients with a previous diagnosis of the same were excluded from the study.Results: The lesions comprised 9% of the total number of skin biopsies. The age distribution pattern revealed that the highest percentage was in the 41-60 year age group (50% with a male preponderance of 65%. Psoriasis was the most common lesion (60.60% and Lichen simplex chronicus was the second most common lesion (10.60 %, encountered in the study.Conclusion: Some of the histopathological features are specific and characteristic for each entity like Psoriasis, Pityriasis rubra pilaris, Pityriasis rosea and Inflammatory linear verrucous epidermal nevus whereas some overlap in lesions like Prurigo nodularis, Lichen simplex chronicus and Allergic contact dermatitis. Hence, combination of proper clinical observation and histopathological study will give a conclusive diagnosis.

  3. Health education and active search for cases of leprosy in a public school in Ananindeua, Pará, Brazil

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    Bruna Ranyelle Marinho Sousa

    2013-04-01

    Full Text Available Objectives: To describe action for leprosy control through health education and case active search among school age children in a public school in the municipality of Ananindeua, Pará state. Methods: This is a descriptive study conducted in a public school including elementary school students. In October and November 2010, lectures on leprosy and other skin lesions were given in this school and then screening was performed with students that presented skin spots. From the total of 532 students involved, 55 were identified as suspected to leprosy. These students were taken to dermatological appointment including clinical examination and application of socio-demographic questionnaire. Results: The face (49% and upper limbs (45% were the main body areas presenting lesions. In most of the cases investigated, pityriasis alba (42% and pityriasis versicolor (31% were diagnosed. However, one case of leprosy (2% was also found, in tuberculoid clinical form. Conclusion: Considering the scope of the study, the number of leprosy cases found is significant and confirms the high detection rate of leprosy in children under age 15 in the city. Epidemiological surveillance actions should be intensified in order to detect the disease in its early stage, contributing to enhancement in social participation by reducing the disease-related stigma.

  4. Antifungal activities of fluconazole and ketoconazole agentsagainst Malassezia species

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    Mehdi Nazeri1

    2009-01-01

    Full Text Available (Received 12 Oct, 2008; Accepted 20 Apr, 2009AbstractBackground and purpose: Malassezia, a yeast-like fungus found in normal skin flora is known to be associated with various skin diseases, along with systemic infections. Our aim was to determine the in -vitro susceptibility of Malassezia spp. to ketoconazole and fluconazole.Materials and methods: In this study, we identified 99 Malassezia isolates from patients with pityriasis vesicular by morphological and biochemical criteria. In vitro susceptibility testing was in macro-broth dilutions, conducted based on the National Committee for Clinical Laboratory Standards (NCCLS M27-A proposed standard. The results were analyzed statistically by Mann-Whitney.Results: The Malassezia isolates were identified as M. globosa (42, M. furfur (39, M. obtusa (10, M. sympodialis (6, and M.slooffiae (2. The rate of MFC of ketoconazole against Malassezia spp. was 0.06-2 µg/ml, while the MFC of fluconazole against Malassezia spp. was 2-64 µg/ml. The minimal inhibitory concentration (MIC90 of ketoconazole against Malassezia spp. was 0.03-1 µg/ml, while the minimal inhibitory concentration (MIC90 of fluconazole against Malassezia spp. was 0.5-32 µg/ml.Conclusion: Although fluconazole can be an effective treatment option for pityriasis versicolor, in our study, fluconazole MICs were higher than ketoclonazole. J Mazand Univ Med Sci 2009; 19(69: 22-27 (Persian

  5. Clinical and epidemiological features of the genus Malassezia in Iran.

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    Elham Zeinali

    2014-10-01

    Full Text Available The genus Malassezia contains an expanding list of lipophilic yeasts involve in the etiology of various superficial fungal infections. Pityriasis versicolor (PV is the most prevalent Malassezia-related infection distributed worldwide. In the present study, clinical and epidemiological features of the genus Malassezia are discussed with special focus on PV in Iran.During June 2012 to April 2013, among 713 confirmed cases of fungal infections, 68 (9.5% were diagnosed as PV by positive direct microscopy results in 20% potassium hydroxide (KOH preparation of skin scrapings. All the specimens were cultured on modified Dixon agar and incubated at 32°C for 10 days. Identification of the isolated yeasts was carried out based on macro- and microscopic morphology, catalase test, utilization of Tweens, polyethoxylated castor oil (EL slant, and hydrolysis of esculin and utilization of Tween-60 (TE slant.Out of 68 skin scrapings, 55 (80.9% yielded yeast colonies on mDixon's agar which were finally identified as M. globosa (36.36%, M. pachydermatis (29.08%, M. furfur (23.65%, M. slooffiae (7.28% and M. obtusa (3.64%.Results of the present study further indicate clinico-epidemiological importance of the genus Malassezia with growing importance of M. pachydermatis as a major species involve in the etiology of pityriasis versicolor. These findings are of major concern in management of Malassezia-related diseases.

  6. The tryptophan aminotransferase Tam1 catalyses the single biosynthetic step for tryptophan-dependent pigment synthesis in Ustilago maydis.

    Science.gov (United States)

    Zuther, Katja; Mayser, Peter; Hettwer, Ursula; Wu, Wenying; Spiteller, Peter; Kindler, Bernhard L J; Karlovsky, Petr; Basse, Christoph W; Schirawski, Jan

    2008-04-01

    Tryptophan is a precursor for many biologically active secondary metabolites. We have investigated the origin of indole pigments first described in the pityriasis versicolor-associated fungus Malassezia furfur. Some of the identified indole pigments have properties potentially explaining characteristics of the disease. As M. furfur is not amenable to genetic manipulation, we used Ustilago maydis to investigate the pathway leading to pigment production from tryptophan. We show by high-performance liquid chromatography, mass spectrometry and nuclear magnetic resonance analysis that the compounds produced by U. maydis include those putatively involved in the etiology of pityriasis versicolor. Using a reverse genetics approach, we demonstrate that the tryptophan aminotransferase Tam1 catalyses pigment biosynthesis by conversion of tryptophan into indolepyruvate. A forward genetics approach led to the identification of mutants incapable of producing the pigments. These mutants were affected in the sir1 gene, presumably encoding a sulphite reductase. In vitro experiments with purified Tam1 showed that 2-oxo 4-methylthio butanoate serves as a substrate linking tryptophan deamination to sulphur metabolism. We provide the first direct evidence that these indole pigments form spontaneously from indolepyruvate and tryptophan without any enzymatic activity. This suggests that compounds with a proposed function in M. furfur-associated disease consist of indolepyruvate-derived spontaneously generated metabolic by-products.

  7. The utility of the in situ detection of T-cell receptor Beta rearrangements in cutaneous T-cell-dominant infiltrates.

    Science.gov (United States)

    Magro, Cynthia M; Nuovo, Gerard J; Crowson, A Neil

    2003-09-01

    The diagnostic assessment of cutaneous T-cell infiltrates is problematic for dermatopathologists. A variety of conditions, including lymphomatoid hypersensitivity reactions and lymphomatoid lupus erythematosus, can demonstrate lymphoid atypia and phenotypic changes that can mimic cutaneous T-cell lymphoma (CTCL). A similar issue revolves around lymphoid dyscrasias, which includes parapsoriasis, atypical pigmentary purpura, pityriasis lichenoides chronica, indeterminate lymphocytic lobular panniculitis, and lymphomatoid papulosis, which can progress to CTCL. A reverse transcription (RT) in situ PCR assay for T-cell receptor beta rearrangements (TCRbeta) was used to assess T-cell clonality in formalin-fixed, paraffin-embedded tissues. In 7 of 8 cases of classic CTCL, the RT in situ PCR assay for TCRbeta rearrangement showed monoclonality; the other was biclonal. Further, in cases with multiple lesions over time, the same T-cell clone could be detected including in those patients whose biopsies showed large-cell transformation. Monoclonality was also demonstrated in each of 2 cases of cutaneous lymphomatoid papulosis. Demonstration of oligoclonality (and one case of biclonality) by RT in situ PCR was confined to those cases that either represented prelymphomatous conditions such as large plaque parapsoriasis or pityriasis lichenoides or lesions of drug-induced lymphomatoid hypersensitivity that all demonstrated clinical regression. In conclusion, RT in situ PCR for TCRbeta, which can be done on formalin-fixed biopsies and allows direct correlation of the molecular data with the histology, is a useful adjunctive test in the differentiation of CTCL from its mimics.

  8. PATTERN OF CUTANEOUS DISEASES IN INMATES OF CENTRAL JAIL, LUDHIANA, PUNJAB

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    Bimal

    2014-04-01

    Full Text Available BACKGROUND: Prisons are fertile breeding places for many skin infections and infestations; also the prevalent stressful conditions may aggravate preexisting skin problems. OBJECTIVES: To determine the pattern of cutaneous diseases in Central Jail, Ludhiana, Punjab (male prison. MATERIALS AND METHODS: The jail inmates were examined as a part of special skin camp organized in the Central Jail Ludhiana by the dermatologist after eliciting a brief history. RESULTS: Of the 157 patients examined, 70% were infectious; commonest being scabies followed by pyodermas, dermatophytosis, pityriasis versicolor, warts. Eczemas and Acne vulgaris were the most common non-infectious conditions seen. CONCLUSIONS: We recommend screening of new inmates by a dermatologist and periodic skin camps to be conducted in prisons at regular intervals.

  9. Leprosy in the Bible.

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    Grzybowski, Andrzej; Nita, Małgorzata

    2016-01-01

    For many years, the biblical term tzaraat has referred to leprosy. In fact, the disease or diseases described under this name have no relationship to leprosy, as it was known in the Middle Ages or today; moreover, the term referred not only to skin disease, but also to the state of the ritual impurity and punishment for the sins. Although the real nature of tzaraat remains unknown, the differential diagnosis might include the following: Psoriasis, seborrheic dermatitis, favus, dermatophyte infections, nummular dermatitis, atopic dermatitis, pityriasis rosea, crusted scabies, syphilis, impetigo, sycosis barbae, alopecia areata, furuncles, scabies, neurodermatitis, scarlet fever, lupus erythematosus, lichen sclerosus et atrophicus, folliculitis decalvans, morphea, sarcoidosis, and lichen planopilaris. Leprosy became interchangeable with the biblical leprosy due to two inaccurate translations: The Hebrew tzaraat was first translated into Greek as leprosy in the sixth century, and later, the word leprosy was translated into Arabic as lepra in the ninth century.

  10. Non-acne dermatologic indications for systemic isotretinoin.

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    Akyol, Melih; Ozçelik, Sedat

    2005-01-01

    Systemic isotretinoin has been used to treat severe acne vulgaris for 20 years. However, isotretinoin also represents a potentially useful choice of drugs in many dermatologic diseases other than acne vulgaris. Diseases such as psoriasis, pityriasis rubra pilaris, condylomata acuminata, skin cancers, rosacea, hidradenitis suppurativa, granuloma annulare, lupus erythematosus and lichen planus have been shown to respond to the immunomodulatory, anti-inflammatory and antitumor activities of the drug. Isotretinoin also helps prevent skin cancers such as basal cell carcinoma or squamous cell carcinoma. A combination of systemic isotretinoin and interferon-alpha-2a may provide a more potent effect than isotretinoin alone in the prevention and treatment of skin cancers.Systemic isotretinoin may be considered as an alternative drug in some dermatologic diseases unresponsive to conventional treatment modalities. However, randomized clinical trials aimed at determining the role of systemic isotretinoin therapy in dermatologic diseases other than acne vulgaris are required.

  11. Management of Cosmetic Embarrassment Caused by Malassezia spp. with Fruticose Lichen Cladia Using Phylogenetic Approach

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    Anand Pandey

    2013-01-01

    Full Text Available During anti-Malassezia screening of plants by CLSI broth microdilution method, Cladia aggregata (Swartz Nyl. (family Cladoniaceae, a fruticose lichen from Sikkim (northeast Himalayan region, has been found effective at minimum inhibitory concentrations (mg/mL of 2.72, 0.63, and 1.28 against yeast-like fungi namely, M. furfur, M. globosa and M. sympodialis, respectively. These test pathogens are responsible for pityriasis versicolor (PV and seborrheic dermatitis (SD in humans. We tried to establish the reason for variable MICs against various Malassezia spp. using bioinformatical tools, thereby reducing the cost of the experimentation. This is the first report on anti-Malassezia activity of C. aggregata and thus can serve as a potential source for the development of cosmaceuticals.

  12. Identification of Malassezia species.

    Science.gov (United States)

    Kindo, A J; Sophia, S K C; Kalyani, J; Anandan, S

    2004-01-01

    Malassezia spp. are lipophilic unipolar yeasts recognized as commensals of skin that may be pathogenic under certain conditions. The genus Malassezia now comprises of seven species. This study was aimed at using a simple practical approach to speciate Malassezia yeasts from clinical material. Seventy skin scrapings from patients with pityriasis versicolor infection, positive in 10% potassium hydroxide (KOH), were cultured onto modified Dixon's agar (mDixon's agar) and Sabouraud dextrose agar (SDA) and incubated at 32 degrees C. Speciation was done on the basis of Gram stain morphology, catalase test, and utilization of Tweens. Out of 70 scrapings 48 (68.75%) showed growth on mDixon's agar. The commonest isolate was M. sympodialis (28, 58%) followed by M. globosa (19, 40%) and one isolate was (2%) of M. restricta. M. sympodialis was the commonest species affecting our population and there was no isolation of M. obtusa, M. slooffiae, M. pachydermatis and M. furfur.

  13. CUTANEOUS MANIFESTATIONS ASSOCIATED WITH DIABETES MELLITUS

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    Satish

    2014-09-01

    Full Text Available Diabetes mellitus (DM refers to a group of common metabolic disorders that share the phenotype of hyperglycemia. The metabolic dysregulation associated with DM causes secondary pathophysiologic changes in multiple organ systems that impose a tremendous burden on the individual with diabetes and on the health care system. AIM: of the study was to evaluate presence and prevalence of common dermatoses in patients. 250 cases of D.M. with various cutaneous manifestations attending in and outpatient department of Dr. D. Y. Patil medical hospital were evaluated. Detailed history was taken as per proforma and patient investigated. Maximum incidence was seen between 40-70 yrs. of age and in middle class. Fungal infection constituted highest number which included dermatophytosis, candidiasis and pityriasis versicolor. No cutaneous reactions to therapy for diabetes were encountered in the present study.

  14. Genetic illnesses of the skin

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    Yordania Velázquez Avila

    2015-09-01

    Full Text Available At present, many genetic diseases, from 85 to 90 %, are considered rare diseases, since they affect a small number of individuals. The poor knowledge about them makes it difficult to diagnose them; they are chronic, incapacitating, with few therapeutic options diseases and often makes the patients’ adequate social integration impossible. The genodermatosis are part of the group of rare, uncommon and difficult to diagnose skin diseases; they are a frequent cause of stigmatization of those people who suffer from them. They may include: ichthyosis, epidermolysis bullosa, mastocytosis, neurofibromatosis, ectodermal dysplasia, palmoplantar keratoderma, Ehlers-Danlos syndrome, incontinentia pigmenti, pityriasis rubra pylaris, xeroderma pigmentosum, epiloia, Darier's disease, and vascular tumors, among others. It is necessary to increase knowledge about them in the field of medical sciences, allowing a better treatment for patients and improve their quality of life, as well as contribute to their prevention.

  15. Alternative uses of dermoscopy in general dermatology

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    Eleni Papakonstantinou

    2017-02-01

    Full Text Available Over the last few years, dermoscopy has been shown to be an effective diagnostic tool in assisting the noninvasive diagnosis not only of skin tumors but also of various general dermatological disorders. The use of dermoscopy has offered a new morphological dimension supporting the diagnosis and clinical follow-up of several dermatological conditions. Within the last years, dermoscopy is gaining ground in general dermatology as well. Among the large spectrum of skin infections, specific dermoscopic patterns have been described for common skin infections such as viral warts, molluscum contagiosum, scabies, and pediculosis, as well as for tinea nigra, tungiasis, and cutaneous larva migrans. Also, common skin disorders such as psoriasis, pityriasis rosea or lichen planus show characteristic dermoscopic patterns. The aim of this article is to provide an overview of the use of dermoscopy in general dermatology by analyzing the dermoscopic differential diagnosis of relatively common dermatological   disorders grouped according to their clinical characteristics.

  16. Cutaneous hypopigmentary disorders – An observational study

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    Kalegowda Deepadarshan

    2016-04-01

    Full Text Available Background: Hypopigmented skin lesions is very common among people of all age groups. There are limited studies in India about evaluation of hypopigmented skin conditions. The aim of my study is to evaluate the different etiologies of cutaneous hypopigmentation. Aim: The present study was undertaken to find the relative incidence of the various disorders causing a hypopigmented lesion in a random sample of 200 cases and to study site, distribution and characteristics of the lesions. Methods: A random sample of 200 patients presenting with one or more hypopigmented lesions to the outpatient department of Dermatology, Venereology and Leprosy in KVG Medical College and Hospital, Sullia from December 2011 to January 2013 was studied. Detailed history including address and occupation with special reference to onset and duration, preceding skin conditions, exposure to chemicals, topical application and family history was taken. Various characteristics of the lesion like site, size, number, distribution, surface and sensation were studied. After this samples were taken for relevant investigations like complete hemogram, biopsy, slit skin smear, KOH mount and assessed for the causes of hypopigmented lesions. Results: In our study, most common cause with cutaneous hypopigmentation was pityriasis versicolor, seen in 52%, followed by post inflammatory hypopigmentation in 32%, pre vitiligo in 6.5%, Hansen’s disease, idiopathic guttate hypomelanosis, nevus anemicus each in 2%, Woronoff’s ring in 1.5% and miscellaneous conditions in 2% of the cases. Commonest age group affected was 21-30 years. Males (49% and females (51% were almost equally affected. Conclusion: The study concludes that various conditions comes under hypopigmentary disorders. More common in young adults. Most common scaly condition was pityriasis versicolor and non scaly condition was pre vitiligo. Proper counseling and ruling out Hansen’s disease is required to alleviate the patient

  17. (Industrial dermatoses among the Belthatow brown coal miners)

    Energy Technology Data Exchange (ETDEWEB)

    Ruszczak, Z.; Bienias, L.; Proszyncka-Kuczynska, W.

