System of Modelling and Calculation Analysis of Neutron- Physical Experiments at Fast Reactors

International Nuclear Information System (INIS)

Moiseyev, A.V.

2008-01-01

There is an actual task on storage, processing and analysis of the unique experimental data received on power fast reactors for their subsequent use in projects of fast reactors of new (4.) generation. For modeling and carrying out analysis of experiments the integrated computing system MODEXSYS has been developed. In this system the mechanism for consecutive calculation of a fast reactor states with the detailed description of its components is created. The system includes the database describing fast reactor states, results of neutron-physical characteristics measurements at fast reactor, calculation and benchmark models of experiments and calculation results. In system convenient search means and the special graphics shell are provided. It has Interfaces for processing of calculation results and their analysis. MODEXSYS system has been applied for analysis of three types of experiments at fast reactor: k eff , control rod worth and energy release distribution. The most important results of this analysis are described. Application of MODEXSYS system will raise accuracy and reliability of forecasting of fast reactors neutron-physical characteristics; for BN-600 reactor recommended level of accuracy is resulted. (authors)

System of Modelling and Calculation Analysis of Neutron- Physical Experiments at Fast Reactors

Energy Technology Data Exchange (ETDEWEB)

Moiseyev, A.V. [SSC RF - IPPE, 1 Bondarenko Square, Obninsk, Kaluga Region 249033 (Russian Federation)

2008-07-01

There is an actual task on storage, processing and analysis of the unique experimental data received on power fast reactors for their subsequent use in projects of fast reactors of new (4.) generation. For modeling and carrying out analysis of experiments the integrated computing system MODEXSYS has been developed. In this system the mechanism for consecutive calculation of a fast reactor states with the detailed description of its components is created. The system includes the database describing fast reactor states, results of neutron-physical characteristics measurements at fast reactor, calculation and benchmark models of experiments and calculation results. In system convenient search means and the special graphics shell are provided. It has Interfaces for processing of calculation results and their analysis. MODEXSYS system has been applied for analysis of three types of experiments at fast reactor: k{sub eff}, control rod worth and energy release distribution. The most important results of this analysis are described. Application of MODEXSYS system will raise accuracy and reliability of forecasting of fast reactors neutron-physical characteristics; for BN-600 reactor recommended level of accuracy is resulted. (authors)

The Capsicum annuum class IV chitinase ChitIV interacts with receptor-like cytoplasmic protein kinase PIK1 to accelerate PIK1-triggered cell death and defence responses

Science.gov (United States)

Kim, Dae Sung; Kim, Nak Hyun; Hwang, Byung Kook

2015-01-01

The pepper receptor-like cytoplasmic protein kinase, CaPIK1, which mediates signalling of plant cell death and defence responses was previously identified. Here, the identification of a class IV chitinase, CaChitIV, from pepper plants (Capsicum annuum), which interacts with CaPIK1 and promotes CaPIK1-triggered cell death and defence responses, is reported. CaChitIV contains a signal peptide, chitin-binding domain, and glycol hydrolase domain. CaChitIV expression was up-regulated by Xanthomonas campestris pv. vesicatoria (Xcv) infection. Notably, avirulent Xcv infection rapidly induced CaChitIV expression in pepper leaves. Bimolecular fluorescence complementation and co-immunoprecipitation revealed that CaPIK1 interacts with CaChitIV in planta, and that the CaPIK1–CaChitIV complex is localized mainly in the cytoplasm and plasma membrane. CaChitIV is also localized in the endoplasmic reticulum. Transient co-expression of CaChitIV with CaPIK1 enhanced CaPIK1-triggered cell death response and reactive oxygen species (ROS) and nitric oxide (NO) bursts. Co-silencing of both CaChitIV and CaPIK1 in pepper plants conferred enhanced susceptibility to Xcv infection, which was accompanied by a reduced induction of cell death response, ROS and NO bursts, and defence response genes. Ectopic expression of CaPIK1 in Arabidopsis enhanced basal resistance to Hyaloperonospora arabidopsidis infection. Together, the results suggest that CaChitIV positively regulates CaPIK1-triggered cell death and defence responses through its interaction with CaPIK1. PMID:25694549

Physical models and numerical methods of the reactor dynamic computer program RETRAN

International Nuclear Information System (INIS)

Kamelander, G.; Woloch, F.; Sdouz, G.; Koinig, H.

1984-03-01

This report describes the physical models and the numerical methods of the reactor dynamic code RETRAN simulating reactivity transients in Light-Water-Reactors. The neutron-physical part of RETRAN bases on the two-group-diffusion equations which are solved by discretization similar to the TWIGL-method. An exponential transformation is applied and the inner iterations are accelerated by a coarse-mesh-rebalancing procedure. The thermo-hydraulic model approximates the equation of state by a built-in steam-water-table and disposes of options for the calculation of heat-conduction coefficients and heat transfer coefficients. (Author) [de

Nuclear Reactor Physics

Science.gov (United States)

Stacey, Weston M.

2001-02-01

An authoritative textbook and up-to-date professional's guide to basic and advanced principles and practices Nuclear reactors now account for a significant portion of the electrical power generated worldwide. At the same time, the past few decades have seen an ever-increasing number of industrial, medical, military, and research applications for nuclear reactors. Nuclear reactor physics is the core discipline of nuclear engineering, and as the first comprehensive textbook and reference on basic and advanced nuclear reactor physics to appear in a quarter century, this book fills a large gap in the professional literature. Nuclear Reactor Physics is a textbook for students new to the subject, for others who need a basic understanding of how nuclear reactors work, as well as for those who are, or wish to become, specialists in nuclear reactor physics and reactor physics computations. It is also a valuable resource for engineers responsible for the operation of nuclear reactors. Dr. Weston Stacey begins with clear presentations of the basic physical principles, nuclear data, and computational methodology needed to understand both the static and dynamic behaviors of nuclear reactors. This is followed by in-depth discussions of advanced concepts, including extensive treatment of neutron transport computational methods. As an aid to comprehension and quick mastery of computational skills, he provides numerous examples illustrating step-by-step procedures for performing the calculations described and chapter-end problems. Nuclear Reactor Physics is a useful textbook and working reference. It is an excellent self-teaching guide for research scientists, engineers, and technicians involved in industrial, research, and military applications of nuclear reactors, as well as government regulators who wish to increase their understanding of nuclear reactors.

The research reactors their contribution to the reactors physics

International Nuclear Information System (INIS)

Barral, J.C.; Zaetta, A.; Johner, J.; Mathoniere, G.

2000-01-01

The 19 october 2000, the french society of nuclear energy organized a day on the research reactors. This associated report of the technical session, reactors physics, is presented in two parts. The first part deals with the annual meeting and groups general papers on the pressurized water reactors, the fast neutrons reactors and the fusion reactors industry. The second part presents more technical papers about the research programs, critical models, irradiation reactors (OSIRIS and Jules Horowitz) and computing tools. (A.L.B.)

SANA - project results and PIK contributions

Energy Technology Data Exchange (ETDEWEB)

Bellmann, K; Erhard, M; Flechsig, M; Grote, R; Suckow, F

1998-03-01

This report includes the final project results of the two groups at PIK, involved in the project: Firstly, the newly developed physiologically-based forest growth model FORSANA was applied for the first time to three pine stands, which differed largely in their air pollution and deposition history. (The evaluation of the model is presented in PIK Report 32). The model was able to explain the growth during the last decades of at least two of the three stands from the climatic and deposition conditions at the sites. The third site was shown to be exceptional with respect to its relation between dimension and age, and was supposed to be exposed to major disturbances in the past, which could not be accounted for by the model. To extrapolate from the stand level to the regional level, FORSANA was initialised with spatially explicit data from forestry inventory and soil maps. Simulations were executed with measured weather records and regional distributions of deposition and air pollution, which were estimated on the basis of emission inventories and wind directions. Different assumptions about the development of air pollution had been applied to investigate different pollution abatement strategies. The results showed that a positive effect can be expected from the actual emission reductions close the main centres of emission, but showed also that this effect is decreasing with increasing distance from the emission source. (orig./KW)

Reactor Physics

International Nuclear Information System (INIS)

Ait Abderrahim, A.

2002-01-01

SCK-CEN's Reactor Physics and MYRRHA Department offers expertise in various areas of reactor physics, in particular in neutron and gamma calculations, reactor dosimetry, reactor operation and control, reactor code benchmarking and reactor safety calculations. This expertise is applied in the Department's own research projects in the VENUS critical facility, in the BR1 reactor and in the MYRRHA project (this project aims at designing a prototype Accelerator Driven System). Available expertise is also used in programmes external to the Department such as the reactor pressure steel vessel programme, the BR2 materials testing reactor dosimetry, and the preparation and interpretation of irradiation experiments by means of neutron and gamma calculations. The activities of the Fuzzy Logic and Intelligent Technologies in Nuclear Science programme cover several domains outside the department. Progress and achievements in these topical areas in 2001 are summarised

Reactor Physics

Energy Technology Data Exchange (ETDEWEB)

Ait Abderrahim, A

2001-04-01

The Reactor Physics and MYRRHA Department of SCK-CEN offers expertise in various areas of reactor physics, in particular in neutronics calculations, reactor dosimetry, reactor operation, reactor safety and control and non-destructive analysis of reactor fuel. This expertise is applied in the Department's own research projects in the VENUS critical facility, in the BR1 reactor and in the MYRRHA project (this project aims at designing a prototype Accelerator Driven System). Available expertise is also used in programmes external to the Department such as the reactor pressure steel vessel programme, the BR2 reactor dosimetry, and the preparation and interpretation of irradiation experiments by means of neutron and gamma calculations. The activities of the Fuzzy Logic and Intelligent Technologies in Nuclear Science programme cover several domains outside the department. Progress and achievements in these topical areas in 2000 are summarised.

Reactor Physics

International Nuclear Information System (INIS)

Ait Abderrahim, A.

2001-01-01

The Reactor Physics and MYRRHA Department of SCK-CEN offers expertise in various areas of reactor physics, in particular in neutronics calculations, reactor dosimetry, reactor operation, reactor safety and control and non-destructive analysis of reactor fuel. This expertise is applied in the Department's own research projects in the VENUS critical facility, in the BR1 reactor and in the MYRRHA project (this project aims at designing a prototype Accelerator Driven System). Available expertise is also used in programmes external to the Department such as the reactor pressure steel vessel programme, the BR2 reactor dosimetry, and the preparation and interpretation of irradiation experiments by means of neutron and gamma calculations. The activities of the Fuzzy Logic and Intelligent Technologies in Nuclear Science programme cover several domains outside the department. Progress and achievements in these topical areas in 2000 are summarised

Reactor Physics

Energy Technology Data Exchange (ETDEWEB)

Ait Abderrahim, A

2002-04-01

SCK-CEN's Reactor Physics and MYRRHA Department offers expertise in various areas of reactor physics, in particular in neutron and gamma calculations, reactor dosimetry, reactor operation and control, reactor code benchmarking and reactor safety calculations. This expertise is applied in the Department's own research projects in the VENUS critical facility, in the BR1 reactor and in the MYRRHA project (this project aims at designing a prototype Accelerator Driven System). Available expertise is also used in programmes external to the Department such as the reactor pressure steel vessel programme, the BR2 materials testing reactor dosimetry, and the preparation and interpretation of irradiation experiments by means of neutron and gamma calculations. The activities of the Fuzzy Logic and Intelligent Technologies in Nuclear Science programme cover several domains outside the department. Progress and achievements in these topical areas in 2001 are summarised.

Reactor physics

International Nuclear Information System (INIS)

Ait Abderrahim, H.

1998-01-01

Progress in research on reactor physics in 1997 at the Belgian Nuclear Research Centre SCK/CEN is described. Activities in the following four domains are discussed: core physics, ex-core neutron transport, experiments in Materials Testing Reactors, international benchmarks

Reactor Physics Programme

Energy Technology Data Exchange (ETDEWEB)

De Raedt, C

2000-07-01

The Reactor Physics and Department of SCK-CEN offers expertise in various areas of reactor physics, in particular in neutronics calculations, reactor dosimetry, reactor operation, reactor safety and control and non-destructive analysis on reactor fuel. This expertise is applied within the Reactor Physics and MYRRHA Research Department's own research projects in the VENUS critical facility, in the BR1 reactor and in the MYRRHA project (this project aims at designing a prototype Accelerator Driven System). Available expertise is also used in programmes external to the Department such as the reactor pressure steel vessel programme, the BR2 reactor dosimetry, and the preparation and interpretation of irradiation experiments. Progress and achievements in 1999 in the following areas are reported on: (1) investigations on the use of military plutonium in commercial power reactors; (2) neutron and gamma calculations performed for BR-2 and for other reactors; (3) the updating of neutron and gamma cross-section libraries; (4) the implementation of reactor codes; (6) the management of the UNIX workstations; and (6) fuel cycle studies.

Reactor Physics Programme

International Nuclear Information System (INIS)

De Raedt, C.

2000-01-01

The Reactor Physics and Department of SCK-CEN offers expertise in various areas of reactor physics, in particular in neutronics calculations, reactor dosimetry, reactor operation, reactor safety and control and non-destructive analysis on reactor fuel. This expertise is applied within the Reactor Physics and MYRRHA Research Department's own research projects in the VENUS critical facility, in the BR1 reactor and in the MYRRHA project (this project aims at designing a prototype Accelerator Driven System). Available expertise is also used in programmes external to the Department such as the reactor pressure steel vessel programme, the BR2 reactor dosimetry, and the preparation and interpretation of irradiation experiments. Progress and achievements in 1999 in the following areas are reported on: (1) investigations on the use of military plutonium in commercial power reactors; (2) neutron and gamma calculations performed for BR-2 and for other reactors; (3) the updating of neutron and gamma cross-section libraries; (4) the implementation of reactor codes; (6) the management of the UNIX workstations; and (6) fuel cycle studies

A WIMS-NESTLE reactor physics model for an RBMK reactor

International Nuclear Information System (INIS)

Perry, R.T.; Meriwether, G.H.

1996-01-01

This work describes the static neutronic calculations made for a three-dimensional model of an RBMK (Russian) reactor. Future work will involve the use of this neutronic model and a thermal-hydraulic model in coupled calculations. The lattice code, WIMS-D, was used to obtain the cross sections for the static neutronic calculations. The static reactor neutronic calculations were made with NESTLE, a three-dimensional nodal diffusion code. The methods used to establish an RBMK reactor model for use in these codes are discussed, and the cross sections calculated are given

A WIMS-NESTLE reactor physics model for an RBMK reactor

International Nuclear Information System (INIS)

Perry, R.T.; Meriwether, G.H.

1996-01-01

This work describes the static neutronic calculations made for a three-dimensional model of an RBMK (Russian) reactor. Future work will involve the use of this neutronic model and a thermal-hydraulic model in coupled calculations. The lattice code, WIMS-D, was used to obtain the cross sections for the static neutronic calculations. The static reactor neutronic calculations were made with NESTLE, a three-dimensional nodal diffusion code. The methods used to establish an RBMK reactor model for use in these codes are discussed, and the cross sections calculated are given. (author)

Aspirin exerts high anti-cancer activity in PIK3CA-mutant colon cancer cells.

Science.gov (United States)

Gu, Mancang; Nishihara, Reiko; Chen, Yang; Li, Wanwan; Shi, Yan; Masugi, Yohei; Hamada, Tsuyoshi; Kosumi, Keisuke; Liu, Li; da Silva, Annacarolina; Nowak, Jonathan A; Twombly, Tyler; Du, Chunxia; Koh, Hideo; Li, Wenbin; Meyerhardt, Jeffrey A; Wolpin, Brian M; Giannakis, Marios; Aguirre, Andrew J; Bass, Adam J; Drew, David A; Chan, Andrew T; Fuchs, Charles S; Qian, Zhi Rong; Ogino, Shuji

2017-10-20

Evidence suggests that nonsteroidal anti-inflammatory drug aspirin (acetylsalicylic acid) may improve patient survival in PIK3CA -mutant colorectal carcinoma, but not in PIK3CA -wild-type carcinoma. However, whether aspirin directly influences the viability of PIK3CA -mutant colon cancer cells is poorly understood. We conducted in vitro experiments to test our hypothesis that the anti-proliferative activity of aspirin might be stronger for PIK3CA -mutant colon cancer cells than for PIK3CA -wild-type colon cancer cells. We measured the anti-proliferative effect of aspirin at physiologic concentrations in seven PIK3CA -mutant and six PIK3CA -wild-type human colon cancer cell lines. After exposure to aspirin, the apoptotic index and cell cycle phase of colon cancer cells were assessed. In addition, the effect of aspirin was examined in parental SW48 cells and SW48 cell clones with individual knock-in PIK3CA mutations of either c.3140A>G (p.H1047R) or c.1633G>A (p.E545K). Aspirin induced greater dose-dependent loss of cell viability in PIK3CA -mutant cells than in PIK3CA -wild-type cells after treatment for 48 and 72 hours. Aspirin treatment also led to higher proportions of apoptotic cells and G0/G1 phase arrest in PIK3CA -mutant cells than in PIK3CA -wild-type cells. Aspirin treatment of isogenic SW48 cells carrying a PIK3CA mutation, either c.3140A>G (p.H1047R) or c.1633G>A (p. E545K), resulted in a more significant loss of cell viability compared to wild-type controls. Our findings indicate that aspirin causes cell cycle arrest, induces apoptosis, and leads to loss of cell viability more profoundly in PIK3CA -mutated colon cancer cells than in PIK3CA -wild-type colon cancer cells. These findings support the use of aspirin to treat patients with PIK3CA -mutant colon cancer.

Reactor physics of CANFLEX

International Nuclear Information System (INIS)

Sim, K. S.; Min, Byung Joo.

1997-07-01

Characteristic of reactor physics for CANFLEX-NU fuel core were calculated using final fuel design data. The results of analysis showed that there was no impact on reactor operations and safety. The above results of calculations and analysis were described in the physics design for CANFLEX-NU core. Various fuel models were evaluated for selecting high burnup fuel using recovered uranium. It is judged to be worse effects for reactor safety. Hence, the use of graphite within fuel was proposed and its results showed to be better. The analysis system of reactor physics for design and analysis of high burnup fuel was evaluated. Lattice codes and core code were reviewed. From the results, the probability of WIMS-AECL and HELIOS is known to be high for analysis of high burnup fuel. For the core code, RFSP, it was evaluated that the simplified 2 group equation should be replaced by explicit 2 group equation. This report also describes about the status of critical assemblies in other countries. (author). 58 refs., 41 tabs., 126 figs

Compilation of reactor physics data of the year 1984, AVR reactor

International Nuclear Information System (INIS)

Werner, H.; Bergerfurth, A.; Thomas, F.; Geskes, B.

1985-12-01

The 'AVR reactor physics data' is a documentation published once a year, the data presented being obtained by a simulation of reactor operation using the AVR-80 numerical model. This model is constantly updated and improved in response to new results and developments in the field of reactor theory and thermohydraulics, and in response to theoretical or practical modifications of reactor operation or in the computer system. The large variety of measured data available in the AVR reactor simulation system also makes it an ideal testing system for verification of the computing programs presented in the compilation. A survey of the history of operations in 1984 and a short explanation of the computerized simulation methods are followed by tables and graphs that serve as a source of topical data for readers interested in the physics of high-temperature pebble-bed reactors. (orig./HP) [de

Compilation of reactor physics data of the year 1983, AVR reactor

International Nuclear Information System (INIS)

Werner, H.; Bergerfurth, A.; Thomas, F.; Geskes, B.

1985-06-01

The 'AVR reactor physics data' is a documentation published once a year, the data presented being obtained by a simulation of reactor operation using the AVR-80 numerical model. This model is constantly updated and improved in response to new results and developments in the field of reactor theory and thermohydraulics, and in response to theoretical or practical modifications of reactor operation or in the computer system. The large variety of measured data available in the AVR reactor simulation system also makes it an ideal testing system for verification of the computing programs presented in the compilation. A survey of the history of operations in 1983 and a short explanation of the computerized simulation methods are followed by tables and graphs that serve as a source of topical data for readers interested in the physics of high-temperature pebble-bed reactors. (orig./HP) [de

SERPENT Monte Carlo reactor physics code

International Nuclear Information System (INIS)

Leppaenen, J.

2010-01-01

SERPENT is a three-dimensional continuous-energy Monte Carlo reactor physics burnup calculation code, developed at VTT Technical Research Centre of Finland since 2004. The code is specialized in lattice physics applications, but the universe-based geometry description allows transport simulation to be carried out in complicated three-dimensional geometries as well. The suggested applications of SERPENT include generation of homogenized multi-group constants for deterministic reactor simulator calculations, fuel cycle studies involving detailed assembly-level burnup calculations, validation of deterministic lattice transport codes, research reactor applications, educational purposes and demonstration of reactor physics phenomena. The Serpent code has been publicly distributed by the OECD/NEA Data Bank since May 2009 and RSICC in the U. S. since March 2010. The code is being used in some 35 organizations in 20 countries around the world. This paper presents an overview of the methods and capabilities of the Serpent code, with examples in the modelling of WWER-440 reactor physics. (Author)

Reactor physics aspects of CANDU reactors

International Nuclear Information System (INIS)

Critoph, E.

1980-01-01

These four lectures are being given at the Winter Course on Nuclear Physics at Trieste during 1978 February. They constitute part of the third week's lectures in Part II: Reactor Theory and Power Reactors. A physical description of CANDU reactors is given, followed by an overview of CANDU characteristics and some of the design options. Basic lattice physics is discussed in terms of zero energy lattice experiments, irradiation effects and analytical methods. Start-up and commissioning experiments in CANDU reactors are reviewed, and some of the more interesting aspects of operation discussed - fuel management, flux mapping and control of the power distribution. Finally, some of the characteristics of advanced fuel cycles that have been proposed for CANDU reactors are summarized. (author)

Nuclear reactor physics

CERN Document Server

Stacey, Weston M

2010-01-01

Nuclear reactor physics is the core discipline of nuclear engineering. Nuclear reactors now account for a significant portion of the electrical power generated worldwide, and new power reactors with improved fuel cycles are being developed. At the same time, the past few decades have seen an ever-increasing number of industrial, medical, military, and research applications for nuclear reactors. The second edition of this successful comprehensive textbook and reference on basic and advanced nuclear reactor physics has been completely updated, revised and enlarged to include the latest developme

PIK3CA Mutation in Colorectal Cancer: Relationship with Genetic and Epigenetic Alterations

Directory of Open Access Journals (Sweden)

Katsuhiko Nosho

2008-06-01

Full Text Available Somatic PIK3CA mutations are often present in colorectal cancer. Mutant PIK3CA activates AKT signaling, which up-regulates fatty acid synthase (FASN. Microsatellite instability (MSI and CpG island methylator phenotype (CIMP are important molecular classifiers in colorectal cancer. However, the relationship between PIK3CA mutation, MSI and CIMP remains uncertain. Using Pyrosequencing technology, we detected PIK3CA mutations in 91 (15% of 590 population-based colorectal cancers. To determine CIMP status, we quantified DNA methylation in eight CIMP-specific promoters [CACNA1G, CDKN2A (p16, CRABP1, IGF2, MLH1, NEUROG1, RUNX3, and SOCS1] by real-time polymerase chain reaction (MethyLight. PIK3CA mutation was significantly associated with mucinous tumors [P = .0002; odds ratio (OR = 2.44], KRAS mutation (P < .0001; OR = 2.68, CIMP-high (P = .03; OR = 2.08, phospho–ribosomal protein S6 expression (P = .002; OR = 2.19, and FASN expression (P = .02; OR = 1.85 and inversely with p53 expression (P = .01; OR = 0.54 and β-catenin (CTNNB1 alteration (P = .004; OR = 0.43. In addition, PIK3CA G-to-A mutations were associated with MGMT loss (P = .001; OR = 3.24 but not with MGMT promoter methylation. In conclusion, PIK3CA mutation is significantly associated with other key molecular events in colorectal cancer, and MGMT loss likely contributes to the development of PIK3CA G>A mutation. In addition, Pyrosequencing is useful in detecting PIK3CA mutation in archival paraffin tumor tissue. PIK3CA mutational data further emphasize heterogeneity of colorectal cancer at the molecular level.

Reactor physics needs in developing countries

International Nuclear Information System (INIS)

Solanilla, R.

1980-01-01

The aim of this paper the identification of needs on Reactor Physics in developing countries embarked in the installation and later on in the operation of Commercial Nuclear Power Plants. In this context the main task of Reactor Physics should be focused in the application of Physical models with inclusion of thermohydraulic process to solve the various realistic problems which appear to ensure a safe, economical and reliable core design and reactor operation. The first part of the paper deals with the scope of Reactor Physics and its interrelation with other disciplines as seen from the view point of developing countries possibilities. Needs requiring a quick response, i.e., those demands coming during the development of a specific Nuclear Power Plant Project, are summarized in the second part of the lecture. Plant startup has been chosen as reference to separate two categories of requirements: Requirements prior to startup phase include reactor core verification, licensing aspects review and study of fuel utilization alternatives; whereas the period during and after startup mainly embraces codes checkup and normalization, core follow-up and long term prediction

Predictive modeling of coupled multi-physics systems: II. Illustrative application to reactor physics

International Nuclear Information System (INIS)

Cacuci, Dan Gabriel; Badea, Madalina Corina

2014-01-01

Highlights: • We applied the PMCMPS methodology to a paradigm neutron diffusion model. • We underscore the main steps in applying PMCMPS to treat very large coupled systems. • PMCMPS reduces the uncertainties in the optimally predicted responses and model parameters. • PMCMPS is for sequentially treating coupled systems that cannot be treated simultaneously. - Abstract: This work presents paradigm applications to reactor physics of the innovative mathematical methodology for “predictive modeling of coupled multi-physics systems (PMCMPS)” developed by Cacuci (2014). This methodology enables the assimilation of experimental and computational information and computes optimally predicted responses and model parameters with reduced predicted uncertainties, taking fully into account the coupling terms between the multi-physics systems, but using only the computational resources that would be needed to perform predictive modeling on each system separately. The paradigm examples presented in this work are based on a simple neutron diffusion model, chosen so as to enable closed-form solutions with clear physical interpretations. These paradigm examples also illustrate the computational efficiency of the PMCMPS, which enables the assimilation of additional experimental information, with a minimal increase in computational resources, to reduce the uncertainties in predicted responses and best-estimate values for uncertain model parameters, thus illustrating how very large systems can be treated without loss of information in a sequential rather than simultaneous manner

Nuclear reactor physics course for reactor operators

International Nuclear Information System (INIS)

Baeten, P.

2006-01-01

The education and training of nuclear reactor operators is important to guarantee the safe operation of present and future nuclear reactors. Therefore, a course on basic 'Nuclear reactor physics' in the initial and continuous training of reactor operators has proven to be indispensable. In most countries, such training also results from the direct request from the safety authorities to assure the high level of competence of the staff in nuclear reactors. The aim of the basic course on 'Nuclear Reactor Physics for reactor operators' is to provide the reactor operators with a basic understanding of the main concepts relevant to nuclear reactors. Seen the education level of the participants, mathematical derivations are simplified and reduced to a minimum, but not completely eliminated

MicroRNA-375 inhibits colorectal cancer growth by targeting PIK3CA

Energy Technology Data Exchange (ETDEWEB)

Wang, Yihui [Department of Colorectal Surgery, The Third Affiliated Hospital of Harbin Medical University, 150 Haping Road, 150081 Harbin (China); Tang, Qingchao [Cancer Center, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, 150086 Harbin (China); Li, Mingqi; Jiang, Shixiong [Department of Colorectal Surgery, The Third Affiliated Hospital of Harbin Medical University, 150 Haping Road, 150081 Harbin (China); Wang, Xishan, E-mail: wxshan12081@163.com [Cancer Center, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, 150086 Harbin (China)

2014-02-07

Highlights: • miR-375 is downregulated in colorectal cancer cell lines and tissues. • miR-375 inhibits colorectal cancer cell growth by targeting PIK3CA. • miR-375 inhibits colorectal cancer cell growth in xenograft nude mice model. - Abstract: Colorectal cancer (CRC) is the second most common cause of death from cancer. MicroRNAs (miRNAs) represent a class of small non-coding RNAs that control gene expression by triggering RNA degradation or interfering with translation. Aberrant miRNA expression is involved in human disease including cancer. Herein, we showed that miR-375 was frequently down-regulated in human colorectal cancer cell lines and tissues when compared to normal human colon tissues. PIK3CA was identified as a potential miR-375 target by bioinformatics. Overexpression of miR-375 in SW480 and HCT15 cells reduced PIK3CA protein expression. Subsequently, using reporter constructs, we showed that the PIK3CA untranslated region (3′-UTR) carries the directly binding site of miR-375. Additionally, miR-375 suppressed CRC cell proliferation and colony formation and led to cell cycle arrest. Furthermore, miR-375 overexpression resulted in inhibition of phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. SiRNA-mediated silencing of PIK3CA blocked the inhibitory effect of miR-375 on CRC cell growth. Lastly, we found overexpressed miR-375 effectively repressed tumor growth in xenograft animal experiments. Taken together, we propose that overexpression of miR-375 may provide a selective growth inhibition for CRC cells by targeting PI3K/Akt signaling pathway.

Reactors physics. Bases of nuclear physics

International Nuclear Information System (INIS)

Diop, Ch.M.

2006-01-01

The aim of nuclear reactor physics is to quantify the relevant macroscopic data for the characterization of the neutronic state of a reactor core and to evaluate the effects of radiations (neutrons and gamma radiations) on organic matter and on inorganic materials. This first article presents the bases of nuclear physics in the context of nuclear reactors: 1 - reactor physics and nuclear physics; 2 - atomic nucleus - basic definitions: nucleus constituents, dimensions and mass of the atomic nucleus, mass defect, binding energy and stability of the nucleus, strong interaction, nuclear momentums of nucleons and nucleus; 3 - nucleus stability and radioactivity: equation of evolution with time - radioactive decay law; alpha decay, stability limit of spontaneous fission, beta decay, electronic capture, gamma emission, internal conversion, radioactivity, two-body problem and notion of radioactive equilibrium. (J.S.)

Physics of nuclear reactors

International Nuclear Information System (INIS)

Baeten, Peter

2006-01-01

This course gives an introduction to Nuclear Reactor Physics. The first chapter explains the most important parameters and concepts in nuclear reactor physics such as fission, cross sections and the effective multiplication factor. Further on, in the second chapter, the flux distributions in a stationary reactor are derived from the diffusion equation. Reactor kinetics, reactor control and reactor dynamics (feedback effects) are described in the following three chapters. The course concludes with a short description of the different types of existing and future reactors. (author)

Reactor physics and reactor computations

International Nuclear Information System (INIS)

Ronen, Y.; Elias, E.

1994-01-01

Mathematical methods and computer calculations for nuclear and thermonuclear reactor kinetics, reactor physics, neutron transport theory, core lattice parameters, waste treatment by transmutation, breeding, nuclear and thermonuclear fuels are the main interests of the conference

PIK3CA activating mutation in colorectal carcinoma: associations with molecular features and survival.

Directory of Open Access Journals (Sweden)

Christophe Rosty

Full Text Available Mutations in PIK3CA are present in 10 to 15% of colorectal carcinomas. We aimed to examine how PIK3CA mutations relate to other molecular alterations in colorectal carcinoma, to pathologic phenotype and survival. PIK3CA mutation testing was carried out using direct sequencing on 757 incident tumors from the Melbourne Collaborative Cohort Study. The status of O-6-methylguanine-DNA methyltransferase (MGMT was assessed using both immunohistochemistry and methyLight techniques. Microsatellite instability, CpG island phenotype (CIMP, KRAS and BRAF V600E mutation status, and pathology review features were derived from previous reports. PIK3CA mutation was observed in 105 of 757 (14% of carcinomas, characterized by location in the proximal colon (54% vs. 34%; P<0.001 and an increased frequency of KRAS mutation (48% vs. 25%; P<0.001. High-levels of CIMP were more frequently found in PIK3CA-mutated tumors compared with PIK3CA wild-type tumors (22% vs. 11%; P = 0.004. There was no difference in the prevalence of BRAF V600E mutation between these two tumor groups. PIK3CA-mutated tumors were associated with loss of MGMT expression (35% vs. 20%; P = 0.001 and the presence of tumor mucinous differentiation (54% vs. 32%; P<0.001. In patients with wild-type BRAF tumors, PIK3CA mutation was associated with poor survival (HR 1.51 95% CI 1.04-2.19, P = 0.03. In summary, PIK3CA-mutated colorectal carcinomas are more likely to develop in the proximal colon, to demonstrate high levels of CIMP, KRAS mutation and loss of MGMT expression. PIK3CA mutation also contributes to significantly decreased survival for patients with wild-type BRAF tumors.

Substantiation of the TVR-M reactor parameter selection and specific features of the research program

International Nuclear Information System (INIS)

Abov, Yu.G.; Kiselev, G.V.; Shvedov, O.V.

1986-01-01

Comparative analysis of characteristics of the T-VR-M(ITEP, USSR), GRHF(France) and PIK(LNPI USSR) high-flux heavy water cooled and moderated research reactors is given. The TVR-M reactor design concepts are mainly based on a 35-year experience in operating of the first Soviet heavy water research TVR reactor. As a result of the reactor reconstruction its thermal power will increase up to 25 MW neutron flux in experimental channels will increase 10 fold and reach 5.6x10 14 neutron/cm 2 xc. The TVR-M reactor has the quality value the ratio of maximum thermal neutron flux value the reflector to reactor power in practically the same as for the GRHF reactor (2.24x10 13 (neutron/cm 2 xc)/MW) which allows one to place it among the best research reactors in the world. Maximum fuel burnup of the order of 50% and minimum fuel loading are forseen for the TVR-M reactor which provides for operation cost minimum as compared to the GRHF and PIK reactors. The TVR-M reactor practically does not yield to the PIK and GRMF reactors in experimental channel quantity and exceeds the in the number of vertical channels. The TVR-M reactor experimental capabilities allow one to reduce measuring time and provide for conducting the experiments at a qualitatively new level. At the same time capabilities of radioactive nuclide production in qualitative and quantitative senses are increased

The Potsdam Parallel Ice Sheet Model (PISM-PIK) - Part 2: Dynamic equilibrium simulation of the Antarctic ice sheet

Science.gov (United States)

Martin, M. A.; Winkelmann, R.; Haseloff, M.; Albrecht, T.; Bueler, E.; Khroulev, C.; Levermann, A.

2011-09-01

We present a dynamic equilibrium simulation of the ice sheet-shelf system on Antarctica with the Potsdam Parallel Ice Sheet Model (PISM-PIK). The simulation is initialized with present-day conditions for bed topography and ice thickness and then run to steady state with constant present-day surface mass balance. Surface temperature and sub-shelf basal melt distribution are parameterized. Grounding lines and calving fronts are free to evolve, and their modeled equilibrium state is compared to observational data. A physically-motivated calving law based on horizontal spreading rates allows for realistic calving fronts for various types of shelves. Steady-state dynamics including surface velocity and ice flux are analyzed for whole Antarctica and the Ronne-Filchner and Ross ice shelf areas in particular. The results show that the different flow regimes in sheet and shelves, and the transition zone between them, are captured reasonably well, supporting the approach of superposition of SIA and SSA for the representation of fast motion of grounded ice. This approach also leads to a natural emergence of sliding-dominated flow in stream-like features in this new 3-D marine ice sheet model.

p55PIK regulates alpha-fetoprotein expression through the NF-κB signaling pathway.

Science.gov (United States)

Ye, Guoguo; Sun, Ge; Cheng, Zhikui; Zhang, Lei; Hu, Kanghong; Xia, Xianmin; Zhou, Yin

2017-12-15

Alpha-fetoprotein (AFP) is regarded as a diagnostic and prognostic biomarker and a potential therapeutic target for hepatocellular carcinoma (HCC). However, the regulation of AFP expression in HCC remains poorly understood. This study aimed to investigate the mechanism by which AFP expression is regulated by p55PIK, an isoform of PI3K. Human HCC cell lines (HepG2 and Huh-7) were treated with p55PIK specific competitive inhibitor or shRNA, or p55PIK overexpression vector, in the absence or presence of NF-κB inhibitor PDTC. AFP expression was detected by quantitative real-time PCR and Western blotting. NF-κB responsive elements in AFP enhancer region were characterized by luciferase reporter assay. p55PIK significantly stimulated the expression of AFP by activating NF-κB signaling pathway in HCC cells. Furthermore, two NF-κB binding sites in AFP enhancer region were identified to be primarily responsible for p55PIK mediated upregulation of AFP expression. p55PIK/NF-κB signaling plays an important role in the upregulation of AFP expression in HCC. Copyright © 2017 Elsevier Inc. All rights reserved.

Opportunities for reactor scale experimental physics

International Nuclear Information System (INIS)

1999-01-01

A reactor scale tokamak plasma will exhibit three areas of physics phenomenology not accessible by contemporary experimental facilities. These are: (1) instabilities generated by energetic alpha particles; (2) self-heating phenomena; and (3) reactor scale physics, which includes integration of diverse physics phenomena, each with its own scaling properties. In each area, selected examples are presented that demonstrate the importance and uniqueness of physics results from reactor scale facilities for both inductive and steady state reactor options. It is concluded that the physics learned in such investigations will be original physics not attainable with contemporary facilities. In principle, a reactor scale facility could have a good measure of flexibility to optimize the tokamak approach to magnetic fusion energy. (author)

Reactor physics challenges in GEN-IV reactor design

Energy Technology Data Exchange (ETDEWEB)

Driscoll, Michael K.; Hejzlar, Pavel [Massachusetts Institute of Technology, MA (United States)

2005-02-15

An overview of the reactor physics aspects of GENeration Four (GEN-IV) advanced reactors is presented, emphasizing how their special requirements for enhanced sustainability, safety and economics motivates consideration of features not thoroughly analyzed in the past. The resulting concept-specific requirements for better data and methods are surveyed, and some approaches and initiatives are suggested to meet the challenges faced by the international reactor physics community. No unresolvable impediments to successful development of any of the six major types of proposed reactors are identified, given appropriate and timely devotion of resources.

Reactor physics challenges in GEN-IV reactor design

International Nuclear Information System (INIS)

Driscoll, Michael K.; Hejzlar, Pavel

2005-01-01

An overview of the reactor physics aspects of GENeration Four (GEN-IV) advanced reactors is presented, emphasizing how their special requirements for enhanced sustainability, safety and economics motivates consideration of features not thoroughly analyzed in the past. The resulting concept-specific requirements for better data and methods are surveyed, and some approaches and initiatives are suggested to meet the challenges faced by the international reactor physics community. No unresolvable impediments to successful development of any of the six major types of proposed reactors are identified, given appropriate and timely devotion of resources

FGFR3, PIK3CA and RAS mutations in benign lichenoid keratosis.

Science.gov (United States)

Groesser, L; Herschberger, E; Landthaler, M; Hafner, C

2012-04-01

Benign lichenoid keratoses (BLKs) are solitary skin lesions which have been proposed to represent a regressive form of pre-existent epidermal tumours such as solar lentigo or seborrhoeic keratosis. However, the genetic basis of BLK is unknown. FGFR3, PIK3CA and RAS mutations have been shown to be involved in the pathogenesis of seborrhoeic keratosis and solar lentigo. We thus investigated whether these mutations are also present in BLK. After manual microdissection and DNA isolation, 52 BLKs were screened for FGFR3, PIK3CA and RAS hotspot mutations using SNaPshot(®) multiplex assays. We identified 6/52 (12%) FGFR3 mutations, 10/52 (19%) PIK3CA mutations, 6/52 (12%) HRAS mutations and 2/52 (4%) KRAS mutations. FGFR3 and RAS mutations were mutually exclusive. One BLK showed a simultaneous PIK3CA and HRAS mutation. In nine BLKs with a mutation, nonlesional control tissue from the epidermal margin and the dermal lymphocytic infiltrate were wild-type, indicating that these mutations are somatic. To demonstrate that these findings are specific, 10 samples of lichen planus were analysed without evidence for FGFR3, PIK3CA or RAS mutations. Our results indicate that FGFR3, PIK3CA and RAS mutations are present in approximately 50% of BLKs. These findings support the concept on the molecular genetic level that at least a proportion of BLKs represents regressive variants resulting from former benign epidermal tumours such as seborrhoeic keratosis and solar lentigo. © 2011 The Authors. BJD © 2011 British Association of Dermatologists 2011.

Hybrid Reduced Order Modeling Algorithms for Reactor Physics Calculations

Science.gov (United States)

Bang, Youngsuk

hybrid ROM algorithms which can be readily integrated into existing methods and offer higher computational efficiency and defendable accuracy of the reduced models. For example, the snapshots ROM algorithm is hybridized with the range finding algorithm to render reduction in the state space, e.g. the flux in reactor calculations. In another implementation, the perturbation theory used to calculate first order derivatives of responses with respect to parameters is hybridized with a forward sensitivity analysis approach to render reduction in the parameter space. Reduction at the state and parameter spaces can be combined to render further reduction at the interface between different physics codes in a multi-physics model with the accuracy quantified in a similar manner to the single physics case. Although the proposed algorithms are generic in nature, we focus here on radiation transport models used in support of the design and analysis of nuclear reactor cores. In particular, we focus on replacing the traditional assembly calculations by ROM models to facilitate the generation of homogenized cross-sections for downstream core calculations. The implication is that assembly calculations could be done instantaneously therefore precluding the need for the expensive evaluation of the few-group cross-sections for all possible core conditions. Given the generic natures of the algorithms, we make an effort to introduce the material in a general form to allow non-nuclear engineers to benefit from this work.

Proceedings of the 6. National Meeting of Reactor Physics and Thermohydraulic

International Nuclear Information System (INIS)

1986-01-01

The proceedings of the 6. National Meeting of Reactor Physics and Thermohydraulic - 6. ENFIR - allow to evaluate the present status of development in reactor physics and thermohydraulic fields. The mathematical models and methods for calculating neutronic of nuclear reactors, safety reactor analysis, measuring methods of neutronic parameters, computerized simulation of accidents, transients and thermohydraulic analysis are presented. (M.C.K.) [pt

PIK3CA mutations frequently coexist with RAS and BRAF mutations in patients with advanced cancers.

Directory of Open Access Journals (Sweden)

Filip Janku

Full Text Available Oncogenic mutations of PIK3CA, RAS (KRAS, NRAS, and BRAF have been identified in various malignancies, and activate the PI3K/AKT/mTOR and RAS/RAF/MEK pathways, respectively. Both pathways are critical drivers of tumorigenesis.Tumor tissues from 504 patients with diverse cancers referred to the Clinical Center for Targeted Therapy at MD Anderson Cancer Center starting in October 2008 were analyzed for PIK3CA, RAS (KRAS, NRAS, and BRAF mutations using polymerase chain reaction-based DNA sequencing.PIK3CA mutations were found in 54 (11% of 504 patients tested; KRAS in 69 (19% of 367; NRAS in 19 (8% of 225; and BRAF in 31 (9% of 361 patients. PIK3CA mutations were most frequent in squamous cervical (5/14, 36%, uterine (7/28, 25%, breast (6/29, 21%, and colorectal cancers (18/105, 17%; KRAS in pancreatic (5/9, 56%, colorectal (49/97, 51%, and uterine cancers (3/20, 15%; NRAS in melanoma (12/40, 30%, and uterine cancer (2/11, 18%; BRAF in melanoma (23/52, 44%, and colorectal cancer (5/88, 6%. Regardless of histology, KRAS mutations were found in 38% of patients with PIK3CA mutations compared to 16% of patients with wild-type (wtPIK3CA (p = 0.001. In total, RAS (KRAS, NRAS or BRAF mutations were found in 47% of patients with PIK3CA mutations vs. 24% of patients wtPIK3CA (p = 0.001. PIK3CA mutations were found in 28% of patients with KRAS mutations compared to 10% with wtKRAS (p = 0.001 and in 20% of patients with RAS (KRAS, NRAS or BRAF mutations compared to 8% with wtRAS (KRAS, NRAS or wtBRAF (p = 0.001.PIK3CA, RAS (KRAS, NRAS, and BRAF mutations are frequent in diverse tumors. In a wide variety of tumors, PIK3CA mutations coexist with RAS (KRAS, NRAS and BRAF mutations.

Basic concept of common reactor physics code systems. Final report of working party on common reactor physics code systems (CCS)

International Nuclear Information System (INIS)

2004-03-01

A working party was organized for two years (2001-2002) on common reactor physics code systems under the Research Committee on Reactor Physics of JAERI. This final report is compilation of activity of the working party on common reactor physics code systems during two years. Objectives of the working party is to clarify basic concept of common reactor physics code systems to improve convenience of reactor physics code systems for reactor physics researchers in Japan on their various field of research and development activities. We have held four meetings during 2 years, investigated status of reactor physics code systems and innovative software technologies, and discussed basic concept of common reactor physics code systems. (author)

Ernst Julius Öpik's (1916) note on the theory of explosion cratering on the Moon's surface—The complex case of a long-overlooked benchmark paper

Science.gov (United States)

Racki, Grzegorz; Koeberl, Christian; Viik, Tõnu; Jagt-Yazykova, Elena A.; Jagt, John W. M.

2014-10-01

High-velocity impact as a common phenomenon in planetary evolution was ignored until well into the twentieth century, mostly because of inadequate understanding of cratering processes. An eight-page note, published in Russian by the young Ernst Julius Öpik, a great Estonian astronomer, was among the key selenological papers, but due to the language barrier, it was barely known and mostly incorrectly cited. This particular paper is here intended to serve as an explanatory supplement to an English translation of Öpik's article, but also to document an early stage in our understanding of cratering. First, we outline the historical-biographical background of this benchmark paper, and second, a comprehensive discussion of its merits is presented, from past and present perspectives alike. In his theoretical research, Öpik analyzed the explosive formation of craters numerically, albeit in a very simple way. For the first time, he approximated relationships among minimal meteorite size, impact energy, and crater diameter; this scaling focused solely on the gravitational energy of excavating the crater (a "useful" working approach). This initial physical model, with a rational mechanical basis, was developed in a series of papers up to 1961. Öpik should certainly be viewed as the founder of the numerical simulation approach in planetary sciences. In addition, the present note also briefly describes Nikolai A. Morozov as a remarkable man, a forgotten Russian scientist and, surprisingly, the true initiator of Öpik's explosive impact theory. In fact, already between 1909 and 1911, Morozov probably was the first to consider conclusively that explosion craters would be circular, bowl-shaped depressions even when formed under different impact angles.

MiR-124 suppresses cell proliferation in hepatocellular carcinoma by targeting PIK3CA

International Nuclear Information System (INIS)

Lang, Qingbo; Ling, Changquan

2012-01-01

Highlights: ► PIK3CA is a novel target of miR-124 in HepG2 cells. ► MiR-124 suppresses cell proliferation by downregulating PIK3CA expression. ► MiR-124 regulates the PI3K/Akt pathway in HepG2 cells. ► MiR-124 overexpression inhibits the tumorigenesis in nude mice. -- Abstract: MicroRNAs (miRNAs) have crucial roles in the development and progression of human cancers, including hepatocellular carcinoma (HCC). Recent studies have shown that microRNA-124 (miR-124) was downregulated in HCC; however, the underlying mechanisms by which miR-124 suppresses tumorigenesis in HCC are largely unknown. In this study, we report that phosphoinositide 3-kinase catalytic subunit alpha (PIK3CA) is a novel target of miR-124 in HepG2 cells. Overexpression of miR-124 resulted in decreased expression of PIK3CA at both mRNA and protein levels. We found that miR-124 overexpression markedly suppressed cell proliferation by inducing G1-phase cell-cycle arrest in vitro. Consistent with the restoring miR-124 expression, PIK3CA knockdown suppressed cell proliferation, whereas overexpression of PIK3CA abolished the suppressive effect of miR-124. Mechanistic studies showed that miR-124-mediated reduction of PIK3CA resulted in suppression of PI3K/Akt pathway. The expressions of Akt and mTOR, key components of the PI3K/Akt pathway, were all downregulated. Moreover, we found overexpressed miR-124 effectively repressed tumor growth in xenograft animal experiments. Taken together, our results demonstrate that miR-124 functions as a growth-suppressive miRNA and plays an important role in inhibiting the tumorigenesis through targeting PIK3CA.

MiR-124 suppresses cell proliferation in hepatocellular carcinoma by targeting PIK3CA

Energy Technology Data Exchange (ETDEWEB)

Lang, Qingbo [Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433 (China); Ling, Changquan, E-mail: lingchangquan@hotmail.com [Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433 (China)

2012-09-21

Highlights: Black-Right-Pointing-Pointer PIK3CA is a novel target of miR-124 in HepG2 cells. Black-Right-Pointing-Pointer MiR-124 suppresses cell proliferation by downregulating PIK3CA expression. Black-Right-Pointing-Pointer MiR-124 regulates the PI3K/Akt pathway in HepG2 cells. Black-Right-Pointing-Pointer MiR-124 overexpression inhibits the tumorigenesis in nude mice. -- Abstract: MicroRNAs (miRNAs) have crucial roles in the development and progression of human cancers, including hepatocellular carcinoma (HCC). Recent studies have shown that microRNA-124 (miR-124) was downregulated in HCC; however, the underlying mechanisms by which miR-124 suppresses tumorigenesis in HCC are largely unknown. In this study, we report that phosphoinositide 3-kinase catalytic subunit alpha (PIK3CA) is a novel target of miR-124 in HepG2 cells. Overexpression of miR-124 resulted in decreased expression of PIK3CA at both mRNA and protein levels. We found that miR-124 overexpression markedly suppressed cell proliferation by inducing G1-phase cell-cycle arrest in vitro. Consistent with the restoring miR-124 expression, PIK3CA knockdown suppressed cell proliferation, whereas overexpression of PIK3CA abolished the suppressive effect of miR-124. Mechanistic studies showed that miR-124-mediated reduction of PIK3CA resulted in suppression of PI3K/Akt pathway. The expressions of Akt and mTOR, key components of the PI3K/Akt pathway, were all downregulated. Moreover, we found overexpressed miR-124 effectively repressed tumor growth in xenograft animal experiments. Taken together, our results demonstrate that miR-124 functions as a growth-suppressive miRNA and plays an important role in inhibiting the tumorigenesis through targeting PIK3CA.

