Mutation and genomic amplification of the PIK3CA proto-oncogene in pituitary adenomas

Energy Technology Data Exchange (ETDEWEB)

Murat, C.B.; Braga, P.B.S.; Fortes, M.A.H.Z. [Laboratório de Endocrinologia Celular e Molecular (LIM-25), Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil); Bronstein, M.D. [Unidade de Neuroendocrinologia, Serviço de Endocrinologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil); Corrêa-Giannella, M.L.C.; Giorgi, R.R. [Laboratório de Endocrinologia Celular e Molecular (LIM-25), Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil)

2012-07-13

The tumorigenesis of pituitary adenomas is poorly understood. Mutations of the PIK3CA proto-oncogene, which encodes the p110-α catalytic subunit of PI3K, have been reported in various types of human cancers regarding the role of the gene in cell proliferation and survival through activation of the PI3K/Akt signaling pathway. Only one Chinese study described somatic mutations and amplification of the PIK3CA gene in a large series of pituitary adenomas. The aim of the present study was to determine genetic alterations of PIK3CA in a second series that consisted of 33 pituitary adenomas of different subtypes diagnosed by immunohistochemistry: 6 adrenocorticotropic hormone-secreting microadenomas, 5 growth hormone-secreting macroadenomas, 7 prolactin-secreting macroadenomas, and 15 nonfunctioning macroadenomas. Direct sequencing of exons 9 and 20 assessed by qPCR was employed to investigate the presence of mutations and genomic amplification defined as a copy number ≥4. Previously identified PIK3CA mutations (exon 20) were detected in four cases (12.1%). Interestingly, the Chinese study reported mutations only in invasive tumors, while we found a PIK3CA mutation in one noninvasive corticotroph microadenoma. PIK3CA amplification was observed in 21.2% (7/33) of the cases. This study demonstrates the presence of somatic mutations and amplifications of the PIK3CA gene in a second series of pituitary adenomas, corroborating the previously described involvement of the PI3K/Akt signaling pathway in the tumorigenic process of this gland.

Burnable absorber for the PIK reactor

International Nuclear Information System (INIS)

Gostev, V.V.; Smolskii, S.L.; Tchmshkyan, D.V.; Zakharov, A.S.; Zvezdkin, V.S.; Konoplev, K.A.

1998-01-01

In the reactor PIK design a burnable absorber is not used and the cycle duration is limited by the rods weight. Designed cycle time is two weeks and seams to be not enough for the 100 MW power research reactor equipped by many neutron beams and experimental facilities. Relatively frequent reloading reduces the reactor time on full power and in this way increases the maintenance expenses. In the reactor core fuel elements well mastered by practice are used and its modification was not approved. We try to find the possibilities of installation in the core separate burnable elements to avoid poison of the fuel. It is possible to replace a part of the fuel elements by absorbers, since the fuel elements are relatively small (diameter 5.15mm, uranium 235 content 7.14g) and there are more then 3800 elements in the core. Nevertheless, replacing decreases the fuel burnup and its consumption. In the PIK fuel assembles a little part of the volume is occupied by the dumb elements to create a complete package of the assembles shroud, that is necessary in the hydraulic reasons. In the presented report the assessment of such a replacement is done. As a burnable material Gadolinium was selected. The measurements or the beginning of cycle were performed on the critical facility PIK. The burning calculation was confirmed by measurements on the 18MW reactor WWR-M. The results give the opportunity to twice the cycle duration. The proposed modification of the fuel assembles does not lead to alteration in the other reactor systems, but it touch the burned fuel reprocessing technology. (author)

Expression of activated PIK3CA in ovarian surface epithelium results in hyperplasia but not tumor formation.

Directory of Open Access Journals (Sweden)

Shun Liang

Full Text Available The Phosphatidylinositol 3'-kinase is a key regulator in various cancer-associated signal transduction pathways. Genetic alterations of its catalytic subunit alpha, PIK3CA, have been identified in ovarian cancer. Our in vivo data suggests that PIK3CA activation is one of the early genetic events in ovarian cancer. However, its role in malignant transformation of ovarian surface epithelium (OSE is largely unclear.Using the Müllerian inhibiting substance type II receptor (MISIIR promoter, we generated transgenic mice that expressed activated PIK3CA in the Müllerian epithelium. Overexpression of PIK3CA in OSE induced remarkable hyperplasia, but was not able to malignantly transform OSE in vivo. The consistent result was also observed in primary cultured OSEs. Although enforced expression of PIK3CA could not induce OSE anchorage-independent growth, it significantly increased anchorage-independent growth of OSE transformed by mutant K-ras.While PIK3CA activation may not be able to initiate OSE transformation, we conclude that activation of PIK3CA may be an important molecular event contributing to the maintenance of OSE transformation initiated by oncogenes such as K-ras.

Analysis of PIK3CA Mutations and Activation Pathways in Triple Negative Breast Cancer.

Directory of Open Access Journals (Sweden)

Paolo Cossu-Rocca

Full Text Available Triple Negative Breast Cancer (TNBC accounts for 12-24% of all breast carcinomas, and shows worse prognosis compared to other breast cancer subtypes. Molecular studies demonstrated that TNBCs are a heterogeneous group of tumors with different clinical and pathologic features, prognosis, genetic-molecular alterations and treatment responsivity. The PI3K/AKT is a major pathway involved in the regulation of cell survival and proliferation, and is the most frequently altered pathway in breast cancer, apparently with different biologic impact on specific cancer subtypes. The most common genetic abnormality is represented by PIK3CA gene activating mutations, with an overall frequency of 20-40%. The aims of our study were to investigate PIK3CA gene mutations on a large series of TNBC, to perform a wider analysis on genetic alterations involving PI3K/AKT and BRAF/RAS/MAPK pathways and to correlate the results with clinical-pathologic data.PIK3CA mutation analysis was performed by using cobas® PIK3CA Mutation Test. EGFR, AKT1, BRAF, and KRAS genes were analyzed by sequencing. Immunohistochemistry was carried out to identify PTEN loss and to investigate for PI3K/AKT pathways components.PIK3CA mutations were detected in 23.7% of TNBC, whereas no mutations were identified in EGFR, AKT1, BRAF, and KRAS genes. Moreover, we observed PTEN loss in 11.3% of tumors. Deregulation of PI3K/AKT pathways was revealed by consistent activation of pAKT and p-p44/42 MAPK in all PIK3CA mutated TNBC.Our data shows that PIK3CA mutations and PI3K/AKT pathway activation are common events in TNBC. A deeper investigation on specific TNBC genomic abnormalities might be helpful in order to select patients who would benefit from current targeted therapy strategies.

Analysis of PIK3CA Mutations and Activation Pathways in Triple Negative Breast Cancer.

Science.gov (United States)

Cossu-Rocca, Paolo; Orrù, Sandra; Muroni, Maria Rosaria; Sanges, Francesca; Sotgiu, Giovanni; Ena, Sara; Pira, Giovanna; Murgia, Luciano; Manca, Alessandra; Uras, Maria Gabriela; Sarobba, Maria Giuseppina; Urru, Silvana; De Miglio, Maria Rosaria

2015-01-01

Triple Negative Breast Cancer (TNBC) accounts for 12-24% of all breast carcinomas, and shows worse prognosis compared to other breast cancer subtypes. Molecular studies demonstrated that TNBCs are a heterogeneous group of tumors with different clinical and pathologic features, prognosis, genetic-molecular alterations and treatment responsivity. The PI3K/AKT is a major pathway involved in the regulation of cell survival and proliferation, and is the most frequently altered pathway in breast cancer, apparently with different biologic impact on specific cancer subtypes. The most common genetic abnormality is represented by PIK3CA gene activating mutations, with an overall frequency of 20-40%. The aims of our study were to investigate PIK3CA gene mutations on a large series of TNBC, to perform a wider analysis on genetic alterations involving PI3K/AKT and BRAF/RAS/MAPK pathways and to correlate the results with clinical-pathologic data. PIK3CA mutation analysis was performed by using cobas® PIK3CA Mutation Test. EGFR, AKT1, BRAF, and KRAS genes were analyzed by sequencing. Immunohistochemistry was carried out to identify PTEN loss and to investigate for PI3K/AKT pathways components. PIK3CA mutations were detected in 23.7% of TNBC, whereas no mutations were identified in EGFR, AKT1, BRAF, and KRAS genes. Moreover, we observed PTEN loss in 11.3% of tumors. Deregulation of PI3K/AKT pathways was revealed by consistent activation of pAKT and p-p44/42 MAPK in all PIK3CA mutated TNBC. Our data shows that PIK3CA mutations and PI3K/AKT pathway activation are common events in TNBC. A deeper investigation on specific TNBC genomic abnormalities might be helpful in order to select patients who would benefit from current targeted therapy strategies.

Reclassification of Theileria annae as Babesia vulpes sp. nov.

Science.gov (United States)

Baneth, Gad; Florin-Christensen, Monica; Cardoso, Luís; Schnittger, Leonhard

2015-04-08

Theileria annae is a tick-transmitted small piroplasmid that infects dogs and foxes in North America and Europe. Due to disagreement on its placement in the Theileria or Babesia genera, several synonyms have been used for this parasite, including Babesia Spanish dog isolate, Babesia microti-like, Babesia (Theileria) annae, and Babesia cf. microti. Infections by this parasite cause anemia, thrombocytopenia, and azotemia in dogs but are mostly subclinical in red foxes (Vulpes vulpes). Furthermore, high infection rates have been detected among red fox populations in distant regions strongly suggesting that these canines act as the parasite's natural host. This study aims to reassess and harmonize the phylogenetic placement and binomen of T. annae within the order Piroplasmida. Four molecular phylogenetic trees were constructed using a maximum likelihood algorithm based on DNA alignments of: (i) near-complete 18S rRNA gene sequences (n = 76 and n = 93), (ii) near-complete and incomplete 18S rRNA gene sequences (n = 92), and (iii) tubulin-beta gene sequences (n = 32) from B. microti and B. microti-related parasites including those detected in dogs and foxes. All phylogenetic trees demonstrate that T. annae and its synonyms are not Theileria parasites but are most closely related with B. microti. The phylogenetic tree based on the 18S rRNA gene forms two separate branches with high bootstrap value, of which one branch corresponds to Babesia species infecting rodents, humans, and macaques, while the other corresponds to species exclusively infecting carnivores. Within the carnivore group, T. annae and its synonyms from distant regions segregate into a single clade with a highly significant bootstrap value corroborating their separate species identity. Phylogenetic analysis clearly shows that T. annae and its synonyms do not pertain to Theileria and can be clearly defined as a separate species. Based on the facts that T. annae and its synonyms have not been

The state of the PIK reactor construction

International Nuclear Information System (INIS)

Konoplev, K.A.

1995-01-01

Principle concepts of the PIK reactor project were stated late in the 60's but its construction was started in 1976. By the year 1986 the initial project was realised by approximately 70% but then, after Chernobyl accident the construction was essentially frozen to adjust the project to the revised nuclear safety regulations. The revised project was approved only in 1990 when the country was on the threshold of serious economic problems. The PIK reactor is a source of neutrons placed in the heavy water reflector. The fuel is uranium-235 (90% enrichment) of total weight 27 kg. Light water is used as moderator and coolant. Design parameters: thermal power is 100 W; thermal neutron flux in the reflector is 1.2x10 15 n/cm 2 s; in the central vertical beam tube is 5x10 15 n/cm 2 s; number of horizontal beam tubes is 10; diameter of beam tubes is 10 cm, with the possibility of replacement with beam tubes up to 25 cm in diameter. The reactor will be equipped with sources of hot, cold, and ultracold neutrons to obtain beams in different intervals of energy spectrum. The low temperature circuit will enable to irradiate samples at helium temperatures. The reactor has three series cooling circuits. Emergency core cooling systems in LOCA are double and in emergency power supply system is triple. The PIK reactor has no single common containment but four separate systems: for pipelines and units of the first circuit, for heavy water reflector, for operating hall, and for experimental beam tubes hall

Mani, Miss Anna Modayil

Indian Academy of Sciences (India)

Home; Fellowship. Fellow Profile. Elected: 1960 Section: Earth & Planetary Sciences. Mani, Miss Anna Modayil A.I.I.Sc., FNA 1971-79; Secretary 1977-79. Date of birth: 23 August 1918. Date of death: 16 August 2001. Specialization: Atmospheric Physics and Instrumentation Last known address: c/o Mr K.T. Chandy, 14, ...

Western armament and tactics in the writings of Anna Komnene

Directory of Open Access Journals (Sweden)

Drašković Marko

2006-01-01

Full Text Available In this work, first we reconstructed and commented the western horseman's armament witch Anna Komnene had known (long spear, cross-bow, chain mail "Norman" shield, solarets. Afterwards, we established that Anne knew four types of western horseman's attack (attack in full gallop, attack from back slow march, attack from flank and three types of their battle formation (strewn formation, congested formation, formation of two columns. Also, we commented Anna's knowledge of western siege engines (battering-ram, tortoise catapult, siege tower; we established that Anne knew five types of western siege tower. In the end, we commented several fragments witch show Anna Komnene's knowledge of the western siege tactics.

Anna-Maria Galojan: jah-liikumisega võivad liituda kõik soovijad / Anna-Maria Galojan ; interv. Ishtvan Ban

Index Scriptorium Estoniae

Galojan, Anna-Maria, 1982-

2003-01-01

Ilmunud ka: Severnoje Poberezhje : Subbota 2. aug. lk. 1. Eesti Euroopa liikumise Ida-Virumaa tugikeskuse piirkondlik koordinaator Anna-Maria Galojan oma organisatsioonist, noorte vabatahtlike tööst

MicroRNA-375 inhibits colorectal cancer growth by targeting PIK3CA

Energy Technology Data Exchange (ETDEWEB)

Wang, Yihui [Department of Colorectal Surgery, The Third Affiliated Hospital of Harbin Medical University, 150 Haping Road, 150081 Harbin (China); Tang, Qingchao [Cancer Center, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, 150086 Harbin (China); Li, Mingqi; Jiang, Shixiong [Department of Colorectal Surgery, The Third Affiliated Hospital of Harbin Medical University, 150 Haping Road, 150081 Harbin (China); Wang, Xishan, E-mail: wxshan12081@163.com [Cancer Center, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, 150086 Harbin (China)

2014-02-07

Highlights: • miR-375 is downregulated in colorectal cancer cell lines and tissues. • miR-375 inhibits colorectal cancer cell growth by targeting PIK3CA. • miR-375 inhibits colorectal cancer cell growth in xenograft nude mice model. - Abstract: Colorectal cancer (CRC) is the second most common cause of death from cancer. MicroRNAs (miRNAs) represent a class of small non-coding RNAs that control gene expression by triggering RNA degradation or interfering with translation. Aberrant miRNA expression is involved in human disease including cancer. Herein, we showed that miR-375 was frequently down-regulated in human colorectal cancer cell lines and tissues when compared to normal human colon tissues. PIK3CA was identified as a potential miR-375 target by bioinformatics. Overexpression of miR-375 in SW480 and HCT15 cells reduced PIK3CA protein expression. Subsequently, using reporter constructs, we showed that the PIK3CA untranslated region (3′-UTR) carries the directly binding site of miR-375. Additionally, miR-375 suppressed CRC cell proliferation and colony formation and led to cell cycle arrest. Furthermore, miR-375 overexpression resulted in inhibition of phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. SiRNA-mediated silencing of PIK3CA blocked the inhibitory effect of miR-375 on CRC cell growth. Lastly, we found overexpressed miR-375 effectively repressed tumor growth in xenograft animal experiments. Taken together, we propose that overexpression of miR-375 may provide a selective growth inhibition for CRC cells by targeting PI3K/Akt signaling pathway.

PIK3CA expression in diffuse large B cell lymphoma tissue and the effect of its knockdown in vitro

Directory of Open Access Journals (Sweden)

Cui W

2017-04-01

Full Text Available Wenli Cui,1–4,* Shutao Zheng,5,6,* Zebing Liu,1–3 Weige Wang,1–3 Ying Cai,1–3 Rui Bi,1–3 Bing Cao,1–3 Xiaoyan Zhou1–3 1Department of Pathology, Shanghai Cancer Center, Fudan University, 2Department of Oncology, Shanghai Medical College, Fudan University, 3Institute of Pathology, Fudan University, Shanghai, 4Department of Pathology, The First Affiliated Hospital of Xinjiang Medical University, 5Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, 6State Key Lab Incubation Base of Xinjiang Major Diseases Research, First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi, People’s Republic of China *These authors contributed equally to this work Abstract: PIK3CA has been extensively investigated from its molecular mechanism perspective and epidemiological association with its mutations in different types of cancers. However, little has been reported regarding the clinicopathological significance of PIK3CA expression in diffuse large B cell lymphoma (DLBCL. In the present study, we investigated the clinicopathological significance of PIK3CA in DLBCL by performing immunohistochemical evaluation of PIK3CA in tissue microarrays consisting of 199 cases of DLBCL. Kaplan–Meier survival analysis was performed to analyze the association between PIK3CA expression and overall prognosis. To further investigate the role of PIK3CA mediated in the proliferation, cell cycle and apoptosis of DLBCL cells, Cell Counting Kit-8 (CCK-8 and flow cytometry assays were carried out in DLBCL cell lines after successful, stable knockdown of PIK3CA using lentiviral short hairpin RNA inference. Our results indicated that although PIK3CA was shown to be extensively expressed in DLBCL, no significant association was observed between PIK3CA expression and clinical outcome or between PIK3CA expression and other clinicopathological parameters, except between performance state (PS

[Revista Annaes de Enfermagem: nurses' publications about pediatrics (1932-1941)].

Science.gov (United States)

Fontes, Aline Silva; Santos, Tânia Cristina Franco; Oliveira, Alexandre Barbosa de

2009-01-01

Historic-social study whose object was the intellectual production of nurses and students about pediatric nursing in the journal Annaes de Enfermagem, in the period 1932-1941. The primary source refers to the issues of the journal Annaes de Enfermagem considering the established time limits for the study, as well as reports and correspondences. The secondary sources are constituted by books, articles, dissertations and thesis on the Brazilian history of nursing. On data analysis it was used the thought of the French sociologist Pierre Bourdieu. The results show that the journal Annaes de Enfermagem published important issues of nursing care to the child and contributed to the visibility of Brazilian nurses among the scientific community.

An integrative genomic and proteomic analysis of PIK3CA, PTEN and AKT mutations in breast cancer

Energy Technology Data Exchange (ETDEWEB)

Stemke-Hale, Katherine; Gonzalez-Angulo, Ana Maria; Lluch, Ana; Neve, Richard M.; Kuo, Wen-Lin; Davies, Michael; Carey, Mark; Hu, Zhi; Guan, Yinghui; Sahin, Aysegul; Symmans, W. Fraser; Pusztai, Lajos; Nolden, Laura K.; Horlings, Hugo; Berns, Katrien; Hung, Mien-Chie; van de Vijver, Marc J.; Valero, Vicente; Gray, Joe W.; Bernards, Rene; Mills, Gordon B.; Hennessy, Bryan T.

2008-05-06

Phosphatidylinositol-3-kinase (PI3K)/AKT pathway aberrations are common in cancer. By applying mass spectroscopy-based sequencing and reverse phase protein arrays to 547 human breast cancers and 41 cell lines, we determined the subtype specificity and signaling effects of PIK3CA, AKT and PTEN mutations, and the effects of PIK3CA mutations on responsiveness to PI3K inhibition in-vitro and on outcome after adjuvant tamoxifen. PIK3CA mutations were more common in hormone receptor positive (33.8%) and HER2-positive (24.6%) than in basal-like tumors (8.3%). AKT1 (1.4%) and PTEN (2.3%) mutations were restricted to hormone receptor-positive cancers with PTEN protein levels also being significantly lower in hormone receptor-positive cancers. Unlike AKT1 mutations, PIK3CA (39%) and PTEN (20%) mutations were more common in cell lines than tumors, suggesting a selection for these but not AKT1 mutations during adaptation to culture. PIK3CA mutations did not have a significant impact on outcome in 166 hormone receptor-positive breast cancer patients after adjuvant tamoxifen. PIK3CA mutations, in comparison with PTEN loss and AKT1 mutations, were associated with significantly less and indeed inconsistent activation of AKT and of downstream PI3K/AKT signaling in tumors and cell lines, and PTEN loss and PIK3CA mutation were frequently concordant, suggesting different contributions to pathophysiology. PTEN loss but not PIK3CA mutations rendered cells sensitive to growth inhibition by the PI3K inhibitor LY294002. Thus, PI3K pathway aberrations likely play a distinct role in the pathogenesis of different breast cancer subtypes. The specific aberration may have implications for the selection of PI3K-targeted therapies in hormone receptor-positive breast cancer.

Uncovering Sundanese Values by Analyzing Symbolic Meaning of Ménak Priangan Clothing (1800-1942)

Science.gov (United States)

Karmila, M.; Suciati; Widiaty, I.

2016-04-01

This study investigates symbolic meanings found in the Sunda ethnic clothing, particularly the Menak Priangan clothing. This study aims to uncover and document those symbolic meanings found in the Menak Priangan clothing as an effort to develop Sunda cultural artefacts of West Java. This study on Menak Priangan clothing applies ethnography (visual) and aesthetic methods. The visual method is utilized in order to uncover local cultural (Sunda) values found in Menak Priangan clothing visualization, including: design, model, name, and representing colours, which then directed towards local Sundanese aesthetic concepts living within the Priangan community. Furthermore, aesthetic method is used to explore role of aesthetic values in empowering visual cultural values within certain community, particularly Sunda aesthetic values. The study results show that since the 19th century, Sunda ethnic clothing was limited to Priangan Sunda only, while traditional clothing wearing by Priangan people reflects their social strata, consisting of: a. Menak Gede (Menak pangluhurna: mayor), bearing raden title, b. Menak Leutik/Santana (mayor assistant), titles: asep, mas, agus, ujang, (Nyimas for woman), c. Somah/Cacah: ordinary people/lower class. Clothing is a cultural phenomenon within certain culture reflecting such society experiences. For Menak people, clothing and its accessories have important meanings. They wear such traditional clothing and accessories as a symbol of power they have within bureaucratic structure and as a symbol of social status they bear within traditional community structure.

Kerjav kunstnik / Anna Hints, Maria Rõhu

Index Scriptorium Estoniae

Hints, Anna, 1982-

2011-01-01

Tallinna Linnagaleriis oli 17.03.-10.04.2011 avatud Anna Hintsi ja Maria Rõhu näitus "Nälg". Autorid näituse taotlusest, raha taotlemisest, aktsioonist "Kerjav kunstnik", külastajate suhtumisest sellesse. Näituse aruanne

Anna-Maria Galojan - värske hääl poliitikas / Anna-Maria Galojan ; interv. Toomas Verrev

Index Scriptorium Estoniae

Galojan, Anna-Maria, 1982-

2007-01-01

Transiidifirma Transgroup Invest arendusdirektor, Eesti Välispoliitika Instituudi töötaja Anna-Maria Galojan, kes kandideerib Riigikogu valimistel Reformierakonna nimekirjas, räägib oma haridusteest, karjäärist ja poliitilistest eesmärkidest

Eluloofilmide põud paneb rääkima Anna Chapmanist / Andres Laasik

Index Scriptorium Estoniae

Laasik, Andres, 1960-2016

2010-01-01

Ameerika ajalehede käivitatud diskussioonist eluloofilmist, mille võiks vändata spiooniafääriga kuulsaks saanud Anna Chapmanist (Anna Kuštšenko). USA-s, Suurbritannias, Indias ja Soomes valmivatest eluloofilmidest. Austraalia filmist "Mao viimane tantsija"

Anna Mani – A Student Remembers

Indian Academy of Sciences (India)

Srimath

Developing an Indian ozonesonde was her pet project, assigned to her by K R Ramanathan, ... Her scientific career began with C V Raman at the Indian Institute of ... Independent India was full of opportunities and Anna Mani seized the ...

Phosphatidyl inositol-3 kinase (PIK3CA) E545K mutation confers cisplatin resistance and a migratory phenotype in cervical cancer cells

Science.gov (United States)

Arjumand, Wani; Merry, Cole D.; Wang, Chen; Saba, Elias; McIntyre, John B.; Fang, Shujuan; Kornaga, Elizabeth; Ghatage, Prafull; Doll, Corinne M.; Lees, Susan P.

2016-01-01

The phosphatidylinositol-3 kinase (PI3K)/Akt/mTOR signaling pathway is activated in many human cancers. Previously, we reported that patients with early stage cervical cancer whose tumours harbour PIK3CA exon 9 or 20 mutations have worse overall survival in response to treatment with radiation and cisplatin than patients with wild-type PIK3CA. The purpose of this study was to determine whether PIK3CA-E545K mutation renders cervical cancer cells more resistant to cisplatin and/or radiation, and whether PI3K inhibition reverses the phenotype. We found that CaSki cells that are heterozygous for the PIK3CA-E545K mutation are more resistant to cisplatin or cisplatin plus radiation than either HeLa or SiHa cells that express only wild-type PIK3CA. Similarly, HeLa cells engineered to stably express PIK3CA-E545K were more resistant to cisplatin or cisplatin plus radiation than cells expressing only wild-type PIK3CA or with PIK3CA depleted. Cells expressing the PIK3CA-E545K mutation also had constitutive PI3K pathway activation and increased cellular migration and each of these phenotypes was reversed by treatment with the PI3K inhibitor GDC-0941/Pictilisib. Our results suggests that cervical cancer patients whose tumours are positive for the PIK3CA-E545K mutation may benefit from PI3K inhibitor therapy in concert with standard cisplatin and radiation therapy. PMID:27489350

Tumor PIK3CA genotype and prognosis in early-stage breast cancer

DEFF Research Database (Denmark)

Zardavas, Dimitrios; Te Marvelde, Luc; Milne, Roger L.

2018-01-01

% in the ER-negative/HER2-negative, HER2-positive, and ER-positive/HER2-negative subtypes, respectively. In univariable analysis, PIK3CA mutations were associated with better IDFS (HR, 0.77; 95% CI, 0.71 to 0.84; P, .001), with evidence for a stronger effect in the first years of follow-up (0 to 5 years: HR...... points. Conclusion In this large pooled analysis, PIK3CA mutations were significantly associated with a better IDFS, DDFS, and OS, but had a lesser prognostic effect after adjustment for other prognostic factors....

Mutant PIK3CA Induces EMT in a Cell Type Specific Manner.

Directory of Open Access Journals (Sweden)

Divya Bhagirath

Full Text Available Breast cancer is characterized into different molecular subtypes, and each subtype is characterized by differential gene expression that are associated with distinct survival outcomes in patients. PIK3CA mutations are commonly associated with most breast cancer subtypes. More recently PIK3CA mutations have been shown to induce tumor heterogeneity and are associated with activation of EGFR-signaling and reduced relapse free survival in basal subtype of breast cancer. Thus, understanding what determines PIK3CA induced heterogeneity and oncogenesis, is an important area of investigation. In this study, we assessed the effect of mutant PIK3CA together with mutant Ras plus mutant p53 on oncogenic behavior of two distinct stem/progenitor breast cell lines, designated as K5+/K19- and K5+/K19+. Constructs were ectopically overexpressed in K5+/K19- and K5+/K19+ stem/progenitor cells, followed by various in-vitro and in-vivo analyses. Oncogene combination m-Ras/m-p53/m-PIK3CA efficiently transformed both K5+/K19- and K5+/K19+ cell lines in-vitro, as assessed by anchorage-independent soft agar colony formation assay. Significantly, while this oncogene combination induced a complete epithelial-to-mesenchymal transition (EMT in K5+/K19- cell line, mostly epithelial phenotype with minor EMT component was seen in K5+/K19+ cell line. However, both K5+/K19- and K5+/K19+ transformed cells exhibited increased invasion and migration abilities. Analyses of CD44 and CD24 expression showed both cell lines had tumor-initiating CD44+/CD24low cell population, however transformed K5+/K19- cells had more proportion of these cells. Significantly, both cell types exhibited in-vivo tumorigenesis, and maintained their EMT and epithelial nature in-vivo in mice tumors. Notably, while both cell types exhibited increase in tumor-initiating cell population, differential EMT phenotype was observed in these cell lines. These results suggest that EMT is a cell type dependent

Highly sensitive detection of the PIK3CAH1047R mutation in colorectal cancer using a novel PCR-RFLP method

International Nuclear Information System (INIS)

Li, Wan-Ming; Hu, Ting-Ting; Zhou, Lin-Lin; Feng, Yi-Ming; Wang, Yun-Yi; Fang, Jin

2016-01-01

The PIK3CA H1047R mutation is considered to be a potential predictive biomarker for EGFR-targeted therapies. In this study, we developed a novel PCR-PFLP approach to detect the PIK3CA H1047R mutation in high effectiveness. A 126-bp fragment of PIK3CA exon-20 was amplified by PCR, digested with FspI restriction endonuclease and separated by 3 % agarose gel electrophoresis for the PCR-RFLP analysis. The mutant sequence of the PIK3CA H1047R was spiked into the corresponding wild-type sequence in decreasing ratios for sensitivity analysis. Eight-six cases of formalin-fixed paraffin-embedded colorectal cancer (CRC) specimens were subjected to PCR-RFLP to evaluate the applicability of the method. The PCR-RFLP method had a capability to detect as litter as 0.4 % of mutation, and revealed 16.3 % of the PIK3CA H1047R mutation in 86 CRC tissues, which was significantly higher than that discovered by DNA sequencing (9.3 %). A positive association between the PIK3CA H1047R mutation and the patients’ age was first found, except for the negative relationship with the degree of tumor differentiation. In addition, the highly sensitive detection of a combinatorial mutation of PIK3CA, KRAS and BRAF was achieved using individual PCR-RFLP methods. We developed a sensitive, simple and rapid approach to detect the low-abundance PIK3CA H1047R mutation in real CRC specimens, providing an effective tool for guiding cancer targeted therapy

Assessing PIK3CA and PTEN in Early-Phase Trials with PI3K/AKT/mTOR Inhibitors

Directory of Open Access Journals (Sweden)

Filip Janku

2014-01-01

Full Text Available Despite a wealth of preclinical studies, it is unclear whether PIK3CA or phosphatase and tensin homolog (PTEN gene aberrations are actionable in the clinical setting. Of 1,656 patients with advanced, refractory cancers tested for PIK3CA or PTEN abnormalities, PIK3CA mutations were found in 9% (146/1,589, and PTEN loss and/or mutation was found in 13% (149/1,157. In multicovariable analysis, treatment with a phosphatidylinositol 3-kinase (PI3K/AKT/mammalian target of rapamycin (mTOR inhibitor was the only independent factor predicting response to therapy in individuals harboring a PIK3CA or PTEN aberration. The rate of stable disease ≥6 months/partial response reached 45% in a subgroup of individuals with H1047R PIK3CA mutations. Aberrations in the PI3K/AKT/mTOR pathway are common and potentially actionable in patients with diverse advanced cancers. This work provides further important clinical validation for continued and accelerated use of biomarker-driven trials incorporating rational drug combinations.

Highly frequent promoter methylation and PIK3CA amplification in non-small cell lung cancer (NSCLC)

International Nuclear Information System (INIS)

Ji, Meiju; Guan, Haixia; Gao, Cuixia; Shi, Bingyin; Hou, Peng

2011-01-01

Lung cancer is the leading cause of cancer-related death worldwide. Genetic and epigenetic alterations have been identified frequently in lung cancer, such as promoter methylation, gene mutations and genomic amplification. However, the interaction between genetic and epigenetic events and their significance in lung tumorigenesis remains poorly understood. We determined the promoter methylation of 6 genes and PIK3CA amplification using quantitative methylation-specific PCR (Q-MSP) and real-time quantitative PCR, respectively, and explore the association of promoter methylation with PIK3CA amplification in a large cohort of clinically well-characterized non-small cell lung cancer (NSCLC). Highly frequent promoter methylation was observed in NSCLC. With 100% diagnostic specificity, excellent sensitivity, ranging from 45.8 to 84.1%, was found for each of the 6 genes. The promoter methylation was associated with histologic type. Methylation of CALCA, CDH1, DAPK1, and EVX2 was more common in squamous cell carcinomas (SCC) compared to adenocarcinomas (ADC). Conversely, there was a trend toward a higher frequency of RASSF1A methylation in ADC than SCC. In addition, PIK3CA amplification was frequently found in NSCLC, and was associated with certain clinicopathologic features, such as smoking history, histologic type and pleural indentation. Importantly, aberrant promoter methylation of certain genes was significantly associated with PIK3CA amplification. Our data showed highly frequent promoter methylation and PIK3CA amplification in Chinese NSCLC population, and first demonstrated the associations of gene methylation with PIK3CA amplification, suggesting that these epigenetic events may be a consequence of overactivation of PI3K/Akt pathway

Imperatrix Bulgariae Anna-Neda (1277-c.1346

Directory of Open Access Journals (Sweden)

Gjuzelev Vassil

2013-01-01

Full Text Available Si è fato il tentanivo di presentare dettagliatamente la vita di Anna-Neda, la celebre imperatrice bulgara di origine serba. Si è ribadito sulle sue attività e le relazioni con vari personaggi dell’epoca a partire dal matrimonio con Michail III Šišman Asen, despota di Vidin, fino alla morte di lei, probabilmente avvenuta nel 1346 a Dubrovnik. Parole chiave: Impero bulgaro, Vidin, Tǎrnovo, Regno di Napoli. In this article an effort is made to present in detail the life of Anna-Neda, famous Bulgarian empress of Serbian origine. The accent is put on her activities and relations with various characters from the period after her marriage with Michail III Asen Šišman, despot of Vidin, until her death, which probably occurred in 1346 in Dubrovnik.

SANA - project results and PIK contributions

Energy Technology Data Exchange (ETDEWEB)

Bellmann, K; Erhard, M; Flechsig, M; Grote, R; Suckow, F

1998-03-01

This report includes the final project results of the two groups at PIK, involved in the project: Firstly, the newly developed physiologically-based forest growth model FORSANA was applied for the first time to three pine stands, which differed largely in their air pollution and deposition history. (The evaluation of the model is presented in PIK Report 32). The model was able to explain the growth during the last decades of at least two of the three stands from the climatic and deposition conditions at the sites. The third site was shown to be exceptional with respect to its relation between dimension and age, and was supposed to be exposed to major disturbances in the past, which could not be accounted for by the model. To extrapolate from the stand level to the regional level, FORSANA was initialised with spatially explicit data from forestry inventory and soil maps. Simulations were executed with measured weather records and regional distributions of deposition and air pollution, which were estimated on the basis of emission inventories and wind directions. Different assumptions about the development of air pollution had been applied to investigate different pollution abatement strategies. The results showed that a positive effect can be expected from the actual emission reductions close the main centres of emission, but showed also that this effect is decreasing with increasing distance from the emission source. (orig./KW)

[Anna Hamilton (1864-1935), the excellence of nursing.

Science.gov (United States)

Diebolt, Évelyne

2017-12-01

A Frenchwoman, Anna Hamilton (1864-1935), daughter of a Franco-English couple, reads with passion the works of Florence Nightingale and takes an interest in nursing. In order to practice it, she first passes the equivalent of a bachelor’s degree in self-education and registers at the Marseille medical school. She wants to prepare a medical thesis on the nursing staff in the hospitals in Europe and is conducting an investigation throughout Europe. She passed her thesis on June 15, 1900 entitled “Considerations on hospital nurses”. This work is immediately published. That same year, she took up a post at the “Maison de santé protestante” in Bordeaux (MSP), founded in 1863. Without managerial staff, she is forced to recruit them abroad. She publishes a professional journal : “La Garde-Malade hospitalière” (1906-1914). Then the war turned the MSP into a military hospital, but the institution continued to receive local paying patients. She was given permission to call the school of nurses : Florence Nightingale School. Anna Hamilton is working with American women to create a medical and social service in Aisne. A graduate, Antoinette Hervey, then opened a medical-social service in Rouen, which would employ up to 30 visiting nurses. In 1916, the MSP received a donation from the domain of Bagatelle. The board of directors wants to sell it, but Anna Hamilton manages to finance a hospital-school thanks to families bereaved by the war and a subscription announced in the “Journal of Nursing”. Other establishments created by former students of the MSP opened : the School-hospital Ambroise Paré in Lille, a nursing home for nurses in Chambon-sur-Lignon in 1927 (the Edith-Seltzer foundation) and a sanatorium in Briançon. After a busy life, Anna Hamilton died of cancer in 1935 and is buried in Bordeaux.

A Teacher's Guide for "Anna Karenina."

Science.gov (United States)

WGBH-TV, Boston, MA.

In 1870, after the successful publication of "War and Peace," Leo Tolstoy began imagining a story about a high-born society woman, "Anna Karenina," who destroys her life by having an adulterous affair. By presenting his adulteress as a sympathetic character, Tolstoy aimed to expose injustices in such Russian institutions as…

Clinical findings and normative ocular data for free-living Anna's (Calypte anna) and Black-chinned (Archilochus alexandri) Hummingbirds.

Science.gov (United States)

Moore, Bret A; Maggs, David J; Kim, Soohyun; Motta, Monica J; Bandivadekar, Ruta; Tell, Lisa A; Murphy, Christopher J

2018-02-20

To estimate the prevalence of ocular disease and obtain normative ocular data for free-living hummingbirds. Two hundred and sixty-three free-living, adult Hummingbirds from coastal and inland central California were studied, including Anna's (Calypte anna, n = 186) and Black-chinned (Archilochus alexandri; n = 77) hummingbirds. Slit lamp biomicroscopy and indirect ophthalmoscopy were performed on all individuals. Rebound tonometry, measurement of horizontal palpebral fissure length, and streak retinoscopy were performed on select individuals. Five conscious Anna's Hummingbirds underwent ocular imaging including fundus photography, digital slit lamp photography, and anterior segment and retinal optical coherence tomography. The prevalence of ocular disease in this population was 2.28%. Ocular imaging revealed a thin cornea, shallow anterior chamber, large lens, and a single central, deep convexiclivate fovea. Mean ± SD intraocular pressure was 11.21 ± 2.23 mm Hg. Mean ± SD eyelid length was 2.59 ± 0.19 mm. All eyes were emmetropic or mildly hyperopic with a mean (range) ± SD refractive error of +0.32 (-0.25 to +1) ± 0.33 diopters. Consistent with previous reports, these data suggest that hummingbirds have visual characteristics found in predatory and prey species, as well as a low prevalence of spontaneous ocular disease. This work provides a set of reference values and clinical findings that can be used in the future research on hummingbird vision and ocular disease. It also provides representative diagnostic images of normal birds and demonstrates that advanced ocular imaging can be performed on manually restrained hummingbirds without pharmacologic dilation. © 2018 American College of Veterinary Ophthalmologists.

PIK3CA, HRAS and PTEN in human papillomavirus positive oropharyngeal squamous cell carcinoma

International Nuclear Information System (INIS)

Chiosea, Simion I; Nikiforova, Marina N; Grandis, Jennifer R; Lui, Vivian W Y; Diergaarde, Brenda; Maxwell, Jessica H; Ferris, Robert L; Kim, Seungwon W; Luvison, Alyssa; Miller, Megan

2013-01-01

Recent genomic evidence suggests frequent phosphatidylinositide 3-kinase (PI3K) pathway activation in human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma. Mutations/amplification of the gene encoding p110α catalytic subunit of phosphoinositide 3-kinase (PIK3CA), loss of phosphatase and tensin homolog (PTEN) and HRAS mutations are known to activate PI3K pathway. PIK3CA mutations were identified by Sanger sequencing in 23 of 75 (31%) HPV-positive oropharyngeal carcinomas, including exon 9 (p.E545K [n = 10] and p.E542K [n = 5]) or exon 20 (p.H1047Y, n = 2) mutations. Five rare and one novel (p.R537Q) PIK3CA mutations were identified. HRAS mutation (p.Q61L) was detected in 1 of 62 tested cases. PIK3CA amplification by fluorescence in situ hybridization (FISH) was identified in 4 cases (4/21, 20%), while PTEN loss was seen in 7 (7/21, 33%) cases (chromosome 10 monosomy [n = 4], homozygous deletion [n = 3]). Overall, genetic alterations that likely lead to PI3K pathway activation were identified in 34 of 75 cases (45%) and did not correlate with disease specific survival. These findings offer a molecular rationale for therapeutic targeting of PI3K pathway in patients with HPV-positive oropharyngeal carcinoma

The sensitivity and efficacy method of PIK3CA exon 9 E545A as a high diagnostic accuracy in breast cancer

Directory of Open Access Journals (Sweden)

Desriani

2018-06-01

Full Text Available The phosphatidylinositol 3-kinases (PIK3s are lipid kinases. Mutation in the exon 9 and exon 20 determined as a predictive factor in anti-HER-2 therapy. In some countries, such as Singapore, China, and Peru, PIK3CA exon 9 E545A was reported to produce the highest rate of mutation. In this research, we developed and optimized PIK3CA exon 9 E545A detection methods with intercalating dye SYBR Green I based on the Tm Shift approach by using prepared recombinant plasmid pGEMT-easy PIK3CA exon 9 and PIK3CA exon 9 E545A. Recombinant plasmid was used due to the limited number of samples. Methods: Recombinant plasmid was prepared based on manufactured procedures, and this process was then followed by Tm prediction with Poland software, Tm Shift SYBR Green I development, and its characterization (reproducibility, repeatability, sensitivity, qPCR efficiency, and qPCR amplification, respectively. Result: A method for PIK3CA E545A detection based on TM shift SYBR Green I has been successfully developed. The melting temperature for PIK3CA exon 9 was 78.1 ± 0.1 °C, while that for PIK3CA exon E545A was 80.20 °C. The Tm of mutant was the same as that predicted using Polland Software. The reproducibility of the methods was high, with the coefficient values for inter and intra assays were below 10% with a high sensitivity at 1%, while R2 0.99 and PCR efficiency was 97.75%. Conclusion: The results presented here demonstrate that the PIK3CA exon 9 E545A detection method has a good sensitivity and efficacy assay, which proves that the method has a high diagnostic accuracy in breast cancer. Keywords: SYBR Green I, PIK3CA E545A, Breast cancer, Real time PCR, Recombinant plasmid

Aiamängud vormi ja värviga / Anna-Liisa Unt ; interv. Victoria Parmas

Index Scriptorium Estoniae

Unt, Anna-Liisa, 1982-

2006-01-01

Eesti Maaülikoolis ja Rootsi Põllumajandusülikoolis maastikuarhitektuuri õppinud Anna-Liisa Unt (sünd. 1982) endast, oma aiakujundustest, tüüpilisest eestlase aiast tänapäeval jm. Anna-Liisa Undi tööde loetelu

Eesti goes St. Etienne / Anna Roomet

Index Scriptorium Estoniae

Roomet, Anna

2006-01-01

Näitus Eesti Kunstiakadeemia tootedisaini osakonna magistrantide viimase kahe aasta projektide paremikust esindas Eestit disainibiennaalil St. Etiennis Prantsusmaal. Näituse panid üles Pent Talvet ja Pavel Sidorenko, näitusel osalejad: Anna-Maria Einla, Kätlin Kangur, Triin Kuusler, Andri Laidre, Veiko Liis, Liina-Kai Raivet, P. Sidorenko, P. Talvet, Ingela Viks, Triin Voss

Dietary protein level affects iridescent coloration in Anna's hummingbirds, Calypte anna.

Science.gov (United States)

Meadows, Melissa G; Roudybush, Thomas E; McGraw, Kevin J

2012-08-15

Many animal displays involve colorful ornamental traits that signal an individual's quality as a mate or rival. Brilliant iridescent ornaments are common, but little is currently known about their production cost and signaling value. One potential cost of colorful ornaments is the acquisition of limited dietary resources that may be involved, directly or indirectly, in their production. Protein, the primary component of bird feathers and of many nanostructural components of iridescent traits, is naturally restricted in hummingbird diets (comprised mostly of sugars), suggesting that iridescent coloration may be especially challenging to produce in these animals. In this study, we experimentally investigated the effect of dietary protein availability during molt on iridescent color expression in male Anna's hummingbirds (Calypte anna). We fed captive birds either a 6% (high) or a 3% (low) protein diet and stimulated molt by plucking half the gorget and crown ornaments on each bird as well as the non-ornamental iridescent green tail feathers. We found that birds receiving more protein grew significantly more colorful crown feathers (higher red chroma and redder hue) than those fed the low-protein diet. Diet did not affect gorget coloration, but regrowth of feathers in captivity affected both gorget and crown coloration. Additionally, birds on the high-protein diet grew yellower (higher hue) green tail feathers than birds on the low-protein diet. These results indicate that iridescent ornamental feathers are sensitive to diet quality and may serve as honest signals of nutrition to mates or rivals. Further, because both ornamental and non-ornamental iridescent coloration were affected by conditions during their growth, iridescent color in these birds appears to be generally condition dependent.

[O rzeczach minionych, scripta rerum historicarum annae rutkowska-plachcińska oblata] / Risto Pullat

Index Scriptorium Estoniae

Pullat, Raimo, 1935-

2011-01-01

Arvustus: O rzeczach minionych, scripta rerum historicarum annae rutkowska-plachcińska oblata. (Pod redakeja Marty Mlynarskiej-Kaletynowej i Jerzego Kruppe. Studia i materaly z historii kultury materialney pod redakeja Jerzego Kruppe). Warszawa, 2006. Sisukast ja mitmekülgsest Anna Rutkowska-Plachcinska juubelikogumikust

Seeing things by Anna Margolin

Directory of Open Access Journals (Sweden)

Francuz Aleksandra

2016-12-01

Full Text Available If we recall the most important words for the poetry, we should begin the story with the stones, lily, hands and blood, which, if you look at them with the philological accuracy, are interrelated: situate themselves clearly on opposite banks of the creative process. They talk about the construction of the building consisting of perceptions about their own strength and weakness, ecstasy and congealing in what for centuries the classics poets have tried to fathom: the harmony and clarity, driven by the hope that in life they should above all stick to be beauty. And in addition, they ought to go further than discipline, practice eye and expand the field of view, should not shun from the gusts of the heart, because the heart grows more powerful due to great ideas, passions. Spacious becomes the vision of writing, it is the weave of contradictions - this is how one of the most important twentieth-century poets, who wrote in Yiddish, Anna Margolin sees it. Margolin’s poetry is a clear return towards neoclassicism, building up topics, theses, allusions, ideas taken from ideologically close to her artists of great individuality, Anna Akhmatova (from whom she took her name, Osip Mandelstam, Rainer Maria Rilke, Ezra Pound.

Hovering and forward flight energetics in Anna's and Allen's hummingbirds.

Science.gov (United States)

Clark, Christopher James; Dudley, Robert

2010-01-01

Aerodynamic theory predicts that the mechanical costs of flight are lowest at intermediate flight speeds; metabolic costs of flight should trend similarly if muscle efficiency is constant. We measured metabolic rates for nine Anna's hummingbirds (Calypte anna) and two male Allen's hummingbirds (Selasphorus sasin) feeding during flight from a free-standing mask over a range of airspeeds. Ten of 11 birds exhibited higher metabolic costs during hovering than during flight at intermediate airspeeds, whereas one individual exhibited comparable costs at hovering and during forward flight up to speeds of approximately 7 m s(-1). Flight costs of all hummingbirds increased at higher airspeeds. Relative to Anna's hummingbirds, Allen's hummingbirds exhibited deeper minima in the power curve, possibly due to higher wing loadings and greater associated costs of induced drag. Although feeding at a mask in an airstream may reduce body drag and, thus, the contributions of parasite power to overall metabolic expenditure, these results suggest that hummingbird power curves are characterized by energetic minima at intermediate speeds relative to hovering costs.

Significance of PIK3CA Mutations in Patients with Early Breast Cancer Treated with Adjuvant Chemotherapy: A Hellenic Cooperative Oncology Group (HeCOG Study.

