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Sample records for pityriasis rubra pilaris

  1. [Pityriasis rubra pilaris].

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    Wollina, U

    2012-08-01

    Pityriasis rubra pilaris is an inflammatory papulosquamous skin disease of unknown etiology. Incidence rates vary between 1:5,000-1:50,000. Six subtypes are differentiated on clinical background. The juvenile circumscribed subtype has best prognosis. Generalized disease impairs quality of life of patients. It is associated with various complications and comorbidities. Treatment of pityriasis rubra pilaris is challenging. Retinoids are first line drugs. In recalcitrant cases, tumor necrosis factor-α inhibitors have been used successfully.

  2. Adult onset pityriasis rubra pilaris

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    Sehgal Virendra

    2008-01-01

    Full Text Available Pityriasis rubra pilaris (PRP has always been an intriguing topic ever since its inception. It is a group of chronic disorders characterized by reddish orange plaques with pityriasiform scaling showing follicular keratoses, palmoplantar keratoderma, and sometimes, erythroderma. It occurs all over the world but with racial variations. Its incidence might vary and the age at onset, behavior, clinical appearance, and prognosis are considered to be very important for its classification. It may manifest either as Type I classical adult onset PRP, Type II atypical adult (onset PRP, or Type VI PRP (HIV-associated PRP pityriasis rubra pilaris in contrast to classical juvenile (Type III and circumscribed juvenile (Type IV encountered among children. Its diagnosis is largely clinical with microscopic pathology being a useful supplement, but it continues to be a therapeutic dilemma. We review the epidemiology of adult onset PRP here and take stock of the prevalent treatment options.

  3. Pityriasis rubra pilaris following exposure to dolomite.

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    Iraji, Fariba; Siadat, Amir H

    2013-07-01

    In this case report, we present a 30-year-old man who developed pityriasis rubra pilaris (PRP) following exposure to Dolomite. The diagnosis of PRP was confirmed histologically and the patient was successfully treated with acitretin and cyclosporine.

  4. Pityriasis rubra pilaris (Devergie's disease: clinical case

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    Galkina ЕМ

    2016-09-01

    Full Text Available Pityriasis rubra pilaris (Devergie's disease is a rare chronic papulosquamous skin disease, it is of unknown etiology, leading to palmoplantar keratoderma, erythroderma and ectropion. Due to its rarity and difficulty in differentiating it with psoriasis, we are presenting our own observations and diagnostcis. We present a patient with a classical type 1 iasis rubra pilaris of a type I, whose condition improved significantly after treatment with systemic aromatic retinoids.

  5. Diagnosis and Treatment of Pityriasis Rubra Pilaris

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    Kubanov Alexey

    2014-12-01

    Full Text Available The article deals with clinical diagnosis and treatment of pityriasis rubra pilaris (PRP. The authors analyze the diagnostic errors, present literature review, and their own observations. The clinical study included 23 patients with pityriasis rubra pilaris: 18 women and 5 men, average age of 54 ± 7.2. The clinical diagnosis of all examined patients was subsequently confirmed by histological analysis of the skin. The primary clinical diagnosis was psoriasis in 15 (65.2% patients, 6 (26% patients received treatment for toxic exanthema, and only 2 (8.8% patients were presumptively diagnosed with pityriasis rubra pilaris. In conclusion, pityriasis rubra pilaris was initially misdiagnosed in 91.2% of patients. Considering the great number of diagnostic errors, we analyzed the main diagnostic and differential diagnostic features of PRP. The most effective of all synthetic retinoids in PRP treatment is acitretin. Although symptomatic improvement in PRP occurs within a month, substantial improvement, even clearing is possible within 4 - 6 months.

  6. Surgical Management of Cicatricial Ectropion in Pityriasis Rubra Pilaris.

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    Haridas, Anjana S; Sullivan, Timothy J

    2016-01-01

    Pityriasis rubra pilaris is an idiopathic, papulosquamous dermatological disease. It is clinically and histologically distinct from, but may resemble, psoriasis. Pityriasis rubra pilaris can be self-limiting but may also run a protracted, relapsing course. Medical treatment may involve topical emollients, systemic retinoids, methotrexate, and/or tumor necrosis factor antagonists. Ocular complications include cicatricial ectropion. The authors describe the surgical management of 3 patients with cicatricial ectropion secondary to pityriasis rubra pilaris. All patients had procedures involving skin grafts; 1 patient required multiple operations. The management principles are discussed, including the role and timing of surgery, within the context of emerging treatments for pityriasis rubra pilaris. Patients with pityriasis rubra pilaris and cicatricial ectropion should be closely managed by both ophthalmologist and dermatologist. The eyelid position may improve with conservative or surgical measures. If surgery is required, the limitations of skin grafting under these circumstances should be anticipated and patients counseled appropriately.

  7. Bevacizumab-induced pityriasis rubra pilaris-like eruption

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    Brown, Shannon; Fletcher, J. Wesley; Fiala, Katherine H.

    2016-01-01

    Pityriasis rubra pilaris is a rare inflammatory disorder characterized by follicular papules on an erythematous base often exhibiting islands of unaffected skin, follicular plugging, and palmoplantar hyperkeratosis. While vitamin A deficiency and autoimmune reactions have been hypothesized as possible etiologies of this condition, pityriasis rubra pilaris-like eruptions secondary to medications are extremely rare. To our knowledge, only three other cases have been reported, and pityriasis rub...

  8. Juvenil Pityriasis Rubra Pilaris: A Case Report

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    M. Emin YANIK et al.

    2010-05-01

    Full Text Available Juvenile pityriasis rubra pilaris (PRP is an uncommon skin disease characterized by follicularkeratotic papules, erythemato-squamous plaques and palmoplantar keratoderma. Etyology isunknown. A 8 years-old boy presented with a 15 days history of scaly patches and plaques withfollicular papules involving his scalp and face. However he had palmoplantar keratoderma onhis hands and feet. Based upon clinical and histopatological findings, he was diagnosed asJuvenile PRP. Acitretin was initiated for therapy. We presented our case because of its rarity.

  9. Systemic sclerosis in a patient with pityriasis rubra pilaris.

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    Frikha, Faten; Frigui, Makram; Masmoudi, Hatem; Turki, Hamida; Bahloul, Zouhir

    2010-08-09

    Pityriasis rubra pilaris (PRP) is a rare, chronic erythematous squamous disorder of unknown etiology. It has been found in association with several autoimmune diseases, including thyroiditis, myositis, myasthenia gravis and vitiligo. Herein we report a case of systemic sclerosis in a patient with classic adult pityriasis rubra pilaris. A 38 year old woman with classic adult type 1 pityriasis rubra pilaris (PRP) developed progressive skin thickening of the trunk, face, upper and lower extremities after 2 years of PRP treatment with topical emollients and steroids. Clinical examination and immunological findings were consistent with SSc. Co-existence of these two rare conditions is documented for the first time.

  10. Systemic sclerosis in a patient with pityriasis rubra pilaris

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    Hamida Turki

    2010-08-01

    Full Text Available Pityriasis rubra pilaris (PRP is a rare, chronic erythematous squamous disorder of unknown etiology. It has been found in association with several autoimmune diseases, including thyroiditis, myositis, myasthenia gravis and vitiligo. Herein we report a case of systemic sclerosis in a patient with classic adult pityriasis rubra pilaris. A 38 year old woman with classic adult type 1 pityriasis rubra pilaris (PRP developed progressive skin thickening of the trunk, face, upper and lower extremities after 2 years of PRP treatment with topical emollients and steroids. Clinical examination and immunological findings were consistent with SSc. Co-existence of these two rare conditions is documented for the first time

  11. Pityriasis Rubra Pilaris In The Indian Scenario

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    Sarkar Rashmi

    2002-01-01

    Full Text Available Pityriasis rubra pilaris (PRP is an uncommon idiopathic papulosqamous disorder characterized by circumscribed follicular keratosis, palmoplantar keratoderma and frequently erythroderma. Seven patients of PRP (five females and two males in the age range of 2 to 50 years seen over a 2-year period are presented with their clinical features, triggering factors, associations and laboratory investigations. The clinical type of PRP was adult onset classical variety in three, juvenile circumscribed variety in two and adult onset atypical variety and juvenile classical variety in one each. The triggering factors were upper respiratory tract infection with nutritional deficiencies in two and folliculitis in one. The histopathology was consistent with PRP in all. Four patients were managed with oral vitamin A while one each was put on methotrexate, etretinate and topical steroids and they showed a good response. More number of cases should be studied over a longer period to substantiate the suggested immunologic mechanism of PRP.

  12. Oral Alitretinoin for the Treatment of Recalcitrant Pityriasis Rubra Pilaris

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    Laurenz Schmitt

    2011-04-01

    Full Text Available Treatment of pityriasis rubra pilaris is still challenging. We here present a 74-year-old woman who had not experienced stable remission of her skin symptoms during prior treatments including topical and systemic corticosteroids, phototherapy, orally administered acitretin, cyclosporine, methotrexate and adalimumab. A therapy with oral alitretinoin was started and tolerated very well. After a few weeks, skin condition improved significantly and itching and scaling disappeared. The present case shows that alitretinoin might be an alternative in the treatment of recalcitrant pityriasis rubra pilaris type I. Further studies are needed to investigate the benefit of this encouraging result.

  13. Successful treatment of pityriasis rubra pilaris with adalimumab - case report.

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    Bravo, Erick A; Carrion, Leonidas; Paucar, Silvia M; Mendoza, Rossana; Rivera, Carlos

    2014-04-16

    Pityriasis Rubra Pilaris (PRP) is an uncommon skin disorder characterized by follicular keratosis, palmoplantar keratoderma, and erythroderma. The traditional preferred treatment is oral retinoids, but over the last decade, biologic therapy with anti-TNF agents has been used with success. We report the case of a 51 year- old man with a clinical and histopathological diagnosis of PRP. He underwent therapy with adalimumab and showed clearance of skin lesions within the fourth week of treatment.

  14. Pityriasis rubra pilaris: treatment with biologics - a new promising therapy?

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    Ivanova, Katja; Itin, Peter; Haeusermann, Peter

    2012-01-01

    Pityriasis rubra pilaris (PRP) includes a spectrum of rare chronic inflammatory disorders with papulosquamous eruptions of unknown cause. Different etiologies have been proposed such as vitamin A metabolism dysfunction, association with autoimmune disorders, infection or malignancies. However, PRP seems to be a polygenic skin disorder. Classical systemic treatment is empirical and includes retinoids and methotrexate; however, only few series on treatments exist. Recently there has been an increasing number of reports documenting that new biologicals and in particular TNF-α blockers are safe and effective. Copyright © 2012 S. Karger AG, Basel.

  15. Pityriasis Rubra Pilaris in a 3-Year-Old Male.

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    Stacey, Stephen K; Novek, Steven J; Maddox, Craig L

    2016-03-01

    A 3-year-old male presented with progressive pruritic red-orange plaques across most of his body with erythema, desquamation, and fissuring of the hands and feet. He was diagnosed with classic juvenile (type III) pityriasis rubra pilaris (PRP) and treated with oral isotretinoin for 6 months. His skin findings resolved quickly during the treatment period, with residual postinflammatory hypopigmentation resolving within a year. PRP is rare in pediatric patients and standard recommended treatment algorithms for this population are not currently available. Diagnostic and treatment guidelines for PRP are based almost exclusively on case reports or case series, most of which focus on adult patients. The presentation, evaluation, and management of PRP are discussed. Reprint & Copyright © 2016 Association of Military Surgeons of the U.S.

  16. Drug-related pityriasis rubra pilaris with acantholysis.

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    Gajinov, Zorica T; Matić, Milan B; Duran, Verica D; Vucković, Nada; Prcić, Sonja T; Vujanović, Ljuba M

    2013-09-01

    Acantholysis is rarely reported histological feature of Pityriasis rubra pilaris (PRP), recently recognized as having diagnostic specificity for differentiating PRP from psoriasis. Adult male patient one week after the introduction of simvastatin had experienced pruritic erythemo-squamous eruption on head and upper trunk that in a month progressed to erythrodermia, with islands of sparing. Histological picture combined pemphigus-like acantholysis with alternating hyper- and parakeratosis, follicular plugs and dermal inflammation, and confirmed the clinical diagnosis of classic adult type 1 PRP. Acitretin therapy resulted in a resolution of skin disease. Patch test with simvastatin was negative, scratch test was positive, and it was estimated that potential risk of oral challenge with simvastatin outweighed actual need for it. Drug triggering PRP episode is the most likely explanation for temporal relation between the start of simvastatin treatment and skin eruption. In management of rare inflammatory skin disease, such as PRP, we have to carefully observe and evaluate not only diagnostic features but possible external influences on its course also.

  17. Drug-related pityriasis rubra pilaris with acantholysis

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    Gajinov Zorica T.

    2013-01-01

    Full Text Available Introduction. Acantholysis is rarely reported histological feature of Pityriasis rubra pilaris (PRP, recently recognized as having diagnostic specificity for differentiating PRP from psoriasis. Case report. Adult male patient one week after the introduction of simvastatin had experienced pruritic erythemo-squamous eruption on head and upper trunk that in a month progressed to erythrodermia, with islands of sparing. Histological picture combined pemphigus-like acantholysis with alternating hyper- and parakeratosis, follicular plugs and dermal inflammation, and confirmed the clinical diagnosis of classic adult type 1 PRP. Acitretin therapy resulted in a resolution of skin disease. Patch test with simvastatin was negative, scratch test was positive, and it was estimated that potential risk of oral challenge with simvastatin outweighed actual need for it. Drug triggering PRP episode is the most likely explanation for temporal relation between the start of simvastatin treatment and skin eruption. Conclusion. In management of rare inflammatory skin disease, such as PRP, we have to carefully observe and evaluate not only diagnostic features but possible external influences on its course also.

  18. Differentiation of pityriasis rubra pilaris from plaque psoriasis by dermoscopy.

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    Abdel-Azim, N E; Ismail, S A; Fathy, E

    2017-05-01

    Pityriasis rubra pilaris (PRP) and plaque psoriasis (PP) are two distinctive erythemato-squamous skin diseases that often have to be differentiated from each other and from other similar dermatoses. Dermoscopy has been proven to aid the clinical diagnosis of several inflammatory disorders, minimizing the need for skin biopsy. Our aim was to determine the dermoscopic patterns of PRP compared to PP and to assess the significance of certain dermoscopic criteria in the diagnosis of PRP. This case-control study included 11 patients with biopsy proven PRP and 25 patients with biopsy proven plaque psoriasis. The most recently developed lesion of each patient was examined by non-contact dermoscopy. Whitish keratotic plugs and linear vessels in yellowish background are significant dermoscopic features of PRP compared to white diffuse scales and dotted vessels in a light red background in PP. In conclusion, PRP and PP reveal specific distinguishing dermoscopic patterns that may assist in their clinical diagnosis and may also be useful for the differential diagnosis from other resembling dermatoses.

  19. An unusual cluster of circumscribed juvenile pityriasis rubra pilaris cases.

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    Martin, Kari L; Holland, Kristen E; Lyon, Valerie; Chiu, Yvonne E

    2014-01-01

    Circumscribed juvenile pityriasis rubra pilaris (PRP) is an uncommon dermatosis. We describe the unusual clustering of circumscribed juvenile PRP cases in our pediatric dermatology clinic in 2011. A retrospective chart review was done of patients presenting during the summer of 2011 with classic findings of circumscribed juvenile PRP. Clinical data including past medical and family history, presenting symptoms, infectious disease history and evaluation, biopsy results, and management were recorded. Seven patients, ages 5 to 19 years, all had strikingly similar skin findings of pink to hyperpigmented, well-defined, scaly papules and plaques on their elbows, knees, dorsal hands, ankles, and Achilles tendons. Four of the seven also had palmoplantar involvement. Four were sibling pairs and the other three were unrelated. Streptococcus pyogenes infection was suspected as a trigger in four of the patients. The unusual clustering of this uncommon disease, along with the occurrence in two sibling pairs, suggests that a genetic susceptibility unmasked by an infectious agent may play a role in its pathogenesis. © 2014 Wiley Periodicals, Inc.

  20. Pityriasis rubra pilaris: a review of diagnosis and treatment.

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    Klein, Annette; Landthaler, Michael; Karrer, Sigrid

    2010-01-01

    Pityriasis rubra pilaris (PRP) is a rare inflammatory dermatosis of unknown etiology, and finding a successful therapy can be challenging. PRP occurs equally in men and women. In some patients, associated autoimmune diseases, infections, or malignancies are possible trigger factors. PRP shows a bimodal age distribution, peaking in the first as well as in the fifth to sixth decade. Its classification into five subgroups is based on age at onset, clinical course, morphologic features, and prognosis. More than 50% of patients are best classified as type I with adult-onset PRP. This form is also characterized by high spontaneous remission rates (80%) within 1-3 years. Clinically, the classical adult (type I) and classical juvenile (type III) forms appear to be the same except for the patient's age. Recently, the designation of a new category of PRP (type VI) has been proposed that is characterized by the presence of HIV infection with different clinical features and a poorer prognosis. Typical morphologic features of PRP are erythematosquamous salmon-colored plaques with well demarcated islands of unaffected skin. Often, keratoderma of the palms and soles is present. In patients with extensive disease, ectropion is a dreaded complication. Histology shows hyperkeratosis, alternating orthokeratosis and parakeratosis in a checkerboard pattern, and focal acantholytic dyskeratosis. Descriptions and therapeutic experiences are mainly based on case reports. Mostly, systemic retinoids, methotrexate, and other immunosuppressive agents as well as UV light therapy are applied, with varying response rates. In recent years, treatment with so-called 'biologics' is becoming more and more popular for treating recalcitrant PRP. We present a review of the clinical features, histopathologic findings, classification, differential diagnoses, and treatment of PRP.

  1. Long-term ustekinumab treatment for refractory type I pityriasis rubra pilaris.

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    Di Stefani, Alessandro; Galluzzo, Marco; Talamonti, Marina; Chiricozzi, Andrea; Costanzo, Antonio; Chimenti, Sergio

    2013-03-30

    Pityriasis rubra pilaris is a rare, chronic erythematous squamous disorder of unknown etiology. The disease is characterized initially by small follicular papules that coalesce into yellowish pink scaly plaques, palmoplantar keratoderma, diffuse furfuraceous scale of the scalp, and frequent progression to exfoliative erythroderma. Generally it is difficult to discern pityriasis rubra pilaris from other skin conditions but key-clinical features help in the diagnosis such as "islands" of spared skin within generalized erythroderma, follicular keratotic plugs, and an orange hue of the involved skin. Treatment options include topical vitamin D analogues, keratolytics, systemic acitretin, methotrexate, cyclosporine, azathioprine, fumaric acid esters, phototherapy, and anti-TNFα agents. Cases, of pityriasis rubra pilaris, successfully treated with a short-course ustekinumab therapy, have been reported. We report a 31-year-old man with pityriasis rubra pilaris, refractory to conventional treatments, successfully treated with ustekinumab monotherapy for over 64 weeks. After failing conventional systemic agents (cyclosporine, aciretin and methotrexate), ustekinumab 45 mg has been prescribed, with the same dosing regimen as in psoriasis. The patient improved dramatically within 4 weeks of the first injection, with markedly less erythema and pruritus. Long-term control of the disease of the disease was achieved (64 weeks of treatment). We report this case in order to show the striking and rapid efficacy of ustekinumab in reducing the signs and symptoms of the disease. Complete remission was achieved after the third injection, but also a long-term control of the disease. The therapy was well-tolerated in our patient and no adverse events occurred.

  2. Late onset pityriasis rubra pilaris type IV treated with low-dose acitretin.

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    Mota, Fernando; Carvalho, Sandrina; Sanches, Madalena; Selores, Manuela

    2016-01-01

    Pityriasis rubra pilaris is a chronic inflammatory dermatosis of unknown etiology and great clinical variability. It has been divided into six categories. Types III, IV, and V occur in childhood and are distinguished by their clinical presentation, age of onset, and course. We report a 19-year-old male patient with a 2-week history of pruritic, scaling dermatosis of the hands, feet, elbows, and knees. He had no family history of skin disease. On physical examination, we observed circumscribed, reddish-orange, scaling plaques affecting the elbows and knees and a waxy palmoplantar keratoderma. The skin biopsy showed acanthosis, alternating orthokeratosis, parakeratosis, and follicular plugging suggestive of pityriasis rubra pilaris. The patient started treatment with oral acitretin, 25 mg every other day. The treatment was tolerated well, and after 6 months the lesions had resolved completely. Pityriasis rubra pilaris is a chronic papulosquamous disorder of unknown pathogenesis, characterized by reddish-orange scaly plaques, palmoplantar keratoderma, and keratotic follicular papules. There is still no consensus regarding the treatment, but therapeutic options include systemic retinoids, particularly acitretin in the recommended dose of 0.5 to 0.75 mg/kg/day. In our case, the patient was treated with a low-dose regimen of acitretin, which was effective and well tolerated.

  3. Sofosbuvir-Induced Erythrodermic Pityriasis Rubra Pilaris-Like Drug Eruption.

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    Cheung, Evelyn J; Jedrych, Jaroslaw J; English, Joseph C

    2015-10-01

    Until 2011, the standard-of-care therapy for patients with hepatitis C consisted of interferon and ribavirin. The recent advent of new targeted therapies against this virus has provided more options of treatment for infected patients. Sofosbuvir, a nucleotide inhibitor of hepatitis C virus (HCV) RNA polymerase, was recently approved by the US Food and Drug Administration in 2013. Various Phase 3 trials with sofosbuvir combination therapy have reported an incidence of rash between 7% and 18%. We here describe a case of sofosbuvir-induced erythrodermic pityriasis rubra pilaris-like drug eruption.

  4. Acantholytic Pityriasis Rubra Pilaris Associated with Imiquimod 3.75% Application

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    Natasha Atanaskova Mesinkovska

    2011-01-01

    Full Text Available Imiquimod is an immunomodulator with both antitumor and antiviral properties. It is currently available in two cream formulations as Aldara (imiquimod 5% and the newly approved Zyclara (imiquimod 3.75%. Imiquimod has been associated with localized erythema, crusting, and scaling at the site of application. However, more severe generalized skin eruptions including erythema multiforme, psoriasis, and hyperpigmentation have been described. The newly approved imiquimod 3.75% cream is a presumably safer alternative due to its lower concentration. This paper describes the development of generalized acantholytic pityriasis rubra pilaris after the treatment of an actinic keratosis on the forehead with imiquimod 3.75% cream.

  5. Acute cutaneous graft-versus-host disease resembling type II (atypical adult) pityriasis rubra pilaris.

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    Surjana, Devita; Robertson, Ivan; Kennedy, Glen; James, Daniel; Weedon, David

    2015-02-01

    We present a case of cutaneous acute graft-versus-host disease (aGVHD) with confluent erythematous perifollicular hyperkeratosis and ichthyosiform scale in the clinical pattern of type II (atypical adult) pityriasis rubra pilaris (PRP), which developed 26 days after allogeneic peripheral blood stem cell transplant. Skin histology confirmed features of both aGVHD and PRP. The skin lesions were refractory to oral prednisolone and cyclosporine and only partially responsive to a combination of i.v. methylprednisolone, oral tacrolimus, oral mycophenolate mofetil, and infusions of anti-thymocyte globulin and the tumour necrosis factor-α inhibitor, etanercept. © 2013 The Australasian College of Dermatologists.

  6. Pityriasis Rubra Pilaris: A Report of Two Cases and Literature Review

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    Paravina Mirjana

    2015-12-01

    Full Text Available Pityriasis rubra pilaris (PRP is an idiopathic inflammatory hyperproliferative chronic dermatosis characterized by: perifollicular coalescing papules with central keratotic acuminate plugs gradually submerged in sheets of erythema; perifollicular erythema with islands of unaffected skin; palmoplantar keratoderma; diffuse desquamation which typically spreads from the head down to the feet. The cause of the condition is unknown, but possible etiological factors include: vitamin A deficiency, trauma, infections, autoimmune mechanisms, and malignancies. Taking into account different age of onset, clinical course, morphology and prognosis, there are six different types of the disease: two in adults (classical and atypical; three in children (classical, circumscribed and atypical; one in individuals infected with human immunodeficiency virus.

  7. A case of pityriasis rubra pilaris with associated focal acantholytic dyskeratosis complicated by Kaposi's varicelliform eruption.

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    Erdag, Gulsun; Lockman, Deborah; Tromberg, Jennifer; Cropley, Thomas; Patterson, James W

    2011-11-01

    The clinical and histopathological diagnosis of pityriasis rubra pilaris (PRP) can be difficult because clinical findings are often subtle in early stages, and microscopic findings can overlap with those of other skin diseases. Focal acantholytic dyskeratosis (FAD) can rarely be seen in PRP and can mimic Darier's disease, Grover's disease or other disorders characterized by these histopathologic features. Kaposi's varicelliform eruption is a widespread infection due to herpes simplex virus (HSV) types 1 and 2, coxsackievirus A16 or vaccinia virus, occurring in a preexisting dermatosis; only one case has been reported in PRP. We report a patient with PRP whose biopsies showed both herpes simplex infection and FAD. A complete understanding of the mechanism behind this eruption evolved gradually, aided in great measure by the histopathologic findings. Copyright © 2011 John Wiley & Sons A/S.

  8. Type I pityriasis rubra pilaris: upregulation of tumor necrosis factor alpha and response to adalimumab therapy.

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    Zhang, Yao-Hua; Zhou, Youwen; Ball, Nigel; Su, Ming-Wan; Xu, Jin-Hua; Zheng, Zhi-Zhong

    2010-01-01

    pityriasis rubra pilaris (PRP) has unknown etiology and is often refractory to conventional therapies. to document a PRP patient's response to adalimumab therapy and to highlight the potential role of tumor necrosis factor (TNF) in the development of PRP skin lesions. a patient received adalimumab therapy at standard dosing intervals. In addition, the messenger ribonucleic acid (mRNA) of TNF in the lesional and perilesional normal skin was quantified in two patients with PRP. the patient responded to adalimumab therapy and achieved clinical remission by 4 months. There was a significant elevation of TNF mRNA in the lesional skin of PRP. TNF upregulation is detected in PRP lesional skin, consistent with the observed clinical efficacy of TNF blockade for the treatment of PRP.

  9. Ustekinumab as an Alternative Treatment Option for Chronic Pityriasis Rubra Pilaris

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    Mudit Chowdhary

    2015-03-01

    Full Text Available Pityriasis rubra pilaris (PRP is an exceptionally rare, chronic inflammatory dermatosis of unknown etiology. Patients classically present with small, follicular keratosis and salmon-colored plaques that begin at the head and neck and slowly progress to widespread erythroderma including the palms and soles. It is difficult to distinguish PRP from other inflammatory dermatoses; however, features that help aid in the diagnosis include ‘islands' of spared skin, orangish hue and typical findings on biopsy. There are no specific guidelines on therapy and treatment options include corticosteroids, vitamin D analogs, retinoids, methotrexate, cyclosporine, azathioprine and tumor necrosis factor alpha antagonists. Unfortunately options are limited for patients when these drugs do not work. We report a case of chronic PRP, refractory to conventional treatment, successfully treated with ustekinumab monotherapy. The patient was treated with 90 mg subcutaneous ustekinumab injections and began to show improvement within only 8 weeks. Long-term control of the disease has been attained without any significant side effects. We report this case to show that ustekinumab can be used as an alternative treatment method for patients with chronic, unremitting PRP. Treatment response is remarkably rapid and the infrequent dosing leads to patient compliance and a significantly improved quality of life.

  10. Familial pityriasis rubra pilaris is caused by mutations in CARD14.

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    Fuchs-Telem, Dana; Sarig, Ofer; van Steensel, Maurice A M; Isakov, Ofer; Israeli, Shirli; Nousbeck, Janna; Richard, Katharina; Winnepenninckx, Veronique; Vernooij, Marigje; Shomron, Noam; Uitto, Jouni; Fleckman, Philip; Richard, Gabriele; Sprecher, Eli

    2012-07-13

    Pityriasis rubra pilaris (PRP) is a papulosquamous disorder phenotypically related to psoriasis. The disease has been occasionally shown to be inherited in an autosomal-dominant fashion. To identify the genetic cause of familial PRP, we ascertained four unrelated families affected by autosomal-dominant PRP. We initially mapped PRP to 17q25.3, a region overlapping with psoriasis susceptibility locus 2 (PSORS2 [MIM 602723]). Using a combination of linkage analysis followed by targeted whole-exome sequencing and candidate-gene screening, we identified three different heterozygous mutations in CARD14, which encodes caspase recruitment domain family, member 14. CARD14 was found to be specifically expressed in the skin. CARD14 is a known activator of nuclear factor kappa B signaling, which has been implicated in inflammatory disorders. Accordingly, CARD14 levels were increased, and p65 was found to be activated in the skin of PRP-affected individuals. The present data demonstrate that autosomal-dominant PRP is allelic to familial psoriasis, which was recently shown to also be caused by mutations in CARD14. Copyright © 2012 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

  11. New-onset vitiligo during long-term, stable infliximab treatment of pityriasis rubra pilaris.

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    Mattox, Adam R; Chappell, Jeaneen A; Hurley, M Yadira

    2013-02-01

    Incidents of new-onset vitiligo attributed to infliximab therapy for rheumatoid arthritis and ulcerative colitis have been reported. Reported cases share a common theme in that symptoms manifested in close proximity to the initiation or significant dose increase of the medication. This case describes the presentation of infliximab-induced vitiligo in a patient using it for long-term treatment of stable pityriasis rubra pilaris. The patient was initiated and titrated to a stable dose of infliximab totaling 27 months' duration. He was able to achieve near-complete resolution of symptoms before developing depigmented patches consistent with vitiligo. Infliximab was discontinued. Tacrolimus 0.1% ointment and narrow-band ultraviolet B light successfully repigmented the patches. The association of discontinuing infliximab and resolution of vitiligo suggests infliximab had a role in this case. Though the mechanism of involvement is undetermined, infliximab may have induced an autoimmune process by paradoxically activating lymphocytes. Alternatively, infliximab antibodies may have led to the process by disrupting the normal balance of cytokines.

  12. Interleukin 23-Helper T Cell 17 Axis as a Treatment Target for Pityriasis Rubra Pilaris.

    Science.gov (United States)

    Feldmeyer, Laurence; Mylonas, Alessio; Demaria, Olivier; Mennella, Anna; Yawalkar, Nikhil; Laffitte, Emmanuel; Hohl, Daniel; Gilliet, Michel; Conrad, Curdin

    2017-04-01

    Treatment of pityriasis rubra pilaris (PRP) is solely based on its resemblance to psoriasis rather than any knowledge of its pathomechanism. Insight into pathogenic mediators of inflammation is essential for targeted and valid treatment options that could replace previous serendipitous therapeutic approaches in refractory PRP. To determine whether blockade of the interleukin 23-helper T cell 17 (IL-23-TH17) pathway with ustekinumab represents an efficacious and, based on its proinflammatory cytokine profile, targeted treatment option in PRP. In this case report, a patient with PRP received outpatient treatment at a university hospital department of dermatology with ustekinumab according to the dosing regimen approved for psoriasis. Lesional skin biopsy samples were taken from this patient and 2 others with refractory PRP. Messenger RNA (mRNA) expression of proinflammatory innate and T-cell-derived cytokines were measured and compared with skin samples from patients with psoriasis and healthy donors. From 1 patient, lesional skin samples were taken before ustekinumab treatment and 4 and 28 weeks after treatment initiation. Follow-up was completed after 6 months. Subcutaneous ustekinumab, 45 mg, at weeks 0 and 4 and quarterly thereafter. The primary outcome was to determine the changes in expression of proinflammatory innate and T-cell-derived cytokines during ustekinumab therapy. The secondary objective was to evaluate the clinical and histopathologic phenotype in relation to the mRNA expression profile of proinflammatory cytokines. In lesional PRP skin samples from a single patient, upregulated expression levels were found for most proinflammatory innate cytokines, including tumor necrosis factor (TNF), IL-6, IL-12, IL-23, and IL-1β. Among adaptive T-cell cytokines, an increase of TH1 cytokines and, in particular, TH17 cytokines IL-17A, IL-17F, and IL-22 was seen in PRP. The patient with PRP who received ustekinumab showed regression of skin lesions after 2 weeks

  13. Severe, Disfiguring, Pityriasis Rubra Pilaris in a Woman in the Dominican Republic: Histopathologic Diagnosis and Response to Antiretroviral Therapy.

    Science.gov (United States)

    Lerebours-Nadal, Leonel; Beck-Sague, Consuelo M; Parker, Douglas; Gosman, Amanda; Saavedra, Arturo; Engel, Kristy; Dean, Andrew G

    2016-01-01

    Pityriasis rubra pilaris (PRP) is a poorly understood dermatologic condition usually accompanied by keratoderma and intense erythroderma with islands of unaffected skin. The PRP categories include HIV-associated PRP VI. A 23-year-old HIV-infected, dark-skinned woman in the Dominican Republic developed an extremely severe, disfiguring process characterized first by a dry scaly rash involving her face, trunk, and extremities with hyperpigmentation and islands of spared skin and minimal erythroderma, followed by alopecia and development of a thick horny layer on the scalp and face. The condition, histologically proven to be PRP, was accompanied by fever, wasting, and decline in CD4 count. Initiation of combination antiretroviral therapy (cART) was followed by rapid and sustained resolution of PRP. Nine years after ART initiation, she remains well, with viral suppression and immune recovery, without PRP recurrence but with sparse hair regrowth and facial scarring. In some dark-skinned patients, severe PRP may not feature characteristic erythroderma but will respond to combination ART. © The Author(s) 2015.

  14. Association pityriasis rubra pilaire et myasthenie

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    Fatima Zahra Agharbi

    2011-09-01

    Full Text Available Le pityriasis rubra pilaire est un trouble de keratinisation rare dont l�etiopathogenie reste inconnue mais dont l�association avec autres pathologies a ete deja rapportee. Nous rapportons l�observation d�une jeune patiente qui presente un pityriasis rubra pilaire associe a une myasthenie. Traitee par Neostigmine et thymectomie avec bonne evolution sur le plan neurologique. Vu son desir de grossesse un traitement systemique de son pityriasis rubra pilaire n�a pas pu etre instaure et l�evolution sous dermocorticoides n�etait pas tres favorable.

  15. Pityriasis amiantacea.

    Science.gov (United States)

    Moon, C M; Schissel, D J

    1999-03-01

    Pityriasis amiantacea is an easily recognizable cutaneous disease that is characterized by scaling of the scalp and temporary alopecia. The scaling, described as thick and asbestos-like, binds down tufts of hair. The alopecia may be temporary or scarring. Despite a well-established clinical description, no definitive etiology has been uncovered. This disease may represent seborrheic dermatitis, superficial fungal or pyogenic infections, lichen planus, or psoriasis. Histologically, the disease is characterized by eczematous features. We report a case of pityriasis amiantacea in an 11-year-old girl with simultaneous findings of psoriasis as well as review the literature on the etiology of this disease.

  16. Case report. Pityriasis versicolor mimicking Pityriasis rotunda.

    Science.gov (United States)

    Aste, Nicola; Pau, Monica; Aste, Natalia; Biggio, P

    2002-04-01

    Pityriasis versicolor is a common dermatomycosis, occurring throughout the world, characterized by irregular, slightly scaly patches, varying in color from red/light brown to white. Pityriasis rotunda, on the other hand, is an uncommon disease, reported in specific ethnic groups, and characterized by perfectly round or oval patches of varying color, with a scaly surface. The histologic pattern is that of ichthyosis vulgaris. We report here the case of a male patient, aged 31, from Sardinia (Italy), affected by Pityriasis versicolor mimicking Pityriasis rotunda. Mycological examination allowed us to formulate the correct diagnosis, and ensuing treatment with antifungal drugs was entirely successful. The authors, while pointing out the rarity of this case, stress the possibility that Pityriasis versicolor mimics Pityriasis rotunda and vice-versa, especially in those countries in which the two diseases are endemic. More widespread recourse to microscopic examination can help avoid the risk of mistaken diagnosis and consequent incorrect treatment.

  17. [Clinical trial of a topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil and sodium pyruvate, in several hyperkeratotic skin conditions].

    Science.gov (United States)

    Ferrando, J

    1986-01-01

    A topical clinical trial with preparations containing urea and sodium pyruvate has been made. It was used for diverse hyperkeratotic skin conditions (psoriasis, xerosis, pityriasis rubra pilaris, stuccokeratosis, seborrheic dermatitis, stasis dermatitis, pityriasis lichenoides chronica). A month later a clinical improvement was evident in all cases except in pityriasis lichenoides.

  18. Pityriasis versicolor alba.

    Science.gov (United States)

    Thoma, W; Krämer, H-J; Mayser, P

    2005-03-01

    Pityriasis versicolor alba is a hypopigmented or depigmented variant of pityriasis versicolor characterized by maculous, partly pityriasiform, scaly depigmented lesions occurring particularly in seborrhoeic areas. Long-persisting hypopigmentation after healing of the pityriasis versicolor was first described by Gudden in 1853. Hypopigmentation and depigmentation were later differentiated as an independent variant of the disease. In 1848, Eichstedt recognized the pathogen-related character of pityriasis versicolor in its hyperpigmented form. Today it is generally accepted that the disease is caused by yeasts of the genus Malassezia, of which nine species are differentiated. It is controversial whether a single species is responsible for the disease. The pathogenesis of depigmentation has not been established. A screening effect by the scale layer as well as toxic effects on pigment synthesis by fungal metabolites have been discussed. With regard to the second mechanism, the newly discovered tryptophan-derived metabolites of M. furfur might be significant. Evidence-based data concerning the therapy of pityriasis versicolor alba do not exist. According to current recommendations, pityriasis versicolor should be rapidly treated with antimycotics, followed by ultraviolet therapy to induce maturation of existent melanosomes and accelerate repigmentation. However, depigmented lesions are difficult to improve by ultraviolet therapy.

  19. Pityriasis alba with poliosis.

    Science.gov (United States)

    Malik, Tayyaba Gul; Khalil, Muhammad; Bhatti, Muhammad Moeen

    2014-02-01

    Pityriasis alba is a skin disease, commonly seen in children and young adults. This case presents the ocular association of this disease in a 10 years old Pakistani male. Ocular features in this case were poliosis, tilted disc, high myopia and chorioretinal degeneration. Tilted discs and high myopia can be coincidental but poliosis and decreased pigment in retinal pigment epithelium are closely related with the hypopigmentation seen in this disease.

  20. Unilateral generalized keratosis pilaris following pregnancy.

    Science.gov (United States)

    Zhu, Jian-Wei; Lu, Zhong-Fa; Zheng, Min

    2014-10-01

    Keratosis pilaris (KP) is a common inherited disorder characterized by small folliculocentric keratotic papules that may have surrounding erythema, which gives the skin a stippled appearance resembling gooseflesh. The extensor surfaces of the upper arms, thighs, and buttocks commonly are affected, but a generalized presentation may occur. We report the case of a 29-year-old woman with unilateral generalized KP in the second month of her second pregnancy. Both a genetic mutation and pregnancy-induced hormonal changes played possible roles in the development and progress of unilateral generalized KP in this patient.

  1. Pityriasis lichenoides and lymphomatoid papulosis.

    Science.gov (United States)

    Rogers, M

    1992-03-01

    The clinical features, histopathology, immunopathology, and management of pityriasis lichenoides and lymphomatoid papulosis are discussed, with particular emphasis on the pediatric aspects of these conditions. The difficulties in logically separating pityriasis lichenoides into an acute (pityriasis lichenoides et varioliformis acuta) and a chronic (pityriasis lichenoides chronical) form are addressed. The development of lymphoreticular malignancy in patients with lymphomatoid papulosis has been well documented, but pityriasis lichenoides has characteristically been regarded as a benign condition. However, recent reports of the development of large plaque parapsoriasis in patients with pityriasis lichenoides have led to a reconsideration. Some of these patients were in the pediatric age group. Although there are significant clinical, histopathological, and immunopathological differences between pityriasis lichenoides and lymphomatoid papulosis, the demonstration of similar clonal T cell receptor gene rearrangements and the confirmation of the potentially premalignant nature of both suggests that there may indeed be an interrelationship between these two controversial entities. Close follow-up of patients with both of these conditions is recommended, with observation being discontinued only when the patient has been free of lesions for several years.

  2. Uncommon cases of pityriasis versicolor.

    Science.gov (United States)

    Romano, C

    2008-06-01

    Malassezia may play a role in several dermatoses. It is responsible for foliculitis and mainly for pityriasis versicolor. Pityriasis versicolor is the most known dermatitis because of its clinical aspects and frequently for its poor response to the therapy, mainly in chronic forms. The clinical aspects of uncommon and rare forms of pityriasis versicolor have been reported. The data related to the patients observed in the last thirty years in Siena are reported. In addition, a study was carried out in Pisa by Professor F. Mancianti to identify species of Malassezia isolated in 37 patients.

  3. Vesicular palmoplantar pityriasis rosea.

    Science.gov (United States)

    Singh, Varinder; Sharma, Meghna; Narang, Tarun; Madan, Manas

    2012-01-01

    A 16-year-old young man presented with intensely itchy erythematous dermatitis on the body for 1 week and vesicular lesions on the palms and soles for 4 to 5 days. Lesions on the palms and soles were accompanied by severe burning and itching. The patient gave a history of sore throat and fever, 1 week prior to the onset of lesions. A general physical examination was normal, and cutaneous examination revealed multiple, well-defined erythematous scaly plaques with collaret scaling on the trunk and extremities (Figure 1). Vesicular lesions were seen on the palms and soles (Figure 2). The differential diagnoses we considered were pityriasis rosea and secondary syphilis. The possibility of dermatophytid, vesicular pityriasis rosea, and pompholyx was limited to the palms and sole lesions. Complete blood cell count was within normal limits. Results from antistreptolysin O titer, potassium hydroxide mount, and venereal disease research laboratory were negative. Skin biopsies were taken from the back and left palm. The biopsy specimen from the back revealed focal spongiosis, lymphocyte exocytosis, vacuolar changes in the basal layer, and perivascular lymphocytic infiltrate in the dermis (Figure 3). The biopsy obtained from the vesicular lesion on the left palm revealed an intraepidermal vesicle with no evidence of acantolytic process (Figure 4). A diagnosis of pityriasis rosea was made and the patient was started on clarithromycin 500 mg once a day for 7 days, along with antihistamines and emollients. The lesions faded dramatically in a very short period, and there was significant involution of almost all of the lesions after 7 days of clarithromycin. During the 6 months of follow-up, no recurrence was observed.

  4. Granulosis rubra nasi

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    Cynthia Sargunam

    2013-01-01

    Full Text Available Granulosis rubra nasi is a rare disorder of the eccrine glands, inherited as an autosomal dominant trait. It is clinically characterized by hyperhidrosis of the central part of the face, most conspicuous on the tip of the nose, followed by appearance of diffuse erythema over the nose, cheeks, chin, and upper lip. It is commonly seen in childhood, but can also occur in adults. This is a case report of a 27-year-old male patient who presented with excessive sweating over the nose. Physical examination of the nose revealed erythema and multiple telangiectatic vesicles. Biopsy findings supported the diagnosis of granulosis rubra nasi. This case is being reported for its rarity since to the best of our knowledge, it has not been reported in Indian subjects so far.

  5. Does pityriasis rosea Koebnerise?

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    Nwabudike Lawrence Chukwudi

    2013-04-01

    Full Text Available The Koebner phenomenon or isomorphic phenomenon is described in dermatology texts as the production of lesions of the original disease, in clinically uninvolved skin, following trauma. The lesions are located at the site of trauma and evidence of a traumatic causation is the linear arrangement of some of the lesions, such as in the case of lichen planus. Other disorders known to exhibit the Koebner phenomenon include psoriasis and vitiligo. A number of other diseases are associated with the Koebner phenomenon. Pathergy is a phenomenon of pustule production following trauma, which occurs in certain disorders such as Pyoderma gangrenosum and Behçet?s disease. In some disorders such as impetigo and verruca vulgaris, inoculation may give the appearance of the Koebner phenomenon. A case of pityriasis rosea and Koebner phenomenon at the site of routine blood assay is described in this work. This author has not thus far encountered any description of the Koebner reaction in relation to pityriasis rosea in the literature, but, perhaps, with this report, other physicians will be more open to this possibility and actually uncover similar cases.

  6. Blaschkoid pityriasis versicolor.

    Science.gov (United States)

    Tan, Cheng; Zhu, Wen-Yuan; Min, Zhong-Sheng

    2010-07-01

    A 31-year-old male patient complained of having follicular and brownish red maculopapules along the Blaschko's lines on the right chest for 2 days. On examination, follicular brownish maculopapules were present on the chest with a uniform size of about 3 mm in diameter. The lesions were isolated without a tendency to merge, giving several S-shaped, band-like appearances. Direct mycological examination of the skin flakes revealed many pseudomycelial hyphae and yeast cells with typical spaghetti and meatball appearance. Wood's light examination of the lesion revealed a golden yellow fluorescence. A diagnosis of blaschkoid pityriasis versicolor was suggested because of blaschkoid distribution of the lesions in this new variant of PV.

  7. Relapsing pityriasis rosea.

    Science.gov (United States)

    Drago, Francesco; Ciccarese, Giulia; Rebora, Alfredo; Parodi, Aurora

    2014-01-01

    To assess the prevalence of relapses of pityriasis rosea (PR), a retrospective cohort study investigated all PR cases diagnosed in Genoa between 2000 and 2013 and followed them up to today. Of 570 cases, 21 (3.7%) relapsed. Most of them had a single episode, but 4 had two episodes and 2 had three episodes. The herald patch was always absent, size and number of the lesions were reduced, and duration was shorter than that of the primary episodes. Constitutional symptoms were present, though less severe than in the primary eruption. Most recurrences occurred within 1 year (16/21, 76.2%). Men outnumbered women and the mean age of the relapsing patients (20.3 years) was higher than that for the primary episode. A pathogenetic hypothesis is provided: since PR is associated with reactivation of human herpesvirus 6/7, a parallelism with other typical reactivating human herpesviruses (varicella zoster virus and Epstein-Barr virus) has been established.

  8. Pityriasis rosea - An update

    Directory of Open Access Journals (Sweden)

    Chuh Antonio

    2005-01-01

    Full Text Available Recent controversies on the etiology, diagnosis and treatment have led to increased interest in pityriasis rosea (PR. We review these aspects of the disease. PR is universal. The incidence is around 0.68 per 100 dermatological patients, or 172.2 per 100,000 person-years. The prevalence in people aged between 10 and 29 years is 0.6%. The male to female ratio is around 1: 1.43. Evidence on seasonal variation is conflicting, but there is no evidence that the incidence is dependent on mean air temperature, mean total rainfall, or mean relative humidity. Spatial-temporal and temporal clustering of cases of PR has been reported. The association of PR with human herpesvirus-7 infection is still controversial. Owing to the extreme high sensitivities of sequence-based detection methods such as polymerase chain reaction, novel criteria should be applied to evaluate the evidence. There is no evidence that PR is associated with other viral or bacterial infections. The role of autoimmunity in PR warrants further investigations. Many patients with PR have one or more atypical features. Application of validated diagnostic criteria may be helpful for atypical cases. The efficacy of macrolides, including erythromycin, in PR is still under evaluation. There is no evidence that antiviral agents are effective. The efficacies of ultraviolet radiotherapy and systemic corticosteroids are not well established. In managing a patient with PR, we should concentrate more on how the eruption is affecting the quality of life, i.e. the illness, rather than the extent and severity of the eruption, i.e. the disease.

  9. Pityriasis amiantacea: a case report.

    Science.gov (United States)

    Ayanlowo, O O; Olowoyo, O O; Akinkugbe, A O; Adelekan, F A; Ahamneze, N C

    2014-06-01

    Pityriasis amiantacea (PA) is a papulosquamous condition of the scalp,characterized by asbestos - like thick scales attached to the hair shaft. It is thought to represent a reaction pattern to inflammatory skin disorders like psoriasis, seborrhoeic dermatitis, tinea capitis, atopic dermatitis and lichen planus, rather than a distinctive disease. The scaling may be localised or generalised, depending on the underlying condition and its duration.This report highlights the clinical features of pityriasis amiantacea secondary to atopic dermatitis and the differential features of other papulo-squamous scalp disorders such as scalp psoriasis, seborrhoeic dermatitis and lichen planus.Scalp psoriasis and seborrhoeic dermatitis are the commonest causes of PA as well as the closest differentials hence should be excluded in all cases. The longterm sequelae of PA include scalp fibrosis and permanent hair loss hence should be identified and treated promptly. The management modalities of PA will also be discussed.

  10. Pityriasis rosea: A histopathologic study

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    Prasad D

    2000-01-01

    Full Text Available The histopathologic features of pityriasis rosea (PR have been considered by many authors to be compatible with those of dermatitis, but it is not surprising that histological difference may exist between PR and dermatitis. fifty patients of pityriasis rosea were included in this study. We studied the 50 biopsies including 9 biopsies from herald patches. The characteristic features were; absence or decrease of the granular cell layer, extravasation of red blood cells in papillary dermis and partly into the epidermis, dyskeratosis, liquefaction of basal cells, homogenization of papillary collagen, intraepidermal vesicles in apparently dry skin. In addition of these features, we observed prominent delling of epidermis and a typical spongiotic pattern not reported earlier. The biopsies from herald patches showed minor differences from the secondary lesions. We also compared the histopathological features of recent lesions with older lesions.

  11. Pityriasis amiantacea: a study of seven cases*

    Science.gov (United States)

    Amorim, Gustavo Moreira; Fernandes, Nurimar Conceição

    2016-01-01

    Pityriasis amiantacea was first described in 1832. The disease may be secondary to any skin condition that primarily affects the scalp, including seborrheic dermatitis. Its pathogenesis remains uncertain. We aim to analyze the epidemiological and clinical profiles of patients with pityriasis amiantacea to better understand treatment responses. We identified seven cases of pityriasis amiantacea and a female predominance in a sample of 63 pediatric patients with seborrheic dermatitis followed for an average of 20.4 months. We reported a mean age of 5.9 years. Five patients were female, with a mean age of 9 years. All patients were successfully treated with topic ketoconazole. PMID:27828657

  12. Pityriasis amiantacea: a study of seven cases.

    Science.gov (United States)

    Amorim, Gustavo Moreira; Fernandes, Nurimar Conceição

    2016-01-01

    Pityriasis amiantacea was first described in 1832. The disease may be secondary to any skin condition that primarily affects the scalp, including seborrheic dermatitis. Its pathogenesis remains uncertain. We aim to analyze the epidemiological and clinical profiles of patients with pityriasis amiantacea to better understand treatment responses. We identified seven cases of pityriasis amiantacea and a female predominance in a sample of 63 pediatric patients with seborrheic dermatitis followed for an average of 20.4 months. We reported a mean age of 5.9 years. Five patients were female, with a mean age of 9 years. All patients were successfully treated with topic ketoconazole.

  13. Palmar herald patch in pityriasis rosea.

    Science.gov (United States)

    Polat, Mualla; Yildirim, Yasemin; Makara, Anil

    2012-08-01

    Pityriasis rosea is an acute self-limited inflammatory disorder of the skin. The initial clinical features of typical cases are the appearance of a herald patch. The herald patch is commonly located on the thigh, upper arm, trunk or neck; rarely the patch may be on the face, scalp or penis. There are no reports of a palmar herald patch in pityriasis rosea. In this article we present a 14-year-old male patient who had a palmar herald patch with truncal lesions of pityriasis rosea. © 2012 The Authors. Australasian Journal of Dermatology © 2012 The Australasian College of Dermatologists.

  14. Bilateral areolar and periareolar pityriasis versicolor.

    Science.gov (United States)

    Sárdy, Miklós; Korting, Hans Christian; Ruzicka, Thomas; Wolff, Hans

    2010-08-01

    An adolescent boy presented with isolated, symmetrical, bilateral areolar and periareolar pityriasis versicolor. This extremely rare condition should be considered in the differential diagnosis of light brown patches on the areolae.

  15. Pityriasis Amiantacea-Like Eruptions in Scalp: A Novel Manifestation of Pityriasis Rosea in a Child

    Science.gov (United States)

    Zawar, Vijay

    2010-01-01

    Unusual clinical features are known in pityriasis rosea (PR). We report a case of a child who presented with onset of PR in scalp, clinically mimicking pityriasis amiantacea. Careful clinical observations and follow-up led us to appropriate diagnosis. PMID:21712901

  16. Management of seborrheic dermatitis and pityriasis versicolor.

    Science.gov (United States)

    Faergemann, J

    2000-01-01

    Pityriasis (tinea) versicolor and seborrheic dermatitis are two very common skin diseases. Pityriasis versicolor is a chronic superficial fungal disease usually located on the upper trunk, neck, or upper arms. In pityriasis versicolor, the lipophilic yeast Malassezia (also know as Pityrosporum ovale or P. orbiculare) changes from the blastospore form to the mycelial form under the influence of predisposing factors. The most important exogenous factors are high temperatures and a high relative humidity which probably explain why pityriasis versicolor is more common in the tropics. The most important endogenous factors are greasy skin, hyperhidrosis, hereditary factors, corticosteroid treatment and immunodeficiency. There are many ways of treating pityriasis versicolor topically. Options include propylene glycol, ketoconazole shampoo, zinc pyrithione shampoo, ciclopiroxamine, selenium sulfide, and topical antifungals. In difficult cases, short term treatment with fluconazole or itraconazole is effective and well tolerated. To avoid recurrence a prophylactic treatment regimen is mandatory. Seborrheic dermatitis is characterized by red scaly lesions predominantly located on the scalp, face and upper trunk. There are now many studies indicating that Malassezia plays an important role in this condition. Even a normal number of Malassezia will start an inflammatory reaction. Mild corticosteroids are effective in the treatment of seborrheic dermatitis. However, the disease recurs quickly, often within just a few days. Antifungal therapy is effective in the treatment of seborrheic dermatitis and, because it reduces the number of Malassezia, the time to recurrence is increased compared with treatment with corticosteroids. Antifungal therapy should be the primary treatment of this disease.

  17. Vulvar pityriasis versicolor in an immunocompetent woman.

    Science.gov (United States)

    Day, Tania; Scurry, James

    2014-07-01

    To report a case of isolated vulvar pityriasis versicolor in a 24-year-old healthy woman. A 24-year-old woman presented with variable color change on the vulva of 8 months in duration. Areas of tan and white skin were observed on the mons pubis. The pubic hair had been shaved. Initially, the paler areas were deemed abnormal suggesting vitiligo, but the biopsy showed normal skin including normal numbers of melanocytes. Subsequently, biopsy of the tan area showed pityriasis versicolor. She was successfully treated with topical 2% ketoconazole, with gradual fading of lesions. With increased body awareness and the current popularity of pubic hair removal, young women may consult clinicians about color changes on the vulva. Clinicians should be aware that vulvar pityriasis versicolor may occur in healthy women with no other skin involvement.

  18. Malassezia Species and Pityriasis Versicolor

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    Gulin Rodoplu

    2016-01-01

    Full Text Available Malassezia species are found in part of the normal human cutaneous commensal flora, however it has been known for many years that the Malassezia yeasts are associated with a number of different human diseases ranging from pityriasis versicolor to seborrhoeic dermatitis. In addition, since the 1980s, they have been reported as causing opportunistic systemic infections. The taxonomy of Malassezia spp. has recently been modified to include 13 obligatorily lipophilic species, plus one non-obligatorily lipophilic species, which only rarely colonizes human hosts and currently the genus consist 14 species as M. furfur, M. pachydermatis, M. sympodialis, M. globosa, M. obtusa, M. slooffiae, M. restricta, M. dermatis, M. japonica, M. nana, M. yamatoensis, M. caprae, M. equina, M. cuniculi. Fastidious growth requirements of Malassezia yeasts defied the initial attempts to culture these organisms and their true identification and the relationship between different species only became apparent with the application of modern molecular techniques. The causative fungus is seen especially in such seborrheic areas as the scalp, face, trunk and upper back. Under the influence of various exogenous or endogenous predisposing factors, these yeasts change from the blastospore form to the mycelial form and become pathogenic. Diagnosis of pityriasis versicolor which is caused by Malassezia species is generally easy and lies on the basis of its clinical appearance and can be confirmed by mycological examination. The diagnosisis is mainly based on direct examination with potassium hydroxide (KOH and demonstration that represents pseudohyphae and blastoconidia as the typical %u201Cspaghetti and meatballs%u201D pattern. Characteristic features of the genus Malassezia include a distinctive morphology and an affinity for lipids in culture. Culture is necessary to recover the infecting strain, especially for epidemiologic purposes and also to test its antifungal susceptibility

  19. Fluconazole and itraconazole in pityriasis versicolor

    Directory of Open Access Journals (Sweden)

    Jaswal Ritu

    1999-01-01

    Full Text Available Pityriasis versicolor is a common superficial fungal infection caused by Malassezia species. It has a high incidence and prevalence in tropical climates. Although it responds well to treatment, relapses and recurrences are frequent. In the present study the therapeutic response of single dose fluconazole (400 mg with itraconazole (100mg twice daily ? 7 days was compared in sixty patients of pityriasis versicolor. No significant statistical difference (p>0.05% was observed between efficacy of two drugs. Therapy with fluconazole is preferable in view of single dose administration and lesser cost as compared to itraconazole.

  20. Pityriasis lichenoides with ulceronecrosis and hyperthermia: A rare variant of pityriasis lichenoides et varioliformis acuta

    OpenAIRE

    Virdi Sarvjit; Kanwar Amrinder; Saikia Uma

    2010-01-01

    Pityriasis lichenoides with ulceronecrosis and hyperthermia (PLUH) is a severe variant of pityriasis lichenoides et varioliformis acuta that is characterized by high fever and papulo-necrotic skin lesions. We report the case of a 49-year-old male with typical features of PLUH along with an unusual manifestation of extensive skin necrosis including involvement of the intertriginous regions. Systemic administration of corticosteroids and antibiotics did not help to control the disease and the p...

  1. Atypical pityriasis versicolor case report

    Directory of Open Access Journals (Sweden)

    Zonunsanga

    2015-04-01

    Full Text Available Pityriasis versicolor is a superficial fungal infection caused by mycelial form of Malassezia spp, which is confined to stratum corneum. It usually present in the trunk as either hypo or hyperpigmented, aymptomatic, round to oval macules of varying sizes, which may merged to form geographic shape. Diagnosis is usually done clinically, or KOH examination which shows typical spagetti and meat balls appearances, or even by wood’s lamp which shows orange to yellow fluorescence. The case series had been recording in between 2012 to 2013. Within that period, we had recorded 32 cases. All the patients which we had recorded presented with multiple, asymptomatic macules of small sizes varying from 1-2 cm in diameter to 3-4mm in diameter, usually round to oval, hypopigmented, non scaly lesions. 26 patients had lesions on forearms, 3 patients had lesions on dorsa of hands bilaterally, 3 patients had similar kind of lesions on thigh. Besnier’s test was positive in 14 (43.75% patients. KOH examinations showed fungal hyphae in 14 (33.33% patients with typical spagetti and meat balls appearances in 9 (8.13% patients. All of them were given and all of them got response and healed within 2-4 months.

  2. Oropharyngeal lesions in pityriasis rosea.

    Science.gov (United States)

    Ciccarese, Giulia; Broccolo, Francesco; Rebora, Alfredo; Parodi, Aurora; Drago, Francesco

    2017-07-17

    Pityriasis rosea (PR) is an exanthematous disease associated with the endogenous systemic reactivation of human herpesvirus-6 (HHV-6) and human herpesvirus-7 (HHV-7). Oropharyngeal lesions may be associated with the exanthema, but anecdotal evidence suggests that few dermatologists are aware of their occurrence. Classifying oropharyngeal lesions in PR, establishing their prevalence, and assessing their possible association with different PR forms. The records of all PR cases diagnosed in the Dermatology Clinic of Genoa University between 2003 and 2016 were retrospectively reviewed to examine sex and age of the patients, PR type, presence of enanthema, systemic symptoms, specific anti-HHV-6 and or HHV-7 serology, and HHV-6 and/or HHV-7 DNA loads. The oropharyngeal mucosa was carefully examined in 527 patients with PR. Painless oropharyngeal lesions were observed in 149 patients with PR (28%) and classified as erythematomacular, macular and papular, erythematovesicular, and petechial lesions. The petechial and macular and papular patterns were those most frequently observed. There was no statistically significant difference in the levels of HHV-6 and HHV-7 viremia in the plasma of patients with enanthema and those without. Because this was a retrospective study, biopsies on mucosal lesions were not performed. Our findings showed that enanthemas are frequently associated with forms of PR different from the classic form. Copyright © 2017 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

  3. Pityriasis rosea-like eruption induced by isotretinoin.

    Science.gov (United States)

    Gürel, Gülhan; Şahin, Sevinç; Çölgeçen, Emine

    2017-04-19

    Pityriasis rosea is a common, self-limited and inflammatory skin disease. The etiology is not clearly known. Viral agents, autoimmunity, psychogenic factors and drugs have all been suggested as risk factors. Isotretinoin is usually used in the treatment of resistant, nodulocytic acne. We present a case of pityriasis rosea-like eruption induced by isotretinoin. To our knowledge, this is the second clinical case of pityriasis rosea-like eruption induced by isotretinoin.

  4. Epidermal Permeability Barrier in the Treatment of Keratosis Pilaris

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    Tanawatt Kootiratrakarn

    2015-01-01

    Full Text Available Objectives. To evaluate and compare the efficacy, safety, hydrating properties, and tolerability of 10% lactic acid (LA and 5% salicylic acid (SA in the therapy of keratosis pilaris (KP. Material and Method. Patients with KP were randomized for treatment with either 10% LA or 5% SA creams being applied twice daily for 3 months. The patients were clinically assessed at baseline and after 4, 8, and 12 weeks of treatment and 4 weeks after treatment. The functional properties of the stratum corneum (SC were determined before treatment, 12 weeks, and follow-up phase by high-frequency conductance and transepidermal water loss (TEWL. Results. At the end of the trial, the mean reduction of the lesions from baseline was statistically significant for 10% LA (66% and 5% SA (52%. During the treatment, higher conductance values were found on both group and this improvement was maintained until the follow up period. No significant differences in transepidermal water loss were observed after treatment. The adverse effects were limited to mild irritation localized on the skin without systemic side effect. Conclusion. The study demonstrated that 10% LA and 5% SA are beneficial to treat KP with the significantly clearance and marked improvement as by instrumental evaluation.

  5. Atrophying pityriasis versicolor: is this a new variant of pityriasis versicolor?

    Science.gov (United States)

    Yang, Yun-Seok; Shin, Min-Kyung; Haw, Choong-Rim

    2010-11-01

    An atypical clinical form of pityriasis versicolor has been infrequently reported, in which cutaneous atrophy is associated with individual pityriasis versicolor lesions. The pathogenesis of this atrophy remains unclear, but is believed to be a delayed-type hypersensitivity reaction to antigens derived from the Malassezia species. A 60-year-old man presented with multiple, slightly scaly, and depressed maculopatches or plaques on the trunk and extremities. Our microscopic examination of the skin scrapings on a KOH preparation revealed numerous short hyphae and spores. The patient was treated daily with 200 mg of itraconazole in combination with topical antifungals, achieving clinical improvement and mycological recovery, which was confirmed upon follow-up 1 month later. This is the first case report of atrophying pityriasis versicolor in Korea. It needs to be differentiated from other atrophying disorders of the skin.

  6. Hypopigmented macules: leprosy, atopy or pityriasis versicolor?

    Science.gov (United States)

    Massone, C; Cavalchini, A; Clapasson, A; Nunzi, E

    2010-12-01

    Lepromatous leprosy (LL) represents the highest infective and multibacillary form of leprosy. Clinical manifestations are consequent to the haematogenous spread of bacilli and include macules, plaques and nodules in a symmetric distribution or a diffuse infiltration of the skin. LL may mimic many different inflammatory and neoplastic skin diseases and in a small percentage of patients, skin manifestation may be atypical. This article reports the case of a South American child with LL presenting with symmetrically distributed hypopigmented macules previously misdiagnosed as pytiriasis alba, atopic dermatitis and pityriasis versicolor. Atopy and pityriasis versicolor are common skin conditions that can be also observed in leprosy patients and that can masquerade the diagnosis of LL, especially if occurring in dark skin. Dermatologists in Europe should be aware of this unusual form of presentation of leprosy and must take in mind Hansen disease in the differential diagnosis in patients coming from endemic areas.

  7. Pityriasis lichenoides chronica in association with Tubercular Lymphadenitis

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    Pandhi R

    1997-01-01

    Full Text Available A patient with pityriasis lichenoides chronica (PLC during the course of her skin disease developed tuberculosis of cervical lymph nodes. Anti-tuberculosis treatment resulted in remission of PLC. Mycobacterium tuberculosis could be one of the triggering agent in pityriasis lichenoides.

  8. Pityriasis lichenoides with ulceronecrosis and hyperthermia: A rare variant of pityriasis lichenoides et varioliformis acuta

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    Virdi Sarvjit

    2010-01-01

    Full Text Available Pityriasis lichenoides with ulceronecrosis and hyperthermia (PLUH is a severe variant of pityriasis lichenoides et varioliformis acuta that is characterized by high fever and papulo-necrotic skin lesions. We report the case of a 49-year-old male with typical features of PLUH along with an unusual manifestation of extensive skin necrosis including involvement of the intertriginous regions. Systemic administration of corticosteroids and antibiotics did not help to control the disease and the patient succumbed to death due to its fulminant nature.

  9. Pityriasis lichenoides with ulceronecrosis and hyperthermia: a rare variant of pityriasis lichenoides et varioliformis acuta.

    Science.gov (United States)

    Virdi, Sarvjit Kaur; Kanwar, Amrinder Jit; Saikia, Uma Nahar

    2010-01-01

    Pityriasis lichenoides with ulceronecrosis and hyperthermia (PLUH) is a severe variant of pityriasis lichenoides et varioliformis acuta that is characterized by high fever and papulo-necrotic skin lesions. We report the case of a 49-year-old male with typical features of PLUH along with an unusual manifestation of extensive skin necrosis including involvement of the intertriginous regions. Systemic administration of corticosteroids and antibiotics did not help to control the disease and the patient succumbed to death due to its fulminant nature.

  10. Narrowband UVB in Treatment of Pityriasis Lichenoides

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    Evren Odyakmaz Demirsoy

    2012-12-01

    Full Text Available Objective: Pityriasis Likenoides (PL is an inflammatory skin disease with unknown cause. Currently, the disease is considered as one of the rare indications of narrowband ultraviolet (UV B and is treated in phototherapy units. However, literature about treatment results is still limited. The aim of this study was to investigate the effectiveness of narrowband UVB therapy for PL and also to compare these results with other study results. Methods: Patients who were diagnosed with pityriasis lichenoides chronica (PLK or pityriasis lichenoides et varioliformis acuta (PLEVA clinically and histopathologically and treated with narrowband UVB in our phototherapy unit through 2000 to 2011 were evaluated retrospectively. Results: Three of the patients were diagnosed with PLEVA, and also 14 of them as PLK through the group of 17 patients included in the study. Four patients (23.5% had complete response, 6 (35.3% had prominent response, 4 (23.5% had partial response and 3 (17.7% were unresponsive after a mean of 36.9 sessions. Eight patients could be reached, in this group 7 patients did not have a relapse in the 41.4 months period and only one patient had a relapse 24 weeks after treatment. Conclusion: It was assumed that narrowband UVB was a safe treatment method for PL.

  11. Pityriasis lichenoides in an Asian population.

    Science.gov (United States)

    Koh, Wei-Liang; Koh, Mark Jean-Aan; Tay, Yong-Kwang

    2013-12-01

    There are few studies comparing pityriasis lichenoides (PL) in adults and children, with fewer involving Asians. We compared the clinical profile and treatment outcomes of 10 adults and five children diagnosed with PL. We retrospectively reviewed a series of patients diagnosed with PL at our hospital from 2002 to 2008. We identified 10 adults and five children (nine adults and four children with pityriasis lichenoides chronica; one adult and one child with pityriasis lichenoides et varioliformis acuta). Mean age of onset of disease was 42.2 years in adults and 12.2 years in children. Median duration of disease before presentation was 5.5 months in adults and 6 months in children. Trunk and limbs were the most common sites of involvement. Itch was present in the majority. Almost all patients did not respond to topical corticosteroids. A good response was seen in three adults and two children treated with oral antibiotics. Three adults and two children responded to treatment with narrow-band ultraviolet B phototherapy. The median time to resolution was 8 months in adults and 21 months in children. Postinflammatory dyspigmentation was seen in six adults and four children. PL presents similarly in adults and children; however, it runs a longer course in children. In our series, postinflammatory hyperpigmentation was common, which may be explained by our patients' darker skin phototypes. We routinely prescribe oral antibiotics initially in patients without contraindications. Phototherapy may be useful in patients not responding to antibiotics. © 2013 The International Society of Dermatology.

  12. Prevalence of pityriasis versicolor in young Italian sailors.

    Science.gov (United States)

    Ingordo, V; Naldi, L; Colecchia, B; Licci, N

    2003-12-01

    Pityriasis versicolor is a superficial fungal disease with a world-wide distribution, but there are few available studies on its prevalence in the general population. To assess the prevalence of pityriasis versicolor in a representative sample of young Italian sailors, evaluating the influence of habits and risk factors in the affected individuals. Young cadets (n = 1024: 975 men and 49 women, mean age 22 years) of the Italian Navy Petty Officers' School in Taranto were consecutively examined by the same observer. The diagnosis of pityriasis versicolor was based on clinical picture and/or Wood's lamp examination. All the subjects filled in a questionnaire about sport practice, swimming pool attendance, marching, presence of hyperhidrosis and a positive clinical history of pityriasis versicolor in the past. The affected individuals were also asked if they were aware of their skin lesions. Differences between answers of affected and unaffected subjects were tested by Fisher's exact P-value test, and odds ratios were calculated. Pityriasis versicolor was diagnosed in 22 subjects (2.1%), all men, of whom 15 (68%) were not aware of their condition. No statistical association was found between active pityriasis versicolor and sport practice, swimming pool attendance, marching or presence of hyperhidrosis. A significant association [odds ratio 8.7 (95% confidence interval 3.3-21.5); Fisher's exact P-value test P history of pityriasis versicolor. The prevalence of pityriasis versicolor in this sample of young Italian sailors was not high, in agreement with the available surveys performed in the general population in temperate climates. Many affected subjects were not aware of their condition. The only important factor associated with pityriasis versicolor was a previous history of pityriasis versicolor. This observation could confirm the hypothesis that constitutional factors, e.g. seborrhoea and chemical constitution of sebum, may play a crucial role in temperate climates

  13. Sebaceous gland, hair shaft, and epidermal barrier abnormalities in keratosis pilaris with and without filaggrin deficiency

    DEFF Research Database (Denmark)

    Gruber, Robert; Sugarman, Jeffrey L; Crumrine, Debra;

    2015-01-01

    Although keratosis pilaris (KP) is common, its etiopathogenesis remains unknown. KP is associated clinically with ichthyosis vulgaris and atopic dermatitis and molecular genetically with filaggrin-null mutations. In 20 KP patients and 20 matched controls, we assessed the filaggrin and claudin 1...

  14. Sickle cell anemia in an American white boy of Greek ancestry.

    Science.gov (United States)

    Campbell, J J; Oski, F A

    1977-02-01

    A 7-year-old American white boy of Greek ancestry had sickle cell anemia. The disease in this patient was not accompanied by painful episodes or recognizable hematologic complications, although he did demonstrate considerable delay in skeletal maturation. The patient sought medical attention for a dermatologic problem that was ultimately diagnosed as pityriasis rubra pilaris. To our knowledge, this is the first demonstrated example of sickle cell anemia in a white male described in the United States.

  15. A clinical and histolopathological study of pityriasis lichenoides

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    Nair Pradeep

    2007-01-01

    Full Text Available Background: Pityriasis lichenoides is a papulosquamous disorder of unknown etiology with remissions and exacerbations. Histopathology helps greatly in the diagnosis of this condition. Aim: We studied clinical and histopathological features of pityriasis lichenoides in our patients. Methods: This is a 3-year retrospective and prospective, descriptive study of all patients clinically diagnosed as pityriasis lichenoides and confirmed by histopathology. All patients were studied clinically and histopathologically. Results: There were 51 (30 males and 21 females cases of pityriasis lichenoides in the study period. The maximum number of cases, 14 (27.45% were in their second decade of life. Pityriasis lichenoides chronica was diagnosed in 39 cases (76.47% and pityriasis lichenoides et varioliformis acuta (PLEVA in 12 cases (23.53%. Histopathologically, basal cell vacuolation and perivascular infiltrate were seen in all the cases. Exocytosis was seen in 45.1% of the cases. All the cases of PLEVA showed lymphocytic vasculitis albeit without fibrinoid deposition in the vessel walls. Conclusion: Pityriasis lichenoides is not a rare disorder. and is not a true lymphocytic vasculitis as blood vessel damage and fibrinoid deposition in the blood vessel walls were not seen in this study.

  16. Pityriasis lichenoides chronica presenting with bilateral palmoplantar involvement.

    Science.gov (United States)

    Avshalumova, Lyubov; Richardson, Blakely; Miller, Richard

    2016-05-01

    Pityriasis lichenoides is an uncommon, acquired, idiopathic, self-limiting skin disease that poses a challenge to patients and clinicians to diagnose and treat. Several variants exist including pityriasis lichenoides et varioliformis acuta (PLEVA), pityriasis lichenoides chronica (PLC), and febrile ulcer-onecrotic Mucha-Habermann disease. Precise classification can be difficult due to an overlap of clinical and histologic features. In this case report we describe a patient with a rare presentation of PLC exhibiting bilateral palmoplantar involvement and mimicking psoriasis. We review the literature and discuss the clinical course, pathogenesis, and current treatment modalities of PLC.

  17. Childhood Pityriasis Rosea Inversa without Herald Patch Mimicking Cutaneous Mastocytosis

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    Pelin Ertan

    2010-06-01

    Full Text Available Background:Pityriasis rosea is a self-limited inflammatory condition of the skin that mostly affects young adults. Several less common atypical presentations have been reported. Case Presentation:A 6-year old girl with red-brown maculopapular eruption sized 0, 5-1 cm in diameter localized on neck, trunk and popliteal region visited our general pediatric outpatient clinic. The eruption was wide spread especially on flexural areas. After consulting dermatologist skin biopsy was performed. According to clinical and histopathological findings as inverse (flexural pityriasis rosea was diagnosed. For treatment, systemic antihistamine, topical corticosteroid cream and emollient were applied. The lesions healed in two months. Spontaneous healing of the eruption also confirmed the diagnosis of pityriasis rosea. Conclusion:We present this interesting pediatric case to show and discuss pityriasis rosea, atypical presentations, differential diagnosis and the importance of dermatological examination and importance of dermatologic consultation for pediatric patients with skin eruption.

  18. Childhood Pityriasis rosea inversa without Herald Patch Mimicking Cutaneous Mastocytosis

    Science.gov (United States)

    Ermertcan, Aylin Türel; Özgüven, Aykan; Ertan, Pelin; Bilaç, Cemal; Temiz, Peyker

    2010-01-01

    Background Pityriasis rosea is a self-limited inflammatory condition of the skin that mostly affects young adults. Several less common atypical presentations have been reported. Case Presentation A 6-year old girl with red-brown maculopapular eruption sized 0, 5–1 cm in diameter localized on neck, trunk and popliteal region visited our general pediatric outpatient clinic. The eruption was wide spread especially on flexural areas. After consulting dermatologist skin biopsy was performed. According to clinical and histopathological findings as inverse (flexural) pityriasis rosea was diagnosed. For treatment, systemic antihistamine, topical corticosteroid cream and emollient were applied. The lesions healed in two months. Spontaneous healing of the eruption also confirmed the diagnosis of pityriasis rosea. Conclusion We present this interesting pediatric case to show and discuss pityriasis rosea, atypical presentations, differential diagnosis and the importance of dermatological examination and importance of dermatologic consultation for pediatric patients with skin eruption. PMID:23056712

  19. An Atypical Case of Pityriasis Rosea Gigantea after Influenza Vaccination

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    Dimitrios Papakostas

    2014-04-01

    Full Text Available Pityriasis rosea is a common erythematosquamous eruption, typically presenting along the cleavage lines of the skin. A wide spectrum of atypical manifestations may challenge even the most experienced physician. Here we report a rare case of a suberythrodermic pityriasis rosea with gigantic plaques after an influenza vaccination, and we discuss the possible triggers of atypical manifestations of such a common dermatological disease in the setting of an altered immunity.