TU electric reactor model verification

International Nuclear Information System (INIS)

Willingham, C.E.; Killgore, M.R.

1989-01-01

Power reactor benchmark calculations using the code package CASMO-3/SIMULATE-3 have been performed for six cycles of Prairie Island Unit 1. The reload fuel designs for the selected cycles include gadolinia as a burnable absorber, natural uranium axial blankets, and increased water-to-fuel ratio. The calculated results for both low-power physics tests (boron end points, control rod worths, and isothermal temperature coefficients) and full-power operation (power distributions and boron letdown) are compared to measured plant data. These comparisons show that the TU Electric reactor physics models accurately predict important physics parameters for power reactors

Physics and kinetics of TRIGA reactor

International Nuclear Information System (INIS)

Boeck, H.; Villa, M.

2007-01-01

This training module is written as an introduction to reactor physics for reactor operators. It assumes the reader has a basic, fundamental knowledge of physics, materials and mathematics. The objective is to provide enough reactor theory knowledge to safely operate a typical research reactor. At this level, it does not necessarily provide enough information to evaluate the safety aspects of experiment or non-standard operation reviews. The material provides a survey of basic reactor physics and kinetics of TRIGA type reactors. Subjects such as the multiplication factor, reactivity, temperature coefficients, poisoning, delayed neutrons and criticality are discussed in such a manner that even someone not familiar with reactor physics and kinetics can easily follow. A minimum of equations are used and several tables and graphs illustrate the text. (author)

Physiological Levels of Pik3ca H1047R Mutation in the Mouse Mammary Gland Results in Ductal Hyperplasia and Formation of ERα-Positive Tumors

Science.gov (United States)

Tikoo, Anjali; Roh, Vincent; Montgomery, Karen G.; Ivetac, Ivan; Waring, Paul; Pelzer, Rebecca; Hare, Lauren; Shackleton, Mark; Humbert, Patrick; Phillips, Wayne A.

2012-01-01

PIK3CA, the gene coding for the p110α subunit of phosphoinositide 3-kinase, is frequently mutated in a variety of human tumors including breast cancers. To better understand the role of mutant PIK3CA in the initiation and/or progression of breast cancer, we have generated mice with a conditional knock-in of the common activating mutation, Pik3caH1047R, into one allele of the endogenous gene in the mammary gland. These mice developed a ductal anaplasia and hyperplasia by 6 weeks of age characterized by multi-layering of the epithelial lining of the mammary ducts and expansion of the luminal progenitor (Lin−; CD29lo; CD24+; CD61+) cell population. The Pik3caH1047R expressing mice eventually develop mammary tumors with 100% penetrance but with a long latency (>12 months). This is significantly longer than has been reported for transgenic models where expression of the mutant Pik3ca is driven by an exogenous promoter. Histological analysis of the tumors formed revealed predominantly ERα-positive fibroadenomas, carcinosarcomas and sarcomas. In vitro induction of Pik3caH1047R in immortalized mammary epithelial cells also resulted in tumor formation when injected into the mammary fat pad of immunodeficient recipient mice. This novel model, which reproduces the scenario of a heterozygous somatic mutation occurring in the endogenous PIK3CA gene, will thus be a valuable tool for investigating the role of Pik3caH1047R mutation in mammary tumorigenesis both in vivo and in vitro. PMID:22666336

Physiological levels of Pik3ca(H1047R mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors.

Directory of Open Access Journals (Sweden)

Anjali Tikoo

Full Text Available PIK3CA, the gene coding for the p110α subunit of phosphoinositide 3-kinase, is frequently mutated in a variety of human tumors including breast cancers. To better understand the role of mutant PIK3CA in the initiation and/or progression of breast cancer, we have generated mice with a conditional knock-in of the common activating mutation, Pik3ca(H1047R, into one allele of the endogenous gene in the mammary gland. These mice developed a ductal anaplasia and hyperplasia by 6 weeks of age characterized by multi-layering of the epithelial lining of the mammary ducts and expansion of the luminal progenitor (Lin(-; CD29(lo; CD24(+; CD61(+ cell population. The Pik3ca(H1047R expressing mice eventually develop mammary tumors with 100% penetrance but with a long latency (>12 months. This is significantly longer than has been reported for transgenic models where expression of the mutant Pik3ca is driven by an exogenous promoter. Histological analysis of the tumors formed revealed predominantly ERα-positive fibroadenomas, carcinosarcomas and sarcomas. In vitro induction of Pik3ca(H1047R in immortalized mammary epithelial cells also resulted in tumor formation when injected into the mammary fat pad of immunodeficient recipient mice. This novel model, which reproduces the scenario of a heterozygous somatic mutation occurring in the endogenous PIK3CA gene, will thus be a valuable tool for investigating the role of Pik3ca(H1047R mutation in mammary tumorigenesis both in vivo and in vitro.

The Potsdam Parallel Ice Sheet Model (PISM-PIK – Part 2: Dynamic equilibrium simulation of the Antarctic ice sheet

Directory of Open Access Journals (Sweden)

M. A. Martin

2011-09-01

Full Text Available We present a dynamic equilibrium simulation of the ice sheet-shelf system on Antarctica with the Potsdam Parallel Ice Sheet Model (PISM-PIK. The simulation is initialized with present-day conditions for bed topography and ice thickness and then run to steady state with constant present-day surface mass balance. Surface temperature and sub-shelf basal melt distribution are parameterized. Grounding lines and calving fronts are free to evolve, and their modeled equilibrium state is compared to observational data. A physically-motivated calving law based on horizontal spreading rates allows for realistic calving fronts for various types of shelves. Steady-state dynamics including surface velocity and ice flux are analyzed for whole Antarctica and the Ronne-Filchner and Ross ice shelf areas in particular. The results show that the different flow regimes in sheet and shelves, and the transition zone between them, are captured reasonably well, supporting the approach of superposition of SIA and SSA for the representation of fast motion of grounded ice. This approach also leads to a natural emergence of sliding-dominated flow in stream-like features in this new 3-D marine ice sheet model.

Mutation and genomic amplification of the PIK3CA proto-oncogene in pituitary adenomas

International Nuclear Information System (INIS)

Murat, C.B.; Braga, P.B.S.; Fortes, M.A.H.Z.; Bronstein, M.D.; Corrêa-Giannella, M.L.C.; Giorgi, R.R.

2012-01-01

The tumorigenesis of pituitary adenomas is poorly understood. Mutations of the PIK3CA proto-oncogene, which encodes the p110-α catalytic subunit of PI3K, have been reported in various types of human cancers regarding the role of the gene in cell proliferation and survival through activation of the PI3K/Akt signaling pathway. Only one Chinese study described somatic mutations and amplification of the PIK3CA gene in a large series of pituitary adenomas. The aim of the present study was to determine genetic alterations of PIK3CA in a second series that consisted of 33 pituitary adenomas of different subtypes diagnosed by immunohistochemistry: 6 adrenocorticotropic hormone-secreting microadenomas, 5 growth hormone-secreting macroadenomas, 7 prolactin-secreting macroadenomas, and 15 nonfunctioning macroadenomas. Direct sequencing of exons 9 and 20 assessed by qPCR was employed to investigate the presence of mutations and genomic amplification defined as a copy number ≥4. Previously identified PIK3CA mutations (exon 20) were detected in four cases (12.1%). Interestingly, the Chinese study reported mutations only in invasive tumors, while we found a PIK3CA mutation in one noninvasive corticotroph microadenoma. PIK3CA amplification was observed in 21.2% (7/33) of the cases. This study demonstrates the presence of somatic mutations and amplifications of the PIK3CA gene in a second series of pituitary adenomas, corroborating the previously described involvement of the PI3K/Akt signaling pathway in the tumorigenic process of this gland

Mutation and genomic amplification of the PIK3CA proto-oncogene in pituitary adenomas

Energy Technology Data Exchange (ETDEWEB)

Murat, C.B.; Braga, P.B.S.; Fortes, M.A.H.Z. [Laboratório de Endocrinologia Celular e Molecular (LIM-25), Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil); Bronstein, M.D. [Unidade de Neuroendocrinologia, Serviço de Endocrinologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil); Corrêa-Giannella, M.L.C.; Giorgi, R.R. [Laboratório de Endocrinologia Celular e Molecular (LIM-25), Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil)

2012-07-13

The tumorigenesis of pituitary adenomas is poorly understood. Mutations of the PIK3CA proto-oncogene, which encodes the p110-α catalytic subunit of PI3K, have been reported in various types of human cancers regarding the role of the gene in cell proliferation and survival through activation of the PI3K/Akt signaling pathway. Only one Chinese study described somatic mutations and amplification of the PIK3CA gene in a large series of pituitary adenomas. The aim of the present study was to determine genetic alterations of PIK3CA in a second series that consisted of 33 pituitary adenomas of different subtypes diagnosed by immunohistochemistry: 6 adrenocorticotropic hormone-secreting microadenomas, 5 growth hormone-secreting macroadenomas, 7 prolactin-secreting macroadenomas, and 15 nonfunctioning macroadenomas. Direct sequencing of exons 9 and 20 assessed by qPCR was employed to investigate the presence of mutations and genomic amplification defined as a copy number ≥4. Previously identified PIK3CA mutations (exon 20) were detected in four cases (12.1%). Interestingly, the Chinese study reported mutations only in invasive tumors, while we found a PIK3CA mutation in one noninvasive corticotroph microadenoma. PIK3CA amplification was observed in 21.2% (7/33) of the cases. This study demonstrates the presence of somatic mutations and amplifications of the PIK3CA gene in a second series of pituitary adenomas, corroborating the previously described involvement of the PI3K/Akt signaling pathway in the tumorigenic process of this gland.

Modelling aerosol behavior in reactor cooling systems

International Nuclear Information System (INIS)

McDonald, B.H.

1990-01-01

This paper presents an overview of some of the areas of concern in using computer codes to model fission-product aerosol behavior in the reactor cooling system (RCS) of a water-cooled nuclear reactor during a loss-of-coolant accident. The basic physical processes that require modelling include: fission product release and aerosol formation in the reactor core, aerosol transport and deposition in the reactor core and throughout the rest of the RCS, and the interaction between aerosol transport processes and the thermalhydraulics. In addition to these basic physical processes, chemical reactions can have a large influence on the nature of the aerosol and its behavior in the RCS. The focus is on the physics and the implications of numerical methods used in the computer codes to model aerosol behavior in the RCS

Reactor physics problems on HCPWR

International Nuclear Information System (INIS)

Ishiguro, Yukio; Akie, Hiroshi; Kaneko, Kunio; Sasaki, Makoto.

1986-01-01

Reactor physics problems on high conversion pressurized water reactors (HCPWRs) are discussed. Described in this report are outline of the HCPWR, expected accuracy for the various reactor physical qualities, and method for K-effective calculation in the resonance energy area. And requested further research problems are shown. The target value of the conversion ratio are also discussed. (author)

Development of a new physics data library for the SRS reactors

International Nuclear Information System (INIS)

Niemer, K.A.

1993-01-01

The Savannah River Site (SRS) reactors have historically operated at power levels of -2500 MW; thus, previous reactor physics data libraries were created based on that constant power. However, as a result of recent lower power operation, the existing physics data libraries are no longer adequate. Therefore, a new power-dependent physics library was needed to model the reactor at different power levels. The design and development of a new power-dependent physics data library is discussed in this paper

Reactor physics modelling of accident tolerant fuel for LWRs using ANSWERS codes

International Nuclear Information System (INIS)

Lindley, B.A.; Lillington, J.N.; Kotlyar, D.; Parks, G.T.; Petrovic, B.

2016-01-01

adopts an integral configuration and a fully passive decay heat removal system to provide indefinite cooling capability for a class of accidents. This paper presents the equilibrium cycle core design and reactor physics behaviour of the I"2S-LWR with U_3Si_2 and the advanced steel cladding. The results were obtained using the traditional two-stage approach, in which homogenized macroscopic cross-section sets were generated by WIMS and applied in a full 3D core solution with PANTHER. The results obtained with WIMS/PANTHER were compared against the Monte Carlo Serpent code developed by VTT and previously reported results for the I"2S-LWR. The results were found to be in a good agreement (e.g. <200 pcm in reactivity) among the compared codes, giving confidence that the WIMS/PANTHER reactor physics package can be reliably used in modelling advanced LWR systems. (authors)

KRASness and PIK3CAness in patients with advanced colorectal cancer: outcome after treatment with early-phase trials with targeted pathway inhibitors.

Directory of Open Access Journals (Sweden)

Ignacio Garrido-Laguna

Full Text Available To evaluate clinicopathologic and molecular features of patients with metastatic colorectal cancer (mCRC and their outcomes in early-phase trials using pathway-targeting agents.We analyzed characteristics of 238 patients with mCRC referred to the phase 1 trials unit at MD Anderson Cancer Center. KRAS, PIK3CA and BRAF status were tested using PCR-based DNA sequencing.Fifty-one percent of patients harbored KRAS mutations; 15% had PIK3CA mutations. In the multivariate regression model for clinical characteristics KRAS mutations were associated with an increased incidence of lung and bone metastases and decreased incidence of adrenal metastases; PIK3CA mutations were marginally correlated with mucinous tumors (p = 0.05. In the univariate analysis, KRAS and PIK3CA mutations were strongly associated. Advanced Duke's stage (p<0.0001 and KRAS mutations (p = 0.01 were the only significant independent predictors of poor survival (Cox proportional hazards model. Patients with PIK3CA mutations had a trend toward shorter progression-free survival when treated with anti-EGFR therapies (p = 0.07. Eighteen of 78 assessable patients (23% treated with PI3K/Akt/mTOR axis inhibitors achieved stable disease [SD] ≥6 months or complete response/partial response (CR/PR, only one of whom were in the subgroup (N = 15 with PIK3CA mutations, perhaps because 10 of these 15 patients (67% had coexisting KRAS mutations. No SD ≥6 months/CR/PR was observed in the 10 patients treated with mitogen-activating protein kinase (MAPK pathway targeting drugs.KRAS and PIK3CA mutations frequently coexist in patients with colorectal cancer, and are associated with clinical characteristics and outcome. Overcoming resistance may require targeting both pathways.

TRIGA reactor health physics considerations

International Nuclear Information System (INIS)

Johnson, A.G.

1970-01-01

The factors influencing the complexity of a TRIGA health physics program are discussed in details in order to serve as a basis for later consideration of various specific aspects of a typical TRIGA health physics program. The health physics program must be able to provide adequate assistance, control, and safety for individuals ranging from the inexperienced student to the experienced postgraduate researcher. Some of the major aspects discussed are: effluent release and control; reactor area air monitoring; area monitoring; adjacent facilities monitoring; portable instrumentation, personnel monitoring. TRIGA reactors have not been associated with many significant occurrences in the area of health physics, although some operational occurrences have had health physics implications. One specific occurrence at OSU is described involving the detection of non-fission-product radioactive particulates by the continuous air monitor on the reactor top. The studies of this particular situation indicate that most of the particulate activity is coming from the rotating rack and exhausting to the reactor top through the rotating rack loading tube

Particle bed reactor modeling

Science.gov (United States)

Sapyta, Joe; Reid, Hank; Walton, Lew

The topics are presented in viewgraph form and include the following: particle bed reactor (PBR) core cross section; PBR bleed cycle; fuel and moderator flow paths; PBR modeling requirements; characteristics of PBR and nuclear thermal propulsion (NTP) modeling; challenges for PBR and NTP modeling; thermal hydraulic computer codes; capabilities for PBR/reactor application; thermal/hydralic codes; limitations; physical correlations; comparison of predicted friction factor and experimental data; frit pressure drop testing; cold frit mask factor; decay heat flow rate; startup transient simulation; and philosophy of systems modeling.

Compilation of reactor-physical data of the AVR experimental reactor for 1982

International Nuclear Information System (INIS)

Werner, H.; Wawrzik, U.; Grotkamp, T.; Buettgen, I.

1983-12-01

Since the end of 1981 the calculation model AVR-80 has been taken as a basis for compiling reactor-physical data of the AVR experimental reactor. A brief outline of the operation history of 1982 is given, including the beginning of a large-scale experiment dealing with change-over from high enriched uranium to low enriched uranium. Calculations relative to spectral shift, diffusion, temperature, burnup, and recirculation of the fuel elements are described in brief. The essential results of neutron-physical and thermodynamic calculations and the characteristical data of the various types of fuel used are shown in tables and illustrations. (RF) [de

Virtual nuclear reactor for education of nuclear reactor physics

International Nuclear Information System (INIS)

Tsuji, Masashi; Narabayashi, Takashi; Shimazu, Youichiro

2008-01-01

As one of projects that were programmed in the cultivation program for human resources in nuclear engineering sponsored by the Ministry of Economy, Trade and Industry, the development of a virtual reactor for education of nuclear reactor physics started in 2007. The purpose of the virtual nuclear reactor is to make nuclear reactor physics easily understood with aid of visualization. In the first year of this project, the neutron slowing down process was visualized. The data needed for visualization are provided by Monte Carlo calculations; The flights of the respective neutrons generated by nuclear fissions are traced through a reactor core until they disappear by neutron absorption or slow down to a thermal energy. With this visualization and an attached supplement textbook, it is expected that the learners can learn more clearly the physical implication of neutron slowing process that is mathematically described by the Boltzmann neutron transport equation. (author)

Expression of activated PIK3CA in ovarian surface epithelium results in hyperplasia but not tumor formation.

Directory of Open Access Journals (Sweden)

Shun Liang

Full Text Available The Phosphatidylinositol 3'-kinase is a key regulator in various cancer-associated signal transduction pathways. Genetic alterations of its catalytic subunit alpha, PIK3CA, have been identified in ovarian cancer. Our in vivo data suggests that PIK3CA activation is one of the early genetic events in ovarian cancer. However, its role in malignant transformation of ovarian surface epithelium (OSE is largely unclear.Using the Müllerian inhibiting substance type II receptor (MISIIR promoter, we generated transgenic mice that expressed activated PIK3CA in the Müllerian epithelium. Overexpression of PIK3CA in OSE induced remarkable hyperplasia, but was not able to malignantly transform OSE in vivo. The consistent result was also observed in primary cultured OSEs. Although enforced expression of PIK3CA could not induce OSE anchorage-independent growth, it significantly increased anchorage-independent growth of OSE transformed by mutant K-ras.While PIK3CA activation may not be able to initiate OSE transformation, we conclude that activation of PIK3CA may be an important molecular event contributing to the maintenance of OSE transformation initiated by oncogenes such as K-ras.

Analysis of PIK3CA Mutations and Activation Pathways in Triple Negative Breast Cancer.

Directory of Open Access Journals (Sweden)

Paolo Cossu-Rocca

Full Text Available Triple Negative Breast Cancer (TNBC accounts for 12-24% of all breast carcinomas, and shows worse prognosis compared to other breast cancer subtypes. Molecular studies demonstrated that TNBCs are a heterogeneous group of tumors with different clinical and pathologic features, prognosis, genetic-molecular alterations and treatment responsivity. The PI3K/AKT is a major pathway involved in the regulation of cell survival and proliferation, and is the most frequently altered pathway in breast cancer, apparently with different biologic impact on specific cancer subtypes. The most common genetic abnormality is represented by PIK3CA gene activating mutations, with an overall frequency of 20-40%. The aims of our study were to investigate PIK3CA gene mutations on a large series of TNBC, to perform a wider analysis on genetic alterations involving PI3K/AKT and BRAF/RAS/MAPK pathways and to correlate the results with clinical-pathologic data.PIK3CA mutation analysis was performed by using cobas® PIK3CA Mutation Test. EGFR, AKT1, BRAF, and KRAS genes were analyzed by sequencing. Immunohistochemistry was carried out to identify PTEN loss and to investigate for PI3K/AKT pathways components.PIK3CA mutations were detected in 23.7% of TNBC, whereas no mutations were identified in EGFR, AKT1, BRAF, and KRAS genes. Moreover, we observed PTEN loss in 11.3% of tumors. Deregulation of PI3K/AKT pathways was revealed by consistent activation of pAKT and p-p44/42 MAPK in all PIK3CA mutated TNBC.Our data shows that PIK3CA mutations and PI3K/AKT pathway activation are common events in TNBC. A deeper investigation on specific TNBC genomic abnormalities might be helpful in order to select patients who would benefit from current targeted therapy strategies.

Analysis of PIK3CA Mutations and Activation Pathways in Triple Negative Breast Cancer.

Science.gov (United States)

Cossu-Rocca, Paolo; Orrù, Sandra; Muroni, Maria Rosaria; Sanges, Francesca; Sotgiu, Giovanni; Ena, Sara; Pira, Giovanna; Murgia, Luciano; Manca, Alessandra; Uras, Maria Gabriela; Sarobba, Maria Giuseppina; Urru, Silvana; De Miglio, Maria Rosaria

2015-01-01

Triple Negative Breast Cancer (TNBC) accounts for 12-24% of all breast carcinomas, and shows worse prognosis compared to other breast cancer subtypes. Molecular studies demonstrated that TNBCs are a heterogeneous group of tumors with different clinical and pathologic features, prognosis, genetic-molecular alterations and treatment responsivity. The PI3K/AKT is a major pathway involved in the regulation of cell survival and proliferation, and is the most frequently altered pathway in breast cancer, apparently with different biologic impact on specific cancer subtypes. The most common genetic abnormality is represented by PIK3CA gene activating mutations, with an overall frequency of 20-40%. The aims of our study were to investigate PIK3CA gene mutations on a large series of TNBC, to perform a wider analysis on genetic alterations involving PI3K/AKT and BRAF/RAS/MAPK pathways and to correlate the results with clinical-pathologic data. PIK3CA mutation analysis was performed by using cobas® PIK3CA Mutation Test. EGFR, AKT1, BRAF, and KRAS genes were analyzed by sequencing. Immunohistochemistry was carried out to identify PTEN loss and to investigate for PI3K/AKT pathways components. PIK3CA mutations were detected in 23.7% of TNBC, whereas no mutations were identified in EGFR, AKT1, BRAF, and KRAS genes. Moreover, we observed PTEN loss in 11.3% of tumors. Deregulation of PI3K/AKT pathways was revealed by consistent activation of pAKT and p-p44/42 MAPK in all PIK3CA mutated TNBC. Our data shows that PIK3CA mutations and PI3K/AKT pathway activation are common events in TNBC. A deeper investigation on specific TNBC genomic abnormalities might be helpful in order to select patients who would benefit from current targeted therapy strategies.

Nuclear power reactor physics

International Nuclear Information System (INIS)

Barjon, Robert

1975-01-01

The purpose of this book is to explain the physical working conditions of nuclear reactors for the benefit of non-specialized engineers and engineering students. One of the leading ideas of this course is to distinguish between two fundamentally different concepts: - a science which could be called neutrodynamics (as distinct from neutron physics which covers the knowledge of the neutron considered as an elementary particle and the study of its interactions with nuclei); the aim of this science is to study the interaction of the neutron gas with real material media; the introduction will however be restricted to its simplified expression, the theory and equation of diffusion; - a special application: reactor physics, which is introduced when the diffusing and absorbing material medium is also multiplying. For this reason the chapter on fission is used to introduce this section. In practice the section on reactor physics is much longer than that devoted to neutrodynamics and it is developed in what seemed to be the most relevant direction: nuclear power reactors. Every effort was made to meet the following three requirements: to define the physical bases of neutron interaction with different materials, to give a correct mathematical treatment within the limit of necessary simplifying hypotheses clearly explained; to propose, whenever possible, numerical applications in order to fix orders of magnitude [fr

Overview of Experiments for Physics of Fast Reactors from the International Handbooks of Evaluated Criticality Safety Benchmark Experiments and Evaluated Reactor Physics Benchmark Experiments

Energy Technology Data Exchange (ETDEWEB)

Bess, J. D.; Briggs, J. B.; Gulliford, J.; Ivanova, T.; Rozhikhin, E. V.; Semenov, M. Yu.; Tsibulya, A. M.; Koscheev, V. N.

2017-07-01

Overview of Experiments to Study the Physics of Fast Reactors Represented in the International Directories of Critical and Reactor Experiments John D. Bess Idaho National Laboratory Jim Gulliford, Tatiana Ivanova Nuclear Energy Agency of the Organisation for Economic Cooperation and Development E.V.Rozhikhin, M.Yu.Sem?nov, A.M.Tsibulya Institute of Physics and Power Engineering The study the physics of fast reactors traditionally used the experiments presented in the manual labor of the Working Group on Evaluation of sections CSEWG (ENDF-202) issued by the Brookhaven National Laboratory in 1974. This handbook presents simplified homogeneous model experiments with relevant experimental data, as amended. The Nuclear Energy Agency of the Organization for Economic Cooperation and Development coordinates the activities of two international projects on the collection, evaluation and documentation of experimental data - the International Project on the assessment of critical experiments (1994) and the International Project on the assessment of reactor experiments (since 2005). The result of the activities of these projects are replenished every year, an international directory of critical (ICSBEP Handbook) and reactor (IRPhEP Handbook) experiments. The handbooks present detailed models of experiments with minimal amendments. Such models are of particular interest in terms of the settlements modern programs. The directories contain a large number of experiments which are suitable for the study of physics of fast reactors. Many of these experiments were performed at specialized critical stands, such as BFS (Russia), ZPR and ZPPR (USA), the ZEBRA (UK) and the experimental reactor JOYO (Japan), FFTF (USA). Other experiments, such as compact metal assembly, is also of interest in terms of the physics of fast reactors, they have been carried out on the universal critical stands in Russian institutes (VNIITF and VNIIEF) and the US (LANL, LLNL, and others.). Also worth mentioning

Physical measurements in Marcoule reactors (1962)

International Nuclear Information System (INIS)

Teste du Bailler, A.

1962-01-01

A brief description of the physical measurements in Marcoule reactors is given here. During commissioning and subsequent years of operation, various experiments ha been carried out to check design data, and improve the operating conditions and also test theoretical models for kinetic studies. (author) [fr

Advances in U.S. reactor physics standards

International Nuclear Information System (INIS)

Cokinos, Dimitrios

2008-01-01

The standards for Reactor Design, widely used in the nuclear industry, provide guidance and criteria for performing and validating a wide range of nuclear reactor calculations and measurements. Advances, over the past decades in reactor technology, nuclear data and infrastructure in the data handling field, led to major improvements in the development and application of reactor physics standards. A wide variety of reactor physics methods and techniques are being used by reactor physicists for the design and analysis of modern reactors. ANSI (American National Standards Institute) reactor physics standards, covering such areas as nuclear data, reactor design, startup testing, decay heat and fast neutron fluence in the pressure vessel, are summarized and discussed. These standards are regularly undergoing review to respond to an evolving nuclear technology and are being successfully used in the U.S and abroad contributing to improvements in reactor design, safe operation and quality assurance. An overview of the overall program of reactor physics standards is presented. New standards currently under development are also discussed. (authors)

Current tendencies and perspectives of development research reactors of Russia

International Nuclear Information System (INIS)

Gabaraev, B.A.; Kchmelschikov, V.V.

2004-01-01

; - reactor PIK, satisfying Russian and foreign requirements for beam experiments in the range of nuclear physics, condensed matter physics and other fundamental investigations; - pulsed reactors; - eventually, ADS draw growing attention lately; these plants can compete with RR as neutron sources for some task solutions. In the report the results of new engineering developments by the designs of reactors under reconstruction and modernization are presented, as well as the results for experimental arrangements of different purposes for these reactors: - IREN; - Steam-water loop PVP-3 (reactor MIR.M1); - Medical channel for BNCT (reactor IRT, MEPhI). Problem of selection of high-powered universal Research Reactor type and design of next generation also exists in the face of Russian experts. They have 5-10 years to solve this problem. Russia is ready for cooperation in the field of development, construction and utilization in future of new research reactor, which can be built in Europe instead of decommissioned ones

Physics of high-temperature reactors

International Nuclear Information System (INIS)

Massimo, L.

1976-01-01

The subject is covered in chapters entitled: general description of the HTR core; general considerations about reactor physics; neutron cross-sections; basic aspects of transport and diffusion theory; methods for the solution of the diffusion equation; slowing-down and thermalization in graphite; resonance absorption; spectrum calculations and cross-section averaging; burn-up; core design; fuel management and cost calculations; temperature coefficient; core dynamics and accident analysis; reactor control; peculiarities of HTR physics; analysis of calculational accuracy; sequence of reactor design calculations. (U.K.)

Research on reactor physics data

International Nuclear Information System (INIS)

1961-01-01

In the early years of nuclear reactor research, each national program tended to develop its own reactor physics information. The Government of Norway proposed to the Agency the undertaking of a joint program in reactor physics utilizing the facilities and staff of its zero power reactor NORA then under construction. Following the approval by the Board of Governors in February, the Agency invited Member States to submit the names and qualifications of scientists they wished to suggest for the project. All the results and information gained through the program, which is expected to last about three years, will be placed at the disposal of the Agency's Member States

Once-through CANDU reactor models for the ORIGEN2 computer code

International Nuclear Information System (INIS)

Croff, A.G.; Bjerke, M.A.

1980-11-01

Reactor physics calculations have led to the development of two CANDU reactor models for the ORIGEN2 computer code. The model CANDUs are based on (1) the existing once-through fuel cycle with feed comprised of natural uranium and (2) a projected slightly enriched (1.2 wt % 235 U) fuel cycle. The reactor models are based on cross sections taken directly from the reactor physics codes. Descriptions of the reactor models, as well as values for the ORIGEN2 flux parameters THERM, RES, and FAST, are given

PIK3CA expression in diffuse large B cell lymphoma tissue and the effect of its knockdown in vitro

Directory of Open Access Journals (Sweden)

Cui W

2017-04-01

Full Text Available Wenli Cui,1–4,* Shutao Zheng,5,6,* Zebing Liu,1–3 Weige Wang,1–3 Ying Cai,1–3 Rui Bi,1–3 Bing Cao,1–3 Xiaoyan Zhou1–3 1Department of Pathology, Shanghai Cancer Center, Fudan University, 2Department of Oncology, Shanghai Medical College, Fudan University, 3Institute of Pathology, Fudan University, Shanghai, 4Department of Pathology, The First Affiliated Hospital of Xinjiang Medical University, 5Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, 6State Key Lab Incubation Base of Xinjiang Major Diseases Research, First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi, People’s Republic of China *These authors contributed equally to this work Abstract: PIK3CA has been extensively investigated from its molecular mechanism perspective and epidemiological association with its mutations in different types of cancers. However, little has been reported regarding the clinicopathological significance of PIK3CA expression in diffuse large B cell lymphoma (DLBCL. In the present study, we investigated the clinicopathological significance of PIK3CA in DLBCL by performing immunohistochemical evaluation of PIK3CA in tissue microarrays consisting of 199 cases of DLBCL. Kaplan–Meier survival analysis was performed to analyze the association between PIK3CA expression and overall prognosis. To further investigate the role of PIK3CA mediated in the proliferation, cell cycle and apoptosis of DLBCL cells, Cell Counting Kit-8 (CCK-8 and flow cytometry assays were carried out in DLBCL cell lines after successful, stable knockdown of PIK3CA using lentiviral short hairpin RNA inference. Our results indicated that although PIK3CA was shown to be extensively expressed in DLBCL, no significant association was observed between PIK3CA expression and clinical outcome or between PIK3CA expression and other clinicopathological parameters, except between performance state (PS

Sensitivity and Uncertainty Analysis of Coupled Reactor Physics Problems : Method Development for Multi-Physics in Reactors

NARCIS (Netherlands)

Perkó, Z.

2015-01-01

This thesis presents novel adjoint and spectral methods for the sensitivity and uncertainty (S&U) analysis of multi-physics problems encountered in the field of reactor physics. The first part focuses on the steady state of reactors and extends the adjoint sensitivity analysis methods well

Standards for reference reactor physics measurements

International Nuclear Information System (INIS)

Harris, D.R.; Cokinos, D.M.; Uotinen, V.

1990-01-01

Reactor physics analysis methods require experimental testing and confirmation over the range of practical reactor configurations and states. This range is somewhat limited by practical fuel types such as actinide oxides or carbides enclosed in metal cladding. On the other hand, this range continues to broaden because of the trend of using higher enrichment, if only slightly enriched, electric utility fuel. The need for experimental testing of the reactor physics analysis methods arises in part because of the continual broadening of the range of core designs, and in part because of the nature of the analysis methods. Reactor physics analyses are directed primarily at the determination of core reactivities and reaction rates, the former largely for reasons of reactor control, and the latter largely to ensure that material limitations are not violated. Errors in these analyses can be regarded as being from numerics, from the data base, and from human factors. For numerical, data base, and human factor reasons, then, it is prudent and customary to qualify reactor physical analysis methods against experiments. These experiments can be treated as being at low power or at high power, and each of these types is subject to an American National Standards Institute standard. The purpose of these standards is to aid in improving and maintaining adequate quality in reactor physics methods, and it is from this point of view that the standards are examined here

Impacts on power reactor health physics programs

International Nuclear Information System (INIS)

Meyer, B.A.

1991-01-01

The impacts on power reactor health physics programs form implementing the revised 10 CFR Part 20 will be extensive and costly. Every policy, program, procedure and training lesson plan involving health physics will require changes and the subsequent retraining of personnel. At each power reactor facility, hundreds of procedures and thousands of people will be affected by these changes. Every area of a power reactor health physics program will be affected. These areas include; ALARA, Respiratory Protection, Exposure Control, Job Coverage, Dosimetry, Radwaste, Effluent Accountability, Emergency Planning and Radiation Worker Training. This paper presents how power reactor facilities will go about making these changes and gives possible examples of some of these changes and their impact on each area of power reactor health physics program

The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer.

Directory of Open Access Journals (Sweden)

Jatin Roper

Full Text Available To examine the in vitro and in vivo efficacy of the dual PI3K/mTOR inhibitor NVP-BEZ235 in treatment of PIK3CA wild-type colorectal cancer (CRC.PIK3CA mutant and wild-type human CRC cell lines were treated in vitro with NVP-BEZ235, and the resulting effects on proliferation, apoptosis, and signaling were assessed. Colonic tumors from a genetically engineered mouse (GEM model for sporadic wild-type PIK3CA CRC were treated in vivo with NVP-BEZ235. The resulting effects on macroscopic tumor growth/regression, proliferation, apoptosis, angiogenesis, and signaling were examined.In vitro treatment of CRC cell lines with NVP-BEZ235 resulted in transient PI3K blockade, sustained decreases in mTORC1/mTORC2 signaling, and a corresponding decrease in cell viability (median IC(50 = 9.0-14.3 nM. Similar effects were seen in paired isogenic CRC cell lines that differed only in the presence or absence of an activating PIK3CA mutant allele. In vivo treatment of colonic tumor-bearing mice with NVP-BEZ235 resulted in transient PI3K inhibition and sustained blockade of mTORC1/mTORC2 signaling. Longitudinal tumor surveillance by optical colonoscopy demonstrated a 97% increase in tumor size in control mice (p = 0.01 vs. a 43% decrease (p = 0.008 in treated mice. Ex vivo analysis of the NVP-BEZ235-treated tumors demonstrated a 56% decrease in proliferation (p = 0.003, no effects on apoptosis, and a 75% reduction in angiogenesis (p = 0.013.These studies provide the preclinical rationale for studies examining the efficacy of the dual PI3K/mTOR inhibitor NVP-BEZ235 in treatment of PIK3CA wild-type CRC.

Reactor physics for non-nuclear engineers

International Nuclear Information System (INIS)

Lewis, E.E.

2011-01-01

A one-term undergraduate course in reactor physics is described. The instructional format is strongly influenced by its intended audience of non-nuclear engineering students. In contrast to legacy treatments of the subject, the course focuses on the physics of nuclear power reactors with no attempt to include instruction in numerical methods. The multi-physics of power reactors is emphasized highlighting the close interactions between neutronic and thermal phenomena in design and analysis. Consequently, the material's sequencing also differs from traditional treatments, for example treating kinetics before the neutron diffusion is introduced. (author)

An integrative genomic and proteomic analysis of PIK3CA, PTEN and AKT mutations in breast cancer

Energy Technology Data Exchange (ETDEWEB)

Stemke-Hale, Katherine; Gonzalez-Angulo, Ana Maria; Lluch, Ana; Neve, Richard M.; Kuo, Wen-Lin; Davies, Michael; Carey, Mark; Hu, Zhi; Guan, Yinghui; Sahin, Aysegul; Symmans, W. Fraser; Pusztai, Lajos; Nolden, Laura K.; Horlings, Hugo; Berns, Katrien; Hung, Mien-Chie; van de Vijver, Marc J.; Valero, Vicente; Gray, Joe W.; Bernards, Rene; Mills, Gordon B.; Hennessy, Bryan T.

2008-05-06

Phosphatidylinositol-3-kinase (PI3K)/AKT pathway aberrations are common in cancer. By applying mass spectroscopy-based sequencing and reverse phase protein arrays to 547 human breast cancers and 41 cell lines, we determined the subtype specificity and signaling effects of PIK3CA, AKT and PTEN mutations, and the effects of PIK3CA mutations on responsiveness to PI3K inhibition in-vitro and on outcome after adjuvant tamoxifen. PIK3CA mutations were more common in hormone receptor positive (33.8%) and HER2-positive (24.6%) than in basal-like tumors (8.3%). AKT1 (1.4%) and PTEN (2.3%) mutations were restricted to hormone receptor-positive cancers with PTEN protein levels also being significantly lower in hormone receptor-positive cancers. Unlike AKT1 mutations, PIK3CA (39%) and PTEN (20%) mutations were more common in cell lines than tumors, suggesting a selection for these but not AKT1 mutations during adaptation to culture. PIK3CA mutations did not have a significant impact on outcome in 166 hormone receptor-positive breast cancer patients after adjuvant tamoxifen. PIK3CA mutations, in comparison with PTEN loss and AKT1 mutations, were associated with significantly less and indeed inconsistent activation of AKT and of downstream PI3K/AKT signaling in tumors and cell lines, and PTEN loss and PIK3CA mutation were frequently concordant, suggesting different contributions to pathophysiology. PTEN loss but not PIK3CA mutations rendered cells sensitive to growth inhibition by the PI3K inhibitor LY294002. Thus, PI3K pathway aberrations likely play a distinct role in the pathogenesis of different breast cancer subtypes. The specific aberration may have implications for the selection of PI3K-targeted therapies in hormone receptor-positive breast cancer.

Multi-Physics Demonstration Problem with the SHARP Reactor Simulation Toolkit

Energy Technology Data Exchange (ETDEWEB)

Merzari, E. [Argonne National Lab. (ANL), Argonne, IL (United States); Shemon, E. R. [Argonne National Lab. (ANL), Argonne, IL (United States); Yu, Y. Q. [Argonne National Lab. (ANL), Argonne, IL (United States); Thomas, J. W. [Argonne National Lab. (ANL), Argonne, IL (United States); Obabko, A. [Argonne National Lab. (ANL), Argonne, IL (United States); Jain, Rajeev [Argonne National Lab. (ANL), Argonne, IL (United States); Mahadevan, Vijay [Argonne National Lab. (ANL), Argonne, IL (United States); Tautges, Timothy [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Solberg, Jerome [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Ferencz, Robert Mark [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Whitesides, R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

2015-12-21

This report describes to employ SHARP to perform a first-of-a-kind analysis of the core radial expansion phenomenon in an SFR. This effort required significant advances in the framework Multi-Physics Demonstration Problem with the SHARP Reactor Simulation Toolkit used to drive the coupled simulations, manipulate the mesh in response to the deformation of the geometry, and generate the necessary modified mesh files. Furthermore, the model geometry is fairly complex, and consistent mesh generation for the three physics modules required significant effort. Fully-integrated simulations of a 7-assembly mini-core test problem have been performed, and the results are presented here. Physics models of a full-core model of the Advanced Burner Test Reactor have also been developed for each of the three physics modules. Standalone results of each of the three physics modules for the ABTR are presented here, which provides a demonstration of the feasibility of the fully-integrated simulation.

Modelling of thermalhydraulics and reactor physics in simulators

International Nuclear Information System (INIS)

Miettinen, J.

1994-01-01

The evolution of thermalhydraulic analysis methods for analysis and simulator purposes has brought closer the thermohydraulic models in both application areas. In large analysis codes like RELAP5, TRAC, CATHARE and ATHLET the accuracy for calculating complicated phenomena has been emphasized, but in spite of large development efforts many generic problems remain unsolved. For simulator purposes fast running codes have been developed and these include only limited assessment efforts. But these codes have more simulator friendly features than large codes, like portability and modular code structure. In this respect the simulator experiences with SMABRE code are discussed. Both large analysis codes and special simulator codes have their advances in simulator applications. The evolution of reactor physical calculation methods in simulator applications has started from simple point kinetic models. For analysis purposes accurate 1-D and 3-D codes have been developed being capable for fast and complicated transients. For simulator purposes capability for simulation of instruments has been emphasized, but the dynamic simulation capability has been less significant. The approaches for 3-dimensionality in simulators requires still quite much development, before the analysis accuracy is reached. (orig.) (8 refs., 2 figs., 2 tabs.)

Physical security at research reactors

International Nuclear Information System (INIS)

Clark, R.A.

1977-01-01

Of the 84 non-power research facilities licensed under 10 CFR Part 50, 73 are active (two test reactors, 68 research reactors and three critical facilities) and are required by 10 CFR Part 73.40 to provide physical protection against theft of SNM and against industrial sabotage. Each licensee has developed a security plan required by 10 CFR Part 50.34(c) to demonstrate the means of compliance with the applicable requirements of 10 CFR Part 73. In 1974, the Commission provided interim guidance for the organization and content of security plans for (a) test reactors, (b) medium power research and training reactors, and (c) low power research and training reactors. Eleven TRIGA reactors, with power levels greater than 250 kW and all other research and training reactors with power levels greater than 100 kW and less than or equal to 5,000 kW are designated as medium power research and training reactors. Thirteen TRIGA reactors with authorized power levels less than 250 kW are considered to be low power research and training reactors. Additional guidance for complying with the requirements of 73.50 and 73.60, if applicable, is provided in the Commission's Regulatory Guides. The Commission's Office of Inspection and Enforcement inspects each licensed facility to assure that an approved security plan is properly implemented with appropriate procedures and physical protection systems

Reactor physics computations

International Nuclear Information System (INIS)

Shapiro, A.

1977-01-01

Those reactor-core calculations which provide the effective multiplication factor (or eigenvalue) and the stationary (or fundamental mode) neutron-flux distribution at selected times during the lifetime of the core are considered. The multiplication factor is required to establish the nuclear composition and configuration which satisfy criticality and control requirements. The steady-state flux distribution must be known to calculate reaction rates and power distributions which are needed for the thermal, mechanical and shielding design of the reactor, as well as for evaluating refueling requirements. The calculational methods and techniques used for evaluating the nuclear design information vary with the type of reactor and with the preferences and prejudices of the reactor-physics group responsible for the calculation. Additionally, new methods and techniques are continually being developed and made operational. This results in a rather large conglomeration of methods and computer codes which are available for reactor analysis. The author provides the basic calculational framework and discusses the more prominent techniques which have evolved. (Auth.)

Physical models and primary design of reactor based slow positron source at CMRR

Science.gov (United States)

Wang, Guanbo; Li, Rundong; Qian, Dazhi; Yang, Xin

2018-07-01

Slow positron facilities are widely used in material science. A high intensity slow positron source is now at the design stage based on the China Mianyang Research Reactor (CMRR). This paper describes the physical models and our primary design. We use different computer programs or mathematical formula to simulate different physical process, and validate them by proper experiments. Considering the feasibility, we propose a primary design, containing a cadmium shield, a honeycomb arranged W tubes assembly, electrical lenses, and a solenoid. It is planned to be vertically inserted in the Si-doping channel. And the beam intensity is expected to be 5 ×109

IRT-type research reactor physical calculation methodology

International Nuclear Information System (INIS)

Carrera, W.; Castaneda, S.; Garcia, F.; Garcia, L.; Reyes, O.

1990-01-01

In the present paper an established physical calculation procedure for the research reactor of the Nuclear Research Center (CIN) is described. The results obtained by the method are compared with the ones reported during the physical start up of a reactor with similar characteristics to the CIN reactor. 11 refs

Final Physics Report for the Engineering Test Reactor

International Nuclear Information System (INIS)

Wolfe, I. B.

1956-01-01

This report is a summary of the physics design work performed on the Engineering Test Reactor. The ETR presents computational difficulties not found in other reactors because of the large number of experimental holes in the core. The physics of the ETR depends strongly upon the contents of the in-core experimental facilities. In order to properly evaluate the reactor' taking into account the experiments in the core, multi-region, two-dimensional calculations are required. These calculations require the use of a large computer such as the Remington Rand Univac and are complex and expensive enough to warrant a five-stage program: 1. In the early stages of design, only preliminary two-dimensional calculations were performed .in order to obtain a rough idea of the general behavior of the reactor and its critical mass with tentative experiments in place. 2. A large amount of work was carried out in which the reactor was approximated as one with a uniform homogeneous core. With this model, detailed studies were carried out to investigate the feasibility and to obtain general design data on such points as the design and properties of the gray and black control rods, the design of the beryllium reflector, gamma and neutron heating, the use of burnable poisons, etc. In performing these calculations, use was made of the IBM 650 PROD code obtained from KAPL. 3. With stages 1 and 2 carried out, two-dimensional calculations of the core at start-up conditions were performed on the Univac computer. 4. Detailed two-dimensional calculations of the properties of the ETR with a proposed first set of experiments in place were carried out. 5. A series of nuclear tests were performed at the reactivity measurements facility at the MTR site in order to confirm the validity of the analytical techniques in physics analysis. In performing the two-dimensional Univac calculations, the MUG code developed by KAPL and the Cuthill code developed at the David Taylor Model Basin were utilized. In

Three-dimensional multi-physics model of the European sodium fast reactor design applied to DBA analysis - 15293

International Nuclear Information System (INIS)

Lazaro, A.; Ordonez, J.; Martorell, S.; Przemyslaw, S.; Ammirabile, L.; Tsige-Tamirat, H.

2015-01-01

The sodium cooled fast reactor (SFR) is one of the reactor types selected by the Generation IV International Forum. SFR stand out due to its remarkable past operational experience in related projects and its potential to achieve the ambitious goals laid for the new generation of nuclear reactors. Regardless its operational experience, there is a need to apply computational tools able to simulate the system behaviour under conditions that may overtake the reactor safety limits from the early stages of the design process, including the three-dimensional phenomena that may arise in these transients. This paper presents the different steps followed towards the development of a multi-physics platform with capabilities to simulate complex phenomena using a coupled neutronic-thermal-hydraulic scheme. The development started with a one-dimensional thermal-hydraulic model of the European Sodium Fast Reactor (ESFR) design with point kinetic neutronic feedback benchmarked with its peers in the framework of the FP7-CP-ESFR project using the state-of-the-art thermal-hydraulic system code TRACE. The model was successively extended into a three-dimensional model coupled with the spatial kinetic neutronic code PARCS able to simulate three-dimensional multi-physic phenomena along with the comparison of the results for symmetric cases. The last part of the paper shows the application of the developed tool to the analysis of transients involving asymmetrical effects, such as the coast-down of a primary and secondary pump or the withdrawal of a peripheral control rod bank, demonstrating the unique capability of the code to simulate such transients and the capability of the design to withstand them under design basis

Operational reactor physics analysis codes (ORPAC)

International Nuclear Information System (INIS)

Kumar, Jainendra; Singh, K.P.; Singh, Kanchhi

2007-07-01

For efficient, smooth and safe operation of a nuclear research reactor, many reactor physics evaluations are regularly required. As part of reactor core management the important activities are maintaining core reactivity status, core power distribution, xenon estimations, safety evaluation of in-pile irradiation samples and experimental assemblies and assessment of nuclear safety in fuel handling/storage. In-pile irradiation of samples requires a prior estimation of the reactivity load due to the sample, the heating rate and the activity developed in it during irradiation. For the safety of personnel handling irradiated samples the dose rate at the surface of shielded flask housing the irradiated sample should be less than 200 mR/Hr.Therefore, a proper shielding and radioactive cooling of the irradiated sample are required to meet the said requirement. Knowledge of xenon load variation with time (Startup-curve) helps in estimating Xenon override time. Monitoring of power in individual fuel channels during reactor operation is essential to know any abnormal power distribution to avoid unsafe situations. Complexities in the estimation of above mentioned reactor parameters and their frequent requirement compel one to use computer codes to avoid possible human errors. For efficient and quick evaluation of parameters related to reactor operations such as xenon load, critical moderator height and nuclear heating and reactivity load of isotope samples/experimental assembly, a computer code ORPAC (Operational Reactor Physics Analysis Codes) has been developed. This code is being used for regular assessment of reactor physics parameters in Dhruva and Cirus. The code ORPAC written in Visual Basic 6.0 environment incorporates several important operational reactor physics aspects on a single platform with graphical user interfaces (GUI) to make it more user-friendly and presentable. (author)

Summary of the progress of reactor physics in Japan reviewing the activities related to NEA Committee on Reactor Physics

International Nuclear Information System (INIS)

Hirota, Jitsuya

1984-09-01

The progress of fast and thermal reactor physics, fusion neutronics and shielding researches in these twenty years can be clearly recognized in the reviews of reactor physics activities in Japan which had been perpared by the Special Committee on Reactor Physics: the joint committee under Atomic Energy Society of Japan and JAERI. Many topics of those discussed at the NEACRP meetings concerned fast reactor physics. Information exchange on the topics such as adjustment of group cross sections by integral data, central worth discrepancy, sodium void effect and heterogeneous core stimulated the researches in Japan. And achievements in Japan including those in the JAERI Fast Critical Facility FCA were reported and contributed largely to the international co-operation. In addition, the contribution from Japan was also made concerning a study of fusion blanket. Among various specialists' meetings recommended by NEACRP, those on nuclear data and benchmarks for reactor shielding were often held since 1973 and helpful to the progress of shielding researches in Japan. The Third Specialists' Meeting on Reactor Noise (SMORN-III) was held in Tokyo in 1981, indicating the recent progress in safety-related applications of reactor noise analysis. The NEACRP benchmark tests were quite useful to the progress of reactor physics in Japan, which included the benchmark calculations of BWR lattice cell, key parameters and burn-up characteristics of a large LMFBR, FBR and PWR shielding, and so on. It may be noted that the benchmark test on reactor noise analysis methods was successfully conducted by Japan in connection with SMORN-III. In addition, the co-operation was positively made to the compilation of light water lattice data, and the preparation of reviews on actinide production and burn-up, and blanket physics. (J.P.N.)