Directory of Open Access Journals (Sweden)

George Papaxoinis

Full Text Available The PI3K-AKT pathway is frequently activated in breast cancer. PIK3CA mutations are most frequently found in the helical (exon 9 and kinase (exon 20 domains of this protein. The aim of the present study was to examine the role of different types of PIK3CA mutations in combination with molecular biomarkers related to PI3K-AKT signaling in patients with early breast cancer.Tumor tissue samples from 1008 early breast cancer patients treated with adjuvant chemotherapy in two similar randomized trials of HeCOG were examined. Tumors were subtyped with immunohistochemistry (IHC and FISH for ER, PgR, Ki67, HER2 and androgen receptor (AR. PIK3CA mutations were analyzed by Sanger sequencing (exon 20 and qPCR (exon 9 (Sanger/qPCR mutations. In 610 cases, next generation sequencing (NGS PIK3CA mutation data were also available. PIK3CA mutations and PTEN protein expression (IHC were analyzed in luminal tumors (ER and/or PgR positive, molecular apocrine carcinomas (MAC; ER/PgR negative / AR positive and hormone receptor (ER/PgR/AR negative tumors.PIK3CA mutations were detected in 235/1008 tumors (23% with Sanger/qPCR and in 149/610 tumors (24% with NGS. Concordance between the two methods was good with a Kappa coefficient of 0.76 (95% CI 0.69-0.82. Lobular histology, low tumor grade and luminal A tumors were associated with helical domain mutations (PIK3CAhel, while luminal B with kinase domain mutations (PIK3CAkin. The overall incidence of PIK3CA mutations was higher in luminal as compared to MAC and hormone receptor negative tumors (p = 0.004. Disease-free and overall survival did not significantly differ with respect to PIK3CA mutation presence and type. However, a statistically significant interaction between PIK3CA mutation status and PTEN low protein expression with regard to prognosis was identified.The present study did not show any prognostic significance of specific PIK3CA mutations in a large group of predominantly lymph-node positive breast cancer

Official portrait of Astronaut Anna L. Fisher

Science.gov (United States)

1985-01-01

Official portrait of Astronaut Anna L. Fisher. Fisher is posing with her helmet on the table in front of her and the American flag appears over the opposite shoulder (34357); Posing with an empty table in front of her and the American flag behind her (34358).

CLOVES syndrome: review of a PIK3CA-related overgrowth spectrum (PROS).

Science.gov (United States)

Martinez-Lopez, A; Blasco-Morente, G; Perez-Lopez, I; Herrera-Garcia, J D; Luque-Valenzuela, M; Sanchez-Cano, D; Lopez-Gutierrez, J C; Ruiz-Villaverde, R; Tercedor-Sanchez, J

2017-01-01

Overgrowth syndromes are characterized by global or localized disproportionate growth associated with other anomalies, including vascular malformations and neurological and/or visceral disorders. CLOVES (Congenital Lipomatous asymmetric Overgrowth of the trunk with lymphatic, capillary, venous, and combined-type Vascular malformations, Epidermal naevi, Scoliosis/Skeletal and spinal anomalies) is an overgrowth syndrome caused by mosaic activating mutation in gene PIK3CA, which gives rise to abnormal PI3K-AKT-mTOR pathway activation. These mutations are responsible for the clinical manifestations of the syndrome, which include low- and high-flow vascular malformations, thoracic lipomatous hyperplasia, asymmetric growth, and visceral and neurological disorders. These common anomalies are illustrated with figures from two personal cases. Identification of the clinical and genetic characteristics of CLOVES syndrome is crucial for the differential diagnosis with other overgrowth syndromes, such as Proteus or Klippel-Trenaunay (K-T) syndromes, and for the therapeutic management of the different anomalies. In this context, a new entity comprising different syndromes with phenotypic mutations in PIK3CA has been proposed, designated PIK3CA-related overgrowth spectrum (PROS), with the aim of facilitating clinical management and establishing appropriate genetic study criteria. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Molecular detection of Theileria annae and Hepatozoon canis in foxes (Vulpes vulpes) in Croatia.

Science.gov (United States)

Dezdek, Danko; Vojta, Lea; Curković, Snjezana; Lipej, Zoran; Mihaljević, Zeljko; Cvetnić, Zeljko; Beck, Relja

2010-09-20

An epizootiological field study on tick-borne protozoan infections in foxes (Vulpes vulpes) was carried out in different parts of Croatia. Spleen samples of 191 carcasses of red foxes killed in sanitary hunting, were examined for the presence of hematozoa by polymerase chain reaction (PCR) and subsequent sequencing. The investigation revealed four species of hematozoa in 57 foxes (30%), namely Theileria annae, Theileria sp. 3182/05 and Hepatozoon canis. T. annae was found in 10 foxes (5%), Theileria sp. 3182/05 in a single animal (1%), H. canis in 44 (23%) and Hepatozoon sp. was detected in two foxes (1%). T. annae and H. canis were distributed through all the studied regions, while Theileria sp. 3182/05 and Hepatozoon sp. were restricted to the Zagreb and Zagorje, and Istria regions, respectively. Detection of T. annae in all regions of Croatia indicates the presence of the natural cycle of the parasite and raises the possibility of other vectors other than the proposed Ixodes hexagonus.

Present status of PIK gadolinium control

International Nuclear Information System (INIS)

Petrov, Yu.V.; Garusov, E.A.; Shustov, V.A.

1994-01-01

A liquid control element (LCE) containing a water solution of gadolinium nitrate Gd(NO 3 ) 3 was originally planned for use at the PIK reactor for partial compensation of poisoning and fuel burnup [1-3]. However, a further analysis has shown that quick forcing-out, boiling up or flowing-out of the absorbing solution (though of low probability) can lead to the dangerous prompt overcriticality of the reactor. The results of the analysis are presented as well as the upper limit of the reactivity, quick insertion of which still is safe for the reactor (J.P.N.)

Between practice and theory: Melanie Klein, Anna Freud and the development of child analysis.

Science.gov (United States)

Donaldson, G

1996-04-01

An examination of the early history of child analysis in the writings of Melanie Klein and Anna Freud reveals how two different and opposing approaches to child analysis arose at the same time. The two methods of child analysis are rooted in a differential emphasis on psychoanalytic theory and practice. The Kleinian method derives from the application of technique while the Anna Freudian method is driven by theory. Furthermore, by holding to the Freudian theory of child development Anna Freud was forced to limit the scope of child analysis, while Klein's application of Freudian practice has led to new discoveries about the development of the infant psyche.

Partei tuhandete ja enda kommiraha eest 462 häält / Anna-Maria Galojan ; interv. Rainer Kerge

Index Scriptorium Estoniae

Galojan, Anna-Maria, 1982-

2007-01-01

Intervjuu parlamendivalimistel osalenud politoloogiamagistrant Anna-Maria Galojaniga tema osalemisest valimistel. Vt. samas: Kes on Anna-Maria Galojan? Küsimustele vastab Reformierakonna kampaaniajuht Arto Aas

Professor dr hab. Anna Maria Bujakiewicz

Directory of Open Access Journals (Sweden)

Anna Kujawa

2015-08-01

Full Text Available The article presents the biography and scientific achievements of Professor Anna Bujakiewicz. After receiving her master’s degree and doctorate in biology and mycology from Adam Mickiewicz University in Poznań, Professor Bujakiewicz continued her exciting research and teaching on mycology at her Alma Mater Posnaniensis for more than 50 years. Her publications in this field include many books, articles, and other scholarly reports.

Anna Louropoulou: 'Peri-implantitis vraagt om eenduidige behandelafspraken'

NARCIS (Netherlands)

Louropoulou, A.

2015-01-01

Het aantal geplaatste implantaten neemt toe, maar in de meeste gevallen ontbreekt een adequate nazorg. De NVvP nam het initiatief tot de ontwikkeling van een richtlijn perio-implantitis en zocht hiervoor de samenwerking met de NVOI. Parodontoloog/promovenda Anna Louropoulou: "De richtlijn is

Physiological Levels of Pik3ca H1047R Mutation in the Mouse Mammary Gland Results in Ductal Hyperplasia and Formation of ERα-Positive Tumors

Science.gov (United States)

Tikoo, Anjali; Roh, Vincent; Montgomery, Karen G.; Ivetac, Ivan; Waring, Paul; Pelzer, Rebecca; Hare, Lauren; Shackleton, Mark; Humbert, Patrick; Phillips, Wayne A.

2012-01-01

PIK3CA, the gene coding for the p110α subunit of phosphoinositide 3-kinase, is frequently mutated in a variety of human tumors including breast cancers. To better understand the role of mutant PIK3CA in the initiation and/or progression of breast cancer, we have generated mice with a conditional knock-in of the common activating mutation, Pik3caH1047R, into one allele of the endogenous gene in the mammary gland. These mice developed a ductal anaplasia and hyperplasia by 6 weeks of age characterized by multi-layering of the epithelial lining of the mammary ducts and expansion of the luminal progenitor (Lin−; CD29lo; CD24+; CD61+) cell population. The Pik3caH1047R expressing mice eventually develop mammary tumors with 100% penetrance but with a long latency (>12 months). This is significantly longer than has been reported for transgenic models where expression of the mutant Pik3ca is driven by an exogenous promoter. Histological analysis of the tumors formed revealed predominantly ERα-positive fibroadenomas, carcinosarcomas and sarcomas. In vitro induction of Pik3caH1047R in immortalized mammary epithelial cells also resulted in tumor formation when injected into the mammary fat pad of immunodeficient recipient mice. This novel model, which reproduces the scenario of a heterozygous somatic mutation occurring in the endogenous PIK3CA gene, will thus be a valuable tool for investigating the role of Pik3caH1047R mutation in mammary tumorigenesis both in vivo and in vitro. PMID:22666336

Physiological levels of Pik3ca(H1047R mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors.

Directory of Open Access Journals (Sweden)

Anjali Tikoo

Full Text Available PIK3CA, the gene coding for the p110α subunit of phosphoinositide 3-kinase, is frequently mutated in a variety of human tumors including breast cancers. To better understand the role of mutant PIK3CA in the initiation and/or progression of breast cancer, we have generated mice with a conditional knock-in of the common activating mutation, Pik3ca(H1047R, into one allele of the endogenous gene in the mammary gland. These mice developed a ductal anaplasia and hyperplasia by 6 weeks of age characterized by multi-layering of the epithelial lining of the mammary ducts and expansion of the luminal progenitor (Lin(-; CD29(lo; CD24(+; CD61(+ cell population. The Pik3ca(H1047R expressing mice eventually develop mammary tumors with 100% penetrance but with a long latency (>12 months. This is significantly longer than has been reported for transgenic models where expression of the mutant Pik3ca is driven by an exogenous promoter. Histological analysis of the tumors formed revealed predominantly ERα-positive fibroadenomas, carcinosarcomas and sarcomas. In vitro induction of Pik3ca(H1047R in immortalized mammary epithelial cells also resulted in tumor formation when injected into the mammary fat pad of immunodeficient recipient mice. This novel model, which reproduces the scenario of a heterozygous somatic mutation occurring in the endogenous PIK3CA gene, will thus be a valuable tool for investigating the role of Pik3ca(H1047R mutation in mammary tumorigenesis both in vivo and in vitro.

KRASness and PIK3CAness in patients with advanced colorectal cancer: outcome after treatment with early-phase trials with targeted pathway inhibitors.

Directory of Open Access Journals (Sweden)

Ignacio Garrido-Laguna

Full Text Available To evaluate clinicopathologic and molecular features of patients with metastatic colorectal cancer (mCRC and their outcomes in early-phase trials using pathway-targeting agents.We analyzed characteristics of 238 patients with mCRC referred to the phase 1 trials unit at MD Anderson Cancer Center. KRAS, PIK3CA and BRAF status were tested using PCR-based DNA sequencing.Fifty-one percent of patients harbored KRAS mutations; 15% had PIK3CA mutations. In the multivariate regression model for clinical characteristics KRAS mutations were associated with an increased incidence of lung and bone metastases and decreased incidence of adrenal metastases; PIK3CA mutations were marginally correlated with mucinous tumors (p = 0.05. In the univariate analysis, KRAS and PIK3CA mutations were strongly associated. Advanced Duke's stage (p<0.0001 and KRAS mutations (p = 0.01 were the only significant independent predictors of poor survival (Cox proportional hazards model. Patients with PIK3CA mutations had a trend toward shorter progression-free survival when treated with anti-EGFR therapies (p = 0.07. Eighteen of 78 assessable patients (23% treated with PI3K/Akt/mTOR axis inhibitors achieved stable disease [SD] ≥6 months or complete response/partial response (CR/PR, only one of whom were in the subgroup (N = 15 with PIK3CA mutations, perhaps because 10 of these 15 patients (67% had coexisting KRAS mutations. No SD ≥6 months/CR/PR was observed in the 10 patients treated with mitogen-activating protein kinase (MAPK pathway targeting drugs.KRAS and PIK3CA mutations frequently coexist in patients with colorectal cancer, and are associated with clinical characteristics and outcome. Overcoming resistance may require targeting both pathways.

Anna Dziemianko: User-friendliness of Verb Syntax in Pedagogical ...

African Journals Online (AJOL)

Abstract. Anna Dziemianko. User-friendliness of Verb Syntax in Pedagogical Dictionaries of English. 2006, XII + 229 pp. ISBN-13: 978-3-484-39130-7. ISBN- 10: 3-484-39130-8. Lexicographica. Series Maior 130. Tübingen: Max Niemeyer. Price: €124.

Astronaut Anna Fisher demonstrates sleep restraints on shuttle

Science.gov (United States)

1984-01-01

Astronaut Anna L. Fisher demonstrates the versatility of shuttle sleep restraints to accommodate the preference of crewmembers as she appears to have configured hers in a horizontal hammock mode. Stowage lockers, one of the middeck walls, another sleep restraint, a jury-rigged foot and hand restraint are among other items in the frame.

Genome Analysis of Latin American Cervical Cancer: Frequent Activation of the PIK3CA Pathway.

Science.gov (United States)

Lou, Hong; Villagran, Guillermo; Boland, Joseph F; Im, Kate M; Polo, Sarita; Zhou, Weiyin; Odey, Ushie; Juárez-Torres, Eligia; Medina-Martínez, Ingrid; Roman-Basaure, Edgar; Mitchell, Jason; Roberson, David; Sawitzke, Julie; Garland, Lisa; Rodríguez-Herrera, Maria; Wells, David; Troyer, Jennifer; Pinto, Francisco Castillo; Bass, Sara; Zhang, Xijun; Castillo, Miriam; Gold, Bert; Morales, Hesler; Yeager, Meredith; Berumen, Jaime; Alvirez, Enrique; Gharzouzi, Eduardo; Dean, Michael

2015-12-01

Cervical cancer is one of the most common causes of cancer mortality for women living in poverty, causing more than 28,000 deaths annually in Latin America and 266,000 worldwide. To better understand the molecular basis of the disease, we ascertained blood and tumor samples from Guatemala and Venezuela and performed genomic characterization. We performed human papillomavirus (HPV) typing and identified somatically mutated genes using exome and ultra-deep targeted sequencing with confirmation in samples from Mexico. Copy number changes were also assessed in the exome sequence. Cervical cancer cases in Guatemala and Venezuela have an average age of diagnosis of 50 years and 5.6 children. Analysis of 675 tumors revealed activation of PIK3CA and other PI3K/AKT pathway genes in 31% of squamous carcinomas and 24% of adeno- and adenosquamous tumors, predominantly at two sites (E542K, E545K) in the helical domain of the PIK3CA gene. This distribution of PIK3CA mutations is distinct from most other cancer types and does not result in the in vitro phosphorylation of AKT. Somatic mutations were more frequent in squamous carcinomas diagnosed after the age of 50 years. Frequent gain of chromosome 3q was found, and low PIK3CA mutation fractions in many tumors suggest that PI3K mutation can be a late event in tumor progression. PI3K pathway mutation is important to cervical carcinogenesis in Latin America. Therapeutic agents that directly target PI3K could play a role in the therapy of this common malignancy. ©2015 American Association for Cancer Research.

Interview with Dr Anna Matamala

Directory of Open Access Journals (Sweden)

Lucinea Marcelino Villela

2016-09-01

In this interview, which took place in June 2016, Dr Anna Matamala described some details about her long professional experience in Audiovisual Translation, especially in dubbing from English into Catalan, and we talked about many other things like her interest in lexicography, her point of view on some contemporary topics in Audiovisual Translation Studies: the use of technology, the relation between AVT and Accessibility Studies, AVT and Filmmaking fields, the importance of keeping in touch with other countries and even continents outside Europe, and she also gave some advice to the new generation of Translation students.

Interview with Dr Anna Matamala

Directory of Open Access Journals (Sweden)

Lucinea Marcelino Villela

2016-12-01

Full Text Available In this interview, which took place in June 2016, Dr Anna Matamala described some details about her long professional experience in Audiovisual Translation, especially in dubbing from English into Catalan, and we talked about many other things like her interest in lexicography, her point of view on some contemporary topics in Audiovisual Translation Studies: the use of technology, the relation between AVT and Accessibility Studies, AVT and Filmmaking fields, the importance of keeping in touch with other countries and even continents outside Europe, and she also gave some advice to the new generation of Translation students.

Evaluation of Proctophyllodes huitzilopochtlii on feathers from Anna's (Calypte anna) and Black-chinned (Archilochus alexandri) Hummingbirds: Prevalence assessment and imaging analysis using light and tabletop scanning electron microscopy.

Science.gov (United States)

Yamasaki, Youki K; Graves, Emily E; Houston, Robin S; OConnor, Barry M; Kysar, Patricia E; Straub, Mary H; Foley, Janet E; Tell, Lisa A

2018-01-01

Proctophyllodes huitzilopochtlii Atyeo & Braasch 1966 (Acariformes: Astigmata: Proctophyllodidae), a feather mite, was found on feathers collected from five hummingbird species in California. This mite has not been previously documented on feathers from Anna's (Calypte anna [Lesson 1829]) or Black-chinned (Archilochus alexandri [Bourcier & Mulsant 1846]) Hummingbirds. A total of 753 hummingbirds were evaluated for the presence of mites by species (Allen's n = 112; Anna's n = 500; Black-chinned n = 122; Rufous n = 18; Calliope n = 1), sex (males n = 421; females n = 329; 3 unidentified), and age (juvenile n = 199; after-hatch-year n = 549; 5 unidentified). Of these 753 hummingbirds evaluated, mites were present on the rectrices of 40.9% of the birds. Significantly more Anna's Hummingbirds were positive for rectricial mites (59.2%) compared with 8.2% of Black-chinned, 0.9% of Allen's, 5.6% of Rufous Hummingbirds, and 0% for Calliope (p-value hummingbird species, male hummingbirds (44.9%) had a higher prevalence of rectricial mites compared to female hummingbirds (36.2%; p-value = 0.004), while juvenile hummingbirds (46.2%) had a non-significantly higher prevalence compared to after-hatch-year hummingbirds (39.0%; p-value = 0.089). On average, the percentage of the long axis of the rachis occupied by mites for the outer rectrices (R4 and R5) was 19%, compared to 11% for inner rectrices (R1 and R2), a significant difference (p-value = hummingbird-feather mite relationship is not well understood, but the specialized TSEM technique may be especially useful in examining natural positioning and developmental aspects of the mites since it allows in situ feather examination of live mites.

Anna Politkovskaja mälestus Euroopas / Marianne Mikko

Index Scriptorium Estoniae

Mikko, Marianne, 1961-

2007-01-01

Ilmunud ka: Virumaa Teataja, 18. sept. 2007, lk. 11; Põhjarannik, 18. sept. 2007, lk. 4; Severnoje Poberezhje, 18. sept. 2007, lk. 4; Sakala, 21. sept. 2007, lk. 2. Euroopa Parlamendi saadik toetas ideed anda Euroopa Parlamendi pressiruumile Anna Politkovskaja nimi, sellega antakse Venemaale ka teada, mida europarlament arvab Vene võimude tegevusest Tšetšeenias

Characterization of solid radwaste generated at Virginia Power's Surry and North Anna stations

International Nuclear Information System (INIS)

Lippard, D.W.; Elguindy, H.; Nelson, R.A.

1987-01-01

This paper describes the results of a study on characterization of the major constituents of the solid radwaste generated at Virginia Power's North Anna and Surry Power Stations. The characterization consisted of identifying the individual constituents of the dry active waste (DAW) and estimating the fraction of the total DAW (both weight and volume) made up by each constituent. The analysis of the characterization of solid waste streams generated at both North Anna and Surry stations has lead to recommending techniques for both source minimization and waste volume reduction

Infantile sexuality: Its place in the conceptual developments of Anna Freud and Donald W. Winnicott.

Science.gov (United States)

Joyce, Angela

2016-06-01

This essay explores the place of infantile sexuality in the theories of Anna Freud and Donald W Winnicott. Both Anna Freud and D.W. Winnicott incorporated and at the same time changed the classical psychoanalytic account of infantile sexuality and the instinctual drives. Whilst Anna Freud remained closer to her father's original conceptualization, she developed a multidimensional model of development which gave the drives a foundational status whist also maintaining their significance in giving meaning and texture to children's subjective experience. Winnicott also retained much of S. Freud's original theorizing except that in a fundamental way he turned it on its head when considering earliest development. For him the establishment of the self was paramount, and the drives and infantile sexuality merely served to give substance to that self. Copyright © 2016 Institute of Psychoanalysis.

Kõrkjasaar Põlvas = Bulrush Island in Põlva / Anna-Liisa Unt

Index Scriptorium Estoniae

Unt, Anna-Liisa, 1982-

2004-01-01

Põlvas 2003. a. korraldatud ideevõistluste tulemused: keskpargi võistlus: II preemia - OÜ Kaunimad Aiad, III - Mart Mets; paisjärve kujunduse konkurss: II - Anna-Liisa Unt, III - Mart Mets. A.-L. Undi realiseeritud võistlustööst, paisjärve saare valguskujundusest. 4 ill

Dual HER2\\PIK3CA targeting overcomes single-agent acquired resistance in HER2 amplified uterine serous carcinoma cell lines in vitro and in vivo

Science.gov (United States)

Lopez, Salvatore; Cocco, Emiliano; Black, Jonathan; Bellone, Stefania; Bonazzoli, Elena; Predolini, Federica; Ferrari, Francesca; Schwab, Carlton L.; English, Diana P.; Ratner, Elena; Silasi, Dan-Arin; Azodi, Masoud; Schwartz, Peter E.; Terranova, Corrado; Angioli, Roberto; Santin, Alessandro D.

2015-01-01

HER2/neu gene amplification and PIK3CA driver mutations are common in uterine serous carcinoma (USC), and may represent ideal therapeutic targets against this aggressive variant of endometrial cancer. We examined the sensitivity to neratinib, taselisib and the combination of the two compounds in in vitro and in vivo experiments using PIK3CA mutated and PIK3CA-wild type HER2/neu amplified USC cell lines. Cell viability and cell cycle distribution were assessed using flow-cytometry assays. Downstream signaling was assessed by immunoblotting. Preclinical efficacy of single versus dual inhibition was evaluated in vivo using two USC-xenografts. We found both single agent neratinib and taselisib to be active but only transiently effective in controlling the in vivo growth of USC xenografts harboring HER2/neu gene amplification with or without oncogenic PIK3CA mutations. In contrast, the combination of the two inhibitors caused a stronger and long lasting growth inhibition in both USC xenografts when compared to single agent therapy. Combined targeting of HER2 and PIK3CA was associated with a significant and dose-dependent increase in the percentage of cells in the G0/G1 phase of the cell cycle and a dose-dependent decline in the phosphorylation of S6. Importantly, dual inhibition therapy initiated after tumor progression in single agent-treated mice was still remarkably effective at inducing tumor regression in both large PIK3CA or pan-ErbB inhibitor-resistant USC xenografts. Dual HER2/PIK3CA blockade may represent a novel therapeutic option for USC patients harboring tumors with HER2/neu gene amplification and mutated or wild type PIK3CA resistant to chemotherapy. PMID:26333383

Dual HER2/PIK3CA Targeting Overcomes Single-Agent Acquired Resistance in HER2-Amplified Uterine Serous Carcinoma Cell Lines In Vitro and In Vivo.

Science.gov (United States)

Lopez, Salvatore; Cocco, Emiliano; Black, Jonathan; Bellone, Stefania; Bonazzoli, Elena; Predolini, Federica; Ferrari, Francesca; Schwab, Carlton L; English, Diana P; Ratner, Elena; Silasi, Dan-Arin; Azodi, Masoud; Schwartz, Peter E; Terranova, Corrado; Angioli, Roberto; Santin, Alessandro D

2015-11-01

HER2/neu gene amplification and PIK3CA driver mutations are common in uterine serous carcinoma (USC) and may represent ideal therapeutic targets against this aggressive variant of endometrial cancer. We examined the sensitivity to neratinib, taselisib, and the combination of the two compounds in in vitro and in vivo experiments using PIK3CA-mutated and PIK3CA wild-type HER2/neu-amplified USC cell lines. Cell viability and cell-cycle distribution were assessed using flow-cytometry assays. Downstream signaling was assessed by immunoblotting. Preclinical efficacy of single versus dual inhibition was evaluated in vivo using two USC xenografts. We found both single-agent neratinib and taselisib to be active but only transiently effective in controlling the in vivo growth of USC xenografts harboring HER2/neu gene amplification with or without oncogenic PIK3CA mutations. In contrast, the combination of the two inhibitors caused a stronger and long-lasting growth inhibition in both USC xenografts when compared with single-agent therapy. Combined targeting of HER2 and PIK3CA was associated with a significant and dose-dependent increase in the percentage of cells in the G0-G1 phase of the cell cycle and a dose-dependent decline in the phosphorylation of S6. Importantly, dual inhibition therapy initiated after tumor progression in single-agent-treated mice was still remarkably effective at inducing tumor regression in both large PIK3CA and pan-ErbB inhibitor-resistant USC xenografts. Dual HER2/PIK3CA blockade may represent a novel therapeutic option for USC patients harboring tumors with HER2/neu gene amplification and mutated or wild-type PIK3CA resistant to chemotherapy. ©2015 American Association for Cancer Research.

Oligonucleotide PIK3CA/Chromosome 3 Dual in Situ Hybridization Automated Assay with Improved Signals, One-Hour Hybridization, and No Use of Blocking DNA.

Science.gov (United States)

Zhang, Wenjun; Hubbard, Antony; Baca-Parkinson, Leslie; Stanislaw, Stacey; Vladich, Frank; Robida, Mark D; Grille, James G; Maxwell, Daniel; Tsao, Tsu-Shuen; Carroll, William; Gardner, Tracie; Clements, June; Singh, Shalini; Tang, Lei

2015-09-01

The PIK3CA gene at chromosome 3q26.32 was found to be amplified in up to 45% of patients with squamous cell carcinoma of the lung. The strong correlation between PIK3CA amplification and increased phosphatidylinositol 3-kinase (PI3K) pathway activities suggested that PIK3CA gene copy number is a potential predictive biomarker for PI3K inhibitors. Currently, all microscopic assessments of PIK3CA and chromosome 3 (CHR3) copy numbers use fluorescence in situ hybridization. PIK3CA probes are derived from bacterial artificial chromosomes whereas CHR3 probes are derived mainly from the plasmid pHS05. These manual fluorescence in situ hybridization assays mandate 12- to 18-hour hybridization and use of blocking DNA from human sources. Moreover, fluorescence in situ hybridization studies provide limited morphologic assessment and suffer from signal decay. We developed an oligonucleotide-based bright-field in situ hybridization assay that overcomes these shortcomings. This assay requires only a 1-hour hybridization with no need for blocking DNA followed by indirect chromogenic detection. Oligonucleotide probes produced discrete and uniform CHR3 stains superior to those from the pHS05 plasmid. This assay achieved successful staining in 100% of the 195 lung squamous cell carcinoma resections and in 94% of the 33 fine-needle aspirates. This robust automated bright-field dual in situ hybridization assay for the simultaneous detection of PIK3CA and CHR3 centromere provides a potential clinical diagnostic method to assess PIK3CA gene abnormality in lung tumors. Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas.

Science.gov (United States)

Yamaguchi, Hiroshi; Kuboki, Yuko; Hatori, Takashi; Yamamoto, Masakazu; Shiratori, Keiko; Kawamura, Shunji; Kobayashi, Makio; Shimizu, Michio; Ban, Shinichi; Koyama, Isamu; Higashi, Morihiro; Shin, Nobuhiro; Ishida, Kazuyuki; Morikawa, Takanori; Motoi, Fuyuhiko; Unno, Michiaki; Kanno, Atsushi; Satoh, Kennichi; Shimosegawa, Tooru; Orikasa, Hideki; Watanabe, Tomoo; Nishimura, Kazuhiko; Harada, Youji; Furukawa, Toru

2011-12-01

Intraductal tubulopapillary neoplasm (ITPN) is a recently recognized rare variant of intraductal neoplasms of the pancreas. Molecular aberrations underlying the neoplasm remain unknown. We investigated somatic mutations in PIK3CA, PTEN, AKT1, KRAS, and BRAF. We also investigated aberrant expressions of phosphorylated AKT, phosphatase and tensin homolog (PTEN), tumor protein 53 (TP53), SMAD4, and CTNNB1 in 11 cases of ITPNs and compared these data with those of 50 cases of intraductal papillary mucinous neoplasm (IPMN), another distinct variant of pancreatic intraductal neoplasms. Mutations in PIK3CA were found in 3 of 11 ITPNs but not in IPMNs (P = 0.005; Fisher exact test). In contrast, mutations in KRAS were found in none of the ITPNs but were found in 26 of the 50 IPMNs (P = 0.001; Fisher exact test). PIK3CA mutations were associated with strong expression of phosphorylated AKT (P AKT was apparent in most ITPNs but only in a few IPMNs (P SMAD4, and CTNNB1 were not statistically different between these neoplasms. Mutations in PIK3CA and the expression of phosphorylated AKT were not associated with age, sex, tissue invasion, and patients' prognosis in ITPNs. These results indicate that activation of the phosphatidylinositol 3-kinase pathway may play a crucial role in ITPNs but not in IPMNs. In contrast, the mutation in KRAS seems to play a major role in IPMNs but not in ITPNs. The activated phosphatidylinositol 3-kinase pathway may be a potential target for molecular diagnosis and therapy of ITPNs.

Anna Freud: the Hampstead War Nurseries and the role of the direct observation of children for psychoanalysis.

Science.gov (United States)

Midgley, Nick

2007-08-01

The psychoanalytic tradition of direct observation of children has a long history, going back to the early 20th century, when psychoanalysis and the emerging field of 'child studies' came into fruitful contact in Freud's Vienna. As a leading figure in the attempted integration of direct observation with the new psychoanalytic knowledge emerging from the consulting room, Anna Freud played a crucial role in the emergence of this field. But her major contribution to the theory and practice of observing children came during the Second World War, when she founded the Hampstead War Nurseries. The author describes in detail this important period of Anna Freud's career, and discusses the impact it had on later work. He explores the theoretical contribution that Anna Freud made in the post-war years to the debate about the place of direct observation in psychoanalysis, and concludes that Anna Freud's 'double approach' (direct observation plus analytic reconstruction) still has a great deal to offer as a method of both psychoanalytic research and education.

UCN sources at external beams of thermal neutrons. An example of PIK reactor

International Nuclear Information System (INIS)

Lychagin, E.V.; Mityukhlyaev, V.A.; Muzychka, A.Yu.; Nekhaev, G.V.; Nesvizhevsky, V.V.; Onegin, M.S.; Sharapov, E.I.; Strelkov, A.V.

2016-01-01

We consider ultracold neutron (UCN) sources based on a new method of UCN production in superfluid helium ("4He). The PIK reactor is chosen as a perspective example of application of this idea, which consists of installing "4He UCN source in the beam of thermal or cold neutrons and surrounding the source with moderator-reflector, which plays the role of cold neutron (CN) source feeding the UCN source. CN flux in the source can be several times larger than the incident flux, due to multiple neutron reflections from the moderator–reflector. We show that such a source at the PIK reactor would provide an order of magnitude larger density and production rate than an analogous source at the ILL reactor. We estimate parameters of "4He source with solid methane (CH_4) or/and liquid deuterium (D_2) moderator–reflector. We show that such a source with CH_4 moderator–reflector at the PIK reactor would provide the UCN density of ~1·10"5 cm"−"3, and the UCN production rate of ~2·10"7 s"−"1. These values are respectively 1000 and 20 times larger than those for the most intense UCN user source. The UCN density in a source with D_2 moderator-reflector would reach the value of ~2·10"5 cm"−"3, and the UCN production rate would be equal ~8·10"7 s"−"1. Installation of such a source in a beam of CNs would slightly increase the density and production rate.

Melanie Klein and Anna Freud: the discourse of the early dispute.

Science.gov (United States)

Viner, R

1996-01-01

Divisions in the field of the psychoanalysis of children can be traced to a dispute over the infantile super-ego between the theorists Melanie Klein and Anna Freud beginning in 1927. These divisions are understood within the analytic world as the result of scientific disputation between alternative valid theories. An examination of the language, claims, and epistemology of Klein's and Freud's publications in 1927 that marked the public commencement of the conflict, reveals a personalized discourse in which authority was derived from the allegiance, experience, and personal analytic standing of the contestants as much as from theoretical insight. The structure and rhetoric of the debate suggest that, rather than terminating the dispute, the publications of 1927 served to encourage professionalization in child analysis and establish Anna Freud and Melanie Klein as authoritative alternative theorists.

Peter Heller's a Child Analysis with Anna Freud: the significance of the case for the history of child psychoanalysis.

Science.gov (United States)

Midgley, Nick

2012-02-01

A Child Analysis with Anna Freud, a collection of Anna Freud's detailed case notes of her treatment of the young Peter Heller between 1929 and 1932, was first published in English in 1990. Not only does this work give us direct access to Anna Freud's ways of thinking and working at a crucial period in the early history of child analysis; it is also one of the few records of an adult reflecting in depth on the experience of being in analysis as a child. Yet to date this work has received little attention in the psychoanalytic literature. In an attempt to redress this neglect, the Heller case study is placed in the context of Anna Freud's emerging ideas about child analysis. In particular, its significance in the development of her psychoanalytic thinking is investigated in the light of her 1927 book, The Technique of Child Analysis.

BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: Primary or secondary genetic events in colorectal carcinogenesis?

Directory of Open Access Journals (Sweden)

Schmitt Fernando

2008-09-01

Full Text Available Abstract Background BRAF, KRAS and PIK3CA mutations are frequently found in sporadic colorectal cancer (CRC. In contrast to KRAS and PIK3CA mutations, BRAF mutations are associated with tumours harbouring CpG Island methylation phenotype (CIMP, MLH1 methylation and microsatellite instability (MSI. We aimed at determine the frequency of KRAS, BRAF and PIK3CA mutations in the process of colorectal tumourigenesis using a series of colorectal polyps and carcinomas. In the series of polyps CIMP, MLH1 methylation and MSI were also studied. Methods Mutation analyses were performed by PCR/sequencing. Bisulfite treated DNA was used to study CIMP and MLH1 methylation. MSI was detected by pentaplex PCR and Genescan analysis of quasimonomorphic mononucleotide repeats. Chi Square test and Fisher's Exact test were used to perform association studies. Results KRAS, PIK3CA or BRAF occur in 71% of polyps and were mutually exclusive. KRAS mutations occur in 35% of polyps. PIK3CA was found in one of the polyps. V600E BRAF mutations occur in 29% of cases, all of them classified as serrated adenoma. CIMP phenotype occurred in 25% of the polyps and all were mutated for BRAF. MLH1 methylation was not detected and all the polyps were microsatellite stable. The comparison between the frequency of oncogenic mutations in polyps and CRC (MSI and MSS lead us to demonstrate that KRAS and PIK3CA are likely to precede both types of CRC. BRAF mutations are likely to precede MSI carcinomas since the frequency found in serrated polyps is similar to what is found in MSI CRC (P = 0.9112, but statistically different from what is found in microsatellite stable (MSS tumours (P = 0.0191. Conclusion Our results show that BRAF, KRAS and PIK3CA mutations occur prior to malignant transformation demonstrating that these oncogenic alterations are primary genetic events in colorectal carcinogenesis. Further, we show that BRAF mutations occur in association with CIMP phenotype in colorectal

BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: Primary or secondary genetic events in colorectal carcinogenesis?

International Nuclear Information System (INIS)

Velho, Sérgia; Moutinho, Cátia; Cirnes, Luís; Albuquerque, Cristina; Hamelin, Richard; Schmitt, Fernando; Carneiro, Fátima; Oliveira, Carla; Seruca, Raquel

2008-01-01

BRAF, KRAS and PIK3CA mutations are frequently found in sporadic colorectal cancer (CRC). In contrast to KRAS and PIK3CA mutations, BRAF mutations are associated with tumours harbouring CpG Island methylation phenotype (CIMP), MLH1 methylation and microsatellite instability (MSI). We aimed at determine the frequency of KRAS, BRAF and PIK3CA mutations in the process of colorectal tumourigenesis using a series of colorectal polyps and carcinomas. In the series of polyps CIMP, MLH1 methylation and MSI were also studied. Mutation analyses were performed by PCR/sequencing. Bisulfite treated DNA was used to study CIMP and MLH1 methylation. MSI was detected by pentaplex PCR and Genescan analysis of quasimonomorphic mononucleotide repeats. Chi Square test and Fisher's Exact test were used to perform association studies. KRAS, PIK3CA or BRAF occur in 71% of polyps and were mutually exclusive. KRAS mutations occur in 35% of polyps. PIK3CA was found in one of the polyps. V600E BRAF mutations occur in 29% of cases, all of them classified as serrated adenoma. CIMP phenotype occurred in 25% of the polyps and all were mutated for BRAF. MLH1 methylation was not detected and all the polyps were microsatellite stable. The comparison between the frequency of oncogenic mutations in polyps and CRC (MSI and MSS) lead us to demonstrate that KRAS and PIK3CA are likely to precede both types of CRC. BRAF mutations are likely to precede MSI carcinomas since the frequency found in serrated polyps is similar to what is found in MSI CRC (P = 0.9112), but statistically different from what is found in microsatellite stable (MSS) tumours (P = 0.0191). Our results show that BRAF, KRAS and PIK3CA mutations occur prior to malignant transformation demonstrating that these oncogenic alterations are primary genetic events in colorectal carcinogenesis. Further, we show that BRAF mutations occur in association with CIMP phenotype in colorectal serrated polyps and verified that colorectal serrated

Intertekstualiteit en die Bose in Kroniek van Perdepoort (Anna M. Louw

Directory of Open Access Journals (Sweden)

E. Linde

1986-05-01

Patrick White is also an author of religious literature to whom Anna M. Louw is attracted by her own admission. His novels. The solid Mandala and Riders in the Chariot are studied, and similarities with Kroniek van Perdepoort indicated.

SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells.

Science.gov (United States)

Pasquier, Benoit

2015-04-03

Autophagy plays an important role in cancer and it has been suggested that it functions not only as a tumor suppressor pathway to prevent tumor initiation, but also as a prosurvival pathway that helps tumor cells endure metabolic stress and resist death triggered by chemotherapeutic agents. We recently described the discovery of inhibitors of PIK3C3/Vps34 (phosphatidylinositol 3-kinase, catalytic subunit type 3), the lipid kinase component of the class III phosphatidylinositol 3-kinase (PtdIns3K). This PtdIns3K isoform has attracted significant attention in recent years because of its role in autophagy. Following chemical optimization we identified SAR405, a low molecular mass kinase inhibitor of PIK3C3, highly potent and selective with regard to other lipid and protein kinases. We demonstrated that inhibiting the catalytic activity of PIK3C3 disrupts vesicle trafficking from late endosomes to lysosomes. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. Finally our results show that combining SAR405 with everolimus, the FDA-approved MTOR inhibitor, results in a significant synergy on the reduction of cell proliferation using renal tumor cells. This result indicates a potential therapeutic application for PIK3C3 inhibitors in cancer.

Astronaut Anna Fisher practices control of the RMS in a trainer

Science.gov (United States)

1984-01-01

Astronaut Anna Lee Fisher, mission specialist for 51-A, practices control of the remote manipulator system (RMS) at a special trainer at JSC. Dr. Fisher is pictured in the manipulator development facility (MDF) of JSC's Shuttle mockup and integration laboratory.

Anna Groundwater, The Scottish Middle March 1573-1625: Power, Kinship, Allegiance

Directory of Open Access Journals (Sweden)

Janine van Vliet

2011-09-01

Full Text Available Anna Groundwater. The Scottish Middle March 1573-1625: Power, Kinship, Allegiance. Royal Historical Society Studies in History, New Series. Woodbridge, UK: The Boydell Press, 2010. Pp. 236. ISBN 978-0-86193-307-5. £50.00; US$90.00.

Wingbeat kinematics and motor control of yaw turns in Anna's hummingbirds (Calypte anna).

Science.gov (United States)

Altshuler, Douglas L; Quicazán-Rubio, Elsa M; Segre, Paolo S; Middleton, Kevin M

2012-12-01

The biomechanical and neuromuscular mechanisms used by different animals to generate turns in flight are highly variable. Body size and body plan exert some influence, e.g. birds typically roll their body to orient forces generated by the wings whereas insects are capable of turning via left-right wingbeat asymmetries. Turns are also relatively brief and have low repeatability, with almost every wingbeat serving a different function throughout the change in heading. Here we present an analysis of Anna's hummingbirds (Calypte anna) as they fed continuously from an artificial feeder revolving around the outside of the animal. This setup allowed for examination of sustained changes in yaw without requiring any corresponding changes in pitch, roll or body position. Hummingbirds sustained yaw turns by expanding the wing stroke amplitude of the outer wing during the downstroke and by altering the deviation of the wingtip path during both downstroke and upstroke. The latter led to a shift in the inner-outer stroke plane angle during the upstroke and shifts in the elevation of the stroke plane and in the deviation of the wingtip path during both strokes. These features are generally more similar to how insects, as opposed to birds, turn. However, time series analysis also revealed considerable stroke-to-stroke variation. Changes in the stroke amplitude and the wingtip velocity were highly cross-correlated, as were changes in the stroke deviation and the elevation of the stroke plane. As was the case for wingbeat kinematics, electromyogram recordings from pectoral and wing muscles were highly variable, but no correlations were found between these two features of motor control. The high variability of both kinematic and muscle activation features indicates a high level of wingbeat-to-wingbeat adjustments during sustained yaw. The activation timing of the muscles was more repeatable than the activation intensity, which suggests that the former may be constrained by harmonic

Kundnöjdheten i Hotel Anna

OpenAIRE

Boije, Daniel

2014-01-01

I dagens läge värderas kundrelationer högt inom marknadsföringen. Kundnöjdhet förknippas med lönsamhet och ses som en långsiktig investering. Hotel Anna är ett litet hotell i centrala Helsingfors och fungerar som min uppdragsgivare. Syftet med detta arbete är att utreda kundnöjdheten samt hur kundbetjäning och kvalitet upplevs i hotellet. Delsyftet är också att hitta kundnöjdhets förbättringsförslag för hotellet. Den teoretiska referensramen består av teori som behandlar tjänster, kvalitet, k...

Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors

International Nuclear Information System (INIS)

Naguib, Adam; Arends, Mark J; Cooke, James C; Happerfield, Lisa; Kerr, Lucy; Gay, Laura J; Luben, Robert N; Ball, Richard Y; Mitrou, Panagiota N; McTaggart, Alison

2011-01-01

The PTEN tumour suppressor gene and PIK3CA proto-oncogene encode proteins which contribute to regulation and propagation of signal transduction through the PI3K/AKT signalling pathway. This study investigates the prevalence of loss of PTEN expression and mutations in both PTEN and PIK3CA in colorectal cancers (CRC) and their associations with tumour clinicopathological features, lifestyle factors and dietary consumptions. 186 adenocarcinomas and 16 adenomas from the EPIC Norfolk study were tested for PTEN and PIK3CA mutations by DNA sequencing and PTEN expression changes by immunohistochemistry. Dietary and lifestyle data were collected prospectively using seven day food diaries and lifestyle questionnaires. Mutations in exons 7 and 8 of PTEN were observed in 2.2% of CRC and PTEN loss of expression was identified in 34.9% CRC. Negative PTEN expression was associated with lower blood low-density lipoprotein concentrations (p = 0.05). PIK3CA mutations were observed in 7% of cancers and were more frequent in CRCs in females (p = 0.04). Analysis of dietary intakes demonstrated no link between PTEN expression status and any specific dietary factor. PTEN expression negative, proximal CRC were of more advanced Dukes' stage (p = 0.02) and poor differentiation (p < 0.01). Testing of the prevalence of PIK3CA mutations and loss of PTEN expression demonstrated that these two events were independent (p = 0.55). These data demonstrated the frequent occurrence (34.9%) of PTEN loss of expression in colorectal cancers, for which gene mutations do not appear to be the main cause. Furthermore, dietary factors are not associated with loss of PTEN expression. PTEN expression negative CRC were not homogenous, as proximal cancers were associated with a more advanced Dukes' stage and poor differentiation, whereas distal cancers were associated with earlier Dukes' stage

Relative quantification of PIK3CA gene expression level in fine-needle aspiration biopsy thyroid specimens collected from patients with papillary thyroid carcinoma and non-toxic goitre by real-time RT-PCR

Directory of Open Access Journals (Sweden)

Wojciechowska-Durczyńska Katarzyna

2010-08-01

Full Text Available Abstract Background Recent studies have shown that the phosphatidylinositol 3-kinase (PI3K signaling pathway is important regulator of many cellular events, including apoptosis, proliferation and motility. PI3K pathway alterations (PIK3CA gene mutations and/or amplification have been observed in various human tumours. In the majority of diagnosed cases, mutations are localized in one of the three "hot spots" in the gene, responsible for coding catalytic subunit α of class I PI3K (PIK3CA. Mutations and amplification of PIK3CA gene are characteristic for thyroid cancer, as well. Methods The aim of our study was to examine a gene expression level of PIK3CA in fine-needle aspiration biopsy (FNAB thyroid specimens in two types of thyroid lesions, papillary thyroid carcinoma (PTC and non-toxic goitre (NTG. Following conventional cytological examination, 42 thyroid FNAB specimens, received from patients with PTC (n = 20 and NTG (n = 22, were quantitatively evaluated regarding PIK3CA expression level by real-time PCR in the ABI PRISM® 7500 Sequence Detection System. Results Significantly higher expression level (RQ of PIK3CA in PTC group has been noted in comparison with NTG group (p Conclusion These observations may suggest role of PIK3CA alterations in PTC carcinogenesis.

Detection of Babesia annae DNA in lung exudate samples from Red foxes (Vulpes vulpes) in Great Britain.

Science.gov (United States)

Bartley, Paul M; Hamilton, Clare; Wilson, Cari; Innes, Elisabeth A; Katzer, Frank

2016-02-12

This study aimed to determine the prevalence of Babesia species DNA in lung exudate samples collected from red foxes (Vulpes vulpes) from across Great Britain. Babesia are small piroplasmid parasites which are mainly transmitted through the bite of infected ticks of the family Ixodidae. Babesia can cause potentially fatal disease in a wide-range of mammalian species including humans, dogs and cattle, making them of significant economic importance to both the medical and veterinary fields. DNA was extracted from lung exudate samples of 316 foxes. A semi-nested PCR was used to initially screen samples, using universal Babesia-Theileria primers which target the 18S rRNA gene. A selection of positive PCR amplicons were purified and sequenced. Subsequently specific primers were designed to detect Babesia annae and used to screen all 316 DNA samples. Randomly selected positive samples were purified and sequenced (GenBank accession KT580786). Clones spanning a 1717 bp region of the 18S rRNA gene were generated from 2 positive samples, the resultant consensus sequence was submitted to GenBank (KT580785). Sequence KT580785 was used in the phylogenetic analysis Babesia annae DNA was detected in the fox samples, in total 46/316 (14.6%) of samples tested positive for the presence of Babesia annae DNA. The central region of England had the highest prevalence at 36.7%, while no positive samples were found from Wales, though only 12 samples were tested from this region. Male foxes were found to have a higher prevalence of Babesia annae DNA than females in all regions of Britain. Phylogenetic and sequence analysis of the GenBank submissions (Accession numbers KT580785 and KT580786) showed 100% identity to Babesia sp.-'Spanish Dog' (AY534602, EU583387 and AF188001). This is the first time that Babesia annae DNA has been reported in red foxes in Great Britain with positive samples being found across England and Scotland indicating that this parasite is well established within the

[Participation of the Anna Nery School in the Constitutionalist Revolution of 1932].

Science.gov (United States)

de Almeida Filho, Antonio José; Santos, Tânia Cristina Franco

2003-01-01

This is a historical-social research project. The main objective is to present the participation of the Anna Nery Nursing School in the medical assistance positions in the state of Sao Paulo during the Constitutionalist Revolution of 1932. The objective of the present investigation is to describe how the teachers and students of the Anna Nery Nursing School participated in the different operation fronts during this war and to analyse the implications of the performance of nurses and students of this School. Our main documental resource were written and photographical documents that belong to the Centre of Documentation of the EEA/UFRJ. The secondary source were articles and books that about the history of Brazil and Brazilian nursing. This investigation evidenced the importance of the nurse's work during times of crisis and it also made possible for the EEAN to earn symbolic profits.

Characterisation of mutations of the phosphoinositide-3-kinase regulatory subunit, PIK3R2, in perisylvian polymicrogyria: a next-generation sequencing study.