  20. Study of role of streptococcal throat infection in pityriasis rosea

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    Parija Madhuri

    2008-01-01

    Full Text Available Background: Pityriasis rosea is a common, acute exanthem of uncertain etiology. The exact cause of pityriasis rosea is not known but various hypotheses have been postulated incriminating infective agents such as viruses, bacteria, spirochete and noninfective etiologies such as atopy and autoimmune causes have also been investigated. Aim: We undertook a study to investigate the role of Streptococcus haemolyticus in the causation of pityriasis rosea and study the levels of C-reactive protein (CRP and ASLO titer in patients with pityriasis rosea. Materials and Methods: The study included 20 patients with pityriasis rosea attending the outpatient dermatology department at JIPMER hospital during the period from June to December 2004. Corresponding number of age- and sex-matched controls were chosen from amongst healthy individuals and patients attending skin OPD with dermatological disorders other than pityriasis rosea. Results: On analyzing the data collected from 20 cases of pityriasis rosea, the average age was found to be 15.3 years and ranged from 5 years to 30 years. The male to female ratio was found to be 1.5:1. The average duration of illness was 14.5 days (median and 29.3 days (mean. CRP was negative in all the cases as well as the controls. ASLO titer was found to be raised in 2 (10% cases, while it remained below the critical value in all the controls. On comparing the cases and controls, the raised ASLO titer in the cases was found to be not statistically significant (p = 0.147. From the throat swab culture, Streptococcus haemolyticus was isolated from only one case and none of the controls. This finding was not statistically significant (p = 0.310. Conclusion: As per the findings of the present study, we arrived at conclusion that there is no association between streptococcus pharyngitis and pityriasis rosea.

  1. An Atypical Case of Pityriasis Rosea Gigantea after Influenza Vaccination

    OpenAIRE

    Dimitrios Papakostas; Stavropoulos, Panagiotis G; Dafni Papafragkaki; Ekaterini Grigoraki; Georgia Avgerinou; Christina Antoniou

    2014-01-01

    Pityriasis rosea is a common erythematosquamous eruption, typically presenting along the cleavage lines of the skin. A wide spectrum of atypical manifestations may challenge even the most experienced physician. Here we report a rare case of a suberythrodermic pityriasis rosea with gigantic plaques after an influenza vaccination, and we discuss the possible triggers of atypical manifestations of such a common dermatological disease in the setting of an altered immunity.

  2. Ketoconazole 2% shampoo in pityriasis versicolor: An open trial

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    Rathi S

    2003-03-01

    Full Text Available Pityriasis versicolor is a common superficial fungal infection caused by a lipophilic yeast. The aim of the study was to evaluate the efficacy of ketoconazole 2% shampoo in the treatment of pityriasis versicolor, for which thirty patients were included. The shampoo was applied daily for 3 days and found to be very effective in clearing the signs and symptoms of the disease. There was no serious adverse effects.

  3. A clinicoepidemiological study of pityriasis rosea in South India.

    Science.gov (United States)

    Ganguly, Satyaki

    2013-01-01

    Pityriasis rosea is an acute self-limiting papulosquamous skin disorder of unknown etiology. Although pityriasis rosea is a common dermatologic disorder, information regarding the epidemiology of the disease in India is limited because of inadequate studies. The incidence and presentation of pityriasis rosea varies from one geographical region to another. The objective was to study the various clinical patterns of the disease and epidemiologic factors influencing its occurrence. A cross-sectional study on the clinicoepidemiologic pattern of pityriasis rosea was conducted. A detailed history of illness regarding onset, evolution, duration, symptoms, systemic features, recurrence, history of contact, and associated factors such as socioeconomic status, history of drug intake, and use of new clothing, along with epidemiologic data, was recorded in the performa. The age of the patients ranged from 3 to 47 (mean 20.32) years. Incidence of pityriasis rosea was highest among patients aged 11 to 20 years followed by those 21 to 30 years. There was a male preponderance. Seasonal variation was not evident. History of using new garments or old garments, unwashed for an extended period was elicited in 23% of cases. The average interval of onset of lesions and presentation to physician was 14.45 days. Pruritus was a common symptom (70%). Of 73 patients, 67 had herald patch. The clinical features of most of the cases were in accordance with the classical pattern of pityriasis rosea.

  4. Hypotrichosis with keratosis pilaris: electrophoretical study of hair fibrous proteins from a patient.

    Science.gov (United States)

    Dekio, S; Nagashima, T; Watanabe, Y; Jidoi, J

    1989-01-01

    S-carboxymethylated (SCM) fibrous proteins from the scalp hair of a patient with hypotrichosis with keratosis pilaris (HTKP) and from that of a normal individual were analyzed using two-dimensional electrophoresis. One SCM fibrous protein component was different electrophoretically in the HTKP patient. It is suggested that the brittleness of the HTKP hair might result from this alteration of the fibrous protein composition of the hair.

  5. Pityriasis versicolor in the pediatric age group

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    Jena Deepak

    2005-01-01

    Full Text Available BACKGROUND: Pityriasis versicolor (PV is a mild chronic infection of the skin caused by Malassezia yeasts. Although it is primarily seen in adults, children are often affected in the tropics . METHODS: Over a period of 2 years, children (up to the age of 14 years who were clinically and mycologically diagnosed as PV were included in the study. The clinical and epidemiological pattern in different age groups was noted. RESULTS: PV in this age group formed about 31% of the total cases of PV; 4.8% cases presented in infancy. The commonest site of involvement was the face in 39.9% of the cases. Most of the cases presented in summer months. CONCLUSIONS: PV is not an uncommon disease among children in the tropics. There is a sudden resurgence of cases in the hot monsoons and even infants are not spared.

  6. Acral pityriasis versicolor – A rare clinical presentation

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    Tasleem Arif

    2015-04-01

    Full Text Available Pityriasis versicolor is a superficial fungal infection of the skin caused by the yeast of the genus Malassezia and presents as hypo or hyper pigmented scaly macules. The most commonly affected sites include upper trunk, upper arms, neck and the abdomen. Lesions confined to the acral parts like hands and feet have rarely been reported. In this article the author reports a 40 year old male who presented with multiple hypo pigmented scaly macules confined to the acral parts (hands and wrist. The acral variant of pityriasis versicolor is considered to be a very rare clinical entity which prompted the author to report this case.

  7. Pityriasis rosea following influenza (H1N1 vaccination

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    Jeng-Feng Chen

    2011-06-01

    Full Text Available Pityriasis rosea is a distinct papulosquamous skin eruption that has been attributed to viral reactivation, certain drug exposures or rarely, vaccination. Herein, we reported a clinicopathlogically typical case of pityriasis rosea that developed after the H1N1 vaccination. With a global H1N1 vaccination program against the pandemic H1N1 influenza, patients should be apprised of the possibility of such rare but benign skin reaction to avoid unnecessary fear. Furthermore, a brief review of the current reported skin adverse events related to the novel H1N1 vaccination in Taiwan is presented here.

  8. Fluconazole in the therapy of Pityriasis versicolor

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    Poljački Mirjana N.

    2005-01-01

    Full Text Available The authors present the results of the systemic application of flukonazole in therapy of Pityriasis versicolor. It was arranged for the total number of 38 patients, 18 females and 20 males. The diagnosis of diseases was established on the base of the clinical examination, the native mycological examination and by the using of Wood lamps. The therapy was passed by the using of 300 mg flukonazole in a single dose, once weekly, during two weeks. The following period amounted to one week after the passed therapy. The therapeutic efficacy was assessed with regard to the clinical and mycological healing. The clinical efficacy was assessed semiquantitative on the base of increasing of the percentage rates of the total score of disease that was computed by collecting of the numeric values for every clinical argument typical for the disease, and the mycological efficacy on the base of the mycological findings and the fluorescence finding after lightening with the Wood's lamp. The controlling examinations were performed on day 0, 14 and 22. The results of investigations have shown that the complete clinical healing was achieved after two weeks of therapy in 94,74%, and the mycological healing in 92,11% patients. The rate of the mycological healing was evaluated after 1 week of following period equal to the rate of the clinical healing and it was also 94,74%. The undesirable effects of the drug applications weren't by any patient.

  9. Pitiríase Versicolor Pityriasis Versicolor

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    Josenildo Rodrigues de Oliveira

    2002-10-01

    Full Text Available A expressão pitiríase versicolor define uma infecção fúngica superficial caracterizada por alterações na pigmentação cutânea. O distúrbio de pigmentação é devido à colonização do estrato córneo por um fungo dimórfico, lipofílico, encontrado na flora normal da pele, conhecido como Malassezia furfur. Trata-se de doença prevalente nos trópicos, mas também comum em climas temperados. Há vários tratamentos disponíveis com taxas elevadas de cura, porém as recorrências são freqüentes.Pityriasis versicolor is a superficial fungal infection characterized by changes in skin pigment due to colonization of the stratum corneum by a dimorphic lipophilic fungus of the normal flora of the skin, known as Malassezia furfur. This disease is most prevalent in the tropics, but is also common in temperate climates. Treatment is available and cure rates are high, although recurrence is common.

  10. Narrowband UVB phototherapy in pityriasis rosea

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    Vijayeeta Jairath

    2015-01-01

    Full Text Available Objective: Pityriasis rosea (PR is an acute self-limiting disease. Despite vigorous efforts by generations of researchers since nearly 150 years, present treatment modalities for PR are not very gratifying. Ultraviolet radiation has been recommended in PR, although only a few studies validate this proposal. This study was conducted to explore the therapeutic effect of NBUVB on the symptoms, course, and severity of PR. Materials and Methods: This study involved a hundred patients who were randomly divided into two groups, using computer-generated randomization chart. Group A underwent treatment with fixed dose NBUVB of 250 mJ/cm2 three times (nonconsecutive a week for 4 weeks. Group B formed the placebo group who did not receive any treatment. The two groups were compared with each other for the intensity of pruritis, course and duration of disease, and PR severity score (PRSS. Results: The t values of improvement in PRSS score in Group A (t = 12.796 were higher as compared with that in Group B (t = 10.066. Similarly, the t value of the pruritus scale in Group A (t = 7.758 was higher than Group B (t = 5.754 indicating the symptomatic improvement in itching. Conclusion: Fixed-dose NBUVB phototherapy resulted in marked improvement in the severity and symptoms of the disease as quantitatively assessed by PRSS.

  11. Disruption of barrier function in dermatophytosis and pityriasis versicolor.

    Science.gov (United States)

    Lee, Weon Ju; Kim, Jun Young; Song, Chang Hyun; Jung, Hong Dae; Lee, Su Hyun; Lee, Seok-Jong; Kim, Do Won

    2011-11-01

    Dermatophytes have the ability to form molecular attachments to keratin and use it as a source of nutrients, colonizing keratinized tissues, including the stratum corneum of the skin. Malassezia species also affect the stratum corneum of the skin. Therefore, dermatophytosis and pityriasis versicolor of the skin are thought to be important factors of profound changes in skin barrier structure and function. We aimed to describe the changes in transepidermal water loss (TEWL), stratum corneum hydration, and skin pH in the lesions of the dermatophytosis and pityriasis versicolor. Thirty-six patients with dermatophytosis (14 with tinea cruris, 13 with tinea corporis and nine with tinea pedis or tinea manus) and 11 patients with pityriasis versicolor were included in this study. TEWL, stratum corneum conductance and skin pH were determined by biophysical methods to examine whether our patients exhibited changes in barrier function. Dermatophytosis and pityriasis versicolor except tinea pedis and tinea manus showed highly significant increase in TEWL compared with adjacent infection-free skin. Hydration was significantly reduced in lesional skin compared with adjacent infection-free skin. From this study, infections with dermatophytes and Malassezia species on the body can alter biophysical properties of the skin, especially the function of stratum corneum as a barrier to water loss. On the contrary, infections with dermatophytes on the palms and soles little affect the barrier function of the skin. © 2011 Japanese Dermatological Association.

  12. Atypical pityriasis rosea: clinical evaluation of 27 patients.

    Science.gov (United States)

    Kilinc, Fadime; Akbas, Ayse; Sener, Sertac; Aktaş, Akın

    2017-06-01

    Pityriasis rosea (PR) is a common, acute, self-limiting inflammatory skin disease. It can easily be recognized with its typical clinical presentation. However, unusual clinic presentations can cause difficulty in diagnosis. Up to now, not many atypical forms are reported. To determine the clinical characteristics of patients with atypical pityriasis rosea. A total of 27 cases, diagnosed as atypical PR by clinical and/or histopathological examination and applied to the outpatient clinic of dermatology department between the years 2007 and 2015 were analyzed retrospectively. The ages of patients ranged from 2 to 59 years. Of these patients, 15 (55.6%) were male and 12 (44.4%) were female. The male-to-female ratio was 5-4. Five patients had papular, four patients had purpuric, three patients had vesicular, two patients had follicular, one patient had erythema multiforme-like and one patient had eczematous drug-induced atypical form of pityriasis rosea. There were 12 cases of localized, two cases of segmental pityriasis rosea. Four of the localized forms also had atypical morphology. Histopathological evaluation was required for diagnosis in 12 (44.4%) patients. PR can appear in many different uncommon forms. Localization and skin rush can be misleading and diagnosis can be compelling.

  13. [Pityriasis versicolor in Greece and its predisposition factors].

    Science.gov (United States)

    Parisis, N; Stratigos, J; Marcelou-Kinti, U; Capetanakis, J

    1977-11-01

    The age and seasonal incidence of 2610 patients with pityriasis versicolor in Greece were studied. Determination of the pH of Na and K ions of the sweat and the microbiol flora of the skin of pityriasis versicolor patients was undertaken. Besides these the effectiveness of a 1% selenium disulfid suspension was tested. The results indicate that the age groups of 20-29 and 30-30 years are mostly affected by the disease. A high incidence of the skin manifestation was noted during the summer and fall months. A difference of the pH of the sweat between pityriasis versicolor and healthy controls was observed, but no difference was found in the Na and K ions of the sweat among these two groups. Neither did the microbial flora from the skin lesions of patients and from corresponding sites of controls show any difference. The high relapse in this experiment indicates the relative ineffectiveness of selenium disulfid preparations when used as a 1% suspension in the treatment of pityriasis versicolor.

  14. Influence of systemic corticotherapy on the triggering of pityriasis versicolor.

    Science.gov (United States)

    da Fraga, Clarissa Matarangas Moreira; de Cássia Birschiner, Rita; Naseri, Alice Pignaton; Diniz, Lucia Martins

    2014-09-01

    Pityriasis versicolor is a frequent mycosis and the use of systemic corticotherapy is one of its predisposing factors. This is an observational, cross-sectional, analytical and comparative study, conducted from January 2012 to January 2013 in the following outpatient clinics: Dermatology Service, Cassiano Antonio Moraes Hospital (HUCAM), Vitória, ES, Brazil; Nephrology Service, HUCAM; and Leprosy Department, Maruípe Health Unit, Vitória, ES, Brazil. Patients, undergoing long-term systemic corticotherapy (or not), were assessed with respect to the presence of pityriasis versicolor. If there was mycosis, a direct mycological examination would be carried out. The spss 17.0 software was used for the statistical analysis. From the total of 100 patients, nine had pityriasis versicolor, being eight from the corticotherapy group and one from the group with no use of corticosteroids. Regarding the patients with mycosis, the prevalent age ranged from 20 to 39 years, with six patients; six were women; seven mixed race; eight were undergoing long-term systemic corticotherapy; seven were taking low-dose systemic corticosteroids; four had leucocytosis; five had normal total cholesterol and triglycerides; and four had normal glycaemia. There was increased frequency of pityriasis versicolor in the group undergoing systemic corticotherapy with statistical significance, corroborating the only study on the topic (1962).

  15. Pityriasis versicolor: avoiding pitfalls in disease diagnosis and therapy.

    Science.gov (United States)

    Rivard, Shayna C

    2013-08-01

    Pityriasis versicolor is common among young active duty members with overactive sweat glands working in humid environments and results in pigmentary changes that can be profound in those with darker skin. This article addresses several issues related to making the correct diagnosis and providing appropriate treatment, as well as the specific challenges military providers may face in these cases.

  16. Pityriasis Lichenoides Chronica Associated with Herpes Simplex Virus Type 2

    Directory of Open Access Journals (Sweden)

    Antonio Javier González Rodríguez

    2012-01-01

    Full Text Available Introduction. Pityriasis lichenoides is a rare, acquired spectrum of skin conditions of an unknown etiology. Case Report. A 28-year-old man presented with recurrent outbreaks of herpes simplex virus associated with the onset of red-to-brown maculopapules located predominantly in trunk in each recurrence. Positive serologies to herpes simplex virus type 2 were detected. Histopathological examination of one of the lesions was consistent with a diagnosis of pityriasis lichenoides chronica. Discussion. Pityriasis lichenoides is a rare cutaneous entity of an unknown cause which includes different clinical presentations. A number of infectious agents have been implicated based on the clustering of multiple outbreaks and elevated serum titers to specific pathogens (human immunodeficiency virus, cytomegalovirus, Epstein-Barr virus, Toxoplasma gondii, and herpes simplex virus. In our patient, resolution of cutaneous lesions coincided with the administration of antiviral drugs and clinical improvement in each genital herpes recurrence. In conclusion, we report a case in which cutaneous lesions of pityriasis lichenoides chronica and a herpes simplex virus-type 2-mediated disease have evolved concomitantly.

  17. Predisposing factors on the surface of the skin in persons with pityriasis versicolor.

    Science.gov (United States)

    Gloor, M; Kümpel, D; Friederich, H C

    1975-12-31

    This is a report on biochemical and physiological examinations carried out on 20 test persons who in the last 2 years had contacted and completely recovered from pityriasis versicolor and on 25 control persons of corresponding age and sex. The tests on the skin surface of the patients with pityriasis versicolor show, when compared with the corresponding control group, the following significant results: 1. Significantly more amino acids could be extracted from the skin of the pityriasis versicolor patients than from the skin of the control persons. 2. A significantly shorter alkali neutralisation time was to be found in the pityriasis versicolor patients than in the control persons. 3. The degree of water spreading on the skin was found to be significantly reduced in the pityriasis versicolor patients when compared with the control persons. It is probable that these results point to important predisposing factors for pityriasis versicolor.

  18. Tissue immunostaining for factor XIIIa in dermal dendrocytes of pityriasis alba skin lesions

    OpenAIRE

    Carneiro, Francisca Regina Oliveira; Amaral,Gabriela Borborema do; Mendes,Maiana Darwich; Quaresma,Juarez Antônio Simões

    2014-01-01

    BACKGROUND: Pityriasis alba affects 1% of the world population and about 9.9% of the children in Brazil. However, its etiology remains uncertain. OBJECTIVE: The objective of the present study was to evaluate the immunoexpression of factor XIIIa in dermal dendrocytes of skin lesions of pityriasis alba. METHOD: Twenty patients with pityriasis alba and 20 patients with atopic dermatitis underwent biopsy. The dermal dendrocytes marked by factor XIIIa were counted by means of immunohistochemic...

  19. Clinicomycological profile of pityriasis versicolor in Assam

    Directory of Open Access Journals (Sweden)

    Ajanta Sharma

    2016-01-01

    Full Text Available Background: Geographical variation in the distribution of Malassezia species associated with pityriasis versicolor (PV has led to the necessity of studying epidemiological, mycological, and clinical characteristics of PV. Aims: To study the epidemiological, mycological, and clinical characteristics of PV in a tertiary care hospital. Settings and Design: The study was carried out with a cross-sectional design. Materials and Methods: Two hundred and sixty-two consecutive PV patients were subjected to detailed history, clinical examination, and investigations. Skin scrapings were processed by direct microscopy and culture. Isolates were identified by phenotypic characteristics and polymerase chain reaction-restriction fragment length polymorphism. Association of Malassezia species with clinical and epidemiological characteristics was studied. Statistical analysis of the data was done using statistical software. Results: Maximum number of PV cases (33.9% belonged to the age group of 21–30 years with a male preponderance. 61.4% of the patients had a sedentary lifestyle, 70.2% showed the gradual onset of the disease, 51.1% presented with pruritus and in 66.4% of the patients symptoms were continuous. Most commonly involved body site was neck (27.8%, 77.09% of the lesions were bilaterally asymmetrical, 87.4% were macular, and 89.3% were hypopigmented. Malassezia furfur (77.3% was the predominant species. Sedentary lifestyle (61.4% and increased sweating (48% were the most commonly associated predisposing factors. Conclusion: PV is more common in males. Distribution of Malassezia species varies significantly from those reported in other parts of India. M. furfur was the most common species responsible for PV in our region. Hence, further studies are required to evaluate the exact cause of this variation.

  20. A case of Pityriasis rosea concurrent with the novel influenza A (H1N1) infection.

    Science.gov (United States)

    Mubki, Thamer F; Bin Dayel, Salaman A; Kadry, Razan

    2011-01-01

    Pityriasis rosea is a common skin disease with a self-limiting course. Multiple etiologies including viruses, bacteria, and fungi have been investigated in an attempt to confirm a casual association. Pityriasis rosea has not been associated with influenza virus, but has been associated with herpes simplex virus types 6 and 7. We encountered a case of a proven pandemic H1N1 infection associated with a clincopathological diagnosis of pityriasis rosea. We conclude that influenza A (H1N1) virus could either be a primary cause of pityriasis rosea or a trigger for reactivation of other viral causes. © 2011 Wiley Periodicals, Inc.

  1. ORIGINAL ARTICLE : Skin Characteristics in Patients with Pityriasis Versicolor Using Non-Invasive Method, MPA5

    National Research Council Canada - National Science Library

    Hyun Jung Park; ; Yang Won Lee; Yong Beom Choe; Kyu Joong Ahn

    2012-01-01

    Background: Skin pigmentary changes of pityriasis versicolor may occur as either hyperpigmented or hypopigmented lesions, depending on the outcome of interactions between Malassezia yeasts and the skin...

  2. Pityriasis rosea like drug rash - a need to identify the disease in childhood.

    Science.gov (United States)

    Panda, Maitreyee; Patro, Nibedita; Jena, Monalisa; Dash, Mrutunjay; Mishra, Swati

    2014-08-01

    Pityriasis rosea is a common dermatosis named by Gibert in 1860. It is an acute self limiting papulosquamous disease, probably infective in origin affecting healthy adolescents and young adults. It is characterized by distinctive skin eruptions and minimal constitutional symptoms. Drug induced pityriasis rosea tend to occur in older generation and resolution seen only after withdrawal of the offending drug. We report a case of 12-year-old boy with erythematous papules distributed over trunk and proximal arms after nimesulide therapy consistent with a clinical diagnosis of atypical pityriasis rosea. The relation of drug and development of pityriasis rosea is confirmed by dechallenge test of the suspected drug.

  3. Pityriasis Rosea Like Drug Rash – A Need to Identify the Disease in Childhood

    Science.gov (United States)

    Patro, Nibedita; Jena, Monalisa; Dash, Mrutunjay; Mishra, Swati

    2014-01-01

    Pityriasis rosea is a common dermatosis named by Gibert in 1860. It is an acute self limiting papulosquamous disease, probably infective in origin affecting healthy adolescents and young adults. It is characterized by distinctive skin eruptions and minimal constitutional symptoms. Drug induced pityriasis rosea tend to occur in older generation and resolution seen only after withdrawal of the offending drug. We report a case of 12-year-old boy with erythematous papules distributed over trunk and proximal arms after nimesulide therapy consistent with a clinical diagnosis of atypical pityriasis rosea. The relation of drug and development of pityriasis rosea is confirmed by dechallenge test of the suspected drug. PMID:25302254

  4. Notes on Musa rubra Kurz (Musaceae and reduction of M. laterita Cheesman as conspecific

    Directory of Open Access Journals (Sweden)

    Alfred Joe

    2016-03-01

    Full Text Available Notes on taxonomic identity and history of M. rubra is provided and lectotype is designated here. Detailed description, photographs and illustration are provided for easy identification. M. laterita is treated as conspecific to M. rubra.

  5. Gestational Pityriasis Rosea: Suggestions for Approaching Affected Pregnant Women.

    Science.gov (United States)

    Monastirli, Alexandra; Pasmatzi, Efstathia; Badavanis, George; Tsambaos, Dionysios

    2016-12-01

    Dear Editor, Pityriasis rosea is a common, acute, and self-limiting dermatosis, which is associated with the endogenous systemic reactivation of human herpesvirus (HHV)-6 and/or HHV-7 (1). It predominantly affects individuals of both sexes in their second or third decade of life and is clinically characterized by the occurrence of an initial erythematosquamous plaque followed by the appearance of disseminated similar but smaller lesions one or two weeks later. Several patients develop systemic symptoms such as nausea, anorexia, malaise, headache, fever, arthralgia, and lymphadenopathy that may precede or accompany the eruption; the latter follows the cleavage lines of the trunk creating the configuration of a Christmas tree and spontaneously resolves within 4 to 8 weeks. Mainly based on the nature of the underlying viral reactivation, pityriasis rosea is classified into five different forms (2): 1) Classic and 2) Relapsing (characterized by sporadic and relapsing HHV-6/7 systemic reactivation, respectively), 3) Persistent (persistence of HHV-6/7 viremia), 4) Pediatric (longer activity of HHV-6/7 infection; recent primary infection) and 5) Gestational (HHV-6/7 reactivation and possible intrauterine transmission). Clearly, the inevitable impairment of immune response in pregnancy favors viral reactivation and possibly also the intrauterine transmission of HHV-6/7. Indeed, it is well known and documented that pityriasis rosea more frequently occurs in pregnant women (18%) as compared to the general population (6%) (3). However, the literature concerning the possible effect of pityriasis rosea on the outcome of pregnancy is surprisingly sparse. Only an Italian group, Drago et al (4,5), has systematically investigated the impact of this disorder on pregnant women. They found that 22 out of 61 women (36%) who developed pityriasis rosea during pregnancy had unfavorable outcomes, whereas 8 others miscarried (13%). None of the latter had any risk factors, other than

  6. Nomenclature of drug-induced pityriasis rosea-like rashes

    Directory of Open Access Journals (Sweden)

    Chuh AAT

    2015-10-01

    Full Text Available Antonio AT Chuh1Prince of Wales Hospital, Hospital Authority, 2The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong KongI read with admiration an article published in your prestigious journal on the rare adverse effects of clozapine (CLZ.1I write to address a specific issue in this article. In the second paragraph of the section “Dermatological adverse effects”, it was stated that a 54-year-old patient with schizophrenia treated for 28 days with CLZ developed a generalized rash compatible with pityriasis rosea (skin rash that usually begins as one large circular or oval spot on your chest, abdomen, or back.I wish to point out certain problems for coining pityriasis rosea (PR as the diagnostic label in the patient concerned.View original paper by De Fazio and colleagues.

  7. Pityriasis Versicolor on Penile Shaft in a Renal Transplant Recipient

    Science.gov (United States)

    Ryu, Han-Won; Cho, Jae-We

    2012-01-01

    Pityriasis versicolor is a superficial infection of the stratum corneum, which is caused by the Malassezia species. Tge Malassezia species consist of 12 subspecies, including M. furfur, M. pachydermatis, M. symphodialis and M. globasa. The Malassezia species are classified as a normal flora, particularly in the sebum rich areas of the skin, and they convert from saprophytic yeast to parasitic mycelial morpholgic form to cause clinical disease. But majorities of their distributions are in the upper back, the neck, the thighs, and the forearm, and not in the penis. It is well known that the renal transplant patients, who take immunosuppressive agents, have impairment in the protective cell mediated immunity. Thus, they are more susceptible to infectious diseases, such as a fungal infection. Therefore, clinical manifestations show higher incidence of disease, but they mostly occur in an expected distribution. We here report a case of pityriasis versicolor in a renal transplant recipient on penile shaft, which is an unusual area. PMID:22879720

  8. Pityriasis rosea in 12-months-old infant

    Directory of Open Access Journals (Sweden)

    Piotr Brzezinski

    2012-04-01

    Full Text Available Pityriasis Rosea (PR is a self-limiting papulo-squamous disorder characterized in its typical form by sudden onset of a larger scaly plaque (herald plaque, followed by multiple, bilateral smaller scaly lesions of oval or round shape which follow Langer’s lines of cleavage on the trunk and proximal parts of extremities.Currently accepted hypothesis that the cause of this disease are human herpesvirus: HHV-6 and HHV-7.Presented case of 12-months-old infant with the image of a pityriasis rosea.PR is a common skin condition seen in children and adults. PR is rarely diagnosed in infants. It is important to distinguish it from other childhood exanthems.

  9. Pityriasis versicolor on penile shaft in a renal transplant recipient.

    Science.gov (United States)

    Ryu, Han-Won; Cho, Jae-We; Lee, Kyu-Suk

    2012-08-01

    Pityriasis versicolor is a superficial infection of the stratum corneum, which is caused by the Malassezia species. Tge Malassezia species consist of 12 subspecies, including M. furfur, M. pachydermatis, M. symphodialis and M. globasa. The Malassezia species are classified as a normal flora, particularly in the sebum rich areas of the skin, and they convert from saprophytic yeast to parasitic mycelial morpholgic form to cause clinical disease. But majorities of their distributions are in the upper back, the neck, the thighs, and the forearm, and not in the penis. It is well known that the renal transplant patients, who take immunosuppressive agents, have impairment in the protective cell mediated immunity. Thus, they are more susceptible to infectious diseases, such as a fungal infection. Therefore, clinical manifestations show higher incidence of disease, but they mostly occur in an expected distribution. We here report a case of pityriasis versicolor in a renal transplant recipient on penile shaft, which is an unusual area.

  10. Depigmented lesions of pityriasis versicolor: A diagnostic dilemma with review of literature

    OpenAIRE

    Tejinder Kaur; Daljit Singh; Suresh K Malhotra; Arashbir Kaur

    2017-01-01

    Pityriasis versicolor is a superficial mycosis affecting the skin. It is caused by malassezia species of fungi. Common sites of involvement are chest, neck and shoulders. We report a rare case of pityriasis versicolor affecting both arms and dorsum of both hands but sparing the commonly involved sites and masquerading vitiligo.

  11. Depigmented lesions of pityriasis versicolor: A diagnostic dilemma with review of literature

    Directory of Open Access Journals (Sweden)

    Tejinder Kaur

    2017-04-01

    Full Text Available Pityriasis versicolor is a superficial mycosis affecting the skin. It is caused by malassezia species of fungi. Common sites of involvement are chest, neck and shoulders. We report a rare case of pityriasis versicolor affecting both arms and dorsum of both hands but sparing the commonly involved sites and masquerading vitiligo.

  12. Follicular pityriasis versicolor-Rare variant of a common dermatological disease

    OpenAIRE

    Tasleem Arif; Shagufta Rather

    2015-01-01

    Pityriasis versicolor is a superficial fungal infection of the skin caused by yeast of the genus Malassezia. It is characterized by hypopigmented or hyperpigmented macules and patches usually involving the trunk [1]. The variants of pityriasis versicolor include hypochromic, hyperchromic, combination of hypo-hyperchromic, erythematous, circinate, atrophic and acral [2-4].

  13. Follicular pityriasis versicolor-Rare variant of a common dermatological disease

    Directory of Open Access Journals (Sweden)

    Tasleem Arif

    2015-01-01

    Full Text Available Pityriasis versicolor is a superficial fungal infection of the skin caused by yeast of the genus Malassezia. It is characterized by hypopigmented or hyperpigmented macules and patches usually involving the trunk [1]. The variants of pityriasis versicolor include hypochromic, hyperchromic, combination of hypo-hyperchromic, erythematous, circinate, atrophic and acral [2-4].

  14. Comparative histopathology of Pityriasis versicolor and Pityrosporum folliculitis

    Directory of Open Access Journals (Sweden)

    Mittal R

    1992-01-01

    Full Text Available Twenty five cases each of pityriasis versicolor (PV and pityrosporum folliculitis (PF were selected for this study. Histopathologically in PV, spores and hyphae in spaghetti and meatball appearance in stratum corneum, and perivascular mononuclear infiltrate were seen. In PF, spores were inside the dilated hair follicles filled with keratin, perifollicular and perivascular mononuclear infiltration were seen. Basket weave hyperkeratosis, edema and disruption of collagen were seen in 88% cases of PF and have not been reported earlier.

  15. Childhood Pityriasis rosea inversa without Herald Patch Mimicking Cutaneous Mastocytosis

    OpenAIRE

    Pelin Ertan; Aykan Özgüven; Aylin Türel Ermertcan; Cemal Bilaç; Peyker Temiz

    2010-01-01

    Background:Pityriasis rosea is a self-limited inflammatory condition of the skin that mostly affects young adults. Several less common atypical presentations have been reported. Case Presentation:A 6-year old girl with red-brown maculopapular eruption sized 0, 5-1 cm in diameter localized on neck, trunk and popliteal region visited our general pediatric outpatient clinic. The eruption was wide spread especially on flexural areas. After consulting dermatologist skin biopsy was performed. Accor...

  16. Extrinsic allergic alveolitis after exposure to the yeast Rhodotorula rubra.

    Science.gov (United States)

    Siersted, H C; Gravesen, S

    1993-05-01

    A case of extrinsic allergic alveolitis following exposure to the red yeast Rhodotorula rubra is reported--to our knowledge, for the first time. Extensive growth of the yeast in the patient's environment was demonstrated, explaining an elevated titer of Rhodotorula-specific precipitating antibodies in his serum. A bronchial provocation test confirmed the diagnosis.

  17. In vitro propagation of northern red oak (Quercus rubra L.)

    Science.gov (United States)

    G. Vengadesan; Paula M. Pijut

    2009-01-01

    In vitro propagation of northern red oak (Quercus rubra) shoots was successful from cotyledonary node explants excised from 8-wk-old in vitro grown seedlings. Initially, four shoots per explant were obtained on Murashige and Skoog (MS) medium supplemented with 4.4 µM 6-benzylaminopurine (BA), 0.45 ...

  18. [Myerson nevus as a primary patch of Gibert pityriasis rosea. A case report].

    Science.gov (United States)

    Hofer, T

    2002-05-01

    There are only few articles in literature which discuss the association between Meyerson's naevi and Pityriasis rosea. And when so, the discussion is done in a controversial way. Here an 18 year old man is presented who visits the outpatient clinic. He has a ten day history of a solitary Meyerson's naevus on his back. Over the next three weeks this naevus will develop to the typical herold patch followed by the classical exantheme of Pityriasis rosea. Halo dermatitis associated with Pityriasis rosea don't represent Meyerson's naevi. But they reflect the rare "nevocentric" property of a not so rare dermatose.

  19. Localised pityriasis rosea-like eruption during radiotherapy. Report of 2 cases.

    Science.gov (United States)

    Moloney, Gary R; Goh, Michelle S Y; Mitchell, Catherine; McCormack, Chris J

    2015-11-01

    Pityriasis rosea is a common skin condition that presents acutely with asymptomatic, scaly and oval plaques, usually in a well-recognised distribution over the trunk. Two men developed ovoid, scaly and annular lesions limited to the radiotherapy field during treatment for pelvic malignancies and without a preceding herald patch. Other causes of the eruption were excluded on clinical and pathological grounds and the histopathological features were consistent with a pityriasis rosea-like eruption. In both cases the lesions resolved spontaneously by 8 weeks. These are the first reported cases of a localised pityriasis rosea-like eruption arising during radiotherapy. © 2014 The Australasian College of Dermatologists.

  20. Identification of Malassezia yeast species isolated from patients with pityriasis versicolor.

    Science.gov (United States)

    Petry, Vanessa; Tanhausen, Fernanda; Weiss, Luciana; Milan, Thais; Mezzari, Adelina; Weber, Magda Blessmann

    2011-01-01

    Pityriasis versicolor (PV) is a disease with worldwide distribution. Twelve different species of Malassezia yeast have been described. The objective of this study was to determine which species of Malassezia are more prevalent in patients with pityriasis versicolor. Samples were collected by scraping the lesions of 87 patients with a clinical suspicion of pityriasis versicolor. The samples were then submitted to fungal microscopy and culture to identify the species. The species found were: Malassezia sympodialis (30%), Malassezia furfur (25.7%), Malassezia globosa (22.7%), Malassezia restricta (12.1%), Malassezia obtusa (7.6%) and Malassezia slooffiae (1.5%).

  1. Pityriasis rosea with erythema multiforme - like lesions: An observational analysis

    Directory of Open Access Journals (Sweden)

    Vineet Relhan

    2013-01-01

    Full Text Available Pityriasis rosea (PR is an acute or subacute inflammatory skin disease characterized by erythematous papulosquamous eruptions localized on the trunk and arms. The eruptions are self-limiting and usually disappear gradually in 2-10 weeks, without any treatment. Typical PR is much easier to diagnose than the rare atypical forms. There is a passing mention of PR with erythema multiforme-like lesions in the literature, but no extensive case series have been published till date. We present a series of five patients for whom we believe atypical PR is the likely diagnosis.

  2. Pityriasis rosea-like eruptions due to mustard oil application

    Directory of Open Access Journals (Sweden)

    Zawar Vijay

    2005-01-01

    Full Text Available A young man employed in a construction company, presented with cutaneous lesions clinically simulating pityriasis rosea. Satisfactory and complete response to corticosteroids and antihistamines was followed by recurrence. Multiple recurrences within a short span of time arose a suspicion of alternative diagnosis. Site visit helped us to rule out occupational contact dermatitis. Further history taking revealed that he was recently using mustard oil for body massage. Subsequent patch testing confirmed contact hypersensitivity to mustard oil. Avoidance of the contact with mustard oil arrested appearance of further skin lesions. We stress the importance of taking a good history in clinical practice in disclosing a possible contactant.

  3. Fractional Carbon Dioxide Laser for Keratosis Pilaris: A Single-Blind, Randomized, Comparative Study

    Directory of Open Access Journals (Sweden)

    Vasanop Vachiramon

    2016-01-01

    Full Text Available Objective. Keratosis pilaris (KP is a common condition which can frequently be cosmetically disturbing. Topical treatments can be used with limited efficacy. The objective of this study is to evaluate the effectiveness and safety of fractional carbon dioxide (CO2 laser for the treatment of KP. Patients and Methods. A prospective, randomized, single-blinded, intraindividual comparative study was conducted on adult patients with KP. A single session of fractional CO2 laser was performed to one side of arm whereas the contralateral side served as control. Patients were scheduled for follow-up at 4 and 12 weeks after treatment. Clinical improvement was graded subjectively by blinded dermatologists. Patients rated treatment satisfaction at the end of the study. Results. Twenty patients completed the study. All patients stated that the laser treatment improved KP lesions. At 12-week follow-up, 30% of lesions on the laser-treated side had moderate to good improvement according to physicians’ global assessment (p=0.02. Keratotic papules and hyperpigmentation appeared to respond better than the erythematous component. Four patients with Fitzpatrick skin type V developed transient pigmentary alteration. Conclusions. Fractional CO2 laser treatment may be offered to patients with KP. Dark-skinned patients should be treated with special caution.

  4. Competition between Festuca rubra L. and F. pratensis Huds. in natural conditions

    Directory of Open Access Journals (Sweden)

    Maria Widera

    2014-02-01

    Full Text Available Analysis of the edaphic conditions and properties of pure and cenopopulations of Festuca rubra and Festuca pratensis allowed to establish the competitivity of these two species on 4 different lithological substrates in the Sudetes Foothills. A model of competition between F. rubra and F. pratensis was constructed on the basis of the biomass of their populations. On a substrate of porphyry, sand and granite F. rubra prevails in competition while on basalt F. pratensi is preponderant.

  5. Evaluation of various therapeutic measures in striae rubra

    Directory of Open Access Journals (Sweden)

    Umesh Karsandas Karia

    2016-01-01

    Full Text Available Background: Striae are linear atrophic depressions that form in areas of dermal damage in the skin. As on date, no consensus or protocol exists for the treatment of stria rubra. Topical retinoids, chemical peels, microdermabrasion, radiofrequency, photothermolysis, intense pulsed light and lasers are some of the modalities used. Aims and Objective: To compare the efficacy of various therapeutic modalities in striae rubra. Methods: This prospective cohort study comprised of a total of fifty patients from August-2012 to October-2013 in a tertiary care center in Western India, Gujarat having striae rubra. They were randomly divided into five groups of ten patients each. Patients were evaluated on the basis of visual assessment, both by doctor as well as the patient. Group I was given topical tretinoin (0.1% w/w gel applied once at night, Group II-microdermabrasion (MDA combined with trichloroacetic acid (TCA (30% peel, Group III-mesotherapy, Group IV-Q-switched Nd: YAG laser, and Group V-combination treatment of microdermabrasion, salicylic acid peel and retinol (yellow peel. Patients were treated at an interval of 15 days for 2 months and then at monthly intervals. Objective assessment was done at 2nd month, 6th month, and at the end of 1st year. Results: Patients in Group I treated with topical tretinoin showed the least response with 80% (8 of them showing minimal clinical improvement (0–25% as compared to patients in Group V in which 60% (6 patients showed moderate clinical improvement (50–75%. While majority of the patients in Group II, III, and IV showed mild clinical improvement (25–50%. Conclusions: Striae rubra is a common cause of concern for adolescent population. Combination treatment with microdermabrasion, salicylic acid and retinol yellow peel gave superior results as compared to other therapeutic options. Mild to moderate improvement was seen with Nd: YAG laser, mesotherapy and MDA + TCA whereas minimal improvement were seen

  6. Tissue immunostaining for factor XIIIa in dermal dendrocytes of pityriasis alba skin lesions

    National Research Council Canada - National Science Library

    Carneiro, Francisca Regina Oliveira; Amaral, Gabriela Borborema do; Mendes, Maiana Darwich; Quaresma, Juarez Antônio Simões

    2014-01-01

    .... However, its etiology remains uncertain. OBJECTIVE: The objective of the present study was to evaluate the immunoexpression of factor XIIIa in dermal dendrocytes of skin lesions of pityriasis alba. METHOD...

  7. Pityriasis versicolor: an update on pharmacological treatment options.

    Science.gov (United States)

    Gupta, Aditya K; Lyons, Danika C A

    2014-08-01

    Pityriasis versicolor (PV) is a superficial fungal infection caused by Malassezia species; a yeast that naturally colonizes on the skins surface. High efficacy rates are generally obtained with both topical and systemic treatments. However, recurrence rates following successful treatment remain high and there are no dosage guidelines available for administration of systemic antifungal agents that carry risks of adverse events. This review focused on providing an overview of existing treatments for PV and an introduction to new treatments. A literature search was conducted using the search strategy, pityriasis versicolor OR tinea versicolor. Over the past decade, few new treatments have been introduced, but the efficacy and the dosing regimens of existing treatments have been systematically reviewed. The results of these reviews are discussed. Existing topical and systemic agents are both effective treatments against PV. Previous dosage recommendations for systemic agents have been modified based on recent evidence elucidated in systematic reviews. However, the absence of standardized collection and reporting practices in clinical trials precludes any conclusions to be drawn regarding the efficacy and safety of topical and systemic agents in comparison or in concert with each other.

  8. Pityriasis alba revisited: perspectives on an enigmatic disorder of childhood.

    Science.gov (United States)

    Jadotte, Yuri T; Janniger, Camila K

    2011-02-01

    Pityriasis alba (PA) is a localized hypopigmented disorder of childhood with many existing clinical variants. It is more often detected in individuals with a darker complexion but may occur in individuals of all skin types. Atopy, xerosis, and mineral deficiencies are potential risk factors. Sun exposure exacerbates the contrast between normal and lesional skin, making lesions more visible and patients more likely to seek medical attention. Poor cutaneous hydration appears to be a common theme for most risk factors and may help elucidate the pathogenesis of this disorder. The end result of this mechanism is inappropriate melanosis manifesting as hypopigmentation. It must be differentiated from other disorders of hypopigmentation, such as pityriasis versicolor alba, vitiligo, nevus depigmentosus, and nevus anemicus. Alleviation of the various risk factors via patient education on proper skin care and hygiene, use of lubricants and emollients, topical corticosteroid therapy in the presence of inflammation, and the novel administration of topical anti-inflammatory drugs such as calcineurin inhibitors can play a crucial role in promoting remission or resolution.

  9. Skin Characteristics in Patients with Pityriasis Versicolor Using Non-Invasive Method, MPA5

    OpenAIRE

    Park, Hyun Jung; Lee, Yang Won; Choe, Yong Beom; Ahn, Kyu Joong

    2012-01-01

    Background Skin pigmentary changes of pityriasis versicolor may occur as either hyperpigmented or hypopigmented lesions, depending on the outcome of interactions between Malassezia yeasts and the skin, such as lipoperoxidation process, stimulus of inflammatory cell to melanocytes, and increased thickness of keratin layer. Objective To investigate skin characteristic factors that enhance the susceptibility to Malassezia yeasts and provoke different color changes of pityriasis versicolor patien...

  10. Pityriasis Rosea Like Drug Rash – A Need to Identify the Disease in Childhood

    OpenAIRE

    Panda, Maitreyee; Patro, Nibedita; Jena, Monalisa; Dash, Mrutunjay; Mishra, Swati

    2014-01-01

    Pityriasis rosea is a common dermatosis named by Gibert in 1860. It is an acute self limiting papulosquamous disease, probably infective in origin affecting healthy adolescents and young adults. It is characterized by distinctive skin eruptions and minimal constitutional symptoms. Drug induced pityriasis rosea tend to occur in older generation and resolution seen only after withdrawal of the offending drug. We report a case of 12-year-old boy with erythematous papules distributed over trunk a...

  11. The evaluation of local oxidative/nitrosative stress in patients with pityriasis versicolor: a preliminary study.

    Science.gov (United States)

    Kurutas, Ergul Belge; Ozturk, Perihan

    2016-11-01

    Yeast of Malassezia, members of the microbiologic flora of the skin, cause pityriasis versicolor and have also been implicated in the pathogenesis of other superficial dermatoses. The mechanisms by which the yeast cause these dermatoses, however, are not yet clear, and there have been no studies on the interaction between fungi and keratinocytes, especially the effects of fungi on the production of reactive oxygen/nitrogen species by human keratinocytes. This is the first study we aimed to evaluate the role of oxidative/nitrosative stress in affected skin areas in patients with pityriasis versicolor. Sixty pityriasis versicolor patients and 60 healthy subjects as control group were enrolled. Scraping samples were obtained from the lesional skin areas in patients and from the normal skin areas in controls. The distribution of lesions of pityriasis versicolor was mild in all patients. We have isolated two Malassezia species: M. furfur being isolated in 75% of patients, followed by M. globosa (25%). The levels of oxidative/nitrosative stress biomarkers were significantly higher in patients than the controls (P pityriasis versicolor is associated with significant alteration in oxidant/antioxidant balance. It might be secondary consequence of pityriasis versicolor infection or contributing factor in its pathogenesis. © 2016 Blackwell Verlag GmbH.

  12. Tissue immunostaining for factor XIIIa in dermal dendrocytes of pityriasis alba skin lesions*

    Science.gov (United States)

    Carneiro, Francisca Regina Oliveira; do Amaral, Gabriela Borborema; Mendes, Maiana Darwich; Quaresma, Juarez Antônio Simões

    2014-01-01

    BACKGROUND Pityriasis alba affects 1% of the world population and about 9.9% of the children in Brazil. However, its etiology remains uncertain. OBJECTIVE The objective of the present study was to evaluate the immunoexpression of factor XIIIa in dermal dendrocytes of skin lesions of pityriasis alba. METHOD Twenty patients with pityriasis alba and 20 patients with atopic dermatitis underwent biopsy. The dermal dendrocytes marked by factor XIIIa were counted by means of immunohistochemical analysis. RESULTS The mean amount of dermal dendrocytes found in the patients with pityriasis alba was 2, whereas in the patients with atopic dermatitis it was 4, with a statistically significant difference between them. A cutoff point of 3 cells/square inch was established to differentiate pityriasis alba from atopic dermatitis, with 80% sensibility and 90% specificity. CONCLUSION We believe that pityriasis alba and atopic dermatitis should be considered different clinical forms within the spectrum of atopic disease, in which sun radiation plays an important role by modulating the progression of the disease. PMID:24770500

  13. Tissue immunostaining for factor XIIIa in dermal dendrocytes of pityriasis alba skin lesions.

    Science.gov (United States)

    Carneiro, Francisca Regina Oliveira; Amaral, Gabriela Borborema do; Mendes, Maiana Darwich; Quaresma, Juarez Antônio Simões

    2014-01-01

    Pityriasis alba affects 1% of the world population and about 9.9% of the children in Brazil. However, its etiology remains uncertain. The objective of the present study was to evaluate the immunoexpression of factor XIIIa in dermal dendrocytes of skin lesions of pityriasis alba. Twenty patients with pityriasis alba and 20 patients with atopic dermatitis underwent biopsy. The dermal dendrocytes marked by factor XIIIa were counted by means of immunohistochemical analysis. The mean amount of dermal dendrocytes found in the patients with pityriasis alba was 2, whereas in the patients with atopic dermatitis it was 4, with a statistically significant difference between them. A cutoff point of 3 cells/square inch was established to differentiate pityriasis alba from atopic dermatitis, with 80% sensibility and 90% specificity. We believe that pityriasis alba and atopic dermatitis should be considered different clinical forms within the spectrum of atopic disease, in which sun radiation plays an important role by modulating the progression of the disease.

  14. Pityriasis rosea-like drug reaction to asenapine.

    Science.gov (United States)

    Makdisi, Joy; Amin, Bijal; Friedman, Adam

    2013-09-01

    Pityriasis rosea (PR) is a relatively common, benign skin disease of unknown etiology. In rare cases, medications can induce a morphologically similar eruption. We present a case of a PR-like drug eruption caused by the atypical antipsychotic asenapine. The clinical presentation consisted of a rapidly progressive, disseminated, and severely pruritic dermatitis comprised of ovoid, scaly, pink-violaceous plaques. The initial histopathologic specimen was consistent with PR, but upon re-sampling a week later, the findings favored a drug eruption. PR-like drug eruptions, though rare, can occur in response to a wide variety of medications. Because the findings may be only subtly different than those of typical PR, careful clinical and histopathological correlation must be sought. To our knowledge, this is the first reported case of a PR-like drug eruption to asenapine.

  15. Immunological study of Pityriasis versicolor and Pityrosporum folliculitis

    Directory of Open Access Journals (Sweden)

    Mittal R

    1992-01-01

    Full Text Available Twenty five cases of pityriasis versicolor and 25 cases of pityrosporum folliculitis were selected for this study. Skin scrapings in 10% potassium hydroxide showed spores and hyphae in all 25 cases of PV. Smears from PF showed Gram positive spores in all 25 cases and in addition few short hyphae in 3 cases. Initially IgM and Later both IgM and IgG were raised. Similar response was seen in PF initially and later IgM, IgG and IgA all were raised in PF. Though antibody levels were slightly higher in PF, yet basically the pattern was similar in PV and PF.

  16. Study of oral Ketoconazole on recurrent & extensive Pityriasis Versicolor

    Directory of Open Access Journals (Sweden)

    Moghaddami M

    1997-04-01

    Full Text Available Several topical agents have been used for treating Pityriasis versicolor. But the main problem is recurrence. In this study 82 patients with recurrent and/or extensive from of infection were treated with oral Ketoconazole. 200 mg once daily for a maximum of 4 weeks. Seventeen patients have been infected for the first time and sixty five for the several times. The duration of disease in most cases (35.4% were between 1-3 years. Out of 82 studied patients only 60 cases were referred for follow up. The clinical and mycological cure were seen in 54 cases (90% after 15 days therapy. In other 6 patients after 15 days the lesions have not cured completely so the treatment was continued for other 2 weeks, but after that, only one of them referred to the clinic, which treatment extended with topical therapy.

  17. The morphology of keratohyalin granules in orthokeratotic and parakeratotic skin and oral mucosa.

    Science.gov (United States)

    Westerhof, W; Dingemans, K P

    1987-06-01

    We compared morphologic features of keratohyalin granules (KHG) that were directly related to keratinization in oral mucosa (tongue, cheek, gums, palate; n = 4) with those in parakeratotic epidermis (psoriasis, n = 2; pityriasis rubra pilaris, n = 1; acute dermatitis, n = 1) and normal orthokeratotic epidermis. Among others, the ultrastructural features of globular KHG were observed in the cheek, nonspecialized tongue mucosa, and parakeratotic epidermis occurring in psoriasis, pityriasis rubra pilaris, and acute dermatitis, whereas gums and palate showed a mixture of characteristics, also resembling stellate KHG as seen in normal skin. From literature as well as from our studies, the impression was gained that globular KHG were found especially in quickly dividing epithelia and could easily be distinguished from the irregular or stellate KHG that were found in slowly dividing normal epidermis. Therefore, we studied keratinization features on days 3, 7, and 14 after autografting normal human skin (n = 4), thus inducing high cell turnover. Stellate KHG, present in granular cells of normal skin, were almost absent on the third day. Active cell division on the seventh day resulted in sparse keratohyalin formation inside globular granules of low electron density, whereas numerous, rather electron-translucent lipid droplets occurred in upper spinous and horny cells. These two phenomena seemed to be interrelated. After 14 days, round and increasingly electron-dense KHG were noted.(ABSTRACT TRUNCATED AT 250 WORDS)

  18. Skin Characteristics in Patients with Pityriasis Versicolor Using Non-Invasive Method, MPA5.

    Science.gov (United States)

    Park, Hyun Jung; Lee, Yang Won; Choe, Yong Beom; Ahn, Kyu Joong

    2012-11-01

    Skin pigmentary changes of pityriasis versicolor may occur as either hyperpigmented or hypopigmented lesions, depending on the outcome of interactions between Malassezia yeasts and the skin, such as lipoperoxidation process, stimulus of inflammatory cell to melanocytes, and increased thickness of keratin layer. To investigate skin characteristic factors that enhance the susceptibility to Malassezia yeasts and provoke different color changes of pityriasis versicolor patients. To clarify these factors, we investigated the skin characteristics of pityriasis versicolor patients, using a non-invasive method known as MPA 5® (Courage and Khazaka, Germany). A total of 90 normal healthy subjects and 30 pityriasis versicolor patients were included in this study. Both hyperpigmented and hypopigmented pityriasis versicolor skin lesions showed higher humidity, increased sebum excretion rate and increased transepidermal water loss (TEWL) values than normal healthy subjects. But no significant difference of specific Malassezia yeasts species between hyperpigmented and hypopigmented skin lesions was evident. These results indicate that higher humidity and increased sebum level provide a better growing environment of Malassezia yeasts in the skin, leading to the assumption that interaction between Malassezia yeasts and skin barrier materials makes disruption of skin barrier causing increased TEWL.

  19. Comparative study of effectiveness of oral acyclovir with oral erythromycin in the treatment of Pityriasis rosea.

    Science.gov (United States)

    Amatya, A; Rajouria, E A; Karn, D K

    2012-01-01

    Pityriasis rosea is an acute, self-limiting disease, probably infective in origin, affecting mainly children and young adults, characterized by distinctive skin eruptions and minimal constitutional symptoms. Both oral Erythromycin and oral Acyclovir have been used in its management. To compare the effectiveness of oral Erythromycin and oral Acyclovir in the treatment of Pityriasis rosea. Forty two patients with clinical diagnosis of Pityriasis rosea were enrolled. They were randomized into two groups. One group was given high-dose oral Acyclovir and another group oral Erythromycin in standard dose. The participants were evaluated one, two, four, six and eight weeks and six months after commencement of the study. Forty two patients including 26 males and 16 females completed the study. After 8th week, all patients showed complete response in both the groups. The response to oral Acyclovir compared with that to oral Erythromycin was better and was statistically significant in 1st, 2nd, 4th and 6th weeks. Although it is a self-limiting disease which resolves within three weeks to three months, this study reveals that both oral Acyclovir and oral Erythromycin are helpful in decreasing the severity and duration of Pityriasis rosea. Moreover, the study also indicates that oral Acyclovir is more effective than oral Erythromycin in reducing the severity and duration of Pityriasis rosea.

  20. Pityriasis versicolor: A clinicomycological and epidemiological study from a tertiary care hospital

    Directory of Open Access Journals (Sweden)

    Ghosh Sudip

    2008-01-01

    Full Text Available Background: Pityriasis versicolor is a mild, chronic, usually asymptomatic superficial fungal infection of the stratum corneum, caused by Malassezia yeasts. The purpose of the present study is to assess the clinical profile of a group of patients with pityriasis versicolor and to find out the epidemiological characteristics in this part of India as well as any association, if any, with other diseases. Materials and Methods: For this purpose, 110 consecutive patients of pityriasis versicolor were evaluated clinically and diagnosis was confirmed mycologically at a tertiary care hospital in Kolkata. All data were recorded in a predesigned, pretested semi-structured schedule. The total duration of study period was 12 months. Results: Majority of the patients were young adults. Most of the patients were asymptomatic. There is prominent seasonal variation of the patients with a peak in August and September months. Most of the lesions were hypopigmented scaly macules and were KOH positive. Most commonly involved sites were chest, face and back. Seborrheic dermatitis sometimes coexisted with pityriasis versicolor and a number of patients also had diabetes mellitus and immunosuppressive conditions. Conclusions: Overall, the clinicomycological and epidemiological profile of pityriasis versicolor infection as observed in a tertiary care setting in eastern India does not differ significantly from those observed by previous workers elsewhere.

  1. Isolation of Malassezia globosa and M. sympodialis from patients with pityriasis versicolor in Spain.

    Science.gov (United States)

    Aspiroz, Carmen; Ara, Mariano; Varea, Marzo; Rezusta, Antonio; Rubio, Carmen

    2002-01-01

    Pityriasis versicolor is a superficial infection of the stratum corneum by several yeast species formerly collectively named Malasseziafurfur. The genus Malassezia has been recently enlarged with new species. With the exception of M. pachydermatis, the remaining six species have an absolute requirement in vitro for supplementation of long-chain fatty acids in media. These lipophilic yeasts comprise six species: M. furfur, M. globosa, M. obtusa, M. restricta, M. slooffiae and M. sympodialis. The aim of this study was to establish whether there was any association between the various species of Malassezia and pityriasis versicolor lesions. Thus, we studied the isolates from 79 patients with pityriasis versicolor, both from lesions and from apparently healthy skin close to the visible lesions. In pityriasis versicolor lesions, the species most frequently isolated was M. globosa (90%), followed by M. sympodialis (41%). Almost all isolates (99%) belonged to one of these two species. The most frequent pattern was M. globosa as the sole species (58% of cases), although the association with M. sympodialis was also frequent (30%). These results confirmed M. globosa as the main agent of pityriasis versicolor and M. sympodialis as the second agent in importance. Malassezia globosa was found to be a species with high levels of esterase and lipase enzymes of probable importance in their pathogenicity.

  2. Atrophic pityriasis versicolor occurring in a patient with Sjögren's syndrome.

    Science.gov (United States)

    Marinello, Elena; Piaserico, Stefano; Alaibac, Mauro

    2017-01-18

    Pityriasis versicolor is one of the most frequent epidermal mycotic infections in the world, but its atrophic variant is rarely described. The aetiology of the atrophy is still unknown, and two main hypotheses have been formulated, one suggesting a correlation with long-term use of topical steroids and the other a delayed type hypersensitivity to epicutaneous antigens derived from components of the fungus. Atrophic pityriasis versicolor is a benign disease, but needs to be distinguished from other more severe skin diseases manifesting with cutaneous atrophy. The diagnosis can be easily confirmed by direct microscopic observation of the scales soaked in 15% potassium hydroxide, which reveals the typical 'spaghetti and meatball' appearance, or by a skin biopsy in doubtful cases. Here, we describe a case of extensive atrophic pityriasis versicolor occurring in a woman affected by Sjögren's syndrome which completely resolved after topical antifungal treatment. 2017 BMJ Publishing Group Ltd.

  3. Molecular identification and prevalence of malassezia species in pityriasis versicolor patients from kashan, iran.

    Science.gov (United States)

    Talaee, Rezvan; Katiraee, Farzad; Ghaderi, Maryam; Erami, Mahzad; Kazemi Alavi, Azam; Nazeri, Mehdi

    2014-08-01

    Malassezia species are lipophilic yeasts found on the skin surface of humans and other warm-blooded vertebrates. It is associated with various human diseases, especially pityriasis versicolor, which is a chronic superficial skin disorder. The aim of the present study was to identify Malassezia species isolated from patients' samples affected by pityriasis versicolor, using molecular methods in Kashan, Iran. A total of 140 subjects, suspected of having pityriasis versicolor from Kashan, were clinically diagnosed and then confirmed by direct microscopic examination. The scraped skin specimens were inoculated in modified Dixon's medium. DNA was extracted from the colonies and PCR amplification was carried out for the 26s rDNA region. PCR products were used to further restriction fragment length polymorphism by CfoI enzyme. Direct examination was positive in 93.3% of suspected pityriasis versicolor lesions. No statistically significant difference was observed in the frequency of Malassezia species between women and men. The highest prevalence of tinea versicolor was seen in patients 21-30 years-of-age. No difference could be seen in the frequency of Malassezia species depending on the age of the patients. In total, 65% of patients with pityriasis versicolor had hyperhidrosis. The most commonly isolated Malassezia species in the pityriasis versicolor lesions were; Malassezia globosa (66%), M. furfur (26%), M. restricta (3%), M. sympodialis (3%), and M. slooffiae (2%). Malassezia species were mainly isolated from the neck and chest. This study showed M. globosa to be the most common Malassezia species isolated from Malassezia skin disorders in Kashan, Iran. The PCR-RFLP method was useful in the rapid identification of the Malassezia species. By using these methods, the detection and identification of individual Malassezia species from clinical samples was substantially easier.

  4. Granulosis rubra nasi – a case report. A literature review

    Directory of Open Access Journals (Sweden)

    Brzezinski Piotr

    2011-07-01

    Full Text Available Granulosis Rubra Nasi (GRN, a rare childhood dermatitis that was also defined as "Acne papulo-rosacea of the nose". Is an inflammatory dermatosis which consists on erythema, papules and itch. The hyperhidrosis the most conspicuous features of the disease and small beads of sweat and erythema on the tip of the nose may often occur. Sometimes small red papules and comedo-like lesions may be present. Etiology is unknown. lt's uncommon, chronic process and benign course. Usually subsides spontaneously at adolescence. The treatment is symptomatic and cosmetic. An 14-year-old boy presented with erythematous lesions over the nose of childhood duration without sensitivity to sunlight. Physical examination showed also excessive sweating of the nose, and erythema of the nose covered by small pustules, papules ang macules. The patient responded well to low doses of oral Isotretinoine. Should remember GRN could be a complication of hyperhidrosis.

  5. meta-Tyrosine in Festuca rubra ssp. commutata (Chewings fescue) is synthesized by hydroxylation of phenylalanine.

    Science.gov (United States)

    Huang, Tengfang; Rehak, Ludmila; Jander, Georg

    2012-03-01

    m-Tyrosine is a non-protein amino acid that is structurally similar to the common protein amino acids p-tyrosine and phenylalanine. Copious amounts of m-tyrosine can be found in root exudates of the fine fescue cultivar, Festuca rubra L. ssp. commutata (Chewings fescue). The phytotoxicity of m-tyrosine may contribute to the allelopathic potential of F. rubra. m-Tyrosine in Euphorbia myrsinites (donkey-tail spurge), was previously shown to be synthesized via transamination of m-hydroxyphenylpyruvate. Here we show that m-tyrosine biosynthesis in F. rubra occurs through direct hydroxylation of phenylalanine in the root tips, perhaps through the activity of a cytochrome P450 enzyme. Hence, E. myrsinites and F. rubra, the only two plant species known to produce m-tyrosine, use distinct biosynthetic pathways that likely arose independently in evolutionary history.

  6. Comparative study of efficacy of 30% Salicylic acid peel VsLong-pulsed 1064 nm Nd:YAG laser for treatment of Keratosis Pilaris

    Directory of Open Access Journals (Sweden)

    Zonunsanga

    2015-04-01

    Full Text Available Introduction: Keratosis pilaris(KP is a disorder of keratinization of hair follicles characterized by keratin plugs in the hair follicles with perifollicular erythema. It may be inherited with X-Linked Dominant, or may be sporadic. Aim of the study: to compare the efficacy of 30% Salicylic acid and Long pulsed 1064nm Nd:YAG laser for treatment of keratosis pilaris. Materials and Methods: Out of 20 patients, 10 patients were given 30% Salicylic acid peel (after washing their face every 15 days for 2 months. Another 15 patients were given the 1064 nm Nd:YAG Long pulse, Spot size: 10 mm, Pulse width: 30 ms every 4-6 weeks for 4 sitting. Results: Among salicylic acid treated group, only 2 out of 10 showed improvement between 50-75%, and were slightly satisfied; none showed >75% improvement, and 8 out of 10 failed to show >50% improvement and were considered as failure of the therapy. Among the Nd:YAG treated group, 3 out of 10 showed 50-75% improvement and were slightly satisfied;none showed > 75% improvement, 7 out 10 failed to show successful results i.e. >50% improvement. Conclusion: Both of the treatments are not much effective and do not give consistent and satisfactory results for treatment of keratosis pilaris.

  7. The Oxidant and Antioxidant Status in Pityriasis Rosea

    Science.gov (United States)

    Emre, Selma; Akoglu, Gulsen; Metin, Ahmet; Demirseren, Duriye Deniz; Isikoglu, Semra; Oztekin, Aynure; Erel, Ozcan

    2016-01-01

    Background: Pityriasis rosea (PR) is usually an asymptomatic and self-limiting papulosquamous skin disease with acute onset. The etiology has not been clarified yet. Recently, increased oxidative stress was found to play a role in etiopathogenesis of multiple cutaneous diseases with T cell-mediated immune response. However, there are no studies demonstrating the oxidative stress status in PR. Aim: The aim of the study is to determine the status of oxidative stress (OS) and paraoxonase (PON) 1/arylesterase enzyme activities in PR. Materials and Methods: Study included 51 patients with active PR lesions, and 45 healthy volunteers. Serum levels of total oxidant status (TOS), total antioxidant status (TAS), and PON1/arylesterase (ARES) activity were determined and oxidative stress index (OSI) was calculated in all patients and controls. Results: TAS levels and ARES activities in the patient group were significantly lower than the control group. On the other hand, TOS and OSI levels were significantly higher in patients compared with controls. There was no significant correlation between the duration of disease and TAS, TOS, OSI levels, and ARES activities. Conclusion: A systemic oxidative stress exists in PR, which suggests that OS may be involved in the etiopathogenesis of disease. PMID:26955119

  8. The oxidant and antioxidant status in pityriasis rosea

    Directory of Open Access Journals (Sweden)

    Selma Emre

    2016-01-01

    Full Text Available Background: Pityriasis rosea (PR is usually an asymptomatic and self-limiting papulosquamous skin disease with acute onset. The etiology has not been clarified yet. Recently, increased oxidative stress was found to play a role in etiopathogenesis of multiple cutaneous diseases with T cell-mediated immune response. However, there are no studies demonstrating the oxidative stress status in PR. Aim: The aim of the study is to determine the status of oxidative stress (OS and paraoxonase (PON 1/arylesterase enzyme activities in PR. Materials and Methods: Study included 51 patients with active PR lesions, and 45 healthy volunteers. Serum levels of total oxidant status (TOS, total antioxidant status (TAS, and PON1/arylesterase (ARES activity were determined and oxidative stress index (OSI was calculated in all patients and controls. Results: TAS levels and ARES activities in the patient group were significantly lower than the control group. On the other hand, TOS and OSI levels were significantly higher in patients compared with controls. There was no significant correlation between the duration of disease and TAS, TOS, OSI levels, and ARES activities. Conclusion: A systemic oxidative stress exists in PR, which suggests that OS may be involved in the etiopathogenesis of disease.

  9. Pitiríase rósea Pityriasis rosea

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    Sandra Maria Bitencourt Miranda

    2008-10-01

    Full Text Available Pitiríase rósea é doença inflamatória aguda da pele, que regride espontaneamente, normalmente sem deixar seqüelas, em período que varia de quatro a oito semanas. Clinicamente é caracterizada pelo aparecimento de típicas lesões eritêmato-pápulo-escamosas. Atinge todas as idades, embora seja mais comumente observada entre 10 e 35 anos. Apesar de exaustivas pesquisas, sua etiologia ainda permanece desconhecida. São discutidos alguns aspectos epidemiológicos, anatomoclínicos, diagnósticos diferenciais, doenças associadas, com ênfase no tratamento e etiologia da doença.Pityriasis rosea is a skin disease characterized by acute inflammation that fades away spontaneously without scar tissue formation for an average period of 4 to 8 weeks. Clinically, it is characterized by the occurrence of typical erythematous papulosquamous lesions distributed mainly over the trunk and extremities. It affects people of all ages, but is more often observed in the age range of 10 to 35 years. Even though it is extensively studied, its etiology remains unknown. In this study, the authors analyze some epidemiologic aspects, differential diagnosis, related diseases, and give special attention to treatment and possible etiology.

  10. [Pityriasis versicolor : new aspects of an old disease].

    Science.gov (United States)

    Mayser, P A; Preuss, J

    2012-11-01

    Pityriasis versicolor (PV) is one of the most common infectious skin diseases, as well as the most common dermatosis associated with pigmentation alterations of the skin. PV is prevalent in 1% of the population living in temperate climate zones and more common during the summer. In tropical areas, PV is found in up to 50% of all patients consulting a dermatologist. Of the known Malassezia species, M. globosa is currently felt to play a key role in the pathogenesis of PV, as it is most commonly found in PV lesions. In addition, its round-shaped cells may contribute to the characteristic histology of the disease ("spaghetti and meatballs"). However, the clinical appearance of PV including hyper- and hypopigmentation, fluorescence of the lesions, as well as a lack of inflammation despite high fungal load cannot fully be explained by the presence of M. globosa, which is also found on healthy skin. In M. furfur a tryptophan-dependent metabolic pathway generates a number of indole pigments, which may be associated with the clinical appearance of PV. In the model organism Ustilago maydis it was shown that the formation of the indole compounds occurs spontaneously after initial conversion of tryptophan into indole pyruvate controlled by the key enzyme aminotransferase Tam 1. We review the present knowledge of PV and highlight the potential role of Tam1 in explaining the poorly understood aspects of the disease. Promising therapeutic results using the application of Tam1 inhibitors to treat PV support the enzyme's important role in the disease pathogenesis.

  11. EFFECT OF VARIOUS GROWING MEDIA AND FERTILIZER LEVELS ON GROWTH OF Antherura Rubra Lour

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    Fitri Kurniawati

    2016-06-01

    Full Text Available Antherura rubra Lour is one of the critical plant at Cibodas Botanical Garden. Study of cultivation through vegetative propagation of A. Rubra is rare. Therefore, the research of A. rubra on various of media and inorganic fertilizers is required to conserve A.rubra at Cibodas Botanical Garden. This study was conducted at the Nursery - Cibodas Botanic Garden for 10 months. The experiment was conducted in randomized block design (RBD with four replications. Treatments consisted of three combinations of natural compost media with three levels of inorganic fertilizer (0, 1g/L, and 2g/L, three katalek compost combination with three levels of inorganic fertilizer and a control (top soil without inorganic fertilizers. Variable tested consists of plant height, number of leaves, and dry weight shoot and root as an indicator of growth A. rubra Lour The results showed that the growth of seedlings A. rubra Lour on katalek compost media's with one dose of levels inorganic fertilizer growth better than other treatments.

  12. A child with PFAPA syndrome complicated by pityriasis lichenoides et varioliformis acuta.

    Science.gov (United States)

    Iba, Yoshinori; Sugimoto, Keisuke; Sakata, Naoki; Kawada, Akira; Takemura, Tsukasa

    2011-01-01

    We encountered a boy with periodic fever, aphthous-stomatitis, pharyngitis, adenitis syndrome, complicated by a papular rash representing pityriasis lichenoides et varioliformis acuta. Proinflammatory cytokines have been implicated in both diseases and may represent the underlying common immunologic mechanism causing the two diseases. © 2011 Wiley Periodicals, Inc.

  13. Hypopigmented pityriasis versicolor on Becker′s naevus : Hope for new method of treatment ?

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    Singal Archana

    1998-01-01

    Full Text Available A case of hypopigmented pityriasis versicolor superimposed on pre existing Becker′s naevus associated with congenital melanocytic naevus is being reported for its rarity. The possible role of dicarboxylic acid and other free radicles produced by Pityrosporum ovale in treating Becker′s Naevus is also suggested.

  14. Pityriasis Rotunda: A Case Report of Familial Disease in an American-Born Black Patient

    Science.gov (United States)

    Lefkowitz, Emily G.; Natow, Allen J.

    2016-01-01

    Pityriasis rotunda is an uncommon dermatosis with an unusual geographic and racial distribution. The skin disorder is characterized by sharply defined, perfectly circular, scaly patches with no inflammatory changes. Notably, it may be associated with underlying malignancy or chronic infection. We report an uncommon familial case in an American-born female. PMID:27065844

  15. A Herald Patch Almost Encircling the Trunk-Extreme Pityriasis Rosea Gigantea in a Young Child.

    Science.gov (United States)

    Chuh, Antonio

    2016-09-01

    An 18-month-old girl presented with pityriasis rosea gigantea. The herald patch encircled almost the entire trunk. The distribution of lesions on the trunk and proximal aspects of the limbs, the collarette scaling, the orientation of some lesions along the skin crease lines, and biopsy findings substantiated the diagnosis. © 2016 Wiley Periodicals, Inc.

  16. SIXTEEN YEARS OF PITYRIASIS VERSICOLOR IN METROPOLITAN AREA OF PORTO ALEGRE, SOUTHERN BRAZIL.

    Science.gov (United States)

    Heidrich, Daiane; Daboit, Tatiane Caroline; Stopiglia, Cheila Denise Ottonelli; Magagnin, Cibele Massotti; Vetoratto, Gerson; Amaro, Taís Guarienti; Scroferneker, Maria Lúcia

    2015-01-01

    Pityriasis versicolor is the most common of the diseases caused by Malassezia yeasts. The aim of this study is to determine the prevalence of pityriasis versicolor and its etiological aspects in the metropolitan area of Porto Alegre, Brazil. A retrospective cross-sectional study with data from patients of a reference hospital from 1996 to 2011 was performed. Collected data included: date, age, gender, ethnicity, anatomical region of lesion and the direct mycological examination results. Among the positive results in the direct mycological examination, 5.8% (2,239) were positive for pityriasis versicolor. The angular coefficient (B) was -0.3%/year, showing a decrease over the years. The disease was more prevalent in men (7.1% of men versus 5.1% of women that underwent the direct mycological examination); younger age (median 31 years old); "pardo" and black people (3.7% more than expected in the sample); trunk (73.44% of the affected anatomic sites). Lesions in rare sites (groin, genitals, legs, feet and hands) were also observed in this study. In conclusion, due to the decrease in the prevalence of pityriasis versicolor, long-term epidemiological studies in the metropolitan area of Porto Alegre, Brazil, are needed to continue the monitoring of this disease.