Specification of the Advanced Burner Test Reactor Multi-Physics Coupling Demonstration Problem

Energy Technology Data Exchange (ETDEWEB)

Shemon, E. R. [Argonne National Lab. (ANL), Argonne, IL (United States); Grudzinski, J. J. [Argonne National Lab. (ANL), Argonne, IL (United States); Lee, C. H. [Argonne National Lab. (ANL), Argonne, IL (United States); Thomas, J. W. [Argonne National Lab. (ANL), Argonne, IL (United States); Yu, Y. Q. [Argonne National Lab. (ANL), Argonne, IL (United States)

2015-12-21

This document specifies the multi-physics nuclear reactor demonstration problem using the SHARP software package developed by NEAMS. The SHARP toolset simulates the key coupled physics phenomena inside a nuclear reactor. The PROTEUS neutronics code models the neutron transport within the system, the Nek5000 computational fluid dynamics code models the fluid flow and heat transfer, and the DIABLO structural mechanics code models structural and mechanical deformation. The three codes are coupled to the MOAB mesh framework which allows feedback from neutronics, fluid mechanics, and mechanical deformation in a compatible format.

Current status of the reactor physics code WIMS and recent developments

International Nuclear Information System (INIS)

Lindley, B.A.; Hosking, J.G.; Smith, P.J.; Powney, D.J.; Tollit, B.S.; Newton, T.D.; Perry, R.; Ware, T.C.; Smith, P.N.

2017-01-01

Highlights: • The current status of the WIMS reactor physics code is presented. • Applications range from 2D lattice calculations up to 3D whole core geometries. • Gamma transport and thermal-hydraulic feedback models added. • Calculations methodologies described for several Gen II, III and IV reactor types. - Abstract: The WIMS modular reactor physics code has been under continuous development for over fifty years. This paper discusses the current status of WIMS and recent developments, in particular developments to the resonance shielding methodology and 3D transport solvers. Traditionally, WIMS is used to perform 2D lattice calculations, typically to generate homogenized reactor physics parameters for a whole core code such as PANTHER. However, with increasing computational resources there has been a growing trend for performing transport calculations on larger problems, up to and including 3D full core models. To this end, a number of the WIMS modules have been parallelised to allow efficient performance for whole core calculations, and WIMS includes a 3D method of characteristics solver with reflective and once-through tracking methods, which can be used to analyse problems of varying size and complexity. A time-dependent flux solver has been incorporated and thermal-hydraulic modelling capability is also being added to allow steady-state and transient coupled calculations to be performed. WIMS has been validated against a range of experimental data and other codes, in particular for water and graphite moderated thermal reactors. Future developments will include improved parallelization, enhancing the thermal-hydraulic feedback models and validating the WIMS/PANTHER code system for BWRs and fast reactors.

Phosphatidyl inositol-3 kinase (PIK3CA) E545K mutation confers cisplatin resistance and a migratory phenotype in cervical cancer cells

Science.gov (United States)

Arjumand, Wani; Merry, Cole D.; Wang, Chen; Saba, Elias; McIntyre, John B.; Fang, Shujuan; Kornaga, Elizabeth; Ghatage, Prafull; Doll, Corinne M.; Lees, Susan P.

2016-01-01

The phosphatidylinositol-3 kinase (PI3K)/Akt/mTOR signaling pathway is activated in many human cancers. Previously, we reported that patients with early stage cervical cancer whose tumours harbour PIK3CA exon 9 or 20 mutations have worse overall survival in response to treatment with radiation and cisplatin than patients with wild-type PIK3CA. The purpose of this study was to determine whether PIK3CA-E545K mutation renders cervical cancer cells more resistant to cisplatin and/or radiation, and whether PI3K inhibition reverses the phenotype. We found that CaSki cells that are heterozygous for the PIK3CA-E545K mutation are more resistant to cisplatin or cisplatin plus radiation than either HeLa or SiHa cells that express only wild-type PIK3CA. Similarly, HeLa cells engineered to stably express PIK3CA-E545K were more resistant to cisplatin or cisplatin plus radiation than cells expressing only wild-type PIK3CA or with PIK3CA depleted. Cells expressing the PIK3CA-E545K mutation also had constitutive PI3K pathway activation and increased cellular migration and each of these phenotypes was reversed by treatment with the PI3K inhibitor GDC-0941/Pictilisib. Our results suggests that cervical cancer patients whose tumours are positive for the PIK3CA-E545K mutation may benefit from PI3K inhibitor therapy in concert with standard cisplatin and radiation therapy. PMID:27489350

Activity report of Reactor Physics Section - 1985

International Nuclear Information System (INIS)

John, T.M.

1986-01-01

This Activity Report contains brief summaries of different studies made in Reactor Physics Section during the year 1985. These are presented under the headings Nuclear Data Processing and Validation, Reactor Design and Analysis, Safety and Noise Analysis, Radiation Transport and Shielding, Reactor Physics Experiments and Statistical Physics. The work on nuclear data during this period comprises primarily of validation of data of 232 Th and 233 U as a part of participation in the Co-ordinated Research Programme (CRP) under IAEA research contract. The most significant event during 1985 at this centre has been the first criticality of FBTR (Fast Breeder Test Reactor), which was achieved on the 18th of October. Reactor Physics Section has played a key role in this event by carrying out the first approach to criticality with fuel loading in a safe manner and conducting some low power reactor physics experiments which are discussed. The studies made in the field reactor safety and shielding are also connected mainly with the FBTR problems in addition to some work on the PFBR (Prototype Fast Breeder Reactor) detailed design of which has been just started. Studies pertaining to the other two Co-ordinated Research Programmes (CRP) under IAEA contract, namely (1) on the comparative assessment of processing techniques for the analysis of sodium boiling noise detection and, (2) on the contribution of advanced reactors to energy supply have been continued during this year. At the end of this report, a list of publications made by the members of the section and also the sectional seminars held during this period is included. (author)

Tumor PIK3CA genotype and prognosis in early-stage breast cancer

DEFF Research Database (Denmark)

Zardavas, Dimitrios; Te Marvelde, Luc; Milne, Roger L.

2018-01-01

% in the ER-negative/HER2-negative, HER2-positive, and ER-positive/HER2-negative subtypes, respectively. In univariable analysis, PIK3CA mutations were associated with better IDFS (HR, 0.77; 95% CI, 0.71 to 0.84; P, .001), with evidence for a stronger effect in the first years of follow-up (0 to 5 years: HR...... points. Conclusion In this large pooled analysis, PIK3CA mutations were significantly associated with a better IDFS, DDFS, and OS, but had a lesser prognostic effect after adjustment for other prognostic factors....

Mutant PIK3CA Induces EMT in a Cell Type Specific Manner.

Directory of Open Access Journals (Sweden)

Divya Bhagirath

Full Text Available Breast cancer is characterized into different molecular subtypes, and each subtype is characterized by differential gene expression that are associated with distinct survival outcomes in patients. PIK3CA mutations are commonly associated with most breast cancer subtypes. More recently PIK3CA mutations have been shown to induce tumor heterogeneity and are associated with activation of EGFR-signaling and reduced relapse free survival in basal subtype of breast cancer. Thus, understanding what determines PIK3CA induced heterogeneity and oncogenesis, is an important area of investigation. In this study, we assessed the effect of mutant PIK3CA together with mutant Ras plus mutant p53 on oncogenic behavior of two distinct stem/progenitor breast cell lines, designated as K5+/K19- and K5+/K19+. Constructs were ectopically overexpressed in K5+/K19- and K5+/K19+ stem/progenitor cells, followed by various in-vitro and in-vivo analyses. Oncogene combination m-Ras/m-p53/m-PIK3CA efficiently transformed both K5+/K19- and K5+/K19+ cell lines in-vitro, as assessed by anchorage-independent soft agar colony formation assay. Significantly, while this oncogene combination induced a complete epithelial-to-mesenchymal transition (EMT in K5+/K19- cell line, mostly epithelial phenotype with minor EMT component was seen in K5+/K19+ cell line. However, both K5+/K19- and K5+/K19+ transformed cells exhibited increased invasion and migration abilities. Analyses of CD44 and CD24 expression showed both cell lines had tumor-initiating CD44+/CD24low cell population, however transformed K5+/K19- cells had more proportion of these cells. Significantly, both cell types exhibited in-vivo tumorigenesis, and maintained their EMT and epithelial nature in-vivo in mice tumors. Notably, while both cell types exhibited increase in tumor-initiating cell population, differential EMT phenotype was observed in these cell lines. These results suggest that EMT is a cell type dependent

Effective lifetime measurements in the $B_{s}^{0} \\rightarrow K^{+}K^{-}$, $B^{0} \\rightarrow K^{+}\\pi^{-}$ and $B_{s}^{0} \\rightarrow \\pi^{+}K^{-}$ decays

CERN Document Server

INSPIRE-00258707; Adeva, B.; Adinolfi, M.; Affolder, A.; Ajaltouni, Z.; Albrecht, J.; Alessio, F.; Alexander, M.; Ali, S.; Alkhazov, G.; Alvarez Cartelle, P.; Alves Jr, A.A.; Amato, S.; Amerio, S.; Amhis, Y.; An, L.; Anderlini, L.; Anderson, J.; Andreassen, R.; Andreotti, M.; Andrews, J.E.; Appleby, R.B.; Aquines Gutierrez, O.; Archilli, F.; Artamonov, A.; Artuso, M.; Aslanides, E.; Auriemma, G.; Baalouch, M.; Bachmann, S.; Back, J.J.; Badalov, A.; Balagura, V.; Baldini, W.; Barlow, R.J.; Barschel, C.; Barsuk, S.; Barter, W.; Batozskaya, V.; Bauer, Th.; Bay, A.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Belogurov, S.; Belous, K.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S.; Benton, J.; Berezhnoy, A.; Bernet, R.; Bettler, M.O.; van Beuzekom, M.; Bien, A.; Bifani, S.; Bird, T.; Bizzeti, A.; Bjornstad, P.M.; Blake, T.; Blanc, F.; Blouw, J.; Blusk, S.; Bocci, V.; Bondar, A.; Bondar, N.; Bonivento, W.; Borghi, S.; Borgia, A.; Borsato, M.; Bowcock, T.J.V.; Bowen, E.; Bozzi, C.; Brambach, T.; van den Brand, J.; Bressieux, J.; Brett, D.; Britsch, M.; Britton, T.; Brook, N.H.; Brown, H.; Bursche, A.; Busetto, G.; Buytaert, J.; Cadeddu, S.; Calabrese, R.; Calvi, M.; Calvo Gomez, M.; Camboni, A.; Campana, P.; Campora Perez, D.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carranza-Mejia, H.; Carson, L.; Carvalho Akiba, K.; Casse, G.; Cassina, L.; Garcia, L.Castillo; Cattaneo, M.; Cauet, Ch.; Cenci, R.; Charles, M.; Charpentier, Ph.; Cheung, S.F.; Chiapolini, N.; Chrzaszcz, M.; Ciba, K.; Cid Vidal, X.; Ciezarek, G.; Clarke, P.E.L.; Clemencic, M.; Cliff, H.V.; Closier, J.; Coco, V.; Cogan, J.; Cogneras, E.; Collins, P.; Comerma-Montells, A.; Contu, A.; Cook, A.; Coombes, M.; Coquereau, S.; Corti, G.; Corvo, M.; Counts, I.; Couturier, B.; Cowan, G.A.; Craik, D.C.; Cruz Torres, M.; Cunliffe, S.; Currie, R.; D'Ambrosio, C.; Dalseno, J.; David, P.; David, P.N.Y.; Davis, A.; De Bruyn, K.; De Capua, S.; De Cian, M.; de Miranda, J.M.; De Paula, L.; De Silva, W.; De Simone, P.; Decamp, D.; Deckenhoff, M.; Del Buono, L.; Deleage, N.; Derkach, D.; Deschamps, O.; Dettori, F.; Di Canto, A.; Dijkstra, H.; Donleavy, S.; Dordei, F.; Dorigo, M.; Dosil Suarez, A.; Dossett, D.; Dovbnya, A.; Dupertuis, F.; Durante, P.; Dzhelyadin, R.; Dziurda, A.; Dzyuba, A.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; El Rifai, I.; Elsasser, Ch.; Esen, S.; Evans, T.; Falabella, A.; Farber, C.; Farinelli, C.; Farley, N.; Farry, S.; Ferguson, D.; Fernandez Albor, V.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fiore, M.; Fiorini, M.; Firlej, M.; Fitzpatrick, C.; Fiutowski, T.; Fontana, M.; Fontanelli, F.; Forty, R.; Francisco, O.; Frank, M.; Frei, C.; Frosini, M.; Fu, J.; Furfaro, E.; Gallas Torreira, A.; Galli, D.; Gallorini, S.; Gambetta, S.; Gandelman, M.; Gandini, P.; Gao, Y.; Garofoli, J.; Garra Tico, J.; Garrido, L.; Gaspar, C.; Gauld, R.; Gavardi, L.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Gianelle, A.; Giani', S.; Gibson, V.; Giubega, L.; Gligorov, V.V.; Gobel, C.; Golubkov, D.; Golutvin, A.; Gomes, A.; Gordon, H.; Gotti, C.; Grabalosa Gandara, M.; Graciani Diaz, R.; Granado Cardoso, L.A.; Grauges, E.; Graziani, G.; Grecu, A.; Greening, E.; Gregson, S.; Griffith, P.; Grillo, L.; Grunberg, O.; Gui, B.; Gushchin, E.; Guz, Yu.; Gys, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Haines, S.C.; Hall, S.; Hamilton, B.; Hampson, T.; Han, X.; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S.T.; Harrison, J.; Hartmann, T.; He, J.; Head, T.; Heijne, V.; Hennessy, K.; Henrard, P.; Henry, L.; Hernando Morata, J.A.; van Herwijnen, E.; Hess, M.; Hicheur, A.; Hill, D.; Hoballah, M.; Hombach, C.; Hulsbergen, W.; Hunt, P.; Hussain, N.; Hutchcroft, D.; Hynds, D.; Idzik, M.; Ilten, P.; Jacobsson, R.; Jaeger, A.; Jalocha, J.; Jans, E.; Jaton, P.; Jawahery, A.; Jezabek, M.; Jing, F.; John, M.; Johnson, D.; Jones, C.R.; Joram, C.; Jost, B.; Jurik, N.; Kaballo, M.; Kandybei, S.; Kanso, W.; Karacson, M.; Karbach, T.M.; Kelsey, M.; Kenyon, I.R.; Ketel, T.; Khanji, B.; Khurewathanakul, C.; Klaver, S.; Kochebina, O.; Kolpin, M.; Komarov, I.; Koopman, R.F.; Koppenburg, P.; Korolev, M.; Kozlinskiy, A.; Kravchuk, L.; Kreplin, K.; Kreps, M.; Krocker, G.; Krokovny, P.; Kruse, F.; Kucharczyk, M.; Kudryavtsev, V.; Kurek, K.; Kvaratskheliya, T.; La Thi, V.N.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lambert, D.; Lambert, R.W.; Lanciotti, E.; Lanfranchi, G.; Langenbruch, C.; Langhans, B.; Latham, T.; Lazzeroni, C.; Le Gac, R.; van Leerdam, J.; Lees, J.P.; Lefevre, R.; Leflat, A.; Lefrancois, J.; Leo, S.; Leroy, O.; Lesiak, T.; Leverington, B.; Li, Y.; Liles, M.; Lindner, R.; Linn, C.; Lionetto, F.; Liu, B.; Liu, G.; Lohn, S.; Longstaff, I.; Lopes, J.H.; Lopez-March, N.; Lowdon, P.; Lu, H.; Lucchesi, D.; Luo, H.; Lupato, A.; Luppi, E.; Lupton, O.; Machefert, F.; Machikhiliyan, I.V.; Maciuc, F.; Maev, O.; Malde, S.; Manca, G.; Mancinelli, G.; Manzali, M.; Maratas, J.; Marchand, J.F.; Marconi, U.; Benito, C.Marin; Marino, P.; Marki, R.; Marks, J.; Martellotti, G.; Martens, A.; Martin Sanchez, A.; Martinelli, M.; Martinez Santos, D.; Martinez Vidal, F.; Martins Tostes, D.; Massafferri, A.; Matev, R.; Mathe, Z.; Matteuzzi, C.; Mazurov, A.; McCann, M.; McCarthy, J.; McNab, A.; McNulty, R.; McSkelly, B.; Meadows, B.; Meier, F.; Meissner, M.; Merk, M.; Milanes, D.A.; Minard, M.N.; Moggi, N.; Molina Rodriguez, J.; Monteil, S.; Moran, D.; Morandin, M.; Morawski, P.; Morda, A.; Morello, M.J.; Moron, J.; Mountain, R.; Muheim, F.; Muller, K.; Muresan, R.; Mussini, M.; Muster, B.; Naik, P.; Nakada, T.; Nandakumar, R.; Nasteva, I.; Needham, M.; Neri, N.; Neubert, S.; Neufeld, N.; Neuner, M.; Nguyen, A.D.; Nguyen, T.D.; Nguyen-Mau, C.; Nicol, M.; Niess, V.; Niet, R.; Nikitin, N.; Nikodem, T.; Novoselov, A.; Oblakowska-Mucha, A.; Obraztsov, V.; Oggero, S.; Ogilvy, S.; Okhrimenko, O.; Oldeman, R.; Onderwater, G.; Orlandea, M.; Otalora Goicochea, J.M.; Owen, P.; Oyanguren, A.; Pal, B.K.; Palano, A.; Palombo, F.; Palutan, M.; Panman, J.; Papanestis, A.; Pappagallo, M.; Parkes, C.; Parkinson, C.J.; Passaleva, G.; Patel, G.D.; Patel, M.; Patrignani, C.; Pazos Alvarez, A.; Pearce, A.; Pellegrino, A.; Pepe Altarelli, M.; Perazzini, S.; Perez Trigo, E.; Perret, P.; Perrin-Terrin, M.; Pescatore, L.; Pesen, E.; Petridis, K.; Petrolini, A.; Picatoste Olloqui, E.; Pietrzyk, B.; Pilar, T.; Pinci, D.; Pistone, A.; Playfer, S.; Plo Casasus, M.; Polci, F.; Poluektov, A.; Polycarpo, E.; Popov, A.; Popov, D.; Popovici, B.; Potterat, C.; Powell, A.; Prisciandaro, J.; Pritchard, A.; Prouve, C.; Pugatch, V.; Puig Navarro, A.; Punzi, G.; Qian, W.; Rachwal, B.; Rademacker, J.H.; Rakotomiaramanana, B.; Rama, M.; Rangel, M.S.; Raniuk, I.; Rauschmayr, N.; Raven, G.; Reichert, S.; Reid, M.M.; dos Reis, A.C.; Ricciardi, S.; Richards, A.; Rihl, M.; Rinnert, K.; Rives Molina, V.; Roa Romero, D.A.; Robbe, P.; Rodrigues, A.B.; Rodrigues, E.; Rodriguez Perez, P.; Roiser, S.; Romanovsky, V.; Vidal, A.Romero; Rotondo, M.; Rouvinet, J.; Ruf, T.; Ruffini, F.; Ruiz, H.; Valls, P.Ruiz; Sabatino, G.; Saborido Silva, J.J.; Sagidova, N.; Sail, P.; Saitta, B.; Salustino Guimaraes, V.; Sanchez Mayordomo, C.; Sanmartin Sedes, B.; Santacesaria, R.; Santamarina Rios, C.; Santovetti, E.; Sapunov, M.; Sarti, A.; Satriano, C.; Satta, A.; Savrie, M.; Savrina, D.; Schiller, M.; Schindler, H.; Schlupp, M.; Schmelling, M.; Schmidt, B.; Schneider, O.; Schopper, A.; Schune, M.H.; Schwemmer, R.; Sciascia, B.; Sciubba, A.; Seco, M.; Semennikov, A.; Senderowska, K.; Sepp, I.; Serra, N.; Serrano, J.; Sestini, L.; Seyfert, P.; Shapkin, M.; Shapoval, I.; Shcheglov, Y.; Shears, T.; Shekhtman, L.; Shevchenko, V.; Shires, A.; Coutinho, R.Silva; Simi, G.; Sirendi, M.; Skidmore, N.; Skwarnicki, T.; Smith, N.A.; Smith, E.; Smith, E.; Smith, J.; Smith, M.; Snoek, H.; Sokoloff, M.D.; Soler, F.J.P.; Soomro, F.; Souza, D.; Souza De Paula, B.; Spaan, B.; Sparkes, A.; Spinella, F.; Spradlin, P.; Stagni, F.; Stahl, S.; Steinkamp, O.; Stenyakin, O.; Stevenson, S.; Stoica, S.; Stone, S.; Storaci, B.; Stracka, S.; Straticiuc, M.; Straumann, U.; Stroili, R.; Subbiah, V.K.; Sun, L.; Sutcliffe, W.; Swientek, K.; Swientek, S.; Syropoulos, V.; Szczekowski, M.; Szczypka, P.; Szilard, D.; Szumlak, T.; T'Jampens, S.; Teklishyn, M.; Tellarini, G.; Teubert, F.; Thomas, C.; Thomas, E.; van Tilburg, J.; Tisserand, V.; Tobin, M.; Tolk, S.; Tomassetti, L.; Tonelli, D.; Topp-Joergensen, S.; Torr, N.; Tournefier, E.; Tourneur, S.; Tran, M.T.; Tresch, M.; Tsaregorodtsev, A.; Tsopelas, P.; Tuning, N.; Garcia, M.Ubeda; Ukleja, A.; Ustyuzhanin, A.; Uwer, U.; Vagnoni, V.; Valenti, G.; Vallier, A.; Vazquez Gomez, R.; Vazquez Regueiro, P.; Vazquez Sierra, C.; Vecchi, S.; Velthuis, J.J.; Veltri, M.; Veneziano, G.; Vesterinen, M.; Viaud, B.; Vieira, D.; Vieites Diaz, M.; Vilasis-Cardona, X.; Vollhardt, A.; Volyanskyy, D.; Voong, D.; Vorobyev, A.; Vorobyev, V.; Voss, C.; Voss, H.; de Vries, J.A.; Waldi, R.; Wallace, C.; Wallace, R.; Walsh, J.; Wandernoth, S.; Wang, J.; Ward, D.R.; Watson, N.K.; Websdale, D.; Whitehead, M.; Wicht, J.; Wiedner, D.; Wilkinson, G.; Williams, M.P.; Williams, M.; Wilson, F.F.; Wimberley, J.; Wishahi, J.; Wislicki, W.; Witek, M.; Wormser, G.; Wotton, S.A.; Wright, S.; Wu, S.; Wyllie, K.; Xie, Y.; Xing, Z.; Xu, Z.; Yang, Z.; Yuan, X.; Yushchenko, O.; Zangoli, M.; Zavertyaev, M.; Zhang, F.; Zhang, L.; Zhang, W.C.; Zhang, Y.; Zhelezov, A.; Zhokhov, A.; Zhong, L.; Zvyagin, A.

2014-01-01

Measurements of the effective lifetimes in the $B_{s}^{0} \\rightarrow K^{+}K^{-}$, $B^{0} \\rightarrow K^{+}\\pi^{-}$ and $B_{s}^{0} \\rightarrow \\pi^{+}K^{-}$ decays are presented using $1.0~\\mathrm{fb^{-1}}$ of $pp$ collision data collected at a centre-of-mass energy of 7 TeV by the LHCb experiment. The analysis uses a data-driven approach to correct for the decay time acceptance. The measured effective lifetimes are $\\tau_{B_{s}^{0} \\rightarrow K^{+}K^{-}}$ = $1.407~\\pm~0.016~\\pm~0.007~\\mathrm{ps}$, $\\tau_{B^{0} \\rightarrow K^{+}\\pi^{-}}$ = $1.524~\\pm~0.011~\\pm~0.004~\\mathrm{ps}$, $\\tau_{B_{s}^{0} \\rightarrow \\pi^{+}K^{-}}$ = $1.60~\\pm~0.06~\\pm~0.01~\\mathrm{ps}$. This is the most precise determination to date of the effective lifetime in the $B_{s}^{0} \\rightarrow K^{+}K^{-}$ decay and provides constraints on contributions from physics beyond the Standard Model to the $B_{s}^{0}$ mixing phase and the width difference $\\Delta\\Gamma_{s}$.

Nuclear reactors: physics and materials

Energy Technology Data Exchange (ETDEWEB)

Yadigaroglu, G

2005-07-01

In the form of a tutorial addressed to non-specialists, the article provides an introduction to nuclear reactor technology and more specifically to Light Water Reactors (LWR); it also shows where materials and chemistry problems are encountered in reactor technology. The basics of reactor physics are reviewed, as well as the various strategies in reactor design and the corresponding choices of materials (fuel, coolant, structural materials, etc.). A brief description of the various types of commercial power reactors follows. The design of LWRs is discussed in greater detail; the properties of light water as coolant and moderator are put in perspective. The physicochemical and metallurgical properties of the materials impose thermal limits that determine the performance and the maximum power a reactor can deliver. (author)

Current trends in and prospects for development of Russian research reactors

International Nuclear Information System (INIS)

Arkhangelsky, N.V.; Cherepnin, Yu.S.; Gabaraev, B.A.; Khmelshchikov, V.V.; Tretiyakov, I.T.

2004-01-01

Over more than fifty years, many research reactors were built to Russian designs both at home and abroad, which is a considerable contribution to the world reactor engineering. Russian research reactors proved to be successful to an extent that it was found possible to raise capacity and to extend the range of their application. Though having a fairly long operating record, the majority of Russian research reactors are far from the end of their service life and are still in active use. In 2000, the 'Strategy of nuclear power development in Russia in the first half of the 21 st century' was elaborated and approved. The requirements of national nuclear power and the possible ways of its development identified in this document called for assessing the existing research capabilities. The findings of such assessment are presented in this report. The main conclusion lies in the following. On the one hand, the number and experimental capabilities of domestic research reactors are sufficient for coping with the objectives of research in, and on the other hand, retrofitting and upgrading appear to be the most expedient way of managing the operation of research reactors in the near term. Activities are under way to upgrade and extend the service life of multipurpose reactors, such as MIR-M1, SM-3, IRV-1M, BOR-60, IVV-2M, and others. The Federal Agency of the Russian Federation for Atomic Energy (Rosatom) supports the development of reactors intended for fundamental research with the use of neutron beams. To this end, Rosatom renders financial and professional support with a view to complete the PIK reactor construction at PIYaF and the IBR-2 reactor upgrades at JINR. In a longer term, the development of research reactors in Russia is expected to have the following pattern: - a small number of high-flux testing reactors with up-to-date experimental facilities located on the sites of the existing research centers; - PIK reactor, catering to domestic and foreign needs for beam

DOE fundamentals handbook: Nuclear physics and reactor theory

International Nuclear Information System (INIS)

1993-01-01

The Nuclear Physics and Reactor Theory Handbook was developed to assist nuclear facility operating contractors in providing operators, maintenance personnel, and the technical staff with the necessary fundamentals training to ensure a basic understanding of nuclear physics and reactor theory. The handbook includes information on atomic and nuclear physics; neutron characteristics; reactor theory and nuclear parameters; and the theory of reactor operation. This information will provide personnel with a foundation for understanding the scientific principles that are associated with various DOE nuclear facility operations and maintenance

Highly sensitive detection of the PIK3CAH1047R mutation in colorectal cancer using a novel PCR-RFLP method

International Nuclear Information System (INIS)

Li, Wan-Ming; Hu, Ting-Ting; Zhou, Lin-Lin; Feng, Yi-Ming; Wang, Yun-Yi; Fang, Jin

2016-01-01

The PIK3CA H1047R mutation is considered to be a potential predictive biomarker for EGFR-targeted therapies. In this study, we developed a novel PCR-PFLP approach to detect the PIK3CA H1047R mutation in high effectiveness. A 126-bp fragment of PIK3CA exon-20 was amplified by PCR, digested with FspI restriction endonuclease and separated by 3 % agarose gel electrophoresis for the PCR-RFLP analysis. The mutant sequence of the PIK3CA H1047R was spiked into the corresponding wild-type sequence in decreasing ratios for sensitivity analysis. Eight-six cases of formalin-fixed paraffin-embedded colorectal cancer (CRC) specimens were subjected to PCR-RFLP to evaluate the applicability of the method. The PCR-RFLP method had a capability to detect as litter as 0.4 % of mutation, and revealed 16.3 % of the PIK3CA H1047R mutation in 86 CRC tissues, which was significantly higher than that discovered by DNA sequencing (9.3 %). A positive association between the PIK3CA H1047R mutation and the patients’ age was first found, except for the negative relationship with the degree of tumor differentiation. In addition, the highly sensitive detection of a combinatorial mutation of PIK3CA, KRAS and BRAF was achieved using individual PCR-RFLP methods. We developed a sensitive, simple and rapid approach to detect the low-abundance PIK3CA H1047R mutation in real CRC specimens, providing an effective tool for guiding cancer targeted therapy

Assessing PIK3CA and PTEN in Early-Phase Trials with PI3K/AKT/mTOR Inhibitors

Directory of Open Access Journals (Sweden)

Filip Janku

2014-01-01

Full Text Available Despite a wealth of preclinical studies, it is unclear whether PIK3CA or phosphatase and tensin homolog (PTEN gene aberrations are actionable in the clinical setting. Of 1,656 patients with advanced, refractory cancers tested for PIK3CA or PTEN abnormalities, PIK3CA mutations were found in 9% (146/1,589, and PTEN loss and/or mutation was found in 13% (149/1,157. In multicovariable analysis, treatment with a phosphatidylinositol 3-kinase (PI3K/AKT/mammalian target of rapamycin (mTOR inhibitor was the only independent factor predicting response to therapy in individuals harboring a PIK3CA or PTEN aberration. The rate of stable disease ≥6 months/partial response reached 45% in a subgroup of individuals with H1047R PIK3CA mutations. Aberrations in the PI3K/AKT/mTOR pathway are common and potentially actionable in patients with diverse advanced cancers. This work provides further important clinical validation for continued and accelerated use of biomarker-driven trials incorporating rational drug combinations.

Activity report of Reactor Physics Division - 1988

International Nuclear Information System (INIS)

Keshavamurthy, R.S.

1989-01-01

This report highlights the progress of activities carried out during the year 1988 in Reactor Physics Division in the form of brief summaries. The topics are organised under the following subject categories:(1) nuclear data evaluation , processing and validation, (2) core physics and analysis, (3) reactor kinetics and safety analysis, (4) noise analysis and (5) radiation transport and shielding. List of publications by the members of the Division and the Reactor Physics Seminars held during the year 1988, is included at the end of report. (author). refs., figs., tabs

Highly frequent promoter methylation and PIK3CA amplification in non-small cell lung cancer (NSCLC)

International Nuclear Information System (INIS)

Ji, Meiju; Guan, Haixia; Gao, Cuixia; Shi, Bingyin; Hou, Peng

2011-01-01

Lung cancer is the leading cause of cancer-related death worldwide. Genetic and epigenetic alterations have been identified frequently in lung cancer, such as promoter methylation, gene mutations and genomic amplification. However, the interaction between genetic and epigenetic events and their significance in lung tumorigenesis remains poorly understood. We determined the promoter methylation of 6 genes and PIK3CA amplification using quantitative methylation-specific PCR (Q-MSP) and real-time quantitative PCR, respectively, and explore the association of promoter methylation with PIK3CA amplification in a large cohort of clinically well-characterized non-small cell lung cancer (NSCLC). Highly frequent promoter methylation was observed in NSCLC. With 100% diagnostic specificity, excellent sensitivity, ranging from 45.8 to 84.1%, was found for each of the 6 genes. The promoter methylation was associated with histologic type. Methylation of CALCA, CDH1, DAPK1, and EVX2 was more common in squamous cell carcinomas (SCC) compared to adenocarcinomas (ADC). Conversely, there was a trend toward a higher frequency of RASSF1A methylation in ADC than SCC. In addition, PIK3CA amplification was frequently found in NSCLC, and was associated with certain clinicopathologic features, such as smoking history, histologic type and pleural indentation. Importantly, aberrant promoter methylation of certain genes was significantly associated with PIK3CA amplification. Our data showed highly frequent promoter methylation and PIK3CA amplification in Chinese NSCLC population, and first demonstrated the associations of gene methylation with PIK3CA amplification, suggesting that these epigenetic events may be a consequence of overactivation of PI3K/Akt pathway

Reactor physics methods development at Westinghouse

International Nuclear Information System (INIS)

Mueller, E.; Mayhue, L.; Zhang, B.

2007-01-01

The current state of reactor physics methods development at Westinghouse is discussed. The focus is on the methods that have been or are under development within the NEXUS project which was launched a few years ago. The aim of this project is to merge and modernize the methods employed in the PWR and BWR steady-state reactor physics codes of Westinghouse. (author)

Fast reactor physics - an overview

International Nuclear Information System (INIS)

Lee, S.M.

2004-01-01

An introduction to the basic features of fast neutron reactors is made, highlighting the differences from the more conventional thermal neutron reactors. A discussion of important feedback reactivity mechanisms is given. Then an overview is presented of the methods of fast reactor physics, which play an important role in the successful design and operation of fast reactors. The methods are based on three main elements, namely (i) nuclear data bases, (ii) numerical methods and computer codes, and (iii) critical experiments. These elements are reviewed and the present status and future trends are summarized. (author)

Activity report of Reactor Physics Division - 1993

International Nuclear Information System (INIS)

Indira, R.

1994-01-01

The research and development (R and D) activities of the Reactor Physics Division of Indira Gandhi Centre for Atomic Research (IGCAR), Kalpakkam during 1993 are reported. The activities are arranged under the headings: Nuclear Data Processing and validation, Core Physics and Operation Studies, Reactor Kinetics and Safety analysis, Reactor Noise Analysis and Radiation Transport and Shielding Studies. List of publication is given at the end. (author). refs., figs., tabs

Activity report of Reactor Physics Division-1995

International Nuclear Information System (INIS)

Gopalakrishnan, V.

1996-01-01

The research and development (R and D) activities of the Reactor Physics Division of Indira Gandhi Centre for Atomic Research (IGCAR), Kalpakkam during 1995 are reported. The activity are arranged under the headings: Nuclear Data Processing and Validation, Core Physics and Operation Studies, Reactor Kinetics and Safety analysis, Reactor Noise Analysis and Radiation Transport and Shielding Studies. List of publication is given at the end. refs., figs., tabs

Activity report of Reactor Physics Division - 1993

Energy Technology Data Exchange (ETDEWEB)

Indira, R [ed.; Indira Gandhi Centre for Atomic Research, Kalpakkam (India)

1994-12-31

The research and development (R and D) activities of the Reactor Physics Division of Indira Gandhi Centre for Atomic Research (IGCAR), Kalpakkam during 1993 are reported. The activities are arranged under the headings: Nuclear Data Processing and validation, Core Physics and Operation Studies, Reactor Kinetics and Safety analysis, Reactor Noise Analysis and Radiation Transport and Shielding Studies. List of publication is given at the end. (author). refs., figs., tabs.

Modeling the PUSPATI TRIGA Reactor using MCNP code

International Nuclear Information System (INIS)

Mohamad Hairie Rabir; Mark Dennis Usang; Naim Syauqi Hamzah; Julia Abdul Karim; Mohd Amin Sharifuldin Salleh

2012-01-01

The 1 MW TRIGA MARK II research reactor at Malaysian Nuclear Agency achieved initial criticality on June 28, 1982. The reactor is designed to effectively implement the various fields of basic nuclear research, manpower training, and production of radioisotopes. This paper describes the reactor parameters calculation for the PUSPATI TRIGA REACTOR (RTP); focusing on the application of the developed reactor 3D model for criticality calculation, analysis of power and neutron flux distribution and depletion study of TRIGA fuel. The 3D continuous energy Monte Carlo code MCNP was used to develop a versatile and accurate full model of the TRIGA reactor. The model represents in detailed all important components of the core and shielding with literally no physical approximation. (author)

The research reactors their contribution to the reactors physics; Les reacteurs de recherche leur apport sur la physique des reacteurs

Energy Technology Data Exchange (ETDEWEB)

Barral, J C [Electricite de France (EDF), 75 - Paris (France); Zaetta, A [CEA/Cadarache, Direction des Reacteurs Nucleaires, DRN, 13 - Saint-Paul-lez-Durance (France); Johner, J [CEA/Cadarache, Dept. de Recherches sur la Fusion Controlee (DRFC), 13 - Saint Paul lez Durance (France); Mathoniere, G [CEA/Saclay, DEN, 91 - Gif sur Yvette (France); and others

2000-07-01

The 19 october 2000, the french society of nuclear energy organized a day on the research reactors. This associated report of the technical session, reactors physics, is presented in two parts. The first part deals with the annual meeting and groups general papers on the pressurized water reactors, the fast neutrons reactors and the fusion reactors industry. The second part presents more technical papers about the research programs, critical models, irradiation reactors (OSIRIS and Jules Horowitz) and computing tools. (A.L.B.)

A series of lectures on operational physics of power reactors

International Nuclear Information System (INIS)

Mohanakrishnan, P.; Rastogi, B.P.

1982-01-01

This report discusses certain aspects of operational physics of power reactors. These form a lecture series at the Winter College on Nuclear Physics and Reactors, Jan. - March 1980, conducted at the International Centre for Theoretical Physics, Trieste, Italy. The topics covered are (a) the reactor physics aspects of fuel burnup (b) theoretical methods applied for burnup prediction in power reactors (c) interpretation of neutron detector readings in terms of adjacent fuel assembly powers (d) refuelling schemes used in power reactors. The reactor types chosen for the discussion are BWR, PWR and PHWR. (author)

Fundamentals of Nuclear Reactor Physics

CERN Document Server

Lewis, E E

2008-01-01

This new streamlined text offers a one-semester treatment of the essentials of how the fission nuclear reactor works, the various approaches to the design of reactors, and their safe and efficient operation. The book includes numerous worked-out examples and end-of-chapter questions to help reinforce the knowledge presented. This textbook offers an engineering-oriented introduction to nuclear physics, with a particular focus on how those physics are put to work in the service of generating nuclear-based power, particularly the importance of neutron reactions and neutron behavior. Engin

Development of a three dimension multi-physics code for molten salt fast reactor

International Nuclear Information System (INIS)

Cheng Maosong; Dai Zhimin

2014-01-01

Molten Salt Reactor (MSR) was selected as one of the six innovative nuclear reactors by the Generation IV International Forum (GIF). The circulating-fuel in the can-type molten salt fast reactor makes the neutronics and thermo-hydraulics of the reactor strongly coupled and different from that of traditional solid-fuel reactors. In the present paper: a new coupling model is presented that physically describes the inherent relations between the neutron flux, the delayed neutron precursor, the heat transfer and the turbulent flow. Based on the model, integrating nuclear data processing, CAD modeling, structured and unstructured mesh technology, data analysis and visualization application, a three dimension steady state simulation code system (MSR3DS) for the can-type molten salt fast reactor is developed and validated. In order to demonstrate the ability of the code, the three dimension distributions of the velocity, the neutron flux, the delayed neutron precursor and the temperature were obtained for the simplified MOlten Salt Advanced Reactor Transmuter (MOSART) using this code. The results indicate that the MSR3DS code can provide a feasible description of multi-physical coupling phenomena in can-type molten salt fast reactor. Furthermore, the code can well predict the flow effect of fuel salt and the transport effect of the turbulent diffusion. (authors)

A fast and flexible reactor physics model for simulating neutron spectra and depletion in fast reactors - 202

International Nuclear Information System (INIS)

Recktenwald, G.D.; Bronk, L.A.; Deinert, M.R.

2010-01-01

Determining the time dependent concentration of isotopes within a nuclear reactor core is central to the analysis of nuclear fuel cycles. We present a fast, flexible tool for determining the time dependent neutron spectrum within fast reactors. The code (VBUDS: visualization, burnup, depletion and spectra) uses a two region, multigroup collision probability model to simulate the energy dependent neutron flux and tracks the buildup and burnout of 24 actinides, as well as fission products. While originally developed for LWR simulations, the model is shown to produce fast reactor spectra that show high degree of fidelity to available fast reactor benchmarks. (authors)

IRPhEP-handbook, International Handbook of Evaluated Reactor Physics Benchmark Experiments

International Nuclear Information System (INIS)

Sartori, Enrico; Blair Briggs, J.

2008-01-01

1 - Description: The purpose of the International Reactor Physics Experiment Evaluation Project (IRPhEP) is to provide an extensively peer-reviewed set of reactor physics-related integral data that can be used by reactor designers and safety analysts to validate the analytical tools used to design next-generation reactors and establish the safety basis for operation of these reactors. This work of the IRPhEP is formally documented in the 'International Handbook of Evaluated Reactor Physics Benchmark Experiments,' a single source of verified and extensively peer-reviewed reactor physics benchmark measurements data. The IRPhE Handbook is available on DVD. You may request a DVD by completing the DVD Request Form available at: http://irphep.inl.gov/handbook/hbrequest.shtml The evaluation process entails the following steps: 1. Identify a comprehensive set of reactor physics experimental measurements data, 2. Evaluate the data and quantify overall uncertainties through various types of sensitivity analysis to the extent possible, verify the data by reviewing original and subsequently revised documentation, and by talking with the experimenters or individuals who are familiar with the experimental facility, 3. Compile the data into a standardized format, 4. Perform calculations of each experiment with standard reactor physics codes where it would add information, 5. Formally document the work into a single source of verified and peer reviewed reactor physics benchmark measurements data. The International Handbook of Evaluated Reactor Physics Benchmark Experiments contains reactor physics benchmark specifications that have been derived from experiments that were performed at various nuclear experimental facilities around the world. The benchmark specifications are intended for use by reactor physics personal to validate calculational techniques. The 2008 Edition of the International Handbook of Evaluated Reactor Physics Experiments contains data from 25 different

Benchmarking lattice physics data and methods for boiling water reactor analysis

International Nuclear Information System (INIS)

Cacciapouti, R.J.; Edenius, M.; Harris, D.R.; Hebert, M.J.; Kapitz, D.M.; Pilat, E.E.; VerPlanck, D.M.

1983-01-01

The objective of the work reported was to verify the adequacy of lattice physics modeling for the analysis of the Vermont Yankee BWR using a multigroup, two-dimensional transport theory code. The BWR lattice physics methods have been benchmarked against reactor physics experiments, higher order calculations, and actual operating data

PIK3CA, HRAS and PTEN in human papillomavirus positive oropharyngeal squamous cell carcinoma

International Nuclear Information System (INIS)

Chiosea, Simion I; Nikiforova, Marina N; Grandis, Jennifer R; Lui, Vivian W Y; Diergaarde, Brenda; Maxwell, Jessica H; Ferris, Robert L; Kim, Seungwon W; Luvison, Alyssa; Miller, Megan

2013-01-01

Recent genomic evidence suggests frequent phosphatidylinositide 3-kinase (PI3K) pathway activation in human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma. Mutations/amplification of the gene encoding p110α catalytic subunit of phosphoinositide 3-kinase (PIK3CA), loss of phosphatase and tensin homolog (PTEN) and HRAS mutations are known to activate PI3K pathway. PIK3CA mutations were identified by Sanger sequencing in 23 of 75 (31%) HPV-positive oropharyngeal carcinomas, including exon 9 (p.E545K [n = 10] and p.E542K [n = 5]) or exon 20 (p.H1047Y, n = 2) mutations. Five rare and one novel (p.R537Q) PIK3CA mutations were identified. HRAS mutation (p.Q61L) was detected in 1 of 62 tested cases. PIK3CA amplification by fluorescence in situ hybridization (FISH) was identified in 4 cases (4/21, 20%), while PTEN loss was seen in 7 (7/21, 33%) cases (chromosome 10 monosomy [n = 4], homozygous deletion [n = 3]). Overall, genetic alterations that likely lead to PI3K pathway activation were identified in 34 of 75 cases (45%) and did not correlate with disease specific survival. These findings offer a molecular rationale for therapeutic targeting of PI3K pathway in patients with HPV-positive oropharyngeal carcinoma

Proceedings of 2. Yugoslav symposium on reactor physics, Part 3, Herceg Novi (Yugoslavia), 27-29 Sep 1966

International Nuclear Information System (INIS)

1966-01-01

This Volume 3 of the Proceedings of 2. Yugoslav symposium on reactor physics includes three papers describing the following: model for spatial synthesis of automated control system of the GCR type reactor; model for analysis of hydrodynamic processes at the BHWR type reactors; mathematical model for safety analysis of heavy water power reactor

The sensitivity and efficacy method of PIK3CA exon 9 E545A as a high diagnostic accuracy in breast cancer

Directory of Open Access Journals (Sweden)

Desriani

2018-06-01

Full Text Available The phosphatidylinositol 3-kinases (PIK3s are lipid kinases. Mutation in the exon 9 and exon 20 determined as a predictive factor in anti-HER-2 therapy. In some countries, such as Singapore, China, and Peru, PIK3CA exon 9 E545A was reported to produce the highest rate of mutation. In this research, we developed and optimized PIK3CA exon 9 E545A detection methods with intercalating dye SYBR Green I based on the Tm Shift approach by using prepared recombinant plasmid pGEMT-easy PIK3CA exon 9 and PIK3CA exon 9 E545A. Recombinant plasmid was used due to the limited number of samples. Methods: Recombinant plasmid was prepared based on manufactured procedures, and this process was then followed by Tm prediction with Poland software, Tm Shift SYBR Green I development, and its characterization (reproducibility, repeatability, sensitivity, qPCR efficiency, and qPCR amplification, respectively. Result: A method for PIK3CA E545A detection based on TM shift SYBR Green I has been successfully developed. The melting temperature for PIK3CA exon 9 was 78.1 ± 0.1 °C, while that for PIK3CA exon E545A was 80.20 °C. The Tm of mutant was the same as that predicted using Polland Software. The reproducibility of the methods was high, with the coefficient values for inter and intra assays were below 10% with a high sensitivity at 1%, while R2 0.99 and PCR efficiency was 97.75%. Conclusion: The results presented here demonstrate that the PIK3CA exon 9 E545A detection method has a good sensitivity and efficacy assay, which proves that the method has a high diagnostic accuracy in breast cancer. Keywords: SYBR Green I, PIK3CA E545A, Breast cancer, Real time PCR, Recombinant plasmid

Modelization of physical phenomena in research reactors with the help of new developments in transport methods, and methodology validation with experimental data

International Nuclear Information System (INIS)

Rauck, St.

2000-10-01

The aim of this work is to develop a scheme for experimental reactors, based on transport equations. This type of reactors is characterized by a small core, a complex, very heterogeneous geometry and a large leakage. The possible insertion of neutron beams in the reflector and the presence of absorbers in the core increase the difficulty of the 3D-geometrical description and the physical modeling of the component parameters of the reactor. The Orphee reactor has been chosen for our study. Physical models (homogenization, collapsing cross section in few groups, albedo multigroup condition) have been developed in the APOLLO2 and CRONOS2 codes to calculate flux and power maps in a 3D-geometry, with different burnup and through transport equations. Comparisons with experimental measurements have shown the interest of taking into account anisotropy, steep flux gradients by using Sn methods, and on the other hand using a 12-group cross section library. The modeling of neutron beams has been done outside the core modeling through Monte Carlo calculations and with the total geometry, including a large thickness of heavy water. Thanks to this calculations, one can evaluate the neutron beams anti-reactivity and determinate the core cycle. We assure these methods more accurate than usual transport-diffusion calculations will be used for the conception of new research reactors. (author)

Multi-physic simulations of irradiation experiments in a technological irradiation reactor

International Nuclear Information System (INIS)

Bonaccorsi, Th.

2007-09-01

A Material Testing Reactor (MTR) makes it possible to irradiate material samples under intense neutron and photonic fluxes. These experiments are carried out in experimental devices localised in the reactor core or in periphery (reflector). Available physics simulation tools only treat, most of the time, one physics field in a very precise way. Multi-physic simulations of irradiation experiments therefore require a sequential use of several calculation codes and data exchanges between these codes: this corresponds to problems coupling. In order to facilitate multi-physic simulations, this thesis sets up a data model based on data-processing objects, called Technological Entities. This data model is common to all of the physics fields. It permits defining the geometry of an irradiation device in a parametric way and to associate information about materials to it. Numerical simulations are encapsulated into interfaces providing the ability to call specific functionalities with the same command (to initialize data, to launch calculations, to post-treat, to get results,... ). Thus, once encapsulated, numerical simulations can be re-used for various studies. This data model is developed in a SALOME platform component. The first application case made it possible to perform neutronic simulations (OSIRIS reactor and RJH) coupled with fuel behavior simulations. In a next step, thermal hydraulics could also be taken into account. In addition to the improvement of the calculation accuracy due to the physical phenomena coupling, the time spent in the development phase of the simulation is largely reduced and the possibilities of uncertainty treatment are under consideration. (author)

Plasma Reactors and Plasma Thrusters Modeling by Ar Complete Global Models

Directory of Open Access Journals (Sweden)

Chloe Berenguer

2012-01-01

Full Text Available A complete global model for argon was developed and adapted to plasma reactor and plasma thruster modeling. It takes into consideration ground level and excited Ar and Ar+ species and the reactor and thruster form factors. The electronic temperature, the species densities, and the ionization percentage, depending mainly on the pressure and the absorbed power, have been obtained and commented for various physical conditions.

Modeling atmospheric dispersion for reactor accident consequence evaluation

International Nuclear Information System (INIS)

Alpert, D.J.; Gudiksen, P.H.; Woodard, K.

1982-01-01

Atmospheric dispersion models are a central part of computer codes for the evaluation of potential reactor accident consequences. A variety of ways of treating to varying degrees the many physical processes that can have an impact on the predicted consequences exists. The currently available models are reviewed and their capabilities and limitations, as applied to reactor accident consequence analyses, are discussed

Significance of PIK3CA Mutations in Patients with Early Breast Cancer Treated with Adjuvant Chemotherapy: A Hellenic Cooperative Oncology Group (HeCOG Study.