Science.gov (United States)

Mirzaa, Ghayda M; Conti, Valerio; Timms, Andrew E; Smyser, Christopher D; Ahmed, Sarah; Carter, Melissa; Barnett, Sarah; Hufnagel, Robert B; Goldstein, Amy; Narumi-Kishimoto, Yoko; Olds, Carissa; Collins, Sarah; Johnston, Kathreen; Deleuze, Jean-François; Nitschké, Patrick; Friend, Kathryn; Harris, Catharine; Goetsch, Allison; Martin, Beth; Boyle, Evan August; Parrini, Elena; Mei, Davide; Tattini, Lorenzo; Slavotinek, Anne; Blair, Ed; Barnett, Christopher; Shendure, Jay; Chelly, Jamel; Dobyns, William B; Guerrini, Renzo

2015-12-01

Bilateral perisylvian polymicrogyria (BPP), the most common form of regional polymicrogyria, causes the congenital bilateral perisylvian syndrome, featuring oromotor dysfunction, cognitive impairment, and epilepsy. The causes of BPP are heterogeneous, but only a few genetic causes have been reported. The aim of this study was to identify additional genetic causes of BPP and characterise their frequency in this population. Children (aged ≤18 years) with polymicrogyria were enrolled into our research programme from July, 1980, to October, 2015, at two centres (Florence, Italy, and Seattle, WA, USA). We obtained samples (blood and saliva) throughout this period at both centres and did whole-exome sequencing on DNA from eight trios (two parents and one affected child) with BPP in 2014. After the identification of mosaic PIK3R2 mutations in two of these eight children, we performed targeted screening of PIK3R2 by two methods in a cohort of 118 children with BPP. First, we performed targeted sequencing of the entire PIK3R2 gene by single molecule molecular inversion probes (smMIPs) on 38 patients with BPP with normal to large head size. Second, we did amplicon sequencing of the recurrent PIK3R2 mutation (Gly373Arg) in 80 children with various types of polymicrogyria including BPP. One additional patient had clinical whole-exome sequencing done independently, and was included in this study because of the phenotypic similarity to our cohort. We identified a mosaic mutation (Gly373Arg) in a regulatory subunit of the PI3K-AKT-mTOR pathway, PIK3R2, in two children with BPP. Of the 38 patients with BPP and normal to large head size who underwent targeted next-generation sequencing by smMIPs, we identified constitutional and mosaic PIK3R2 mutations in 17 additional children. In parallel, one patient had the recurrent PIK3R2 mutation identified by clinical whole-exome sequencing. Seven of these 20 patients had BPP alone, and 13 had BPP in association with features of the

Evaluation of Proctophyllodes huitzilopochtlii on feathers from Anna's (Calypte anna and Black-chinned (Archilochus alexandri Hummingbirds: Prevalence assessment and imaging analysis using light and tabletop scanning electron microscopy.

Directory of Open Access Journals (Sweden)

Youki K Yamasaki

Full Text Available Proctophyllodes huitzilopochtlii Atyeo & Braasch 1966 (Acariformes: Astigmata: Proctophyllodidae, a feather mite, was found on feathers collected from five hummingbird species in California. This mite has not been previously documented on feathers from Anna's (Calypte anna [Lesson 1829] or Black-chinned (Archilochus alexandri [Bourcier & Mulsant 1846] Hummingbirds. A total of 753 hummingbirds were evaluated for the presence of mites by species (Allen's n = 112; Anna's n = 500; Black-chinned n = 122; Rufous n = 18; Calliope n = 1, sex (males n = 421; females n = 329; 3 unidentified, and age (juvenile n = 199; after-hatch-year n = 549; 5 unidentified. Of these 753 hummingbirds evaluated, mites were present on the rectrices of 40.9% of the birds. Significantly more Anna's Hummingbirds were positive for rectricial mites (59.2% compared with 8.2% of Black-chinned, 0.9% of Allen's, 5.6% of Rufous Hummingbirds, and 0% for Calliope (p-value < 0.0001. Across all hummingbird species, male hummingbirds (44.9% had a higher prevalence of rectricial mites compared to female hummingbirds (36.2%; p-value = 0.004, while juvenile hummingbirds (46.2% had a non-significantly higher prevalence compared to after-hatch-year hummingbirds (39.0%; p-value = 0.089. On average, the percentage of the long axis of the rachis occupied by mites for the outer rectrices (R4 and R5 was 19%, compared to 11% for inner rectrices (R1 and R2, a significant difference (p-value = <0.0001. There was a marginal lack of significance for symmetrical distribution of tail mites with the mean left side percentage of long axis of the rachis occupied by mites being 16% and very close to the mean right side score of 18% (p-value = 0.003. The identification of the feather mite species was based on light microscopic morphometry, and mite distribution on feathers was further evaluated using tabletop scanning electron microscopy (TSEM. The hummingbird-feather mite relationship is not well understood

Hovering performance of Anna's hummingbirds (Calypte anna) in ground effect.

Science.gov (United States)

Kim, Erica J; Wolf, Marta; Ortega-Jimenez, Victor Manuel; Cheng, Stanley H; Dudley, Robert

2014-09-06

Aerodynamic performance and energetic savings for flight in ground effect are theoretically maximized during hovering, but have never been directly measured for flying animals. We evaluated flight kinematics, metabolic rates and induced flow velocities for Anna's hummingbirds hovering at heights (relative to wing length R = 5.5 cm) of 0.7R, 0.9R, 1.1R, 1.7R, 2.2R and 8R above a solid surface. Flight at heights less than or equal to 1.1R resulted in significant reductions in the body angle, tail angle, anatomical stroke plane angle, wake-induced velocity, and mechanical and metabolic power expenditures when compared with flight at the control height of 8R. By contrast, stroke plane angle relative to horizontal, wingbeat amplitude and wingbeat frequency were unexpectedly independent of height from ground. Qualitative smoke visualizations suggest that each wing generates a vortex ring during both down- and upstroke. These rings expand upon reaching the ground and present a complex turbulent interaction below the bird's body. Nonetheless, hovering near surfaces results in substantial energetic benefits for hummingbirds, and by inference for all volant taxa that either feed at flowers or otherwise fly close to plant or other surfaces. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

Vos, Faust, Voss: raakpunte tussen Vos deur Anna M. Louw en enkele ander tekste

Directory of Open Access Journals (Sweden)

P. John

2005-07-01

Full Text Available Vos, Faust, Voss: Points of contact between Vos by Anna M. Louw and selected other texts This article explores points of contact between “Vos” by Anna M. Louw and a number of related texts, including the following: the book “Job” from the Christian Bible, “Faust” by Goethe, “Voss” by Patrick White and texts forming part of the Gnostic tradition. The analysis describes similarities and differences, arguing that the implication of the points of contact between the various texts is that Vos suggests that the heritage of the Christian Reformation is not adequate for an understanding of life in South Africa, and it has to be supplemented with perspectives from other traditions.

Breast Cancer Heterogeneity Examined by High-Sensitivity Quantification of PIK3CA, KRAS, HRAS, and BRAF Mutations in Normal Breast and Ductal Carcinomas

Directory of Open Access Journals (Sweden)

Meagan B. Myers

2016-04-01

Full Text Available Mutant cancer subpopulations have the potential to derail durable patient responses to molecularly targeted cancer therapeutics, yet the prevalence and size of such subpopulations are largely unexplored. We employed the sensitive and quantitative Allele-specific Competitive Blocker PCR approach to characterize mutant cancer subpopulations in ductal carcinomas (DCs, examining five specific hotspot point mutations (PIK3CA H1047R, KRAS G12D, KRAS G12V, HRAS G12D, and BRAF V600E. As an approach to aid interpretation of the DC results, the mutations were also quantified in normal breast tissue. Overall, the mutations were prevalent in normal breast and DCs, with 9/9 DCs having measureable levels of at least three of the five mutations. HRAS G12D was significantly increased in DCs as compared to normal breast. The most frequent point mutation reported in DC by DNA sequencing, PIK3CA H1047R, was detected in all normal breast tissue and DC samples and was present at remarkably high levels (mutant fractions of 1.1 × 10−3 to 4.6 × 10−2 in 4/10 normal breast samples. In normal breast tissue samples, PIK3CA mutation levels were positively correlated with age. However, the PIK3CA H1047R mutant fraction distributions for normal breast tissues and DCs were similar. The results suggest PIK3CA H1047R mutant cells have a selective advantage in breast, contribute to breast cancer susceptibility, and drive tumor progression during breast carcinogenesis, even when present as only a subpopulation of tumor cells.

Characterization of mutations of the phosphoinositide-3-kinase regulatory subunit, PIK3R2, in perisylvian polymicrogyria: a next generation sequencing study

Science.gov (United States)

Mirzaa, Ghayda; Conti, Valerio; Timms, Andrew E.; Smyser, Christopher D.; Ahmed, Sarah; Carter, Melissa; Barnett, Sarah; Hufnagel, Robert B.; Goldstein, Amy; Narumi-Kishimoto, Yoko; Olds, Carissa; Collins, Sarah; Johnston, Kathreen; Deleuze, Jean-François; Nitschké, Patrick; Friend, Kathryn; Harris, Catharine; Goetsch, Allison; Martin, Beth; Boyle, Evan August; Parrini, Elena; Mei, Davide; Tattini, Lorenzo; Slavotinek, Anne; Blair, Ed; Barnett, Christopher; Shendure, Jay; Chelly, Jamel; Dobyns, William B.; Guerrini, Renzo

2015-01-01

SUMMARY Background Bilateral perisylvian polymicrogyria (BPP), the most common form of regional polymicrogyria, causes the congenital bilateral perisylvian syndrome, featuring oromotor dysfunction, cognitive impairment and epilepsy. BPP is etiologically heterogeneous, but only a few genetic causes have been reported. The aim of this study was to identify additional genetic etiologies of BPP and delineate their frequency in this patient population. Methods We performed child-parent (trio)-based whole exome sequencing (WES) on eight children with BPP. Following the identification of mosaic PIK3R2 mutations in two of these eight children, we performed targeted screening of PIK3R2 in a cohort of 118 children with BPP who were ascertained from 1980 until 2015 using two methods. First, we performed targeted sequencing of the entire PIK3R2 gene by single molecule molecular inversion probes (smMIPs) on 38 patients with BPP with normal-large head size. Second, we performed amplicon sequencing of the recurrent PIK3R2 mutation (p.Gly373Arg) on 80 children with various types of polymicrogyria including BPP. One additional patient underwent clinical WES independently, and was included in this study given the phenotypic similarity to our cohort. All patients included in this study were children (BPP. Of the 38 patients with BPP and normal-large head size who underwent targeted next generation sequencing by smMIPs, we identified constitutional and mosaic PIK3R2 mutations in 17 additional children. In parallel, one patient was found to have the recurrent PIK3R2 mutation by clinical WES. Seven patients had BPP alone, and 13 had BPP in association with features of the megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome (MPPH). Nineteen patients had the same mutation (Gly373Arg), and one had a nearby missense mutation (p.Lys376Glu). Across the entire cohort, mutations were constitutional in 12 and mosaic in eight patients. Among mosaic patients, we observed substantial

Improved waste water polishing in the North Anna clarifier using Durasil ion exchange media

International Nuclear Information System (INIS)

Hensley, M.C.; Sutter, H.G.

1986-01-01

On December 26, 1985, forty-one cubic feet of ion exchange media provided by Duratek was loaded into the North Anna clarifier demineralizer. As of the writing of this manuscript (February 6, 1986), processing using this single loading has continued for 42 straight days without breakthrough. To date, some 5.89 million gallons have been processed at an average flow rate of 140,200 gal/day. Throughputs are 143,700 gal/cu.ft. and still climbing. These figures represent improvements of a factor 20 over the run times experienced with organic resins immediately prior to the introduction of the new materials. This paper describes the testing program of Durasil ion exchange media carried out at North Anna by Duratek which lead to this dramatic improvement in performance

Abjeção em textos de André Sant’Anna

Directory of Open Access Journals (Sweden)

Leandro Salgueirinho

2009-07-01

Full Text Available Trata-se de uma leitura de textos do escritor André Sant’Anna a partir da problematização que, em The Return of the Real (1986, o crítico de arte norte-americano Hal Foster faz da noção de abjeto e da dita abject art.

The status of the PIK reactor

Energy Technology Data Exchange (ETDEWEB)

Petrov, Yu V [Academy of Sciences of Russia, Petersburg Nuclear Physics Institute, Gatchina, St. Petersburg (Russian Federation)

1992-07-01

This report describes the 100 MW research reactor PIK which is now under construction. The thermal neutron flux in the heavy water reflector exceeds 10{sup 15} cm{sup -2}s{sup -1}; in the light water trap, it is about 4{center_dot}10{sup 15} cm{sup -2}s{sup -1}. The replaceable core vessel allows to vary the parameters of the core over a wide range. The reactor provides sources of hot, cold and ultracold neutrons for 10 horizontal, 6 inclined neutron beams, and 8 neutron guides. At the ends of the beam tubes, the neutron flux is 10{sup 10} - 10{sup 11} cm{sup -2}s{sup -1}. The flux of the long wave neutrons exceeds 10{sup 9} cm{sup -2}s{sup -1}. To ensure precise measurements, the experimental hall is protected against vibrations. The project meets all modern safety requirements. The calculated parameters of the reactor were verified using a full-scale mock-up. Seventy percent of the reactor construction and installation were completed in the beginning of 1992. (author)

Anna Groundwater, The Scottish Middle March 1573-1625: Power, Kinship, Allegiance

OpenAIRE

Janine van Vliet

2011-01-01

Anna Groundwater. The Scottish Middle March 1573-1625: Power, Kinship, Allegiance. Royal Historical Society Studies in History, New Series. Woodbridge, UK: The Boydell Press, 2010. Pp. 236. ISBN 978-0-86193-307-5. £50.00; US$90.00.

PRKCI negatively regulates autophagy via PIK3CA/AKT–MTOR signaling

Energy Technology Data Exchange (ETDEWEB)

Qu, Liujing; Li, Ge; Xia, Dan; Hongdu, Beiqi; Xu, Chentong; Lin, Xin [Key Laboratory of Medical Immunology, Ministry of Health, Peking University Health Sciences Center, Beijing (China); Peking University Center for Human Disease Genomics, Peking University, Beijing (China); Chen, Yingyu, E-mail: yingyu_chen@bjmu.edu.cn [Key Laboratory of Medical Immunology, Ministry of Health, Peking University Health Sciences Center, Beijing (China); Peking University Center for Human Disease Genomics, Peking University, Beijing (China)

2016-02-05

The atypical protein kinase C isoform PRKC iota (PRKCI) plays a key role in cell proliferation, differentiation, and carcinogenesis, and it has been shown to be a human oncogene. Here, we show that PRKCI overexpression in U2OS cells impaired functional autophagy in normal or cell stress conditions, as characterized by decreased levels of light chain 3B-II protein (LC3B-II) and weakened degradation of endogenous and exogenous autophagic substrates. Conversely, PRKCI knockdown by small interference RNA resulted in opposite effects. Additionally, we identified two novel PRKCI mutants, PRKCI{sup L485M} and PRKCI{sup P560R}, which induced autophagy and exhibited dominant negative effects. Further studies indicated that PRKCI knockdown–mediated autophagy was associated with the inactivation of phosphatidylinositol 3-kinase alpha/AKT–mammalian target of rapamycin (PIK3CA/AKT–MTOR) signaling. These data underscore the importance of PRKCI in the regulation of autophagy. Moreover, the finding may be useful in treating PRKCI-overexpressing carcinomas that are characterized by increased levels of autophagy. - Highlights: • The atypical protein kinase C iota isoform (PRKCI) is a human oncogene. • PRKCI overexpression impairs functional autophagy in U2OS cells. • It reduces LC3B-II levels and weakens SQSTM1 and polyQ80 aggregate degradation. • PRKCI knockdown has the opposite effect. • The effect of PRKCI knockdown is related to PIK3CA/AKT–MTOR signaling inactivation.

The Potsdam Parallel Ice Sheet Model (PISM-PIK) - Part 1: Model description

Science.gov (United States)

Winkelmann, R.; Martin, M. A.; Haseloff, M.; Albrecht, T.; Bueler, E.; Khroulev, C.; Levermann, A.

2011-09-01

We present the Potsdam Parallel Ice Sheet Model (PISM-PIK), developed at the Potsdam Institute for Climate Impact Research to be used for simulations of large-scale ice sheet-shelf systems. It is derived from the Parallel Ice Sheet Model (Bueler and Brown, 2009). Velocities are calculated by superposition of two shallow stress balance approximations within the entire ice covered region: the shallow ice approximation (SIA) is dominant in grounded regions and accounts for shear deformation parallel to the geoid. The plug-flow type shallow shelf approximation (SSA) dominates the velocity field in ice shelf regions and serves as a basal sliding velocity in grounded regions. Ice streams can be identified diagnostically as regions with a significant contribution of membrane stresses to the local momentum balance. All lateral boundaries in PISM-PIK are free to evolve, including the grounding line and ice fronts. Ice shelf margins in particular are modeled using Neumann boundary conditions for the SSA equations, reflecting a hydrostatic stress imbalance along the vertical calving face. The ice front position is modeled using a subgrid-scale representation of calving front motion (Albrecht et al., 2011) and a physically-motivated calving law based on horizontal spreading rates. The model is tested in experiments from the Marine Ice Sheet Model Intercomparison Project (MISMIP). A dynamic equilibrium simulation of Antarctica under present-day conditions is presented in Martin et al. (2011).

Ernst Julius Öpik's (1916) note on the theory of explosion cratering on the Moon's surface—The complex case of a long-overlooked benchmark paper

Science.gov (United States)

Racki, Grzegorz; Koeberl, Christian; Viik, Tõnu; Jagt-Yazykova, Elena A.; Jagt, John W. M.

2014-10-01

High-velocity impact as a common phenomenon in planetary evolution was ignored until well into the twentieth century, mostly because of inadequate understanding of cratering processes. An eight-page note, published in Russian by the young Ernst Julius Öpik, a great Estonian astronomer, was among the key selenological papers, but due to the language barrier, it was barely known and mostly incorrectly cited. This particular paper is here intended to serve as an explanatory supplement to an English translation of Öpik's article, but also to document an early stage in our understanding of cratering. First, we outline the historical-biographical background of this benchmark paper, and second, a comprehensive discussion of its merits is presented, from past and present perspectives alike. In his theoretical research, Öpik analyzed the explosive formation of craters numerically, albeit in a very simple way. For the first time, he approximated relationships among minimal meteorite size, impact energy, and crater diameter; this scaling focused solely on the gravitational energy of excavating the crater (a "useful" working approach). This initial physical model, with a rational mechanical basis, was developed in a series of papers up to 1961. Öpik should certainly be viewed as the founder of the numerical simulation approach in planetary sciences. In addition, the present note also briefly describes Nikolai A. Morozov as a remarkable man, a forgotten Russian scientist and, surprisingly, the true initiator of Öpik's explosive impact theory. In fact, already between 1909 and 1911, Morozov probably was the first to consider conclusively that explosion craters would be circular, bowl-shaped depressions even when formed under different impact angles.

Scale-4 analysis of pressurized water reactor critical configurations: Volume 5, North Anna Unit 1 Cycle 5

International Nuclear Information System (INIS)

Bowman, S.M.; Suto, T.

1996-10-01

ANSI/ANS 8.1 requires that calculational methods for away-from- reactor (AFR) criticality safety analyses be validated against experiment. This report summarizes part of the ongoing effort to benchmark AFR criticality analysis methods using selected critical configurations from commercial PWRs. Codes and data in the SCALE-4 code system were used. This volume documents the SCALE system analysis of one reactor critical configuration for North Anna Unit 1 Cycle 5. The KENO V.a criticality calculations for the North Anna 1 Cycle 5 beginning-of-cycle model yielded a value for k eff of 1. 0040±0.0005

PIK3CA-associated developmental disorders exhibit distinct classes of mutations with variable expression and tissue distribution

NARCIS (Netherlands)

Mirzaa, Ghayda; Timms, Andrew E.; Conti, Valerio; Boyle, Evan August; Girisha, Katta M.; Martin, Beth; Kircher, Martin; Olds, Carissa; Juusola, Jane; Collins, Sarah; Park, Kaylee; Carter, Melissa; Glass, Ian; Krägeloh-Mann, Inge; Chitayat, David; Parikh, Aditi Shah; Bradshaw, Rachael; Torti, Erin; Braddock, Stephen; Burke, Leah; Ghedia, Sondhya; Stephan, Mark; Stewart, Fiona; Prasad, Chitra; Napier, Melanie; Saitta, Sulagna; Straussberg, Rachel; Gabbett, Michael; O'Connor, Bridget C.; Keegan, Catherine E.; Yin, Lim Jiin; Lai, Angeline Hwei Meeng; Martin, Nicole; McKinnon, Margaret; Addor, Marie-Claude; Boccuto, Luigi; Schwartz, Charles E.; Lanoel, Agustina; Conway, Robert L.; Devriendt, Koenraad; Tatton-Brown, Katrina; Pierpont, Mary Ella; Painter, Michael; Worgan, Lisa; Reggin, James; Hennekam, Raoul; Tsuchiya, Karen; Pritchard, Colin C.; Aracena, Mariana; Gripp, Karen W.; Cordisco, Maria; Esch, Hilde Van; Garavelli, Livia; Curry, Cynthia; Goriely, Anne; Kayserilli, Hulya; Shendure, Jay; Graham, John; Guerrini, Renzo; Dobyns, William B.

2016-01-01

Mosaicism is increasingly recognized as a cause of developmental disorders with the advent of next-generation sequencing (NGS). Mosaic mutations of PIK3CA have been associated with the widest spectrum of phenotypes associated with overgrowth and vascular malformations. We performed targeted NGS

Mass-spectrometer of knock-on nuclei for reactor 'Pik'

International Nuclear Information System (INIS)

Begzhanov, P.B.; Nazarov, A.G.; Petrov, G.A.; Pikul', V.P.

1999-01-01

For reactor 'Pik' (that is being built in St. Petersburg Institute of Nuclear Physics) there was designed a universal two shoulder mass-spectrometer for non-decelerated fission products (FP) of nuclei. The spectrometer helps to obtain different values of linear magnification, dispersion, aberration coefficients and transmission without making structural changes in the device. To separate FP for one shoulder of spectrometer we chose ion-optical scheme (IOS) consisting of three electrostatic analyzers and three-sectional magnet 'JOSEF' that had high dispersion by masses at small deflection radius. IOS calculations of mass-spectrometer were performed with the help of program TRANSVOL (transfer of phase volume) designed basing on TRIO program. The program allows calculating of complete IOS transmission with taking into account elements aperture and beam officering

Two design aspects connected with the safety of the PIK reactor presently under construction

International Nuclear Information System (INIS)

Gostev, V.V.; Zakharov, A.S.; Konoplev, K.A.; Levandovskii, N.V.; Ploshchanskii, L.M.; Smolsky, S.L.

1993-01-01

The PIK reactor is designed for physical research with neutron beams and sample irradiation. In the central trap the thermal neutrons flux is 4x10 15 n/cm 2 s. The reactor power is 100 MW, the thermal neutron flux in the reflector at the maximum of distribution is 1x10 15 n/cm 2 s. The core with a high uranium concentration of 600 g/l is light water-cooled, heavy water being used in the reflector. The Chernobyl disaster happened at the time of equipment installation at the PIK. The code revision, a change of the authors ideas about the safety, and a change of public attitude towards nuclear installations resulted in a stopping of construction and project revision. Reconstruction project has led to a change of all safety systems and involved in various degrees all essential reactor systems. The construction is presently resumed in spite of economic difficulties in Russia. The reactor was inspected by experts from a number of European countries, USA, and European Commission delegated by their governments to prepare a report on whether supporting the construction to its completion would be reasonable. In the course of inspection the experts from USA and EU expressed doubts concerning two systems, namely, the containment and scram. These two points are discussed in the present paper. Three type of containments are proposed and an analysis of their efficiency is presented. The PIK reactor is controlled by eight rods in the heavy-water reflector -and an absorbing cylinder at the boundary between the core and the central light-water neutron trap. The rods are used for emergency protection and reactor start-up. The central control cylinder called here the shutter serves several functions, namely, as scram, automatic control, and burnup compensation. The delay time before the onset of negative reactivity is 1.05 sec for rods and 0.25 sec for the shutter

Clinical Holistic Medicine: The Case Story of Anna. II. Patient Diary as a Tool in Treatment

Directory of Open Access Journals (Sweden)

Sören Ventegodt

2006-01-01

Full Text Available In spite of extreme childhood sexual and violent abuse, a 22-year-old young woman, Anna, healed during holistic existential therapy. New and highly confrontational therapeutic tools were developed and used to help this patient (like acceptance through touch and acupressure through the vagina. Her vulva and introitus were scarred from repeated brutal rape, as was the interior of her mouth. During therapy, these scars were gently contacted and the negative emotional contents released. The healing was in accordance with the advanced holistic medical toolbox that uses (1 love, (2 trust, (3 holding, and (4 helping the patient to process and integrate old traumas.The case story clearly revealed the philosophical adjustments that Anna made during treatment in response to the severe childhood abuse. These adjustments are demonstrated by her diary, where sentences contain both the feelings and thoughts of the painful present (the gestalt at the time of the abuse, thus containing the essence of the traumas, making the repression of the painful emotions possible through the change in the patient’s philosophical perspective. Anna's case gives a unique insight into the process of traumatization (pathogenesis and the process of healing (salutogenesis. At the end of the healing, Anna reconnected her existence to the outer world in a deep existential, suicidal crisis and faced her choice of life or death. She decided to live and, in this process, assumed existential responsibility, which made her able to step out of her mental disease. The advanced holistic toolbox seems to help patients heal even from the worst childhood abuse. In spite of the depth of the existential crisis, holistic existential therapy seems to support existential responsibility well and thus safe for the patients.

Muscle activation patterns and motor anatomy of Anna's hummingbirds Calypte anna and zebra finches Taeniopygia guttata.

Science.gov (United States)

Donovan, Edward R; Keeney, Brooke K; Kung, Eric; Makan, Sirish; Wild, J Martin; Altshuler, Douglas L

2013-01-01

Flying animals exhibit profound transformations in anatomy, physiology, and neural architecture. Although much is known about adaptations in the avian skeleton and musculature, less is known about neuroanatomy and motor unit integration for bird flight. Hummingbirds are among the most maneuverable and specialized of vertebrate fliers, and two unusual neuromuscular features have been previously reported: (1) the pectoralis major has a unique distribution pattern of motor end plates (MEPs) compared with all other birds and (2) electromyograms (EMGs) from the hummingbird's pectoral muscles, the pectoralis major and the supracoracoideus, show activation bursts composed of one or a few spikes that appear to have a very consistent pattern. Here, we place these findings in a broader context by comparing the MEPs, EMGs, and organization of the spinal motor neuron pools of flight muscles of Anna's hummingbird Calypte anna, zebra finches Taeniopygia guttata, and, for MEPs, several other species. The previously shown MEP pattern of the hummingbird pectoralis major is not shared with its closest taxonomic relative, the swift, and appears to be unique to hummingbirds. MEP arrangements in previously undocumented wing muscles show patterns that differ somewhat from other avian muscles. In the parallel-fibered strap muscles of the shoulder, MEP patterns appear to relate to muscle length, with the smallest muscles having fibers that span the entire muscle. MEP patterns in pennate distal wing muscles were the same regardless of size, with tightly clustered bands in the middle portion of the muscle, not evenly distributed bands over the muscle's entire length. Muscle activations were examined during slow forward flight in both species, during hovering in hummingbirds, and during slow ascents in zebra finches. The EMG bursts of a wing muscle, the pronator superficialis, were highly variable in peak number, size, and distribution across wingbeats for both species. In the pectoralis

Influence of canopy form on growth, flowering, and storage potential of ,anna, apple

International Nuclear Information System (INIS)

Zahran, A.A.

2000-01-01

this study was carried out during the two successive seasons of 1997 and 1998. two years old anna apple trees (budded on M.M. 106 semi - dwarfing root - stocks) planted in El Khattatbah, Monoufiah Governorate were used in this investigation. this study aimed to evaluate the influence of two different tree canopy forms (central leaders and vase) and tipping treatment on the yield and some fruit quality characteristics of anna apple fruits and the effect of irradiation on some of these characteristics during a limited period under cold storage. results revealed improved light conditions in trained trees compared to untrained controls. open vase trained trees produce less fruits which where bigger, softer, with more T.S.S. and sugar content, and less acidity, compared to central leader harvested fruits.it was also found that tipping application resulted in excessive vegetative growth and reduced fruit numbers which were bigger, softer, and contained more T.S.S., and sugars, and less acidity, compared to fruits harvested from untipped trees

Anna Politkovskaya: Rússlands Pútíns

Directory of Open Access Journals (Sweden)

Pétur Berg Matthíasson

2009-12-01

Full Text Available Í umsögn gagnrýnanda kemur meðal annars eftirfarandi fram: Fram kemur í lok bókarinnar að Anna hafi illan bifur á Pútín. Það kemur lesandanum í sjálfu sér ekki á óvart enda bókin upptalning á skelfilegum atburðum sem lýsa hvers konar stjórnvöldum hann fer fyrir, fyrir utan það að Pútín gerir lítið sem ekkert til að breyta því til hins betra. Þessi bók er nauðsynleg fyrir alla þá sem vilja skyggnast bak við tjöldin og sjá Rússland eins og það er í raun og veru.

“Speaking German Like Nobody’s Business”: Anna May Wong, Walter Benjamin, and the Possibilities of Asian American Cosmopolitanism

OpenAIRE

Lim, Shirley Jennifer

2012-01-01

In the summer of 1928 in Berlin, the noted German Jewish philosopher Walter Benjamin (1892–1940) and Chinese American actress Anna May Wong (1905–1961) shared an unlikely encounter that set in relief European and American conceptions of modernity as well as white European intellectual and American racial minority cosmopolitanisms. On July 6, 1928, Benjamin published the results as “Gespräch mit Anne May Wong” [“Speaking with Anna May Wong: A Chinoiserie from the Old West”] on the front page o...

Physical and geometrical parameters of ANNA critical assemblies. Pt. 2

International Nuclear Information System (INIS)

Malewski, S.; Dabrowski, C.

1973-01-01

An extended analysis of four critical configurations of ANNA Assembly has been performed. Diffusion parameters of the thermal group and of one or three epithermal groups have been determined. Using these data the critical calculations have been carried out and the main neutron density distributions presented. The role of some neutron processes in these systems and their influence on integral parameters has been considered. The calculated quantities have been compared with the available experimental data. (author)

Anna Pavlova, danzatrice eurasiana? (I parte

Directory of Open Access Journals (Sweden)

Silvia Mei

2010-12-01

Full Text Available Abstract – IT Prima diva nella costellazione di nuove star dello spettacolo novecentesco, Anna Pavlova visse unicamente nello spirito e nella missione della danza come forma d’arte e stile di vita. Senza temere i rischi del solipsismo, si lancia nell’avventura di una compagnia tutta sua dopo il clamore parigino dei Ballets Russes. Il suo coraggio, la sua curiosità, il suo genio artistico la portano a viaggiare per i cinque continenti senza sosta, a scoprire danze tradizionali, a praticarle essa stessa, come quelle kabuki, apprese non senza sofferenze in Giappone nel 1922. Presentata nella vulgata come paladina della tradizione classicoaccademica, Pavlova può ostentare una biografia degna delle grandi danzatrici moderne a lei contemporanee, come una Duncan o una Ruth St. Denis (con quest’ultima in rapporto di competizione a distanza intorno al soggetto di Radha. Insieme ad una figura controversa e intrigante come quella del danzatore indiano Uday Shankar, crea un trittico di danze di ispirazione orientale all’insegna del rigore filologico e dell’integrazione linguistica, traccia della sua apertura e del rispetto di tradizioni teatrali altre. Abstract – EN Anna Pavlova, the first diva within the stars firmament of the 20th century, spent her life exclusively in the spirit of dance, intended as an art form and a life style, as if it were a mission. She threw herself into the adventure of leading her own company, after the Ballets Russes' European acclaim. Her courage, curiosity and artistic genius took her through five continents, endlessly searching for traditional dances that she learned with tremendous physical suffering, as in Japan with kabuki in 1922. She’s not simply a paladin of the academic tradition. She can in fact claim a biography and dance practice worthy of the most famous modern dancers who lived in her age, such as Duncan and St. Denis (with whom she was in a special competition, though after years, on the subject

Latin and knitting. Educational and biographical experiences in «My life» by Anna Franchi

Directory of Open Access Journals (Sweden)

Lucilla Gigli

2014-01-01

Full Text Available The life and works of Anna Franchi remained undiscovered for a long time despite the writer desired to become part of history and to leave a trace both in the socialist and in the emancipa­tionist movements. In the literary production of Anna Franchi, autobiographical elements and fictions become an inseparable issue. Particularly in her biography La mia vita (My life pub­lished for the first time in 1940 the writer looked through her life searching for a deeper meaning. Franchi does not limit to describe events and characters but, through narration, she gives an interpretation of her own experience giving in the same time a meaning to it: from her childhood when she ab­sorbs and adopts the ideals of the Risorgimento and the love for art and literature to the long and extremely painful period of her marriage; from journalistic and artistic activities to the political commitment with the socialist party and the movement for women’s rights. Through her works, Franchi provides a political example of free woman Received: 27/05/2013 / Accepted: 20/06/2013 How to reference this article Gigli, L. (2014. Latino e calza. Educazione ed esperienze biografiche ne «La mia vita» di Anna Franchi. Espacio, Tiempo y Educación, 1(1, pp. 97-113. doi: http://dx.doi.org/10.14516/ete.2014.001.001.005

Auxiliary feedwater system risk-based inspection guide for the North Anna nuclear power plants

International Nuclear Information System (INIS)

Nickolaus, J.R.; Moffitt, N.E.; Gore, B.F.; Vo, T.V.

1992-10-01

In a study sponsored by the US Nuclear regulatory Commission (NRC), Pacific Northwest Laboratory has developed and applied a methodology for deriving plant-specific risk-based inspection guidance for the auxiliary feedwater (AFW) system at pressurized water reactors that have not undergone probabilistic risk assessment (PRA). This methodology uses existing PRA results and plant operating experience information. Existing PRA-based inspection guidance information recently developed for the NRC for various plants was used to identify generic component failure modes. This information was then combined with plant-specific and industry-wide component information and failure data to identify failure modes and failure mechanisms for the AFW system at the selected plants. North Anna was selected as a plant for study. The product of this effort is a prioritized listing of AFW failures which have occurred at the plant and at other PWRs. This listing is intended for use by the NRC inspectors in preparation of inspection plans addressing AFW risk important components at the North Anna plant

microRNA 126 inhibits the transition of endothelial progenitor cells to mesenchymal cells via the PIK3R2-PI3K/Akt signalling pathway.

Science.gov (United States)

Zhang, Junfeng; Zhang, Zongqi; Zhang, David Y; Zhu, Jianbing; Zhang, Tiantian; Wang, Changqian

2013-01-01

Endothelial progenitor cells (EPCs) are capable of proliferating and differentiating into mature endothelial cells, and they have been considered as potential candidates for coronary heart disease therapy. However, the transition of EPCs to mesenchymal cells is not fully understood. This study aimed to explore the role of microRNA 126 (miR-126) in the endothelial-to-mesenchymal transition (EndMT) induced by transforming growth factor beta 1 (TGFβ1). EndMT of rat bone marrow-derived EPCs was induced by TGFβ1 (5 ng/mL) for 7 days. miR-126 expression was depressed in the process of EPC EndMT. The luciferase reporter assay showed that the PI3K regulatory subunit p85 beta (PIK3R2) was a direct target of miR-126 in EPCs. Overexpression of miR-126 by a lentiviral vector (lenti-miR-126) was found to downregulate the mRNA expression of mesenchymal cell markers (α-SMA, sm22-a, and myocardin) and to maintain the mRNA expression of progenitor cell markers (CD34, CD133). In the cellular process of EndMT, there was an increase in the protein expression of PIK3R2 and the nuclear transcription factors FoxO3 and Smad4; PI3K and phosphor-Akt expression decreased, a change that was reversed markedly by overexpression of miR-126. Furthermore, knockdown of PIK3R2 gene expression level showed reversed morphological changes of the EPCs treated with TGFβ1, thereby giving the evidence that PIK3R2 is the target gene of miR-126 during EndMT process. These results show that miR-126 targets PIK3R2 to inhibit EPC EndMT and that this process involves regulation of the PI3K/Akt signalling pathway. miR-126 has the potential to be used as a biomarker for the early diagnosis of intimal hyperplasia in cardiovascular disease and can even be a therapeutic tool for treating cardiovascular diseases mediated by the EndMT process.

The Potsdam Parallel Ice Sheet Model (PISM-PIK – Part 1: Model description

Directory of Open Access Journals (Sweden)

R. Winkelmann

2011-09-01

Full Text Available We present the Potsdam Parallel Ice Sheet Model (PISM-PIK, developed at the Potsdam Institute for Climate Impact Research to be used for simulations of large-scale ice sheet-shelf systems. It is derived from the Parallel Ice Sheet Model (Bueler and Brown, 2009. Velocities are calculated by superposition of two shallow stress balance approximations within the entire ice covered region: the shallow ice approximation (SIA is dominant in grounded regions and accounts for shear deformation parallel to the geoid. The plug-flow type shallow shelf approximation (SSA dominates the velocity field in ice shelf regions and serves as a basal sliding velocity in grounded regions. Ice streams can be identified diagnostically as regions with a significant contribution of membrane stresses to the local momentum balance. All lateral boundaries in PISM-PIK are free to evolve, including the grounding line and ice fronts. Ice shelf margins in particular are modeled using Neumann boundary conditions for the SSA equations, reflecting a hydrostatic stress imbalance along the vertical calving face. The ice front position is modeled using a subgrid-scale representation of calving front motion (Albrecht et al., 2011 and a physically-motivated calving law based on horizontal spreading rates. The model is tested in experiments from the Marine Ice Sheet Model Intercomparison Project (MISMIP. A dynamic equilibrium simulation of Antarctica under present-day conditions is presented in Martin et al. (2011.

The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer.

Directory of Open Access Journals (Sweden)

Jatin Roper

Full Text Available To examine the in vitro and in vivo efficacy of the dual PI3K/mTOR inhibitor NVP-BEZ235 in treatment of PIK3CA wild-type colorectal cancer (CRC.PIK3CA mutant and wild-type human CRC cell lines were treated in vitro with NVP-BEZ235, and the resulting effects on proliferation, apoptosis, and signaling were assessed. Colonic tumors from a genetically engineered mouse (GEM model for sporadic wild-type PIK3CA CRC were treated in vivo with NVP-BEZ235. The resulting effects on macroscopic tumor growth/regression, proliferation, apoptosis, angiogenesis, and signaling were examined.In vitro treatment of CRC cell lines with NVP-BEZ235 resulted in transient PI3K blockade, sustained decreases in mTORC1/mTORC2 signaling, and a corresponding decrease in cell viability (median IC(50 = 9.0-14.3 nM. Similar effects were seen in paired isogenic CRC cell lines that differed only in the presence or absence of an activating PIK3CA mutant allele. In vivo treatment of colonic tumor-bearing mice with NVP-BEZ235 resulted in transient PI3K inhibition and sustained blockade of mTORC1/mTORC2 signaling. Longitudinal tumor surveillance by optical colonoscopy demonstrated a 97% increase in tumor size in control mice (p = 0.01 vs. a 43% decrease (p = 0.008 in treated mice. Ex vivo analysis of the NVP-BEZ235-treated tumors demonstrated a 56% decrease in proliferation (p = 0.003, no effects on apoptosis, and a 75% reduction in angiogenesis (p = 0.013.These studies provide the preclinical rationale for studies examining the efficacy of the dual PI3K/mTOR inhibitor NVP-BEZ235 in treatment of PIK3CA wild-type CRC.

A comparison of Zircaloy oxide thicknesses on Millstone-3 and North Anna-1 PWR fuel cladding

International Nuclear Information System (INIS)

Polley, M.V.; Evans, H.E.

1993-08-01

High concentrations of lithium in the coolant may enhance the corrosion rate of Zircaloy fuel cladding. In the present work, oxide thicknesses on fuel cladding from the Millstone 3 PWR were compared with those from the North Anna 1 PWR. The intention was to identify whether the higher lithium levels (up to 3.5 ppM) in the Millstone 3 primary coolant during cycles 2 and 3 led to significantly greater oxidation rates than in North Anna 1 which operated generally with lithium levels lower than 2.2 ppM. The comparisons were made by comparing the measurements with code predictions of Zircaloy oxidation in order to factor out the effect of operational variables on the oxide thicknesses achieved. Overall, Millstone 3 oxide thicknesses were found to be approximately 14% greater than North Anna 1 values. However, approximately 29% lower oxide thicknesses were found on reload Millstone 3 rods exposed to one cycle of elevated lithium chemistry than on Millstone 3 initial fuel exposed to one cycle of normal lithium chemistry during cycle 1. Furthermore, oxide thicknesses on Millstone 3 rods exposed to two cycles of elevated lithium chemistry were approximately 36% lower than on Millstone 3 rods exposed to one cycle of normal lithium chemistry plus one cycle of elevated lithium chemistry. Therefore, it cannot be concluded that elevated lithium operation in Millstone 3 led to enhanced Zircaloy fuel clad corrosion

Anna Lampérière, solidarité et citoyenneté féminine sous la Troisième République

Directory of Open Access Journals (Sweden)

Anne R. Epstein

2008-12-01

Full Text Available Cet article examine les idées de l’institutrice Anna Lampérière, l’une des rares femmes à avoir contribué à la discussion théorique sur l’idéologie de la solidarité pendant la Troisième République. Vue dans le contexte de son parcours personnel et de son engagement civique, la pensée d’A. Lampérière offre un aperçu inédit d’un modèle solidariste de citoyenneté féminine sans droit de vote. Au sein d’une culture d’associations florissante au début du XXe siècle, elle participe à la création et au fonctionnement d’importantes associations mixtes qui, par l’éducation civique, visent la mise en place de l’idéologie solidariste de Léon Bourgeois. Se proclamant anti-féministe, Anna Lampérière se présente néanmoins comme une défenseuse de la cause des femmes et du progrès social et, comme beaucoup de ses contemporains, elle place la réforme scolaire au cœur de son projet républicain. Après une analyse de la vision sociale d’Anna Lampérière, l’article examine les pratiques civiques et la structure mixte selon les sexes de la Société pour l’éducation sociale, une association pour la promotion du solidarisme, dont elle a été Secrétaire générale. L’idéologie solidariste et sa pratique avaient un attrait pour des femmes républicaines comme Anna Lampérière qui avaient une vocation civique mais qui n’étaient pas attirées par un modèle égalitaire de la citoyenneté.Anna Lampérière, solidarité and female citizenship in the Third Republic This article explores the ideas of educator Anna Lampérière, one of the rare women to contribute significantly to the theoretical discussion about the ideology of solidarity during the Third Republic. Viewed in tandem with her own personal history and civic activism, Lampérière’s thought provides unique insight into a possible solidarist model of female citizenship without voting rights. Operating within the flourishing associational

KR’PTA. Samtidspoesin och Derrida : Spår och ärrbildningar hos Johannes Heldén, Ingrid Storholmen och Anna Hallberg

OpenAIRE

Schmidt, Lisa

2006-01-01

Lisa Schmidt, KR’PTA. Samtidspoesin och Derrida. Spår och ärrbildningar hos Johannes Hel­dén, Ingrid Storholmen och Anna Hallberg. (CR’PT. Contemporary Poetry and Derrida: Traces and Scarring in the Poetry of Johannes Heldén, Ingrid Storholmen and Anna Hallberg.) Through the analyses of three contemporary Nordic poets whose work challenges the boun­daries of literature and even the laws of grammar, I draw attention to the term linguistic materialism. I also sketch an historical line between t...

microRNA 126 inhibits the transition of endothelial progenitor cells to mesenchymal cells via the PIK3R2-PI3K/Akt signalling pathway.

Directory of Open Access Journals (Sweden)

Junfeng Zhang

Full Text Available AIMS: Endothelial progenitor cells (EPCs are capable of proliferating and differentiating into mature endothelial cells, and they have been considered as potential candidates for coronary heart disease therapy. However, the transition of EPCs to mesenchymal cells is not fully understood. This study aimed to explore the role of microRNA 126 (miR-126 in the endothelial-to-mesenchymal transition (EndMT induced by transforming growth factor beta 1 (TGFβ1. METHODS AND RESULTS: EndMT of rat bone marrow-derived EPCs was induced by TGFβ1 (5 ng/mL for 7 days. miR-126 expression was depressed in the process of EPC EndMT. The luciferase reporter assay showed that the PI3K regulatory subunit p85 beta (PIK3R2 was a direct target of miR-126 in EPCs. Overexpression of miR-126 by a lentiviral vector (lenti-miR-126 was found to downregulate the mRNA expression of mesenchymal cell markers (α-SMA, sm22-a, and myocardin and to maintain the mRNA expression of progenitor cell markers (CD34, CD133. In the cellular process of EndMT, there was an increase in the protein expression of PIK3R2 and the nuclear transcription factors FoxO3 and Smad4; PI3K and phosphor-Akt expression decreased, a change that was reversed markedly by overexpression of miR-126. Furthermore, knockdown of PIK3R2 gene expression level showed reversed morphological changes of the EPCs treated with TGFβ1, thereby giving the evidence that PIK3R2 is the target gene of miR-126 during EndMT process. CONCLUSIONS: These results show that miR-126 targets PIK3R2 to inhibit EPC EndMT and that this process involves regulation of the PI3K/Akt signalling pathway. miR-126 has the potential to be used as a biomarker for the early diagnosis of intimal hyperplasia in cardiovascular disease and can even be a therapeutic tool for treating cardiovascular diseases mediated by the EndMT process.

Kahevahel : Kui hajusad on kultuuriruumi piirid? / Anna Verschik, Tiina Kirss, Mikko Lagerspetz ; intervjueerinud Daniele Monticelli, Merle Karro-Kalberg

Index Scriptorium Estoniae

Verschik, Anna, 1968-

2015-01-01

Kultuurist, kultuuriruumist, kultuuris olemisest ja sealt pärinemisest arutlevad TLÜ professori Daniele Monticelli eestvõttel TLÜ professorid Anna Verschik ja Tiina Kirss ning Turu Åbo Akadeemia professor Mikko Lagerspetz

Paediatrics and psychoanalysis--Miss Anna Freud.

Science.gov (United States)

1983-01-01

Miss Anna Freud died during the winter at the age of 86. She had been a pioneer in the understanding of children through psychoanalysis and a great champion of the rights of children. Her life began in Vienna as the youngest child of Sigmund Freud, and her early work with children was in Austria. In 1938, because of the Nazi régime and even though she was nursing her father during his terminal illness, she had to escape with him to London. Her work with homeless children and with those in residential nurseries in London during the second world war is well known, as is her work on child development and psychopathology in the postwar years. But one less well known aspect of her life that was of immense importance to a few fortunate British paediatricians was the 'paediatric group' that she ran for over a quarter of a century and which Dr Christine Cooper recalled at the memorial meeting in London earlier this year. PMID:6344806

African American Women Scholars and International Research: Dr. Anna Julia Cooper's Legacy of Study Abroad

Science.gov (United States)

Evans, Stephanie Y.

2009-01-01

EIn this article, the author presents a little-known but detailed history of Black women's tradition of study abroad. Specifically, she situates Dr. Anna Julia Cooper within the landscape of historic African American students who studied in Japan, Germany, Jamaica, England, Italy, Haiti, India, West Africa, and Thailand, in addition to France. The…

Flying in the rain: hovering performance of Anna's hummingbirds under varied precipitation.

Science.gov (United States)

Ortega-Jimenez, Victor Manuel; Dudley, Robert

2012-10-07

Flight in rain represents a greater challenge for smaller animals because the relative effects of water loading and drop impact are greater at reduced scales given the increased ratios of surface area to mass. Nevertheless, it is well known that small volant taxa such as hummingbirds can continue foraging even in extreme precipitation. Here, we evaluated the effect of four rain intensities (i.e. zero, light, moderate and heavy) on the hovering performance of Anna's hummingbirds (Calypte anna) under laboratory conditions. Light-to-moderate rain had only a marginal effect on flight kinematics; wingbeat frequency of individuals in moderate rain was reduced by 7 per cent relative to control conditions. By contrast, birds hovering in heavy rain adopted more horizontal body and tail positions, and also increased wingbeat frequency substantially, while reducing stroke amplitude when compared with control conditions. The ratio between peak forces produced by single drops on a wing and on a solid surface suggests that feathers can absorb associated impact forces by up to approximately 50 per cent. Remarkably, hummingbirds hovered well even under heavy precipitation (i.e. 270 mm h(-1)) with no apparent loss of control, although mechanical power output assuming perfect and zero storage of elastic energy was estimated to be about 9 and 57 per cent higher, respectively, compared with normal hovering.