  17. Pityriasis versicolor: clinical experience with Lamisil cream and Lamisil DermGel.

    Science.gov (United States)

    Faergemann, J; Hersle, K; Nordin, P

    1997-01-01

    Pityriasis versicolor is a chronic superficial fungal disease usually located on the upper trunk, neck or upper arms. Terbinafine is an orally and topically active allylamine antifungal derivative with a broad antifungal spectrum. Several studies have documented the high activity of terbinafine (Lamisil) cream in the treatment of pityriasis versicolor, with cure rates of 79-100% after 2-4 weeks of treatment. Lamisil emulsion gel (Lamisil DermGel) is a new topical formulation that remains in the skin in high concentrations for several months after just 1 week of application. Recently, in a prospective, double-blind, placebo-controlled, randomised, parallel-group, comparative, multicentre study, we have treated patients with pityriasis versicolor with either terbinafine 1% emulsion gel (Lamisil DermGel) or placebo gel. Sixty-one patients were included, 31 in the Lamisil DermGel group and 30 in the placebo gel group. The gel was applied once daily for 7 days and the patients were followed up for 8 weeks. Twenty-eight patients in the active and 29 patients in the placebo group were evaluable for efficacy. Using the intent-to-treat efficacy analysis, 21/28 (75%) were cured in the Lamisil-DermGel-treated group compared to 4/29 (14%) in the placebo group. No side-effects were seen. In conclusion, Lamisil DermGel was well tolerated and superior to placebo in the treatment of pityriasis versicolor when applied once daily for 7 days.

  18. Pityriasis Rotunda: A Case Report of Familial Disease in an American-Born Black Patient

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    Emily G. Lefkowitz

    2016-03-01

    Full Text Available Pityriasis rotunda is an uncommon dermatosis with an unusual geographic and racial distribution. The skin disorder is characterized by sharply defined, perfectly circular, scaly patches with no inflammatory changes. Notably, it may be associated with underlying malignancy or chronic infection. We report an uncommon familial case in an American-born female.

  19. Prevalence of Malassezia species in patients with pityriasis versicolor in Rosario, Argentina

    OpenAIRE

    2011-01-01

    Background Malassezia species are considered opportunistic yeasts of increasing clinical importance. These lipophilic yeasts are associated with various human diseases, especially pityriasis versicolor (PV), a chronic superficial scaling dermatomycosis. Aims The aim of this study was to isolate, identify and analyze the distribution of the different species of Malassezia in patients with PV in Rosario city (Argentina). Methods A total of 264...

  20. Identification and speciation of Malassezia in patients clinically suspected of having pityriasis versicolor

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    Avani Shah

    2013-01-01

    Full Text Available Background: Malassezia is a lipid-dependent yeast known to cause Pityriasis versicolor, a chronic, recurrent superficial infection of skin and present as hypopigmented or hyperpigmented lesions on areas of skin. If not diagnosed and treated, it may lead to disfigurement of the areas involved and also result in deep invasive infections. Aim: The aim of the present study was to identify and speciate Malassezia in patients clinically suspected of having Pityriasis versicolor. Materials and Methods: Total 139 patients suspected of having Pityriasis versicolor were evaluated clinically and diagnosis was done by Wood′s lamp examination, confirmed mycologically by using KOH, cultivation on Sabouraud′s dextrose agar and modified Dixon agar at a tertiary care hospital in Mumbai. The total duration of study was 12 months. Results: Majority of the patients were males (59.71% in the age group of 21-30 years (33.81% who were students (30.21% by profession. The incidence of Malassezia in Pityriasis versicolor was 50.35%. The most common isolate was M. globosa (48.57%, followed by M. furfur (34.28%. Majority of the patients had hypopigmented lesions, with M. globosa as the predominant isolate. Neck was the most common site affected; 88.48% were Wood′s lamp positive of which 56.91% of Malassezia isolates grew on culture. KOH mount was positive in 82.01% of which 61.40% Malassezia isolates grew on culture. Conclusions: The procedure of culture and antifungal testing is required to be performed as different species of Malassezia are involved in Pityriasis versicolor and susceptibility is different among different species. Thus, it would help to prevent recurrences and any systemic complications.

  1. DISTRIBUTION OF MALASSEZIA SPECIES IN PATIENTS WITH PITYRIASIS VERSICOLOR AND HEALTHY INDIVIDUALS IN SOUTH INDIA

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    Kavitha

    2016-04-01

    Full Text Available BACKGROUND Pityriasis Versicolor is a superficial infection of the stratum corneum which is caused by a group of yeasts called Malassezia. OBJECTIVES To isolate and identify the causative fungi from clinically suspected cases of Pityriasis Versicolor by 10% KOH and to compare the results of 10% KOH with culture. METHODS 100 clinically diagnosed cases of Pityriasis Versicolor of all age groups and both sexes, attending the Outpatient Department of Dermatology at Bapuji Hospital and Chitageri Hospital were included in this study. Skin scrapings from lesions of all cases were subjected to 10% KOH examination and culture. A control group of 50 healthy individuals was studied to know the normal fungal flora of the skin. Differentiation of all Malassezia species performed using morphological features and physiological tests including catalase reaction, Tween assimilation test and splitting of esculin. RESULTS Out of 100 clinically diagnosed Pityriasis Versicolor cases, 97(97% cases showed characteristic arrangement of fungal elements in 10% KOH preparation and culture was positive in 68 cases. The most frequently isolated species was M. globosa (54.41%, followed by M. furfur (25%, M. sympodialis (11.76% and M. obtusa (8.82%. In control group, M. globosa was the common isolate. CONCLUSION In comparison with culture results, the sensitivity and specificity of 10% KOH is 100% and 9.37% respectively. It does not require highly skilled personnel to perform or interpret results. The only disadvantage of KOH examination is that the Malassezia species cannot be differentiated. Culture is the gold standard, but it is time consuming and requires considerable expertise. Therefore, 10% KOH examination is a rapid, simple, sensitive and effective diagnostic test for Pityriasis Versicolor. M. globosa was the most common isolated species followed by M. furfur, M. sympodialis and M. obtusa

  2. Distribution of Malassezia species in patients with pityriasis versicolor in Turkey.

    Science.gov (United States)

    Rodoplu, G; Saracli, M A; Gümral, R; Taner Yildiran, S

    2014-06-01

    Pityriasis versicolor is a common superficial mycotic disease of the skin which is caused by different species of Malassezia genus. The aim of this study was to contribute to the knowledge of the aetiology of pityriasis versicolor (PV) with a mycological study made according to the new species and additionally, the success of the different sampling techniques, duration and recurrence history of the disease, distribution of infecting strains according to the affected body sites were also investigated. In total, 146 patients with pityriasis versicolor were included in this study. Fungal elements could only be visualized by potassium hydroxide examination in 36.4% of the samples. Specimens obtained by scraping skin surface by a sterile scalpel and/or sterile sticky plaster (OpSite) were inoculated in plates containing modified Dixon's medium. Out of 146 samples, 109 (74.7%) yielded a growth which was considered to be Malassezia spp. in culture. Species level identification of suspicious Malassezia yeasts was made according to their macroscopic and microscopic features, and their physiological characteristics. Among the identified species, Malassezia globosa (65.1%) was the most commonly isolated species, followed by Malassezia obtusa (17.4%). However, four Malassezia isolates could not be identified at species level with conventional methods. While most of the patients suffered their first episode of pityriasis versicolor (76%), back of the trunk was the mostly affected body site (39%). In conclusion, Malassezia globosa was found to be the predominant species in pityriasis versicolor patients in our region, and culture of the specimen is necessary for the epidemiologic purposes. Copyright © 2014. Published by Elsevier Masson SAS.

  3. Identification and speciation of malassezia in patients clinically suspected of having pityriasis versicolor.

    Science.gov (United States)

    Shah, Avani; Koticha, Avani; Ubale, Milind; Wanjare, Shashir; Mehta, Preeti; Khopkar, Uday

    2013-05-01

    Malassezia is a lipid-dependent yeast known to cause Pityriasis versicolor, a chronic, recurrent superficial infection of skin and present as hypopigmented or hyperpigmented lesions on areas of skin. If not diagnosed and treated, it may lead to disfigurement of the areas involved and also result in deep invasive infections. The aim of the present study was to identify and speciate Malassezia in patients clinically suspected of having Pityriasis versicolor. Total 139 patients suspected of having Pityriasis versicolor were evaluated clinically and diagnosis was done by Wood's lamp examination, confirmed mycologically by using KOH, cultivation on Sabouraud's dextrose agar and modified Dixon agar at a tertiary care hospital in Mumbai. The total duration of study was 12 months. Majority of the patients were males (59.71%) in the age group of 21-30 years (33.81%) who were students (30.21%) by profession. The incidence of Malassezia in Pityriasis versicolor was 50.35%. The most common isolate was M. globosa (48.57%), followed by M. furfur (34.28%). Majority of the patients had hypopigmented lesions, with M. globosa as the predominant isolate. Neck was the most common site affected; 88.48% were Wood's lamp positive of which 56.91% of Malassezia isolates grew on culture. KOH mount was positive in 82.01% of which 61.40% Malassezia isolates grew on culture. The procedure of culture and antifungal testing is required to be performed as different species of Malassezia are involved in Pityriasis versicolor and susceptibility is different among different species. Thus, it would help to prevent recurrences and any systemic complications.

  4. Demographical and Clinical Characteristics of Patients with Pityriasis Rosea in 1 Year in A Tertiary Care Hospital

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    Seval Karasatı

    2015-03-01

    Full Text Available Objective: Pityriasis rosea is a disease still taking interest with its unknown etiology, different clinical aspects and diagnosis and treatment alternatives. The clinical and demographical characteristics of the patients with pityriasis rosea were investigated in this study. Methods: A total of 70 patients, who were diagnosed as pityriasis rosea, between June 2011 and June 2012 were evaluated. The patients were examined prospectively in terms of their demographical characteristics, related environmental and personal factors, clinical characteristics and course of the disease. Results: The mean age of 70 patients (41 females, 29 males was 25.9±15.26 (2-69 years. Seasons in which the disease is seen most frequently were winter (37.1% and autumn (27.2%. The most common symptom was fatigue (64.3% in patients who had prodromal symptoms (n=28. Primary plaque was determined in 44 cases (58.6% and the most frequent localization was neck (22.7%. The most frequent symptom was pruritus and it was present in 41 patients. Eleven patients were diagnosed as atypical pityriasis rosea. One patient demonstrated unusual presentation of pityriasis rosea with localization to neck, and another one with secondary lesions on external ear tunnel which has not been described previously. Pityriasis rosea frequency in dermatology outpatients was 1/1000. Conclusion: The demographical results of this study were consistent with the results of the previously reported studies in Turkey.

  5. Pityriasis Rosea: A rash that should be recognized by the primary care physician. Study of 30 cases

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    Igor López-Carrera

    2014-08-01

    Full Text Available Background: Pityriasis rosea is an acute disseminated rash of unknown etiology and prolonged duration, characterized by erythematous- squamous plaques. Despite having an ostentatious clinical picture for both the patient and family, it is self-limited and usually resolves without sequelae. Pityriasis rosea is often erroneously diagnosed as mycosis and given unnecessary treatment. Objective: To describe the clinical and demographical features of pity- riasis rosea in a group of Mexican pediatric patients. Patients and methods: Retrospective and descriptive study in which the clinical and demographic features of patients attended at the department of dermatology of the National Institute of Pediatrics with diagnosis of pityriasis rosea within a ten year period were analysed. Results: Thirty patients with pityriasis rosea, with a frequency of 3.6 per 1000 dermatological patients. Pityriasis rosea was more frequent in females with a ratio of 1.5 to 1 and a mean age of 10 years. More than half of the patients (56% had an atypical presentation, and biopsy was mandatory in 7 patients to establish the final diagnosis. Conclusions: The knowledge of the clinical features of pityriasis rosea by primary care physicians will prevent from unnecessary work-up and treatments.

  6. Antithrombotic Effect and Mechanism of Radix Paeoniae Rubra

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    Pingyao Xie

    2017-01-01

    Full Text Available The compounds of Radix Paeoniae Rubra (RPR were isolated and identified by bioassay-guided method, and antithrombotic effects and mechanism were investigated by the acute blood stasis rat model. The RPR extract was evaluated by APTT, TT, PT, and FIB assays in vitro. Results indicated that RPR extract exhibited the anticoagulant activity. In order to find active compounds, six compounds were isolated and identified, and four compounds, paeoniflorin (Pae, pentagalloylglucose (Pen, albiflorin (Ali, and protocatechuic acid (Pro, exhibited the anticoagulant activity in vitro. Therefore, the antithrombosis effects of RPR extract and four active compounds were investigated in vivo by measuring whole blood viscosity (WBV, plasma viscosity (PV, APTT, PT, TT, and FIB. Meanwhile, the levels of TXB2, 6-Keto-PGF1α, eNOS, and ET-1 were detected. Results suggested that RPR extract and four active compounds had the inhibition effect on thrombus formation, and the antithrombotic effects were associated with the regulation of vascular endothelium active substance, activating blood flow and anticoagulation effect.

  7. Segmental lesions in pityriasis rosea: a rare presentation.

    Science.gov (United States)

    Zawar, Vijay; Godse, Kiran

    2011-01-01

    potassium hydroxide smear examination. The patient declined skin biopsy; however, we thought that the most diagnostic label for this condition was pityriasis rosea. Hence, we treated her with triamcinolone acetonide ointment 0.025% to be applied twice daily and desloratadine tablet 5 mg daily for 10 days. The patient demonstrated complete resolution, leaving postinflammatory hypopigmentation. There was no recurrence until 1 year after complete remission.

  8. Immune stimulatory activity of BRP-4, an acidic polysaccharide from an edible plant, Basella rubra L.

    Institute of Scientific and Technical Information of China (English)

    Hye-Jin Park

    2014-01-01

    Objective: To evaluated the immunomodulatory effect of BRP-4, an acidic polysaccharide from Basella rubra (B. rubra) L on the macrophage activity. Methods: Phagocytic activity was determined by the ingestion of Latex Beads-Rabbit IgG-FITC using the fluorescent microscopy and flow cytometry analysis and nitric oxide production was measured using Griess reaction assay. Results: An enhanced production of NO was observed at 10 and 100μg/mL of BRP-4. The phagocytic activity of macrophage was enhanced in BRP-4 treated RAW264.7 cells. BRP-4 combined with concanavalin A (Con A) provided obvious promotion and strengthening of the proliferation of the splenocytes. Conclusions: BRP-4, polysaccharide isolated from B. rubra, is suggested to activate macrophage function and stimulate splenocyte proliferation. The strong immunomodulatory activity of BRP-4 confirmed its good potential as an immunotherapeutic adjuvant.

  9. Removal of acorns of the alien oak Quercus rubra on the ground by scatter-hoarding animals in Belgian forests

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    Merceron, NR.

    2017-01-01

    Full Text Available Description of the subject. Quercus rubra L. is considered an invasive species in several European countries. However, little is known about its dispersal in the introduced range. Objectives. We investigated the significance of animal dispersal of Q. rubra acorns on the ground by vertebrates in its introduced range, and identified the animal species involved. Method. During two consecutive autumns, the removal of acorns from Q. rubra and from a native oak was assessed weekly in forest sites in Belgium. We used automated detection camera traps to identify the animals that removed acorns. Results. Quercus rubra acorns were removed by wood mice (Apodemus sylvaticus L., red squirrels (Sciurus vulgaris L., rats (Rattus sp., and wild boars (Sus scrofa L.. The two former are scatter-hoarding rodents and can be considered potential dispersers. Conclusions. Dispersal of Q. rubra acorns in Western Europe by scatter-hoarding animals may help the species increasingly colonize forest ecosystems.

  10. Clinico-epidemiological study of pityriasis versicolor in a rural tertiary care hospital

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    Nazeema Tabaseera

    2014-08-01

    Full Text Available Background: The study was conducted to know the incidence of pityriasis versicolor in relation to age, sex, seasons and occupation in a rural set up. Methods: A total of 105 patients of pityriasis versicolor were clinically evaluated and confirmed mycologically at central lab in a tertiary care hospital in South India. The obtained data was recorded and analysed accordingly. Results: Male preponderance was observed in the study. Disease was most pronounced in younger age group (21-30 years especially students. 61.9% of patients sought medical advice on cosmetic grounds while 38% had pruritis. Chest was the commonest site of affection followed by neck and back. Conclusion: Early identification of the yeast by simple laboratory techniques would help prevent recurrences, systemic complications and cosmetological problems which are high especially among the students and younger age groups. [Int J Res Med Sci 2014; 2(4.000: 1438-1440

  11. Comparative study of oral and topical ketoconazole therapy in pityriasis versicolor

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    Nagpal V

    2003-07-01

    Full Text Available Introduction: Both topical and systemic ketoconazole are reported to be effective against pityriasis versicolor. Material and Methods: Forty patients suffering from pityriasis versicolor were treated either with oral ketoconazole 200 mg per day or 2% ketoconazole cream topically once daily for 2 weeks. Results: On global assessment, after 2 weeks of start of therapy, 18 (90% out of 20 patients treated with oral ketoconazole were cured while 2 patients had considerable residual disease. In the ketoconazole cream group, 16 (80% out of 20 patients were cured and 4 patients had considerable residual disease. Conclusion: No significant difference was observed in the response rates in the two groups. Relapse occurred in two patients of the systemic ketoconazole group and six patients of the topical ketoconazole group during the follow-up period of three months.

  12. Prevalence of different Malassezia species in pityriasis versicolor in central India

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    Chaudhary Rahul

    2010-01-01

    Full Text Available Background: In the last 10 years, different studies have shown interesting geographical variations in the prevalence of different Malassezia species in pityriasis versicolor. Aim: Identification of Malassezia species isolated from patients with pityriasis versicolor. Methods: In 100 patients with pityriasis versicolor, Malassezia species were identified by culture in Sabouraud′s dextrose agar containing cycloheximide with olive oil overlay and modified Dixon agar and by doing biochemical tests (catalase reaction, assimilation of glycine, and Tween utilisation tests. Results: In 10 patients, 10% KOH smear was negative, while in 90 patients the smear showed characteristic "spaghetti and meatball" appearance. Of these 90 cases, growth was obtained on modified Dixon′s agar in 87 cases. Fifty of the isolates (57.5% were M. globosa, 15 (17.2% were M. sympodialis, seven (8.0% were suspected M. sympodialis, 6 (6.9% each of the isolates were M. furfur and M. obtusa, and three (3.4% isolates were M. restricta. Conclusion: M. globosa was the most common species, followed by M. sympodialis, M. furfur, M. obtusa, and M. restricta.

  13. Pityriasis Lichenoides in Childhood: Review of Clinical Presentation and Treatment Options.

    Science.gov (United States)

    Geller, Lauren; Antonov, Nina K; Lauren, Christine T; Morel, Kimberly D; Garzon, Maria C

    2015-01-01

    Pityriasis lichenoides (PL) is a skin condition of unclear etiology that occurs not uncommonly in childhood. It is often classified into the acute form, pityriasis lichenoides et varioliformis acuta (PLEVA), and the chronic form, pityriasis lichenoides chronica (PLC). We performed a comprehensive review of the English-language literature using the PubMed database of all cases of childhood PL reported from 1962 to 2014 and summarized the epidemiology, clinical features, treatment options, and prognosis of this condition in children. The proposed etiologies are discussed, including its association with infectious agents, medications, and immunizations and evidence for PL as a lymphoproliferative disorder. We found an average age of PL onset of 6.5 years, with a slight (61%) male predominance. We also found that PLEVA and PLC tend to occur with equal frequency and that, in many cases, there is clinical and histopathologic overlap between the two phenotypes. When systemic therapy is indicated, we propose that oral erythromycin and narrowband ultraviolet B phototherapy should be first-line treatment options for children with PL since they have been shown to be effective and well tolerated. In most cases, PL follows a benign course with no greater risk of cutaneous T-cell lymphoma, although given the rare case reports of transformation, long-term follow-up of these patients is recommended. © 2015 Wiley Periodicals, Inc.

  14. Pityriasis lichenoides chronica: case reports – the role of infectious agents?

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    Anca Chiriac

    2014-06-01

    Full Text Available Introduction. pityriasis lichenoides chronica (PLC, which is a benign eruption with lymphocytic infiltrates of the skin, presents as a persistent, erythematous, papular eruption with scale. Patients may have guttate, hypopigmented macules with scale in addition to papules. It is related histopathologically to pityriasis lichenoides et varioliformis acuta (PLEVA, which presents as a recurrent papulonecrotic eruption. The PLC is a cutaneous disease of unknown etiology that most commonly affects children and young adults. The highly variable presentation of this condition often poses a diagnostic challenge. Objective. Presentation of two adults with PLC probably induced by infectious agents. Case reports. A woman presented with scaly, pruritic, erythematous-to-brown flattened papules, which varied in size from 3 mm to 1 cm, on the trunk and extremities, being first diagnosed as guttate psoriasis. A man sought medical advice for a disseminated eruption on the trunk and extremities, observed for 2 months before the consultation. He was in a good medical state, with no comorbidities and no medication. He complained of discrete pruritus and urethral discharge for many days. Conclusions. Pityriasis lichenoides may have arisen secondarily to these infections or there were two simultaneous diseases. Further studies must elucidate the role of infectious agents in this pathology.

  15. Malassezia yeast species isolated from Iranian patients with pityriasis versicolor in a prospective study.

    Science.gov (United States)

    Rasi, Abbas; Naderi, Reza; Behzadi, Ashkan Heshmatzade; Falahati, Mehraban; Farehyar, Shirin; Honarbakhsh, Yasamin; Akasheh, Amir Poya

    2010-07-01

    The goal of this study was to determine the prevalence of Malassezia species in pityriasis versicolor lesions and to examine if the range of species varies with patients characteristics such as: age, sex and family history and also clinical findings such as site and number of the lesions. In a prospective study from July 2006 to July 2007, the patients with a clinical diagnosis of pityriasis versicolor (n = 166) were asked to participate in the study. A total of 116 patients had positive culture for Malassezia species: M. globosa was found in 52 (31.3%) cases, M. furfur in 34 (20.5%) cases, M. pachydermatis in 12 (7.2%) cases, M. restricta in 12 (7.2%) cases, M. slooffiae in 6 (3.6%) cases. According to our data, M. globosa is the main species causing pityriasis versicolor, M. furfur was found to be the second-most frequent species. M. sympodialis and M. obtusa were not found in any case, and in 30.2% of patient's Malassezia culture was negative.

  16. Molecular epidemiology of Malassezia globosa and Malassezia restricta in Sudanese patients with pityriasis versicolor.

    Science.gov (United States)

    Saad, M; Sugita, T; Saeed, H; Ahmed, A

    2013-02-01

    Pityriasis versicolor is a superficial infection of the stratum corneum caused by Malassezia yeasts. The cutaneous Malassezia globosa and Malassezia restricta in Sudanese patients with pityriasis versicolor were elucidated using a molecular-based, culture-independent method and compared with that in healthy individuals. Scale samples were collected by applying an Opsite™ transparent dressing to lesional and non-lesional sites on 29 Sudanese patients with pityriasis versicolor and 54 healthy individuals. Malassezia DNA was extracted directly from the samples. The overall level of colonization by Malassezia globosa and Malassezia restricta was analyzed by real-time PCR using a TaqMan probe. The overall level of colonization by Malassezia at the lesional sites was higher than that at the non-lesional sites for all body sites, including the face, neck, cheeks, and trunk (2.7- to 6.0-fold increase). Both M. globosa and M. restricta were detected in patients and healthy individuals. However, M. globosa predominated at lesional sites, whereas the level of colonization by both species was similar in healthy individuals.

  17. Comparison between fluconazole and ketoconazole effectivity in the treatment of pityriasis versicolor.

    Science.gov (United States)

    Yazdanpanah, Mohammad Javad; Azizi, Hoda; Suizi, Behnaz

    2007-07-01

    Topical drugs are often effective in limited lesions of pityriasis versicolor; but in extensive cases, systemic drugs are more suitable. Previous studies have shown that ketoconazole and fluconazole are effective in 42-97% and 74-100% of lesions respectively. Our purpose was to compare the effectiveness of a single dose of 400 mg ketoconazole with two doses of 300 mg of fluconazole with 2 weeks interval. Ninety patients with extensive pityriasis versicolor (body involved area > or =25%) were randomly assigned to treatment with either a single dose of 400 mg of ketoconazole or with two doses of 300 mg of fluconazole with 2 weeks interval. One month after the treatment, the improvement rate and side effects were evaluated by clinical examination and questionnaire. Sixty cases (66.7%) completed the study. They were 51 males and nine females, with a mean age of 30 years. At the follow-up visit (1 month after the end of treatment), the improvement rate for ketoconazole (87.9%) was not significantly different from fluconazole (81.5%), (Fisher test: P = 0.37). Due to the hepatotoxicity of ketoconazole, fluconazole appears to be more suitable in the treatment of extensive pityriasis versicolor.

  18. Study of the distribution of Malassezia species in patients with pityriasis versicolor and healthy individuals in Tehran, Iran

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    Zeraati Hojjat

    2004-05-01

    Full Text Available Abstract Background Pityriasis versicolor is a superficial infection of the stratum corneum which caused by a group of yeasts formerly named pityrosporium. The taxonomy of these lipophilic yeasts has recently been modified and includes seven species referred as Malassezia. The aim of this study is to compare the distribution of Malassezia species isolated from pityriasis versicolor lesions and those isolated from healthy skins. Methods Differentiation of all malassezia species performed using morphological features and physiological test including catalase reaction, Tween assimilation test and splitting of esculin. Results In pityriasis versicolor lesions, the most frequently isolated species was M. globosa (53.3%, followed by M. furfur (25.3%, M. sympodialis(9.3%, M. obtusa (8.1% and M. slooffiae (4.0%. The most frequently isolated species in the skin of healthy individuals were M. globosa, M. sympodialis, M. furfur, M. sloofiae and M. restricta which respectively made up 41.7%, 25.0%, 23.3%, 6.7% and 3.3% of the isolated species. Conclusions According to our data, M. globosa was the most prevalent species in the skin of healthy individuals which recovered only in the yeast form. However, the Mycelial form of M. globosa was isolated as the dominant species from pityriasis versicolor lesions. Therefore, the role of predisposing factors in the conversion of this yeast to mycelium and its subsequent involvement in pityriasis versicolor pathogenicity should be considered.

  19. A Randomized, Double-blind, Placebo-Controlled Study of Efficacy of Oral Acyclovir in the Treatment of Pityriasis Rosea.

    Science.gov (United States)

    Ganguly, Satyaki

    2014-05-01

    Pityriasis rosea is an acute self-limiting skin disorder of unknown aetiology. Recently human herpes virus 6 and 7 has been hypothesized to be the cause of pityriasis rosea. To determine the efficacy of acyclovir, an anti-viral drug, in the treatment of pityriasis rosea. A randomized, double-blind, placebo-controlled study of efficacy of oral acyclovir in the treatment of pityriasis rosea was conducted on 73 patients. Thirty eight randomly selected patients were started on oral acyclovir. Thirty-five patients were prescribed placebo. The patients as well as the chief investigator were unaware of the therapeutic group to which patients belonged (acyclovir or placebo). Patients in both the groups were evaluated clinically after 7 and 14 days following the first visit and the data were analysed. Follow up data of 60 patients was available and these were included in the statistical analysis. 53.33% and 86.66% of the patients belonging to the acyclovir group showed complete resolution on the 7(th) day and 14(th) day respectively following the first visit compared to 10% and 33.33% of patients from the placebo group. The findings were statistically significant. The study showed that high dose acyclovir is effective in the treatment of pityriasis rosea.

  20. [Missing granulocytic infiltrate in pityriasis versicolor--indication of specific anti-inflammatory activity of the pathogen?].

    Science.gov (United States)

    Wroblewski, N; Bär, Silja; Mayser, P

    2005-01-01

    The yeast Malassezia furfur is a part of the resident flora of human skin. It causes various diseases such as pityriasis versicolor, which hardly shows signs of inflammation despite marked clinical symptoms (e.g. hypopigmentation). The pathophysiology related morphological picture might give a clue to this phenomenon. As a part of the literature data are controversial, the present study compared the inflammatory infiltrate of pityriasis versicolor with that of tinea corporis in 40 human skin preparations each from diagnostic specimens. All preparations were stained with HE and PAS. Neutrophilic granulocytes were counted in the HE stain, and hyphae and spores in the PAS stain. The number of counted cells was related to the size of the respective area and the values were compared between pityriasis and tinea corporis. Significantly, more neutrophilic granulocytes were found with tinea corporis (P > 0.01), while they were virtually not demonstrable with pityriasis versicolor. It is surprising that fungal load in the stratum corneum is significantly higher with pityriasis versicolor (P > 0.01). Obviously the immune response involving neutrophilic granulocytes does not occur despite high bacterial load. This might be explained by reduced immunogenicity because of high content of lipids in the cell membrane. Furthermore, pityriarubins that are produced during tryptophan metabolism might be involved, which, in a stimulus-dependent manner, can suppress the ROS production of neutrophilic granulocytes in vivo.

  1. Pityriasis lichenoides: a clonal T-cell lymphoproliferative disorder.

    Science.gov (United States)

    Magro, Cynthia; Crowson, A Neil; Kovatich, Al; Burns, Frank

    2002-08-01

    Pityriasis lichenoides (PL) is a papulosquamous disorder often considered a form of reactive dermatosis and classified with small plaque parapsoriasis (digitate dermatosis). However, some patients with PL have developed large plaque parapsoriasis (LPP) and mycosis fungoides (MF), and lymphoid atypia and T-cell clonality have been reported in lesions of PL. We set out to explore the possibility that PL is a form of T-cell dyscrasia. Cases were selected by natural language search from an outpatient dermatopathology database; 35 cases were reviewed and clinicians and patients were contacted. Hematoxylin and eosin-stained sections were examined and immunophenotyping was carried out on paraffin-embedded, formalin-fixed tissue using antibodies to CD2, CD3, CD4, CD5, CD7, CD8, CD20, CD30, and CD56. In paraffin-embedded tissue, T-cell receptor (TCR)-gamma chain rearrangement was sought through polymerase chain reaction single stranded conformational polymorphism analysis. There were 14 males and 21 females with a mean age of 40 years held clinically to have PL chronica (PLC) (28 cases) and/or PL et varioliformis acuta (PLEVA) (7 cases). Five patients developed large atrophic poikilodermatous and/or annular plaques compatible with MF and/or LPP in a background of typical PLC. All biopsies showed tropism of lymphocytes to an epidermis manifesting psoriasiform hyperplasia, dyskeratosis, parakeratosis, and intraepithelial collections of Langerhans' cells and lymphocytes mimicking Pautrier's microabascesses. Epidermal atrophy, dermal fibroplasia, poikilodermatous alterations, and a dominance of intraepidermal cerebriform cells were seen only in patients with chronic persistent disease (i.e., PLC) and in some cases corresponded with clinical progression to MF. All cases had a T cell-dominant infiltrate, with a CD7 deletion in 21 of 32 biopsies examined; the CD7-negative cells were typically the largest and most atypical forms, often in a cohesive array within the upper layers of

  2. Therapeutic hotline. Effectiveness of the association of cetirizine and topical steroids in lichen planus pilaris--an open-label clinical trial.

    Science.gov (United States)

    d'Ovidio, Roberto; Rossi, Alfredo; Di Prima, Tiziana Maria

    2010-01-01

    Lichen planus is considered a T cell-mediated immunological disease. Even mast cells may contribute to the pathogenesis of the disease. Keratinocytes of the basal layer of the skin and/or the hair follicle may represent the "target/victim" of an immune aggression, determining the destruction of the hair follicle and thus scarring alopecia. Therefore, there is a compelling urgency for effective treatment of this potentially disfiguring dermatosis. Our data provide a further therapeutic opportunity: the use of an antihistaminic drug--cetirizine (CTZ)--in an "anti-inflammatory" regimen. We propose the use of CTZ at the dosage of 30 mg/daily. Twenty-one patients affected by lichen planus pilaris (LPP) of the scalp have been treated. Topical application of steroids has been coadministered in all cases during the therapy. Clinical effects, in the sense of stabilization with cessation of the inflammation (erythema, follicular hyperkeratosis, loss of anagen hair), were achieved in all patients but three. One patient developed cardiac arrhythmia after 3 months of successful treatment and dropped out. Our cases indicate that a combined therapy of topical steroid with CTZ can be a safe and effective choice even in severe cases of lichen planus pilaris, so often refractory to the therapy. © 2010 Wiley Periodicals, Inc.

  3. Studies upon morhological and biological traits of Festuca rubra, subsp.fallax (Poaceae

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    Bogusław Sawicki

    2013-12-01

    Full Text Available Observation and measurements of some traits of Festuca rubra L., subsp. fallax (Thuill. Hack. ecotypes were made in 1995-1997 using samples selected from natural habitats and collected in Grassland Experimental Station in Sosnowica. High differentiation of traits under study and their correlations were found. Valorized ecotypes are good material for new varieties breeding.

  4. Application of near-infrared spectroscopy for the rapid quality assessment of Radix Paeoniae Rubra

    Science.gov (United States)

    Zhan, Hao; Fang, Jing; Tang, Liying; Yang, Hongjun; Li, Hua; Wang, Zhuju; Yang, Bin; Wu, Hongwei; Fu, Meihong

    2017-08-01

    Near-infrared (NIR) spectroscopy with multivariate analysis was used to quantify gallic acid, catechin, albiflorin, and paeoniflorin in Radix Paeoniae Rubra, and the feasibility to classify the samples originating from different areas was investigated. A new high-performance liquid chromatography method was developed and validated to analyze gallic acid, catechin, albiflorin, and paeoniflorin in Radix Paeoniae Rubra as the reference. Partial least squares (PLS), principal component regression (PCR), and stepwise multivariate linear regression (SMLR) were performed to calibrate the regression model. Different data pretreatments such as derivatives (1st and 2nd), multiplicative scatter correction, standard normal variate, Savitzky-Golay filter, and Norris derivative filter were applied to remove the systematic errors. The performance of the model was evaluated according to the root mean square of calibration (RMSEC), root mean square error of prediction (RMSEP), root mean square error of cross-validation (RMSECV), and correlation coefficient (r). The results show that compared to PCR and SMLR, PLS had a lower RMSEC, RMSECV, and RMSEP and higher r for all the four analytes. PLS coupled with proper pretreatments showed good performance in both the fitting and predicting results. Furthermore, the original areas of Radix Paeoniae Rubra samples were partly distinguished by principal component analysis. This study shows that NIR with PLS is a reliable, inexpensive, and rapid tool for the quality assessment of Radix Paeoniae Rubra.

  5. Myrionecta Rubra Population Genetic Diversity and Its Cryptophyte Chloroplast Specificity in Recurrent Red Tides in the Columbia River Estuary

    Energy Technology Data Exchange (ETDEWEB)

    Herfort, Lydie; Peterson, Tawnya D.; McCue, Lee Ann; Crump, Byron C.; Prahl, Fredrick G.; Baptista, Antonio M.; Campbell, Victoria; Warnick, Rachel; Selby, Mikaela; Roegner, G. Curtis; Zuber, Peter A.

    2011-01-04

    For at least a decade, annually recurring blooms of the photosynthetic ciliate, Myrionecta rubra have been observed in the Columbia River estuary in late summer. In an effort to understand the dynamics of these blooms, we investigated the genetic variability of M. rubra and its cryptophyte plastids within three large estuarine blooms formed in consecutive years (2007-2009), and conducted a broader spatial survey along the coasts of Oregon/Washington. Analysis of the ‘18S-28S’ sequences specific for Mesodiniidae uncovered at least 7 variants of M. rubra within the Columbia River coastal margin in spring and summer, but only one of these M. rubra variants was implicated in estuary bloom formation. Using a multigene approach, we show that the bloom-forming variant of M. rubra appears to harbor the same cryptophyte chloroplast in recurring blooms. Analyses of chloroplast 16S rRNA, cryptophyte RuBisCO and Photosystem II D2 genes together suggest that the plastid is derived from Teleaulax amphioxeia. Free-living cells of this species and of other cryptophytes were practically absent from the bloom patches in the estuary main channels based on 18S rDNA sequence analyses. The respectively low and high proportions of T. amphioxeia nuclei and chloroplasts signals found in the M. rubra bloom of the Columbia River estuary in successive years supports the notion of a transient association between T. amphioxeia and the bloom-forming M. rubra variant, with loss of cryptophyte nuclei. The genetic variability of M. rubra uncovered here is relevant to the controversy in the literature regarding the cryptophyte /M. rubra association.

  6. 15-demethylisoplumieride acid, a new iridoid isolated from the bark of Plumeria rubra and latex of Himatanthus sucuuba; Acido 15-desmetilisoplumierideo, um novo iridoide isolado das cascas de Plumeria rubra e do latex de Himatanthus sucuuba

    Energy Technology Data Exchange (ETDEWEB)

    Barreto, Alaide de Sa; Amaral, Ana Claudia F. [Fundacao Inst. Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, RJ (Brazil). Instituto de Tecnologia em Farmacos -Farmanguinhos. Lab. de Plantas Medicinais e Derivados; Silva, Jefferson Rocha de A. [Universidade Federal do Amazonas, Manaus, AM (Brazil). Dept. de Quimica]. E-mail: jrocha_01@ufam.edu.br; Schripsema, Jan [Universidade Estadual do Norte Fluminense (UENF), Campos dos Goytacazes, RJ (Brazil). Setor de Quimica de Produtos Naturais; Rezende, Claudia M.; Pinto, Angelo C. [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Inst. de Quimica

    2007-09-15

    Himatanthus sucuuba and Plumeria rubra are used in folk medicine in Brazil to treat various ailments. The isolation of the new iridoid 15-demethylisoplumieride from the bark of Plumeria rubra L. var. acutifolia (Ait) Woodson and latex of Himatanthus sucuuba (Spruce) Woodson is reported. Other iridoid glycosides were obtained from both plants. The structures of these substances were elucidated by spectral analysis and comparison with data already reported. (author)

  7. Fungal Endophyte (Epichloë festucae) Alters the Nutrient Content of Festuca rubra Regardless of Water Availability

    OpenAIRE

    Vázquez-de-Aldana, Beatriz R; Antonia García-Ciudad; Balbino García-Criado; Santiago Vicente-Tavera; Iñigo Zabalgogeazcoa

    2013-01-01

    Festuca rubra plants maintain associations with the vertically transmitted fungal endophyte Epichloë festucae. A high prevalence of infected host plants in semiarid grasslands suggests that this association could be mutualistic. We investigated if the Epichloë-endophyte affects the growth and nutrient content of F. rubra plants subjected to drought. Endophyte-infected (E+) and non-infected (E-) plants of two half-sib lines (PEN and RAB) were subjected to three water availability treatments. S...

  8. Pityriasis Alba--Common Disease, Enigmatic Entity: Up-to-Date Review of the Literature.

    Science.gov (United States)

    Miazek, Nina; Michalek, Irmina; Pawlowska-Kisiel, Malgorzata; Olszewska, Malgorzata; Rudnicka, Lidia

    2015-01-01

    Pityriasis alba (PA) is a skin disorder that affects children and adolescents. Although it is common worldwide, its incidence is markedly higher in darker skin phototypes. Its characteristic features include an extended, multistage course and spontaneous remissions and recurrences. Preceded by erythematous changes, patches of hypopigmented skin of up to a few centimeters in diameter appear on the upper body. Pruritus may accompany it. Even though its etiology is unknown, possible reported triggering factors include sunlight, beauty treatments, and microorganisms, among others. Calcineurin inhibitors play the most crucial role in PA pharmacotherapy. PA often coexists with atopic dermatitis and is considered one of its milder forms.

  9. Pityriasis Rosea with Erythema Multiforme – Like Lesions: An Observational Analysis

    Science.gov (United States)

    Relhan, Vineet; Sinha, Surabhi; Garg, Vijay K; Khurana, Nita

    2013-01-01

    Pityriasis rosea (PR) is an acute or subacute inflammatory skin disease characterized by erythematous papulosquamous eruptions localized on the trunk and arms. The eruptions are self-limiting and usually disappear gradually in 2-10 weeks, without any treatment. Typical PR is much easier to diagnose than the rare atypical forms. There is a passing mention of PR with erythema multiforme-like lesions in the literature, but no extensive case series have been published till date. We present a series of five patients for whom we believe atypical PR is the likely diagnosis. PMID:23723495

  10. Lichen striatus and pityriasis lichenoides chronica in an 11-year-old girl: An etiologic relationship?

    Science.gov (United States)

    Erpolat, Seval; Yenidunya, Sibel

    2015-09-01

    Lichen striatusis a rare linear papulardermatosis that primarily occurs in children. The lesions have a linear distribution following Blaschko's lines. Pityriasis lichenoides is an uncommon benign skin disorder with two major variants: acute and chronic.Herein, we report the case of an 11-year-old girl with concurrent pityriasisli chenoides chronica and lichen striatus, a previously unreported association. Although it remains unclear whether there is an aetiological relationship between the two diseases or whether their coexistence was coincidental in our patient, but some common mechanisms may be involved in the two diseases.

  11. Non-acne dermatologic indications for systemic isotretinoin.

    Science.gov (United States)

    Akyol, Melih; Ozçelik, Sedat

    2005-01-01

    Systemic isotretinoin has been used to treat severe acne vulgaris for 20 years. However, isotretinoin also represents a potentially useful choice of drugs in many dermatologic diseases other than acne vulgaris. Diseases such as psoriasis, pityriasis rubra pilaris, condylomata acuminata, skin cancers, rosacea, hidradenitis suppurativa, granuloma annulare, lupus erythematosus and lichen planus have been shown to respond to the immunomodulatory, anti-inflammatory and antitumor activities of the drug. Isotretinoin also helps prevent skin cancers such as basal cell carcinoma or squamous cell carcinoma. A combination of systemic isotretinoin and interferon-alpha-2a may provide a more potent effect than isotretinoin alone in the prevention and treatment of skin cancers.Systemic isotretinoin may be considered as an alternative drug in some dermatologic diseases unresponsive to conventional treatment modalities. However, randomized clinical trials aimed at determining the role of systemic isotretinoin therapy in dermatologic diseases other than acne vulgaris are required.

  12. Intraspecific Variation in Maximum Ingested Food Size and Body Mass in Varecia rubra and Propithecus coquereli

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    Adam Hartstone-Rose

    2011-01-01

    Full Text Available In a recent study, we quantified the scaling of ingested food size (Vb—the maximum size at which an animal consistently ingests food whole—and found that Vb scaled isometrically between species of captive strepsirrhines. The current study examines the relationship between Vb and body size within species with a focus on the frugivorous Varecia rubra and the folivorous Propithecus coquereli. We found no overlap in Vb between the species (all V. rubra ingested larger pieces of food relative to those eaten by P. coquereli, and least-squares regression of Vb and three different measures of body mass showed no scaling relationship within each species. We believe that this lack of relationship results from the relatively narrow intraspecific body size variation and seemingly patternless individual variation in Vb within species and take this study as further evidence that general scaling questions are best examined interspecifically rather than intraspecifically.

  13. The negative impact of intentionally introduced Quercus rubra L. on a forest community

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    Beata Woziwoda

    2014-03-01

    Full Text Available Some alien woody species used in commercial forestry become invasive and, as invaders, cause major problems in natural and semi-natural ecosystems. However, the deliberate introduction of aliens can bring unintended negative changes also within areas of their cultivation. This paper presents the effects of the intentional introduction of the North-American Quercus rubra in European mixed Scots pine-Pedunculate oak forests (POFs: Querco roboris-Pinetum (W. Mat. 1981 J. Mat. 1988. Phytosociological data from field research combined with GIS data analysis of the current distribution of Northern Red oak in the studied habitat were used to determine the composition and structure of forest communities in plots with and without Q. rubra participation.  The results show that Q. rubra significantly reduces native species richness and abundance, both in old-growth and in secondary (post-agricultural forests. Not one resident vascular plant benefits from the introduction of Northern Red oak and only a few are able to tolerate its co-occurrence. The natural restocking of all native woody species is also strongly limited by this alien tree.  The introduction of Northern Red oak significantly limits the environmental functions of the POF ecosystem and weakens its economic and social aspects. However, its further cultivation is justified from an economic point of view, as the essential function of the studied forests is commercial timber production, and the introduction of this fast growing alien tree supports the provisioning ecosystem services. A clear description of the level of trade-off between the accepted negative and positive effects of the introduction of Q. rubra on forest ecosystem services requires further interdisciplinary studies.

  14. Influence of the soil Ca on the tolerance of Festuca rubra populations against toxic metals

    Energy Technology Data Exchange (ETDEWEB)

    Karataglis, S.S.

    1981-02-15

    Festuca rubra populations from toxic or non-toxic areas were studied. Their tolerance against the soil content in toxic metals and in combination with the Ca content was also correlated. It was demonstrated that the Festuca rubra populations developed in an environment with high concentrations of toxic metals and with high concentrations of Ca at the same time, showed very little or almost no tolerance against these metals. On the contrary, populations from other mines with normal Ca concentrations in their soil indicated increased tolerance against the toxic metals found in it. This behaviour expressed by the Festuca rubra populations of the Ecton mine is probably due to the high Ca concentration found in the soil in the form of CaCO/sub 2/. CaCO/sub 3/ along with the heavy metals has the ability to form undissolved or not easily dissolved carbonate salts. As a result there are no free ions of toxic metals in the immediate environment of the root and consequently the plants cannot be selected against these metals.

  15. EFEITO ALELOPÁTICO E MOLUSCICIDA DE AMORA (Morus rubra L.

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    ANA CRISTINA MENDES MIRANDA

    2012-01-01

    Full Text Available Secondary metabolite produced in some plants can provoke alterations in the development of other plants or even other organisms. The aim of this paper was to identify possible allelopathic effects and biologic control of Achatina fulica Bowdich with aqueous extracts of Morus rubra L. leaves. For obtaining the aqueous extract, we used previously dried leaves in concentration of 1g 10 mL-1. Five concentrations of each aqueous extract were tested (10, 30, 50, 70 and 100% and compared to control (0.0%, distilled water. The aqueous extracts of Morus rubra showed up allelopathic potentialities on the seed germination and in the growth of the shoot and the root system of the tested species, considering that the reduction in the germination and initial growth increased with the rising of the aqueous extracts concentrations used and, in the biologic control, only in the final mass of A. fulica. The results indicated the existence of allelopathic effect, but not molluscicide of M. rubra.

  16. The Role of Biopsy in Pediatric Dermatopathology

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    Fatma Şule Afşa

    2011-09-01

    Full Text Available Background and Design: Pediatric dermatology is characterized by skin disorders which have frequencies different from those in adults. Skin biopsies are necessary for differential diagnosis and clinicopathologic correlation is very important. The aim of this study was to evaluate retrospectively the pediatric dermatology cases in whom biopsy was performed for differential diagnosis and to investigate the contribution of biopsy to diagnosis of skin disorders. Material and Methods: The cases from whom biopsy was taken in the pediatric dermatology clinic during a three-year period were evaluated retrospectively for pre-diagnoses, biopsy diagnoses, and success of biopsies.Results: Two hundred thirteen (1.7% skin biopsies had been taken from a total of 12420 patients. Henoch-Schönlein purpura, psoriasis, pityriasis lichenoides, pityriasis rosea, lichen planus, pityriasis rubra pilaris, erythema multiforme, atopic dermatitis, granuloma annulare, and pigmented purpuric dermatosis were the most frequent skin disorders diagnosed dermatopathologically. In a total of 120 (56.3% cases, the biopsy diagnosis was within the pre-diagnosis and a biopsy consistency was present. In 25 (11.7% cases, biopsy had no contribution to the differential diagnosis. An absolutely different diagnosis which was incompatible with the pre-diagnosis had been reported in 10 (4.6% cases. Conclusion: In pediatric dermatology, skin biopsy is very helpful for the differential diagnosis. An easy biopsy procedure for the patient, an effective designation of biopsy indication, a good dermatopathologic correlation and an experienced team of pediatric dermatopathology increase the success of skin biopsies.

  17. Humoral immunity to Malassezia furfur serovars A, B and C in patients with pityriasis versicolor, seborrheic dermatitis and controls.

    Science.gov (United States)

    Ashbee, H R; Fruin, A; Holland, K T; Cunliffe, W J; Ingham, E

    1994-10-01

    This study examined the humoral immune responses to Malassezia furfur serovars A, B and C of 10 patients with pityriasis versicolor, 10 patients with seborrheic dermatitis and 20 age- and sex-matched controls. A transferable solid-phase ELISA was used to determine titres of total Igs, IgM, IgA and IgG specific to M. furfur serovars A, B and C. The results demonstrated that patients with seborrheic dermatitis had a significantly higher titre of total Igs to serovar A than patients with pityriasis versicolor; and that patients with seborrheic dermatitis had a significantly higher titre of IgA to serovar C than patients with pityriasis versicolor. The titres of total Igs for controls and patients with seborrheic dermatitis were significantly lower to serovar B than to serovar C. A modified TSP ELISA was used to determine the titres of the IgG subclasses. Titres of IgG1,3,4 to serovar B were significantly higher in seborrheic dermatitis patients than pityriasis versicolor patients and titres of IgG3 to serovar A were significantly higher in seborrheic dermatitis patients than pityriasis versicolor patients. However, despite the differences between the patient groups, none of these results was significantly different to those of controls. Thus, this study did not demonstrate any differences in humoral immunity of patients suffering from Malassezia-associated dermatoses when compared to normal controls. These results may suggest that the humoral immune response to M. furfur is not related to the pathogenesis of Malassezia-associated dermatoses, but simply to the carriage of M. furfur on the skin.

  18. Expression of antimicrobial peptides and toll-like receptors is increased in tinea and pityriasis versicolor.

    Science.gov (United States)

    Brasch, J; Mörig, A; Neumann, B; Proksch, E

    2014-03-01

    In superficial tinea and pityriasis versicolor, the causative fungi are for the most part confined to the stratum corneum which is barely reached by leukocytes. Therefore, a role of non-cellular components in the epidermal antifungal defence was suggested. To investigate the presence of such factors in these infections, the expression of human beta defensins 2 and 3 (hBD-2, hBD-3), RNase 7, psoriasin, toll-like receptors 2, 4 and 9 (TLR2, TLR4 and TLR9) and dectin 2 was analysed by use of immunostainings in skin biopsies. We found that hBD2, hBD3, psoriasin, RNase7, TLR2 and TLR4 were significantly more often expressed in distinct layers of lesional epidermis as compared with uninfected epidermis. In both infections but not in normal skin, hBD2 and hBD3 were commonly expressed within the stratum corneum and in the stratum granulosum. Similarly, psoriasin was seen more often in the upper skin layers of both infections as compared with normal skin. No significant differences between normal and infected skin were found for the expression of TLR9 and dectin 2. Our findings clearly show the expression of specific antimicrobial proteins and defence-related ligands in superficial tinea as well as in pityriasis versicolor, suggesting that these factors contribute to fungal containment. © 2013 Blackwell Verlag GmbH.

  19. Distribution of Malassezia species in patients with pityriasis versicolor in Northern Iran

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    Shokohi T

    2009-01-01

    Full Text Available Purpose : Malassezia yeasts are globally distributed agents of pityriasis versicolor and are implicated in the pathogenesis of seborrhoeic and atopic dermatitis. The aim of this study is to identify the Malassezia species obtained from pityriasis versicolor patients, using morphological, biochemical, physiological as well as Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP methods. Materials and Methods: The identification of Malassezia species is performed according to microscopic features and physiological characteristics, including catalase reaction and Tween assimilation tests. The DNA is extracted from cultured Malassezia using the glass bead, phenol-chloroform method. The internal transcribed spacer 1(ITS1 region is amplified and there is restricted digestion of the PCR products with two enzymes Cfo I and Bst F5I. Results : The most commonly isolated species is M. globosa (47.6%. RFLP analysis of the PCR products of the ITS1 region is in complete agreement with those from the DNA sequences of the internal transcribed spacer (ITS 1 region and the biochemical tests. Conclusion : Based on the findings of this study, it can be concluded that PCR-RFLP is a relatively simple and quick method, completely comparable to the routine methods used for Malassezia identification.

  20. [Metabolomics study of anti-platelet effect of Radix Paeoniae Rubra and Radix Paeoniae Alba by UPLC-MS].

    Science.gov (United States)

    Yang, Qiwei; Yang, Li; Xiong, Aizhen; Wang, Rui; Wang, Zhengtao

    2011-03-01

    To study the anti-platelet effect and influence of Radix Paeoniae Rubra and Radix Paeoniae Alba on rat's endogenous metabolites by animal experiment and UPLC-MS based metabolomic method. After administration of 80% ethanol extracts of Radix Paeoniae Rubra and Radix Paeoniae Alba for 6 d, the serum samples were analyzed by ultra-performance liquid chromatography- mass spectrometry (UPLC-MS) and partial least squares-discriminant analysis (PLS-DA) to find out the potential biomarker. Both of the extracts of Radix Paeoniae Rubra and Radix Paeoniae Alba have good effects of inhibition on platelet coacervation, and the effect of Radix Paeoniae Alba is better than that of Radix Paeoniae Rubra. Malic acid, alpha-acetone dicarboxylic acid, leukotrieneA4 (LTA4), prostaglandinE2 (PGE2) and prostaglandin F2alpha (PGF2alpha) are proved to be significant expressed biomarkers. Metabolomics is helpful for the further research of the mechanism of anti-platelet action of Radix Paeoniae Rubra and Radix Paeoniae Alba.

  1. Essential Oil from Myrica rubra Leaves Potentiated Antiproliferative and Prooxidative Effect of Doxorubicin and its Accumulation in Intestinal Cancer Cells.

    Science.gov (United States)

    Ambrož, Martin; Hanušová, Veronika; Skarka, Adam; Boušová, Iva; Králová, Věra; Langhasová, Lenka; Skálová, Lenka

    2016-01-01

    Essential oil from the leaves of Myrica rubra, a subtropical Asian fruit tree traditionally used in folk medicines, has a significant antiproliferative effect in several intestinal cancer cell lines. Doxorubicin belongs to the most important cytostatics used in cancer therapy. The present study was designed to evaluate the effects of defined essential oil from M. rubra leaves on efficacy, prooxidative effect, and accumulation of doxorubicin in cancer cell lines and in non-cancerous cells. For this purpose, intestinal adenocarcinoma CaCo2 cells were used. Human fibroblasts (periodontal ligament) and a primary culture of rat hepatocytes served as models of non-cancerous cells. The results showed that the sole essential oil from M. rubra has a strong prooxidative effect in cancer cells while it acts as a mild antioxidant in hepatocytes. Combined with doxorubicin, the essential oil enhanced the antiproliferative and prooxidative effects of doxorubicin in cancer cells. At higher concentrations, synergism of doxorubicin and essential oil from M. rubra was proved. In non-cancerous cells, the essential oil did not affect the toxicity of doxorubicin and the doxorubicin-mediated reactive oxygen species formation. The essential oil increased the intracellular concentration of doxorubicin and enhanced selectively the doxorubicin accumulation in nuclei of cancer cells. Taken together, essential oil from M. rubra leaves could be able to improve the doxorubicin efficacy in cancer cells due to an increased reactive oxygen species production, and the doxorubicin accumulation in nuclei of cancer cells.

  2. Pityriasis lichenoides et varioliformis acuta in skin of color: new observations by dermoscopy

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    Ankad, Balachandra S.; Beergouder, Savitha L.

    2017-01-01

    Background Pityriasis lichenoides is an uncommon skin disease that presents in three different forms: pityriasis lichenoides et varioliformis acuta (PLEVA), pityriasis lichenoides chronica (PLC) and febrile ulceronecrotic-Mucha-Habermann disease. These represent a spectrum of a disease. PLEVA presents as skin eruption of multiple, small, red papules that develop into polymorphic lesions with periods of varying remissions, as well as possible sequels of hyper/hypopigmentation and varicella-like scars. Diagnosis of this condition is mainly clinical, and sometimes clinical differentiation from other conditions may be a difficult task that often requires histological analysis. In this study, PLEVA lesions were examined by dermoscopy, and the significance of specific dermoscopic findings was investigated in order to facilitate their differentiation from other inflammatory conditions. Objectives To evaluate dermoscopic patterns in PLEVA and to correlate these patterns with histopathology. Materials and methods The study was conducted at S. Nijalingappa Medical College, Bagalkot. It was an observational case series study and patients were selected randomly. Ethical clearance and informed consent were obtained. PLEVA lesions in early and late phases were evaluated. A manual DermLite 3 (3Gen, San Juan Capistrano, CA) dermoscope attached to a Sony (Cyber Shot DSC-W800, Sony Electronics Inc., San Diego, California, USA, digital, 14 mega pixels) camera was employed. Histopathology was done to confirm the diagnosis. Data was collected and analyzed. Results were statistically described in terms of frequencies and types of dermoscopic patterns. Results There was a total of 14 patients; 8 males and 6 females. Mean age of patients was 19 years. Mean duration of disease was 7 months. Dermoscopy in early-phase lesions revealed amorphous brownish areas around the hair follicles, dotted vessels, and scaling. Dermoscopy in late-phase lesions showed whitish-structureless areas and

  3. Pityriasis lichenoides et varioliformis acuta in skin of color: new observations by dermoscopy.

    Science.gov (United States)

    Ankad, Balachandra S; Beergouder, Savitha L

    2017-01-01

    Pityriasis lichenoides is an uncommon skin disease that presents in three different forms: pityriasis lichenoides et varioliformis acuta (PLEVA), pityriasis lichenoides chronica (PLC) and febrile ulceronecrotic-Mucha-Habermann disease. These represent a spectrum of a disease. PLEVA presents as skin eruption of multiple, small, red papules that develop into polymorphic lesions with periods of varying remissions, as well as possible sequels of hyper/hypopigmentation and varicella-like scars. Diagnosis of this condition is mainly clinical, and sometimes clinical differentiation from other conditions may be a difficult task that often requires histological analysis. In this study, PLEVA lesions were examined by dermoscopy, and the significance of specific dermoscopic findings was investigated in order to facilitate their differentiation from other inflammatory conditions. To evaluate dermoscopic patterns in PLEVA and to correlate these patterns with histopathology. The study was conducted at S. Nijalingappa Medical College, Bagalkot. It was an observational case series study and patients were selected randomly. Ethical clearance and informed consent were obtained. PLEVA lesions in early and late phases were evaluated. A manual DermLite 3 (3Gen, San Juan Capistrano, CA) dermoscope attached to a Sony (Cyber Shot DSC-W800, Sony Electronics Inc., San Diego, California, USA, digital, 14 mega pixels) camera was employed. Histopathology was done to confirm the diagnosis. Data was collected and analyzed. Results were statistically described in terms of frequencies and types of dermoscopic patterns. There was a total of 14 patients; 8 males and 6 females. Mean age of patients was 19 years. Mean duration of disease was 7 months. Dermoscopy in early-phase lesions revealed amorphous brownish areas around the hair follicles, dotted vessels, and scaling. Dermoscopy in late-phase lesions showed whitish-structureless areas and central white crust within whitish-structureless rim with

  4. COMPARATIVE ANTIOXIDANT ACTIVITY OF BERRIES OF MORUS MGRA L., MORUS ALBA L. AND MORUS RUBRA L.

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    Yu. A. Vakhrusheva

    2015-01-01

    Full Text Available The article discusses the results of antiox-idaut activity of berries extract of Moms nigra L., Moras alba L., and Moras rubra L. We have studied the total content of antioxidants in the extract of these species beiiies using liquid chromotographer "Tsvet Yauza-01-AA". Aniperometric method was used for measuring of mass concentration of antioxidants. We determined the quantity of antioxidants using analytical curve of dependence of exit signal on the quercetine and gallic acid concentration. The study resulted on the revelation of antioxidant content in alcohol, water-alcohol, and water extracts from the objects of study mentioned above

  5. The breeding system of wild red ruffed lemurs (Varecia rubra): a preliminary report.

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    Vasey, Natalie

    2007-01-01

    Captive studies have shown that ruffed lemurs (Varecia) have an unusual suite of reproductive traits combined with extremely high maternal reproductive costs. These traits include the bearing of litters, nesting of altricial young, and absentee parenting. To characterize the breeding system of this enigmatic lemur, reproductive traits must be contextualized in the wild. Here, I provide a preliminary report of mating and infant care in one community of wild red ruffed lemurs (Varecia rubra). Observations span a 15-month period covering two birth seasons and one mating season on the Masoala Peninsula, Madagascar. Factors that are not possible to replicate in captivity are reported, such as mating pattern, natality and mortality rates, the location of nests within the home range, and the structuring of infant care within a natural community. V. rubra at Andranobe have a fission-fusion, multifemale-multimale grouping pattern and a polygamous mating system. They do not mate monogamously or live strictly in family-based groups as suggested by previous workers. During the first 2 months of life, nests and infant stashing localities are situated within each mother's respective core area, and inhabitants of each core area within the communal home range provide care for young. As part of their absentee parenting system, infants are left in concealed, protected, and supportive spots high in the canopy, while mothers travel distantly. This practice is termed 'infant stashing'. Alloparenting appears to be an integral part of V. rubra's overall reproductive strategy in the wild, as it was performed by all age-sex classes. Among the alloparental behaviors observed were infant guarding, co-stashing, infant transport, and allonursing. Alloparenting and absentee parenting may mitigate high maternal reproductive costs. Furthermore, V. rubra may have a breeding system in which genetic partners (i.e., mating partners) do not always correspond to infant care-providers. Combined with

  6. Pityriasis rosea-like drug eruption due to bupropion: a case report.

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    Polat, M; Uzun, Ö; Örs, I; Boran, Ç

    2014-12-01

    Pityriasis rosea (PR) is a common, acute, and self-limited inflammatory skin disease. The typical clinical presentation includes the appearance of a primary "herald" patch followed within days to weeks by the onset of secondary scaly skin eruptions distributed along the skin tension line in most cases. Although PR is a well-known and relatively common disease, its cause is still not completely understood. However, viral agents, autoimmunity, psychogenic status, and numerous drugs have been proposed as possible factors to PR. Bupropion is known to cause hypersensitivity reactions. We present a clinical case of PR eruption caused by the use of bupropion. To the best of our knowledge, this is the first published case of PR associated with bupropion use. © The Author(s) 2014.

  7. Comparative study of ketoconazole versus selenium sulphide shampoo in pityriasis versicolor

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    Aggarwal K

    2003-03-01

    Full Text Available Forty patients suffering from pityriasis versicolor were treated with either 2% ketoconazole shampoo (20 patients or 2.5% selenium sulphide shampoo (20 patients, once a week for three weeks. On global assessment after one month of start of therapy, 19 (95% out of 20 patients treated with ketoconazole shampoo were cured while one case had mild residual disease. In selenium sulphide shampoo group, 17 (85% out of 20 patients were cured, one had mild residual disease and two had considerable residual disease. No significant difference was observed in the response rates in the two groups. Relapse occurred in one patient of ketoconazole group and two patients of selenium sulphide group during the follow - up period of three months.

  8. Comparative clinicopathological study on pityriasis lichenoides chronica and small plaque parapsoriasis.

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    Benmamán, O; Sánchez, J L

    1988-06-01

    The term parapsoriasis refers to a group of chronic asymptomatic scaly dermatoses of unknown etiology about which there is still controversy over the nosology and nomenclature of the different conditions that comprise the group, particularly pityriasis lichenoides chronica (PLC) and small plaque parapsoriasis (SPP). In an attempt to establish the distinctive clinicopathologic features of these two dermatosis, we prospectively studied 44 patients who presented with the typical clinical and histologic picture of either of these two diseases. SPP was clinically characterized by scaly oval plaques on the trunk and proximal aspect of extremities. Spongiosis was the salient histopathologic feature, with absence of fibrosis or melanophages. PLC presented with a scaly papular eruption over the trunk and extremities and histologically was characterized by an interface dermatitis. We conclude that sufficient clinical and histologic features differentiate these two entities and we propose that the term parapsoriasis be used only to designate SPP and large plaque parapsoriasis.

  9. Evaluation of Demographics and Climatic Factors/Disease Relationship in Patients with Pityriasis Rosea

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    Emel Bülbül Başkan

    2011-06-01

    Full Text Available Background and Design: Pityriasis rosea (PR is an acute onset, self-limiting papulosquamous skin disease. The etiology of the disease is totally unknown, however, many epidemiological and clinical studies have suggested that infectious agents may cause the disease. Seasonal changes in the incidence may be an epidemiologic evidence for potential infectious etiology. In this study, we aimed to analyze the demographic data of PR patients and to explore the role of climatic factors in the etiology of the disease. Material and Method: We retrospectively reviewed the patient files of PR cases that had been followed up in our clinic between 2000 and 2005. Demographic data of the patients as well as the date of applications were recorded. Temperature, raining, pressure and humidity data for the City of Bursa for years 2000-2005 were obtained from the General Directorate of Meteorology, Republic of Turkey. Any potential relationship between onset time of PR and meteorological parameters was investigated statistically by using cluster analysis. Results: We reviewed the medical records of 413 patients, of whom 271 were female and 142 were male. Herald plaque was seen in 88 patients (21.3%. Pityriasis rosea was observed predominantly in persons between 20 and 29 years of age (139 patients; 33.6%. Distribution of number of cases between 2000-2005 was 51, 57, 80, 75, 63, 87. The highest number of patients was seen in winter (n: 122; 29.5% followed by spring (n: 101; 24.4%, autumn (n: 101; 24.4% and summer (n: 89; 21.7%. No statistically significant difference was found between annual and seasonal changes in the incidence of PR (p>0.05.Conclusion: We conclude that although the relation between PR and seasonal factors was not statistically significant in our study, multi-centric studies on large series of patients are needed to further investigate this topic.

  10. Detection of Malassezia Species Isolated From Patients With Pityriasis Versicolor and Seborrheic Dermatitis Using Nested-PCR

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    Zarei Mahmoudabadi

    2014-12-01

    Full Text Available Background The species of the genus Malassezia are lipophilic and dimorphic yeasts that are regarded as part of the normal flora of the skin of humans and warm-blooded animals. These organisms are the cause of superficial mycosis in humans and other animals, and are common in pityriasis versicolor and seborrheic dermatitis. Objectives The purpose of this study was to determine the frequency of common Malassezia species in patients affected by pityriasis versicolor and seborrheic dermatitis using of the nested PCR method, in the city of Ahvaz. Patients and Methods In the present study, 85 samples from patients with pityriasis versicolor and seborrheic dermatitis were analyzed by the nested-PCR method. During the first stage, the internal transcribed spacer (ITS region from the ribosomal DNA was reproduced using primers ITS4-R and ITS1F-N. During the second stage, the product of the first step was used as DNA and using three special primer pairs, including Mf-F, 5.8SR and M.gl-F, 5.8SR and M.rt-F and M.rt-R, the inner part of the first phase was detected. Results The most common isolate was Malassezia furfur (51.3% followed by M. globosa (35.2% and M. restricta (13.5%. Amongst the 30 patients with seborrheic dermatitis, in 15 cases (65.2% M. restricta, in six cases (26.1% M. globosa and in two cases (8.7% M. furfur was detected and in seven patients no isolate was detected. Conclusions The nested-PCR is a rapid and repeatable method for identification of important Malassezia species and this method is recommended for use on more patients. In addition the most common agents of pityriasis versicolor and seborrheic dermatitis were M. furfur and M. restricta, respectively.

  11. The diagnostic criteria of pityriasis rosea and Gianotti-Crosti syndrome - a protocol to establish diagnostic criteria of skin diseases.

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    Chuh, A; Zawar, V; Sciallis, G F; Lee, A

    2015-01-01

    We established and validated diagnostic criteria for pityriasis rosea and Gianotti-Crosti syndrome. In this paper, we compare and contrast both diagnostic criteria to formulate a protocol in establishing diagnostic criteria for other dermatological diseases. The diagnostic criteria are similar in employing clear dividing lines and conjunctions ('and/or') to assure high reliability. Both sets of criteria should be applicable for all ethnic groups. Spontaneous remission is not included, so diagnosis is not delayed while waiting for disease remission. Laboratory investigations are not enlisted, so that the criteria can be used in medical care systems in different parts of the world. The diagnostic criteria are different in that pathognomonic clinical manifestations exist for pityriasis rosea, such as the herald patch and the orientation of lesions along the lines of skin cleavages. These features, however, score low for sensitivity. These specific manifestations are not seen in Gianotti-Crosti syndrome. Such differences led to different categorisation of clinical features. Atypical variants are more common for pityriasis rosea. The diagnostic criteria for pityriasis rosea therefore do not include a list of differential diagnoses, while diagnostic criteria for Gianotti-Crosti syndrome do. Using this comparison, we constructed a protocol to establish diagnostic criteria for other skin diseases. We advocate the need to justify the establishment of diagnostic criteria, that multiple diagnostic criteria for the same disease should be avoided, that diagnostic criteria should be compatible with the disease classification if applicable, and that the scope should be well-delineated with regard to clinical variants. We outline the need for validation studies to assess the criteria-related validity, test-retest intra-clinician reliability, and inter-clinician reliability. We emphasise that the establishment of diagnostic criteria should not be a generic process. We also

  12. Randomized comparative clinical trial of artemisia sieberi 5% lotion and clotrimazole 1% lotion for the treatment of pityriasis versicolor

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    Rad Farrokh

    2008-01-01

    Full Text Available Aims: To compare the therapeutic effects of topical Artremisia sieberi 5% lotion with topical clotrimazole 1% lotion in the treatment of pityriasis versicolor. Materials and Methods: 100 patients with pityriasis versicolor and microscopic identification of Malassezia furfur were randomly assigned to treatment with either topical Artemisia sieberi 5% lotion (group 1 or topical clotrimazole 1% lotion (group 2 for 2 weeks. Group 1 and group 2 consisted of 51 and 49 patients respectively. The patients were evaluated both clinically and mycologically at baseline and every 2 weeks for a period of 4 weeks. Results: At the end of the second week, clinical cure rates were 86.3% and 65.3% for group 1 and group 2 respectively ( P < 0.01, but at the same time mycological cure rate was 92.2% for group 1 and 73.5% for group 2 ( P < 0.05. At the end of the fourth week, clinical cure rates were 86.3% and 59.2% for group 1 and group 2 respectively ( P < 0.01, and at the same time mycologic cure rate was 96.1% for group 1 and 65.3% for group 2 ( P < 0.01. Conclusions: The results of this study demonstrated that Artemisia sieberi 5% lotion was more effective than clotrimazole 1% lotion in the treatment of pityriasis versicolor.

  13. Identification of Malassezia Species Isolated from Patients with Pityriasis Versicolor Using PCR-RFLP Method in Markazi Province, Central Iran.

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    Mojtaba Didehdar

    2014-05-01

    Full Text Available The lipophilic yeasts of Malassezia species are members of the normal skin microbial that are cause of pityriasis versicolor. Pityriasis versicolor is a common superficial fungal infection with world-wide distribution. The phenotypic methods for identification of Malassezia species usually are time consuming and unreliable to differentiate newly identified species. But DNA-based techniques rapidly and accurately identified Malassezia species. The purpose of this study was isolation and identification of Malassezia Species from patients with pityriasis versicolor by molecular methods in Markazi Province, Central Iran in 2012.Mycologic examinations including direct microscopy and culture were performed on clinical samples. DNA extraction was performed from colonies. The ITS1 region of rDNA from isolates of Malassezia species were amplified by PCR reaction. The PCR were digested by Cfo I enzyme.From 70 skin samples, were microscopically positive for Malassezia elements, 60 samples were grown on culture medium (85.7%. Using PCR-RFLP method, that was performed on 60 isolates, 37(61.6% M. globosa, 14(23.3% M. furfur, 5(8.4% M. sympodialis and 4(6.7% M. restrictawere identified. In one case was isolated M. globosa along with M. restricta.The PCR-RFLP method is a useful and reliable technique for identification of differentiation of Malas-sezia species.

  14. Identification of Malassezia species isolated from patients with seborrhoeic dermatitis, atopic dermatitis, pityriasis versicolor and normal subjects.

    Science.gov (United States)

    Nakabayashi, A; Sei, Y; Guillot, J

    2000-10-01

    We identified Malassezia species isolated from 42 patients with seborrhoeic dermatitis, 17 patients with atopic dermatitis, 22 patients with pityriasis versicolor, 35 normal subjects and 73 healthy medical students. Regarding the prevalence of Malassezia species in the 35 normal subjects, the frequency of isolation of Malassezia globosa was 22%, M. sympodialis 10% and M. furfur 3%. M. slooffiae, M. pachydermatis, M. restricta and M. obtusa were infrequently isolated from normal skin. Two different species were isolated coincidentally from seven samples. In the patients with atopic dermatitis, M. furfur was isolated more frequently from lesional skin (21%) than non-lesional skin (11%). However, there was no statistical significance. Therefore, this result, by itself, is insufficient to prove that M. furfur should be considered to be an exacerbating factor of atopic dermatitis. In seborrhoeic dermatitis, M. furfur (35%) and M. globosa (22%) were isolated from lesional skin on the face at significantly high rates in comparison with the normal subjects. Therefore, M. furfur and/or M. globosa may be pathogens of seborrhoeic dermatitis. M. globosa was isolated at a frequency of 55% from lesional skin of pityriasis versicolor, while all other species were below 10%. These data suggest that the pathogenic species of pityriasis versicolor is M. globosa.

  15. [Levels of selenium in urine after treatment of pityriasis versicolor with a 1.0% selenium sulfide].

    Science.gov (United States)

    Costa Martins, J E; Macedo De Souza, E; Salebian, A; Sampaio, S A

    1976-01-01

    The treatment of pityriasis versicolor by the topical application of selenium sulfide 1% was studied in two groups of patients. Diagnosis and response to therapy was determined by clinical observation. Wood's light fluorescence, and direct microscopic examination. The efficacy of three different therapeutic regimes was studied in one group by the application of the drug to the entire skin for either five minutes, fifteen minutes, or twelve hours for eighteen days. Each method proved equally effective in resolving the infection. Therefore, the cutaneous application of selenium sulfide 1 % for five minutes daily for eighteen days is the recommended treatment for pityriasis versicolor. The percutaneous absorption of selenium sulfide was also studied in another groups who applied the drug to the entire skin for five minutes for eighteen days. Fluorimetric analysis of urinary samples collected on the third and thirteenth days of treatment revealed no significant increase in the excretion of selenium as compared to pretreatment levels. Systemic toxicity was not observed in any of the patients treated. The results suggest that the selenium sulfide is absorbed poorly from the skin and is a safe and effective therapy for pityriasis versicolor.

  16. A reappraisal of the role of Pityrosporum orbiculare in pityriasis versicolor and the significance of extracellular lipase.

    Science.gov (United States)

    Catterall, M D; Ward, M E; Jacobs, P

    1978-12-01

    Pityrosporum orbiculare is an obligate lipophilic yeast in vitro, which suggests it possesses an extracellular lipase crucial for nutrition. If present in vivo, the enzyme would enable the yeast to utilize skin surface lipids, which may therfore play an important role in the pathogenesis of pityriasis versicolor. Cultured P. orbiculare and biopsy material from patients with pityriasis versicolor were investigated for the presence of lipase by electron microscope histochemistry. At sites of lipase activity, fatty acid hydrolyzed from Tween 80 substrate reacts with Ca++ ions to form an insoluble Ca++ soap. Exchange of Ca++ with Pb++ enables the sites of lipase activity to be visualized as electron dense deposits of insoluble lead soap. Surface lipase activity was apparent when the technique was applied to P. orbiculare grown on lipid containing medium and its specificity confirmed by removal of substrate and inhibition by di-isopropyl fluorophosphate and quinine hydrochloride, but not by sodium fluoride. When the same technique was applied to stratum corneum infected with Pityrosporum furfur (Malassez), no reaction product could be detected. It is postulated that lipase, although critical for fungal nutrition in vitro, is unlikely to be of importance in vivo. Skin surface lipids are therefore probably not relevant to the pathogenesis of pityriasis versicolor.