Directory of Open Access Journals (Sweden)

George Papaxoinis

Full Text Available The PI3K-AKT pathway is frequently activated in breast cancer. PIK3CA mutations are most frequently found in the helical (exon 9 and kinase (exon 20 domains of this protein. The aim of the present study was to examine the role of different types of PIK3CA mutations in combination with molecular biomarkers related to PI3K-AKT signaling in patients with early breast cancer.Tumor tissue samples from 1008 early breast cancer patients treated with adjuvant chemotherapy in two similar randomized trials of HeCOG were examined. Tumors were subtyped with immunohistochemistry (IHC and FISH for ER, PgR, Ki67, HER2 and androgen receptor (AR. PIK3CA mutations were analyzed by Sanger sequencing (exon 20 and qPCR (exon 9 (Sanger/qPCR mutations. In 610 cases, next generation sequencing (NGS PIK3CA mutation data were also available. PIK3CA mutations and PTEN protein expression (IHC were analyzed in luminal tumors (ER and/or PgR positive, molecular apocrine carcinomas (MAC; ER/PgR negative / AR positive and hormone receptor (ER/PgR/AR negative tumors.PIK3CA mutations were detected in 235/1008 tumors (23% with Sanger/qPCR and in 149/610 tumors (24% with NGS. Concordance between the two methods was good with a Kappa coefficient of 0.76 (95% CI 0.69-0.82. Lobular histology, low tumor grade and luminal A tumors were associated with helical domain mutations (PIK3CAhel, while luminal B with kinase domain mutations (PIK3CAkin. The overall incidence of PIK3CA mutations was higher in luminal as compared to MAC and hormone receptor negative tumors (p = 0.004. Disease-free and overall survival did not significantly differ with respect to PIK3CA mutation presence and type. However, a statistically significant interaction between PIK3CA mutation status and PTEN low protein expression with regard to prognosis was identified.The present study did not show any prognostic significance of specific PIK3CA mutations in a large group of predominantly lymph-node positive breast cancer

Progress of the DUPIC fuel compatibility analysis (I) - reactor physics

Energy Technology Data Exchange (ETDEWEB)

Choi, Hang Bok; Jeong, Chang Joon; Roh, Gyu Hong; Rhee, Bo Wook; Park, Jee Won

2003-12-01

Since 1992, the direct use of spent pressurized water reactor fuel in CANada Deuterium Uranium (CANDU) reactors (DUPIC) has been studied as an alternative to the once-through fuel cycle. The DUPIC fuel cycle study is focused on the technical feasibility analysis, the fabrication of DUPIC fuels for irradiation tests and the demonstration of the DUPIC fuel performance. The feasibility analysis was conducted for the compatibility of the DUPIC fuel with existing CANDU-6 reactors from the viewpoints of reactor physics, reactor safety, fuel cycle economics, etc. This study has summarized the intermediate results of the DUPIC fuel compatibility analysis, which includes the CANDU reactor physics design requirements, DUPIC fuel core physics design method, performance of the DUPIC fuel core, regional overpower trip setpoint, and the CANDU primary shielding. The physics analysis showed that the CANDU-6 reactor can accommodate the DUPIC fuel without deteriorating the physics design requirements by adjusting the fuel management scheme if the fissile content of the DUPIC fuel is tightly controlled.

Operational power reactor health physics

International Nuclear Information System (INIS)

Watson, B.A.

1987-01-01

Operational Health Physics can be comprised of a multitude of organizations, both corporate and at the plant sites. The following discussion centers around Baltimore Gas and Electric's (BG and E) Calvert Cliffs Nuclear Power Plant, located in Lusby, Maryland. Calvert Cliffs is a twin Combustion Engineering 825 MWe pressurized water reactor site with Unit I having a General electric turbine-generator and Unit II having a Westinghouse turbine-generator. Having just completed each Unit's ten-year Inservice Inspection and Refueling Outge, a total of 20 reactor years operating health physics experience have been accumulated at Calvert Cliffs. Because BG and E has only one nuclear site most health physics functions are performed at the plant site. This is also true for the other BG and E nuclear related organizations, such as Engineering and Quality Assurance. Utilities with multiple plant sites have corporate health physics entity usually providing oversight to the various plant programs

An Overview of the International Reactor Physics Experiment Evaluation Project

International Nuclear Information System (INIS)

Briggs, J. Blair; Gulliford, Jim

2014-01-01

Interest in high-quality integral benchmark data is increasing as efforts to quantify and reduce calculational uncertainties associated with advanced modeling and simulation accelerate to meet the demands of next generation reactor and advanced fuel cycle concepts. Two Organization for Economic Cooperation and Development (OECD) Nuclear Energy Agency (NEA) activities, the International Criticality Safety Benchmark Evaluation Project (ICSBEP), initiated in 1992, and the International Reactor Physics Experiment Evaluation Project (IRPhEP), initiated in 2003, have been identifying existing integral experiment data, evaluating those data, and providing integral benchmark specifications for methods and data validation for nearly two decades. Data provided by those two projects will be of use to the international reactor physics, criticality safety, and nuclear data communities for future decades. An overview of the IRPhEP and a brief update of the ICSBEP are provided in this paper.

Recent BWR fuel management reactor physics advances

International Nuclear Information System (INIS)

Crowther, R.L.; Congdon, S.P.; Crawford, B.W.; Kang, C.M.; Martin, C.L.; Reese, A.P.; Savoia, P.J.; Specker, S.R.; Welchly, R.

1982-01-01

Improvements in BWR fuel management have been under development to reduce uranium and separative work (SWU) requirements and reduce fuel cycle costs, while also maintaining maximal capacity factors and high fuel reliability. Improved reactor physics methods are playing an increasingly important role in making such advances feasible. The improved design, process computer and analysis methods both increase knowledge of the thermal margins which are available to implement fuel management advance, and improve the capability to reliably and efficiently analyze and design for fuel management advances. Gamma scan measurements of the power distributions of advanced fuel assembly and advanced reactor core designs, and improved in-core instruments also are important contributors to improving 3-d predictive methods and to increasing thermal margins. This paper is an overview of the recent advances in BWR reactor physics fuel management methods, coupled with fuel management and core design advances. The reactor physics measurements which are required to confirm the predictions of performance fo fuel management advances also are summarized

Ad hoc committee on reactor physics benchmarks

International Nuclear Information System (INIS)

Diamond, D.J.; Mosteller, R.D.; Gehin, J.C.

1996-01-01

In the spring of 1994, an ad hoc committee on reactor physics benchmarks was formed under the leadership of two American Nuclear Society (ANS) organizations. The ANS-19 Standards Subcommittee of the Reactor Physics Division and the Computational Benchmark Problem Committee of the Mathematics and Computation Division had both seen a need for additional benchmarks to help validate computer codes used for light water reactor (LWR) neutronics calculations. Although individual organizations had employed various means to validate the reactor physics methods that they used for fuel management, operations, and safety, additional work in code development and refinement is under way, and to increase accuracy, there is a need for a corresponding increase in validation. Both organizations thought that there was a need to promulgate benchmarks based on measured data to supplement the LWR computational benchmarks that have been published in the past. By having an organized benchmark activity, the participants also gain by being able to discuss their problems and achievements with others traveling the same route

CLOVES syndrome: review of a PIK3CA-related overgrowth spectrum (PROS).

Science.gov (United States)

Martinez-Lopez, A; Blasco-Morente, G; Perez-Lopez, I; Herrera-Garcia, J D; Luque-Valenzuela, M; Sanchez-Cano, D; Lopez-Gutierrez, J C; Ruiz-Villaverde, R; Tercedor-Sanchez, J

2017-01-01

Overgrowth syndromes are characterized by global or localized disproportionate growth associated with other anomalies, including vascular malformations and neurological and/or visceral disorders. CLOVES (Congenital Lipomatous asymmetric Overgrowth of the trunk with lymphatic, capillary, venous, and combined-type Vascular malformations, Epidermal naevi, Scoliosis/Skeletal and spinal anomalies) is an overgrowth syndrome caused by mosaic activating mutation in gene PIK3CA, which gives rise to abnormal PI3K-AKT-mTOR pathway activation. These mutations are responsible for the clinical manifestations of the syndrome, which include low- and high-flow vascular malformations, thoracic lipomatous hyperplasia, asymmetric growth, and visceral and neurological disorders. These common anomalies are illustrated with figures from two personal cases. Identification of the clinical and genetic characteristics of CLOVES syndrome is crucial for the differential diagnosis with other overgrowth syndromes, such as Proteus or Klippel-Trenaunay (K-T) syndromes, and for the therapeutic management of the different anomalies. In this context, a new entity comprising different syndromes with phenotypic mutations in PIK3CA has been proposed, designated PIK3CA-related overgrowth spectrum (PROS), with the aim of facilitating clinical management and establishing appropriate genetic study criteria. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Introduction to nuclear power reactors and their health physics systems

International Nuclear Information System (INIS)

Brtis, J.S.

1982-01-01

This paper provides an introduction to: (1) the major systems of Boiling Water Reactors (BWR's) and Pressurized Water Reactors (PWR's), (2) the production and distribution of radiation sources in BWR's and PWR's, (3) the regulatory and functional requirements for nuclear power reactor design from a health physics standpoint, (4) the health physics systems provided to meet such requirements, and (5) a bibliography of documents germane to power reactor health physics design

A model for nuclear research reactor dynamics

Energy Technology Data Exchange (ETDEWEB)

Barati, Ramin, E-mail: Barati.ramin@aut.ac.ir; Setayeshi, Saeed, E-mail: setayesh@aut.ac.ir

2013-09-15

Highlights: • A thirty-fourth order model is used to simulate the dynamics of a research reactor. • We consider delayed neutrons fraction as a function of time. • Variable fuel and temperature reactivity coefficients are used. • WIMS, BORGES and CITVAP codes are used for initial condition calculations. • Results are in agreement with experimental data rather than common codes. -- Abstract: In this paper, a useful thirty-fourth order model is presented to simulate the kinetics and dynamics of a research reactor core. The model considers relevant physical phenomena that govern the core such as reactor kinetics, reactivity feedbacks due to coolant and fuel temperatures (Doppler effects) with variable reactivity coefficients, xenon, samarium, boron concentration, fuel burn up and thermal hydraulics. WIMS and CITVAP codes are used to extract neutron cross sections and calculate the initial neuron flux respectively. The purpose is to present a model with results similar to reality as much as possible with reducing common simplifications in reactor modeling to be used in different analyses such as reactor control, functional reliability and safety. The model predictions are qualified by comparing with experimental data, detailed simulations of reactivity insertion transients, and steady state for Tehran research reactor reported in the literature and satisfactory results have been obtained.

EBR-II Reactor Physics Benchmark Evaluation Report

Energy Technology Data Exchange (ETDEWEB)

Pope, Chad L. [Idaho State Univ., Pocatello, ID (United States); Lum, Edward S [Idaho State Univ., Pocatello, ID (United States); Stewart, Ryan [Idaho State Univ., Pocatello, ID (United States); Byambadorj, Bilguun [Idaho State Univ., Pocatello, ID (United States); Beaulieu, Quinton [Idaho State Univ., Pocatello, ID (United States)

2017-12-28

This report provides a reactor physics benchmark evaluation with associated uncertainty quantification for the critical configuration of the April 1986 Experimental Breeder Reactor II Run 138B core configuration.

Physics and safety of advanced research reactors

International Nuclear Information System (INIS)

Boening, K.; Hardt, P. von der

1987-01-01

Advanced research reactor concepts are presently being developed in order to meet the neutron-based research needs of the nineties. Among these research reactors, which are characterized by an average power density of 1-10 MW per liter, highest priority is now generally given to the 'beam tube reactors'. These provide very high values of the thermal neutron flux (10 14 -10 16 cm -2 s -1 ) in a large volume outside of the reactor core, which can be used for sample irradiations and, in particular, for neutron scattering experiments. The paper first discusses the 'inverse flux trap concept' and the main physical aspects of the design and optimization of beam tube reactors. After that two examples of advanced research reactor projects are described which may be considered as two opposite extremes with respect to the physical optimization principle just mentioned. The present situation concerning cross section libraries and neutronic computer codes is more or less satisfactory. The safety analyses of advanced research reactors can largely be updated from those of current new designs, partially taking advantage of the immense volume of work done for power reactors. The paper indicates a few areas where generic problems for advanced research reactor safety are to be solved. (orig.)

Development of physical conceptions of fast reactors

International Nuclear Information System (INIS)

Khomyakov, Yu.S.; Matveev, V.I.; Moiseev, A.V.

2013-01-01

• Russian experience in developing fast reactors has proved clearly scientific justification of conceptual physical principles and their technical feasibility. • However, the potential of fast reactors caused by their physical features has not been fully realized. • In order to assure the real possibility of transition to the nuclear power with fast reactors by about 2030 it is necessary to consistently update fast reactor designs for solving the following key problems: - increasing of self-protection level of reactor core; - improvement of technical and economical characteristics; - solution of the problems related to the fuel supply of nuclear power and assimilation of closed nuclear fuel cycle; - disposal of long lived radioactive waste and transmutation of minor actinides. • Russian program (2010-2020) on the development of basic concepts of the new generation reactors implies successive solution of the above problems. • New technical decisions will be demonstrated by development and assimilation of the new reactors: - BN-800 – development of the fuel cycle infrastructure and mastering of the new types of fuel; - BN-1200 reactor – demonstration economical efficiency of fast reactor and new level of safety; - BREST development and demonstration new heavy liquid metal coolant technology and alternative design concept

3D CAD model of the subcritical nuclear reactor of IPN

International Nuclear Information System (INIS)

Pahuamba V, F. de J.; Delfin L, A.; Gomez T, A.; Ibarra R, G.; Del Valle G, E.; Sanchez R, A.

2016-09-01

The three-dimensional (3D) CAD model of the subcritical reactor Chicago model 9000 of Instituto Politecnico Nacional (IPN) allows obtaining a 3D view with the dimensions of each of its components, such as: natural uranium cylindrical rods, fuel elements, hexagonal reactor core arrangement, cylindrical stainless steel tank containing the core, fuel element support grids and reactor water cleaning system. As a starting point for the development of the model, the Chicago model 9000 subcritical reactor manual provided by the manufacturer was used, the measurement and verification of the components to adapt the geometric, physical and mechanical characteristics was carried out and materials standards were used to obtain a design that allows to elaborate a new manual according to the specifications. In addition, the 3D models of the building of the Advanced Physics Laboratory, neutron generator, cobalt source and the corridors connecting to the subcritical reactor facility were developed, allowing an animated ride, developed by computer-aided design software. The manual provided by the company Nuclear Chicago, dates from the year 1959 and presents diverse deviations in the design and dimensions of the reactor components. The model developed; in addition to supporting the development of the new manual represents a learning tool to visualize the reactor components. (Author)

Stochastic processes analysis in nuclear reactor using ARMA models

International Nuclear Information System (INIS)

Zavaljevski, N.

1990-01-01

The analysis of ARMA model derived from general stochastic state equations of nuclear reactor is given. The dependence of ARMA model parameters on the main physical characteristics of RB nuclear reactor in Vinca is presented. Preliminary identification results are presented, observed discrepancies between theory and experiment are explained and the possibilities of identification improvement are anticipated. (author)

Physical model of lean suppression pressure oscillation phenomena: steam condensation in the light water reactor pressure suppression system (PSS)

International Nuclear Information System (INIS)

McCauley, E.W.; Holman, G.S.; Aust, E.; Schwan, H.; Vollbrandt, J.

1980-01-01

Using the results of large scale multivent tests conducted by GKSS, a physical model of chugging is developed. The unique combination of accurate digital data and cinematic data has provided the derivation of a detailed, quantified correlation between the dynamic physical variables and the associated two-phase thermo-hydraulic phenomena occurring during lean suppression (chugging) phases of the loss-of-coolant accident in a boiling water reactor pressure suppression system

Advances in Reactor Physics, Mathematics and Computation. Volume 2

Energy Technology Data Exchange (ETDEWEB)

1987-01-01

These proceedings of the international topical meeting on advances in reactor physics, mathematics and computation, Volume 2, are divided into 7 sessions bearing on: - session 7: Deterministic transport methods 1 (7 conferences), - session 8: Interpretation and analysis of reactor instrumentation (6 conferences), - session 9: High speed computing applied to reactor operations (5 conferences), - session 10: Diffusion theory and kinetics (7 conferences), - session 11: Fast reactor design, validation and operating experience (8 conferences), - session 12: Deterministic transport methods 2 (7 conferences), - session 13: Application of expert systems to physical aspects of reactor design and operation.

Effect of Drawer Master Modeling of ZPPR15 Phase A Reactor Physics Experiment on Integral Parameter

International Nuclear Information System (INIS)

Yoo, Jae Woon; Kim, Sang Ji

2011-01-01

As a part of an International-Nuclear Engineering Research Initiative (I-NERI) Project, KAERI and ANL are analyzing the ZPPR-15 reactor physics experiments. The ZPPR-15 experiments were carried out in support of the Integral Fast Reactor (IFR) project. Because of lack of the experimental data, verifying and validating the core neutronics analysis code for metal fueled sodium cooled fast reactors (SFR) has been one of the big concerns. KAERI is developing the metal fuel loaded SFR and plans to construct the demonstration SFR by around 2028. Database built through this project and its result of analysis will play an important role in validating the SFR neutronics characteristics. As the first year work of I-NERI project, KAERI analyzed ZPPR-15 Phase A experiment among four phases (Phase A to D). The effect of a drawer master modeling on the integral parameter was investigated. The approximated benchmark configurations for each loading were constructed to be used for validating a deterministic code

An overview of reactor physics standards: Past, present and future

International Nuclear Information System (INIS)

Cokinos, D.M.

1992-07-01

This report discusses for determining key static reactor physics parameters which have been developed by groups of experts (working groups) under the aegis of ANS-19, the ANS Reactor Physics Standards Committee. Following a series of sequential reviews, augmented by feedback from potential users, a proposed standard is brought into final form by the working group before it is adopted as a formal standard by the American National Standards Institute (ANSI); Reactor Physics standards are intended to provide guidance in the performance and qualification of complex sequences of reactor calculations and/or measurements and are regularly reviewed for possible updates and/or revisions. The reactor physics standards developed to date are listed and standards now being developed by the respective working groups are also provided

Probabilistic risk assessment for a loss of coolant accident in McMaster Nuclear Reactor and application of reliability physics model for modeling human reliability

Science.gov (United States)

Ha, Taesung

A probabilistic risk assessment (PRA) was conducted for a loss of coolant accident, (LOCA) in the McMaster Nuclear Reactor (MNR). A level 1 PRA was completed including event sequence modeling, system modeling, and quantification. To support the quantification of the accident sequence identified, data analysis using the Bayesian method and human reliability analysis (HRA) using the accident sequence evaluation procedure (ASEP) approach were performed. Since human performance in research reactors is significantly different from that in power reactors, a time-oriented HRA model (reliability physics model) was applied for the human error probability (HEP) estimation of the core relocation. This model is based on two competing random variables: phenomenological time and performance time. The response surface and direct Monte Carlo simulation with Latin Hypercube sampling were applied for estimating the phenomenological time, whereas the performance time was obtained from interviews with operators. An appropriate probability distribution for the phenomenological time was assigned by statistical goodness-of-fit tests. The human error probability (HEP) for the core relocation was estimated from these two competing quantities: phenomenological time and operators' performance time. The sensitivity of each probability distribution in human reliability estimation was investigated. In order to quantify the uncertainty in the predicted HEPs, a Bayesian approach was selected due to its capability of incorporating uncertainties in model itself and the parameters in that model. The HEP from the current time-oriented model was compared with that from the ASEP approach. Both results were used to evaluate the sensitivity of alternative huinan reliability modeling for the manual core relocation in the LOCA risk model. This exercise demonstrated the applicability of a reliability physics model supplemented with a. Bayesian approach for modeling human reliability and its potential

IGORR 2: Proceedings of the 2. meeting of the International Group On Research Reactors

Energy Technology Data Exchange (ETDEWEB)

NONE

1992-07-01

The International group on Research Reactors was formed to facilitate the sharing of knowledge and experience among those institutions and individuals who are actively working to design, build, and promote new research reactors or to make significant upgrades to existing facilities. Sessions during this second meeting were devoted to research reactor reports (GRENOBLE reactor, FRM-II, HIFAR, PIK, reactors at JAERI, MAPLE, ANS, NIST, MURR, TRIGA, BR-2, SIRIUS 2); other neutron sources; and two workshops were dealing with research and development results and needs and reports on progress in needed of R and D areas identified at IGORR 1.

IGORR 2: Proceedings of the 2. meeting of the International Group On Research Reactors

International Nuclear Information System (INIS)

1992-01-01

The International group on Research Reactors was formed to facilitate the sharing of knowledge and experience among those institutions and individuals who are actively working to design, build, and promote new research reactors or to make significant upgrades to existing facilities. Sessions during this second meeting were devoted to research reactor reports (GRENOBLE reactor, FRM-II, HIFAR, PIK, reactors at JAERI, MAPLE, ANS, NIST, MURR, TRIGA, BR-2, SIRIUS 2); other neutron sources; and two workshops were dealing with research and development results and needs and reports on progress in needed of R and D areas identified at IGORR 1

Physics of pressurized water reactors

International Nuclear Information System (INIS)

Gruen, A.

1980-01-01

The objective of this lecture is to demonstrate typical problems and solutions encountered in the design and operation of PWR power plants. The examples selected for illustration refer to PWR's of KWU design and to results of KWU design methods. In order to understand the physics of a power reactor it is necessary to have some knowledge of the structure and design of the power plant system of which the reactor is a part. It is therefore assumed that the reader is familiar with the design of the more important components and systems of a PWR, such as fuel assemblies, control assemblies, core lay-out, reactor coolant system, instrumentation. (author)

The reactor physics computer programs in PC's era

International Nuclear Information System (INIS)

Nainer, O.; Serghiuta, D.

1995-01-01

The main objective of reactor physics analysis is the evaluation of flux and power distribution over the reactor core. For CANDU reactors sophisticated computer programs, such as FMDP and RFSP, were developed 20 years ago for mainframe computers. These programs were adapted to work on workstations with UNIX or DOS, but they lack a feature that could improve their use and that is 'user friendly'. For using these programs the users need to deal with a great amount of information contained in sophisticated files. To modify a model is a great challenge. First of all, it is necessary to bear in mind all the geometrical dimensions and accordingly, to modify the core model to match the new requirements. All this must be done in a line input file. For a DOS platform, using an average performance PC system, could it be possible: to represent and modify all the geometrical and physical parameters in a meaningful way, on screen, using an intuitive graphic user interface; to reduce the real time elapsed in order to perform complex fuel-management analysis 'at home'; to avoid the rewrite of the mainframe version of the program? The author's answer is a fuel-management computer package operating on PC, 3 time faster than on a CDC-Cyber 830 mainframe one (486DX/33MHz/8MbRAM) or 20 time faster (Pentium-PC), respectively. (author). 5 refs., 1 tab., 5 figs

Validation of High-Fidelity Reactor Physics Models for Support of the KJRR Experimental Campaign in the Advanced Test Reactor

Energy Technology Data Exchange (ETDEWEB)

Nigg, David W. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Nielsen, Joseph W. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Norman, Daren R. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2017-07-01

The Korea Atomic Energy Research Institute is currently in the process of qualifying a Low-Enriched Uranium fuel element design for the new Ki-Jang Research Reactor (KJRR). As part of this effort, a prototype KJRR fuel element was irradiated for several operating cycles in the Northeast Flux Trap of the Advanced Test Reactor (ATR) at the Idaho National Laboratory. The KJRR fuel element contained a very large quantity of fissile material (618g 235U) in comparison with historical ATR experiment standards (<1g 235U), and its presence in the ATR flux trap was expected to create a neutronic configuration that would be well outside of the approved validation envelope for the reactor physics analysis methods used to support ATR operations. Accordingly it was necessary, prior to high-power irradiation of the KJRR fuel element in the ATR, to conduct an extensive set of new low-power physics measurements with the KJRR fuel element installed in the ATR Critical Facility (ATRC), a companion facility to the ATR that is located in an immediately adjacent building, sharing the same fuel handling and storage canal. The new measurements had the objective of expanding the validation envelope for the computational reactor physics tools used to support ATR operations and safety analysis to include the planned KJRR irradiation in the ATR and similar experiments that are anticipated in the future. The computational and experimental results demonstrated that the neutronic behavior of the KJRR fuel element in the ATRC is well-understood, both in terms of its general effects on core excess reactivity and fission power distributions, its effects on the calibration of the core lobe power measurement system, as well as in terms of its own internal fission rate distribution and total fission power per unit ATRC core power. Taken as a whole, these results have significantly extended the ATR physics validation envelope, thereby enabling an entire new class of irradiation experiments.

Advances in Reactor Physics, Mathematics and Computation. Volume 1

Energy Technology Data Exchange (ETDEWEB)

1987-01-01

These proceedings of the international topical meeting on advances in reactor physics, mathematics and computation, volume one, are divided into 6 sessions bearing on: - session 1: Advances in computational methods including utilization of parallel processing and vectorization (7 conferences) - session 2: Fast, epithermal, reactor physics, calculation, versus measurements (9 conferences) - session 3: New fast and thermal reactor designs (9 conferences) - session 4: Thermal radiation and charged particles transport (7 conferences) - session 5: Super computers (7 conferences) - session 6: Thermal reactor design, validation and operating experience (8 conferences).

New trends in reactor physics design methods

International Nuclear Information System (INIS)

Jagannathan, V.

1993-01-01

Reactor physics design methods are aimed at safe and efficient management of nuclear materials in a reactor core. The design methodologies require a high level of integration of different calculational modules of many a key areas like neutronics, thermal hydraulics, radiation transport etc in order to follow different 3-D phenomena under normal and transient operating conditions. The evolution of computer hardware technology is far more rapid than the software development and has rendered such integration a meaningful and realizable proposition. The aim of this paper is to assess the state of art of the physics design codes used in Indian thermal power reactor applications with respect to meeting the design, operational and safety requirements. (author). 50 refs

3D CAD model of the subcritical nuclear reactor of IPN; Modelo CAD 3D del reactor nuclear subcritico del IPN

Energy Technology Data Exchange (ETDEWEB)

Pahuamba V, F. de J.; Delfin L, A.; Gomez T, A. [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico); Ibarra R, G.; Del Valle G, E.; Sanchez R, A., E-mail: narehc@hotmail.com [IPN, Escuela Superior de Fisica y Matematicas, Av. IPN, Edif. 9, Unidad Profesional Adolfo Lopez Mateos, San Pedro Zacatenco, 07738 Ciudad de Mexico (Mexico)

2016-09-15

The three-dimensional (3D) CAD model of the subcritical reactor Chicago model 9000 of Instituto Politecnico Nacional (IPN) allows obtaining a 3D view with the dimensions of each of its components, such as: natural uranium cylindrical rods, fuel elements, hexagonal reactor core arrangement, cylindrical stainless steel tank containing the core, fuel element support grids and reactor water cleaning system. As a starting point for the development of the model, the Chicago model 9000 subcritical reactor manual provided by the manufacturer was used, the measurement and verification of the components to adapt the geometric, physical and mechanical characteristics was carried out and materials standards were used to obtain a design that allows to elaborate a new manual according to the specifications. In addition, the 3D models of the building of the Advanced Physics Laboratory, neutron generator, cobalt source and the corridors connecting to the subcritical reactor facility were developed, allowing an animated ride, developed by computer-aided design software. The manual provided by the company Nuclear Chicago, dates from the year 1959 and presents diverse deviations in the design and dimensions of the reactor components. The model developed; in addition to supporting the development of the new manual represents a learning tool to visualize the reactor components. (Author)

Study on Reactor Physics Characteristic of the PWR Core Using UO2

International Nuclear Information System (INIS)

Tukiran Surbakti

2009-01-01

Study on reactor physics characteristic of the PWR core using UO 2 fuel it is necessary to be done to know the characteristic of geometry, condition and configuration of pin cell in the fuel assembly Because the geometry, configuration and condition of the pin cell in fuel core determine the loading strategy of in-core fuel management Calculation of k e ff is a part of the neutronic core parameter calculation to know the reactor physics characteristic. Generally, core calculation is done using computer code starts from modelling one unit fuel lattice cell, fuel assembly, reflector, irradiation facility and until core reactor. In this research, the modelling of pin cell and fuel assembly of the PWR 17 ×17 is done homogeneously. Calculation of the k-eff is done with variation of the fuel volume fraction, fuel pin diameter, fuel enrichment. The calculation is using by NITAWL and CENTRM, and then the results will be compared to KENOVI code. The result showed that the value of k e ff for pin cell and fuel assembly PWR 17 ×17 is not different significantly with homogenous and heterogenous models. The results for fuel volume fraction of 0.5; rod pitch 1.26 cm and fuel pin diameter of 9.6 mm is critical with burn up of 35,0 GWd/t. The modeling and calculation method accurately is needed to calculation the core physic parameter, but sometimes, it is needed along time to calculate one model. (author)

Methodology and results of investigations of physical parameters of high-temperature reactors

International Nuclear Information System (INIS)

Cherepnin, Yu.S.; Chertkov, Yu.B.

1995-01-01

A physical investigations of reactors of stand complexes Baikal-1 and IGR have been carrying out more 30 years. Measuring methods of the physical investigations were divided into 2 groups: 1) methods for measuring of reactivity effects; 2) methods for measuring relative and absolute values of neutron flux and power release. The physical investigations on the reactors IVG-1 and IGR were carryied out under following conditions: during physical starts-up of regular variants of reactor cores; during energy starts-up of the reactors; before beginning of new loop chanel tests of the reactors; during research hot starts-up of the reactors the physical parameters were controled. The most full and authentic information about studied reactor have been providing by physical investigations. In 1984 physical investigations were carryied out on the IGR reactor and then the hot start-up of the mostest power and mostest large on fuel loading loop chanel was carryied out. This chanel contained 6 fuel assemblies with the summary fuel loading 3,06 kilogrammes of uranium and it was calculated for power equal to 20 MW. In 1988 the physical investigations for selection of project process chanels destined for new water cooled reactor core were carryied out. In 1993 the neutron-physical calculation on possibility of tests for the rector Nerva fuel element was carryied out. 9 refs., 4 figs

OKLO: Fossil nuclear reactors. Physical study

International Nuclear Information System (INIS)

Naudet, R.

1991-04-01

This book presents a study of Oklo reactors, based essentially on physics and particularly neutronics but reviewing also all what is known on this topic, regrouping observations, measurement results and interpretative calculations. A remarkable characteristic of the study is the use of sophisticated reactor calculation methods for analysis of what happened two billion years ago in a uranium deposit. 200 refs [fr

Physical Characteristics of the Dalat Nuclear Research Reactor

International Nuclear Information System (INIS)

Ngo Quang Huy

1994-10-01

The operation of the TRIGA MARK II reactor of nominal power 250 KW has been stopped as all the fuel elements have been dismounted and taken away in 1968. The reconstruction of the reactor was accomplished with Russian technological assistance after 1975. The nominal power of the reconstructed reactor is of 500 KW. The recent Dalat reactor is unique of its kind in the world: Russian-designed core combined with left-over infrastructure of the American-made TRIGA II. The reactor was loaded in November 1983. It has reached physical criticality on 1/11/1983 (without central neutron trap) and on 18/12/1983 (with central neutron trap). The power start up occurred in February 1984 and from 20/3/1984 the reactor began to be operated at the nominal power 500 KW. The selected reports included in the proceedings reflect the start up procedures and numerous results obtained in the Dalat Nuclear Research Institute and the Centre of Nuclear Techniques on the determination of different physical characteristics of the reactor. These characteristics are of the first importance for the safe operation of the Dalat reactor

Application of autoregressive moving average model in reactor noise analysis

International Nuclear Information System (INIS)

Tran Dinh Tri

1993-01-01

The application of an autoregressive (AR) model to estimating noise measurements has achieved many successes in reactor noise analysis in the last ten years. The physical processes that take place in the nuclear reactor, however, are described by an autoregressive moving average (ARMA) model rather than by an AR model. Consequently more correct results could be obtained by applying the ARMA model instead of the AR model to reactor noise analysis. In this paper the system of the generalised Yule-Walker equations is derived from the equation of an ARMA model, then a method for its solution is given. Numerical results show the applications of the method proposed. (author)

Activity report of Reactor Physics Division : 1990

International Nuclear Information System (INIS)

Mohanakrishnan, P.

1991-01-01

The major Research and Development and Project activities carried out during the year 1990 in Reactor Physics Division are presented in the form of summaries in this report. The various activities are organised under the following areas : (1) Nuclear Data Evaluation, Processing and Validation, (2) Core Physics and Analysis, (3) Reactor Kinetics and Safety Analysis, (4) Noise Analysis, and (5) Radiation Transport and Shielding. FBTR was restarted in July 1990 and the power was raised upto 500 kW. A number of low power physics experiments on reactivity coefficients, kinetics and noise, neutron flux and gamma dose in B cells, were performed, which are discussed in this report. (author). figs., tabs

High-resolution coupled physics solvers for analysing fine-scale nuclear reactor design problems

Science.gov (United States)

Mahadevan, Vijay S.; Merzari, Elia; Tautges, Timothy; Jain, Rajeev; Obabko, Aleksandr; Smith, Michael; Fischer, Paul

2014-01-01

An integrated multi-physics simulation capability for the design and analysis of current and future nuclear reactor models is being investigated, to tightly couple neutron transport and thermal-hydraulics physics under the SHARP framework. Over several years, high-fidelity, validated mono-physics solvers with proven scalability on petascale architectures have been developed independently. Based on a unified component-based architecture, these existing codes can be coupled with a mesh-data backplane and a flexible coupling-strategy-based driver suite to produce a viable tool for analysts. The goal of the SHARP framework is to perform fully resolved coupled physics analysis of a reactor on heterogeneous geometry, in order to reduce the overall numerical uncertainty while leveraging available computational resources. The coupling methodology and software interfaces of the framework are presented, along with verification studies on two representative fast sodium-cooled reactor demonstration problems to prove the usability of the SHARP framework. PMID:24982250

Development of modeling tools for pin-by-pin precise reactor simulation

International Nuclear Information System (INIS)

Ma Yan; Li Shu; Li Gang; Zhang Baoyin; Deng Li; Fu Yuanguang

2013-01-01

In order to develop large-scale transport simulation and calculation method (such as simulation of whole reactor core pin-by-pin problem), the Institute of Applied Physics and Computational Mathematics developed the neutron-photon coupled transport code JMCT and the toolkit JCOGIN. Creating physical calculation model easily and efficiently can essentially reduce problem solving time. Currently, lots of visual modeling programs have been developed based on different CAD systems. In this article, the developing idea of a visual modeling tool based on field oriented development was introduced. Considering the feature of physical modeling, fast and convenient operation modules were developed. In order to solve the storage and conversion problems of large scale models, the data structure and conversional algorithm based on the hierarchical geometry tree were designed. The automatic conversion and generation of physical model input file for JMCT were realized. By using this modeling tool, the Dayawan reactor whole core physical model was created, and the transformed file was delivered to JMCT for transport calculation. The results validate the correctness of the visual modeling tool. (authors)

Proceedings on the Second Autumn School on Reactor Physics EROEFI II

Energy Technology Data Exchange (ETDEWEB)

Racz, A [ed.

1996-12-31

The main topics of the Reactor Physics School were neutron and reactor physical calculations, reactor safety, systems theory, simulation of accidents, reactor monitoring system, computer codes and procedures for solving specific problems in the field of nuclear reactors (especially safety). A special attention was paid to the AGNES project. Papers falling in the INIS scope have been abstracted and indexed individually for the INIS database. (K.A.).

Proceedings on the Second Autumn School on Reactor Physics EROEFI II

International Nuclear Information System (INIS)

Racz, A.

1995-01-01

The main topics of the Reactor Physics School were neutron and reactor physical calculations, reactor safety, systems theory, simulation of accidents, reactor monitoring system, computer codes and procedures for solving specific problems in the field of nuclear reactors (especially safety). A special attention was paid to the AGNES project. Papers falling in the INIS scope have been abstracted and indexed individually for the INIS database. (K.A.)

Micro-Reactor Physics of MOX-Fueled Core

International Nuclear Information System (INIS)

Takeda, T.

2001-01-01

Recently, fuel assemblies of light water reactors have become complicated because of the extension of fuel burnup and the use of high-enriched Gd and mixed-oxide (MOX) fuel, etc. In conventional assembly calculations, the detailed flux distribution, spectrum distribution, and space dependence of self-shielding within a fuel pellet are not directly taken into account. The experimental and theoretical study of investigating these microscopic properties is named micro-reactor physics. The purpose of this work is to show the importance of micro-reactor physics in the analysis of MOX fuel assemblies. Several authors have done related studies; however, their studies are limited to fuel pin cells, and they are never mentioned with regard to burnup effect, which is important for actual core design

Activity report of Reactor Physics Division - 1989

International Nuclear Information System (INIS)

1990-01-01

The highlights of the various studies carried out during the year 1989 in Reactor Physics Division are presented in this report in the form of summaries. The topics are organised under the following subjects: (1) nuclear data evaluation, processing and validation, (2) core physics and analysis, (3) reacto r kinetics and safety analysis, (4) noise analysis, and radiation transport and shielding. It is observed that with the restart and operation of FBTR at low power for some time, some of the low power physics experiments were completed and plans and procedures for the remaining physics experiments at intermediate and high power (upto 10 MWt) have been prepared. The lists of publications by the members of Division and the Reactor Physics Seminars held during the year 19 89, are included at the end of the report. (author). refs., figs., tabs

Validation of Reactor Physics-Thermal hydraulics Calculations for Research Reactors Cooled by the Laminar Flow of Water

Energy Technology Data Exchange (ETDEWEB)

Jordan, K. A.; Schubring, D. [Univ. of Florida, Florida (United States); Girardin, G.; Pautz, A. [Swiss Federal Institute of Technology, Zuerich (Switzerland)

2013-07-01

A collaboration between the University of Florida and the Swiss Federal Institute of Technology, Lausanne (EPFL) has been formed to develop and validate detailed coupled multiphysics models of the zero-power (100 W) CROCUS reactor at EPFL and the 100 kW University of Florida Training Reactor, for the comprehensive analysis of the reactor behavior under transient (neutronic or thermal-hydraulic induced) conditions. These two reactors differ significantly in the core design and thermal power output, but share unique heat transfer and flow characteristics. They are characterized by single-phase laminar water flow at near-atmospheric pressures in complex geometries with the possibility of mechanically entrained air bubbles. Validation experiments will be designed to expand the validation domain of these existing models, computational codes and techniques. In this process, emphasis will be placed on validation of the coupled models developed to gain confidence in their applicability for safety analysis. EPFL is responsible for the design and implementation of transient experiments to generate a database of reactor parameters (flow distribution, power profile, and power evolution) to be used to validate against code predictions. The transient experiments performed at EPFL will be simulated on the basis of developed models for these tasks. Comparative analysis will be performed with SERPENT and MCNPX reference core models. UF focuses on the generation of the coupled neutron kinetics and thermal-hydraulic models, including implementation of a TRACE/PARCS reactor simulator model, a PARET model, and development of full-field computational fluid dynamics models (using OpenFOAM) for refined thermal-hydraulics physics treatments. In this subtask of the project, the aim is to verify by means of CFD the validity of TRACE predictions for near-atmospheric pressure water flow in the presence of mechanically entrained air bubbles. The scientific understanding of these multiphysics

Validation of Reactor Physics-Thermal hydraulics Calculations for Research Reactors Cooled by the Laminar Flow of Water

International Nuclear Information System (INIS)

Jordan, K. A.; Schubring, D.; Girardin, G.; Pautz, A.

2013-01-01

A collaboration between the University of Florida and the Swiss Federal Institute of Technology, Lausanne (EPFL) has been formed to develop and validate detailed coupled multiphysics models of the zero-power (100 W) CROCUS reactor at EPFL and the 100 kW University of Florida Training Reactor, for the comprehensive analysis of the reactor behavior under transient (neutronic or thermal-hydraulic induced) conditions. These two reactors differ significantly in the core design and thermal power output, but share unique heat transfer and flow characteristics. They are characterized by single-phase laminar water flow at near-atmospheric pressures in complex geometries with the possibility of mechanically entrained air bubbles. Validation experiments will be designed to expand the validation domain of these existing models, computational codes and techniques. In this process, emphasis will be placed on validation of the coupled models developed to gain confidence in their applicability for safety analysis. EPFL is responsible for the design and implementation of transient experiments to generate a database of reactor parameters (flow distribution, power profile, and power evolution) to be used to validate against code predictions. The transient experiments performed at EPFL will be simulated on the basis of developed models for these tasks. Comparative analysis will be performed with SERPENT and MCNPX reference core models. UF focuses on the generation of the coupled neutron kinetics and thermal-hydraulic models, including implementation of a TRACE/PARCS reactor simulator model, a PARET model, and development of full-field computational fluid dynamics models (using OpenFOAM) for refined thermal-hydraulics physics treatments. In this subtask of the project, the aim is to verify by means of CFD the validity of TRACE predictions for near-atmospheric pressure water flow in the presence of mechanically entrained air bubbles. The scientific understanding of these multiphysics

Progress report on reactor physics research program, January 1963 - February 1964

Energy Technology Data Exchange (ETDEWEB)

NONE

1964-02-15

This progress report is a part of the annual report of the department of reactor physics prepared for the Boris Kidric Institute of nuclear sciences. It is a review of research activities in the field of theoretical and experimental reactor physics in the year 1973. A part of this program was included in the NPY Cooperative program in reactor physics. The topics covered by this report are as follows: Calculations of the thermal neutron distribution and reaction rate in a reactor cell and comparison with experiments; buckling measurements; thermalization and slowing down of neutrons; pulsed neutron source techniques; and reactor kinetics.

Progress report on reactor physics research program, January 1963 - February 1964

International Nuclear Information System (INIS)

1964-02-01

This progress report is a part of the annual report of the department of reactor physics prepared for the Boris Kidric Institute of nuclear sciences. It is a review of research activities in the field of theoretical and experimental reactor physics in the year 1973. A part of this program was included in the NPY Cooperative program in reactor physics. The topics covered by this report are as follows: Calculations of the thermal neutron distribution and reaction rate in a reactor cell and comparison with experiments; buckling measurements; thermalization and slowing down of neutrons; pulsed neutron source techniques; and reactor kinetics

A Multi-Physics simulation of the Reactor Core using CUPID/MASTER

International Nuclear Information System (INIS)

Lee, Jae Ryong; Cho, Hyoung Kyu; Yoon, Han Young; Cho, Jin Young; Jeong, Jae Jun

2011-01-01

KAERI has been developing a component-scale thermal hydraulics code, CUPID. The aim of the code is for multi-dimensional, multi-physics and multi-scale thermal hydraulics analysis. In our previous papers, the CUPID code has proved to be able to reproduce multidimensional thermal hydraulic analysis by validated with various conceptual problems and experimental data. For the numerical closure, it adopts a three dimensional, transient, two-phase and three-field model, and includes physical models and correlations of the interfacial mass, momentum, and energy transfer. For the multi-scale analysis, the CUPID is on progress to merge into system-scale thermal hydraulic code, MARS. In the present paper, a multi-physics simulation was performed by coupling the CUPID with three dimensional neutron kinetics code, MASTER. The MASTER is merged into the CUPID as a dynamic link library (DLL). The APR1400 reactor core during control rod drop/ejection accident was simulated as an example by adopting a porous media approach to employ fuel assembly. The following sections present the numerical modeling for the reactor core, coupling of the kinetics code, and the simulation results

Reactor physics innovations of the advanced CANDU reactor core: adaptable and efficient

International Nuclear Information System (INIS)

Chan, P.S.W.; Hopwood, J.M.; Bonechi, M.

2003-01-01

The Advanced CANDU Reactor (ACR) is designed to have a benign, operator-friendly core physics characteristic, including a slightly negative coolant-void reactivity and a moderately negative power coefficient. The discharge fuel burnup is about three times that of natural uranium fuel in current CANDU reactors. Key features of the reactor physics innovations in the ACR core include the use of H 2 O coolant, slightly enriched uranium (SEU) fuel, and D 2 O moderator in a reduced lattice pitch. These innovations result in substantial improvements in economics, as well as significant enhancements in reactor performance and waste reduction over the current reactor design. The ACR can be readily adapted to different power outputs by increasing or decreasing the number of fuel channels, while maintaining identical fuel and fuel-channel characteristics. The flexibility provided by on-power refuelling and simple fuel bundle design enables the ACR to easily adapt to the use of plutonium and thorium fuel cycles. No major modifications to the basic ACR design are required because the benign neutronic characteristics of the SEU fuel cycle are also inherent in these advanced fuel cycles. (author)

Annual progress report for 1982 of Theoretical Reactor Physics Section

International Nuclear Information System (INIS)

Rastogi, B.P.; Kumar, Vinod

1983-01-01

The progress of work done in the Theoretical Reactor Physics Section of the Bhabha Atomic Research Centre, Bombay, during the calendar year 1982 is reported in the form of write-ups and summaries. The main thrust of the work has been to master the neutronic design technology of four different types of nuclear reactor types, namely, pressurized heavy water reactors, boiling light water reactors, pressurized light water reactors and fast breeder reactors. The development work for the neutronic analysis, fuel design, and fuel management of the BWR type reactors of the Tarapur Atomic Power Station has been completed. A new reactor simulator system for PHWR design analysis and core follow-up was completed. Three dimensional static analysis codes based on nodal and finite element methods for the design work of larger size (500-750 MWe) reactors have been developed. Space link kinetics codes in one, two and three dimensions for above-mentioned reactor systems have been written and validated. Fast reactor core disruptive analysis codes have been developed. In the course of R and D work concerning various types of reactor projects, investigations were also carried in the allied areas of Monte Carlo techniques, integral transform methods, path integral methods, high spin states in heavy nuclei and a hydrodynamics model for a laser driven fusion system. (M.G.B.)

Nuclear data and reactor physics activities in Indonesia

Energy Technology Data Exchange (ETDEWEB)

Liem, P.H. [National Atomic Energy Agency, Tangerang (Indonesia). Center for Multipurpose Reactor

1998-03-01

The nuclear data and reactor physics activities in Indonesia, especially, in the National Atomic Energy Agency are presented. In the nuclear data field, the Agency is now taking the position of a user of the main nuclear data libraries such as JENDL and ENDF/B. These nuclear data libraries become the main sources for producing problem dependent cross section sets that are needed by cell calculation codes or transport codes for design, analysis and safety evaluation of research reactors. In the reactor physics field, besides utilising the existing core analysis codes obtained from bilateral and international co-operation, the Agency is putting much effort to self-develop Batan`s codes for reactor physics calculations, in particular, for research reactor and high temperature reactor design, analysis and fuel management. Under the collaboration with JAERI, Monte Carlo criticality calculations on the first criticality of RSG GAS (MPR-30) first core were done using JAERI continuous energy, vectorized Monte Carlo code, MVP, with JENDL-3.1 and JENDL-3.2 nuclear data libraries. The results were then compared with the experiment data collected during the commissioning phase. Monte Carlo calculations with both JENDL-3.1 and -3.2 libraries produced k{sub eff} values with excellent agreement with experiment data, however, systematically, JENDL-3.2 library showed slightly higher k{sub eff} values than JENDL-3.1 library. (author)

The past, present, and future of test and research reactor physics

International Nuclear Information System (INIS)

Ryskamp, J.M.

1992-01-01

Reactor physics calculations have been performed on research reactors since the first one was built 50 yr ago under the University of Chicago stadium. Since then, reactor physics calculations have evolved from Fermi-age theory calculations performed with slide rules to three-dimensional, continuous-energy, coupled neutron-photon Monte Carlo computations performed with supercomputers and workstations. Such enormous progress in reactor physics leads us to believe that the next 50 year will be just as exciting. This paper reviews this transition from the past to the future

Communication and computer technologies for teaching physics in nuclear reactors

International Nuclear Information System (INIS)

Murua, C; Chautemps, A; Odetto, J; Keil, W; Trivino, S; Rossi, F; Perez Lucero, A

2012-01-01

In order to train personnel inn order to train personnel in Embalse Nuclear Power Plant, and provided that such training given primarily on the location of such a facility, we designed a pedagogical strategy that combined the use of conventional resources with new information technologies. Since the Nuclear Reactor RA-0 is an ideal tool for teaching Reactor Physics, priority was the use of it, both locally remotely. The teaching strategy is based on four pillar: -Lectures on the Power Plant (using a virtual classroom to support); -Remote monitoring of Ra-0 Nuclear Reactor parameters while operating (RA0REMOTO); -Use, through the Internet, of the Ra-0 Nuclear Reactor Simulator (RA0SIMUL); -Made in the Nuclear Reactor RA-0 of Reactor Physics practical. The work emphasizes RA0REMOTO and RA0SIMUL systems. The RA0REMOTO system is an appendix of the Electronic Data Acquisition System (SEAD) of the Nuclear Reactor RA-0. This system acquires signals from Reactor instrumentation and sends them to a server running the software that 'publish' the reactor parameters on the internet. Students may, during the lectures, monitor any parameter of the reactor while it operates, which allows teachers to compare theory with reality. RA0SIMUL is a simulator on the RA-0, which allows students to 'operate' a reactor analyzing the underlying physics concepts (author)

Statistic method of research reactors maximum permissible power calculation

International Nuclear Information System (INIS)

Grosheva, N.A.; Kirsanov, G.A.; Konoplev, K.A.; Chmshkyan, D.V.

1998-01-01

The technique for calculating maximum permissible power of a research reactor at which the probability of the thermal-process accident does not exceed the specified value, is presented. The statistical method is used for the calculations. It is regarded that the determining function related to the reactor safety is the known function of the reactor power and many statistically independent values which list includes the reactor process parameters, geometrical characteristics of the reactor core and fuel elements, as well as random factors connected with the reactor specific features. Heat flux density or temperature is taken as a limiting factor. The program realization of the method discussed is briefly described. The results of calculating the PIK reactor margin coefficients for different probabilities of the thermal-process accident are considered as an example. It is shown that the probability of an accident with fuel element melting in hot zone is lower than 10 -8 1 per year for the reactor rated power [ru

General remarks on fast neutron reactor physics

International Nuclear Information System (INIS)

Barre, J.Y.