    1981-01-01

    443 subjects were examined, 235 applying to the physician due to the occurrence of skin dermatoses (group I) and 208 workers referred for periodic examinations (group II). In group I skin dermatoses were found in 100, i.e. 85%, of the subjects and in group II in 99 i.e. 48% of the subjects. In both groups the most frequent dermatosis was feet skin inflammation, especially interdigital intertrigo. Oil acne was diagnosed in 15, ordinary acne in 23, pityriasis versicolor in 19. erythrasma in 10, and eczema and contact dermatitis in 7 subjects of the first group and 3 subjects of the other group. 204 subjects with feet skin pathologies underwent mycologic examinations and 36 subjects--also bacteriologic examinations. The results of those studies indicate that in 23% of the subjects, feet interdigital intertrigo results from mycologic infections. Bacterial infections may contribute to etiopathogenesis. Imidazole compounds are useful for the treatment and prevention of interdigital intertrigo.

  18. Susceptibility pattern of Malassezia species to selected plant extracts and antifungal agents

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    G Sibi

    2014-01-01

    Full Text Available Objective: Malassezia is associated with dandruff, seborrhoeic dermatitis, pityriasis versicolor folliculitis and atopic eczema. This study determined the susceptibility pattern of Malassezia furfur, M. globosa, M. obtusa, M. restricta, M. slooffiae and M. sympodialis isolated from patients diagnosed with dandruff against plant extracts and antifungal agents. Materials and Methods: Twenty aqueous plant extracts and five azole drugs were tested against the isolates by well diffusion and broth dilution method. Results: Among the plant extracts, Phyllanthus emblica (fruits, Hibiscus rosa sinensis (flowers and Acacia concinna (pods have demonstrated significant antidandruff activity. Minimum inhibitory concentration values revealed that ketoconazole as the most effective drug followed by itraconazole. Conclusion: M. furfur and M. globosa were found as the most susceptible organisms against the aqueous extracts of Phyllanthus emblica (fruits, Hibiscus rosa sinensis (flowers, Acacia concinna (pods and azole drugs.

  19. Ensaio terapêutico com o Ketoconazol na pitiríase versicolorTherapeutic trial with Ketoconazole in PV

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    Leila Dagher

    1982-11-01

    Full Text Available Experimentação terapêutico-laboratorial com o Ketoconazol na Pitiríase Versicolor, obtendo os seguintes resultados: - Curados, 16 (88,88% pacientes; Melhorados, 2 pacientes (11,11%, Inalterados e Piorados, nenhum caso (0,00%, no total de 18 doentes estudados. Do ponto de vista laboratorial, houve negativação dos exames micológicos em 100,00% dos casos.Eighteen patients with pityriasis versicolor were treated with a single daily dose of 200mg of Ketoconazole administered with a meal, for a period of 30 days. Evaluation was based on clinical and mycological responses. Clinical and parasitoligical cure was obtained in 16 (88,88% patients and marked clinical improvement in 2(11,11%. No undesirable side effects were observed in the treatment.

  20. Radiation therapy of psoriasis and parapsoriasis

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    Wiskemann, A.

    1982-09-15

    Selective UV-Phototherapy with lambda 300-320 nm (SUP) as well as oral photochemotherapy with 8-methoxy-psoralen plus UVA-radiation (PUVA intern) are very effective in clearing the lesions of the generalized psoriasis and those of the chronic forms of parapsoriasis. Being treated with 4 suberythemal doses per week psoriasis patients are free or nearly free of symptoms after averagely 6.3 weeks of SUP-therapy or after 5.3 weeks of PUVA orally. The PUVA-therapy is mainly indicated in pustular, inverse and erythrodermic psoriasis as well as in parapsoriasis en plaques and variegata. In all other forms of psoriasis and in pityriasis lichenoides-chronica, we prefer the SUP-therapy because of less acute or chronic side effects, and because of its better practicability. X-rays are indicated in psoriais of nails, grenz-rays in superficial psoriatic lesions of the face, the armpits, the genitals and the anal region.

  1. Clinical evaluation of clotrimazole. A broad-spectrum antifungal agent.

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    Spiekermann, P H; Young, M D

    1976-03-01

    The efficacy and safety of the broad-spectrum, topically applied antifungal agent clotrimazole were evaluated in two double-blind, multicentric trials. Ten investigators reported on a total of 1,361 cases in which a 1% solution or a 1% cream formulation was compared with its respective vehicle. Clotrimazole was therapeutically effective, as confirmed by mycological cure (negative microscopy and culture) and clinical improvement, in tinea pedis, tinea cruris, tinea corporis, pityriasis versicolor, and cutaneous candidasis. Furthermore, species identification established the efficacy of clotrimazole against Trichophyton rubrum, T mentagrophytes, Epidermophyton floccosum, Microsporum canis, Malassezia furfur (Pityrosporum orbiculare), and Candida albicans. Safety was demonstrated by the low incidence of possibly drug-related adverse experiences, namely, 19 (2.7%) of 699 patients who were treated with clotrimazole, of whom four (0.6%) discontinued treatment.

  2. Anti-inflammatory and immunomodulatory effects of macrolide antibiotics and their use in dermatology%大环内酯类抗生素的抗炎与免疫调节作用在皮肤科的应用

    Institute of Scientific and Technical Information of China (English)

    张芳; 张锡宝

    2014-01-01

    大环内酯类抗生素除抗菌作用外,还兼有抗炎和免疫调节作用,主要通过抑制中性粒细胞趋化、迁移,促进免疫细胞凋亡,减少炎症介质释放,下调黏附分子表达及影响细胞信号转导通路等交织作用共同发挥抗炎和免疫调节活性.在皮肤科应用方面,除用于感染性皮肤病外,对某些炎症性或免疫性皮肤病,如银屑病、玫瑰糠疹、痤疮、酒渣鼻、苔藓样糠疹、融合性网状乳头瘤病、色素性痒疹、家族性慢性良性天疱疮、大疱性类天疱疮等亦有较好的疗效.%Apart from antimicrobial effects,macrolide antibiotics also have anti-inflammatory and immunomodulatory effects via inhibiting the chemotaxis and migration of neutrophils,accelerating the apoptosis of immune cells,attenuating the secretion of inflammatory mediators,down-regulating the expression of adhesion molecules and affecting cellular signal transduction pathways.In dermatology,macrolide antibiotics not only are used to treat infectious dermatoses,but also show favorable therapeutic effects on some inflammatory or immune dermatoses such as psoriasis,pityriasis rosea,acne,rosacea,pityriasis lichenoides,confluent and reticulated papillomatosis,prurigo pigmentosa,Hailey-Hailey disease,bullous pemphigoid,etc.

  3. A clinico-etiological study of dermatoses in pediatric age group in tertiary health care center in South Gujarat region

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    Sugat A Jawade

    2015-01-01

    Full Text Available Background: Dermatologic conditions have different presentation and management in pediatric age group from that in adult; this to be studied separately for statistical and population based analysis. Objective: To study the pattern of various dermatoses in infants and children in tertiary health care center in South Gujarat region. Materials and Methods: This is a prospective study; various dermatoses were studied in pediatric patients up to 14 years of age attending the Dermatology OPD of New Civil Hospital, Surat, Gujarat over a period of 12 months from June 2009 to June 2010. All patients were divided into four different study groups: 1 to 6 years and 7 to 14 years. Results: There were 596 boys and 425 girls in total 1021 study populations. Majority of the skin conditions in neonates were erythema toxicum neonatorum (12.97%, scabies (9.92%, mongolian spot (9.16%, and seborrheic dermatitis (7.63%. In > 1 month to 14 years age group of children among infectious disorder, children were found to be affected most by scabies (24.49%, impetigo (5.96%, pyoderma (5.62%, molluscum contagiosum (5.39%, tinea capitis (4.49%, leprosy (2.02%, and viral warts (1.35% while among non-infectious disorders, they were affected by atopic dermatitis (4.27%, pityriasis alba (4.16%, seborrheic dermatitis (3.60%, pityriasis rosea (3.15%, others (3.01%, phrynoderma (2.70%, lichen planus (2.58%, contact dermatitis (1.57% and ichthyosis (1.45%. Conclusion: There is a need to emphasize on training the management of common pediatric dermatoses to dermatologists, general practitioners and pediatricians for early treatment.

  4. Demodicosis: a clinicopathological study.

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    Hsu, Chao-Kai; Hsu, Mark Ming-Long; Lee, Julia Yu-Yun

    2009-03-01

    Demodex mites are common commensal organisms of the pilosebaceous unit in human beings and have been implicated in pityriasis folliculorum, rosacea-like demodicosis, and demodicosis gravis. We sought to describe the spectrum of clinicopathological findings and therapeutic responses of demodicosis in Taiwanese patients. We conducted a retrospective study to review clinicopathologic findings and therapeutic responses of 34 cases of diagnosed demodicosis. Fifteen cases with positive results of potassium hydroxide examination, standardized skin surface biopsy specimen, and/or skin biopsy specimen, and resolution of skin lesions after anti-Demodex treatment were included for final analysis. Nineteen cases were excluded because of insufficient positive data to make a definite diagnosis. There were 4 male and 11 female patients (age 1-64 years, mean age 38.7 years). The disease was recurrent or chronic with a duration ranging from 2 months to 5 years (mean 15.7 months). The skin lesions were acne rosacea-like (n = 8), perioral dermatitis-like (n = 5), granulomatous rosacea-like (n = 1), and pityriasis folliculorum (n = 1). Skin biopsy was performed in 7 patients. Overall, the histopathology was characterized by: (1) dense perivascular and perifollicular lymphohistiocytic infiltrates, often with abundant neutrophils and occasionally with multinucleated histiocytes; (2) excessive Demodex mites in follicular infundibula; and (3) infundibular pustules containing mites or mites in perifollicular inflammatory infiltrate. The skin lesions resolved after treatment including systemic metronidazole, topical metronidazole, crotamiton, or gamma benzene hexachloride. Small sample size and a fraction of patients without long-term follow-up are limitations. Demodicosis should be considered in the differential diagnosis of recurrent or recalcitrant rosacea-like, granulomatous rosacea-like, and perioral dermatitis-like eruptions of the face. Potassium hydroxide examination, standardized

  5. Significance of clinicopathological correlation in psoriasis

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    Gopal Ambadasrao Pandit

    2015-01-01

    Full Text Available Context: Psoriasis affects about 1.5% to 3% of world′s population. Other papulosquamous dermatoses are Pityriasis rosea, Lichen planus, Seborrheic dermatitis, Pityriasis rubra pilaris and Parapsoriasis. Drug eruptions, tinea corporis, and secondary syphilis may also have papulosquamous morphology. Because all papulosquamous disorders are characterized by scaling papules, clinical confusion may result during their diagnosis. Separation of each of these becomes important because the treatment and prognosis for each tends to be disease-specific. Aim: To study the pattern of clinical and histopathological features of psoriasis of the skin with clinicopathological correlation. Material and methods: The present study of 42 cases of psoriasis of the skin was carried out in the Department of Pathology of a tertiary care centre from December 2009 to October 2011. In this study, the patients which were clinically diagnosed as psoriasis of skin, before starting the treatment and attending the outdoor skin department were selected. Histopathological findings were interpreted in light of clinical details. Results: Out of 42 cases of psoriasis 24 (57.14% were males, 18 (42.86% were females with male to female ratio of 1.33:1. Mean age was 34.45 years. Maximum number of cases 22 (52.38% were encountered in 3rd and 4th decade of life. Histopathological findings: parakeratosis, acanthosis, suprapapillary thinning, Munro microabscesses and hypogranulosis were noted in most of the cases. Conclusion: Histopathology serves as a diagnostic tool and rules out other lesions which mimic psoriasis. The most accurate diagnosis is the one that most closely correlates with clinical outcome and helps to direct the most appropriate clinical intervention.

  6. [The history of dandruff and dandruff in history. A homage to Raymond Sabouraud].

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    Saint-Léger, D

    1990-01-01

    In one of his books, written at the beginning of this century, Raymond Sabouraud devotes some 280 pages to the history of dandruff. Their reading illustrates how, from the Greeks to Sabouraud's era, this desquamative disease has been subjected to endless doctrinal and scientific conflicts, long before the so-called "present" controversies. One of the early conflicts, between Celsus and Galen, lies in the nature of the squames, i. e. dry or exudating, leading to the inclusion (or non inclusion) or pityriasis in the group of desquamative diseases, such as psoriasis or ichytosis. Translated into Latin (furfur, porrigo) and into Arabic, the word pityriasis was replaced in the Middle Age by tinea which then referred to any disease of the human scalp. With Plenk, Lorry, Willan and others, the 18th century brought a new attitude of mind where observation took precedence over doctrine, but owing to the lack of experimental approach there was no adequate description of the squames and their anatomical origin. This was the case with Hebra who, in the 19th century, claimed that dandruff was nothing but a sebaceous disease. This major turn resulted for decades in a confusion between dandruff and seborrhoea. In the late 19th century, bacteriological studies were decisive steps taken by Rivolta, Malassez and Sabouraud. The presence on scalps affected with dandruff of a bottle-shaped "fungus" (Pityrosporum ovale was initially not regarded as a yeast) was taken as being the definite cause of the disease. The Sabouraud dogma was born, but as early as 1877 it was denied by Vidal who observed these "spores" on healthy scalps.(ABSTRACT TRUNCATED AT 250 WORDS)

  7. Origin Use of CD4, CD8, and CD1a Immunostains in Distinguishing Mycosis Fungoides from its Inflammatory Mimics: A Pilot Study

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    Rajalakshmi Tirumalae

    2012-01-01

    Full Text Available Patch-stage/early mycosis fungoides (MF is difficult to differentiate from benign dermatoses, despite several robust histologic criteria. Most studies include advanced lesions and data about early disease is limited. Objectives: (1 To compare the CD4:CD8 ratio in patch-stage MF versus inflammatory mimics. (2 To study patterns of CD1a expression in the epidermis and dermis in the two groups. Materials and Methods: Twenty cases each of early MF and inflammatory dermatoses were selected. The diagnoses were established after clinicopathologic correlation, repeat biopsies, and follow-up. The inflammatory group included pityriasis lichenoides chronica, actinic reticuloid, lichenoid purpura, and various psoriasiform dermatoses. Immunohistochemistry was done for CD4, CD8, and CD1a. Epidermal CD4, CD8 cells were quantified and CD1a was graded semi-quantitatively in the epidermis and dermis. Results: The average CD4:CD8 ratio was 4.2 in MF (range: 1-16.8, and 0.9 in inflammatory diseases (range: 0.43-5, which was statistically significant (P 1. CD1a cells had a continuous or confluent epidermal pattern in almost all cases of MF, while they occurred as small or large groups in the dermis. In inflammatory dermatoses, there were either isolated or scattered CD1a+ cells in both epidermis and dermis. Conclusions: Elevated CD4:CD8 ratio favors MF. But there is an overlap in the lower range with pityriasis lichenoides chronica. These cases require good clinicopathologic correlation and follow-up. Patterns of CD1a expression are more reliable. Immunostains buttress morphology and are a valuable addition.

  8. The spectrum of dermatological disorders among primary school children in Dar es Salaam

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    Mgonda Yassin M

    2010-12-01

    Full Text Available Abstract Background Dermatologic disorders are common in many countries but the spectrum varies greatly. Many studies have reported a significant burden of skin diseases in school children. The objective of this study was to determine the current spectrum of dermatological disorders in primary school children in Dar es Salaam city. Methods Primary school children were recruited by multistage sampling. Detailed interview, dermatological examination and appropriate laboratory investigations were performed. Data was analyzed using the 'Statistical Package for Social Sciences' (SPSS program version 10.0 and EPI6. A p-value of Results A total of 420 children were recruited (51% males; mean age 11.4 ± 2.8 years; range 6-19 years. The overall point prevalence of any skin disorder was 57.3% and it was 61.9% and 52.6% in males and females respectively (p = 0.05. Infectious dermatoses accounted for 30.4% with superficial fungal infections (dermatophytoses and pityriasis versicolor being the commonest (20%. Dermatophytoses were diagnosed in 11.4% (48/420; the prevalence in males and females being 12.6% and 10.1% respectively (p = 0.41 and higher (21.8% in the age-group 6-10 years (p = 0.045. Fungal cultures were positive in 42/48 children (88%. All three dermatophyte genera were isolated. Tinea capitis was the commonest disease among culture-positive dermatophytoses (30/42; 71.4% with an overall prevalence of 7.1% (30/420 followed by tinea pedis (11/42; 26.1% whose overall prevalence was 2.6%. Microsporum canis was common in tinea capitis (14/30; 46.7% followed by Trichophyton violaceum (6/30; 20%. Trichophyton rubrum was common in tinea pedis (5/11; 45.5%. Thirty six children (8.6% had pityriasis versicolor which was more prevalent (6/27; 22.l2% in the age group 16-19 years (p = 0.0004. The other common infectious dermatoses were pyodermas (4% and pediculosis capitis (3.6%. Common non-infectious dermatoses were: acne vulgaris (36.4%, non

  9. The efficacy and safety of sertaconazole cream (2 %) in diaper dermatitis candidiasis.

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    Bonifaz, Alexandro; Tirado-Sánchez, Andrés; Graniel, María José; Mena, Carlos; Valencia, Adriana; Ponce-Olivera, Rosa María

    2013-04-01

    Diaper dermatitis (DD) is an inflammatory irritating condition that is common in infants. Most cases are associated with the yeast colonization of Candida or diaper dermatitis candidiasis (DDC), and therefore, the signs and symptoms improve with antimycotic treatment. Sertaconazole is a broad-spectrum third-generation imidazole derivative that is effective and safe for the treatment for superficial mycoses, such as tineas, candidiasis, and pityriasis versicolor. Our goal was to assess the efficacy and safety of sertaconazole cream (2 %) in DDC. Twenty-seven patients with clinical and mycological diagnosis of DDC were enrolled and treated with 2 daily applications for 14 days and were followed-up for 2 further weeks. Three etiologic agents were isolated: Candida albicans in 88.8 %, Candida parapsilosis in 7.3 %, and Candida glabrata in 3.2 %. There was an average symptom reduction from 7.1 to 3.2 in the middle of treatment and to 1.2 and 0.4 units at the end of treatment and follow-up, respectively. The treatment evaluation at the end of the follow-up period showed a total clinical and mycological cure in 88.8 %, improvement in 3.7 %, and failure in 7.4 %. There was side effect (3.7 %) of skin irritation, but the drug was not discontinued. Based on its safety and effectiveness, sertaconazole cream may be considered a new alternative for DDC treatment.