Accounting history and the feminine gender: The case Anna Jansen, Queen of Maranhão (19th Century

Directory of Open Access Journals (Sweden)

Eliane Silva Sampaio

2017-07-01

By analyzing the manuscripts and newspapers of the time it was concluded that Anna Jansen became the owner of one of the largest fortunes in the region after becoming the widow of her first husband, Coronel Izidoro Pereira, and through this fortune has achieved a prominent position in the Maranhão society. Her performance represents a breaking of paradigms that tend to cancel the participation of women in economic and political activities, and led to her recognition as a woman far ahead of the time in which she lived. Although it was not possible to find technical records kept by Anna Jansen throughout her life, it has been possible through primary documents to gain knowledge that she had great dexterity for the administration of her properties and assets.

Final environmental statement related to the operation of North Anna Power Station, Units 1 and 2: (Docket Nos. 50-338 and 50-339)

International Nuclear Information System (INIS)

1980-08-01

The proposed action is the issuance of Operating Licenses to the Virginia Electric and Power Company for the startup and operation of the North Anna Power Station, Units No. 1 and 2, located on Lake Anna in Louisa County, 40 miles east of Charlottesville, Virginia. The information in this second addendum responds to the Commission's directive that the staff address in narrative form the environmental dose commitments and health effects from fuel cycle releases, fuel cycle socioeconomic impacts, and possible cumulative impacts pending further treatment by rulemaking

North Anna Power Station - Unit 1: Overview of steam generator replacement project activities

International Nuclear Information System (INIS)

Gettler, M.W.; Bayer, R.K.; Lippard, D.W.

1993-01-01

The original steam generators at Virginia Electric and Power Company's (Virginia Power) North Anna Power Station (NAPS) Unit 1 have experienced corrosion-related degradation that require periodic inspection and plugging of steam generator tubes to ensure their continued safe and reliable operation. Despite improvements in secondary water chemistry, continued tube degradation in the steam generators necessitated the removal from service of approximately 20.3 percent of the tubes by plugging, (18.6, 17.3, and 25.1 for steam generators A, B, and C, respectively). Additionally, the unit power was limited to 95 % during, its last cycle of operation. Projections of industry and Virginia Power experience indicated the possibility of mid-cycle inspections and reductions in unit power. Therefore, economic considerations led to the decision to repair the steam generators (i.e., replace the steam generator lower assemblies). Three new Model 51F Steam Generator lower assembly units were ordered from Westinghouse. Virginia Power contracted Bechtel Power Corporation to provide the engineering and construction support to repair the Unit 1 steam generators. On January 4, 1993, after an extended coastdown period, North Anna Unit 1 was brought off-line and the 110 day (breaker-to-breaker) Steam Generator Replacement Project (SGRP) outage began. As of this paper, the outage is still in progress

Dr. Anna G. Jonasdottir: Acceptance Speech for Honorary Doctorate from Faculty of Political Science, University of Iceland. Given 18th of June, 2015

OpenAIRE

Anna G. Jónasdóttir

2016-01-01

On June 18th the Faculty of Political Science, University of Iceland, celebrated 100 years of women’s‘ voting rights in Iceland with a special conference, Power and democracy 100 years later. In association with the conference Dr. Anna Guðrún Jónasdóttir, Professor emerita at the University of Örebro, Sweden, was awarded an honorary doctorate at the Faculty of Political Science. Anna Guðrún was the first Icelandic woman to complete a doctorate in political science, in 1991, and also the first...

The "Matchbox School" (1927-1932): Anna Freud and the Idea of a "Psychoanalytically Informed Education"

Science.gov (United States)

Midgley, Nick

2008-01-01

Of all the applications of psychoanalysis to various fields, perhaps none has been as important--or as fraught--as the application of psychoanalytic insights to education. This paper re-constructs some of the early debates around psychoanalysis and pedagogy that Anna Freud engaged with during the 1920s in Vienna, when the whole question of what…

Predictive value of K-ras and PIK3CA in non-small cell lung cancer patients treated with EGFR-TKIs: a systemic review and meta-analysis

International Nuclear Information System (INIS)

Chen, Jie-Ying; Cheng, Ya-Nan; Han, Lei; Wei, Feng; Yu, Wen-Wen; Zhang, Xin-Wei; Cao, Shui; Yu, Jin-Pu

2015-01-01

A meta-analysis was performed to augment the insufficient data on the impact of mutative EGFR downstream phosphatidylinositol-3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways on the clinical efficiency of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) treatment of non-small cell lung cancer (NSCLC) patients. Network databases were explored in April, 2015. Papers that investigated the clinical outcomes of NSCLC patients treated with EGFR-TKIs according to the status of K-ras and/or PIK3CA gene mutation were included. A quantitative meta-analysis was conducted using standard statistical methods. Odds ratios (ORs) for objective response rate (ORR) and hazard ratios (HRs) for progression-free survival (PFS) and overall survival (OS) were calculated. Mutation in K-ras significantly predicted poor ORR [OR =0.22; 95% confidence interval (CI), 0.13-0.35], shorter PFS (HR =1.56; 95% CI, 1.27-1.92), and shorter OS (HR =1.59; 95% CI, 1.33-1.91) in NSCLC patients treated with EGFR-TKIs. Mutant PIK3CA significantly predicted shorter OS (HR =1.83; 95% CI, 1.05-3.20), showed poor ORR (OR =0.70; 95% CI, 0.22-2.18), and shorter PFS (HR =1.79; 95% CI, 0.91-3.53) in NSCLC patients treated with EGFR-TKIs. K-ras mutation adversely affected the clinical response and survival of NSCLC patients treated with EGFR-TKIs. PIK3CA mutation showed similar trends. In addition to EGFR, adding K-ras and PIK3CA as routine gene biomarkers in clinical genetic analysis is valuable to optimize the effectiveness of EGFR-TKI regimens and identify optimal patients who will benefit from EGFR-TKI treatment

PIK3CA-associated developmental disorders exhibit distinct classes of mutations with variable expression and tissue distribution

OpenAIRE

Mirzaa, Ghayda; Timms, Andrew E.; Conti, Valerio; Boyle, Evan August; Girisha, Katta M.; Martin, Beth; Kircher, Martin; Olds, Carissa; Juusola, Jane; Collins, Sarah; Park, Kaylee; Carter, Melissa; Glass, Ian; Kr?geloh-Mann, Inge; Chitayat, David

2016-01-01

Mosaicism is increasingly recognized as a cause of developmental disorders with the advent of next-generation sequencing (NGS). Mosaic mutations of PIK3CA have been associated with the widest spectrum of phenotypes associated with overgrowth and vascular malformations. We performed targeted NGS using 2 independent deep-coverage methods that utilize molecular inversion probes and amplicon sequencing in a cohort of 241 samples from 181 individuals with brain and/or body overgrowth. We identifie...

Analisis Simbolik Kyrie Eleison Karya Anna Wahyu Prasetyowati

Directory of Open Access Journals (Sweden)

RINA MARTIARA

2013-11-01

Full Text Available Symbolic Analysis of Kyrie Eleison of Anna Wahyu Prasetyowati’s Work. This paper describes and interpretsthe Kyrie Eleison as a performing arts. Kyrie Eleison text is read through choreography elements that shape thethemes, motion, musical accompaniment, fashion makeup, fl oor pattern, form and stage layout. This paper useshermeneutic approach. Based on the research it can be concluded that this work has a deep meaning. The story ofJesus Christ journey in teaching the word with great passion until his death on the Cross is fi xated religious valuesthat serve as an example for mankind. This work also contains the values of humanity that every human being mustbe having a miserable, suffering, and death. Humans must be steadfast and strong in the face of every temptationthat comes when he/she want to achieve the highest inner awareness and understanding of divine truth.

Costos y rendimientos de producción de tres néctares de manzana (pyrusmalusl variedades Anna, Pensilvania y Winter

Directory of Open Access Journals (Sweden)

Darío Alberto Pinto Medina

2016-12-01

Full Text Available La agroindustria en Colombia se muestra como una alternativa para dar aprovechamiento eficiente a materias primas de origen agropecuario, especialmente aquellas que por parámetros de calidad, no salen al mercado y generan cuantiosas pérdidas a agricultores y ganaderos; esta investigación se basó principalmente en el aprovechamiento de la manzana (Pyrus malus L, se elaboró néctar con tres variedades producidas en el departamento de Boyacá, Colombia: Pensilvania, Anna y Winter y se evaluaron los rendimientos en extracción de pulpa, con pérdidas del 18,4% para Pensilvania 21,4%, para Anna y 30%en Winter. Se realizaron pruebas sensoriales para determinar el grado de aceptabilidad de los tres productos, observándose diferencias significativas en textura, y similitud en parámetros como olor, color y sabor; para dicho análisis se compararon las tres variedades con un néctar comercial. Se concluye que el costo de producción unitario para 900 ml de néctar de la variedad Pensilvania es de $4.999, Anna $5.100 y Winter $5.296 (pesos colombianos, esto se debe a mejores rendimientos en extracción de pulpa para la variedad Pensilvania, mostrando que los productos son competitivos en precio y calidad.

Mida teeb Narva kutseõppekeskus teie arvates Narva linna heaks? / Burkina, Irina; Patlep, Kaarel; Kaalik, Ljubov; Dolgovskaja, Tatjana; Ibragimov, Muret; Vorobjova, Anna

Index Scriptorium Estoniae

2007-01-01

Vastavad Narva Kutseõppekeskuse kutseõpetajad Irina Burkina, Tatjana Dolgovskaja ja Murat Ibragimov ning autovaldkonna juht Kaarel Patlep, projektijuht Ljubov Kaalik ja PR-spetsialist Anna Vorobjova

Produção de conhecimento na enfermagem em oncologia: contribuição da escola de enfermagem Anna Nery Producción de conocimiento en la enfermería en oncología: contribución de la escola de enfermagem anna nery (escuela de enfermería Anna Nery Production of knowledge in nursing in oncology: contribution of Anna Nery nursing school

Directory of Open Access Journals (Sweden)

Marléa Chagas Moreira

2010-09-01

Full Text Available O estudo teve como objetivos mapear as teses e dissertações produzidas no Programa de Pós-Graduação da Escola de Enfermagem Anna Nery com enfoque na enfermagem em oncologia e analisar as repercussões diante dos aspectos epistemológicos destacados. Estudo exploratório, descritivo, retrospectivo e bibliográfico de 59 estudos (45 dissertações e 14 teses produzidos de 1980 a 2009. O referencial teórico-metodológico foi a Metodologia de Categorização Epistemológica para a Pesquisa na Enfermagem. Os resultados indicam que a produção analisada é mais setorizada na área da oncologia clínica, com ênfase nos aspectos Gestão Saúde/Enfermagem, Saúde da Mulher e Fundamentos do Cuidado de Enfermagem. Houve predomínio de estudos na perspectiva sociológica com abordagem qualitativa. As repercussões demonstradas nos aspectos epistemológicos destacados possibilitam afirmar que o conhecimento produzido é consistente com a complexidade e as tentativas de explicação sobre a arte de cuidar dos clientes com câncer e com esforços de definir/ampliar critérios e padrões assistenciais. Enfermagem Oncológica. Pesquisa em Enfermagem. Educação de Pós-graduação em EnfermagemEl estudio tuvo como objetivo mapear las tesis y disertaciones del Programa de Posgraduado de la Escola de Enfermagem Anna Nery (Escuela de Enfermería Anna Nery con énfasis en la enfermería en oncología y analizar las repercusiones frente los aspectos epistemológicos señalados. Exploratorio, descriptivo, retrospectivo y documental de 59 estudios (45 disertaciones y 14 tesis producidos desde 1980 hasta 2009. El referencial teórico-metodológico fue la Metodología Epistemológica para la Investigación en Enfermería. Los resultados indican que la producción es la más sectorizada de la oncología clínica, con énfasis en Gestión de la Salud / Enfermería, Salud de la Mujer y Fundamentos de la Atención de Enfermería. Se detectó un predominio de los

Molecular spectrum of KRAS, NRAS, BRAF, PIK3CA, TP53, and APC somatic gene mutations in Arab patients with colorectal cancer: determination of frequency and distribution pattern

Science.gov (United States)

Al-Shamsi, Humaid O.; Jones, Jeremy; Fahmawi, Yazan; Dahbour, Ibrahim; Tabash, Aziz; Abdel-Wahab, Reham; Abousamra, Ahmed O. S.; Shaw, Kenna R.; Xiao, Lianchun; Hassan, Manal M.; Kipp, Benjamin R.; Kopetz, Scott; Soliman, Amr S.; McWilliams, Robert R.; Wolff, Robert A.

2016-01-01

Background The frequency rates of mutations such as KRAS, NRAS, BRAF, and PIK3CA in colorectal cancer (CRC) differ among populations. The aim of this study was to assess mutation frequencies in the Arab population and determine their correlations with certain clinicopathological features. Methods Arab patients from the Arab Gulf region and a population of age- and sex-matched Western patients with CRC whose tumors were evaluated with next-generation sequencing (NGS) were identified and retrospectively reviewed. The mutation rates of KRAS, NRAS, BRAF, PIK3CA, TP53, and APC were recorded, along with clinicopathological features. Other somatic mutation and their rates were also identified. Fisher’s exact test was used to determine the association between mutation status and clinical features. Results A total of 198 cases were identified; 99 Arab patients and 99 Western patients. Fifty-two point seven percent of Arab patients had stage IV disease at initial presentation, 74.2% had left-sided tumors. Eighty-nine point two percent had tubular adenocarcinoma and 10.8% had mucinous adenocarcinoma. The prevalence rates of KRAS, NRAS, BRAF, PIK3CA, TP53, APC, SMAD, FBXW7 mutations in Arab population were 44.4%, 4%, 4%, 13.1%, 52.5%, 27.3%, 2% and 3% respectively. Compared to 48.4%, 4%, 4%, 12.1%, 47.5%, 24.2%, 11.1% and 0% respectively in matched Western population. Associations between these mutations and patient clinicopathological features were not statistically significant. Conclusions This is the first study to report comprehensive hotspot mutations using NGS in Arab patients with CRC. The frequency of KRAS, NRAS, BRAF, TP53, APC and PIK3CA mutations were similar to reported frequencies in Western population except SMAD4 that had a lower frequency and higher frequency of FBXW7 mutation. PMID:28078112

Associations between primary tumor RAS, BRAF and PIK3CA mutation status and metastatic site in patients with chemo-resistant metastatic colorectal cancer

DEFF Research Database (Denmark)

Christensen, Troels Dreier; Palshof, Jesper Andreas; Larsen, Finn Ole

2018-01-01

investigated the association between RAS (KRAS or NRAS), BRAF, PIK3CA mutations and metastatic pattern in patients with metastatic (m) CRC. MATERIAL AND METHODS: This study reviewed Danish biobank and database of patients with mCRC who received cetuximab and irinotecan, independent of RAS mutation status...

Study On In Vitro Variation Generation Of Cymbidium Labell Anna Belle By Gamma Co-60 Irradiation

International Nuclear Information System (INIS)

Nguyen Huynh Phuong Uyen; Vo Thi Thu Ha; Le Quang Luan

2011-01-01

Radiation ionization is one of useful methods for mutation breeding of plants. In this study, γ-ray (Co-60) was used for generating morphological variations of Cymbidium Labell Anna Belle. The lethal doses of 50% samples (LD 50 ) after 4 months cultivation were determined at 35.0 Gy for protocorm like bodies (PLBs), 37.4 Gy for in vitro shoot bubs and 70.1 Gy for plantlets. PLBs were found as suitable samples for generation of variation of mentioned Cymbidium. The dose range from 20 to 50 Gy was determined with a high ability of variation on C. Labell Anna Belle. The highest frequency of variation was obtained ca. 3.82 x 10 -3 at the dose of 30 Gy. 157 in vitro variant plantlets were selected in M 1 V 1 generation, among variations, the variations were mainly found with 5 following types: removal of chlorophyll (8 plantlets), the leaves become shorter (64 plantlets), the leaves become longer (64 plantlets), increase of leaf number (11 plantlets) and the colour of pericardium was changed from green into violet (10 plantlets). Twenty one variant lines were selected in M 1 V 2 generation. (author)

Patronage in the dispute over child analysis between Melanie Klein and Anna Freud--1927-1932.

Science.gov (United States)

Aguayo, J

2000-08-01

The author investigates the role of patrons and advocates for Melanie Klein's clinical ideas at the British Psycho-Analytical Society against the backdrop of her theoretical and technical differences with Anna Freud from 1927 to 1932. He also outlines the development of Klein and Anna Freud's theories and techniques within the nascent discipline of child psychoanalysis. The London and Viennese patrons/advocates contributed to polarising what initially were clinical differences about how to analyse pre-latency and latency-age children and which technical processes might best facilitate successful treatment. While the author speculates that a diversity of motivations and agendas may have driven the London group's support for Klein--personal and politicised enthusiasm (Jones), genuine conviction (Riviere) and attempts at theoretical rapprochement between the London and Vienna schools (Glover)--he also argues that Freud's diagnosis with cancer in 1923 and suspicion of patricidal son-successors necessitated the choice of a female successor with unquestioning loyalty to his doctrines. From 1932, when Klein's clinical authority was established, her first group of English supporters began to splinter, as she went on to become a training analyst, mentor and patron in her own right to a succeeding generation of adherents who defended her views during the Controversial Discussions.

Education and Access to Christian Thought in the Writing of Harriet Beecher Stowe and Anna Julia Cooper

Science.gov (United States)

Magno, JoJo

2009-01-01

In attempting to climb past the racist and sexist barriers which existed in nineteenth-century America, women could look to writers such as Harriet Beecher Stowe and Anna Julia Cooper. Their works not only reflect the conditions of women and African-American women in particular, but also call for access to educational opportunities for these women…

Dr. Anna G. Jonasdottir: Acceptance Speech for Honorary Doctorate from Faculty of Political Science, University of Iceland. Given 18th of June, 2015

Directory of Open Access Journals (Sweden)

Anna G. Jónasdóttir

2016-06-01

Full Text Available On June 18th the Faculty of Political Science, University of Iceland, celebrated 100 years of women’s‘ voting rights in Iceland with a special conference, Power and democracy 100 years later. In association with the conference Dr. Anna Guðrún Jónasdóttir, Professor emerita at the University of Örebro, Sweden, was awarded an honorary doctorate at the Faculty of Political Science. Anna Guðrún was the first Icelandic woman to complete a doctorate in political science, in 1991, and also the first to embark on an advanced academic career in political science and gender studies. It is therefore highly appropriate that Anna Guðrún should be awarded the first honorary doctorate at the Faculty of Political Science, where these disciplines are located. Her research covers a broad spectrum, including political science, sociology, economic history, psychology and gender studies. She was among the first to deal in a theoretical manner with gender, power and politics, which was considered rather provocative at the start of her academic career in the early 1970s. She is a pioneer in intertwining political research and gender studies and her most important research is in the field of power and personal gender relations. Anna Guðrún moved to Sweden at an early age but has kept in touch with the Icelandic research community. Below we publish her acceptance speech on the occasion when the honorary doctorate was awarded. It reflects clearly how her ideas have developed and her intimate sense for how personal and political factors bring politics and gender studies closer at the same time as she deepens and broadens both of their subjects.

["Signs for the whole rest of the life". The house as symbol and autobiographical substrate in letters, dreams and literary texts by by Anna Freud].

Science.gov (United States)

Spreitzer, Brigitte

2015-01-01

The house as object and symbol preoccupied Anna Freud from childhood onwards. This article traces these ideas in letters, autobiographical documents and literary texts. It focuses on the phantasmal construction of a dream house; on the organisation, loss and later efforts to recover Hochrotherd; on casual birthday poems dedicated to Anna, praising the country house, as well as on the purchase of a weekend cottage in Walberswick reflected in dreams related to the process of inner detachment from the dead father. A fluent interchange between reality and imagination comes into focus, high- lighting the dimension of inwardness rather than that of biographical reality.

Review Essay: John Pratt and Anna Eriksson (2013 'Contrasts in Punishment: An Explanation of Anglophone Excess and Nordic Exceptionalism'

Directory of Open Access Journals (Sweden)

David Brown

2013-11-01

Full Text Available This review essay combines the comments made by David Brown, Russell Hogg and Mark Finanne at the Crime, Justice and Social Democracy: 2nd International Conference July 2013. It is followed by a rejoinder by the two authors John Pratt and Anna Eriksson.

Die Zitruskultur am Hofe Ferdinands I. und Anna Jagiellos. Import und Anbau von Südfrüchten in Prag 1526–1564

Czech Academy of Sciences Publication Activity Database

Dobalová, Sylva; Hausenblasová, J.

-, č. 15 (2015), s. 9-36 ISSN 1213-5372 Institutional support: RVO:68378033 Keywords : Ferdinand I * Anna of Jagiello * orange fruit * renaissance gardens * trade * residence Subject RIV: AL - Art, Architecture, Cultural Heritage

PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation

OpenAIRE

Anderson, Grace R.; Wardell, Suzanne E.; Cakir, Merve; Crawford, Lorin; Leeds, Jim C.; Nussbaum, Daniel P.; Shankar, Pallavi S.; Soderquist, Ryan S.; Stein, Elizabeth M.; Tingley, Jennifer P.; Winter, Peter S.; Zieser-Misenheimer, Elizabeth K.; Alley, Holly M.; Yllanes, Alexander; Haney, Victoria

2016-01-01

Therapies that efficiently induce apoptosis are likely to be required for durable clinical responses in patients with solid tumors. Using a pharmacological screening approach, we discovered that the combined inhibition of BCL-XL and the mTOR/4E-BP axis results in selective and synergistic induction of apoptosis in cellular and animal models of PIK3CA mutant breast cancers, including triple negative tumors. Mechanistically, inhibition of mTOR/4E-BP suppresses MCL-1 protein translation only in ...

Promoter Variant of PIK3C3 Is Associated with Autoimmunity against Ro and Sm Epitopes in African-American Lupus Patients

Directory of Open Access Journals (Sweden)

Silvia N. Kariuki

2010-01-01

Full Text Available The PIK3C3 locus was implicated in case-case genome-wide association study of systemic lupus erythematosus (SLE which we had performed to detect genes associated with autoantibodies and serum interferon-alpha (IFN-α. Herein, we examine a PIK3C3 promoter variant (rs3813065/-442 C/T in an independent multiancestral cohort of 478 SLE cases and 522 controls. rs3813065 C was strongly associated with the simultaneous presence of both anti-Ro and anti-Sm antibodies in African-American patients [OR=2.24 (1.34–3.73, P=2.0×10−3]. This autoantibody profile was associated with higher serum IFN-α (P=7.6×10−6. In the HapMap Yoruba population, rs3813065 was associated with differential expression of ERAP2 (P=2.0×10−5, which encodes an enzyme involved in MHC class I peptide processing. Thus, rs3813065 C is associated with a particular autoantibody profile and altered expression of an MHC peptide processing enzyme, suggesting that this variant modulates serologic autoimmunity in African-American SLE patients.

Restart Testing Program for piping following steam generator replacement at North Anna Unit 1

International Nuclear Information System (INIS)

Bain, R.A.; Bayer, R.K.

1993-01-01

In order to provide assurance that the effects of performing steam generator replacement (SGR) at North Anna unit 1 had no adverse impact on plant piping systems, a cold functional verification restart testing program was developed. This restart testing program was implemented in lieu of a hot functional testing program normally used during the initial startup of a nuclear plant. A review of North Anna plant-specific and generic U.S. Nuclear Regulatory Commission requirements for restart testing was performed to ensure that no mandatory hot functional testing was required. This was determined to be the case, and the development of a cold functional test program was initiated. The cold functional test had inherent advantages as compared to the hot functional testing, while still providing assurance of piping system adequacy. The advantages of the cold verification program included reducing risk to personnel from hot piping, increasing the accuracy of measurements with the improvement in work conditions, eliminating engineering activities during the heatup process, and being able to record measurements as construction work was completed allowing for rework or repair of components if required. To ensure the effectiveness of the cold verification program, a project procedure was generated to identify the personnel, equipment, and measurement requirements. An engineering calculation was issued to document the scope of the restart test program, and an additional calculation was developed to provide acceptance criteria for the critical commodity measurements

THE FEMALE’S MASCULINITIES AGAINST SIAMESE PATRIARCHAL SYSTEMS IN ELIZABETH HAND’S ANNA AND THE KING

Directory of Open Access Journals (Sweden)

Anna Sriastuti

2017-04-01

Full Text Available By not giving voice and value to women‘s opinions, responses and writings, men have therefore suppressed the female, define what it means to be feminine, and therefore devoiced, devalued, and trivialized what it means to be a woman. As femininity is mostly related to women for women are labeled as extensions of men, mirrors of men, devices for showing men off, and also devices for helping men get what they want, women‘s position is inferior to men. This study discusses the female‘s masculinities through the portrayal and life experiences of the main female characteristics, Anna Leonowens, as her protests against the Siamese patriarchal systems that abundant her life as a career woman and also the oppressed lives of Siamese women in Elizabeth Hand‘s novel Anna and the King. Feminism and Deconstructions approaches will be applied to analyze Leonowens‘ actions and reactions regarding to what Siamese patriarchal systems claim to be parts of masculine traits. Leonowens‘ nationality, cultural and educational backgrounds as well as positions play significant roles in the novel. By opposing Leonowens‘ ways of thinking to the King who represents the patriarchal system of Siam, Hand gives a new identity to women in struggling for gender equality in Siam.

Analisando o conteúdo da seção "Página do Estudante" dos Annaes de Enfermagem Analisando el contenido de la sección "Pagina del Estudiante" de los Annaes de Enfermagem Analysing the content of the section Students' page of the Annaes de Enfermagem

Directory of Open Access Journals (Sweden)

Marlene Nunes Morais Pereira

2006-01-01

Full Text Available A Revista Annaes Enfermagem foi um veiculo para retratar os problemas da saúde e evidenciar o exercício da profissão. A seção página do estudante foi criada para dar incentivo ao aluno, para expor suas idéias e focar pontos importantes na formação do enfermeiro da época. Este trabalho teve por objetivo analisar e descrever o conteúdo das publicações no período de 1932 a 1941. Trata-se de estudo de abordagem qualitativa pelo método histórico. Os principais elementos descritos na seção analisada estavam relacionados com os problemas de saúde, como escarlatina, tétano eclâmpsia. Conclui-se que o conteúdo do material analisado reflete que neste período existia uma preocupação com a preparação das alunas para suprir a necessidade vigente que o país atravessava.El periodico Annaes de Enfermagem ha sido el veiculo para discutir los problemas de salud y para evidenciar el professional rol. La sección "Pagina de estudiante" há sido creada para incentivar los estudiantes a exponer sus ideas y para focalisar en los puntos relevantes de formación del enfermero el aquelle tienpo . Esto estúdio objectivó describir y analisar el contenido de lo material publicado em el periodo de 1932 hasta 1941. Esto és um estudio con abordaje cualitativo usandoce el metodo historìco. Los principales elementos descriptos en la sección analisada estan relacionados a los problemas de salud colectiva como la escarlatina, tétano, eclampsia y tanbien a la ética. Se ha concluydo que el contenido del material analisado reflete que en el período analisado habia una preocupación com la preparación del studiante para atender a las necesidades de salud que el pais presentava.The journal Annaes de Enfermagem was a publishing vehicle to discuss health problems and to evidence the professional role. The section "Students Page" Was created for the motivation of students to expose their ideas and to focus in relevant points of the nurse education by

Parallel Federal/State Antitrust Investigations

OpenAIRE

Stephen Houck

2012-01-01

Those matters in which both federal and state antitrust authorities do take an interest usually have significant impacts across state lines and even international borders. Stephen D. Houck (Menaker & Herrmann LLP)

Zwei Briefromane eines gewitzten böhmischen Frauenzimmers im Reprint: Maria Anna Sagers Beiträge zur frühen Frauenliteratur

Czech Academy of Sciences Publication Activity Database

Wögerbauer, Michael

2015-01-01

Roč. 39, č. 2 (2015), s. 240-243. ISBN 978-3-8353-16-97-3. ISSN 0722-740X Institutional support: RVO:68378068 Keywords : enlightenment * prose * Sager, Maria Anna * female writer * German literature * Czech literature Subject RIV: AJ - Letters, Mass-media, Audiovision

Physiatrie and German maternal feminism: Dr. Anna Fischer-Dückelmann critiques academic medicine.

Science.gov (United States)

Meyer, Paulette

2006-01-01

Alternative medicine and reform strategies made Anna Fischer-Dückelmann a most controversial, notorious, and widely read women doctor before World War I. She published a dozen titles in 13 languages asserting that national well-being depended on maternal prowess. To her critics, Fischer-Dückelmann's commitment to medical self-help and practices of Physiatrie amounted to medical quackery. Her career has been largely unexamined, yet her feminist critiques and social concerns are not far removed from modern social medicine. For this pioneering doctor, treating physical and emotional ills and promoting the health of families were first steps toward healing the divisions of a world at war.

Effective lifetime measurements in the $B_{s}^{0} \\rightarrow K^{+}K^{-}$, $B^{0} \\rightarrow K^{+}\\pi^{-}$ and $B_{s}^{0} \\rightarrow \\pi^{+}K^{-}$ decays

CERN Document Server

INSPIRE-00258707; Adeva, B.; Adinolfi, M.; Affolder, A.; Ajaltouni, Z.; Albrecht, J.; Alessio, F.; Alexander, M.; Ali, S.; Alkhazov, G.; Alvarez Cartelle, P.; Alves Jr, A.A.; Amato, S.; Amerio, S.; Amhis, Y.; An, L.; Anderlini, L.; Anderson, J.; Andreassen, R.; Andreotti, M.; Andrews, J.E.; Appleby, R.B.; Aquines Gutierrez, O.; Archilli, F.; Artamonov, A.; Artuso, M.; Aslanides, E.; Auriemma, G.; Baalouch, M.; Bachmann, S.; Back, J.J.; Badalov, A.; Balagura, V.; Baldini, W.; Barlow, R.J.; Barschel, C.; Barsuk, S.; Barter, W.; Batozskaya, V.; Bauer, Th.; Bay, A.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Belogurov, S.; Belous, K.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S.; Benton, J.; Berezhnoy, A.; Bernet, R.; Bettler, M.O.; van Beuzekom, M.; Bien, A.; Bifani, S.; Bird, T.; Bizzeti, A.; Bjornstad, P.M.; Blake, T.; Blanc, F.; Blouw, J.; Blusk, S.; Bocci, V.; Bondar, A.; Bondar, N.; Bonivento, W.; Borghi, S.; Borgia, A.; Borsato, M.; Bowcock, T.J.V.; Bowen, E.; Bozzi, C.; Brambach, T.; van den Brand, J.; Bressieux, J.; Brett, D.; Britsch, M.; Britton, T.; Brook, N.H.; Brown, H.; Bursche, A.; Busetto, G.; Buytaert, J.; Cadeddu, S.; Calabrese, R.; Calvi, M.; Calvo Gomez, M.; Camboni, A.; Campana, P.; Campora Perez, D.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carranza-Mejia, H.; Carson, L.; Carvalho Akiba, K.; Casse, G.; Cassina, L.; Garcia, L.Castillo; Cattaneo, M.; Cauet, Ch.; Cenci, R.; Charles, M.; Charpentier, Ph.; Cheung, S.F.; Chiapolini, N.; Chrzaszcz, M.; Ciba, K.; Cid Vidal, X.; Ciezarek, G.; Clarke, P.E.L.; Clemencic, M.; Cliff, H.V.; Closier, J.; Coco, V.; Cogan, J.; Cogneras, E.; Collins, P.; Comerma-Montells, A.; Contu, A.; Cook, A.; Coombes, M.; Coquereau, S.; Corti, G.; Corvo, M.; Counts, I.; Couturier, B.; Cowan, G.A.; Craik, D.C.; Cruz Torres, M.; Cunliffe, S.; Currie, R.; D'Ambrosio, C.; Dalseno, J.; David, P.; David, P.N.Y.; Davis, A.; De Bruyn, K.; De Capua, S.; De Cian, M.; de Miranda, J.M.; De Paula, L.; De Silva, W.; De Simone, P.; Decamp, D.; Deckenhoff, M.; Del Buono, L.; Deleage, N.; Derkach, D.; Deschamps, O.; Dettori, F.; Di Canto, A.; Dijkstra, H.; Donleavy, S.; Dordei, F.; Dorigo, M.; Dosil Suarez, A.; Dossett, D.; Dovbnya, A.; Dupertuis, F.; Durante, P.; Dzhelyadin, R.; Dziurda, A.; Dzyuba, A.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; El Rifai, I.; Elsasser, Ch.; Esen, S.; Evans, T.; Falabella, A.; Farber, C.; Farinelli, C.; Farley, N.; Farry, S.; Ferguson, D.; Fernandez Albor, V.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fiore, M.; Fiorini, M.; Firlej, M.; Fitzpatrick, C.; Fiutowski, T.; Fontana, M.; Fontanelli, F.; Forty, R.; Francisco, O.; Frank, M.; Frei, C.; Frosini, M.; Fu, J.; Furfaro, E.; Gallas Torreira, A.; Galli, D.; Gallorini, S.; Gambetta, S.; Gandelman, M.; Gandini, P.; Gao, Y.; Garofoli, J.; Garra Tico, J.; Garrido, L.; Gaspar, C.; Gauld, R.; Gavardi, L.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Gianelle, A.; Giani', S.; Gibson, V.; Giubega, L.; Gligorov, V.V.; Gobel, C.; Golubkov, D.; Golutvin, A.; Gomes, A.; Gordon, H.; Gotti, C.; Grabalosa Gandara, M.; Graciani Diaz, R.; Granado Cardoso, L.A.; Grauges, E.; Graziani, G.; Grecu, A.; Greening, E.; Gregson, S.; Griffith, P.; Grillo, L.; Grunberg, O.; Gui, B.; Gushchin, E.; Guz, Yu.; Gys, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Haines, S.C.; Hall, S.; Hamilton, B.; Hampson, T.; Han, X.; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S.T.; Harrison, J.; Hartmann, T.; He, J.; Head, T.; Heijne, V.; Hennessy, K.; Henrard, P.; Henry, L.; Hernando Morata, J.A.; van Herwijnen, E.; Hess, M.; Hicheur, A.; Hill, D.; Hoballah, M.; Hombach, C.; Hulsbergen, W.; Hunt, P.; Hussain, N.; Hutchcroft, D.; Hynds, D.; Idzik, M.; Ilten, P.; Jacobsson, R.; Jaeger, A.; Jalocha, J.; Jans, E.; Jaton, P.; Jawahery, A.; Jezabek, M.; Jing, F.; John, M.; Johnson, D.; Jones, C.R.; Joram, C.; Jost, B.; Jurik, N.; Kaballo, M.; Kandybei, S.; Kanso, W.; Karacson, M.; Karbach, T.M.; Kelsey, M.; Kenyon, I.R.; Ketel, T.; Khanji, B.; Khurewathanakul, C.; Klaver, S.; Kochebina, O.; Kolpin, M.; Komarov, I.; Koopman, R.F.; Koppenburg, P.; Korolev, M.; Kozlinskiy, A.; Kravchuk, L.; Kreplin, K.; Kreps, M.; Krocker, G.; Krokovny, P.; Kruse, F.; Kucharczyk, M.; Kudryavtsev, V.; Kurek, K.; Kvaratskheliya, T.; La Thi, V.N.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lambert, D.; Lambert, R.W.; Lanciotti, E.; Lanfranchi, G.; Langenbruch, C.; Langhans, B.; Latham, T.; Lazzeroni, C.; Le Gac, R.; van Leerdam, J.; Lees, J.P.; Lefevre, R.; Leflat, A.; Lefrancois, J.; Leo, S.; Leroy, O.; Lesiak, T.; Leverington, B.; Li, Y.; Liles, M.; Lindner, R.; Linn, C.; Lionetto, F.; Liu, B.; Liu, G.; Lohn, S.; Longstaff, I.; Lopes, J.H.; Lopez-March, N.; Lowdon, P.; Lu, H.; Lucchesi, D.; Luo, H.; Lupato, A.; Luppi, E.; Lupton, O.; Machefert, F.; Machikhiliyan, I.V.; Maciuc, F.; Maev, O.; Malde, S.; Manca, G.; Mancinelli, G.; Manzali, M.; Maratas, J.; Marchand, J.F.; Marconi, U.; Benito, C.Marin; Marino, P.; Marki, R.; Marks, J.; Martellotti, G.; Martens, A.; Martin Sanchez, A.; Martinelli, M.; Martinez Santos, D.; Martinez Vidal, F.; Martins Tostes, D.; Massafferri, A.; Matev, R.; Mathe, Z.; Matteuzzi, C.; Mazurov, A.; McCann, M.; McCarthy, J.; McNab, A.; McNulty, R.; McSkelly, B.; Meadows, B.; Meier, F.; Meissner, M.; Merk, M.; Milanes, D.A.; Minard, M.N.; Moggi, N.; Molina Rodriguez, J.; Monteil, S.; Moran, D.; Morandin, M.; Morawski, P.; Morda, A.; Morello, M.J.; Moron, J.; Mountain, R.; Muheim, F.; Muller, K.; Muresan, R.; Mussini, M.; Muster, B.; Naik, P.; Nakada, T.; Nandakumar, R.; Nasteva, I.; Needham, M.; Neri, N.; Neubert, S.; Neufeld, N.; Neuner, M.; Nguyen, A.D.; Nguyen, T.D.; Nguyen-Mau, C.; Nicol, M.; Niess, V.; Niet, R.; Nikitin, N.; Nikodem, T.; Novoselov, A.; Oblakowska-Mucha, A.; Obraztsov, V.; Oggero, S.; Ogilvy, S.; Okhrimenko, O.; Oldeman, R.; Onderwater, G.; Orlandea, M.; Otalora Goicochea, J.M.; Owen, P.; Oyanguren, A.; Pal, B.K.; Palano, A.; Palombo, F.; Palutan, M.; Panman, J.; Papanestis, A.; Pappagallo, M.; Parkes, C.; Parkinson, C.J.; Passaleva, G.; Patel, G.D.; Patel, M.; Patrignani, C.; Pazos Alvarez, A.; Pearce, A.; Pellegrino, A.; Pepe Altarelli, M.; Perazzini, S.; Perez Trigo, E.; Perret, P.; Perrin-Terrin, M.; Pescatore, L.; Pesen, E.; Petridis, K.; Petrolini, A.; Picatoste Olloqui, E.; Pietrzyk, B.; Pilar, T.; Pinci, D.; Pistone, A.; Playfer, S.; Plo Casasus, M.; Polci, F.; Poluektov, A.; Polycarpo, E.; Popov, A.; Popov, D.; Popovici, B.; Potterat, C.; Powell, A.; Prisciandaro, J.; Pritchard, A.; Prouve, C.; Pugatch, V.; Puig Navarro, A.; Punzi, G.; Qian, W.; Rachwal, B.; Rademacker, J.H.; Rakotomiaramanana, B.; Rama, M.; Rangel, M.S.; Raniuk, I.; Rauschmayr, N.; Raven, G.; Reichert, S.; Reid, M.M.; dos Reis, A.C.; Ricciardi, S.; Richards, A.; Rihl, M.; Rinnert, K.; Rives Molina, V.; Roa Romero, D.A.; Robbe, P.; Rodrigues, A.B.; Rodrigues, E.; Rodriguez Perez, P.; Roiser, S.; Romanovsky, V.; Vidal, A.Romero; Rotondo, M.; Rouvinet, J.; Ruf, T.; Ruffini, F.; Ruiz, H.; Valls, P.Ruiz; Sabatino, G.; Saborido Silva, J.J.; Sagidova, N.; Sail, P.; Saitta, B.; Salustino Guimaraes, V.; Sanchez Mayordomo, C.; Sanmartin Sedes, B.; Santacesaria, R.; Santamarina Rios, C.; Santovetti, E.; Sapunov, M.; Sarti, A.; Satriano, C.; Satta, A.; Savrie, M.; Savrina, D.; Schiller, M.; Schindler, H.; Schlupp, M.; Schmelling, M.; Schmidt, B.; Schneider, O.; Schopper, A.; Schune, M.H.; Schwemmer, R.; Sciascia, B.; Sciubba, A.; Seco, M.; Semennikov, A.; Senderowska, K.; Sepp, I.; Serra, N.; Serrano, J.; Sestini, L.; Seyfert, P.; Shapkin, M.; Shapoval, I.; Shcheglov, Y.; Shears, T.; Shekhtman, L.; Shevchenko, V.; Shires, A.; Coutinho, R.Silva; Simi, G.; Sirendi, M.; Skidmore, N.; Skwarnicki, T.; Smith, N.A.; Smith, E.; Smith, E.; Smith, J.; Smith, M.; Snoek, H.; Sokoloff, M.D.; Soler, F.J.P.; Soomro, F.; Souza, D.; Souza De Paula, B.; Spaan, B.; Sparkes, A.; Spinella, F.; Spradlin, P.; Stagni, F.; Stahl, S.; Steinkamp, O.; Stenyakin, O.; Stevenson, S.; Stoica, S.; Stone, S.; Storaci, B.; Stracka, S.; Straticiuc, M.; Straumann, U.; Stroili, R.; Subbiah, V.K.; Sun, L.; Sutcliffe, W.; Swientek, K.; Swientek, S.; Syropoulos, V.; Szczekowski, M.; Szczypka, P.; Szilard, D.; Szumlak, T.; T'Jampens, S.; Teklishyn, M.; Tellarini, G.; Teubert, F.; Thomas, C.; Thomas, E.; van Tilburg, J.; Tisserand, V.; Tobin, M.; Tolk, S.; Tomassetti, L.; Tonelli, D.; Topp-Joergensen, S.; Torr, N.; Tournefier, E.; Tourneur, S.; Tran, M.T.; Tresch, M.; Tsaregorodtsev, A.; Tsopelas, P.; Tuning, N.; Garcia, M.Ubeda; Ukleja, A.; Ustyuzhanin, A.; Uwer, U.; Vagnoni, V.; Valenti, G.; Vallier, A.; Vazquez Gomez, R.; Vazquez Regueiro, P.; Vazquez Sierra, C.; Vecchi, S.; Velthuis, J.J.; Veltri, M.; Veneziano, G.; Vesterinen, M.; Viaud, B.; Vieira, D.; Vieites Diaz, M.; Vilasis-Cardona, X.; Vollhardt, A.; Volyanskyy, D.; Voong, D.; Vorobyev, A.; Vorobyev, V.; Voss, C.; Voss, H.; de Vries, J.A.; Waldi, R.; Wallace, C.; Wallace, R.; Walsh, J.; Wandernoth, S.; Wang, J.; Ward, D.R.; Watson, N.K.; Websdale, D.; Whitehead, M.; Wicht, J.; Wiedner, D.; Wilkinson, G.; Williams, M.P.; Williams, M.; Wilson, F.F.; Wimberley, J.; Wishahi, J.; Wislicki, W.; Witek, M.; Wormser, G.; Wotton, S.A.; Wright, S.; Wu, S.; Wyllie, K.; Xie, Y.; Xing, Z.; Xu, Z.; Yang, Z.; Yuan, X.; Yushchenko, O.; Zangoli, M.; Zavertyaev, M.; Zhang, F.; Zhang, L.; Zhang, W.C.; Zhang, Y.; Zhelezov, A.; Zhokhov, A.; Zhong, L.; Zvyagin, A.

2014-01-01

Measurements of the effective lifetimes in the $B_{s}^{0} \\rightarrow K^{+}K^{-}$, $B^{0} \\rightarrow K^{+}\\pi^{-}$ and $B_{s}^{0} \\rightarrow \\pi^{+}K^{-}$ decays are presented using $1.0~\\mathrm{fb^{-1}}$ of $pp$ collision data collected at a centre-of-mass energy of 7 TeV by the LHCb experiment. The analysis uses a data-driven approach to correct for the decay time acceptance. The measured effective lifetimes are $\\tau_{B_{s}^{0} \\rightarrow K^{+}K^{-}}$ = $1.407~\\pm~0.016~\\pm~0.007~\\mathrm{ps}$, $\\tau_{B^{0} \\rightarrow K^{+}\\pi^{-}}$ = $1.524~\\pm~0.011~\\pm~0.004~\\mathrm{ps}$, $\\tau_{B_{s}^{0} \\rightarrow \\pi^{+}K^{-}}$ = $1.60~\\pm~0.06~\\pm~0.01~\\mathrm{ps}$. This is the most precise determination to date of the effective lifetime in the $B_{s}^{0} \\rightarrow K^{+}K^{-}$ decay and provides constraints on contributions from physics beyond the Standard Model to the $B_{s}^{0}$ mixing phase and the width difference $\\Delta\\Gamma_{s}$.

Astronaut Anna Fisher Suits Up for NBS Training

Science.gov (United States)

1980-01-01

The Hubble Space Telescope (HST) is a cooperative program of the European Space Agency (ESA) and the National Aeronautical and Space Administration (NASA) to operate a long-lived space-based observatory. It was the flagship mission of NASA's Great Observatories program. The HST program began as an astronomical dream in the 1940s. During the 1970s and 1980s, the HST was finally designed and built becoming operational in the 1990s. The HST was deployed into a low-Earth orbit on April 25, 1990 from the cargo bay of the Space Shuttle Discovery (STS-31). The design of the HST took into consideration its length of service and the necessity of repairs and equipment replacement by making the body modular. In doing so, subsequent shuttle missions could recover the HST, replace faulty or obsolete parts and be re-released. Marshall Space Flight Center's (MSFC's) Neutral Buoyancy Simulator (NBS) served as the test center for shuttle astronauts training for Hubble related missions. Shown is astronaut Anna Fisher suiting up for training on a mockup of a modular section of the HST for an axial scientific instrument change out.

Astronaut Anna Fisher Suiting Up For NBS Training

Science.gov (United States)

1980-01-01

The Hubble Space Telescope (HST) is a cooperative program of the European Space Agency (ESA) and the National Aeronautical and Space Administration (NASA) to operate a long-lived space-based observatory. It was the flagship mission of NASA's Great Observatories program. The HST program began as an astronomical dream in the 1940s. During the 1970s and 1980s, the HST was finally designed and built becoming operational in the 1990s. The HST was deployed into a low-Earth orbit on April 25, 1990 from the cargo bay of the Space Shuttle Discovery (STS-31). The design of the HST took into consideration its length of service and the necessity of repairs and equipment replacement by making the body modular. In doing so, subsequent shuttle missions could recover the HST, replace faulty or obsolete parts and be re-released. Marshall Space Flight Center's (MSFC's) Neutral Buoyancy Simulator (NBS) served as the test center for shuttle astronauts training for Hubble related missions. Shown is astronaut Anna Fisher suiting up for training on a mockup of a modular section of the HST for an axial scientific instrument change out.

Astronaut Anna Fisher Suited Up For NBS Training

Science.gov (United States)

1980-01-01

The Hubble Space Telescope (HST) is a cooperative program of the European Space Agency (ESA) and the National Aeronautical and Space Administration (NASA) to operate a long-lived space-based observatory. It was the flagship mission of NASA's Great Observatories program. The HST program began as an astronomical dream in the 1940s. During the 1970s and 1980s, the HST was finally designed and built becoming operational in the 1990s. The HST was deployed into a low-Earth orbit on April 25, 1990 from the cargo bay of the Space Shuttle Discovery (STS-31). The design of the HST took into consideration its length of service and the necessity of repairs and equipment replacement by making the body modular. In doing so, subsequent shuttle missions could recover the HST, replace faulty or obsolete parts and be re-released. Marshall Space Flight Center's (MSFC's) Neutral Buoyancy Simulator (NBS) served as the test center for shuttle astronauts training for Hubble related missions. Shown is astronaut Anna Fisher suited up for training on a mockup of a modular section of the HST for an axial scientific instrument change out.

Seismic design margin evaluation of systems and equipment required for safe shutdown of North Anna, Units 1 and 2, following an SSE (safe-shutdown earthquake) event. Technical report

International Nuclear Information System (INIS)

Desai, K.D.

1981-06-01

The Advisory Committee on Reactor Safeguards recommended that the NRC staff review in detail the capability and available seismic design margin of fluid systems and equipment used in North Anna, Units 1 and 2 to achieve safe shutdown following a site-design safe-shutdown earthquake (SSE). The staff conducted a series of plant visits and meetings with the licensee to view and discuss the seismic design methodology used for systems, equipment and their supports. The report is a description and evaluation of the seismic design criteria, design conservatisms and seismic design margin for North Anna, Units 1 and 2

Anna-Caterina Walk: Das Andere im Tatort. Migration und Integration im Fernsehkrimi. Marburg: Tectum Wissenschaftsverlag 2011.