  17. Cytotoxic constituents of the bark of Plumeria rubra collected in Indonesia.

    Science.gov (United States)

    Kardono, L B; Tsauri, S; Padmawinata, K; Pezzuto, J M; Kinghorn, A D

    1990-01-01

    By bioactivity-directed fractionation, six cytotoxic constituents have been characterized from the bark of Plumeria rubra collected in Indonesia. Three iridoids, fulvoplumierin [1], allamcin [2], and allamandin [3], as well as 2,5-dimethoxy-p-benzoquinone [4], were found to be active constituents of the P. rubra petroleum-ether- and CHCl3-soluble extracts. Cytotoxic compounds isolated from the H2O-soluble extract of the bark were the iridoid plumericin [5], and the lignan liriodendrin [6]. Each of these substances was found to demonstrate general cytotoxic activity when evaluated with a panel of cell lines composed of murine lymphocytic leukemia (P-388) and a number of human cancer cell-types (breast, colon, fibrosarcoma, lung, melanoma, KB). Five additional iridoids, 15-demethylplumieride [7], plumieride [8], alpha-allamcidin [9], beta-allamcidin [10], and 13-O-trans-p-coumaroylplumieride [11], were obtained as inactive constituents. Compound 7 was found to be a novel natural product, and its structure was determined by spectroscopic methods and by conversion to plumieride [8]. The configuration of the C-4 stereocenter was unambiguously assigned for compounds 9 and 10, and certain nmr reassignments have been provided for compound 1.

  18. Structural Elucidation of two Compounds from the Fruit of Medicinally Important Plant, Basella Rubra

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    Swarnali Nath Choudhury

    2016-03-01

    Full Text Available Basella rubra is a medicinal plant species found in India and other parts of Asia and tropical Africa. It improves the appetite, useful in biliousness, leprosy, dysentery, ulcers and it has antiviral and antipyretic activity. The red pigment from the fruit has good colouring ability. It is bright purple at pH 3-7. It is a good additive and a safe, non-poisonous colorant. At present, the dyestuff industry has grown rapidly because of the vital role played by small – scale sector, which is responsible for the production of azo, acids, basics and direct dyes. But such synthetic dyes have toxic effect and hence may not be useful in edible substances. Therefore keeping this in mind the structure of two separated compounds from the fruit pigment of medicinally important plant Besella rubra were elucidated. The structures of the compounds have been characterized on the basis of spectral data such as IR, 1H NMR, 13C NMR and Mass spectral studies.

  19. Mineral Fertilization with UAN on Natural Grassland Festuca rubra L. with Agrostis capillaries L.

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    Ioan Rotar

    2016-11-01

    Full Text Available An important part of efficient livestock production is ensuring the sufficient grass for hay and pasture. However, low soil nutrient levels often limit forage production. With good fertilizer management and soil fertility, the productivity of many hay and pasture fields can be greatly improved. Through good fertilizer management, the productivity of many hay and pasture fields can be significantly improved by Ross H. McKenzie (2005. The aim of this paper was the effect of fertilization with liquid fertilizer (UAN the harvest of dry and floristic composition changing on natural grassland. The experiment whose results we present was placed in 2014 in the place in Baisoara Mountain village, Cluj County. Experience has been placed on the Festuca rubra and Agrostis capillaries - of grassland type. The natural grassland of Festuca rubra with Agrostis capillaries responded very well to mineral fertilizers with liquid fertilizer UAN. The floristic composition of natural grassland fertilized with liquid fertilizers based on nitrogen, it can be seen an increase the Gramineae families and an evidence downward trend from Fabaceae families.

  20. Morphology and molecular phylogeny of Paragorgia rubra sp. nov. (Cnidaria: Octocorallia), a new bubblegum coral species from a seamount in the tropical Western Pacific

    Science.gov (United States)

    Li, Yang; Zhan, Zifeng; Xu, Kuidong

    2017-07-01

    A new species of bubblegum coral, Paragorgia rubra sp. nov., discovered from a seamount at a water depth of 373 m near the Yap Trench is studied using morphological and molecular approaches. Paragorgia rubra sp. nov. is the fourth species of the genus found in the tropical Western Pacific. The new gorgonian is red-colored, uniplanar, and measures approximately 530 mm high and 440 mm wide, with autozooids distributed only on one side of the colony. Paragorgia rubra sp. nov. is most similar to P. kaupeka Sánchez, 2005, but differs distinctly in the polyp ovals with large and compound protuberances (vs. small and simple conical protuberances) and the medullar spindles possessing simple conical protuberances (vs. compound protuberances). Moreover, P. rubra sp. nov. differs from P. kaupeka in the smaller length/width ratio of surface radiates (1.53 vs. 1.75). The genetic distance of the mtMutS gene between P. rubra sp. nov. and P. kaupeka is 0.66%, while the intraspecific distances within Paragorgia Milne-Edwards & Haime, 1857 except the species P. regalis complex are no more than 0.5%, further supporting the establishment of the new species. Furthermore, the ITS2 secondary structure of P. rubra sp. nov. is also different from those of congeners. Phylogenetic analyses indicate Paragorgia rubra sp. nov. and P. kaupeka form a clade, which branched early within Paragorgia and diversified approximately 15 Mya.

  1. Genetic differentiation between the ant Myrmica rubra and its microgynous social parasite

    DEFF Research Database (Denmark)

    Vepsäläinen, K.; Ebsen, J. R.; Savolainen, R.;

    2009-01-01

    that the parasitic morph of M. rubra may be an incipient species, but it remains unclear to what extent the observed genetic differentiation between host and inquiline is due to possible assortative mating and selection against hybrids or to recurrent bottlenecking and genetic drift. We conclude that an explicitly...

  2. Root desiccation and drought stress responses of bareroot Quercus rubra seedlings treated with a hydrophilic polymer root dip

    Science.gov (United States)

    Kent G. Apostol; Douglass F. Jacobs; R. Kasten Dumroese

    2009-01-01

    Root hydrogel, a hydrophilic polymer, has been used to improve transplanting success of bareroot conifer seedlings through effects on water holding capacity. We examined mechanisms by which Terra-sorb Fine Hydrogel reduces damage that occurs when roots of 1-year old, dormant northern red oak (Quercus rubra L.) were subjected to shortterm (1, 3, and 5...

  3. Pityriasis Rosea

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    ... Boards study tools Online Learning Center Meetings and events Make a difference Career planning Media Relations Toolkit AAD apps Academy meeting Chronic urticaria—for members Chronic urticaria—for public Dermatology World Dialogues in Dermatology JAAD Mohs AUC ...

  4. Pityriasis Rosea

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    ... Genitals and Urinary Tract Glands & Growth Head Neck & Nervous System Heart Infections Learning Disabilities Obesity Orthopedic Prevention Sexually Transmitted Skin Tobacco Treatments Injuries & ...

  5. New pyrone and quinoline alkaloid from Almeidea rubra and their trypanocidal activity

    Energy Technology Data Exchange (ETDEWEB)

    Ambrozin, Alessandra R.P.; Mafezoli, Jair; Vieira, Paulo C.; Fernandes, Joao B.; Silva, M. Fatima das G.F. da [Sao Carlos Univ., SP (Brazil). Dept. de Quimica]. E-mail: paulo@dq.ufscar.br; Ellena, Javier A. [Sao Paulo Univ., Sao Carlos, SP (Brazil). Inst. de Fisica; Albuquerque, Sergio de [Sao Paulo Univ., Ribeirao Preto, SP (Brazil). Faculdade de Ciencias Farmaceuticas. Dept. de Analises Clinicas, Toxicologicas, Bromatologicas

    2005-05-15

    The investigation of the ethyl acetate fraction of methanol extract from leaves of Almeidea rubra A. St.-Hil. (Rutaceae) afforded two new compounds 4-methoxy-6-[2-(methylamino)phenyl]-2Hpyran- 2-one and rel-(7R,8R)-8-[(E)-3-hydroxy-3-methyl-1-butenyl]-4,8-dimethoxy-5,6,7,8- tetrahydrofuro[2,3-b]quinoline-7-yl acetate, along with the known compounds arborinine, N-methyl- 1-hydroxy-3-methoxyacridone, skimmianine, kokusagine, isodutaduprine, isoskimmianine, and isokokusagine. Their structures were established based on their spectral data, and for the new compounds these data are described herein. Additionally, these compounds were assayed on the tripomastigote forms of Trypanosoma cruzi showing moderate trypanocidal activity. (author)

  6. Population structure of Haliotis rubra from South Australia inferred from nuclear and mtDNA analyses

    Institute of Scientific and Technical Information of China (English)

    LI Zhongbao; Sharon A Appleyard; Nicholas G Elliott

    2006-01-01

    Microsatellite loci and mtDNA-RFLPs were surveyed in four spatially separated populations of Haliotis rubra and two populations of putative Haliotis conicorpora from South Australia. A high level of microsatellite genetic diversity was observed in all populations although several loci were characterized by homozygote excesses, probably due to null alleles. MtDNA variation was also moderate with an average of 80% haplotype variation across the six populations. Despite the high levels of genetic variation, significant pair-wise spatial differentiation is not detected among the populations. Hierarchical AMOVA analysis revealed very low levels of genetic partitioning on either a spatial or putative species level. Both molecular techniques revealed little genetic differentiation across the six populations, suggesting a panmictic population model for these South Australian abalone populations. Furthermore, no molecular evidence suggests that the putative H. conicorpora individuals sampled from South Australia belong to a separate species.

  7. Preliminary research on methane oxidizing bacteria. [Methylococcus capsulatus, M. luteus, M. minimus, M. chroococous, Methylomonas rubra

    Energy Technology Data Exchange (ETDEWEB)

    Godlewska-Lipa, W.; Mrozowska, J.

    1983-01-01

    Laboratory research is discussed on use of bacteria for methane control in underground coal mines. Coal samples from a dozen black coal mines in Upper and Lower Silesia were used in experiments. A mixture of methylotrophic bacteria which used methane as the only source of carbon and energy was obtained. The following types of bacteria dominated in the culture: Methylococcus capsulatus, Methylococcus luteus, Methylococcus minimus, Methylococcus chroococcus and Methylomonas rubra. The optimum conditions for culture growth were determined: use of methane mixture with air, proportion 4 to 1, use of natural medium enriched with nitrogen and phosphorus compounds or the Whittenbury medium, temperature of 30 C, pH value from 6.2 to 8.0. Excessive salt content in mine water negatively influenced culture growth: concentration of ions of SO/sub 4/ did not exceed 400 mg/dcm/sup 3/, and of chlorine 250 mg/dcm/sup 3/. 28 references.

  8. Fungal endophyte (Epichloe festucae alters the nutrient content of Festuca rubra regardless of water availability.

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    Beatriz R Vázquez-de-Aldana

    Full Text Available Festuca rubra plants maintain associations with the vertically transmitted fungal endophyte Epichloë festucae. A high prevalence of infected host plants in semiarid grasslands suggests that this association could be mutualistic. We investigated if the Epichloë-endophyte affects the growth and nutrient content of F. rubra plants subjected to drought. Endophyte-infected (E+ and non-infected (E- plants of two half-sib lines (PEN and RAB were subjected to three water availability treatments. Shoot and root biomass, nutrient content, proline, phenolic compounds and fungal alkaloids were measured after the treatments. The effect of the endophyte on shoot and root biomass and dead leaves depended on the plant line. In the PEN line, E+ plants had a greater S:R ratio than E-, but the opposite occurred in RAB. In both plant lines and all water treatments, endophyte-infected plants had greater concentrations of N, P and Zn in shoots and Ca, Mg and Zn in roots than E- plants. On average, E+ plants contained in their shoots more P (62%, Zn (58% and N (19% than E- plants. While the proline in shoots increased in response to water stress, the endophyte did not affect this response. A multivariate analysis showed that endophyte status and plant line impose stronger differences in the performance of the plants than the water stress treatments. Furthermore, differences between PEN and RAB lines seemed to be greater in E- than in E+ plants, suggesting that E+ plants of both lines are more similar than those of their non-infected version. This is probably due to the endophyte producing a similar effect in both plant lines, such as the increase in N, P and Zn in shoots. The remarkable effect of the endophyte in the nutrient balance of the plants could help to explain the high prevalence of infected plants in natural grasslands.

  9. Geographic Variation in Festuca rubra L. Ploidy Levels and Systemic Fungal Endophyte Frequencies

    Science.gov (United States)

    Dirihan, Serdar; Helander, Marjo; Väre, Henry; Gundel, Pedro E.; Garibaldi, Lucas A.; Irisarri, J. Gonzalo N.; Saloniemi, Irma; Saikkonen, Kari

    2016-01-01

    Polyploidy and symbiotic Epichloë fungal endophytes are common and heritable characteristics that can facilitate environmental range expansion in grasses. Here we examined geographic patterns of polyploidy and the frequency of fungal endophyte colonized plants in 29 Festuca rubra L. populations from eight geographic sites across latitudes from Spain to northernmost Finland and Greenland. Ploidy seemed to be positively and negatively correlated with latitude and productivity, respectively. However, the correlations were nonlinear; 84% of the plants were hexaploids (2n = 6x = 42), and the positive correlation between ploidy level and latitude is the result of only four populations skewing the data. In the southernmost end of the gradient 86% of the plants were tetraploids (2n = 4x = 28), whereas in the northernmost end of the gradient one population had only octoploid plants (2n = 8x = 56). Endophytes were detected in 22 out of the 29 populations. Endophyte frequencies varied among geographic sites, and populations and habitats within geographic sites irrespective of ploidy, latitude or productivity. The highest overall endophyte frequencies were found in the southernmost end of the gradient, Spain, where 69% of plants harbored endophytes. In northern Finland, endophytes were detected in 30% of grasses but endophyte frequencies varied among populations from 0% to 75%, being higher in meadows compared to riverbanks. The endophytes were detected in 36%, 30% and 27% of the plants in Faroe Islands, Iceland and Switzerland, respectively. Practically all examined plants collected from southern Finland and Greenland were endophyte-free, whereas in other geographic sites endophyte frequencies were highly variable among populations. Common to all populations with high endophyte frequencies is heavy vertebrate grazing. We propose that the detected endophyte frequencies and ploidy levels mirror past distribution history of F. rubra after the last glaciation period, and local

  10. Papulopustular rosacea, skin immunity and Demodex: pityriasis folliculorum as a missing link.

    Science.gov (United States)

    Forton, F M N

    2012-01-01

    Papulopustular rosacea (PPR) is a common facial skin disease, characterized by erythema, telangiectasia, papules and pustules. Its physiopathology is still being discussed, but recently several molecular features of its inflammatory process have been identified: an overproduction of Toll-Like receptors 2, of a serine protease, and of abnormal forms of cathelicidin. The two factors which stimulate the Toll-like receptors to induce cathelicidin expression are skin infection and cutaneous barrier disruption: these two conditions are, at least theoretically, fulfilled by Demodex, which is present in high density in PPR and creates epithelial breaches by eating cells. So, the major pathogenic mechanisms of Demodex and its role in PPR are reviewed here in the context of these recent discoveries. In this review, the inflammatory process of PPR appears to be a consequence of the proliferation of Demodex, and strongly supports the hypothesis that: (1) in the first stage a specific (innate or acquired) immune defect against Demodex allows the proliferation of the mite; (2) in the second stage, probably when some mites penetrate into the dermis, the immune system is suddenly stimulated and gives rise to an exaggerated immune response against the Demodex, resulting in the papules and the pustules of the rosacea. In this context, it would be very interesting to study the immune molecular features of this first stage, named "pityriasis folliculorum", where the Demodex proliferate profusely with no, or a low immune reaction from the host: this entity appears to be a missing link in the understanding of rosacea.

  11. Is narrowband ultraviolet B monotherapy effective in the treatment of pityriasis lichenoides?

    Science.gov (United States)

    Park, Jung-Min; Jwa, Seung-Wook; Song, Margaret; Kim, Hoon-Soo; Chin, Hyun-Woo; Ko, Hyun-Chang; Kim, Moon-Bum; Kim, Byung-Soo

    2013-08-01

    Pityriasis lichenoides (PL) is a self-limiting papulosquamous disease that may persist for years and is associated with a high relapse rate. To date, few comparative studies have investigated the efficacy of narrowband ultraviolet B (NB-UVB) phototherapy and other therapies in the treatment of PL. The present study retrospectively compared the clinical efficacies of NB-UVB phototherapy, systemic therapy, and a combination of NB-UVB and systemic medication in the treatment of PL. Seventy patients diagnosed with PL were enrolled in this study. They were divided into three subgroups: the NB-UVB treatment group; the systemic treatment group; and the combination treatment group. Therapeutic efficacy was evaluated according to whether the subjects demonstrated a complete response (> 90% improvement in skin lesions), partial response (50-90% improvement), or no response (< 50% improvement) to treatment. A 91.9% complete response rate was achieved in the NB-UVB group, whereas only 69.2 and 80.0% of patients achieved a complete response in the systemic and combination treatment groups, respectively; these differences were not statistically significant. The mean treatment periods were 8.3, 5.3, and 7.9 weeks in the NB-UVB, systemic, and combination treatment groups, respectively; these differences were also not significant. Monotherapy using NB-UVB is effective in achieving a complete response in the treatment of PL and thus eliminates the need for concurrent systemic medication. © 2013 The International Society of Dermatology.

  12. Higher Expression of Toll-like Receptors 3, 7, 8, and 9 in Pityriasis Rosea

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    Mostafa Abou El-Ela

    2017-03-01

    Full Text Available Background Pityriasis rosea (PR is a common papulosquamous skin disease in which an infective agent may be implicated. Toll-like receptors (TLRs play an important role in immune responses and in the pathophysiology of inflammatory skin diseases. Our aim was to determine the possible roles of TLRs 3, 7, 8, and 9 in the pathogenesis of PR. Methods Twenty-four PR patients and 24 healthy individuals (as controls were included in this case control study. All recruits were subjected to routine laboratory investigations. Biopsies were obtained from one active PR lesion and from healthy skin of controls for the detection of TLR 3, 7, 8, and 9 gene expression using real-time polymerase chain reaction. Results This study included 24 patients (8 females and 16 males with active PR lesions, with a mean age of 28.62 years. Twenty four healthy age- and sex-matched individuals were included as controls (8 females and 16 males, with a mean age of 30.83 years. The results of the routine laboratory tests revealed no significant differences between both groups. Significantly elevated expression of all studied TLRs were detected in PR patients relative to healthy controls (p < .001. Conclusions TLRs 3, 7, 8, and 9 might be involved in the pathogenesis of PR.

  13. The spectrum of Malassezia species isolated from students with pityriasis vesicolor in Nigeria.

    Science.gov (United States)

    Ibekwe, P U; Ogunbiyi, A O; Besch, R; Ruzicka, T; Sárdy, M

    2015-04-01

    Pityriasis versicolor (PV) is a common superficial fungal infection of the skin caused by Malassezia. Initially M. furfur was suggested as its main aetiological agent; however, more recent studies suggest M. globosa as the dominant species. The possibility of a variance in predominant species based on geographical basis has not been fully evaluated. The objective of this study was to identify the Malassezia species on affected and non-affected skin of students with PV who reside in a tropical environment (Abuja, Nigeria) and correlate them to clinical characteristics. In this study, the literature on prevalence of Malassezia genus in PV was also reviewed. Samples were taken from 304 PV lesions and 110 normal appearing skin. Microscopy, culture and identification of Malassezia species utilising polymerase chain reaction-restriction fragment length polymorphism analysis were performed. Three Malassezia species were detected in PV with the major species being M. furfur. On normal appearing skin, M. furfur (77.6%) and M. restricta (10.4%) were both detected. No case of M. globosa was identified in this study. There was no significant difference between species identified and clinical features of PV. M. furfur is probably still the most predominant species causing PV in the tropical environment. © 2015 Blackwell Verlag GmbH.

  14. Human Herpes Virus-6 and Human Herpes Virus -7 in Pityriasis Rosea

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    Kıymet Baz

    2013-09-01

    Full Text Available Objective: The etiology of pityriasis rosea (PR remains unknown despite numerous investigations. In recent years, human herpes virus-6 (HHV-6 and HHV-7 were accused as causative agents in PR. The aim of this study was to evaluate the possible role of HHV-6 and HHV-7 in the pathogenesis of PR. Methods: Twenty three PR patients and 23 healthy blood donors as a control group were included in the study. Polymerase chain reaction (PCR with specific primers for HHV-6 and HHV-7 DNA sequences was performed on the serum samples of 23 active PR patients and controls, and also the lesional skin biopsies from 11 PR patients. Additionally, serum levels of IgM antibodies againts HHV-7 were detected by using indirect immunofluorescence test on the serum samples of all of the study population. Results: No statistically significant differences were detected between PR patients and controls regarding all serum results. Conclusion: These findings do not support a primary etiological role for HHV-6 and HHV-7 in PR as in some previous studies.

  15. Pityriasis Lichenoides et Varioliformis Acuta Due to Infection: A Case Report

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    Sibel Tekin

    2009-12-01

    Full Text Available A nine-year old girl admitted to our clinic with two months history of itchy skin eruption, initially started on the arms and then disseminated to all the body including the face. Dermatological examination revealed extensive papulosquamous lesions covered with hemorrhagic crust and central necrosis. Clinically the diagnosis was thought to be pityriasis lichenoides et varioliformis acuta (PLEVA and a skin biopsy was performed from a lesion which revealed exocytosis and spongiosis in epidermis, edema and exocytosis of erythrocytes in papillary dermis, perivascular lymphocytic infiltration in dermis. In laboratory evaluation, oropharyngeal culture was positive for Streptococcus pyogenes. The analysis of urine sample revealed leucocyturia and Escherichia coli grew on urine culture. Therapy with erythromycin, which was found to be sensitive against both pathogens, and also the main therapeutic agent for PLEVA started 250mg tb 4x1 orally, since the histopathological findings were also compatible with PLEVA. A rapid response was achieved and more than half of the lesions were found to be regressed in ten days. In this report, a child of PLEVA with a rapid and dramatic response to erythromycin therapy is described with a brief literature review.

  16. Higher Expression of Toll-like Receptors 3, 7, 8, and 9 in Pityriasis Rosea

    Science.gov (United States)

    El-Ela, Mostafa Abou; El-Komy, Mohamed; Hay, Rania Abdel; Hegazy, Rehab; Sharobim, Amin; Rashed, Laila; Amr, Khalda

    2017-01-01

    Background Pityriasis rosea (PR) is a common papulosquamous skin disease in which an infective agent may be implicated. Toll-like receptors (TLRs) play an important role in immune responses and in the pathophysiology of inflammatory skin diseases. Our aim was to determine the possible roles of TLRs 3, 7, 8, and 9 in the pathogenesis of PR. Methods Twenty-four PR patients and 24 healthy individuals (as controls) were included in this case control study. All recruits were subjected to routine laboratory investigations. Biopsies were obtained from one active PR lesion and from healthy skin of controls for the detection of TLR 3, 7, 8, and 9 gene expression using real-time polymerase chain reaction. Results This study included 24 patients (8 females and 16 males) with active PR lesions, with a mean age of 28.62 years. Twenty four healthy age- and sex-matched individuals were included as controls (8 females and 16 males, with a mean age of 30.83 years). The results of the routine laboratory tests revealed no significant differences between both groups. Significantly elevated expression of all studied TLRs were detected in PR patients relative to healthy controls (p < .001). Conclusions TLRs 3, 7, 8, and 9 might be involved in the pathogenesis of PR. PMID:28192646

  17. Efficacy of 308-nm xenon chloride excimer laser in pityriasis alba.

    Science.gov (United States)

    Al-Mutairi, Nawaf; Hadad, Ahmed Al

    2012-04-01

    Pityriasis alba (PA) is the most common cause of facial hypopigmentation presenting to the dermatologist. The objective of the current study was to study the effect of the 308-nm excimer laser in the treatment of PA. Twelve patients with 37 PA patches were enrolled in this study. The lesions were treated using the 308-nm excimer laser twice a week for 12 weeks. The hypopigmented areas were evaluated at baseline and at weeks 0, 3, 6, and 12 for scaling, hypopigmentation, and pruritus on a 4-point scale (0 = none to 3 = severe). All adverse effects were recorded. There were seven male and five female participants in (aged 5-21 years), with skin type III to V. After 1 month of laser therapy, the clinical scores were significantly lower than at baseline. Similar decreases were observed for the scaling and pruritus scores. Uneven skin color improved by the third week, and near-complete resolution was noticed by the end of 3 months. No serious or unpleasant side-effects were observed, and all patients completed the 12-week treatment. Patients were satisfied or very satisfied with the treatment. The 308-nm excimer laser is an effective therapeutic option for PA. © 2011 by the American Society for Dermatologic Surgery, Inc. Published by Wiley Periodicals, Inc.

  18. Atypical pityriasis rosea: a case report and a review of literature

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    Iqbal A. Bukhari

    2015-02-01

    Full Text Available Aim: Pityriasis rosea (PR is a common acute inflammatory skin disease characterized by pruritic erythematous papulosquamous eruption that is self-limited which can rarely pose a diagnostic challenge. In this report, we present a rare presentation of PR.Method: the case was completely evaluated including laboratory works and a final diagnosis of erythema multiforme-like PR was reached. Besides, we reviewed all atypical presentations of PR that are reported in the medical literature.Results: our patient has a morphological variant of PR which is erythema multiforme-like. The presence of a herald patch and  the rapid resolution of the symptoms supports our diagnosis. This variant is considered rare and to our knowledge, this is the seventh case of erythema multiforme-like PR reported in the medical literature.In conclusion: we report a case of erythema multiforme-like PR. It is important that physicians recognize the wide spectrum of PR variants so that appropriate management can be arranged. 

  19. Pityriasis versicolor during anti-TNF-α monoclonal antibody therapy: therapeutic considerations.

    Science.gov (United States)

    Balestri, Riccardo; Rech, Giulia; Piraccini, Bianca Maria; Antonucci, Angela; Ismaili, Alma; Patrizi, Annalisa; Bardazzi, Federico

    2012-09-01

    Anecdotal reports have shown that tumour necrosis factor (TNF)-α inhibition may cause unchecked superficial infection with the microorganisms responsible for pityriasis versicolor (PV). We observed several cases of PV, which is frequently resistant to topical therapies, in psoriatic patients undergoing anti-TNF-α monoclonal antibody therapy. To evaluate the incidence and the therapeutic management of PV in this group of individuals, between 1 January and 27 December 2010, we examined 153 psoriatic patients for the hypopigmented/hyperpigmented macular and scaling lesions associated with PV. All patients positive for PV were given topical therapy with miconazole nitrate cream twice daily for 28 days, after which they were re-evaluated. In patients non-responsive to topical therapy, we started systemic therapy with fluconazole, 300 mg week(-1) for 3 weeks. We diagnosed seven cases of PV. At the end of topical treatment, complete healing of lesions was observed in only one patient. In the other six patients, systemic treatment led to complete resolution of the infection. Although the onset of PV during anti-TNF-α therapy is seldom reported, it is not likely to be rare, but rather under-reported because of its limited pathological significance. In our opinion, the therapeutic management of this condition deserves greater consideration, as the use of topical treatments alone is largely ineffective compared with systemic treatment.

  20. [Ultrastructure of parapsoriasis lesions. Parapsoriasis en plaques and parakeratosis variegata as prelymphoma; differences from pityriasis lichenoides].

    Science.gov (United States)

    Orfanos, C E; Tsambaos, D

    1982-08-15

    The morphological alterations of involved skin in three different types of parapsoriasis were investigated in 9 patients by electron microscopy. Pityriasis lichenoides chronica (PLC) is characterized by a lymphohistiocytic dermal infiltrate and by epidermotropic histiocytic cells, which penetrate up to the horny layer. In parapsoriasis en plaques (PeP) and in parakeratosis variegata (PV) the dermal infiltrate is mainly composed of lymphocytoid cells, some of which, particularly in PV, reveal the features of Sézary-Cells (11% and 30% respectively). The epidermis is predominantly invaded by partly atypical lymphoid cells. In some instances membrane contacts between Langerhans cells, keratinocytes and atypical lymphoid cells can be observed. The increased number of epidermotropic cells and the increase of atypical lymphoid cells in the dermal infiltrate are the main ultrastructural features of the malignant transformation of PV. Finally, an important difference between PLC and the other two types of parapsoriasis is the fact that in PLC epidermotropic cells are mostly of histiocytic origin, whereas in PeP and PV they are mainly lymphocytes. The electron microscopic findings support the opinion that PLC should not be considered as a type of parapsoriasis and that PeP and PV probably correspond to prelymphoma.

  1. Pityriasis rosea: a natural history of pediatric cases in theCentral Anatolia Region of Turkey.

    Science.gov (United States)

    Çölgeçen, Emine; Kader, Çiğdem; Ulaş, Yılmaz; Öztürk, Pınar; Küçük, Öznur; Balcı, Mehmet

    2016-12-20

    This study aimed to evaluate the demographic, clinical, and epidemiological features of pityriasis rosea (PR) in a cohort of 46 children in Yozgat, a city in the Central Anatolia Region of Turkey. Forty-six children with PR were monitored at regular intervals (1, 2, 4, and 12 weeks) for 3 months from the time of diagnosis. A complete evaluation of the patient was performed at each visit. The average age of patients at time of diagnosis was 12 ± 3.9 years. Cases were most common in the winter (rainy, snowy months; n = 14, 31%). Fifteen patients had a medical history significant for the presence of upper respiratory tract infection, while skin PR manifestations were preceded by drug intake in a second group of 15 patients. The presence of a herald patch was observed in 78.3% of patients, most frequently on the trunk (n = 23). Pruritus occurred in 75% of patients. Median PR duration was 3 weeks (range: 1-20 weeks). The course of PR is similar in Turkish children and adults. The high prevalence of pruritus in children with PR in Turkey was also significant. Further evaluation of this finding comparing adults and children is now required.

  2. Pityriasis Lichenoides-like Mycosis Fungoides: Clinical and Histologic Features and Response to Phototherapy

    Science.gov (United States)

    Jang, Min Soo; Kang, Dong Young; Park, Jong Bin; Kim, Joon Hee; Park, Kwi Ae; Rim, Hark

    2016-01-01

    Background Pityriasis lichenoides (PL)-like skin lesions rarely appear as a specific manifestation of mycosis fungoides (MF). Objective We investigated the clinicopathological features, immunophenotypes, and treatments of PL-like MF. Methods This study included 15 patients with PL-like lesions selected from a population of 316 patients diagnosed with MF at one institution. Results The patients were between 4 and 59 years of age. Four patients were older than 20 years of age. All of the patients had early-stage MF. In all patients, the atypical lymphocytic infiltrate had a perivascular distribution with epidermotropism. The CD4/CD8 ratio was <1 in 12 patients. Thirteen patients were treated with either narrowband ultraviolet B (NBUVB) or psoralen+ultraviolet A (PUVA), and all of them had complete responses. Conclusion PL-like MF appears to have a favorable prognosis and occurrence of this variant in adults is uncommon. MF should be suspected in the case of a PL-like skin eruption. Therefore, biopsy is required to confirm the diagnosis of PL-like MF, and NBUVB is a clinically effective treatment. PMID:27746631

  3. Anesthetic Considerations for Neuraxial Anesthesia in Pregnant Patients With Pityriasis Rosea With Skin Lesions Covering the Lumbar Spine.

    Science.gov (United States)

    Werntz, Megan; Chun, Carlene; Togioka, Brandon Michael

    2016-10-15

    Pityriasis rosea (PR) is an acute exanthematous skin disease that is likely due to reactivation of human herpesviruses (HHVs) 6b and 7. In contrast to herpes simplex and zoster (alphaherpesviruses), HHV-6b and -7 (betaherpesviruses) are not found predominantly in skin lesions. This difference in virion location may decrease the possibility of causing central nervous system infection through skin contamination, but the risk for hematogenous spread likely remains the same. This article uses the first-known epidural placement through active PR to illustrate risk-benefit considerations when deciding between neuraxial and general anesthesia for obstetric patients with PR.

  4. A double-blind comparison of 2% ketoconazole and 1% clotrimazole in the treatment of pityriasis versicolor

    Directory of Open Access Journals (Sweden)

    Balwada R

    1996-01-01

    Full Text Available Forty adult patients of pityriasis versicolor were treated with either topical 2% ketoconazole cream (20 patients or topical 1% clotrimazole cream (20 patients. In global assessment of treatment after 2 weeks, 18 (90% out of 20 patients treated with ketoconazole cream were cured while 2 cases had considerable residual lesions. In clotrimazole treated group, 17 (85% out of 20 patients were cured and 3 still had considerable lesions. No significant difference was observed in response rates in the two groups. No side effects were reported in either groups.

  5. Histopathological spectrum of Psoriasiform dermatitis

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    PL Jayalakshmy

    2016-09-01

    Full Text Available Background: Psoriasiform dermatitis is a frequently encountered terminology in a wide variety of inflammatory dermatoses. It often poses challenges to both dermatologists and pathologists alike. Clinical features when considered alone may not be reliable, as they vary with both disease duration and treatment. On the contrary, histopathological material constitutes definite hard evidence, which can be preserved and will continue to be available for future review. The objective of the study is to study the histopathological findings in Psoriasiform dermatitis.Materials and Methods: This is a retrospective study in a tertiary care centre in Kerala, South India. All cases diagnosed as Psoriasis or mentioned as one of the differential diagnosis were included. The material included 66 skin biopsies. Patients with a previous diagnosis of the same were excluded from the study.Results: The lesions comprised 9% of the total number of skin biopsies. The age distribution pattern revealed that the highest percentage was in the 41-60 year age group (50% with a male preponderance of 65%. Psoriasis was the most common lesion (60.60% and Lichen simplex chronicus was the second most common lesion (10.60 %, encountered in the study.Conclusion: Some of the histopathological features are specific and characteristic for each entity like Psoriasis, Pityriasis rubra pilaris, Pityriasis rosea and Inflammatory linear verrucous epidermal nevus whereas some overlap in lesions like Prurigo nodularis, Lichen simplex chronicus and Allergic contact dermatitis. Hence, combination of proper clinical observation and histopathological study will give a conclusive diagnosis.

  6. Successful treatment of pityriasis lichenoides chronica with narrow-band ultraviolet B therapy in a patient with Keratitis-Ichthyosis-Deafness syndrome: a case report.

    Science.gov (United States)

    Salman, Andac; Gencosmanoglu, Dilek Seckin; Yucelten, Ayse Deniz; Elcioglu, Nursel; Richard, Gabriele; Demirkesen, Cuyan

    2016-05-15

    Keratitis-ichthyosis-deafness (KID) syndrome is a rare genodermatosis causing ichthyosis-like skin lesions, keratitis, and deafness. Herein, we report a patient with this rare syndrome in association with pityriasis lichenoides chronica, which was succesfully treated with narrow-band ultraviolet B phototherapy despite our concerns regarding the increased risk of squamous cell carcinoma, hyperpyrexia, and keratitis.

  7. Epidemiological Characters of Pityriasis Versicolor and Erythrasma among Admitted Patients of Medical Mycology Lab of Kermanshah University of Medical Sciences 1994 -2011

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    Mikaeili, A. (PhD

    2014-05-01

    Full Text Available Background and Objective: The rate of superficial mycoses are increasing in special conditions. This retrospective study was conducted to determine the epidemiological parameters of Pityriasis versicolor and Erythrasma during 1994- 2011. Material and Methods: In this study, we assessed the results of direct microscopic study and the other data of the patients for Pityriasis versicolor and Erythrasma in 1994-2011. Results: Of 2265, 1294 (57% suffered from pityriasis versicolor, who were mostly males (60%. The highest frequency was related to 20-29 year old and the lowest to 0-9. High school and university students were the most infected groups (33%, September was the most common period and the most common site of involvement was chest and abdomen. The people infected with Erythrasma (971; 42%, were mostly 30 -39 year old , males( 58% , urban ( 98% , reported in July and involved in groin. Conclusion: The frequency of both diseases was high in active age group, males, and the hot months of the year, which are the most common predisposing factors. Keywords: Pityriasis Versicolor; Erythrasma; Kermanshah

  8. Basella alba rubra spinach pigment-sensitized TiO2 thin film-based solar cells

    Science.gov (United States)

    Gokilamani, N.; Muthukumarasamy, N.; Thambidurai, M.; Ranjitha, A.; Velauthapillai, Dhayalan

    2015-03-01

    Nanocrystalline TiO2 thin films have been prepared by sol-gel dip coating method. The X-ray diffraction results showed that TiO2 thin films annealed at 400, 450 and 500 °C are of anatase phase and the peak corresponding to the (101) plane is present in all the samples. The grain size of TiO2 thin films was found to increase with increasing annealing temperature. The grain size is found to be 20, 25 and 33 nm for the films annealed at 400, 450 and 500 °C. The structure of the TiO2 nanocrystalline thin films have been examined by high-resolution transmission electron microscope, Raman spectroscopy and FTIR spectroscopy. TiO2 thin films were sensitized by natural dyes extracted from basella alba rubra spinach. It was found that the absorption peak of basella alba rubra extract is at about 665 nm. The dye-sensitized TiO2-based solar cell sensitized using basella alba rubra exhibited a J sc of 4.35 mA cm-2, V oc of 0.48 V, FF of 0.35 and efficiency of 0.70 %. Natural dyes as sensitizers for dye-sensitized solar cells are promising because of their environmental friendliness, low-cost production and fully biodegradable.

  9. The Impact of Nitrogen Fertilisation on the Evolution of Floristic Composition in Mixtures of Festuca rubra L.

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    Corina Cristea

    2012-05-01

    Full Text Available Festuca rubra L. is a good competitive species that makes up the floristic structure of temporary meadows and that are used for grazing or mixed use (haymaking field – grassland together with Festuca pratensis L., Phleum pratense L., Poa pratense L., Trifolium repens L. and Lotus corniculatus L. The paper aims at pointing out the evolution of the floristic composition of the vegetal cover in different mixtures based on (creeping red fescue (Festuca rubra L., Dutch / white clover (Trifolium repens L. and bird’s-foot trefoil (Lotus corniculatus L.. Analysis of mean results concerning the structure of the floristic composition of mixtures based on Festuca rubra L. (60% shows that in all 9 types of mixtures there was balance between the degree of participation of (creeping red fescue and the share of the other two legume species studied. In the control variants, in the two simple mixtures, the share of Dutch / white clover was 48% and that of bird’s-foot trefoil was 44%. These values decreased, on the average, with 10% when applying a rate of N50 and with 14% when applying a rate of N100. In the complex mixture, there was a mean value of the degree of participation of the two species of legumes of 46% (with a higher share of the bird’s-foot trefoil in the control variant, of 34% in the variant treated with N50 and of 30% in the variant treated with N100.

  10. THE EFFECT OF 30% RUBRA VARIETY OF ALPINIA GALANGA RHIZOME EXTRACT CREAM AS A TREATMENT TO ORAL CANDIDOSIS

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    Dyah Juniar Hynawatty

    2015-06-01

    Full Text Available The rubra variety of Alpinia galanga rhizome extract were compatible to the fibroblast tissue, non toxic, and potent in inhibiting Candida albicans growth. The purpose of this study was to find out the effect of the rubra variety of Alpinia galangal rhizome extract as a treatment to oral candidosis. The patients involved in this study were 20 diabetic patients, men and women. There were sixteen patients showed white patches of flecks on the tongue surface. After clinical examination, a direct smear was made and there were mass of candida hyphae on Periodoc Acid Schiff staining. For patient comfort, the extract of Alpinia galangal 30% was prepared as a cream in a tube. The cream was used topically on the flack, 4-5 times daily for 14 days. In case of the flecks persisted, the treatment was continued to 21 days. Mc Nemar test showed a significant difference between the group before and after treatment (p<0,05. It was concluded that 30% rubra variety of Alpinia galanga rhizome extract could be used as an alternative treatment for oral candidosis.

  11. CLINICAL EVALUATION OF EFFICACY OF SERTACONAZOLE 2% CREAM IN TREATMENT OF PITYRIASIS VERSICOLOR AND A COMPARISION WITH THAT OF CLOTRIMAZOLE 1% CREAM

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    Lakshmi Tatavarthi

    2015-04-01

    Full Text Available BACKGROUND: Pityriasis versicolor is a mild superficial, chronic recurrent fungal infection. Many topical agents have been used with varying degree of success and high recurrence rate. The current study was conducted to clinically evaluate the efficacy of sertaconazole 2% in treating and preventing recurrences of pityriasis versicolor as compared to clotrimazole1%cream. AIMS: Clinical evaluation of the efficacy of sertaconazole 2% cream in the treatment of pityriasis versicolor and its comparison with that of clotrimazole 1% cream. MATERIALS & METHODS: 110 patients who were diagnosed clinically and microscopically as pityriasis versicolor and fulfilling the criteria were enrolled, of which 55 were treated with 2% sertaconazole cream and 55 with 1% clotrimazole cream twice daily for 4 weeks. At the end of fourth week patients were examined both clinically and mycologically. Follow up was done at 6 weeks to note any relapse clinically and mycologically. RESULTS : Out of 110 patients 4 patients using sertaconazole, 6 patients using clotri mazole were lost for follow - up and excluded from the study. Global assessment was done at the end of treatment i.e., 4 weeks with clinical and mycological cure rate, revealed that 42(82.3% of the sertaconazole group, 30(61.2% of the clotrimazole group we re improved clinically. Mycological examination at the same time was negative in 44(86.3%, 33(67.4% respectively. 7(13.7% of sertaconazole group, 12(24.48% of clotrimazole group show no significant change. 4(8.16% patients using clotrimazole complaine d of deterioration of symptoms but none using sertaconazole. CONCLUSION : Comparing the results obtained in this trial showed that sertaconazole was more efficacious than clotrimazole in the treatment of pityriasis versicolor because of its direct membrane damaging effect. But in terms of pigmentary resolution sertaconazole is not comparable to clotrimazole cream due to persistent effect of azelic acid.

  12. Single-dose oral fluconazole versus topical clotrimazole in patients with pityriasis versicolor: A double-blind randomized controlled trial.

    Science.gov (United States)

    Dehghan, Mohammad; Akbari, Negin; Alborzi, Nazila; Sadani, Somayeh; Keshtkar, Abas A

    2010-08-01

    This study was designed to compare the therapeutic effects of topical clotrimazole and systemic fluconazole in pityriasis versicolor. A double-blind randomized controlled trial was carried out in the dermatological clinic of Gorgan, northern Iran, between April 2006 and May 2007. All consecutive patients with pityriasis versicolor were included and randomly divided into two groups. In the first group (G1), patients underwent treatment with a single dose of fluconazole capsule (400 mg) and placebo cream. In the second group (G2), patients underwent treatment with clotrimazole cream (twice daily) and placebo capsule. The course of treatment was 2 weeks. All subjects were re-evaluated 2, 4 and 12 weeks after the end of the therapeutic course. After 2 weeks, the rate of complete resolution of disease was significantly higher in G2 than G1 (49.1% vs 30%). After 4 weeks, 41 patients (81.2%) of G1 and 52 patients (94.9%) of G2 showed complete resolution. After 12 weeks, 46 patients (92%) in G1 and 45 patients (81.8%) in G2 showed complete resolution. Recurrence rate in G1 and G2 were 6% and 18.2%, respectively. No complications were seen in either group. In this study, clinical response at week 4 was greater in the clotrimazole group than the fluconazole group. Recurrence at week 12 after treatment was less with oral fluconazole than clotrimazole cream. So, for better evaluation, more studies need to be done.

  13. Adult pityriasis lichenoides-like mycosis fungoides: a clinical variant of mycosis fungoides.

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    de Unamuno Bustos, Blanca; Ferriols, Amparo P; Sánchez, Rosa B; Rabasco, Ana G; Vela, Carmen G; Piris, Miguel A; Alegre de Míquel, Víctor

    2014-11-01

    Mycosis fungoides (MF) is the most frequent type of cutaneous T cell lymphoma. Its clinicopathological spectrum is wide, and the resulting diversity makes it difficult to establish a differential diagnosis among pityriasis lichenoides (PL), lymphomatoid papulosis (LyP), and atypical MF. This study describes four patients with longstanding PL-like lesions, in whom clinicopathological correlations contributed towards the establishment of definitive diagnoses of MF. The clinical histories of the four patients were reviewed. Skin biopsies were processed by hematoxylin and eosin staining and immunohistochemical techniques. Disease spread was studied according to laboratory tests, complete blood counts, biochemical parameters, lactate dehydrogenase, lymphocyte populations, and Sézary cells. Thoracoabdominopelvic computed tomography was performed. The four patients included two women and two men, aged 35-70 years, all of whom had chronic skin lesions located mainly on the trunk and extremities. In three patients, initial clinicopathological correlations led to the diagnosis of PL; further biopsies were required to diagnose MF. In all patients, the atypical lymphocytic infiltrate showed a lichenoid or perivascular distribution with focal epidermotropism and parakeratosis. All cases proved positive for CD4 and CD3, and negative for CD20, CD8, and CD30. Polymerase chain reaction showed monoclonal-type T cells in one and polyclonal infiltrates in three patients. All patients were initially treated with topical corticosteroids and photochemotherapy. None of the treatments proved completely successful, but subsequent tests have yielded no evidence of disease progression in any patient. In patients with clinical features of longstanding PL and histological findings consistent with MF, differential diagnosis must include PL, LyP, and papular MF. As some forms of PL evolve towards MF and PL-like forms of MF, these patients should undergo regular follow-up and repeated biopsies

  14. Evaluation of pityriasis versicolor in prisoners: A cross-sectional study

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    Salahi-Moghaddam Abdoreza

    2009-01-01

    Full Text Available Background: Pityriasis versicolor (PV is a mild but recurrent superficial fungal infection of stratum corneum. Many predisposing factors such as late teen and young adulthood age, tropical and subtropical climate (and to a lesser extent temperate climate, immunosuppression, malnutrition, use of oral contraceptives, hyperhidrosis, poor hygiene and a few other factors have been proposed for this condition. Aim: Regarding these probable and possible risk factors, we felt that jail is a unique population which can be affected by this infection and therefore we decided to evaluate some aspects of this infection in this population. Methods: In this cross-sectional study in male prisoners of Bandarabbas city, 230 prisoners were randomly selected. One hundred and five (45.67% of them were diagnosed to be infected. They were also evaluated regarding age, duration of being imprisoned, skin color, site of lesion and its pigmentation change and any concomitant clinical manifestation such as pruritis, burning or cebure. Chi-square test or Fisher′s exact test was used for data analysis. Results: Mean age of infected population was 31.62 ± 8.67 years while peak incidence of PV was in 28-32 years age group. The most common color change was hypopigmentation. No case of PV hyperpigmentation was seen. We could not also observe any association between skin color and duration of being imprisoned with the frequency of infection. Conclusion: There seems to be no difference between pattern of infection in the general population and prisoners′ population in the aspects evaluated.

  15. 萎缩性花斑糠疹%Atrophying pityriasis versicolor

    Institute of Scientific and Technical Information of China (English)

    胡燕; 朱小红; 陈浩; 张海平; 吉津; 杨莉佳

    2013-01-01

    A 26-year-old woman presented with scaly atrophic erythema on the chest and abdomen for nearly 2 years.Direct microscopic examination of the lesion scrapings revealed numerous stubby hyphae and clustered spores.Periodic acid-Schiff (PAS) staining of the biopsy tissue showed the presence of numerous hyphae and spores in the horny layer.The stain for elastic fibers revealed that the number of elastic fibers decreased,and some elastic fibers became fine and disrupted.The patient was diagnosed with atrophying pityriasis versicolor.The lesions subsided and direct microscopic examination was negative after 1-week treatment with oral itraconazole of 200 mg once daily and 4-week treatment with topical 2% sertaconazole cream.%患者女,26岁.因胸腹部鳞屑性红斑伴萎缩近2年就诊.取皮屑直接镜检,见较多粗短的菌丝及成簇孢子.皮损组织病理检查,过碘酸雪夫(PAS)染色见角质层内较多菌丝和孢子.弹力纤维染色示弹力纤维减少,部分弹力纤维纤细、断裂.诊断:萎缩性花斑糠疹.治疗:口服伊曲康唑胶囊200mg/d共1周,外用2%舍他康唑乳膏4周,皮疹消退,真菌直接镜检复查阴性.

  16. Identification of Malassezia species from pityriasis versicolor lesions with a new multiplex PCR method.

    Science.gov (United States)

    Vuran, Emre; Karaarslan, Aydın; Karasartova, Djursun; Turegun, Buse; Sahin, Fikret

    2014-02-01

    Despite the fact that a range of molecular methods have been developed as tools for the diagnosis of Malassezia species, there are several drawbacks associated with them, such as inefficiency of differentiating all the species, high cost, and questionable reproducibility. In addition, most of the molecular methods require cultivation to enhance sensitivity. Therefore, alternative methods eliminating cultivation and capable of identifying species with high accuracy and reliability are needed. Herein, a multiplex polymerase chain reaction (PCR)-based method was especially developed for the detection of eleven Malassezia species. The multiplex PCR was standardized by incorporating a consensus forward primer, along with Malassezia species-specific reverse primers considering the sizes of the PCR products. In the method, the multiplex-PCR primer content is divided into three parts to circumvent the problem of increased nonspecific background resulting from the use of a large number of primers. DNA extraction protocol described by Harju and colleagues was modified using liquid nitrogen instead of -80 °C to break down the yeast membrane. By a modified extraction procedure followed by multiplex PCR and electrophoresis, the method enables identification and differentiation of Malassezia species from both of the samples obtained directly from skin and yeast colonies grown in culture. Fifty-five patients who were confirmed with pityriasis versicolor were enrolled in the study. Multiplex PCR detected and differentiated all 55 samples obtained directly from the patients' skin. However, 50 out of 55 samples yielded Malassezia colony in the culture. In addition, eight of 50 colonies were misdiagnosed or not completely differentiated by conventional methods based on the sequence analysis of eight colonies. The method is capable of identifying species with high accuracy and reliability. In addition, it is simple, quick, and cost-effective. More importantly, the method works

  17. Pityriasis lichenoides chronica%慢性苔藓样糠疹

    Institute of Scientific and Technical Information of China (English)

    尹晓慧; 张艳; 曲晓滨; 邢庆涛

    2014-01-01

    Pityriasis lichenoides chronica (PLC) is a papulosquamous dermatosis with unknown etiology.It usually occurs in children and youth,occasionally in neonates and the elderly,and more frequently in females than in males.There are three main hypotheses on its pathogenesis,namely,infection theory,lymphocyte proliferation theory and immune complex deposition theory.Histopathological manifestations of PLC are not specific.Some novel ideas are introduced in this article for the treatment of PLC.In addition to traditional systemic antibiotics,topical corticosteroids and photochemotherapy,methotrexate,cyclosporine,dapsone and acitretin also have good therapeutic effects on PLC.%慢性苔藓样糠疹是一种病因不明的丘疹鳞屑性皮肤病,儿童和青年人好发,偶见于新生儿和老人,女性发病高于男性.该病的发病机制主要有3种假说,感染学说、淋巴细胞增殖学说、免疫复合物沉积学说.慢性苔藓样糠疹的组织病理无特异性.对慢性苔藓样糠疹的治疗提供了一些新观点,除系统应用抗生素、局部外用糖皮质激素及光化学疗法外,甲氨蝶呤、环孢素、氨苯砜和阿维A等对慢性苔藓样糠疹也有较好的疗效.

  18. Effects of Cornus mas L. and Morus rubra L. extracts on penicillin-induced epileptiform activity: an electrophysiological and biochemical study.

    Science.gov (United States)

    Tubaş, Filiz; Per, Sedat; Taşdemir, Abdulkadir; Bayram, Ayşe Kaçar; Yıldırım, Mehmet; Uzun, Aydın; Saraymen, Recep; Gümüş, Hakan; Elmalı, Ferhan; Per, Hüseyin

    2017-01-01

    Traditionally, Morus rubra L. (Moraceae) (red mulberry) and Cornus mas L. (Cornacea) (cornelian cherry) fruits are eaten fresh and are also used in marmalades, juices, jam, natural dyes in Turkey and are believed to have beneficial effects in case of multiple health issues such as antipyretic, diarrhea and intestinal parasites. However, the effects of M. rubra and C. mas on epilepsy has not been known. This study evaluates the effects of M. rubra and C. mas extracts on penicillin-induced epileptiform activity. Sixty Wistar rats randomly divided into ten groups (n=6): control, sham, penicillin, penicillin+M. rubra extract (2.5, 5, 10, 20 mg/kg) and penicillin+C. mas extract (2.5, 5, 10 mg/kg). Epileptiform activity was induced by using penicillin (500 IU, i.c.) and electrocorticogram records (150 min) were obtained. Also, biochemical analysis in blood samples were evaluated. According to the electrocorticogram analysis, the effective dose was detected as 10 mg/kg for both C. mas and M. rubra. This dose decreased the spike frequencies of convulsions while amplitude wasn't changed by both substances. In erythrocyte studies, there were significant differences regarding nitric oxide in the control, sham and penicillin groups. There were significant differences regarding malondialdehyde in all groups. In the plasma, there were significant differences among groups regarding xanthine oxidase in the penicillin‑C. mas and penicillin‑M. rubra groups. There were differences regarding malondialdehyde in the penicillin-C. mas and M. rubra-C. mas groups. Both extracts reduced the frequency of epileptiform activity. After administration of the extracts malondialdehyde levels decreased also in both erythrocytes and plasma.

  19. Phytochemical Content of Some Black (Morus nigra L. and Purple (Morus rubra L. Mulberry Genotypes

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    Murat Tosun

    2010-01-01

    Full Text Available Bright black (Morus nigra and purple mulberry (Morus rubra are particularly desirable fruits in Turkey. More recently, the interest in these bright black and purple mulberry fruits has also increased because of the popularization of healthy properties of these fruits. The study was carried out in 2008 aiming to determine the antioxidant activity (ferric reducing ability of plasma, FRAP, total phenolic, total anthocyanin, mineral, soluble solid, vitamin C, and total acid content of four black and four purple mulberry genotypes grown in Turkey. The results show that black mulberry genotypes have a higher bioactive content than purple mulberry genotypes. The average total phenolic content and total anthocyanins of black mulberry genotypes were 2149 μg of gallic acid equivalent (GAE per g and 719 μg of cyanidin 3-glucoside equivalent (Cy 3-glu per g of fresh mass. In purple mulberry, these values were for GAE 1690 μg/g and for Cy 3-glu 109 μg/g on fresh mass basis. The average antioxidant activity of black mulberry genotypes was also found to be higher than that of the purple ones according to FRAP assay (Trolox equivalent (TE per fresh mass of black and purple mulberries was 13.35 and 6.87 μmol/g, respectively.

  20. THE ALLELOPATHIC INFLUENCE OF TARAXACUM OFFICINALE ON THE INITIAL GROWTH AND DEVELOPMENT OF FESTUCA RUBRA L.

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    Jolanta Jankowska

    2014-01-01

    Full Text Available Common dandelion (Taraxacum officinale F.H. Wigg is perennial plant often stepping out in very large quantity in the sward of natural meadows. This species expands, enlarging its population very quickly. In the literature there is the lack of data related to influences of the common dandelion on plants growing in it’s neighbourhood. It is also unknown why this species creates large clusters. It may compete with different plants through the allelopatic influence. Therefore, the aim of this work was to test of the influence of water extracts from leaves and from the roots of common dandelion (Taraxacum officinale as well as soil extracts from the radicular layer of this species on the germination of the seeds and the initial growth of Red fescue (Festuca rubra L.. The investigative material came from leaves and roots of Taraxacum officinale and soil coming from the radicular layer of this species. It was applied most often in biotest experiments on germination. Red fescue was the tested plant. The germination energy of red fescue was the most braked through the plant extracts prepared from roots and leaves of Taraxacum officinale.

  1. In vitro Anti-Thrombotic Activity of Extracts from Blacklip Abalone (Haliotis rubra Processing Waste

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    Hafiz Ansar Rasul Suleria

    2016-12-01

    Full Text Available Waste generated from the processing of marine organisms for food represents an underutilized resource that has the potential to provide bioactive molecules with pharmaceutical applications. Some of these molecules have known anti-thrombotic and anti-coagulant activities and are being investigated as alternatives to common anti-thrombotic drugs, like heparin and warfarin that have serious side effects. In the current study, extracts prepared from blacklip abalone (Haliotis rubra processing waste, using food grade enzymes papain and bromelain, were found to contain sulphated polysaccharide with anti-thrombotic activity. Extracts were found to be enriched with sulphated polysaccharides and assessed for anti-thrombotic activity in vitro through heparin cofactor-II (HCII-mediated inhibition of thrombin. More than 60% thrombin inhibition was observed in response to 100 μg/mL sulphated polysaccharides. Anti-thrombotic potential was further assessed as anti-coagulant activity in plasma and blood, using prothrombin time (PT, activated partial thromboplastin time (aPTT, and thromboelastography (TEG. All abalone extracts had significant activity compared with saline control. Anion exchange chromatography was used to separate extracts into fractions with enhanced anti-thrombotic activity, improving HCII-mediated thrombin inhibition, PT and aPTT almost 2-fold. Overall this study identifies an alternative source of anti-thrombotic molecules that can be easily processed offering alternatives to current anti-thrombotic agents like heparin.

  2. [Effects of simulated acid rain on water physiological characteristics of Myrica rubra seedlings].

    Science.gov (United States)

    Yaho, Zhao-bin; Jiang, Hong; Yu, Shu-quan; Lu, Mei-juan

    2011-08-01

    Taking the seedlings of typical subtropical economic tree species Myrica rubra in Zhejiang Province as test materials, a pot experiment was conducted to study their water physiological characteristics under effects of simulated acid rain (pH 2.5 and pH 4.0), with water (pH 5.6) as the control. Season, year, and acid rain all had significant effects on the photosynthetic rate (Pn). Among the treatments, the Pn had a greater difference in summer than in spring and autumn, and was higher in treatment acid rain (pH 4.0). Season, year, acid rain, and the interactions of season and year and of the three factors had significant effects on the stomata conductance (Gs), and also, the Gs had a greater difference among the treatments in summer than in spring and autumn. Acid rain had inhibitory effect on Gs. Season, year, acid rain, and the interactions of season and year and of season and acid rain affected the transpiration rate (Tr) significantly. Same as Pn and Gs, the Tr had a greater difference among the treatments in summer than in spring and autumn. Acid rain (pH 2.5) had the strongest inhibitory effect on Tr. Acid rain and the interactions of season and year and of season and acid rain had significant effects on the water use efficiency (WUE), and acid rain (pH 2.5) had definitely positive effect on the WUE.

  3. Ácido 15-desmetilisoplumierídeo, um novo iridóide isolado das cascas de Plumeria rubra e do látex de Himatanthus sucuuba 15-demethylisoplumieride acid, a new iridoid isolated from the bark of Plumeria rubra and latex of Himatanthus sucuuba

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    Alaide de Sá Barreto

    2007-10-01

    Full Text Available Himatanthus sucuuba and Plumeria rubra are used in folk medicine in Brazil to treat various ailments. The isolation of the new iridoid 15-demethylisoplumieride from the bark of Plumeria rubra L. var. acutifolia (Ait Woodson and latex of Himatanthus sucuuba (Spruce Woodson is reported. Other iridoid glycosides were obtained from both plants. The structures of these substances were elucidated by spectral analysis and comparison with data already reported.

  4. Novos aspectos na evolução clínica da pitiríase versicolor New aspects in the clinical course of pityriasis versicolor

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    Valéria Maria de Souza Framil

    2011-12-01

    Full Text Available FUNDAMENTO: A pitiríase versicolor é uma doença infecciosa causada por várias espécies de Malassezia com uma tendência a se tornar recidivante ou crônica. OBJETIVOS: Este trabalho foi conduzido na tentativa de conhecer a evolução clínica da pitiríase versicolor em relação ao número de recidivas após um tratamento adequado no período de 12 meses e correlacionar o número de recidivas com as espécies de Malassezia isoladas. MATERIAL E MÉTODOS: Cento e dois pacientes com diagnóstico clínico e laboratorial de pitiríase versicolor foram acompanhados por um período de 12 meses para observarmos o número de recidivas da doença. RESULTADOS: A pitiríase versicolor, após um tratamento adequado, apresentou três tipos de evolução clínica num período de 12 meses: pitiríase versicolor sem nenhum episódio de recidiva (32,35%; pitiríase versicolor recidivante, com um a quatro episódios de recidiva (52,94% devidos a fatores de predisposição relacionados; e pitiríase versicolor crônica, com mais de quatro episódios de recidiva (14,70% sem nenhuma relação com fatores de predisposição. CONCLUSÕES: A pitiríase versicolor apresentou uma evolução clínica de acordo com o número de episódios de recidiva da doença analisados durante um período de 12 meses que pode ser considerada da seguinte maneira: pitiríase versicolor com cura clínica e micológica, pitiríase versicolor recidivante e pitiríase versicolor crônica.BACKGROUND: Pytiriasis versicolor is an infectious disease caused by several Malassezia species which has a tendency to become relapsing or chronic. OBJECTIVES: This study was conducted in an attempt to investigate the clinical course of pityriasis versicolor with regard to the number of relapses after a 12-month therapy and correlate this number with isolates of Malassezia species. MATERIAL AND METHODS: 102 patients with clinical and laboratory diagnosis of pityriasis versicolor were monitored for 12

  5. [Qualitative and quantitative analysis of major constituents of Paeoniae Radix Alba and Paeoniae Radix Rubra by HPLC-DAD-Q-TOF-MS/MS].

    Science.gov (United States)

    Liu, Jie; Chen, Lin; Fan, Cai-rong; Li, Huang; Huang, Ming-qing; Xiang, Qing; Xu, Wen; Xu, Wei; Chu, Ke-dan; Lin, Yu

    2015-05-01

    In order to explore the differences of chemical constituents of Paeoniae Radix Alba and Paeoniae Radix Rubra, a qualitative analytical method of liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (HPLC-Q-TOF-MS/MS) was developed for identification of multi-constituents and an HPLC-DAD analytical method was developed for simultaneously determining 14 major compounds (gallic acid, protocatechuic acid, paeoniflorin sulfonate, protocatechuic aldehyde, methyl gallate, oxypaeoniflorin, catechin, albiflorin, and paeoniflorin, ethyl gallate, benzoic acid, pentagaloylglucose, benzoyl-paeoniflorin, and paeonol) in Paeoniae Radix Alba and Paeoniae Radix Rubra. Q-TOF/MS qualitative analysis was performed under negative ion mode and inferred 38 components of Paeoniae Radix Alba and 30 components of Paeoniae Radix Rubra. HPLC-DAD quantitative method result showed the contents of 8 ingredients were different between Paeoniae Radix Alba and Paeoniae Radix Rubra. The results indicated that the new approach was applicable in qualitative and quantitative quality control of Paeoniae Radix Alba and Paeoniae Radix Rubra.

  6. The Hybrid Strategy of Thermoactinospora rubra YIM 77501T for Utilizing Cellulose as a Carbon Source at Different Temperatures

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    Yi-Rui Yin

    2017-05-01

    Full Text Available Thermoactinospora rubra YIM 77501T is an aerobic, Gram-positive, spore-forming and cellulose degrading thermophilic actinomycete isolated from a sandy soil sample of a volcano. Its growth temperature range is 28–60°C. The genomic sequence of this strain revealed that there are 27 cellulase genes belonging to six glycoside hydrolase families. To understand the strategy that this strain uses to utilize carbon sources such as cellulose at different temperatures, comparative transcriptomics analysis of T. rubra YIM 77501T was performed by growing it with cellulose (CMC and without cellulose (replaced with glucose at 30, 40, and 50°C, respectively. Transcriptomic analyses showed four cellulase genes (TrBG2, TrBG3, TrBG4, and ThrCel6B were up-regulated at 30, 40, and 50°C. The rate of gene expression of TrBG2, TrBG3, TrBG4, and ThrCel6B were 50°C > 30°C > 40°C. One cellulase gene (TrBG1 and two cellulase genes (TrBG5 and ThrCel6A were up-regulated only at 30 and 50°C, respectively. These up-regulated cellulase genes were cloned and expressed in Escherichia coli. The enzymatic properties of up-regulated cellulases showed a variety of responses to temperature. Special up-regulated cellulases TrBG1 and ThrCel6A displayed temperature acclimation for each growth condition. These expression patterns revealed that a hybrid strategy was used by T. rubra to utilize carbon sources at different temperatures. This study provides genomic, transcriptomics, and experimental data useful for understanding how microorganisms respond to environmental changes and their application in enhancing cellulose hydrolysis for animal feed and bioenergy production.

  7. Reproduction and development in Halocaridina rubra Holthuis, 1963 (Crustacea: Atyidae) clarifies larval ecology in the Hawaiian anchialine ecosystem.

    Science.gov (United States)

    Havird, Justin C; Vaught, Rebecca C; Weese, David A; Santos, Scott R

    2015-10-01

    Larvae in aquatic habitats often develop in environments different from those they inhabit as adults. Shrimp in the Atyidae exemplify this trend, as larvae of many species require salt or brackish water for development, while adults are freshwater-adapted. An exception within the Atyidae family is the "anchialine clade," which are euryhaline as adults and endemic to habitats with subterranean fresh and marine water influences. Although the Hawaiian anchialine atyid Halocaridina rubra is a strong osmoregulator, its larvae have never been observed in nature. Moreover, larval development in anchialine species is poorly studied. Here, reproductive trends in laboratory colonies over a 5-y period are presented from seven genetic lineages and one mixed population of H. rubra; larval survivorship under varying salinities is also discussed. The presence and number of larvae differed significantly among lineages, with the mixed population being the most prolific. Statistical differences in reproduction attributable to seasonality also were identified. Larval survivorship was lowest (12% settlement rate) at a salinity approaching fresh water and significantly higher in brackish and seawater (88% and 72%, respectively). Correlated with this finding, identifiable gills capable of ion transport did not develop until metamorphosis into juveniles. Thus, early life stages of H. rubra are apparently excluded from surface waters, which are characterized by lower and fluctuating salinities. Instead, these stages are restricted to the subterranean (where there is higher and more stable salinity) portion of Hawaii's anchialine habitats due to their inability to tolerate low salinities. Taken together, these data contribute to the understudied area of larval ecology in the anchialine ecosystem. © 2015 Marine Biological Laboratory.

  8. Frankia and Alnus rubra canopy roots: an assessment of genetic diversity, propagule availability, and effects on soil nitrogen.

    Science.gov (United States)

    Kennedy, Peter G; Schouboe, Jesse L; Rogers, Rachel H; Weber, Marjorie G; Nadkarni, Nalini M

    2010-02-01

    The ecological importance of microbial symbioses in terrestrial soils is widely recognized, but their role in soils that accumulate in forest canopies is almost entirely unknown. To address this gap, this study investigated the Frankia-Alnus rubra symbiosis in canopy and forest floor roots at Olympic National Park, WA, USA. Sixteen mature A. rubra trees were surveyed and Frankia genetic diversity in canopy and forest floor nodules was assessed with sequence-based nifH analyses. A seedling bioassay experiment was conducted to determine Frankia propagule availability in canopy and forest floor soils. Total soil nitrogen from both environments was also quantified. Nodules were present in the canopies of nine of the 16 trees sampled. Across the study area, Frankia canopy and forest floor assemblages were similar, with both habitats containing the same two genotypes. The composition of forest floor and canopy genotypes on the same tree was not always identical, however, suggesting that dispersal was not a strictly local phenomenon. Frankia seedling colonization was similar in canopy soils regardless of the presence of nodules as well as in forest floor soils, indicating that dispersal was not likely to be a major limiting factor. The total soil nitrogen of canopy soils was higher than that of forest floor soils, but the presence of Frankia nodules in canopy soils did not significantly alter soil nitrogen levels. Overall, this study indicates that the Frankia-A. rubra symbiosis is similar in canopy and forest floor environments. Because canopy roots are exposed to different environmental conditions within very small spatial areas and because those areas can be easily manipulated (e.g., fertilizer or watering treatments), they present microbial ecologists with a unique arena to examine root-microbe interactions.

  9. Organic matter contribution to soil fertility improvement and maintenance in red Alder (Alnus rubra) silvopastoral systems

    Institute of Scientific and Technical Information of China (English)

    Ronnie M. Mmolotsi; Zewge Teklehaimanot

    2008-01-01

    An investigation was conducted to quantify fine roots and roots nodules over the four seasons in forestry and agroforestry alder (Alnus rubra) stands in North Wales. Soil samples collected in each season were excavated at three sampling points (0.30 m, 0.57 m and 1.00 m distance from the base of each tree) from nine trees of the agroforestry and forestry plots. Result showed that the density of live fine root had significant differences in between seasons and treatments (P < 0.001). The mean weight density of live fine root over the four seasons in agroforestry and forestry was 0.27±0.01 kg·m-3 and 0.54±0.03 kg·m-3, respectively. Weight density of dead root in each system remained constant throughout the year. The mean weight density of dead root was also significantly different (P < 0.01) between forestry and agroforestry systems. Weight density of live and dead root nodule was both constant throughout the year and between the different sampling distances. The mean weight densities of live and dead root nodule over the four seasons were 0.09±0.03 kg·m-3 and 0.05±0.03 kg·m-3 in agroforestry and 0.08±0.02 kg·m-3 and 0.03±0.01 kg·m-3 in the forestry plots, respectively.

  10. Steep Decline and Cessation in Seed Dispersal by Myrmica rubra Ants.

    Science.gov (United States)

    Bologna, Audrey; Detrain, Claire

    2015-01-01

    Myrmecochorous diaspores bear a nutrient-rich appendage, the elaiosome, attractive to ant workers that retrieve them into the nest, detach the elaiosome and reject the seed intact. While this interaction is beneficial for the plant partner by ensuring its seed dispersal, elaiosome consumption has various effects -positive, negative or none - on ants' demography and survival, depending on both the ant/plant species involved. In this context, the contribution of ants to seed dispersal strongly varies according to the ant/plant pairs considered. In this paper, we investigate whether the dynamics of myrmecochory also vary on a temporal scale, for a given pair of partners: Myrmica rubra ants and Viola odorata seeds. During their first encounter with seeds, ants collect all the diaspores and eat the majority of elaiosomes. Both the harvesting effort and the elaiosome consumption decline when seeds are offered on the next week and completely cease for the following weeks. This is related to a decrease in the number of foragers reaching the food source, as well as to a reduced probability for an ant contacting a seed to retrieve it. Seed retrieval is not reactivated after seven weeks without any encounter with V. odorata seeds. By contrast, naive ant colonies only fed with fruit flies do not show a decline of prey harvesting of which the speed of retrieval even increases over the successive weeks. Myrmecochory may thus be labile at the scale of a fruiting season due to the ability of ants to steeply tune and cease for several months the harvesting of these seemingly poorly rewarding items and to maintain cessation of seed exploitation. The present study emphasizes the importance of a long-lasting follow up of the myrmecochory process, to assess the stability of this ant-plant partnership and to identify mechanisms of adaptive harvesting in ants.

  11. Transcriptomic analysis of Chinese bayberry (Myrica rubra fruit development and ripening using RNA-Seq

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    Feng Chao

    2012-01-01

    Full Text Available Abstract Background Chinese bayberry (Myrica rubra Sieb. and Zucc. is an important subtropical fruit crop and an ideal species for fruit quality research due to the rapid and substantial changes that occur during development and ripening, including changes in fruit color and taste. However, research at the molecular level is limited by a lack of sequence data. The present study was designed to obtain transcript sequence data and examine gene expression in bayberry developing fruit based on RNA-Seq and bioinformatic analysis, to provide a foundation for understanding the molecular mechanisms controlling fruit quality changes during ripening. Results RNA-Seq generated 1.92 G raw data, which was then de novo assembled into 41,239 UniGenes with a mean length of 531 bp. Approximately 80% of the UniGenes (32,805 were annotated against public protein databases, and coding sequences (CDS of 31,665 UniGenes were determined. Over 3,600 UniGenes were differentially expressed during fruit ripening, with 826 up-regulated and 1,407 down-regulated. GO comparisons between the UniGenes of these two types and interactive pathways (Ipath analysis found that energy-related metabolism was enhanced, and catalytic activity was increased. All genes involved in anthocyanin biosynthesis were up-regulated during the fruit ripening processes, concurrent with color change. Important changes in carbohydrate and acid metabolism in the ripening fruit are likely associated with expression of sucrose phosphate synthase (SPS and glutamate decarboxylase (GAD. Conclusions Mass sequence data of Chinese bayberry was obtained and the expression profiles were examined during fruit ripening. The UniGenes were annotated, providing a platform for functional genomic research with this species. Using pathway mapping and expression profiles, the molecular mechanisms for changes in fruit color and taste during ripening were examined. This provides a reference for the study of complicated

  12. Steep Decline and Cessation in Seed Dispersal by Myrmica rubra Ants.

    Directory of Open Access Journals (Sweden)

    Audrey Bologna

    Full Text Available Myrmecochorous diaspores bear a nutrient-rich appendage, the elaiosome, attractive to ant workers that retrieve them into the nest, detach the elaiosome and reject the seed intact. While this interaction is beneficial for the plant partner by ensuring its seed dispersal, elaiosome consumption has various effects -positive, negative or none - on ants' demography and survival, depending on both the ant/plant species involved. In this context, the contribution of ants to seed dispersal strongly varies according to the ant/plant pairs considered. In this paper, we investigate whether the dynamics of myrmecochory also vary on a temporal scale, for a given pair of partners: Myrmica rubra ants and Viola odorata seeds. During their first encounter with seeds, ants collect all the diaspores and eat the majority of elaiosomes. Both the harvesting effort and the elaiosome consumption decline when seeds are offered on the next week and completely cease for the following weeks. This is related to a decrease in the number of foragers reaching the food source, as well as to a reduced probability for an ant contacting a seed to retrieve it. Seed retrieval is not reactivated after seven weeks without any encounter with V. odorata seeds. By contrast, naive ant colonies only fed with fruit flies do not show a decline of prey harvesting of which the speed of retrieval even increases over the successive weeks. Myrmecochory may thus be labile at the scale of a fruiting season due to the ability of ants to steeply tune and cease for several months the harvesting of these seemingly poorly rewarding items and to maintain cessation of seed exploitation. The present study emphasizes the importance of a long-lasting follow up of the myrmecochory process, to assess the stability of this ant-plant partnership and to identify mechanisms of adaptive harvesting in ants.

  13. Topical management of striae distensae (stretch marks): prevention and therapy of striae rubrae and albae.

    Science.gov (United States)

    Ud-Din, S; McGeorge, D; Bayat, A

    2016-02-01

    Striae distensae (SD) are common dermal lesions, with significant physical and psychological impact. Many therapeutic modalities are available but none can completely eradicate SD. The most common therapy is the application of topicals used both therapeutically and prophylactically. Even though there are many commercially available topical products, not all have sufficient level of evidence to support their continued use in SD. The aim here was to assess the evidence for the use of topicals in SD and to propose a structured approach in managing SD. A systematic search of published literature and manufacturer website information for topicals in SD was carried out. The results showed that there are few studies (n = 11) which investigate the efficacy of topicals in management of SD. Trofolastin and Alphastria creams demonstrated level-2 evidence of positive results for their prophylactic use in SD. Additionally, tretinoin used therapeutically showed varying results whilst cocoa butter and olive oil did not demonstrate any effect. Overall, there is a distinct lack of evidence for each topical formulation. The majority of topicals failed to mention their effect on early vs. later stages of SD (striae rubrae compared to striae albae) and their role in both prevention and treatment. In conclusion, there is no topical formulation, which is shown to be most effective in eradicating or improving SD. A structured approach in identification and targeted management of symptoms and signs with the appropriate topical is required. Randomized controlled trials are necessary to assess the efficacy of topical products for treatment and prevention of different stages of SD.

  14. Musa chunii Hakkinen, a new species (Musaceae) from Yunnan,China and taxonomic identity of Musa rubra

    Institute of Scientific and Technical Information of China (English)

    Markku H(A)KKINEN

    2009-01-01

    The center of diversity of the genus Musa (Musaceae) is in Southeast Asia, a region not studied in detail and where new species and varieties continue to be reported. A new wild banana species, M. chunii Hakki-nen from Yunnan, China is described and illustrated based on observed morphological characteristics in the field. This extremely rare new species was only found in Tongbiguan Nature Reserve, Dehong District, West Yunnan. A key to M. chunii and related taxa is provided. In addition, critical notes regarding M. rubra Kurz identity are given.