  10. Wong-Type Dermatomyositis Showing Porokeratosis-Like Changes (Columnar Dyskeratosis: A Case Report and Review of the Literature

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    Nicole Umanoff

    2015-01-01

    Full Text Available Background: Wong-type dermatomyositis (DM exhibits simultaneous pityriasis rubra pilaris (PRP features. Case Report: A 50-year-old woman presented with a heliotrope rash, Gottron's papules, and a poikilodermic, erythematous rash in shawl distribution without evidence of muscle weakness. Despite topical corticosteroids, the eruption progressed 9 months later to include generalized hyperkeratotic follicular papules, islands of sparing, and atrophic macules with a collarette of scale suggestive of porokeratosis. Mild dysphonia was the only sign of muscle weakness. Serology showed positive ANA. Histopathology revealed interface dermatitis with dermal mucin and melanophages, irregular psoriasiform hyperplasia, alternating mounds of para- and orthokeratosis, and tiers of dyskeratotic cells (columnar dyskeratosis. Systemic corticosteroid therapy was not tolerated; acitretin diminished the hyperkeratosis. While hyperpigmentation persisted, no progression of cutaneous or muscular symptoms has occurred after 22 months of follow-up and cessation of the therapy. Overall, her course did not differ from the natural history documented in the literature review of Wong-type DM. The most similar case also exhibited pseudocornoid lamella changes. Conclusion: Wong-type DM is a clinicopathologic DM-PRP hybrid that can also exhibit porokeratosis-like features best described as columnar dyskeratosis. Recognizing these types of lesions in DM is warranted in order to make an accurate assessment of their prognostic significance.

  11. Prevalence of skin disorders in primary and secondary school age children in Canakkale, Turkey: a community-based survey

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    Aysegul Uludağ

    2016-06-01

    Full Text Available Introduction: Skin lesions may be of dermatological importance, affect appearance, and cause problems communicating with peers and may be especially more significant in childhood. Aim :Information on the prevalence of pediatric dermatoses in Western Turkey. This study was aimed to define the existing data. Material and methods : A cross-sectional study was conducted in Canakkale, Turkey, in September-December 2013. It involved 1,957 students from five randomly selected primary and secondary schools. Each student was interviewed for age, gender, and family history, and a dermatologic examination was performed by a dermatologist. Data were coded and analyzed. Results :Of the students, 79.9% revealed at least one dermatosis. The most common disease was benign neoplasms (76%, followed by pigmentary disorders (26.8%, and xerosis (5.8%. In primary schools, the acquired melanocytic nevus, hypopigmented macule, and xerosis; in secondary school the acne was statistically significantly more common. Acne and xerosis was more common in girls, and pityriasis alba was statistically more common in boys. Students who had at least one dermatosis were positively correlated with monthly income. Conclusions :In Turkish school age children, the prevalence of dermatosis is 79.9%. It may be due to not using preventive means for adequate protection from the sun and other environmental factors. Infectious dermatosis and atopic dermatitis are rare and it may depend on the adequacy of public health work.

  12. The role of L-DOPA on melanization and mycelial production in Malassezia furfur.

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    Sirida Youngchim

    Full Text Available Melanins are synthesized by organisms of all biological kingdoms and comprise a heterogeneous class of natural pigments. Certain of these polymers have been implicated in the pathogenesis of several important human fungal pathogens. This study investigated whether the fungal skin pathogen Malassezia furfur produces melanin or melanin-like compounds. A melanin-binding monoclonal antibody (MAb labelled in vitro cultivated yeast cells of M. furfur. In addition, melanization of Malassezia yeasts and hyphae was detected by anti-melanin MAb in scrapings from patients with pityriasis versicolor. Treatment of Malassezia yeasts with proteolytic enzymes, denaturant and concentrated hot acid yielded dark particles and electron spin resonance spectroscopy revealed that these particles contained a stable free radical compound, consistent with their identification as melanins. Malassezia yeasts required phenolic compounds, such as L-DOPA, in order to synthesize melanin. L-DOPA also triggered hyphal formation in vitro when combined with kojic acid, a tyrosinase inhibitor, in a dose-dependent manner. In this respect, L-DOPA is thought to be an essential substance that is linked to both melanization and yeast-mycelial transformation in M. furfur. In summary, M. furfur can produce melanin or melanin-like compounds in vitro and in vivo, and the DOPA melanin pathway is involved in cell wall melanization.

  13. Eczema in North West of Libya

    Science.gov (United States)

    Arshah, TM; Shambesh, MK; Grera, AM; AlBaccush, M

    2008-01-01

    The life style and demographic structure of Libyan society is changing, and this could affect the epidemiology of certain diseases, including eczema. The aim of this study was to assess the burden of eczema among a selected patient population in the Zliten area in the northwest of Libya. We conducted a retrospective study by reviewing case notes and records in public and private dermatology practices in the Zliten area. The frequency of eczema among patients attending dermatology clinics in the Zliten area was 12.8%, and the male to female ratio was almost 1:1. The most affected age group among patients was 20-29 years. Eczema represented a larger proportion of dermatologic conditions during spring and summer. Of all cases of eczema, 72.6% were endogenous and 24.9% were exogenous (p<0.001). The most common type of eczema was contact dermatitis (22.7% of all cases), followed by atopic dermatitis (19.7%) and pityriasis alba (10.5%). In conclusion, eczema is a public health problem in Zliten-Libya, and this necessitates prospective studies to determine its incidence and prevalence. PMID:21499454

  14. Lipid Metabolic Versatility in Malassezia spp. Yeasts Studied through Metabolic Modeling.

    Science.gov (United States)

    Triana, Sergio; de Cock, Hans; Ohm, Robin A; Danies, Giovanna; Wösten, Han A B; Restrepo, Silvia; González Barrios, Andrés F; Celis, Adriana

    2017-01-01

    Malassezia species are lipophilic and lipid-dependent yeasts belonging to the human and animal microbiota. Typically, they are isolated from regions rich in sebaceous glands. They have been associated with dermatological diseases such as seborrheic dermatitis, pityriasis versicolor, atopic dermatitis, and folliculitis. The genomes of Malassezia globosa, Malassezia sympodialis, and Malassezia pachydermatis lack the genes related to fatty acid synthesis. Here, the lipid-synthesis pathways of these species, as well as of Malassezia furfur, and of an atypical M. furfur variant were reconstructed using genome data and Constraints Based Reconstruction and Analysis. To this end, the genomes of M. furfur CBS 1878 and the atypical M. furfur 4DS were sequenced and annotated. The resulting Enzyme Commission numbers and predicted reactions were similar to the other Malassezia strains despite the differences in their genome size. Proteomic profiling was utilized to validate flux distributions. Flux differences were observed in the production of steroids in M. furfur and in the metabolism of butanoate in M. pachydermatis. The predictions obtained via these metabolic reconstructions also suggested defects in the assimilation of palmitic acid in M. globosa, M. sympodialis, M. pachydermatis, and the atypical variant of M. furfur, but not in M. furfur. These predictions were validated via physiological characterization, showing the predictive power of metabolic network reconstructions to provide new clues about the metabolic versatility of Malassezia.

  15. Identification of malassezia species

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    Kindo A

    2004-01-01

    Full Text Available Malassezia spp. are lipophilic unipolar yeasts recognized as commensals of skin that may be pathogenic under certain conditions. The genus Malassezia now comprises of seven species. This study was aimed at using a simple practical approach to speciate Malassezia yeasts from clinical material. Seventy skin scrapings from patients with pityriasis versicolor infection, positive in 10% potassium hydroxide (KOH, were cultured onto modified Dixon′s agar (mDixon′s agar and Sabouraud dextrose agar (SDA and incubated at 32ºC. Speciation was done on the basis of Gram stain morphology, catalase test, and utilization of Tweens. Out of 70 scrapings 48 (68.75% showed growth on mDixon′s agar. The commonest isolate was M. sympodialis (28, 58% followed by M. globosa (19, 40% and one isolate was (2% of M. restricta. M. sympodialis was the commonest species affecting our population and there was no isolation of M. obtusa, M. slooffiae, M. pachydermatis and M. furfur.

  16. Clinical effect observation of Fukang Shuang in treating steroid dependent dermatitis%肤康霜治疗激素依赖性皮炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    罗丽

    2016-01-01

    激素依赖性皮炎是一种继发性皮肤病,多发于痤疮、过敏性皮炎、单纯糠疹。皮肤瘙痒等一些疾病因长期滥用激素类药膏(如皮炎平霜,服轻松软膏等),而引起局部皮肤潮红,毛孔变粗,毛细血管扩张,并伴有少量色素沉着等副作用。应用肤康霜局部外涂,3次/ d,取得较好疗效,治疗中没发现任何不良反应。%Steroid dependent dermatitis is secondary skin disease, which is prone to acne, allergic dermatitis, pityriasis alba. It refers to skin itching due to long-term abuse of hormone cream (such as Dermatitis cream and Easy ointment), which in turn causes side effect of local skin flushing, enlarged pores, telangiectasia and accompanied by a small amount of pigmentation. The local external coating of Fukang Shuang is applied in treating steroid dependent dermatitis, three times a day, the treatment achieves significant therapeutic effect and there is no adverse reaction in the treatment.

  17. The Prevalence and Pattern of Superficial Fungal Infections among School Children in Ile-Ife, South-Western Nigeria

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    Olaide Olutoyin Oke

    2014-01-01

    Full Text Available Fungal infections of the skin and nails are common global problems with attendant morbidity among affected individuals. Children are mostly affected due to predisposing factors such as overcrowding and low socioeconomic factors. The aim of this study was to determine the prevalence and the clinical patterns of superficial fungal infections among primary school children in Ile-Ife. A multistage sampling was conducted to select eight hundred pupils from ten primary schools in Ile-Ife. Data on epidemiological characteristics and clinical history was collected using a semistructured questionnaire and skin scrapings were done. The prevalence of superficial fungal infections among the 800 respondents was 35.0%. Male pupils constituted 51.0% of respondents while the females were 49.0%. The mean age for all the respondents was 9.42 ± 2.00. Tinea capitis was the commonest infection with a prevalence of 26.9% and tinea unguium, tinea corporis, and tinea faciei had a prevalence of 0.8%, 0.6%, and 0.5%, respectively. Tinea manuum had the least prevalence of 0.1%. Pityriasis versicolor had a prevalence of 4.4%. Microsporum audouinii was the leading organism isolated. The study shows that the prevalence of superficial fungal infection (SFI among primary school children in Ile-Ife is high with tinea capitis as the commonest SFI.

  18. The Prevalence and Pattern of Superficial Fungal Infections among School Children in Ile-Ife, South-Western Nigeria.

    Science.gov (United States)

    Oke, Olaide Olutoyin; Onayemi, Olaniyi; Olasode, Olayinka Abimbola; Omisore, Akinlolu Gabriel; Oninla, Olumayowa Abimbola

    2014-01-01

    Fungal infections of the skin and nails are common global problems with attendant morbidity among affected individuals. Children are mostly affected due to predisposing factors such as overcrowding and low socioeconomic factors. The aim of this study was to determine the prevalence and the clinical patterns of superficial fungal infections among primary school children in Ile-Ife. A multistage sampling was conducted to select eight hundred pupils from ten primary schools in Ile-Ife. Data on epidemiological characteristics and clinical history was collected using a semistructured questionnaire and skin scrapings were done. The prevalence of superficial fungal infections among the 800 respondents was 35.0%. Male pupils constituted 51.0% of respondents while the females were 49.0%. The mean age for all the respondents was 9.42 ± 2.00. Tinea capitis was the commonest infection with a prevalence of 26.9% and tinea unguium, tinea corporis, and tinea faciei had a prevalence of 0.8%, 0.6%, and 0.5%, respectively. Tinea manuum had the least prevalence of 0.1%. Pityriasis versicolor had a prevalence of 4.4%. Microsporum audouinii was the leading organism isolated. The study shows that the prevalence of superficial fungal infection (SFI) among primary school children in Ile-Ife is high with tinea capitis as the commonest SFI.

  19. The effects of the El Niño Southern Oscillation on skin and skin-related diseases: a message from the International Society of Dermatology Climate Change Task Force.

    Science.gov (United States)

    Andersen, Louise K; Davis, Mark D P

    2015-12-01

    The El Niño Southern Oscillation (ENSO) is a complex climate phenomenon occurring in the Pacific Ocean at intervals of 2-7 years. The term refers to fluctuations in ocean temperatures in the tropical eastern Pacific Ocean (El Niño [the warm phase of ENSO] and La Niña [the cool phase of ENSO]) and in atmospheric pressure across the Pacific basin (Southern Oscillation). This weather pattern is attributed with causing climate change in certain parts of the world and is associated with disease outbreaks. The question of how ENSO affects skin and skin-related disease is relatively unanswered. We aimed to review the literature describing the effects of this complex weather pattern on skin. El Niño has been associated with increases in the occurrence of actinic keratosis, tinea, pityriasis versicolor, miliaria, folliculitis, rosacea, dermatitis by Paederus irritans and Paederus sabaeus, and certain vector-borne and waterborne diseases, such as dengue fever, leishmaniasis, Chagas' disease, Barmah Forest virus, and leptospirosis, and with decreases in the occurrence of dermatitis, scabies, psoriasis, and papular urticaria. La Niña has been associated with increases in the occurrence of varicella, hand, foot, and mouth disease, and Ross River virus (in certain areas), and decreases in viral warts and leishmaniasis. Reports on the effects of ENSO on skin and skin-related disease are limited, and more studies could be helpful in the future.

  20. Disease severity scoring systems in dermatology

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    Cemal Bilaç

    2016-06-01

    Full Text Available Scoring systems have been developed to interpret the disease severity objectively by evaluating the parameters of the disease. Body surface area, visual analogue scale, and physician global assessment are the most frequently used scoring systems for evaluating the clinical severity of the dermatological diseases. Apart from these scoring systems, many specific scoring systems for many dermatological diseases, including acne (acne vulgaris, acne scars, alopecia (androgenetic alopecia, tractional alopecia, bullous diseases (autoimmune bullous diseases, toxic epidermal necrolysis, dermatitis (atopic dermatitis, contact dermatitis, dyshidrotic eczema, hidradenitis suppurativa, hirsutismus, connective tissue diseases (dermatomyositis, skin involvement of systemic lupus erythematosus (LE, discoid LE, scleroderma, lichen planoplaris, mastocytosis, melanocytic lesions, melasma, onychomycosis, oral lichen planus, pityriasis rosea, psoriasis (psoriasis vulgaris, psoriatic arthritis, nail psoriasis, sarcoidosis, urticaria, and vitiligo, have also been developed. Disease severity scoring methods are ever more extensively used in the field of dermatology for clinical practice to form an opinion about the prognosis by determining the disease severity; to decide on the most suitable treatment modality for the patient; to evaluate the efficacy of the applied medication; and to compare the efficiency of different treatment methods in clinical studies.

  1. [Active search for leprosy and other skin diseases in school children from Agua de Dios, Colombia].

    Science.gov (United States)

    Rodríguez, Gerzaín; González, Rosalba; Gonzalez, Deysy; Granados, Carolina; Pinto, Rafael; Herrera, Hilda; Gutiérrez, Luisa F; Hernández, Elkin; López, Fernando; Gómez, Yenny

    2007-01-01

    Actively searching for leprosy, other skin diseases and BCG vaccination scars amongst school children from Agua de Dios, the municipality having the highest prevalence of leprosy in Colombia. A clinical examination of the children was carried out by nurses, interns, general practitioners and experts on leprosy. Skin smear tests and skin biopsies were performed when the clinical findings suggested leprosy. Anti-phenolic glycolipid antibodies in blood were determined in special cases. 86 % of the 2 844 school children were examined; 833 had skin diseases and 16 % of these required evaluation by specialists. Four new cases of paucibacillary leprosy, two indeterminate and two primary polyneuritic cases were found. Pediculosis capitis, pityriasis alba, tinea versicolor, hypopigmented nevus, insect bites and miliaria were frequently detected. BCG vaccination scars were absent in 387 children; following several logistical problems, they were vaccinated. Four children had signs of childhood abuse. An 11-year-old girl presented hypopigmented mycosis fungoides. All diseases and conditions found were treated. The community received information regarding the results, emphasising the importance of an early diagnosis of leprosy. The incidence of leprosy found (16/10,000) was 123 times higher than the rest of the country's incidence. It is advisable to continue clinical examinations in Agua de Dios and research into risk factors for acquiring leprosy.

  2. Antifungal Activity of Jasminum sambac against Malassezia sp. and Non-Malassezia sp. Isolated from Human Skin Samples

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    Jacinta Santhanam

    2014-01-01

    Full Text Available Malassezia sp. causes skin diseases such as pityriasis versicolor, folliculitis, and atopic dermatitis. The present study aims to evaluate the antifungal activity of J. sambac or Arabian jasmine, a flowering plant abundant in the Southeast Asia against Malassezia sp. using disc diffusion and broth microdilution method. The methanol extract and essential oil from the flowers and leaves of J. sambac were, respectively, prepared using solvent extraction and hydrodistillation process. Skin samples from individuals with dandruff were cultured on Sabouraud dextrose agar overlaid with olive oil. The fungi that grew were observed microscopically, tested with Tween assimilation test, and cultured on CHROMagar (the chromogenic media pioneer to identify Malassezia sp. Out of 5 skin samples, only 2 Malassezia sp. isolates were identified based on morphology and their ability to assimilate Tween. The inhibition zones of methanol extract of flowers and leaves of J. sambac and essential oil of flowers showed potential for antifungal activity with inhibition zones of 11.10 ± 1.92, 12.90 ± 1.68, and 13.06 ± 0.26 mm, respectively, and minimum inhibitory concentration (MIC values of 80 mg/mL to 160 mg/mL and 50%, respectively. In conclusion, J. sambac may be used as an alternative treatment against Malassezia-associated skin infections.

  3. Sex Differences in the Incidence of Skin and Skin-Related Diseases in Olmsted County, Minnesota, United States, and a Comparison With Other Rates Published Worldwide

    Science.gov (United States)

    Andersen, Louise K.; Davis, Mark D. P.