Directory of Open Access Journals (Sweden)

Patricia Piberger

2012-08-01

Full Text Available Aus medien- und kulturwissenschaftlicher Perspektive widmet sich Anna-Caterina Walk in ihrer knappen Publikation der TV-Krimireihe ‚Tatort‘. Anhand von drei konkreten Folgen analysiert sie, wie das Andere in dieser Serie medial repräsentiert und konstruiert wird. Ihr Ziel ist es, die konkreten Darstellungen und deren Bedeutungen in ihrer Selbstverständlichkeit zu hinterfragen. Dabei sucht sie vor allem nach nicht-stereotypen oder destabilisierenden Bildern und fordert zugleich einen kritischeren Umgang mit Differenzkonstruktionen der Identität innerhalb der einzelnen ‚Tatort‘-Folgen. Zumal der Fokus der Autorin auf kulturellen Andersartigkeiten liegt, kommen Betrachtungen des_der geschlechtlich Anderen eine marginale Position zu und bleiben prinzipiell eher oberflächlich.In her concise publication, Anna-Caterina Walk dedicates herself to the TV crime series Tatort using a media studies and cultural studies perspective. Based on three specific episodes, she analyzes how the ‘other’ is medially represented and constructed in the series. She aims at questioning the self-evidence of specific representations and their meanings. In doing so, she searches, above all, for non-stereotypical or destabilizing images and, at the same time, demands a more critical approach to constructions of difference regarding identity within the individual Tatort episodes. Considerations of the gendered ‘other/s’ are treated only marginally and generally remain superficial, particularly since the author focuses on cultural otherness.

Program for studying fundamental interactions at the PIK reactor facilities

International Nuclear Information System (INIS)

Serebrov, A. P.; Vassiljev, A. V.; Varlamov, V. E.; Geltenbort, P.; Gridnev, K. A.; Dmitriev, S. P.; Dovator, N. A.; Egorov, A. I.; Ezhov, V. F.; Zherebtsov, O. M.; Zinoviev, V. G.; Ivochkin, V. G.; Ivanov, S. N.; Ivanov, S. A.; Kolomensky, E. A.; Konoplev, K. A.; Krasnoschekova, I. A.; Lasakov, M. S.; Lyamkin, V. A.; Martemyanov, V. P.

2016-01-01

A research program aimed at studying fundamental interactions by means of ultracold and polarized cold neutrons at the GEK-4-4′ channel of the PIK reactor is presented. The apparatus to be used includes a source of cold neutrons in the heavy-water reflector of the reactor, a source of ultracold neutrons based on superfluid helium and installed in a cold-neutron beam extracted from the GEK-4 channel, and a number of experimental facilities in neutron beams. An experiment devoted to searches for the neutron electric dipole moment and an experiment aimed at a measurement the neutron lifetime with the aid of a large gravitational trap are planned to be performed in a beam of ultracold neutrons. An experiment devoted to measuring neutron-decay asymmetries with the aid of a superconducting solenoid is planned in a beam of cold polarized neutrons from the GEK-4′ channel. The second ultracold-neutron source and an experiment aimed at measuring the neutron lifetime with the aid of a magnetic trap are planned in the neutron-guide system of the GEK-3 channel. In the realms of neutrino physics, an experiment intended for sterile-neutrino searches is designed. The state of affairs around the preparation of the experimental equipment for this program is discussed.

Program for studying fundamental interactions at the PIK reactor facilities

Energy Technology Data Exchange (ETDEWEB)

Serebrov, A. P., E-mail: serebrov@pnpi.spb.ru; Vassiljev, A. V.; Varlamov, V. E. [National Research Center Kurchatov Institute, Petersburg Nuclear Physics Institute (Russian Federation); Geltenbort, P. [Institut Laue-Langevin (France); Gridnev, K. A. [St. Petersburg State University (Russian Federation); Dmitriev, S. P.; Dovator, N. A. [Russian Academy of Sciences, Ioffe Physical-Technical Institute (Russian Federation); Egorov, A. I.; Ezhov, V. F.; Zherebtsov, O. M.; Zinoviev, V. G.; Ivochkin, V. G.; Ivanov, S. N.; Ivanov, S. A.; Kolomensky, E. A.; Konoplev, K. A.; Krasnoschekova, I. A.; Lasakov, M. S.; Lyamkin, V. A. [National Research Center Kurchatov Institute, Petersburg Nuclear Physics Institute (Russian Federation); Martemyanov, V. P. [National Research Center Kurchatov Institute (Russian Federation); and others

2016-05-15

A research program aimed at studying fundamental interactions by means of ultracold and polarized cold neutrons at the GEK-4-4′ channel of the PIK reactor is presented. The apparatus to be used includes a source of cold neutrons in the heavy-water reflector of the reactor, a source of ultracold neutrons based on superfluid helium and installed in a cold-neutron beam extracted from the GEK-4 channel, and a number of experimental facilities in neutron beams. An experiment devoted to searches for the neutron electric dipole moment and an experiment aimed at a measurement the neutron lifetime with the aid of a large gravitational trap are planned to be performed in a beam of ultracold neutrons. An experiment devoted to measuring neutron-decay asymmetries with the aid of a superconducting solenoid is planned in a beam of cold polarized neutrons from the GEK-4′ channel. The second ultracold-neutron source and an experiment aimed at measuring the neutron lifetime with the aid of a magnetic trap are planned in the neutron-guide system of the GEK-3 channel. In the realms of neutrino physics, an experiment intended for sterile-neutrino searches is designed. The state of affairs around the preparation of the experimental equipment for this program is discussed.

[Questions and worries. On the correspondence of Grete Bibring and Anna Freud 1949-1975].

Science.gov (United States)

Bakman, Nina

2015-01-01

Grete Bibring (1899 - 1977) was a representative of the second generation of analysts. Having emigrated from Vienna to London in 1938, she left for Boston in 1942 where she made a remarkable career. 1946 she became head of the department of psychiatry at the Beth-Israel hospital in Harvard and from 1961 the first woman professor of medicine there. She maintained a connection with European psychoanalysis in the person of Anna Freud with whom she corresponded regularly. Their letters contain an interesting exchange of ideas about psychoanalytic institutions (e.g. the American Psychoanalytical Association) and papers (e.g. on pregnancy). It is also the testimony of an exceptional friendship.

Studi Komunikasi Interpersonal Antara Perawat Dengan Lansia Di Panti Lansia Santa Anna Teluk Gong Jakarta

Directory of Open Access Journals (Sweden)

Mela Cristanty

2016-12-01

Full Text Available This study discusses the interpersonal communication between the nurses with elderly who were living in a nursing home. Establishment of a nursing home is one of the government's efforts to address the issue of social welfare for the elderly. Like the other nursing homes Nursing Home “Santa Anna” also have nurses on duty to take care the elderly living at home. In order to perform their duties the nurses need to perform an effective interpersonal communication with the elderly. Interpersonal communication activities have influence in building a relationship with the elderly in order to provide guidance, supervision and encouragement to the elderly. The theory used in this research is theory of communication, interpersonal communication, social penetration theory, concept of nurses, the elderly and nursing homes. This study used descriptive qualitative method and authors conducted in-depth interviews with four informants, namely two nurses and two elderly people, also made observation and doing literature study. The results of this study reveals that the closeness of interpersonal relations between nurses and elderly in Nursing Home “Santa Anna” can be seen through five general quality that are openness, positive behavior, supportive behavior, empathy, and equality. These five factors mentioned above is run entirely by nurses in the Nursing Home “Santa Anna” in terms of communicating and forming relationships with the elderly who live in institutions. Penelitian ini membahas mengenai komunikasi antarpribadi yang dilakukan antara perawat dengan lansia yang tinggal di panti jompo. Pendirian panti jompo merupakan salah satu usaha pemerintah dalam menangani masalah kesejahteraan sosial untuk para lansia. Seperti panti-panti jompo lainnya Panti Lansia Santa Anna juga memiliki perawat-perawat yang bertugas untuk merawat, mengurus, dan mengasuh para lansia yang tinggal di panti. Untuk dapat menjalankan tugas serta perannya perawat perlu

Investigating the structure and dynamics of the PIK3CA wild-type and H1047R oncogenic mutant.

Directory of Open Access Journals (Sweden)

Paraskevi Gkeka

2014-10-01

Full Text Available The PIK3CA gene is one of the most frequently mutated oncogenes in human cancers. It encodes p110α, the catalytic subunit of phosphatidylinositol 3-kinase alpha (PI3Kα, which activates signaling cascades leading to cell proliferation, survival, and cell growth. The most frequent mutation in PIK3CA is H1047R, which results in enzymatic overactivation. Understanding how the H1047R mutation causes the enhanced activity of the protein in atomic detail is central to developing mutant-specific therapeutics for cancer. To this end, Surface Plasmon Resonance (SPR experiments and Molecular Dynamics (MD simulations were carried out for both wild-type (WT and H1047R mutant proteins. An expanded positive charge distribution on the membrane binding regions of the mutant with respect to the WT protein is observed through MD simulations, which justifies the increased ability of the mutated protein variant to bind to membranes rich in anionic lipids in our SPR experiments. Our results further support an auto-inhibitory role of the C-terminal tail in the WT protein, which is abolished in the mutant protein due to loss of crucial intermolecular interactions. Moreover, Functional Mode Analysis reveals that the H1047R mutation alters the twisting motion of the N-lobe of the kinase domain with respect to the C-lobe and shifts the position of the conserved P-loop residues in the vicinity of the active site. These findings demonstrate the dynamical and structural differences of the two proteins in atomic detail and propose a mechanism of overactivation for the mutant protein. The results may be further utilized for the design of mutant-specific PI3Kα inhibitors that exploit the altered mutant conformation.

Non-destructive and destructive examination of the retired North Anna 2 Reactor Pressure Vessel Head

International Nuclear Information System (INIS)

Ahluwalia, Kawaljit; Barnes, Robert; Rao, Gutti; Cattant, Francois; Peat, Noel

2006-09-01

Stress corrosion cracking of Alloy 600 and nickel-based weld materials has been the single biggest challenge facing the PWR industry. A fundamental and thorough knowledge was needed to properly explain this phenomenon and develop appropriate mitigation strategies. Non Destructive Examination (NDE) of the North Anna Unit 2 Reactor Vessel Head (RVH) during the 2002 fall outage identified widespread crack indications in the Alloy 600 CRDM penetrations and associated Alloy 182 and 82 J-groove attachment welds. When the Utility decided to replace the RVH, a rare opportunity was provided to the industry to undertake in-depth studies of representative defective CRDM penetrations from a retired RVH. Accordingly, the Materials Reliability Program, undertook a two-phase program on the retired North Anna 2 Alloy 600 RVH. The first phase involved selection and removal of six penetrations from the RVH and penetration decontamination, replication and laboratory NDE. The second phase consisted of a detailed destructive examination of penetration number 54. This paper provides a summary of work undertaken during this program. Criteria for selection of penetrations for removal and procedures used in removal of the penetrations are described. Extreme care was undertaken in decontamination of the penetrations to facilitate laboratory NDE. Penetration number 54 was then subjected to destructive examination to establish a correlation between NDE findings (from both field and laboratory inspections) and actual flaws. Additional objectives of the destructive examination included mechanistic assessment of defect formation and investigation of the annulus environment and wastage characterization. Data obtained from these studies is invaluable in validating safety assessment statements by developing the correlation between field NDE and actual defects. In addition, information gathered from non-destructive and destructive examinations is used to assess accuracy of the NDE techniques

Hollandse zee- en scheepstermen in het Russisch: Anna Croiset van der Kop versus Reinder van der Meulen

Directory of Open Access Journals (Sweden)

Nadja Louwerse

2010-03-01

Full Text Available Dutch nautical terms in Russian. Anna Croiset van der Kop versus Reinder van der Meulen This article explores the controversy in the beginning of the 20th century between de Dutch slavists Anna Croiset van der Kop and Reindert van der Meulen, author of the book De Hollandsche Zee- en Scheepstermen in het Russisch (Dutch Nautical Terms in Russian. After publication, she reacted with an undeniably negative and unusually elaborate review (72 pages!, written not in Dutch, but in Russian and published in one of the most leading, scientific series in Russia. Van der Meulen has never directly reacted to this review: in 1959 he published a supplement to his earlier work from 1909: Nederlandse woorden in het Russisch (Dutch words in Russian, not mentioning Croiset van der Kops name, nor her review. Obviously he felt hurt by her merciless criticism. The article focuses on the motives underlying her strong reaction. It will be argued that her severe criticism was not really inspired by Van der Meulen’s subject, but by his failing research methods. Furthermore, it will be pointed out that this review seemed to offer her an opportunity to measure up to her Dutch colleagues and to present herself internationally as a slavist. On the basis of the now available data it is hard to say, which motives really brought Croiset van der Kop to write her review. Investigation of her archives, preserved in St- Petersburg, and until now hardly studied, may perhaps reveal her real motives.

Astronaut Anna Fisher in NBS Training For Hubble Space Telescope

Science.gov (United States)

1980-01-01

The Hubble Space Telescope (HST) is a cooperative program of the European Space Agency (ESA) and the National Aeronautical and Space Administration (NASA) to operate a long-lived space-based observatory. It was the flagship mission of NASA's Great Observatories program. The HST program began as an astronomical dream in the 1940s. During the 1970s and 1980s, the HST was finally designed and built becoming operational in the 1990s. The HST was deployed into a low-Earth orbit on April 25, 1990 from the cargo bay of the Space Shuttle Discovery (STS-31). The design of the HST took into consideration its length of service and the necessity of repairs and equipment replacement by making the body modular. In doing so, subsequent shuttle missions could recover the HST, replace faulty or obsolete parts and be re-released. Marshall Space Flight Center's (MSFC's) Neutral Buoyancy Simulator (NBS) served as the test center for shuttle astronauts training for Hubble related missions. Shown is astronaut Anna Fisher training on a mock-up of a modular section of the HST for an axial scientific instrument change out.

Solid radwaste characterization at surry and North Anna Power Stations

International Nuclear Information System (INIS)

Lippard, D.W.

1987-01-01

This paper describes a characterization of the solid radwaste generated at Virginia Power's North Anna and Surry power stations. The primary focus of this characterization was dry active waste (DAW). The characterization, covering the 21-month period from January 1985 through September 1986, was based on information in the station's health physics procurement records, radwaste shipping records, and from interviews with station personnel. The procurement records were the principal source of information for DAW. They were reviewed to determine the quantities of various materials, purchased during the study period, that were expected to become DAW. This provides an upper limit on the quantity in the waste for several major DAW components and a basis for the total amount of other components in the waste. The approach to characterizing DAW discussed in this paper could be implemented and regularly updated by utilizing a computerized procurement records system. If a use code (i.e., contaminated or noncontaminated) is associated with each stock requisition, a characterization could be performed by a computer run. This approach would help track minimization effort effectiveness and would refine the characterization of DAW considerably

Rec.: Anna Niepytalska-Osiecka, Socjolekt polskich alpinistów. Analiza leksykalno-semantyczna słownictwa, Wydawnictwo LIBRON – Filip Lohner, Kraków 2014, ss. 286

Directory of Open Access Journals (Sweden)

Beata Jarosz

2017-12-01

Full Text Available Review: Anna Niepytalska-Osiecka, Socjolekt polskich alpinistów. Analiza leksykalnosemantyczna słownictwa, Wydawnictwo LIBRON – Filip Lohner, Kraków 2014, 286 pp. The article is a review of Anna Niepytalska-Osiecka’s book Socjolekt polskich alpinistów. Analiza leksykalno-semantyczna słownictwa (The sociolect of Polish mountaineers. A lexical and semantic analysis of the vocabulary. First, the text summarizes the subject matter of this monograph, devoted to a hitherto undescribed variety of the Polish language. It then goes on to characterize the composition of the book and its methodology. Finally, some problematic points are indicated – concerning, among other things, the classification of the language variety analyzed or the development of its vocabulary – and alternative lexical and semantic solutions are suggested.   Rec.: Anna Niepytalska-Osiecka, Socjolekt polskich alpinistów. Analiza leksykalno-semantyczna słownictwa, Wydawnictwo LIBRON – Filip Lohner, Kraków 2014, ss. 286 Artykuł stanowi recenzję książki Anny Niepytalskiej-Osieckiej pt. Socjolekt polskich alpinistów. Analiza leksykalno-semantyczna słownictwa. W tekście przybliżono zawartą w monografii problematykę poświęconą nieopisanemu dotychczas wariantowi polszczyzny oraz scharakteryzowano zastosowane rozwiązania kompozycyjne i analityczne. Wskazano również punkty dyskusyjne dotyczące m.in. klasyfikacji opisywanego wariantu polszczyzny czy procesu kształtowania się jego zasobu słownego, a także zasugerowano alternatywne rozstrzygnięcia leksykalno-semantyczne.

Two Austro-Hungarian Women Writers, Anna Tutsek and Terka Lux, Creating New Urban Identities in Early Twentieth-Century Budapest

OpenAIRE

Judit Kádár

2016-01-01

In this paper, I examine some literary texts of two turn-of-the century Hungarian women writers, Anna Tutsek and Terka Lux who left behind their childhood environment in remote regions of the Austro-Hungarian Monarchy in order to move to Budapest, the capital of the eastern part of the Empire. Assuming that individuals hold multiple identities that are flexible and inevitably affected by environmental and social changes, my main focus is on the transformation of their ethnic, regional, occupa...

Translating Anna Karenina - to the Question About the Pragmatics of Translation

Directory of Open Access Journals (Sweden)

Ekaterina Gurina

2016-09-01

Full Text Available The article deals with the stylistic peculiarities of the translations made by R. Pevear and L. Volokhonsky, L. and A. Maud, J. Carmichael of the novel Anna Karenina by L. Tolstoy on the basis of pragmastylistics and comparative analysis. It tries to analyze the text of the novel using the lingo-stylistic characteristics in accordance with the national bias in the way of thinking and individual creative preferences of every translator taking an attempt to introduce a foreign picture of the world to his countrymen. It underlines the impact of Tolstoy’s complicated attitude towards the customs and traditions of the Russian Orthodox church and the specific relationship of the author of the novel with God and its manifestation in the description of the heroes’ characters. In stresses how vital it may turn out to preserve the author’s ideostyle - lexis and syntax (the word order, the choice of them and the length of the sentences for the successful interpretation of the writer’s views and stance by the reader.

Antitumor Efficacy of the Dual PI3K/mTOR Inhibitor PF-04691502 in a Human Xenograft Tumor Model Derived from Colorectal Cancer Stem Cells Harboring a PIK3CA Mutation.

Directory of Open Access Journals (Sweden)

Douglas D Fang

Full Text Available PIK3CA (phosphoinositide-3-kinase, catalytic, alpha polypeptide mutations can help predict the antitumor activity of phosphatidylinositol-3-kinase (PI3K/mammalian target of rapamycin (mTOR pathway inhibitors in both preclinical and clinical settings. In light of the recent discovery of tumor-initiating cancer stem cells (CSCs in various tumor types, we developed an in vitro CSC model from xenograft tumors established in mice from a colorectal cancer patient tumor in which the CD133+/EpCAM+ population represented tumor-initiating cells. CD133+/EpCAM+ CSCs were enriched under stem cell culture conditions and formed 3-dimensional tumor spheroids. Tumor spheroid cells exhibited CSC properties, including the capability for differentiation and self-renewal, higher tumorigenic potential and chemo-resistance. Genetic analysis using an OncoCarta™ panel revealed a PIK3CA (H1047R mutation in these cells. Using a dual PI3K/mTOR inhibitor, PF-04691502, we then showed that blockage of the PI3K/mTOR pathway inhibited the in vitro proliferation of CSCs and in vivo xenograft tumor growth with manageable toxicity. Tumor growth inhibition in mice was accompanied by a significant reduction of phosphorylated Akt (pAKT (S473, a well-established surrogate biomarker of PI3K/mTOR signaling pathway inhibition. Collectively, our data suggest that PF-04691502 exhibits potent anticancer activity in colorectal cancer by targeting both PIK3CA (H1047R mutant CSCs and their derivatives. These results may assist in the clinical development of PF-04691502 for the treatment of a subpopulation of colorectal cancer patients with poor outcomes.

Anna Freud and the Holocaust: mourning and survival guilt.

Science.gov (United States)

Hartman, John J

2014-12-01

This article explores the period of Anna Freud's life after she was informed of the deaths of her aunts in Nazi concentration camps during World War II. Understanding of this period may be enhanced by consideration of the role of the Holocaust in her complicated mourning process. A series of her dreams is re-examined from the point of view of survivor guilt and the complicated mourning of her father in the context of the Holocaust. It is argued that unconscious reproaches against her father led to an identification with him that included his 'decision' to leave his sisters in Vienna. Survivor guilt in relation to her aunts' murders is seen as one of the complicating factors in the mourning process. In addition the article discusses the possible role of this period, particularly her work with child concentration camp survivors, in her post-war writing. The noted duality in her work between innovation and conservatism is explored in terms of an outcome of the mourning process of this period. It is argued that her views on mourning, trauma, attachment, and the widening scope of indications for psychoanalysis were influenced by the outcome of her mourning process. Finally, an irony is noted in the fact that her attitude about altruism never changed despite the role of the altruism of others in her rescue from the Nazis. Copyright © 2014 Institute of Psychoanalysis.

Burst muscle performance predicts the speed, acceleration, and turning performance of Anna's hummingbirds.

Science.gov (United States)

Segre, Paolo S; Dakin, Roslyn; Zordan, Victor B; Dickinson, Michael H; Straw, Andrew D; Altshuler, Douglas L

2015-11-19

Despite recent advances in the study of animal flight, the biomechanical determinants of maneuverability are poorly understood. It is thought that maneuverability may be influenced by intrinsic body mass and wing morphology, and by physiological muscle capacity, but this hypothesis has not yet been evaluated because it requires tracking a large number of free flight maneuvers from known individuals. We used an automated tracking system to record flight sequences from 20 Anna's hummingbirds flying solo and in competition in a large chamber. We found that burst muscle capacity predicted most performance metrics. Hummingbirds with higher burst capacity flew with faster velocities, accelerations, and rotations, and they used more demanding complex turns. In contrast, body mass did not predict variation in maneuvering performance, and wing morphology predicted only the use of arcing turns and high centripetal accelerations. Collectively, our results indicate that burst muscle capacity is a key predictor of maneuverability.

Elementos do Projeto Político Profissional da Associação Nacional das Enfermeiras Diplomadas Brasileiras presentes nos Annaes de Enfermagem Elementos del Proyecto Politico Profesional de la Asociación Nacional de Enfermeras Graduadas Brasileras presentes en los Annaes de Enfermagem Elements of the Political Professional Project of the Brazilian Graduate Nurses National Association present in the Annaes de Enfermagem

Directory of Open Access Journals (Sweden)

Jane Liliane Gonçalves da Cruz

2006-01-01

Full Text Available A revista Annaes de Enfermagem foi criada para publicar idéias, conceitos, resultados da produção científica, reflexões e, principalmente, o de expor e discutir o Projeto Político Profissional da Associação Nacional de Enfermeiras Diplomadas Brasileiras (ANEDB. Este estudo teve como objetivo descrever e caracterizar estes elementos presentes na referida revista no período de 1932 a 1941. Trata-se de um estudo de abordagem qualitativa pelo método histórico. Os principais elementos do projeto político compreendem os atributos desejáveis no enfermeiro como altruísmo, abnegação, patriotismo, senso humanitário, progresso profissional ligado à educação, arte, ideal, ética e componentes da religião cristã. Todos estes elementos fizeram parte de um projeto político que visava a integração da enfermagem no contexto de saúde nacional da época. (118 palavras.El periódico Annaes de Enfermagem fue creado para publicar ideas, conceptos, resultados de la producción cientifica, reflexiones y principalmente o de presentar y discutir el proyecto politico profesional de la Asociación Nacional de Enfermeras Graduadas Brasileras. Este estudio tuvo como objectivo decribir y caracterizar estos elementos presentes en este periódico en lo periodo de 1932 hasta 1941. Tratase de um estudio de abordaje cualitativa por lo metodo historico. Lo principales elementos del proyecto politico compreenden los atributos desejables en lo enfermero como el altruismo, abnegación, patriotismo, senso humaño, progreso profesional junto com la educación, arte, ideal, etica y componentes de la religión cristiana. Todos los elementos hicierón parte del proyecto politico que objectivó la integración de la enfermería en el contexto de salud en ámbito nacional a la epoca.The journal Annaes de Enfermagem was created to publish ideas, concepts, results of scientific production, reflections and, meanly to expose the Political Professional Project of the

Escritor-personagem e leitor cúmplice em Sérgio Sant'anna

Directory of Open Access Journals (Sweden)

Igor Ximenes Graciano

2012-11-01

Full Text Available As narrativas de Sérgio Sant’Anna sugerem, pela exposição recorrente dos bastidores da criação literária (aqui entendida como gesto literário, que o discurso ficcional extrapola o espaço da literatura, repercutindo as relações dos indivíduos no “mundo real”. Em sua prosa é evidente a tentativa dos narradores de aproximarem o leitor para suas perspectivas, quando a narrativa assemelha-se a um jogo em que o prêmio é a cumplicidade deste a quem ela se dirige. Com isso, estende-se uma via de mão-dupla entre vida e imaginário, de modo que uma constitui e é constituída pelo outro. Como afirma Carlos Santeiro, personagem de Um romance de geração, trata-se das “possibilidades possíveis” do texto para além do texto, uma vez que o acordo entre narrador romanesco e leitor – e que sustenta o acontecimento literário – carrega muito dos pressupostos das diversas instâncias discursivas entre indivíduos, ficcionais ou não.

Costos y rendimientos de producción de tres néctares de manzana (pyrusmalusl) variedades Anna, Pensilvania y Winter

OpenAIRE

Darío Alberto Pinto Medina; Yesenia Fernández Vargas; Efrain Martinez Quintero

2016-01-01

La agroindustria en Colombia se muestra como una alternativa para dar aprovechamiento eficiente a materias primas de origen agropecuario, especialmente aquellas que por parámetros de calidad, no salen al mercado y generan cuantiosas pérdidas a agricultores y ganaderos; esta investigación se basó principalmente en el aprovechamiento de la manzana (Pyrus malus L), se elaboró néctar con tres variedades producidas en el departamento de Boyacá, Colombia: Pensilvania, Anna y Winter y se evaluaron l...

Claiming justice: knowing mental illness in the public art of Anna Schuleit's 'Habeas Corpus' and 'Bloom'.

Science.gov (United States)

Bell, Susan E

2011-05-01

This study investigates two public art performances by artist Anna Schuleit in the early 2000s commemorating the life and history of two state hospitals ('asylums') in Massachusetts and the people who built, worked, and were patients in them. Public art is made for and sited in the public domain, outside, freely accessible, frequently collaborative, and often ephemeral. This study addresses a series of questions: What can public art 'do' for understanding mental illness? What use is a public art project for those living with (and caring for those who live with) mental illness? How can a public work of art sustain and portray meaning in an expressive way, open up a shared discursive space, and demand witness through embodiment?

Mito e realtà della letteratura ebraica al femminile in Germania: Anna Seghers e Mascha Kaléko

Directory of Open Access Journals (Sweden)

Karin Birge Gilardoni-Büch

2014-04-01

Both of them succeed in emigrating and surviving the destruction of the European Jews. Anna Seghers comes back in 1947 to the Soviet occupied zone and will later hold significant offices inside East Germany's cultural life. Mascha Kaléko will however come back only now and then to the German Federal Republic. Did their writing change after the Shoah? And if so, to what extent? Moreover, do the texts mirror the situation in which their authors found themselves? Aren’t they linked to a specific social condition, that of a woman? To what extent do specific female and Jewish experiences take shape in their works?

Measurement of glacier velocity at Pik Lenin, Tajikistan, by feature tracking

Science.gov (United States)

Kumari, S.; Ghosh, S. K.; Buchroithner, M. F.

2014-11-01

Glaciers, especially in mountain area are sensitive indicators of climate fluctuations and also contribute to present rates of sea level rise. In Central Asia, these glaciers are the primary resource for fresh water. Understanding the seasonal behavior of these glaciers would help to make efficient use of the available water reservoir. Different methods have been employed to study glacier displacements in past. The conventional survey techniques are very cost-intensive and highly depend on accessibility to high mountain glaciers also directs us to look for new ways to study these areas. Here remote sensing comes in handy with freely available data and a good coverage with high spatial and temporal resolution. Optical satellite imagery, available free can be effectively used for research purpose. The glacier in this region fed lake Karakul (380 km2), the largest Lake in Tajikistan. The objective is to study the displacement tendency of the Glacier in Pik Lenin area using Landsat 7 dataset. Normalized cross correlation algorithm has been implemented via CIAS to estimate the motion of glacier surface. A number of combination of reference block and search area size were tested for 30 m resolution dataset. As a result the specifications: reference block size of 15 pixels and search area size of 10 pixels was found out as the best set of parameters and considered for further processing. The study derives a reliable set of data depicting the velocities in the glacier which after post processing shows peak velocity of 121 m/y of the glacier.

Biblioteca escolar das escolas reunidas Sant’anna do Paranahyba/MT (1936-1945: contribuições para o estudo de sua história.

Directory of Open Access Journals (Sweden)

Rosimar Pires Alves

2016-12-01

Full Text Available Neste texto apresentam-se os resultados de pesquisa de mestrado vinculada ao Programa de Pós-Graduação em Educação da Universidade Estadual de Mato Grosso do Sul (UEMS, Unidade Universitária de Paranaíba, sobre o tema história das bibliotecas escolares na escola primária urbana em Paranaíba/MT. A pesquisa é oriunda dos resultados do projeto “Memória da Escola Primária em Paranaíba/MS (1946-1971”, desenvolvido no âmbito do Grupo de Estudos e Pesquisas em História e Historiografia da Educação Brasileira (GEPHEB. No projeto verificou-se em alguns documentos escolares localizados, reunidos e selecionados sobre as Escolas Reunidas Sant‟Anna do Paranahyba – um dos primeiros núcleos de escolarização do município de Paranaíba –, a fundação e a organização de uma biblioteca escolar a partir do ano de 1936, o que levou à constituição do objeto de estudo. Com isso traçou-se como objetivo contribuir para a produção de uma história das bibliotecas escolares em Mato Grosso do Sul e no Brasil, a partir da história da primeira biblioteca escolar organizada nas Escolas Reunidas Sant‟Anna do Paranahyba, mediante localização, reunião, seleção, organização e análise de fontes documentais sobre a implantação, o acervo, as especificidades e os sujeitos envolvidos. O recorte temporal abrange o período de 1936 – início das atividades da biblioteca escolar – até 1945, quando as Escolas Reunidas Sant‟Anna do Paranahyba foram transformadas no Grupo Escolar José Garcia Leal. A pesquisa fundamentou-se na abordagem histórica, no campo da educação, na vertente da Nova História que apresenta um leque de possibilidades no que se refere à pesquisa histórica em educação, constituindo um campo produtivo de estudos. Assim, a pesquisa realizada permitiu compreender que a Biblioteca Escolar das Escolas Reunidas Sant‟Anna do Paranahyba não se mostrou aquém do movimento em prol da leitura e das bibliotecas

Impact of KRAS, BRAF, PIK3CA mutations, PTEN, AREG, EREG expression and skin rash in ≥ 2 line cetuximab-based therapy of colorectal cancer patients.

Directory of Open Access Journals (Sweden)

Zacharenia Saridaki

2011-01-01

Full Text Available To investigate the predictive significance of KRAS, BRAF, PIK3CA mutational status, AREG- EREG mRNA expression, PTEN protein expression and skin rash in metastatic colorectal cancer (mCRC patients treated with cetuximab containing salvage chemotherapy.Primary tumors from 112 mCRC patients were analyzed. The worst skin toxicity during treatment was recorded.KRAS, BRAF and PIK3CA mutations were present in 37 (33%, 8 (7.2% and 11 (9.8% cases, respectively, PTEN was lost in 21 (19.8% cases, AREG and EREG were overexpressed in 48 (45% and 51 (49% cases. In the whole study population, time to tumor progression (TTP and overall survival (OS was significantly lower in patients with KRAS (p = 0.001 and p = 0.026, respectively or BRAF (p = 0.001 and p<0.0001, respectively mutant tumors, downregulation of AREG (p = 0.018 and p = 0.013, respectively or EREG (p = 0.002 and p = 0.004, respectively and grade 0-1 skin rash (p<0.0001 and p<0.0001, respectively. In KRAS wt patients TTP and OS was significantly lower in patients with BRAF (p = 0.0001 and p<0.0001, respectively mutant tumors, downregulation of AREG (p = 0.021 and p = 0.004, respectively or EREG (p = 0.0001 and p<0.0001, respectively and grade 0-1 skin rash (p<0.0001 and p<0.0001, respectively. TTP was significantly lower in patients with PIK3CA mutations (p = 0.01 or lost PTEN (p = 0.002. Multivariate analysis revealed KRAS (Hazard Ratio [HR] 4.3, p<0.0001, BRAF mutation (HR: 5.1, p<0.0001, EREG low expression (HR: 1.6, p = 0.021 and absence of severe/moderate skin rash (HR: 4.0, p<0.0001 as independent prognostic factors for decreased TTP. Similarly, KRAS (HR 2.9, p = 0.01, BRAF mutation (HR: 3.0, p = 0.001, EREG low expression (HR: 1.7, p = 0.021, absence of severe/moderate skin rash (HR: 3.7, p<0.0001 and the presence of undifferantited tumours (HR: 2.2, p = 0.001 were revealed as independent prognostic factors for decreased OS.These results underscore that KRAS-BRAF mutations and EREG

Qarṭaŷanna y Bāguh, cecas almohades, y la hipótesis de las

Directory of Open Access Journals (Sweden)

Vega Martín, Miguel

2006-06-01

Full Text Available

A huge hoard of Almohad (Muwaḥḥid coins was found in Priego de Cordoba (Cordoba, Spain in 1959. It contains several thousands of silver coins and is kept in the Archeological and Ethnological Museum of Cordoba. The hoard provides archeological evidences that Qarṭaŷanna and Bāguh, so far unregistered in Almohad coins, must be added to the list of Andalusi mints of that period. After identifying the two names of towns as Cartagena (Murcia, Spain and Priego de Cordoba, the hypothesis that the Almohad authorities issued series of coins as commemoration of relevant political or religious events is maintained.

En el Museo Arqueológico y Etnológico de Córdoba se conserva un copioso tesorillo de monedas almohades de plata compuesto por varios millares de piezas, hallado en Priego de Córdoba en 1959. Algunas de ellas permiten la lectura de dos nuevas cecas: las de Qarṭaŷanna y Bāguh, que pueden identificarse con las localidades españolas actuales de Cartagena y Priego. La multiplicidad de cecas almohades recibe aquí una explicación hipotética: se trataría de acuñaciones conmemorativas de acontecimientos políticos o religiosos.

Tematy, których nie da się uśpić. Z Jerzym Jedlickim rozmawia Anna Zawadzka

Directory of Open Access Journals (Sweden)

Anna Zawadzka

2012-12-01

Full Text Available On subjects that cannot be put to sleep. Anna Zawadzka in an interview with Jerzy Jedlicki The conversation with Jerzy Jedlicki is a part of series of interviews starting with the question about the subjects, that the interlocutors during his or her academical career were advised (by different persons and for different reasons not to pursue. Jedlicki mentions about three such issues: Poles and Jews during II World War period, Israel and Palestine, atheism and faith. He points out that nobody discouraged him from pursuing these subjects – it was himself, who refrained from being vocal on these matters. He clarifies why he used to censor himself, analyses how all the subjects work today in Polish public sphere and explains why he broke the silence several times.   Tematy, których nie da się uśpić. Z Jerzym Jedlickim rozmawia Anna Zawadzka Rozmowa z Jerzym Jedlickim przynależy do cyklu wywiadów, które rozpoczynają się pytaniem o tematy, które w toku kariery naukowej były rozmówcy z różnych przyczyn i przez różne osoby odradzane. Jedlicki wymienia trzy takie kwestie: Polacy i Żydzi w okresie okupacji, Izrael i Palestyna oraz ateizm i wiara. Zaznacza, że nikt mu nie odradzał ich podejmowania, a jedynie on sam powstrzymywał się przed zabieraniem publicznie głosu w tych sprawach. Wyjaśnia dlaczego się autocenzurował, analizuje, w jaki sposób wszystkie te trzy tematy funkcjonują dziś w polskiej sferze publicznej oraz tłumaczy, dlaczego kilkakrotnie przerwał jednak milczenie.

Corrosion of Zircaloy-clad fuel rods in high-temperature PWRs: Measurement of waterside corrosion in North Anna Unit 1

International Nuclear Information System (INIS)

Balfour, M.G.; Kilp, G.R.; Comstock, R.J.; McAtee, K.R.; Thornburg, D.R.

1992-03-01

Twenty-four peripheral rods and two interior rods from North Anna Unit 1, End-of-Cycle 7, were measured at poolside for waterside corrosion on four-cycle Region 6 assemblies F35 and F66, with rod average burnups of 60 GWD/MTU. Similar measurements were obtained on 24 two-cycle fuel rods from Region 8A assemblies H02 and H10 with average burnups of about 40 GWD/MTU. The Region 6 peripheral rods had been corrosion measured previously after three cycles, at 45 GWD/MTU average burnup. The four-cycle Region 6 fuel rods showed high corrosion, compared to only intermediate corrosion level after three cycles. The accelerated corrosion rate in the fourth cycle was accompanied by extensive laminar cracking and spalling of the oxide film in the thickest regions. The peak corrosion of the two-cycle region 8A rods was 32 μm to 53 μm, with some isolated incipient oxide spalling. In conjunction with the in-reactor corrosion measurements, extensive characterization tests plus long-term autoclave corrosion tests were performed on archive samples of the three major tubing lots represented in the North Anna measurements. The autoclave tests generally showed the same ordering of corrosion by tubing lot as in the reactor; the chief difference between the archive tubing samples was a lower tin content (1.38 percent) for the lot with the lowest corrosion rate compared with a higher tin content (1.58) for the lot with the highest corrosion rate. There was no indication in the autoclave tests of an accelerated rate of corrosion as observed in the reactor

Final Assessment of Manual Ultrasonic Examinations Applied to Detect Flaws in Primary System Dissimilar Metal Welds at North Anna Power Station

Energy Technology Data Exchange (ETDEWEB)

Anderson, Michael T.; Diaz, Aaron A.; Cinson, Anthony D.; Crawford, Susan L.; Prowant, Matthew S.; Doctor, Steven R.

2014-03-24

PNNL conducted a technical assessment of the NDE issues and protocols that led to missed detections of several axially oriented flaws in a steam generator primary inlet dissimilar metal weld at North Anna Power Station, Unit 1 (NAPS-1). This particular component design exhibits a significant outside-diameter (OD) taper that is not included as a blind performance demonstration mock-up within the industry’s Performance Demonstration Initiative, administered by EPRI. For this reason, the licensee engaged EPRI to assist in the development of a technical justification to support the basis for a site-specific qualification. The service-induced flaws at NAPS-1 were eventually detected as a result of OD surface machining in preparation for a full structural weld overlay. The machining operation uncovered the existence of two through-wall flaws, based on the observance of primary water leaking from the dissimilar metal weld. A total of five axially oriented flaws were detected in varied locations around the weld circumference. The field volumetric examination that was conducted at NAPS-1 was a non-encoded, real-time manual ultrasonic examination. PNNL conducted both an initial assessment, and subsequently, a more rigorous technical evaluation (reported here), which has identified an array of NDE issues that may have led to the subject missed detections. These evaluations were performed through technical reviews and discussions with NRC staff, EPRI NDE Center personnel, industry and ISI vendor personnel, and ultrasonic transducer manufacturers, and laboratory tests, to better understand the underlying issues at North Anna.

Use of mock-up training to reduce personnel exposure at the North Anna Unit 1 Steam Generator Replacement Project

Energy Technology Data Exchange (ETDEWEB)

Henry, H.G. [Virginia Power, Mineral, VA (United States); Reilly, B.P. [Bechtel Power Corp., Gaithersburg, MD (United States)

1995-03-01

The North Anna Power Station is located on the southern shore of Lake Anna in Louisa County, approximately forty miles northwest of Richmond, Virginia. The two 910 Mw nuclear units located on this site are owned by Virginia Electric and Power Company (Virginia Power) and Old Dominion Electric Cooperative and operated by Virginia Power. Fuel was loaded into Unit 1 in December 1977, and it began commercial operation in June 1978. Fuel was loaded into Unit 2 in April 1980 and began commercial operation in December 1980. Each nuclear unit includes a three-coolant-loop pressurized light water reactor nuclear steam supply system that was furnished by Westinghouse Electric Corporation. Included within each system were three Westinghouse Model 51 steam generators with alloy 600, mill-annealed tubing material. Over the years of operation of Unit 1, various corrosion-related phenomena had occurred that affected the steam generators tubing and degraded their ability to fulfill their heat transfer function. Advanced inspection and repair techniques helped extend the useful life of the steam generators, but projections based on the results of the inspections indicated that the existing steam generators tubing and degraded their ability to fullfill their heat transfer function. Advanced inspection and repair techniques helped extend the useful life of the steam generators, but projections based on the results of the inspections indicated that the existing steam generators would not last their design life and must be repaired. To this end Virginia Power determined that a steam generator replacement (SGR) program was necessary to remove the old steam generator tube bundles and lower shell sections, including the channel heads (collectively called the lower assemblies), and replace them with new lower assemblies incorporating design features that will prevent the degradation problems that the old steam generators had experienced.

Lack of Association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and Carotid Intima-Media Thickness, Carotid Plaques, and Cardiovascular Disease in Patients with Rheumatoid Arthritis

Directory of Open Access Journals (Sweden)

Raquel López-Mejías

2014-01-01

Full Text Available Introduction. Rheumatoid arthritis (RA is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV mortality. Recent studies have identified the ABO rs579459, PPAP2B rs17114036, and ADAMTS7 rs3825807 polymorphisms as genetic variants associated with coronary artery disease and the PIK3CG rs17398575 and EDNRA rs1878406 polymorphisms as the most significant signals related to the presence of carotid plaque in nonrheumatic Caucasian individuals. Accordingly, we evaluated the potential relationship between these 5 polymorphisms and subclinical atherosclerosis (assessed by carotid intima-media thickness (cIMT and presence/absence of carotid plaques and CV disease in RA. Material and Methods. 2140 Spanish RA patients were genotyped for the 5 polymorphisms by TaqMan assays. Subclinical atherosclerosis was evaluated in 620 of these patients by carotid ultrasonography technology. Results. No statistically significant differences were found when each polymorphism was assessed according to cIMT values and presence/absence of carotid plaques in RA, after adjusting the results for potential confounders. Moreover, no significant differences were obtained when RA patients were stratified according to the presence/absence of CV disease after adjusting for potential confounders. Conclusion. Our results do not confirm association between ABO rs579459, PPAP2B rs17114036, ADAMTS7 rs3825807, PIK3CG rs17398575, and EDNRA rs1878406 and subclinical atherosclerosis and CV disease in RA.

Clinical holistic medicine: the case story of Anna. III. Rehabilitation of philosophy of life during holistic existential therapy for childhood sexual abuse.

Science.gov (United States)

Ventegodt, Søren; Clausen, Birgitte; Merrick, Joav

2006-03-07

When we experience life events with overwhelming emotional pain, we can escape this pain by making decisions (in our mind) that transfer responsibility from our existence to the surrounding world. By doing this, we slowly destroy the essence of our being, health, quality of life, and ability to function. The case of Anna is an excellent example of such a systematic destruction of self, done to survive the extreme pressure from childhood abuse and sexual abuse. The case study shows that the damage done to us by traumatic events is not on our body or soul, but rather our philosophy of life. The important consequence is that we can heal our existence by letting go of the negative decisions taken in the past painful and traumatic situations. By letting go of the life-denying sentences, we come back to life and take responsibility for our own life and existence. The healing of Anna's existence was done by existential holistic therapy. Although the processing did not always run smoothly, as she projected very charged material on the therapists on several occasions, the process resulted in full health and a good quality of life due to her own will to recover and heal completely. The case illustrates the inner logic and complexity of intensive holistic therapy at the most difficult moment, where only a combination of intensive medical, psychiatric, and sexological treatment could set her free. In the paper, we also present a meta-perspective on intensive holistic therapy and its most characteristic phases.

Evaluation of Manual Ultrasonic Examinations Applied to Detect Flaws in Primary System Dissimilar Metal Welds at North Anna Power Station

International Nuclear Information System (INIS)

Anderson, Michael T.; Diaz, Aaron A.; Doctor, Steven R.

2012-01-01

During a recent inservice inspection (ISI) of a dissimilar metal weld (DMW) in an inlet (hot leg) steam generator nozzle at North Anna Power Station Unit 1, several axially oriented flaws went undetected by the licensee's manual ultrasonic testing (UT) technique. The flaws were subsequently detected as a result of outside diameter (OD) surface machining in preparation for a full structural weld overlay. The machining operation uncovered the existence of two through-wall flaws, based on the observance of primary water leaking from the DMW. Further ultrasonic tests were then performed, and a total of five axially oriented flaws, classified as primary water stress corrosion cracking (PWSCC), were detected in varied locations around the weld circumference.

Risk management of the North Anna Power Station Service Water System Preservation Project using the IPE model

International Nuclear Information System (INIS)

Afzali, A.; Donovan, M.D.; Sartain, M.D.; Bankley, A.V.

1993-01-01

This paper discusses the application of the North Anna Power Station Individual Plant Examination (IPE) models in PRA study of the Service Water System Preservation Project (SWSPP). The service water project involves repair and restoration of the Service Water System (SWS) piping and will require excavation of the buried SWS lines in addition to temporarily removing one of the two redundant SWS loops from operation. The SWSPP will be carried out with one or both units in normal operation. The objective of the PRA study was to quantify the risk impact (as measured by the change in Core Damage Frequency (ΔCDF)) of the SWSPP and to identify and evaluate countermeasures to reduce the risk impact of the project activities. The study concluded that the ΔCDF would be acceptable by undertaking preventative measures and by providing additional accident mitigating measures during performance of the SWSPP activities

Dones i violència a Catalunya a finals del franquisme: La terrorista desarmada d’Anna Vilaseca

Directory of Open Access Journals (Sweden)

Montserrat Palau

2015-01-01

Full Text Available Spain suffered under the climate of state terrorism from the dictatorship of 1939 until the 1970s, and during the period including the last years of General Franco’s life to the first years of the transition to democracy. Within this historical context and during the same period, Catalonia suffered more under state terrorism than under the violence of other armed groups. The result of this was that the literature on this subject is either minimal or was written much later. Moreover, the focus on women terrorists was also scarce. Even at present, in situations of armed conflict, women are still seen as victims or as booty – not as active participants in violence. It is the distance in time and context that marks the narrative discourse of La terrorista desarmada (The Unarmed Terrorist (2002 by Anna Vilaseca. The story is set at the end of the Franco regime and illustrates the pervading binaries defining women as submissive and peace-loving.

The Potsdam Parallel Ice Sheet Model (PISM-PIK) - Part 2: Dynamic equilibrium simulation of the Antarctic ice sheet

Science.gov (United States)

Martin, M. A.; Winkelmann, R.; Haseloff, M.; Albrecht, T.; Bueler, E.; Khroulev, C.; Levermann, A.

2011-09-01

We present a dynamic equilibrium simulation of the ice sheet-shelf system on Antarctica with the Potsdam Parallel Ice Sheet Model (PISM-PIK). The simulation is initialized with present-day conditions for bed topography and ice thickness and then run to steady state with constant present-day surface mass balance. Surface temperature and sub-shelf basal melt distribution are parameterized. Grounding lines and calving fronts are free to evolve, and their modeled equilibrium state is compared to observational data. A physically-motivated calving law based on horizontal spreading rates allows for realistic calving fronts for various types of shelves. Steady-state dynamics including surface velocity and ice flux are analyzed for whole Antarctica and the Ronne-Filchner and Ross ice shelf areas in particular. The results show that the different flow regimes in sheet and shelves, and the transition zone between them, are captured reasonably well, supporting the approach of superposition of SIA and SSA for the representation of fast motion of grounded ice. This approach also leads to a natural emergence of sliding-dominated flow in stream-like features in this new 3-D marine ice sheet model.