1980-01-01

The main aspects of fast reactor physics, presented in these lecture notes, are restricted to LMFBR's. The emphasis is placed on the core neutronic balance and the burn-up problems. After a brief description of the power reactor main components and of the fast reactor chronology, the fundamental parameters of the one-group neutronic balance are briefly reviewed. Then the neutronic burn-up problems related to the Pu production and to the doubling time are considered

Genome Analysis of Latin American Cervical Cancer: Frequent Activation of the PIK3CA Pathway.

Science.gov (United States)

Lou, Hong; Villagran, Guillermo; Boland, Joseph F; Im, Kate M; Polo, Sarita; Zhou, Weiyin; Odey, Ushie; Juárez-Torres, Eligia; Medina-Martínez, Ingrid; Roman-Basaure, Edgar; Mitchell, Jason; Roberson, David; Sawitzke, Julie; Garland, Lisa; Rodríguez-Herrera, Maria; Wells, David; Troyer, Jennifer; Pinto, Francisco Castillo; Bass, Sara; Zhang, Xijun; Castillo, Miriam; Gold, Bert; Morales, Hesler; Yeager, Meredith; Berumen, Jaime; Alvirez, Enrique; Gharzouzi, Eduardo; Dean, Michael

2015-12-01

Cervical cancer is one of the most common causes of cancer mortality for women living in poverty, causing more than 28,000 deaths annually in Latin America and 266,000 worldwide. To better understand the molecular basis of the disease, we ascertained blood and tumor samples from Guatemala and Venezuela and performed genomic characterization. We performed human papillomavirus (HPV) typing and identified somatically mutated genes using exome and ultra-deep targeted sequencing with confirmation in samples from Mexico. Copy number changes were also assessed in the exome sequence. Cervical cancer cases in Guatemala and Venezuela have an average age of diagnosis of 50 years and 5.6 children. Analysis of 675 tumors revealed activation of PIK3CA and other PI3K/AKT pathway genes in 31% of squamous carcinomas and 24% of adeno- and adenosquamous tumors, predominantly at two sites (E542K, E545K) in the helical domain of the PIK3CA gene. This distribution of PIK3CA mutations is distinct from most other cancer types and does not result in the in vitro phosphorylation of AKT. Somatic mutations were more frequent in squamous carcinomas diagnosed after the age of 50 years. Frequent gain of chromosome 3q was found, and low PIK3CA mutation fractions in many tumors suggest that PI3K mutation can be a late event in tumor progression. PI3K pathway mutation is important to cervical carcinogenesis in Latin America. Therapeutic agents that directly target PI3K could play a role in the therapy of this common malignancy. ©2015 American Association for Cancer Research.

Three-dimensional reactor model for the Paks NPP full-scope simulator

International Nuclear Information System (INIS)

Gyori, C.; Hegyi, G.; Hozer, Z.; Kereszturi, A.; Maraczy, C.

1993-01-01

The reactor model includes thermohydraulic and neutron-physical components. The thermohydraulic model is based on the SMABRE code developed at the Technical Research Centre of Finland for the analysis of loss-of-coolant transients in PWRs. The fuel rod model will be replaced by a new software module providing a comprehensive description of the behavior of fuel rods during reactor transients and hypothetical accidents. The calculation is performed in four individual models: fuel rod temperature model, fuel rod internal pressure model, fuel rod deformation model and fuel rod failure model. In the neutron-physical model the core is calculated with nodes for all of the 349 fuel assemblies, and each assembly is calculated in ten layers. (Z.S.) 1 fig., 5 refs

Conceptual research on reactor core physics for accelerator driven sub-critical reactor

International Nuclear Information System (INIS)

Zhao Zhixiang; Ding Dazhao; Liu Guisheng; Fan Sheng; Shen Qingbiao; Zhang Baocheng; Tian Ye

2000-01-01

The main properties of reactor core physics are analysed for accelerator driven sub-critical reactor. These properties include the breeding of fission nuclides, the condition of equilibrium, the accumulation of long-lived radioactive wastes, the effect from poison of fission products, as well as the thermal power output and the energy gain for sub-critical reactor. The comparison between thermal and fast system for main properties are carried out. The properties for a thermal-fast coupled system are also analysed

Boiling water reactor modeling capabilities of MMS-02

International Nuclear Information System (INIS)

May, R.S.; Abdollahian, D.A.; Elias, E.; Shak, D.P.

1987-01-01

During the development period for the Modular Modeling System (MMS) library modules, the Boiling Water Reactor (BWR) has been the last major component to be addressed. The BWRX module includes models of the reactor core, reactor vessel, and recirculation loop. A pre-release version was made available for utility use in September 1983. Since that time a number of changes have been incorporated in BWRX to (1) improve running time for most transient events of interest, (2) extend its capability to include certain events of interest in reactor safety analysis, and (3) incorporate a variety of improvements to the module interfaces and user input formats. The purposes of this study were to briefly review the module structure and physical models, to point the differences between the MMS-02 BWRX module and the BWRX version previously available in the TESTREV1 library, to provide guidelines for choosing among the various user options, and to present some representative results

Proceedings of the 1992 topical meeting on advances in reactor physics

International Nuclear Information System (INIS)

1992-01-01

This document, Volume 2, presents proceedings of the 1992 Topical Meeting on Advances in Reactor Physics on March 8--11, 1992 at Charleston, SC. Session topics were as follows: Transport Theory; Fast Reactors; Plant Analyzers; Integral Experiments/Measurements ampersand Analysis; Core Computational Systems; Reactor Physics; Monte Carlo; Safety Aspects of Heavy Water Reactors; and Space-Time Core Kinetics. The individual reports have been cataloged separately. (FI)

Studies on reactor physics

International Nuclear Information System (INIS)

1960-01-01

Most of the peaceful applications of atomic energy are inherently dependent on advances in the science and technology of nuclear reactors, and aspects of this development are part of a major programme of the International Atomic Energy Agency. The most useful role that the Agency can play is as a co-ordinating body or central forum where the trends can be reviewed and the results assessed. Some of the basic studies are carried out by members of the Agency's own scientific staff. The Agency also convenes groups of experts from different countries to examine a particular problem in detail and make any necessary recommendations. Some of the important subjects are discussed at international scientific meetings held by the Agency. One of the subjects covered by such studies is the physics of nuclear reactors and a specific topic recently discussed was Codes for Reactor Computations, on which a seminar was held in Vienna in April this year. Another The members of the Panel described the development of heavy water reactors, the equipment and methods of research currently used, and plans for further development in their respective countries meeting of Panel of Experts on Heavy Water Lattices was held in Vienna in August 1959

International Reactor Physics Experiment Evaluation (IRPhE) Project. IRPhE Handbook - 2015 edition

International Nuclear Information System (INIS)

Bess, John D.; Gullifor, Jim

2015-03-01

The purpose of the International Reactor Physics Experiment Evaluation (IRPhE) Project is to provide an extensively peer-reviewed set of reactor physics-related integral data that can be used by reactor designers and safety analysts to validate the analytical tools used to design next-generation reactors and establish the safety basis for operation of these reactors. This work of the IRPhE Project is formally documented in the 'International Handbook of Evaluated Reactor Physics Benchmark Experiments', a single source of verified and extensively peer-reviewed reactor physics benchmark measurements data. The evaluation process entails the following steps: Identify a comprehensive set of reactor physics experimental measurements data, Evaluate the data and quantify overall uncertainties through various types of sensitivity analysis to the extent possible, verify the data by reviewing original and subsequently revised documentation, and by talking with the experimenters or individuals who are familiar with the experimental facility, Compile the data into a standardized format, Perform calculations of each experiment with standard reactor physics codes where it would add information, Formally document the work into a single source of verified and peer reviewed reactor physics benchmark measurements data. The International Handbook of Evaluated Reactor Physics Benchmark Experiments contains reactor physics benchmark specifications that have been derived from experiments that were performed at nuclear facilities around the world. The benchmark specifications are intended for use by reactor designers, safety analysts and nuclear data evaluators to validate calculation techniques and data. Example calculations are presented; these do not constitute a validation or endorsement of the codes or cross-section data. The 2015 edition of the International Handbook of Evaluated Reactor Physics Benchmark Experiments contains data from 143 experimental series that were

Reactor noise diagnostics based on multivariate autoregressive modeling: Application to LOFT [Loss-of-Fluid-Test] reactor process noise

International Nuclear Information System (INIS)

Gloeckler, O.; Upadhyaya, B.R.

1987-01-01

Multivariate noise analysis of power reactor operating signals is useful for plant diagnostics, for isolating process and sensor anomalies, and for automated plant monitoring. In order to develop a reliable procedure, the previously established techniques for empirical modeling of fluctuation signals in power reactors have been improved. Application of the complete algorithm to operational data from the Loss-of-Fluid-Test (LOFT) Reactor showed that earlier conjectures (based on physical modeling) regarding the perturbation sources in a Pressurized Water Reactor (PWR) affecting coolant temperature and neutron power fluctuations can be systematically explained. This advanced methodology has important implication regarding plant diagnostics, and system or sensor anomaly isolation. 6 refs., 24 figs

Modeling irradiation embrittlement in reactor pressure vessel steels

International Nuclear Information System (INIS)

Odette, G.R.

1998-01-01

As a result of the popularity of the Agencies report 'Neutron Irradiation Embrittlement of Reactor Pressure Vessel Steels' of 1975, it was decided that another report on this broad subject would be of use. In this report, background and contemporary views on specially identified areas of the subject are considered as self-contained chapters, written by experts. In chapter 10, numerical modeling of irradiation embrittlement in reactor vessel steels are introduced. Physically-based models are developed and their role in advancing the state-of-the-art of predicting irradiation embrittlement of RPV steels is stressed

Investigation of the basic reactor physics characteristics of the Dalat Nuclear Research Reactor

Energy Technology Data Exchange (ETDEWEB)

Huy, Ngo Quang [Centre for Nuclear Technique Application, Ho Chi Minh City (Viet Nam); Thong, Ha Van; Khang, Ngo Phu [Nuclear Research Inst., Da Lat (Viet Nam)

1994-10-01

The Dalat nuclear research reactor was reconstructed from TRIGA MARK II reactor, built in 1963 with nominal power of 250 KW, and reached its planned nominal power of 500 kW for the first time in Feb. 1984. The Dalat reactor has some characteristics distinct from the former TRIGA reactor. Investigation of its characteristics is carried out by the determination of the reactor physics parameters. This paper represents the experimental results obtained for the effective fraction of the delayed photoneutrons, the extraneous neutron source left after the reactor is shut down, the lowest power levels of reactor critical states, the relative axial and radial distributions of thermal neutrons, the safe positive reactivity inserted into the reactor at deep subcritical state, the reactivity temperature coefficient of water, the temperature on the surface of the fuel elements, etc. (author). 10 refs., 10 figs., 2 tabs.

HTR characteristics affecting reactor physics

International Nuclear Information System (INIS)

Ehlers, K.

1980-01-01

A physical description of high-temperature has-cooled reactors is given, followed by an overview of HTR characteristics. The emphasis is placed on the HTR fuel cycle alternatives and thermohydraulics of pebble bed core. Some prospects of HTRs in the Federal Republic of Germany are also presented

Research on acceleration method of reactor physics based on FPGA platforms

International Nuclear Information System (INIS)

Li, C.; Yu, G.; Wang, K.

2013-01-01

The physical designs of the new concept reactors which have complex structure, various materials and neutronic energy spectrum, have greatly improved the requirements to the calculation methods and the corresponding computing hardware. Along with the widely used parallel algorithm, heterogeneous platforms architecture has been introduced into numerical computations in reactor physics. Because of the natural parallel characteristics, the CPU-FPGA architecture is often used to accelerate numerical computation. This paper studies the application and features of this kind of heterogeneous platforms used in numerical calculation of reactor physics through practical examples. After the designed neutron diffusion module based on CPU-FPGA architecture achieves a 11.2 speed up factor, it is proved to be feasible to apply this kind of heterogeneous platform into reactor physics. (authors)

Validation study of the reactor physics lattice transport code WIMSD-5B by TRX and BAPL critical experiments of light water reactors

International Nuclear Information System (INIS)

Khan, M.J.H.; Alam, A.B.M.K.; Ahsan, M.H.; Mamun, K.A.A.; Islam, S.M.A.

2015-01-01

Highlights: • To validate the reactor physics lattice code WIMSD-5B by this analysis. • To model TRX and BAPL critical experiments using WIMSD-5B. • To compare the calculated results with experiment and MCNP results. • To rely on WIMSD-5B code for TRIGA calculations. - Abstract: The aim of this analysis is to validate the reactor physics lattice transport code WIMSD-5B by TRX (thermal reactor-one region lattice) and BAPL (Bettis Atomic Power Laboratory-one region lattice) critical experiments of light water reactors for neutronics analysis of 3 MW TRIGA Mark-II research reactor at AERE, Dhaka, Bangladesh. This analysis is achieved through the analysis of integral parameters of five light water reactor critical experiments TRX-1, TRX-2, BAPL-UO 2 -1, BAPL-UO 2 -2 and BAPL-UO 2 -3 based on evaluated nuclear data libraries JEFF-3.1 and ENDF/B-VII.1. In integral measurements, these experiments are considered as standard benchmark lattices for validating the reactor physics lattice transport code WIMSD-5B as well as evaluated nuclear data libraries. The integral parameters of the said critical experiments are calculated using the reactor physics lattice transport code WIMSD-5B. The calculated integral parameters are compared to the measured values as well as the earlier published MCNP results based on the Chinese evaluated nuclear data library CENDL-3.0 for assessment of deterministic calculation. It was found that the calculated integral parameters give mostly reasonable and globally consistent results with the experiment and the MCNP results. Besides, the group constants in WIMS format for the isotopes U-235 and U-238 between two data files have been compared using WIMS library utility code WILLIE and it was found that the group constants are well consistent with each other. Therefore, this analysis reveals the validation study of the reactor physics lattice transport code WIMSD-5B based on JEFF-3.1 and ENDF/B-VII.1 libraries and can also be essential to

Numerical Modelling of Wood Gasification in Thermal Plasma Reactor

Czech Academy of Sciences Publication Activity Database

Hirka, Ivan; Živný, Oldřich; Hrabovský, Milan

2017-01-01

Roč. 37, č. 4 (2017), s. 947-965 ISSN 0272-4324 Institutional support: RVO:61389021 Keywords : Plasma modelling * CFD * Thermal plasma reactor * Biomass * Gasification * Syngas Subject RIV: BL - Plasma and Gas Discharge Physics OBOR OECD: Fluids and plasma physics (including surface physics) Impact factor: 2.355, year: 2016 https://link.springer.com/article/10.1007/s11090-017-9812-z

Reactor physics calculations in the Nordic countries

International Nuclear Information System (INIS)

Hoeglund, R.

1995-01-01

The seventh biennial meeting on reactor physics calculations in the Nordic countries was arranged by VTT Energy on May 8-9, 1995. 26 papers on different subjects in the field of reactor physics were presented by 45 participants representing research establishments, technical universities, utilities, consultants and suppliers. Resent development and verification of the program systems of ABB Atom, Risoe, Scandpower, Studsvik and VTT Energy were the main topic of the meeting. Benchmarking of the two assembly codes CASMO-4 and HELIOS is proceeding. Cross section data calculated with CASMO-HEX have been validated for the Loviisa reactors. On core analysis ABB atom gives a description on its latest core simulator version POLCA7 with the calculation Core Master 2 and the BWR core supervision system Core Watch. Transient calculations with HEXTRAN, HEXTRAN- PLIM, TRAB, RAMONA, SIMULATE-3K and a code based on PRESTO II/POLCA7 were also presented

Dual HER2\\PIK3CA targeting overcomes single-agent acquired resistance in HER2 amplified uterine serous carcinoma cell lines in vitro and in vivo

Science.gov (United States)

Lopez, Salvatore; Cocco, Emiliano; Black, Jonathan; Bellone, Stefania; Bonazzoli, Elena; Predolini, Federica; Ferrari, Francesca; Schwab, Carlton L.; English, Diana P.; Ratner, Elena; Silasi, Dan-Arin; Azodi, Masoud; Schwartz, Peter E.; Terranova, Corrado; Angioli, Roberto; Santin, Alessandro D.

2015-01-01

HER2/neu gene amplification and PIK3CA driver mutations are common in uterine serous carcinoma (USC), and may represent ideal therapeutic targets against this aggressive variant of endometrial cancer. We examined the sensitivity to neratinib, taselisib and the combination of the two compounds in in vitro and in vivo experiments using PIK3CA mutated and PIK3CA-wild type HER2/neu amplified USC cell lines. Cell viability and cell cycle distribution were assessed using flow-cytometry assays. Downstream signaling was assessed by immunoblotting. Preclinical efficacy of single versus dual inhibition was evaluated in vivo using two USC-xenografts. We found both single agent neratinib and taselisib to be active but only transiently effective in controlling the in vivo growth of USC xenografts harboring HER2/neu gene amplification with or without oncogenic PIK3CA mutations. In contrast, the combination of the two inhibitors caused a stronger and long lasting growth inhibition in both USC xenografts when compared to single agent therapy. Combined targeting of HER2 and PIK3CA was associated with a significant and dose-dependent increase in the percentage of cells in the G0/G1 phase of the cell cycle and a dose-dependent decline in the phosphorylation of S6. Importantly, dual inhibition therapy initiated after tumor progression in single agent-treated mice was still remarkably effective at inducing tumor regression in both large PIK3CA or pan-ErbB inhibitor-resistant USC xenografts. Dual HER2/PIK3CA blockade may represent a novel therapeutic option for USC patients harboring tumors with HER2/neu gene amplification and mutated or wild type PIK3CA resistant to chemotherapy. PMID:26333383

Dual HER2/PIK3CA Targeting Overcomes Single-Agent Acquired Resistance in HER2-Amplified Uterine Serous Carcinoma Cell Lines In Vitro and In Vivo.

Science.gov (United States)

Lopez, Salvatore; Cocco, Emiliano; Black, Jonathan; Bellone, Stefania; Bonazzoli, Elena; Predolini, Federica; Ferrari, Francesca; Schwab, Carlton L; English, Diana P; Ratner, Elena; Silasi, Dan-Arin; Azodi, Masoud; Schwartz, Peter E; Terranova, Corrado; Angioli, Roberto; Santin, Alessandro D

2015-11-01

HER2/neu gene amplification and PIK3CA driver mutations are common in uterine serous carcinoma (USC) and may represent ideal therapeutic targets against this aggressive variant of endometrial cancer. We examined the sensitivity to neratinib, taselisib, and the combination of the two compounds in in vitro and in vivo experiments using PIK3CA-mutated and PIK3CA wild-type HER2/neu-amplified USC cell lines. Cell viability and cell-cycle distribution were assessed using flow-cytometry assays. Downstream signaling was assessed by immunoblotting. Preclinical efficacy of single versus dual inhibition was evaluated in vivo using two USC xenografts. We found both single-agent neratinib and taselisib to be active but only transiently effective in controlling the in vivo growth of USC xenografts harboring HER2/neu gene amplification with or without oncogenic PIK3CA mutations. In contrast, the combination of the two inhibitors caused a stronger and long-lasting growth inhibition in both USC xenografts when compared with single-agent therapy. Combined targeting of HER2 and PIK3CA was associated with a significant and dose-dependent increase in the percentage of cells in the G0-G1 phase of the cell cycle and a dose-dependent decline in the phosphorylation of S6. Importantly, dual inhibition therapy initiated after tumor progression in single-agent-treated mice was still remarkably effective at inducing tumor regression in both large PIK3CA and pan-ErbB inhibitor-resistant USC xenografts. Dual HER2/PIK3CA blockade may represent a novel therapeutic option for USC patients harboring tumors with HER2/neu gene amplification and mutated or wild-type PIK3CA resistant to chemotherapy. ©2015 American Association for Cancer Research.

Monte Carlo simulation of core physics parameters of the Syrian MNSR reactor

International Nuclear Information System (INIS)

Khattab, K.; Sulieman, I.

2011-01-01

A 3-D neutronic model for the Syrian Miniature Neutron Source Reactor (MNSR) was developed earlier to conduct the reactor neutronic analysis using the MCNP-4C code. The continuous energy neutron cross sections were evaluated from the ENDF/B-VI library. This model is used in this paper to calculate the following reactor core physics parameters: the clean cold core excess reactivity, calibration of the control rod and calculation its shut down margin, calibration of the top beryllium shim plate reflector, the axial neutron flux distributions in the inner and outer irradiation positions and calculations of the prompt neutron life time (ι p ) and the effective delayed neutron fraction ( β e ff). Good agreements are noticed between the calculated and the measured results. These agreements indicate that the established model is an accurate representation of Syrian MNSR core and will be used for other calculations in the future. (author)

Nuclear reactor safety: physics and engineering aspects

International Nuclear Information System (INIS)

Kinchin, G.H.

1982-01-01

In order to carry out the sort of probabilistic analysis referred to by Farmer (Contemp. Phys.; 22:349(1981)), it is necessary to have a good understanding of the processes involved in both normal and accident conditions in a nuclear reactor. Some of these processes, for a variety of different reactor systems, are considered in sections dealing with the neutron chain reaction, the removal of heat from the reactor, material problems, reliability of protective systems and a number of specific topics of particular interest from the point of view of physics or engineering. (author)

Impact of the 37M fuel design on reactor physics characteristics

International Nuclear Information System (INIS)

Perez, R.; Ta, P.

2013-01-01

For CANDU nuclear reactors, aging of the Heat Transport System (HTS) leads to, among other effects, a reduction on the Critical Heat Flux (CHF) and dryout margin. In an effort to mitigate the impact of aging of the HTS on safety margins, Bruce Power is introducing a design change to the standard 37-element fuel bundle known as the modified 37-element fuel bundle, or 37M for short. As part of the overall design change process it was necessary to assess the impact of the modified fuel bundle design on key reactor physics parameters. Quantification of this impact on lattice cell properties, core reactivity properties, etc., was reached through a series of calculations using state-of-the-art lattice and core physics models, and comparisons against results for the standard fuel bundle. (author)

Fast reactor fuel pin behaviour modelling in the UK

Energy Technology Data Exchange (ETDEWEB)

Matthews, J R [UKAEA, Harwell, Didcot, Oxon (United Kingdom); Hughes, H [Springfields Nuclear Power Development Laboratories, Springfields, Salwick, Preston (United Kingdom)

1979-12-01

Two fuel behaviour codes have been applied extensively to fast reactor problems; SLEUTH developed at Sprlngfields Nuclear Laboratory and FRUMP at A.E.R.E. Harwell. The SLEUTH fuel pin endurance code was originally developed to define a programme of power cycling and power ramp experiments In Advanced Gas Cooled Reactors (AGRs) where, because of the very soft cladding, pellet clad interaction is severe. The code was required to define accelerated test conditions to generalise from the observed endurance to that under other power histories and to select for investigation the most significant design, material and operational variables. The weak clad and low coolant pressure combine to make fission gas swelling a major contributor to clad deformation while the high clad ductility renders the distribution of strain readily observable. This has led to a detailed study of strain concentrations using the SEER code. SLEUTH and SEER have subsequently been used to specify power cycling and power ramp 112 experiments in water cooled, fast and materials testing reactors with the aim of developing a unified quantitative model of pellet-clad interaction whatever the reactor system. The FRUMP fuel behaviour code was developed specifically for the interpretation of fast reactor fuel pin behaviour. Experience with earlier models was valuable In its development. Originally the model was developed to describe behaviour during normal operation, but subsequently the code has been used extensively in the field of accident studies. Much of the effort in FRUMP development has been devoted to the production of physical models of the various effects of irradiation and the temperature gradients on the structure of the fuel and clad. Each process is modelled as well as is permitted by current knowledge and the limitations of computing costs. Each sub-model has a form which reflects the underlying mechanisms, where quantities are unknown values are assigned semi-empirically, i.e. coefficients

Fast reactor fuel pin behaviour modelling in the UK

International Nuclear Information System (INIS)

Matthews, J.R.; Hughes, H.

1979-01-01

Two fuel behaviour codes have been applied extensively to fast reactor problems; SLEUTH developed at Sprlngfields Nuclear Laboratory and FRUMP at A.E.R.E. Harwell. The SLEUTH fuel pin endurance code was originally developed to define a programme of power cycling and power ramp experiments In Advanced Gas Cooled Reactors (AGRs) where, because of the very soft cladding, pellet clad interaction is severe. The code was required to define accelerated test conditions to generalise from the observed endurance to that under other power histories and to select for investigation the most significant design, material and operational variables. The weak clad and low coolant pressure combine to make fission gas swelling a major contributor to clad deformation while the high clad ductility renders the distribution of strain readily observable. This has led to a detailed study of strain concentrations using the SEER code. SLEUTH and SEER have subsequently been used to specify power cycling and power ramp 112 experiments in water cooled, fast and materials testing reactors with the aim of developing a unified quantitative model of pellet-clad interaction whatever the reactor system. The FRUMP fuel behaviour code was developed specifically for the interpretation of fast reactor fuel pin behaviour. Experience with earlier models was valuable In its development. Originally the model was developed to describe behaviour during normal operation, but subsequently the code has been used extensively in the field of accident studies. Much of the effort in FRUMP development has been devoted to the production of physical models of the various effects of irradiation and the temperature gradients on the structure of the fuel and clad. Each process is modelled as well as is permitted by current knowledge and the limitations of computing costs. Each sub-model has a form which reflects the underlying mechanisms, where quantities are unknown values are assigned semi-empirically, i.e. coefficients

Operating manual for the Health Physics Research Reactor

International Nuclear Information System (INIS)

1985-11-01

This manual is intended to serve as a guide in the operation and maintenance of the Health Physics Researh Reactor (HPRR) of the Health Physics Dosimetry Applications Research (DOSAR) Facility. It includes descriptions of the HPRR and of associated equipment such as the reactor positioning devises and the derrick. Procedures for routine operation of the HPRR are given in detail, and checklists for the various steps are provided where applicable. Emergency procedures are similarly covered, and maintenance schedules are outlined. Also, a bibliography of references giving more detailed information on the DOSAR Facility is included. Changes to this manual will be approved by at least two of the following senior staff members: (1) the Operations Division Director, (2) the Reactor Operations Department Head, (3) the Supervisor of Reactor Operations TSF-HPRR Areas. The master copy and the copy of the manual issued to the HPRR Operations Supervisor will always reflect the latest revision. 22 figs

Oligonucleotide PIK3CA/Chromosome 3 Dual in Situ Hybridization Automated Assay with Improved Signals, One-Hour Hybridization, and No Use of Blocking DNA.

Science.gov (United States)

Zhang, Wenjun; Hubbard, Antony; Baca-Parkinson, Leslie; Stanislaw, Stacey; Vladich, Frank; Robida, Mark D; Grille, James G; Maxwell, Daniel; Tsao, Tsu-Shuen; Carroll, William; Gardner, Tracie; Clements, June; Singh, Shalini; Tang, Lei

2015-09-01

The PIK3CA gene at chromosome 3q26.32 was found to be amplified in up to 45% of patients with squamous cell carcinoma of the lung. The strong correlation between PIK3CA amplification and increased phosphatidylinositol 3-kinase (PI3K) pathway activities suggested that PIK3CA gene copy number is a potential predictive biomarker for PI3K inhibitors. Currently, all microscopic assessments of PIK3CA and chromosome 3 (CHR3) copy numbers use fluorescence in situ hybridization. PIK3CA probes are derived from bacterial artificial chromosomes whereas CHR3 probes are derived mainly from the plasmid pHS05. These manual fluorescence in situ hybridization assays mandate 12- to 18-hour hybridization and use of blocking DNA from human sources. Moreover, fluorescence in situ hybridization studies provide limited morphologic assessment and suffer from signal decay. We developed an oligonucleotide-based bright-field in situ hybridization assay that overcomes these shortcomings. This assay requires only a 1-hour hybridization with no need for blocking DNA followed by indirect chromogenic detection. Oligonucleotide probes produced discrete and uniform CHR3 stains superior to those from the pHS05 plasmid. This assay achieved successful staining in 100% of the 195 lung squamous cell carcinoma resections and in 94% of the 33 fine-needle aspirates. This robust automated bright-field dual in situ hybridization assay for the simultaneous detection of PIK3CA and CHR3 centromere provides a potential clinical diagnostic method to assess PIK3CA gene abnormality in lung tumors. Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

A multi-physics analysis for the actuation of the SSS in opal reactor

Directory of Open Access Journals (Sweden)

Ferraro Diego

2018-01-01

Full Text Available OPAL is a 20 MWth multi-purpose open-pool type Research Reactor located at Lucas Heights, Australia. It was designed, built and commissioned by INVAP between 2000 and 2006 and it has been operated by the Australia Nuclear Science and Technology Organization (ANSTO showing a very good overall performance. On November 2016, OPAL reached 10 years of continuous operation, becoming one of the most reliable and available in its kind worldwide, with an unbeaten record of being fully operational 307 days a year. One of the enhanced safety features present in this state-of-art reactor is the availability of an independent, diverse and redundant Second Shutdown System (SSS, which consists in the drainage of the heavy water reflector contained in the Reflector Vessel. As far as high quality experimental data is available from reactor commissioning and operation stages and even from early component design validation stages, several models both regarding neutronic and thermo-hydraulic approaches have been developed during recent years using advanced calculations tools and the novel capabilities to couple them. These advanced models were developed in order to assess the capability of such codes to simulate and predict complex behaviours and develop highly detail analysis. In this framework, INVAP developed a three-dimensional CFD model that represents the detailed hydraulic behaviour of the Second Shutdown System for an actuation scenario, where the heavy water drainage 3D temporal profiles inside the Reflector Vessel can be obtained. This model was validated, comparing the computational results with experimental measurements performed in a real-size physical model built by INVAP during early OPAL design engineering stages. Furthermore, detailed 3D Serpent Monte Carlo models are also available, which have been already validated with experimental data from reactor commissioning and operating cycles. In the present work the neutronic and thermohydraulic

A multi-physics analysis for the actuation of the SSS in opal reactor

Science.gov (United States)

Ferraro, Diego; Alberto, Patricio; Villarino, Eduardo; Doval, Alicia

2018-05-01

OPAL is a 20 MWth multi-purpose open-pool type Research Reactor located at Lucas Heights, Australia. It was designed, built and commissioned by INVAP between 2000 and 2006 and it has been operated by the Australia Nuclear Science and Technology Organization (ANSTO) showing a very good overall performance. On November 2016, OPAL reached 10 years of continuous operation, becoming one of the most reliable and available in its kind worldwide, with an unbeaten record of being fully operational 307 days a year. One of the enhanced safety features present in this state-of-art reactor is the availability of an independent, diverse and redundant Second Shutdown System (SSS), which consists in the drainage of the heavy water reflector contained in the Reflector Vessel. As far as high quality experimental data is available from reactor commissioning and operation stages and even from early component design validation stages, several models both regarding neutronic and thermo-hydraulic approaches have been developed during recent years using advanced calculations tools and the novel capabilities to couple them. These advanced models were developed in order to assess the capability of such codes to simulate and predict complex behaviours and develop highly detail analysis. In this framework, INVAP developed a three-dimensional CFD model that represents the detailed hydraulic behaviour of the Second Shutdown System for an actuation scenario, where the heavy water drainage 3D temporal profiles inside the Reflector Vessel can be obtained. This model was validated, comparing the computational results with experimental measurements performed in a real-size physical model built by INVAP during early OPAL design engineering stages. Furthermore, detailed 3D Serpent Monte Carlo models are also available, which have been already validated with experimental data from reactor commissioning and operating cycles. In the present work the neutronic and thermohydraulic models, available for

Reactor physics in support of the naval nuclear propulsion programme

International Nuclear Information System (INIS)

Lisley, P.G.; Beeley, P.A.

1994-01-01

Reactor physics is a core component of all courses but in particular two postgraduate courses taught at the department in support of the naval nuclear propulsion programme. All of the courses include the following elements: lectures and problem solving exercises, laboratory work, experiments on the Jason zero power Argonaut reactor, demonstration of PWR behavior on a digital computer simulator and project work. This paper will highlight the emphasis on reactor physics in all elements of the education and training programme. (authors). 9 refs

Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas.

Science.gov (United States)

Yamaguchi, Hiroshi; Kuboki, Yuko; Hatori, Takashi; Yamamoto, Masakazu; Shiratori, Keiko; Kawamura, Shunji; Kobayashi, Makio; Shimizu, Michio; Ban, Shinichi; Koyama, Isamu; Higashi, Morihiro; Shin, Nobuhiro; Ishida, Kazuyuki; Morikawa, Takanori; Motoi, Fuyuhiko; Unno, Michiaki; Kanno, Atsushi; Satoh, Kennichi; Shimosegawa, Tooru; Orikasa, Hideki; Watanabe, Tomoo; Nishimura, Kazuhiko; Harada, Youji; Furukawa, Toru

2011-12-01

Intraductal tubulopapillary neoplasm (ITPN) is a recently recognized rare variant of intraductal neoplasms of the pancreas. Molecular aberrations underlying the neoplasm remain unknown. We investigated somatic mutations in PIK3CA, PTEN, AKT1, KRAS, and BRAF. We also investigated aberrant expressions of phosphorylated AKT, phosphatase and tensin homolog (PTEN), tumor protein 53 (TP53), SMAD4, and CTNNB1 in 11 cases of ITPNs and compared these data with those of 50 cases of intraductal papillary mucinous neoplasm (IPMN), another distinct variant of pancreatic intraductal neoplasms. Mutations in PIK3CA were found in 3 of 11 ITPNs but not in IPMNs (P = 0.005; Fisher exact test). In contrast, mutations in KRAS were found in none of the ITPNs but were found in 26 of the 50 IPMNs (P = 0.001; Fisher exact test). PIK3CA mutations were associated with strong expression of phosphorylated AKT (P AKT was apparent in most ITPNs but only in a few IPMNs (P SMAD4, and CTNNB1 were not statistically different between these neoplasms. Mutations in PIK3CA and the expression of phosphorylated AKT were not associated with age, sex, tissue invasion, and patients' prognosis in ITPNs. These results indicate that activation of the phosphatidylinositol 3-kinase pathway may play a crucial role in ITPNs but not in IPMNs. In contrast, the mutation in KRAS seems to play a major role in IPMNs but not in ITPNs. The activated phosphatidylinositol 3-kinase pathway may be a potential target for molecular diagnosis and therapy of ITPNs.

10 CFR 73.60 - Additional requirements for physical protection at nonpower reactors.

Science.gov (United States)

2010-01-01

... nonpower reactors. 73.60 Section 73.60 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PHYSICAL PROTECTION... requirements for physical protection at nonpower reactors. Each nonpower reactor licensee who, pursuant to the... perform their duties. (6) Prior to entry into a material access area, packages shall be searched for...

1 kWe sodium borohydride hydrogen generation system Part II: Reactor modeling

OpenAIRE

Zhang, Jinsong; Zheng, Yuan; Gore, Jay P; Mudawar, Issam; Fisher, Timothy

2007-01-01

Sodium borohydride (NaBH4) hydrogen storage systems offer many advantages for hydrogen storage applications. The physical processes inside a NaBH4 packed bed reactor involve multi-component and multi-phase flow and multi-mode heat and mass transfer. These processes are also coupled with reaction kinetics. To guide reactor design and optimization, a reactor model involving all of these processes is desired. A onedimensional numerical model in conjunction with the assumption of homogeneous cata...

Nuclear data and integral experiments in reactor physics

International Nuclear Information System (INIS)

Farinelli, U.

1980-01-01

The material given here broadly covers the content of the 10 lectures delivered at the Winter Course on Reactor Theory and Power Reactors, ICTP, Trieste (13 February - 10 March 1978). However, the parts that could easily be found in the current literature have been omitted and replaced with the appropriate references. The needs for reactor physics calculations, particularly as applicable to commercial reactors, are reviewed in the introduction. The relative merits and shortcomings of fundamental and semi-empirical methods are discussed. The relative importance of different nuclear data, the ways in which they can be measured or calculated, and the sources of information on measured and evaluated data are briefly reviewed. The various approaches to the condensation of nuclear data to multigroup cross sections are described. After some consideration to the sensitivity calculations and the evaluation of errors, some of the most important type of integral experiments in reactor physics are introduced, with a view to showing the main difficulties in the interpretation and utilization of their results and the most recent trends in experimentation. The conclusions try to assign some priorities in the implementation of experimental and calculational capabilities, especially for a developing country. (author)

The use of personal computers in reactor physics

International Nuclear Information System (INIS)

Cullen, D.E.

1988-01-01

This paper points out that personal computers are now powerful enough (in terms of core size and speed) to allow them to be used for serious reactor physics applications. In addition the low cost of personal computers means that even small institutes can now have access to a significant amount of computer power. At the present time distribution centers, such as RSIC, are beginning to distribute reactor physics codes for use on personal computers; hopefully in the near future more and more of these codes will become available through distribution centers, such as RSIC

Technical specifications: Health Physics Research Reactor

International Nuclear Information System (INIS)

1986-03-01

These technical specifications define the key limitations that must be observed for safe operation of the Health Physics Research Reactor (HPRR) and an envelope of operation within which there is assurance that these limits will not be exceeded

Inspection methods for physical protection Task III review of other agencies' physical security activities for research reactors

International Nuclear Information System (INIS)

In Task I of this project, the current Nuclear Regulatory Commission (NRC) position-on physical security practices and procedures at research reactors were reviewed. In the second task, a sampling of the physical security plans was presented and the three actual reactor sites described in the security plans were visited. The purpose of Task III is to review other agencies' physical security activities for research reactors. During this phase, the actions, procedures and policies of two domestic and two foreign agencies other than the NRC that relate to the research reactor community were examined. The agencies examined were: International Atomic Energy Agency; Canadian Atomic Energy Control Board; Department of Energy; and American Nuclear Insurers

Full Core modeling techniques for research reactors with irregular geometries using Serpent and PARCS applied to the CROCUS reactor

International Nuclear Information System (INIS)

Siefman, Daniel J.; Girardin, Gaëtan; Rais, Adolfo; Pautz, Andreas; Hursin, Mathieu

2015-01-01

Highlights: • Modeling of research reactors. • Serpent and PARCS coupling. • Lattice physics codes modeling techniques. - Abstract: This paper summarizes the results of modeling methodologies developed for the zero-power (100 W) teaching and research reactor CROCUS located in the Laboratory for Reactor Physics and Systems Behavior (LRS) at the Swiss Federal Institute of Technology in Lausanne (EPFL). The study gives evidence that the Monte Carlo code Serpent can be used effectively as a lattice physics tool for small reactors. CROCUS’ core has an irregular geometry with two fuel zones of different lattice pitches. This and the reactor’s small size necessitate the use of nonstandard cross-section homogenization techniques when modeling the full core with a 3D nodal diffusion code (e.g. PARCS). The primary goal of this work is the development of these techniques for steady-state neutronics and future transient neutronics analyses of not only CROCUS, but research reactors in general. In addition, the modeling methods can provide useful insight for analyzing small modular reactor concepts based on light water technology. Static computational models of CROCUS with the codes Serpent and MCNP5 are presented and methodologies are analyzed for using Serpent and SerpentXS to prepare macroscopic homogenized group cross-sections for a pin-by-pin model of CROCUS with PARCS. The most accurate homogenization scheme lead to a difference in terms of k eff of 385 pcm between the Serpent and PARCS model, while the MCNP5 and Serpent models differed in terms of k eff by 13 pcm (within the statistical error of each simulation). Comparisons of the axial power profiles between the Serpent model as a reference and a set of PARCS models using different homogenization techniques showed a consistent root-mean-square deviation of ∼8%, indicating that the differences are not due to the homogenization technique but rather arise from the definition of the diffusion coefficients

Twenty years of health physics research reactor operation

International Nuclear Information System (INIS)

Sims, C.S.; Gilley, L.W.

1983-01-01

The Health Physics Research Reactor at the Oak Ridge National Laboratory has been in regular use for more than two decades. Safe operation of this fast reactor over this extended period indicates that (1) fundamental design, (2) operational procedures, (3) operator training and performance, (4) maintenance activites, and (5) management have all been eminently satisfactory. The reactor and its uses are described, the operational history and significant events are reviewed, and operational improvements and maintenance are discussed

Physical protection of power reactors

International Nuclear Information System (INIS)

Darby, J.L.

1979-01-01

Sandia Laboratories has applied a systematic approach to designing physical protection systems for nuclear facilities to commercial light-water reactor power plants. A number of candidate physical protection systems were developed and evaluated. Focus is placed on the design of access control subsystems at each of three plant layers: the protected area perimeter, building surfaces, and vital areas. Access control refers to barriers, detectors, and entry control devices and procedures used to keep unauthorized personnel and contraband out of the plant, and to control authorized entry into vital areas within the plant

Activity Report of Reactor Physics Division - 1997

International Nuclear Information System (INIS)

Singh, Om Pal

1998-01-01

The research and development activities of the Reactor Physics Division of the Indira Gandhi Centre for Atomic Research (IGCAR), Kalpakkam during 1997 are reported. The activities are arranged under the headings: nuclear data processing and validation, PFBR and KAMINI core physics, FBTR core physics, radioactivity and shielding and safety analysis. A list of publications of the Division and seminars delivered are included at the end of the report

Brief history of the reactor physics activities at ICN Pitesti

International Nuclear Information System (INIS)

Dumitrache, I.

2004-01-01

The Institute was established 33 years ago, in April 1971. Several specialists from the Institute for Atomic Physics - Bucharest came at the new research entity and the reactor physics activities had a successful start. One can identify three distinct periods: 1971-1980, the Bucharest years, 1980-1996, solving critical problems years and 1977-present (2004), technical support years. The first period is usually seen as a training one. This is only partially true. Most of the physicists came from University in 1971 and 1972 years. A significant number of them were trained abroad, in France, Germany, Italy, USA, Canada etc., usually under IAEA Vienna fellowships. The work was really pleasant and the progress was exciting. Unfortunately, the main task (to design a thermal reactor and a fast reactor, both for research activities) was, probably, much too difficult from the technical point of view and, in addition, required an unrealistic economic effort. In the Fall of the 1976 year, most of the reactor physicists were removed from Bucharest to Pitesti. One year later, all the remaining specialists were concentrated in Pitesti. The dual core TRIGA reactors were commissioned in the last months of the 1979 year. The CYBER 720 mainframe computer was available in December 1980. Between 1980 and 1992 years, practically all the Romanian activities related to reactor physics were performed in Pitesti, Mioveni compound. The details related to critical problems will be presented in the paper. We mention here four of the problems that have a significant impact even today, namely: -Final dimensioning of the adjuster rods for the Cernavoda NPP, Unit 2. The rods were manufactured in USA and Canada, using the AECL design and the final dimensions have been specified by ICN Pitesti; -Use of the LEU fuel in TRIGA-SSR Reactor, instead of the original HEU fuel; -Design of the irradiation experiments in TRIGA cores, in order to provide the required conditions during the test, according to

BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: Primary or secondary genetic events in colorectal carcinogenesis?

Directory of Open Access Journals (Sweden)

Schmitt Fernando

2008-09-01

Full Text Available Abstract Background BRAF, KRAS and PIK3CA mutations are frequently found in sporadic colorectal cancer (CRC. In contrast to KRAS and PIK3CA mutations, BRAF mutations are associated with tumours harbouring CpG Island methylation phenotype (CIMP, MLH1 methylation and microsatellite instability (MSI. We aimed at determine the frequency of KRAS, BRAF and PIK3CA mutations in the process of colorectal tumourigenesis using a series of colorectal polyps and carcinomas. In the series of polyps CIMP, MLH1 methylation and MSI were also studied. Methods Mutation analyses were performed by PCR/sequencing. Bisulfite treated DNA was used to study CIMP and MLH1 methylation. MSI was detected by pentaplex PCR and Genescan analysis of quasimonomorphic mononucleotide repeats. Chi Square test and Fisher's Exact test were used to perform association studies. Results KRAS, PIK3CA or BRAF occur in 71% of polyps and were mutually exclusive. KRAS mutations occur in 35% of polyps. PIK3CA was found in one of the polyps. V600E BRAF mutations occur in 29% of cases, all of them classified as serrated adenoma. CIMP phenotype occurred in 25% of the polyps and all were mutated for BRAF. MLH1 methylation was not detected and all the polyps were microsatellite stable. The comparison between the frequency of oncogenic mutations in polyps and CRC (MSI and MSS lead us to demonstrate that KRAS and PIK3CA are likely to precede both types of CRC. BRAF mutations are likely to precede MSI carcinomas since the frequency found in serrated polyps is similar to what is found in MSI CRC (P = 0.9112, but statistically different from what is found in microsatellite stable (MSS tumours (P = 0.0191. Conclusion Our results show that BRAF, KRAS and PIK3CA mutations occur prior to malignant transformation demonstrating that these oncogenic alterations are primary genetic events in colorectal carcinogenesis. Further, we show that BRAF mutations occur in association with CIMP phenotype in colorectal

BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: Primary or secondary genetic events in colorectal carcinogenesis?

International Nuclear Information System (INIS)

Velho, Sérgia; Moutinho, Cátia; Cirnes, Luís; Albuquerque, Cristina; Hamelin, Richard; Schmitt, Fernando; Carneiro, Fátima; Oliveira, Carla; Seruca, Raquel

2008-01-01

BRAF, KRAS and PIK3CA mutations are frequently found in sporadic colorectal cancer (CRC). In contrast to KRAS and PIK3CA mutations, BRAF mutations are associated with tumours harbouring CpG Island methylation phenotype (CIMP), MLH1 methylation and microsatellite instability (MSI). We aimed at determine the frequency of KRAS, BRAF and PIK3CA mutations in the process of colorectal tumourigenesis using a series of colorectal polyps and carcinomas. In the series of polyps CIMP, MLH1 methylation and MSI were also studied. Mutation analyses were performed by PCR/sequencing. Bisulfite treated DNA was used to study CIMP and MLH1 methylation. MSI was detected by pentaplex PCR and Genescan analysis of quasimonomorphic mononucleotide repeats. Chi Square test and Fisher's Exact test were used to perform association studies. KRAS, PIK3CA or BRAF occur in 71% of polyps and were mutually exclusive. KRAS mutations occur in 35% of polyps. PIK3CA was found in one of the polyps. V600E BRAF mutations occur in 29% of cases, all of them classified as serrated adenoma. CIMP phenotype occurred in 25% of the polyps and all were mutated for BRAF. MLH1 methylation was not detected and all the polyps were microsatellite stable. The comparison between the frequency of oncogenic mutations in polyps and CRC (MSI and MSS) lead us to demonstrate that KRAS and PIK3CA are likely to precede both types of CRC. BRAF mutations are likely to precede MSI carcinomas since the frequency found in serrated polyps is similar to what is found in MSI CRC (P = 0.9112), but statistically different from what is found in microsatellite stable (MSS) tumours (P = 0.0191). Our results show that BRAF, KRAS and PIK3CA mutations occur prior to malignant transformation demonstrating that these oncogenic alterations are primary genetic events in colorectal carcinogenesis. Further, we show that BRAF mutations occur in association with CIMP phenotype in colorectal serrated polyps and verified that colorectal serrated

Achievements and future directions in the reactors physics and nuclear safety research

International Nuclear Information System (INIS)

Dumitrache, Ion

2001-01-01

A historical overlook is presented with respect to inception and development of reactor physics research and on the job training in Romania. First these activities were carried out at the Institute for Atomic Physics and Institute for Power Reactors (IRNE) in Bucharest and afterward at the Institute for Nuclear Technologies, later on transformed in the Institute of Nuclear Research at Pitesti. CYBER Computer installed at Pitesti allowed formation in as early as 1971 reactor specialists who worked out computer programs for neutron physics calculations. These specialists were able to assimilate the characteristic of CANDU 6 type reactor as well as the AECL methodology of simulating processes of CANDU reactor physics. At present four programs are under way. These are: 1. The nuclear reactor physics; 2. The nuclear facility safety; 3. Safety analyses for the transport and radioactive waste disposal; 4. Analyses for radiation shielding and biological protection. There are presented results of the work associated to the CANDU type reactor: 1. Adapting and improving the code system for neutron and thermohydraulic calculation for CANDU type reactor, as supplied by AECL; 2. The IRNE manual for CANDU reactor neutron designing; 3. Final sizing of shim rods of Cernavoda NPP Unit 2; 4. Tests and measurements of reactor physics at the Cernavoda NPP Unit 1 commissioning; 5. Simulation and independent analysis of thermosiphoning carried out at Cernavoda NPP Unit 1 commissioning; 6. Static and dynamical response of the detectors in the CANDU reactor core and their time evolution following the burnup in the neutron flux and their ageing effects; 7. PSA studies at Unit 1; 8. Safety analyses for the radioactive waste disposal at Saligny repository. Also, reported are the results of the work associated to the TRIGA reactor, as follows: 1. Flux measurements and neutron computations necessary in the reactor commissioning; 2. Cleaning up controversial issues relating to neutron flux

Experimental Equipment for Physics Studies in the Aagesta Reactor

Energy Technology Data Exchange (ETDEWEB)

Bernander, G; Blomberg, P E; Dubois, P O

1967-03-15

Comprehensive physics measurements were carried out in connection with the start up of the Agesta reactor. For this purpose special experimental equipment was constructed and installed in the reactor. Parts of this were indispensable and/or time-saving for the reactivity control during the core build-up period and during the first criticality studies. This report gives mainly a detailed description of the experimental equipment used, but also the relevant physics background and the experience gained during the performance.

Reactor physics computations for nuclear engineering undergraduates

International Nuclear Information System (INIS)

Huria, H.C.