    2016-01-01

    Many skin and skin-related diseases affect the sexes unequally, with attendant implications for public health and resource allocation. To better evaluate the incidence of skin and skin-related diseases affecting males versus females, we reviewed published population-based epidemiology studies of skin disorders performed utilizing Rochester Epidemiology Project (REP) data. Females had a higher incidence of the following diseases: connective tissue diseases (scleroderma, morphea, dermatomyositis, primary Sjögren syndrome, systemic lupus erythematosus [not in all studies]), pityriasis rosea, herpes progenitalis, condyloma acuminatum, hidradenitis suppurativa, herpes zoster (except in children), erythromelalgia, venous stasis syndrome, and venous ulcers. Males had a higher incidence of psoriasis and psoriatic arthritis, basal cell carcinoma (exception, females aged ≤40 years), squamous cell carcinoma, and lentigo maligna. Incidence rates were equal in males and females for cutaneous malignant melanoma (exception, higher in females aged 18–39 years), lower-extremity cellulitis, cutaneous nontuberculous mycobacterial infection, Behçet disease, delusional infestation, alopecia areata, and bullous pemphigoid. Many of the population-based sex-specific incidence rates of skin and skin-related diseases derived from the Rochester Epidemiology Project are strikingly different from those estimated elsewhere. In general, females are more commonly affected by skin and skin-related diseases. The reasons for this imbalance remain to be determined and are likely multifactorial. PMID:27009931

  4. The comparison between the efficacy of high dose acyclovir and erythromycin on the period and signs of pitiriasis rosea

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    Ehsani Amirhooshang

    2010-01-01

    Full Text Available Background: Pityriasis Rosea (PR is an acute inflammatory and self-limiting skin disorder, sometimes with troublesome symptoms. To date, there are few treatments available for this disorder. Aim: Compare the traditional treatment with erythromycin to a newly introduced antiviral treatment acyclovir for PR. Materials and Methods: Patients with clinically confirmed diagnosis of PR, matching our exclusion criteria, were enrolled. They were randomized in two groups that received high-dose oral acyclovir or erythromycin. The participants were evaluated two, four, and eight weeks after commencement of the study and followed for one year. Results: A total of 30 patients including 15 males and 15 females completed the study. After eight weeks, 13 patients in the acyclovir group experienced complete response, while in the erythromycin group only six patients had complete response (P < 0.05. Also, patients in the acyclovir group experienced faster resolution of pruritus in comparison with the erythromycin group (not significant. No adverse drug reaction was detected in both groups. Conclusion: It seemed that a high-dose of oral acyclovir was a safe and effective therapy for PR, although this remained to be confirmed in larger studies.

  5. Risk factors for mucocutaneous fungal infections in patients with type 2 diabetes mellitus

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    Düriye Deniz Demirseren

    2014-06-01

    Full Text Available Background and design: Mucocutaneous fungal infections are common in patients with diabetes mellitus (DM. However, fungal infections do not develop in every patient with DM. In this study, we aimed to determine the risk factors for developing mucocutaneous fungal infections in patients with type 2 DM. Materials and methods: A total of 302 type 2 DM patients with mucocutaneous fungal infections and 326 type 2 DM patients without mucocutaneous fungal infections were enrolled. Demographic and clinical features, HbA1c levels, DM durations, body mass indexes (BMIs, and DM related complications of patients were compared and risk factors for developing mucocutaneous fungal infections were determined. Results: Of the 302 patients with mucocutaneous fungal infections, 81.2% (n=245 had dermatophytosis, 16.9% (n=51 had candidal infections, 2.0% (n=6 had pityriasis versicolor. Frequency of male gender, diabetic nephropathy, neuropathy and retinopathy; DM durations and ages of patients were all significantly higher in diabetic patients with fungal infections than patients without fungal infections (all p<0.05. Male gender, age ≥ 50 years, nephropathy and neuropathy were independently associated with developing fungal infection in type 2 DM patients. In subgroup analyses, independent risk factors for dermatophytosis were male gender, age ≥ 50 years, DM duration ≥5 years, and nephropathy. For candidiasis, these factors were BMI≥30 and neuropathy. Conclusion: Elderly, male gender, diabetic neuropathy annd nephropathy are closely associated with developing mucocutaneous infections in patients with type 2 DM.

  6. Skin changes in patients with chronic renal failure

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    Olarenwaju Falodun

    2011-01-01

    Full Text Available Management of patients with renal failure remains a major problem in poor-resource nations. Cutaneous manifestations in this group of patients are varied and remain helpful in differentiating acute from chronic renal failure (CRF. We studied the prevalence and pattern of skin disorders in patients with CRF at The University College Hospital, Ibadan, Nigeria, during the period between May 2006 and February 2007. Relevant information was collected with the aid of a questionnaire. The patients were then examined for skin disorders. One hundred and twenty patients who met the inclusion criteria were recruited into the study. The mean age of the CRF patients was 43.12 ± 15.38 years, while that of the control subjects was 43.13 ± 15.38 years. Seventy-six of the 120 patients (63.3% were on chronic hemodialysis while 44 (36.5% were on conservative management. A total of 107 patients (89.1% had at least one skin problem. The skin disorders seen include xerosis in 72 (60%, pruritus in 32 (26.7%, hyper-pigmentation, icthyosis and pityriasis versicolor in nine patients each (7.5%, either singly or in combination. Pallor of the skin was seen in three of the patients (2.5%, while uremic frost was seen in one (0.8%. Nail changes were seen in 48 patients (40%. We conclude that xerosis, pruritus, pigmentary and nail changes were the most common skin disorders in patients with CRF in our environment.

  7. The Malassezia Genus in Skin and Systemic Diseases

    Science.gov (United States)

    Magiatis, Prokopios; Hantschke, Markus; Bassukas, Ioannis D.; Velegraki, Aristea

    2012-01-01

    Summary: In the last 15 years, the genus Malassezia has been a topic of intense basic research on taxonomy, physiology, biochemistry, ecology, immunology, and metabolomics. Currently, the genus encompasses 14 species. The 1996 revision of the genus resulted in seven accepted taxa: M. furfur, M. pachydermatis, M. sympodialis, M. globosa, M. obtusa, M. restricta, and M. slooffiae. In the last decade, seven new taxa isolated from healthy and lesional human and animal skin have been accepted: M. dermatis, M. japonica, M. yamatoensis, M. nana, M. caprae, M. equina, and M. cuniculi. However, forthcoming multidisciplinary research is expected to show the etiopathological relationships between these new species and skin diseases. Hitherto, basic and clinical research has established etiological links between Malassezia yeasts, pityriasis versicolor, and sepsis of neonates and immunocompromised individuals. Their role in aggravating seborrheic dermatitis, dandruff, folliculitis, and onychomycosis, though often supported by histopathological evidence and favorable antifungal therapeutic outcomes, remains under investigation. A close association between skin and Malassezia IgE binding allergens in atopic eczema has been shown, while laboratory data support a role in psoriasis exacerbations. Finally, metabolomic research resulted in the proposal of a hypothesis on the contribution of Malassezia-synthesized aryl hydrocarbon receptor (AhR) ligands to basal cell carcinoma through UV radiation-induced carcinogenesis. PMID:22232373

  8. Erytrodermia łuszczycowa po ogólnym zastosowaniu kortykosteroidów – opis przypadku

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    Joanna Maj

    2011-11-01

    Full Text Available Introduction. Erythroderma (exfoliative dermatitis is an acute, generalizedinflammation of the skin, which affects at least 90% of its surface.It is a life threatening illness in the course of which various types anddegrees of scaling and itching are observed. The main causes of erythrodermaare psoriasis, atopic dermatitis, drug reactions, mycosis fungoidesand pityriasis rubra pilaris. Psoriatic erythroderma is classified as a secondary erythroderma. It may develop spontaneously or moreoften as a result of incorrect treatment.Objective. To present side effects of oral corticosteroids administrationin a patient with psoriasis.Case report. A 36-year-old woman, suffering from psoriasis for over7 years, was admitted to the hospital inMarch 2011 due to exacerbationof skin lesions up to erythroderma after administration of oral corticosteroidtherapy. Three weeks after corticosteroids withdrawal, significantworsening of the disease was observed. On admission she presentedmassiveskin inflammation, scaling and itching. Laboratory testsrevealed increased markers of inflammation. The patient was treatedwith combined immunosuppressive therapy and topical ointments.After 3 weeks, significant regression of skin lesions and normalizationof laboratory tests were observed.Conclusions. Psoriasis is a common cause of erythroderma in adults.Although in Europe the disease affects about 2% of the population andknowledge of its treatment should be common, cases of systemicadministration of corticosteroids in patients with psoriasis in the treatmentof the underlying disease or of the comorbidities are still beingreported.

  9. Lewandowsky and Lutz dysplasia: Report of two cases in a family

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    Bhawna Bhutoria

    2011-01-01

    Full Text Available Lewandowsky and Lutz dysplasia, also known as epidermodysplasia verruciformis (EV, is an inherited disorder in which there is widespread and persistent infection with human papilloma virus, defect in cell-mediated immunity and propensity for malignant transformation. Differential clinical and histopathologic evolutions of lesions in two cases of familial EV are compared and discussed in detail. Cases were followed up for 7 years. Detailed history, clinical features and investigations, including skin biopsy from different sites at different times, were examined. Generalized pityriasis versicolor like hypopigmented lesions in both the cases, together with variable pigmented nodular actinic keratosis like lesions on sun-exposed areas, were present. Multiple skin biopsies done from various sites on different occasions revealed features typical of EV along with lesions, i.e., actinic keratosis, Bowen′s disease, basal and squamous cell carcinoma, in the elder sibling. However, skin biopsy of the other sibling showed features of EV and seborrheic keratosis only till date. This study reveals that the disease progression is variable among two individuals of the same family. Malignant lesions were seen only on sun-exposed areas and may be associated with other skin lesions or infections such as angiokeratoma of Fordyce and tinea cruris, as seen in this report.

  10. The Role of L-DOPA on Melanization and Mycelial Production in Malassezia Furfur

    Science.gov (United States)

    Youngchim, Sirida; Nosanchuk, Joshua D.; Pornsuwan, Soraya; Kajiwara, Susumu; Vanittanakom, Nongnuch

    2013-01-01

    Melanins are synthesized by organisms of all biological kingdoms and comprise a heterogeneous class of natural pigments. Certain of these polymers have been implicated in the pathogenesis of several important human fungal pathogens. This study investigated whether the fungal skin pathogen Malassezia furfur produces melanin or melanin-like compounds. A melanin-binding monoclonal antibody (MAb) labelled in vitro cultivated yeast cells of M. furfur. In addition, melanization of Malassezia yeasts and hyphae was detected by anti-melanin MAb in scrapings from patients with pityriasis versicolor. Treatment of Malassezia yeasts with proteolytic enzymes, denaturant and concentrated hot acid yielded dark particles and electron spin resonance spectroscopy revealed that these particles contained a stable free radical compound, consistent with their identification as melanins. Malassezia yeasts required phenolic compounds, such as L-DOPA, in order to synthesize melanin. L-DOPA also triggered hyphal formation in vitro when combined with kojic acid, a tyrosinase inhibitor, in a dose-dependent manner. In this respect, L-DOPA is thought to be an essential substance that is linked to both melanization and yeast-mycelial transformation in M. furfur. In summary, M. furfur can produce melanin or melanin-like compounds in vitro and in vivo, and the DOPA melanin pathway is involved in cell wall melanization. PMID:23762233

  11. Leprosy in Buriticupu, state of Maranhão: active search in the general population

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    Antonio Rafael da Silva

    2012-04-01

    Full Text Available INTRODUCTION: This study was developed to evaluate the situation of leprosy in the general population of the municipality of Buriticupu, State of Maranhão, Brazil. METHODS: We used the method of active search to identify new cases from 2008 to 2010. Bacilloscopy of intradermal scrapings was performed in all patients with skin lesions compatible with leprosy, and histopathological examination in those who had doubts on the definition of the clinical form. RESULTS: The study included 19,104 individuals, with 42 patients diagnosed with leprosy after clinical examination, representing a detection rate of 219.84 per 100,000 inhabitants. The predominant clinical presentation was tuberculoid with 24 (57.1% cases, followed by borderline with 11, indeterminate with four, and lepromatous with three cases. The study also allowed the identification of 81 patients with a history of leprosy and other skin diseases, such as pityriasis versicolor, dermatophytosis, scabies, vitiligo, and skin carcinoma. The binomial test showed that the proportion of cases in the headquarters was significantly higher than that in the villages (p = 0.04, and the generalized exact test showed that there was no association between age and clinical form (p = 0.438 and between age and gender (p = 0.083. CONCLUSIONS: The elevated detection rate defines the city as hyperendemic for leprosy; the active search for cases, as well as the organization of health services, is an important method for disease control.

  12. The hair strand test - a new method for testing antifungal effects of antidandruff preparations.

    Science.gov (United States)

    Mayser, Peter; Argembeaux, Horst; Rippke, Frank

    2003-01-01

    Seborrheic dermatitis and its minimal variant, dandruff (pityriasis simplex capillitii), are among the most frequent diseases caused by Malassezia (M.) yeasts. Treatment studies have shown that antimycotics achieve clinical improvement, while recolonization leads to recurrent symptoms. Among the antimycotics used are azoles, hydroxypyridones, and various agents such as zinc pyrithione, tar, and selenium disulfide. However, comparative efficacy studies in vitro should not only consider the minimal inhibitory concentrations against Malassezia yeasts but also the bioavailability of the individual substances with regard to hair and scalp. By means of a new method, the hair strand test, hairs from ten volunteers were subjected to standardized 5-min incubation with different shampoo formulations. Thereafter they were rinsed with running water for 1 min and dried. Two hundred each of these hairs (length 1 cm) were given into a medium (olive oil on selective agar for pathogenic fungi) inoculated with M. sympodialis or M. globosa (5 x 10(3) CFU/microl), and the influence on growth was semiquantitatively determined over a period of up to 18 days. According to preliminary results, 1% climbazole proved to be particularly effective. The hair strand test, which can also be performed ex vivo, is a new method to find out whether antimycotic agents bind differently to the hair substance and, via a depot effect, may influence the growth of Malassezia yeasts and thus affect dandruff. This allows conclusions about the efficacy of antidandruff formulations.

  13. Characterization of the fungal microbiota (mycobiome in healthy and dandruff-afflicted human scalps.

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    Hee Kuk Park

    Full Text Available The human scalp harbors a vast community of microbial mutualists, the composition of which is difficult to elucidate as many of the microorganisms are not culturable using current culture techniques. Dandruff, a common scalp disorder, is known as a causative factor of a mild seborrheic dermatitis as well as pityriasis versicolor, seborrheic dermatitis, and atopic dermatitis. Lipophilic yeast Malassezia is widely accepted to play a role in dandruff, but relatively few comprehensive studies have been reported. In order to investigate fungal biota and genetic resources of dandruff, we amplified the 26S rRNA gene from samples of healthy scalps and dandruff-afflicted scalps. The sequences were analyzed by a high throughput method using a GS-FLX 454 pyrosequencer. Of the 74,811 total sequence reads, Basidiomycota (Filobasidium spp. was the most common phylum associated with dandruff. In contrast, Ascomycota (Acremonium spp. was common in the healthy scalps. Our results elucidate the distribution of fungal communities associated with dandruff and provide new avenues for the potential prevention and treatment of dandruff.

  14. 马拉色菌属的研究进展%Study Progress of Malassezia

    Institute of Scientific and Technical Information of China (English)

    拓江; 路永红

    2011-01-01

    马拉色菌是一种寄生于人和动物正常皮肤表面的真菌,可导致机会感染而引起各种马拉色菌属相关疾病.马拉色菌的致病机制主要是分解脂质,导致角质形成细胞形态学改变和细胞凋亡.马拉色菌可引起花斑癣、脂溢性皮炎、马拉色菌毛囊炎等,在特应性皮炎中也起到变应原的作用.对于这些疾病的治疗可使用抗真菌药物.%Malassezia is a sort of parasitic fungus in the surface of normal skin of humans and animals,it can lead to opportunistic infections and cause a variety of Malassezia-related diseases. Malassezia can decompose lipids,and result in morphological changes of keratinocytes and apoptosis, which is its main etiological factor. Malassezia can cause pityriasis versicolor, seborrheic dermatitis, Malassezia folliculitis, etc. In atopic dermatitis, it may play a role as allergen. For the treatment of these diseases , antifungal medicine can be used.

  15. The Prevalence and Pattern of Superficial Fungal Infections among School Children in Ile-Ife, South-Western Nigeria

    Science.gov (United States)

    Oke, Olaide Olutoyin; Onayemi, Olaniyi; Olasode, Olayinka Abimbola; Omisore, Akinlolu Gabriel; Oninla, Olumayowa Abimbola

    2014-01-01

    Fungal infections of the skin and nails are common global problems with attendant morbidity among affected individuals. Children are mostly affected due to predisposing factors such as overcrowding and low socioeconomic factors. The aim of this study was to determine the prevalence and the clinical patterns of superficial fungal infections among primary school children in Ile-Ife. A multistage sampling was conducted to select eight hundred pupils from ten primary schools in Ile-Ife. Data on epidemiological characteristics and clinical history was collected using a semistructured questionnaire and skin scrapings were done. The prevalence of superficial fungal infections among the 800 respondents was 35.0%. Male pupils constituted 51.0% of respondents while the females were 49.0%. The mean age for all the respondents was 9.42 ± 2.00. Tinea capitis was the commonest infection with a prevalence of 26.9% and tinea unguium, tinea corporis, and tinea faciei had a prevalence of 0.8%, 0.6%, and 0.5%, respectively. Tinea manuum had the least prevalence of 0.1%. Pityriasis versicolor had a prevalence of 4.4%. Microsporum audouinii was the leading organism isolated. The study shows that the prevalence of superficial fungal infection (SFI) among primary school children in Ile-Ife is high with tinea capitis as the commonest SFI. PMID:25574161

  16. Identification of Malassezia Species Isolated from Patients with Seborrheic Dermatitis Using PCR-RFLP Method in Arak, Iran

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    Mohajerani, HR. (PhD

    2015-01-01

    Full Text Available Background and Objective: Malassezia that is a part of normal flora is lipophilic yeast involved in a variety of skin diseases such as seborrheic dermatitis, pityriasis versicolor, atopic dermatitis and psoriasis. Seborrheic dermatitis affects most often the sebaceous-gland-rich areas of skin such as face, scalp, and parts of the upper trunk. Dandruff is a mild variant of seborrheic dermatitis characterized by scaling. In this study, Malassezia species causing dandruff were identified. Material and Methods: In this descriptive study, the samples (n= 60 from participants with dandruff were examined under a microscope using 10% KOH solution and cultured in Leeming and Notman ager medium. DNA Extraction was performed from colonies by glass bead and the Malassezia genus, and species were detected by CfoI enzyme using PCR-RFLP method Results: Of 60, 40 (66.6% were positive for Malassezia yeast. The positive samples in direct examination grew in culture medium. Malassezia species isolated were Malassezia globosa (25 cases, Malassezia restricta (10 cases, Malassezia furfur (3 cases and Malassezia sympodialis (2 cases. Conclusions: In most studies, the Malassezia species were identified as the agents causing seborrheic dermatitis. In our study, Malassezia globosa was isolated as a dominant species.