  15. To treat or not to treat? Management of guttate psoriasis and pityriasis rosea in patients with evidence of group A Streptococcal infection.

    Science.gov (United States)

    Krishnamurthy, Karthik; Walker, Ashley; Gropper, Charles A; Hoffman, Cindy

    2010-03-01

    The association between guttate psoriasis and pityriasis rosea with Streptococcus pyogenes (S. pyogenes) is well established in the literature; however treatment guidelines and necessity have not been clarified with respect to the infectious etiology. Also, the exact role of Streptococcus in the immunopathogenesis of these entities, and the associated risk of development of scarlet fever and poststreptococcal sequelae, are not centrally reported. No single report or case series definitively establishes the coexistence between guttate psoriasis and post-streptococcal sequelae in the same patient, supporting the theories of autoimmune protection conferred between these entities. Laboratory investigations and treatment of Streptococcus in the setting of guttate psoriasis are not necessary, as anti-streptococcal treatment does not significantly modify the course of cutaneous disease, and there is no theoretical or documented risk of post-streptococcal sequelae. However, due to minimal data, antibiotics may still have a role in pityriasis rosea.

  16. Cell-mediated immune responses to Malassezia furfur serovars A, B and C in patients with pityriasis versicolor, seborrheic dermatitis and controls.

    Science.gov (United States)

    Ashbee, H R; Ingham, E; Holland, K T; Cunliffe, W J

    1994-06-01

    It has been postulated that patients with Malassezia furfur-associated dermatoses have a deficient cell-mediated immune response to M. furfur. This study examined the cell-mediated immune responses to M. furfur serovars A, B and C of 10 patients with pityriasis versicolor and 10 age- and sex-matched controls; and 10 patients with seborrheic dermatitis and 10 age- and sex-matched controls. The responses to each serovar of M. furfur were assessed using the lymphocyte transformation assay and the leukocyte migration inhibition assay. The lymphocyte transformation responses of the patients with pityriasis versicolor to M. furfur serovars A, B and C (0/10, 6/10 and 5/10 respectively) were not significantly different from those of controls (0/10, 2/10 and 1/10). However, for patients with seborrheic dermatitis, significantly more patients' lymphocytes responded to serovars B and C (6/10 and 6/10 respectively) than those of controls (1/10 and 1/10). No patient or control responded to serovar A. In the leukocyte migration inhibition assay, the leukocytes from a greater proportion of patients with pityriasis versicolor (5/7) responded to serovar B than controls (2/10); and the leukocytes from a greater proportion of patients with seborrheic dermatitis (4/10) responded to serovar C than controls (0/9). Thus, this data did not indicate the presence of any cell-mediated immune deficiency to M. furfur in patients with pityriasis versicolor or seborrheic dermatitis, as measured by the lymphocyte transformation assay or the leukocyte migration inhibition assay. The greater responsiveness of T lymphocytes from patients may indicate that T lymphocytes might be involved in the pathogenesis of these diseases.

  17. [Distribution of pyrimidine blocks in the DNA of Brevibacterium linens, Arthrobacter globiformis, Nocardia corallina and Nocardia rubra].

    Science.gov (United States)

    Eroshina, N V; Golovlev, E L; Geĭdarov, T G; Bur'ianov, Ia I

    1975-01-01

    The nucleotide composition and the frequency of pyrimidine blocks were studied in DNA of the following bacteria: Brevibacterium linens (Weignamm, 1910) Breed, 1953; Arthrobacter globiformis (Conn, 1928) Conn et Dimmick, 1947; Nocardia corallina (Bergey et al., 1923) Waksman et Henrici, 1948; Nocardia rubra (Krassilnikov, 1949) Waksman et Henrici, 1948. These organisms are classed by some microbiologists as mycobacteria (the Mycobacteriaceae family) while other authors regard them as representatives of three families belonging to two orders. About 60 percent of all pyrimidines in DNA of these bacteria are found in the sequences pur-pyr-pur and pur-pyr-pyr-pur, the number of dipyrimidines being higher than the amount of monopyrimidine nucleotides. The content of dipyrimidine nucleotides in DNA of Nocardia corallina and Nocardia rubra is higher (16.8 mole %) than the content of dipyrimidine blocks in DNA of Brevibacterium linens and Arthrobacter globiformis, in which the quantity of dipyrimidines is almost the same (13.9 and 14.4 mole %). A new characteristic, the selected mean value, is suggested to evaluate differences in the distribution of pyrimidines in DNA.

  18. [Research of the essential oil of Plumeria rubra var. actifolia from Laos by supercritical carbon dioxide extraction].

    Science.gov (United States)

    Xiao, Xin-Yu; Cui, Long-Hai; Zhou, Xin-Xin; Wu, Yan; Ge, Fa-Huan

    2011-05-01

    The orthogonal test and the supercritical carbon dioxide fluid extraction were used for optimizing the extraction of the essential oil from Plumeria rubra var. actifolia for the first time. Compared with the steam distillation, the optimal operation parameter of extraction was as follows: extraction pressure 25 MPa, extraction temperature 45 degrees C; separator I pressure 12 MPa, separator I temperature 55 degrees C; separator II pressure 6 MPa, separator II temperature 30 degrees C. Under this condition the yield of the essential oil was 5.8927%. The components were separated and identified by GC-MS. 53 components of Plumeria rubra var. actifolia measured by SFE method were identified and determined by normalization method. The main components were 1, 6, 10-dodecatrien-3-ol, 3, 7, 11-trimethyl, benzoic acid, 2-hydroxy-, phenylmethyl ester, 1, 2-benzenedicarboxylic acid, bis(2-methylpropyl) ester,etc.. 1, 2-Benzenedicarboxylic acid, bis (2-methylpropyl) este. took up 66.11% of the total amount, and there was much difference of the results from SD method.

  19. Contrasting Hydraulic Strategies during Dry Soil Conditions in Quercus rubra and Acer rubrum in a Sandy Site in Michigan

    Directory of Open Access Journals (Sweden)

    Julia E. Thomsen

    2013-12-01

    Full Text Available Correlation analyses were carried out for the dynamics of leaf water potential in two broad-leaf deciduous tree species in a sandy site under a range of air vapor pressure deficits and a relatively dry range of soil conditions. During nights when the soil is dry, the diffuse-porous, isohydric and shallow-rooted Acer rubrum does not recharge its xylem and leaf water storage to the same capacity that is observed during nights when the soil is moist. The ring-porous, deep-rooted Quercus rubra displays a more anisohydric behavior and appears to be capable of recharging to capacity at night-time even when soil moisture at the top 1 m is near wilting point, probably by accessing deeper soil layers than A. rubrum. Compared to A. rubrum, Q. rubra displays only a minimal level of down-regulation of stomatal conductance, which leads to a reduction of leaf water potential during times when vapor pressure deficit is high and soil moisture is limiting. We determine that the two species, despite typically being categorized by ecosystem models under the same plant functional type—mid-successional, temperate broadleaf—display different hydraulic strategies. These differences may lead to large differences between the species in water relations, transpiration and productivity under different precipitation and humidity regimes.

  20. The prevalence of pityriasis versicolor in the dormitories of the Lorestan University of Medical Sciences by the three methods: skin scraping, use of scotch tape and wood’s lamp

    Directory of Open Access Journals (Sweden)

    sanaz Rostami

    2016-05-01

    Full Text Available Background : Pityriasis versicolor is a chronic, recurrent and often asymptomatic infection of stratum corneum, Which is caused by lipophilic yeasts of Malassezia. Human to human transmission through direct contact is possible. The present study aimed to assess the prevalence of pityriasis versicolor in the dormitories of the Lorestan University of Medical Sciences by the three methods: skin scraping, use of scotch tape and wood’s lamp was perfumed. Materials and Methods: In this descriptive cross-sectional study,115 students in the dormitories of the university of medical sciences were studied with the three methods:skin scraping, using  scotch tape and wood’s lamp. Results: Among 115 patients, 66.94% were female and 33.05% were male. The mean age was 21.38 years.25% of boys and 11.1% of girls were affected.The prevalence of  Pityriasis versicolor by  the three methods was determined 15.7%. In this study, the  most common site of infection was shoulder and neck. Conclusion: The recent study showed a high prevalence of Pityriasis versicolor in Lorestan University of  Medical Sciences students . The prevalence of pityriasis versicolor had a statistically significant difference between males and females, and was more common in females .  The pairwise comparison results obtained  from the three methods using the Kappa coefficient, scotch tape method  was the most consistent results than the other two methods.

  1. Differential effects of Radix Paeoniae Rubra (Chishao on cytokine and chemokine expression inducible by mycobacteria

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    Li James

    2011-03-01

    Full Text Available Abstract Background Upon initial infection with mycobacteria, macrophages secrete multiple cytokines and chemokines, including interleukin-6 (IL-6, IL-8 and tumor necrosis factor-α (TNF-α, to mediate host immune responses against the pathogen. Mycobacteria also induce the production of IL-10 via PKR activation in primary human monocytes and macrophages. As an anti-inflammatory cytokine, over-expression of IL-10 may contribute to mycobacterial evasion of the host immunity. Radix Paeoniae Rubra (RPR, Chishao, a Chinese medicinal herb with potentials of anti-inflammatory, hepatoprotective and neuroprotective effects, is used to treat tuberculosis. This study investigates the immunoregulatory effects of RPR on primary human blood macrophages (PBMac during mycobacterial infection. Methods The interaction of Bacillus Calmette-Guerin (BCG with PBMac was used as an experimental model. A series of procedures involving solvent extraction and fractionation were used to isolate bioactive constituents in RPR. RPR-EA-S1, a fraction with potent immunoregulatory effects was obtained with a bioactivity guided fractionation scheme. PBMac were treated with crude RPR extracts or RPR-EA-S1 before BCG stimulation. The expression levels of IL-6, IL-8, IL-10 and TNF-α were measured by qPCR and ELISA. Western blotting was used to determine the effects of RPR-EA-S1 on signaling kinases and transcriptional factors in the BCG-activated PBMac. Results In BCG-stimulated macrophages, crude RPR extracts and fraction RPR-EA-S1 specifically inhibited IL-10 production while enhanced IL-8 expression at both mRNA and protein levels without affecting the expressions of IL-6 and TNF-α. Inhibition of BCG-induced IL-10 expression by RPR-EA-S1 occurred in a dose- and time-dependent manner. RPR-EA-S1 did not affect the phosphorylation of cellular protein kinases including MAPK, Akt and GSK3β. Instead, it suppressed the degradation of IκBα in the cytoplasm and inhibited the

  2. Roles of gibberellins and abscisic acid in dormancy and germination of red bayberry (Myrica rubra) seeds.

    Science.gov (United States)

    Chen, Shun-Ying; Kuo, Shing-Rong; Chien, Ching-Te

    2008-09-01

    Intact seeds from freshly harvested fruits of Myrica rubra (Sieb et Zucc.) were dormant and required 8 weeks of warm stratification followed by 12 weeks of cold stratification for germination. Exogenous application of gibberellic acid (GA(3)) to intact fresh seeds was effective in breaking dormancy, with > 70% of seeds germinating when treated with 5.2 mM GA(3) and incubated at a day/night temperature of 30/20 degrees C for 20 weeks. Removing the hard endocarp or endocarp plus seed coat of fresh seeds promoted germination, and addition of GA(3) to the embryo accelerated germination. The gibberellins GA(1) and GA(4) were more effective than GA(3) in promoting germination of seeds with the endocarp removed. Endogenous contents of GA(1), GA(3), GA(4), GA(7) and GA(20) were quantified by gas chromatography-mass spectrometry-selected ion monitoring in the endocarps, seed coats and embryos of fresh seeds treated with 5.2 mM GA(3). The content of GA(3) decreased in the endocarp during incubation, whereas GA(1) contents increased in the endocarp and seed coat. A high GA(1) content was detected in the endocarps and embryos of newly germinated seeds. We speculate that GA(3) was converted to GA(1) during incubation and that GA(1) is involved in seed germination. Endogenous abscisic acid (ABA) contents were measured in fresh seeds and in warm and cold stratified seeds. The ABA content in fresh seeds was distributed in the order endocarp > seed coat > embryo, with the content in the endocarp being about 132-fold higher than in the seed coat and embryo. Total ABA content of seeds subjected to warm or cold stratification, or both, was 8.7- to 14.0-fold lower than that of fresh seeds. Low contents of endogenous GA(1), GA(3), GA(7) and GA(20), but elevated contents of GA(4), were found in the seed coats and endocarps of warm plus cold stratified seeds and in the seed coats and embryos of newly germinated seeds. These observations, coupled with the finding that GA stimulated

  3. Draft Genome Sequence of Bacillus pumilus Strain GM3FR, an Endophyte Isolated from Aerial Plant Tissues of Festuca rubra L.

    Science.gov (United States)

    Hollensteiner, Jacqueline; Daniel, Rolf; Liesegang, Heiko; Vidal, Stefan

    2017-01-01

    ABSTRACT Here, we report the draft genome sequence of Bacillus pumilus GM3FR, an endophytic bacterium isolated from aerial plant tissues of Festuca rubra L. The draft genome consists of 3.5 Mb and harbors 3,551 predicted protein-encoding genes. The genome provides insights into the biocontrol potential of B. pumilus GM3FR. PMID:28360161

  4. Effects of NaCl salinity on nitrate uptake and partitioning of N and C in Festuca rubra L. in relation to growth rate

    NARCIS (Netherlands)

    Rubinigg, M; Elzenga, JTM; Stulen, G

    2002-01-01

    The effect of salinity on nitrate net uptake rate was studied in the moderately salt tolerant halophyte Festuca rubra L., in relation to changes in relative growth rate, root weight ratio and nitrogen and carbon partitioning. Plants were grown for 21 days on nutrient solution containing 50, 100 and

  5. Growth-inhibiting and apoptosis-inducing activities of Myricanol from the bark of Myrica rubra in human lung adenocarcinoma A549 cells.

    Science.gov (United States)

    Dai, G H; Meng, G M; Tong, Y L; Chen, X; Ren, Z M; Wang, K; Yang, F

    2014-09-25

    Myrica rubra (Lour.) Sieb. Et Zucc. is a myricaceae Myrica plant. It is a subtropical fruit tree in China and other Asian countries. The bark of M. rubra is used in Chinese folk medicine because of its antibacterial, antioxidant, anti-inflammatory, and anticancer activities. However, the mechanisms underlying such activities remain unclear. This study investigated whether or not Myricanol extracted from M. rubra bark elicits anti-cancer effects on human lung adenocarcinoma A549 cells by inducing apoptosis in vivo. Myricanol was extracted from M. rubra bark through system solvent extraction and silica gel layer column separation. The results of tritiated thymidine assay, colony formation assay, and flow cytometry indicated that Myricanol inhibited the growth of A549 cells. The effects of Myricanol on the expression of key apoptosis-related genes in A549 cells were evaluated by quantitative PCR and Western blot analyses. Myricanol significantly inhibited the growth of A549 cells in a dose-dependent manner, with a half maximal inhibitory concentration of 4.85 μg/ml. Myricanol significantly decreased colony formation and induced A549 cell apoptosis. Myricanol upregulated the expression of Caspase-3, Caspase-9, Bax, and p21 and downregulated the expression of Bcl-2 at the mRNA and protein levels. These changes were associated with apoptosis. Based on these results, we propose that Myricanol elicits growth inhibitory and cytotoxic effects on lung cancer cells. Therefore, Myricanol may be a clinical candidate for the prevention and treatment of lung cancer.

  6. Influence of overstory density on ecophysiology of red oak (Quercus rubra) and sugar maple (Acer saccharum) seedlings in central Ontario shelterwoods

    Science.gov (United States)

    William C. Parker; Daniel C. Dey

    2008-01-01

    A field experiment was established in a secondgrowth hardwood forest dominated by red oak (Quercus rubra L.) to examine the effects of shelterwood overstory density on leaf gas exchange and seedling water status of planted red oak, naturally regenerated red oak and sugar maple (Acer saccharum Marsh.) seedlings during the first...

  7. Influence of papermill sludge on growth of Medicago sativa, Festuca rubra and Agropyron trachycaulum in gold mine tailings: A greenhouse study

    Energy Technology Data Exchange (ETDEWEB)

    Green, Scott [Department of Botany, University of Manitoba, 505 Buller building, Winnipeg, Manitoba R3T 2N2 (Canada); Renault, Sylvie [Department of Botany, University of Manitoba, 505 Buller building, Winnipeg, Manitoba R3T 2N2 (Canada)], E-mail: renaults@cc.umanitoba.ca

    2008-02-15

    A greenhouse study was undertaken to determine the suitability of adding papermill sludge to neutral/alkaline gold mine tailings to improve the establishment of Festuca rubra, Agropyron trachycaulum and Medicago sativa. Festuca rubra root and shoot biomass and A. Trachycaulum shoot biomass were increased with papermill sludge amendment. The addition of papermill sludge and fertilizer drastically increased the shoot and root biomass of M. sativa (20-30 times) while A. trachycaulum and F. rubra showed a more moderate increase in growth. Photosynthetic pigment content of the leaves was higher in papermill sludge treatments than in the treatments without papermill sludge. The organic carbon content, macro-aggregate content and field capacity of the gold mine tailings were increased while the bulk density was decreased by the addition of papermill sludge. This study suggests that addition of papermill sludge and adequate fertilization can alleviate some of the adverse conditions of neutral/alkaline gold mine tailings. - Addition of papermill sludge and adequate fertilization of neutral gold mine tailings increased growth of Medicago sativa, Festuca rubra and Agropyron trachycaulum.

  8. ANÁLISIS PRELIMINAR DE LA VARIABILIDAD GENÉTICA DE ESCALLONIA ALPINA Y E. RUBRA (ESCALLONIACEAE

    Directory of Open Access Journals (Sweden)

    Santiago Morello

    2013-01-01

    Full Text Available Escallonia alpina y E. rubra (Escalloniaceae comparten su área de distribución en el sur de los Andes y se diferencian por pocos caracteres morfológicos diagnósticos, tales como la disposición de las flores y la presencia y tipo de glándulas; sin embargo, en algunas poblaciones no es posible asignar los individuos a una u otra especie. Además, se han reconocido y descrito como híbridos varias formas de transición entre ambas. El objetivo de este trabajo es examinar la variabilidad genética poblacional de Escallonia alpina y E. rubra, y analizar si se corresponde con la variabilidad morfológica observada. Se estudió la morfología en 39 individuos de cinco poblaciones sobre los que también se realizó un análisis de AFLP. Se investigó la relación entre los individuos mediante análisis de ordenación, agrupamiento y de asignación bayesiana. Además se calcularon índices de diversidad y se realizó una prueba de Man- tel. A partir del análisis morfológico, se asignaron dos poblaciones a cada especie, mientras que una población con individuos con morfología intermedia no se pudo asignar unívocamente a ninguna de las dos especies. Se observó una fuerte correspondencia entre las especies delimitadas mediante caracteres morfológicos diagnósticos tradicionales y el patrón de AFLP. La evidencia morfológica y molecular preliminar nos permitió reconocer a Escallonia alpina y E. rubra como dos especies distintas, y a una población con caracteres morfológicos y genéticos intermedios que podrían ser el resultado de flujo génico interespecífico o de una separación incompleta de linajes.

  9. Variation of equilibrium moisture content of heat-treated Couratari oblongifolia, Fraxinus excelsior, and Quercus rubra wood

    Directory of Open Access Journals (Sweden)

    Qiaofang Zhou

    2013-02-01

    Full Text Available Heat treatment may result in variation of wood equilibrium moisture content (EMC. During this study, tauari (Couratari oblongifolia, ash (Fraxinus excelsior, and oak (Quercus rubra woods were heat-treated at 190, 200, and 210ºC for 3 hours and then put into a conditioning chamber with a temperature from 30 to 75ºC and a relative humidity from 50 to 90%. The isothermal moisture adsorption curve was subsequently analyzed. Results indicated that the EMC of heat-treated wood was reduced by 23.4 to 37.4% compared to non-treated wood, but the EMC difference at different heat-treated temperatures for three hardwoods was quite small and the EMC of heat-treated wood was inversely proportional to their dry density.

  10. Isospora cardellinae n. sp. (Apicomplexa: Eimeriidae) from the red warbler Cardellina rubra (Swainson) (Passeriformes: Parulidae) in Mexico.

    Science.gov (United States)

    Salgado-Miranda, Celene; Medina, Juan Pablo; Zepeda-Velázquez, Andrea Paloma; García-Conejo, Michele; Galindo-Sánchez, Karla Patricia; Janczur, Mariusz Krzysztof; Soriano-Vargas, Edgardo

    2016-10-01

    A new coccidian species (Protozoa: Apicomplexa: Eimeriidae) collected from the red warbler Cardellina rubra (Swainson) is reported from the Nevado de Toluca National Park, Mexico. Isospora cardellinae n. sp. has subspherical oöcysts, measuring on average 26.6 × 25.4 μm, with smooth, bi-layered wall, c.1.3 μm thick. Micropyle, oöcyst residuum, and polar granule are absent. Sporocysts are ovoidal, measuring on average 19.0 × 12.0 µm, with a knob-like Stieda body, a trapezoidal sub-Stieda body and sporocyst residuum composed of scattered spherules of different sizes. Sporozoites are vermiform with one refractile body and a nucleus. This is the fourth description of an isosporoid coccidian infecting a New World warbler.

  11. Fungal endophyte (Epichloë festucae) alters the nutrient content of Festuca rubra regardless of water availability.

    Science.gov (United States)

    Vázquez-de-Aldana, Beatriz R; García-Ciudad, Antonia; García-Criado, Balbino; Vicente-Tavera, Santiago; Zabalgogeazcoa, Iñigo

    2013-01-01

    Festuca rubra plants maintain associations with the vertically transmitted fungal endophyte Epichloë festucae. A high prevalence of infected host plants in semiarid grasslands suggests that this association could be mutualistic. We investigated if the Epichloë-endophyte affects the growth and nutrient content of F. rubra plants subjected to drought. Endophyte-infected (E+) and non-infected (E-) plants of two half-sib lines (PEN and RAB) were subjected to three water availability treatments. Shoot and root biomass, nutrient content, proline, phenolic compounds and fungal alkaloids were measured after the treatments. The effect of the endophyte on shoot and root biomass and dead leaves depended on the plant line. In the PEN line, E+ plants had a greater S:R ratio than E-, but the opposite occurred in RAB. In both plant lines and all water treatments, endophyte-infected plants had greater concentrations of N, P and Zn in shoots and Ca, Mg and Zn in roots than E- plants. On average, E+ plants contained in their shoots more P (62%), Zn (58%) and N (19%) than E- plants. While the proline in shoots increased in response to water stress, the endophyte did not affect this response. A multivariate analysis showed that endophyte status and plant line impose stronger differences in the performance of the plants than the water stress treatments. Furthermore, differences between PEN and RAB lines seemed to be greater in E- than in E+ plants, suggesting that E+ plants of both lines are more similar than those of their non-infected version. This is probably due to the endophyte producing a similar effect in both plant lines, such as the increase in N, P and Zn in shoots. The remarkable effect of the endophyte in the nutrient balance of the plants could help to explain the high prevalence of infected plants in natural grasslands.

  12. Agronomic, leaf anatomy, morphology, endophyte presence and ploidy characterization of accessions of Festuca group rubra collected in northern Spain

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, J. A.; Gutierrez-Villarias, M. I.; Fernandez-Casado, M. A.; Costal-Andrade, L.; Gonzalez-Arraez, E.; Bughrara, S. S.; Afif, E.

    2008-07-01

    Fifteen accessions of Facet's group rubra collected in northern Spain were characterized and grouped into four Festuca taxa on the basis of leaf anatomy, morphology and ploidy; seven were identified as F. heteromalla; two as F. trichophylla ssp. asperifolia; two as F. nigrescens ssp. microphylla and four as F. rubra ssp. pruinosa. All the accessions and one commercial cultivar Wilma (F. nigrescens ssp. nigrescens), used as control, were established at the Mabegondo Agronomical Research Centre, A Coruna (Galicia) in a completely randomised block design with three replicates of 10 plants per accession. The plants were agronomically characterized for seven traits during 2004 and 2005. Cluster analysis was useful in identifying four clusters that described 66.5% of the phenotypic variation. Cluster 1 consisted of nine accessions with early heading, intermediate values of green colour and tolerance to crown rust in autumn and the highest seasonal growth. Cluster 2 contained two accessions with intermediate values of heading, green colour, good tolerance to crown rust in autumn and intermediate seasonal growth. Cluster 3 contained two accessions and the cultivar Wilma, which showed early heading, dark green colour, good tolerance to crown rust in autumn and spring and intermediate seasonal growth. Cluster 4 consisted of two late heading accessions with dark green colour, and the best tolerance to crown rust in autumn and intermediate seasonal growth. Thirteen of the 15 accessions (86.6%) were infected by fungal endophytes, with the degree of infection ranging from 2 to 73%. Additional key words: endophyte, fine fescues, genetic resources, hierarchical clustering, leaf sections, multivariate analysis, turf grass. (Author) 33 refs.

  13. Larvicidal activity of silver nanoparticles synthesized using Plumeria rubra plant latex against Aedes aegypti and Anopheles stephensi.

    Science.gov (United States)

    Patil, Chandrashekhar D; Patil, Satish V; Borase, Hemant P; Salunke, Bipinchandra K; Salunkhe, Rahul B

    2012-05-01

    In the present study activity of silver nanoparticles (AgNPs) synthesized using Plumeria rubra plant latex against second and fourth larval instar of Aedes aegypti and Anopheles stephensi was determined. Range of concentrations of synthesized AgNps (10, 5, 2.5, 1.25, 0.625, 0.3125 ppm) and aqueous crude latex (1,000, 500, 250, 125, 62.50, 31.25 ppm) were tested against larvae of A. aegypti and A. Stephensi. The synthesized AgNps from P. rubra latex were highly toxic than crude latex extract in both mosquito species. The LC(50) values for second and fourth larval instars after 24 h of crude latex exposure were 1.49, 1.82 ppm against A. aegypti and 1.10, 1.74 ppm against A. stephensi respectively. These figures were 181.67, 287.49 ppm against A. aegypti and 143.69, 170.58 ppm against A. stephensi respectively for crude latex extract. The mortality rates were positively correlated with the concentration of AgNPs. The characterization studies of synthesized AgNPs by UV-Vis spectrophotometry, transmission electron microscopy (TEM), Particle size analysis (PSA) and zeta potential confirmed the spherical shape and size (32-200 nm) of silver nanoparticles along with stability. Toxicity studies carried out against non-target fish species Poecilia reticulata, the most common organism in the habitats of A. aegypti and A. stephensi showed no toxicity at LC(50) and LC(90) doses of the AgNPs. This is the first report on mosquito larvicidal activity of latex synthesized nanoparticles.

  14. Anti-inflammatory, antinociceptive, and antipyretic effects of methanol extract of Cariniana rubra stem bark in animal models

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    Edson N. Santos

    2011-06-01

    Full Text Available Cariniana rubra Miers (Lecythidaceae, popularly known as "jequitibá-vermelho'', is a large Brazilian tree whose bark is used in infusion and decoction for the treatment of inflammatory conditions. This study aims to assess the anti-inflammatory, antinociceptive, and antipyretic effects of Cariniana rubra methanolic stem bark extract (EM Cr using experimental animals. Anti-inflammatory activity of EM Cr was tested on carrageenan and dextran-induced rat paw edema, carrageenan-induced pleurisy in rats and acetic acid-increase vascular permeability in mice. Antinociceptive and antipyretic activities were evaluated using acetic acid-induced writhing, formalin and hot-plate tests in mice, as well as brewer's yeast-induced pyrexia in rats. The extract inhibitied carrageenan and dextran-induced edema, reduced exudate volume and leukocyte migration on the carrageenan-induced pleurisy and on the vascular permeability increase induced by acetic acid. The EM Cr inhibited nociception on the acetic acid-induced writhing and in the second phase of formalin test, and decreased rectal temperature. It was, however, inactive against thermal nociception.Phytochemical analysis with EM Cr showed the occurrence of saponins, triterpenes, sterols and phenolic compounds. Phytosterols (β-sitosterol, stigmasterol, pentacyclic triterpenes (α- and β-amyrin as a mixture, arjunolic acid, a phytosterol glycoside (sitosterol 3-O-β-D-glucopyranoside, and triterpenoid saponins (28-β-glucopyranosyl-23-O-acetyl arjunolic acid; 3-O-β-glucopyranosyl arjunolic acid and 28-O-[α-L-Rhamnopyranosyl-(1→2-β-glucopyranosyl]-23- O-acetyl arjunolic acid were the main identified compounds. It can be presumed that EM Cr caused their effects by inhibiting the liberation and/or action of different inflammatory mediators. These findings support the traditional use of Cariniana rubra preparations to treat inflammation.Cariniana rubra Miers (Lecythidaceae, popularmente conhecido como

  15. The Use of Synchrotron Infrared Microspectroscopy in the Assessment of Cutaneous T-cell Lymphoma vs. Pityriasis lichenoides Chronica

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    El Bedewi, A.; El Anany, G; El Mofty, M; Kretlow, A; Park, S; Miller, L

    2010-01-01

    The diagnosis of cutaneous lymphomas remains a challenge for both the clinician and dermatopathologist. To differentiate between frank malignant and premalignant lymphocytes within the skin. This study was performed on 20 patients with a mean age of 50 years. They were divided into two groups: mycosis fungoides (MF) (stage IA, IB and IIA) and pityriasis lichenoides chronica (PLC). Immunophenotyping using antibodies CD3, CD4, CD8, CD20 and CD30 was performed. Synchrotron Fourier transform infrared microspectroscopy (S-FTIRM) was performed on cell nuclei to assess chemical differences between MF and PLC cases as a potential complementary screening tool. Dermal spectra of both MF and PLC were compared using principal components analysis (PCA) of the S-FTIRM data. All PLC spectra was clustered together. However, the MF spectra formed two clusters, one that grouped with the PLC and the other grouped separately. Moreover, protein and nucleic acids showed highly significant differences between MF (IIA and IB), MF (IA) and PLC. The malignant transformation within lymphocytes was identifiable through the spectroscopic analysis of protein, RNA and DNA with S-FTIRM, making it a promising tool for classifying the progression of cutaneous T-cell lymphoma.

  16. Study of the distribution of Malassezia species in patients with pityriasis versicolor and healthy individuals in Tertiary Care Hospital, Punjab

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    M Kaur

    2013-01-01

    Full Text Available Purpose: Pityriasis versicolor (PV is a chronic superficial fungal disease caused by Malassezia species. Our aim was to identify Malassezia species from PV patients and healthy individuals in Punjab. Materials and Methods: Modified Dixon agar was used as isolation culture medium. Identification was based on morphological observation and biochemical evaluation. The biochemical evaluation consisted of culture onto Sabouraud dextrose agar, catalase reaction, Tween assimilation, Cremophor EL assimilation, splitting of esculin and growth at 38 0 C. Results: Out of 58 microscopically diagnosed cases of PV, growth was obtained from 54 (93.10% cases. The most frequently isolated species were M. globosa, M. sympodialis and M. furfur which made up 51.79%, 31.42% and 18.51% of the isolated etiological agents respectively. However, the major isolate from the back of healthy individuals was M. sympodialis (47.61%, followed by M.obtusa (19.04%, M. globosa (14.20%, M. furfur (9.52%, M. pachydermatis (4.76% and M. slooffiae (4.76%. Conclusions: M. globosa in its mycelial phase was the main etiological agent, but as normal flora from the back of healthy subjects, it was found in significantly less number (P = 0.01, suggesting that the higher pathogenicity of M. globosa in terms of enzymatic endowment, might be the cause of its predominance in PV lesions.

  17. An Analysis of the Malassezia Species Distribution in the Skin of Patients with Pityriasis Versicolor in Chengdu, China

    Directory of Open Access Journals (Sweden)

    Zhen Xie

    2014-01-01

    Full Text Available Pityriasis versicolor (PV is a common clinical problem associated with Malassezia species (Malassezia spp.. Controversies remain regarding the specific species involved in the development of PV. This study analyzed the difference in Malassezia spp. distribution in lesional and nonlesional skin in Chinese PV patients. A paired design was applied. Lesional and nonlesional scales from 24 cases were collected; real-time fluorescence quantitative PCR was used to detect 10 different Malassezia spp. In lesional skin, the highest detection rates were for M. globosa (95.8%, M. restricta (91.7%, and M. sympodialis (50.0%. In nonlesional skin, the highest detection rates were for M. globosa (87.5%, M. restricta (79.2%, and M. dermatis (33.3%. A significant difference in the detection rate was only found for M. sympodialis (50.8% versus 20.8%, P=0.04. Compared with nonlesional skin, the amount of M. globosa, M. restricta, and M. sympodialis in lesional skin was significantly higher (3.8±1.3,   2.5±1.1, and 3.2±1.6 times higher, resp.. The results of this study do not indicate that M. globosa and M. restricta are directly correlated with PV development; however, M. sympodialis is more likely related to PV development in Chinese individuals.

  18. The use of synchrotron infrared microspectroscopy in the assessment of cutaneous T-cell lymphoma vs. pityriasis lichenoides chronica.

    Science.gov (United States)

    El Bedewi, Ahmed; El Anany, Galal; El Mofty, Medhat; Kretlow, Ariane; Park, Simone; Miller, Lisa M

    2010-04-01

    The diagnosis of cutaneous lymphomas remains a challenge for both the clinician and dermatopathologist. To differentiate between frank malignant and premalignant lymphocytes within the skin. This study was performed on 20 patients with a mean age of 50 years. They were divided into two groups: mycosis fungoides (MF) (stage IA, IB and IIA) and pityriasis lichenoides chronica (PLC). Immunophenotyping using antibodies CD3, CD4, CD8, CD20 and CD30 was performed. Synchrotron Fourier transform infrared microspectroscopy (S-FTIRM) was performed on cell nuclei to assess chemical differences between MF and PLC cases as a potential complementary screening tool. Dermal spectra of both MF and PLC were compared using principal components analysis (PCA) of the S-FTIRM data. All PLC spectra was clustered together. However, the MF spectra formed two clusters, one that grouped with the PLC and the other grouped separately. Moreover, protein and nucleic acids showed highly significant differences between MF (IIA and IB), MF (IA) and PLC. The malignant transformation within lymphocytes was identifiable through the spectroscopic analysis of protein, RNA and DNA with S-FTIRM, making it a promising tool for classifying the progression of cutaneous T-cell lymphoma.

  19. Applicability of Proposed Diagnostic Criteria of Pityriasis Rosea: Results of a Prospective Case-Control Study in India

    Science.gov (United States)

    Zawar, Vijay; Chuh, Antonio

    2013-01-01

    Background: The diagnosis of pityriasis rosea (PR) is generally clinical. Previous studies usually recruited relatively small numbers of patients and control subjects, leading to low power of study results. Systematic reviews and meta-analyses cannot be readily performed, as the inclusion and exclusion criteria of these studies were not uniform. We have previously validated a set of diagnostic criteria (DC) in Chinese patients with PR. Aim: Our aim is to evaluate the validity and applicability of the DC of PR in Indian patients with PR. Study Design: Prospective unblinded pair-matched case-control study. Materials and Methods: The setting is a dermatology clinic in India served by one board-certified dermatologist. We recruited all 88 patients seen by us during five years diagnosed to have PR to join our study. For each study subject, we recruited the next patient who consulted us with differential diagnoses of PR as control subjects. We applied the DC of PR on all study and control subjects. Result: The sensitivity, specificity, positive predictive value, and negative predictive value of the DC were all 100%. Two-tailed Fisher's exact probability test result was 0.036. Φ was 1.00. Conclusion: The set of DC can be validly applied to Indian patients with PR. PMID:24249894

  20. An analysis of the Malassezia species distribution in the skin of patients with pityriasis versicolor in Chengdu, China.

    Science.gov (United States)

    Xie, Zhen; Ran, Yuping; Zhang, Hao; Zhang, Min; Wan, Huiying; Li, Conghui

    2014-01-01

    Pityriasis versicolor (PV) is a common clinical problem associated with Malassezia species (Malassezia spp.). Controversies remain regarding the specific species involved in the development of PV. This study analyzed the difference in Malassezia spp. distribution in lesional and nonlesional skin in Chinese PV patients. A paired design was applied. Lesional and nonlesional scales from 24 cases were collected; real-time fluorescence quantitative PCR was used to detect 10 different Malassezia spp. In lesional skin, the highest detection rates were for M. globosa (95.8%), M. restricta (91.7%), and M. sympodialis (50.0%). In nonlesional skin, the highest detection rates were for M. globosa (87.5%), M. restricta (79.2%), and M. dermatis (33.3%). A significant difference in the detection rate was only found for M. sympodialis (50.8% versus 20.8%, P = 0.04). Compared with nonlesional skin, the amount of M. globosa, M. restricta, and M. sympodialis in lesional skin was significantly higher (3.8 ± 1.3,  2.5 ± 1.1, and 3.2 ± 1.6 times higher, resp.). The results of this study do not indicate that M. globosa and M. restricta are directly correlated with PV development; however, M. sympodialis is more likely related to PV development in Chinese individuals.

  1. Flutrimazole shampoo 1% versus ketoconazole shampoo 2% in the treatment of pityriasis versicolor. A randomised double-blind comparative trial.

    Science.gov (United States)

    Rigopoulos, D; Gregoriou, S; Kontochristopoulos, G; Ifantides, A; Katsambas, A

    2007-05-01

    Flutrimazole is an imidazole derivative that has been proven to be efficient in superficial skin fungal infections. The aim of this randomised double-blind study was to compare for the first time, the efficiency and safety of flutrimazole 1% shampoo versus ketoconazole 2% shampoo in the treatment of tinea versicolor. Study population consisted of 60 patients with pityriasis versicolor diagnosed clinically and through direct microscopy and culture. Patients were randomly assigned to two groups: one instructed to apply flutrimazole shampoo 1% and one instructed to apply ketoconazole shampoo 2% both on head and body for 14 days. Patients were re-evaluated 14 days after the end of treatment clinically and through direct microscopy and culture. Twenty-one of 26 patients (80.8%) in the ketoconazole and 22 of 29 patients (75.9%) in the flutrimazole group had both visual healing and negative mycological evaluation. Comparison of the response between the two groups with the Yates' corrected chi-square was found statistically not significant (chi(2) = 0.19, d.f. = 1, P = 0.91). None of the patients in the two groups reported any adverse effects. Fourteen (53%) patients in the ketoconazole group and 23 (79%) in the flutrimazole group assessed the shampoos as cosmetically acceptable regarding texture, smell and foam properties. Flutrimazole shampoo 1% appears to present efficacy comparable with ketoconazole 2% in the treatment of tinea versicolor.

  2. Clinical analysis of 23 cases of pityriasis lichenoides%3例苔藓样糠疹的临床分析

    Institute of Scientific and Technical Information of China (English)

    冯素英; 靳培英

    2011-01-01

    目的 分析23例苔藓样糠疹(pityriasis lichenoides PL)患者的临床特点和治疗方案.方法 回顾性分析23例苔藓样糠疹患者的临床资料.结果 苔藓样糠疹患者以男性发病多(男:女=16:7),男性患者在急性痘疮样糠疹(pityriasis lichenoides et vsrioliformis acuta,PLEVA)中更占优势(7:2).10-20岁为其高发年龄段,PLEVA的发病年龄均在21岁以下,年龄的分布更集中.34.78%患者有上呼吸道感染史,慢性苔藓样糠疹(pityriasis lichenoides chronica,PLC)患者的病程较PLEVA的平均病程长.根据发病中的感染学说与药物本身具有抗炎作用,治疗的主要药物是口服红霉素或者四环素联合烟酰胺,病情严重者加用雷公藤多苷片.结论 苔藓样糠疹是一个可以控制的疾病,用药可以缩短病程.

  3. New ribosome-inactivating proteins with polynucleotide:adenosine glycosidase and antiviral activities from Basella rubra L. and bougainvillea spectabilis Willd.

    Science.gov (United States)

    Bolognesi, A; Polito, L; Olivieri, F; Valbonesi, P; Barbieri, L; Battelli, M G; Carusi, M V; Benvenuto, E; Del Vecchio Blanco, F; Di Maro, A; Parente, A; Di Loreto, M; Stirpe, F

    1997-12-01

    New single-chain (type 1) ribosome-inactivating proteins (RIPs) were isolated from the seeds of Basella rubra L. (two proteins) and from the leaves of Bougainvillea spectabilis Willd. (one protein). These RIPs inhibit protein synthesis both in a cell-free system, with an IC50 (concentration causing 50% inhibition) in the 10(-10) M range, and by various cell lines, with IC50S in the 10(-8)-10(-6) M range. All three RIPs released adenine not only from rat liver ribosomes but also from Escherichia coli rRNA, polyadenylic acid, herring sperm DNA, and artichoke mottled crinkle virus (AMCV) genomic RNA, thus being polynucleotide:adenosine glycosidases. The proteins from Basella rubra had toxicity to mice similar to that of most type 1 RIPs (Barbieri et al., 1993, Biochim Biophys Acta 1154: 237-282) with an LD50 (concentration that is 50% lethal) Bougainvillea spectabilis had an LD50 > 32 mg.kg-1. The N-terminal sequence of the two RIPs from Basella rubra had 80-93% identity, whereas it differed from the sequence of the RIP from Bougainvillea spectabilis. When tested with antibodies against various RIPs, the RIPs from Basella gave some cross-reactivity with sera against dianthin 32, and weak cross-reactivity with momordin I and momorcochin-S, whilst the RIP from Bougainvillea did not cross-react with any antiserum tested. An RIP from Basella rubra and one from Bougainvillea spectabilis were tested for antiviral activity, and both inhibited infection of Nicotiana benthamiana by AMCV.

  4. Comparative efficacy of topical application of tacrolimus and clotrimazole in the treatment of pityriasis versicolor: A single blind, randomised clinical trial.

    Science.gov (United States)

    Sepaskhah, Mozhdeh; Sadat, Maryam Sadat; Pakshir, Keyvan; Bagheri, Zahra

    2017-05-01

    Pityriasis versicolor (PV) is a common superficial fungal disease. Possibility of emergence of resistant strains to azoles, and difficulty in differentiation of hypopigmented PV and early vitiligo, encouraged us to evaluate the efficacy of topical tacrolimus (a calcineurin inhibitor agent with proven in vitro anti-Malassezia effect) for PV treatment generally and its effect on PV-induced hypopigmentation specifically. To evaluate the efficacy of topical tacrolimus on pityriasis versicolor. Fifty PV patients were randomly allocated into two equal groups applying either topical clotrimazol or tacrolimus twice daily for 3 weeks. They were evaluated at the beginning of study, in the third and fifth weeks clinically and mycologically (direct smear). Although both treatments resulted in global, clinical, and mycological cure of PV, there was no significant difference regarding the mentioned aspects of cure between tacrolimus and clotrimazole treated patients. (P-value: .63, .45, and .26, respectively) Tacrolimus had no significant effect on hypopigmentation in the fifth week follow-up. (P-value: .62). In spite of the lack of efficacy of tacrolimus on PV-induced hypopigmentation, the therapeutic effect on PV introduces tacrolimus as a therapeutic option for PV, especially when early vitiligo is among the differential diagnoses without concerning the aggravating effect of topical corticosteroids on PV. © 2017 Blackwell Verlag GmbH.

  5. Wong-Type Dermatomyositis Showing Porokeratosis-Like Changes (Columnar Dyskeratosis: A Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Nicole Umanoff

    2015-01-01

    Full Text Available Background: Wong-type dermatomyositis (DM exhibits simultaneous pityriasis rubra pilaris (PRP features. Case Report: A 50-year-old woman presented with a heliotrope rash, Gottron's papules, and a poikilodermic, erythematous rash in shawl distribution without evidence of muscle weakness. Despite topical corticosteroids, the eruption progressed 9 months later to include generalized hyperkeratotic follicular papules, islands of sparing, and atrophic macules with a collarette of scale suggestive of porokeratosis. Mild dysphonia was the only sign of muscle weakness. Serology showed positive ANA. Histopathology revealed interface dermatitis with dermal mucin and melanophages, irregular psoriasiform hyperplasia, alternating mounds of para- and orthokeratosis, and tiers of dyskeratotic cells (columnar dyskeratosis. Systemic corticosteroid therapy was not tolerated; acitretin diminished the hyperkeratosis. While hyperpigmentation persisted, no progression of cutaneous or muscular symptoms has occurred after 22 months of follow-up and cessation of the therapy. Overall, her course did not differ from the natural history documented in the literature review of Wong-type DM. The most similar case also exhibited pseudocornoid lamella changes. Conclusion: Wong-type DM is a clinicopathologic DM-PRP hybrid that can also exhibit porokeratosis-like features best described as columnar dyskeratosis. Recognizing these types of lesions in DM is warranted in order to make an accurate assessment of their prognostic significance.

  6. Erytrodermia łuszczycowa po ogólnym zastosowaniu kortykosteroidów – opis przypadku

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    Joanna Maj

    2011-11-01

    Full Text Available Introduction. Erythroderma (exfoliative dermatitis is an acute, generalizedinflammation of the skin, which affects at least 90% of its surface.It is a life threatening illness in the course of which various types anddegrees of scaling and itching are observed. The main causes of erythrodermaare psoriasis, atopic dermatitis, drug reactions, mycosis fungoidesand pityriasis rubra pilaris. Psoriatic erythroderma is classified as a secondary erythroderma. It may develop spontaneously or moreoften as a result of incorrect treatment.Objective. To present side effects of oral corticosteroids administrationin a patient with psoriasis.Case report. A 36-year-old woman, suffering from psoriasis for over7 years, was admitted to the hospital inMarch 2011 due to exacerbationof skin lesions up to erythroderma after administration of oral corticosteroidtherapy. Three weeks after corticosteroids withdrawal, significantworsening of the disease was observed. On admission she presentedmassiveskin inflammation, scaling and itching. Laboratory testsrevealed increased markers of inflammation. The patient was treatedwith combined immunosuppressive therapy and topical ointments.After 3 weeks, significant regression of skin lesions and normalizationof laboratory tests were observed.Conclusions. Psoriasis is a common cause of erythroderma in adults.Although in Europe the disease affects about 2% of the population andknowledge of its treatment should be common, cases of systemicadministration of corticosteroids in patients with psoriasis in the treatmentof the underlying disease or of the comorbidities are still beingreported.

  7. Significance of clinicopathological correlation in psoriasis

    Directory of Open Access Journals (Sweden)

    Gopal Ambadasrao Pandit

    2015-01-01

    Full Text Available Context: Psoriasis affects about 1.5% to 3% of world′s population. Other papulosquamous dermatoses are Pityriasis rosea, Lichen planus, Seborrheic dermatitis, Pityriasis rubra pilaris and Parapsoriasis. Drug eruptions, tinea corporis, and secondary syphilis may also have papulosquamous morphology. Because all papulosquamous disorders are characterized by scaling papules, clinical confusion may result during their diagnosis. Separation of each of these becomes important because the treatment and prognosis for each tends to be disease-specific. Aim: To study the pattern of clinical and histopathological features of psoriasis of the skin with clinicopathological correlation. Material and methods: The present study of 42 cases of psoriasis of the skin was carried out in the Department of Pathology of a tertiary care centre from December 2009 to October 2011. In this study, the patients which were clinically diagnosed as psoriasis of skin, before starting the treatment and attending the outdoor skin department were selected. Histopathological findings were interpreted in light of clinical details. Results: Out of 42 cases of psoriasis 24 (57.14% were males, 18 (42.86% were females with male to female ratio of 1.33:1. Mean age was 34.45 years. Maximum number of cases 22 (52.38% were encountered in 3rd and 4th decade of life. Histopathological findings: parakeratosis, acanthosis, suprapapillary thinning, Munro microabscesses and hypogranulosis were noted in most of the cases. Conclusion: Histopathology serves as a diagnostic tool and rules out other lesions which mimic psoriasis. The most accurate diagnosis is the one that most closely correlates with clinical outcome and helps to direct the most appropriate clinical intervention.

  8. Protective effects of pretreatment with Radix Paeoniae Rubra on acute lung injury induced by intestinal ischemia/ reperfusion in rats

    Institute of Scientific and Technical Information of China (English)

    CHEN Chang; ZHANG Fan; XIA Zhong-yuan; LIN Hui; MO An-sheng

    2008-01-01

    Objective: To investigate the effect of pretreatment with Radix Paeoniae Rubra (RPR) on acute lung injury induced by intestinal ischemia/reperfusion in rats and its protective mechanism.Methods:n lung tissues was detected by immunohistochemistry and morphometry computer image analysis. Arterial blood gas analysis, lung permeability index, malondialdehyde (MDA) and superoxide dismutase (SOD) contents in lungs were measured. The histological changes of lung tissue were observed under light microscope.Results:The expression of HO-1 in RPR-pretreatment group and hemin group was obviously higher than that in sham-operation group and I/R group (P < 0.01). The level of MDA and lung permeability index in RPR-pretreatment and hemin group were significantly lower than those in I/R group (P<0.01 or P<0.05), while the activity of SOD in RPR-pretreatment and hemin group was obviously higher than that in I/R group (P<0.01 ). Under light microscope, the pathologic changes induced by I/R were significantly attenuated by RPR.Conclusion : Intestinal ischemia/reperfusion may result in acute lung injury and pretreatment with RPR injection can attenuate the injury. The protective effect of RPR on the acute lung injury is related to its property of inducing HO-1 expression and inhibiting lipid peroxidation.

  9. Purification of a lectin from M. rubra leaves using immobilized metal ion affinity chromatography and its characterization.

    Science.gov (United States)

    Sureshkumar, Thavamani; Priya, Sulochana

    2012-12-01

    Lectins represent a heterogeneous group of proteins/glycoproteins with unique carbohydrate specificity, with wide range of biomedical applications. The multi-step purification protocols generally used for purification of lectin result in a significant reduction in the final yield and activity. In the present study, Morus rubra lectin (MRL) was purified to homogeneity from the leaves using a single-step immobilized metal ion affinity chromatography (IMAC) procedure. The approximate molecular weight of purified MRL resolved as a single band on SDS-PAGE was 52 kDa. Final percentage yield of purified lectin by IMAC was calculated as 74.7 %. Purified MRL was specific to three sugars, galactose, D-galactosamine and N-acetyl-D-galactosamine, and rendered haemagglutination (HA) activity towards different human blood group RBCs. MRL showed stability over a wide range of temperature (up to 80 °C) and pH (4-11). Chelation of the lectin with EDTA did not alter HA which indicates that metal ion is not required for activity. In the presence of Fe(2+), Ca(2+), Zn(2+), Ni(2+), Mn(2+), Na(+) and K(+), HA activity was reduced to 50 %, whereas the presence of trivalent metal ions (Fe3(+) and Al(3+)) and Cu(2+) did not affect the activity. In the presence of Mg(2+) and Hg(2+), only 25 % of HA activity remained.

  10. Nocardia rubra cell-wall skeleton promotes CD4(+) T cell activation and drives Th1 immune response.

    Science.gov (United States)

    Wang, Guangchuan; Wu, Jie; Miao, Miao; Dou, Heng; Nan, Ning; Shi, Mingsheng; Yu, Guang; Shan, Fengping

    2017-03-15

    Several lines of evidences have shown that Nocardia rubra cell wall skeleton (Nr-CWS) has immunoregulatory and anti-tumor activities. However, there is no information about the effect of Nr-CWS on CD4(+) T cells. The aim of this study was to explore the effect of Nr-CWS on the phenotype and function of CD4(+) T cells. Our results of in vitro experiments showed that Nr-CWS could significantly up-regulate the expression of CD69 and CD25 on CD4(+) T cells, promote the proliferation of CD4(+) T cells, increase the production of IFN-γ, TNF-α and IL-2 in the supernatants, but has no significant effect on the apoptosis and death of CD4(+) T cells. Results of in vivo experiments showed that Nr-CWS could promote the proliferation of CD4(+) T cells, and increase the production of IL-2, IFN-γ and TNF-α (Th1 type cytokines). These data suggest that Nr-CWS can enhance the activation of CD4(+) T cells, promote the proliferation of CD4(+) T cells and the differentiation of CD4(+) T cells to Th1 cells.

  11. Characterization of major betalain pigments -gomphrenin, betanin and isobetanin from Basella rubra L. fruit and evaluation of efficacy as a natural colourant in product (ice cream) development.

    Science.gov (United States)

    Kumar, S Sravan; Manoj, P; Shetty, N P; Prakash, Maya; Giridhar, P

    2015-08-01

    Basella rubra L. (Basellaceae) commonly known as Malabar spinach is a leafy vegetable which accumulates pigments in its fruits. To find out the feasibility of utilizing pigment rich extracts of its fruit as natural food colourant, fruits at different stages were analysed for pigment profiling, carbohydrate content, physical dimensions and weight. Total betalains content increased rapidly from early (green) through intermediate (half-done red-violet) to matured stage (red-violet). Maximum pigment content was observed in ripened fruits (143.76 mg/100 g fresh weight). The major betalain pigment characterized was gomphrenin I in ripened fruits (26.06 mg), followed by intermediate fruits (2.15 mg) and least in early fruits (0.23 mg) in 100 g of fresh deseeded fruits. Total carbohydrates content and the chroma values (redness) were also increased during ontogeny of B. rubra fruits. The textural characters of developing fruits showed the smoothness of green fruits with lower rupture force (0.16 N/s) than ripe ones (0.38 N/s). The pigment-rich fruit extract was used as natural colourant in ice-cream, to evaluate its effect on physicochemical properties and acceptability of the product. After six months of storage at -20 °C, 86.63 % colour was retained in ice-cream. The ice-cream had good overall sensorial quality and was liked by consumers indicating that addition of B. rubra fruit extract did not alter the sensory quality of the product. The colour values also indicate that there was no significant decrease of this pigment-rich extracts of fruits for its incorporation in food products.

  12. Alteration of foliar flavonoid chemistry induced by enhanced UV-B radiation in field-grown Pinus ponderosa, Quercus rubra and Pseudotsuga menziesii.

    Science.gov (United States)

    Warren, Jeffrey M; Bassman, John H; Mattinson, D Scott; Fellman, John K; Edwards, Gerald E; Robberecht, Ronald

    2002-03-01

    Chromatographic analyses of foliage from several tree species illustrate the species-specific effects of UV-B radiation on both quantity and composition of foliar flavonoids. Pinus ponderosa, Quercus rubra and Pseudotsuga menziesii were field-grown under modulated ambient (1x) and enhanced (2x) biologically effective UV-B radiation. Foliage was harvested seasonally over a 3-year period, extracted, purified and the flavonoid fraction applied to a mu Bondapak/C(18) column HPLC system sampling at 254 nm. Total flavonoid concentrations in Quercus rubra foliage were more than twice (leaf area basis) that of the other species; Pseudotsuga menziesii foliage had intermediate levels and P. ponderosa had the lowest concentrations of total flavonoids. No statistically significant UV-B radiation-induced effects were found in total foliar flavonoid concentrations for any species; however, concentrations of specific compounds within each species exhibited significant treatment effects. Higher (but statistically insignificant) levels of flavonoids were induced by UV-B irradiation in 1- and 2-year-old P. ponderosa foliage. Total flavonoid concentrations in 2-year-old needles increased by 50% (1x ambient UV-B radiation) or 70% (2x ambient UV-B radiation) from that of 1-year-old tissue. Foliar flavonoids of Q. rubra under enhanced UV-B radiation tended to shift from early-eluting compounds to less polar flavonoids eluting later. There were no clear patterns of UV-B radiation effects on 1-year-old P. menziesii foliage. However, 2-year-old tissue had slightly higher foliar flavonoids under the 2x UV-B radiation treatment compared to ambient levels. Results suggest that enhanced UV-B radiation will alter foliar flavonoid composition and concentrations in forest tree species, which could impact tissue protection, and ultimately, competition, herbivory or litter decomposition.

  13. Characterizing Ipomopsis rubra (Polemoniaceae) germination under various thermal scenarios with non-parametric and semi-parametric statistical methods.

    Science.gov (United States)

    Pérez, Hector E; Kettner, Keith

    2013-10-01

    Time-to-event analysis represents a collection of relatively new, flexible, and robust statistical techniques for investigating the incidence and timing of transitions from one discrete condition to another. Plant biology is replete with examples of such transitions occurring from the cellular to population levels. However, application of these statistical methods has been rare in botanical research. Here, we demonstrate the use of non- and semi-parametric time-to-event and categorical data analyses to address questions regarding seed to seedling transitions of Ipomopsis rubra propagules exposed to various doses of constant or simulated seasonal diel temperatures. Seeds were capable of germinating rapidly to >90 % at 15-25 or 22/11-29/19 °C. Optimum temperatures for germination occurred at 25 or 29/19 °C. Germination was inhibited and seed viability decreased at temperatures ≥30 or 33/24 °C. Kaplan-Meier estimates of survivor functions indicated highly significant differences in temporal germination patterns for seeds exposed to fluctuating or constant temperatures. Extended Cox regression models specified an inverse relationship between temperature and the hazard of germination. Moreover, temperature and the temperature × day interaction had significant effects on germination response. Comparisons to reference temperatures and linear contrasts suggest that summer temperatures (33/24 °C) play a significant role in differential germination responses. Similarly, simple and complex comparisons revealed that the effects of elevated temperatures predominate in terms of components of seed viability. In summary, the application of non- and semi-parametric analyses provides appropriate, powerful data analysis procedures to address various topics in seed biology and more widespread use is encouraged.

  14. "Dose-effect-response" Relationships of Paeoniae Radix Rubra on α-Naphthylisothiocyanate-induced Acute Cholestatic Hepatitis in Rats

    Institute of Scientific and Technical Information of China (English)

    WEI Si-si; ZHAO Yan-ling; JIANG Feng-juan; JIA Lei; ZHU Yun; WANG Jia-bo; SUN Zhi-yong; LI Rui-sheng; XIAO Xiao-he

    2011-01-01

    Objective To investigate the hepatoprotective effects of Paeoniae Radix Rubra (PRR) at different doses against α-naphthylisothiocyanate (α-NIT)-induced acute cholestatic hepatitis in rats.Methods Rats were ig administrated with vehicle or PRR [(1,9,18,36,54,72,and 81 g/(kg·d)] 3 d before and 2 d after α-NIT (60 mg/kg) ig administration.The general status of rats,histopathology of liver,serum alanine aminotransaminase,aspartate aminotransaminase,total bilirubin,direct bilirubin,and alkaline phosphatase levels,were observed at respective time points (24 and 48 h) after α-NIT administration.Using cluster analysis and correspondence analysis,the "dose-effect-response" relationships of PRR were evaluated.Results The results showed that compared with model group,the serum biochemistry index significantly decreased with the increasing of PRR dosage (P < 0.01),and the change and necrosis of hepatic cellula,and inflammatory cell infiltration were gradually alleviated.However,the improvement was not obviously found in the low-dose group [1 g/(kg·d)].The cluster analysis and correspondence analysis results showed that different doses of PRR could significantly ameliorate α-NIT-induced acute cholestatic hepatitis of rats in a dose-dependent manner.Conclusion The experiments show that administration doses of PRR in clinical use should be added properly in order to gain the expectant therapeutic effect,especially in the treatment of heavy acute cholestasis hepatitis.

  15. Phytochemical Characterization of Chinese Bayberry (Myrica rubra Sieb. et Zucc. of 17 Cultivars and Their Antioxidant Properties

    Directory of Open Access Journals (Sweden)

    Xianan Zhang

    2015-06-01

    Full Text Available In order to fully understand the variations of fruit quality-related phytochemical composition in Chinese bayberry (Myrica rubra Sieb. et Zucc., mature fruit of 17 cultivars from Zhejiang and Jiangsu provinces was used for the investigation of fruit quality attributes, including fruit color, soluble sugars, organic acids, total phenolics, flavonoids, antioxidant capacity, etc. Sucrose was the main soluble sugar, while citric acid was the main organic acid in bayberry fruit. The content of total phenolics and total flavonoids were positively correlated with 2,2-diphenyl-1-picrylhydrazyl (DPPH, ferric reducing antioxidant power (FRAP antioxidant activity and 2,2ʹ-azino-bis(3-ethylbenzothiazoline- 6-sulphonic acid (ABTS radical scavenging activity. Five anthocyanidins, i.e., delphinidin–hexoside (Dp–Hex, cyanidin-3–O-galactoside (C-3–Gal, cyanidin-3–O-glucoside (C-3–Glu, pelargonidin-3–O-glucoside (Pg-3–Glu and peonidin-3-O-glucoside (Pn-3–Glu, and seven flavonols compounds, i.e., myricetin-3-O-rhamnoside (M-3–Rha, myricetin deoxyhexoside–gallate (M-DH–G, quercetin-3-O-galactoside (Q-3–Gal, quercetin-3– O-glucoside (Q-3–Glu, quercetin-3–O-rhamnoside (Q-3–Rha, kaempferol-3–O-galactoside (K-3–Gal and kaempferol-3–O-glucoside (K-3–Glu, were identified and characterized among the cultivars. The significant differences in phytochemical compositions among cultivars reflect the diversity in bayberry germplasm, and cultivars of good flavor and/or rich in various health-promoting phytochemicals are good candidates for future genetic breeding of bayberry fruit of high quality. In conclusion, our results may provide important information for further breeding or industrial utilization of different bayberry resources.

  16. Phytochemical Characterization of Chinese Bayberry (Myrica rubra Sieb. et Zucc.) of 17 Cultivars and Their Antioxidant Properties.

    Science.gov (United States)

    Zhang, Xianan; Huang, Huizhong; Zhang, Qiaoli; Fan, Fangjuan; Xu, Changjie; Sun, Chongde; Li, Xian; Chen, Kunsong

    2015-06-02

    In order to fully understand the variations of fruit quality-related phytochemical composition in Chinese bayberry (Myrica rubra Sieb. et Zucc.), mature fruit of 17 cultivars from Zhejiang and Jiangsu provinces was used for the investigation of fruit quality attributes, including fruit color, soluble sugars, organic acids, total phenolics, flavonoids, antioxidant capacity, etc. Sucrose was the main soluble sugar, while citric acid was the main organic acid in bayberry fruit. The content of total phenolics and total flavonoids were positively correlated with 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP) antioxidant activity and 2,2'-azino-bis(3-ethylbenzothiazoline- 6-sulphonic acid) (ABTS) radical scavenging activity. Five anthocyanidins, i.e., delphinidin-hexoside (Dp-Hex), cyanidin-3-O-galactoside (C-3-Gal), cyanidin-3-O-glucoside (C-3-Glu), pelargonidin-3-O-glucoside (Pg-3-Glu) and peonidin-3-O-glucoside (Pn-3-Glu), and seven flavonols compounds, i.e., myricetin-3-O-rhamnoside (M-3-Rha), myricetin deoxyhexoside-gallate (M-DH-G), quercetin-3-O-galactoside (Q-3-Gal), quercetin-3- O-glucoside (Q-3-Glu), quercetin-3-O-rhamnoside (Q-3-Rha), kaempferol-3-O-galactoside (K-3-Gal) and kaempferol-3-O-glucoside (K-3-Glu), were identified and characterized among the cultivars. The significant differences in phytochemical compositions among cultivars reflect the diversity in bayberry germplasm, and cultivars of good flavor and/or rich in various health-promoting phytochemicals are good candidates for future genetic breeding of bayberry fruit of high quality. In conclusion, our results may provide important information for further breeding or industrial utilization of different bayberry resources.

  17. Protective effect of flavonoid extract from Chinese bayberry (Myrica rubra Sieb. et Zucc.) fruit on alcoholic liver oxidative injury in mice.

    Science.gov (United States)

    Liu, Hesheng; Qi, Xiangyang; Cao, Shaoqian; Li, Peipei

    2014-07-01

    To evaluate the beneficial effects of Chinese bayberry (Myrica rubra Sieb. et Zucc.) flavonoid extract (CBFE) on chronic alcohol-induced liver oxidative injury in mice, experimental mice were pretreated with different doses of CBFE (50-200 mg/kg) for 4 weeks by gavage feeding. Biochemical markers and enzymatic antioxidants from serum, liver tissue, mitochondria and microsomes were examined. Our results showed that the activities of TC, TG, L-DLC in serum, the activity of CYP2E1 in microsomes, and the levels of MDA in liver tissue and mitochondria, decreased significantly (P injury may be due to its potent antioxidant properties.

  18. Pitiríase versicolor circinada: isolamento de Malassezia sympodialis - Relato de caso Pityriasis versicolor circinata: isolation of Malassezia sympodialis - Case report

    Directory of Open Access Journals (Sweden)

    Valéria Maria de Souza Framil

    2010-04-01

    Full Text Available Os autores descrevem caso de pitiríase versicolor circinada, cujo agente etiológico isolado foi Malassezia sympodialis em uma mulher de 34 anos. O isolamento e identificação da Malassezia sympodialis foi em ágar Dixon modificado e o método molecular para confirmação da espécie foi PCR-RFLP (polymerase chain reaction and restriction fragment length polymorphism analysis.The authors report a case of pityriasis versicolor circinata whose isolated etiologic agent was Malassezia sympodialis in a 34-year-old woman. The isolation and identification of Malassezia sympodialis were accomplished with modified Dixon's agar, and the molecular method used to confirm the species was polymerase chain reaction and restriction fragment length polymorphism analysis (PCR-RFLP.

  19. A novel contrast stain for the rapid diagnosis of pityriasis versicolor: A comparison of Chicago Sky Blue 6B stain, potassium hydroxide mount and culture

    Directory of Open Access Journals (Sweden)

    Nikita Lodha

    2015-01-01

    Full Text Available Background: The mycological study of pityriasis versicolor is usually done by potassium hydroxide (KOH mount and culture. However, KOH mount lacks a color contrast and requires a trained eye to interpret, while culture is difficult to perform, time consuming and has low sensitivity. Chicago Sky Blue 6B (CSB is a new contrast stain that highlights the fungal hyphae and spores, blue against a purplish background. Aims and Objectives: This study was done to compare the utility of a novel contrast stain (CSB stain with KOH mount and culture. Materials and Methods: Skin scrapings from the lesions of 100 clinically diagnosed cases of P. versicolor were subjected to (1 KOH mount and CSB stain for direct microscopic examination and (2 culture using Sabouraud′s dextrose agar. The statistical analysis of CSB stain and culture was done using KOH mount as the reference method, as it is the most commonly performed and practical diagnostic test available for P. versicolor. An interrater reliability analysis using the Cohen′s Kappa statistic was performed to determine consistency (agreement among the different modalities. Observations and Results: Direct microscopy with CSB stain, KOH mount and mycological culture showed positive results in 98 (98%, 92 (92% and 56 (56% patients, respectively. Using KOH mount as the reference method, CSB stain had a sensitivity of 100% which was significantly higher than culture (60.9%. Statistically significant fair agreement was found between CSB stain and KOH mount (94% with κ=0.38, P < 0.001. Negligible agreement was found between CSB stain and culture (66%, κ=0.199, P = 0.001 as well as between KOH mount and culture (64%, κ=0.051, P = 0.107. Conclusion: CSB staining of skin scrapings is the most sensitive method for the diagnosis of pityriasis versicolor. Due to the distinct contrast provided by CSB, it is easy to perform, rapid and qualitatively superior to KOH mount.

  20. A Novel Contrast Stain for the Rapid Diagnosis of Pityriasis Versicolor: A Comparison of Chicago Sky Blue 6B Stain, Potassium Hydroxide Mount and Culture

    Science.gov (United States)

    Lodha, Nikita; Poojary, Shital Amin

    2015-01-01

    Background: The mycological study of pityriasis versicolor is usually done by potassium hydroxide (KOH) mount and culture. However, KOH mount lacks a color contrast and requires a trained eye to interpret, while culture is difficult to perform, time consuming and has low sensitivity. Chicago Sky Blue 6B (CSB) is a new contrast stain that highlights the fungal hyphae and spores, blue against a purplish background. Aims and Objectives: This study was done to compare the utility of a novel contrast stain (CSB stain) with KOH mount and culture. Materials and Methods: Skin scrapings from the lesions of 100 clinically diagnosed cases of P. versicolor were subjected to (1) KOH mount and CSB stain for direct microscopic examination and (2) culture using Sabouraud's dextrose agar. The statistical analysis of CSB stain and culture was done using KOH mount as the reference method, as it is the most commonly performed and practical diagnostic test available for P. versicolor. An interrater reliability analysis using the Cohen's Kappa statistic was performed to determine consistency (agreement) among the different modalities. Observations and Results: Direct microscopy with CSB stain, KOH mount and mycological culture showed positive results in 98 (98%), 92 (92%) and 56 (56%) patients, respectively. Using KOH mount as the reference method, CSB stain had a sensitivity of 100% which was significantly higher than culture (60.9%). Statistically significant fair agreement was found between CSB stain and KOH mount (94% with κ=0.38, P skin scrapings is the most sensitive method for the diagnosis of pityriasis versicolor. Due to the distinct contrast provided by CSB, it is easy to perform, rapid and qualitatively superior to KOH mount. PMID:26288400

  1. 发根农杆菌介导的杨梅遗传转化研究初报%Genetic transformation of Myrica rubra mediated by Agrobacterium rhizogenes

    Institute of Scientific and Technical Information of China (English)

    何新华; 陈力耕; 郭长禄

    2007-01-01

    为了建立发根农杆菌Agrobacterium rhizogenes介导的杨梅Myrica rubra遗传转化体系,利用携带拟南芥Arabidopsis thaliana LEAFY cDNA片段的发根农杆菌R15834感染东魁杨梅M.rubra'Dongkui'和荸荠杨梅M.rubra 'Boji'的子叶、叶片和茎段.结果表明,只从东魁杨梅子叶上诱导出毛状根,而且产生毛状根的东魁杨梅子叶数在10%以下.杨梅子叶产生毛状根受多种因素影响,新种子比旧种子容易产生毛状根,在1/2 MS(Murashige and Skoog)培养基培养较在MS培养基上培养好.东魁杨梅子叶上的毛状根经聚合酶链反应(polymerase chain reaction,PCR)检测和Southern杂交检测,证实已将拟南芥的LEAFY cDNA片段成功导入并整合到东魁杨梅子叶中.图2参10

  2. Beta-carotene-rich carotenoid-protein preparation and exopolysaccharide production by Rhodotorula rubra GED8 grown with a yogurt starter culture.

    Science.gov (United States)

    Frengova, Ginka I; Simova, Emilina D; Beshkova, Dora M

    2006-01-01

    The underlying method for obtaining a beta-carotene-rich carotenoid-protein preparation and exopolysaccharides is the associated cultivation of the carotenoid-synthesizing lactose-negative yeast strain Rhodotorula rubra GED8 with the yogurt starter culture (Lactobacillus bulgaricus 2-11 + Streptococcus thermophilus 15HA) in whey ultrafiltrate (45 g lactose/l) with a maximum carotenoid yield of 13.37 mg/l culture fluid on the 4.5th day. The chemical composition of the carotenoid-protein preparation has been identified. The respective carotenoid and protein content is 497.4 microg/g dry cells and 50.3% per dry weight, respectively. An important characteristic of the carotenoid composition is the high percentage (51.1%) of beta-carotene (a carotenoid pigment with the highest provitamin A activity) as compared to 12.9% and 33.7%, respectively, for the other two individual pigments--torulene and torularhodin. Exopolysaccharides (12.8 g/l) synthesized by the yeast and lactic acid cultures, identified as acid biopolymers containing 7.2% glucuronic acid, were isolated in the cell-free supernatant. Mannose, produced exclusively by the yeast, predominated in the neutral carbohydrate biopolymer component (76%). The mixed cultivation of R. rubra GED8 with the yogurt starter (L. bulgaricus 2-11 + S. thermophilus 15HA) in ultrafiltrate under conditions of intracellular production of maximum amount of carotenoids and exopolysaccharides synthesis enables combined utilization of the culture fluid from the fermentation process.

  3. Therapeutic efficacy and safety of Paeoniae Radix Rubra formulae in relieving hyperbilirubinemia induced by viral hepatitis: A meta-analysis

    Directory of Open Access Journals (Sweden)

    Yinqiu eHuang

    2016-03-01

    Full Text Available Objective: Hyperbilirubinemia is one of the most devastating pathologies induced by various liver diseases. Formulae related to Paeoniae Radix Rubra (PRR at high doses have been applied to treat hyperbilirubinemia in traditional Chinese medicine. The aim of this systematic review and meta-analysis is to assess the efficacy and safety of formulae relevant to high-dose PRR in patients suffering from hyperbilirubinemia induced by viral hepatitis.Methods: We performed a meta-analysis of randomized-controlled clinical trials to evaluate the efficacy and safety of formulae that apply a high dose of PRR for hyperbilirubinemia. Seven databases were searched until April 2015. All studies were included according to detailed criteria and assessed for methodological quality. The outcome measurements were recorded for further analysis using the Revman 5.2.11 software. Results: Fifteen articles involving 1323 patients with hyperbilirubinemia were included. Formulae with high-dose PRR might promote the efficacy of either a combined application ([OR: 3.98, 95%CI (2.91, 5.43]; P<0.01 or a single application ([OR: 4.00, 95%CI (1.50, 10.68]; P<0.01 for hyperbilirubinemia. The indices of TBIL, ALT and AST significantly decreased ([MD: -75.57, 95%CI (-94.88, -56.26], [MD: -26.54, 95%CI (-36.19, -16.88] and ([MD: -28.94, 95%CI (-46.26, -11.61]; P<0.01, respectively. In addition, formulae with high-dose PRR could enhance the treatment efficacy of hyperbilirubinemia triggered by hepatitis B ([OR: 2.98, 95% CI (1.75, 5.05]; P<0.01. Furthermore, the efficacy was enhanced with an increasing dosage of PRR. Two articles reported that no side effects occurred in clinical trials, and 3 studies noted that patients presented light digestive tract symptoms.Conclusion: Formulae relevant to high-dose PRR ameliorate hyperbilirubinemia and might constitute a promising therapeutic approach. For widespread acceptance by practitioners, more rigorously designed multicenter, double

  4. Warming and drought differentially influence the production and resorption of elemental and metabolic nitrogen pools in Quercus rubra.