1989-01-01

The undergraduate program in nuclear engineering at the University of Cincinnati provides three-quarters of nuclear reactor theory that concentrate on physical principles, with calculations limited to those that can be conveniently completed on programmable calculators. An additional one-quarter course is designed to introduce the student to realistic core physics calculational methods, which necessarily requires a computer. Such calculations can be conveniently demonstrated and completed with the modern microcomputer. The one-quarter reactor computations course includes a one-group, one-dimensional diffusion code to introduce the concepts of inner and outer iterations, a cell spectrum code based on integral transport theory to generate cell-homogenized few-group cross sections, and a multigroup diffusion code to determine multiplication factors and power distributions in one-dimensional systems. Problem assignments include the determination of multiplication factors and flux distributions for typical pressurized water reactor (PWR) cores under various operating conditions, such as cold clean, hot clean, hot clean at full power, hot full power with xenon and samarium, and a boron concentration search. Moderator and Doppler coefficients can also be evaluated and examined

SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells.

Science.gov (United States)

Pasquier, Benoit

2015-04-03

Autophagy plays an important role in cancer and it has been suggested that it functions not only as a tumor suppressor pathway to prevent tumor initiation, but also as a prosurvival pathway that helps tumor cells endure metabolic stress and resist death triggered by chemotherapeutic agents. We recently described the discovery of inhibitors of PIK3C3/Vps34 (phosphatidylinositol 3-kinase, catalytic subunit type 3), the lipid kinase component of the class III phosphatidylinositol 3-kinase (PtdIns3K). This PtdIns3K isoform has attracted significant attention in recent years because of its role in autophagy. Following chemical optimization we identified SAR405, a low molecular mass kinase inhibitor of PIK3C3, highly potent and selective with regard to other lipid and protein kinases. We demonstrated that inhibiting the catalytic activity of PIK3C3 disrupts vesicle trafficking from late endosomes to lysosomes. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. Finally our results show that combining SAR405 with everolimus, the FDA-approved MTOR inhibitor, results in a significant synergy on the reduction of cell proliferation using renal tumor cells. This result indicates a potential therapeutic application for PIK3C3 inhibitors in cancer.

Assessing physical models used in nuclear aerosol transport models

International Nuclear Information System (INIS)

McDonald, B.H.

1987-01-01

Computer codes used to predict the behaviour of aerosols in water-cooled reactor containment buildings after severe accidents contain a variety of physical models. Special models are in place for describing agglomeration processes where small aerosol particles combine to form larger ones. Other models are used to calculate the rates at which aerosol particles are deposited on building structures. Condensation of steam on aerosol particles is currently a very active area in aerosol modelling. In this paper, the physical models incorporated in the current available international codes for all of these processes are reviewed and documented. There is considerable variation in models used in different codes, and some uncertainties exist as to which models are superior. 28 refs

Thermal-Hydraulics analysis of pressurized water reactor core by using single heated channel model

Directory of Open Access Journals (Sweden)

Reza Akbari

2017-08-01

Full Text Available Thermal hydraulics of nuclear reactor as a basis of reactor safety has a very important role in reactor design and control. The thermal-hydraulic analysis provides input data to the reactor-physics analysis, whereas the latter gives information about the distribution of heat sources, which is needed to perform the thermal-hydraulic analysis. In this study single heated channel model as a very fast model for predicting thermal hydraulics behavior of pressurized water reactor core has been developed. For verifying the results of this model, we used RELAP5 code as US nuclear regulatory approved thermal hydraulics code. The results of developed single heated channel model have been checked with RELAP5 results for WWER-1000. This comparison shows the capability of single heated channel model for predicting thermal hydraulics behavior of reactor core.

Proceedings of the 1992 topical meeting on advances in reactor physics. Volume 2

Energy Technology Data Exchange (ETDEWEB)

1992-04-01

This document, Volume 2, presents proceedings of the 1992 Topical Meeting on Advances in Reactor Physics on March 8--11, 1992 at Charleston, SC. Session topics were as follows: Transport Theory; Fast Reactors; Plant Analyzers; Integral Experiments/Measurements & Analysis; Core Computational Systems; Reactor Physics; Monte Carlo; Safety Aspects of Heavy Water Reactors; and Space-Time Core Kinetics. The individual reports have been cataloged separately. (FI)

IAEA Coordinated Research Project on HTGR Reactor Physics, Thermal-hydraulics and Depletion Uncertainty Analysis

Energy Technology Data Exchange (ETDEWEB)

Strydom, Gerhard [Idaho National Lab. (INL), Idaho Falls, ID (United States); Bostelmann, F. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2015-09-01

The continued development of High Temperature Gas Cooled Reactors (HTGRs) requires verification of HTGR design and safety features with reliable high fidelity physics models and robust, efficient, and accurate codes. The predictive capability of coupled neutronics/thermal-hydraulics and depletion simulations for reactor design and safety analysis can be assessed with sensitivity analysis (SA) and uncertainty analysis (UA) methods. Uncertainty originates from errors in physical data, manufacturing uncertainties, modelling and computational algorithms. (The interested reader is referred to the large body of published SA and UA literature for a more complete overview of the various types of uncertainties, methodologies and results obtained). SA is helpful for ranking the various sources of uncertainty and error in the results of core analyses. SA and UA are required to address cost, safety, and licensing needs and should be applied to all aspects of reactor multi-physics simulation. SA and UA can guide experimental, modelling, and algorithm research and development. Current SA and UA rely either on derivative-based methods such as stochastic sampling methods or on generalized perturbation theory to obtain sensitivity coefficients. Neither approach addresses all needs. In order to benefit from recent advances in modelling and simulation and the availability of new covariance data (nuclear data uncertainties) extensive sensitivity and uncertainty studies are needed for quantification of the impact of different sources of uncertainties on the design and safety parameters of HTGRs. Only a parallel effort in advanced simulation and in nuclear data improvement will be able to provide designers with more robust and well validated calculation tools to meet design target accuracies. In February 2009, the Technical Working Group on Gas-Cooled Reactors (TWG-GCR) of the International Atomic Energy Agency (IAEA) recommended that the proposed Coordinated Research Program (CRP) on

Comparative study of cost models for tokamak DEMO fusion reactors

International Nuclear Information System (INIS)

Oishi, Tetsutarou; Yamazaki, Kozo; Arimoto, Hideki; Ban, Kanae; Kondo, Takuya; Tobita, Kenji; Goto, Takuya

2012-01-01

Cost evaluation analysis of the tokamak-type demonstration reactor DEMO using the PEC (physics-engineering-cost) system code is underway to establish a cost evaluation model for the DEMO reactor design. As a reference case, a DEMO reactor with reference to the SSTR (steady state tokamak reactor) was designed using PEC code. The calculated total capital cost was in the same order of that proposed previously in cost evaluation studies for the SSTR. Design parameter scanning analysis and multi regression analysis illustrated the effect of parameters on the total capital cost. The capital cost was predicted to be inside the range of several thousands of M$s in this study. (author)

Antitumor Efficacy of the Dual PI3K/mTOR Inhibitor PF-04691502 in a Human Xenograft Tumor Model Derived from Colorectal Cancer Stem Cells Harboring a PIK3CA Mutation.

Directory of Open Access Journals (Sweden)

Douglas D Fang

Full Text Available PIK3CA (phosphoinositide-3-kinase, catalytic, alpha polypeptide mutations can help predict the antitumor activity of phosphatidylinositol-3-kinase (PI3K/mammalian target of rapamycin (mTOR pathway inhibitors in both preclinical and clinical settings. In light of the recent discovery of tumor-initiating cancer stem cells (CSCs in various tumor types, we developed an in vitro CSC model from xenograft tumors established in mice from a colorectal cancer patient tumor in which the CD133+/EpCAM+ population represented tumor-initiating cells. CD133+/EpCAM+ CSCs were enriched under stem cell culture conditions and formed 3-dimensional tumor spheroids. Tumor spheroid cells exhibited CSC properties, including the capability for differentiation and self-renewal, higher tumorigenic potential and chemo-resistance. Genetic analysis using an OncoCarta™ panel revealed a PIK3CA (H1047R mutation in these cells. Using a dual PI3K/mTOR inhibitor, PF-04691502, we then showed that blockage of the PI3K/mTOR pathway inhibited the in vitro proliferation of CSCs and in vivo xenograft tumor growth with manageable toxicity. Tumor growth inhibition in mice was accompanied by a significant reduction of phosphorylated Akt (pAKT (S473, a well-established surrogate biomarker of PI3K/mTOR signaling pathway inhibition. Collectively, our data suggest that PF-04691502 exhibits potent anticancer activity in colorectal cancer by targeting both PIK3CA (H1047R mutant CSCs and their derivatives. These results may assist in the clinical development of PF-04691502 for the treatment of a subpopulation of colorectal cancer patients with poor outcomes.

On the research activities in reactor and neutron physics using the first egyptian research reactor

International Nuclear Information System (INIS)

Hassan, A.M.

2000-01-01

A review on the most important research activities in reactor and neutron physics using the first Egyptian Research Reactor (ET-RR-1) is given. An out look on: neutron cross-sections, neutron flux, neutron capture gamma-ray spectroscopy, neutron activation analysis, neutron diffraction and radiation shielding experiments, is presented

Reactor physics activities in NEA member countries

International Nuclear Information System (INIS)

1990-01-01

This document is a compilation of National activity reports presented at the thirty-third Meeting of the NEA Committee on Reactor Physics, held at OECD Headquarters, Paris, from 15th - 19th October 1990

Reactor physics tests of TRIGA Mark-II Reactor in Ljubljana

International Nuclear Information System (INIS)

Ravnik, M.; Mele, I.; Trkov, A.; Rant, J.; Glumac, B.; Dimic, V.

2008-01-01

TRIGA Mark-II Reactor in Ljubljana was recently reconstructed. The reconstruction consisted mainly of replacing the grid plates, the control rod mechanisms and the control unit. The standard type control rods were replaced by the fuelled follower type, the central grid location (A ring) was adapted for fuel element insertion, the triangular cutouts were introduced in the upper plate design. However, the main novelty in reactor physics and operational features of the reactor was the installation of a pulse rod. Having no previous operational experience in pulsing, a detailed and systematic sequence of tests was defined in order to check the predicted design parameters of the reactor with measurements. The following experiments are treated in this paper: initial criticality, excess reactivity measurements, control rod worth measurement, fuel temperature distribution, fuel temperature reactivity coefficient, pulse parameters measurement (peak power, prompt energy, peak temperature). Flux distributions in steady state and pulse mode were measured as well, however, they are treated only briefly due to the volume of the results. The experiments were performed with completely fresh fuel of 12 w% enriched Standard Stainless Steel type. The core configuration was uniform (one fuel element type, including fuelled followers) and compact (no irradiation channels or gaps), as such being particularly convenient for testing the computer codes for TRIGA reactor calculations. Comparison of analytical predictions, obtained with WIMS, SLXTUS, TRIGAP and PULSTRI codes to measured values showed agreement within the error of the measurement and calculation. The paper has the following contents: 1. Introduction; 2. Steady State Experiments; 2.1. Core loading and critical experiment; 2.2. Flux range determination for tests at zero power; 2.3. Digital reactivity meter checkout; 2.4. Control rod worth measurements; 2.5. Excess reactivity measurement; 2.6. Thermal power calibration; 2

A global model for gas cooled reactors for the Generation-4: application to the Very High Temperature Reactor (VHTR)

International Nuclear Information System (INIS)

Limaiem, I.

2006-12-01

Gas cooled high temperature reactor (HTR) belongs to the new generation of nuclear power plants called Generation IV. The Generation IV gathers the entire future nuclear reactors concept with an effective deployment by 2050. The technological choices relating to the nature of the fuel, the moderator and the coolant as well as the annular geometry of the core lead to some physical characteristics. The most important of these characteristics is the very strong thermal feedback in both active zone and the reflectors. Consequently, HTR physics study requires taking into account the strong coupling between neutronic and thermal hydraulics. The work achieved in this Phd consists in modeling, programming and studying of the neutronic and thermal hydraulics coupling system for block type gas cooled HTR. The coupling system uses a separate resolution of the neutronic and thermal hydraulics problems. The neutronic scheme is a double level Transport (APOLLO2) /Diffusion (CRONOS2) scheme respectively on the scale of the fuel assembly and a reactor core scale. The thermal hydraulics model uses simplified Navier Stokes equations solved in homogeneous porous media in code CAST3M CFD code. A generic homogenization model is used to calculate the thermal hydraulics parameters of the porous media. A de-homogenization model ensures the link between the porous media temperatures of the temperature defined in the neutronic model. The coupling system is made by external procedures communicating between the thermal hydraulics and neutronic computer codes. This Phd thesis contributed to the Very High Temperature Reactor (VHTR) physics studies. In this field, we studied the VHTR core in normal operating mode. The studies concern the VHTR core equilibrium cycle with the control rods and using the neutronic and thermal hydraulics coupling system. These studies allowed the study of the equilibrium between the power, the temperature and Xenon. These studies open new perspective for core

Contribution to the modelling of gas-solid reactions and reactors

International Nuclear Information System (INIS)

Patisson, F.

2005-09-01

Gas-solid reactions control a great number of major industrial processes involving matter transformation. This dissertation aims at showing that mathematical modelling is a useful tool for both understanding phenomena and optimising processes. First, the physical processes associated with a gas-solid reaction are presented in detail for a single particle, together with the corresponding available kinetic grain models. A second part is devoted to the modelling of multiparticle reactors. Different approaches, notably for coupling grain models and reactor models, are illustrated through various case studies: coal pyrolysis in a rotary kiln, production of uranium tetrafluoride in a moving bed furnace, on-grate incineration of municipal solid wastes, thermogravimetric apparatus, nuclear fuel making, steel-making electric arc furnace. (author)

Using genetic algorithms for calibrating simplified models of nuclear reactor dynamics

International Nuclear Information System (INIS)

Marseguerra, Marzio; Zio, Enrico; Canetta, Raffaele

2004-01-01

In this paper the use of genetic algorithms for the estimation of the effective parameters of a model of nuclear reactor dynamics is investigated. The calibration of the effective parameters is achieved by best fitting the model responses of the quantities of interest (e.g., reactor power, average fuel and coolant temperatures) to the actual evolution profiles, here simulated by the Quandry based reactor kinetics (Quark) code available from the Nuclear Energy Agency. Alternative schemes of single- and multi-objective optimization are investigated. The efficiency of convergence of the algorithm with respect to the different effective parameters to be calibrated is studied with reference to the physical relationships involved

Using genetic algorithms for calibrating simplified models of nuclear reactor dynamics

Energy Technology Data Exchange (ETDEWEB)

Marseguerra, Marzio E-mail: marzio.marseguerra@polimi.it; Zio, Enrico E-mail: enrico.zio@polimi.it; Canetta, Raffaele

2004-07-01

In this paper the use of genetic algorithms for the estimation of the effective parameters of a model of nuclear reactor dynamics is investigated. The calibration of the effective parameters is achieved by best fitting the model responses of the quantities of interest (e.g., reactor power, average fuel and coolant temperatures) to the actual evolution profiles, here simulated by the Quandry based reactor kinetics (Quark) code available from the Nuclear Energy Agency. Alternative schemes of single- and multi-objective optimization are investigated. The efficiency of convergence of the algorithm with respect to the different effective parameters to be calibrated is studied with reference to the physical relationships involved.

Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors

International Nuclear Information System (INIS)

Naguib, Adam; Arends, Mark J; Cooke, James C; Happerfield, Lisa; Kerr, Lucy; Gay, Laura J; Luben, Robert N; Ball, Richard Y; Mitrou, Panagiota N; McTaggart, Alison

2011-01-01

The PTEN tumour suppressor gene and PIK3CA proto-oncogene encode proteins which contribute to regulation and propagation of signal transduction through the PI3K/AKT signalling pathway. This study investigates the prevalence of loss of PTEN expression and mutations in both PTEN and PIK3CA in colorectal cancers (CRC) and their associations with tumour clinicopathological features, lifestyle factors and dietary consumptions. 186 adenocarcinomas and 16 adenomas from the EPIC Norfolk study were tested for PTEN and PIK3CA mutations by DNA sequencing and PTEN expression changes by immunohistochemistry. Dietary and lifestyle data were collected prospectively using seven day food diaries and lifestyle questionnaires. Mutations in exons 7 and 8 of PTEN were observed in 2.2% of CRC and PTEN loss of expression was identified in 34.9% CRC. Negative PTEN expression was associated with lower blood low-density lipoprotein concentrations (p = 0.05). PIK3CA mutations were observed in 7% of cancers and were more frequent in CRCs in females (p = 0.04). Analysis of dietary intakes demonstrated no link between PTEN expression status and any specific dietary factor. PTEN expression negative, proximal CRC were of more advanced Dukes' stage (p = 0.02) and poor differentiation (p < 0.01). Testing of the prevalence of PIK3CA mutations and loss of PTEN expression demonstrated that these two events were independent (p = 0.55). These data demonstrated the frequent occurrence (34.9%) of PTEN loss of expression in colorectal cancers, for which gene mutations do not appear to be the main cause. Furthermore, dietary factors are not associated with loss of PTEN expression. PTEN expression negative CRC were not homogenous, as proximal cancers were associated with a more advanced Dukes' stage and poor differentiation, whereas distal cancers were associated with earlier Dukes' stage

Proceedings of 2. Yugoslav symposium on reactor physics, Part 2, Herceg Novi (Yugoslavia), 27-29 Sep 1966

International Nuclear Information System (INIS)

1966-01-01

This Volume 2 of the Proceedings of 2. Yugoslav symposium on reactor physics includes eight papers dealing with the following topics: method for measuring high anti reactivities of a reactor system; integration method for thermal reaction rate calculation; Determination of initial core configuration for BHWR-200 MWe; safety shutdowns and failures of the RA reactor equipment; determining the reactivity of absorption rods; measurements of thermal and fast neutron fluxes at the TRIGA reactor and other measurements during operation of the TRIGA reactor; mathematical modelling of the reactor safety; review of problems and methods for radiation risk assessment in the environment of a nuclear power plant

Neutron transport. Physics and calculation of nuclear reactors with applications to pressurized water reactors and fast neutron reactors. 2 ed.

International Nuclear Information System (INIS)

Bussac, J.; Reuss, P.

1985-01-01

This book presents the main physical bases of neutron theory and nuclear reactor calculation. 1) Interactions of neutrons with matter and basic principles of neutron transport; 2) Neutron transport in homogeneous medium and the neutron field: kinetic behaviour, slowing-down, resonance absorption, diffusion equation, processing methods; 3) Theory of a reactor constituted with homogeneous zones: critical condition, kinetics, separation of variables, calculation and neutron balance of the fundamental mode, one-group and multigroup theories; 4) Study of heterogeneous cell lattices: fast fission factor, resonance absorption, thermal output factor, diffusion coefficient, computer codes; 5) Operation and control of reactors: perturbation theory, reactivity, fuel properties evolution, poisoning by fission products, calculation of a reactor and fuel management; 6) Study of some types of reactors: PWR and fast breeder reactors, the main reactor types of the present French program [fr

PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation

OpenAIRE

Anderson, Grace R.; Wardell, Suzanne E.; Cakir, Merve; Crawford, Lorin; Leeds, Jim C.; Nussbaum, Daniel P.; Shankar, Pallavi S.; Soderquist, Ryan S.; Stein, Elizabeth M.; Tingley, Jennifer P.; Winter, Peter S.; Zieser-Misenheimer, Elizabeth K.; Alley, Holly M.; Yllanes, Alexander; Haney, Victoria

2016-01-01

Therapies that efficiently induce apoptosis are likely to be required for durable clinical responses in patients with solid tumors. Using a pharmacological screening approach, we discovered that the combined inhibition of BCL-XL and the mTOR/4E-BP axis results in selective and synergistic induction of apoptosis in cellular and animal models of PIK3CA mutant breast cancers, including triple negative tumors. Mechanistically, inhibition of mTOR/4E-BP suppresses MCL-1 protein translation only in ...

Franco-German cooperation for the physical protection of the EPR reactor

International Nuclear Information System (INIS)

Jalouneix, J.; Hagemann, A.

2001-01-01

This article presents the proceeding that has been followed in the EPR (European pressurized water reactor) project concerning physical protection against malevolent actions and robbery of nuclear materials. Before the different options of the nuclear island were definitely set, a task group had been constituted to examine if these options could hamper the setting of physical protection measures that are required by the legislation of the 2 countries. Another group composed of experts from IPSN/GRS (Institut de Protection et de Surete Nucleaire / Gesellschaft fur Anlagen und Reaktorsicherheit) had the task to define common requirements concerning the physical protection of reactors in Germany and in France. In this framework the EPR project team has prepared a technical document reviewing the different dispositions that have been retained to assure the physical protection of the reactor. (A.C.)

Lessons from feedback of safety operating experience for reactor physics

International Nuclear Information System (INIS)

Suchomel, J.; Rapavy, S.

1999-01-01

Analyses of events in WWER operations as a part of safety experience feedback provide a valuable source of lessons for reactor physics. Examples of events from Bohunice operation will be shown such as events with inadequate approach to criticality, positive reactivity insertions, expulsion of a control rod from shut-down reactor, problems with reactor protection system and control rods. (Authors)

Fuel Management Study for a CANDU reactor Using New Physics Codes Suite

International Nuclear Information System (INIS)

Kim, Won Young; Kim, Bong Ghi; Park, Joo Hwan

2008-01-01

A CANDU reactor is a heavy-water-moderated, natural uranium fuelled reactor with a pressure tube. The reactor contains a horizontal cylindrical vessel (calandria) and each pressure tube is isolated from the heavy-water moderator in a calandria. This allows the moderator system to be operated of a high-pressure and of a high-temperature coolant in pressure tube. The primary reactivity control in a CANDU reactor is the on-power refueling on a daily basis and an additional reactivity control is provided through an individual reactivity device movement, which includes 21 adjusters, 6 liquid zone controllers, 4 mechanical control absorbers and 2 shutdown systems. The refueling in CANDU is carried out on power and this makes the in-core fuel management different from that in a reactor refueled during shutdowns. The objective of a fuel management is to determine a fuel loading and fuel replacement procedure which will result in a minimum total unit energy cost in a safe and reliable operation. In this article, the in-core fuel management for the CANDU reactor was studied by using the new physics code suite of WIMS-IST/DRAGON-IST/RFSP-IST with the model of Wolsong-1 NPP

Summary of ORSphere critical and reactor physics measurements

Directory of Open Access Journals (Sweden)

Marshall Margaret A.

2017-01-01

Full Text Available In the early 1970s Dr. John T. Mihalczo (team leader, J.J. Lynn, and J.R. Taylor performed experiments at the Oak Ridge Critical Experiments Facility (ORCEF with highly enriched uranium (HEU metal (called Oak Ridge Alloy or ORALLOY to recreate GODIVA I results with greater accuracy than those performed at Los Alamos National Laboratory in the 1950s. The purpose of the Oak Ridge ORALLOY Sphere (ORSphere experiments was to estimate the unreflected and unmoderated critical mass of an idealized sphere of uranium metal corrected to a density, purity, and enrichment such that it could be compared with the GODIVA I experiments. This critical configuration has been evaluated. Preliminary results were presented at ND2013. Since then, the evaluation was finalized and judged to be an acceptable benchmark experiment for the International Criticality Safety Benchmark Experiment Project (ICSBEP. Additionally, reactor physics measurements were performed to determine surface button worths, central void worth, delayed neutron fraction, prompt neutron decay constant, fission density and neutron importance. These measurements have been evaluated and found to be acceptable experiments and are discussed in full detail in the International Handbook of Evaluated Reactor Physics Benchmark Experiments. The purpose of this paper is to summarize all the evaluated critical and reactor physics measurements evaluations.

Summary of ORSphere critical and reactor physics measurements

Science.gov (United States)

Marshall, Margaret A.; Bess, John D.

2017-09-01

In the early 1970s Dr. John T. Mihalczo (team leader), J.J. Lynn, and J.R. Taylor performed experiments at the Oak Ridge Critical Experiments Facility (ORCEF) with highly enriched uranium (HEU) metal (called Oak Ridge Alloy or ORALLOY) to recreate GODIVA I results with greater accuracy than those performed at Los Alamos National Laboratory in the 1950s. The purpose of the Oak Ridge ORALLOY Sphere (ORSphere) experiments was to estimate the unreflected and unmoderated critical mass of an idealized sphere of uranium metal corrected to a density, purity, and enrichment such that it could be compared with the GODIVA I experiments. This critical configuration has been evaluated. Preliminary results were presented at ND2013. Since then, the evaluation was finalized and judged to be an acceptable benchmark experiment for the International Criticality Safety Benchmark Experiment Project (ICSBEP). Additionally, reactor physics measurements were performed to determine surface button worths, central void worth, delayed neutron fraction, prompt neutron decay constant, fission density and neutron importance. These measurements have been evaluated and found to be acceptable experiments and are discussed in full detail in the International Handbook of Evaluated Reactor Physics Benchmark Experiments. The purpose of this paper is to summarize all the evaluated critical and reactor physics measurements evaluations.

Modelling of Control Bars in Calculations of Boiling Water Reactors

International Nuclear Information System (INIS)

Khlaifi, A.; Buiron, L.

2004-01-01

The core of a nuclear reactor is generally composed of a neat assemblies of fissile material from where neutrons were descended. In general, the energy of fission is extracted by a fluid serving to cool clusters. A reflector is arranged around the assemblies to reduce escaping of neutrons. This is made outside the reactor core. Different mechanisms of reactivity are generally necessary to control the chain reaction. Manoeuvring of Boiling Water Reactor takes place by controlling insertion of absorbent rods to various places of the core. If no blocked assembly calculations are known and mastered, blocked assembly neutronic calculation are delicate and often treated by case to case in present studies [1]. Answering the question how to model crossbar for the control of a boiling water reactor ? requires the choice of a representation level for every chain of variables, the physical model, and its representing equations, etc. The aim of this study is to select the best applicable parameter serving to calculate blocked assembly of a Boiling Water Reactor. This will be made through a range of representative configurations of these reactors and used absorbing environment, in order to illustrate strategies of modelling in the case of an industrial calculation. (authors)

Discussion of the use of the Dragon reactor as a facility for integral reactor physics experiments

Energy Technology Data Exchange (ETDEWEB)

Gutmann, H

1972-06-05

The purpose and use of the Dragon Reactor Experiment (DRE) has changed considerably during the years of its operation. The original purpose was to show that the principle of a High Temperature Reactor is sound and demonstrate its operation. After this achievement, the purpose of the Dragon reactor changed to the use as a fuel testing facility. During recent years, a new use of the DRE has been added to its use as a fuel testing facility, namely Fuel Element Design Testing. The current report covers reactor physics experiments aspects.

Relative quantification of PIK3CA gene expression level in fine-needle aspiration biopsy thyroid specimens collected from patients with papillary thyroid carcinoma and non-toxic goitre by real-time RT-PCR

Directory of Open Access Journals (Sweden)

Wojciechowska-Durczyńska Katarzyna

2010-08-01

Full Text Available Abstract Background Recent studies have shown that the phosphatidylinositol 3-kinase (PI3K signaling pathway is important regulator of many cellular events, including apoptosis, proliferation and motility. PI3K pathway alterations (PIK3CA gene mutations and/or amplification have been observed in various human tumours. In the majority of diagnosed cases, mutations are localized in one of the three "hot spots" in the gene, responsible for coding catalytic subunit α of class I PI3K (PIK3CA. Mutations and amplification of PIK3CA gene are characteristic for thyroid cancer, as well. Methods The aim of our study was to examine a gene expression level of PIK3CA in fine-needle aspiration biopsy (FNAB thyroid specimens in two types of thyroid lesions, papillary thyroid carcinoma (PTC and non-toxic goitre (NTG. Following conventional cytological examination, 42 thyroid FNAB specimens, received from patients with PTC (n = 20 and NTG (n = 22, were quantitatively evaluated regarding PIK3CA expression level by real-time PCR in the ABI PRISM® 7500 Sequence Detection System. Results Significantly higher expression level (RQ of PIK3CA in PTC group has been noted in comparison with NTG group (p Conclusion These observations may suggest role of PIK3CA alterations in PTC carcinogenesis.

Physics design of the upgraded TREAT reactor

International Nuclear Information System (INIS)

Bhattacharyya, S.K.; Lell, R.M.; Liaw, J.R.; Ulrich, A.J.; Wade, D.C.; Yang, S.T.

1980-01-01

With the deferral of the Safety Test Facility (STF), the TREAT Upgrade (TU) reactor has assumed a lead role in the US LMFBR safety test program for the foreseeable future. The functional requirements on TU require a significant enhancement of the capability of the current TREAT reactor. A design of the TU reactor has been developed that modifies the central 11 x 11 fuel assembly array of the TREAT reactor such as to provide the increased source of hard spectrum neutrons necessary to meet the functional requirements. A safety consequence of the increased demands on TU is that the self limiting operation capability of TREAT has proved unattainable, and reliance on a safety grade Plant Protection System is necessary to ensure that no clad damage occurs under postulated low-probability reactivity accidents. With that constraint, the physics design of TU provides a means of meeting the functional requirements with a high degree of confidence

Reactor physics computer code development for neutronic design, fuel-management, reactor operation and safety analysis of PHWRs

International Nuclear Information System (INIS)

Rastogi, B.P.

1989-01-01

This report discusses various reactor physics codes developed for neutronic design, fuel-management, reactor operation and safety analysis of PHWRs. These code packages have been utilized for nuclear design of 500 MWe and new 235 MWe PHWRs. (author)

International Conference on Physics and Technology of Reactors and Applications

International Nuclear Information System (INIS)

2007-01-01

The first international conference on physics and technology of reactors and applications (PHYTRA 1) which took place in Marrakech (Morocco) from 14 to 16 March 2007, was designed to bring together scientists, teachers and students from universities, research centres and industry and other institutions to exchange knowledge and to discuss ideas and future issues. The programmes of the PHYTRA 1 conference covers a wide variety topics, the conference was organised in three plenary sessions, ten oral technical sessions and two poster sessions. The plenary sessions covers the following topics : The prospects of nuclear energy, The situation of nuclear sciences and energy in Morocco and Africa, and the new development in reactor physics and reactor design [fr

Characterisation of mutations of the phosphoinositide-3-kinase regulatory subunit, PIK3R2, in perisylvian polymicrogyria: a next-generation sequencing study.

Science.gov (United States)

Mirzaa, Ghayda M; Conti, Valerio; Timms, Andrew E; Smyser, Christopher D; Ahmed, Sarah; Carter, Melissa; Barnett, Sarah; Hufnagel, Robert B; Goldstein, Amy; Narumi-Kishimoto, Yoko; Olds, Carissa; Collins, Sarah; Johnston, Kathreen; Deleuze, Jean-François; Nitschké, Patrick; Friend, Kathryn; Harris, Catharine; Goetsch, Allison; Martin, Beth; Boyle, Evan August; Parrini, Elena; Mei, Davide; Tattini, Lorenzo; Slavotinek, Anne; Blair, Ed; Barnett, Christopher; Shendure, Jay; Chelly, Jamel; Dobyns, William B; Guerrini, Renzo

2015-12-01

Bilateral perisylvian polymicrogyria (BPP), the most common form of regional polymicrogyria, causes the congenital bilateral perisylvian syndrome, featuring oromotor dysfunction, cognitive impairment, and epilepsy. The causes of BPP are heterogeneous, but only a few genetic causes have been reported. The aim of this study was to identify additional genetic causes of BPP and characterise their frequency in this population. Children (aged ≤18 years) with polymicrogyria were enrolled into our research programme from July, 1980, to October, 2015, at two centres (Florence, Italy, and Seattle, WA, USA). We obtained samples (blood and saliva) throughout this period at both centres and did whole-exome sequencing on DNA from eight trios (two parents and one affected child) with BPP in 2014. After the identification of mosaic PIK3R2 mutations in two of these eight children, we performed targeted screening of PIK3R2 by two methods in a cohort of 118 children with BPP. First, we performed targeted sequencing of the entire PIK3R2 gene by single molecule molecular inversion probes (smMIPs) on 38 patients with BPP with normal to large head size. Second, we did amplicon sequencing of the recurrent PIK3R2 mutation (Gly373Arg) in 80 children with various types of polymicrogyria including BPP. One additional patient had clinical whole-exome sequencing done independently, and was included in this study because of the phenotypic similarity to our cohort. We identified a mosaic mutation (Gly373Arg) in a regulatory subunit of the PI3K-AKT-mTOR pathway, PIK3R2, in two children with BPP. Of the 38 patients with BPP and normal to large head size who underwent targeted next-generation sequencing by smMIPs, we identified constitutional and mosaic PIK3R2 mutations in 17 additional children. In parallel, one patient had the recurrent PIK3R2 mutation identified by clinical whole-exome sequencing. Seven of these 20 patients had BPP alone, and 13 had BPP in association with features of the

Three-dimensional reactor dynamics code for VVER type nuclear reactors

Energy Technology Data Exchange (ETDEWEB)

Kyrki-Rajamaeki, R. [VTT Energy, Espoo (Finland)

1995-10-01

A three-dimensional reactor dynamics computer code has been developed, validated and applied for transient and accident analyses of VVER type nuclear reactors. This code, HEXTRAN, is a part of the reactor physics and dynamics calculation system of the Technical Research Centre of Finland, VTT. HEXTRAN models accurately the VVER core with hexagonal fuel assemblies. The code uses advanced mathematical methods in spatial and time discretization of neutronics, heat transfer and the two-phase flow equations of hydraulics. It includes all the experience of VTT from 20 years on the accurate three-dimensional static reactor physics as well as on the one-dimensional reactor dynamics. The dynamic coupling with the thermal hydraulic system code SMABRE also allows the VVER circuit-modelling experience to be included in the analyses. (79 refs.).

Three-dimensional reactor dynamics code for VVER type nuclear reactors

International Nuclear Information System (INIS)

Kyrki-Rajamaeki, R.

1995-10-01

A three-dimensional reactor dynamics computer code has been developed, validated and applied for transient and accident analyses of VVER type nuclear reactors. This code, HEXTRAN, is a part of the reactor physics and dynamics calculation system of the Technical Research Centre of Finland, VTT. HEXTRAN models accurately the VVER core with hexagonal fuel assemblies. The code uses advanced mathematical methods in spatial and time discretization of neutronics, heat transfer and the two-phase flow equations of hydraulics. It includes all the experience of VTT from 20 years on the accurate three-dimensional static reactor physics as well as on the one-dimensional reactor dynamics. The dynamic coupling with the thermal hydraulic system code SMABRE also allows the VVER circuit-modelling experience to be included in the analyses. (79 refs.)

78 FR 69139 - Physical Security-Design Certification and Operating Reactors

Science.gov (United States)

2013-11-18

... Operating Reactors AGENCY: Nuclear Regulatory Commission. ACTION: Standard review plan--draft section..., ``Physical Security--Design Certification and Operating Reactors.'' The public comment period was originally....regulations.gov and search for Docket ID NRC-2013-0225. Address questions about NRC dockets to Carol Gallagher...

New applications of neutron noise theory in power reactor physics

Energy Technology Data Exchange (ETDEWEB)

Arzhanov, Vasiliy

2000-04-01

methods that have been developed for traditional reactors and also it poses a number of new problems. As for the latter, the thesis investigates the space-dependent neutron noise caused by a fluctuating source. It is shown that the frequency-dependent spatial behaviour exhibits some new properties that are different from those known in traditional critical systems. On the other hand, various reactor physics approximations (point kinetic, adiabatic etc.) have not been defined yet for subcritical systems. In this respect the thesis presents a systematic formulation of the above mentioned approximations as well as investigations of their properties. By numerical modelling it was found that the applicability of the reactor physics approximations is better than in critical systems. Another interesting problem in neutron noise theory, which recently attracts more and more attention, is the treatment of moving boundaries. In this case one needs to redefine such common methods in reactor physics as point kinetic and adiabatic approximations because, generally speaking, the various functions involved have different regions of definition. The thesis as well presents one possible line of developing the general theory of linear kinetics as applied to systems with varying size. It also generalises the flux factorisation and develops further the Green's function technique.

New applications of neutron noise theory in power reactor physics

International Nuclear Information System (INIS)

Arzhanov, Vasiliy

2000-04-01

methods that have been developed for traditional reactors and also it poses a number of new problems. As for the latter, the thesis investigates the space-dependent neutron noise caused by a fluctuating source. It is shown that the frequency-dependent spatial behaviour exhibits some new properties that are different from those known in traditional critical systems. On the other hand, various reactor physics approximations (point kinetic, adiabatic etc.) have not been defined yet for subcritical systems. In this respect the thesis presents a systematic formulation of the above mentioned approximations as well as investigations of their properties. By numerical modelling it was found that the applicability of the reactor physics approximations is better than in critical systems. Another interesting problem in neutron noise theory, which recently attracts more and more attention, is the treatment of moving boundaries. In this case one needs to redefine such common methods in reactor physics as point kinetic and adiabatic approximations because, generally speaking, the various functions involved have different regions of definition. The thesis as well presents one possible line of developing the general theory of linear kinetics as applied to systems with varying size. It also generalises the flux factorisation and develops further the Green's function technique

Reactor physics activities in France. October 1983 - September 1984

International Nuclear Information System (INIS)

Golinelli, C.; Salvatores, M.

1984-10-01

The major activities of the Fast Reactor Physics Program during the period October 1983 - September 1984 are reviewed: experimental and theoretical studies, computer codes. The LWR program brought improvements in the field of the Advanced Reactors and of the plutonium re-use on French PWRs. Are reviewed experimental studies and facilities, theoretical studies (transport theory, radioactive decay library)

Technical specifications: Health Physics Research Reactor

International Nuclear Information System (INIS)

1979-02-01

The technical specifications define the key limitations that must be observed for safe operation of the Health Physics Research Reactor (HPRR) and an envelope of operation within which there is assurance that these limits will not be exceeded. The specifications were written to satisfy the requirements of the Department of Energy (DOE) Manual Chapter 0540, September 1, 1972

Status of computer codes available in AEOI for reactor physics analysis

International Nuclear Information System (INIS)

Karbassiafshar, M.

1986-01-01

Many of the nuclear computer codes available in Atomic Energy Organization of Iran AEOI can be used for physics analysis of an operating reactor or design purposes. Grasp of the various methods involved and practical experience with these codes would be the starting point for interesting design studies or analysis of operating conditions of presently existing and future reactors. A review of the objectives and flowchart of commonly practiced procedures in reactor physics analysis of LWRs and related computer codes was made, extrapolating to the nationally and internationally available resources. Finally, effective utilization of the existing facilities is discussed and called upon

Standard practice for analysis and interpretation of physics dosimetry results for test reactors

International Nuclear Information System (INIS)

Anon.

1984-01-01

This practice describes the methodology summarized in Annex Al to be used in the analysis and interpretation of physics-dosimetry results from test reactors. This practice relies on, and ties together, the application of several supporting ASTM standard practices, guides, and methods that are in various stages of completion (see Fig. 1). Support subject areas that are discussed include reactor physics calculations, dosimeter selection and analysis, exposure units, and neutron spectrum adjustment methods. This practice is directed towards the development and application of physics-dosimetrymetallurgical data obtained from test reactor irradiation experiments that are performed in support of the operation, licensing, and regulation of LWR nuclear power plants. It specifically addresses the physics-dosimetry aspects of the problem. Procedures related to the analysis, interpretation, and application of both test and power reactor physics-dosimetry-metallurgy results are addressed in Practice E 853, Practice E 560, Matrix E 706(IE), Practice E 185, Matrix E 706(IG), Guide E 900, and Method E 646

Proceedings of the 10. Meeting on Reactor Physics and Thermal Hydraulics

International Nuclear Information System (INIS)

Santos Bastos, W. dos

1995-01-01

These proceedings presents all the Meeting papers emphasizing specific aspects on reactor physics method, criticality, fuel management, nuclear data, safety analysis, simulation and shielding, neutronics, thermal hydraulics, reactor operation and computational methods

PWR surveillance based on correspondence between empirical models and physical

International Nuclear Information System (INIS)

Zwingelstein, G.; Upadhyaya, B.R.; Kerlin, T.W.

1976-01-01

An on line surveillance method based on the correspondence between empirical models and physicals models is proposed for pressurized water reactors. Two types of empirical models are considered as well as the mathematical models defining the correspondence between the physical and empirical parameters. The efficiency of this method is illustrated for the surveillance of the Doppler coefficient for Oconee I (an 886 MWe PWR) [fr

Breast Cancer Heterogeneity Examined by High-Sensitivity Quantification of PIK3CA, KRAS, HRAS, and BRAF Mutations in Normal Breast and Ductal Carcinomas

Directory of Open Access Journals (Sweden)

Meagan B. Myers

2016-04-01

Full Text Available Mutant cancer subpopulations have the potential to derail durable patient responses to molecularly targeted cancer therapeutics, yet the prevalence and size of such subpopulations are largely unexplored. We employed the sensitive and quantitative Allele-specific Competitive Blocker PCR approach to characterize mutant cancer subpopulations in ductal carcinomas (DCs, examining five specific hotspot point mutations (PIK3CA H1047R, KRAS G12D, KRAS G12V, HRAS G12D, and BRAF V600E. As an approach to aid interpretation of the DC results, the mutations were also quantified in normal breast tissue. Overall, the mutations were prevalent in normal breast and DCs, with 9/9 DCs having measureable levels of at least three of the five mutations. HRAS G12D was significantly increased in DCs as compared to normal breast. The most frequent point mutation reported in DC by DNA sequencing, PIK3CA H1047R, was detected in all normal breast tissue and DC samples and was present at remarkably high levels (mutant fractions of 1.1 × 10−3 to 4.6 × 10−2 in 4/10 normal breast samples. In normal breast tissue samples, PIK3CA mutation levels were positively correlated with age. However, the PIK3CA H1047R mutant fraction distributions for normal breast tissues and DCs were similar. The results suggest PIK3CA H1047R mutant cells have a selective advantage in breast, contribute to breast cancer susceptibility, and drive tumor progression during breast carcinogenesis, even when present as only a subpopulation of tumor cells.

Advanced multi-physics simulation capability for very high temperature reactors

International Nuclear Information System (INIS)

Lee, Hyun Chul; Tak, Nam Il; Jo Chang Keun; Noh, Jae Man; Cho, Bong Hyun; Cho, Jin Woung; Hong, Ser Gi

2012-01-01

The purpose of this research is to develop methodologies and computer code for high-fidelity multi-physics analysis of very high temperature gas-cooled reactors(VHTRs). The research project was performed through Korea-US I-NERI program. The main research topic was development of methodologies for high-fidelity 3-D whole core transport calculation, development of DeCART code for VHTR reactor physics analysis, generation of VHTR specific 190-group cross-section library for DeCART code, development of DeCART/CORONA coupled code system for neutronics/thermo-fluid multi-physics analysis, and benchmark analysis against various benchmark problems derived from PMR200 reactor. The methodologies and the code systems will be utilized a key technologies in the Nuclear Hydrogen Development and Demonstration program. Export of code system is expected in the near future and the code systems developed in this project are expected to contribute to development and export of nuclear hydrogen production system

Modeling and performance of the MHTGR [Modular High-Temperature Gas-Cooled Reactor] reactor cavity cooling system

International Nuclear Information System (INIS)

Conklin, J.C.

1990-04-01

The Reactor Cavity Cooling System (RCCS) of the Modular High- Temperature Gas-Cooled Reactor (MHTGR) proposed by the U.S. Department of Energy is designed to remove the nuclear afterheat passively in the event that neither the heat transport system nor the shutdown cooling circulator subsystem is available. A computer dynamic simulation for the physical and mathematical modeling of and RCCS is described here. Two conclusions can be made form computations performed under the assumption of a uniform reactor vessel temperature. First, the heat transferred across the annulus from the reactor vessel and then to ambient conditions is very dependent on the surface emissivities of the reactor vessel and RCCS panels. These emissivities should be periodically checked to ensure the safety function of the RCCS. Second, the heat transfer from the reactor vessel is reduced by a maximum of 10% by the presence of steam at 1 atm in the reactor cavity annulus for an assumed constant in the transmission of radiant energy across the annulus can be expected to result in an increase in the reactor vessel temperature for the MHTGR. Further investigation of participating radiation media, including small particles, in the reactor cavity annulus is warranted. 26 refs., 7 figs., 1 tab

Robust observer based control for axial offset in pressurized-water nuclear reactors based on the multipoint reactor model using Lyapunov approach

Energy Technology Data Exchange (ETDEWEB)

Zaidabadinejad, Majid; Ansarifar, Gholam Reza [Isfahan Univ. (Iran, Islamic Republic of). Dept. of Nuclear Engineering

2017-11-15

In nuclear reactor imbalance of axial power distribution induces xenon oscillations. These fluctuations must be maintained bounded within allowable limits. Otherwise, the nuclear power plant could become unstable. Therefore, bounded these oscillations is considered to be a restriction for the load following operation. Also, in order to design the nuclear reactor control systems, poisons concentrations, especially xenon must be accessible. But, physical measurement of these parameters is impossible. In this paper, for the first time, in order to estimate the axial xenon oscillations and ensures these oscillations are kept bounded within allowable limits during load-following operation, a robust observer based nonlinear control based on multipoint kinetics reactor model for pressurized-water nuclear reactors is presented. The reactor core is simulated based on the multi-point nuclear reactor model (neutronic and thermal-hydraulic). Simulation results are presented to demonstrate the effectiveness of the proposed observer based controller for the load-following operation.

Robust observer based control for axial offset in pressurized-water nuclear reactors based on the multipoint reactor model using Lyapunov approach

International Nuclear Information System (INIS)

Zaidabadinejad, Majid; Ansarifar, Gholam Reza

2017-01-01

In nuclear reactor imbalance of axial power distribution induces xenon oscillations. These fluctuations must be maintained bounded within allowable limits. Otherwise, the nuclear power plant could become unstable. Therefore, bounded these oscillations is considered to be a restriction for the load following operation. Also, in order to design the nuclear reactor control systems, poisons concentrations, especially xenon must be accessible. But, physical measurement of these parameters is impossible. In this paper, for the first time, in order to estimate the axial xenon oscillations and ensures these oscillations are kept bounded within allowable limits during load-following operation, a robust observer based nonlinear control based on multipoint kinetics reactor model for pressurized-water nuclear reactors is presented. The reactor core is simulated based on the multi-point nuclear reactor model (neutronic and thermal-hydraulic). Simulation results are presented to demonstrate the effectiveness of the proposed observer based controller for the load-following operation.

Reactor physics calculations on HTR type configurations

Energy Technology Data Exchange (ETDEWEB)

Klippel, H.T.; Hogenbirk, A.; Stad, R.C.L. van der; Janssen, A.J.; Kuijper, J.C.; Levin, P.

1995-04-01

In this paper a short description of the ECN nuclear analysis code system is given with respect to application in HTR reactor physics calculations. First results of calculations performed on the PROTEUS benchmark are shown. Also first results of a HTGR benchmark are given. (orig.).

Reactor physics calculations on HTR type configurations

International Nuclear Information System (INIS)

Klippel, H.T.; Hogenbirk, A.; Stad, R.C.L. van der; Janssen, A.J.; Kuijper, J.C.; Levin, P.

1995-04-01

In this paper a short description of the ECN nuclear analysis code system is given with respect to application in HTR reactor physics calculations. First results of calculations performed on the PROTEUS benchmark are shown. Also first results of a HTGR benchmark are given. (orig.)

Sources of radioactive waste from light-water reactors and their physical and chemical properties

International Nuclear Information System (INIS)

Bell, M.J.; Collins, J.T.

1979-01-01

The general physical and chemical properties of waste streams in light-water reactors (LWRs) are described. The principal mechanisms for release and the release pathways to the environment are discussed. The calculation of liquid and gaseous source terms using one of the available models is presented. These calculated releases are compared with observed releases from operating LWRs. The computerized mathematical model used is the GALE Code which is the Nuclear Regulatory Commission (NRC) staff's model for calculating source terms for effluents from LWRs (USNRC76a, USNRC76b). Programs currently being conducted at operating reactors by the NRC, Electric Power Research Institute, and various utilities to better define the characteristics of waste streams and the performance of radwaste process equipment are described

Validation of the dynamic model for a pressurized water reactor

International Nuclear Information System (INIS)

Zwingelstein, Gilles.

1979-01-01

Dynamic model validation is a necessary procedure to assure that the developed empirical or physical models are satisfactorily representing the dynamic behavior of the actual plant during normal or abnormal transients. For small transients, physical models which represent isolated core, isolated steam generator and the overall pressurized water reactor are described. Using data collected during the step power changes that occured during the startup procedures, comparisons of experimental and actual transients are given at 30% and 100% of full power. The agreement between the transients derived from the model and those recorded on the plant indicates that the developed models are well suited for use for functional or control studies

Calculation models for a nuclear reactor

International Nuclear Information System (INIS)

Tashanii, Ahmed Ali

2010-01-01

Determination of different parameters of nuclear reactors requires neutron transport calculations. Due to complicity of geometry and material composition of the reactor core, neutron calculations were performed for simplified models of the real arrangement. In frame of the present work two models were used for calculations. First, an elementary cell model was used to prepare cross section data set for a homogenized-core reactor model. The homogenized-core reactor model was then used to perform neutron transport calculation. The nuclear reactor is a tank-shaped thermal reactor. The semi-cylindrical core arrangement consists of aluminum made fuel bundles immersed in water which acts as a moderator as well as a coolant. Each fuel bundle consists of aluminum cladded fuel rods arranged in square lattices. (author)

Summary of ORSphere Critical and Reactor Physics Measurements

Energy Technology Data Exchange (ETDEWEB)

Marshall, Margaret A.; Bess, John D.

2016-09-01

In the early 1970s Dr. John T. Mihalczo (team leader), J. J. Lynn, and J. R. Taylor performed experiments at the Oak Ridge Critical Experiments Facility (ORCEF) with highly enriched uranium (HEU) metal (called Oak Ridge Alloy or ORALLOY) to recreate GODIVA I results with greater accuracy than those performed at Los Alamos National Laboratory in the 1950s. The purpose of the Oak Ridge ORALLOY Sphere (ORSphere) experiments was to estimate the unreflected and unmoderated critical mass of an idealized sphere of uranium metal corrected to a density, purity, and enrichment such that it could be compared with the GODIVA I experiments. This critical configuration has been evaluated. Preliminary results were presented at ND2013. Since then, the evaluation was finalized and judged to be an acceptable benchmark experiment for the International Criticality Safety Benchmark Experiment Project (ICSBEP). Additionally, reactor physics measurements were performed to determine surface button worths, central void worth, delayed neutron fraction, prompt neutron decay constant, fission density and neutron importance. These measurements have been evaluated and found to be acceptable experiments and are discussed in full detail in the International Handbook of Evaluated Reactor Physics Benchmark Experiments. The purpose of this paper is summary summarize all the critical and reactor physics measurements evaluations and, when possible, to compare them to GODIVA experiment results.