  17. A Study of Superficial Mycosis in South Gujarat Region

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    Parul Patel, Summaiya Mulla, Disha Patel, Gaurishankar Shrimali

    2010-12-01

    Full Text Available Aim: To know the seroprevalence of clinical pattern of dermatophytosis and non – dermatophytic fungi (superficial mycosis with most common fungal pathogen in the South Gujarat region of the India. Methods: A clinical and mycological study of superficial mycosis was conducted on 198 cases (127 male and 71 female. Direct microscopy by KOH mount and culture was undertaken to isolate the fungal pathogen in each case. Results: 123 out of 198 cases (62.12% were positive by direct microscopy in which 58 (29.29% were positive by culture. The commonest age group involved was 21 – 30 years. Tinea corporis was the most common clinical presentation and Trichopyton rubrum was the most common fungal pathogen isolated. Non dermatophytic fungus like pityriasis versicolor and yeast like candida species were isolated in 17(22.67% cased and 8 (10.67% cases respectively. Conclusion: It was concluded that along with dermatophytes, nondermatophytic fungi are also emerging as important causes of superficial mycosis.

  18. Assessment of TCR-beta clonality in a diverse group of cutaneous T-Cell infiltrates.

    Science.gov (United States)

    Plaza, Jose Antonio; Morrison, Carl; Magro, Cynthia M

    2008-04-01

    While some unequivocally benign infiltrates are easy to distinguish from cutaneous T-cell lymphoma (CTCL), drug-associated lymphomatoid hypersensitivity reaction and cutaneous lesions of collagen vascular disease can show cytologic atypia, clonality and an immunophenotypic profile that closely simulates CTCL and cause diagnostics difficulties. Similar immunophenotypic and molecular abnormalities to those of malignant lymphoma can also be observed in pityriasis lichenoides chronica (PLC), large plaque parapsoriasis (LPP), pigmented purpuric dermatosis (PPD) and atypical lymphocytic lobular panniculitis leading one to consider these entities as forms of cutaneous lymphoid dyscrasia. The purpose of our study was to evaluate the distinction of these various subcategories of cutaneous T-cell infiltrates by assessment of T-cell receptor (TCR)-beta gene rearrangement. Formalin-fixed paraffin-embedded skin biopsies from 80 patients containing a T-cell dominant lymphocytic infiltrate were analyzed for TCR-beta gene rearrangement. Our findings indicate that monoclonality is a reliable characteristic of CTCL with polyclonality being very infrequent. However, some cases of drug associated lymphomatoid hypersensitivity, collagen vascular disease and the various cutaneous lymphoid dyscrasias (i.e. PLC, PPD and atypical lymphocytic lobular panniculitis) could manifest restricted molecular profiles in the context of an oligoclonal process or frank monoclonality.

  19. Recent trends in specular light reflectance beyond clinical fluorescence diagnosis.

    Science.gov (United States)

    Szepetiuk, Grégory; Piérard, Sébastien; Pierard-Franchimont, Claudine; Caucanas, Marie; Quatresooz, Pascale; Pierard, Gérald E

    2011-01-01

    Under specific light illumination, particularly ultraviolet (UV) and near-UV light stimulation, the skin produces both specular light reflectance and, possibly, specific fluorescent emission. These properties offer diagnostic clues and disclose some peculiar functions of the skin. A series of superficial infections (erythrasma, some tinea capitis types, tinea/pityriasis versicolor, dermatophytoses, etc.) and pilosebaceous follicles enriched in Propionibacterium spp show fluorescence. This latter characteristic is downgraded or lost while on some anti-acne treatments. A quenching effect of fluorescence is observed following the application of sunscreens. The (pre)neoplastic areas prepared for methylaminolevulinate photodynamic therapy (MAL-PDT) show reddish fluorescence following drug metabolisation producing porphyrins by the abnormal activated cells. Of note, when using a recording sensitive CCD camera instead of casual visual observation, skin fluorescence may be superimposed on the specular reflectance of the incident light. With the current technology, these situations are not distinguished with confidence. Any harsh and scaly lesion appears brighter following yellowish specular light reflectance. Stratum corneum samplings collected on clear self-adhesive discs or cyanoacrylate skin surface strippings are conveniently examined ex vivo, taking advantage of the same optical properties.

  20. Specialized dermatological care for marginalized populations and education at the primary care level: is community dermatology a feasible proposal?

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    Estrada, Roberto; Chavez-Lopez, Guadalupe; Estrada-Chavez, Guadalupe; Paredes-Solis, Sergio

    2012-11-01

    Skin diseases have a very high frequency either in developed as well as in undeveloped countries. Guerrero, Chiapas, and Oaxaca are the most impoverished states in Mexico, where 24% of the population lacks basic health care, and only 15% are estimated to have access to specialists. Community Dermatology program was founded in 1991 with the intention of improving the dermatological health of remote, marginalized inhabitants of the state of Guerrero. The program consists of a two-day visit to a pre-selected community; the first day includes a basic dermatology training course for local providers, and day 2 is a "Jornada",which means a day of free medical consultation and treatment. Pityriasis albus Cloasma, vitiligo, and acne continue to be the most frequent diagnosed primary disorders, as in rural areas occupational obligations include prolonged sun exposure. The experience and success of Community Dermatology over the last 20 years has demonstrated that this model of healthcare delivery and instruction is economically feasible, provides practical and quantifiable benefits for the communities served, and could be emulated by other disciplines within medicine.

  1. Crusted Demodicosis in an Immunocompetent Pediatric Patient

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    Guillermo Antonio Guerrero-González

    2014-01-01

    Full Text Available Demodicosis refers to the infestation by Demodex spp., a saprophytic mite of the pilosebaceous unit. Demodex proliferation can result in a number of cutaneous disorders including pustular folliculitis, pityriasis folliculorum, papulopustular, and granulomatous rosacea, among others. We report the case of a 7-year-old female presenting with pruritic grayish crusted lesions over her nose and cheeks, along with facial erythema, papules, and pustules. The father referred chronic use of topical steroids. A potassium hydroxide mount of a pustule scraping revealed several D. folliculorum mites. Oral ivermectin (200 μg/kg, single dose plus topical permethrin 5% lotion applied for 3 consecutive nights were administered. Oral ivermectin was repeated every week and oral erythromycin plus topical metronidazole cream was added. The facial lesions greatly improved within the following 3 months. While infestation of the pilosebaceous unit by Demodex folliculorum mites is common, only few individuals present symptoms. Demodicosis can present as pruritic papules, pustules, plaques, and granulomatous facial lesions. To our knowledge, this is the first reported case of facial crusted demodicosis in an immunocompetent child. The development of symptoms in this patient could be secondary to local immunosuppression caused by the chronic use of topical steroids.

  2. A study of skin disorders in patients with primary psychiatric conditions

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    Kuruvila Maria

    2004-09-01

    Full Text Available BACKGROUND: The skin occupies a powerful position as an organ of communication and plays an important role in socialization throughout life. The interface between dermatology and psychiatry is complex and of clinical importance. AIMS: To document the incidence of cutaneous disorders in patients with primary psychiatric conditions. METHODS: Three hundred patients with a primary psychiatric condition who had cutaneous disease were entered into the study group. The patients were classified appropriately based on the classification of psychocutaneous disorders. The control group included 300 patients presenting with a skin disorder and without any known psychiatric complaint. RESULTS: The majority of the cases in the study group were in the 3rd-5th decade. In this study, the most common primary psychiatric conditions were manic depressive psychosis (53.33%, depression (36.33%, schizophrenia (8.33% and anxiety (2%. Of the study group, 68.66% patients had infective dermatoses and the rest had non-infective dermatoses. A high incidence of pityriasis versicolor and dermatophyte infections was noted in males from the study group. Among non-infective dermatoses, 8% had eczema, and psychogenic skin disorders were seen in 4.67% of the study group. Of these, delusions of parasitosis were the commonest (2% followed by venereophobia (1%. CONCLUSIONS: A statistically significant higher incidence of tinea versicolor and dermatophyte infections was seen in the study group. Delusion of parasitosis was the most common psychogenic skin disorder seen in the study group, followed by venereophobia.

  3. Micoses superficiais na cidade de Manaus, AM, entre março e novembro/2003 Superficial mycoses in the City of Manaus/AM between March and November/2003

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    José Augusto Almendros de Oliveira

    2006-06-01

    /CPCS-INPA. RESULTS - Three hundred and ninety-four examinations were carried out throughout the period and 256 were positive. The mycoses with higher incidence were onychomycosis (135 and pityriasis versicolor (98. The most often isolated agents were Malassezia spp. (77 and Candida spp. (72. Tinea capitis was more frequent in pre-school children (3 and onychomycosis in adults (94. Mycoses were more prevalent in women (91. All socioeconomic classes were affected, with a predominance in class C (37. CONCLUSION - Onychomycosis and pityriasis versicolor affected mostly adults and Tinea capitis occured mainly in children. Superficial mycoses were more predominant in women. Malassezia spp. and Candida spp. were the most often isolated agents.

  4. Random amplified polymorphic DNA combined with microfluidic chips in the identification of Malassezia species%随机扩增多态性DNA结合微流芯片鉴定马拉色菌的初步研究

    Institute of Scientific and Technical Information of China (English)

    王韵茹; 章强强

    2012-01-01

    目的 探讨微流芯片在马拉色菌鉴定与分型中的应用优势.方法 收集马拉色菌标准菌株及直接镜检阳性的花斑糠疹患者皮损处皮屑及马拉色菌毛囊炎患者皮损处毛囊内容物培养出的马拉色菌菌株进行DNA测序,鉴定菌种,随机扩增多态性DNA聚合酶链反应(RAPD-PCR)电泳分析及微流芯片基因型定量分析并聚类分析树状图.结果 共分离83株马拉色菌临床菌株,其中72株分离自花斑糠疹,11株分离自马拉色菌毛囊炎.大多数菌株均可被2种随机引物(S22、S24)扩增而获得清晰条带,但以S22引物扩增的条带更为稳定、清晰,作为主要引物.不同种马拉色菌通过微流芯片基因型定量分析得到不同大小的固定阳性条带,所有菌株均可见种间和种内多态性.在DNA测序的基础上,使用RAPD结合微流芯片方法,基本可将8种马拉色菌(糠秕、合轴、球形、厚皮、斯洛菲、日本、大和及皮肤马拉色菌)区别.结论 RAPD结合微流芯片方法作为一种快速、高通量、高灵敏性的分析技术,在马拉色菌种间菌株遗传多样性、亲缘关系的分析及新种鉴定中显示出一定优越性.%Objective To evaluate the performance of microfluidic chips in the identification and genotyping of Malassezia species.Methods This study included 6 reference Malassezia strains and clinical Malassezia isolates from the scrapings of patients with pityriasis versicolor and follicular contents of patients with Malassezia folliculitis.These isolates were identified by DNA sequencing,random amplified polymorphic DNA (RAPD)-PCR and microfluidic chips.Cluster analysis was carried out and tree diagrams were generated.Results A total of 83 Malassezia isolates were obtained from 72 patients with pityriasis versicolor and 11 patients with Malassezia folliculitis.Genomic DNA of most strains was successfully amplified by PCR with two primers S22 and S24,and PCR with S22 primer produced more

  5. 南昌地区7251例门诊皮肤黏膜真菌病及病原菌分析%Clinical phenotype and pathogen profile of 7251 cases of cutaneous and mucous mycosis in Nanchang region

    Institute of Scientific and Technical Information of China (English)

    占萍; 李智华; 江情; 金云; 陶丽; 罗云鹏; 耿承芳

    2010-01-01

    Objective To profile the phenotype and pathogens of cutaneous and mucous mycoses in a dermatology outpatient clinic in Nanchang region. Methods A review was performed to assess cutaneous and mucous mycoses diagnosed in the dermatology outpatient clinic of Dermatology Hospital of Jiangxi Province from 2006 to 2008. The relationship of clinical phenotype and pathogens to season, patients' age and gender was analyzed. Results A total of 7251 cases were collected, and the ratio of male to female patients was 2.3: 1. The most prevalent mycoses included tinea cruris (2702, 37.1%), pityriasis versicolor (1505, 20.8%) and tinea manus (727, 10.0%). In total, 4953 fungal strains were isolated from all the patients except for those with pityriasis versicolor, of them, Trichophyton rubrum accounted to 69.9%, Candida to 20.4%, and Trichophyton violaceum to 4.5%. Season, patients' age and gender were found to be associated with clinical phenotypes and pathogens of mycoses. Conclusions In the dermatology outpatient clinic of Nanchang region, tinea cruris is the most common superficial fungal disease, with the predominant pathogen being Trichophyton rubrum. Trichophyton violaceum is the primary pathogen of tinea capitis, which is different from other reports.%目的 了解南昌地区皮肤科门诊真菌感染性疾病的构成情况.方法 统计我院门诊2006-2008年期间诊断的所有皮肤和黏膜真菌病,分析病种和致病菌种与年龄、性别和发病季节的关系.结果 皮肤和黏膜真菌病共7251例,男女比为2.3∶1.股癣2702例占37.3%、花斑糠疹1505例占20.8%,手癣727例占10.0%,分别居第1~3位.除花斑糠疹未进行培养外,培养阳性菌株4953株,优势菌为红色毛癣菌(69.9%)、念珠菌(20.4%)和紫色毛癣菌(4.5%).不同年龄段、性别及季节的病种和病原菌分布差异具有统计学意义.结论 南昌地区皮肤门诊中皮肤和黏膜真菌病以股癣病例数最多,致病菌主要为红色毛癣菌,头

  6. Rare and very rare adverse effects of clozapine

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    De Fazio P

    2015-08-01

    Full Text Available Pasquale De Fazio,1 Raffaele Gaetano,1 Mariarita Caroleo,1 Gregorio Cerminara,1 Francesca Maida,2 Antonio Bruno,3 Maria Rosaria Muscatello,3 Maria Jose Jaén Moreno,4 Emilio Russo,2 Cristina Segura-García1 1Department of Health Sciences, School of Specialization in Psychiatry, 2Department of Health Sciences, School of Specialization in Pharmacology, University “Magna Graecia”, Catanzaro, 3Department of Neurosciences, School of Specialization in Psychiatry, University of Messina, Messina, Italy; 4Department of Social Health Sciences, Radiology and Physical Medicine, University of Cordoba, Cordoba, Spain Abstract: Clozapine (CLZ is the drug of choice for the treatment of resistant schizophrenia; however, its suitable use is limited by the complex adverse effects’ profile. The best-described adverse effects in the literature are represented by agranulocytosis, myocarditis, sedation, weight gain, hypotension, and drooling; nevertheless, there are other known adverse effects that psychiatrists should readily recognize and manage. This review covers the “rare” and “very rare” known adverse effects of CLZ, which have been accurately described in literature. An extensive search on the basis of predefined criteria was made using CLZ and its combination with adverse effects as keywords in electronic databases. Data show the association between the use of CLZ and uncommon adverse effects, including ischemic colitis, paralytic ileus, hematemesis, gastroesophageal reflux disease, priapism, urinary incontinence, pityriasis rosea, intertriginous erythema, pulmonary thromboembolism, pseudo-pheochromocytoma, periorbital edema, and parotitis, which are influenced by other variables including age, early diagnosis, and previous/current pharmacological therapies. Some of these adverse effects, although unpredictable, are often manageable if promptly recognized and treated. Others are serious and potentially life-threatening. However, an adequate

  7. Dermatologic conditions in teenage adolescents in Nigeria

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    Henshaw EB

    2014-05-01

    Full Text Available Eshan B Henshaw,1 Olayinka A Olasode,2 Evelyn E Ogedegbe,3 Imaobong Etuk4 1Dermatology Unit, Department of Internal Medicine, University of Calabar, Calabar, Cross River State, 2Department of Dermatology, Obafemi Awolowo University, Ile-Ife, Osun State, 3Cedarcrest Hospital, Abuja, Federal Capital Territory, 4Department of Pediatrics, University of Calabar, Calabar, Cross River State, Nigeria Background: Skin disorders are common in adolescents, and the impact on quality of life can be enormous, particularly when viewed against the backdrop of the visibility of skin diseases and the psychologically vulnerable period of adolescence. However, few studies have documented the magnitude of skin disorders in this subset of individuals. We therefore estimated the point prevalence and pattern of dermatologic conditions in adolescents attending various secondary schools in Calabar, Southern Nigeria. Methods: Using a structured questionnaire, relevant sociodemographic information was obtained from 1,447 teenage adolescents from eight secondary schools. Thereafter, a whole body examination was conducted to determine the presence and types of skin disorders seen. Results: Skin diseases were seen in 929 students. The point prevalence was higher in males (72.1% than in females (58.3%. Private schools had a higher prevalence than public schools. The six most common dermatoses were acne vulgaris, pityriasis versicolor, nevi, tinea, miliaria, and keloid/hypertrophic scars, and accounted for over 80% of the dermatoses seen. Conclusion: The point prevalence of dermatoses in senior secondary school adolescents was 64.2%. Although a large number of skin disorders were observed, only a handful accounted for a significant proportion of the diseases seen. This increases the ease of training community health workers in the recognition and treatment of common skin diseases. Age, race, and climatic factors are important determinants of skin diseases in adolescents in

  8. Dermatological consequences of the Cs-137 radiological accident in Goiania, Goias State, Brazil; Repercussoes dermatologicas no acidente radioativo com o Cesio 137 em Goiania

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    Castro, Lia Candida Miranda de

    1996-07-01

    The objective of the present study was to analyse the occurrence of dermatosis in individuals that had been exposed to cesium{sup 137} during the radioactive accident in Goiania, in 1987 and detect pre-cancerous dermatosis or those predictive of low immunity. The groups were evaluated according to the intensity of radiation they had been exposed to and then compared to a control group of people not exposed to radiation. The population exposed to the cesium{sup 137} was comprised of 109 people, who were divided into Groups I and II, according to the CNEN norms. In group I, 54 people with {<=} 20 rads exposure and/or radio lesion were included; in group II, 55 people with > 20 rads exposure were included, along with the children of group I individuals. This was a historic cohort study, that is, a retrospective study that lasted 9 years, extending from September of 1987 to August, 1996. The presence of the oncoprotein p-53 was studied in the radio lesions of 10 patients. There is no evidence of an increase in the incidence of dermatosis in the exposed groups, excepts for pyoderma in patients with radio lesions. The most frequent dermatosis were: pyoderma, pityriasis versicolor, scabies, dermatophytosis and seborrhoeic dermatitis. The results obtained were not statistically significant for the evaluation of dermatosis predictive of low immunity or precancerous lesions. The oncoprotein p-53 in individuals with radio lesion showed a 80% positivity rate and risk factor estimated in 8 times, for the test. It has proved to be useful because it represents one more option in terms of propaedeutic evaluation and suggests that one should pay close and continuous attention in order to better control the evolution of these individuals. (author)

  9. Dermatologic Diseases Presenting with Pigmentation Disorders in Children: A Single Center Experience

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    Ayse Akbas

    2015-12-01

    Full Text Available Background: To determine the incidence and demographic characteristics of skin diseases presenting with hyperpigmentation in children applying to the dermatology department. Methods: A total of 2815 children between the ages of 0 to 16 who applied to the dermatology clinic with the complaints of hyperpigmentation disorders were evaluated. The age, gender, socioeconomic status, place of residence and demographic characteristics of children with abnormal pigmentation skin lesions were investigated. Results: A total of 2815 children applied to the dermatology clinic during the study period. Of these patients 1491 were female (53% and 1324 were male (47%. Of these 266 (9.4% were diagnosed with skin disorders presenting with hyperpigmention. The causes of hyperpigmentation in these patients were was follows; pityriasis alba (2.6%, melanocytic nevus (2.1%, vitiligo (1.8% postinflammatory hyperpigmentation (0.5%, and postinflammatory hypopigmentation (0.5%. According to the gender, p.alba, vitiligo, Becker nevus, acanthosis nigricans, tuberosclerosis and albinism were seen more in boys and nevus depigmentosus ephelis, postinflammatory hyperpigmentation/hypopigmentation and melanocytic nevus were seen more in the girls. Pitriyazis versicolor was seen equally in both genders. According to age groups, melanocytis nevus were found to be more frequent between the ages of 0-2 and 12-16, whereas pityrsasis versicolor was more frequent in ages 12-16 and P. alba in the 3-11 age group. Conclusions: There are quite a substantial number of pigmentation diseases occurring in children. Early diagnosis and treatment are important because although these diseases mainly cause cosmetic problems, they can decrease the quality of life. Here, we attempted to define the demographic characteristics of diseases presenting with disorders in pigmentation in children.