    Science.gov (United States)

    Suseela, Vidya; Tharayil, Nishanth; Xing, Baoshan; Dukes, Jeffrey S

    2015-11-01

    The process of nutrient retranslocation from plant leaves during senescence subsequently affects both plant growth and soil nutrient cycling; changes in either of these could potentially feed back to climate change. Although elemental nutrient resorption has been shown to respond modestly to temperature and precipitation, we know remarkably little about the influence of increasing intensities of drought and warming on the resorption of different classes of plant metabolites. We studied the effect of warming and altered precipitation on the production and resorption of metabolites in Quercus rubra. The combination of warming and drought produced a higher abundance of compounds that can help to mitigate climatic stress by functioning as osmoregulators and antioxidants, including important intermediaries of the tricarboxylic acid (TCA) cycle, amino acids including proline and citrulline, and polyamines such as putrescine. Resorption efficiencies (REs) of extractable metabolites surprisingly had opposite responses to drought and warming; drought treatments generally increased RE of metabolites compared to ambient and wet treatments, while warming decreased RE. However, RE of total N differed markedly from that of extractable metabolites such as amino acids; for instance, droughted plants resorbed a smaller fraction of elemental N from their leaves than plants exposed to the ambient control. In contrast, plants in drought treatment resorbed amino acids more efficiently (>90%) than those in ambient (65-77%) or wet (42-58%) treatments. Across the climate treatments, the RE of elemental N correlated negatively with tissue tannin concentration, indicating that polyphenols produced in leaves under climatic stress could interfere with N resorption. Thus, senesced leaves from drier conditions might have a lower nutritive value to soil heterotrophs during the initial stages of litter decomposition despite a higher elemental N content of these tissues. Our results suggest that N

  5. The content determination of radix paeoniae rubra in Lemai pill by HPLC%HPLC 测定乐脉丸中赤芍的含量

    Institute of Scientific and Technical Information of China (English)

    王从敏; 熊本立; 徐小利

    2014-01-01

    Objective To establish the determination method of radix paeoniae rubra in Lemai Pills by HPLC meth-od.Methods The column was Waters Symmetry RP18(5um,3.9X150mm);Acetonitrile-0.05% phosphoric acid(13:87)as mobile phase.Detection wavelength was 230nm.Results The injection volume of paeoniflorin ranged from 0.20403 to 2.04032(r=0.9999),within the scope,with each peak,has a good linear relationship.The average respectively were 101.5%and 100.3%.RSD respectively were 1.5% and 1.4% ( n=6).Conclusion The content determination of radix paeoniae rubra in Lemai pill by HPLC is handy ,fastly and accurately ,has high sensitivity and repeatability ,can be the determined meth-od of radix paeoniae rubra in Lemai pill .%目的:建立乐脉丸中赤芍含量的HPLC测定方法。方法采用色谱柱为Waters Symmetry Shield RP18(5μm,3.9mm ×150mm);流动相为乙腈-0.05%磷酸(13∶87);检测波长为230nm。结果芍药苷的进样量在0.20403~2.04032μg ( r =0.9999)范围内与各自峰面积积分值呈良好线性关系,平均回收率分别为101.5%和100.3%,RSD分别为1.5%和1.4%(n=6)。结论 HPLC测定乐脉丸中赤芍的含量方法简便、快速准确、灵敏度高,重复性好,可作为乐脉丸中赤芍的含量测定。

  6. The effect of water extracts from leaves of Festuca rubra, F. ovina and F. Arundinacea on the initial growth and development of other grass species

    Directory of Open Access Journals (Sweden)

    Halina Lipińska

    2013-07-01

    Full Text Available The allelopathic effect of plants is one of the least known factors determining the stability of lawn swards. Leaves are a rich source of allelopathic substances. Washed out by rain or dew drops, or released during biomass decomposition, these substances can impact plants. In practice, cut sward is often left on the lawn surface and can have an allelopathic effect on regrowing plants. The effect of released allelochemicals depends on many factors, including their concentration. Hence, in order to maintain the high functional properties of the lawn, information is needed on the critical concentrations of allelochemicals inhibiting plant growth and development. Laboratory research was thus undertaken (on Petri dishes to evaluate the effect of various water extracts of leaves of selected lawn grass cultivars. The following cultivars were the donors: 'Areta', 'Nimba', 'Olivia' (Festuca rubra; 'Espro', 'Pintor' (F. ovina,and 'Asterix' (F. arundinacea, while the acceptors were: 'Niwa' (Agrostis capillaris, 'Asterix' (Festuca arundinacea, 'Espro' (F. ovina, 'Areta' (F. rubra, 'Stadion' (Lolium perenne, and 'Bila' (Poa pratensis – the species frequently sown in lawns. In the control treatments, distilled water was applied to the substrate. The experiment revealed that the effect of water extracts of leaves varied depending on their concentration and donor variety as well as the sensitivity of the acceptor (the test plant. In comparison with the control treatments, the strongest negative impact was caused by the cultivars 'Olivia' (F. rubraand 'Pintor' (F. ovina, followed by 'Asterix' (F. arundinacea. Among the acceptors, the greatest sensitivity to the presence of allelochemicals was shown by A. capillaris, and the smallest by F. arundinacea. .

  7. Double-Blind, Placebo-Controlled, Randomized Study Comparing 0.0003% Calcitriol with 0.1% Tacrolimus Ointments for the Treatment of Endemic Pityriasis Alba

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    Berenice Moreno-Cruz

    2012-01-01

    Full Text Available Background. Pityriasis alba (PA is a frequent cause of consultation in tropical areas due to its chronic course, frequent relapses, and notorious hypopigmented lesions in pediatric dark skin populations. Currently, no treatment is widely accepted. Objective. To assess the efficacy of 0.0003% calcitriol and 0.1% tacrolimus ointments compared with placebo in the treatment of endemic PA. Methods. Twenty-eight children aged 3–17 years with 56 symmetrical lesions and phototype IV-V, were randomly assigned to receive the treatments on target lesions on the face. Improvement was evaluated at baseline and 8 weeks later clinically and by digital quantification of the affected area, colorimetry, and transepidermal water loss (TEWL. Results. Tacrolimus and calcitriol ointments induced a mean improvement of 68%, compared to 44% of placebo. We found an elevated TEWL in PA lesions. In the treated plaques, the reduction of the affected area was associated with improvement of pigmentation and TEWL. Conclusions. Calcitriol and tacrolimus induced similar repigmentation in endemic PA lesions. Melanogenic, anti-inflammatory, and barrier defect restoration properties of these drugs may explain these findings.

  8. Is There a Link between Human Herpesvirus Infection and Toll-like Receptors in the Pathogenesis of Pityriasis Rosea? A Case-control Study.

    Science.gov (United States)

    El-Ela, Mostafa Abou; Shaarawy, Eman; El-Komy, Mohamed; Fawzy, Marwa; Hay, Rania Abdel; Hegazy, Rehab; Sharobim, Amin; Moustafa, Nadine; Rashed, Laila; Sayed Amr, Khalda Sayed

    2016-12-01

    Human herpesvirus (HHV) 6 and 7 are involved in the pathogenesis of pityriasis rosea (PR). Our aim was to evaluate the role of the innate immune response in PR through the detection of Toll-like receptors (TLR) 2, 3, 4, 7, 8, and 9 expression in the skin of affected patients and to detect the possibility of being induced by HHV-6 and/or HHV-7 viral coexistence in these patients. Twenty-four patients with PR and 24 healthy controls were included in this case-control study. Biopsy was obtained from the PR lesion and from the healthy skin of controls for detection of HHV-6 and 7 as well as TLRs 2, 3, 4, 7, 8, and 9 gene expression using real-time polymerase chain reaction (PCR). Significantly elevated expression of all studied TLRs and significantly higher viral load of HHV-6 and 7 in PR cases were detected. A significant higher expression of TLR2 and 4 in HHV-7 positive cases and a significant positive correlation between TLR9 and HHV-7 viral load were documented. HHV6 and 7 may also be involved in the pathogenesis of PR via TLR pathways.

  9. Research on the extraction and anti-oxidation of flavonoids in Myrica rubra marc%杨梅渣黄酮类化合物提取及其抗氧化活性研究

    Institute of Scientific and Technical Information of China (English)

    陈学丽; 叶立斌; 励建荣; 孙金才; 陈卫; 许庆炎; Zhou K.

    2011-01-01

    Myrica rubra is a specific fruit species in China, annual production of which is about 1 million tons, and Myrica rubra marc accounts for 10% of total weight of the fruit. At present,the food industry based on Myrica rubra resources has a certain scale, while the utilization of Myrica rubra marc is still blank. The fractions were acquired from Myrica rubra marc by a series of steps including extraction and concentration, followed by extraction with petroleum ether, ethyl acetate, n-butanol. The anti-oxidative activities of the extracts were evaluated in vitro,including DPPH radical scavenging activity, Fenton action and reducing power methods. The results showed that n-butanol fraction and ethyl acetate fraction of Myrica rubra marc crude extracts exhibited strong scavenging abilities for DPPH free radical,their half-inhibitory concentration (IC50)were 30μg/mL and 40μg/mL, respectively,and were approximately 3.67 times and 2.75 times as much as that of Vitamin C( 1 10μg/mL).%杨梅是我国的特产水果,年产量约为100万t,其中杨梅渣约占果实总重的10%.目前以杨梅为资源的食品工业已初具规模,然而在杨梅深加工过程中,杨梅渣都作为废物进行处理,对其开发利用仍然一片空白.基于此,以杨梅渣为研究对象,对杨梅渣中黄酮类化合物进行提取、浓缩、萃取,分成四个级分(石油醚相、乙酸乙酯相、正丁醇相和水相);用DPPH法、Fenton反应法和还原能力评价了四个不同级分的杨梅渣提取物的体外抗氧化能力.结果表明,杨梅渣粗提物正丁醇相和乙酸乙酯相具有较强的清除DPPH自由基能力,其半抑制浓度(IC50)分别为30、40μg/mL,分别是维生素C(IC50:110μg/mL)的3.67、2.75倍.

  10. Contributions to the phytocoenological study of the association Pulmonario rubrae-Fagetum (Soó 1964 Täuber 1987 in the Oraştie River basin (Central-Western Romania

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    Valeriu Ioan VINTAN

    2013-05-01

    Full Text Available In the current paper we present a phytocoenologic study of the phytocoenoses of the association Pulmonario rubrae-Fagetum (Soó 1964 Täuber 1987, identified in the Orăştie river basin, situated in the central-western part of Romania.The characterisation of the association under analysis as well as the presentation of the synthetic table have been done by selecting the most representative relevés performed in the mixed broadleaf-needleleaf forests of beech (Fagus sylvatica subsp. sylvatica, fir (Abies alba and spruce (Picea abies with Pulmonaria rubra belonging to the Orăştie river basin.The phytocoenoses of these forests were analysed in terms of physiognomy and floristic composition, life forms spectrum, floristic elements, and ecological indices.

  11. Studies on Characteristics of Androphyte Inflorescence and Pollination of Myrica rubra%杨梅雄株花序特性与授粉研究

    Institute of Scientific and Technical Information of China (English)

    柴春燕; 焦云; 徐绍清; 房聪玲; 胡志刚; 高中山

    2011-01-01

    对慈溪75株杨梅(Myrica rubra)雄株的雄花外观进行调查后,把雄花花序形状分为锥形、棒形、塔形、圆柱形4类,其中多数为锥形,占全部调查材料的62.7%,塔形和圆柱形分别仅有1份和2份;花序颜色可分为红、红黄、黄绿、玫瑰红4类,其中多数为红色,占全部调查材料的48.0%,玫瑰红仅有1份;花序长度0.8~3.8cm,多数2.0~2.9cm,占全部调查材料的64.0%;花序上着生小花数以20 ~ 29朵的为最多,占全部调查材料的82.6%;花粉量以锥形花序的为最多,圆柱形的次之,棒形的较少;雄花2月下旬苞片开裂,3月下旬至4月上旬出现盛花期,总花期长达35d左右.从所收集的资源中选取3份不同株系花粉分别在3个不同杨梅品种上进行人工授粉,结果表明人工授粉的座果率略低于自然授粉的座果率,用不同雄株的花粉座果率有差异.%The 75 androphytes inflorescence of Myrica rubra in Cixi were investigated for their morphological characters in Cixi, Zhejiang province. The results showed that the androphyte inflorescence emerged in late February, lasted until late March or early April, the total flowering time was about 35 days. The shape of the male inflorescence could be divided into four types: taper, club, tower, column, while the majority was taper (62.7%), the column and tower type had only one or two accessions. There weare four colors: red, red yellow, yellow green and rosy pink, about half of the investigated accessions awere red, only one rosy pink. The length of the inflorescence was in a range of 0.8 - 3.8 cm, most ranged from 2.0 to 2.9 cm (64.0% ). The flower numbers in each inflorescence awere most in a range of 20 - 29(82.6%).The taper inflorescence had largest amount of pollen, followed by the column, the club types. In addition, pollens collected from three accessions were tested on three different varieties of U. Rubra by artificial pollination, the results showed the

  12. Gianotti-Crosti syndrome, pityriasis rosea, asymmetrical periflexural exanthem, unilateral mediothoracic exanthem, eruptive pseudoangiomatosis and papular-purpuric gloves and socks syndrome: a brief review and arguments for diagnostic criteria

    Directory of Open Access Journals (Sweden)

    Antonio Chuh

    2012-02-01

    Full Text Available Several exanthems including Gianotti-Crosti syndrome, pityriasis rosea, asymmetrical periflexural exanthem, eruptive pseudoangiomatosis, and papular-purpuric gloves and socks syndrome are suspected to be caused by viruses. These viruses are potentially dangerous. Gianotti-Crosti syndrome is related to hepatitis B virus infection which is the commonest cause of hepatocellular carcinoma, and Epstein-Barr virus infection which is related to nasopharyngeal carcinoma. Pityriasis rosea has been suspected to be related to human herpesvirus 7 and 8 infections, with the significance of the former still largely unknown, and the latter being a known cause of Kaposi’s sarcoma. Papular-purpuric gloves and socks syndrome is significantly associated with human B19 erythrovirus infection which can lead to aplastic anemia in individuals with congenital hemoglobinopathies, and when transmitted to pregnant women, can cause spontaneous abortions and congenital anomalies. With viral DNA sequence detection technologies, false positive results are common. We can no longer apply Koch’s postulates to establish causeeffect relationships. Biological properties of some viruses including lifelong latent infection, asymptomatic shedding, and endogenous reactivation render virological results on various body tissues difficult to interpret. We might not be able to confirm or refute viral causes for these rashes in the near future. Owing to the relatively small number of patients, virological and epidemiology studies, and treatment trials usually recruit few study and control subjects. This leads to low statistical powers and thus results have little clinical significance.

  13. Pityriasis Rosea, Gianotti-Crosti Syndrome, Asymmetric Periflexural Exanthem, Papular-Purpuric Gloves and Socks Syndrome, Eruptive Pseudoangiomatosis, and Eruptive Hypomelanosis: Do Their Epidemiological Data Substantiate Infectious Etiologies?

    Science.gov (United States)

    Zawar, Vijay; Sciallis, Gabriel F.; Kempf, Werner; Lee, Albert

    2016-01-01

    Many clinical and laboratory-based studies have been reported for skin rashes which may be due to viral infections, namely pityriasis rosea (PR), Gianotti-Crosti syndrome (GCS), asymmetric periflexural exanthem/unilateral laterothoracic exanthem (APE/ULE), papular-purpuric gloves and socks syndrome (PPGSS), and eruptive pseudo-angiomatosis (EP). Eruptive hypomelanosis (EH) is a newly discovered paraviral rash. Novel tools are now available to investigate the epidemiology of these rashes. To retrieve epidemiological data of these exanthema and analyze whether such substantiates or refutes infectious etiologies. We searched for articles published over the last 60 years and indexed by PubMed database. We then analyzed them for universality, demography, concurrent patients, temporal and spatial-temporal clustering, mini-epidemics, epidemics, and other clinical and geographical associations. Based on our criteria, we selected 55, 60, 29, 36, 20, and 4 articles for PR, GCS, APE/ULE, PPGSS, EP, and EH respectively. Universality or multiple-continental reports are found for all exanthema except EH. The ages of patients are compatible with infectious causes for PR, GCS, APE/ULE, and EH. Concurrent patients are reported for all. Significant patient clustering is demonstrated for PR and GCS. Mini-epidemics and epidemics have been reported for GCS, EP, and EH. The current epidemiological data supports, to a moderate extent, that PR, GCS, and APE could be caused by infectious agents. Support for PPGSS is marginal. Epidemiological evidences for infectious origins for EP and EH are inadequate. There might be growing epidemiological evidence to substantiate or to refute our findings in the future. PMID:27103975

  14. Pityriasis rosea, Gianotti-Crosti syndrome, asymmetric periflexural exanthem, papular-purpuric gloves and socks syndrome, eruptive pseudoangiomatosis, and eruptive hypomelanosis: do their epidemiological data substantiate infectious etiologies?

    Directory of Open Access Journals (Sweden)

    Antonio Chuh

    2016-03-01

    Full Text Available Many clinical and laboratory-based studies have been reported for skin rashes which may be due to viral infections, namely pityriasis rosea (PR, Gianotti-Crosti syndrome (GCS, asymmetric periflexural exanthem/unilateral laterothoracic exanthem (APE/ULE, papularpurpuric gloves and socks syndrome (PPGSS, and eruptive pseudo-angiomatosis (EP. Eruptive hypomelanosis (EH is a newly discovered paraviral rash. Novel tools are now available to investigate the epidemiology of these rashes. To retrieve epidemiological data of these exanthema and analyze whether such substantiates or refutes infectious etiologies. We searched for articles published over the last 60 years and indexed by PubMed database. We then analyzed them for universality, demography, concurrent patients, temporal and spatial-temporal clustering, mini-epidemics, epidemics, and other clinical and geographical associations. Based on our criteria, we selected 55, 60, 29, 36, 20, and 4 articles for PR, GCS, APE/ULE, PPGSS, EP, and EH respectively. Universality or multiple-continental reports are found for all exanthema except EH. The ages of patients are compatible with infectious causes for PR, GCS, APE/ULE, and EH. Concurrent patients are reported for all. Significant patient clustering is demonstrated for PR and GCS. Mini-epidemics and epidemics have been reported for GCS, EP, and EH. The current epidemiological data supports, to a moderate extent, that PR, GCS, and APE could be caused by infectious agents. Support for PPGSS is marginal. Epidemiological evidences for infectious origins for EP and EH are inadequate. There might be growing epidemiological evidence to substantiate or to refute our findings in the future.

  15. Role of Malassezia in the color diversity of pityriasis versicolor%马拉色菌在花斑癣色素改变中的作用

    Institute of Scientific and Technical Information of China (English)

    崔凡; 余晓东; 李筱芳; 陈先进; 沈永年; 吕桂霞; 刘维达

    2008-01-01

    Objective To investigate the influence of Malassezia isolates that can cause hyperpigmentation or hypopigmentation in patients with pityriasis versicolor on the melanogenesis of B16F10 melanoma cells.and to detect the levels of cytokines associated with melanogenesis.Methods Primary culture of keratinocytes(1×106 cells/mL)derived from human prepuce were co-cultured with Malassezia strains isolated from hyperpigmented or hypopigmented lesions in the same patient with pityriasis versicolor,with the concentration ratio of keratinocytes to Malassezia cells being 1:1,1:10,1:20 and 1:30,respectively.The proliferation rate of keratinocytes was detected by MTT methOd.To observe the influence on B16F10 melanoma cells.five difierent types of culture supematant were prepared,i.e.the supematant from culture system of keratinocytes alone,supematant from the coculture system of keratinocytes and Malassezia isolates from hyperpigmented sites or hypopigmented sites,and supernatant from keratinocyte culture in the presence of Malassezia cell-free supematant from the culture medium of Malassezia strains from hyperpigmented or hypopigmented sites.ELISA test was performed in these supematants to detect the levels of several eytokines associated with melanogenesis,including basic fibroblast growth factor(b-FGF),endothelin-1,nerve growth factor(NGF)-β,IL-1α,lL-6,tumor necrosis factor(TNF)-α and stem cell factor(SCF).B16F10 cells were cultured with the above 5 supematants.After 48-hour culture.the proliferation rate of B16F10 cells was measured with MTT method,melanin content by NaOH assay.expression and activity of tyrosinase via Western blot and dopa-oxidase assay,respectively.Results The growth rate of keratinocytes was not affected by MalassczJa(P>0.05)when the concentration ratio of keratinocytes to Malassezia cells was more than 1:20.The melanin content,tyrosinase activity and expression of tyrosinase of B16F10 cells were inereased in the presence of supernatant from co

  16. 高压脉冲电场技术在杨梅保鲜中的应用研究%Study on the application of high pulse electric field technology in preserving Myrica rubra fruits

    Institute of Scientific and Technical Information of China (English)

    张雯; 韩其国; 朱英俊; 郑兴华; 何晶; 刘珂舟; 杨勇

    2012-01-01

    高压脉冲电场灭菌技术是国际上研究较为热门的非热灭菌技术之一。实验目的是探讨高压脉冲电场技术用于杨梅保鲜的可行性。工作电压100kV的高压脉冲电场由本实验室研制,将新鲜杨梅置于高压脉冲电场产品处理室中,设置不同电场参数(脉宽、频率、电场作用时间)对杨梅进行处理,通过分析对照组和处理组杨梅的pH变化以及气味、色泽等感官指标的变化来验证高压脉冲电场对杨梅的保鲜效果。结果显示影响杨梅保鲜的最主要因素是电场脉冲宽度,最佳的参数组合是脉宽10μs,频率80Hz,作用时间10s。结论:高压脉冲电场对杨梅保鲜有一定的效果。%High pulse electric field(HPEF) is a highly developing non-thermal sterilization technique in recent years. The aim was to investigate the feasibility of HPEF technique on keeping Myrica rubra fruits fresh.Samples of Myrica rubra fruits were put in the HPEF operate chamber, and then processed by setting different electric field parameters.By analyzing the changes of pH value, and sensory indexes such as smell and colour between the control group and dealing groups,the effect of Myrica rubra preservation by high pulse electric field could be invistigated.Results showed that:there was significant difference in pH value between control group and dealing groups;among the parameters ( pulse width, frequency and effect time) ,the most influencing factor to keep Myrica rubra fruits fresh was the pulse width ;the optimal parameter combination was pulse width for 10μs with frequency for 80Hz, and effect time for 10s. The results indicated that it was feasible by using high pulse electric field technology to keep Myrica rubra fruits fresh.

  17. The Influence of Sesquiterpenes from Myrica rubra on the Antiproliferative and Pro-Oxidative Effects of Doxorubicin and Its Accumulation in Cancer Cells.

    Science.gov (United States)

    Ambrož, Martin; Boušová, Iva; Skarka, Adam; Hanušová, Veronika; Králová, Věra; Matoušková, Petra; Szotáková, Barbora; Skálová, Lenka

    2015-08-21

    The sesquiterpenes β-caryophyllene, β-caryophyllene oxide (CAO), α-humulene (HUM), trans-nerolidol (NER), and valencene (VAL) are substantial components of the essential oil from Myrica rubra leaves which has exhibited significant antiproliferative effects in several intestinal cancer cell lines, with CaCo-2 cells being the most sensitive. The present study was designed to evaluate the effects of these sesquiterpenes on the efficacy and toxicity of the anticancer drug doxorubicin (DOX) in CaCo-2 cancer cells and in primary culture of rat hepatocytes. Our results showed that HUM, NER, VAL and CAO inhibited proliferation of CaCo-2 cancer cells but they did not affect the viability of hepatocytes. CAO, NER and VAL synergistically potentiated the efficacy of DOX in cancer cells killing. All sesquiterpenes exhibited the ability to selectively increase DOX accumulation in cancer cells and did not affect DOX concentration in hepatocytes. Additionally, CAO and VAL were able to increase the pro-oxidative effect of DOX in CaCo-2 cells. Moreover, CAO mildly ameliorated DOX toxicity in hepatocytes. Based on all results, CAO seems to be the most promising compound for further testing.

  18. The Influence of Sesquiterpenes from Myrica rubra on the Antiproliferative and Pro-Oxidative Effects of Doxorubicin and Its Accumulation in Cancer Cells

    Directory of Open Access Journals (Sweden)

    Martin Ambrož

    2015-08-01

    Full Text Available The sesquiterpenes β-caryophyllene, β-caryophyllene oxide (CAO, α-humulene (HUM, trans-nerolidol (NER, and valencene (VAL are substantial components of the essential oil from Myrica rubra leaves which has exhibited significant antiproliferative effects in several intestinal cancer cell lines, with CaCo-2 cells being the most sensitive. The present study was designed to evaluate the effects of these sesquiterpenes on the efficacy and toxicity of the anticancer drug doxorubicin (DOX in CaCo-2 cancer cells and in primary culture of rat hepatocytes. Our results showed that HUM, NER, VAL and CAO inhibited proliferation of CaCo-2 cancer cells but they did not affect the viability of hepatocytes. CAO, NER and VAL synergistically potentiated the efficacy of DOX in cancer cells killing. All sesquiterpenes exhibited the ability to selectively increase DOX accumulation in cancer cells and did not affect DOX concentration in hepatocytes. Additionally, CAO and VAL were able to increase the pro-oxidative effect of DOX in CaCo-2 cells. Moreover, CAO mildly ameliorated DOX toxicity in hepatocytes. Based on all results, CAO seems to be the most promising compound for further testing.

  19. Effects of Visual Grading on Northern Red Oak (Quercus rubra L. Seedlings Planted in Two Shelterwood Stands on the Cumberland Plateau of Tennessee, USA

    Directory of Open Access Journals (Sweden)

    Stacy L. Clark

    2015-10-01

    Full Text Available Artificial regeneration of oak has been generally unsuccessful in maintaining the oak component in productive upland forests of eastern North America. We tested visual grading effects on quality-grown northern red oak (Quercus rubra seedlings planted in two submesic stands on the Cumberland Plateau escarpment of Tennessee, USA. Seedlings were grown for one year using advanced fertilization and irrigation protocols to increase overall size of seedlings, but large variability in size was still evident. Seedlings were divided into two grades prior to planting. The “standard” grade represented seedlings that had undergone a light culling, and the “premium” grade represented the highest quality seedlings. Seven years after planting in a midstory-removal stand, 50 percent of trees survived, growth was negligible, and seedling grade had no effect on survival and yearly growth. In a shelterwood harvest stand, premium grade seedlings had taller height and larger basal diameter (BD (241 cm and 29.5 mm, respectively compared to standard seedlings (201 cm and 25.9 mm, respectively, and a two-year height growth advantage was achieved by planting premium grade compared to standard grade seedlings. Competitive ability and planting shock were similar between grades, and we postulate that an exceptional drought and large size variability in both grades equalized response. While our findings should be confirmed through additional testing, they suggest currently accepted seedling quality standards for northern red oak should be refined to improve regeneration efforts on productive sites in the eastern United States.

  20. Expression and function analysis of the metallo-thionein-like (MT-like) gene from Festuca rubra in Chlamydomonas reinhardtii chloroplast

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    The cDNA of the metallothionein-like (MT-like) gene from Festuca rubra cv. Merlin was optimized with bias codon of Chlamydomonous reinhardtii chloroplast genome. The optimized MT-like gene was de-livered into C. reinhardtii chloroplast and the transgenic strains expressing MT-like gene was obtained. PCR-Southern blot and RT-PCR-Southern blot analysis demonstrated that the MT-like gene was inte-grated into chloroplast genome of C. reinhardtii and expressed at the transcriptional level. The cad-mium binding capacity of the transgenic C. reinhardtii was determined by hydride generation-atomic fluorescence spectrometry (HG-AFS) and the binding properties were analyzed. Results showed that the transgenic C. reinhardtii expressing the MT-like gene exhibited remarkably higher Cd2+ binding capacity and grew to higher densities at toxic Cd2+ concentrations (40-100 μmol/L) than the wild type strain, and that the IC50 of Cd2+ (3-d treating ) to algal cell growth of transgenic strain was 55.43% higher than that of the wild type strain, indicating that the Cd2+ binding capacity and Cd2+ tolerance of C. reinhardtii was enhanced through the expression of the foreign MT-like gene in chloroplast.

  1. Contrasting patterns of population connectivity between regions in a commercially important mollusc Haliotis rubra: integrating population genetics, genomics and marine LiDAR data.

    Science.gov (United States)

    Miller, A D; van Rooyen, A; Rašić, G; Ierodiaconou, D A; Gorfine, H K; Day, R; Wong, C; Hoffmann, A A; Weeks, A R

    2016-08-01

    Estimating contemporary genetic structure and population connectivity in marine species is challenging, often compromised by genetic markers that lack adequate sensitivity, and unstructured sampling regimes. We show how these limitations can be overcome via the integration of modern genotyping methods and sampling designs guided by LiDAR and SONAR data sets. Here we explore patterns of gene flow and local genetic structure in a commercially harvested abalone species (Haliotis rubra) from southeastern Australia, where the viability of fishing stocks is believed to be dictated by recruitment from local sources. Using a panel of microsatellite and genomewide SNP markers, we compare allele frequencies across a replicated hierarchical sampling area guided by bathymetric LiDAR imagery. Results indicate high levels of gene flow and no significant genetic structure within or between benthic reef habitats across 1400 km of coastline. These findings differ to those reported for other regions of the fishery indicating that larval supply is likely to be spatially variable, with implications for management and long-term recovery from stock depletion. The study highlights the utility of suitably designed genetic markers and spatially informed sampling strategies for gaining insights into recruitment patterns in benthic marine species, assisting in conservation planning and sustainable management of fisheries.

  2. Effects of Northern red oak (Quercus rubra L. and sessile oak (Quercus petraea (Mattusch. Liebl. on the forest soil chemical properties

    Directory of Open Access Journals (Sweden)

    Miltner Stanislav

    2016-09-01

    Full Text Available Northern red oak (Quercus rubra L. is one of the most important introduced tree species in the Czech Republic, occupying about 6,000 ha with ca. 900,000 m3 of the standing volume. The presented study aims to evaluate its soil forming effects on natural oak sites. Soil chemistry of the upper soil layers (F+H, Ah, B horizons was studied in three pairs of stands of both species. In each stand, four bulk samples were taken separately for particular horizons, each consisting of 5 soil-borer cores. The soil characteristics analysed were: pH (active and potential, soil adsorption complex characteristics (content of bases, exchangeable cation capacity, base saturation, exchangeable acidity (exchangeable Al and H, total carbon and nitrogen content, and plant available nutrients content (P, K, Ca, Mg. Total macronutrient content (P, K, Ca, Mg was analysed only in holorganic horizons. Results confirmed acidification effects of red oak on the upper forest soil layers such as decreased pH, base content, base saturation, all nutrient contents in total as well as plant-available form and increased soil exchangeable acidity (exchangeable Al in comparison to the sessile oak stands, especially in holorganic horizons and in the uppermost mineral layer (Ah horizon. Northern red oak can be considered as a slightly site-soil degrading species in the studied sites and environmental conditions in comparison to native oak species.

  3. Occurrence of Encephalitozoon intestinalis in the Red ruffed lemur (Varecia rubra) and the Ring-tailed lemur (Lemur catta) housed in the Poznan Zoological Garden, Poland.

    Science.gov (United States)

    Słodkowicz-Kowalska, Anna; Majewska, Anna C; Trzesowska, Ewa; Skrzypczak, Łukasz

    2012-01-01

    Encephalitozoon intestinalis is one of the most common microsporidial species found in humans worldwide but it has rarely been identified in animals. The presence of this pathogen has been detected in a few species of domestic, captive and wild mammals as well as in three species of birds. The aim of the present study was to examine fecal samples obtained from mammals housed in the Poznan Zoological Garden, Poland, for the presence of potentially human-infectious microsporidia. A total of 339 fresh fecal samples collected from 75 species of mammals belonging to 27 families and 8 orders were examined for the presence of microsporidian spores. Microsporidian spores were identified in 3 out of 339 (0.9%) examined fecal samples. All samples identified as positive by chromotrope 2R and calcofluor white M2R were also positive by the FISH assay. Using multiplex FISH in all 3 fecal samples, only spores of E. intestinalis were identified in 2 out of 14 Ring-tailed lemurs (Lemur catta) and in one out of 17 Red ruffed lemurs (Varecia variegata rubra). To our knowledge this is the first diagnosis of E. intestinalis in Ring-tailed and Red ruffed lemurs. It should be mentioned that both lemur species are listed by the IUCN Red List of Threatened Species. Although the lemurs were asymptomatically infected, the possibility of widespread infection or death of these animals remains in the event of an elevated stress or a decrease in their immunological functions.

  4. Expression and function analysis of the metallo-thionein-like (MT-like) gene from Festuca rubra in Chlamydomonas reinhardtii chloroplast

    Institute of Scientific and Technical Information of China (English)

    HAN SiHai; HU ZhangLi; LEI AnPing

    2008-01-01

    The cDNA of the metallothionein-like (MT-like) gene from Festuca rubra cv. Merlin was optimized with bias codon of Chlamydomonous reinhardtii chloroplast genome. The optimized MT-like gene was delivered into C. reinhardtii chloroplast and the transgenic strains expressing MT-like gene was obtained. PCR-Southern blot and RT-PCR-Southern blot analysis demonstrated that the MT-like gene was integrated into chloroplast genome of C. reinhardtii and expressed at the transcriptional level. The cadmium binding capacity of the transgenic C. reinhardtii was determined by hydride generation-atomic fluorescence spectrometry (HG-AFS) and the binding properties were analyzed. Results showed that the transgenic C. reinhardtii expressing the MT-like gene exhibited remarkably higher Cd2+ binding capacity and grew to higher densities at toxic Cd2+ concentrations (40-100 μmol/L) than the wild type strain, and that the IC50 of Cd2+ (3-d treating) to algal cell growth of transgenic strain was 55.43% higher than that of the wild type strain, indicating that the Cd2+ binding capacity and Cd2+ tolerance of C. reinhardtii was enhanced through the expression of the foreign MT-like gene in chloroplast.

  5. Inter-sectional hybrids obtained from reciprocal crosses between Begonia semperflorens (section Begonia) and B. 'Orange Rubra' (section Gaerdita × section Pritzelia).

    Science.gov (United States)

    Chen, Yen-Ming; Mii, Masahiro

    2012-06-01

    Inter-sectional hybrids were successfully obtained by the reciprocal crosses between 11 cultivars (including 6 diploids and 5 tetraploids) of Begonia semperflorens (SS & SSSS genomes) and B. 'Orange Rubra' (RR genome) with the aid of in vitro culture of mature or immature seeds on MS medium containing 0.1 mg l(-1) α-naphthylacetic acid, 0.1 mg l(-1) 6-benzyladenine, 10 mg l(-1) gibberellic acid, 30 g l(-1) sucrose and 2.5 g l(-1) gellan gum. Embryo rescue as ovary culture with immature seeds 12(th)-16(th) day after pollination (DAP) generally gave higher efficiency of plantlet formation, but in some cross combinations, culture of mature seeds (30 DAP) resulted in higher yield of plantlets. Flow cytometric analysis revealed that they were consisted of the plants with various genomic combinations (RS, RR, RSS, RRS, RRSS and RRRRSS) as estimated by the DNA contents of both parents. Hybridity of these plants with various genomic combinations including RR was confirmed by random amplified polymorphic DNA analysis. These results suggested that unreduced gamete formation and spontaneous chromosome doubling were involved in the hybrid formation of various ploidy levels and genomic combinations. These hybrids showed various levels of intermediate traits between both parents according to the genomic compositions, and some of them had desirable characters of both parents.

  6. Centrifugal partition extraction, a new method for direct metabolites recovery from culture broth: case study of torularhodin recovery from Rhodotorula rubra.

    Science.gov (United States)

    Ungureanu, Camelia; Marchal, Luc; Chirvase, Ana Aurelia; Foucault, Alain

    2013-03-01

    Centrifugal partition extraction (CPE), close to centrifugal partition chromatography, put in contact in a continuous way two immiscible liquid phases. This work presents early experiments on CPE use for solid-liquid-liquid extraction. It was applied to the direct treatment of culture broth for metabolites recovery. Torularhodin is one of the carotenoid pigments produced by the yeast Rhodotorula sp., with a terminal carboxylic group considered nowadays as a powerful antioxidant to be included in food and drugs formulations. Torularhodin was extracted from Rhodotorula rubra ICCF 209 cells by CPE. The recovery of torularhodin reaches 74 μg/g of biomass i.e. 294 μg/L of culture medium. The efficiency of the extraction step increased with the operating flow rate. The extraction yield could reach 91% with a contact time lower than 2 min. A 300 mL apparatus allowed a feed at 90 mL/min. The technique is proposed for extraction or sample preparation before analysis.

  7. Pityriasis lichenoides et varioliformis acuta with numerous CD30(+) cells: a variant mimicking lymphomatoid papulosis and other cutaneous lymphomas. A clinicopathologic, immunohistochemical, and molecular biological study of 13 cases.

    Science.gov (United States)

    Kempf, Werner; Kazakov, Dmitry V; Palmedo, Gabriele; Fraitag, Sylvie; Schaerer, Leo; Kutzner, Heinz

    2012-07-01

    Pityriasis lichenoides comprises a clinicopathologic spectrum of cutaneous inflammatory disorders, with the 2 most common variants being pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis lichenoides chronica. The aim of the study was to describe 13 cases of a unique PLEVA variant characterized in the conspicuous CD30 component and thus mimicking lymphomatoid papulosis (LyP), a condition currently classified in the spectrum of CD30 lymphoproliferative disorders. The cohort included 10 female and 3 male patients whose ages at diagnosis ranged from 7 to 89 years (mean 41 y; median 39 y). The clinical manifestation was that of PLEVA, with small erythematous macules quickly evolving into necrotic papules. No waxing and waning was seen on follow-up in any of the cases. Histopathologically, typical features of PLEVA were present, but an unusual finding was occurrence of a considerable number of CD30 small lymphocytes as detected immunohistochemically. Over half of the cases also displayed a large number of CD8 cells and showed coexpression of CD8 and CD30 in the intraepidermal and dermal component of the infiltrate. Of the 11 cases of PLEVA studied for T-cell receptor gene rearrangement, 6 evidenced a monoclonal T-cell population, and 5 were polyclonal. Parvovirus B19 (PVB19) DNA was identified in 4 of 10 cases investigated, and positive serology was observed for PVB19 in 2 patients, altogether suggesting that PVB19 is pathogenetically linked to PLEVA at least in a subset of cases. The presence of CD30 lymphocytes and CD8 lymphocytes would be consistent with an inflammatory antiviral response, as CD30, even atypically appearing lymphoid cells have been identified in some viral skin diseases. The main significance of the PLEVA variant is, however, its potential confusion with LyP or some cytotoxic lymphomas. Admittedly, the CD30 PLEVA variant described herein and LyP show considerable overlap if one takes into account all known variations of the 2

  8. Nitrogen fixation and growth response of Alnus Rubra following fertiliztion with urea or biosolids Fixação de nitrogênio e crescimento de Alnus Rubra fertilização com uréia ou biosólidos

    Directory of Open Access Journals (Sweden)

    Linda S. Gaulke

    2006-08-01

    Full Text Available Nitrogen fertilization of forests using biosolids offers a potentially environmentally friendly means to accelerate tree growth. This field study was designed to analyze the effects of nitrogen fertilization on the symbiotic, nitrogen (N-fixing relationship between Alnus rubra Bong. (red alder and Frankia. Anaerobically digested, class B biosolids and synthetic urea (46% N were applied at rates of 140, 280 and 560 kg ha-1 available N to a well-drained, sandy, glacial outwash soil in the Indianola series (mixed, mesic Dystric Xeropsamments. Plots were planted with A. rubra seedlings. At the end of each of two growing seasons trees were harvested and analyzed for the rate of N fixation (as acetylene reduction activity, biomass and foliar N. At year 1, there was no N fixation for trees grown with urea amendments, but control (17 µmol C2H4 g-1 hr-1 and biosolids (26-45 µmol C2H4 g-1 hr-1 trees were fixing N. At the end of year 2, all trees in all treatments were fixing N (7 µmol C2H4 g-1 hr-1, 4-16 µmol C2H4 g-1 hr-1, and 20-29 µmol C2H4 g-1 hr-1 for control, urea and biosolids respectively. Trees grown with biosolids amendments were larger overall (year 1 shoot biomass 10 g, 5 g, and 23 g for control, urea, and biosolids respectively, year 2 shoot biomass 50 g, 51 g, and 190 g for control, urea, and biosolids respectively with higher concentrations of foliar N for both years of the study (year 1 foliar N 26 g kg-1, 27 g kg-1, and 40 g kg-1 for control, urea, and biosolids respectively, year 2 foliar N 17 g kg-1, 19 g kg-1, and 23 g kg-1 for control, urea, and biosolids respectively. Trees grown with urea amendments appeared to use the urea N over Frankia supplied N, whereas the biosolids trees appeared to be able to use both N in biosolids and N from Frankia. The results from this study indicated that the greater growth of A. rubra may have been responsible for the observed higher N demand. Biosolids may have supplied other nutrients to the

  9. Experimental Study on the Effect of Extractive of Radix Paeoniae Rubra to Streptococcus mutans%赤芍粗提物对变形链球菌影响的实验研究

    Institute of Scientific and Technical Information of China (English)

    邵旭媛; 俞晓峰; 冯岩; 林挺; 苏柏华; 卢友光

    2011-01-01

    Objective To investigate the effect of extractive of radix paeoniae rubra on the growth, acidogenicity, adhesion and glucan production of Streptococcus mutans ( S. mutans), and to explore the possibility of radix paeoniac rubra as an anti-caries agent. Methods S. mutans ATCC 25175 were chosen. The extractive of radix paeoniae rubra was carried out, and then the effect of extractive of radix paconiae rubra on the growth, acidogenicity, adhesion and glucan production was assessed. Results It was found that the minimal inhibitory concentration (MIC) was 12.5 g/L. When the concentration of the extractive was higher than 3.13 g/L, the acidogenicity, adhesion, adhesion and soluble glucan production of S. mutans can be inhibited. And when the concentration was above 6.25 g/L, the insoluble glucan production of S. mutans can be inhibited. Conclusion The extractive of radix paeoniae rubra above a certain concentration has inhibitory effect on S. mutans. It indicates that radix paeoniae rubra may have anti-caries effect.%目的 研究赤芍粗提物对变形链球菌的生长、产酸、粘附及合成胞外多糖的影响.方法 采用倍比稀释法测定不同浓度赤芍粗提物抑制变形链球菌牛长的情况,通过统计学方法确定最低抑菌浓度(minimal inhibito-ry eoneentmtion,MIC);再以MIC及低于MIC的4个倍比稀释浓度配制含药的胰酶解酪蛋白-植物蛋白胨-酵母提取物(trypticase-phytone-yeast extract medium,TPY)液体培养基,测定赤芍粗提物对变形链球菌产酸、粘附及合成胞外多糖能力的影响.结果 赤芍粗提物抑制变形链球菌体外牛长的MIC为12.5 g/L;当赤芍粗提物浓度≥3.13 g/L时有较明显地抑制变形链球菌产酸、粘附、合成水溶性胞外多精的作用;当赤芍粗提物浓度≥6.25 s/L时能明显抑制变形链球菌合成水不溶性胞外多糖.结论 达到一定浓度的赤芍粗提物对变形链球菌的生长、产酸、粘附及合成胞外多精均有一定的抑制作用.

  10. Effects of distilled Phaseoli Semen rubra Herbal-Acupuncture on lipid composition, liver function, antioxidant capacity and molecular biological aspects in obese rats induced high fat diet

    Directory of Open Access Journals (Sweden)

    Ji, Jun Hwan

    2005-06-01

    Full Text Available Effects of Phaseoli Semen rubra Herbal-acupuncture at zusanli(ST-36, Quchi(LI-11 and Sanyinjiao(Sp-6 on lipid composition, liver function, oxidative capacity and molecular biological aspects were investigate in high fat diet induced obese rats. Forty male Sprague-Dawley rats weighing about 400g were divided into 4 groups according to body weight and raised four weeks with control, zusanli(ST-36, Quchi(LI-11 and Sanyinjiao(Sp-6 Herbal-acupuncture groups. 1. Plasma total cholesterol and LDL-cholesterol showed a low values in the (ST-36 and (LI-11 Herbal-acupuncture groups and HDL- cholesterol showed a high values in the (ST-36 Herbal-acupuncture groups. 2. Plasma triglyceride and glucose showed a low values in the (ST-36 and (LI-11 Herbal-acupuncture groups. 3. The contents of plasma free fatty acids showed a tendence to decrease in the Herbal-acupuncture groups, however in the Herbal-acupuncture groups, the values showed no significantly different. 4. The activities of AST and ALT showed no significantly different in all treatment groups. 5. The contents of plasma β-lipoprotein and free fatty acids showed a tendency to decrease in the Herbal-acupuncture groups compared to those of control group. In the Herbal-acupuncture groups, the values of (ST-36 and (LI-11 Herbal-acupuncture groups showed a low in the acupuncture groups. 6. Liver total cholesterol and triglyceride showed a low values in the (ST-36 and (LI-11 Herbal-acupuncture groups. 7. Contents of plasma TBARS showed a low values in the (ST-36 and (LI-11 Herbal-acupuncture groups, however contents of liver TBARS showed no significantly different among treatment groups. 8. Values of liver glutathione peroxidase and catalase activity showed a tendency to increase in the (ST-36 and (LI-11 Herbal-acupuncture groups. Values of liver super oxide dismutase activity showed a high in the (ST-36 Herbal-acupuncture groups compared to those of other groups. 9. Expression of apo-B mRNA in liver cell

  11. Evaluation of the grass mixture (Faestuca Rubra, Cynodon Dactylon, Lolium Multiflorum and Pennisetum sp.) as Sb phyto-stabilizer in tailings and Sb-rich soils.

    Science.gov (United States)

    Aurora Armienta, M.; Beltrán-Villavicencio, Margarita; Ruiz-Villalobos, Carlos E.; Labastida, Israel; Ceniceros, Nora; Cruz, Olivia; Aguayo, Alejandra

    2017-04-01

    Green house experiments were carried out to evaluate the growth and Sb assimilation of a grass assemblage: Faestuca Rubra, Cynodon Dactylon, Lolium Multiflorum and Pennisetum sp, in tailings and Sb-rich soils. Tailings and soil samples were obtained at the Mexican historical mining zone of Zimapán, Central México. More than 6 tailings impoundments are located at the town outskirts and constitute a contamination source from windblown and waterborne deposit on soils, besides acid mine drainage. Four substrates were used in the experiments: 100% tailings, 20% tailings + 80% soil, 50% tailings + 50% soil , and a soil sample far from tailings as a background. Concentrations of Sb ranged from 310 mg/kg to 413 mg/kg in tailings. A pH of 7.43, 1.27% organic matter, and high concentrations of N, K and P indicated adequate conditions for plant growth. The grass assemblage was raised during 21 days as indicated by OECD (Organisation for Economic Co-operation and Development) Guideline 208 Terrestrial Plant Test: Seedling Emergence and Seedling Growth Test. The highest Sb concentrations were measured in plants grown on tailings with 139 mg/kg in the aerial part and 883 mg/kg in roots. Concentrations of Sb decreased as the proportion of tailings diminished with 22.1 mg/kg in the aerial part and 10 mg/kg in roots corresponding to the plants grown in the 20 % tailings + 80% soil . Bioaccumulation (BAC) and bioconcentration factors (BF) of plants grown on tailings (BAC= 0.42, BCF=3.93) indicated their suitability as a phyto-stabilization option. The grass mixture may be thus applied to control windblown particulate tailings taking advantage to their tolerance to high Sb levels.

  12. Analysis of volatile oil in Rhizoma Ligustici Chuanxiong-Radix Paeoniae Rubra by gas chromatography-mass spectrometry and chemometric resolution

    Institute of Scientific and Technical Information of China (English)

    Xiao-ru LI; Yi-zeng LIANG; Fang-qiu GUO

    2006-01-01

    Aim:To analyze the volatile chemical components of the herbal pair Rhizoma Ligustici Chuanxiong-Radix Paeoniae Rubra (RLC-RPR) and compare them with those of each of the herbs alone.Methods:Gas chromatography-mass spectrometry (GC-MS) ,a chemometric resolution technique using the heuristic evolving latent projections (HELP) method.and the overall volume integration method were used.Results:In total,52,38,and 61 volatile chemical components in RLC,RPR,and RLC-RPR essential oils were determined,respectively,accounting for 95.14%,95.19%,and 89.68%ofthe total contents ofessential oil ofRLC,RPR,and RLC-RPR,respectively.The majn volatile chemical components were butyldienephthalide (20.65%) and ligustilide (50.15%) for RLC;and n-hexadecanoic acid (20.18%) ,[Z,Z]9,12-octadecadienoic acid (30.11%) ,2-hydroxy-benzaldehyde (17.08%) for RPR,and butyldienephthalide (14.80%) ,and ligustilide (38.91%) for RLC-RPR.The main volatile chemical components of RLC-RPR were almost the same as those of RLC,but the relative amounts were altered.Conclusion:The number of volatile chemical components in RLC-RPR was almost equal to the sum of the number in the 2 constituent herbs.but the relative amounts were altered.Furthermore,an acid-base reaction takes place during the process of decocting the herbs.The data gathered in this study may be helpful for understanding the synergistic nature of this herb pair in traditional Chinese medicine.

  13. Purification of Flavonoids from Chinese Bayberry (Morella rubra Sieb. et Zucc. Fruit Extracts and α-Glucosidase Inhibitory Activities of Different Fractionations

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    Shuxia Yan

    2016-08-01

    Full Text Available Chinese bayberry (Morella rubra Sieb. et Zucc. fruit have a diverse flavonoid composition responsible for the various medicinal activities, including anti-diabetes. In the present study, efficient simultaneous purification of four flavonoid glycosides, i.e., cyanidin-3-O-glucoside (1, myricetin-3-O-rhamnoside (2, quercetin-3-O-galactoside (3, quercetin-3-O-rhamnoside (4, from Chinese bayberry pulp was established by the combination of solid phase extract (SPE by C18 Sep-Pak® cartridge column chromatography and semi-preparative HPLC (Prep-HPLC, which was followed by HPLC and LC-MS identification. The purified flavonoid glycosides, as well as different fractions of fruit extracts of six bayberry cultivars, were investigated for α-glucosidase inhibitory activities. The flavonol extracts (50% methanol elution fraction of six cultivars showed strong α-glucosidase inhibitory activities (IC50 = 15.4–69.5 μg/mL, which were higher than that of positive control acarbose (IC50 = 383.2 μg/mL. Four purified compounds 1–4 exerted α-glucosidase inhibitory activities, with IC50 values of 1444.3 μg/mL, 418.8 μg/mL, 556.4 μg/mL, and 491.8 μg/mL, respectively. Such results may provide important evidence for the potential anti-diabetic activity of different cultivars of Chinese bayberry fruit and the possible bioactive compounds involved.

  14. Identificação de espécies de Malassezia em pacientes com pitiríase versicolor em Goiânia-GO Identification of Malassezia species in patients with pityriasis versicolor in Goiânia-GO

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    Karla Carvalho Miranda

    2006-12-01

    Full Text Available O objetivo deste estudo foi verificar a freqüência de pitiríase versicolor e identificar leveduras do gênero Malassezia, de pacientes encaminhados ao laboratório de Micologia da Universidade Federal de Goiás em Goiânia. Foram diagnosticados 95 casos de pitíriase versicolor e identificados quatro espécies de Malassezia: Malassezia furfur, Malassezia sympodialis, Malassezia globosa e Malassezia obtusa.The objectives of this study were to investigate the frequency of pityriasis versicolor occurrence and to identify yeasts of the genus Malassezia in patients at the mycology laboratory of the Federal University of Goiás, in Goiânia, State of Goiás. Ninety-five cases of pityriasis versicolor were diagnosed, and four species of Malassezia were identified: Malassezia furfur, Malassezia sympodialis, Malassezia globosa and Malassezia obtusa.

  15. Optimization of Fermentation Conditions for Producing Rhodotorula rubra JLC with Waste Tobacco Stems%废弃烟梗发酵生产深红酵母的工艺条件优化

    Institute of Scientific and Technical Information of China (English)

    吉彦龙; 席宇; 李敏睿; 杨帆; 杨高举; 张国帅; 朱大恒; 肖春生

    2013-01-01

    Plackett-Burman design was used to screen the major factors affecting fermentation production of a carotenoids-rich Rhodotorula rubra JLC from waste stems. The results showed that among the 11 tested factors, cane sugar, NaH2PO4, KH2PO4 and culture time significantly affected yeast yield. In Plackett-Burman experiments, the dry weight of maximum biomass reached 20.63 g/L.%以废弃烟梗水提取液(Tobacco stem extraction,TSE)为主要基质,采用Plackett-Burman设计法对影响发酵生产富含类胡萝卜素的深红酵母(Rhodotorula rubra)JLC生物量的1 1个主要因子进行了筛选.结果表明:蔗糖、NaH2PO4、KH2PO4和培养时间对酵母生物量有显著影响,在Plackett-Burman试验中,JLC最大生物量干重为20.63 g/L.

  16. Soil physical and chemical properties and fruit quality with grass cover in a Myrica rubra orchard%生草栽培对杨梅果园土壤理化性质和果实品质的影响

    Institute of Scientific and Technical Information of China (English)

    颜晓捷; 黄坚钦; 邱智敏; 努尔阿米娜·热合曼; 朱旻华; 吴家森

    2011-01-01

    为了解生草栽培对杨梅Myrica rubra果园土壤养分与果实品质的影响,在浙江省仙居县杨梅主产区设置了大绿豆Phaseolus radiatus,天然生草和清耕(对照)3个处理,连续处理3a后采集林地土壤和杨梅果实样品进行分析.结果表明:3a的生草栽培,杨梅林地土壤pH值有所提高,但差异不显著;与清耕对照相比,0~20 cm土壤有机质、碱解氮、有效磷增幅分别为25.2%~48.9%,7.3%~10.5%,82.1%~291.1%,生草栽培也使杨梅产量提高了1 350~2 250 kg·hm-2,使可溶性固形物增加6.7%~20.0%,维生素C增加42.6%~51.1%,还原糖增加17.0%~25.1%,总糖增加9.7%~14.9%,而总酸则减少16.5%~35.4%,固酸比增加4.2%~6.2%.相关分析表明:林地土壤有机质能显著影响杨梅果实品质,栽培生草或采取免耕等均能提高杨梅林地土壤有机质,从而提高杨梅果实品质.%To understand the effect of grass coverage on soil nutrition and fruit quality in a Myrica rubra orchard, the effects of three treatments: mung beans, natural grass, and clean tillage at the 0-20 cm and 20-40 cm depth-in the main producing areas of Xianju County, Zhejiang Province were investigated. After three years, the soil and fruit of M. rubra were collected and analyzed using a correlation analysis. Results showed that soil pH increased with grass cultivation, and compared with clean tillage, for the 0-20 cm soil depth, there were increases in organic matters (25.2%- 48.9%), available N (7.3%-10.5%), and available P (82.1%-291.1%). Compared with clean tillage, production of M. rubra for the other two treatments increased 1 350-2 250 kg·hm-2 with increases in soluble solids (6.7%-20.0%), vitamin C (42.6%-51.1%), reducing sugars (17.0%-25.1%), and total sugar content (9.7%-14.9%). However, total acids decreased 16.5%- 35.4%. The soluble solid content (SSC) / titratable acidity (TA) ratio increased 4.2%-6.2%. Also, the correlation analysis

  17. 483例儿童花斑癣回顾性分析%Pityriasis versicolor in children: a retrospective study of 483 cases

    Institute of Scientific and Technical Information of China (English)

    施和建; 张国龙; 杜旭峰; 周晴; 王涛; 邵敏华; 黄海峰

    2008-01-01

    目的总结及分析儿童花斑癣患者的临床特点,比较与成人花斑癣的异同点.方法就诊于我院皮肤科门诊的花斑癣患者认真填写问卷调查表,内容包括:性别、年龄、发病年龄,病程、皮损部位、诱因、发病季节、家族史.并进行真菌学检查.结果儿童花斑癣患者共483例,其中男286例,占59.2%,女197例,占40.8%.年龄15天至12岁.所有患儿面部发病207例,占42.9%,其中发生于前额的共143例,占面部发病的69.1%.多汗患儿405例,占83.9%.有家族史38例,占7.9%.所有患儿均采用1%联苯苄唑乳膏外用,治疗2周以上,447例患儿通过治疗后得到有效的临床症状改善及病原学疗效,总有效率为92.5%.结论儿童花斑癣同成人花斑癣比较有不同的临床特点,发病因素与成人不尽相同,且在诊断上需与儿童面部色素减退性皮肤病进行鉴别.%Objective To assess the clinical characteristics of pityriasis versicolor (PV) in children vs adults. Methods Questionnaire was designed and given to consecutive patients with PV in the Department of Dermatology, Wuxi Children's Hospital, for collection of information on their sex, age, onset age, duration of disease, localization of lesions, inducement, onset season, and family history. Findings on mycological examination before and after medication were assessed. Results Totally, 483 children with PV were enrolled, including 286 (59.2%) boys and 197 (40.8%) girls. Patients aged from 15 days to 12 years. Facial lesions were the most frequent (n = 207, 42.9% ) manifestation with a preference on the forehead (n = 143, 69.1% ). Hyperhidrosis was found in 405 (83.9%) patients, and family history of PV in 38 (7.9%) patients. Patients were instructed to apply bifonazole 1% cream on lesions. After more than 2 weeks of treatment, 447 (92.5%) patients obtained both clinical and mycological improvement. Conclusions Difference is present between pediatric and adult PV in clinical manifestations

  18. Effect of Radix Paeoniae Rubra on the expression of HO-1 and iNOS in rats with endotoxin-induced acute lung injury

    Institute of Scientific and Technical Information of China (English)

    ZHAN Li-ying; XIA Zhong-yuan; CHEN Chang; WANG Xiao-yuan

    2006-01-01

    Objective: To investigate the effect of Radix Paeoniae Rubra (RPR) on the expression of heme oxygenase ( HO-1 ) and induced nitric oxide synthase (iNOS) in endotoxininduced acute lung injury in rats and its protective mechanism.Methods: Forty Wistar rats were divided randomly into 5 groups with 8 rats in each group: saline control group ( NS group ), lipopolysaccharide group ( LPS group), RPR-treatment group, RPR-prevention group and Herin group. The effect of RPR on protein content, the ratio of neutrophiles in bronchoalveolar lavage fluid,malondialdehyde (MDA) content in the lung and the activity of serum NO were observed. Arterial blood was drawn for blood-gas analysis. The expression of HO-1 and iNOS in lung tissues was detected by immunohistochemitry and morphometry computer image analysis. The histological changes of the lung were observed under light microscope.Results: Compared with that in NS group, the expression of HO-1 and iNOS was markedly increased in LPS group (P < 0.01). In RPR-treatment, RPR-prevention, and Hemin groups, the expression of iNOS was significantly lower, while the expression of HO-1 was higher than that in LPS group (P <0.05). The protein content,the ratio of neutrophiles in bronchoalveolar lavage fluid,the content of MDA and the activity of serum NO in LPS group were significantly higher than those in NS group (P < 0.01 ). There was a significant decrease in the level of arterial bicarbonate and partial pressure of oxygen in the LPS group (P<0.01); these parameters of lung injury however, were significantly lower in RPR-treatment, RPR-prevention, and Hemin groups than LPS group (P <0.05or P < 0.01). The pathologic changes of lung tissues were substantially attenuated in RPR-treatment, RPR-prevention, and Hemin groups than LPS group.Conclusions : The high expression of HO-1 reflects an important protective function of the body during lipopolysaccharide-induced acute lung injury. The protective effect of RPR on

  19. 紫羊茅新品系抗旱性比较研究%Comparative Research on Drought Resistance of Festuca rubra L.Strains

    Institute of Scientific and Technical Information of China (English)

    陈涛; 李健; 白史且; 张昌兵; 鄢家俊; 李达旭; 游明鸿

    2011-01-01

    In this paper,base on the relative water content,chlorophyll content,the relative conductance rate and the malondiadehyde(MDA),The drought resistance were studied for Festuca rubra L.strains("SAGS-05054","SAGS-05055",and "SAGS-05056") and one control-"Polar".The main results showed as fallows:Under drought stress,the relative water content(RWC) and chlorophyll content were in a decreasing trend;the relative conductance rate(RPP) and the malondiadehyde(MDA) presented increase;the dissociated praline(Pro) presented first increasing then descending.The drought coefficients of five physiological parameters were evaluated by subordinate function analysis.The capacity of drought resistance of the four varieties was ordered as follows:"SAGS-05056""polar""SAGS-05055""SAGS-05054".%试验以3个紫羊茅新品系(SAGS-05054,SAGS-05055,SAGS-05056)为材料,以国外品种"极地"紫羊茅为对照,从相对含水量、细胞膜透性(RPP)、游离脯氨酸(Pro)、丙二醛(MDA)等方面对紫羊茅品系抗旱性进行系统评价,结果表明:模拟干旱胁迫下,供试材料叶片含水量和叶绿素总含量总体呈递减趋势,相对电导率和丙二醛含量呈递增趋势,游离脯氨酸含量先递增,达峰值后略微下降,各测定生理指标间相关性均达极显著。隶属函数抗旱性分析排序:"SAGS-05056"〉"极地"〉"SAGS-05055"〉"SAGS-05054"。

  20. Malassezia Species and Pityriasis Versicolor

    National Research Council Canada - National Science Library

    Rodoplu, Gulin

    2016-01-01

    Malassezia species are found in part of the normal human cutaneous commensal flora, however it has been known for many years that the Malassezia yeasts are associated with a number of different human...

  1. Nitrogen fixation and growth response of Alnus rubra amended with low and high metal content biosolids Crescimento e fixação de nitrogênio por Alnus rubra cultivado sob fertilização com biosólidos com altos e baixos teores de metais

    Directory of Open Access Journals (Sweden)

    Linda S. Gaulke

    2006-08-01

    Full Text Available Forest application of biosolids offers a potential environmentally friendly alternative to landfilling. This two-year investigation was designed to analyze the effects of elevated soil metal concentration resulting from the land application of biosolids on the symbiotic, nitrogen (N fixing relationship between Alnus rubra Bong. (red alder and Frankia. High metal biosolids and a modern-day composted biosolid applied at high loading rates of 250, 500, and 1000 Mg ha-1, were used to represent a worst-case scenario for metal contamination. The high metal biosolids were obtained before the current regulations were formulated and had been lagooned prior to use in this study. Total cadmium (Cd, lead (Pb and zinc (Zn in the high metal biosolids were 45, 958, and 2623 mg kg-1 respectively. These metal concentrations are above current regulatory limits in the US. The compost was made using biosolids that are currently produced and had Cd, Pb and Zn of 0.8, 20 and 160 mg kg-1 respectively. Trees were harvested and analyzed for rate of N fixation (as measured by acetylene reduction activity, biomass, and foliar metals. Soils were analyzed for available N, total carbon and N, pH and total Cd, Pb and Zn. Rates of N fixation were not affected by soil amendment. In year 2, shoot biomass of trees grown in both the compost and high metal amendments were higher than the control. Shoot biomass increased with increasing amount of compost amendments, but decreased with increasing amount of high metal amendments. There was no relationship between soil metal concentration and plant biomass. Foliar Cd and Pb were below detection for all trees and foliar Zn increased with increasing amount of both compost and high metal amendment, with concentrations of 249 mg kg-1 for trees grown in the compost amendment and 279 mg kg-1 for the high metal amendment. The results from this study indicate that the growth of A. rubra benefited from both types of biosolids used in the study

  2. Treatment Effect and Safety of Naftifine/ketoconazole Cream to Facial Pityriasis Versicolor in Children%萘替芬酮康唑乳膏治疗儿童面部花斑癣的疗效观察

    Institute of Scientific and Technical Information of China (English)

    李麟

    2014-01-01

    目的:观察萘替芬酮康唑乳膏治疗儿童面部花斑癣的疗效与安全。方法:将95例患儿随机分成治疗组和对照组,治疗组外用萘替芬酮康唑乳膏,对照组外用特比奈芬软膏,于治疗2、4周后观察疗效及有无不适反应,并根据真菌镜检结果判定疗效。结果:治疗组治疗2周时治愈率为90%,4周时治愈率为100%,不适反应率为10%;对照组治疗2周时治愈率为71%,4周时治愈率为84%,不适反应率为27%。两组有效率及安全性差异有统计学意义(P<0.05)。结论:萘替芬酮康唑乳膏治疗儿童面部花斑癣安全而有效。%Objective:To observe the clinical efficiency and safety in the treatment of facial pityriasis versicolor in children with Naftifine/Ketoconazole Cream. Methods:95 children patients were randomly divided into treatment group and control group. Naftifine/ketoconazole cream were applied in the treatment group, and Terbinafine were applied in the control group. The clinical efficiency and side effects were evaluated 2 and 4 weeks later, and therapeutic effect was determined according to the results of fungus infection.Results:At the end of 2 weeks and 4 weeks, the efficacy of the treatment group was 90%and 100%, while control group was 71%and 84%. The side effects of treatment group was 10%, and control group 27%. All of them had significant difference (P<0.05). Conclusion:Naftifine/ketoconazole cream is efficient and safe to treat facial pityriasis versicolor in the children.

  3. Pitiríase versicolor: isolamento e identificação das principais espécies de Malassezia Pityriasis versicolor: isolation and identification of the main species

    Directory of Open Access Journals (Sweden)

    Valéria Maria de Souza Framil

    2010-02-01

    Full Text Available As espécies do gênero Malassezia isoladas foram: Malassezia sympodialis (16,66%, Malassezia furfur (12,50%, Malassezia globosa (11,45% e Malassezia slooffiae (2,10%. A Malassezia sympodialis foi a espécie que predominou em nosso estudo. As espécies de Malassezia identificadas não mostraram correlação com as variantes clínicas e com a distribuição das lesões de pitiríase versicolor quanto às regiões do corpo.Species of the genus Malassezia isolated were: Malassezia sympodialis (16.66%, Malassezia furfur (12.50%, Malassezia globosa (11.45%, and Malassezia slooffiae (2.10%. Malassezia sympodialis predominated in the study. The species of Malassezia identified did not show correlation with clinical variants and with the distribution of pityriasis versicolor lesions in relation to areas of the body.

  4. γδ T-cell-rich variants of pityriasis lichenoides and lymphomatoid papulosis: benign cutaneous disorders to be distinguished from aggressive cutaneous γδ T-cell lymphomas.

    Science.gov (United States)

    Martinez-Escala, M E; Sidiropoulos, M; Deonizio, J; Gerami, P; Kadin, M E; Guitart, J

    2015-02-01

    T cells with a γδ phenotype have been associated with aggressive lymphomas. Yet, inflammatory skin disorders and low-grade lymphoproliferative disorders have rarely been described with a predominant γδ T-cell infiltrate. To review our experience and determine the clinical relevance of the γδ T-cell phenotype in lymphomatoid papulosis (LyP) and pityriasis lichenoides (PL). A retrospective dermatopathology file review looking for LyP and PL characterized by a γδ T-cell phenotype was performed. Clinical manifestations and course, histological features and molecular data were analyzed. Six of 16 cases of LyP and four of 23 cases diagnosed as PL during a 5-year period (2009-14) were identified. The median follow-up for the whole group was 16 months (range 3-64), showing an indolent clinical course in all cases. The detection of a predominantly γδ T-cell phenotype in papular lymphoid-rich infiltrates in the absence of other lesions is not associated with a clinically aggressive course. γδ T-cell-rich variants of LyP and PL may reflect a spectrum of related conditions. This is a single academic centre retrospective chart review of a relatively small sample. © 2014 British Association of Dermatologists.

  5. UV-B辐射胁迫下杨梅幼苗的高光谱响应%High-spectral responses of Myrica rubra seedlings to UV-B radiation stress

    Institute of Scientific and Technical Information of China (English)

    金鑫杰; 江洪; 陈健; 时启龙; 张倩倩

    2012-01-01

    A simulated field experiment with three treatments, i. e. , ambient light ( control) , reduced UV-B radiation, and enhanced UV-B radiation, was conducted to evaluate the effects of solar ultraviolet ( UV-B) radiation on the seedlings of Myrica rubra, a typical woody species in subtropical region. The leaf chlorophyll content, spectral reflectance and spectral characteristic parameters were measured and analyzed. As compared with the control, enhanced UV-B radiation decreased the seedling chlorophyll content while reduced UV-B radiation significantly increased the chlorophyll content, and these effects reflected in the spectral reflectance. Under the effects of the three gradients of UV-B radiation, the differences in the reflectance at visible region mainly occurred around the green peak and red edge on the reflectance curve, and the peak wavelength of the red edge shifted to longer wavelength. Enhanced UV-B radiation had an accumulated temporal effect on M. rubra. The inverted-Gaussian model parameters R0, λ0, λp, Rs, and 6 were the useful guides to reveal the spectral responses of M. rubra seedlings under UV-B radiation stress, among which, R8 performed the best. The differences in the spectral reflectance under different UV-B radiation levels could be effectively distinguished with the vegetation indices composed of the spectral reflectance of narrow wave bands or the reflectance at specific wavelengths.%设置UV-B滤光减弱、UV-B辐射增强和自然光(对照)3组模拟大田试验,比较了不同UV-B辐射处理下,亚热带典型木本植物杨梅幼苗的叶绿素含量、光谱反射率及光谱特征参数,研究UV-B辐射变化对亚热带森林树种的影响.结果表明:增强UV-B辐射可降低杨梅幼苗的叶绿素含量,而降低辐射则会显著促进叶绿素的增加,并且这种胁迫反应于光谱反射率中.3种不同梯度UV-B辐射作用下,可见光部分光谱反射率间的差异主要集中在绿光反射峰及红边附近,

  6. 基于BP神经网络的杨梅大棚内气温预测模型研究%Simulation and Forecast of Air Temperature inside the Greenhouse Planted Myica rubra Based on BP Neural Network

    Institute of Scientific and Technical Information of China (English)

    金志凤; 符国槐; 黄海静; 潘永地; 杨再强; 李仁忠

    2011-01-01

    利用2009年12月-2010年5月塑料大棚内外观测的气象数据,构建了基于BP神经网络的杨梅生产大棚内的最高、最低气温预测模型,根据逐时转化系数计算出棚内相应的逐时气温,达到逐时预报大棚内气温的目的.通过模拟回代和对独立试验数据的验证,基于BP神经网络模型对大棚内日最低气温、日最高气温和逐时气温预测值与实际值的回归估计标准误差(RMSE)分别为0.8℃、1.4C和0.7℃,精度明显高于同时利用逐步回归法建立的模型.该模型所需参数少,实用性强,模拟精度高,可为设施杨梅气象服务和环境调控提供依据.%The minimum and maximum temperature prediction model inside greenhouse planted Myica rubra was established based on BP neural network, by using meteorological data both inside and outside the greenhouse from December 2009 to June 2010 in Wenzhou of Zhejiang province. Using the independent experimental data and simulation back generations to verify the model,the results indicated that the root mean square error( RMSE) between the predicted value and measured value based on 1: 1 line for the minimum and maximum and hourly inside air temperature were 0. 8℃ ,1.4℃ and 0. 7℃ .respectively. The precision of BP neural network model was higher than that of the stepwise regression model obviously. The model,with few parameters,could predict the greenhouse temperature more accurately .which could provide scientific basis for facility meteorological service and environment regulation of greenhouse Myr-ica rubra cultivation.

  7. Gianotti-Crosti syndrome, pityriasis rosea, asymmetrical periflexural exanthem, unilateral mediothoracic exanthem, eruptive pseudoangiomatosis, and papular-purpuric gloves and socks syndrome: a brief review and arguments for diagnostic criteria

    Science.gov (United States)

    Chuh, Antonio; Zawar, Vijay; Law, Michelle; Sciallis, Gabriel

    2012-01-01

    Several exanthems including Gianotti-Crosti syndrome, pityriasis rosea, asymmetrical periflexural exanthem, eruptive pseudoangiomatosis, and papular-purpuric gloves and socks syndrome are suspected to be caused by viruses. These viruses are potentially dangerous. Gianotti-Crosti syndrome is related to hepatitis B virus infection which is the commonest cause of hepatocellular carcinoma, and Epstein-Barr virus infection which is related to nasopharyngeal carcinoma. Pityriasis rosea has been suspected to be related to human herpesvirus 7 and 8 infections, with the significance of the former still largely unknown, and the latter being a known cause of Kaposi's sarcoma. Papular-purpuric gloves and socks syndrome is significantly associated with human B19 erythrovirus infection which can lead to aplastic anemia in individuals with congenital hemoglobinopathies, and when transmitted to pregnant women, can cause spontaneous abortions and congenital anomalies. With viral DNA sequence detection technologies, false positive results are common. We can no longer apply Koch's postulates to establish cause-effect relationships. Biological properties of some viruses including lifelong latent infection, asymptomatic shedding, and endogenous reactivation render virological results on various body tissues difficult to interpret. We might not be able to confirm or refute viral causes for these rashes in the near future. Owing to the relatively small number of patients, virological and epidemiology studies, and treatment trials usually recruit few study and control subjects. This leads to low statistical powers and thus results have little clinical significance. Moreover, studies with few patients are less likely to be accepted by mainstream dermatology journals, leading to publication bias. Aggregation of data by meta-analyses on many studies each with a small number of patients can theoretically elevate the power of the results. Techniques are also in place to compensate for

  8. 从花斑糠疹皮损分离的马拉色菌随机扩增多态性DNA研究%Random amplified polymorphic DNA analysis of Malassezia isolates from cutaneous lesions of pityriasis versicolor

    Institute of Scientific and Technical Information of China (English)

    谢震; 冉玉平; 刘瑞; 杨如学; 李志瑜; 代亚玲

    2009-01-01

    目的 用随机扩增多态性DNA方法 研究分离自花斑糠疹的马拉色菌种间和株间差异,了解随机扩增多态性DNA分析(RAPD)与生理生化方法 在菌种分型上的差异及菌株DNA型别和菌种间的关系.方法 用氯化苄法提取马拉色菌标准株(10株7个种)和临床分离株(47株)的基因组DNA,其中临床株分离自34例花斑糠疹患者,经形态学和生理生化方法 鉴定为5个种(合轴马拉色菌、糠秕马拉色菌、钝形马拉色菌、球形马拉色菌、限制马拉色菌),用4种随机引物(S22、SS24、S25、S33)对菌株DNA做PCR随机扩增,NTSYS软件自动生成树状分支图.结果 绝大多数标本均可被4种引物扩增而获得清晰条带,其中2种引物(S22、S24)的条带更为稳定、清晰.共82条DNA片段被扩增,所有菌株均可见种间和株间多态性.有4例患者皮损同时分离出不同种的菌株显示遗传相似性高,在树状图中归入一类.结论 来自同一宿主的不同菌株遗传趋同现象提示马拉色菌的种特异性、菌种演化与宿主间存在密切关系.%Objective To investigate intraspecific and interspecific variation within Malassezia iso-lates from patients with pityriasis versicolor by random amplified polymorphic DNA (RAPD) analysis, to learn the difference between RAPD analysis and physiological and biochemical methods in the typing of Malassezia species, and to explore the relationship between RAPD patterns and Malassezia species. Methods A total of 47 Malassezia isolates were obtained from 34 patients with pityriasis versicolor, and they were classified into 5 species by morphological, physiological and biochemical features, I.e., M. Fin'fur, M. Obtusa, M. Globosa, M. Restricta and M. Sympodialis. Genomic DNA was extracted from the 47 clinical isolates and 10 reference strains (including 7 species) of Malassezia. PCR was performed using 4 random primers including S22, S24, S25 and S33. RAPD patterns were analyzed by NTSYS

  9. Efficacy and tolerability of a cream containing AR-GG27® (sorbityl furfural palmitate) in the treatment of mild/moderate childhood atopic dermatitis associated with pityriasis alba. A double-blind, placebo-controlled clinical trial.

    Science.gov (United States)

    Patrizi, A; Raone, B; Raboni, R; Neri, I

    2012-12-01

    Pityriasis alba (PA) is a skin disorder characterized by finely scaly, hypopigmented patches, typical of childhood, that also represents an atopic dermatitis (AD) minor sign according to Hanifin and Rajka criteria. It may be isolated or associated with AD representing, sometimes an atypical manifestation of AD during the long-term follow-up of the disease. Aim of the study was to evaluate of the efficacy and tolerability of AR-GG27® (sorbityl furfural palmitate) cream in the treatment of childhood mild or moderate AD associated with PA. The trial is a single center, double-blind, randomized, placebo-controlled study. The study included patients of both sexes, aged between two months and 15 years, suffering from mild and moderate AD always associated with PA. Xerosis was present in all patients. The treatment with topical steroids or topical calcineurin inhibitors (TIMs) had to be suspended for at least 15 days. Any systemic therapy and phototherapy or sun exposure were withdrawn at least 30 days before. Emollients were stopped at least seven days before. During the trial, no other local or systemic treatments were allowed, as well as sun exposure. Patients affected by AD with viral, bacterial or fungal overinfection or patients with diabetes mellitus, severe systemic diseases or intolerance to one or more components of the product were excluded. The primary endpoint was the evaluation of the average change in the Investigator Global Assessment (IGA) after 15 and 30 days of treatment. The second endpoint was the evaluation of severity of three different clinical signs: erythema, excoriation desquamation, using a subjective five-point scale. Changes in pruritus severity was also considered during the entire period of treatment, through the use of a Visual Analogue Scale (VAS). A Pskin conditions characterized by inflammation and tissue oxidative stress in children, as PA with mild and moderate AD.