Two Austro-Hungarian Women Writers, Anna Tutsek and Terka Lux, Creating New Urban Identities in Early Twentieth-Century Budapest

Directory of Open Access Journals (Sweden)

Judit Kádár

2016-01-01

Full Text Available In this paper, I examine some literary texts of two turn-of-the century Hungarian women writers, Anna Tutsek and Terka Lux who left behind their childhood environment in remote regions of the Austro-Hungarian Monarchy in order to move to Budapest, the capital of the eastern part of the Empire. Assuming that individuals hold multiple identities that are flexible and inevitably affected by environmental and social changes, my main focus is on the transformation of their ethnic, regional, occupational and gender identity influenced by the disengagement from their birthplace. Within a context of Hungarian−Eastern-European women's social history, I investigate how migration had led them to reshape their original identities and create new ones and how these emigrant writers reacted to the loss of cultural and social norms in which they had previously lived.

Molecular Basis of Circadian Photoreception

Science.gov (United States)

2006-06-30

267, 16237-16243. Murakami, D.M., Miller, J.D., Fuller, C.A., 1989. The retinohypothalamic tract in the cat: retinal ganglion cell morphology and...Photochem Photobiol B 13, 5-17. Pickard, G.E., 1980. Morphological characteristics of retinal ganglion cells projecting to the suprachiasmatic nucleus: a...from archaea to humans. Annu Rev Cell Dev Biol 16, 365-392. Takahashi, J.S., DeCoursey, P.J., Bauman, L., Menaker, M., 1984. Spectral sensitivity

PIK3CA mutations, PTEN, and pHER2 expression and impact on outcome in HER2-positive early-stage breast cancer patients treated with adjuvant chemotherapy and trastuzumab

DEFF Research Database (Denmark)

Jensen, J D; Knoop, Ann; Laenkholm, A V

2012-01-01

-stage breast cancer patients treated with adjuvant chemotherapy and trastuzumab. PATIENTS AND METHODS: Two hundred and forty HER2-positive early-stage breast cancer patients receiving adjuvant treatment (cyclophosphamide 600 mg/m(2), epirubicin 60 mg/m(2), and fluorouracil 600 mg/m(2)) before administration...... of 1 year trastuzumab were assessable. PTEN and pHER2 expression were assessed by immunohistochemistry. PIK3CA mutations (exons 9 and 20) were determined by pyrosequencing. RESULTS: Five-year overall survival (OS) and invasive disease-free survival were 87.8% and 81.0%, respectively. Twenty-six percent...... activity had a significantly poorer survival despite adequate treatment with adjuvant chemotherapy and trastuzumab....

Kilkanaście sekund. Z Konstantym Gebertem rozmawiają Joanna Tokarska-Bakir, Elżbieta Janicka i Anna Zawadzka

Directory of Open Access Journals (Sweden)

Joanna Tokarska-Bakir

2016-01-01

Full Text Available A few seconds. Konstanty Gebert in a conversation with Joanna Tokarska-Bakir, Elżbieta Janicka and Anna Zawadzka In 2012–2013, Poland was discussing ritual slaughter. Its adversaries claimed that the kind of animal slaughtering that makes the animal meat kosher and halal, causes extra suffering to animals and therefore should be banned. However, the postulate of banning ritual slaughter in Poland is not new and it goes back to the pre-war period. In the Studia Litteraria et Historica’s interview Konstanty Gebert talks about the history of Polish debate on the ritual slaughter, its anti-Semitic applications and about not an­ti-Semitic arguments risen in the discussion. He describes legal solutions for the ritual slaughter in other countries and addresses the issue of animal killing as a moral problem in Judaism. He also discusses the contemporary debate on the ritual slaughter: is it really in the name of the animal rights?   Kilkanaście sekund. Z Konstantym Gebertem rozmawiają Joanna Tokarska-Bakir, Elżbieta Janicka i Anna Zawadzka W latach 2012–2013 przez Polskę przetoczyła się dyskusja o uboju rytualnym. Jego przeciwnicy argumentowali, że taki sposób zabijania zwierząt, by mięso z ich ciał było koszerne i halal, przysparza zwie­rzętom dodatkowych cierpień, dlatego powinien być zakazany. Jednak postulat, by zakazać uboju rytualnego, nie jest w Polsce niczym nowym. Jego tradycja sięga okresu przedwojennego. W wywiadzie dla czasopisma „Studia Litteraria et Historica” Konstanty Gebert opowiada m.in. o historii polskiej debaty na temat uboju rytualnego, o antysemickich z niej użytkach i o nieantysemickich argumentach w niej podnoszonych, o roz­wiązaniach prawnych dotyczących uboju rytualnego w innych krajach, a także o zabijaniu zwierząt jako problemie moralnym w obrębie judaizmu. Zastanawia się także, czy współczesna debata o uboju rytualnym jest faktycznie w interesie zwierząt.

Carl Linnaeus, Erasmus Darwin and Anna Seward: Botanical Poetry and Female Education

Science.gov (United States)

George, Sam

2014-03-01

This article will explore the intersection between `literature' and `science' in one key area, the botanical poem with scientific notes. It reveals significant aspects of the way knowledge was gendered in the Enlightenment, which is relevant to the present-day education of girls in science. It aims to illustrate how members of the Lichfield Botanical Society (headed by Erasmus Darwin) became implicated in debates around the education of women in Linnaean botany. The Society's translations from Linnaeus inspired a new genre of women's educational writing, the botanical poem with scientific notes, which emerged at this time. It focuses in particular on a poem by Anna Seward and argues that significant problems regarding the representation of the Linnaean sexual system of botany are found in such works and that women in the culture of botany struggled to give voice to a subject which was judged improper for female education. The story of this unique poem and the surrounding controversies can teach us much about how gender impacted upon women's scientific writing in eighteenth century Britain, and how it shaped the language and terminology of botany in works for female education. In particular, it demonstrates how the sexuality of plants uncovered by Linnaeus is a paradigmatic illustration of how societal forces can simultaneously both constrict and stimulate women's involvement in science. Despite the vast changes to women's access in scientific knowledge of the present day, this `fair sexing' of botany illustrates the struggle that women have undergone to give voice to their botanical knowledge.

The Potsdam Parallel Ice Sheet Model (PISM-PIK – Part 2: Dynamic equilibrium simulation of the Antarctic ice sheet

Directory of Open Access Journals (Sweden)

M. A. Martin

2011-09-01

Full Text Available We present a dynamic equilibrium simulation of the ice sheet-shelf system on Antarctica with the Potsdam Parallel Ice Sheet Model (PISM-PIK. The simulation is initialized with present-day conditions for bed topography and ice thickness and then run to steady state with constant present-day surface mass balance. Surface temperature and sub-shelf basal melt distribution are parameterized. Grounding lines and calving fronts are free to evolve, and their modeled equilibrium state is compared to observational data. A physically-motivated calving law based on horizontal spreading rates allows for realistic calving fronts for various types of shelves. Steady-state dynamics including surface velocity and ice flux are analyzed for whole Antarctica and the Ronne-Filchner and Ross ice shelf areas in particular. The results show that the different flow regimes in sheet and shelves, and the transition zone between them, are captured reasonably well, supporting the approach of superposition of SIA and SSA for the representation of fast motion of grounded ice. This approach also leads to a natural emergence of sliding-dominated flow in stream-like features in this new 3-D marine ice sheet model.

‘The Good Terrorist(s’? Interrogating Gender and Violence in Ann Devlin’s ‘Naming the Names’ and Anna Burns’ No Bones

Directory of Open Access Journals (Sweden)

Fiona McCann

2012-03-01

Full Text Available This paper aims to analyse the depiction of IRA female volunteers in Ann Devlin’s “Naming the Names” (1986 and Anna Burns’ No Bones (2001 and to consider the relationship established between gender and violence in these texts. I investigate the extent to which the female terrorists portrayed conform to the “mother, monster, whore” paradigm identified by Laura Sjoberg and Caron Gentry (2007 in their study of women’s violence in global politics and consider what differences, if any, are established with these characters’ male counterparts. The ways in which both authors destabilise traditional gender stereotypes is also explored, as is the question of whether these texts might be considered as feminist fictions.

Mevlana’nın Menkıbeleri Üzerine Folklorik Bir İnceleme A Folkloric Analysis on the Legends of Mevlana

Directory of Open Access Journals (Sweden)

Gülay KARAMAN

2012-09-01

Full Text Available behavior to be proud of. Its plural form menakıb for the first time in this meaning, is used in the corpus of hadith which had been written and compiled by IXth century to describe the virtues of prophet Muhammed and his companians. Furthermore, writings consist of the biography of historical personages, the description of works of worthies and even some of the holy cities are also called menakıb. While at the begining menakıbnames were created in order to describe high moral values of both the prophet Muhammed and his companians in later periods, the lives of some important men of sufism and religious orders were also added to this account. The first known example of Türkish menakıbname literature is Tezkire-i Satuk Buğra Han which is from Karahanlı period. Turkish menakıbname literature that begun with Tezkire-i Satuk Buğra Han, also continued to spread quickly among the Muslim Turks came to Anatolia and settled by migrations. Since the author is a member of his own society naturally his work will be a mirror to social, cultural, economical, political life of its century. For this reason, menakıbnames which tell the extraordinary life stories of saints are very important sources of information especially for history, culture, folklore and literature. After careful studies on the legends it can be possible to reach very rich source of information. In Türkiye, Fuad Köprülü is the first name with his work called as Türk Edebiyatında İlk Mutasavvıflar who pointed out using menakıbnames in scientific studies. In this study we want to call attention to Menâkıbu’l-Ârifîn which tells the legends of Mevlana and the other Mevlevi saints. Menâkıbu’l-Ârifîn is written by Mevlevi Ahmed Eflâkî in 14th century after the request of his sheik Ulu Arif Çelebi in Persian. This menakıbname has a certain place in Turkish history and culture since it gives first-hand information about Mevlana and the other Mevlevi saints. In this

The innovation of the subspecialty of Paediatric Virology: An interview with Research Professor of Molecular Virology Anna Kramvis.

Science.gov (United States)

Mammas, Ioannis N; Spandidos, Demetrios A

2017-10-01

Professor Anna Kramvis, Research Professor of Molecular Virology at the University of the Witwatersrand in Johannesburg, South Africa, talks about direct-acting antiviral treatments against hepatitis C virus (HCV), as well as the perspective of the development of an effective vaccine against HCV. She emphasises the necessity of vaccination against hepatitis B virus (HBV), highlighting that it is very important that vaccination should be administered at birth in order to prevent mother-to-child transmission (MTCT) of HBV. Professor Kramvis states that vaccination against HBV is safe and that HBV and HCV infections are not contraindications for breastfeeding. Regarding the challenge of Paediatric Virology, she believes that it is a field that during the last years is increasing exponentially, while she concurs that Paediatric Virology subspecialty will be a popular choice for infectious diseases subspecialists. In the context of the 3rd Workshop on Paediatric Virology, which will be held in Athens on October 7th, 2017, Professor Kramvis will give her key lecture on MTCT of HBV and HCV.

THE IMPACT OF TRANSLATION TECHNIQUES AND SUBTITLING RULES TO THE EQUIVALENCE OF MEANING OF CULINARY TERMS IN THE FRESH WITH ANNA OLSON SEASON 1 SUBTITLE

Directory of Open Access Journals (Sweden)

Hetty Hartati Novita

2017-12-01

Full Text Available The emergence of cable TV in Indonesia has made this author interested in focusing on the topic of culinary terms translation in the subtitle of Fresh with Anna Olson Season 1 program broadcasted on Asian Food Channel station. In this paper, this author analyzes the translation techniques suggested by Molina and Albir used by the translators to create the more accurate, natural, and communicative subtitle even though there are subtitling rules to follow. The result is, most of the translated terms have equivalence in meaning between the ST and the TT, while the ones which are not equivalent are due to the application of two particular techniques, Discursive Creation and Adaptation.

Babesia (Theileria) annae in a red fox (Vulpes vulpes) from Prince Edward Island, Canada.

Science.gov (United States)

Clancey, Noel; Horney, Barbara; Burton, Shelley; Birkenheuer, Adam; McBurney, Scott; Tefft, Karen

2010-04-01

A 4-6-mo-old female red fox (Vulpes vulpes) was presented to the Atlantic Veterinary College (AVC) Teaching Hospital, Prince Edward Island, Canada. On presentation, the fox was weak and had pale mucous membranes. A complete blood count and a serum biochemistry profile were performed. Blood smear examination revealed low numbers of erythrocytes containing centrally to paracentrally located, single, rarely multiple, approximately 1 x 2 microm, oval to round organisms with morphology similar to Babesia microti. Polymerase chain reaction testing and DNA sequencing of the Babesia species 18S rRNA gene were performed on DNA extracted from whole blood. Results were positive for a Babesia microti-like parasite genetically identical to Babesia (Theileria) annae. The fox was euthanized due to poor prognosis for recovery. Necropsy examination revealed multifocal to locally extensive subacute nonsuppurative meningoencephalitis, an eosinophilic broncho-pneumonia, a moderate diffuse vacuolar hepatopathy, and lesions associated with blunt trauma to the left abdominal region. This is the first reported case of a red fox in Canada infected with a piroplasm. It remains uncertain whether the presence of this hemoparasite in this fox was pathogenic or an incidental finding. The potential for competent vectors of Babesia species on Prince Edward Island, the potential for this Babesia microti-like parasite to infect other wild and domestic canids, and the significance of this parasite to the health of infected individuals are yet to be determined.

Linguagem experimental: o discurso do consumo em Sexo, de André Sant'Anna, e o discurso da 'existencialidade' , em Lugar público, de José Agrippino de Paula

OpenAIRE

Romulo de Almeida Portella

2006-01-01

O objetivo principal desta dissertação é investigar as obras Sexo, de André SantAnna, e Lugar Público, de José Agrippino de Paula, a partir das noções que lidam com a vitalidade das formulações verbais, no que dizem respeito à elaboração da linguagem literária e a estruturação desta como conhecimento a ser apreendido. O trabalho contribui para um melhor entendimento da estética do experimentalismo, que é abordada em tais narrativas ficcionais. This dissertations main aim is to inves...

Infantile anorexia, co-excitation and co-mastery in the parent/baby cathexis: The contribution of Sigmund and Anna Freud.

Science.gov (United States)

Cascales, Thomas

2017-04-01

Recent epidemiological studies show that 2% of babies in ordinary paediatric clinics suffer from infantile anorexia. In the first part of this paper we present a case study from our hospital clinical activity. Our framework combines clinical psychoanalytic sessions and perinatal videos. In the second part, we will focus on the concepts of instinct and excitation proposed by Sigmund Freud and the concept of mastery proposed by Anna Freud. In the third part, we will examine these concepts in the light of the case study. The fourth part is devoted to clinical recommendations from our hospital psychoanalytic practice. In conclusion, unlike other clinical settings, the psychoanalytic setting allows for the elaboration of the parental hatred included in the libidinal cathexis. Our psychoanalytic setting (sessions/videos) makes it possible to decontaminate parental intrapsychic elements overloaded with excitement, saturated with hate elements, and rendered sterile by the instinct for mastery. An initial part of the treatment process involves working through the intersubjective elements observed in the video. Copyright © 2016 Institute of Psychoanalysis.

Bohemia as the Homeland of the Soul in the Letters of Marina Tsvetaeva to Anna Teskova

Directory of Open Access Journals (Sweden)

Massimo Tria

2014-03-01

Full Text Available The article examines the letters sent by Marina Tsvetaeva to the translator and public figure Anna Teskova, who was one of the few poet’s Czech intimate friends, whom she met during her stay in Czechoslovakia (1922-1925. In the first part of the paper the Author focuses on the echoes of Prague and its culture in this specific correspondence, trying to ascertain to which extent Marina Tsvetaeva was acquainted with the cultural world she lived in: the lack of knowledge of the Czech language and the limited relationships with Prague intellectuals didn’t allow her to get a deep insight of the Czech cultural milieu. The textual analysis of the letters, though, on the basis of key concepts as “родной”, “родина”, “честь”, confirms the presence of a persistent feeling of Prague-homesickness in Tsvetaeva’s psycho- logical world, which brought her to develop an alternative model of Homeland, substitute to her native Russia and to Germany, which disappointed her after the rise of the Nazi Regime. Through this unique correspondence (including the first part of her Verses dedicated to Bohemia we gain the certainty that Tsvetaeva discovered in Prague and in the Czech lands an idealized model of a pacific, beautiful and faithful Homeland.

Pengembangan Sistem Pengelolaan Informasi Pusat Informasi dan Konseling Remaja Kota Padang

Directory of Open Access Journals (Sweden)

Isra Wilna

2017-04-01

Full Text Available Salah satu fungsi dari Pusat Informasi dan Konseling Remaja (PIK Remaja adalah memberikan pelayanan informasi dan konseling tentang perencanaan kehidupan berkeluarga bagi remaja. PIK Remaja ini terdapat di lembaga pendidikan sepert sekolah dan perguruan tinggi maupun lembaga non pendidikan. Lokasinya tersebar di 11 kecamatan yang ada di Kota Padang. Setiap PIK, diharuskan menyampaikan laporan-nya secara kolektif dan berkala ke Badan Pemberdayaan Masyarakat, Perempuan dan Keluarga Berencana (BPMPKB  Padang,. Keterbatasan ruang dan waktu, menjadi kendala bagi BPMPKB dalam menjalan perannya sebagai pengawas. Disamping itu, perubahan alamat kantor PIK Remaja  banyak tidak terkelola karena tidak terdokumentasi dengan baik. Oleh karena itu dibangun sebuah sistem yang mampu menyelesaikan masalah tersebut. Sistem infomasi geografis menjadi pilihan karena mampu menyajikan informasi dengan referensi geografis. Dukungan teknologi web terhadap visualisasi geografis akan memudahkan pemangku kebijakan dalam pengembangan PIK Remaja di Kota Padang. Metode pengembangan aplikasi mengadopsi model waterfall. Aplikasi ini dibangun dengan fungsional pencarian PIK Remaja berdasarkan kategori, berdasarkan wilayah, pencarian PIK Remaja yang terdekat dari posisi pengguna, melihat rute menuju PIK Remaja yang dipilih. Disamping itu BPMPKB dapat mengelola data dan laporan  kegiatan PIK remaja. Disamping itu, PIK Remaja dapat mengelola data PIK-nya dan menyampaikan laporan kegiatan. Semua data tesimpan dalam database terdiri dari 9 tabel dengan  17 rancangan user interface aplikasi. Pengujian dilakukan dengan validasi fungsional aplikasi yang dirancang dengan aplikasi secara Blackbox testing. Pengujian ini  melibatkan 5 orang pengguna dengan hasil rekomendasi fungsional dari sistem telah berjalan sesuai dengan rancangan.   Kata kunci: PIK Remaja, Sistem Informasi Geografis.

GLYCINE-RICH RNA-BINDING PROTEIN1 interacts with RECEPTOR-LIKE CYTOPLASMIC PROTEIN KINASE1 and suppresses cell death and defense responses in pepper (Capsicum annuum).

Science.gov (United States)

Kim, Dae Sung; Kim, Nak Hyun; Hwang, Byung Kook

2015-01-01

Plants use a variety of innate immune regulators to trigger cell death and defense responses against pathogen attack. We identified pepper (Capsicum annuum) GLYCINE-RICH RNA-BINDING PROTEIN1 (CaGRP1) as a RECEPTOR-LIKE CYTOPLASMIC PROTEIN KINASE1 (CaPIK1)-interacting partner, based on bimolecular fluorescence complementation and coimmunoprecipitation analyses as well as gene silencing and transient expression analysis. CaGRP1 contains an N-terminal RNA recognition motif and a glycine-rich region at the C-terminus. The CaGRP1 protein had DNA- and RNA-binding activity in vitro. CaGRP1 interacted with CaPIK1 in planta. CaGRP1 and CaGRP1-CaPIK1 complexes were localized to the nucleus in plant cells. CaPIK1 phosphorylated CaGRP1 in vitro and in planta. Transient coexpression of CaGRP1 with CaPIK1 suppressed the CaPIK1-triggered cell death response, accompanied by a reduced CaPIK1-triggered reactive oxygen species (ROS) burst. The RNA recognition motif region of CaGRP1 was responsible for the nuclear localization of CaGRP1 as well as the suppression of the CaPIK1-triggered cell death response. CaGRP1 silencing in pepper conferred enhanced resistance to Xanthomonas campestris pv vesicatoria (Xcv) infection; however, CaPIK1-silenced plants were more susceptible to Xcv. CaGRP1 interacts with CaPIK1 and negatively regulates CaPIK1-triggered cell death and defense responses by suppressing ROS accumulation. © 2014 The Authors. New Phytologist © 2014 New Phytologist Trust.

Conformance to Generic Letter 83-28, Items 3.1.3 and 3.2.3, Beaver Valley, Unit No. 1, North Anna, Unit Nos. 1 and 2, Surry Unit Nos. 1 and 2 (Docket Nos. 50-334, 50-338, 50-339, 50-280, and 50-281)

International Nuclear Information System (INIS)

Haroldsen, R.

1985-09-01

This report provides a review of the submittals for Beaver Valley, Unit No. 1, North Anna, Unit Nos. 1 and 2, and Surry, Unit Nos. 1 and 2, for conformance to Generic Letter 83-28, Items 3.1.3 and 3.2.3. The specific plants selected were reviewed as a group because of similarity in type and applicability of review items

Decoupling of the PI3K Pathway via Mutation Necessitates Combinatorial Treatment in HER2+ Breast Cancer.

Directory of Open Access Journals (Sweden)

James E Korkola

Full Text Available We report here on experimental and theoretical efforts to determine how best to combine drugs that inhibit HER2 and AKT in HER2(+ breast cancers. We accomplished this by measuring cellular and molecular responses to lapatinib and the AKT inhibitors (AKTi GSK690693 and GSK2141795 in a panel of 22 HER2(+ breast cancer cell lines carrying wild type or mutant PIK3CA. We observed that combinations of lapatinib plus AKTi were synergistic in HER2(+/PIK3CA(mut cell lines but not in HER2(+/PIK3CA(wt cell lines. We measured changes in phospho-protein levels in 15 cell lines after treatment with lapatinib, AKTi or lapatinib + AKTi to shed light on the underlying signaling dynamics. This revealed that p-S6RP levels were less well attenuated by lapatinib in HER2(+/PIK3CA(mut cells compared to HER2(+/PIK3CAwt cells and that lapatinib + AKTi reduced p-S6RP levels to those achieved in HER2(+/PIK3CA(wt cells with lapatinib alone. We also found that that compensatory up-regulation of p-HER3 and p-HER2 is blunted in PIK3CA(mut cells following lapatinib + AKTi treatment. Responses of HER2(+ SKBR3 cells transfected with lentiviruses carrying control or PIK3CA(mut sequences were similar to those observed in HER2(+/PIK3CA(mut cell lines but not in HER2(+/PIK3CA(wt cell lines. We used a nonlinear ordinary differential equation model to support the idea that PIK3CA mutations act as downstream activators of AKT that blunt lapatinib inhibition of downstream AKT signaling and that the effects of PIK3CA mutations can be countered by combining lapatinib with an AKTi. This combination does not confer substantial benefit beyond lapatinib in HER2+/PIK3CA(wt cells.

Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides

DEFF Research Database (Denmark)

Almutairi, Mashal M; Park, Sung Ryeol; Rose, Simon

2015-01-01

venezuelae strain ATCC 15439. The producer avoids the inhibitory effects of its own antibiotics by expressing two paralogous rRNA methylase genes pikR1 and pikR2 with seemingly redundant functions. We show here that the PikR1 and PikR2 enzymes mono- and dimethylate, respectively, the N6 amino group in 23S r...

Role of Class III phosphoinositide 3-kinase in the brain development: possible involvement in specific learning disorders.

Science.gov (United States)

Inaguma, Yutaka; Matsumoto, Ayumi; Noda, Mariko; Tabata, Hidenori; Maeda, Akihiko; Goto, Masahide; Usui, Daisuke; Jimbo, Eriko F; Kikkawa, Kiyoshi; Ohtsuki, Mamitaro; Momoi, Mariko Y; Osaka, Hitoshi; Yamagata, Takanori; Nagata, Koh-Ichi

2016-10-01

Class III phosphoinositide 3-kinase (PIK3C3 or mammalian vacuolar protein sorting 34 homolog, Vps34) regulates vesicular trafficking, autophagy, and nutrient sensing. Recently, we reported that PIK3C3 is expressed in mouse cerebral cortex throughout the developmental process, especially at early embryonic stage. We thus examined the role of PIK3C3 in the development of the mouse cerebral cortex. Acute silencing of PIK3C3 with in utero electroporation method caused positional defects of excitatory neurons during corticogenesis. Time-lapse imaging revealed that the abnormal positioning was at least partially because of the reduced migration velocity. When PIK3C3 was silenced in cortical neurons in one hemisphere, axon extension to the contralateral hemisphere was also delayed. These aberrant phenotypes were rescued by RNAi-resistant PIK3C3. Notably, knockdown of PIK3C3 did not affect the cell cycle of neuronal progenitors and stem cells at the ventricular zone. Taken together, PIK3C3 was thought to play a crucial role in corticogenesis through the regulation of excitatory neuron migration and axon extension. Meanwhile, when we performed comparative genomic hybridization on a patient with specific learning disorders, a 107 Kb-deletion was identified on 18q12.3 (nt. 39554147-39661206) that encompasses exons 5-23 of PIK3C3. Notably, the above aberrant migration and axon growth phenotypes were not rescued by the disease-related truncation mutant (172 amino acids) lacking the C-terminal kinase domain. Thus, functional defects of PIK3C3 might impair corticogenesis and relate to the pathophysiology of specific learning disorders and other neurodevelopmental disorders. Acute knockdown of Class III phosphoinositide 3-kinase (PIK3C3) evokes migration defects of excitatory neurons during corticogenesis. PIK3C3-knockdown also disrupts axon outgrowth, but not progenitor proliferation in vivo. Involvement of PIK3C3 in neurodevelopmental disorders might be an interesting future

Relación entre la variación de las condiciones ambientales y la temperatura interna de la yema del manzano 'Anna' Inner bud temperature of' Anna' apple trees in relation to varying environmental conditions

Directory of Open Access Journals (Sweden)

Casierra Posada Fannor

2001-12-01

Full Text Available En Paipa (Colombia, se realizó un ensayo de campo con el fin de determinar el efecto de la variación de las condiciones ambientales sobre la temperatura interna de la yema del manzano 'Anna' cultivado en condiciones de altiplano tropical. Los registros se hicieron en un árbol de cuatro años, el cual se defolió manualmente y se podó pocas semanas después de la cosecha. Se midió la temperatura del aire y se comparó con la temperatura de una yema en el árbol. Para medir la temperatura de la yema se colocó un sensor digital muy delgado entre los catáfilos de la yema; la temperatura ambiente se registró con un termómetro de bulbo. Las mediciones se realizaron cada media hora entre las 7:00 y las 17:30 horas del día, durante 19 días, empezando el día en que el árbol fue defoliado hasta cuando la yema alcanzó el estado fenológico "green tip". Al tiempo con cada medición de temperatura se registró el fenómeno climático más sobresaliente (lluvia, tiempo soleado, viento, tiempo nublado, etc. y los datos se agruparon según cada fenómeno climático. Los resultados mostraron que la yema presentó una temperatura 1,49°C por encima de la temperatura del aire durante el transcurso del día, en la noche no hubo diferencia de temperatura. En condiciones de lluvia, la temperatura
de la yema estuvo 0,57°C por encima de la temperatura
del aire. Bajo cielo nublado la yema estuvo 0,56°C más cálida
que el aire. En condiciones de viento la yema presentó una
diferencia de 0,87°C sobre la temperatura del aire. En días
soleados, la yema mantuvo una temperatura 2,3°C sobre la temperatura del aire. Las diferencias entre la temperatura del aire y la de la yema se discuten con base en la transpiración, la convección y la radiación.A field experiment was conducted in Paipa (Colombia to study the effect of environmental varying over inner bud temperature of an 'Anna' apple tree 4 years old growing in tropical

Characterization techniques for nano-electronics, with emphasis to electron microscopy. The role of the European Project ANNA

Science.gov (United States)

Armigliato, A.

2008-07-01

, however, European laboratories with high-level expertise in materials characterization still operate in a largely independent way; this adversely affects the competitivity of European science and industry at the international level. For this reason the European Commission has started an Integrated Infrastructure Initiative (I3) in the sixth Framework Programme (now continuing in FP7) and funded a project called ANNA (2006-2010). This acronym stands for European Integrated Activity of Excellence and Networking for Nano and Micro- Electronics Analysis. The consortium includes 12 partners from 7 European countries and is coordinated by the Fondazione B.Kessler (FBK) in Trento (Italy); CNR-IMM is one of the 12 partners. Aim of ANNA is the onset of strong, long-term collaboration among the partners, so to form an integrated multi-site analytical facility, able to offer to the European community a wide variety of top-level analytical expertise and services in the field of micro- and nano-electronics. They include X-ray diffraction and scattering, SIMS, electron microscopy, medium-energy ion scattering, optical and electrical techniques. The project will be focused on three main activities: Networking (standardization of samples and methodologies, establishment of accredited reference laboratories), Transnational Access to laboratories located in the partners' premises to perform specific analytical experiments (an example is given by the two STEM methodologies discussed above) and Joint Research activity, which is targeted at the improvement and extension of the methodologies through a continuous instrumental and technical development. It is planned that the European joint analytical laboratory will continue its activity beyond the end of the project in 2010.

The influence of the fault zone width on land surface vibrations after the high-energy tremor in the "Rydułtowy-Anna" hard coal mine

Science.gov (United States)

Pilecka, Elżbieta; Szwarkowski, Dariusz

2018-04-01

In the article, a numerical analysis of the impact of the width of the fault zone on land surface tremors on the area of the "Rydułtowy - Anna" hard coal mine was performed. The analysis covered the dynamic impact of the actual seismic wave after the high-energy tremor of 7 June 2013. Vibrations on the land surface are a measure of the mining damage risk. It is particularly the horizontal components of land vibrations that are dangerous to buildings which is reflected in the Mining Scales of Intensity (GSI) of vibrations. The run of a seismic wave in the rock mass from the hypocenter to the area's surface depends on the lithology of the area and the presence of fault zones. The rock mass network cut by faults of various widths influences the amplitude of tremor reaching the area's surface. The analysis of the impact of the width of the fault zone was done for three alternatives.

Frequent alterations of the PI3K/AKT/mTOR pathways in hereditary nonpolyposis colorectal cancer

DEFF Research Database (Denmark)

Ekstrand, Anna Isinger; Jönsson, Mats; Lindblom, Annika

2010-01-01

The phosphatidylinositol 3-kinases-AKT-mammalian target of rapamycin pathway (PI3K/AKT/mTOR) is central in colorectal tumors. Data on its role in hereditary cancers are, however, scarce and we therefore characterized mutations in PIK3CA and KRAS, and expression of PIK3CA, phosphorylated AKT......, and PTEN in colorectal cancers linked to hereditary nonpolyposis colorectal cancer (HNPCC). Sequencing was used to identify mutations in PIK3CA, a real-time PCR-based method to identify KRAS mutations, and immunohistochemical staining was used to evaluate the expression of PIK3CA, phosphorylated AKT...... and PTEN in 58 HNPCC-associated colorectal cancers. Derangements of at least one of the PI3K/AKT/mTOR components analyzed were found in 51/58 (88%) tumors. Mutations in PIK3CA and KRAS were identified in 14 and 31% of the tumors respectively. Overexpression of PIK3CA and phosphorylated AKT occurred in 59...

„No i co z tego”. O dyskusji wokół "Kamieni na szaniec" Aleksandra Kamińskiego z Bożeną Keff, Magdą Szcześniak, Tomaszem Tomasikiem i Błażejem Warkockim rozmawia Anna Zawadzka

Directory of Open Access Journals (Sweden)

Anna Zawadzka

2016-01-01

Full Text Available “So what?” Bożena Keff, Magda Szcześniak, Tomasz Tomasik & Błażej Warkocki in a conversation with Anna Zawadzka In April 2013, the Polish Press Agency published an article in which Elżbieta Janicka proposed a new interpretations of Stones on the barricades. She claimed i.a.: ”Since we are deliberating, placed in a ho-mophobic culture, where questioning someone’s heterosexual orientation is not an observation but a de­lation, I would compare Zośka and Rudy to Achilles and Patroclus, a pair of legendary warriors. […] I think that this is one of the most beautiful texts about love knowing no limits, whereas all we know about the main characters’ relations testifies to the unheard power and depth of this feeling”. Those words caused an avalanche of reactions, starting from polemics with Janicka or libels on her to violence threats against the scholar. In this conversation, Bożena Keff, Magda Szcześniak, Tomasz Tomasik, Błażej Warkocki and Anna Zawadzka are discussing Janicka’s proposition (developed in her book Festung Warschau, published prior to the quoted text to interpret Stones on the barricades as a text also on a romantic relationship between two men. They analyse social and political causes of the “scandal”, induced by the Polish mainstream media together with a part of the Polish academic milieu. This conversation took place in May 2013.   „No i co z tego”. O dyskusji wokół Kamieni na szaniec Aleksandra Kamińskiego z Bożeną Keff, Magdą Szcześniak, Tomaszem Tomasikiem i Błażejem Warkockim rozmawia Anna Zawadzka W kwietniu 2013 roku Polska Agencja Prasowa opublikowała artykuł, w którym Elżbieta Janicka proponowała nowe interpretacje Kamieni na szaniec. Janicka mówiła m.in.: „Ponieważ rozmawiamy w kulturze homofobicznej, gdzie zakwestionowanie czyjejś heteroseksualnej orientacji nie jest konstatacją, lecz denuncjacją, porównałabym Zośkę i Rudego do Achillesa i Patroklesa, pary

Phosphoinositide Kinase-3 Status Associated With Presence or Absence of Human Papillomavirus in Head and Neck Squamous Cell Carcinomas

International Nuclear Information System (INIS)

Yarbrough, Wendell G.; Whigham, Amy; Brown, Brandee; Roach, Michael; Slebos, Robbert

2007-01-01

Purpose: To investigate phosphoinositide kinase-3 (PI3K) activation in relation to human papillomavirus (HPV) status in head and neck squamous cell carcinoma (HNSCC). Methods and Materials: Gene expression microarray data were analyzed to determine differentially expressed genes between HPV(+) and HPV(-) HNSCC. PIK3CA gene expression was confirmed by quantitative reverse transcriptase-polymerase chain reaction in seven HPV(+) and seven HPV(-) primary HNSCCs. PIK3CA mutation status in three HPV(+) and nine HPV(-) cell lines was determined by polymerase chain reaction amplification of hot spot exons (1, 9, 20) followed by direct sequencing. Results: PIK3CA was overexpressed in HPV(+)-associated HNSCC compared with the expression in HPV(-) HNSCC. Activation of PIK3CA by mutation was found in 1 of the 12 tested HNSCC cell lines. Conclusion: Activation of PI3K by mutation of PIK3CA is rare in HNSCC cell lines and was not found in three HPV(+) cell lines. One mechanism by which HPV-associated HNSCC might activate PI3K is increased expression of PIK3CA

American Nephrology Nurses' Association

Science.gov (United States)

... Join/Renew Jobs Contact Corporate Shop American Nephrology Nurses Association About ANNA Association About ANNA Strategic Plan ... CExpress Events National Events Chapter / Local Events Nephrology Nurses Week ANNA Education Modules CKD Modules Education Services ...

Genome-wide analysis of the phosphoinositide kinome from two ciliates reveals novel evolutionary links for phosphoinositide kinases in eukaryotic cells.

Directory of Open Access Journals (Sweden)

George Leondaritis

Full Text Available BACKGROUND: The complexity of phosphoinositide signaling in higher eukaryotes is partly due to expansion of specific families and types of phosphoinositide kinases (PIKs that can generate all phosphoinositides via multiple routes. This is particularly evident in the PI3Ks and PIPKs, and it is considered an evolutionary trait associated with metazoan diversification. Yet, there are limited comprehensive studies on the PIK repertoire of free living unicellular organisms. METHODOLOGY/PRINCIPAL FINDINGS: We undertook a genome-wide analysis of putative PIK genes in two free living ciliated cells, Tetrahymena and Paramecium. The Tetrahymena thermophila and Paramecium tetraurelia genomes were probed with representative kinases from all families and types. Putative homologs were verified by EST, microarray and deep RNA sequencing database searches and further characterized for domain structure, catalytic efficiency, expression patterns and phylogenetic relationships. In total, we identified and characterized 22 genes in the Tetrahymena thermophila genome and 62 highly homologues genes in Paramecium tetraurelia suggesting a tight evolutionary conservation in the ciliate lineage. Comparison to the kinome of fungi reveals a significant expansion of PIK genes in ciliates. CONCLUSIONS/SIGNIFICANCE: Our study highlights four important aspects concerning ciliate and other unicellular PIKs. First, ciliate-specific expansion of PI4KIII-like genes. Second, presence of class I PI3Ks which, at least in Tetrahymena, are associated with a metazoan-type machinery for PIP3 signaling. Third, expansion of divergent PIPK enzymes such as the recently described type IV transmembrane PIPKs. Fourth, presence of possible type II PIPKs and presumably inactive PIKs (hence, pseudo-PIKs not previously described. Taken together, our results provide a solid framework for future investigation of the roles of PIKs in ciliates and indicate that novel functions and novel regulatory

Davaite budem nemnogo glupõmi / Luiza Mishina

Index Scriptorium Estoniae

Mishina, Luiza

1996-01-01

Nagibin, Juri. Tma v kontse tunnelja. Moja zolotaja teshtsha : Povesti. Moskva : PIK, 1994; Nagibin, Juri. Dafnis i Hloja epohhi kulta litshnosti, voljuntarisma i zastoja : Istorija odnoi ljubvi. Moskva : PIK, 1995

Modernizing the 5G 100/8 piston compressor by means of directly streaming valves

Energy Technology Data Exchange (ETDEWEB)

Tsvetanov, Ts.; Stoyanov, I.

1988-02-01

Deals with 5G 100/8 air compressors which, despite long service and lack of spare parts, are still widely used in Bulgarian underground coal mines. K-4-10 ring-type valves are in particularly short supply; maintenance engineers have been forced to modify the compresors. Initially, Bulgarian KP-3.1 valves with direct air streaming replaced the K-4-10; these were later replaced by PIK-220 and PIK-220A valves. Tests on overhauled compressors have shown that replacing the KP-3.1 with the PIK-220 or PIK-220A can result in a saving of up to 100,000 kWh of electricity per compressor. Details of reconstruction and testing of piston compressors are included. 10 refs.

IDH2 Mutations Define a Unique Subtype of Breast Cancer with Altered Nuclear Polarity

Science.gov (United States)

Chiang, Sarah; Weigelt, Britta; Wen, Huei-Chi; Pareja, Fresia; Raghavendra, Ashwini; Martelotto, Luciano G.; Burke, Kathleen A.; Basili, Thais; Li, Anqi; Geyer, Felipe C.; Piscuoglio, Salvatore; Ng, Charlotte K.Y.; Jungbluth, Achim A.; Balss, Jörg; Pusch, Stefan; Baker, Gabrielle M.; Cole, Kimberly S.; von Deimling, Andreas; Batten, Julie M.; Marotti, Jonathan D.; Soh, Hwei-Choo; McCalip, Benjamin L.; Serrano, Jonathan; Lim, Raymond S.; Siziopikou, Kalliopi P.; Lu, Song; Liu, Xiaolong; Hammour, Tarek; Brogi, Edi; Snuderl, Matija; Iafrate, A. John; Reis-Filho, Jorge S.; Schnitt, Stuart J.

2017-01-01

Solid papillary carcinoma with reverse polarity (SPCRP) is a rare breast cancer subtype with an obscure etiology. In this study, we sought to describe its unique histopathologic features and to identify the genetic alterations that underpin SPCRP using massively parallel whole-exome and targeted sequencing. The morphologic and immunohistochemical features of SPCRP support the invasive nature of this subtype. Ten of 13 (77%) SPCRPs harbored hotspot mutations at R172 of the isocitrate dehydrogenase IDH2, of which 8 of 10 displayed concurrent pathogenic mutations affecting PIK3CA or PIK3R1. One of the IDH2 wild-type SPCRPs harbored a TET2 Q548* truncating mutation coupled with a PIK3CA H1047R mutation. Functional studies demonstrated that IDH2 and PIK3CA hotspot mutations are likely drivers of SPCRP, resulting in its reversed nuclear polarization phenotype. Our results offer a molecular definition of SPCRP as a distinct breast cancer subtype. Concurrent IDH2 and PIK3CA mutations may help diagnose SPCRP and possibly direct effective treatment. PMID:27913435

Multiple metabolic alterations exist in mutant PI3K cancers, but only glucose is essential as a nutrient source.

Directory of Open Access Journals (Sweden)

Rebecca Foster

Full Text Available Targeting tumour metabolism is becoming a major new area of pharmaceutical endeavour. Consequently, a systematic search to define whether there are specific energy source dependencies in tumours, and how these might be dictated by upstream driving genetic mutations, is required. The PI3K-AKT-mTOR signalling pathway has a seminal role in regulating diverse cellular processes including cell proliferation and survival, but has also been associated with metabolic dysregulation. In this study, we sought to define how mutations within PI3KCA may affect the metabolic dependency of a cancer cell, using precisely engineered isogenic cell lines. Studies revealed gene expression signatures in PIK3CA mutant cells indicative of a consistent up-regulation of glycolysis. Interestingly, the genes up- and down-regulated varied between isogenic models suggesting that the primary node of regulation is not the same between models. Additional gene expression changes were also observed, suggesting that metabolic pathways other than glycolysis, such as glutaminolysis, were also affected. Nutrient dependency studies revealed that growth of PIK3CA mutant cells is highly dependent on glucose, whereas glutamine dependency is independent of PIK3CA status. In addition, the glucose dependency exhibited by PIK3CA mutant cells could not be overridden by supplementation with other nutrients. This specific dependence on glucose for growth was further illustrated by studies evaluating the effects of targeted disruption of the glycolytic pathway using siRNA and was also found to be present across a wider panel of cancer cell lines harbouring endogenous PIK3CA mutations. In conclusion, we have found that PIK3CA mutations lead to a shift towards a highly glycolytic phenotype, and that despite suggestions that cancer cells are adept at utilising alternative nutrient sources, PIK3CA mutant cells are not able to compensate for glucose withdrawal. Understanding the metabolic

Impact of KRAS, BRAF and PI3KCA mutations in rectal carcinomas treated with neoadjuvant radiochemotherapy and surgery

International Nuclear Information System (INIS)

Derbel, Olfa; La Fouchardière, Christelle de; Wang, Qing; Desseigne, Françoise; Rivoire, Michel; Meeus, Pierre; Peyrat, Patrice; Stella, Mattia; Martel-Lafay, Isabelle; Lemaistre, Anne-Isabelle

2013-01-01

Conventional treatment for locally advanced rectal cancer usually combines neoadjuvant radiochemotherapy and surgery. Until recently, there have been limited predictive factors (clinical or biological) for rectal tumor response to conventional treatment. KRAS, BRAF and PIK3CA mutations are commonly found in colon cancers. In this study, we aimed to determine the mutation frequencies of KRAS, BRAF and PIK3CA and to establish whether such mutations may be used as prognostic and/or predictive factors in rectal cancer patients. We retrospectively reviewed the clinical and biological data of 98 consecutive operated patients between May 2006 and September 2009. We focused in patients who received surgery in our center after radiochemotherapy and in which tumor samples were available. In the 98 patients with a rectal cancer, the median follow-up time was 28.3 months (4–74). Eight out of ninety-eight patients experienced a local recurrence (8%) and 17/98 developed distant metastasis (17%). KRAS, BRAF and PIK3CA were identified respectively in 23 (23.5%), 2 (2%) and 4 (4%) patients. As described in previous studies, mutations in KRAS and BRAF were mutually exclusive. No patient with local recurrence exhibited KRAS or PIK3CA mutation and one harbored BRAF mutation (12.5%). Of the seventeen patients with distant metastasis (17%), 5 were presenting KRAS mutation (29%), one BRAF (5%) and one PIK3CA mutation (5%). No relationship was seen between PIK3CA, KRAS or BRAF mutation and local or distant recurrences. The frequencies of KRAS, BRAF and PIK3CA mutations in our study were lower than the average frequencies reported in colorectal cancers and no significant correlation was found between local/distant recurrences and KRAS, BRAF or PIK3CA mutations. Future studies with greater number of patients, longer follow-up time and greater power to predict associations are necessary to fully understand this relationship

Evidence for $\\pi K$ -atoms with DIRAC-II

CERN Document Server

Allkofer, Yves

2008-01-01

DIRAC-II is a fixed-target experiment at the CERN Proton Synchroton (PS) which has been designed to search for piK atoms, a bound state of a pi±K± pair, and measure their lifetime. These atoms are observed through an excess of low energetic piK pairs over the background, detected in the two spectrometer arms. This excess comes from the ionization of piK atoms in the target and can be related to their mean life. The piK S-wave scattering length combination |a1/2 - a3/2| (for isospin 1/2 and 3/2) can be related to the latter. The aim of the upgraded DIRAC-II experiment is a measurement of the scattering length combination |a1/2 - a3/2| with a precision of 5%. piK atoms have not been observed so far. The original DIRAC experiment was designed to measure the scattering lengths of pipi atoms. So far, close to 15 000 atoms have been detected, leading to a precision on |a0 - a2| which is better than 10%. In chiral perturbation theories (ChPT) the pipi scattering lengths have been calculated with 2% precision a...

Narratives as Dialogic, Contested, and Aesthetic Performances

Science.gov (United States)

Harter, Lynn M.

2009-01-01

Dr. Pete Anderson, a clinician and professor at the University of Texas MD Anderson Cancer Center, entered the life of Anna and her family two years ago. Anna was referred to him because of his clinical research and expertise in pediatric oncology and multimodality therapies. Anna had been diagnosed with metastatic Ewing's Sarcoma, a form of bone…

“L’arte differente: MOCAK al MAXXI”. Mostra a cura di Anna Maria Potocka, Roma, MAXXI - Museo nazionale delle arti del XXI secolo, 7 dicembre 2016 – 22 gennaio 2017

Directory of Open Access Journals (Sweden)

Agnieszka Smigiel

2017-09-01

Full Text Available The paper presents a review of the exhibition entitled ”L’arte differente: MOCAK al MAXXI” hosted in the National Museum of 21st Century Arts in Rome between the 7th December 2016 and the 22nd January 2017. This art event is a part of the big MAXXI project, titled “Expanding the Horizon”. The aim is to present the collections from diverse institutions in order to give an opportunity to Italian and international visitors to come into direct contact with different cultural and artistic realities. The art exhibition is dedicated to the MOCAK collection (Museum of Contemporary Art in Krakow, which includes numerous works that show the history and actual status of contemporary art in Poland. As pointed out by the curator of the event and the Director of MOCAK, Anna Maria Potocka, it is not just a collection of works of art but rather of ideas.  This review describes several exhibited works and their accurate selection that reflects the curatorial strategy of the Cracovian museum.

Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival.

Science.gov (United States)

Lin, Zhiqiang; Zhou, Pingzhu; von Gise, Alexander; Gu, Fei; Ma, Qing; Chen, Jinghai; Guo, Haidong; van Gorp, Pim R R; Wang, Da-Zhi; Pu, William T

2015-01-02

Yes-associated protein (YAP), the nuclear effector of Hippo signaling, regulates cellular growth and survival in multiple organs, including the heart, by interacting with TEA (transcriptional enhancer activator)-domain sequence-specific DNA-binding proteins. Recent studies showed that YAP stimulates cardiomyocyte proliferation and survival. However, the direct transcriptional targets through which YAP exerts its effects are poorly defined. To identify direct YAP targets that mediate its mitogenic and antiapoptotic effects in the heart. We identified direct YAP targets by combining differential gene expression analysis in YAP gain- and loss-of-function with genome-wide identification of YAP-bound loci using chromatin immunoprecipitation and high throughput sequencing. This screen identified Pik3cb, encoding p110β, a catalytic subunit of phosphoinositol-3-kinase, as a candidate YAP effector that promotes cardiomyocyte proliferation and survival. YAP and TEA-domain occupied a conserved enhancer within the first intron of Pik3cb, and this enhancer drove YAP-dependent reporter gene expression. Yap gain- and loss-of-function studies indicated that YAP is necessary and sufficient to activate the phosphoinositol-3-kinase-Akt pathway. Like Yap, Pik3cb gain-of-function stimulated cardiomyocyte proliferation, and Pik3cb knockdown dampened YAP mitogenic activity. Reciprocally, impaired heart function in Yap loss-of-function was significantly rescued by adeno-associated virus-mediated Pik3cb expression. Pik3cb is a crucial direct target of YAP, through which the YAP activates phosphoinositol-3-kinase-AKT pathway and regulates cardiomyocyte proliferation and survival. © 2014 American Heart Association, Inc.