  10. Doença de Mucha-Habermann úlceronecrótica febril em adulto com boa resposta à corticoterapia oral Febrile ulceronecrotic Mucha-Habermann disease in adult patient successfully treated with systemic corticosteroid

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    Priscila Wolf Nassif

    2010-12-01

    Full Text Available A doença de Mucha-Habermann ulceronecrótica febril (FUMHD é uma variante clínica rara da pitiríase liquenoide variceliforme aguda (PLEVA. Tem etiologia incerta e é caracterizada por lesões úlceronecróticas, associadas a sintomas sistêmicos. Relata-se um caso de paciente masculino, com início agudo de lesões máculo-papulares, vesicobolhosas e úlceronecróticas, associadas à febre alta e mialgia. Tratado com prednisona 0,5 mg/kg/dia, obteve-se excelente resposta terapêutica. A FUMHD é uma variante severa da PLEVA, cujo diagnóstico é clínico e histopatológico. Vários tratamentos são descritos, tais como: metrotexate, corticoesteroides, PUVA, mas nenhum foi estabelecido.The Febrile Ulceronecrotic Mucha-Habermann (FUMHD disease is a rare variant of pityriasis lichenoides et varioliformis acuta (PLEVA. Its etiology still remains unknown and it is characterized by a sudden onset of ulceronecrotic skin lesions associated with systemic symptons. It is reported here the case of a male patient with a sudden and acute evolution of macules and papules, ulceronecrotic and vesicle-bullous lesions associated with systemic symptons. The patient was treated with prednisone 0,5 mg/kg/day with a dramatic response. The FUMHD is a severe variant of PLEVA and its diagnosis is clinical and histopathological. Many treatments such as methotrexate, corticosteroids and PUVA have been described .However, none of them has been settled.

  11. PREVALENCE OF PAEDIATRIC DERMATOSES IN THE AGE GROUP OF 5-14 YEARS AT A TERTIARY CARE CENTER IN SALEM

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    Prasanna Kanniah Baskara

    2017-01-01

    Full Text Available BACKGROUND Skin diseases in pediatric age group are common all over the world. Pediatric dermatoses require separate view from adult dermatoses as there are differences in their clinical presentation and treatment. OBJECTIVE The aim of our study was to determine the prevalence of pediatric dermatoses attending our tertiary care center. MATERIALS AND METHODS This was a cross-sectional study conducted in 100 consecutive children with dermatoses between 5-14 years of age attending dermatology outpatient department at Vinayaka Missions Kirupananda Variyar medical college, Salem. The study was conducted over a period of 6 months from February 2016 to August 2016. Demographic parameters, detailed history, clinical features and diagnosis were recorded and analyzed. RESULTS In our short term study, we examined 100 pediatric cases with 106 dermatoses. The incidence of infections and infestations (43.39% was more prevalent in our study. The most common non-infectious dermatoses in our study was insect bite reactions (17.9%. Dermatitis and eczema (9.39%, disorders of sweat and sebaceous glands (6.6%, pigmentary disorders (5.66%, disorders of hair and nails (3.77%, genetic disorders (2.88%, immune and allergic disorders (2.8%, psoriasis (2.8%, nutritional disorders (0.9%, Polymorphic light eruption (0.9%, pearly penile papule (0.9%, aphthous ulcer (0.9% and pityriasis rosea (0.9% were the other dermatoses seen in the study.CONCLUSION Fungal infections (tinea versicolor and tinea corporis, scabies and insect bite reactions were the common dermatoses observed in our study. Most of the pediatric patients attending our hospital came from rural areas belonging to low socioeconomic strata. Health education, proper sanitation and improved nutrition will help to reduce the incidence of pediatric dermatoses.

  12. [Mycoses in Venezuela: Working Groups in Mycology reported cases (1984-2010)].

    Science.gov (United States)

    Martínez Méndez, Dilia; Hernández Valles, Rosaura; Alvarado, Primavera; Mendoza, Mireya

    2013-01-03

    In 1984 the Venezuelan Work Groups in Mycology (VWGM) were created introducing an innovative approach to the study of the mycoses in Venezuela. To study the occurrence of the mycoses in Venezuela. Review the reported cases of mycoses by the newsletter Boletín Informativo Las Micosis en Venezuela (VWGM) from 1984 to 2010. The data collected showed 36,968 reported cases of superficial mycoses, 1,989 of deep systemic cases, and 822 of localized mycoses. Pityriasis dermatophytosis was the most common superficial infection, and paracoccidioidomycosis and histoplasmosis the most frequent deep systemic infection. Chromoblastomycosis was the most frequently diagnosed subcutaneous infection. The data provided showed the distribution by geographical area for each of the fungal infections studied, which may help to establish the endemic areas. Superficial mycosis is a public health problem due to its high morbidity and is probably responsible for some of the outbreaks in high-risk groups. Paracoccidioidomycosis and histoplasmosis were reported more often, which agrees with earlier reports prior to the formation of the VWGM. Cases of sporotrichosis and chromoblastomycosis in Venezuela can be considered unique due to the high number of cases. This study highlights the contribution of the VWGM to the behavior of the mycoses in Venezuela, its incidence, prevalence, and the recognition of these infections as a problem of public health importance. The VWGM should keep working in this endeavor, not only reporting new cases, but also unifying the clinical and epidemiological criteria, in order to properly monitor the evolving epidemiological changes reported in these types of infections. Copyright © 2012 Revista Iberoamericana de Micología. Published by Elsevier España, S.L. All rights reserved.

  13. Morbilidad por afecciones dermatológicas: estudio estadístico territorial

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    Rolando Martínez Borrego

    1999-06-01

    Full Text Available Se realizó un estudio retrospectivo de la consulta externa del Hospital Pediátrico Docente Juan Manuel Márquez" en el año 1994 y particularmente de los niños que acudieron a recibir asistencia dermatológica, y se determinó que el 11,4 % (10 645 lo hizo por padecimientos de la piel. Se procesan los datos generales como edad, sexo y áreas de procedencia, así como las afecciones diagnosticadas más frecuentemente. El 30 % correspondió al grupo etáreo comprendido entre 0 a 1 año y casi el 60 % hasta los 5 años de edad. La provincia Ciudad de La Habana y dentro de ella los municipios de Marianao y Lisa aportaron el mayor número de pacientes. El sexo no tuvo diferencias significativas en el trabajo y la escabiosis fue la enfermedad más frecuente en todos los grupos. La dermatitis, piodermitis, verrugas vulgares, moluscum contagioso y Pitiriasis alba, siguieron en orden de frecuencia.A retrospective study of the outpatient department of the "Juan Manuel Márquez" Pediatric Teaching Hospital, and paticularly of those children that received dermatological attention in 1994 was conducted. It was determined that 11.4 % (10 645 went to the hospital due to skin disorders. General data, such as age, sex and areas of origin, as well as the most diagnosed affections were processed. 30 % corresponded to the age group 0-1, and almost 60 % to those aged 5. The province of Havana City, and specially the municipalities of Marianao and La Lisa, had the highest number of patients. No significant differences were observed as regards sex. Scabies was the commonest disease in all groups, followed by dermatitis, pyodermatitis, common warts, molluscum contagiosum and Pityriasis alba.

  14. An epidemiological and clinico-histopathological study of leprosy in semi-urban area under Pimpri Chinchwad Municipal Corporation in Pune district of Maharashtra

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    Alia A Rizvi

    2015-01-01

    Full Text Available Background: Despite having been declared eliminated in December 2005 from India as a public health problem, the prevalence of leprosy exceeds 1/10,000 population in certain districts/states of India. A spurt in its prevalence by 60% - from 0.74 to 1.18 within 1-year from 2012 to 2013 in the area under Pimpri Chinchwad Municipal Corporation (PCMC of Pune district of Maharashtra, wherein our institution is located, motivated us to carry out this study. Aims and Objectives: This prospective study entailed recording of the epidemiological data of cases of leprosy and carrying out correlation of their clinical and histopathological diagnoses as per Ridley–Jopling scale along with inclusion of indeterminate and pure neuritic types. Materials and Methods: Eighty fresh untreated patients hailing from areas under PCMC–in whom leprosy was clinically considered to be either the diagnosis or the differential diagnosis-reporting to the department of dermatology of our tertiary care hospital were enrolled. Their age, sex, and clinical findings were recorded on a proforma. Slit skin and scrape smear were stained by the Ziehl–Neelsen method. Punch biopsies–processed and stained by hematoxylin and eosin and Fite-Faraco method for morphological assessment and identification of the lepra bacilli, respectively–were evaluated histopathologically and a clinico-histopathological correlation, attempted. Results: Male to female ratio of the study patients was 2.3:1; their age ranged from 14 to 74 (mean, 36.67 years. The overall clinico-histopathological concordance observed was 70%. Five cases of indeterminate leprosy (IL emerged on histopathological examination from among the nine skin biopsies on patients of dermatoses mimicking leprosy (pityriasis alba, postinflammatory hypopigmentation, nevus depigmentosus, etc.. Conclusion: This study enabled us to detect additional cases of IL (from among dermatoses mimicking leprosy and led to more accurate typing

  15. CLINICAL SPECTRUM OF PRIMARY SKIN DISORDERS IN CHILDREN LESS THAN 10 YEARS

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    Mridula

    2015-01-01

    Full Text Available BACKGROUND: Skin disorders are a major cause of morbidity in children. Skin diseases can affect the quality of life of children t o a great extent and can hinder their normal growth and development. AIMS: This study was done with the objective of assessing the frequency and clinical spectrum of primary skin disorders in children less than 10 yrs at ESI model hospital, a tertiary care hospital catering to the working community insured under ESI scheme. METHODS: T his was a prospective study of 1 year duration. All children less than 10 yr of age presenting to our hospital were screened for skin disorders. Diagnosis was made clinically in all cases. RESULTS: A total of 282 children were found to have primary skin lesions. The frequency of primary skin disorders was found to be 5.75%. There was male preponderance (54%. Maximum Cases were seen in 0 to 5 yr age group (50%. 63% of cases were seen in children from families with income< 5000 per month. Infections and infestations was the commonest condition seen in 33.94% cases of which 48.6% were pyodermas, 21.6% were fungal infections, 10.8% were viral infections and 18.9 % were scabies. Next commonest condition was atopic dermatitis at 13.76% followed by pityriasis alba at 8.25% and insect bite reaction at 5.8%. CONCLUSIONS : A low frequency of skin disorders was seen in this population group. Males in the age group of less than 5 years had th e maximum incidence. Lower income group had a greater incidence. Infections and infestations were more common than allergic skin conditions

  16. Honey in dermatology and skin care: a review.

    Science.gov (United States)

    Burlando, Bruno; Cornara, Laura

    2013-12-01

    Honey is a bee-derived, supersaturated solution composed mainly of fructose and glucose, and containing proteins and amino acids, vitamins, enzymes, minerals, and other minor components. Historical records of honey skin uses date back to the earliest civilizations, showing that honey has been frequently used as a binder or vehicle, but also for its therapeutic virtues. Antimicrobial properties are pivotal in dermatological applications, owing to enzymatic H2 O2 release or the presence of active components, like methylglyoxal in manuka, while medical-grade honey is also available. Honey is particularly suitable as a dressing for wounds and burns and has also been included in treatments against pityriasis, tinea, seborrhea, dandruff, diaper dermatitis, psoriasis, hemorrhoids, and anal fissure. In cosmetic formulations, it exerts emollient, humectant, soothing, and hair conditioning effects, keeps the skin juvenile and retards wrinkle formation, regulates pH and prevents pathogen infections. Honey-based cosmetic products include lip ointments, cleansing milks, hydrating creams, after sun, tonic lotions, shampoos, and conditioners. The used amounts range between 1 and 10%, but concentrations up to 70% can be reached by mixing with oils, gel, and emulsifiers, or polymer entrapment. Intermediate-moisture, dried, and chemically modified honeys are also used. Mechanisms of action on skin cells are deeply conditioned by the botanical sources and include antioxidant activity, the induction of cytokines and matrix metalloproteinase expression, as well as epithelial-mesenchymal transition in wounded epidermis. Future achievements, throwing light on honey chemistry and pharmacological traits, will open the way to new therapeutic approaches and add considerable market value to the product.

  17. Avaliação da sensibilidade de cepas de Malassezia furfur a imidas cíclicas Sensibility of evaluations of Malassezia furfur strains at cyclic imides

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    Edeltrudes de Oliveira Lima

    2002-12-01

    Full Text Available Malassezia furfur (Pityrosporum orbiculare é um fungo lipofílico, que está associado a pitiríase versicolor, foliculite, dermatite seborréica e atópica, fungemia e infecções sistêmicas. O tratamento é feito com soluções antimicóticas ou derivados imidazólicos, particularmente, o cetoconazol. Dentro das perspectivas de avaliação de novas alternativas para a terapêutica das infecções micóticas, determinou-se, nesse estudo, a atividade antifúngica de compostos imídicos. As imidas 3,4-dicloro-N-fenil-maleimida (6,3 µg/ml, 3,4-dicloro-N-benzil-maleimida (25 µg/ml e 3,4dicloro-N-fenil-propil-maleimida (20 µg/ml foram os compostos que apresentaram melhor atividade inibitória contra as cepas de M. furfur.Malassezia furfur (Pityrosporum orbiculare is a lipophilic microrganism and it has also been associated with pityriasis versicolor, folliculitis, seborrheic and atopic dermatitis, fungemia and systemic infections. The treatment comprehends antimicotics or imidazol derivatives solutions, specially cetoconazol. With purpose of evaluating new alternatives to the therapeutics of mycosis infections, the antifungical activity of cyclic imides was determinated in the present study. The imides 3,4-cichloro-N-phenylmaleimide (6,3 µg/ml, 3,4dichloro-N-benzyl-maleimide (25 µg/mL and 3,4dichloro-N-phenyl-propyl-maleimide (25 µg/mL were the compounds which produced the best activities of inhibition against strains of M. furfur.

  18. 酮康唑乳膏治疗浅部真菌病疗效分析%Efficacy Analysis of Ketoconazole Treat Superficial Mycoses

    Institute of Scientific and Technical Information of China (English)

    钱青; 袁玲玲; 李月花; 翟萍

    2011-01-01

    目的:探讨酮康唑乳膏治疗皮肤浅部真菌病的临床疗效.方法:249例皮肤浅部真菌病患者采用酮康唑乳膏治疗,早晚各1次,连用2~4周,观察临床症状和体征.结果:249例皮肤浅部真菌病患者中,体股癣有效率94.7%;手足癣有效率94.3%;花斑癣有效率97.7%;皮肤念珠菌病有效率95.4%,没有发现不良反应.结论:酮康唑乳膏治疗皮肤浅部真菌病有较高的疗效.%Objective:To discuss clinical efficacy of Ketoconazole cream in the treatment of superficial mycoses.Methods:249 cases of superficial mycoses using ketoconazole cream in the treatment,twice a day, last 2 to 4 weeks,observing clinical symptoms and signs.Results:249 cases of skin in patients with superficial mycoses,efficiency of tinea corporis and cruris is 94.7%;tinea manuum and pedis is 94.3%;pityriasis versicolor isL97.7%;skin candidiasis is 95.4%,no adverse reactions.Conclusion:Ketoconazole cream in the treatment of superficial mycoses have a higher efficacy.

  19. 新型咪唑类抗真菌外用药物卢立康唑%Luliconazole,a novel topical antifungal imidazole

    Institute of Scientific and Technical Information of China (English)

    王玲; 吕雪莲; 刘维达

    2013-01-01

    卢立康唑是一种新型的咪唑类抗真菌外用药物.体内外实验研究及临床研究显示,卢立康唑对皮肤癣菌、白念珠菌、马拉色菌和部分相对少见的暗色及透明丝状真菌均表现出较高的抗真菌活性,对红色毛癣菌的最小抑菌浓度(MIC50)低至0.00024 μg/ml.在日本,1%卢立康唑膏剂和溶液已被批准用于包括皮肤癣菌感染、皮肤念珠菌病和花斑糠疹等浅部真菌感染的治疗.%Luliconazole is a novel,optically active,topically applied antifungal imidazole.In vitro and in vivo experimental studies and clinical studies have revealed that luliconazole has a strong wide-spectrum antifungal activity against Dennatophytes spp.,Candida albicans,Malassezia spp.,and some uncommon pathogens including dematiaceous fungi and hyalohyphomycetes.The 50% minimun inhibitory concentration (MIC50)of luliconazole against Trichophyton rubrum can be as low as 0.00024 μg/ml.In Japan,luliconazole 1% cream/solution has been approved for the treatment of superficial fungal infections including dermatophytosis,cutaneous candidiasis,and pityriasis versicolor.

  20. Assessment of T-cell clonality via T-cell receptor-gamma rearrangements in cutaneous T-cell-dominant infiltrates using polymerase chain reaction and single-stranded DNA conformational polymorphism assay.