  10. Nested PCR analysis for malassezia microflora from the scales of patients with pityriasis versicolor%花斑癣患者皮屑中马拉色菌的巢式PCR法分析

    Institute of Scientific and Technical Information of China (English)

    赵秀红; 冉玉平; 熊琳; 周光平; 山崎; 坪井良治; 小川秀兴

    2004-01-01

    目的用巢式PCR法检测马拉色菌特异的DNA从而快速准确的检测并鉴定马拉色菌的各菌种,并应用于花斑癣(Pityriasis Versicolor,PV)患者皮屑中马拉色菌携带情况中的研究.方法从PV患者的皮屑中提取马拉色菌的DNA,以马拉色菌属rRNA内转录间隔区设计属的引物和各个种的特异性引物分别进行巢式多聚酶链反应(nestPCR),检测105例PV患者皮屑中的马拉色菌的目的DNA片断.结果105例PV患者共检测到5例种的共321株马拉色菌的DNA.每例患者平均检测到约3种马拉色菌的DNA.各种马拉色菌的检出率依次为:球形马拉色菌80.0%,限制马拉色菌81.9%,合轴马拉色菌77.1%,糠秕马拉色菌41.9%,钝形马拉色菌15.2%.未检测到厚皮马拉色菌和斯洛菲马拉色菌.结论PV皮屑中存在多种马拉色菌,球形马拉色菌、合轴马拉色菌和限制马拉色菌是PV患者皮损处的主要马拉色菌种.

  11. 急性痘疮样糠疹合并结节性血管炎1例%A Case Report of Pityriasis Lichenoides Etvarioliformis Acuta And Nodular Vasculitis

    Institute of Scientific and Technical Information of China (English)

    雷微; 陈永艳; 袁伟; 黄洋

    2011-01-01

    患者女,26岁.全身丘疹3月,四肢结节伴疼痛10天.皮损为圆形丘疹,表面有鳞屑覆盖,周围绕以红晕,以四肢明显,部分丘疹中心萎缩凹陷;左前臂、双小腿伸侧散在红色皮下结节,有压痛感.组织病理示:①小腿丘疹:表皮内见基底细胞灶性液化变性,真皮浅层血管周围大量淋巴细胞、组织细胞浸润,可见血管外红细胞.②小腿结节:皮下脂肪组织内见一大血管破坏,周围脂肪小叶弥漫性炎细胞浸润.诊断:急性痘疮样糠疹合并结节性血管炎.%A26-year-old female presented with body pimples for three months, limbs nodules with tendemess for ten days. Lcsions are round papules to clear limbs, and which surface with scales, and around to flush, some papules center atrophy depression; the red subcutaneous nodule on the left forearm and shank with tenderness. After histopathological examination, the pathologic slice of the papules on her shank shows focal liquefaction degeneration of basal cell in the epidermis, a large number of lymphocytes and histocytes around the superficial dermal vessels. and some crythrocytes out of the vessel. The nodules of her shank pathologica slice shows the angiolysis in the subcutancous adipose tissue and the surrounding fat lobules with diffuse infiltration of inflammatory cells. Diagnosis: Pityriasis lichcnoides etvarioliformis acuta and nodular vaseulitis.

  12. Determination of Paeoniflorin in Total Saponins of Radix Paeoniae Rubra by TLC Scanning%双波长薄层扫描测定赤芍总甙中芍药甙含量

    Institute of Scientific and Technical Information of China (English)

    徐先祥; 刘青云; 俞能高; 葛少祥

    2001-01-01

    Objective: To study the preparing technology of total saponins ofRadix Paeoniae Rubra and its quality standards. Methods: Total saponins were extracted from Paeonia lactiflora Pall. by EtOH refluxing, EtO degreasing and n-BuOH extracts, the yield was more than 5%. The dual wavelength TLC-scanning was used to determine the content of paeoniflorin at 254 nm. Results: The average content of paeoniflorin in the extractive was 44.1%. Conclusion: The extracting method was simple, rapid and available.%目的:研究赤芍总甙的制备工艺和质量标准。方法:赤芍经乙醇回流,乙醚脂和正丁醇萃取得到赤芍总甙,得率>5%,所得赤芍总甙以双波长薄层扫描测定了芍药甙含量,测定波长λS=254nm。结果:样品中芍药甙含量平均为44.1%。结论:该提取方法简便、快速、可行。

  13. [The role of motivation in the performance of a conditioned switching-over of the maze habit in ants Myrmica rubra after a change in the quality of the food reinforcement].

    Science.gov (United States)

    Udalova, G P; Karas', A Ia

    2005-01-01

    Active foragers Myrmica rubra were trained in a maze under conditions of different levels of colony need in food with carbohydrate (sugar syrup) or protein (ants Lasius niger pupae) reinforcement. Acquisition of the maze habit was better under conditions of reinforcement with pupae, especially by its time indices. Ants were able to modify the acquired habit when the reinforcement quality was changed. It was shown that learning was possible only when the colony and after a change pupae for the syrup was "hungry". Under these conditions, after a change of the syrup for pupae or visa versa the previously acquired optimum habit was transferred. Several hours later, with satiation of the colony, food reactions learned with protein reinforcement switched-over to "stochastic" non-optimized behavior with the dominance of exploratory reactions. Thus, it was shown that higher social insects ants were capable for conditioned switching-over. Different forms of this phenomenon depended on the level of the colony need in food and, consequently, on the level of the social food motivation of foragers ants.

  14. 微柱高效液相色谱法测定杨梅黄酮类物质%The Determination of Myrica Rubra Flavonoid by Microcolumn High Performance Liquid Chromatography

    Institute of Scientific and Technical Information of China (English)

    胡秋芬; 杨亚玲; 黄章杰; 杨光宇; 尹家元

    2004-01-01

      经固相萃取预分离,由微柱高效液相色谱法测定了几种杨梅树叶和树皮中的黄酮类物质.杨梅中主要的黄酮成分在2.0min内可达到基线分离;用紫外二极管矩阵检测器检测.方法标准回收率为97%~103%,相对标准偏差为1.6%~2.2%.%  A microcolumn high performance liquid chromatography (HPLC) method for the determination of flavonoid in myrica rubra leaf and bark was studied. The flavonoid was separated on a Waters XterraTM RP18 (1.0´ 30mm, 2.5m m) chromatographic column, with methanol and 0.05mol/L potassium dihydrogen phosphate buffer solution as mobile phase at a flow-rate of 0.2mL/min, and monitored with the photodiode array detector at 360nm. The recoveries of the flavonoid are 97%~103%, and relative standard deviations are 1.6%~2.2%.

  15. Analysis on the triggering factors of pityriasis versicolor, Malassezia folliculitis and seborrheic dermatitis%花斑癣、马拉色菌毛囊炎、脂溢性皮炎马拉色菌诱发因素分析

    Institute of Scientific and Technical Information of China (English)

    许雪; 李红宾; 黄云丽; 李玉叶; 董天祥; 林松发; 程露

    2014-01-01

    Objective To investigate the triggering factors of pityriasis versicolor , Malassezia folliculitis and seb-orrheic dermatitis.Methods Survey among the patients with pityriasis versicolor, Malassezia folliculitis or seborrheic dermatitis was performed by questionnaire.Results Of the 158 patients, there were 104 males and 54 females, aged 29.4 years.The proportion of patients with hyperidrosis and oily skin is more than 60%.Systemic or topical applica-tion of corticosteroids was the main risk factor of Malassezia folliculitis.Conclusion Malassezia infection was com-mon in young adults.Pityriasis vesicolor was common in patient with hyperidrosis.The oily skin and application of corticosteroids were the main triggering factor of Malassezia folliculitis.%目的调查昆明地区花斑癣、马拉色菌毛囊炎、脂溢性皮炎马拉色菌诱发因素,并比较三种疾病的诱发因素有无差异。方法收集花斑癣、马拉色菌毛囊炎、脂溢性皮炎(头皮屑)的病例,用自制的调查表对入选病例进行诱发因素调查,比较诱发因素在三种疾病间有无差异。结果共收集158例病例,男104例,女54例,平均年龄29.4岁,多汗、油性皮肤患者所占比例均超过60%,系统或局部使用糖皮质激素是马拉色菌毛囊炎的危险因素。结论马拉色菌感染好发于男性青壮年,多汗者易发生花斑癣,油性皮肤及使用糖皮质激素易发生马拉色菌毛囊炎。

  16. 急性痘疮样苔藓样糠疹64例临床分析%Clinical analysis of 64 cases with pityriasis lichenoides et varioliformis acuta

    Institute of Scientific and Technical Information of China (English)

    封常霞; 韩娜娜; 周江峰; 李君

    2014-01-01

    目的:分析急性痘疮样苔藓样糠疹(PLEVA)临床特征和疗效。方法:对64例 PLEVA 患者进行回顾性分析。结果:(1)64例患者中男女发病率之比为4.3∶1;(2)29.69%的患者发病前有感染史,93.75%的患者皮损具有多形性,43.75%症状较重者出现白细胞计数、转氨酶、免疫球蛋白(IgM、IgG、IgA)等实验室检查指标异常;(3)组织病理:淋巴细胞性血管炎,淋巴细胞、红细胞游入表皮为特征;(4)糖皮质激素、窄波中波紫外线(NB-UVB)、雷公藤多苷、四环素、甘草酸二胺等联合治疗有效。结论: PLEVA 临床表现多样性,治疗以糖皮质激素为主。%Objective: To analyze the clinical features and treatment of pityriasis lichenoides et variolifor-mis acuta (PLEVA). Methods: We retrospectively analyzed the clinical and laboratory data of 64 patients di-agnosed as PLEVA. Results: (1) The ratio between male and female was 4.3 ∶1. (2) 29.69% of the patients had an infection history before the onset of the disease. Pleomorphic skin lesions, such as erythema, papules, necrosis, ulceration, et al were seen in 93.75% of the patients. The abnormal laboratory tests such as white blood cell count, aminotransferase, immunoglobulin (IgM, IgG, IgA) were seen in 43.75% of severe pa-tients. (3) The pathological examination showed lymphocytic vasculitis, migration of lymphocytes and erythro-cytes into the epidermis. (4) The treatments including glucocorticoids, NB-UVB, TWP, tetracycline and gly-cyrrhizin diamine were effective. In severe PLEVA (39.06%) glucocoriticoid had been used in a combination with other drugs. Conclusion: PLEVA has a variety of clinical manifestations and steroid is till the mainstay in the treatment.

  17. 灯盏细辛与赤芍配伍对永久性脑缺血损伤大鼠的保护作用%Compatibility of erigeron breviscapus and radix paeoniae rubra protects rats against cerebral ischemic injury

    Institute of Scientific and Technical Information of China (English)

    范娅丹; 韩江全; 邓才洪

    2016-01-01

    目的:探讨灯盏细辛与赤芍配伍药对脑缺血性损伤大鼠的保护作用及可能机制。方法方法48只成年SD雄性大鼠随机分为4组:假手术组、脑缺血组、配伍药物治疗组、阻滞剂组,每组12只。采用线栓法制作大脑中动脉闭塞模型。于缺血后24 h后行神经功能缺损评分,断头取脑行TTC染色检测脑梗死面积,实时荧光定量PCR法、蛋白质免疫印记法测缺血区脑皮质SHH、Patched-1、Gli-1mRNA及蛋白的表达。结果配伍药物组缺损评分、脑组织梗死面积显著低于脑缺血组和阻滞剂组。脑组织shh、Patched-1、Gli-1 mRNA及蛋白表达量显著高于脑缺血组,阻滞剂组Gli-1mRNA及蛋白表达量显著低于配伍药物组。结论灯盏乙素与芍药苷配伍对大鼠局灶性脑缺血损伤具有一定的保护作用,其机制与上调Sonic Hedgehog ( Shh)通路关键蛋白分子表达量有关。%Objective To investigate the protective effect of the compatibility of Erigeron breviscapus and Radix Paeoniae Rubra on cerebral ischemia injury rats and its possible mechanisms .Methods Forty-eight adult male Sprague-Dawley rats were divided into four groups randomly:a sham operation group ,a cerebral ischemia group ,a treatment group and an inhibitor group,12 in each group.MCAO model was performed according to Zea-longa’s report.Neurological deficit scores were performed after 24 h of the operation .Then decapitated the rats and took out their brain .Detected infarct size by 2,3,5-triphenyltetrazolium chloride (TTC) staining,and detected the expression of the mRNA levels of Shh、Patched-1、Gli-1 by RT-PCR and assessed the proteins expression of them by Western blotting .Results The neurological deficit score and the infarct size in the treatment group were lower than that in the cerebral ischemia and inhibitors groups ,both of the differences were statistically significant .RT-PCR and Western blotting suggested that the mRNA and

  18. 杨梅树叶、皮、根部精油成分及其抗氧化活性物质%Chemical Composition and Antioxidant Components of Essential Oils from Leaves, Bark and Root of Myrica rubra

    Institute of Scientific and Technical Information of China (English)

    钟瑞敏; 张振明; 王羽梅; 曾庆孝; 彭华贵

    2006-01-01

    采用GC-MS技术结合Kovats保留指数(KI)对比法分析鉴定了采自南岭自然保护区的乌杨梅(Myrica rubra var.astropurea Tsen.)叶、皮和根部芳香精油的成分,同时运用薄层层析(TLC)筛分法对其抗氧化活性物质进行了对比分析.杨梅树根和树皮精油的主要成分为5-羟基菖蒲烯(相对含量分别为74.66%和60.32%)和油酸(7.74%和11.39%),而树叶精油的主体成分为5-羟基菖蒲烯(30.44%)、石竹烯(11.61%)、异石竹烯(10.17%)、(E)-橙花叔醇(9.57%)和油酸(4.40%).树根、树皮到树叶部位的次生代谢物明显出现越来越复杂的分化特性.5-羟基菖蒲烯是3个部位精油的主要抗氧化活性物质,但叶部精油中的倍半萜烯类物质也表现出一定的二苯代苦味酰(DPPH)自由基清除活性.

  19. Approach to the study of C-glycosyl flavones acylated with aliphatic and aromatic acids from Spergularia rubra by high-performance liquid chromatography-photodiode array detection/electrospray ionization multi-stage mass spectrometry.

    Science.gov (United States)

    Ferreres, Federico; Gil-Izquierdo, Angel; Vinholes, Juliana; Grosso, Clara; Valentão, Patrícia; Andrade, Paula B

    2011-03-30

    The use of mass spectrometry (MS) coupled to liquid chromatography (LC) as working tool for the study of the C-glycosyl flavones acylated with aliphatic and aromatic acids has allowed the tentative characterization of these compounds in Spergularia rubra and the establishment of the position of the acylation on the sugar moiety of the C-glycosylation by use of MS data. The combination of retention time (Rt), ultraviolet (UV) and MS(n) data of the compounds revealed their C-glycosyl flavone nature, being luteolin, apigenin and chrysoeriol derivatives. Ten non-acylated flavones were identified, from which six are described for the first time (one 7-O-glycosyl-6,8-diC-glycosyl flavone, four 6,8-diC-glycosyl flavones and one 2"-O-glycosyl-6-C-glycosyl flavone). Twenty-six acylated derivatives were also found for the first time. These compounds are grouped in three classes, namely, C-glycosyl flavones acylated with aliphatic acids, with aromatic acids or with a mixed acylation. The first group is characterized by the presence of one 6,8-diC-(acetyl)glycosyl flavone, four 6,8-diC-(malonyl)glycosyl flavones and two 7-O-glycosyl-6,8-diC-(malonyl)glycosyl flavones, while in the second one twelve 6,8-diC-(acyl)glycosyl flavones and two 7-O-glycosyl-6,8-diC-(acyl)glycosyl flavones are described. The last class contained five 6,8-diC-(malonyl,acyl)glycosyl flavones. No previous work has described the presence of C-glycosyl flavones acylated with aliphatic acids in this genus.

  20. Study on Growth Characteristics of Myrica rubra after Grafting and Transformation%乡土杨梅嫁接改造成活后的生长特性调查

    Institute of Scientific and Technical Information of China (English)

    刘英杰; 王齐; 段文学; 王亚丽

    2011-01-01

    The growth characteristics of 3 -year indigenous Myrica rubra after grafting and transformation was investigated, the results showed that using different kind of local bayberry as rootstock, the growth rate of grafting branch, crown width were different. To Myrica esculenta, the relationship change between its scion base-diameter and the growth of grafting branch, crown width were represented with exponential regression, when scion base-diameter was 5. 1 ~ 6. Ocm, the amplification of crown width was increasing fast. To Myrica nana cheval, the relationship between its scion base-diameter and the growth of grafting branch, crown width were represented with linear regression, and with the increasing of scion base-diameter, the growth of grafting branch, crown width were also increased.%对嫁接改造后3 a生植株的生长进行调查,结果表明,采用不同乡土杨梅树种作砧木嫁接,成活后嫁接枝长、冠幅生长速率不同.大树杨梅其接穗基径与嫁接枝长、冠幅生长呈指数函数关系变化,接穗基径为5.1~6.0 cm时,树冠的增幅较快;矮杨梅其接穗基径与嫁接枝长、冠幅生长之间都呈线性关系变化,随接穗基径的增大,嫁接枝长、冠幅生长也随之增大.

  1. 赤芍二基源药材的HPLC指纹图谱鉴别及质量评价%Species Differentiation and Quality Assessment of Radix Paeoniae Rubra from Paeonia lactiflora and Paeonia veitchii by Means of HPLC Fingerprint

    Institute of Scientific and Technical Information of China (English)

    向楚兵; 刘友平; 陈鸿平; 陈林; 杨昌林

    2011-01-01

    目的:通过HPLC指纹图谱研究,快速有效鉴别北赤芍与川赤芍,并评价其质量.方法:采用高效液相色谱法,分别以北赤芍与川赤芍对照药材为参照图谱,对不同产地、不同采收期的12批北赤芍与29批川赤芍进行指纹图谱研究,同时对其进行相似度评价,并采用判别分析,建立北赤芍与川赤芍的Fisher线性判别函数.结果:北赤芍对照药材与川赤芍对照药材的相似度约为0 7,<0 9,12批北赤芍与29批川赤芍与其相应对照药材的相似度都在0 9以上;北赤芍与川赤芍的Fisher线性判别函数为:Y北赤芍=139.797X1+21.961X2+30.927X3-14.796,Y川赤芍=45.688X1-10.867X2+ 69.898X3-13.440(自变量X1,X2,X3分别表示以芍药苷为参照峰的儿茶素、芍药内酯苷及苯甲酸的相对峰面积).结论:采用HPLC指纹图谱,结合相似度评价或判别分析,可快速、有效鉴别北赤芍与川赤芍.川赤芍与北赤芍的化学成分既有共性,又存在差异,且川赤芍更复杂.物种来源不同是导致二者化学成分存在差异的主要因素,而产地及采收期对其影响不大,故应当根据上述研究并结合相关实验,制定规范的赤芍二基原药材质量标准,指导临床安全有效用药.%Objective:To quickly and effectively discriminate Radix Paeoniae Rubra originates from Paeonia lactiflora and Paeonia veitchii, and evaluate the quality of them by HPLC fingerprint. Method: HPLC fingerprint was adopted to analyze 12 batches of P. Lactiflora and 29 batches of P. Veitchii that from different fields and picking time,and setting the profile of reference crude drug of P. Lactiflora and P. Veitchii Lynch as a control. The similarity was evaluated according to the software- Herb Fingerprint Similarity Assessment System' (2004A) , and established Fisher' s linear discriminant functions were astablished by discriminant analysis. Result; The similarity index of reference crude drug of P. Lactiflora and P. Veitchii is about

  2. Expression and significance of FOXP3 in pityriasis rosea, lichen planus, large-plaque parapsoriasis and mycosis fungoides%FOXP3在玫瑰糠疹、扁平苔藓、大斑块型副银屑病及蕈样肉芽肿中的表达及意义

    Institute of Scientific and Technical Information of China (English)

    周秉侠; 郭淑兰; 许艳静

    2012-01-01

    Objective To investigate expression and significance of fork-head box protein-3 (FOXP3) in normal skins, pityriasis rosea, lichen planus, large-plaque parapsoriasis, and mycosis fungoides. Methods The immunohistochemi-cal EnVision method was applied to detect expression of FOXP3 in 21 cases of pityriasis rosea, 19 cases of lichen planus , 17 cases of large-plaque parapsoriasis, 22 cases of mycosis fungoides, and 10 normal skin controls. Results Rates of FOXP3 -positive lymphocytes in lesions of pityriasis rosea and lichen planus had no significant difference compared with normal skin (P >0.05). Rates of FOXP3-positive lymphocytes in lesions of large-plaque parapsoriasis and mycosis fungoides were higher than those in pityriasis rosea, lichen planus, and normal skin(P 0. 05). Conclusions FOXP3-positive lymphocytes show a gradual increasing tendency in inflammatory skin diseases, tumor tendency inflammatory skin diseases and cutaneous lymphoma. They may play an important role in immune escape of tumors and promote tumor occurrence and development.%目的 探讨叉头状转录因子P3( FOXP3)在玫瑰糠疹、扁平苔藓、大斑块型副银屑病及蕈样肉芽肿中的表达及意义.方法 采用免疫组织化学EnVision法检测21例玫瑰糠疹、19例扁平苔藓、17例大斑块型副银屑病、22例蕈样肉芽肿及10例正常人皮肤中FOXP3的表达.结果 玫瑰糠疹、扁平苔藓皮损中FOXP3+淋巴细胞阳性率与正常人皮肤中的表达差异无统计学意义(P>0.05);大斑块型副银屑病与蕈样肉芽肿皮损中FOXP3+淋巴细胞阳性率均高于玫瑰糠疹、扁平苔藓及正常皮肤(P<0.05),但其二者之间的表达差异无统计学意义(P>0.05).结论 FOXP3+淋巴细胞阳性率在炎症性皮肤病、有肿瘤发展倾向的炎症性皮肤病及皮肤淋巴瘤中的表达有逐步增高的趋势.其增多可能为肿瘤细胞的免疫逃逸提供了条件,进而促进了肿瘤的发生、发展.

  3. Identification of the Antibacterial Activity ofMorus rubra Leaves by a High- Throughput Screening Method%以高通量方法筛选红桑叶的抗菌活性并进行活性组分的分离研究

    Institute of Scientific and Technical Information of China (English)

    周英; 黄赤夫

    2007-01-01

    目的 通过一种简单快速的高通量方法筛选具有抗菌活性的植物提取物,并通过此种方法从有活性的粗提物中纯化活性组分.方法 首先建立植物提取物库和抗菌的高通量筛选方法.然后针对转糖链球菌Streptococcus mutans和伴放线放线杆菌Actinobacillus actinomycetemcomitans进行高通量筛选.结果 通过筛选发现红桑叶具有很强的抑菌活性.为了进一步研究其活性,将其粗提物通过HPLC进行分离得到71个组分,再通过同样的高通量筛选方法进行抗菌活性测定,对有活性的组分通过血琼脂法进行验证.实验数据表明红桑叶的一个组分#31对两种细菌有几乎完全的抑制(抑制率>99%),而另外两个组分对伴放线放线杆菌Actinobacillus actinomycetemcomitans有部分抑制.结论 所建立的高通量筛选方法简便快捷,筛选结果稳定可靠,可用于大规模的植物提取物的抗菌活性筛选.红桑叶具有很强的抗菌活性,且可分离得到活性组分,红桑叶具有进一步开发为抗菌药物和保健品的潜力.%Objective This research intended to test the antibacterial activity of a plant extract library using a simple and fast colorimetric detection method and identify those plant extracts with bioactivity, and to further purify those bioactive fractions of the selected plant extracts. Methods We first created a plant extract library and developed an antimicrobial High Throughput Screening (HTS) method. Then, the plant extracts were tested for antibacterial activity against two species of bacteria, S. mutans and A. actinomycestemcomitans. Results The Morus rubra leaf extract was selected because it had the strongest biological activity against the oral bacteria tested. To further study the Morus rubra leaves, the extract was separated into small fractions via high -performance liquid chromatography (HPLC). The fractions were tested against bacteria S. mutans and A. actinomycestemcomitans using HTS

  4. Pitiriasis liquenoide: estudio retrospectivo clínico epidemiológico de 49 pacientes pediátricos Pityriasis lichenoides: a retrospective clinical and epidemiological study of 49 pediatric patients

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    GP Sciancalepore

    Full Text Available La pitiriasis liquenoide (PL, entidad pápulo-escamosa, afecta principalmente a niños. Presenta una forma aguda, "pitiriasis liquenoide y varioliforme aguda" (PLEVA y otra crónica, la pitiriasis liquenoide crónica (PLC. Objetivo: describir las características de pacientes con diagnóstico clínico e histopatológico de PL. Comparar nuestros resultados con los hallados en la bibliografía. Materiales y Métodos: historias clínicas e informes anátomo-patológicos de 49 pacientes que consultaron entre marzo de 2000 a marzo de 2011. Se analizaron los datos obtenidos mediante el programa SPSS 11.5. Resultados: de 49 pacientes con PL, 17 presentaron PLEVA y 32 PLC. El promedio de edad de inicio de PLEVA fue de 6 años y de 10 años para PLC. Predominó el sexo masculino en PLEVA. Las formas generalizadas parecieran ser las predominantes. Las lesiones más frecuentemente halladas fueron: pápulas y pápulas eritematosas en PLEVA, escamas en PLC y las máculas hipocrómicas como discromía residual. 14 de 49 pacientes mostraron asociaciones mórbidas. Conclusiones: la PL puede ser dividida en aguda y crónica, a pesar de existir ambas clases de lesiones en un mismo paciente. PLEVA se presentó a edades más tempranas, predominando en varones. De los pacientes que presentaron co-morbilidades, la mayoría comprometía la inmunidad.Background: the pityriasis lichenoides (PL, a papulosquamous disease, affects mostly children. Present an acute form, pytiriasis lichenoides et varioliformis acute (PLEVA and other chronic, chronic lichenoid pytiriasis (PLC. Objetive: to describe the caracheristics of patients with clinic and histopathological diagnosis of PL. Compare our results with those found in the literature. Materials and Methods: clinical records and pathology reports of 49 patients who consulted between March 2000 and March 2011. Data were analyzed using SPSS 11.5. Results: of 49 patients with PL, 17 presented PLEVA and 32 PLC. The average age of

  5. 花斑糠疹和马拉色菌毛囊炎致病菌菌种分析%Study the Pathogenic Species of Pityriasis Versicolor and Malassezia Folliculitis

    Institute of Scientific and Technical Information of China (English)

    耿承芳; 占萍; 陶丽; 李智华; 江清; 金云; 罗云鹏

    2011-01-01

    目的 使用限制性内切酶方法鉴定临床花斑糠疹和马拉色菌毛囊炎致病菌菌种分布并比较其差异.方法 收集临床花斑糠疹和马拉色菌毛囊炎标本,植于Leeming-Notman培养基.培养阳性菌株提取DNA,扩增其26srDNA片段,用Cfo Ⅰ酶和BstF51酶切.结果 共鉴定花斑糠疹阳性菌株128份,其中糠秕马拉色菌49份,合轴马拉色菌23份,球形马拉色菌26份,钝性马拉色菌6份,M.japponica 1份,斯洛菲马拉色菌1份,混合感染标本22份.共鉴定马拉色菌毛囊炎阳性标本70份,其中糠秕马拉色菌43株,合轴马拉色菌5株,球形马拉色菌9株,钝性马拉色菌1株,混合感染标本12份.两种疾病菌种分布差异存在统计学意义(P=0.009).结论 花斑糠疹和马拉色菌毛囊炎致病菌菌种存在一定差异.限制性酶切方法为一种准确、快速的马拉色菌菌种鉴定方法.%Objective To investigate the pathogenic species in patients of Pityriasis versicolor (PV) and Malassezia folliculitis(MF). Methods Clinical specimens from PV and MF patients were collected and cultured onto Leeming-Notman medium. DNA was extracted from positve cultures followed by the polymerase chain reaction-restriction fragment length polymorphism with 2 restriction enzymes, CfoI and BstF51. Results One hundred and twenty-eight cultures from PV were identified with 49 strains of M. furfur, 23 M. sympodialis,26 M. globosa, 6 M. obtuse, 1 M. japonica, 1 M. slooffiae and 22 mixed infections, respectively. Seventy cultures from MF were identified with 43 strains of M. furfur, 5M. sympodialis, 29 M. globosa, 1 M. obtuse,12 mixed infections, respectively. The distribution of malassezia species was significantly different between the two groups (P =0. 009) . Conclusion The pathogenic Malassezia flora show different between PV and MF. The polymerase chain reaction-restriction fragment length polymorphism is an accurate and quick method to identify clinical Malassezia species.

  6. 急性痘疮样苔藓样糠疹28例临床分析%Clinical Analysis on 28 Cases of Pityriasis Lichenoides et Varioliformis Acuta

    Institute of Scientific and Technical Information of China (English)

    黄莉宁; 罗光浦; 薛汝增; 谷梅; 刘红芳; 吴铁强; 陈永锋; 顾有守; 杨斌

    2014-01-01

    目的:分析急性痘疮样苔藓样糠疹患者的临床特点及治疗方法。方法:回顾性分析28例急性痘疮样苔藓样糠疹患者的临床资料。结果:28例患者中男18例、女10例,平均年龄(23.9±6.25)岁。10~20岁为好发年龄段(13例)。病程15天至24个月不等。皮损主要表现为出血坏死性丘疹和痘疮样疤痕,主要分布于躯干及四肢,面部、掌跖部位少见。组织病理见坏死角质形成细胞、基底细胞液化变性、真皮内淋巴细胞大致呈楔形浸润。主要治疗方案为口服四环素或红霉素,必要时加雷公藤;病情严重者可静滴甲氨蝶呤。外用药物选择中强效糖皮质激素药膏或卡泊三醇。物理治疗选择补骨脂素光化学疗法(PUVA)或者窄谱中波紫外线。大部分患者按照上述方案组合治疗2~3周后,病情得到控制,皮损数量逐渐减少甚至消失,留有萎缩性疤痕。结论:急性痘疮样苔藓样糠疹的诊断需要临床与病理密切结合,合理的治疗方案可缩短病程。%Objective:To explore the clinical features and treatment of pityriasis lichenoides et varioliformis acuta ( PLEVA) .Methods:Retrospective analysis was performed on the clinical data of 28 patients with PLEVA .Results:The mean age of 28 patients (18 males and 10 females) was 23.9 ±6.25 years with a peak of 10 to 20 years.The clinical course was from 15 days to 24 months.The clinical features of PLEVA were hemorrhagic necrotic papules and varioliform scars . In lesion distribution , the majority of lesions were located on the trunk and limbs .The histopatho-logical features include apoptotic keratinocytes , liquefaction of basal cells , top-heavy and wedge-shaped lymphocyte infiltration .Oral tetracycline or erythromycin is the most effective treatment regimens.If necessary tripterygium wilfordii and methotrexate could be added .Topical corticoste-roids, topical calcipotriol , PUVA ( psoralen

  7. Clinicopathologic analysis of 60 cases of pityriasis lichenoides et varioliformis acuta%急性痘疮样苔藓样糠疹60例临床病理分析

    Institute of Scientific and Technical Information of China (English)

    徐秀莲; 王光平; 陈浩; 姜祎群; 曾学思; 贾虹; 孙建方

    2015-01-01

    目的 探讨急性痘疮样苔藓样糠疹(PLEVA)的临床病理特征.方法 回顾分析60例PLEVA患者的临床和病理资料.结果 60例PLEVA患者中,2~18岁32例(53.3%),19 ~ 49岁28例(46.7%).皮损分布情况:弥漫型50例(83.3%),中心型2例(3.3%),外周型8例(13.4%).发病前有上呼吸道感染史19例(31.6%).组织病理学检查:60例均具有基底细胞液化变性和真皮内血管周围炎改变.角质层内中性粒细胞脓肿26例(43.3%),表皮内坏死角质形成细胞41例(68.3%),发生广泛液化变性30例(50.0%),有淋巴细胞移入表皮43例(71.6%),有Pautrier微脓肿形成者2例,有程度不等的真皮浅层红细胞外溢者46例(76.7%),真皮内有血管壁纤维素样坏死者3例,演变为蕈样肉芽肿1例.20例患者行免疫组化检查,其中3例示T细胞单克隆性增生.结论 PLEVA临床表现有特征性,临床与病理的密切结合是诊断该病的金标准.%Objective To explore the clinicopathologic features of pityriasis lichenoides et varioliformis acuta (PLEVA).Methods A retrospective analysis was performed.Clinical and histological data were collected from 60 patients with PLEVA.The clinicopathologic features of PLEVA were analyzed.Results Among the 60 patients with PLEVA,32 (53.3%) were aged 2-18 years,and 28 (46.7%) aged 19-49 years.Skin lesions were distributed in a diffuse pattern in 50 (83.3%) patients,in a central pattern in 2 (3.3%) patients,and in a peripheral pattern in 8 (13.4%) patients.Nineteen (31.6%) patients had a history of upper respiratory infection.Histopathological examination revealed liquefactive degeneration of basal cells and perivasculitis in the dermis in all the 60 cases,neutrophil abscess formation in the stratum corneum in 26 (43.3%) cases,keratinocyte necrosis in the epidermis in 41 (68.3%) cases,generalized liquefactive degeneration in 30 (50.0%) cases,migration of lymphocytes into the epidermis in 43 (71.6%) cases

  8. PITYRIASIS LICHENOIDES CHRONICA IN A CHILD

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    Iolanda C. Fernandes

    2017-01-01

    Discussion: In general, the typical cutaneous lesions of PLC are asymptomatic and consist of erythematous papules with a central micaceous scale that can easily be detached to reveal a shiny surface (lichenoid. It usually resolves spontaneously following a long period of remissions and recurrences. The treatment options include topical and oral corticosteroids, oral erythromycin and heliotherapy, among others.

  9. Dermatite esfoliativa: estudo clínico-etiológico de 58 casos Exfoliative dermatitis: clinical and etiologic study of 58 cases

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    Rogério Nabor Kondo

    2006-06-01

    exfoliative dermatitis seen at the Hospital Universitário Regional do Norte do Paraná were reviewed over a ten-year period. RESULTS - A total of 58 patients with diagnosis of exfoliative dermatitis was assessed. Mean age was 56.89 years. The underlying disorder in 33 patients was a skin disease (psoriasis, 11 cases; contact dermatitis, 9 cases; congenital ichthyosiform erythroderma, 3 cases; seborrheic dermatitis, 5 cases; atopic dermatitis, 3 cases; pityriasis rubra pilaris, 2 cases. Drug reactions were observed in 11 patients. Etiology could not be determined in 14 cases (24%. CONCLUSIONS - In a sample of patients attending a reference dermatology center, exfoliative dermatitis was a rare condition, and in most cases it was related to skin diseases.

  10. Therapeutic effect of desloratadine citrate disodium tablets combined with narrow band ultraviolet B in the treatment of pityriasis rosea%枸地氯雷他定联合窄谱中波紫外线治疗玫瑰糠疹疗效观察

    Institute of Scientific and Technical Information of China (English)

    闫锐; 徐爱国; 黄晨

    2015-01-01

    Objective To observe the clinical efficacy of desloratadine citrate disodium tablets combined with narrow band ultraviolet B in the treatment of pityriasis rosea.Methods According to the digital table,88 pityriasis rosea patients were randomly divided into the two groups.45 cases of the study group were treated by desloratadine citrate disodium tablets combined with narrow ultraviolet B,43 cases of the control group were treated by desloratadine citrate disodium tablets alone.The both two groups applied Binghuangfule cream.The therapeutic effect and safety of the two groups were compared.Results The cure rate in study group was 71.11%,which of the control group was 51.16%,the difference was not statistically significant (x2 =3.69,P > 0.05).The effective rate of the treatment group was 91.11%,which of the control group was 69.77%,the difference between the two groups was statistically significant (x2 =6.43,P < 0.05).Conclusion The result reveals that desloratadine citrate disodium tablets combined with narrow band ultraviolet B is more effective and worthy to be used in clinical practice.%目的 观察枸地氯雷他定口服联合窄谱中波紫外线(NB-UVB)照射治疗玫瑰糠疹的疗效.方法 选择88例玫瑰糠疹患者,采用随机数字表法分为两组.治疗组45例采用口服枸地氯雷他定联合NB-UVB照射,对照组43例口服枸地氯雷他定,两组均外用冰黄肤乐软膏.观察两组的治疗效果和安全性.结果 治疗组痊愈率71.11%,有效率91.11%;对照组痊愈率51.16%,有效率69.77%,治疗组痊愈率优于对照组,但差异无统计学意义(x2=3.69,P>0.05);两组有效率差异有统计学意义(x2 =6.43,P<0.05).结论 枸地氯雷他定联合NB-UVB照射治疗玫瑰糠疹安全有效,值得临床推广应用.

  11. Study on Chemical Fingerprints of Traditional Chinese Medicine Radix Paeoniae Rubra in Oscillation System%不同产地中药赤芍在振荡体系中的化学指纹图谱研究

    Institute of Scientific and Technical Information of China (English)

    程旺兴; 管艺; 陈佳; 方成武

    2011-01-01

    采用H2 SO4 - CH2 (COOH)2 - Ce2( SO4)3- KBrO3化学振荡体系,研究了中药赤芍的化学指纹图谱,并对温度、赤芍用量进行了考察,确定体系的最佳实验条件为12 mL 3.0 mol/L H2SO4溶液、6 mL 0.4 mol/LCH2( COOH)2溶液、3 mL 0.005 mol/L Ce2( SO4)3和3 mL 0.2 mol/L KBrO3溶液,温度35℃、加入0.4g的中药材粉末.通过对不同产地中药材赤芍(安徽毫州、山东菏泽、内蒙古赤峰、海拉尔)化学指纹图谱的研究,发现不同产地的中药材赤芍不仅具有明显不同的化学指纹图谱形状,而且主要参数也有很大区别.其中毫州赤芍的最高诱导时间较小(133.76 s),但振荡寿命最长(554.89 8);而海拉尔赤芍的诱导时间最长(214.t7 s),但振荡寿命最短(237.11 s).该化学指纹图谱可方便地用于不同产地中药材赤芍的区别和鉴定.%Chemical fingerprints of Radix Paeoniae Rubra( RPR) from different places of origin were studied by chemical oscillation system of H2SO4 - CH2 (COOH) 2 - Ce2 (SO4) 3 - KBrO3. Effects of various variables on the chemical oscillation system were studied. The optimal conditions were as fol lows; 12 mL 3. 0 mol/L sulfuric acid, 6 mL 0. 4 mol/L malonate, 3 mL 0. 005 mol/L cerium am monium sulfate, 3 mL 0. 2 mol/L sodium bromate and 0. 4 g RPR powder at 35 ℃. The results indi cated that, under the optimal conditions, the chemical fingerprints of RPR from different places of origin( Bozhou, Heze, Chifeng and Hailaer) showed significantly different characteristics, such as the maximum potential, induction time and oscillation lifetime, etc. The results also indicated that the RPR from Bozhou had the shortest induction time( 133. 76 s) , but the longest oscillation lifetime (554. 89 s). The RPR from Hailaer had the longest induction time(214. 17 s) , but the shortest os cillation lifetime(only 237. 11 s). The chemical fingerprints could be used to identify the origins of RPR. The method is simple, rapid and sensitive, and without

  12. 模拟酸雨胁迫对杨梅幼苗水分生理特性的影响%Effects of simulated acid rain on water physiological characteristics of Myrica rubra seed lings.

    Institute of Scientific and Technical Information of China (English)

    姚兆斌; 江洪; 余树全; 鲁美娟

    2011-01-01

    选择浙江省典型亚热带经济植物杨梅为对象,通过盆栽试验研究了重度酸雨( pH2.5)、中度酸雨(pH 4.0)和对照(pH 5.6)处理对杨梅幼苗水分生理特性的影响.结果表明:季节、年份和酸雨对杨梅幼苗的光合速率均有显著影响,各处理中,夏季的差异大于春、秋季,pH 4.0处理对光合速率有促进作用;季节、年份、酸雨,季节-年份交互作用以及三者交互作用对气孔导度均有显著影响,各处理在夏季的差异大于春、秋季,酸雨对气孔导度有抑制作用;季节、年份、酸雨及季节-年份和季节-酸雨两两交互作用对蒸腾速率有显著影响,各处理夏季的差异大干春秋季,且pH2.5处理对蒸腾速率的抑制作用最强;酸雨、季节-年份和季节-酸雨交互作用对水分利用率有显著影响,且pH2.5处理对水分利用率有一定的促进作用.%Taking the seedlings of typical subtropical economic tree species Myrica rubra in Zhe-jiang Province as test materials, a pot experiment was conducted to study their water physiological characteristics under effects of simulated acid rain (pH 2. 5 and pH 4. 0), with water ( pH 5. 6) as the control. Season, year, and acid rain all had significant effects on the photosynthetic rate (Pn). Among the treatments, the Pn had a greater difference in summer than in spring and autumn, and was higher in treatment acid rain (pH 4. 0). Season, year, acid rain, and the interactions of season and year and of the three factors had significant effects on the stomata conductance (G,), and also, the G, had a greater difference among the treatments in summer than in spring and autumn. Acid rain had inhibitory effect on G,. Season, year, acid rain, and the interactions of season and year and of season and acid rain affected the transpiration rate (TT) significantly. Same as Pn and Gs, the Tt had a greater difference among the treatments in summer than in spring and autumn. Acid rain (pH 2. 5) had

  13. 多效唑对杨梅枯枝病的影响及防治%Effect of paclobutrazol (PP333) on twig dieback of Myrica rubra and control

    Institute of Scientific and Technical Information of China (English)

    陈方永; 倪海枝; 王引; 任正初; 刘继红; 王一光

    2014-01-01

    Summary Red bayberry ( Myrica rubra ( Lour .) Zucc) is one of the major fruits planted in Zhejiang Province , China . It provides an important financial support for the farmers in this area . However , the fungal disease twig dieback severely threats the growth of red bayberry . Once one plant is infected by this disease , it would spread and destroy the whole orchard in three years . Controlling technology on this disease is urgently needed at this area .Paclobutrazol ( PP333 ) is a chemical widely used for plant growth regulation . It causes plant growth shorter , stronger , more branches and better fruiting . It has been widely used on the red bayberry for higher production . However , over‐dosage use of the chemical PP333 is suspected to connect with the epidemic of twig dieback in Zhejiang , China . The causal agent of the twig dieback disease was proved to be Pestalotiopsis species . It is postulated that the application of PP333 inhibits some bacteria growth and breaks microbial community balance in the soil , so that the causal agent of twig dieback is predominant .In order to test the hypothesis , we investigated the correlation between application amount of PP 333 and disease severity in eight farms in Zhejiang in four years . In the eight farms , we investigated the connection of application dosage of PP333 with the residues of the chemical in leaves , roots and fruits respectively . In different treatments of PP333 , leaf colour , root architecture and fruit quality were also investigated . Application of three concentrations of PP333 , T1 (200 mg/kg) , T2 (300 mg/kg) and T 3 ( 500 mg/kg) , resulted in light , moderate and heavy twig dieback disease , respectively . The results showed that over‐dosage application of PP333 in successive years caused fruit tree early senility and server diseases infection .In order to cure the infected fruit trees , we applied a new home‐made chemical to the infected trees . The results showed that the home

  14. Treatment of pityriasis versicolor with topical application of essential oil of Cymbopogon citratus (DC Stapf - therapeutic pilot study Tratamento de pitiríase versicolor com aplicação tópica do óleo essencial de Cymbopogon citratus (DC Stapf - estudo terapêutico piloto

    Directory of Open Access Journals (Sweden)

    Egberto Santos Carmo

    2013-06-01

    Full Text Available BACKGROUND: Pityriasis versicolor is a fungal infection caused by Malassezia spp. that has frequent relapses. OBJECTIVES: The main objective of this research was to perform phase I and II clinical studies, using formulations containing essential oil of Cymbopogon citratus in patients with pityriasis versicolor. METHODS: Phase I study included twenty volunteers to ascertain the safety of the formulations. In phase II, 47 volunteers randomly received essential oil formulations at 1.25 μL/mL concentration, for forty days. The shampoo should be applied three times a week and the cream twice a day. A control group in phase II, consisting of 29 volunteers, received the same formulations but with 2% ketoconazole as the active ingredient. RESULTS: No significant adverse events were observed in volunteers during Phase I. In Phase II, 30 (63.83% volunteers using essential oil and 18 (62.07% using ketoconazole remained until the end of the study. We observed a predominance of lesions in disseminated form, with M. sympodialis detected as the predominant agent identified in cultures. After 40 days of treatment, the rate of mycological cure was 60% (p FUNDAMENTOS: Pitiríase versicolor é uma micose causada pela Malassezia spp., e que apresenta frequentes recidivas. OBJETIVOS: Este trabalho objetivou realizar estudos clínicos de fase I e II, para essa patologia, com óleo essencial de Cymbopogon citratus. MÉTODOS: Na fase I, participaram vinte voluntários para averiguar a segurança das formulações. Na fase II, 47 voluntários receberam as formulações do óleo essencial a 1,25 μL/mL, as quais deveriam ser utilizadas por quarenta dias, sendo o xampu três vezes por semana e o creme duas vezes ao dia. Um grupo controle na fase II, constituído por 29 voluntários recebeu as mesmas formulações, com cetoconazol a 2%. RESULTADOS: Verificada a segurança das formulações com a finalização da fase I, onde nenhuma reação adversa significativa foi

  15. Clinical efficacy of combined therapy of narrow-band ultraviolet B and 2% ketoconazole lotions for pityriasis versicolor%NB-UVB 联合2%酮康唑洗剂治疗花斑糠疹疗效观察

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    刘志超; 马凌云; 孙心君; 闫建军

    2016-01-01

    目的:观察窄谱中波紫外线(NB-UVB)联合2%酮康唑洗剂治疗花斑糠疹的临床疗效。方法120例花斑糠疹患者随机分为3组,A 组:单纯使用2%酮康唑洗剂外洗治疗,每日1次;B 组:NB-UVB 照射治疗,隔日照射1次;C 组:NB-UVB 与2%酮康唑洗剂联合治疗,方法分别与 A 组、B 组相同。治疗后4周观察3组患者皮疹消退的时间及真菌学检查结果并总结疗效。结果 A 组皮损消退的时间为(18.56±2.25)d,有效率72.5%;B 组患者照射次数为(6.28土1.37)次,累积照射剂量为(3619±697)mJ/ cm2,皮损消退的时间为(10.32±2.19)d,有效率77.5%;C 组患者照射次数为(3.77土1.52)次,累积照射剂量为(2152±889)mJ/ cm2,皮损消退的时间为(6.46±2.14)d,有效率97.5%;C 组皮损消退时间及有效率明显高于 A 组和 B 组(P <0.05)。结论 NB-UVB 联合2%酮康唑洗剂治疗花斑糠疹具有起效快、疗效高等优点,值得临床推广、应用。%Objective To observe the clinical efficacy of the combined therapy of narrow-band ultraviolet B and 2% ketoconazole lotions for Pityriasis versicolor. Methods One hundred and twenty patients with Pity-riasis versicolor were involved in this study. They were randomly divided into three groups and treated by dif-ferent therapies,respectively. Group A(40 patients)was only treated with 2% ketoconazole lotions,Group B (40 patients)only with narrow-band ultraviolet B,Group C(40 patients)with the combined therapy of nar-row-band ultraviolet B and 2% ketoconazole lotions. The average deflorescence duration and the result of mycology examination were analyzed. Results The average deflorescence duration was 18. 56 ± 2. 25 days, 10. 32 ± 2. 19 days and 6. 46 ± 2. 14 days in Group A,B and C,respectively. The effective rate was 72. 5% , 77. 5% and 97. 5% in Group A,B and C,respectively. The results of group comparison showed that there

  16. 基于小鼠温度趋向行为学表征的红参和西洋参寒热药性差异研究%Differences between cold and hot natures of processed Radix ginseng rubra and Panax quinquefolius L. based upon mice temperature tropism

    Institute of Scientific and Technical Information of China (English)

    张学儒; 赵艳玲; 王伽伯; 周灿平; 刘塔斯; 赵海平; 任永申; 鄢丹; 肖小河

    2009-01-01

    method to estimate the disparity between the cold and hot natures on the basis of an intrinsic correlation between temperature tropism of mice and the cold and hot natures of Chinese medicines. Methods Male KM mice were randomly divided into 7 groups of 6 each, namely the normal group (NM), the weak model group (WM), the strong model group (SM), the weak model plus Radix ginseng rubra group (WM + RG), the weak model plus Panax quinquefolius L. group (WM + PQ), the strong model plus Radix ginseng rubra group (SM + RG) and the strong model plus Panax quinquefolius L. group (SM + PQ). The specific herbal drugs were administered intragastricly. To induce the weak model, mice were fed with a limited supply of feed and forced to swim in cold water until almost drowning while the strong model induced by feeding a high-protein diet with an unlimited feed access. The doses of Radix ginseng rubra and Panax quinquefolius L. were 35 mg/g of body weight per day (counted by the quantity of crude materlal) and lasting for seven days. The NM and model groups without dosing were intragastricly administered with physiological saline of the same volume to the dosing groups. The percentage of the remaining time of mouse on a high temperature (40 ℃) pad to the total monitoring time was recorded by a self-designed intelligent animal behavior monitoring system. Meanwhile, the drinking volume of mice in each group was measured. Immediately after experiment, the activities of Na+ K+ -ATPase and superoxide dismutase (SOD) in liver tissue were measured by assay kits of phosphorus and xanthine oxidase methods respectively. Results The features of deficient and cold symptom, such as fatigue, stagnant weight growth, decreased water intake, cold limbs and tail etc, were observed in WM group. And the features of heat symptom, such as increased weight and water intake, hyperactivity etc, were observed in SM group. The percentage of time that the mouse remained on 40 ℃ pad of the WM group within the

  17. Diseases associated with hidranitis suppurativa: part 2 of a series on hidradenitis.

    Science.gov (United States)

    Scheinfeld, Noah

    2013-06-15

    diseases is likely underreported. Pyoderma vegetans has been noted in 2 cases of HS and 4 cases of Inflammatory Bowel Disease (IBD) and is likely a clue to the linkage of the pathology of IBD and HS. Pityriasis rubra pilaris, in particular Type VI related to HIV, has a relationship more commonly with acne conglobata, but with HS also. Single case reports of diseases associated with HS include systemic lupus erythematosus, acromegaly, Down syndrome, Bazex-Dupre´-Christol, and prurtis ani, but these might be coincidences. Pyogenic Arthritis, Pyoderma gangrenosum, and Acne (PAPA Syndrome) and Pyoderma gangrenosum, Acne, and Suppurative Hidradenitis (PASH Syndrome) are pyodermic-arthritic syndromes that are associated with HS. Erythema nodosum and granulomatous lobular mastitis have been reported with HS but the significance of these reports is uncertain. Because of scarring, HS can result in lymphedema including scrotal elephantiasis and verrucous lymphedema. HS is sometimes accompanied by obesity, hypertension, and anemia and can be considered a disease in the spectrum of metabolic syndrome, a skin disease with systemic consequences. HS, like other types of chronic inflammation when long standing in the perianal and perineal areas, can result in squamous cell cancer. A variety of drugs can induce HS. These include lithium, sirolimus, cyclosporine, vemurafenib, and oral contraceptives. Inverse psoriasis or psoriasis vulgaris as a side effect of infliximab therapy may be associated with HS. These associations aside, most cases of HS occur in isolation without coincident morbidity.

  18. Effect of Nocardia rubra Cell Wall Skeleton(N-cws)on Transplanted Tumor and Immunological Function in Mice Given Through Oral Administration%N-CWS灌胃对小鼠移植性肿瘤及免疫功能的影响

    Institute of Scientific and Technical Information of China (English)

    张祝兰; 唐文力; 杨煌建; 王娟; 洪金基

    2010-01-01

    为了考察红色诺卡氏菌细胞壁骨架(Nocardia rubra cell wall skeleton,N-CWS)灌胃给药对小鼠的体内抑瘤效应及其免疫调节作用,采用小鼠肉瘤S_(180)的移植性肿瘤模型,检测N-CWS灌胃给药的抑瘤活性;同时观察N-CWS体内细胞毒作用和对正常小鼠的毒性、免疫器官重量、巨噬细胞(MΦ)吞噬功能及脾淋巴细胞转化的影响.结果显示,小鼠灌服N-CWS的LD_(50)>1.2 g/kg;N-CWS 200、400、800 mg/kg剂量灌胃小鼠对S_(180)有明显的抑制作用,其抑瘤率分别为63.33%、71.11%、64.88%;与对照组比较,N-CWS可增加免疫器官重量和提升外周血白细胞数量、能明显提高小鼠MΦ的吞噬活性及显著提高淋巴细胞转化率(P<0.05),同时N-CWS激活了的MΦ对肿瘤细胞的细胞毒效应亦明显增强(P<0.05).因此N-CWS适用于口服给药,对小鼠移植性肿瘤有明显的抑制作用,其抗肿瘤作用可能与增强机体免疫功能有关.

  19. HPLC 法测定不同产地赤芍中芍药苷的含量及重金属和残留农药的分析%Analysis of Paeoniflorin,Residual Pesticide and Heavy Metal Content Determination in Radix Paeoniae Rubra from Different Habitats by HPLC

    Institute of Scientific and Technical Information of China (English)

    陈述

    2014-01-01

    目的:建立一种测定赤芍中芍药苷含量的高效液相色谱法,测定不同产地赤芍中芍药苷的含量并分析赤芍中重金属含量及农药的残留量。方法:色谱柱:Kromasil C18柱(5μm,4.6 mm ×250 mm);流动相:甲醇-0.05 mol/L 磷酸二氢钾(30∶70);波长:230 nm;柱温:25℃;流速:1.0 mL/min;进样量:10μL。采用原子吸收分光光度法对赤芍药材中的重金属铅、砷、铜、镉、汞进行分析,同时采用气相色谱法对有机氯类农药残留量进行测定。结果:芍药苷在0.1~1.0 mg/mL 范围内,浓度与峰面积的线性关系良好(R2=0.9996),样品的平均加样回收率为98.8%,RSD 为0.29%。17个不同产地的赤芍药材中芍药苷的含量为2.17%~4.17%;赤芍中检出铅、砷、铜、镉、汞的残留量分别为0.19~0.39、0.19~0.72、0.87~8.17、0.11~0.29和0.08~0.14 mg/kg;部分赤芍药材中有检出有机氯类,DHC、DDT、PCNB 的残留量分别为0.021~0.063、0.039~0.121和0.024~0.050 mg/kg。结论:17个产地的赤芍药材中芍药苷的含量均符合中国药典要求;药材存在一定量的重金属和有机氯类农药残留,除1份药材 DDT 含量超标外,其他药材的重金属及农药残留量均符合《药用植物及制剂进出口绿色行业标准》中的限量规定,赤芍药材总体质量较好。%Objective:To establish a HPLC method to determine the content of paeoniflorin as well as residual pesticide and heavy metal in Radix Paeoniae Rubra in different areas.Methods:Chromatographic column was Kromasil C18 column (5 μm,4.6 mm ×250 mm);mobile phase was methanol -0.05mol/L potassium dihydrogen phosphate (30:70);wavelength was 230 nm;column temperature was 25℃;flow rate was 1 mL/min;sample size was 10 L.Analysis of heavy metal lead,arsenic,copper,cadmium,mercury in Paeonia lacti-flora were determined by atomic absorption spectrophotometry,and gas

  20. Aspectos clínicos de pacientes com pitiríase versicolor atendidos em um centro de referência em dermatologia tropical na cidade de Manaus (AM, Brasil Clinical aspects of patients with pityriasis versicolor seen at a referral center for tropical dermatology in Manaus, Amazonas, Brazil

    Directory of Open Access Journals (Sweden)

    Patrícia Motta de Morais

    2010-12-01

    Full Text Available FUNDAMENTOS: A pitiríase versicolor (tinha versicolor é uma micose superficial crônica, causada por leveduras do gênero Malassezia spp. comensais das camadas queratinizadas da pele e que, sob determinadas condições ainda não esclarecidas, se torna patogênica, determinando as manifestações clínicas da doença. É uma dermatose recidivante e, mesmo após tratamento, pode deixar hipopigmentação persistente, causando problemas sociais aos indivíduos acometidos. OBJETIVO: Descrever as características clínicas e epidemiológicas de pacientes com diagnóstico de tinha versicolor atendidos em uma unidade de referência em Dermatologia (Fundação Alfredo da Matta. MÉTODOS: Estudo de série de casos em que foram detalhadas as manifestações cutâneas e as características epidemiológicas de pacientes atendidos na Fundação Alfredo da Matta com diagnóstico de tinha versicolor. RESULTADOS: Cento e dezesseis pacientes foram incluídos no estudo no período de janeiro a agosto de 2008. A maioria dos indivíduos é do sexo masculino, de cor parda, da faixa etária jovem e formada por estudantes, que apresentavam fatores predisponentes ao surgimento das manchas. Também a maioria apresentava lesões extensas e história passada da doença. CONCLUSÃO: O estudo mostrou alta proporção de indivíduos com quadros extensos e de longa duração da doença.BACKGROUND: Pityriasis versicolor (tinea versicolor is a chronic superficial mycosis caused by yeasts of the Malassezia spp. genus commensal of the keratinized layers of the skin. Under conditions not yet understood, it becomes pathogenic determining the clinical manifestations of the disease. It is a recurrent skin condition and persistent hypopigmentation may remain after treatment, causing social problems to those affected. OBJECTIVE: To describe the clinical and epidemiological features of patients diagnosed with tinea versicolor treated at a referral center for dermatology (Alfredo da

  1. Pityriasis versicolor: clinical-epidemiological characterization of patients in the urban area of Buerarema-BA , Brazil Pitiríase versicolor: caracterização clínico-epidemiológica em pacientes da área urbana de Buerarema-BA, Brasil

    Directory of Open Access Journals (Sweden)

    Juliano Oliveira Santana

    2013-04-01

    Full Text Available BACKGROUND: Pityriasis versicolor (PV is a cutaneous pigmentation disorder caused by a lipophilic yeast of the genus Malassezia sp. It is a superficial mycosis characterized by well-defined, slightly scaly skin lesions of variable color. In Brazil, the number of reported cases is small, and there are few epidemiological studies. OBJECTIVES: to assess incidence, characteristics of the lesions, effectiveness of the Zileri's Sign procedure, and the epidemiological profile of PV in the urban area of Buerarema - Bahia. METHODS: Biological samples were collected on pre-established days at Basic Health Care Units from July to September 2010. Sample collection was followed by laboratory diagnosis using Porto's Method. RESULTS: Of the 158 patients with suspected PV participating in the study, 105 (66.5% were positive; 72 (68.6% were female and 33 (31.4% were male. Sex and location of lesions showed statistically significant differences (p FUNDAMENTOS: A pitiríase versicolor é um distúrbio de pigmentação cutânea causada pela levedura lipofílica do gênero Malassezia sp. É uma micose superficial caracterizada por produzir lesões delimitadas, com descamação fina e de cor variável. No Brasil, o relato do número de casos e de estudos é restrito. OBJETIVOS: Analisar a incidência, as características das lesões, a eficácia do Sinal de Zileri e o perfil epidemiológico da pitiríase versicolor na área urbana do município de Buerarema-BA. MÉTODOS: Foram coletadas amostras biológicas no período de julho a setembro de 2010, em dias pré-establecidos, nas Unidades Básicas de Saúde. O Método de Porto foi utilizado como diagnóstico laboratorial. RESULTADOS: Dos 158 pacientes cadastrados com suspeita de pitiríase versicolor, 105 (66,5% mostraram-se positivos, sendo 72 (68,6% do sexo feminino e 33 (31,4% do sexo oposto. Ocorreu diferença estatisticamente significante entre sexo e localização das lesões (p<0,05. A região com maior

  2. Akvareli Aleksandra Pilara / Nelli Kuznetsova

    Index Scriptorium Estoniae

    Kuznetsova, Nelli

    2000-01-01

    Aleksander Pilari akvarellinäitusest Tallinna Vene saatkonna galeriis. Organiseeris poeg Boris Pilar Eesti Kunstimuuseumi ja erakogudest. Näituse avamisel Mai Levin A. Pilari loomingust. A. Pilari kuulsast suguvõsast.

  3. Akvareli Aleksandra Pilara / Nelli Kuznetsova

    Index Scriptorium Estoniae

    Kuznetsova, Nelli

    2000-01-01

    Aleksander Pilari akvarellinäitusest Tallinna Vene saatkonna galeriis. Organiseeris poeg Boris Pilar Eesti Kunstimuuseumi ja erakogudest. Näituse avamisel Mai Levin A. Pilari loomingust. A. Pilari kuulsast suguvõsast.

  4. Microsatellite markers for northern red oak (Fagaceae: Quercus rubra)

    Science.gov (United States)

    Preston R. Aldrich; Charles H. Michler; Weilin Sun; Jeanne Romero-Severson

    2002-01-01

    We provide primer sequences for 14 (GA)n microsatellite loci developed from northern red oak, an important timber species. We screened loci using two sets of samples. A parent-offspring set included DNA from seven acorns collected from one mother tree along with maternal DNA, to determine that all progeny carried a maternal allele at each locus....

  5. Effect of Radix Paeoniae Rubra and Radix Paeoniae Alba with same origin on immune function of mice and the similarity by comparing with chemical constituents%同基原赤、白芍增强小鼠免疫作用的异同及成分相似度比较

    Institute of Scientific and Technical Information of China (English)

    王芍; 孙杰; 马丁; 郭斌; 范建礼; 尉亚辉

    2011-01-01

    OBJECTIVE To study the effects of Radix Paeoniae Alba (PRA) and Radix Paeoniae Rubra (PRR) with some origin on immunological function of ICR mice, and to investigate the material foundation of pharmacological effects by comparing the chemical constituents. METHODS Cyclophosphamide (CTX, ip) induced immunosuppressed mice were randomly divided into 9 groups. Tested groups intaked 50 ~ 500 mg·mL-1 PRA or 70 ~ 700 mg·mL-1 PRR, the group intaked 1 mg·mL- 1 thymosin as positive control Carbon granule clearance, delayed type hypersensitivity, the contents of hemonlysin and phagocytic activity of peritoneal macrop hagea were measured. And then compared PRA and PRR extract by HPLC. RESULTS PRA and PRR herb extract could obviously enhance the weight of immune organ (P<0. 05), the percentage of phagocytosis, the macrophage phagocytosis index (P<0. 01 ) as well as the hemolysin antibody level (P<0. 01 ) of treated groups. The results of HPLC results indicated 17 common characteristic peaks (similarity is 81.29%) in PRA and PRR extract under 230 nm. CONCLUSION In this research, the same origin PRA and PRR showed a similar immuno-enhancing capacity in mice, the similar inclusions are respond for the immuno-enhancing activity.%目的:探讨同基原赤、白芍增强小鼠免疫作用的异同并比较其化学成分的相似度,寻求免疫作用的物质基础.方法:腹腔注射环磷酰胺复制免疫低下动物模型,随机分为赤、白芍高、中、低剂量组、空白组、阳性时照组,测定碳粒廓清、迟发型超教反应、血清溶血素含量以及巨噬细胞吞噬功能;采用HPLC法分析比较起效赤、白芍提取物中的化学成分.结果:赤、白芍给药组与对照组相比,均能显著提高免疫低下模型小鼠免疫器官质量(P<0.05)、极显著增强巨噬细胞吞噬能力(P<0.01)、极显著升高血清溶血素的含量(P<0.01).此外,HPLC图谱显示本次试验中的赤、白芍起效成分提取物在230nm

  6. Role of p38 mitogen activated protein kinase pathway in attenuation of LPS-induced acute lung injury by Radix Paeoniae Rubra in rats%p38MAPK/iNOS/HO-1信号通路在赤芍减轻大鼠内毒素性急性肺损伤中的作用

    Institute of Scientific and Technical Information of China (English)

    詹丽英; 夏中元; 夏芳; 刘先义

    2009-01-01

    Objective To investigate the role of p38 mitogen activated protein kinase(MAPK)iNOSI/HO-1 in attenuation of LPS-induced acute lung injury(ALI)by Radix Paeoniae Rubra (RPR) in rats.Methods Forty pathogen-free male Wistar rats weighing 200-250 g were randomly divided into 5 groups(n=8 each):group Ⅰ I control(C);groupⅡLPS;group Ⅲ RPR;group Ⅳ RPR precondtioning and group Ⅴ SB203580 (p38MAPK specific inhibitor).ALI Wag induced by slow intra-tracheal instillation of LPS 2.5 mg/kg in 1 ml of normal saline(NS)in groupⅡ-Ⅴ.BPR 30 mg/kg waft infused iv over 2h simultaneouslv with and at 2 h before intra.tracheal LPS instillation in group Ⅲ and Ⅳ respectively.In groupⅤ SB203580 5,μmol/kg Was infused iv over 2 h at 3 h before intra-tracheal LPS instillation.Arterial blood samples were taken at 6 h after intra-Iracheal LPS instillation for blood gas analysis and determination of serum NO concenwafion.The animals were sacrificed bv exsangulnation.The lunga were immediately removed for microscopic examination and determination of p38MAPK and HO-I and iNOS expression and MDA content in the lung tissue.The left lung was lavaged and broncho- alveolar lavage fluid(BALF)Wag collected for determination of neutrophil count and protein COilcentration.Results LPS intra-tracheal instillation significantly decreased PaO2,PaCO2 and HCO3- concentration and increased serum NO concentration, the number of neutrophils and protein concentration in BALF, and p38MAPK and iNOS and HO-I expression and MDA content in the lung tissue. RPR and RPB preconditioning and SB203580 significandy attenuated the LPS-induced changes in group Ⅲ ,ⅣandⅤ as compared with group Ⅱ . The LPS intratracheal instillation induced pathologic changes of the lung were also attenuated in group ⅢⅣ and Ⅴ.Conclusion RPB can attenuate LPS-indueed ALl through p38MAPK/iNOS/HO-1 signalling pathway.%目的 评价p38MAPK/iNOS/HO-1信号通路在赤芍减轻大鼠内毒素性急性肺损伤(AL1)

  7. Genetic illnesses of the skin

    Directory of Open Access Journals (Sweden)

    Yordania Velázquez Avila

    2015-09-01

    Full Text Available At present, many genetic diseases, from 85 to 90 %, are considered rare diseases, since they affect a small number of individuals. The poor knowledge about them makes it difficult to diagnose them; they are chronic, incapacitating, with few therapeutic options diseases and often makes the patients’ adequate social integration impossible. The genodermatosis are part of the group of rare, uncommon and difficult to diagnose skin diseases; they are a frequent cause of stigmatization of those people who suffer from them. They may include: ichthyosis, epidermolysis bullosa, mastocytosis, neurofibromatosis, ectodermal dysplasia, palmoplantar keratoderma, Ehlers-Danlos syndrome, incontinentia pigmenti, pityriasis rubra pylaris, xeroderma pigmentosum, epiloia, Darier's disease, and vascular tumors, among others. It is necessary to increase knowledge about them in the field of medical sciences, allowing a better treatment for patients and improve their quality of life, as well as contribute to their prevention.

  8. 多元PCR在黑鲍(Haliotis rubra)微卫星遗传研究中的应用%MULTIPLEX PCR APPLICATION IN MICROSATELLITE OF HALIOTIS RUBRA

    Institute of Scientific and Technical Information of China (English)

    黎中宝; Appleyard Sharon A; Elliott Nicholas G

    2005-01-01

    根据D03等11个微卫星引物单位点PCR扩增时优化的扩增条件(退火温度、MgCl2等)和11个微卫星引物所带有的荧光颜色、等位基因大小变异范围及反应的灵敏度,可将11个微卫星引物分成A组(D03、G04、B04和H08)、B组(A09、H11、A08和G01)和C组(CmrHr1.24、CmrHr2.30和CmrHr2.23)进行多元PCR扩增,结果显示各组内位点之间的分离清晰,这表明多元PCR可以大大提高微卫星检测仪器的使用效率和提高实验效果,在微卫星研究中是一种快速便捷的方法.

  9. Investigations of the cerebral blood flow by means of nuclear medicine in polycythemia vera rubra. Untersuchungen des zerebralen Blutflusses bei Polyzythaemia vera rubra mit nuklearmedizinischen Methoden

    Energy Technology Data Exchange (ETDEWEB)

    Franke, W.G. (Medizinische Akademie Dresden, Klinik und Poliklinik fuer Nuklearmedizin (Germany)); Unger, L. (Medizinische Akademie Dresden, Klinik und Poliklinik fuer Psychiatrie und Neurologie (Germany)); Mueller, J. (Medizinische Akademie Dresden, Klinik und Poliklinik fuer Psychiatrie und Neurologie (Germany))

    1993-04-01

    P.v. represents a ''clinical model'' of diagnostic radionuclide application to evaluate the total and regional perfusion of brain. 107 polycythemians treated by or provided for radiophosphorus were studied by neurologic methods as EEG e.g. and with XCT if necessary. These studies were accomplished repeatedly in 62% of the surveyed patients. We found disturbed perfusion in brain: 32, diminuation of blood flow in vertebral-basilar region: 8, polyneuropathies: 27, psychic abnormalities: 60. Therapeutic effects became ascertained in 34% of hemipareses. The majority of polycythemic patients let recognize a regression of subjective complaints. The diagnostic informations obtained by radionuclide methods were compared to clinical and neurologic results as mentioned above. A good correlation could observed from radionuclide angiography, [sup 133]Xe-studies of total and regional cerebral perfusion and HMPAO-SPECT to neurologic and radiological findings. 66% of studied patients showed abnormal radioactivity distribution at static scintigrams. Disturbances of cerebral perfusion were seen in 20 from 26 patients if radionuclide angiography was used. Especially the inflow to cerebral vessels was found retarded by this method. Even in 3 neurologically inconspicuous persons the cerebral perfusion was restricted. Only 5 patients without signs of decreased flow could be seen. In 9 of 10 cases studied using [sup 133]Xenon referred to diminuation of cerebral perfusion. Both dynamic methods showed changes in perfusion depending from time course. Numerous localized defects of vascularization were detected by SPECT in some corresponding with neurologic symptoms in other patients differing from these ones. (orig./MG)

  10. Keratinocyte detachment-differentiation connection revisited, or anoikis-pityriasi nexus redux.

    Directory of Open Access Journals (Sweden)

    Tomohiro Banno

    Full Text Available Epidermis, a continuously self-renewing and differentiating organ, produces a protective stratum corneum that shields us from external chemical, physical and microbial threats. Epidermal differentiation is a multi-step process regulated by influences, some unknown, others insufficiently explored. Detachment of keratinocytes from the basement membrane is one such pro-differentiation stimulus. Here, we define the transcriptional changes during differentiation, especially those caused by detachment from the substratum. Using comprehensive transcriptional profiling, we revisited the effects of detachment as a differentiation signal to keratinocytes. We identified the genes regulated by detachment, the corresponding ontological categories and, using metaanalysis, compared the genes and categories to those regulated by other pro-differentiating stimuli. We identified 762 genes overexpressed in suspended keratinocyte, including known and novel differentiation markers, and 1427 in attached cells, including basal layer markers. Detachment induced epidermis development, cornification and desmosomal genes, but also innate immunity, proliferation inhibitors, transcription regulators and MAPKs; conversely the attached cells overexpressed cell cycle, anchoring, motility, splicing and mitochondrial genes, and both positive and negative regulators of apoptosis. Metaanalysis identified which detachment-regulated categories overlap with those induced by suprabasal location in vivo, by reaching confluency in vitro, and by inhibition of JUN kinases. Attached and in vivo basal cells shared overexpression of mitochondrial components. Interestingly, melanosome trafficking components were also overexpressed in the attached and in vivo basal keratinocytes. These results suggest that specific pro-differentiation signals induce specific features of the keratinization process, which are in vivo orchestrated into harmonious epidermal homeostasis.

  11. Keratinocyte detachment-differentiation connection revisited, or anoikis-pityriasi nexus redux.

    Science.gov (United States)

    Banno, Tomohiro; Blumenberg, Miroslav

    2014-01-01

    Epidermis, a continuously self-renewing and differentiating organ, produces a protective stratum corneum that shields us from external chemical, physical and microbial threats. Epidermal differentiation is a multi-step process regulated by influences, some unknown, others insufficiently explored. Detachment of keratinocytes from the basement membrane is one such pro-differentiation stimulus. Here, we define the transcriptional changes during differentiation, especially those caused by detachment from the substratum. Using comprehensive transcriptional profiling, we revisited the effects of detachment as a differentiation signal to keratinocytes. We identified the genes regulated by detachment, the corresponding ontological categories and, using metaanalysis, compared the genes and categories to those regulated by other pro-differentiating stimuli. We identified 762 genes overexpressed in suspended keratinocyte, including known and novel differentiation markers, and 1427 in attached cells, including basal layer markers. Detachment induced epidermis development, cornification and desmosomal genes, but also innate immunity, proliferation inhibitors, transcription regulators and MAPKs; conversely the attached cells overexpressed cell cycle, anchoring, motility, splicing and mitochondrial genes, and both positive and negative regulators of apoptosis. Metaanalysis identified which detachment-regulated categories overlap with those induced by suprabasal location in vivo, by reaching confluency in vitro, and by inhibition of JUN kinases. Attached and in vivo basal cells shared overexpression of mitochondrial components. Interestingly, melanosome trafficking components were also overexpressed in the attached and in vivo basal keratinocytes. These results suggest that specific pro-differentiation signals induce specific features of the keratinization process, which are in vivo orchestrated into harmonious epidermal homeostasis.

  12. 茄子佐治花斑癣%Using Eggplant in Axilliary to Treat Pityriasis Versicolor

    Institute of Scientific and Technical Information of China (English)

    谷杰法

    2001-01-01

    用硫磺、雄黄等份,研末,将鲜茄子横断,以切面蘸硫磺、雄黄末在患处反复摩擦,每日2~3次,每次约半小时,10日为1个疗程。此乃民间治疗花斑癣(汗斑)验方。笔者试用此法治疗花斑癣数例,皆在10日内痊愈,疗效满意。

  13. [Labor epidural analgesia for a woman with a pityriasis versicolor in the lumbar region].

    Science.gov (United States)

    Dubar, G; Omarjee, M; Viguié, C; Barbarot, S; Mignon, A

    2011-01-01

    Epidural analgesia is usually contraindicated in case of infection at the site of needle insertion. Tinea versicolor is a benign superficial cutaneous fungal infection caused by the proliferation of a skin commensal yeast of low pathogenicity. We report the case of a pregnant woman with a tinea versicolor in the lumbar region, who benefited from a labor epidural analgesia, realised with reinforced antiseptic measures. No neurological or infectious complication occurred.

  14. Pityriasis lichenoides et varioliformis acuta%急性痘疮样苔藓状糠疹

    Institute of Scientific and Technical Information of China (English)

    徐素芹; 丁政云; 高顺强; 林元珠; 张增强; 李彦群

    2004-01-01

    患者男,51岁。主诉:全身红斑、丘疹、水疱、鳞屑伴瘙痒1个月余。现病史:1个月前无明显诱因在腹部、背部出现散在的红斑、丘疹伴瘙痒。当地卫生院诊断为过敏性皮炎,给予马来酸氯苯那敏、维生素C口服,外用曲安奈德尿素软膏等治疗,无明显疗效,皮疹逐渐增多,渐波及全身。既往身体健康,无类似皮疹史。家族中亦无类似患者。

  15. Phenology, dichogamy, and floral synchronization in a northern red oak (Quercus Rubra L.) seed orchard

    Science.gov (United States)

    We developed a novel scoring system to assess spring phenology in a northern red oak clonal seed orchard. The system was used to score between 304 and 364 ramets for three reproductive seasons and place clones into early, middle, and late phenology groups. While the absolute number of clones in ea...