Technical evaluation report on the seven main transformer failures at the North Anna Power Station, Units 1 and 2 (Docket Nos. 50-338, 50-339)

International Nuclear Information System (INIS)

Dalton, K.J.; Kresser, J.V.; Savage, J.W.; Selan, J.C.

1984-01-01

This report documents technical evaluations on various aspects pertaining to the seven main transformer failures at the North Anna Power Station, Units 1 and 2. These reports cover the subjects of Probability Risk Assessment (PRA), Failure Modes and Effects Analysis (FMEA), Root Causes, Protection Systems, Modifications, Failure Statistics, and Generic Aspects. The PRA determined that the contribution from a main transformer failure affecting plant safety systems so as to increase the risk to the public health and safety is negligible. The FMEA determined that a main transformer failure can have primary and secondary effects on plant safety system operation. The evaluation of the Root Causes found that no single common cause contributed to the seven failures. Each failure was found to have specific circumstances for initiating the failure. Both the generator and transformer primary protection systems were found to perform correctly and were designed within industry standards and practices. The proposed modifications resulting from the analyses of the failures will improve system reliability and integrity, and will reduce potentially damaging effects. The failure statistic survey found very limited data bases from which a meaningful correlation could be ascertained. The statistical comparison found no appreciable anomalies with the NAPS failures. The evaluation of all the available information and the results of the separate reports on the main transformer failures found that several generic concerns exist

Nuclear Power 2010 Program Dominion Virginia Power Cooperative Project U.S. Department of Energy Cooperative Agreement DE-FC07-05ID14635 Construction and Operating License Demonstration Project Final Report

International Nuclear Information System (INIS)

Grecheck, Eugene S.; Batalo, David P.

2010-01-01

This report serves to summarize the major activities completed as part of Virginia Electric and Power Company's North Anna construction and operating license demonstration project with DOE. Project successes, lessons learned, and suggestions for improvement are discussed. Objectives of the North Anna COL project included preparation and submittal of a COLA to the USNRC incorporating ESBWR technology for a third unit a the North Anna Power Station site, support for the NRC review process and mandatory hearing, obtaining NRC approval of the COLA and issuance of a COL, and development of a business case necessary to support a decision on building a new nuclear power plant at the North Anna site.

Frequent alterations of the PI3K/AKT/mTOR pathways in hereditary nonpolyposis colorectal cancer

DEFF Research Database (Denmark)

Ekstrand, Anna Isinger; Jönsson, Mats; Lindblom, Annika

2010-01-01

The phosphatidylinositol 3-kinases-AKT-mammalian target of rapamycin pathway (PI3K/AKT/mTOR) is central in colorectal tumors. Data on its role in hereditary cancers are, however, scarce and we therefore characterized mutations in PIK3CA and KRAS, and expression of PIK3CA, phosphorylated AKT...... and PTEN in 58 HNPCC-associated colorectal cancers. Derangements of at least one of the PI3K/AKT/mTOR components analyzed were found in 51/58 (88%) tumors. Mutations in PIK3CA and KRAS were identified in 14 and 31% of the tumors respectively. Overexpression of PIK3CA and phosphorylated AKT occurred in 59...... and 75% and were strongly associated (P = 0.005). Reduced/lost PTEN expression was found in 63% of the tumors. Though HNPCC-associated colorectal cancers show simple genetic profiles with few chromosomal alterations, we demonstrate frequent and repeated targeting of the PI3K/AKT/mTOR pathway, which...

Nuclear Power 2010 Program Dominion Virginia Power Cooperative Project U.S. Department of Energy Cooperative Agreement DE-FC07-05ID14635 Construction and Operating License Demonstration Project Final Report

Energy Technology Data Exchange (ETDEWEB)

Eugene S. Grecheck

2010-11-30

This report serves to summarize the major activities completed as part of Virginia Electric and Power Company's North Anna construction and operating license demonstration project with DOE. Project successes, lessons learned, and suggestions for improvement are discussed. Objectives of the North Anna COL project included preparation and submittal of a COLA to the USNRC incorporating ESBWR technology for a third unit a the North Anna Power Station site, support for the NRC review process and mandatory hearing, obtaining NRC approval of the COLA and issuance of a COL, and development of a business case necessary to support a decision on building a new nuclear power plant at the North Anna site.

A mutant crp allele that differentially activates the operons of the fuc regulon in Escherichia coli.

Science.gov (United States)

Zhu, Y; Lin, E C

1988-05-01

L-Fucose is used by Escherichia coli through an inducible pathway mediated by a fucP-encoded permease, a fucI-encoded isomerase, a fucK-encoded kinase, and a fucA-encoded aldolase. The adolase catalyzes the formation of dihydroxyacetone phosphate and L-lactaldehyde. Anaerobically, lactaldehyde is converted by a fucO-encoded oxidoreductase to L-1,2-propanediol, which is excreted. The fuc genes belong to a regulon comprising four linked operons: fucO, fucA, fucPIK, and fucR. The positive regulator encoded by fucR responds to fuculose 1-phosphate as the effector. Mutants serially selected for aerobic growth on propanediol became constitutive in fucO and fucA [fucO(Con) fucA(Con)], but noninducible in fucPIK [fucPIK(Non)]. An external suppressor mutation that restored growth on fucose caused constitutive expression of fucPIK. Results from this study indicate that this suppressor mutation occurred in crp, which encodes the cyclic AMP-binding (or receptor) protein. When the suppressor allele (crp-201) was transduced into wild-type strains, the recipient became fucose negative and fucose sensitive (with glycerol as the carbon and energy source) because of impaired expression of fucA. The fucPIK operon became hyperinducible. The growth rate on maltose was significantly reduced, but growth on L-rhamnose, D-galactose, L-arabinose, glycerol, or glycerol 3-phosphate was close to normal. Lysogenization of fuc+ crp-201 cells by a lambda bacteriophage bearing crp+ restored normal growth ability on fucose. In contrast, lysogenization of [fucO(Con)fucA(Con)fucPIK(Non)crp-201] cells by the same phage retarded their growth on fucose.

Molecular Scree ning of Blast Resistance Genes in Rice Germplasms Resistant to Magnaporthe oryzae

Directory of Open Access Journals (Sweden)

Liang Yan

2017-01-01

Full Text Available Molecular screening of major rice blast resistance genes was determined with molecular markers, which showed close-set linkage to 11 major rice blast resistance genes (Pi-d2, Pi-z, Piz-t, Pi-9, Pi-36, Pi-37, Pi5, Pi-b, Pik-p, Pik-h and Pi-ta2, in a collection of 32 accessions resistant to Magnaporthe oryzae. Out of the 32 accessions, the Pi-d2 and Pi-z appeared to be omnipresent and gave positive express. As the second dominant, Pi-b and Piz-t gene frequencies were 96.9% and 87.5%. And Pik-h and Pik-p gene frequencies were 43.8% and 28.1%, respectively. The molecular marker linkage to Pi-ta2 produced positive bands in eleven accessions, while the molecular marker linkage to Pi-36 and Pi-37 in only three and four accessions, respectively. The natural field evaluation analysis showed that 30 of the 32 accessions were resistant, one was moderately resistant and one was susceptible. Infection types were negatively correlated with the genotype scores of Pi-9, Pi5, Pi-b, Pi-ta2 and Pik-p, although the correlation coefficients were very little. These results are useful in identification and incorporation of functional resistance genes from these germplasms into elite cultivars through marker-assisted selection for improved blast resistance in China and worldwide.

miR-203 inhibits cell proliferation and promotes cisplatin induced cell death in tongue squamous cancer

Energy Technology Data Exchange (ETDEWEB)

Lin, Jiong; Lin, Yao [Guangdong Provincial Key Laboratory of Stomatology, Department of Orthodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, 510055 (China); Fan, Li [Department of Pharmaceutical Analysis, School of Pharmacy, The Fourth Military Medical University, Xi' an, Shaanxi, 710032 (China); Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, 510055 (China); Kuang, Wei [Department of Stomatology, Guangzhou General Hospital of Guangzhou Military Command, 111 Liuhua Road, Guangzhou, 510010 (China); Zheng, Liwei [State Key Laboratory of Oral Diseases, Sichuan University, Wuhou District, Chengdu, 610041 (China); Wu, Jiahua [Guangdong Provincial Key Laboratory of Stomatology, Department of Orthodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, 510055 (China); Shang, Peng [Patient-specific Orthopedic Technology Research Center in GuangDong Research Centre for Neural Engineering, 1068 Xueyuan Boulevard, University Town of Shenzhen, Xili, Nanshan, Shenzhen, 518055 (China); Wang, Qiaofeng [Department of Pharmaceutical Chemistry, School of Pharmacy, The Fourth Military Medical University, Xi' an, Shanxi, 710032 (China); Tan, Jiali, E-mail: jasminenov@163.com [Guangdong Provincial Key Laboratory of Stomatology, Department of Orthodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, 510055 (China)

2016-04-29

Oral squamous cell carcinoma (OSCC) is one of the most common types of the head and neck cancer. Chemo resistance of OSCC has been identified as a substantial therapeutic hurdle. In this study, we analyzed the role of miR-203 in the OSCC and its effects on cisplatin-induced cell death in an OSCC cell line, Tca8113. There was a significant decrease of miR-203 expression in OSCC samples, compared with the adjacent normal, non-cancerous tissue. After 3 days cisplatin treatment, the survived Tca8113 cells had a lower expression of miR-203 than that in the untreated control group. In contrast, PIK3CA showed an inverse expression in cancer and cisplatin survived Tca8113 cells. Transfection of Tca8113 cells with miR-203 mimics greatly reduced PIK3CA expression and Akt activation. Furthermore, miR-203 repressed PIK3CA expression through targeting the 3′UTR. Restoration of miR-203 not only suppressed cell proliferation, but also sensitized cells to cisplatin induced cell apoptosis. This effect was absent in cells that were simultaneously treated with PIK3CA RNAi. In summary, these findings suggest miR-203 plays an important role in cisplatin resistance in OSCC, and furthermore delivery of miR-203 analogs may serve as an adjuvant therapy for OSCC. - Highlights: • Much lower miR-203 expression in cisplatin resistant Tca8113 cells is discovered. • Delivery of miR-203 can sensitize the Tca8113 cells to cisplatin induced cell death. • MiR-203 can downregulate PIK3CA through the 3′UTR. • The effects of miR-203 on cisplatin sensitivity is mainly through PIK3CA pathway.

Biohuumus - looduslik, kuid tõhus lahendus mullaviljakuse tõstmiseks / Nadezda Knjazeva

Index Scriptorium Estoniae

Knjazeva, Nadezda

2010-01-01

Biohuumus "Green-PIK" on orgaaniliste jääkide tehnoloogiliste vihmaussidega "Staratel" ümbertöötlemise produkt. See kontsentreeritud väetis sisaldab tasakaalustatud kombinatsioonis tervet kompleksi vajalikke toitaineid ja mikroelemente, fermente, pinnasantibiootikume, vitamiine, taimede kasvu ja arengu hormoone. Väetamine muutub efektiivsemaks biohuumuse ja vedela kontsentraadi Gumistar "Grin-PIK" kompleksse kasutamise korral

Ablation of phosphoinositide-3-kinase class II alpha suppresses hepatoma cell proliferation

Energy Technology Data Exchange (ETDEWEB)

Ng, Stanley K.L. [Singapore Immunology Network A-STAR (Singapore); Neo, Soek-Ying, E-mail: neo_soek_ying@sics.a-star.edu.sg [Singapore Immunology Network A-STAR (Singapore); Yap, Yann-Wan [Singapore Immunology Network A-STAR (Singapore); Karuturi, R. Krishna Murthy; Loh, Evelyn S.L. [Genome Institute of Singapore A-STAR (Singapore); Liau, Kui-Hin [Department of General Surgery, Tan Tock Seng Hospital (Singapore); Ren, Ee-Chee, E-mail: ren_ee_chee@immunol.a-star.edu.sg [Singapore Immunology Network A-STAR (Singapore); Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore (Singapore)

2009-09-18

Cancer such as hepatocellular carcinoma (HCC) is characterized by complex perturbations in multiple signaling pathways, including the phosphoinositide-3-kinase (PI3K/AKT) pathways. Herein we investigated the role of PI3K catalytic isoforms, particularly class II isoforms in HCC proliferation. Among the siRNAs tested against the eight known catalytic PI3K isoforms, specific ablation of class II PI3K alpha (PIK3C2{alpha}) was the most effective in impairing cell growth and this was accompanied by concomitant decrease in PIK3C2{alpha} mRNA and protein levels. Colony formation ability of cells deficient for PIK3C2{alpha} was markedly reduced and growth arrest was associated with increased caspase 3 levels. A small but significant difference in gene dosage and expression levels was detected between tumor and non-tumor tissues in a cohort of 19 HCC patients. Taken together, these data suggest for the first time that in addition to class I PI3Ks in cancer, class II PIK3C2{alpha} can modulate HCC cell growth.

Anna Mouglalis kõikide vastu / Anna Mouglalis ; intervjueerinud Guillermo Espinosa

Index Scriptorium Estoniae

Mouglalis, Anna

2010-01-01

Prantsuse moekunstniku Coco Chaneli ja vene helilooja Igor Stravinki armuloost rääkivas filmis "Coco Chanel & Igor Stravinski" mängib peaosa Chaneli moemaja modell ja reklaaminägu. Intervjuus endast ja oma rollidest

Neuromuscular control of wingbeat kinematics in Anna's hummingbirds (Calypte anna).

Science.gov (United States)

Altshuler, Douglas L; Welch, Kenneth C; Cho, Brian H; Welch, Danny B; Lin, Amy F; Dickson, William B; Dickinson, Michael H

2010-07-15

Hummingbirds can maintain the highest wingbeat frequencies of any flying vertebrate - a feat accomplished by the large pectoral muscles that power the wing strokes. An unusual feature of these muscles is that they are activated by one or a few spikes per cycle as revealed by electromyogram recordings (EMGs). The relatively simple nature of this activation pattern provides an opportunity to understand how motor units are recruited to modulate limb kinematics. Hummingbirds made to fly in low-density air responded by moderately increasing wingbeat frequency and substantially increasing the wing stroke amplitude as compared with flight in normal air. There was little change in the number of spikes per EMG burst in the pectoralis major muscle between flight in normal and low-density heliox (mean=1.4 spikes cycle(-1)). However the spike amplitude, which we take to be an indication of the number of active motor units, increased in concert with the wing stroke amplitude, 1.7 times the value in air. We also challenged the hummingbirds using transient load lifting to elicit maximum burst performance. During maximum load lifting, both wing stroke amplitude and wingbeat frequency increased substantially above those values during hovering flight. The number of spikes per EMG burst increased to a mean of 3.3 per cycle, and the maximum spike amplitude increased to approximately 1.6 times those values during flight in heliox. These results suggest that hummingbirds recruit additional motor units (spatial recruitment) to regulate wing stroke amplitude but that temporal recruitment is also required to maintain maximum stroke amplitude at the highest wingbeat frequencies.

Untitled

African Journals Online (AJOL)

roles, power imbalances, cultural norms presence of few products and ... contraceptive methods was the lowest prevent unwanted pregnancy. Studies among women in the age .... 13) Anna G, Lora Green, Anna F. G.. Teenagers' knowledge of.

Ultrasonic Phased Array Assessment of the Interference Fit and Leak Path of the North Anna Unit 2 Control Rod Drive Mechanism Nozzle 63 with Destructive Validation

Energy Technology Data Exchange (ETDEWEB)

Crawford, Susan L.; Cinson, Anthony D.; MacFarlan, Paul J.; Hanson, Brady D.; Mathews, Royce

2012-08-01

The objective of this investigation was to evaluate the efficacy of ultrasonic testing (UT) for primary water leak path assessments of reactor pressure vessel (RPV) upper head penetrations. Operating reactors have experienced leakage when stress corrosion cracking of nickel-based alloy penetrations allowed primary water into the annulus of the interference fit between the penetration and the low-alloy steel RPV head. In this investigation, UT leak path data were acquired for an Alloy 600 control rod drive mechanism nozzle penetration, referred to as Nozzle 63, which was removed from the North Anna Unit 2 reactor when the RPV head was replaced in 2002. In-service inspection prior to the head replacement indicated that Nozzle 63 had a probable leakage path through the interference fit region. Nozzle 63 was examined using a phased-array UT probe with a 5.0-MHz, eight-element annular array. Immersion data were acquired from the nozzle inner diameter surface. The UT data were interpreted by comparing to responses measured on a mockup penetration with known features. Following acquisition of the UT data, Nozzle 63 was destructively examined to determine if the features identified in the UT examination, including leakage paths and crystalline boric acid deposits, could be visually confirmed. Additional measurements of boric acid deposit thickness and low-alloy steel wastage were made to assess how these factors affect the UT response. The implications of these findings for interpreting UT leak path data are described.

Seryozha's Education

Science.gov (United States)

Blaisdell, Bob

2015-01-01

This is discussion of one of Leo Tolstoy's fictional dramatisations of aggressive but dull-witted pedagogy. In "Anna Karenina," two adults badger a lively, deep-souled, active-minded boy, Anna's son Seryozha, to learn his rote-lessons.

Eesti päritolu naine tõmbab meediaäri niite / Priit Pullerits

Index Scriptorium Estoniae

Pullerits, Priit, 1965-

2005-01-01

Meediamagnaat Rupert Murdochi eestlasest eksnaine Anna Murdoch Mann on välismeedia andmetel astunud otsustavaid samme, et kindlustada oma laste tulevane osalemine News Corporationi juhtimises. Lachlan Murdoch, Anna ja Rupert Murdochi vanem poeg on lahkunud ettevõtte juhtkonnast

Prediction of Response to Therapy and Clinical Outcome through a Pilot Study of Complete Genetic Assessment of Ovarian Cancer

Science.gov (United States)

2015-12-01

B, PIK3CA, BRCA2, ATM, SETD2, ATRX, MTOR, PIK3R1 Mucinous KRAS, TP53, CDKN2A, SMAD4 , TERT Carcinosarcoma TP53, RB1, APC Granulasa cell ATM...alterations in the PTEN- PI3K- AKT -mTOR pathway in a cohort of 379 ovarian cancer patients. Submitted to American Society of Clinical Oncology Annual meeting

Predictive role of multiple gene alterations in response to cetuximab in metastatic colorectal cancer: A single center study

Directory of Open Access Journals (Sweden)

Ulivi Paola

2012-05-01

Full Text Available Abstract Background KRAS mutations negatively affect outcome after treatment with cetuximab in metastatic colorectal cancer (mCRC patients. As only 20% of KRAS wild type (WT patients respond to cetuximab it is possible that other mutations, constitutively activating the EGFR pathway, are present in the non-responding KRAS WT patients. We retrospectively analyzed objective tumor response rate, (ORR progression-free (PFS and overall survival (OS with respect to the mutational status of KRAS, BRAF, PIK3CA and PTEN expression in mCRC patients treated with a cetuximab-based regimen. Methods 67 mCRC patients were enrolled onto the study. DNA was extracted from paraffin-embedded sections derived from primary or metastatic lesions. Exon 2 of KRAS and exon 15 of BRAF were analyzed by direct sequencing, PIK3CA was evaluated by pyrosequencing and PTEN expression by immunohistochemistry. Results BRAF and PIK3CA mutations were independently associated with worse PFS (p = 0.006 and p = 0.028, respectively and OS (p = 0.008 and p = 0.029, respectively. No differences in clinical outcome were found between patients who were positive or negative for PTEN expression. Conversely, patients negative for KRAS, BRAF and PIK3CA mutations were characterized by significantly better ORR, PFS and OS than patients with at least one of these mutations. Conclusions BRAF and PIK3CA mutations would seem to be independent predictors of anti-EGFR therapy effectiveness and could be taken into consideration during treatment decision making.

Fredericus Anna Jentink

NARCIS (Netherlands)

NN,

1913-01-01

By his decease the Leyden Museum of Natural History has lost a Director, who during nearly thirty years has given all his energy to this Institution, has tried to extend and to complete its collections and to bring its internal arrangement more in agreement with modern views. In the first years of

Anna Abridges "Masha."

Science.gov (United States)

Crago, Hugh

1989-01-01

Examines a young girl's abridgment of Mara Kay's novel "Masha," focusing on the selection processes she used. Suggests that text selected for the abridgment had personal significance, while less significant or negative text was omitted. Concludes that the experience gave shape and meaning to the girl's own growing up. (MM)

Prospective Biomarker Analysis of the Randomized CHER-LOB Study Evaluating the Dual Anti-HER2 Treatment With Trastuzumab and Lapatinib Plus Chemotherapy as Neoadjuvant Therapy for HER2-Positive Breast Cancer.

Science.gov (United States)

Guarneri, Valentina; Dieci, Maria Vittoria; Frassoldati, Antonio; Maiorana, Antonino; Ficarra, Guido; Bettelli, Stefania; Tagliafico, Enrico; Bicciato, Silvio; Generali, Daniele Giulio; Cagossi, Katia; Bisagni, Giancarlo; Sarti, Samanta; Musolino, Antonino; Ellis, Catherine; Crescenzo, Rocco; Conte, PierFranco

2015-09-01

The CHER-LOB randomized phase II study showed that the combination of lapatinib and trastuzumab plus chemotherapy increases the pathologic complete remission (pCR) rate compared with chemotherapy plus either trastuzumab or lapatinib. A biomarker program was prospectively planned to identify potential predictors of sensitivity to different treatments and to evaluate treatment effect on tumor biomarkers. Overall, 121 breast cancer patients positive for human epidermal growth factor 2 (HER2) were randomly assigned to neoadjuvant chemotherapy plus trastuzumab, lapatinib, or both trastuzumab and lapatinib. Pre- and post-treatment samples were centrally evaluated for HER2, p95-HER2, phosphorylated AKT (pAKT), phosphatase and tensin homolog, Ki67, apoptosis, and PIK3CA mutations. Fresh-frozen tissue samples were collected for genomic analyses. A mutation in PIK3CA exon 20 or 9 was documented in 20% of cases. Overall, the pCR rates were similar in PIK3CA wild-type and PIK3CA-mutated patients (33.3% vs. 22.7%; p = .323). For patients receiving trastuzumab plus lapatinib, the probability of pCR was higher in PIK3CA wild-type tumors (48.4% vs. 12.5%; p = .06). Ki67, pAKT, and apoptosis measured on the residual disease were significantly reduced from baseline. The degree of Ki67 inhibition was significantly higher in patients receiving the dual anti-HER2 blockade. The integrated analysis of gene expression and copy number data demonstrated that a 50-gene signature specifically predicted the lapatinib-induced pCR. PIK3CA mutations seem to identify patients who are less likely to benefit from dual anti-HER2 inhibition. p95-HER2 and markers of phosphoinositide 3-kinase pathway deregulation are not confirmed as markers of different sensitivity to trastuzumab or lapatinib. HER2 is currently the only validated marker to select breast cancer patients for anti-HER2 treatment; however, it is becoming evident that HER2-positive breast cancer is a heterogeneous disease. In addition, more

Comparison of Akt/mTOR/4E-BP1 pathway signal activation and mutations of PIK3CA in Merkel cell polyomavirus-positive and Merkel cell polyomavirus-negative carcinomas.

Science.gov (United States)

Iwasaki, Takeshi; Matsushita, Michiko; Nonaka, Daisuke; Kuwamoto, Satoshi; Kato, Masako; Murakami, Ichiro; Nagata, Keiko; Nakajima, Hideki; Sano, Shigetoshi; Hayashi, Kazuhiko

2015-02-01

Merkel cell polyomavirus (MCPyV) integrates monoclonally into the genomes of approximately 80% of Merkel cell carcinomas (MCCs), affecting their clinicopathological features. The molecular mechanisms underlying MCC development after MCPyV infection remain unclear. We investigated the association of MCPyV infection with activation of the Akt/mammalian target of rapamycin (mTOR)/4E-binding protein 1 (4E-BP1) signaling pathway in MCCs to elucidate the role of these signal transductions and to identify molecular targets for treatment. We analyzed the molecular and pathological characteristics of 41 MCPyV-positive and 27 MCPyV-negative MCCs. Expression of mTOR, TSC1, and TSC2 messenger RNA was significantly higher in MCPyV-negative MCCs, and Akt (T308) phosphorylation also was significantly higher (92% vs 66%; P = .019), whereas 4E-BP1 (S65 and T70) phosphorylation was common in both MCC types (92%-100%). The expression rates of most other tested signals were high (60%-100%) and not significantly correlated with MCPyV large T antigen expression. PIK3CA mutations were observed more frequently in MCPyV-positive MCCs (6/36 [17%] vs 2/20 [10%]). These results suggest that protein expression (activation) of most Akt/mTOR/4E-BP1 pathway signals was not significantly different in MCPyV-positive and MCPyV-negative MCCs, although these 2 types may differ in tumorigenesis, and MCPyV-negative MCCs showed significantly more frequent p-Akt (T308) activation. Therefore, certain Akt/mTOR/4E-BP1 pathway signals could be novel therapeutic targets for MCC regardless of MCPyV infection status. Copyright © 2015 Elsevier Inc. All rights reserved.

На сцене сойдутся Восток и Запад / Лилия Крысина

Index Scriptorium Estoniae

Крысина, Лилия

2010-01-01

Koreograafid-tantsijad Külli Roosna ja Anna esitavad Tallinnas ja Tartus oma soolo-tantsuetenduse, milles ühinevad Ida ja Lääs. Läänt esindab Külli Roosna (Eesti) "Circle Through" ja Ida esindab Anna (Jaapan) "Busu". Organisaatoriks on Sõltumatu Tantsu Ühendus

Aeg on inimeste kanda / Sirje Semm

Index Scriptorium Estoniae

Semm, Sirje, 1950-

2009-01-01

5. septembril meenutati Anna kirikus koos kihelkonna rahvaga aja kulgu ja lugu. Täpselt 325 aastat tagasi, 5. septembril 1684. aastal sai Anna kogudusest iseseisev kogudus. Seda sündmust tähistati piduliku kontsert-jumalateenistusega. Avati ülevaatenäitus kihelkonna ja koguduse ajaloost.

Dietary protein level affects iridescent coloration in Anna's hummingbirds, Calypte anna

OpenAIRE

Meadows, Melissa G.; Roudybush, Thomas E.; McGraw, Kevin J.

2012-01-01

Many animal displays involve colorful ornamental traits that signal an individual's quality as a mate or rival. Brilliant iridescent ornaments are common, but little is currently known about their production cost and signaling value. One potential cost of colorful ornaments is the acquisition of limited dietary resources that may be involved, directly or indirectly, in their production. Protein, the primary component of bird feathers and of many nanostructural components of iridescent traits,...

78 FR 70163 - Communication of Operational Information between Natural Gas Pipelines and Electric Transmission...

Science.gov (United States)

2013-11-22

... Street NE., Washington, DC 20426, (202) 502-8931, [email protected] . Anna Fernandez (Legal Information), Office of the General Counsel, 888 First Street NE., Washington, DC 20426, (202) 502-6682, anna.... Questions Posed by the Commission 100. A. Generator to Electric Transmission Operator 100. Communications 1...

77 FR 46119 - Notice of Inventory Completion: U.S. Department of the Interior, Bureau of Indian Affairs...

Science.gov (United States)

2012-08-02

... be culturally affiliated with the human remains should contact Anna Pardo, Museum Program Manager... culturally affiliated with the human remains may contact the U.S. Department of the Interior, Bureau of... Affairs at the address below by September 4, 2012. ADDRESSES: Anna Pardo, Museum Program Manager/NAGPRA...

Semi-inner-products in Banach Spaces with Applications to Regularized Learning, Sampling, and Sparse Approximation

Science.gov (United States)

2016-03-13

7.00 8.00 Praveen K. Yenduri, Anna C. Gilbert, Jun Zhang. Integrate-and-fire neuron modeled as a low-rate sparse time-encoding device, 2012 Third...International Conference on Intelligent Control and Information Processing (ICICIP). 15-JUL- 12, Dalian, China. : , Praveen K. Yenduri, Anna C. Gilbert

Lexical borrowing by Khoekhoegowab from Cape Dutch and Afrikaans

Directory of Open Access Journals (Sweden)

Wilfrid Haacke

2015-02-01

Full Text Available The present article instantiates types of lexical borrowing from Afrikaans and Dutch in Namibian Khoekhoegowab (also known as “Nama”/“Damara”, but occasionally also refers to borrowings in the opposite direction. Where evidence allows, loans are traced back beyond Afrikaans to the era of Cape Dutch and contemporary interethnic contacts. Various categories ranging from adoptions to phonologically integrated loans, hybrids and calques are presented and, where possible, historical inferences are offered. The high degree of translational equivalence between Khoekhoe serial verbs and Afrikaans compound verbs leads to the consideration of some grammatical aspects including replication and relexification. Finally, reference is made to a parallel between Afrikaans and “Khoekhoe Afrikaans” syntax pointed out by den Besten (2013: Afrikaans circumlocutions like ek / sy wat Anna is (Khoekhoe: Anna.ta / Anna.s are literal equivalents of the underlying phrasal structures of Khoekhoe surface nouns #stem.pgn# in first, second or third person, as accounted for by the “desentential hypothesis” (Haacke 2006.  

Clinical holistic medicine: the case story of Anna. I. Long-term effect of childhood sexual abuse and incest with a treatment approach.

Science.gov (United States)

Ventegodt, Søren; Clausen, Birgitte; Merrick, Joav

2006-02-02

The nervous breakdown of a 22-year-old, young woman was caused by severe sexual abuse in childhood, which was repressed over many years. During therapy, the patient accumulated resources to start the painful integration of these old traumas. Using holistic existential therapy in accordance with the life mission theory and the holistic process theory of healing, she finally was able to confront her old traumas and heal her existence. She seemingly recovered completely (including regaining full emotional range) through holistic existential therapy, individually and in a group. The therapy took 18 months and more than 100 hours of intensive therapy. In the beginning of the therapy, the issues were her physical and mental health; in the middle of the therapy, the central issue was her purpose of life and her love life; and at the conclusion of the therapy, the issue was gender and sexuality. The strategy was to build up her strength for several months, mobilizing hidden resources and motivation for living, before the old traumas could be confronted and integrated. The therapy was based on quality of life philosophy, on the life mission theory, the theory of ego, the theory of talent, the theory of the evil side of man, the theory of human character, and the holistic process theory of healing. The clinical procedures included conversation, philosophical training, group therapeutic tools, extended use of therapeutic touch, holistic pelvic examination, and acceptance through touch was used to integrate the early traumas bound to the pelvis and scar tissue in the sexual organs. She was processed according to 10 levels of the advanced toolbox for holistic medicine and the general plan for clinical holistic psychiatry. The emotional steps she went through are well described by the scale of existential responsibility. The case story of Anna is an example of how even the most severely ill patient can recover fully with the support of holistic medical treatment, making her feel

Clinical Holistic Medicine: The Case Story of Anna. I. Long-Term Effect of Childhood Sexual Abuse and Incest with a Treatment Approach

Science.gov (United States)

Ventegodt, Søren; Clausen, Birgitte; Merrick, Joav

2006-01-01

The nervous breakdown of a 22-year-old, young woman was caused by severe sexual abuse in childhood, which was repressed over many years. During therapy, the patient accumulated resources to start the painful integration of these old traumas. Using holistic existential therapy in accordance with the life mission theory and the holistic process theory of healing, she finally was able to confront her old traumas and heal her existence. She seemingly recovered completely (including regaining full emotional range) through holistic existential therapy, individually and in a group. The therapy took 18 months and more than 100 hours of intensive therapy. In the beginning of the therapy, the issues were her physical and mental health; in the middle of the therapy, the central issue was her purpose of life and her love life; and at the conclusion of the therapy, the issue was gender and sexuality. The strategy was to build up her strength for several months, mobilizing hidden resources and motivation for living, before the old traumas could be confronted and integrated. The therapy was based on quality of life philosophy, on the life mission theory, the theory of ego, the theory of talent, the theory of the evil side of man, the theory of human character, and the holistic process theory of healing. The clinical procedures included conversation, philosophical training, group therapeutic tools, extended use of therapeutic touch, holistic pelvic examination, and acceptance through touch was used to integrate the early traumas bound to the pelvis and scar tissue in the sexual organs. She was processed according to 10 levels of the advanced toolbox for holistic medicine and the general plan for clinical holistic psychiatry. The emotional steps she went through are well described by the scale of existential responsibility. The case story of Anna is an example of how even the most severely ill patient can recover fully with the support of holistic medical treatment, making her feel

Clinical Holistic Medicine: The Case Story of Anna. I. Long-Term Effect of Childhood Sexual Abuse and Incest with a Treatment Approach

Directory of Open Access Journals (Sweden)

Søren Ventegodt

2006-01-01

Full Text Available The nervous breakdown of a 22-year-old, young woman was caused by severe sexual abuse in childhood, which was repressed over many years. During therapy, the patient accumulated resources to start the painful integration of these old traumas. Using holistic existential therapy in accordance with the life mission theory and the holistic process theory of healing, she finally was able to confront her old traumas and heal her existence. She seemingly recovered completely (including regaining full emotional range through holistic existential therapy, individually and in a group. The therapy took 18 months and more than 100 hours of intensive therapy. In the beginning of the therapy, the issues were her physical and mental health; in the middle of the therapy, the central issue was her purpose of life and her love life; and at the conclusion of the therapy, the issue was gender and sexuality. The strategy was to build up her strength for several months, mobilizing hidden resources and motivation for living, before the old traumas could be confronted and integrated. The therapy was based on quality of life philosophy, on the life mission theory, the theory of ego, the theory of talent, the theory of the evil side of man, the theory of human character, and the holistic process theory of healing. The clinical procedures included conversation, philosophical training, group therapeutic tools, extended use of therapeutic touch, holistic pelvic examination, and acceptance through touch was used to integrate the early traumas bound to the pelvis and scar tissue in the sexual organs. She was processed according to 10 levels of the advanced toolbox for holistic medicine and the general plan for clinical holistic psychiatry. The emotional steps she went through are well described by the scale of existential responsibility. The case story of Anna is an example of how even the most severely ill patient can recover fully with the support of holistic medical

Eestlanna, jaapanlanna ja tantsivad kehad / Keiu Virro

Index Scriptorium Estoniae

Virro, Keiu, 1987-

2010-01-01

Koreograafid-tantsijad Külli Roosna ja Anna esitavad Tallinnas Kanuti Gildi saalis ja Tartus Genialistide klubis oma soolo-tantsuetenduse, milles ühinevad Ida ja Lääs. Läänt esindab Külli Roosna (Eesti) "Circle Through" ja Ida esindab Anna (Jaapan) "Busu". Organisaatoriks on Sõltumatu Tantsu Ühendus

The Effectiveness of Cognitive Reflection and Re-structurization on Career Decision Making of High School Students

Directory of Open Access Journals (Sweden)

Wagimin Wagimin

2015-03-01

Key Words: career decision making, CIP model, reflection, cognitive restructuring Abstrak: Penelitian ini bertujuan untuk menguji keefektifan  refleksi dan penstrukturan ulang kognitif guna meningkatkan pengambilan keputusan karier siswa SMA berdasarkan model PIK. Penelitian eksperimen ini menggunakan rancangan RCTs, dan subjek 40 orang siswa sebagai kelompok eksperi-men dan 40 sebagai kelompok kontrol. Sub-kemampuan pengambilan keputusan karier model PIK yang dikembangkan meliputi: memahami diri, memahami pilihan pekerjaan, komunikasi, analisis, sinte-sis, penilaian, pelaksanaan, dan proses pelaksanaan. Hasil penelitian menunjukkan bahwa ada perbeda-an kemampuan pengambilan keputusan karier antara siswa kelompok eksperimen dan kelompok kon-trol di mana kelompok eksperimen memiliki nilai rata-rata yang lebih tinggi. Informasi controlled trials menguatkan juga bahwa refleksi dan penstrukturan ulang kognitif  efektif untuk  meningkatkan kemampuan pengambilan keputusan karier siswa SMA. Kata kunci: pengambilan keputusan karier, model PIK, refleksi, penstrukturan ulang kognitif

Ühe suve akvarellid / Evelin Samuel ja Liina Hergauk

Index Scriptorium Estoniae

Samuel, Evelin, 1975-

2015-01-01

Roosanupuline kampsun, idee ja teostus Evelin Samuel. Vanaroosa pluus ja barett, idee ja teostus Ruta Tännav. Mohäärlõngast topp, idee ja teostus Anna Verschik. Linane topp, idee ja teostus Liina Hergauk. Pitsmustritega mohäärkleit, idee ja teostus Ruta Tännav. Puuvillane topp, idee ja teostus Anna Verschik

Take action: influence diversity.

Science.gov (United States)

Gomez, Norma J

2013-01-01

Increased diversity brings strength to nursing and ANNA. Being a more diverse association will require all of us working together. There is an old proverb that says: "one hand cannot cover the sky; it takes many hands." ANNA needs every one of its members to be a part of the diversity initiative.

PI3K pathway activation results in low efficacy of both trastuzumab and lapatinib

International Nuclear Information System (INIS)

Wang, Leiping; Hu, Xichun; Zhang, Qunling; Zhang, Jian; Sun, Si; Guo, Haiyi; Jia, Zhen; Wang, Biyun; Shao, Zhimin; Wang, Zhonghua

2011-01-01

Human epidermal growth factor receptor 2 (HER2) is the most crucial ErbB receptor tyrosine kinase (RTK) family member in HER2-positive (refered to HER2-overexpressing) breast cancer which are dependent on or 'addictive' to the Phosphatidylinositol-3-kinase (PI3K) pathway. HER2-related target drugs trastuzumab and lapatinib have been the foundation of treatment of HER2--positive breast cancer. This study was designed to explore the relationship between PI3K pathway activation and the sensitivity to lapatinib in HER2--positive metastatic breast cancer patients pretreated with anthracyclins, taxanes and trastuzumab. Sixty-seven HER2-positive metastatic breast cancer patients were recruited into a global lapatinib Expanded Access Program and 57 patients have primary tumor specimens available for determination of PI3K pathway status. PTEN status was determined by immunohistochemical staining and PIK3CA mutations were detected via PCR sequencing. All patients were treated with lapatinib 1250 mg/day continuously and capecitabine 1000 mg/m 2 twice daily on a 2-week-on and 1-week-off schedule until disease progression, death, withdrawal of informed consent, or intolerable toxicity. PIK3CA mutations and PTEN loss were detected in 12.3% (7/57) and 31.6% (18/57) of the patients, respectively. Twenty-two patients with PI3K pathway activation (defined as PIK3CA mutation and/or PTEN expression loss) had a lower clinical benefit rate (36.4% versus 68.6%, P = 0.017) and a lower overall response rate (9.1% versus 31.4%, P = 0.05), when compared with the 35 patients with no activation. A retrospective analysis of first trastuzumab-containing regimen treatment data showed that PI3K pathway activation correlated with a shorter median progression-free survival (4.5 versus 9.0 months, P = 0.013). PIK3CA mutations occur more frequently in elder patients for HER2-positive breast cancer. PIK3CA mutations and PTEN loss are not mutually exclusive. PI3K pathway activation resulting

LHCb: Observation of CP violation in $B^{\\pm} \\to DK^{\\pm}$ decays at LHCb

CERN Multimedia

Gandini, Paolo

2012-01-01

An analysis of $B^+ \\to DK^+$ and $B^+ \\to D\\pi^+$ decays is presented where the D meson is reconstructed in the two-body final states: $K^+\\pi-, K^+K^-, \\pi^+\\pi^-$ and $\\pi^+K^-$. Using 1.0 fb$^{-1}$ of LHCb data, measurements of several observables are made including the first observation of the suppressed mode $B^+ \\to DK^+, D \\to \\pi^+K^-$. CP violation in $B^+ \\to DK^+$ decays is observed with 5.8 $\\sigma$ significance.

Sarah Schulman’s Empathy, Ties that Bind, and the Possibilities of the Stranger

Directory of Open Access Journals (Sweden)

Amy Tziporah Karp

2017-09-01

Full Text Available In her novel 'Empathy' (1992, Sarah Schulman imagines what it means to be caught between the assimilation of Ashkenazi Jewish Americans and the otherness of Eastern Europe. Schulman’s protagonist Anna O. traverses many landscapes and, unlike other characters in the novel that work to transcend their stranger identity, Anna O. makes a new life for herself through negotiating what I will call a liminal identity. For Schulman, the task of illuminating the stranger condition that her main character inhabits is a tricky one. While characters of earlier Jewish American texts by writers such as Anzia Yezierska were readily understood as strangers working towards ‘becoming American’, it is implicitly accepted that Anna O., living in queer 1990s New York City, is already a completely assimilated American. Schulman uses a variety of narrative strategies that culminate in a somewhat messy palimpsest attempting to convey the nuanced experience of the stranger. The resulting textual fragmentation removes any stable point of reference so that scholars and readers of 'Empathy' must reconstruct various narrative elements in trying to make sense of Anna O.’s world. One is left to consult volumes of critical work that hardly get to the heart of Anna O.’s Jewish queer experience, to piece them together into a patchwork that may, by its end, accomplish the task of excavating Schulman’s postmodern stranger. In this article I argue that inhabiting the position of the stranger allows Anna O. the possibility of creating some sort of coexistence between, and cohabitation of, her queer and Jewish identities. In this way, Schulman constructs the stranger as a subject position replete with possibility rather than as a liability that must be shed in order to acculturate onself to American life.

Molecular characterization of apocrine salivary duct carcinoma.

Science.gov (United States)

Chiosea, Simion I; Williams, Lindsay; Griffith, Christopher C; Thompson, Lester D R; Weinreb, Ilan; Bauman, Julie E; Luvison, Alyssa; Roy, Somak; Seethala, Raja R; Nikiforova, Marina N

2015-06-01

Contemporary classification and treatment of salivary duct carcinoma (SDC) require its thorough molecular characterization. Thirty apocrine SDCs were analyzed by the Ion Ampliseq Cancer HotSpot panel v2 for mutations in 50 cancer-related genes. Mutational findings were corroborated by immunohistochemistry (eg, TP53, BRAF, β-catenin, estrogen, and androgen receptors) or Sanger sequencing/SNaPshot polymerase chain reaction. ERBB2 (HER2), PTEN, FGFR1, CDKN2A/P16, CMET, EGFR, MDM2, and PIK3CA copy number changes were studied by fluorescence in situ hybridization. TP53 mutations (15/27, 56%), PTEN loss (11/29, 38%, including 2 cases with PTEN mutation), PIK3CA hotspot mutations (10/30, 33%), HRAS hotspot mutations (10/29; 34%), and ERBB2 amplification (9/29, 31%, including 1 case with mutation) represented the 5 most common abnormalities. There was no correlation between genetic changes and clinicopathologic parameters. There was substantial overlap between genetic changes: 8 of 9 cases with ERBB2 amplification also harbored a PIK3CA, HRAS, and TP53 mutation and/or PTEN loss. Six of 10 cases with PIK3CA mutation also had an HRAS mutation. These findings provide a molecular rationale for dual targeting of mitogen-activated protein kinase and phosphoinositide 3-kinase pathways in SDC. FGFR1 amplification (3/29, 10%) represents a new potential target. On the basis of studies of breast carcinomas, the efficacy of anti-ERBB2 therapy will likely be decreased in SDC with ERBB2 amplification co-occurring with PIK3CA mutation or PTEN loss. Therefore, isolated ERBB2 testing is insufficient for theranostic stratification of apocrine SDC. On the basis of the prevalence and type of genetic changes, apocrine SDC appears to resemble one subtype of breast carcinoma-"luminal androgen receptor positive/molecular apocrine."

Tartu kevad / Juta Kivimäe

Index Scriptorium Estoniae

Kivimäe, Juta, 1952-

2003-01-01

Tartu Ülikooli maali õppetooli üliõpilaste näitus "Tartu kevad" Kastellaanimaja galeriis. Osalevad Kadri Ilves, Piret Mikkelsen, Anna Kainulainen, Anna Mägi, Jaan-Jürgen Klaus, Merike Orav, Irina Krivonogova, Angela Orro, Peeter Krosmann, Kärt Putk, Kadi Kängsepp, Jane Remm, Liina Laaser, Ode Taul, Sami Kalevi Makkonen, Maive Õunapuu

EGFR related mutational status and association to clinical outcome of third-line cetuximab-irinotecan in metastatic colorectal cancer

Directory of Open Access Journals (Sweden)

Frifeldt Sanne K

2011-03-01

Full Text Available Abstract Background As supplement to KRAS mutational analysis, BRAF and PIK3CA mutations as well as expression of PTEN may account for additional non-responders to anti-EGFR-MoAbs treatment. The aim of the present study was to investigate the utility as biomarkers of these mutations in a uniform cohort of patients with metastatic colorectal cancer treated with third-line cetuximab/irinotecan. Methods One-hundred-and-seven patients were prospectively included in the study. Mutational analyses of KRAS, BRAF and PIK3CA were performed on DNA from confirmed malignant tissue using commercially available kits. Loss of PTEN and EGFR was assessed by immunohistochemistry. Results DNA was available in 94 patients. The frequency of KRAS, BRAF and PIK3CA mutations were 44%, 3% and 14%, respectively. All were non-responders. EGF receptor status by IHC and loss of PTEN failed to show any clinical importance. KRAS and BRAF were mutually exclusive. Supplementing KRAS analysis with BRAF and PIK3CA indentified additional 11% of non-responders. Patient with any mutation had a high risk of early progression, whereas triple-negative status implied a response rate (RR of 41% (p Conclusion Triple-negative status implied a clear benefit from treatment, and we suggest that patient selection for third-line combination therapy with cetuximab/irinotecan could be based on triple mutational testing.

First Person Past: American Autobiographies, Volume 2

DEFF Research Database (Denmark)

American literature, biography, Tunis Campbell, Black Elk, Andrew Carnegie, Booker T. Washington, Mary Antin, Mary Jones, Frederic Howe, Anna Howard Shaw, Woody Guthrie, Monica Sone, Anne Moody, Ron Kovic......American literature, biography, Tunis Campbell, Black Elk, Andrew Carnegie, Booker T. Washington, Mary Antin, Mary Jones, Frederic Howe, Anna Howard Shaw, Woody Guthrie, Monica Sone, Anne Moody, Ron Kovic...

Haṭhapradīpikā

DEFF Research Database (Denmark)

Olesen, Bjarne Wernicke; Einarsen, Silje Lyngar; , .

), prāṇāyāma (åndedrætsteknikker), mudrā (yogiske teknikker) og samādhi (meditative indsigter). Dertil er HYP et encyklopædisk værk (formodentligt sammensat af mere end 20 forskellige yogaskrifter) fra haṭhayogaens klassisk-formative fase, hvorfor værket tillige udgør en forståelsesnøgle til yoga, tantra og...

Bringing Climate Into the Classroom: Inside a Teaching Retreat Around Naomi Klein’s This Changes Everything

Directory of Open Access Journals (Sweden)

Bill Bigelow

2015-06-01

Full Text Available Jill Howdyshell lives and teaches 5th grade in Togiak, a small Yu’pik fishing village in southwestern Alaska. In Togiak, harvesting berries is a practice that goes back countless generations. The berries are the key ingredient in akutaq, called eskimo ice cream. In her classes, Howdyshell’s students write identity poems with lines proclaiming “I am from akutaq,” and describing cherished excursions with parents and grandparents. In 2014, residents discovered that there would be no berries that year: the tundra had not frozen for a sufficient length of time for the berries to regenerate. With a dramatic rise in temperatures, Yu’pik people can no longer rely on digging deep into the permafrost to store food in makeshift freezers. And most distressing: as a result of rising seas, during the next few years, Yu’pik people will be forced to relocate large parts of their community.

The Prognostic Influence of BRAF Mutation and other Molecular, Clinical and Laboratory Parameters in Stage IV Colorectal Cancer.

Science.gov (United States)

Karadima, Maria L; Saetta, Angelica A; Chatziandreou, Ilenia; Lazaris, Andreas C; Patsouris, Efstratios; Tsavaris, Nikolaos

2016-10-01

Our aim was to evaluate the predictive and prognostic influence of BRAF mutation and other molecular, clinical and laboratory parameters in stage IV colorectal cancer (CRC). 60 patients were included in this retrospective analysis, and 17 variables were examined for their relation with treatment response and survival. KRAS mutation was identified in 40.3 % of cases, BRAF and PIK3CA in 8.8 % and 10.5 % respectively. 29.8 % of patients responded to treatment. Median survival time was 14.3 months. Weight loss, fever, abdominal metastases, blood transfusion, hypoalbuminaimia, BRAF and PIK3CA mutations, CRP and DNA Index were associated with survival. In multivariate analysis, male patients had 3.8 times higher probability of response, increased DNA Index was inversely correlated with response and one unit raise of DNA Index augmented 6 times the probability of death. Our findings potentiate the prognostic role of BRAF, PIK3CA mutations and ploidy in advanced CRC.