    Science.gov (United States)

    Chen, Michael; Deng, April; Crowson, A Neil; Srinivasan, Mythily; Yearsley, Kurtis H; Jewell, Scott; Morrison, Carl; Long, Susan; Werling, Robert; Magro, Cynthia

    2004-12-01

    Discerning the pathologic significance of cutaneous T-cell infiltrates can pose a diagnostic challenge for dermatopathologists. Reactive conditions such as drug-associated lymphomatoid hypersensitivity and lymphomatoid lupus erythematosus can demonstrate lymphoid atypia and a phenotype resembling cutaneous T-cell lymphoma (CTCL). Further, lymphoid dyscrasias such as pityriasis lichenoides chronica, large plaque parapsoriasis, and atypical pigmentary purpura confuse the picture because they not only mimic CTCL but also represent prelymphomatous states with inherent malignant potential. Although the emergence of a dominant clone has been considered a clue indicative of a T-cell dyscrasia, there are reports concerning the identification of monoclonality in biopsies of reactive lymphoid infiltrates. We have conducted a modified single-stranded DNA conformational polymorphism (SSCP) assay using paraffin-embedded, formalin-fixed tissue on 92 T-cell-rich biopsies to determine the relative specificity and sensitivity of this methodology. In addition, laser capture microdissection (LCM) was performed on 22 of the 92 samples to isolate the area of interest and to compare its specificity and sensitivity with those SSCP assays performed without LCM. We found that monoclonality or oligoclonality is 86% specific for preneoplastic and neoplastic states, whereas the finding of polyclonality appears to be relatively specific for a reactive process. Some cases of reversible T-cell dyscrasia produced a molecular profile mimicking lymphoma or prelymphomatous states by virtue of monoclonality or oligoclonality. Although LCM appears to improve the sensitivity for detecting preneoplastic conditions, the relative specificity appears to be the same as that encountered with routine SSCP.

  1. [Superficial mycoses in patients from Anzoátegui state, Venezuela, period 2002-2012].

    Science.gov (United States)

    Lemus-Espinoza, Druvic; Teresa Maniscalchi, María; Villarroel, Oskarina; Bónoli, Stefano B; Wahab, Fadi; García, Oswaldo

    2014-12-01

    Superficial fungal diseases that affect the skin and its appendages are frequently seen in basic triage and in dermatology services. These diseases are distributed in Venezuela with an incidence of 92.9%. The aim of this study was to determine the genera and species that cause dermatomycoses in residents of Anzoátegui state, Venezuela, during the period 2002-2012. A total of 4257 patients with a presumptive diagnosis of superficial mycoses were studied, with ages from 7 months to 79 years. The overall prevalence was 30.9%. The most frequent were dermatophytosis (44.7%). M. canis produced 148 cases of tinea capitis. Three dermatophytic agents represented 95% of all cases, with a significant predominance of T. mentagrophytes with 50%. Candidosis occurred in 28.4%. C. albicans, and the C. parapsilosis complex, were responsible for 80% of the cases. The other species identified were C. tropicalis (n = 41, 11.0%), C. glabrata (n = 10, 2.7%), C. guilliermondii (n = 6, 1.6%), C. krusei (n = 4, 1.1%). Pityriasis versicolor occurred in 22.4% of the cases studied, and less frequently were present onychomycosis produced by a non dermatophytic mold: Fusarium oxysporum (n = 34, 65.4%), Aspergillus terreus (n=16, 30.8%) and Scytalidium dimidiatum (n=2; 3.8%). Rare cases of Trichosporon onychomycosis (0.5%) and one case of black tinea were also found. Health education in the population is recommended to promote measures to prevent transmission of these fungi and prevent the spread of this silent public health problem.

  2. Demodex Mite Density Determinations by Standardized Skin Surface Biopsy and Direct Microscopic Examination and Their Relations with Clinical Types and Distribution Patterns.

    Science.gov (United States)

    Yun, Chul Hyun; Yun, Jeong Hwan; Baek, Jin Ok; Roh, Joo Young; Lee, Jong Rok

    2017-04-01

    Demodicosis is a parasitic skin disease caused by Demodex mites, and the determination of mite density per square centimeter is important to diagnose demodicosis. Standardized skin surface biopsy (SSSB) and direct microscopic examination (DME) are commonly used to determine Demodex mites density (Dd). However, no study has previously compared these two methods with respect to clinical types and distribution patterns of demodicosis. The aim of this study was to compare the value of SSSB and DME findings in reference to the clinical types and distribution patterns of demodicosis. The medical records of 35 patients diagnosed with demodicosis between December 2011 and June 2015 were retrospectively reviewed. Demodicosis was classified according to four clinical types (pityriasis folliculorum, rosacea type, acne type, and perioral type) and three distribution patterns (diffuse pattern, U-zone pattern, and T-zone pattern). Two samples, one for SSSB and one for DME, were obtained from a lesion of each patient. In all patients, mean Dd and the proportion with a high Dd (>5D/cm(2)) by DME (14.5±3.3, 80.0%, respectively) were higher than by SSSB (5.5±1.3, 37.1%, respectively; ptypes, for rosacea type, mean Dd and proportion with a high Dd by DME (12.4±3.5, 84.6%, respectively) were significantly greater than those determined by SSSB (3.6±1.2, 23.1%; p=0.04, p=0.04, respectively). In terms of distribution pattern, for the diffuse pattern, mean Dd and the proportion with a high Dd by DME (17.5±3.7, 100%, respectively) were significantly higher than those determined by SSSB (6.0±2.7, 26.7%; ptype. Further research is needed to confirm this finding.

  3. A New Isolate of the Genus Malassezia Based on the Sequence Analysis of 26S and ITS1 in Ribosomal DNA

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    Hossein Mirhendi

    2009-01-01

    Full Text Available Malassezia species considered to be the etiological agents of pityriasis versicolor andMalassezia follicolitis in humans. Recently, on the basis of molecular data, four new specieswere added to the genus. In total, 11 species have been described and accepted sofar. In this study we describe a new isolate of Malassezia based on the nucleotide sequenceof 26SrDNA and ITS1 regions, as the accepted critical markers for description ofthe species.The yeast was isolated from a hamster. Two primer pairs, one for amplification of D1/D2-26Sr DNA and another for the ITS1 region were used in PCR. The PCR products weresequenced and analyzed to compare with other similar sequences which are already depositedin the GenBank. The 26SrDNA PCR product was also digested with the restrictionenzyme CfoI.Malassezia-specific universal primer pairs successfully amplified the 26srDNA and ITS1regions of the new isolate, providing a single PCR product of about 580 and 280 basepairs, respectively. After digestion of the 26s PCR product with the enzyme CfoI, a uniqueand different RFLP pattern was observed. Sequence analysis of D1/D226s and ITS1 regionswere compared with the same regions in all already described Malassezia species,which implied a different and unique new sequences. The phylogenetic tree of both regionsshowed that the isolate could be a different Malassezia isolate.Regarding the new RFLP pattern of D1/D226SrDBA and the unique nucleotide sequence ofboth D1/D2 26SrDNA and ITS1 regions, we propose the isolate to be a new Malassezia.

  4. Lymphomatoid papulosis type C in a child%儿童淋巴瘤样丘疹病(C型)一例

    Institute of Scientific and Technical Information of China (English)

    惠云; 郑冰洁; 陈浩; 王千秋; 张国毅

    2013-01-01

    A 9-year-old boy was admitted to the hospital for recurrent papules,pustules,crust and necrosis all over the body for 8 years.A diagnosis of lymphomatoid papulosis type C was made according to histopathological and immunohistochemical findings.Lymphomatoid papulosis,as a kind of self-healing primary cutaneous CD30+ lymphoproliferative disorder,can be histopathologically divided into 3 types,i.e.,A,B and C,and little is known about its pathogenesis.Lymphomatoid papulosis is often misdiagnosed as pityriasis lichenoides et varioliformis acuta.Lymphomatoid papulosis type C should be pathologically differentiated from primary cutaneous CD30+ anaplastic large cell lymphoma.%患者男,9岁,因全身丘疹、脓疱、结痂、坏死8年余就诊.皮损组织病理结合免疫组化符合淋巴瘤样丘疹病(C型).淋巴瘤样丘疹病属于原发性皮肤CD30+淋巴增生性疾病,具有自限性,病因研究较少,组织病理学可分为A、B、C三型.临床上易误诊为急性痘疮样苔藓样糠疹,C型组织病理学与原发性皮肤CD30+间变性大细胞性淋巴瘤相似,故鉴别诊断尤为重要.

  5. Cutaneous vasculitides: Clinico-pathological correlation

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    Gupta Suruchi

    2009-01-01

    Full Text Available Background: Cutaneous vasculitis presents as a mosaic of clinical and histological findings. Its pathogenic mechanisms and clinical manifestations are varied. Aims: To study the epidemiological spectrum of cutaneous vasculitides as seen in a dermatologic clinic and to determine the clinico-pathological correlation. Methods: A cohort study was conducted on 50 consecutive patients clinically diagnosed as cutaneous vasculitis in the dermatology outdoor; irrespective of age, sex and duration of the disease. Based on the clinical presentation, vasculitis was classified according to modified Gilliam′s classification. All patients were subjected to a baseline workup consisting of complete hemogram, serum-creatinine levels, serum-urea, liver function tests, chest X-ray, urine (routine and microscopic examination besides antistreptolysin O titer, Mantoux test, cryoglobulin levels, antineutrophilic cytoplasmic antibodies and hepatitis B and C. Histopathological examination was done in all patients while immunofluorescence was done in 23 patients. Results: Out of a total of 50 patients diagnosed clinically as cutaneous vasculitis, 41 were classified as leukocytoclastic vasculitis, 2 as Heinoch−Schonlein purpura, 2 as urticarial vasculitis and one each as nodular vasculitis, polyarteritis nodosa and pityriasis lichenoid et varioliforme acuta. Approximately 50% of the patients had a significant drug history, 10% were attributed to infection and 10% had positive collagen workup without any overt manifestations, while 2% each had Wegener granulomatosis and cryoglobulinemia. No cause was found in 26% cases. Histopathology showed features of vasculitis in 42 patients. Only 23 patients could undergo direct immunofluorescence (DIF, out of which 17 (73.9% were positive for vasculitis. Conclusions: Leukocytoclastic vasculitis was the commonest type of vaculitis presenting to the dermatology outpatient department. The workup of patients with cutaneous vasculitis

  6. [Epidemiological transition of mycosis diseases in sub-Saharan Africa: from surface to depth].

    Science.gov (United States)

    Chandenier, J; Desoubeaux, G

    2015-02-01

    Fungi are schematically responsible for three distinct kinds of infections: superficial mycoses, subcutaneous and deep ones. The current socio-epidemiological transition observed in sub-Saharan Africa does not actually lead to similar consequences regarding these three categories of fungal entities. For instance, it has long been known that superficial mycoses are very prevalent in tropical areas, since they are partly due to the warm climate and the promiscuity. They are mostly caused by dermatophytic fungi or Malassezia sp. (Pityriasis versicolor). Subcutaneous mycoses are rarer, and usually due to dimorphic fungi which are accidentally inoculated into the body after a skin injury or a trauma. Sometimes very spectacular, the clinical outcome is then described as chronic. Thus, chromoblastomycosis, rhinoentomophtoromycosis or mycetoma are some examples of subcutaneous mycoses which remain well-known by practitioners of endemic countries. Deep mycoses (or invasive / systemic mycoses) are defined by fungal infections of deep anatomical sites that should be normally sterile. By contrast with the other entities mentioned above, the outcome may be rapidly fatal for the patient. One of the most outstanding examples was the great increasing of cryptococcal meningitis during the HIV outbreak in the 80'. A few other similar mycoses may be feared in a near future, since they usually occur in contexts of important immunosuppression which are about to be definitely experienced in Africa: overall increase of chronic diseases like diabetes, lengthening life expectancy and its associated diseases, widespread medical practices which were only seen in advanced intensive care units, onco-haematology departments or graft centers so far. Thus, the deep mycoses will inevitably increase in Africa, as they did in all developed countries over the last two decades. The consequences will not only be limited to the clinical management as described above: the diagnostic approach is also

  7. An analysis on misdiagnosis in 14 cases of mycosis fungoides (erythema stage)%红斑期蕈样肉芽肿误诊14例临床病理分析

    Institute of Scientific and Technical Information of China (English)

    布瓦杰尔·亚克亚; 梁俊琴; 邹晓辉

    2015-01-01

    Objective To discuss and analyze 14 patients′clinical characteristics of mycosis fungoides misdi-agnosed in the early stage.Methods Collect and analyze the data of misdiagnosed mycosis fungoides in 14 patients in the Dermatology Department from 2006 to 2014.Results Early phase erythema mycosis granu-loma were easily misdiagnosed as eczema,itchy skin disease,deputy psoriasis,pityriasis rosea or disease of grow in quantity of acidophil,pigment sample skin purpura sample moss,and ringworm of the body etc,with no specificity in the early tissue pathological manifestations.Conclusion In clinical work mycosis fungoides should be given vigilant diagnos to prevent the development of mycosis fungoides to tumor stage.%目的:分析红斑期蕈样肉芽肿患者误诊的临床病理特征,提高对本病的认识,指导临床工作。方法选择2006年1月-2014年10月新疆维吾尔自治区人民医院皮肤性病科诊断为蕈样肉芽肿(红斑期)的患者14例,对其病例资料进行回顾性分析与总结。结果早期红斑期蕈样肉芽肿容易误诊为湿疹、皮肤瘙痒症、副银屑病或玫瑰糠疹、嗜酸细胞增多症、色素性紫癜样苔藓样皮病、体癣等。早期组织病理表现无特异性。结论早期蕈样肉芽肿的临床病理表现多样,临床工作中应提高警惕,尽早明确诊断,防止蕈样肉芽肿发展为肿瘤。

  8. The profile of atopic dermatitis in a tertiary dermatology outpatient clinic in Singapore.

    Science.gov (United States)

    Tay, Y K; Khoo, B P; Goh, C L

    1999-09-01

    Atopic dermatitis is a common, chronic, relapsing, pruritic, eczematous skin condition occurring in patients with a personal or family history of atopy. The aim of this study is to describe the profile of atopic dermatitis seen at a tertiary referral skin center in a tropical multiracial country. A retrospective chart review was conducted of all the patients with atopic dermatitis seen during the first six months of 1994. There were 492 patients, age range from 1 month to 74 years, with an equal sex ratio. The prevalence was 2%. The onset of the disease occurred before the age of 10 years in 61.2% of patients. In 13.6% of patients, the onset was after the age of 21 years. Two hundred and fifty four patients (52%) had "pure" atopic dermatitis without concomitant respiratory allergies; 238 patients (48%) suffered from a "mixed" type, with 23% having allergic rhinitis, 12% having asthma, and 13% having both asthma and allergic rhinitis; 231 patients (47%) had at least one first-degree family member with atopy: atopic dermatitis (17%), asthma (15%), and allergic rhinitis (15%). Most of the patients, 416 (84.5%), had subacute dermatitis at presentation. Ichthyosis vulgaris was present in 38 patients (8%) and pityriasis alba in 13 patients (3%). The most common infective complication was bacterial infection (impetiginized dermatitis, folliculitis, cellulitis) present in 95 patients (19%), followed by viral infections (dermatitis herpeticum, viral warts, and molluscum contagiosum) in 17 patients (3%). Allergies were noted in 43 patients (9%). The most common was drug allergy (penicillin and cotrimoxazole) in 28 patients, followed by food allergy in 11 patients. Common aggravating factors reported included heat, sweating, stress, thick clothing, and grass intolerance. Most patients could be controlled with a fairly simple regimen of moisturizers, topical steroids, and antibiotics for acute flares. Short courses of systemic steroids were used in 78 patients (16%). Three

  9. The epidemiology of atopic dermatitis at a tertiary referral skin center in Singapore.

    Science.gov (United States)

    Tay, Y K; Khoo, B P; Goh, C L

    1999-09-01

    Atopic dermatitis is a common chronic, relapsing, pruritic ecematous skin condition with a predilection for the flexural areas and occurs in patients with a personal or family history of atopy. The aim of this study is to describe the profile of atopic dermatitis seen at the National Skin Centre in Singapore. A retrospective chart review was conducted of all the patients with atopic dermatitis seen during the first six months of 1994. There were 492 patients whose ages ranged from one month to 74 years with an equal sex ratio. The prevalence was 2%. The onset of the disease occurred before the age of 10 years in 61.2% of patients. In 13.6% of the patients, the onset was after the age of 21 years. Two hundred and fifty-four patients (52%) had "pure" atopic dermatitis without concomitant respiratory allergies. Two hundred and thirty-eight patients (48%) suffered from a "mixed" type, with 23% having allergic rhinitis, 12% having asthma and 13% having both asthma and allergic rhinitis. Two hundred and thirty-one patients (47%) had at least one first-degree family member with atropy: atopic dermatitis (17%), asthma (15%) and allergic rhinitis (15%). Most of the patients, 416 (84.5%), had subacute eczema at presentation. Ichthyosis vulgaris was present in 38 patients (8%) and pityriasis alba in 13 patients (3%). The most common infective complication was bacterial infection (impetiginized eczema, folliculitis, cellullitis) present in 95 patients (19%) followed by viral infections (eczema herpeticum, viral warts and molluscum contagiosum) in 17 patients (3%). Allergies were noted in 43 patients (9%) based on the history given. The most common was drug allergies (penicillin and co-trimoxazole) in 28 patients followed by food allergies in 11 patients. Common aggravating factors reported include heat, sweating, stress, thick clothing and grass intolerance. Most patients could be controlled with a fairly simple regimen of moisturizers, topical steroids and antibiotics for

  10. Hanseníase no Município de Buriticupu, Estado do Maranhão: busca ativa de casos na população adulta Leprosy in Buriticupu, State of Maranhão: active search for cases in the adult population

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    Antonio Rafael da Silva

    2010-12-01

    case. The study also identified other skin diseases, including pityriasis versicolor, scabies, mycosis, vitiligo and carcinoma. CONCLUSIONS: The high detection coefficient defines the town of Buriticupu, MA, as hyperendemic for leprosy. Active cases search is an important method for disease control.