  16. Antidiabetic activity of Plumeria rubra L. in normal and alloxan induced diabetic mice

    Directory of Open Access Journals (Sweden)

    Amruta V. Yadav

    2016-06-01

    Conclusions: PR exhibited significant antihyperglycemic activity in normal and alloxan-induced diabetic mice. The results of the present study provide support to the traditional usage of the plant in diabetes. [Int J Basic Clin Pharmacol 2016; 5(3.000: 884-889

  17. Classification of papulo-squamous skin diseases using image analysis.

    Science.gov (United States)

    Mashaly, H M; Masood, N A; Mohamed, Abdalla S A

    2012-02-01

    Papulo-squamous skin diseases are variable but are very close in their clinical features. They present with the same lesions, erythematous scaly lesions. Clinical evaluation of skin lesions is based on common sense and experience of the dermatologist to differentiate features of each disease. To evaluate a computer-based image analysis system as a helping tool for classification of commonly encountered diseases. The study included 50 selected images from each of psoriasis, lichen planus, atopic dermatitis, seborrheic dermatitis, pityrasis rosea, and pitryasis rubra pilaris with a total of 300 images. The study comprised three main processes peformed on the 300 included images: segmentation, feature extraction followed by classification. Rough sets recorded the highest percentage of accuracy and sensitivity of segmentation for the six groups of diseases compared with the other three used techniques (topological derivative, K-means clustering, and watershed). Rule-based classifier using the concept of rough sets recorded the best percentage of classification (96.7%) for the six groups of diseases compared with the other six techniques of classification used: K-means clustering, fuzzy c-means clustering, classification and regression tree, rule-based classifier with discretization, and K-nearest neighbor technique. Rough sets approach proves its superiority for both the segmentation and the classification processes of papulo-squamous skin diseases compared with the other used segmentation and classification techniques. © 2011 John Wiley & Sons A/S.

  18. Сравнительное изучение аминокислотного состава листьев шелковицы черной (Morus nigra L. ), шелковицы белой (Morus alba L. ) и шелковицы красной (Morus rubra L. )

    OpenAIRE

    Селина, И.

    2014-01-01

    Изучен качественный и количественный состав аминокислот листьев шелковицы черной (Morus nigra L.), шелковицы белой (Morus alba L.) и шелковицы красной (Morus rubra L.). Методом тонкослойной хроматографии (ТСХ) с использованием стандартных образцов аминокислот осуществлен предварительный анализ содержания свободных аминокислот. Установлено, что в исследуемых образцах идентифицированы глицин, глутаминовая кислота, метионин, тирозин. Дальнейшее определение суммы аминокислот определяли на аминоки...

  19. 局限型慢性苔藓样糠疹%A case of localized pityriasis lichenoides chronica

    Institute of Scientific and Technical Information of China (English)

    谭城; 朱文元; 闵仲生

    2009-01-01

    报告1例局限型慢性苔藓样糠疹.患者女,28岁.左肘关节屈侧反复出现瘙痒性红色斑丘疹、鳞屑3年.皮肤科检查:左肘关节屈侧及附近皮肤见红斑、斑丘疹及鳞屑,其中夹杂有色素减退斑、瘢痕.皮损组织病理检查示表皮角化过度,局灶性角化不全和轻度海绵水肿;真皮浅层血管扩张充血明显,红细胞外渗,血管周围少量淋巴细胞浸润.根据临床和组织病理特点,诊断为局限型慢性苔藓样糠疹.

  20. The Determination on Quality for Mongolian Medicine Corallin Rubra%蒙药珊瑚的质量控制

    Institute of Scientific and Technical Information of China (English)

    王烈群; 顾艳丽; 许丽萍; 那顺朝克图; 乔婷; 梁艳; 菅月婷

    2008-01-01

    目的:研究蒙药珊瑚及炮制品的质量控制方法.方法:采用EDTA法测定珊瑚及其炮制品中CaCO的含量;参照相关方法检查重金属及砷盐.结果:蒙药珊瑚及炮制品的碳酸钙(CaCO)含量均在80%以上;重金属含量均未超过百万分之二十;砷盐的含量在4PPM以下.结论:本研究为珊瑚及炮制品的质量控制提供依据.

  1. A rare case of woolly hair with unusual associations

    Directory of Open Access Journals (Sweden)

    Biju Vasudevan

    2013-01-01

    Full Text Available Woolly hair is a congenital abnormality of scalp hair manifesting as short, kinked hair, which may also involve the hair over the other parts of the body. Keratosis pilaris has been a well known association of woolly hair, and can also be a part of the Naxos or Carvajal syndromes. We herein present a case of woolly hair with associated keratosis pilaris, canaliform dystrophy of nails, increased interdental spaces and recurrent bullous impetigo. Although keratosis pilaris and teeth abnormalities have been reported as isolated associations with woolly hair, such a combination of findings as seen in our patient has not been reported before.

  2. 汗斑患者马拉色菌流行病学资料分析%Epidemiologic analysis of Malassezia in pityriasis versicolor

    Institute of Scientific and Technical Information of China (English)

    陶诗沁; 陈炜; 张海萍; 胡素泉; 陈伟; 沈永年; 杨莉佳; 刘维达

    2005-01-01

    为了解马拉色菌各种类在汗斑患者中的分布情况,笔者使用Leeming-Norman培养基培养马拉色菌镜检阳性的汗斑患者皮肤样本,然后分离菌株进行菌种鉴定。

  3. 急性痘疮样苔藓样糠疹1例%A case of pityriasis lichenoides of rarioliformis acuta

    Institute of Scientific and Technical Information of China (English)

    任昊远; 彭少文; 李俊

    2011-01-01

    @@ 临床资料 患者,男,30岁.主因躯干、四肢起皮疹1天,于2011年1月2日就诊.患者1天前无明显诱因,躯干、四肢出现红斑、丘疹、丘疱疹,无明显自觉症状,逐渐增多,遂来我科就诊.患者起病以来,无畏寒发热,腹痛、腹泻等症状.患者平素体健,家族中均无类似疾病史.

  4. 急性痘疮样苔藓样糠疹1例%A Case of Pityriasis Lichenoides et Varioliformis Acuta

    Institute of Scientific and Technical Information of China (English)

    何磊; 党林; 栗玉珍

    2012-01-01

    Objective To understand the clinical features of eosinophilic pustular folliculitis ( EPF). Methods We reported an EPF patient and performed the clinical analysis for all the patients published in Chinese journals in recent ten years. Results There were 19 males and 1 female in these patients. EPF is a rare dermatosis characterized by recurrent outbreaks of papulopustular skin lesions mainly distributed in seborrheic areas ( mainly on the face, upper back, and upper extremities. ) as annular form. EPF could be associated with AIDS. We found that peripheral blood eosinophils increasing in 15 cases and non-increasing in 5 cases. Conclusion The incidence of EPF in male is higher than that in females. There are different clinical features in different patients. EPF could be accompanied with the increasing of peripheral blood eosinophils.%患者女,48岁.周身泛发性红色丘疹、丘疱疹伴瘙痒10余日,皮疹多为粟粒至黄豆大小,上覆少许薄鳞屑,Ausptiz征(-),部分皮损破溃、坏死、血痂.皮损组织病理示:表皮细胞间水肿及细胞内水肿形成多房性表皮内疱,疱内见中性粒细胞及多量红细胞,基底细胞液化,区域性淋巴样细胞浸润.诊断:急性痘疮样苔藓样糠疹.

  5. 局部用药治疗慢性苔藓样糠疹1例%Local treatment of pityriasis lichenoides chronica:A case report

    Institute of Scientific and Technical Information of China (English)

    张国毅; 曾学思

    2000-01-01

    @@ 1 临床资料:患者男性,22岁.因四肢、躯干起淡红褐色丘疹10年就诊.10年前无明显诱因发现双上肢起米粒大淡褐色、淡红色皮损,多数与皮肤一样平,仅少数皮损稍高出皮面,不痒、不痛.半年后发现胸、背、下肢亦有类似皮损.随年龄增长皮损缓慢扩大,从无消退现象,数量上增加不甚明显,但颜色缓慢逐渐加深,部分呈灰褐色.

  6. 急性痘疮样苔藓样糠疹1例%A case of pityriasis lichenoides et varioliformis acuta

    Institute of Scientific and Technical Information of China (English)

    王连祥

    2010-01-01

    @@ 临床资料 患儿,男,3岁.主因全身出现红斑、丘疹伴瘙痒1月余,于2009年6月11日来我院就诊.1个月前患儿无明显诱因背部出现红斑、丘疹,渐累及全身,且出现水疱、脓疱、结痂,自觉瘙痒,外涂"糠酸莫米松乳膏"后症状稍缓减,但停药后加重.既往健康,否认家族成员有类似病史.

  7. The New World tarantula-hawk wasp genus Pepsis Fabricius (Hymenoptera: Pompilidae). Part 1. Introduction and the P. rubra species-group

    NARCIS (Netherlands)

    Vardy, C.R.

    2000-01-01

    The genus Pepsis is diagnosed and described, and its taxonomic and natural history reviewed. The following are newly synonymized under this genus: the genera Abripepsis Banks, 1946 and Brethesia Schrottky, 1909; and all the existing subgenera of Pepsis, viz. Chrysopepsis Haupt, 1952; Cirripepsis Ban

  8. 蒙药白硇砂中含量测定方法研究%The determination on quanlity for mongolian medicine Corallin Rubra

    Institute of Scientific and Technical Information of China (English)

    顾艳丽; 王烈群; 许丽萍; 臧艳艳; 关翠薇; 赵元琦

    2008-01-01

    白硇砂作为蒙药“赫勒-朝日格其-达布斯”始载于《认药白晶鉴》,主含氯化铵(NH4Cl)。性味咸、苦、辛、温、有毒。在蒙医药临床应用中,具有利尿、泻脉疾、消水肿、止腐、燥协日沃素、解毒、收缩子宫、去翳等功效。用于尿闭、水肿、肾热、膀胱热、膀胱结石、结喉、疮疡、云翳、目赤、宫缩无力、胎衣不下。白硇砂本品主要成分为氯化铵,我们参照《药典》2005版二部氯化铵项下的含量测定方法,测定白硇砂中氯化铵的含量。

  9. Pollen gene flow, male reproductive success, and genetic correlations among offspring in a northern red oak (Quercus rubra L.) seed orchard.

    Science.gov (United States)

    Alexander, Lisa; Woeste, Keith

    2017-01-01

    Northern red oak is a high-value hardwood used for lumber, furniture and veneer. Intensively managed northern red oak seed orchards are required to obtain genetic gain for trait improvement. Data from conifer seed orchards and natural and managed stands of hardwood trees have shed light on the distance over which pollen can move, and underscore the need for managerial attention to seed orchard design, placement, and maintenance. We used eleven microsatellite markers to investigate pollen gene flow, female mate choice, and male reproductive success in a clonal seed orchard of northern red oak based on paternity analysis of seed orchard offspring in progeny tests. Nearly all (93%) offspring were sired by a male parent within the seed orchard. The mean number of male parents per year was 69.5, or 47.6% of all clones in the seed orchard. Female clones in the early phenology group had more offspring sired from extra-orchard pollen (13%) than clones in the intermediate (5%) and late (1%) phenology groups. Distance was the largest influence on pollination success, and pollination occurred most often by male trees in the same subline as the maternal tree. Males in the early phenology group sired more offspring overall in the progeny pool and more offspring per mother tree than males in the intermediate or late phenology groups. Average genetic correlations among all OP progeny ranged between 0.2557 and 0.3529 with a mean of 0.28±0.01. The importance of progeny test genotyping for northern red oak improvement likely is increasing with the demand for improved varieties. The current study demonstrated the feasibility of post hoc assembly of full-sib families for genetic analysis.

  10. Etude expérimentale et comparative de la myrmécochorie: le cas de la fourmis dispersatrices Lasius niger et Myrmica rubra

    OpenAIRE

    Servigne, Pablo

    2008-01-01

    Ce travail porte sur la dispersion des graines par les fourmis et se divise en deux parties :l’une expérimentale (Chapitres 1, 2 & 3) et l’autre synthétique (Chapitres 4 & 5). L’approche expérimentale a consisté en une exploration en conditions de laboratoire des comportements des fourmis à deux étapes du processus de myrmécochorie: à la source de graines et dans le nid. Des graines des plantes myrmécochores Viola odorata et Chelidonium majus ont été présentées aux fourmis Lasius niger et Myr...

  11. HEAVY METAL ANALYSIS IN RED OAK (QUERCUS RUBRA POPULATIONS FROM A MINING REGION IN NORTHERN ONTARIO (CANADA: EFFECT OF SOIL LIMING AND ANALYSIS OF GENETIC VARIATION

    Directory of Open Access Journals (Sweden)

    Anh Tran

    2014-01-01

    Full Text Available Understanding the dynamic of metals in soil and plants and population diversity in Northern Ontario is essential in determining progress toward ecosystem sustainability in reclaimed sites. The objectives of the present study were to assess the levels of metal content in soils and their accumulation in red oak plants from limed and unlimed sites. Genetic variation in red oak populations from the Northern Ontario region was also analyzed. The levels of soil acidity was lower in limed areas compared to un limed sites, an indication of the prolonged beneficial effect of liming 20 to 30 years ago on soil toxicity. The levels of total metals were very high for most elements, but the proportion of metals that were bio available and readily available to plants was very small. The enrichment factors were16.78, 4.98 and 2.94 for total arsenic, copper and nickel, respectively. The Translocation Factor (TF values for available metals from soil to branches were high. There was more metal accumulation in leaves compared to branches. The degrees of genetic variability in red oak populations from limed and unlimed areas were compared using ISSR markers. The levels of polymorphic loci were moderate to high ranging from 44 to 65%. There were no significant differences in polymorphisms between areas that were limed and unlimed. Overall the red oak populations in stressed areas in Northern Ontario are sustainable.

  12. Pollen gene flow, male reproductive success, and genetic correlations among offspring in a northern red oak (Quercus rubra L.) seed orchard

    Science.gov (United States)

    Woeste, Keith

    2017-01-01

    Northern red oak is a high-value hardwood used for lumber, furniture and veneer. Intensively managed northern red oak seed orchards are required to obtain genetic gain for trait improvement. Data from conifer seed orchards and natural and managed stands of hardwood trees have shed light on the distance over which pollen can move, and underscore the need for managerial attention to seed orchard design, placement, and maintenance. We used eleven microsatellite markers to investigate pollen gene flow, female mate choice, and male reproductive success in a clonal seed orchard of northern red oak based on paternity analysis of seed orchard offspring in progeny tests. Nearly all (93%) offspring were sired by a male parent within the seed orchard. The mean number of male parents per year was 69.5, or 47.6% of all clones in the seed orchard. Female clones in the early phenology group had more offspring sired from extra-orchard pollen (13%) than clones in the intermediate (5%) and late (1%) phenology groups. Distance was the largest influence on pollination success, and pollination occurred most often by male trees in the same subline as the maternal tree. Males in the early phenology group sired more offspring overall in the progeny pool and more offspring per mother tree than males in the intermediate or late phenology groups. Average genetic correlations among all OP progeny ranged between 0.2557 and 0.3529 with a mean of 0.28±0.01. The importance of progeny test genotyping for northern red oak improvement likely is increasing with the demand for improved varieties. The current study demonstrated the feasibility of post hoc assembly of full-sib families for genetic analysis. PMID:28166543

  13. The New World tarantula-hawk wasp genus Pepsis Fabricius (Hymenoptera: Pompilidae). Part 1. Introduction and the P. rubra species-group

    NARCIS (Netherlands)

    Vardy, C.R.

    2000-01-01

    The genus Pepsis is diagnosed and described, and its taxonomic and natural history reviewed. The following are newly synonymized under this genus: the genera Abripepsis Banks, 1946 and Brethesia Schrottky, 1909; and all the existing subgenera of Pepsis, viz. Chrysopepsis Haupt, 1952; Cirripepsis

  14. Encapsulation of Red Cabbage (Brassica oleracea L. var.capitata L. f. rubra Anthocyanins by Spray Drying using Different Encapsulating Agents

    Directory of Open Access Journals (Sweden)

    Anahi Bernstein

    2015-12-01

    Full Text Available ABSTRACT This study aimed to evaluate the influence of the drying air temperature (140 and 160°C and the concentration of encapsulating agents gum Arabic and polydextrose (10 and 15% on the physicochemical characteristics of the red cabbage extract obtained through extraction in acidulated water and drying using a spray dryer. The anthocyanin retention, antioxidant activity, water activity, solubility, color and microstructure of the final product were analyzed. Results showed that increase in the temperature did not cause significant changes in the anthocyanin quantity and antioxidant activity. The microscopic analysis revealed that for both the encapsulating agents, the absence of fissures and porosity in the particle surfaces produced powder with high solubility in water. The principal component analyses showed a strong correlation between the anthocyanin content and the antioxidant activity (r = 0.82 and luminosity (r = 0.81.

  15. Distance and phenology influence pollen gene flow, male reproductive success, and female mate choice in a northern red oak (Quercus rubra L.) seed orchard

    Science.gov (United States)

    Northern red oak is a high-value hardwood used for lumber, furniture and veneer. Intensively managed northern red oak orchards require genetic gain for trait improvement. Data from conifer seed orchards and natural and managed stands of hardwood trees have shed light on the distance over which polle...

  16. "Sokrovishtsha mirovogo iskusstva v Tallinne" / Boris Pilar von Pilhau

    Index Scriptorium Estoniae

    Pilar von Pilhau, Boris

    2006-01-01

    Boris Pilari ja Jevgeni Rogovi kunstiprojektist "Maailma kunstiaarded Tallinnas", selle raames toimunud vene maalikunsti ja Pihkva koolkonna ikoonide näitusest "Pihkva muuseumi aarded" Tallinna Õpetajate majas ja Jaroslavli kunstimuuseumi kunstivarade näituse ettevalmistamisest

  17. Semeinõi albom Jurija Piljara / Svetlana Ragrina

    Index Scriptorium Estoniae

    Ragrina, Svetlana

    2000-01-01

    Artiklis kirjanik Juri Pilar von Pilchaust on juttu ka samasse aadlisuguvõssa kuulunud kunstnik Aleksander Pilarist ja tema loomingust. A. Pilari poeg Boris kinkis isa akvarelli "Eesti" "Vesti" kunstikogule.

  18. Ichthyosis vulgaris

    Science.gov (United States)

    ... abnormal gene from one parent in order to inherit the disease. The condition is often more noticeable in the winter. It may occur along with atopic dermatitis , asthma, keratosis pilaris (small bumps on the back of ...

  19. Semeinõi albom Jurija Piljara / Svetlana Ragrina

    Index Scriptorium Estoniae

    Ragrina, Svetlana

    2000-01-01

    Artiklis kirjanik Juri Pilar von Pilchaust on juttu ka samasse aadlisuguvõssa kuulunud kunstnik Aleksander Pilarist ja tema loomingust. A. Pilari poeg Boris kinkis isa akvarelli "Eesti" "Vesti" kunstikogule.

  20. "Sokrovishtsha mirovogo iskusstva v Tallinne" / Boris Pilar von Pilhau

    Index Scriptorium Estoniae

    Pilar von Pilhau, Boris

    2006-01-01

    Boris Pilari ja Jevgeni Rogovi kunstiprojektist "Maailma kunstiaarded Tallinnas", selle raames toimunud vene maalikunsti ja Pihkva koolkonna ikoonide näitusest "Pihkva muuseumi aarded" Tallinna Õpetajate majas ja Jaroslavli kunstimuuseumi kunstivarade näituse ettevalmistamisest

  1. Etude expérimentale et comparative de la myrmécochorie :le cas des fourmis dispersatrices Lasius niger et Myrmica rubra / Experimental and comparative study of myrmecochory: the case of seed-disperser ants Lasius niger and Myrmica rubra

    OpenAIRE

    Servigne, Pablo

    2008-01-01

    Ce travail porte sur la dispersion des graines par les fourmis et se divise en deux parties :l’une expérimentale (Chapitres 1, 2 & 3) et l’autre synthétique (Chapitres 4 & 5). L’approche expérimentale a consisté en une exploration en conditions de laboratoire des comportements des fourmis à deux étapes du processus de myrmécochorie: à la source de graines et dans le nid. Des graines des plantes myrmécochores Viola odorata et Chelidonium majus ont été présentées aux fourmis Lasius niger et Myr...

  2. PERBEDAAN SKIN CAPACITANCE DAN TRANSEPIDERMAL WATER LOSS PADA KULIT NON-LESI PASIEN PITIRIASIS VERSIKOLOR DENGAN NON-PITIRIASIS VERSIKOLOR

    Directory of Open Access Journals (Sweden)

    Satya Wydya Yenny

    2008-09-01

    Full Text Available AbstrakPada pitiriasis versikolor sering timbul kekambuhan, diduga salah satu penyebabnya adalah kelembaban kulit yang tinggi. Kelembaban kulit dipengaruhi oleh skin capacitance dan transepidermal water loss.Mengetahui skin capacitance dan transepidermal water loss kulit pasien pitiriasis versikolor dan perbedaannya dengan non-pitiriasis versikolor.Penelitian ini merupakan studi potong lintang perbandingan antar kelompok, yang dilakukan pada bulan September sampai dengan Nopember 2004 di Rumah Sakit Dr. Cipto Mangunkusumo. Subyek penelitian pasien pitiriasis versikolor dan kontrol non-pitiriasis versikolor yang dipasangkan dalam hal umur dan jenis kelamin dan dilakukan pemeriksaan skin capacitance dan transepidermal water loss pada kulit yang tampak normal di punggung menggunakan alat Tewameter/Corneometer 350.Dalam kurun waktu tersebut telah diperiksa sebanyak 32 pasien pitiriasis versikolor dan 32 kontrol non-pitiriasis versikolor. Skin capacitance pasien pitiriasis versikolor secara statistik tidak berbeda dengan kontrol non-pitiriasis versikolor (p = 0,730. Transepidermal water loss pasien pitiriasis versikolor secara bermakna lebih rendah dari pada kelompok kontrol non-pitiriasis versikolor (p = 0,000.Tidak ada perbedaan skin capacitance kulit pasien pitiriasis versikolor dengan non-pitiriasis versikolor. Transepidermal water loss kulit pasien pitiriasis versikolor lebih rendah daripada non-pitiriasis versikolor.Kata kunci: pitiriasis versikolor, skin capacitance, transepidermal water lossAbstractThe recurrence of pityriasis versicolor is high, it could be caused by high skin hydration. Skin hydration was influenced by skin capacitance and transepidermal water loss.ARTIKEL PENELITIAN168The purpose of this study was to compare the differences of the skin capacitance and transepidermal water loss between the pityriasis versicolor skin and healthy non-pityriasis versicolor skin.The design of this study was comparative cross-sectional study

  3. Treatment of pityriasis versicolor with itraconazole in combination with butenafine cream and ketoconazole lotion:a clinical study%伊曲康唑联合外用药物治疗花斑糠疹临床研究

    Institute of Scientific and Technical Information of China (English)

    岳喜昂; 刘卫兵; 陈洪晓; 杨华

    2010-01-01

    目的 探讨伊曲康唑胶囊联合1%盐酸布替萘芬乳膏和2%酮康唑洗剂治疗花斑糠疹的疗效及不良反应.方法 入选患者按单双日分为两组,两组均口服伊曲康唑0.2 g,1次/d,连续7 d,同时外用1%盐酸布替萘芬乳膏,1次/d,连续14d,对照组停药观察,试验组同时使用2%酮康唑洗剂洗浴,每周2次,连用3个月.分别于治疗前、治疗后1、3、6、12个月评价疗效.结果 试验组114例患者3个月时痊愈率78.1%,6个月时痊愈率90.4%,对照组125例患者3个月时痊愈率72.8%,6个月时痊愈率75.2%,12个月后试验组复发率1.8%,对照组为18.4%.结论 伊曲康唑胶囊短时口服联合外用布替萘芬和酮康唑洗剂洗浴疗效较好,安全性高,使用方便,可大大降低花斑糠疹的复发率.

  4. Treatment Effect of Naftifine/Ketoconazole Cream to Pityriasis Versicolor in Children%萘替芬酮康唑乳膏治疗儿童花斑糠疹的疗效观察

    Institute of Scientific and Technical Information of China (English)

    熊心猜; 张浩; 丁小洁; 刘婷; 邓利丽; 侯秀芹

    2011-01-01

    目的:观察萘替芬酮康唑乳膏治疗儿童花斑糠疹的疗效及安全性。方法:129例儿童花斑糠疹患儿随机分为两组,治疗组67例,对照组62例,两组在病程、性别、年龄上无统计学差别;治疗组每天外搽萘替芬酮康唑乳膏2次,对照组外搽酮康唑乳膏2次,两组疗程均6周。于治疗前、治疗结束后分别记录患儿皮损情况、真菌检查及有无不良反应。结果:治疗组的有效率为92.54%,对照组的有效率为74.19%,治疗组和对照组比较疗效有统计学差异。治疗组的真菌清除率为98.51%,对照组的真菌清除率为90.32%,治疗组和对照组真菌清除率比较有统计学差异。两组患儿均无明显不良反应发生。结论:萘替芬酮康唑乳膏治疗儿童花斑糠疹安全有效。

  5. 伊曲康唑巩固疗法降低花斑癣复发率的临床研究%A comparative clinical study of the consolidation treatment of itraconazole in pityriasis versicolor

    Institute of Scientific and Technical Information of China (English)

    王亚平; 刘金昌; 刘良传; 滕蔚

    2006-01-01

    目的:探讨一种能够降低花斑癣复发率的有效治疗方案.方法:将初诊的花斑癣患者按就诊时间分为两组,均口服伊曲康唑0.2 g,每日1次,连续服药7 d.7 d后对照组停药观察,试验组则继续服用伊曲康唑,每月口服0.2 g 1次,共6个月.两组患者皆每月复诊1次,共6次.结果:试验组99例患者复发率为1.01%,治愈率为85.86%.对照组95例患者复发率为17.89%,治愈率为64.21%.经卡方检验两组患者的复发率及治愈率相比,差异均有极显著性(x2=16.419 5,P=0.000 1和x2=12.201 3,P=0.0005).结论:巩固治疗方案能在近期内降低花斑癣复发率,同时提高花斑癣的治愈率.

  6. 花斑糠疹和马拉色菌毛囊炎菌种分布特点分析%Distribution of Malassezia species in Pityriasis Versicolor and Malassezia Folliculitis

    Institute of Scientific and Technical Information of China (English)

    李智华; 耿承芳; 江清; 金云; 占萍; 陶丽; 罗云鹏

    2010-01-01

    目的 探讨花宽糠疹和马拉色茵毛囊炎的菌种分布特点.方法 从临床诊断为花斑糠疹和马拉色茵毛囊炎的患者分离培养菌种,通过形态学和生理生化学方法鉴定菌种,并比较两组患者茵种分布情况.结果 共收集花斑糠疹病例161例,培养阳性121株,其中合轴马拉色茵46株,糠秕马拉色茵13株,球形马拉色茵29株,钝性马拉色茵33株;马拉色茵毛囊炎135例,培养阳性114株,其中合轴马拉色茵52株,糠秕马拉色茵43株,球形马拉色茵13株,钝性马拉色茵6株.两种疾病茵种分布差异有显著性(P<0.005).结论 花斑糠疹和马拉色茵毛囊炎茵种分布存在差异,可能为两种疾病不同临床表现的原因之一,但结果尚需慎重解释,需要分子水平的进一步研究.

  7. Observation on Curative Effect of Uigurian Medicine in Treating 610 Cases Suffered from Pityriasis Versicolor alba%维吾尔医治疗白癜风610例的临床观察

    Institute of Scientific and Technical Information of China (English)

    吐尔逊·吾甫尔; 艾尼瓦尔·加马力

    2003-01-01

    目的:初步观察维吾尔医对白癜风疗效;方法:饮食忌口、成熟清除疗法、调节气质、治疗白癜风的专用药物和补药、日光浴和外用药物等作为白癜风的治疗方法;结果:治疗白癜风患者610例,治愈率19.34%,显效36.22%,有效40.98%,无效3.44%.总有效率96.54%.结论:维吾尔医学治疗白癜风有明显的疗效.

  8. Preliminary Study on the Pigmentogenesis of Malassezia in Pityriasis Versicolor%马拉色菌与花斑癣色素改变的相关性初探

    Institute of Scientific and Technical Information of China (English)

    陶诗沁; 陈炜; 杨莉佳; 陈伟; 张海萍; 吕桂霞; 刘维达

    2005-01-01

    目的探讨马拉色菌与花斑癣皮疹色素改变及色氨酸产色三者之间的关系.方法从花斑癣患者皮损分离马拉色菌株,采用国际通用的生化鉴定方法鉴定,然后在不同浓度L-色氨酸的培养基上培养7 d,观察产色反应.结果每个菌种均有产色反应阳性和阴性菌株,产色反应阳性菌株更易引起皮损色素沉着(P<0.005),且产色反应阳性标本颜色按色氨酸浓度递减而变淡.结论菌株的产色反应与马拉色菌的种属分类无必然的联系,色氨酸参与了马拉色菌产色反应.

  9. Comparison of Treatment Effect of Naftifine /Ketoconazole Cream and Clotrimazole Cream to Pityriasis Versicolor%萘替芬酮康唑乳膏与克霉唑乳膏治疗花斑癣的疗效对比

    Institute of Scientific and Technical Information of China (English)

    翟慧娟

    2013-01-01

    目的 分析萘替芬酮康唑乳膏治疗花斑癣患者的疗效.方法 随机将138例花斑癣患者分为两组(实验组72例,对照组66例),两组在性别、年龄、病程上无统计学差异,前组患者涂搽萘替芬酮康唑乳膏,2次/d,后组患者涂搽克霉唑乳膏,2次/d,两组疗程均为6周.分别记录患者的治疗前和治疗结束后真菌检查、皮损情况及不良反应.结果 治疗组的真菌清除率为98.61%,有效率为93.06%;对照组的真菌清除率为90.91%,有效率为72.73%,两组比较疗效有统计学差异(P﹤0.05),两组患者均无明显不良反应.结论 萘替芬酮康唑乳膏治疗花斑糠疹患者安全有效.

  10. Clinical histopathological and ultrastructural manifestations of pityriasis lichenoides et varioliformis acuta%急性痘疮样苔藓样糠疹临床、病理及免疫组化分析

    Institute of Scientific and Technical Information of China (English)

    张红; 笪继平; 王萍; 赵广; 孟如松

    2006-01-01

    目的:探索急性痘疮样苔藓样糠疹(PLEVA)的病因,寻求有效治疗方法.方法:对我院12年中11例PLEVA患者的临床表现、组织病理、免疫组化及超微结构进行回顾性分析.结果:①本组临床表现为全身泛发出血性丘疹为主的多形性皮疹;②组织病理及超微结构:以淋巴细胞性血管炎,淋巴细胞、红细胞游入表皮为特征;③目前治疗以皮质类固醇激素、非甾体抗炎剂、环孢素较为有效.结论:环孢素可能是治疗重症PLEVA的有效药物.

  11. 急性痘疮样苔藓样糠疹1例及文献回顾%One Case with Pityriasis Lichenoides et Varioliformis Acuta and Literature review

    Institute of Scientific and Technical Information of China (English)

    王于斌

    2012-01-01

    患者男,12 岁,躯干、四肢、臀部及腋窝散在分布较多粟粒至黄豆大小暗红色丘疹2 月余,部分丘疹表面附有细碎鳞屑,部分丘疹有脓疱、坏死及结痂,新旧皮疹同时存在.患者无发热及全身浅表淋巴结肿大.组织病理示:表皮灶性坏死,局部基底细胞液化变性,真皮毛细血管周围淋巴细胞浸润.诊断:急性痘疮样苔藓样糠疹.本文从发病机制、临床表现、组织病理、鉴别诊断和治疗等方面进行了文献回顾和复习.

  12. One Case with Pityriasis Lichenoides et Varioliformis Acuta and Literature Review%急性痘疮样苔藓样糠疹1例及文献复习

    Institute of Scientific and Technical Information of China (English)

    孙仁山; 朱堂友; 成琼辉; 伍津津; 吴先林; 李文维

    2010-01-01

    患者男,47岁,躯干、四肢皮肤见泛发粟粒至黄豆大红色斑丘疹20天,丘疹上覆少许稀薄鳞屑,Auspit 征(-),部分皮损中央破溃,坏死、结痂.患者无发热、淋巴结及肝脾肿大.组织病理示:表皮呈灶性变性坏死,区域性淋巴浸润.诊断:急性痘疮样苔藓样糠疹.本文并就其病因、临床表现、病理进展和治疗进行了文献复习.

  13. Optimizing the number of consecutive seed harvests in red fescue (Festuca rubra L.) and perennial ryegrass (Lolium perenne L.) for yield, yield components and economic return

    DEFF Research Database (Denmark)

    Deleuran, Lise Christina; Kristensen, Kristian; Gislum, René;

    2013-01-01

    . The diploid amenity cv. Allegro and forage type cv. Borvi of perennial ryegrass can be harvested in five consecutive years without a significant yield reduction. The tetraploid type cv. Tivoli had the highest thousand seed weight and a significant yield decrease from the first to the second year of seed...

  14. Effect of hydrogel and different types of fertilizers on the number of turf shoots in lawns created by monocultures of red fescue (Festuca rubra L. cultivars and its mixtures

    Directory of Open Access Journals (Sweden)

    Kazimierz Jankowski

    2012-12-01

    Full Text Available In order to determine the effect of the hydrogel content in the soil substrate on the number of shoots per unit area of grass lawns with different proportions of red fescue and monoculture turf produced from the following fescue cultivars: Adio, Libano, Corail, Simone. In the period 2003-2004, a field experiment was carried out in a randomized block design in four replications. In combination with a hydrogel (Aqua-Gel P4, 0.05 kg x m-2 of sorbent was placed at a depth of 10 cm below the soil surface in 2002. Another experimental factor was the type of fertilizer. Trawovit (a fertilizer with standard effects and Sierrablen (a controlled-release fertilizer were used for this purpose. The quantities of fertilizer and time of fertilization date followed manufacturer's instructions. The number of shoots per 1 m2 was determined at the end of the growing season. The study showed that, regardless of years of cultivation, the type of soil substrate and fertilizer, the average number of shoots for the mixtures was about 32% lower than for monoculture lawns. The presence of the hydrogel in the soil substrate regulated soil moisture, and therefore in the mixture lawns the values of the tested features were significantly higher in the treatments with hydrogel. Fertilization with Trawovit, regardless of the type of soil substrate (H, BH, does not lead to a statistically significant difference in the number of shoots between the studied mixtures. However, in the treatments fertilized with Sierrablen, the presence of the hydrogel in the soil substrate caused a significant increase in the traits examined for the mixtures containing, respectively, 20 and 80% of red fescue in their composition. The addition of Aqua-Gel P4 to the soil substrate, when the turf lawns were fertilized with Trawovit, resulted in a significant increase in the number of shoots for the cultivars Adio, Libano and Corail.

  15. 赤芍和白芍本质差异及未来发展的思考%Differences Between Paeoniae Radix Rubra and Paeoniae Radix Alba and Consideration on Future Development

    Institute of Scientific and Technical Information of China (English)

    付晓莹; 孙慧峰; 郭慧敏; 孟祥才

    2016-01-01

    赤芍和白芍药材虽然来源于同一物种芍药Paeonia lactiflora Pall.的相同药用部位,但其药效差异的因素较为复杂,加工方法的不同仅仅足产生药材分化的一个因素.本文从种质、生产方式、环境、采收加工等因素阐述了赤芍和白芍本质差异.芍药野生资源已不能满足临床需要,赤芍来源从野生转为栽培,应确定适宜的种质,优化种植技术,保证传统疗效.

  16. Identification of Fungal Pathogen of Stem Rot of Bayberry (Myrica rubra) and Screening of Fungicides%杨梅腐烂病病原菌鉴定及杀菌剂筛选

    Institute of Scientific and Technical Information of China (English)

    郭立中; 邓先琼

    2006-01-01

    杨梅腐烂病是湖南省杨梅的主要病害之一,该病主要危害杨梅主干分枝处,引起干腐和枝枯.经鉴定,杨梅腐烂病菌为核果壳囊孢菌(Cytospora leucostoma).室内药剂试验结果表明:抑制该菌菌丝生长和分生孢子萌发效果较好的杀菌剂是扑菌特、甲基硫菌灵、多菌灵、退菌特、炭必灵和波尔多液;红杀和湘研植病灵抑制菌丝生长效果较好,但抑制孢子萌发的效果较差;石硫合剂、新万生、疫霜锰锌和敌克松抑制孢子萌发的效果较好,而抑菌丝生长效果较差.

  17. Establishment and Application of S-SAP Molecular Marker System in Chinese Bayberry (Myrica rubra)%杨梅 S-SAP 分子标记体系的建立及应用

    Institute of Scientific and Technical Information of China (English)

    焦云; 舒巧云; 刘珠琴; 章建红

    2016-01-01

    Designed S-SAP markers based on the LTR ( long terminal repeat) sequences of Ty1-copia retrotransposons, used them for DNA profiling of 48 individuals of Chinese bayberry, evaluated the index of polymorphism, constructed a distance tree using clustering with UPGMA, and two-dimensional and three-dimensional plot principal coordinate analysis ( PCO) were performed to analyze the genetic relationship of the Chinese bayberry samples.Successfully obtained amplicons from 18 primer combinations, analyzed yielded an average of 208 fragments per primer combination, adding up to a total of 3739 polymorphic fragments whose sizes ranged from 100 to 500 base pairs ( bp) .The number of markers for each genotype ranged from 98 to 292, and Shannon’ s information index ranged from0 .2041~0.4522.The primer combination JY20 generated a total of 292 bands and was the most polymorphic.Reconstructed a UPGMA tree based on the above-mentioned 18 S-SAP markers, which were further divided into three groups and three subgroups.The cluster analysis and principal coordinate analysis results showed that the acces-sions in the same geographical region were more closely related than those from different regions, and which did not correlate with fruit color, using the three-dimensional plot of the PCO analysis could be more fully and more truly explain the genetic relation-ships of samples.%基于杨梅全基因组Ty1-copia类型逆转座子LTR序列设计开发S-SAP引物组合,利用48份杨梅试材对其多态性指数进行评价,使用UPGMA( Unweighted Pair Group Method with Arithmatic Mean)法,构建了系统聚类树,并进行了二维和三维主坐标分析,进而探讨了杨梅种质资源遗传亲缘关系。成功开发了18个杨梅S-SAP 引物组合,共扩增获得3739个条带,平均每个引物组合可扩增208个条带(100~500 bp),每个引物组合扩增条带数量范围为98~292,Shannon信息指数范围为0.2041~0.4522。其中,引物组合JY20的多态性最高,可扩增出292个条带。基于18个S-SAP引物组合,使用UPGMA法构建所有试材的系统聚类树,结果共分为3个组及3个亚组。聚类分析与主坐标分析结果高度相似,具有相同地域来源的品种大部分被划分于同一个分组,使用聚类分析与主坐标分析所得结果基本一致,但是聚类结果与果实色泽没有明显的关联性,利用三维主坐标分析更能全面且真实地反映杨梅品种间的亲缘关系。

  18. Immobilized Cells Fermentation Using Al-alginate Beads for Red Bayberry(Myrica rubra)Winemaking%杨梅果酒的海藻酸铝固定化发酵研究

    Institute of Scientific and Technical Information of China (English)

    黄国清; 肖仔君; 钟瑞敏; 曾庆孝

    2007-01-01

    杨梅果汁可以用来发酵成杨梅干红果酒,传统的游离发酵杨梅果酒的方式存在着许多不足.为此,本文通过与游离发酵方式进行对比,探讨了海藻酸铝固定化酵母细胞发酵杨梅果酒的方式,并对比了两种发酵方式生产出的杨梅新酒的色泽稳定性.结果表明,杨梅果酒的海藻酸铝固定化酵母细胞发酵最佳工艺参数是发酵温度20℃、海藻酸钠浓度3%(w/v)、氯化钙浓度3%(w/v)、硫酸铝浓度2%(w,v);采用此方法有许多优点,包括珠子可以重复使用、发酵速度比游离发酵方式的更快以及可以得到更好品质的杨梅干红果酒,特别是在花色苷稳定性方面.另外,结果还表明,固定化发酵的杨梅果酒在酒精度、pH值以及总酸方面同游离发酵没有显著差别,但可获得比游离发酵更低的果酒残糖和更高的果酒澄清度.因此,这种固定化发酵方式更适用于杨梅干红果酒的生产.%The red bayberry juice is suitable for winemaking into red dry wine. Traditional fermentation of the wine using free yeast cells fermentation model is more shortage. Al-alginate gel beads immobilized yeast cells fermentation (ICF) for red bayberry winemaking Was carried out by comparing with free yeast cells fermentation (FCF) in present study and the colorant stability of the resultant young wine by FCF and ICF was evaluated. The results showed that the optimal parameter of immobilized yeast fermentation of red bayberry wine were that the continuous fermentation temperature Was at 20℃,sodium alginate concentration Was 3%(w/v),the calcium chloride concentration was 3%(w/v)and aluminum sulfate concentration was 2%(w/v). And ICF have more goodness such as the beads can be reuse for many batches, the fermentation velocity is quicker than FCF, and ICF can result in a red bayberry dry wine with improved quality, especially in the anthocyanin stability. Otherwise, it is shown that there was no difference in alcoholicity, pH and total acidity of resultant young wine between ICF and FCF. But lower residual sugar and higher clarity degree could be obtained in the young wine of ICF. So the ICF model is more available for red bayberry dry wine making.

  19. O espaço gótico em A máscara da morte rubra The gothic spa ce in The masque of the red death

    Directory of Open Access Journals (Sweden)

    Luciana Moura Colucci de Camargo ; Ozíris Borges Filho

    2010-12-01

    Full Text Available Neste trabalho, analisamos o conto de Edgar Allan Poe, A máscara da morterubra, focalizando principalmente a espacialidade. Como suporte teórico,partimos da proposta da Topoanálise, elaborada a partir das ideias de Bachelard,Iuri Lotman, Osman Lins entre outros. Também recorremos ao ensaio de Poe,intitulado Filosofia do mobiliário. Em nossa análise, verificamos que o percursoespacial do texto se divide especialmente pela coordenada da interioridade,revelando-se então em exterior vs. interior. Temos o país como um espaçoenglobante e externo e, como espaço englobado e interior, aparece a abadiapara onde o duque foge com sua corte.In this paper, we analyze the short story The mask of red death by Edgar AllanPoe, focusing primarily on spatiality. As a theoretical starting point, we have theTopoanalysis proposal based on some ideas developed by Bachelard, Lotman,Osman Lins, among others. This paper also turns to Poe’s essay entitled ThePhilosophy of Furniture. In our analysis, we verify that the spatial path of thetext is divided mainly by the coordinate of the interior, revealing outside versus inside. A country as an including and an outward space and, as an enclosed andinterior space is approached by the abbey where the Duke runs away with hiscourt.

  20. Sazonalidade, refrigeração e diferentes tipos de recobrimento na conservação pós-colheita de estacas de cordiline (Cordyline rubra Hügel).

    OpenAIRE

    Nelson Mamoru Sakamoto

    2005-01-01

    O mercado mundial de floricultura gera um fluxo de quase US$ 7bilhões anuais, atualmente concentrado em países como Holanda, Alemanha, Itália, Colômbia, Costa Rica, Equador, Quênia, Tailândia, Malásia, Israel e EUA. O Brasil ainda contribui pouco, aproximadamente 0,3% do total, sendo a participação brasileira concentrada na exportação de mudas, bulbos, flores e folhagens tropicais. O Brasil possui grande potencial exportador de flores e plantas ornamentais através da organização dos produtore...

  1. Effects of Polysaccharide from Nocardia rubra Cell Wall Skeleton on the Proliferation of Mouse Splenic Lymphocytes%N-CWS中多糖的促进小鼠脾淋巴细胞增殖作用

    Institute of Scientific and Technical Information of China (English)

    蔡晶晶; 张少华; 吴梧桐; 叶波平; 张之磊

    2007-01-01

    目的:从红色诺卡氏放线菌细胞壁骨架(N-CWS)中分离筛选新的免疫活性组分.方法:MTT法检测N-CWS中的主要组分对脾淋巴细胞增殖的影响,并对活性组分进行气相色谱分析.结果:在4.5~144 μg·mL-1范围内,N-CWS中的多糖(PS)具有明显的刺激脾淋巴细胞增殖的生物活性,并在9~18 μg·mL-1时刺激作用最强;它是一种主要由阿拉伯糖和半乳糖按照1∶1.66的摩尔比组成的阿拉伯半乳聚糖.结论:N-CWS的抗肿瘤和免疫调节活性主要与其多糖类成分有关.

  2. Nocardia rubra-cell wall skeleton intrapleural injection for malignant pleural effusion%红色诺卡菌细胞壁骨架胸腔注射治疗恶性胸腔积液

    Institute of Scientific and Technical Information of China (English)

    张静; 陈小东; 王赟; 张斯为

    2001-01-01

    目的:观察红色诺卡菌细胞壁骨架(N-CWS)胸腔内注射治疗恶性胸腔积液的临床疗效.方法:60例恶性胸腔积液病人行胸腔闭式引流尽量放尽胸液后分成2组,N-CWS组30例,男性19例,女性11例,年龄62 a±s 11 a,将N-CWS每次400~600 μg溶于氯化钠注射液20 mL,注入胸腔内,qw,连续2次;薏苡仁组30例,男性17例,女性13例,年龄63 a±10 a,将薏苡仁注射液每次100~200 mL,注入胸腔内,qw,连续2次,观察胸腔积液控制效果及其不良反应.结果:N-CWS组有效率为87%,薏苡仁组为57%,2组差异有显著意义(P<0.05).结论:N-CWS治疗恶性胸腔积液效果较薏苡仁注射液佳.

  3. Preparation and Bioactivity of Nocardia rubra Cell Wall Skeleton Capsules%红色诺卡菌细胞壁骨架胶囊的制备及其生物学活性

    Institute of Scientific and Technical Information of China (English)

    张祝兰; 唐文力; 王娟; 杨煌建; 洪金基

    2010-01-01

    目的 制备红色诺卡菌细胞壁骨架(N-CWS)胶囊,并检测其生物学活性.方法 采用超声波法和冷冻干燥法制备N-CWS胶囊,并通过影响因素试验、加速试验及长期试验考察其稳定性,通过小鼠抑瘤试验检测其生物学活性.结果 所制备的N-CWS胶囊各项质量指标均符合相关要求,稳定性良好;口服给药对小鼠移植性肿瘤有明显的抑制作用.结论 本实验制备的N-CWS胶囊质量稳定,抗肿瘤活性强,适于工业化生产.

  4. 酸雨胁迫下比久(B9)对东魁杨梅生理特性的影响%Effects of B9 on Physiological Characteristics in Myrica rubra cv. Dongkui under Acid Rain Stress

    Institute of Scientific and Technical Information of China (English)

    刘建福; 高志远

    2009-01-01

    通过模拟田间试验,研究比久(B9)对酸雨胁迫下6年生东魁杨梅的生理生化特征影响.结果表明:比久能减少酸雨胁迫时丙二醛(MDA)的积累;提高超氧化物歧化酶(SOD)、过氧化物酶(POD)和过氧化氢酶(CAT)活性,减缓膜脂过氧化程度;缓解酸雨胁迫下东魁杨梅叶绿索和类胡萝卜素的降解速度,促进叶片净光合速率的增加,从而提高叶片中可溶性糖和蛋白质含量以及可溶性糖,蛋白质含量的值.但比久处理需要适当的浓度,浓度过高会产生负效应,比久调控的最佳浓度为2500mg/kg左右.

  5. 红色伪角毛虫无性生殖中大核DNA合成的形态学%Macronuclear Morphology of Pseudokeronopsis rubra in the Process of Asexual Reproduction

    Institute of Scientific and Technical Information of China (English)

    张莹; 倪兵; 季玲妹; 顾福康

    2005-01-01

    腹毛类纤毛虫(hypotrich ciliates)是纤毛门原生动物中一个最为进化的类群.迄今的研究表明,这类纤毛虫细胞除具有腹、背的分化,细胞表面纤毛聚集成发达的口纤毛器和体纤毛器外,其另一个典型特征是.细胞内含有一个至多个致密型大核,细胞周期中大核DNA合成采用复制带(replication band)的形式进行.在含一枚大核的纤毛虫细胞中,核的两端同时出现复制带,两条带相向移动至融合后消失,完成DNA复制;在含有两枚至多枚大核的绝大多数种类中,各在核的一端出现复制带,并分别向核的另一端移动,

  6. Experimental evaluation of antifungal and antiseptic agents against Rhodotorula spp.

    Science.gov (United States)

    Preney, L; Théraud, M; Guiguen, C; Gangneux, J P

    2003-12-01

    We studied the susceptibility of 21 strains of Rhodotorula rubra and nine strains of R. glutinis to eight antifungals and tested eight antiseptic agents on one strain of R. rubra. The tested strains were susceptible to ketoconazole, 5-fluorocytosine, amphotericin B, and nystatin, intermediate to econazole and resistant to fluconazole, itraconazole and miconazole. After 5-min contact, six of the eight antiseptic agents tested showed a fungicidal activity on the tested R. rubra strain.

  7. Assessment of allelopathic potential of Cassia sophera L. on ...

    African Journals Online (AJOL)

    ufuoma

    2014-02-26

    Feb 26, 2014 ... resistant weeds and human health problems, make it necessary to ... treatment of pityriasis, psoriasis, asthma, acute bronchitis, cough ... four digital balance of Scientech, Model ZSA 120, Colorado (USA). The leaf area was ...

  8. 苔藓样糠疹

    Institute of Scientific and Technical Information of China (English)

    冯素英; 靳培英

    2009-01-01

    @@ 苔藓样糠疹(pityriasis lichenoides)有三种不同的类型,分别为发热溃疡坏死性苔藓样糠疹(pityriasis lichenoides with ulceronecrotic hyperthermia,PLUH)、急性苔藓痘疮样糠疹(pityriasis lichenoides et varioliformis acuta,PLEVA)、慢性苔藓样糠疹(pityriasis lichenoides chronica,PLC).在三型之间有一些移行状态,分别具有不同亚型的特点,说明这三种亚型之间是有联系的,一些患者可以同时有PLEVA和PLC的皮损表现.

  9. KERATOSIS FOLLICULARIS SPINULOSA DECALVANS: REPORT OF A CASE AND LITERATURE REVIEW

    Directory of Open Access Journals (Sweden)

    P. Mansouri.

    1999-07-01

    Full Text Available Keratosis follicularis spinulosa decalvans (KFSD represents a rare, probably X-linked recessive genodermatosis, characterized by keratosis pilaris of face, trunk and extremities, followed by atrophy, cicatricial alopecia of the scalp, eyebrows and eyelashes, photophobia and corneal abnormalities. We report a rare case of KFSD and review the literature.

  10. Ecological Baseline, Fort Hood, Texas

    Science.gov (United States)

    1980-08-01

    Table 5). Other tree species were Texas oak, netleaf hackberry, live oak, slippery elm (Ulmus rubra), red mulberry ( Morus rubra), Mexican plum (Prunus...included Texas oak, Texas ash, black walnut (Juglans nigra ), and Ashe juniper. Total density was about 760 trees per ha, and basal area was about 27 m

  11. Quantitative analysis of oxyresveratrol in different plant parts of Morus species and related Genera by HPTLC

    Science.gov (United States)

    Four aromatic compounds; oxyresveratrol (1), mulberroside A (2), cudraflavone C (3) and kuwanone J (4) were isolated from the stems of Morus rubra L. The quantitative determination of oxyresveratrol from M. rubra L., M. alba L. and related genera by high performance thin layer chromatography (HPTLC)...

  12. Adoption of parasitic Maculinea alcon caterpillars (Lepidoptera : Lycaenidae) by three Myrmica ant species

    DEFF Research Database (Denmark)

    Als, Thomas Damm; Nash, David Richard; Boomsma, J. J.

    2001-01-01

    Maculinea butterflies are parasites of Myrmica ant nests. The Alcon blue, Maculinea alcon, is unusual in that it parasitizes the nests of several Myrmica species, using M. rubra, M. ruginodis and M. scabrinodis as hosts in different parts of Europe. In Denmark it uses M. rubra and M. ruginodis, b...

  13. Adoption of parasitic Maculinea alcon caterpillars (Lepidoptera : Lycaenidae) by three Myrmica ant species

    DEFF Research Database (Denmark)

    Als, Thomas Damm; Nash, David Richard; Boomsma, J. J.

    2001-01-01

    Maculinea butterflies are parasites of Myrmica ant nests. The Alcon blue, Maculinea alcon, is unusual in that it parasitizes the nests of several Myrmica species, using M. rubra, M. ruginodis and M. scabrinodis as hosts in different parts of Europe. In Denmark it uses M. rubra and M. ruginodis...

  14. CLINICO - MYCOLOGICAL STUDY OF SUPERFICIAL FUNGAL INFECTIONS IN COASTAL KARNATAKA, INDIA

    Directory of Open Access Journals (Sweden)

    Sweta R.

    2013-10-01

    Full Text Available ABSTRACT: Cutaneous fungal infections are common in coastal Karnataka owing to its tropical and humid climate. The organisms causing these infections commonly are dermatophytes, non dermatophytes and yeasts. This study aims to determine the p revalence of cutaneous mycosis, with their different clinical types and etiological agents, and correlate the findings. A total of 96 patients were included in our study, all of them attending dermatology OPD at a tertiary hospital in Mangalore with clinic ally suspected tinea corporis, tinea cruris, tinea pedis, tinea capitis, tinea mannum, onychomycosis, candidiasis and pityriasis versicolor. The study revealed male to female ratio being 0.74:1. The leading diagnosis was pityriasis versicolor, the commones t organism isolated was C. albicans; and the commonest site involved is groin and skin flexures. This study emphasizes utility of timely detection of cutaneous fungal infection in preventing transmission and spread of KEYWORDS: Fungal infe ctions; Dermatophytes; Pityriasis versicolor such infections

  15. Parapsoriasis: a complex issue.

    Science.gov (United States)

    Sehgal, Virendra N; Srivastava, Govind; Aggarwal, Ashok K

    2007-01-01

    Parapsoriasis is a peculiar reaction pattern of the skin that appears to have a spectrum with small plaque parapsoriasis at one end and large plaque at the other. The spectrum between is bridged by pityriasis lichenoides, pityriasis lichenoides chronica, pityriasis lichenoides et varioliformis acuta, and lymphomatoid papulosis. The highlights of the clinical pattern of these diseases has been succinctly elucidated here to facilitate their recognition in day-to-day dermatologic practice. Their possible etiopathogenesis has been brought to focus in the light of changing concepts reported in the literature. Further, possible future implications demand a meticulous follow-up because, in a few cases, true neoplasms may ultimately develop. Treatment modalities are briefly discussed.

  16. Population expansion of some bird species in the city of Wrocław

    Directory of Open Access Journals (Sweden)

    Kopij Grzegorz

    2016-12-01

    Full Text Available During the years 2002-2010, distribution and numbers of eight bird species were studied in the whole city of Wrocław, SW Poland (293 km2. The estimation for these species are as follow: Streptopelia turtur: 3 breeding pairs, Upupa epops: 1, Cuculus canorus: 49, Emberiza hortulana: 7, Luscinia megarhynchos: 214-286, Phoenicurus phoenicurus: 87-118, Turdus pilaris: 105-150, Hippolais icterina: 136-181. In comparison with 1980‘s and 1990’s, a rapid increase in the numbers P. phoenicurus, and T. pilaris, and a slight increase of L. megarhynchos and Cuculus canorus were documented. T. pilaris began to breed in the city in the end of 1990‘s. The increase may indicate that the habitats in Wrocław improved both in regard to food availability, nesting sites and other environmental requisitions. The increase in the numbers recorded for C. canorus, P. phoe-nicurus, and L. megarhynchos may also be a result of good conditions prevailing in their wintering grounds in sub-Saharan Africa.

  17. Identificação de espécies de malassésia na pitiríase versicolor em um serviço de dermatologia do sul do Brasil Identification of Malassezia yeast species isolated from patients with pityriasis versicolor

    Directory of Open Access Journals (Sweden)

    Vanessa Petry

    2011-08-01

    Full Text Available A pitiríase versicolor é uma doença de distribuição universal. Existe a descrição de 12 espécies de malassezia. O objetivo deste estudo foi determinar quais as espécies de malassezia mais prevalentes nos pacientes com pitiríase versicolor. Foram realizadas as coletas através de raspado das lesões nos pacientes com suspeita clínica de pitiríase versicolor e posterior exame micológico e cultural para identificação final da espécie. Foram coletadas amostras de 87 pacientes. Quanto às culturas, 30% foram de Malassezia sympodialis, 25,7% de Malassezia furfur, 22,7% de Malassezia globosa, 12,1% de Malassezia retrita, 7,6% de Malassezia obtusa e 1,5% de Malassezia sloofiae

  18. Clinical Observation of 65 Cases Treated with Naftifine Hydrochloride and Ketoconazole Cream Combined with Adapalene in Pityriasis Versicolor%萘替芬酮康唑乳膏联合阿达帕林凝胶治疗花斑糠疹65例临床观察

    Institute of Scientific and Technical Information of China (English)

    史天威; 任晓坤; 张江安; 余红星; 于建斌

    2014-01-01

    目的 评价萘替芬酮康唑乳膏联合阿达帕林凝胶治疗花斑糠疹的临床疗效及安全性.方法 将入选的65例花斑糠疹患者随机分为2组,治疗组予萘替芬酮康唑乳膏和阿达帕林凝胶外,对照组予萘替芬酮康唑乳膏外用,疗程均为2周,分别于治疗结束时及结束后2周时比较两组患者的真菌清除率及临床疗效.结果 治疗结束时和治疗结束后2周时,治疗组的有效率为84.85%和96.97%,对照组为62.50%和75.00%,差异均有统计学意义(P均<0.05).且两组患者中均未见严重不良反应.结论 萘替芬酮康唑乳膏联合阿达帕林凝胶治疗花斑糠疹疗效较好,二者联合使用对治疗花斑糠疹有协同治疗作用.

  19. A clinical stttdy to treat pityriasis versicolor with the united treatment of itraconazole and local meidication that repel epiphytes%伊曲康唑和局部抗真菌药物(2%酮康唑洗剂)联合治疗花斑癣的临床效果观察

    Institute of Scientific and Technical Information of China (English)

    伍绍萍; 刘健; 伍绍芬; 刘英华; 邹霞

    2008-01-01

    目的 观察伊曲康唑(美扶)胶囊和局部抗真菌药物(2%酮康唑洗剂)联合治疗花斑癣的临床疗效和复发率.方法 选择358例花斑癣患者,随机分成2组,实验组200例,对照组158例.两组均为皮损处外用药(2%酮康唑洗剂),2~3次/d.每周门诊复查1次.实验组加用口服伊曲康唑胶囊200mg,2次/d,共7d,餐中或餐后立即服用,停药3w为一疗程.记录治疗效果及观察不良反应,连续4W后判定结果 .结果 试验组200例,痊愈182例(91%),显效11例(5.5%),有效6例(3%),复发1例(0.5%),总有效率193例(96.5%);对照组158例,痊愈52例(32.91%),显效23例(14.56%),有效54例(34.18%),无效6例(3.80%),总有效率75例(47.47)%,复发23例(14.55%).两组总有效率、复发率比较,差异均具有极显著性(X2=112.758,P<0.005;X2=27.887,P<0.005).结论 伊曲康唑(美扶)和局部抗真菌药物(2%酮康唑洗剂)联合治疗花斑癣,能提高花斑癣治疗的总有效率,同时降低复发率.

  20. 从花斑癣患者的皮损区及非皮损区分离和鉴定马拉色菌%Isolation and Identification of Malassezia Species from Lesional and Non-lesional Sites of Patients with Pityriasis Versicolor

    Institute of Scientific and Technical Information of China (English)

    李志瑜; 冉玉平; 熊琳; 代亚林; 郭晓莉

    2003-01-01

    目的研究花斑癣患者皮损区及非皮损区马拉色菌菌种构成;不同解剖部位、皮损颜色及各菌种的分布情况;患者病情和年龄与菌种构成的关系.方法用无菌胶带粘取113例花斑癣患者皮损区及非皮损区共629个部位的皮屑,分别接种于含菜子油培养基中分离马拉色菌,用生理生化及形态学方法鉴定菌种.结果皮损区与相对应的非皮损区马拉色菌分离阳性率无差别,非皮损区额部和胸背部分离阳性率高于上、下肢.共分离到565株马拉色菌,鉴定出合轴马拉色菌(44.78%)、糠秕马拉色菌(32.94%)、球形马拉色菌(11.68%)、钝形马拉色菌(5.84%)及限制马拉色菌(4.76%)共5个种,有27处(5 01%)同时分离到两种菌.皮损区与非皮损区菌种构成无明显差别,限制马拉色菌主要从额部分离出.菌种构成与皮损面积无关,但与皮损颜色和患者年龄有关.皮损颜色与病程无关.结论花斑癣患者皮损区与非皮损区马拉色菌分离阳性率和菌种构成基本一致,与病情无关,而不同解剖部位、皮损类型及年龄患者的菌种构成有一定差异.

  1. 花斑癣患者血清中抗糠秕马拉色菌IgG、IgM、IgA抗体的检测及其意义%Detection of antibodies for IgG, IgM and IgA classes against whole Malassezia furfur in sera from patients with pityriasis versicolor and its significance

    Institute of Scientific and Technical Information of China (English)

    王群; 吴勤学; 靳培英

    1999-01-01

    目的:探讨机体体液免疫在花斑癣发病中的作用和意义.方法:以糠秕马拉色菌(M.furfur)整菌(WMF)为抗原,用间接酶联免疫吸附试验(ELISA)方法,检测68例花斑癣患者和41例正常人血清中的抗WMF抗体.结果:正常人血清中存在高滴度的抗WMF抗体,花斑癣患者血清中抗WMFIgG抗体明显低于正常对照组(P<0.01),男性患者血清中IgG抗体低于女性患者(P<0.01),病程1年以上者血清中特异的IgG抗体低于病程不到1年者(P<0.01).结论:机体血清抗M.furfur抗体可能是人体内天然抗体,且特异的IgG抗体具有保护作用.支持花斑癣的发病与免疫缺陷有关.

  2. A case report of confluent and reticulated papillomatosis with acanthosis nigricans:easilly confused with pityriasis versicolor%易与花斑糠疹混淆的融合性网状乳头瘤病合并黑棘皮病1例

    Institute of Scientific and Technical Information of China (English)

    文京华; 李伯埙; 黄小平

    2011-01-01

    融合性网状乳头瘤病为一种少见的原因不明的皮肤病,不易诊断.多见于青少年,好发于躯干部和腋窝,为褐色鳞屑性斑片或斑块.临床易误诊而被延误治疗.报告1例融合性网状乳头瘤病合并黑棘皮病,曾被多次拟诊为"花斑糠疹",有较典型的临床表现和组织病理改变.口服及外用异维A酸治疗有效.%Confluent and reticulate papillomatosis (CRP) with unknown etiology is uncommonly happened and easilly misdiagnosed. CRP occurs predominantly in young adults and teenagers with brown scaling patches and plaques affected the upper trunk and axillae. A case of malignant confluent and reticulated papillomatosis with acanthosis nigricans is reported. The patient had typical clinical manifestations and histopathologic changes. Oral and topical administration of isotretinoin showed therapeutic efficiency.

  3. 消银平Ⅰ号合并胸腺肽肠溶片治疗玫瑰糠疹临床疗效观察%An observation of the clinical therapeutic efficacy of pityriasis rosea patients which were treated by Xiao Yin Ping I in concert with Thymopetidum eneric-coated tablets

    Institute of Scientific and Technical Information of China (English)

    燕陶然; 李凤仙

    2012-01-01

    目的:临床观察消银平l号合并胸腺肽肠溶片治疗玫瑰糠疹临床疗效.方法:我们将115例玫瑰糠疹患者随机分为治疗组和对照组进行观察.治疗组A组42例口服消银平I号及胸腺肽肠容片,治疗组B组38例口服消银平I号,对照组C组35例抗组胺治疗.结果:临床验证A组与B组、C组治愈率比较疗效有显著性差异(P<0.05).A组与C组有效率比较疗效有显著性差异(P<0.05).结论:消银平I号合并胸腺肽肠溶片治疗玫瑰糠疹疗效显著.[关健词]玫瑰糠疹;消银平Ⅰ号;胸腺肽肠溶片;抗组胺药

  4. Nocardia rubra-cell wall skeleton preparation in treating malignant pleural effusion by intrapleural injection%胸腔内注射红色诺卡菌细胞壁骨架制剂治疗癌性胸腔积液

    Institute of Scientific and Technical Information of China (English)

    刘淑芹; 陈玉凤; 张媛

    2004-01-01

    目的:评价胸腔内注入红色诺卡菌细胞壁骨架制剂(N-CWS)治疗癌性胸腔积液的临床疗效。方法:56例晚期癌症并发胸腔积液病人尽量排净胸水后,N-CWS 600 μg溶于20 mL氯化钠注射液中胸腔内注入,qw,共1~3次。观察胸水控制情况及不良反应。结果:N-CWS控制胸水治疗总有效率为89 %,主要不良反应为低热11 %(6/56)、胸痛14 %(8/56)。结论:胸腔排液后局部腔内注射N-CWS具有良好的控制胸水作用,不良反应较少。

  5. Effect of nocardia rubra cell wall skeleton on the acti vities of IL-2 and NK cell in syngenic mice bearing bladder carcinoma%N-CWS对小鼠膀胱癌抑癌效应的影响--白细胞介素2水平及自然杀伤细胞活性观察

    Institute of Scientific and Technical Information of China (English)

    崔喆; 李黎明; 吴明明; 虞颂庭

    1999-01-01

    目的:探讨红色诺卡氏菌细胞壁骨架(Nocardia rubr a cell wall skeleton,N-CWS)对膀胱肿瘤的治疗效果及免疫学机制.方法:膀胱癌荷瘤鼠注射N-CWS,观察N-CWS的抑瘤效果及N-CWS对白细胞介素2(IL-2)水平和自然杀伤(NK)细胞活性的影响.结果:注射N-CWS的膀胱癌荷瘤鼠的抑瘤率为96.2%,其IL-2水平及NK细胞活性明显高于肿瘤对照组.结论:N-CWS对膀胱癌具有明显的抑制作用,其机制可能是通过提高机体的IL-2水平和NK细胞活性促进机体的抗肿瘤免疫而实现的.

  6. Studies on the physico-chemical properties, composition and content determination of Nocardia rubra cell wall skeleton%红色诺卡氏菌细胞壁骨架的理化性质、化学成分及含量测定的研究

    Institute of Scientific and Technical Information of China (English)

    张祝兰; 林善; 唐文力; 王清波; 陈君玉; 洪金基

    2002-01-01

    对红色诺卡氏菌细胞壁骨架(N-CWS)的理化性质、化学成分进行研究,并建立其含量测定的方法.采用化学鉴别、光谱分析及比色法.结果表明由红色诺卡氏菌P0-8菌株制备的N-CWS为白色粉末,性质稳定,不溶于水、甲醇等有机溶媒.含有类脂化合物(17.1%)、多糖(阿拉伯半乳聚糖46.3%)、粘肽(主要为丙氨酸、谷氨酸、二氨基庚二酸、葡萄糖胺、胞壁酸);通过比色法测定N-CWS中的阿拉伯糖并推算N-CWS的含量,其重现性较好,小鼠抑瘤活性实验表明N-CWS的含量与活性呈平衡关系.本文建立的测定方法可行.

  7. Evidence-based Danish guidelines for the treatment of Malassezia-related skin diseases

    DEFF Research Database (Denmark)

    Hald, Marianne; Arendrup, Maiken C; Svejgaard, Else L

    2015-01-01

    Internationally approved guidelines for the diagnosis and management of Malassezia-related skin diseases are lacking. Therefore, a panel of experts consisting of dermatologists and a microbiologist under the auspices of the Danish Society of Dermatology undertook a data review and compiled...... guidelines for the diagnostic procedures and management of pityriasis versicolor, seborrhoeic dermatitis and Malassezia folliculitis. Main recommendations in most cases of pityriasis versicolor and seborrhoeic dermatitis include topical treatment which has been shown to be sufficient. As first choice....... Maintenance therapy is often necessary to prevent relapses. In the treatment of Malassezia folliculitis systemic antifungal treatment is probably more effective than topical treatment but a combination may be favourable....

  8. A Clinico - Aetiological Study Of Dermatoses In Paediatric Age Group

    Directory of Open Access Journals (Sweden)

    Ghosh Sadhan K

    1995-01-01

    Full Text Available Five hundred patients of the age group 0-12 years were studied for different types of dermatoses. Pyoderma (35.6%, scabies (22.4% and eczema (17.6% were the most common dermatological conditions, followed by molluscum contagiosum (4.6%, popular urticaria with insect bite (4%, vitiligo (3.4%, miliaria (2.8%, nevus (1.6%. Other dermatoses (8% were pityriasis rosea, wart, chicken pox, herpes zoster, acne vulgaris, leprosy, angular stomatitis, pruritus vulvae, psoriasis, candidiasis, condylomatalata, fixed drug relation, tinea capitis and corporis, phrynoderma, alopecia areata, phimosis, geographic tongue, trichotillomania, canitis, pediculosis, hypertrophic scar and pityriasis versicolor.

  9. Clinicopathological correlation of acquired hypopigmentary disorders

    Directory of Open Access Journals (Sweden)

    Anisha B Patel

    2013-01-01

    Full Text Available Acquired hypopigmentary disorders comprise a significant group of disorders that affect Indians and Asians. The pigment disturbance in darker skin individuals can be very distressing to the patient and the family. These disorders cover a wide array of pathologies including infections, autoimmune processes, lymphoproliferative disorders, and sclerosing diseases. Histological diagnosis is particularly important because treatments for these diseases are varied and specific. This review will focus on histopathological diagnosis based on clinicopathological correlation for commonly encountered disorders such as leprosy, vitiligo, lichen sclerosus, pityriasis alba (PA, and pityriasis versicolor (PV. Atypical or uncommon clinical presentation of classic diseases such as hypopigmented mycosis fungoides (HMF and hypopigmented sarcoidosis are also included.

  10. Historic Resources Assessment, Tennessee-Tombigbee Waterway Wildlife Mitigation Project, Mobile and Tensaw River Deltas, Alabama

    Science.gov (United States)

    1993-03-01

    Quercus nigra ), sugarberry (Celtis laevigata), honey locust (Gleditsia triacanthos), American hornbeam (Carpinus caroliniana), American holly (Ilex opaca...Rhamnus caroliniana), red mulberry ( Morus rubra), and dwarf palmetto (Sabal minor) occur. The transition between the bottomland hardwood forest and the

  11. Archaeological Investigations in the Upper Tombigbee Valley, Mississippi: Phase I. Volume 4.

    Science.gov (United States)

    1983-01-01

    badstraw (Gal ium) blackberries (Rubus) black walnut (Jaglans nigra ) blueberry (Vaccinium-) bottle gourd (Lagenaria siceraria) butternut (Juglans...americana) post oad (Quercus stel lata) pine (Pinus) purselane (Portulaca oleracea) ragweed (Ambrosia) red mulberries ( Morus rubra) sassafras (Sassafras

  12. Environmental Assessment: Land Acquisition at Whiteman Air Force Base, Missouri

    Science.gov (United States)

    2011-06-01

    Quercus alba), and sugar maple (Acer saccharum), while understory species include dogwood (Cornus sp.), red mulberry ( Morus rubra), spicebush (Lindera sp...Salix nigra ), box elder (Acer negundo), broadleaf arrowhead (Sagittaria latifolia), broadleaf cattail (Typha latifolia), spikerush (Eleocharis sp

  13. Red Alder Basal Area, by Stream Reach, for the Pacific Northwest

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Red alder (Alnus rubra) are a common component of forests in Western Oregon and Washington. This file provides an estimate of red alder basal area in western Oregon...

  14. Bioaccumulation of metals from tannery sludge by Typha ...

    African Journals Online (AJOL)

    STORAGESEVER

    2008-09-17

    Sep 17, 2008 ... INTRODUCTION. There are reports on wetland plants like Typha, Phrag- ... treatment unit, the Kasur Tannery Waste Management. Agency (KTWMA) .... All kinds of hydrophytes like floating Azolla rubra, Lemna gibba, Lemna ...

  15. Madagascar Conservation & Development

    African Journals Online (AJOL)

    www.journalmcd.com

    geographical features highlighting their biological and socio- ..... It is expected that people have often to sleep along the banks of the Mandrare until the water level is ...... Activity budgets and activity rhythms in red ruffed lemurs. (Varecia rubra) ...

  16. Final Programmatic Environmental Assessment for Test Area C-74 Complex, Eglin Air Force Base, Florida

    Science.gov (United States)

    2003-08-18

    Sarracenis purpurea Green Anole Anolis carolinensis Red Titi Cyrilla racemiflora Garter Snake Thamnophis sirtalis Tulip Poplar Liriodendrom... Tephrosia mohrii) Eglin’s open canopy Sandhills and upland pine forest Sweet Pitcher Plant (Sarracenia rubra) Wet flatwoods, wet prairies, and baygalls

  17. Prevalence of skin diseases in Varanasi school children

    Directory of Open Access Journals (Sweden)

    Valia A

    1991-01-01

    Full Text Available In a school survey in Varanasi city, 12481 children were examined. More than half (54% had one or more skin diseases. The commonest ones were peduculosis capitis (35%, pityriasis alba (12% acne vulgaris (8%, miliaria (4% and pyodermas (3%

  18. Photosensitivity to selsun shampoo

    Directory of Open Access Journals (Sweden)

    Mani M

    1994-01-01

    Full Text Available A case of photosensitive dermatitis, occurring after the second application of 2.5% selenium sulphide (Selsun shampoo, Abbot, is reported. The shampoo was diluted to half strength with water, before use. The patient had pityriasis versicolor, with extensive lesions on the covered as well as exposed areas.

  19. [Cutaneous Malassezia infections and Malassezia associated dermatoses: An update].

    Science.gov (United States)

    Nenoff, P; Krüger, C; Mayser, P

    2015-06-01

    The lipophilic yeast fungus Malassezia (M.) spp. is the only fungal genus or species which is part of the physiological human microbiome. Today, at least 14 different Malassezia species are known; most of them can only be identified using molecular biological techniques. As a facultative pathogenic microorganism, Malassezia represents the causative agent both of superficial cutaneous infections and of blood stream infections. Pityriasis versicolor is the probably most frequent infection caused by Malassezia. Less common, Malassezia folliculitis occurs. There is only an episodic report on Malassezia-induced onychomycosis. Seborrhoeic dermatitis represents a Malassezia-associated inflammatory dermatosis. In addition, Malassezia allergenes should be considered as the trigger of "Head-Neck"-type atopic dermatitis. Ketoconazole possesses the strongest in vitro activity against Malassezia, and represents the treatment of choice for topical therapy of pityriasis versicolor. Alternatives include other azole antifungals but also the allylamine terbinafine and the hydroxypyridone antifungal agent ciclopirox olamine. "Antiseborrhoeic" agents, e.g. zinc pyrithione, selenium disulfide, and salicylic acid, are also effective in pityriasis versicolor. The drug of choice for oral treatment of pityriasis versicolor is itraconazole; an effective alternative represents fluconazole. Seborrhoeic dermatitis is best treated with topical medication, including topical corticosteroids and antifungal agents like ketoconazole or sertaconazole. Calcineurin inhibitors, e.g. pimecrolimus and tacrolimus, are reliable in seborrhoeic dermatitis, however are used off-label.

  20. Dermatomycoses In Diabetics - A Clinical Study

    Directory of Open Access Journals (Sweden)

    Parthiban K

    1998-01-01

    Full Text Available Two hundred diabetics including 153 non- insulin dependent diabetes mellitus and 47 insulin dependent diabetes mellitus patients, were screened for mycoses. Candidiasis was the commonest mycoses, followed by dermatophtoses and pityriasis versicolor. The fasting blood glucose level was observed to be higher in candidialsis compared to other mycoses.