A model for a countercurrent gas—solid—solid trickle flow reactor for equilibrium reactions. The methanol synthesis

NARCIS (Netherlands)

Westerterp, K.R.; Kuczynski, M.

1987-01-01

The theoretical background for a novel, countercurrent gas—solid—solid trickle flow reactor for equilibrium gas reactions is presented. A one-dimensional, steady-state reactor model is developed. The influence of the various process parameters on the reactor performance is discussed. The physical

Physics of plutonium recycling: volume V. Plutonium recycling in fast reactors

International Nuclear Information System (INIS)

1996-01-01

As part of a programme proposed by the OECD/NEA Working Party on Physics of Plutonium Recycling (WPPR) to evaluate different scenarios for the use of plutonium, fast reactor physics benchmarks were developed. In this report, the multi-recycle performance of the metal-fuelled benchmark is evaluated. Benchmark results assess the reactor performance and toxicity behaviour in a closed nuclear fuel cycle for a parametric variation of the conversion ratio between 0.5 and 1.0. Results indicate that a fast burner reactor closed fuel cycle can be utilised to significantly reduce the radiotoxicity originating in the LWR cycle which would otherwise be destined for burial. (Author). tabs., figs., refs

SILOETTE, a training centre for reactor physics at the Nuclear Research Centre of Grenoble

International Nuclear Information System (INIS)

Destot, M.

1983-10-01

The Reactor Department of Grenoble has created, based on Siloette, an activity of training in reactor physics, wich is running since 1975 to meet the important needs generated by the development of electronuclear power stations. Its essential goal is to provide an initiation to the basic physical phenomena which determine the operation of the reactors. For that purpose, a rather comprehensive program of practical works on reactor (SILOETTE) and on nuclear power station simulators (PWR, UNGG) is proposed besides lectures and conferences, general and specialized teaching on the reactor operation principle, kinetics, dynamics and thermics

Physics of Fast and Intermediate Reactors. V. I. Proceedings of the Seminar on the Physics of Fast and Intermediate Reactors. V. I

Energy Technology Data Exchange (ETDEWEB)

NONE

1962-03-15

It is generally agreed that the ultimate economic advantage of power produced by nuclear fission over that produced by conventional sources depends on the ability of a certain type of reactor to breed precious nuclear fuel out of the plentiful but not readily fissionable isotope of uranium. This fact is mainly responsible for the importance attached to the development of fast power reactors, but many other interesting properties of unmoderated or weakly moderated reactor systems have also been brought to light by reactor physicists. In August 1961 the Agency organized in Vienna a Seminar on the Physics of Past and Intermediate Reactors, at which all the topics relating to this important branch, of reactor science were discussed. The main feature of this meeting was extensive discussion of the 66 written contributions, which set the stage for a wide exchange of experience and ideas throughout 13 half-day sessions. The Seminar was attended by 132 scientists from 22 Member States and two international organizations. It is hoped that these Proceedings of the Seminar, which include both the papers presented and a record of the discussions, will be useful as a reference work both to research workers in the field and to newcomers to it for many years to come. The Agency's thanks are due to all the participating scientists for their written or oral contributions and especially to those among them who, as session chairmen, led the discussions and contributed greatly to the success of the meeting. During the Seminar, sixty-five papers were orally presented, and seven more were accepted for publication in the Proceedings. In order that these Proceedings might be in the hands of their users at an early date, the method of presentation of the papers and of the extensive session discussions had to be somewhat different from the one usually followed. The complete record of the sessions will be found at the end of Volume III. The order in which the papers are presented here is not

International Thermonuclear Experimental Reactor: Physics issues, capabilities and physics program plans

International Nuclear Information System (INIS)

Wesley, J.C.

1997-01-01

Present status and understanding of the principal plasma-performance determining physics issues that affect the physics design and operational capabilities of the International Thermonuclear Experimental Reactor (ITER) [ITER EDA Agreement and Protocol 2 (International Atomic Energy Agency, Vienna, 1994)] are presented. Emphasis is placed on the five major physics-basis issues emdash energy confinement, beta limit, density limit, impurity dilution and radiation loss, and the feasibility of obtaining partial-detached divertor operation emdash that directly affect projections of ITER fusion power and burn duration performance. A summary of these projections is presented and the effect of uncertainties in the physics-basis issues is examined. ITER capabilities for experimental flexibility and plasma-performance optimization are also described, and how these capabilities may enter into the ITER physics program plan is discussed. copyright 1997 American Institute of Physics

Reactor physics verification of the MCNP6 unstructured mesh capability

International Nuclear Information System (INIS)

Burke, T. P.; Kiedrowski, B. C.; Martz, R. L.; Martin, W. R.

2013-01-01

The Monte Carlo software package MCNP6 has the ability to transport particles on unstructured meshes generated from the Computed-Aided Engineering software Abaqus. Verification is performed using benchmarks with features relevant to reactor physics - Big Ten and the C5G7 computational benchmark. Various meshing strategies are tested and results are compared to reference solutions. Computational performance results are also given. The conclusions show MCNP6 is capable of producing accurate calculations for reactor physics geometries and the computational requirements for small lattice benchmarks are reasonable on modern computing platforms. (authors)

Reactor physics verification of the MCNP6 unstructured mesh capability

Energy Technology Data Exchange (ETDEWEB)

Burke, T. P. [Department of Nuclear Engineering and Radiological Sciences, University of Michigan, 2355 Bonisteel Boulevard, Ann Arbor, MI 48109 (United States); Kiedrowski, B. C.; Martz, R. L. [X-Computational Physics Division, Monte Carlo Codes Group, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545 (United States); Martin, W. R. [Department of Nuclear Engineering and Radiological Sciences, University of Michigan, 2355 Bonisteel Boulevard, Ann Arbor, MI 48109 (United States)

2013-07-01

The Monte Carlo software package MCNP6 has the ability to transport particles on unstructured meshes generated from the Computed-Aided Engineering software Abaqus. Verification is performed using benchmarks with features relevant to reactor physics - Big Ten and the C5G7 computational benchmark. Various meshing strategies are tested and results are compared to reference solutions. Computational performance results are also given. The conclusions show MCNP6 is capable of producing accurate calculations for reactor physics geometries and the computational requirements for small lattice benchmarks are reasonable on modern computing platforms. (authors)

An optimization method for parameters in reactor nuclear physics

International Nuclear Information System (INIS)

Jachic, J.

1982-01-01

An optimization method for two basic problems of Reactor Physics was developed. The first is the optimization of a plutonium critical mass and the bruding ratio for fast reactors in function of the radial enrichment distribution of the fuel used as control parameter. The second is the maximization of the generation and the plutonium burnup by an optimization of power temporal distribution. (E.G.) [pt

WWER reactor physics code applications

International Nuclear Information System (INIS)

Gado, J.; Kereszturi, A.; Gacs, A.; Telbisz, M.

1994-01-01

The coupled steady-state reactor physics and thermohydraulic code system KARATE has been developed and applied for WWER-1000 and WWER-440 operational calculations. The 3 D coupled kinetic code KIKO3D has been developed and validated for WWER-440 accident analysis applications. The coupled kinetic code SMARTA developed by VTT Helsinki has been applied for WWER-440 accident analysis. The paper gives a summary of the experience in code development and application. (authors). 10 refs., 2 tabs., 5 figs

Multimedia on nuclear reactors physics

International Nuclear Information System (INIS)

Dies, Javier; Puig, Francesc

2010-01-01

The paper present an example of measures that have been found to be effective in the development of innovative educational and training technology. A multimedia course on nuclear reactor physics is presented. This material has been used for courses at master level at the universities; training for engineers at nuclear power plant as modular 2 weeks course; and training operators of nuclear power plant. The multimedia has about 785 slides and the text is in English, Spanish and French. (authors)

Current Reactor Physics Benchmark Activities at the Idaho National Laboratory

International Nuclear Information System (INIS)

Bess, John D.; Marshall, Margaret A.; Gorham, Mackenzie L.; Christensen, Joseph; Turnbull, James C.; Clark, Kim

2011-01-01

The International Reactor Physics Experiment Evaluation Project (IRPhEP) (1) and the International Criticality Safety Benchmark Evaluation Project (ICSBEP) (2) were established to preserve integral reactor physics and criticality experiment data for present and future research. These valuable assets provide the basis for recording, developing, and validating our integral nuclear data, and experimental and computational methods. These projects are managed through the Idaho National Laboratory (INL) and the Organisation for Economic Co-operation and Development Nuclear Energy Agency (OECD-NEA). Staff and students at the Department of Energy - Idaho (DOE-ID) and INL are engaged in the development of benchmarks to support ongoing research activities. These benchmarks include reactors or assemblies that support Next Generation Nuclear Plant (NGNP) research, space nuclear Fission Surface Power System (FSPS) design validation, and currently operational facilities in Southeastern Idaho.

Characterization of mutations of the phosphoinositide-3-kinase regulatory subunit, PIK3R2, in perisylvian polymicrogyria: a next generation sequencing study

Science.gov (United States)

Mirzaa, Ghayda; Conti, Valerio; Timms, Andrew E.; Smyser, Christopher D.; Ahmed, Sarah; Carter, Melissa; Barnett, Sarah; Hufnagel, Robert B.; Goldstein, Amy; Narumi-Kishimoto, Yoko; Olds, Carissa; Collins, Sarah; Johnston, Kathreen; Deleuze, Jean-François; Nitschké, Patrick; Friend, Kathryn; Harris, Catharine; Goetsch, Allison; Martin, Beth; Boyle, Evan August; Parrini, Elena; Mei, Davide; Tattini, Lorenzo; Slavotinek, Anne; Blair, Ed; Barnett, Christopher; Shendure, Jay; Chelly, Jamel; Dobyns, William B.; Guerrini, Renzo

2015-01-01

SUMMARY Background Bilateral perisylvian polymicrogyria (BPP), the most common form of regional polymicrogyria, causes the congenital bilateral perisylvian syndrome, featuring oromotor dysfunction, cognitive impairment and epilepsy. BPP is etiologically heterogeneous, but only a few genetic causes have been reported. The aim of this study was to identify additional genetic etiologies of BPP and delineate their frequency in this patient population. Methods We performed child-parent (trio)-based whole exome sequencing (WES) on eight children with BPP. Following the identification of mosaic PIK3R2 mutations in two of these eight children, we performed targeted screening of PIK3R2 in a cohort of 118 children with BPP who were ascertained from 1980 until 2015 using two methods. First, we performed targeted sequencing of the entire PIK3R2 gene by single molecule molecular inversion probes (smMIPs) on 38 patients with BPP with normal-large head size. Second, we performed amplicon sequencing of the recurrent PIK3R2 mutation (p.Gly373Arg) on 80 children with various types of polymicrogyria including BPP. One additional patient underwent clinical WES independently, and was included in this study given the phenotypic similarity to our cohort. All patients included in this study were children (BPP. Of the 38 patients with BPP and normal-large head size who underwent targeted next generation sequencing by smMIPs, we identified constitutional and mosaic PIK3R2 mutations in 17 additional children. In parallel, one patient was found to have the recurrent PIK3R2 mutation by clinical WES. Seven patients had BPP alone, and 13 had BPP in association with features of the megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome (MPPH). Nineteen patients had the same mutation (Gly373Arg), and one had a nearby missense mutation (p.Lys376Glu). Across the entire cohort, mutations were constitutional in 12 and mosaic in eight patients. Among mosaic patients, we observed substantial

Research on reactor physics using the Very High Temperature Reactor Critical Assembly (VHTRC)

International Nuclear Information System (INIS)

Akino, Fujiyoshi

1988-01-01

The High Temperature Engineering Test Reactor (HTTR), of which the research and development are advanced by Japan Atomic Energy Research Institute, is planned to apply for the permission of installation in fiscal year 1988, and to start the construction in the latter half of fisical year 1989. As the duty of reactor physics research, the accuracy of the nuclear data is to be confirmed, the validity of the nuclear design techniques is to be inspected, and the nuclear safety of the HTTR core design is to be verified. Therefore, by using the VHTRC, the experimental data of the reactor physics quantities are acquired, such as critical mass, the reactivity worth of simulated control rods and burnable poison rods, the temperature factor of reactivity, power distribution and so on, and the experiment and analysis are advanced. The cores built up in the VHTRC so far were three kinds having different lattice forms and degrees of uranium enrichment. The calculated critical mass was smaller by 1-5 % than the measured values. As to the power distribution and the reactivity worth of burnable poison rods, the prospect of satisfying the required accuracy for the design of the HTTR core was obtained. The experiment using a new core having axially different enrichment degree is planned. (K.I.)

Coarse mesh finite element method for boiling water reactor physics analysis

International Nuclear Information System (INIS)

Ellison, P.G.

1983-01-01

A coarse mesh method is formulated for the solution of Boiling Water Reactor physics problems using two group diffusion theory. No fuel assembly cross-section homogenization is required; water gaps, control blades and fuel pins of varying enrichments are treated explicitly. The method combines constrained finite element discretization with infinite lattice super cell trial functions to obtain coarse mesh solutions for which the only approximations are along the boundaries between fuel assemblies. The method is applied to bench mark Boiling Water Reactor problems to obtain both the eigenvalue and detailed flux distributions. The solutions to these problems indicate the method is useful in predicting detailed power distributions and eigenvalues for Boiling Water Reactor physics problems

PRKCI negatively regulates autophagy via PIK3CA/AKT–MTOR signaling

Energy Technology Data Exchange (ETDEWEB)

Qu, Liujing; Li, Ge; Xia, Dan; Hongdu, Beiqi; Xu, Chentong; Lin, Xin [Key Laboratory of Medical Immunology, Ministry of Health, Peking University Health Sciences Center, Beijing (China); Peking University Center for Human Disease Genomics, Peking University, Beijing (China); Chen, Yingyu, E-mail: yingyu_chen@bjmu.edu.cn [Key Laboratory of Medical Immunology, Ministry of Health, Peking University Health Sciences Center, Beijing (China); Peking University Center for Human Disease Genomics, Peking University, Beijing (China)

2016-02-05

The atypical protein kinase C isoform PRKC iota (PRKCI) plays a key role in cell proliferation, differentiation, and carcinogenesis, and it has been shown to be a human oncogene. Here, we show that PRKCI overexpression in U2OS cells impaired functional autophagy in normal or cell stress conditions, as characterized by decreased levels of light chain 3B-II protein (LC3B-II) and weakened degradation of endogenous and exogenous autophagic substrates. Conversely, PRKCI knockdown by small interference RNA resulted in opposite effects. Additionally, we identified two novel PRKCI mutants, PRKCI{sup L485M} and PRKCI{sup P560R}, which induced autophagy and exhibited dominant negative effects. Further studies indicated that PRKCI knockdown–mediated autophagy was associated with the inactivation of phosphatidylinositol 3-kinase alpha/AKT–mammalian target of rapamycin (PIK3CA/AKT–MTOR) signaling. These data underscore the importance of PRKCI in the regulation of autophagy. Moreover, the finding may be useful in treating PRKCI-overexpressing carcinomas that are characterized by increased levels of autophagy. - Highlights: • The atypical protein kinase C iota isoform (PRKCI) is a human oncogene. • PRKCI overexpression impairs functional autophagy in U2OS cells. • It reduces LC3B-II levels and weakens SQSTM1 and polyQ80 aggregate degradation. • PRKCI knockdown has the opposite effect. • The effect of PRKCI knockdown is related to PIK3CA/AKT–MTOR signaling inactivation.

Activity report of working party on reactor physics of subcritical system. October 2001 to March 2003

International Nuclear Information System (INIS)

2004-03-01

Under the Research Committee on Reactor Physics, the Working Party on Reactor Physics of Subcritical System (ADS-WP) was set in July 2001 to research reactor physics of subcritical system such as Accelerator-Driven System (ADS). The WP, at the first meeting, discussed a guideline of its activity for two years and decided to perform theoretical research for the following subjects: (1) study of reactor physics for a subcritical core, (2) benchmark problems for a subcritical core and their calculations, (3) study of physical parameters affecting to set subcriticality of ADS, and (4) study of measurement and surveillance methods of subcriticality of a subcritical core. The activity of ADS-WP continued up to March 2003. In this duration, the members of the WP met together eight times, including four meetings jointly held with the Workshop on Accelerator-Driven Subcritical Reactor at Kyoto University Research Reactor Institute. This report summarizes the result obtained by the above WP activity and research. (author)

Physically - engineering problems of the Salaspils Nuclear reactor: Solutions and their topicality

International Nuclear Information System (INIS)

Mozgirs, Z.V.

2005-01-01

The paper generalizes technical solutions of physically-engineering problems of the Salaspils nuclear research reactor, experience of its modernization and exploitation. New equipment and the related technical solutions have been tested at the Salaspils reactor during its operation time and are now recommended for further use at nuclear reactors. (author)

Monte Carlo modelling of TRIGA research reactor

Science.gov (United States)

El Bakkari, B.; Nacir, B.; El Bardouni, T.; El Younoussi, C.; Merroun, O.; Htet, A.; Boulaich, Y.; Zoubair, M.; Boukhal, H.; Chakir, M.

2010-10-01

The Moroccan 2 MW TRIGA MARK II research reactor at Centre des Etudes Nucléaires de la Maâmora (CENM) achieved initial criticality on May 2, 2007. The reactor is designed to effectively implement the various fields of basic nuclear research, manpower training, and production of radioisotopes for their use in agriculture, industry, and medicine. This study deals with the neutronic analysis of the 2-MW TRIGA MARK II research reactor at CENM and validation of the results by comparisons with the experimental, operational, and available final safety analysis report (FSAR) values. The study was prepared in collaboration between the Laboratory of Radiation and Nuclear Systems (ERSN-LMR) from Faculty of Sciences of Tetuan (Morocco) and CENM. The 3-D continuous energy Monte Carlo code MCNP (version 5) was used to develop a versatile and accurate full model of the TRIGA core. The model represents in detailed all components of the core with literally no physical approximation. Continuous energy cross-section data from the more recent nuclear data evaluations (ENDF/B-VI.8, ENDF/B-VII.0, JEFF-3.1, and JENDL-3.3) as well as S( α, β) thermal neutron scattering functions distributed with the MCNP code were used. The cross-section libraries were generated by using the NJOY99 system updated to its more recent patch file "up259". The consistency and accuracy of both the Monte Carlo simulation and neutron transport physics were established by benchmarking the TRIGA experiments. Core excess reactivity, total and integral control rods worth as well as power peaking factors were used in the validation process. Results of calculations are analysed and discussed.

Yale High Energy Physics Research: Precision Studies of Reactor Antineutrinos

International Nuclear Information System (INIS)

Heeger, Karsten M.

2014-01-01

This report presents experimental research at the intensity frontier of particle physics with particular focus on the study of reactor antineutrinos and the precision measurement of neutrino oscillations. The experimental neutrino physics group of Professor Heeger and Senior Scientist Band at Yale University has had leading responsibilities in the construction and operation of the Daya Bay Reactor Antineutrino Experiment and made critical contributions to the discovery of non-zero$\\theta . Heeger and Band led the Daya Bay detector management team and are now overseeing the operations of the antineutrino detectors. Postdoctoral researchers and students in this group have made leading contributions to the Daya Bay analysis including the prediction of the reactor antineutrino flux and spectrum, the analysis of the oscillation signal, and the precision determination of the target mass yielding unprecedented precision in the relative detector uncertainty. Heeger's group is now leading an R\\&D effort towards a short-baseline oscillation experiment, called PROSPECT, at a US research reactor and the development of antineutrino detectors with advanced background discrimination.

Yale High Energy Physics Research: Precision Studies of Reactor Antineutrinos

Energy Technology Data Exchange (ETDEWEB)

Heeger, Karsten M. [Yale Univ., New Haven, CT (United States)

2014-09-13

This report presents experimental research at the intensity frontier of particle physics with particular focus on the study of reactor antineutrinos and the precision measurement of neutrino oscillations. The experimental neutrino physics group of Professor Heeger and Senior Scientist Band at Yale University has had leading responsibilities in the construction and operation of the Daya Bay Reactor Antineutrino Experiment and made critical contributions to the discovery of non-zero$\\theta_{13}$. Heeger and Band led the Daya Bay detector management team and are now overseeing the operations of the antineutrino detectors. Postdoctoral researchers and students in this group have made leading contributions to the Daya Bay analysis including the prediction of the reactor antineutrino flux and spectrum, the analysis of the oscillation signal, and the precision determination of the target mass yielding unprecedented precision in the relative detector uncertainty. Heeger's group is now leading an R\\&D effort towards a short-baseline oscillation experiment, called PROSPECT, at a US research reactor and the development of antineutrino detectors with advanced background discrimination.

IRPhE - International Reactor Physics Experiments database

International Nuclear Information System (INIS)

Sartori, E.

2004-01-01

The OECD/NEA Nuclear Science Committee (NSC) has identified the need to establish international databases containing all the important experiments that are available for sharing among the specialists and has set up or sponsored specific activities to achieve this. The aim is to preserve them in an agreed standard format in computer accessible form, to use them for international activities involving validation of current and new calculational schemes including computer codes and nuclear data libraries, for assessing uncertainties, confidence bounds and safety margins, and to record measurement methods and techniques. It is a significant saving results from disseminating a standard benchmark set to be used worldwide. A framework for professionals that use the standard benchmark set to validate and verify modeling codes and data for radiation transport, criticality safety and reactor physics applications guarantees a comparative set of analyses. It represents also a good basis for pinpointing important gaps and where efforts should be concentrated and ensures knowledge and competence preservation, management and transfer in nuclear science and engineering. A large number of experimentalists, physicists, evaluators, modelers have devoted large amounts of their efforts and competencies to produce the data on which the methods we are using today are based. These data are far from having been exploited fully for the different nuclear and radiation technologies. This wealth of information needs to be preserved in a form more easily exploitable by modern information technology and for use in connection with novel and refined computational models with limitations of the past removed. These data will form the basis for the studies of more advanced nuclear technology, will be instrumental in identifying areas where there is a lack of knowledge and thus provide support to justifying new experiments that would reduce design uncertainties and consequently costs. Improvement of

Neutron physics of a high converting advanced pressurized water reactor

International Nuclear Information System (INIS)

Berger, H.D.

1985-01-01

The neutron physics of an APWR are analysed by single pin-cell calculations as well as two-dimensional whole-reactor computations. The calculational methods of the two codes employed for this study, viz. the cell code SPEKTRA and the diffusion-burnup code DIBU, are presented in detail. The APWR-investigations carried out concentrate on the void coefficient characteristics of tight UO 2 /PuO 2 -lattices, control rod worths, burnup behaviour and spatial power distributions in APWR cores. The principal physics design differences between advanced pressurized water reactors and present-day PWRs are identified and discussed. (orig./HP) [de

Fusion reactors: physics and technology. Annual progress report

International Nuclear Information System (INIS)

Conn, R.W.

1983-08-01

Fusion reactors are designed to operate at full power and generally at steady state. Yet experience shows the load variations, licensing constraints, and frequent sub-system failures often require a plant to operate at fractions of rated power. The aim of this study has been to assess the technology problems and design implications of startup and fractional power operation on fusion reactors. The focus of attention has been tandem mirror reactors (TMR) and we have concentrated on the plasma and blanket engineering for startup and fractional power operation. In this report, we first discuss overall problems of startup, shutdown and staged power operation and their influence on TMR design. We then present a detailed discussion of the plasma physics associated with TMR startup and various means of achieving staged power operation. We then turn to the issue of instrumentation and safety controls for fusion reactors. Finally we discuss the limits on transient power variations during startup and shutdown of Li 17 Pb 83 cooled blankets

HTGR reactor physics, thermal-hydraulics and depletion uncertainty analysis: a proposed IAEA coordinated research project

International Nuclear Information System (INIS)

Tyobeka, Bismark; Reitsma, Frederik; Ivanov, Kostadin

2011-01-01

The continued development of High Temperature Gas Cooled Reactors (HTGRs) requires verification of HTGR design and safety features with reliable high fidelity physics models and robust, efficient, and accurate codes. The predictive capability of coupled neutronics/thermal hydraulics and depletion simulations for reactor design and safety analysis can be assessed with sensitivity analysis and uncertainty analysis methods. In order to benefit from recent advances in modeling and simulation and the availability of new covariance data (nuclear data uncertainties) extensive sensitivity and uncertainty studies are needed for quantification of the impact of different sources of uncertainties on the design and safety parameters of HTGRs. Uncertainty and sensitivity studies are an essential component of any significant effort in data and simulation improvement. In February 2009, the Technical Working Group on Gas-Cooled Reactors recommended that the proposed IAEA Coordinated Research Project (CRP) on the HTGR Uncertainty Analysis in Modeling be implemented. In the paper the current status and plan are presented. The CRP will also benefit from interactions with the currently ongoing OECD/NEA Light Water Reactor (LWR) UAM benchmark activity by taking into consideration the peculiarities of HTGR designs and simulation requirements. (author)

International Conference on Physics and Technology of Reactors and Applications

International Nuclear Information System (INIS)

2011-01-01

Full text : The international conference on physics and technology of reactors is organized by the Moroccan Association for Nuclear enggineering and Reactor Technology (GMTR) with the collaboration of the Centre for Energy and Nuclear Sciences and Techniques (CNESTEN) and under the auspices of the ministry of Energy, Mining, Water and Environment. The programme of the PHYTRA2 conference covers a wide variety of topics. The conference is organised in one plenary session, eight oral technical sessions and one poster session. The oral and poster technical sessions covers the usual topics of nuclear engineering including one session on research reactors utilisation and computational methods for research reactors

Nuclear engineering laboratory self regulated power oscillation experiments at the Health Physics Research Reactor

International Nuclear Information System (INIS)

Miller, L.F.; Mihalczo, J.T.; Bailiff, E.G.; Woody, N.D.; Gardner, G.D.

1983-01-01

Self regulated power oscillation experiments with a variety of initial conditions have been performed with the ORNL Health Physics Research Reactor (HPRR) by undergraduate nuclear engineering students from The University of Tennessee for several years. These experiments demonstrate the coupling between reactor kinetics and heat transfer and show how the temperature coefficient of reactivity affects reactor behavior. A model that consists of several coupled first order nonlinear differential equations is used to calculate the temperature of the core center and surface and power as a function of time which are compared with the experimental data; also, the model is also used to study the effects of various model parameters and initial conditions on the amplitude, frequency and damping of the power and temperature oscillations. A previous paper presented some limited experimental results and demonstrated the correspondence between a simple point model and the experimental data. This paper presents the results of experiments for: (1) the initial power fixed at 9 kW with central core temperatures of 300 0 F and 500 0 F, annd (2) the initial central core temperature fixed at 500 0 F with initial powers of 6 and 8 kW

The review of the reactor physics experiments carried out on the LR-0 research reactor NRI Rez plc for reactors of the VVER type

International Nuclear Information System (INIS)

Hudec, Frantisek; Jansky, Bohumil; Juricek, Vlastimil; Mikus, Jan; Novak, Evzen; Osmera, Bohumil; Posta, Severin; Rypar, Vojtech; Svadlenkova, Marie

2010-01-01

LR-0 is an experimental zero power reactor mainly used for the determination of the neutron-physical characteristics of WWER and PWR type reactor lattices and shielding with UO2 or MOX fuel. Its major assets include capability to design and operate multizone cores, i.e. substituted cores, with an inner inserted part in hexagonal or square geometry (driven by LR-0 standard assemblies); Standard and special supporting plates for mock-up experiments; special supporting plates, which enables the triangular symmetrical assembly arrangement with an arbitrary pitch; Modeling neutron field parameters of power reactors; Wide range benchmarking possibilities, with high reproducibility of the benchmark design parameters; Wide range of measurement techniques including equipment and experienced personal; Flexible rearrangements of the core. The main experiments included: Pin wise flux distribution measurements; VVER-440 and VVER-1000 mock-ups; compact spent fuel storage; space kinetics experiment; core parameters experimental determination; experiment with new design fuel assembly; WWER-440 control assembly influence; and burnable absorber study. International research projects are also described. (P.A.)

International Reactor Physics Experiment Evaluation (IRPhE) Project

International Nuclear Information System (INIS)

2013-01-01

The International Reactor Physics Experiment Evaluation (IRPhE) Project aims to provide the nuclear community with qualified benchmark data sets by collecting reactor physics experimental data from nuclear facilities, worldwide. More specifically the objectives of the expert group are as follows: - maintaining an inventory of the experiments that have been carried out and documented; - archiving the primary documents and data released in computer-readable form; - promoting the use of the format and methods developed and seek to have them adopted as a standard. For those experiments where interest and priority is expressed by member countries or working parties and executive groups within the NEA provide guidance or co-ordination in: - compiling experiments into a standard international agreed format; - verifying the data, to the extent possible, by reviewing original and subsequently revised documentation, and by consulting with the experimenters or individuals who are familiar with the experimenters or the experimental facility; - analysing and interpreting the experiments with current state-of-the-art methods; - publishing electronically the benchmark evaluations. The expert group will: - identify gaps in data and provide guidance on priorities for future experiments; - involve the young generation (Masters and PhD students and young researchers) to find an effective way of transferring know-how in experimental techniques and analysis methods; - provide a tool for improved exploitation of completed experiments for Generation IV reactors; - coordinate closely its work with other NSC experimental work groups in particular the International Criticality Safety Benchmark Evaluation Project (ICSBEP), the Shielding Integral Benchmark Experiment Data Base (SINBAD) and others, e.g. knowledge preservation in fast reactors of the IAEA, the ANS Joint Benchmark Activities; - keep a close link with the working parties on scientific issues of reactor systems (WPRS), the expert

Core physics design calculation of mini-type fast reactor based on Monte Carlo method

International Nuclear Information System (INIS)

He Keyu; Han Weishi

2007-01-01

An accurate physics calculation model has been set up for the mini-type sodium-cooled fast reactor (MFR) based on MCNP-4C code, then a detailed calculation of its critical physics characteristics, neutron flux distribution, power distribution and reactivity control has been carried out. The results indicate that the basic physics characteristics of MFR can satisfy the requirement and objectives of the core design. The power density and neutron flux distribution are symmetrical and reasonable. The control system is able to make a reliable reactivity balance efficiently and meets the request for long-playing operation. (authors)

Proceedings of the symposium on the physics and technology of reactors

International Nuclear Information System (INIS)

1993-01-01

The symposium aimed at providing the opportunity for promoting the subject and for developing the human resources in this important field in the Arab States. The symposium included 32 lectures on the following topics related to research reactors: design and development, training and operation, calculations of reactor parameters, nuclear reactions dynamics and control, reactor physics, neutron pyhsics, neutron activation analysis, in-core reactor radiation protection and shielding calculations. The lectures of the symposium were distributed over 7 sessions. An additional session was held by all participants for open discussion and recommendations

78 FR 50313 - Physical Protection of Irradiated Reactor Fuel in Transit

Science.gov (United States)

2013-08-19

... Irradiated Reactor Fuel in Transit AGENCY: Nuclear Regulatory Commission. ACTION: Orders; rescission. SUMMARY... the NRC published a final rule, ``Physical Protection of Irradiated Fuel in Transit,'' on May 20, 2013... of Irradiated Reactor Fuel in Transit'' (RIN 3150-AI64; NRC-2009-0163). The final rule incorporates...

Advancements in reactor physics modelling methodology of Monte Carlo Burnup Code MCB dedicated to higher simulation fidelity of HTR cores

International Nuclear Information System (INIS)

Cetnar, Jerzy

2014-01-01

The recent development of MCB - Monte Carlo Continuous Energy Burn-up code is directed towards advanced description of modern reactors, including double heterogeneity structures that exist in HTR-s. In this, we exploit the advantages of MCB methodology in integrated approach, where physics, neutronics, burnup, reprocessing, non-stationary process modeling (control rod operation) and refined spatial modeling are carried in a single flow. This approach allows for implementations of advanced statistical options like analysis of error propagation, perturbation in time domain, sensitivity and source convergence analyses. It includes statistical analysis of burnup process, emitted particle collection, thermal-hydraulic coupling, automatic power profile calculations, advanced procedures of burnup step normalization and enhanced post processing capabilities. (author)

Global physical and numerical stability of a nuclear reactor core

International Nuclear Information System (INIS)

Morales-Sandoval, Jaime; Hernandez-Solis, Augusto

2005-01-01

Low order models are used to investigate the influence of integration methods on observed power oscillations of some nuclear reactor simulators. The zero-power point reactor kinetics with six-delayed neutron precursor groups are time discretized using explicit, implicit and Crank-Nicholson methods, and the stability limit of the time mesh spacing is exactly obtained by locating their characteristic poles in the z-transform plane. These poles are the s to z mappings of the inhour equation roots and, except for one of them, they show little or no dependence on the integration method. Conditions for stable power oscillations can be also obtained by tracking when steady state output signals resulting from reactivity oscillations in the s-Laplace plane cross the imaginary axis. The dynamics of a BWR core operating at power conditions is represented by a reduced order model obtained by adding three ordinary differential equations, which can model void and Doppler reactivity feedback effects on power, and collapsing all delayed neutron precursors in one group. Void dynamics are modeled as a second order system and fuel heat transfer as a first order system. This model shows rich characteristics in terms of indicating the relative importance of different core parameters and conditions on both numerical and physical oscillations observed by large computer code simulations. A brief discussion of the influence of actual core and coolant conditions on the reduced order model is presented

Reflector and Protections in a Sodium-cooled Fast Reactor: Modelling and Optimization

Science.gov (United States)

Blanchet, David; Fontaine, Bruno

2017-09-01

The ASTRID project (Advanced Sodium Technological Reactor for Industrial Demonstration) is a Generation IV nuclear reactor concept under development in France [1]. In this frame, studies are underway to optimize radial reflectors and protections. Considering radial protections made in natural boron carbide, this study is conducted to assess the neutronic performances of the MgO as the reference choice for reflector material, in comparison with other possible materials including a more conventional stainless steel. The analysis is based upon a simplified 1-D and 2-D deterministic modelling of the reactor, providing simplified interfaces between core, reflector and protections. Such models allow examining detailed reaction rate distributions; they also provide physical insights into local spectral effects occurring at the Core-Reflector and at the Reflector-Protection interfaces.

Fast reactor physics at CEA: present studies and future prospects

International Nuclear Information System (INIS)

Hammer, P.

1980-09-01

This paper aims at giving a general survey of the fast reactor core physics and shielding studies wich are in progress at CEA (1979-1983) in order to solve the neutronic problems related to: - core design optimization, - reactor operation and fuel management, - safety, for the development of fast commercial breeders in France after the SUPER-PHENIX 1 construction is achieved

The Multi一physics Research on I ron一Core Vibration Noise of Power Reactor

Directory of Open Access Journals (Sweden)

LI U Ja

2017-02-01

Full Text Available On the basis of theoretical research releted to the magnetostriction and maxwell’.s equations，the fi- nite element coupling in the transient electromagnetic field coupling，structure and sound field coupling has been developed In thts paper by using the flnlte element sOftWare CO}IS01., Whleh establish a serles three-phase COT’e re- actor model, to analyzing the power frequency magnetic field distribution，core magnetostrictive displacement，max- well force displacement and sound pressure level of the three-phase series core reactor under the power frequency working state. According to transient magnetic field distribution in the simulation of the reactor，the magnetic flux density distribution inside the reactor and the vibration displacement distribution are calculated，the acoustic field distribution is measured alao. It is shown that physical field simulation results and measured data are basically in consisent by experiment，it is proved multi-physics coupling is an effective method for forecast of noise.

Nuclear reactor fuel rod behavior modelling and current trends

International Nuclear Information System (INIS)

Colak, Ue.

2001-01-01

Safety assessment of nuclear reactors is carried out by simulating the events to taking place in nuclear reactors by realistic computer codes. Such codes are developed in a way that each event is represented by differential equations derived based on physical laws. Nuclear fuel is an important barrier against radioactive fission gas release. The release of radioactivity to environment is the main concern and this can be avoided by preserving the integrity of fuel rod. Therefore, safety analyses should cover an assessment of fuel rod behavior with certain extent. In this study, common approaches for fuel behavior modeling are discussed. Methods utilized by widely accepted computer codes are reviewed. Shortcomings of these methods are explained. Current research topics to improve code reliability and problems encountered in fuel rod behavior modeling are presented

An overview of the current status of resonance theory in reactor physics applications

International Nuclear Information System (INIS)

Hwang, R.N.

1993-01-01

The neutron resonance phenomena constitute one of the most fundamental subjects in nuclear physics as well as in reactor physics. It is the area where the concepts of nuclear interaction and the treatment of the neutronic balance in reactor lattices become intertwined. The later requires the detailed knowledge of resonance structures of many nuclide of practical interest to the development of nuclear energy. The key issue of the resonance treatment in reactor applications is directly associated with the use of the microscopic cross sections in the macroscopic reactor cells with a wide range of composition, temperature,and geometric configurations. It gives rise to the so called self-shielding effect. The accurate estimations of such a effect is essential not only in the calculation of the criticality of a reactor but also from the point of view of safety considerations. The latter manifests through the Doppler effect particularly crucial to the fast reactor development. The task of accurate treatment of the self-shielding effect, however, is by no means simple. In fact, it is perhaps the most complicated problem in neutron physics which, strictly speaking, requires the dependence of many physical variables. Two important elements of particular interest are : (1) a concise description of the resonance cross sections as a function of energy and temperature; (2) accurate estimation of the corresponding neutron flux where appropriate. These topics will be discussed from both the historical as well as the state-of-art perspectives

PIK3CA-associated developmental disorders exhibit distinct classes of mutations with variable expression and tissue distribution

NARCIS (Netherlands)

Mirzaa, Ghayda; Timms, Andrew E.; Conti, Valerio; Boyle, Evan August; Girisha, Katta M.; Martin, Beth; Kircher, Martin; Olds, Carissa; Juusola, Jane; Collins, Sarah; Park, Kaylee; Carter, Melissa; Glass, Ian; Krägeloh-Mann, Inge; Chitayat, David; Parikh, Aditi Shah; Bradshaw, Rachael; Torti, Erin; Braddock, Stephen; Burke, Leah; Ghedia, Sondhya; Stephan, Mark; Stewart, Fiona; Prasad, Chitra; Napier, Melanie; Saitta, Sulagna; Straussberg, Rachel; Gabbett, Michael; O'Connor, Bridget C.; Keegan, Catherine E.; Yin, Lim Jiin; Lai, Angeline Hwei Meeng; Martin, Nicole; McKinnon, Margaret; Addor, Marie-Claude; Boccuto, Luigi; Schwartz, Charles E.; Lanoel, Agustina; Conway, Robert L.; Devriendt, Koenraad; Tatton-Brown, Katrina; Pierpont, Mary Ella; Painter, Michael; Worgan, Lisa; Reggin, James; Hennekam, Raoul; Tsuchiya, Karen; Pritchard, Colin C.; Aracena, Mariana; Gripp, Karen W.; Cordisco, Maria; Esch, Hilde Van; Garavelli, Livia; Curry, Cynthia; Goriely, Anne; Kayserilli, Hulya; Shendure, Jay; Graham, John; Guerrini, Renzo; Dobyns, William B.

2016-01-01

Mosaicism is increasingly recognized as a cause of developmental disorders with the advent of next-generation sequencing (NGS). Mosaic mutations of PIK3CA have been associated with the widest spectrum of phenotypes associated with overgrowth and vascular malformations. We performed targeted NGS

Fast reactors fuel cycle core physics results from the CAPRA-CADRA programme

Energy Technology Data Exchange (ETDEWEB)

Vasile, A.; Rimpault, G.; Tommasi, J.; Saint Jean, C. de; Delpech, M. [CEA Cadarache, 13 - Saint Paul lez Durance (France); Hesketh, K. [BNFL, Inc., Denver, CO (United States); Beaumont, H.M.; Sunderland, R.E. [NNC Ltd. (United Kingdom); Newton, T.; Smith, P. [AEA Technology (United Kingdom); Raedt, Ch. de [SCK.CEN, Mol (Belgium); Vambenepe, G. [Electricite de France (EDF), 75 - Paris (France); Lefevre, J.C. [FRAMATOME, 92 - Paris-La-Defence (France); Maschek, W.; Haas, D

2001-07-01

This paper presents an overview of fast reactor core physics results obtained in the context of the CAPRA-CADRA European collaborative programme, whose aim is to investigate a broad range of possible options for plutonium and radioactive waste management. Different types of fast reactors have been studied to evaluate their potential capabilities with respect to the long term management of plutonium, minor actinides (MAs) and long- lived fission products (LLFPs). Among the several options aiming at reducing waste and consequently radio toxicity are: homogeneous recycling of Minor Actinides, heterogeneous recycling of Minor Actinides either without or with moderation, dedicated critical cores (fuelled mainly with Minor Actinides) and Accelerator Driven System (ADS) variants. In order to achieve a detailed understanding of the potential of the various options, advanced core physics methods have been implemented and tested and applied, for example, to improving control rod modeling and to studying safety aspects. There has also been code development and experimental work carried out to improve the understanding of fuel performance behaviors. (author)

Fast reactors fuel cycle core physics results from the CAPRA-CADRA programme

International Nuclear Information System (INIS)

Vasile, A.; Rimpault, G.; Tommasi, J.; Saint Jean, C. de; Delpech, M.; Hesketh, K.; Beaumont, H.M.; Sunderland, R.E.; Newton, T.; Smith, P.; Raedt, Ch. de; Vambenepe, G.; Lefevre, J.C.; Maschek, W.; Haas, D

2001-01-01

This paper presents an overview of fast reactor core physics results obtained in the context of the CAPRA-CADRA European collaborative programme, whose aim is to investigate a broad range of possible options for plutonium and radioactive waste management. Different types of fast reactors have been studied to evaluate their potential capabilities with respect to the long term management of plutonium, minor actinides (MAs) and long- lived fission products (LLFPs). Among the several options aiming at reducing waste and consequently radio toxicity are: homogeneous recycling of Minor Actinides, heterogeneous recycling of Minor Actinides either without or with moderation, dedicated critical cores (fuelled mainly with Minor Actinides) and Accelerator Driven System (ADS) variants. In order to achieve a detailed understanding of the potential of the various options, advanced core physics methods have been implemented and tested and applied, for example, to improving control rod modeling and to studying safety aspects. There has also been code development and experimental work carried out to improve the understanding of fuel performance behaviors. (author)

Monte Carlo simulation of core physics parameters of the Nigeria Research Reactor-1 (NIRR-1)

Energy Technology Data Exchange (ETDEWEB)

Jonah, S.A. [Reactor Engineering Section, Centre for Energy Research and Training, Ahmadu Bello University, Zaria, P.M.B. 1014 (Nigeria)], E-mail: jonahsa2001@yahoo.com; Liaw, J.R.; Matos, J.E. [RERTR Program, Nuclear Engineering Division, Argonne National Laboratory, 9700 S. Cass Avenue, Argonne, IL 60439 (United States)

2007-12-15

The Monte Carlo N-Particle (MCNP) code, version 4C (MCNP4C) and a set of neutron cross-section data were used to develop an accurate three-dimensional computational model of the Nigeria Research Reactor-1 (NIRR-1). The geometry of the reactor core was modeled as closely as possible including the details of all the fuel elements, reactivity regulators, the control rod, all irradiation channels, and Be reflectors. The following reactor core physics parameters were calculated for the present highly enriched uranium (HEU) core: clean cold core excess reactivity ({rho}{sub ex}), control rod (CR) and shim worth, shut down margin (SDM), neutron flux distributions in the irradiation channels, reactivity feedback coefficients and the kinetics parameters. The HEU input model was validated by experimental data from the final safety analyses report (SAR). The model predicted various key neutronics parameters fairly accurately and the calculated thermal neutron fluxes in the irradiation channels agree with the values obtained by foil activation method. Results indicate that the established Monte Carlo model is an accurate representation of the NIRR-1 HEU core and will be used to perform feasibility for conversion to low enriched uranium (LEU)

Study and application of digital physical start-up system for nuclear reactor

International Nuclear Information System (INIS)

Qu Ronghong; Li Baoxiang; Xu Xiaolin

2004-01-01

The digital physical start-up system for nuclear reactor is introduced. The system was used successfully in physical start-up experiment of 10 MW high-temperature gas-cooled reactor. It is proved practically that the system not only runs reliably and calculates both rapidly and correctly and relieves the loads of operators, but also has the better characters of monitoring and showing the real-time results of experiments than the analog systems. (author)

Neutron physics computation of CERCA fuel elements for Maria Reactor

International Nuclear Information System (INIS)

Andrzejewski, K.J.; Kulikowska, T.; Marcinkowska, Z.

2008-01-01

Neutron physics parameters of CERCA design fuel elements were calculated in the framework of the RERTR (Reduced Enrichment for Research and Test Reactors) program for Maria reactor. The analysis comprises burnup of experimental CERCA design fuel elements for 4 cycles in Maria Reactor To predict the behavior of the mixed core the differences between the CERCA fuel (485 g U-235 as U 3 Si 2 , 5 fuel tubes, low enrichment 19.75 % - LEU) and the presently used MR-6 fuel (430 g as UO 2 , 6 fuel tubes, high enrichment 36 % - HEU) had to be taken into account. The basic tool used in neutron-physics analysis of Maria reactor is program REBUS using in its dedicated libraries of effective microscopic cross sections. The cross sections were prepared using WIMS-ANL code, taking into account the actual structure, temperature and material composition of the fuel elements required preparation of new libraries.The problem is described in the first part of the present paper. In the second part the applicability of the new library is shown on the basis of the fuel core computational analysis. (author)

Developments in Sensitivity Methodologies and the Validation of Reactor Physics Calculations

Directory of Open Access Journals (Sweden)

Giuseppe Palmiotti

2012-01-01

Full Text Available The sensitivity methodologies have been a remarkable story when adopted in the reactor physics field. Sensitivity coefficients can be used for different objectives like uncertainty estimates, design optimization, determination of target accuracy requirements, adjustment of input parameters, and evaluations of the representativity of an experiment with respect to a reference design configuration. A review of the methods used is provided, and several examples illustrate the success of the methodology in reactor physics. A new application as the improvement of nuclear basic parameters using integral experiments is also described.

Engineering and physics of high-power-density, compact, reversed-field-pinch fusion reactors

International Nuclear Information System (INIS)

Najmabadi, F.; Conn, R.W.; Krakowski, R.A.; Schultz, K.R.; Steiner, D.

1989-01-01

The technical feasibility and key developmental issues of compact, high-power-density Reversed-Field-Pinch (RFP) reactors are the primary results of the TITAN RFP reactor study. Two design approaches emerged, TITAN-I and TITAN-II, both of which are steady-state, DT-burning, circa 1000 MWe power reactors. The TITAN designs are physically compact and have a high neutron wall loading of 18 MW m 2 . Detailed analyses indicate that: a) each design is technically feasible; b) attractive features of compact RFP reactors can be realized without sacrificing the safety and environmental potential of fusion; and c) major features of this particular embodiment of the RFP reactor are retained in a design window of neutron wall loading ranging from 10 to 20 MW/m 2 . A major product of the TITAN study is the identification and quantification of major engineering and physics requirements for this class of RFP reactors. These findings are the focus of this paper. (author). 26 refs.; 4 figs.; 1 tab

A CFD model for biomass fast pyrolysis in fluidized-bed reactors

Science.gov (United States)

Xue, Qingluan; Heindel, T. J.; Fox, R. O.

2010-11-01

A numerical study is conducted to evaluate the performance and optimal operating conditions of fluidized-bed reactors for fast pyrolysis of biomass to bio-oil. A comprehensive CFD model, coupling a pyrolysis kinetic model with a detailed hydrodynamics model, is developed. A lumped kinetic model is applied to describe the pyrolysis of biomass particles. Variable particle porosity is used to account for the evolution of particle physical properties. The kinetic scheme includes primary decomposition and secondary cracking of tar. Biomass is composed of reference components: cellulose, hemicellulose, and lignin. Products are categorized into groups: gaseous, tar vapor, and solid char. The particle kinetic processes and their interaction with the reactive gas phase are modeled with a multi-fluid model derived from the kinetic theory of granular flow. The gas, sand and biomass constitute three continuum phases coupled by the interphase source terms. The model is applied to investigate the effect of operating conditions on the tar yield in a fluidized-bed reactor. The influence of various parameters on tar yield, including operating temperature and others are investigated. Predicted optimal conditions for tar yield and scale-up of the reactor are discussed.

Hamiltonian circuited simulations in reactor physics

International Nuclear Information System (INIS)

Rio Hirowati Shariffudin

2002-01-01

In the assessment of suitability of reactor designs and in the investigations into reactor safety, the steady state of a nuclear reactor has to be studied carefully. The analysis can be done through mockup designs but this approach costs a lot of money and consumes a lot of time. A less expensive approach is via simulations where the reactor and its neutron interactions are modelled mathematically. Finite difference discretization of the diffusion operator has been used to approximate the steady state multigroup neutron diffusion equations. The steps include the outer scheme which estimates the resulting right hand side of the matrix equation, the group scheme which calculates the upscatter problem and the inner scheme which solves for the flux for a particular group. The Hamiltonian circuited simulations for the inner iterations of the said neutron diffusion equation enable the effective use of parallel computing, especially where the solutions of multigroup neutron diffusion equations involving two or more space dimensions are required. (Author)

Fusion reactor physics and technology. Progress report, October 1, 1978-June 30, 1979

International Nuclear Information System (INIS)

Conn, R.W.; Kulcinski, G.L.; Maynard, C.W.