  11. Cutaneous Manifestations in Renal Transplant Recipients

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    Fatma Elif Demirgüneş

    2008-05-01

    Full Text Available Background and Design: This study is designed to determine the prevalence and the clinical spectrum of skin diseases in renal transplant recipients (RTRs.Material and Method: In this study RTRs who were referred to our department between 2005 and 2007 for dermatologic examination were evaluated. Dermatologic investigation included direct clinical observation and culture or histolopathological investigation when indicated. Patients were divided into three groups: group A, post-transplantation periods £1 year; group B, post-transplantation periods of 1-5 years; and group C, post-transplantation periods >5 years. Results: In this study 88 (M=50, F=38 RTRs were evaluated. The mean age was 37 ± 12 years and the median interval since transplantation was 38.5 months (range=1 month-27 years. Over a 2-year period 298 cutaneous manifestations were identified. Ninety-five immunosuppressive (IS drug-related manifestations were observed in 58 (%65.9 patients and the most common one was acneiform eruption (n=23. Forty (45.5% patients developed cutaneous viral infections, consisting of verruca vulgaris (n=29, herpes zoster (n=9, herpes simplex (n=5, molluscum (n=2 and varicella (n=1 infections. Superficial fungal infections were observed in 35(39.2% patients, most common lesions were dermatophytosis (n = 23 and pityriasis versicolor (n=17. Bacterial infections were observed in 14 (%16 patients, folliculitis was present in 12 of them. Premalignant and malignant lesions were identified in 12 (%13.6 patients, consisting of actinic keratoses (n=9, basal cell carcinoma (n=2, squamous cell carcinoma (n=1 and Kaposi's sarcoma (n=1. There were more premalignant and malignant lesions in patients receiving azathioprine (p=0.002. Cutaneous viral infections were more common in group C (p=0.023 and IS drug-related manifestations were more common in group A (p=0.003. Conclusion: Most common cutaneous manifestation among RTRs was IS drug-related and seen in early post

  12. Burden of leprosy in Malawi: community camp-based cross-sectional study

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    Msyamboza Kelias P

    2012-08-01

    Full Text Available Abstract Background Although leprosy was eliminated globally in 2000, the disease continues to be the significant cause of peripheral neuropathy, disability and disfigurement in some developing countries. However, recent population-based prevalence data are lacking to inform evidence-based renewed commitment for the final push for leprosy elimination at national and sub-national levels. Methods Community camp-based cross-sectional descriptive study was conducted in four selected districts. World Health Organisation guidelines and tools for leprosy elimination monitoring were used to evaluate the Malawi National Leprosy Programme. Results A total of 6,338 people (60% females, 35% children aged less than 15 years were examined for leprosy and other skin diseases. Prevalence of skin diseases was 18%, the commonest being fungal (9%, eczema/dermatitis (3% and leprosy (1%. Of the fungal skin conditions, pityriasis versicolor and Tinea capatis were the commonest (22% and 21% respectively then Tinea corporis (9%, Tinea cruris (6% and Tinea pedis (2%. A total of 66 leprosy cases were detected out of 6,338 people screened giving a prevalence of 104.1 per 10,000 population (range by district 67.1 to 194.1. Of the leprosy cases, 37 were new, 6 were defaulters and 23 were on treatment, 30 were females and 9 were children aged less than 15 years old. Of the 37 new leprosy cases, 9 (24.3% were children, 25 (67.6% had 1–5 leprosy lesions and 8 (21.6% had grade 2 disability. The most frequent location of leprosy lesions was the head and neck (24.1%, arms (24.1%, chest (17.2%, legs (13.8%, back (13.8% and abdomen (7.0%. Between 2006 and 2011, trends of leprosy prevalence and detection increased, prevalence/detection ratios were over 1 and cure rates by cohort analysis of 2009 multibacillary and 2010 paucibacillary cases were 33% and 63% respectively far below the expected 80% although the national prevalence remained at less than 1 case per 10

  13. Hanseníase no município de Buriticupu, Estado do Maranhão: busca ativa na população estudantil Leprosy in the municipality of Buriticupu, State of Maranhão: active search among the student population

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    Antonio Rafael da Silva

    2007-12-01

    hyperkeratosis, mononuclear inflammatory infiltrate and ectasia of vessels and isolated arrector pili muscles. The study also enabled identification of some other infectious skin diseases: pityriasis versicolor in 793, scabies in 361 and dermatophytosis in 119. A variety of nonspecific conditions were also detected, such as scars, nevi and excoriation, in 1,020 students.

  14. Diseases associated with hidranitis suppurativa: part 2 of a series on hidradenitis.

    Science.gov (United States)

    Scheinfeld, Noah

    2013-06-15

    diseases is likely underreported. Pyoderma vegetans has been noted in 2 cases of HS and 4 cases of Inflammatory Bowel Disease (IBD) and is likely a clue to the linkage of the pathology of IBD and HS. Pityriasis rubra pilaris, in particular Type VI related to HIV, has a relationship more commonly with acne conglobata, but with HS also. Single case reports of diseases associated with HS include systemic lupus erythematosus, acromegaly, Down syndrome, Bazex-Dupre´-Christol, and prurtis ani, but these might be coincidences. Pyogenic Arthritis, Pyoderma gangrenosum, and Acne (PAPA Syndrome) and Pyoderma gangrenosum, Acne, and Suppurative Hidradenitis (PASH Syndrome) are pyodermic-arthritic syndromes that are associated with HS. Erythema nodosum and granulomatous lobular mastitis have been reported with HS but the significance of these reports is uncertain. Because of scarring, HS can result in lymphedema including scrotal elephantiasis and verrucous lymphedema. HS is sometimes accompanied by obesity, hypertension, and anemia and can be considered a disease in the spectrum of metabolic syndrome, a skin disease with systemic consequences. HS, like other types of chronic inflammation when long standing in the perianal and perineal areas, can result in squamous cell cancer. A variety of drugs can induce HS. These include lithium, sirolimus, cyclosporine, vemurafenib, and oral contraceptives. Inverse psoriasis or psoriasis vulgaris as a side effect of infliximab therapy may be associated with HS. These associations aside, most cases of HS occur in isolation without coincident morbidity.

  15. Dermatite esfoliativa: estudo clínico-etiológico de 58 casos Exfoliative dermatitis: clinical and etiologic study of 58 cases

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    Rogério Nabor Kondo

    2006-06-01

    exfoliative dermatitis seen at the Hospital Universitário Regional do Norte do Paraná were reviewed over a ten-year period. RESULTS - A total of 58 patients with diagnosis of exfoliative dermatitis was assessed. Mean age was 56.89 years. The underlying disorder in 33 patients was a skin disease (psoriasis, 11 cases; contact dermatitis, 9 cases; congenital ichthyosiform erythroderma, 3 cases; seborrheic dermatitis, 5 cases; atopic dermatitis, 3 cases; pityriasis rubra pilaris, 2 cases. Drug reactions were observed in 11 patients. Etiology could not be determined in 14 cases (24%. CONCLUSIONS - In a sample of patients attending a reference dermatology center, exfoliative dermatitis was a rare condition, and in most cases it was related to skin diseases.

  16. Study of dermatoses in kidney transplant patients Estudo das dermatoses em pacientes transplantados renais

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    Alexandre Moretti de Lima

    2013-06-01

    Full Text Available BACKGROUND: The increasing in the number of kidney transplant recipients has favored, more frequently than before, the emergence of dermatoses and warranted their study through subsequent publications. OBJECTIVES: to evaluate the frequency of dermatoses in kidney transplant recipients. METHODS: kidney transplant recipients with suspected dermatoses between March 1st 2009 and June 30th 2010. RESULTS: 53 patients (28 males and 25 females, aged between 22 and 69 (mean age = 45 years were evaluated. Most of them came from the cities of Ceilândia, Samambaia and São Sebastião/DF, and had already been transplanted for 5 to 10 years before (37.7%; 62.3% were recipients of living donors and 83% were prednisone-treated. The most prevalent dermatoses were of fungal (45.3% and viral (39.6% etiologies. Among the non-melanoma malignant neoplasms, the basal cell carcinoma prevailed (six cases, in spite of the low incidence. Concerning fungal dermatoses, 12 cases of onychomycosis, five of pityriasis versicolor and four of pityrosporum folliculitis were reported. For diagnosis, in most cases (64.2%, laboratory examinations (mycological and histopathological were performed. CONCLUSION: cutaneous manifestations in kidney transplant recipients are generally secondary to immunosuppression. The infectious dermatoses, especially those of fungal origin, are frequently found in kidney transplant recipients and their occurrence increases progressively according to the time elapsed from the transplantation, which makes follow-up important. FUNDAMENTOS: o crescente aumento do número dos transplantados renais tem favorecido o aparecimento mais frequente das dermatoses e permitido o estudo em sucessivos trabalhos. OBJETIVOS: avaliar a frequência das dermatoses em pacientes transplantados renais. MÉTODOS: captação de pacientes transplantados renais durante o período de 1° de março de 2009 a 30 de junho de 2010 com suspeita de dermatoses. RESULTADOS : foram

  17. Aspectos clínicos da epidermodisplasia verruciforme Clinical aspects of epidermodysplasia verruciformis

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    Walmar Roncalli Pereira de Oliveira

    2002-10-01

    3 years. The clinical diagnosis was confirmed by histopathological and immunohistochemical findings. RESULTS: The EV began in childhood with flat warts and/or erithematous macules on the face and neck. The parental consanguinity was observed in most patients (12/13. Clinically the lesions were highly polymorphic with flat wart-like lesions, pityriasis versicolor-like lesions, erithematous macules and seborrheic keratoses-like lesions. The malignant conversion of lesions occured in 8 patients (62%. The tumor growth provoked heavy tissue loss in 50% of patients, and metastatic tumors caused death in 25%. CONCLUSION: The EV presents high familial incidence and an autosomal recessive mode of inheritance. The high polymorphism clinical doesn't affect the scalp and mucous membrane. The most frequent clinical manifestation is the "malignant" (62%, followed by "benignant" (23% and "mixed"(15%. The cutaneous tumors are frequent, multiple, destructive, metastasize and cause death.

  18. Analysis of 1646 Cases of Children Superficial Mycosis in Kunming Region%昆明地区儿童浅部真菌病1646例分析

    Institute of Scientific and Technical Information of China (English)

    黄云丽; 张道军; 李红宾; 公丽红; 明迪; 张卫卫

    2012-01-01

    Objective To investigate the prevalence and pathogenic fungi species of dermatomycoses in children in Kunming region. Methods The specimens from patients (aged ≤14 years old) suspected of having dermatomycoses were examined microscopically in KOH preparations and cultured on Sabouraud dextrose agar (SDA). Results Among 2176 suspected cases, 1477 cases (67. 88% ) had positive result, 1226 strains (56, 34% ) pathogenic fungi were isolated- The diseases were consisted of tinea capitis(38, 88% ) , tinea corporis(28. 68% ) , tinea pedis( 11, 0% ) , pityriasis versicolor(6, 26% ) ,onychomycosis(5. 95% ) , tinea manus(3. 04% ) , tinea cruris(2. 49% ) , cutaneous candidiasis(2. 43% ) .malassezia folliculitis( L 28% ). The top three of the isolated pathogenic fungi are Microsporum canis (26- 26% ) , Grubyella ferruginea (26. 26% ) and Trichophyton rubrum (18. 11% ), Conclusion In Kunming district,tinea capitis is of the hightest prevalence in children, and Microsporum canis, Grubyella ferruginea and Trichophyton rubrum is the common pathogenic fungi.%目的 了解昆明地区儿童浅部真菌病的流行及病原菌的分布特点.方法 对该科门诊拟诊为浅部真菌病患儿(年龄≤14岁)行真菌镜检、培养及分离鉴定.结果 2176例拟诊为浅部真菌病患儿中,真菌直接镜检阳性1477例,阳性率67.88%,培养分离出真菌1226株,阳性率56.34%.镜检阳性和(或)培养阳性的1646例标本中,头癣、体癣、足癣发病例数居前3位,分别为640例(38.88%)、472例(28.68%)和181例(11.00%),余依次为花斑癣103例(6.26%)、甲真菌病98例(5.95%)、手癣50例(3.04%)、股癣41例(2.49%)、皮肤念珠菌病40例(2.43%)、马拉色菌毛囊炎21例(1.28%).分离的1226株致病菌株中前3位是犬小孢子菌(26.26%)、铁锈色小孢子菌(26.26%)和红色毛癣菌(18.11%).结论 昆明地区儿童浅部真菌病中头癣居首位,致病菌以犬小孢子菌、铁锈色小孢子菌、红色毛癣菌为主.

  19. 偏振光皮肤镜在白癜风早期诊断及与其他色素减退斑鉴别中的应用%Application of polarized light dermoescopy in the early diagnosis of vitiligo and its differential diagnosis from other depigmented diseases

    Institute of Scientific and Technical Information of China (English)

    孟如松; 赵广; 蔡瑞康; 孟晓; 姜志国

    2009-01-01

    Objective To investigate the early diagnosis of vitiligo and its differential diagnosis from other depigmentated diseases using polarized light dermoscopy(PD)imaging analysis.Methods Patients with localized depigmented macules were enrolled into this study.PD was used to observe the micromorphology,feature and color of skin lesions.Histopathology was performed to confirm the diagnosis of all cases except for those of pityriasis versicolor which were confirmed by clinical and laboratory examination.Results Of the 176 patients.97 were diagnosed as vitiligo.Residual perifollicular pigmentation Was observed in 91.94%(57/62)of patients with progressing vitiligo and 62.86%(22/35)of those with stable vitiligo,with significant difference between the two groups of patients(P<0.05).However.residual perifollicular pigmentation was absent in the 79 non-vitiligo depigrnented cases.The presence of telangiectasia,early reservoirs of pigmentation and perilesional hyperpigmentation were related to the stage of vitiligo and treatment history of patients.Conclusions PD,which efficiently eliminates the interference of reflected light on skin lesions of vililigo,is an imaging technique that allows for the visualization of minor structures and features of the skin lesions that are indiscernible to naked eyes.In a nutshell,the application of PD has offered references to the early diagnosis of vitiligo and its differential diagnosis from other depigmentation diseases.%目的 探讨偏振光皮肤镜图像分析技术在白癜风早期诊断中的应用及与其他色素减退斑的鉴别.方法 收集局限性色素减退斑患者,采用偏振光皮肤镜观察皮损微观形态、特征和颜色;所选病例除花斑糠疹经临床与实验室检查确诊外,其余病例均经病理活检确诊.结果 176例患者中,白癜风97例,进展期毛周色素残留发生率达91.94%,显著高于稳定期(62.86%),两者之间差异有统计学意义(P<0.05);毛细血管扩张、早期色素岛

  20. A field investigation into the type and pathogen of superficial fungal infection at different countryside areas in Jiangxi Province,China%江西省农村地区浅部真菌病现场调查及致病菌的研究

    Institute of Scientific and Technical Information of China (English)

    邵丹; 喻玉华; 杨惠玲; 杨春华; 周柳华; 江情; 刘微娜; 罗来华; 万梅香; 刘琰; 丁世伟; 耿承芳; 刘红光; 占萍; 李智华; 薛玮; 王小兵; 陈琼霞; 徐标; 叶发舜; 罗宝香

    2008-01-01

    目的 了解江西省农村地区居民浅部真菌病构成情况及致病菌的种类.方法 2006年9月至2007年6月对江西省的11个地市、54个县区的66个乡(镇)、村居民以义诊的形式进行浅部真菌病现场调查,同时对513例具有典型临床表现且真菌镜检阳性的皮损进行真菌培养.结果 共调查浅部真菌病患者1284例,其中务农者947例,占73.75%.浅部真菌病包括足癣736例(57.32%)、手癣202例(15.73%)、甲真菌病72例(5.61%)、体癣47例(3.66%)、股癣29例(2.26%)、花斑癣23例(1.79%)、头癣1例、皮肤念珠菌病1例、手足癣135例(10.51%)、手癣合并指甲真菌病12例、足癣合并趾甲真菌病10例、手足癣合并指趾甲真菌病8例、体股癣3例、手癣合并体癣2例,以及手足癣合并体癣、足癣合并花斑癣、足癣合并体癣各1例.分离出致病真菌480株,其中红色毛癣菌301株、白念珠菌88株、须毛癣菌41株、其他菌50株.结论 浅部真菌病的致病菌以红色毛癣菌占优势,白念珠菌第二,各地市之间菌种分布构成差异无统计学意义.%Objective To profile the type and pathogen of superficial fungal inactions at rural areas of Jiangxi province in China.Methods A field investigation was conducted via benefit diagnosis in 66 towns,54 counties of 11 regions in Jiangxi province,China,from September 2006 to June 2007.Questionnaire was designed to collect demography and clinical data from local inhabitants.Additionally,when the lesion was positive for fungus on microscopic examination,fungal culture was performed.Results A total of 1,284 patients were recruited,and 73.75%(947)were peasants.Fungal culture was performed in specimens from 513 patients.Among the 1,284 cases,tinea pedis accouted for 57.32%(736),followed by tinea manum(15.73%),onychomycosis(5.61%),tinea corporis(3.66%),tinea cruris(2.26%),pityriasis versicolor(1.79%),tinea capitis(0.08%),cutaneous candidiasis (0.08%).and multiple-site fungal

  1. 北京儿童医院2008年皮肤病初诊病例统计分析%Analysis of dermatological outpatients first visit to Beijing children's hospital in 2008

    Institute of Scientific and Technical Information of China (English)

    向欣; 申春平; 徐子刚; 王建才; 马琳

    2011-01-01

    Objective: To determine the constitution of skin diseases of the patients first visit to Beijing Children’s Hospital, so as to develop appropriate treatment, prevention and management measures for the skin diseases.Methods: The basic information of these outpatients from February 16,2008 to February 15,2009 was collected.SPSS12.0 software was used to analyze the data.Results: The number of total patients was 104 278 cases,among them: eczema 34 687 cases (32.0%), papular urticaria 12 791 cases(11.8%), urticaria 7 798 cases (7.2%), frictional lichenoid eruption 4 490 cases (4.1%), vascular tumors 3 540 cases (3.3%), viral examthema 3 152 cases (2.9%), pityriasis alba 2 706 cases (2.5%), molluscum contagiosum 2 015 cases (1.9%), pompholyx 1 663 cases (1.5%), acne 1 492 cases (1.4%).Age distribution: 858 cases were neonates (0.8%), infants (<1 year) 28 512 cases (27.3%), infants (1-3 year) 28 396 cases (27.2%), pre-school children 21 396 cases(20.5%), school-age children 21 603 cases (20.7%), adolescent 3 513 cases (3.4%).Monthly distribution: January 6 703 cases (6.4%), February 8 955 cases (8.6%), March 8 475 cases (8.1%), April 9 124 cases (8.7%), May 10 291 cases (9.9%), June 9 272 cases(8.9%), July 10 793 cases (10.4%), August 9 982 cases (9.6%), September 7 877 cases (7.6%), October 8 880 cases (8.5%), November 7 373 cases (7.1%), December 6 553 cases (6.3%).Conclusion: Allergic dermatoses, including eczema,papular urticaria and urticaria, are the key diseases for treatment, prevention and management in children.Infants (<3 year) are the key age for the treatment, prevention and management in children.May and October are the key time for the treatment,prevention and management in children.%目的:通过对北京儿童医院皮肤科门诊初诊患儿的统计分析,了解该院儿童皮肤病的构成,以制定相应的诊疗、防控和管理措施.方法:统计于2008年2月16