1979-01-01

During the present contract period, work has been carried out in the following areas: (a) The NUWMAK tokamak reactor design was completed and distributed throughout the community. In particular, specific work was completed on divertorless tokamak operation in NUWMAK, Ti alloy assessment, materials resource implications of NUWMAK style reactors, and an economic analysis; (b) Tandem mirror reactor technology studies were carried out on tandem mirror physics, the role of rf heating, power balance studies, the design of high field magnets, and blanket/shield design in TMR's; (c) work at Wisconsin is contributing to the evolving picture of an optimum TMR; (d) the WHIST tokamak reactor plasma transport code developed at Wisconsin has been extended in two directions; (e) Work on ICRF heating in tokamak reactors, both in terms of physics and launching structure design, has been completed and published

A simulated test of physical starting and reactor physics on zero power facility of PWR

International Nuclear Information System (INIS)

Yao Zewu; Ji Huaxiang; Chen Zhicheng; Yao Zhiquan; Chen Chen; Li Yuwen

1995-01-01

The core neutron economics has been verified through experiments conducted at a zero power reactor with baffles of various thickness. A simulated test of physical starting of Qinshan PWR has been introduced. The feasibility and safety of the programme are verified. The research provides a valuable foundation for developing physical starting programme

Research on V and V strategy of reactor physics code of COSINE

International Nuclear Information System (INIS)

Liu Zhanquan; Chen Yixue; Yang Chao; Dang Halei

2013-01-01

Verification and validation (V and V) is very important for the software quality assurance. Reasonable and efficient V and V strategy can achieve twice the result with half the effort. Core and system integrated engine for design and analysis (COSINE) software package contains three reactor physics codes, the lattice code (LATC), the core simulator (CORE) and the kinetics code (KIND), which is called the reactor physics subsystem. The V and V strategy for the physics subsystem was researched based on the foundation of scientific software's V and V method. The module based verification method and the function based validation method were proposed, composing the physical subsystem V and V strategy of COSINE software package. (authors)

Development of safety analysis methodology for moderator system failure of CANDU-6 reactor by thermal-hydraulics/physics coupling

International Nuclear Information System (INIS)

Kim, Jong Hyun; Jin, Dong Sik; Chang, Soon Heung

2013-01-01

Highlights: • Developed new safety analysis methodology of moderator system failures for CANDU-6. • The new methodology used the TH-physics coupling concept. • Thermalhydraulic code is CATHENA, physics code is RFSP-IST. • Moderator system failure ends to the subcriticality through self-shutdown. -- Abstract: The new safety analysis methodology for the CANDU-6 nuclear power plant (NPP) moderator system failure has been developed by using the coupling technology with the thermalhydraulic code, CATHENA and reactor core physics code, RFSP-IST. This sophisticated methodology can replace the legacy methodology using the MODSTBOIL and SMOKIN-G2 in the field of the thermalhydraulics and reactor physics, respectively. The CATHENA thermalhydraulic model of the moderator system can simulate the thermalhydraulic behaviors of all the moderator systems such as the calandria tank, head tank, moderator circulating circuit and cover gas circulating circuit and can also predict the thermalhydraulic property of the moderator such as moderator density, temperature and water level in the calandria tank as the moderator system failures go on. And these calculated moderator thermalhydraulic properties are provided to the 3-dimensional neutron kinetics solution module – CERBRRS of RFSP-IST as inputs, which can predict the change of the reactor power and provide the calculated reactor power to the CATHENA. These coupling calculations are performed at every 2 s time steps, which are equivalent to the slow control of CANDU-6 reactor regulating systems (RRS). The safety analysis results using this coupling methodology reveal that the reactor operation enters into the self-shutdown mode without any engineering safety system and/or human interventions for the postulated moderator system failures of the loss of heat sink and moderator inventory, respectively

Results of research and development activities in 1989 of the Institute for Neutron Physics and Reactor Technology

International Nuclear Information System (INIS)

1990-03-01

The Institute for Neutron Physics and Reactor Technology treats research problems of nuclear engineering, mainly those that are related to the development of sodium-cooled fast breeder reactors and fusion reactor technology. The activities are in approximately equal parts of an experimental and theoretical nature. A great part of the research activities is performed in co-operation with other institutes and industrial groups in the framework of projects. For the Fast Breeder Reactor Project the Institute works on reactor physical design and safety problems by the core of large-scale fast breeder reactors. Questions concerning the consequences of accidents in light water reactors upon the environment and the population are treated as part of the Nuclear Safety Project. The Institute contributes to the Reprocessing Project with theoretical investigations on the physics of the fuel cycle and by developing control devices for a reprocessing plant. In the framework of the Fusion Project the Institute is concerned with neutron physical and technological questions of the breeder blanket. (orig.) [de

Reactor physics using a microcomputer

International Nuclear Information System (INIS)

Murray, R.L.

1983-01-01

The object of the work reported is to develop educational computer modules for all aspects of reactor physics. The modules consist of a description of the theory, mathematical method, computer program listing, sample calculations, and problems for the student, along with a card deck. Modules were first written in FORTRAN for an IBM 360/75, then later in BASIC for microcomputers. Problems include: limitation of equipment, choice of format for the program, the variety of dialects of BASIC used in the different microcomputer and peripherals brands, and knowing when to quit in the process of developing a program

Physical characteristics of GE [General Electric] BWR [boiling-water reactor] fuel assemblies

International Nuclear Information System (INIS)

Moore, R.S.; Notz, K.J.

1989-06-01

The physical characteristics of fuel assemblies manufactured by the General Electric Company for boiling-water reactors are classified and described. The classification into assembly types is based on the GE reactor product line, the Characteristics Data Base (CDB) assembly class, and the GE fuel design. Thirty production assembly types are identified. Detailed physical data are presented for each assembly type in an appendix. Descriptions of special (nonstandard) fuels are also reported. 52 refs., 1 fig., 6 tabs

Deterministic Modeling of the High Temperature Test Reactor

International Nuclear Information System (INIS)

Ortensi, J.; Cogliati, J.J.; Pope, M.A.; Ferrer, R.M.; Ougouag, A.M.

2010-01-01

Idaho National Laboratory (INL) is tasked with the development of reactor physics analysis capability of the Next Generation Nuclear Power (NGNP) project. In order to examine INL's current prismatic reactor deterministic analysis tools, the project is conducting a benchmark exercise based on modeling the High Temperature Test Reactor (HTTR). This exercise entails the development of a model for the initial criticality, a 19 column thin annular core, and the fully loaded core critical condition with 30 columns. Special emphasis is devoted to the annular core modeling, which shares more characteristics with the NGNP base design. The DRAGON code is used in this study because it offers significant ease and versatility in modeling prismatic designs. Despite some geometric limitations, the code performs quite well compared to other lattice physics codes. DRAGON can generate transport solutions via collision probability (CP), method of characteristics (MOC), and discrete ordinates (Sn). A fine group cross section library based on the SHEM 281 energy structure is used in the DRAGON calculations. HEXPEDITE is the hexagonal z full core solver used in this study and is based on the Green's Function solution of the transverse integrated equations. In addition, two Monte Carlo (MC) based codes, MCNP5 and PSG2/SERPENT, provide benchmarking capability for the DRAGON and the nodal diffusion solver codes. The results from this study show a consistent bias of 2-3% for the core multiplication factor. This systematic error has also been observed in other HTTR benchmark efforts and is well documented in the literature. The ENDF/B VII graphite and U235 cross sections appear to be the main source of the error. The isothermal temperature coefficients calculated with the fully loaded core configuration agree well with other benchmark participants but are 40% higher than the experimental values. This discrepancy with the measurement stems from the fact that during the experiments the control

A Numerical Model for Trickle Bed Reactors

Science.gov (United States)

Propp, Richard M.; Colella, Phillip; Crutchfield, William Y.; Day, Marcus S.

2000-12-01

Trickle bed reactors are governed by equations of flow in porous media such as Darcy's law and the conservation of mass. Our numerical method for solving these equations is based on a total-velocity splitting, sequential formulation which leads to an implicit pressure equation and a semi-implicit mass conservation equation. We use high-resolution finite-difference methods to discretize these equations. Our solution scheme extends previous work in modeling porous media flows in two ways. First, we incorporate physical effects due to capillary pressure, a nonlinear inlet boundary condition, spatial porosity variations, and inertial effects on phase mobilities. In particular, capillary forces introduce a parabolic component into the recast evolution equation, and the inertial effects give rise to hyperbolic nonconvexity. Second, we introduce a modification of the slope-limiting algorithm to prevent our numerical method from producing spurious shocks. We present a numerical algorithm for accommodating these difficulties, show the algorithm is second-order accurate, and demonstrate its performance on a number of simplified problems relevant to trickle bed reactor modeling.

Reactor physics studies in the GCFR phase-II critical assembly

International Nuclear Information System (INIS)

Pond, R.B.

1976-09-01

The reactor physics studies performed in the gas cooled fast reactor (GCFR) mockup on ZPR-9 are covered. This critical assembly, designated Phase II in the GCFR program, had a single zone PuO 2 -UO 2 core composition and UO 2 radial and axial blankets. The assembly was built both with and without radial and axial stainless steel reflectors. The program included the following measurements: small-sample reactivity worths of reactor constituent materials (including helium); 238 U Doppler effect; uranium and plutonium reaction rate distributions; thorium, uranium, and plutonium α and reactor kinetics. Analysis of the measurements used ENDF/B-IV nuclear data; anisotropic diffusion coefficients were used to account for neutron streaming effects. Comparison of measurements and calculations to GCFR Phase I are also made

Newly Available Reactor Physics Benchmark data in the March 2011 Edition of the IRPhEP Handbook

International Nuclear Information System (INIS)

Bess, John D.; Briggs, J. Blair; Gulliford, Jim

2011-01-01

The International Reactor Physics Experiment Evaluation Project (IRPhEP) was established to preserve integral reactor physics experimental data, including separate or special effects data for nuclear energy and technology applications. Numerous experiments that have been performed worldwide, represent a large investment of infrastructure, expertise, and cost, and are valuable resources of data for present and future research. These valuable assets provide the basis for recording, development, and validation of methods. If the data are compromised, it is unlikely that any of these measurements would be repeated in the future. The purpose of the IRPhEP is to provide an extensively peer-reviewed set of reactor physics-related integral data that can be used by reactor designers and safety analysts to validate the analytical tools used to design next-generation reactors and establish the safety basis for operation of these reactors. Contributors from around the world collaborate in the evaluation and review of selected benchmark experiments for inclusion in the International Handbook of Evaluated Reactor Physics Benchmark Experiments (IRPhEP Handbook). Several new evaluations have been prepared for inclusion in the March 2011 edition of the IRPhEP Handbook.

Numerical modeling of disperse material evaporation in axisymmetric thermal plasma reactor

Directory of Open Access Journals (Sweden)

Stefanović Predrag Lj.

2003-01-01

Full Text Available A numerical 3D Euler-Lagrangian stochastic-deterministic (LSD model of two-phase flow laden with solid particles was developed. The model includes the relevant physical effects, namely phase interaction, panicle dispersion by turbulence, lift forces, particle-particle collisions, particle-wall collisions, heat and mass transfer between phases, melting and evaporation of particles, vapour diffusion in the gas flow. It was applied to simulate the processes in thermal plasma reactors, designed for the production of the ceramic powders. Paper presents results of extensive numerical simulation provided (a to determine critical mechanism of interphase heat and mass transfer in plasma flows, (b to show relative influence of some plasma reactor parameters on solid precursor evaporation efficiency: 1 - inlet plasma temperature, 2 - inlet plasma velocity, 3 - particle initial diameter, 4 - particle injection angle a, and 5 - reactor wall temperature, (c to analyze the possibilities for high evaporation efficiency of different starting solid precursors (Si, Al, Ti, and B2O3 powder, and (d to compare different plasma reactor configurations in conjunction with disperse material evaporation efficiency.

State space modeling of reactor core in a pressurized water reactor

Energy Technology Data Exchange (ETDEWEB)

Ashaari, A.; Ahmad, T.; M, Wan Munirah W. [Department of Mathematical Science, Faculty of Science, Universiti Teknologi Malaysia, 81310 Skudai, Johor (Malaysia); Shamsuddin, Mustaffa [Institute of Ibnu Sina, Universiti Teknologi Malaysia, 81310 Skudai, Johor (Malaysia); Abdullah, M. Adib [Swinburne University of Technology, Faculty of Engineering, Computing and Science, Jalan Simpang Tiga, 93350 Kuching, Sarawak (Malaysia)

2014-07-10

The power control system of a nuclear reactor is the key system that ensures a safe operation for a nuclear power plant. However, a mathematical model of a nuclear power plant is in the form of nonlinear process and time dependent that give very hard to be described. One of the important components of a Pressurized Water Reactor is the Reactor core. The aim of this study is to analyze the performance of power produced from a reactor core using temperature of the moderator as an input. Mathematical representation of the state space model of the reactor core control system is presented and analyzed in this paper. The data and parameters are taken from a real time VVER-type Pressurized Water Reactor and will be verified using Matlab and Simulink. Based on the simulation conducted, the results show that the temperature of the moderator plays an important role in determining the power of reactor core.

Development of an automated core model for nuclear reactors

International Nuclear Information System (INIS)

Mosteller, R.D.

1998-01-01

This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The objective of this project was to develop an automated package of computer codes that can model the steady-state behavior of nuclear-reactor cores of various designs. As an added benefit, data produced for steady-state analysis also can be used as input to the TRAC transient-analysis code for subsequent safety analysis of the reactor at any point in its operating lifetime. The basic capability to perform steady-state reactor-core analysis already existed in the combination of the HELIOS lattice-physics code and the NESTLE advanced nodal code. In this project, the automated package was completed by (1) obtaining cross-section libraries for HELIOS, (2) validating HELIOS by comparing its predictions to results from critical experiments and from the MCNP Monte Carlo code, (3) validating NESTLE by comparing its predictions to results from numerical benchmarks and to measured data from operating reactors, and (4) developing a linkage code to transform HELIOS output into NESTLE input

Advanced High-Temperature Reactor Dynamic System Model Development: April 2012 Status

Energy Technology Data Exchange (ETDEWEB)

Qualls, A L; Cetiner, M S; Wilson, Jr, T L

2012-04-30

system relate to flows within the reactor vessel during severe events and the resulting temperature profiles (temperature and duration) for major components. Critical components include the fuel, reactor vessel, primary piping, and the primary-to-intermediate heat exchangers (P-IHXs). The major AHTR power system loops are shown in Fig. 3. The intermediate heat transfer system is a group of three pumped salt loops that transports the energy produced in the primary system to the power conversion system. Two dynamic system models are used to analyze the AHTR. A Matlab/Simulink-based model initiated in 2011 has been updated to reflect the evolving design parameters related to the heat flows associated with the reactor vessel. The Matlab model utilizes simplified flow assumptions within the vessel and incorporates an empirical representation of the Direct Reactor Auxiliary Cooling System (DRACS). A Dymola/Modelica model incorporates a more sophisticated representation of primary coolant flow and a physics-based representation of the three-loop DRACS thermal hydraulics. This model is not currently operating in a fully integrated mode. The Matlab model serves as a prototype and provides verification for the Dymola model, and its use will be phased out as the Dymola model nears completion. The heat exchangers in the system are sized using spreadsheet-based, steady-state calculations. The detail features of the heat exchangers are programmed into the dynamic models, and the overall dimensions are used to generate realistic plant designs. For the modeling cases where the emphasis is on understanding responses within the intermediate and primary systems, the power conversion system may be modeled as a simple boundary condition at the intermediate-to-power conversion system heat exchangers.

Proceedings of 2. Yugoslav symposium on reactor physics, Part 3, Herceg Novi (Yugoslavia), 27-29 Sep 1966; 2. Jugoslovenski simpozijum iz reaktorske fizike, Deo 3, Herceg Novi (Yugoslavia), 27-29 Sep 1966

Energy Technology Data Exchange (ETDEWEB)

NONE

1966-07-01

This Volume 3 of the Proceedings of 2. Yugoslav symposium on reactor physics includes three papers describing the following: model for spatial synthesis of automated control system of the GCR type reactor; model for analysis of hydrodynamic processes at the BHWR type reactors; mathematical model for safety analysis of heavy water power reactor.

Modeling of the reactor core

International Nuclear Information System (INIS)

1999-01-01

In order to improve technical - economical parameters fuel with 2.4% enrichment and burnable absorber is started to be used at Ignalina NPP. Using code QUABOX/CUBBOX the main neutronic - physical characteristics were calculated for selected reactor core conditions

Physics and engineering aspects of the EBT reactor

International Nuclear Information System (INIS)

Uckan, N.A.; Bettis, E.S.; Hedrick, C.L.; Santoro, R.T.; Watts, H.L.; Yeh, H.T.

1977-01-01

The ELMO Bumpy Torus (EBT) reactor has the advantage of high-β, steady-state operation. The first reactor study based on the EBT confinement concept was initiated in 1976. It provided the required starting point for continued assessment of the validity of the concept. A new design based on the present physics understanding, practical design approaches, and present and near-term technologies has been established. One of the important factors in an EBT reactor is the large aspect ratio (large toroidal major radius as well). This leads to a power plant with a comparatively large total energy output, usually in the range of 2000-6000 MW(th) for a conventional neutron wall loading of 1-2 MW/m 2 (the high value of β in an EBT device provides a net cost per unit energy roughly equal to or somewhat less than that for a Tokamak system). The large aspect ratio also provides very simple engineering and design requirements because of good access and small force loading asymmetries. Another important factor is the steady-state operation. In an EBT system, less power handling, energy storage, and filtering equipment will be needed. An EBT reactor is less likely to be subject to thermal and mechanical fatigue than reactors with large pulsed magnetic fields and short bursts of fusion power. The details of the key design elements and critical scientific and technology factors which are substantially different from other fusion reactor approaches are described

Methods for reactor physics calculations for control rods in fast reactors

International Nuclear Information System (INIS)

Grimstone, M.J.; Rowlands, J.L.

1988-12-01

The IAEA Specialists' Meeting on ''Methods for Reactor Physics Calculations for Control Rods in Fast Reactors'' was held in Winfrith, United Kingdom, on 6-8 December, 1988. The meeting was attended by 23 participants from nine countries. The purpose of the meeting was to review the current calculational methods and their accuracy as assessed by theoretical studies and comparisons with measurements, and then to identify the requirements for improved methods or additional studies and comparisons. The control rod properties or effects to be considered were their reactivity worths, their effect on the power distribution through the core, and the reaction rates and energy deposition both within and adjacent to the rods. The meeting was divided into five sessions, in the first of which each national delegation presented a brief overview of their programme of work on calculational methods for fast reactor control rods. In the next three sessions a total of seventeen papers were presented describing calculational methods and assessments of their accuracy. The final session was a discussion to draw conclusions regarding the current status of methods and the further developments and validation work required. A separate abstract was prepared for each of the 23 papers presented at the meeting. Refs, figs and tabs

A review of reactor physics uncertainties and validation requirements for the modular high-temperature gas-cooled reactor

International Nuclear Information System (INIS)

Baxter, A.M.; Lane, R.K.; Hettergott, E.; Lefler, W.

1991-01-01

The important, safety-related, physics parameters for the low-enriched Modular High-Temperature gas-Cooled Reactor (MHTGR) such as control rod worth, shutdown margins, temperature coefficients, and reactivity worths, are considered, and estimates are presented of the uncertainties in the calculated values of these parameters. The basis for the uncertainty estimate in several of the important calculated parameters is reviewed, including the available experimental data used in obtaining these estimates. Based on this review, the additional experimental data needed to complete the validation of the methods used to calculate these parameters is presented. The role of benchmark calculations in validating MHTGR reactor physics data is also considered. (author). 10 refs, 5 figs, 3 tabs

Study of plutonium recycling physics in light water reactors

International Nuclear Information System (INIS)

Reuss, Paul

1979-10-01

A stock of plutonium from the reprocessing of thermal neutron reactor fuel is likely to appear in the next few years. The use of this plutonium as fuel replacing 235 U in thermal reactors is probably more interesting than simple stock-piling storage: immobilization of a capital which moreover would deteriorate by radioactive decay of isotope 241 also fissile and present to an appreciable extend in plutonium from reprocessing (half-life 15 years); recycling, on the other hand, will supply energy without complete degradation of the stock for fast neutron reactor loads, the burned matter having been partially renewed by conversion; furthermore the use of plutonium will meet the needs created by a temporary pressure on the naturel and/or enriched uranium market. For these two reasons the recycling of plutonium in thermal neutron reactors is being considered seriously today. The present work is confined to neutronic aspects and centres mainly on pressurized water-moderated reactors, the most highly developed at present in France. Four aspects of the problem are examined: 1. the physics of a plutonium-recycling reactor special features of neutronic phenomena with respect to the 'conventional' scheme of the 235 U burning reactor; 2. calculation of a plutonium-recycling reactor: adaptation of standard methods; 3. qualification of these calculations from the viewpoint of both data and inevitable approximations; 4. the fuel cycle and particularly the equivalence of fissile matters [fr

Test on the reactor with the portable digital reactivity meter for physical experiment

International Nuclear Information System (INIS)

Huang Liyuan

2010-01-01

Test must be performed on the zero power reactor During the development of portable digital reactivity meter for physical experiment, in order to check its measurement function and accuracy. It describes the test facility, test core, test methods, test items and test results. The test results show that the instrument satisfy the requirements of technical specification, and satisfy the reactivity measurement in the physical experiments on reactors. (authors)

Chemical reactor modeling multiphase reactive flows

CERN Document Server

Jakobsen, Hugo A

2014-01-01

Chemical Reactor Modeling closes the gap between Chemical Reaction Engineering and Fluid Mechanics.  The second edition consists of two volumes: Volume 1: Fundamentals. Volume 2: Chemical Engineering Applications In volume 1 most of the fundamental theory is presented. A few numerical model simulation application examples are given to elucidate the link between theory and applications. In volume 2 the chemical reactor equipment to be modeled are described. Several engineering models are introduced and discussed. A survey of the frequently used numerical methods, algorithms and schemes is provided. A few practical engineering applications of the modeling tools are presented and discussed. The working principles of several experimental techniques employed in order to get data for model validation are outlined. The monograph is based on lectures regularly taught in the fourth and fifth years graduate courses in transport phenomena and chemical reactor modeling, and in a post graduate course in modern reactor m...

Methods and Models for the Coupled Neutronics and Thermal-Hydraulics Analysis of the CROCUS Reactor at EFPL

Directory of Open Access Journals (Sweden)

A. Rais

2015-01-01

Full Text Available In order to analyze the steady state and transient behavior of the CROCUS reactor, several methods and models need to be developed in the areas of reactor physics, thermal-hydraulics, and multiphysics coupling. The long-term objectives of this project are to work towards the development of a modern method for the safety analysis of research reactors and to update the Final Safety Analysis Report of the CROCUS reactor. A first part of the paper deals with generation of a core simulator nuclear data library for the CROCUS reactor using the Serpent 2 Monte Carlo code and also with reactor core modeling using the PARCS code. PARCS eigenvalue, radial power distribution, and control rod reactivity worth results were benchmarked against Serpent 2 full-core model results. Using the Serpent 2 model as reference, PARCS eigenvalue predictions were within 240 pcm, radial power was within 3% in the central region of the core, and control rod reactivity worth was within 2%. A second part reviews the current methodology used for the safety analysis of the CROCUS reactor and presents the envisioned approach for the multiphysics modeling of the reactor.

A model for steady-state and transient determination of subcooled boiling for calculations coupling a thermohydraulic and a neutron physics calculation program for reactor core calculation

International Nuclear Information System (INIS)

Mueller, R.G.

1987-06-01

Due to the strong influence of vapour bubbles on the nuclear chain reaction, an exact calculation of neutron physics and thermal hydraulics in light water reactors requires consideration of subcooled boiling. To this purpose, in the present study a dynamic model is derived from the time-dependent conservation equations. It contains new methods for the time-dependent determination of evaporation and condensation heat flow and for the heat transfer coefficient in subcooled boiling. Furthermore, it enables the complete two-phase flow region to be treated in a consistent manner. The calculation model was verified using measured data of experiments covering a wide range of thermodynamic boundary conditions. In all cases very good agreement was reached. The results from the coupling of the new calculation model with a neutron kinetics program proved its suitability for the steady-state and transient calculation of reactor cores. (orig.) [de

Stochastic processes analysis in nuclear reactor using ARMA models; Analiza stohastichkih procesa u nuklearnom reaktoru korishcjenjem ARMA modela

Energy Technology Data Exchange (ETDEWEB)

Zavaljevski, N [Institute of Nuclear Sciences Boris Kidric VINCA, Belgrade (Yugoslavia)

1990-07-01

The analysis of ARMA model derived from general stochastic state equations of nuclear reactor is given. The dependence of ARMA model parameters on the main physical characteristics of RB nuclear reactor in Vinca is presented. Preliminary identification results are presented, observed discrepancies between theory and experiment are explained and the possibilities of identification improvement are anticipated. (author)

Nuclear energy renaissance and reactor physics. Enlightenment of PHYSOR'08

International Nuclear Information System (INIS)

Peng Feng

2010-01-01

In relation to world's growing energy demands and concerns on global warming, nuclear energy as a sustainable resource is in its new period of renaissance. This is reflected in the record number of 447 papers on the International Conference on the Physics of Reactors--PHYSOR'08 held in Switzerland in 2008. The contents of these papers include the developments and frontiers in various directions of reactor physics. Featured by vast area of subjects, these emphasize the fact that the scope of the reactor physicist's R and D interests has expands considerably in recent years. The main keynote addresses and technical plenary lectures are briefly introduced. Some items concerned by the conference, such as: the status and perspective of nuclear energy's R and D, deployment and policy in main nuclear nations, the potential role of nuclear energy in mitigation global warming and slow down the GHG release, the sustainability of resource for nuclear energy utilization. Status and outlook about the needs of research and test facilities required in nuclear energy development, etc. are discussed. (authors)

The application of a multi-physics tool kit to spatial reactor dynamics

International Nuclear Information System (INIS)

Clifford, I.; Jasak, H.

2009-01-01

Traditionally coupled field nuclear reactor analysis has been carried out using several loosely coupled solvers, each having been developed independently from the others. In the field of multi-physics, the current generation of object-oriented tool kits provides robust close coupling of multiple fields on a single framework. This paper describes the initial results obtained as part of continuing research in the use of the OpenFOAM multi-physics tool kit for reactor dynamics application development. An unstructured, three-dimensional, time-dependent multi-group diffusion code Diffusion FOAM has been developed using the OpenFOAM multi-physics tool kit as a basis. The code is based on the finite-volume methodology and uses a newly developed block-coupled sparse matrix solver for the coupled solution of the multi-group diffusion equations. A description of this code is given with particular emphasis on the newly developed block-coupled solver, along with a selection of results obtained thus far. The code has performed well, indicating that the OpenFOAM tool kit is suited to reactor dynamics applications. This work has shown that the neutronics and simplified thermal-hydraulics of a reactor May be represented and solved for using a common calculation platform, and opens up the possibility for research into robust close-coupling of neutron diffusion and thermal-fluid calculations. This work has further opened up the possibility for research in a number of other areas, including research into three-dimensional unstructured meshes for reactor dynamics applications. (authors)

Package Flow Model and its fuzzy implementation for simulating nuclear reactor system dynamics

International Nuclear Information System (INIS)

Matsuoka, Hiroshi; Ishiguro, Misako.

1996-01-01

A simple intuitive simulation model, which we call 'Package Flow Model', has been developed to evaluate physical processes in nuclear reactor system from a macroscopic point of view. In the previous paper, we showed the physical process of each energy generation and transfer stage in a PWR could be modeled by PFM, and its dynamics could be approximately simulated by fuzzy implementation. In this paper, a PFMs network approach for a total PWR system simulation is proposed and some transients of nuclear ship 'MUTSU' reactor system are evaluated. The simulated results are consistent with those from Nuclear Ship Engineering Simulation System developed by JAERI. Furthermore, a visual representation method is proposed to intuitively capture the profile of fuel safety transient. Using the PFMs network, we can handily calculate the transient phenomena of the system even by a notebook-type personal computer. In addition, we can easily interpret the results of calculation surveying a small number of parameters. (author)

Applications of Oregon State University's TRIGA reactor in health physics education

International Nuclear Information System (INIS)

Higginbotham, J.F.

1990-01-01

The Oregon State University TRIGA reactor (OSTR) is used to support a broad range of traditional academic disciplines, including anthropology, oceanography, geology, physics, nuclear chemistry, and nuclear engineering. However, it also finds extensive application in the somewhat more unique area of health physics education and research. This paper summarizes these health physics applications and briefly describes how the OSTR makes important educational contributions to the field of health physics

Physical modelling of the composting environment: A review. Part 1: Reactor systems

International Nuclear Information System (INIS)

Mason, I.G.; Milke, M.W.

2005-01-01

In this paper, laboratory- and pilot-scale reactors used for investigation of the composting process are described and their characteristics and application reviewed. Reactor types were categorised by the present authors as fixed-temperature, self-heating, controlled temperature difference and controlled heat flux, depending upon the means of management of heat flux through vessel walls. The review indicated that fixed-temperature reactors have significant applications in studying reaction rates and other phenomena, but may self-heat to higher temperatures during the process. Self-heating laboratory-scale reactors, although inexpensive and uncomplicated, were shown to typically suffer from disproportionately large losses through the walls, even with substantial insulation present. At pilot scale, however, even moderately insulated self-heating reactors are able to reproduce wall losses similar to those reported for full-scale systems, and a simple technique for estimation of insulation requirements for self-heating reactors is presented. In contrast, controlled temperature difference and controlled heat flux laboratory reactors can provide spatial temperature differentials similar to those in full-scale systems, and can simulate full-scale wall losses. Surface area to volume ratios, a significant factor in terms of heat loss through vessel walls, were estimated by the present authors at 5.0-88.0 m 2 /m 3 for experimental composting reactors and 0.4-3.8 m 2 /m 3 for full-scale systems. Non-thermodynamic factors such as compression, sidewall airflow effects, channelling and mixing may affect simulation performance and are discussed. Further work to investigate wall effects in composting reactors, to obtain more data on horizontal temperature profiles and rates of biological heat production, to incorporate compressive effects into experimental reactors and to investigate experimental systems employing natural ventilation is suggested

Integration of Advanced Probabilistic Analysis Techniques with Multi-Physics Models

Energy Technology Data Exchange (ETDEWEB)

Cetiner, Mustafa Sacit; none,; Flanagan, George F. [ORNL; Poore III, Willis P. [ORNL; Muhlheim, Michael David [ORNL

2014-07-30

An integrated simulation platform that couples probabilistic analysis-based tools with model-based simulation tools can provide valuable insights for reactive and proactive responses to plant operating conditions. The objective of this work is to demonstrate the benefits of a partial implementation of the Small Modular Reactor (SMR) Probabilistic Risk Assessment (PRA) Detailed Framework Specification through the coupling of advanced PRA capabilities and accurate multi-physics plant models. Coupling a probabilistic model with a multi-physics model will aid in design, operations, and safety by providing a more accurate understanding of plant behavior. This represents the first attempt at actually integrating these two types of analyses for a control system used for operations, on a faster than real-time basis. This report documents the development of the basic communication capability to exchange data with the probabilistic model using Reliability Workbench (RWB) and the multi-physics model using Dymola. The communication pathways from injecting a fault (i.e., failing a component) to the probabilistic and multi-physics models were successfully completed. This first version was tested with prototypic models represented in both RWB and Modelica. First, a simple event tree/fault tree (ET/FT) model was created to develop the software code to implement the communication capabilities between the dynamic-link library (dll) and RWB. A program, written in C#, successfully communicates faults to the probabilistic model through the dll. A systems model of the Advanced Liquid-Metal Reactor–Power Reactor Inherently Safe Module (ALMR-PRISM) design developed under another DOE project was upgraded using Dymola to include proper interfaces to allow data exchange with the control application (ConApp). A program, written in C+, successfully communicates faults to the multi-physics model. The results of the example simulation were successfully plotted.

International Reactor Physics Experiment Evaluation (IRPhE) Project. IRPhE Handbook - 2017 edition

International Nuclear Information System (INIS)

2017-01-01

The International Reactor Physics Evaluation (IRPhE) Project was initiated as a pilot in 1999 by the Nuclear Energy Agency (NEA) Nuclear Science Committee (NSC). The project was endorsed as an official activity of the NSC in June 2003. While the NEA co-ordinates and administers the IRPhE Project at the international level, each participating country is responsible for the administration, technical direction and priorities of the project within their respective countries. The information and data included in this handbook are available to NEA member countries, to all contributing countries and to others on a case-by-case basis. The IRPhE Project is patterned after the International Criticality Safety Benchmark Evaluation Project (ICSBEP). It closely co-ordinates with the ICSBEP to avoid duplication of efforts and publication of conflicting information. Some benchmark data are applicable to both nuclear criticality safety and reactor physics technology. Some have already been evaluated and published by the ICSBEP, but have been extended to include other types of measurements in addition to the critical configuration. Through this effort, the IRPhE Project will be able to 1) consolidate and preserve the existing worldwide information base; 2) retrieve lost data; 3) identify areas where more data are needed; 4) draw upon the resources of the international reactor physics community to help fill knowledge gaps; 5) identify discrepancies between calculations and experiments due to deficiencies in reported experimental data, cross-section data, cross-section processing codes and neutronics codes; 6) eliminate a large amount of redundant research and processing of reactor physics experiment data, and 7) improve future experimental planning, execution and reporting. This handbook contains reactor physics benchmark specifications that have been derived from experiments performed at nuclear facilities around the world. The benchmark specifications are intended for use by

Reactor physics special problem in 11. ENFIR

International Nuclear Information System (INIS)

Leszczynski, Francisco

1997-01-01

In this report, the computation method and the results of the work performed of the special topic on reactor physics proposed for the 11. ENFIR is presented. MCNP 4.2 has been adopted as the only code to perform the calculations. The full core of the IPEN-MB-1 critical unit has been modelled without important approximations. The specifications given by the Organizer Commission of the Special Topic were followed. The nuclear libraries adopted were those included on the MCNPDAT package, mainly from ENDF/B-V, except indium data, not included in this package. For indium, data obtained from LANL, based on ENDF/B-VI were used. The results are: critical position of the control banks assuming simultaneous movement: percent of extraction: (49±1)% ; excess of reactivity of the core: ρ =( 3590 ±50)pcm ; total reactivity of the one control rod bank: ρ= (4000±50) pcm. The reactivity curve of the control rods is included also. (author)

Status Report on Scoping Reactor Physics and Sensitivity/Uncertainty Analysis of LR-0 Reactor Molten Salt Experiments

Energy Technology Data Exchange (ETDEWEB)

Brown, Nicholas R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Reactor and Nuclear Systems Division; Mueller, Donald E. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Reactor and Nuclear Systems Division; Patton, Bruce W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Reactor and Nuclear Systems Division; Powers, Jeffrey J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Reactor and Nuclear Systems Division

2016-08-31

Experiments are being planned at Research Centre Rež (RC Rež) to use the FLiBe (2 ⁷LiF-BeF₂) salt from the Molten Salt Reactor Experiment (MSRE) to perform reactor physics measurements in the LR-0 low power nuclear reactor. These experiments are intended to inform on neutron spectral effects and nuclear data uncertainties for advanced reactor systems utilizing FLiBe salt in a thermal neutron energy spectrum. Oak Ridge National Laboratory (ORNL) is performing sensitivity/uncertainty (S/U) analysis of these planned experiments as part of the ongoing collaboration between the United States and the Czech Republic on civilian nuclear energy research and development. The objective of these analyses is to produce the sensitivity of neutron multiplication to cross section data on an energy-dependent basis for specific nuclides. This report provides a status update on the S/U analyses of critical experiments at the LR-0 Reactor relevant to fluoride salt-cooled high temperature reactor (FHR) and liquid-fueled molten salt reactor (MSR) concepts. The S/U analyses will be used to inform design of FLiBe-based experiments using the salt from MSRE.

Status Report on Scoping Reactor Physics and Sensitivity/Uncertainty Analysis of LR-0 Reactor Molten Salt Experiments

International Nuclear Information System (INIS)

Brown, Nicholas R.; Mueller, Donald E.; Patton, Bruce W.; Powers, Jeffrey J.

2016-01-01

Experiments are being planned at Research Centre Rež (RC Rež) to use the FLiBe (2 "7LiF-BeF_2) salt from the Molten Salt Reactor Experiment (MSRE) to perform reactor physics measurements in the LR-0 low power nuclear reactor. These experiments are intended to inform on neutron spectral effects and nuclear data uncertainties for advanced reactor systems utilizing FLiBe salt in a thermal neutron energy spectrum. Oak Ridge National Laboratory (ORNL) is performing sensitivity/uncertainty (S/U) analysis of these planned experiments as part of the ongoing collaboration between the United States and the Czech Republic on civilian nuclear energy research and development. The objective of these analyses is to produce the sensitivity of neutron multiplication to cross section data on an energy-dependent basis for specific nuclides. This report provides a status update on the S/U analyses of critical experiments at the LR-0 Reactor relevant to fluoride salt-cooled high temperature reactor (FHR) and liquid-fueled molten salt reactor (MSR) concepts. The S/U analyses will be used to inform design of FLiBe-based experiments using the salt from MSRE.

Evaluation of the HTR-10 Reactor as a Benchmark for Physics Code QA

International Nuclear Information System (INIS)

William K. Terry; Soon Sam Kim; Leland M. Montierth; Joshua J. Cogliati; Abderrafi M. Ougouag

2006-01-01

The HTR-10 is a small (10 MWt) pebble-bed research reactor intended to develop pebble-bed reactor (PBR) technology in China. It will be used to test and develop fuel, verify PBR safety features, demonstrate combined electricity production and co-generation of heat, and provide experience in PBR design, operation, and construction. As the only currently operating PBR in the world, the HTR-10 can provide data of great interest to everyone involved in PBR technology. In particular, if it yields data of sufficient quality, it can be used as a benchmark for assessing the accuracy of computer codes proposed for use in PBR analysis. This paper summarizes the evaluation for the International Reactor Physics Experiment Evaluation Project (IRPhEP) of data obtained in measurements of the HTR-10's initial criticality experiment for use as benchmarks for reactor physics codes

Computer modelling of water reactor fuel element performance and life time

International Nuclear Information System (INIS)

Bibilashvili, Yu.K.; Golovnin, I.S.; Elesin, V.F.

1983-01-01

Well calibrated models and methods of calculation permit the confident prediction of fuel element behaviour under most different operational conditions; based on the prediction of this kind one can improve designs and fuel element behaviour. Therefore, in the Soviet Union in the development of reactor cores for NPP one of the leading parts is given to design problems associated with computer modelling of fuel element performance and reliability. Special attention is paid to methods of calculation that permit the prediction of fuel element behaviour under conditions which either make experimental studies very complicated (practically impossible) or require laborious and expensive in-pile tests. Primarily it concerns accidents of different types, off-normal conditions, transients, fuel element behaviour at high burn-up, when an accumulation of a great amount of fission fragments is accompanied by changes in physical and mechanical properties as induced by irradiation damage, mechanical fatigue, physical and chemical reactions with a coolant, fission products etc. Some major computer modelling programs for the prediction of water reactor fuel behaviour are briefly described below and tendencies in the further development of work in this area are summarized

Methodology for reactor core physics analysis - part 2

International Nuclear Information System (INIS)

Ponzoni Filho, P.; Fernandes, V.B.; Lima Bezerra, J. de; Santos, T.I.C.

1992-12-01

The computer codes used for reactor core physics analysis are described. The modifications introduced in the public codes and the technical basis for the codes developed by the FURNAS utility are justified. An evaluation of the impact of these modifications on the parameter involved in qualifying the methodology is included. (F.E.). 5 ref, 7 figs, 5 tabs

microRNA 126 inhibits the transition of endothelial progenitor cells to mesenchymal cells via the PIK3R2-PI3K/Akt signalling pathway.

Science.gov (United States)

Zhang, Junfeng; Zhang, Zongqi; Zhang, David Y; Zhu, Jianbing; Zhang, Tiantian; Wang, Changqian

2013-01-01

Endothelial progenitor cells (EPCs) are capable of proliferating and differentiating into mature endothelial cells, and they have been considered as potential candidates for coronary heart disease therapy. However, the transition of EPCs to mesenchymal cells is not fully understood. This study aimed to explore the role of microRNA 126 (miR-126) in the endothelial-to-mesenchymal transition (EndMT) induced by transforming growth factor beta 1 (TGFβ1). EndMT of rat bone marrow-derived EPCs was induced by TGFβ1 (5 ng/mL) for 7 days. miR-126 expression was depressed in the process of EPC EndMT. The luciferase reporter assay showed that the PI3K regulatory subunit p85 beta (PIK3R2) was a direct target of miR-126 in EPCs. Overexpression of miR-126 by a lentiviral vector (lenti-miR-126) was found to downregulate the mRNA expression of mesenchymal cell markers (α-SMA, sm22-a, and myocardin) and to maintain the mRNA expression of progenitor cell markers (CD34, CD133). In the cellular process of EndMT, there was an increase in the protein expression of PIK3R2 and the nuclear transcription factors FoxO3 and Smad4; PI3K and phosphor-Akt expression decreased, a change that was reversed markedly by overexpression of miR-126. Furthermore, knockdown of PIK3R2 gene expression level showed reversed morphological changes of the EPCs treated with TGFβ1, thereby giving the evidence that PIK3R2 is the target gene of miR-126 during EndMT process. These results show that miR-126 targets PIK3R2 to inhibit EPC EndMT and that this process involves regulation of the PI3K/Akt signalling pathway. miR-126 has the potential to be used as a biomarker for the early diagnosis of intimal hyperplasia in cardiovascular disease and can even be a therapeutic tool for treating cardiovascular diseases mediated by the EndMT process.

Research on physical and chemical parameters of coolant in Light-Water Reactors

Energy Technology Data Exchange (ETDEWEB)

Reis, Isabela C.; Mesquita, Amir Z., E-mail: icr@cdtn.br, E-mail: amir@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEM-MG), Belo Horizonte, MG (Brazil)

2015-07-01

The coolant radiochemical monitoring of light-water reactors, both power reactor as research reactors is one most important tasks of the system safe operation. The last years have increased the interest in the coolant chemical studying to optimize the process, to minimize the corrosion, to ensure the primary system materials integrity, and to reduce the workers exposure radiation. This paper has the objective to present the development project in Nuclear Technology Development Center (CDTN), which aims to simulate the primary water physical-chemical parameters of light-water-reactors (LWR). Among these parameters may be cited: the temperature, the pressure, the pH, the electric conductivity, and the boron concentration. It is also being studied the adverse effects that these parameters can result in the reactor integrity. The project also aims the mounting of a system to control and monitoring of temperature, electric conductivity, and pH of water in the Installation of Test in Accident Conditions (ITCA), located in the Thermal-Hydraulic Laboratory at CDTN. This facility was widely used in the years 80/90 for commissioning of several components that were installed in Angra 2 containment. In the test, the coolant must reproduce the physical and chemical conditions of the primary. It is therefore fundamental knowledge of the main control parameters of the primary cooling water from PWR reactors. Therefore, this work is contributing, with the knowledge and the reproduction with larger faithfulness of the reactors coolant in the experimental circuits. (author)

NURESIM lecture on reactor physics (visual aids)

International Nuclear Information System (INIS)

Nguyen Tien Nguyen

1998-01-01

The purpose of the NURESIM software (NUclear REactor SIMulation) is to be used as a computer guide in quick view of the texts and pictures in the fields of nuclear reactor physics. This software is designed so that it can be used by users of different knowledge levels. Students could find here elementary concepts, researchers - important calculation codes as GRACE, PEACO, THERMOS, HEX120. The NURESIM software is composed of four parts: units, pictures, simulations and calculations. In the terminology of IAEA-TECDOC-314 (1984) the first three parts may be classified as a level 2 of sophistication IFM code package: ''Code package useful as a first introduction for nuclear engineers''. The last one (calculations) is classified as a level higher. Details about each part are explained in Paragraph 2. A users guide is in Paragraph 3. (author)

Method of experimental and theoretical modeling for multiple pressure tube rupture for RBMK reactor

International Nuclear Information System (INIS)

Medvedeva, N.Y.; Goldstein, R.V.; Burrows, J.A.

2001-01-01

The rupture of single RBMK reactor channels has occurred at a number of stations with a variety of initiating events. It is assumed in RBMK Safety Cases that the force of the escaping fluid will not cause neighbouring channels to break. This assumption has not been justified. A chain reaction of tube breaks could over-pressurise the reactor cavity leading to catastrophic failure of the containment. To validate the claims of the RBMK Safety Cases the Electrogorsk Research and Engineering Centre, in participation with experts from the Institute of Mechanics of RAS, has developed the method of interacting multiscale physical and mathematical modelling for coupled thermophysical, hydrogasodynamic processes and deformation and break processes causing and (or) accompanying potential failures, design and beyond the design RBMK reactor accidents. To realise the method the set of rigs, physical and mathematical models and specialized computer codes are under creation. This article sets out an experimental philosophy and programme for achieving this objective to solve the problem of credibility or non-credibility for multiple fuel channel rupture in RBMK.(author)

Development of a compact digital reactivity meter and a reactor physics data processor

International Nuclear Information System (INIS)

Shimazu, Y.; Nakano, Y.; Tahara, Y.; Okayama, T.

1987-01-01

Reactor physics tests at initial startup and after refuelings are performed to verify the nuclear design and to assure safe operation. Analog computers and instruments are widely used for the acquisition of data, and these data are reduced by hand. These conventional procedures, however, require much time and labor. Since there has been great progress in the development of digital computers and devices, these procedures are digitalized, which successfully reduces the time and labor required for reactor physics tests

Progress report on research and development in 1991, Institute of Neutron Physics and Reactor Engineering, KfK

International Nuclear Information System (INIS)

1992-03-01

Progress report on research and development in 1991 Institute of Neutron Physics and Reactor Engineering. The Institute of Neutron Physics and Reactor Engineering is concerned with research work in the field of nuclear engineering related to the safety of fast and thermal reactors as well as with specific problems of fusion reactor technology. Under the project of nuclear safety research, the Institute works on concepts designed to drastically improve reactor safety. Apart from that, methods to estimate and minimize the radiological consequences of reactor accidents are developed. Under the fusion technology project, the Institute deals with neutron physics and technological questions of the breeding blanket. Basic research covers technico-physical questions of the interaction between light ion radiation of a high energy density and matter. In addition and to a small extent, questions of employing hydrogen in the transport area are studied. For all these tasks it is indispensable to use up-to-date data processing methods and equipment, from the highest capacity computer to the integrated minicomputer system. (orig./DG) [de

PEBBLES: A COMPUTER CODE FOR MODELING PACKING, FLOW AND RECIRCULATIONOF PEBBLES IN A PEBBLE BED REACTOR

Energy Technology Data Exchange (ETDEWEB)

Joshua J. Cogliati; Abderrafi M. Ougouag

2006-10-01

A comprehensive, high fidelity model for pebble flow has been developed and embodied in the PEBBLES computer code. In this paper, a description of the physical artifacts included in the model is presented and some results from using the computer code for predicting the features of pebble flow and packing in a realistic pebble bed reactor design are shown. The sensitivity of models to various physical parameters is also discussed.

Advanced Mesh-Enabled Monte carlo capability for Multi-Physics Reactor Analysis

Energy Technology Data Exchange (ETDEWEB)

Wilson, Paul; Evans, Thomas; Tautges, Tim

2012-12-24

This project will accumulate high-precision fluxes throughout reactor geometry on a non- orthogonal grid of cells to support multi-physics coupling, in order to more accurately calculate parameters such as reactivity coefficients and to generate multi-group cross sections. This work will be based upon recent developments to incorporate advanced geometry and mesh capability in a modular Monte Carlo toolkit with computational science technology that is in use in related reactor simulation software development. Coupling this capability with production-scale Monte Carlo radiation transport codes can provide advanced and extensible test-beds for these developments. Continuous energy Monte Carlo methods are generally considered to be the most accurate computational tool for simulating radiation transport in complex geometries, particularly neutron transport in reactors. Nevertheless, there are several limitations for their use in reactor analysis. Most significantly, there is a trade-off between the fidelity of results in phase space, statistical accuracy, and the amount of computer time required for simulation. Consequently, to achieve an acceptable level of statistical convergence in high-fidelity results required for modern coupled multi-physics analysis, the required computer time makes Monte Carlo methods prohibitive for design iterations and detailed whole-core analysis. More subtly, the statistical uncertainty is typically not uniform throughout the domain, and the simulation quality is limited by the regions with the largest statistical uncertainty. In addition, the formulation of neutron scattering laws in continuous energy Monte Carlo methods makes it difficult to calculate adjoint neutron fluxes required to properly determine important reactivity parameters. Finally, most Monte Carlo codes available for reactor analysis have relied on orthogonal hexahedral grids for tallies that do not conform to the geometric boundaries and are thus generally not well

Proceedings of 2. Yugoslav symposium on reactor physics, Part 1, Herceg Novi (Yugoslavia), 27-29 Sep 1966

International Nuclear Information System (INIS)

1966-01-01

This Volume 1 of the Proceedings of 2. Yugoslav symposium on reactor physics includes nine papers dealing with the following topics: reactor kinetics, reactor noise, neutron detection, methods for calculating neutron flux spatial and time dependence in the reactor cores of both heavy and light water moderated experimental reactors, calculation of reactor lattice parameters, reactor instrumentation, reactor monitoring systems; measuring methods of reactor parameters; reactor experimental facilities

Physics design of an ultra-long pulsed tokamak reactor

International Nuclear Information System (INIS)

Ogawa, Y.; Inoue, N.; Wang, J.; Yamamoto, T.; Okano, K.

1993-01-01

A pulsed tokamak reactor driven only by inductive current drive has recently revived, because the non-inductive current drive efficiency seems to be too low to realize a steady-state tokamak reactor with sufficiently high energy gain Q. Essential problems in pulsed operation mode is considered to be material fatigue due to cyclic operation and expensive energy storage system to keep continuous electric output during a dwell time. To overcome these problems, we have proposed an ultra-long pulsed tokamak reactor called IDLT (abbr. Inductively operated Day-Long Tokamak), which has the major and minor radii of 10 m and 1.87 m, respectively, sufficiently to ensure the burning period of about ten hours. Here we discuss physical features of inductively operated tokamak plasmas, employing the similar constraints with ITER CDA design for engineering issues. (author) 9 refs., 2 figs., 1 tab

Reactor physical experimental program EROS in the frame of the molten salt applying reactor concepts development