Microscopic qualitative evaluation of fixation time and decalcification media in rat maxillary periodontium Avaliação microscópica qualitativa do tempo de fixação e dos meios de descalcificação do periodonto de ratos

Directory of Open Access Journals (Sweden)

Marilene Issa Fernandes

2007-06-01

Full Text Available The rat model is widely used in periodontal research and the quality of histological sections is essential. The purpose of this study was to evaluate the histological characteristics of periodontal tissues in Wistar rat maxillae, with different times of fixation and decalcified by nitric acid or formic acid (Anna Morse Solution. Fifteen rats were used. Fixation was performed for 24, 48 and 72 hours. The maxillae were hemi-sectioned and each part was decalcified either in nitric acid for 7 days or in Anna Morse solution for 35 days. Two trained and blinded examiners performed the evaluation. Fourty eight hours of fixation and decalcification with Anna Morse solution showed more clear characteristics of the epithelium-connective tissue interface and of the periodontal structures. Mean measurements between the cementum-enamel junction and the bone crest varied in the different experimental times from 176.5 (± 60.45 to 210.94 (± 39.33 pixels on the buccal aspect, and from 199.69 (± 38.33 to 298.55 (± 70.81 pixels on the palatal aspect, with no statistically significant differences (ANOVA, p > 0.05. In the same fixation period, decalcification with nitric acid or Anna Morse solution did not display any statistically significant differences. It may be concluded that for a qualitative histological analysis, fixation should preferably be for 48 hours and the demineralization should be made by Anna Morse solution. For a histomorphometric analysis, the decalcification solution does not interfere in the results.O modelo rato é extensamente usado na pesquisa periodontal, e a qualidade dos cortes histológicos é essencial. A proposta deste estudo foi avaliar as características histológicas dos tecidos periodontais nas maxilas de ratos Wistar, após diferentes períodos de fixação e descalcificação pelo ácido nítrico ou pelo ácido fórmico (Solução de Anna Morse. Quinze ratos foram usados. A fixação foi realizada nos períodos de 24, 48 e

Milano 2006 / Anna Roomet

Index Scriptorium Estoniae

Roomet, Anna

2006-01-01

Sisekujunduse- ja mööblimessist I Saloni, mis tähistas oma 45. juubelit uues asupaigas Massimiliano Fuksase kavandite järgi ehitatud Fiera Milano Rho Pero messiavenüül 5.-10. aprillil. 36 värv. ill

Tsvetotshnaja skazka / Anna Litvinjuk

Index Scriptorium Estoniae

Litvinjuk, Anna

2003-01-01

Tatjana Tridvornova organiseeritud lilleballist Tallinnas. Algas lillekleitide defileega Saku Suurhallis ja jätkus lillekleitide konkursiga klubis Opium. Žürii koosseis. Osalejad Eestist, Lätist ja Soomest. Võitja on läti florist Druvis Ciritis lillekleidiga "Puudutus"

Vsepobezhdajushtshaja strast / Anna Litvinjuk

Index Scriptorium Estoniae

Litvinjuk, Anna

2003-01-01

Professionaalsete lilleseadjate võistlusest "Lillekleit 2003" Tallinnas klubis Opium. Võitis läti lilleseadja Druvis Ciritise lillekleit "Puudutus", II koha sai Irmen Laving ja III koha Heiki Põder. Rikkalikult illustreeritud

Sportivnaja gratsija / Anna Litvinjuk

Index Scriptorium Estoniae

Litvinjuk, Anna

2006-01-01

Tallinna klubis Arctic Sport demonstreeritud firma Adidas uutest sügis-talviste spordirõivaste kollektsioonidest Adilibria ja Fuse naistele. Adilibria kollektsiooni loomisel kasutati moekunstnik Stella McCartney ideesid

Posvjashtshenije muzam / Anna Litvinjuk

Index Scriptorium Estoniae

Litvinjuk, Anna

2003-01-01

Tallinna Vene Draamateatri galeriis avatakse maalinäitus "Pühendus teatrile". Kunstnikud A. Strahhov, S. Semerikov, S. ja V. Inkatovid, E. Sterpu, V. Voitsehhovitsh ja S. Minin oma teatrikogemustest ja töödest näitusel

Rabotorgovlja protsvetajet / Anna Litvinjuk

Index Scriptorium Estoniae

Litvinjuk, Anna

2004-01-01

India päritolu ameeriklanna Rania Hong, kes ise sattus lapsepõlves illegaalse inimkaubanduse ohvriks, tegeleb alates 1999. aastast selgitustööga ja ohvrite abistamisega rahvusvahelise organisatsiooni Shared Hope International töötajana

Получая образование в Эстонии, открываем для себя мир / Рейли Аргус

Index Scriptorium Estoniae

Аргус, Рейли, 1967-

2011-01-01

Tallinna Ülikoolis õpetatavast bakalaureusetaseme erialast eesti keel võõrkeelena ja eesti kultuur. Magistritasemel saab õppida eesti keele kui võõrkeele õpetajaks. Selle eriala Ida-Virumaalt pärit vilistlased ja üliõpilased Anna Šiškova, Maaja Orlova, Deniss Jegorov, Anna Pirk, Jekaterina Ozernova ja Anastassia Šmõreitšik selgitavad eriala valimise, õppimise, Tallinnas kohanemise ja enda edasise elu kohta.

Meie enda kodune kõrgharidus ja järjest avaram maailm / Reili Argus

Index Scriptorium Estoniae

Argus, Reili, 1967-

2011-01-01

Tallinna Ülikoolis õpetatavast bakalaureusetaseme erialast eesti keel võõrkeelena ja eesti kultuur. Magistritasemel saab õppida eesti keele kui võõrkeele õpetajaks. Selle eriala Ida-Virumaalt pärit vilistlased ja üliõpilased Anna Šiškova, Maaja Orlova, Deniss Jegorov, Anna Pirk, Jekaterina Ozernova ja Anastassia Šmõreitšik selgitavad eriala valimise, õppimise, Tallinnas kohanemise ja enda edasise elu kohta

Russian Weaponization of Information and Influence in the Baltic States

Science.gov (United States)

2016-12-11

24 Anna Bulakh et al., “Russian Soft Power and Non-Military Influence: The View from Estonia,” in Tools of...Bulakh, Anna , Julian Typay, Karel Kaas, Emmet Tuohy, Kristiina Visnapuu, and Juhan Kivirahk. “Russian Soft Power and Non-Military Influence: The View...Command and General Staff College in partial fulfillment of the requirements for the degree MASTER OF MILITARY ART AND SCIENCE Strategic Studies

Multifunctional Materials and Structures Gordon Research Conference

Science.gov (United States)

2016-03-08

Technology and Design, Singapore) 7:30 pm - 7:35 pm Introduction by Discussion Leader 7:35 pm - 8:10 pm Anna Balazs (University of Pittsburgh, USA...Athanasopoulos, N University of Patras Poster Presenter Registered Balazs, Anna C University of Pittsburgh Speaker Registered Barth, Friedrich G...Ozden O Texas A&M University Attendee Registered Olson , Jeff Lockheed Martin Space Systems Company Poster Presenter Registered Peijs, Ton Queen

2016 Multifunctional Materials and Structures: Science of Autonomic, Adaptive and Self-Sustaining Systems GRC

Science.gov (United States)

2016-02-23

Design, Singapore) 7:30 pm - 7:35 pm Introduction by Discussion Leader 7:35 pm - 8:10 pm Anna Balazs (University of Pittsburgh, USA) "Designing...N University of Patras Poster Presenter Registered Balazs, Anna C University of Pittsburgh Speaker Registered Barth, Friedrich G. University of...Texas A&M University Attendee Registered Olson , Jeff Lockheed Martin Space Systems Company Poster Presenter Registered Peijs, Ton Queen Mary

Evaluation of Proctophyllodes huitzilopochtlii on feathers from Anna’s (Calypte anna) and Black-chinned (Archilochus alexandri) Hummingbirds: Prevalence assessment and imaging analysis using light and tabletop scanning electron microscopy

Science.gov (United States)

Yamasaki, Youki K.; Graves, Emily E.; Kysar, Patricia E.; Straub, Mary H.

2018-01-01

Proctophyllodes huitzilopochtlii Atyeo & Braasch 1966 (Acariformes: Astigmata: Proctophyllodidae), a feather mite, was found on feathers collected from five hummingbird species in California. This mite has not been previously documented on feathers from Anna’s (Calypte anna [Lesson 1829]) or Black-chinned (Archilochus alexandri [Bourcier & Mulsant 1846]) Hummingbirds. A total of 753 hummingbirds were evaluated for the presence of mites by species (Allen’s n = 112; Anna’s n = 500; Black-chinned n = 122; Rufous n = 18; Calliope n = 1), sex (males n = 421; females n = 329; 3 unidentified), and age (juvenile n = 199; after-hatch-year n = 549; 5 unidentified). Of these 753 hummingbirds evaluated, mites were present on the rectrices of 40.9% of the birds. Significantly more Anna’s Hummingbirds were positive for rectricial mites (59.2%) compared with 8.2% of Black-chinned, 0.9% of Allen’s, 5.6% of Rufous Hummingbirds, and 0% for Calliope (p-value hummingbird species, male hummingbirds (44.9%) had a higher prevalence of rectricial mites compared to female hummingbirds (36.2%; p-value = 0.004), while juvenile hummingbirds (46.2%) had a non-significantly higher prevalence compared to after-hatch-year hummingbirds (39.0%; p-value = 0.089). On average, the percentage of the long axis of the rachis occupied by mites for the outer rectrices (R4 and R5) was 19%, compared to 11% for inner rectrices (R1 and R2), a significant difference (p-value = hummingbird–feather mite relationship is not well understood, but the specialized TSEM technique may be especially useful in examining natural positioning and developmental aspects of the mites since it allows in situ feather examination of live mites. PMID:29444089

World Foundation for Renal Care: helping acute and chronic renal failure patients and their families worldwide: an interview with Geraldine Biddle.

Science.gov (United States)

Biddle, G

2000-12-01

In this interview, Geraldine Biddle, president and co-founder of the World Foundation for Renal Care (WFRC), describes the organization's beginnings and the progress it has made toward its mission and vision. Ms. Biddle also details the historic involvement of ANNA informing WFRC and participating in its activities. Founded in 1997, the WFRC has its world headquarters in London and currently has three ANNA past presidents on its Board of Directors.

Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

Science.gov (United States)

Camps, Montserrat; Rückle, Thomas; Ji, Hong; Ardissone, Vittoria; Rintelen, Felix; Shaw, Jeffrey; Ferrandi, Chiara; Chabert, Christian; Gillieron, Corine; Françon, Bernard; Martin, Thierry; Gretener, Denise; Perrin, Dominique; Leroy, Didier; Vitte, Pierre-Alain; Hirsch, Emilio; Wymann, Matthias P; Cirillo, Rocco; Schwarz, Matthias K; Rommel, Christian

2005-09-01

Phosphoinositide 3-kinases (PI3K) have long been considered promising drug targets for the treatment of inflammatory and autoimmune disorders as well as cancer and cardiovascular diseases. But the lack of specificity, isoform selectivity and poor biopharmaceutical profile of PI3K inhibitors have so far hampered rigorous disease-relevant target validation. Here we describe the identification and development of specific, selective and orally active small-molecule inhibitors of PI3Kgamma (encoded by Pik3cg). We show that Pik3cg(-/-) mice are largely protected in mouse models of rheumatoid arthritis; this protection correlates with defective neutrophil migration, further validating PI3Kgamma as a therapeutic target. We also describe that oral treatment with a PI3Kgamma inhibitor suppresses the progression of joint inflammation and damage in two distinct mouse models of rheumatoid arthritis, reproducing the protective effects shown by Pik3cg(-/-) mice. Our results identify selective PI3Kgamma inhibitors as potential therapeutic molecules for the treatment of chronic inflammatory disorders such as rheumatoid arthritis.

NRC Information Notice No. 93-22: Tripping of Klockner-Moeller molded-case circuit breakers due to support lever failure

International Nuclear Information System (INIS)

Grimes, B.K.

1993-01-01

On July 1, 1992, Virginia Electric and Power Company (VEPCO), licensee for North Anna Power Station (North Anna), Units 1 and 2, reported to the NRC that over a three-month period in 1992, three K-M model NZM6-63, 480-Vac MCCBs had tripped without appreciable load or fault condition or other electrical or mechanical transient. The three failed MCCBs were located in the cable vault and tunnel area of North Anna-2 and supplied power to motor operated valves in the charging and safety injection systems. The switch handles were found in the trip-free position and the breakers could not be relatched and reclosed. Examination of the internals of one of the three failed breakers revealed that its support lever (also described by VEPCO as a ''spring arm''), located in the rear compartment of the case, had fractured. This caused the breaker to trip and to become incapable of being reclosed. The NRC has determined that the support levers only in K-M model NZM6, NZM6b, and NZMH6 MCCBs, rated for 100 amperes and below and manufactured from 1972 on, have been made of the same type of plastic used in the support levers of the MCCBs that failed at North Anna-2

Diversity along a speciation continuum : ecology and morphology of northern European whitefish (Coregonus lavaretus)

OpenAIRE

Siwertsson, Anna

2012-01-01

Papers 1 and 4 of this thesis are not available in Munin: 1. Anna Siwertsson, Rune Knudsen and Per-Arne Amundsen: 'Temporal stability in gill raker numbers of subarctic European whitefish populations', Advances in Limnology (2012), vol. 63:229-240. Available at http://www.schweizerbart.de/papers/adv_limnology/detail/63/77932/Temporal_stability_ingill_raker_numbers_of_subarct 4. Anna Siwertsson, Rune Knudsen, Colin Adams and Per-Arne Amundsen: 'Replicated morphological divergence supports inci...

Double loading and unloading plant for EHB containers

Energy Technology Data Exchange (ETDEWEB)

Arntz, H.; Kalle, N.; Miebach, K.

1986-04-01

An integrated haulage system was installed for the shafts of the 'Eschweiler Bergwerksverein', Emil Mayrisch colliery and Anna colliery for the purpose of cost reduction. Transport problems resulting from different floor levels and track gauges were solved by means of a double loading and unloading plant for EHB containers at the 860 m level of Anna mine. The mode of operation, the hydraulic system, and the control system of the loading and unloading plant are described.

Targeted capture massively parallel sequencing analysis of LCIS and invasive lobular cancer: Repertoire of somatic genetic alterations and clonal relationships.

Science.gov (United States)

Sakr, Rita A; Schizas, Michail; Carniello, Jose V Scarpa; Ng, Charlotte K Y; Piscuoglio, Salvatore; Giri, Dilip; Andrade, Victor P; De Brot, Marina; Lim, Raymond S; Towers, Russell; Weigelt, Britta; Reis-Filho, Jorge S; King, Tari A

2016-02-01

Lobular carcinoma in situ (LCIS) has been proposed as a non-obligate precursor of invasive lobular carcinoma (ILC). Here we sought to define the repertoire of somatic genetic alterations in pure LCIS and in synchronous LCIS and ILC using targeted massively parallel sequencing. DNA samples extracted from microdissected LCIS, ILC and matched normal breast tissue or peripheral blood from 30 patients were subjected to massively parallel sequencing targeting all exons of 273 genes, including the genes most frequently mutated in breast cancer and DNA repair-related genes. Single nucleotide variants and insertions and deletions were identified using state-of-the-art bioinformatics approaches. The constellation of somatic mutations found in LCIS (n = 34) and ILC (n = 21) were similar, with the most frequently mutated genes being CDH1 (56% and 66%, respectively), PIK3CA (41% and 52%, respectively) and CBFB (12% and 19%, respectively). Among 19 LCIS and ILC synchronous pairs, 14 (74%) had at least one identical mutation in common, including identical PIK3CA and CDH1 mutations. Paired analysis of independent foci of LCIS from 3 breasts revealed at least one common mutation in each of the 3 pairs (CDH1, PIK3CA, CBFB and PKHD1L1). LCIS and ILC have a similar repertoire of somatic mutations, with PIK3CA and CDH1 being the most frequently mutated genes. The presence of identical mutations between LCIS-LCIS and LCIS-ILC pairs demonstrates that LCIS is a clonal neoplastic lesion, and provides additional evidence that at least some LCIS are non-obligate precursors of ILC. Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Molecular Subgroup Analysis of Clinical Outcomes in a Phase 3 Study of Gemcitabine and Oxaliplatin with or without Erlotinib in Advanced Biliary Tract Cancer

Directory of Open Access Journals (Sweden)

Seung Tae Kim

2015-02-01

Full Text Available BACKGROUND: We previously reported that the addition of erlotinib to gemcitabine and oxaliplatin (GEMOX resulted in greater antitumor activity and might be a treatment option for patients with biliary tract cancers (BTCs. Molecular subgroup analysis of treatment outcomes in patients who had specimens available for analysis was undertaken. METHODS: Epidermal growth factor receptor (EGFR, KRAS, and PIK3CA mutations were evaluated using peptide nucleic acid–locked nucleic acid polymerase chain reaction clamp reactions. Survival and response rates (RRs were analyzed according to the mutational status. Sixty-four patients (48.1% were available for mutational analysis in the chemotherapy alone group and 61 (45.1% in the chemotherapy plus erlotinib group. RESULTS: 1.6% (2/116 harbored an EGFR mutation (2 patients; exon 20, 9.6% (12/121 harbored a KRAS mutation (12 patients; exon 2, and 9.6% (12/118 harbored a PIK3CA mutation (10 patients, exon 9 and 2 patients, exon 20. The addition of erlotinib to GEMOX in patients with KRAS wild-type disease (n = 109 resulted in significant improvements in overall response compared with GEMOX alone (30.2% vs 12.5%, P = .024. In 95 patients with both wild-type KRAS and PIK3CA, there was evidence of a benefit associated with the addition of erlotinib to GEMOX with respect to RR as compared with GEMOX alone (P = .04. CONCLUSION: This study demonstrates that KRAS mutational status might be considered a predictive biomarker for the response to erlotinib in BTCs. Additionally, the mutation status of PIK3CA may be a determinant for adding erlotinib to chemotherapy in KRAS wild-type BTCs.

Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex.

Directory of Open Access Journals (Sweden)

Stanley I Rapoport

Full Text Available Phosphoinositides, lipid-signaling molecules, participate in diverse brain processes within a wide metabolic cascade.Gene transcriptional networks coordinately regulate the phosphoinositide cascade during human brain Development and Aging.We used the public BrainCloud database for human dorsolateral prefrontal cortex to examine age-related expression levels of 49 phosphoinositide metabolic genes during Development (0 to 20+ years and Aging (21+ years.We identified three groups of partially overlapping genes in each of the two intervals, with similar intergroup correlations despite marked phenotypic differences between Aging and Development. In each interval, ITPKB, PLCD1, PIK3R3, ISYNA1, IMPA2, INPPL1, PI4KB, and AKT1 are in Group 1, PIK3CB, PTEN, PIK3CA, and IMPA1 in Group 2, and SACM1L, PI3KR4, INPP5A, SYNJ1, and PLCB1 in Group 3. Ten of the genes change expression nonlinearly during Development, suggesting involvement in rapidly changing neuronal, glial and myelination events. Correlated transcription for some gene pairs likely is facilitated by colocalization on the same chromosome band.Stable coordinated gene transcriptional networks regulate brain phosphoinositide metabolic pathways during human Development and Aging.

Structure, design and statistical programme library of the meteorological database of Potsdam-Institut fuer Klimaforschung; Struktur, Aufbau und statistische Programmbibliothek der meteorologischen Datenbank am Potsdam-Institut fuer Klimaforschung

Energy Technology Data Exchange (ETDEWEB)

Oesterle, H.; Glauer, J. [Potsdam-Institut fuer Klimafolgenforschung (PIK), Potsdam (Germany); Denhard, M. [Frankfurt Univ. (Germany). Inst. fuer Meteorologie und Geophysik

1999-01-01

The relational database management system (ORACLE) using different client interfaces (browser, SQL, precompiler) is the most important basis for data organization and storage. The creation of a data bank system at PIK includes: Acquisition of meteorological data series for the projects executed at PIK; development of a database structure on the basis of daily values; control, analysis and classification of data into given storage formats; development and application of statistical software. There are currently 20 different types of data sets with daily, monthly and annual data which are functionally interconnected and updated. All data sets are continuously updated. (orig.) [Deutsch] Wesentliche Grundlage der Datenorganisation und -speicherung bildet das relationale Datenbanksystem ORACLE mit den dazugehoerigen Werkzeugen (Browser, SQL- und Precompiler). Die Entwicklung des Datenbanksystems am PIK umfasst folgende Etappen: - Erwerb von meteorologischen Datensaetzen fuer die am Institut laufenden Forschungsvorhaben; - Entwicklung einer Speicherstruktur auf der Basis von Tageswerten; - Kontrolle, Analyse und Einordnung der Daten in die vorgegebenen Speicherformate; - Entwicklung der zur Datennutzung notwendigen statistischen Programmbibliothek. Zur Zeit gibt es 20 verschiedene Typen von Datensaetzen. Sie enthalten taegliche, monatliche und jaehrliche Daten und sind funktional miteinander verbunden. Alle Datensaetze werden kontinuierlich erweitert. (orig.)

Feminist film studies ４０ years after ‘Visual Pleasure and Narrative Cinema’, a triologue

OpenAIRE

Laura Mulvey; Anna Backman Rogers; Annie van den Oever

2015-01-01

Forty years after the publication of her seminal essay ‘Visual Pleasure and Narrative Cinema’ in Screen, Laura Mulvey, together with Anna Backman Rogers, has edited Feminisms: Diversity, Difference, and Multiplicity in Contemporary Film Cultures, which is the latest instalment of The Key Debates series. NECSUS invited Laura Mulvey and Anna Backman Rogers to join Annie van den Oever, editor of NECSUS and series editor of The Key Debates, in a ‘triologue’, which in part reflects and re-empha...

Anbar Awake: What Now?

Science.gov (United States)

2009-04-01

enough local support in the area to prevent the AM from taking root.64 The rapid expansion of the AM was both stunning and game -changing. By...in between. 40 Oppel, “Iraq Takes Aim.” 41 Wong, al-Ansary, and Cooper, and Anna Badkhen, “We Were basically Hiring Terrorists,” Salon , August 29...www.worldthreats.com/?p=533 (accessed January 20, 2008). Badkhen, Anna. “We Were Basically Hiring Terrorists.” Salon , August 29, 2008. http://www.salon.com/news

The Women’s Army Corps: 1945-1978

Science.gov (United States)

1990-01-01

their new neighbors by proclaiming 21 July as "WAC Day." The main streets of the city (popu- lation 26,000) were draped with bunting and welcome...counseling the women and managing activities in the building. A WAC first sergeant, Anna M. Armour , assisted her in her command duties-administration...Utilization of women. Armor, 385 women’s command authority. See Corn- Armour , 1st Sgt. Anna M., 201 mand authority. Army, act’g ass’t secretary of for manpow

Stimulation of ICT/domotics in houses. The organization of 2 workshops. Final report; De bevordering van ICT/domotica in woningen. De organisatie van 2 workshops. Eindrapport

Energy Technology Data Exchange (ETDEWEB)

Romer, J.C. [ECN Duurzame Energie in de Gebouwde Omgeving DEGO, Petten (Netherlands)

2003-07-01

The title project concerns the organization of two workshops on two concrete projects: (1) a building project for 43 dwellings for elderly people in Anna Paulowna, Netherlands, and (2) the building of a home for the elderly people (called Parkzicht) in Hippolytushoef, Netherlands. Preparatory activities for and the organization of the two workshops are described. The first workshop was held October 4th, 2002. The second workshop was planned for December 13th, 2002, but was cancelled. [Dutch] Een overzicht wordt gegeven van de activiteiten die hebben plaatsgevonden rond 2 concreet te realiseren projecten in Noord-Holland. De activiteiten bestaan uit de voorbereidende activiteiten en de organisatie van twee workshops. Een van de projecten betreft de bouw van 43 woningen voor senioren in Anna Paulowna en het andere project betreft de bouw van het verzorgingstehuis Parkzicht in Hippolytushoef. De 'Anna Paulowna' workshop werd 4 oktober 2002 gehouden. De Hippolytushoef workshop was gepland op 13 december 2002 maar is niet doorgegaan.

Corrigendum: Request that it is necessary to correct affiliations of the authors of the paper: Numerical model and experimental validation of the heat transfer in air cooled solar photovoltaic panel, https://doi.org/10.2298/TSCI16S4071R

Directory of Open Access Journals (Sweden)

Editorial

2017-01-01

Full Text Available Senthil Kumar RANGANATHANa*, Natarajan ELUMALAIb, and Puja Priyadharshini NATARAJANc aDepartment of Mechanical Engineering, Institute for Energy Studies, Anna University, Chennai, India bDepartment of Mechanical Engineering, KCG College of Technology, Chennai, India has to be written as: Senthil Kumar RANGANATHANa*, Natarajan ELUMALAIa, and Puja Priyadharshini NATARAJANb aDepartment of Mechanical Engineering, Institute for Energy Studies, Anna University, Chennai, India bDepartment of Mechanical Engineering, KCG College of Technology, Chennai, India Link to the corrected article 10.2298/TSCI16S4071R

Dostojevski bez nakipi / Anna Moleva

Index Scriptorium Estoniae

Moleva, Anna

2002-01-01

Fjodor Dostojevski romaani "Idioot" järgi filmitud 10-osalise samanimelise Venemaa draamaseriaali valmimisest : režissöör Vladimir Bortko. Oma arvamust avaldavad produtsent Valeri Todorovski, näitlejad Oleg Basilashvili, Vladimir Mashkov, Jevgeni Mironov, Andrei Smirnov, Mihhail Bojarski, Maria Kisseljova, Sasha Lazarev

An appreciation of Anna Mani

Indian Academy of Sciences (India)

Lawrence

time she was twelve, all the books in English. On her eighth birthday she ... insisted that lack of a Ph.D. degree made little difference in her life. She left for ... tailed knowledge of solar fluxes and wind patterns in different re- gions of India, and it ...

Zhertvõ "Strastei" / Anna Fedina

Index Scriptorium Estoniae

Fedina, Anna

2004-01-01

Mel Gibsoni mängufilmi "Kristuse kannatused" ("The Passion of Christ") seanssidel on saanud infarkti juba kaks vaatajat ning mõrva üles tunnistanud üks kurjategija. Kiirabi oli valves ka Iirimaa esilinastuse ajal. Südame atakke on juhtunud ka Lars von Trieri filmide näitamise ajal

Peizazh v oprave / Anna Litvinjuk

Index Scriptorium Estoniae

Litvinjuk, Anna

2004-01-01

Vene Draamateatri galerii avas teatri remondi tõttu hooaja juveelikeskuses Bindes Tartu mnt. 10. Maalinäitusel "Peizazh" osaleb 15 eesti kunstnikku. Nendest on mainitud V. Laur, V. Inkatov, S. Semerikov, A. Strahhov, E. Zentshik ja M. Leis. Avamisel näitas moekunstnik D. Denissova oma uut suvekollektsiooni

SÄSI konkurss / Anna Roomet

Index Scriptorium Estoniae

Roomet, Anna

2006-01-01

Konkursist, auhinnatseremooniast ja ekspositsioonist Arhitektuuri- ja Disainigaleriis, žürii koosseis. Intervjuu eesti parima noore disaineri preemia SÄSI pälvinud Pavel Sidorenko ning väikese SÄSI saanud Björn Koobi, Ülle Jehe ja Igor Volkoviga

Muzei rabotajet otlitshno! / Anna Mets

Index Scriptorium Estoniae

Mets, Anna

2006-01-01

Peterburi Vene Muuseumi Kohtla-Järve virtuaalse filiaali "Vene muuseum : Virtuaalne filiaal" tööst rääkis oma ettekandes rahvusvahelisel muuseumide ümarlaual Peterburis filiaali juhataja Nadezhda Arikainen

Karikatura i meditatsija / Anna Litvinjuk

Index Scriptorium Estoniae

Litvinjuk, Anna

2003-01-01

Aserbaidžaani kunstniku Rashid Sherifi tööde näitus Tallinnas Kodulinna Majas. Enne seda eksponeeriti Sherifi töid Ugala teatris, kus ta oli näidendi "Dekameron" külaliskunstnikuks. Kunstnik oma töödest

Zdorovje - nash ressurss / Anna Litvinjuk

Index Scriptorium Estoniae

Litvinjuk, Anna

2005-01-01

Ülemaailmse Tervishoiuorganisatsiooni (WHO) andmetel on keskmine eluiga Eestis tunduvalt lühem kui teistes EL-i riikides. Samuti on Eesti elanike tervis võrreldes teiste EL-i riikide elanike tervisega tunduvalt halvem. WHO toetusel toimunud tervisefoorumist Eestis. Diagramm

Podcast - Interview with Anna Sfard

DEFF Research Database (Denmark)

2006-01-01

During the 14th - 17th of November PhD Students and researchers from e-learning lab attended a PhD course called "Perspectives on Identity in Learning and Education Research". This course was co-organised by three local doctoral schools; The International Doctoral school of Technology and Science...

δ-Tocopherol inhibits receptor tyrosine kinase-induced AKT activation in prostate cancer cells.

Science.gov (United States)

Wang, Hong; Hong, Jungil; Yang, Chung S

2016-11-01

The cancer preventive activity of vitamin E is suggested by epidemiological studies and supported by animal studies with vitamin E forms, γ-tocopherol and δ-tocopherol (δ-T). Several recent large-scale cancer prevention trials with high dose of α-tocopherol, however, yielded disappointing results. Whether vitamin E prevents or promotes cancer is a serious concern. A better understanding of the molecular mechanisms of action of the different forms of tocopherols would enhance our understanding of this topic. In this study, we demonstrated that δ-T was the most effective tocopherol form in inhibiting prostate cancer cell growth, by inducing cell cycle arrest and apoptosis. By profiling the effects of δ-T on the cell signaling using the phospho-kinase array, we found that the most inhibited target was the phosphorylation of AKT on T308. Further study on the activation of AKT by EGFR and IGFR revealed that δ-T attenuated the EGF/IGF-induced activation of AKT (via the phosphorylation of AKT on T308 induced by the activation of PIK3). Expression of dominant active PIK3 and AKT in prostate cancer cell line DU145 in which PIK3, AKT, and PTEN are wild type caused the cells to be reflectory to the inhibition of δ-T, supporting that δ-T inhibits the PIK3-mediated activation of AKT. Our data also suggest that δ-T interferes with the EGF-induced EGFR internalization, which leads to the inhibition of the receptor tyrosine kinase-dependent activation of AKT. In summary, our results revealed a novel mechanism of δ-T in inhibiting prostate cancer cell growth, supporting the cancer preventive activity δ-T. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

Revealing the Effects of the Herbal Pair of Euphorbia kansui and Glycyrrhiza on Hepatocellular Carcinoma Ascites with Integrating Network Target Analysis and Experimental Validation.

Science.gov (United States)

Zhang, Yanqiong; Lin, Ya; Zhao, Haiyu; Guo, Qiuyan; Yan, Chen; Lin, Na

2016-01-01

Although the herbal pair of Euphorbia kansui (GS) and Glycyrrhiza (GC) is one of the so-called "eighteen antagonistic medicaments" in Chinese medicinal literature, it is prescribed in a classic Traditional Chinese Medicine (TCM) formula Gansui-Banxia-Tang for cancerous ascites, suggesting that GS and GC may exhibit synergistic or antagonistic effects in different combination designs. Here, we modeled the effects of GS/GC combination with a target interaction network and clarified the associations between the network topologies involving the drug targets and the drug combination effects. Moreover, the "edge-betweenness" values, which is defined as the frequency with which edges are placed on the shortest paths between all pairs of modules in network, were calculated, and the ADRB1-PIK3CG interaction exhibited the greatest edge-betweenness value, suggesting its crucial role in connecting the other edges in the network. Because ADRB1 and PIK3CG were putative targets of GS and GC, respectively, and both had functional interactions with AVPR2 approved as known therapeutic target for ascites, we proposed that the ADRB1-PIK3CG-AVPR2 signal axis might be involved in the effects of the GS-GC combination on ascites. This proposal was further experimentally validated in a H22 hepatocellular carcinoma (HCC) ascites model. Collectively, this systems-level investigation integrated drug target prediction and network analysis to reveal the combination principles of the herbal pair of GS and GC. Experimental validation in an in vivo system provided convincing evidence that different combination designs of GS and GC might result in synergistic or antagonistic effects on HCC ascites that might be partially related to their regulation of the ADRB1-PIK3CG-AVPR2 signal axis.

¿Más allá de la postmodernidad?: ‘Countdown’, Beyoncé y Keersmaeker

OpenAIRE

Sanjuán Astigarraga, José Ignacio

2017-01-01

La cantante americana Beyoncé utiliza en el videoclip de la canción Countdown elementos de dos coreografías de Anna Teresa De Keersmaeker. El presente texto intenta establecer qué elementos toma Beyoncé de las obras de Keersmaeker y cómo se relaciona esta apropiación con otras imágenes (Audrey Hepburn, Diana Ross) que también aparecen en el vídeo American singer Beyoncé used in the music video for the song Countdown elements of two choreographies by Anna Teresa De Keersmaeke...

Feminist film studies ４０ years after ‘Visual Pleasure and Narrative Cinema’, a triologue

Directory of Open Access Journals (Sweden)

Laura Mulvey

2015-04-01

Full Text Available Forty years after the publication of her seminal essay ‘Visual Pleasure and Narrative Cinema’ in Screen, Laura Mulvey, together with Anna Backman Rogers, has edited Feminisms: Diversity, Difference, and Multiplicity in Contemporary Film Cultures, which is the latest instalment of The Key Debates series. NECSUS invited Laura Mulvey and Anna Backman Rogers to join Annie van den Oever, editor of NECSUS and series editor of The Key Debates, in a ‘triologue’, which in part reflects and re-emphasises the topics publicly discussed during the Feminisms symposia.

Prognostic and predictive value of p-Akt, EGFR, and p-mTOR in early breast cancer

International Nuclear Information System (INIS)

Lazaridis, Georgios; Lambaki, Sofia; Karayannopoulou, Georgia; Eleftheraki, Anastasia G.; Papaspirou, Irene; Bobos, Mattheos; Efstratiou, Ioannis; Pentheroudakis, George; Zamboglou, Nikolaos; Fountzilas, George; Aristotle Univ. of Thessaloniki School of Medicine, Thessaloniki

2014-01-01

There are scarce data available on the prognostic/predictive value of p-Akt and p-mTOR protein expression in patients with high-risk early breast cancer. Formalin-fixed paraffin-embedded (FFPE) tumor tissue samples from 997 patients participating in two adjuvant phase III trials were assessed for EGFR, PTEN, p-Akt, p-mTOR protein expression, and PIK3CA mutational status. These markers were evaluated for associations with each other and with selected patient and tumor characteristics, immunohistochemical subtypes, disease-free survival (DFS), and overall survival (OS). p-mTOR protein expression was negatively associated with EGFR and positively associated with PTEN, with p-Akt473, and with the presence of PIK3CA mutations. EGFR expression was positively associated with p-Akt473, p-Akt308, and PIK3CA wild-type tumors. Finally, p-Akt308 was positively associated with p-Akt473 expression. In univariate analysis, EGFR (p = 0.016) and the coexpression of EGFR and p-mTOR (p = 0.015) were associated with poor OS. Among patients with p-Akt308-negative or low-expressing tumors, those treated with hormonal therapy were associated with decreased risk for both relapse and death (p = 0.013 and p [de

Role of p38 MAPK in enhanced human cancer cells killing by the combination of aspirin and ABT-737

Science.gov (United States)

Zhang, Chong; Shi, Jing; Mao, Shi-ying; Xu, Ya-si; Zhang, Dan; Feng, Lin-yi; Zhang, Bo; Yan, You-you; Wang, Si-cong; Pan, Jian-ping; Yang, You-ping; Lin, Neng-ming

2015-01-01

Regular use of aspirin after diagnosis is associated with longer survival among patients with mutated-PIK3CA colorectal cancer, but not among patients with wild-type PIK3CA cancer. In this study, we showed that clinically achievable concentrations of aspirin and ABT-737 in combination could induce a synergistic growth arrest in several human PIK3CA wild-type cancer cells. In addition, our results also demonstrated that long-term combination treatment with aspirin and ABT-737 could synergistically induce apoptosis both in A549 and H1299 cells. In the meanwhile, short-term aspirin plus ABT-737 combination treatment induced a greater autophagic response than did either drug alone and the combination-induced autophagy switched from a cytoprotective signal to a death-promoting signal. Furthermore, we showed that p38 acted as a switch between two different types of cell death (autophagy and apoptosis) induced by aspirin plus ABT-737. Moreover, the increased anti-cancer efficacy of aspirin combined with ABT-737 was further validated in a human lung cancer A549 xenograft model. We hope that this synergy may contribute to failure of aspirin cancer therapy and ultimately lead to efficacious regimens for cancer therapy. PMID:25388762

Gene Expression Correlation for Cancer Diagnosis: A Pilot Study

Directory of Open Access Journals (Sweden)

Binbing Ling

2014-01-01

Full Text Available Poor prognosis for late-stage, high-grade, and recurrent cancers has been motivating cancer researchers to search for more efficient biomarkers to identify the onset of cancer. Recent advances in constructing and dynamically analyzing biomolecular networks for different types of cancer have provided a promising novel strategy to detect tumorigenesis and metastasis. The observation of different biomolecular networks associated with normal and cancerous states led us to hypothesize that correlations for gene expressions could serve as valid indicators of early cancer development. In this pilot study, we tested our hypothesis by examining whether the mRNA expressions of three randomly selected cancer-related genes PIK3C3, PIM3, and PTEN were correlated during cancer progression and the correlation coefficients could be used for cancer diagnosis. Strong correlations (0.68≤r≤1.0 were observed between PIK3C3 and PIM3 in breast cancer, between PIK3C3 and PTEN in breast and ovary cancers, and between PIM3 and PTEN in breast, kidney, liver, and thyroid cancers during disease progression, implicating that the correlations for cancer network gene expressions could serve as a supplement to current clinical biomarkers, such as cancer antigens, for early cancer diagnosis.

First observation of $\\pi^{-}K^+$ and $\\pi^{+}K^-$ atoms, their lifetime measurement and $\\pi K$ scattering lengths evaluation

CERN Document Server

Afanasyev, Leonid

2016-01-01

The Low Energy QCD allows to calculate the ππ and π K scattering lengths with high precision. There are accurate relations between these scattering lengths and π + π − , π − K + , π + K − atoms lifetimes. The experiment on the first observation of π − K + and π + K − atoms is described. The atoms were generated in Nickel and Platinum targets hit by the PS CERN proton beam with momentum of 24 GeV/ c . Moving in the target, part of atoms break up producing characteristic π K pairs (atomic pairs) with small relative momentum Q in their c.m.s. In the experiment, we detected n A = 349 ± 62 (5.6 standard deviations) π − K + and π + K − atomic pairs. The main part of π K pairs are produced in free state. The majority of such particles are generated directly or from short-lived sources as ρ , ω and similar resonances. The electromagnetic interactions in the final state create Coulomb pairs with a known sharp dependence on Q . This effect allows to evaluate the number of these Coulomb pai...

CERN's 60th anniversary celebrations: "Cook"ed to perfection

CERN Multimedia

CERN Bulletin

2014-01-01

On 29 September, CERN celebrated its 60th anniversary with a gala celebration. Hundreds of CERN staff members and users, dignitaries from CERN Member States and representatives of international organisations filled the marquee for a ceremony featuring speeches as well as music from the EU Youth Orchestra. CERN Recruitment Unit section leader Anna Cook was called in at the last minute to host the ceremony.   Anna had just got back from a run on her day off when she got the call. On the line CERN60 project leader Sascha Schmeling, Globe manager Bernard Pellequer and video editor Jacques Fichet had a problem. French-Swiss journalist Darius Rochebin, who had been pegged to host CERN's 60th anniversary ceremony, had been forced to cancel at the last minute, just three days before the event. Would Anna host the celebration – a ceremony to be attended by hundreds and broadcast around the world for all to see? After asking whether it was a joke, she said: “OK, I&rsquo...

Biogeography and taxonomy of racket-tail hummingbirds (Aves: Trochilidae: Ocreatus): evidence for species delimitation from morphology and display behavior.

Science.gov (United States)

Schuchmann, Karl-L; Weller, André-A; Jürgens, Dietmar

2016-11-27

We analyzed geographic variation, biogeography, and intrageneric relationships of racket-tail hummingbirds Ocreatus (Aves, Trochilidae). Presently, the genus is usually considered monospecific, with O. underwoodii including eight subspecies (polystictus, discifer, underwoodii, incommodus, melanantherus, peruanus, annae, addae), although up to three species have been recognized by some authors. In order to evaluate the current taxonomy we studied geographic variation in coloration, mensural characters, and behavioral data of all Ocreatus taxa. We briefly review the taxonomic history of the genus. Applying the Biological Species Concept, species delimitation was based on a qualitative-quantitative criteria analysis including an evaluation of character states. Our results indicate that the genus should be considered a superspecies with four species, the monotypic Ocreatus addae, O. annae, and O. peruanus, and the polytypic O. underwoodii (including the subspecies underwoodii, discifer, incommodus, melanantherus, polystictus). In this taxonomic treatment, O. annae becomes an endemic species to Peru and O. addae is endemic to Bolivia. We recommend additional sampling of distributional, ethological, and molecular data for an improved resolution of the evolutionary history of Ocreatus.

Identification of Epigenetic Changes in Prostate Cancer using Induced Pluripotent Stem Cells

Science.gov (United States)

2013-04-01

NDUFA12,CYC1,DHODH,NDUFA2,COX7C Melanoma Signaling 8.10E-01 6.52E-02 PIK3C3,CDK4,MDM2 Maturity Onset Diabetes of Young ( MODY ) Signaling 7.99E-01 6.45E...ACTG1,CACNA1A Inhibition of Angiogenesis by TSP1 1.63E+00 1.03E-01 CD47,SDC1,GUCY1A3,MAPK10 Type I Diabetes Mellitus Signaling 1.61E+00 6.67E-02...Pathway 5.02E-01 5.71E-02 CCNH,POLR2K Type II Diabetes Mellitus Signaling 4.89E-01 3.11E-02 MAP3K7,PIK3C3,MAPK10,SOCS5,PRKCB Hereditary Breast Cancer

An improved $\\pi$K atom lifetime measurement

CERN Document Server

Yazkov, V

2016-01-01

This note describes details of analysis of data samples collected by DIRAC experiment on a Pt target in 2007 and Ni targets in 2008–2010 in order to estimate the lifetime of πK atoms. Experimental results consist of eight distinct data samples: both charge combinations ( π + K − and K + π − atoms) obtained in different experimental conditions corresponding to each year of data taking. Estimations of systematic errors are presented. Taking into account both statistical and systematic uncertainties, the lifetime of πK atoms is estimated by the maximum likelihood method. The above sample comprises the total statistics, available for the analysis, thus the improvement over the previous estimation [1,3] of the πK atom lifetime is achieved.

Tõendid praktikasse / Ere Uibu, Ester Öpik

Index Scriptorium Estoniae

Uibu, Ere

2016-01-01

Eesti Õdede Liidu konverentsil tunnustati meditsiiniõdesid Sirje Kõvermäge, Kadri Piiri, Evelyn Evertit, Ere Uibut, Jane Freimani, Reet Tohvret, Teija Toivarit, Jane Remmerit, Ülle Tammsaart, Lily Parmu ja Kätlin Lünekundu

High-incidence of PTEN mutations in Chinese patients with primary small cell carcinoma of the esophagus

International Nuclear Information System (INIS)

Zhang, Zhimin; Wang, Ge; Xiao, Hualiang; Xie, Fei; Zhang, Hui; Chen, Chuan; Xiao, He; Yang, Zhenzhou; Wang, Dong; Li, Zengpeng

2014-01-01

Primary small cell carcinoma of the esophagus (PSCCE) is a rare and aggressive tumor with poor prognosis. The aim of this study was to investigate the existence of EGFR, KRAS, PIK3CA and PTEN mutations in PSCCE. Clinical–pathological data and paraffin-embedded specimens were collected from 38 patients. Exons 18 to 21 of EGFR, KRAS and PIK3CA status were analyzed by real-time PCR based on ARMS and Scorpion technology in all patients, and the PTEN gene was also screened using real-time PCR and high-resolution melting curve analysis (HRMA). Only 1 (2.63%) out of 38 patients had EGFR mutations in L858R missense, and KRAS and PIK3CA were not found in the mutational spot in all patients. However, PTEN mutations presented in 14 (36.84%) out of 38 patients, including exon 5 coding for PTEN missense mutation (n =4, 10.53%), exon 6 (n =7, 18.42%), concurrent exon 5 and exon 6 (n =2, 5.26%), and exon 8 (n =1, 2.63%). Concurrent mutations of these genes were not detected in all samples. No statistically significant associations were found between the clinicopathological features and the mutation status of PTEN. The incidence of PTEN mutations in Chinese patients with PSCCE was higher than that of previous reports in other histological subtypes of esophageal cancer

Exploratory biomarker analysis for treatment response in KRAS wild type metastatic colorectal cancer patients who received cetuximab plus irinotecan

International Nuclear Information System (INIS)

Kim, Seung Tae; Ahn, Tae Jin; Lee, Eunjin; Do, In-Gu; Lee, Su Jin; Park, Se Hoon; Park, Joon Oh; Park, Young Suk; Lim, Ho Yeong; Kang, Won Ki; Kim, Suk Hyeong; Lee, Jeeyun; Kim, Hee Cheol

2015-01-01

More than half of the patients selected based on KRAS mutation status fail to respond to the treatment with cetuximab in metastatic colorectal cancer (mCRC). We designed a study to identify additional biomarkers that could act as indicators for cetuximab treatment in mCRC. We investigated 58 tumor samples from wild type KRAS CRC patients treated with cetuximab plus irinotecan (CI). We conducted the genotyping for mutations in either BRAF or PIK3CA and profiled comprehensively the expression of 522 kinase genes. BRAF mutation was detected in 5.1 % (3/58) of patients. All 50 patients showed wild type PIK3CA. Gene expression patterns that categorized patients with or without the disease control to CI were compared by supervised classification analysis. PSKH1, TLK2 and PHKG2 were overexpressed significantly in patients with the disease control to IC. The higher expression value of PSKH1 (r = 0.462, p < 0.001) and TLK2 (r = 0.361, p = 0.005) had the significant correlation to prolonged PFS. The result of this work demonstrated that expression nature of kinase genes such as PSKH1, TLK2 and PHKG2 may be informative to predict the efficacy of CI in wild type KRAS CRC. Mutations in either BRAF or PIK3CA were rare subsets in wild type KRAS CRC

Opposition to the American leadership by Brazilian nurses (1934-1938 Resistencia al liderazgo norte-americano en la formación de la enfermera brasileña (1934-1938 Resistência à liderança norte-americana na formação da enfermeira brasileira (1934-1938

Directory of Open Access Journals (Sweden)

Tânia Cristina Franco Santos

2008-02-01

Full Text Available A historical social descriptive study whose objective is to describe the circumstances where Bertha Pullen assumes as the din of Anna Nery Nursing School, to assess the strategies undertaken by Pullen to assure her position of power and prestige in the space of the school and Brazilian nursing; and to discuss about the resistance to the presence and authority of the American din, for the nurses and students, in the struggle for a national identity. Corpus analysis was made by putting photographs into context base don written documents and secondary sources. Results: The second management of Pullen was the reiteration of the American presence in the leadership of the School, despite the resistance of the nurses and students. Thus, we may assume that the second tenure of Pullen did not represent a real need that was felt by the school.Estudio histórico-social que tuvo como objetivos: describir las circunstancias en las que Bertha Pullen asume la dirección de la Escuela de Enfermería Anna Nery; analizar las estrategias emprendidas por Pullen para asegurar su posición de poder y prestigio en la escuela y en la enfermería brasileña y discutir las oposiciones frente a su presencia y autoridad como directora americana por parte de las enfermeras y alumnas en la lucha por una identidad nacional. El análisis de los documentos fue a través de la contextualización de fotografías, con base en documentos y fuentes secundarios. El estudio demostró que la segunda gestión de Bertha Pullen reiteró la presencia americana dentro del liderazgo de la Escuela de Enfermería de Anna Nery, a pesar de la resistencia de las enfermeras y alumnas. De este modo, se concluye que su segunda gestión en la Escuela de Anna Nery no representó una necesidad real o sentida por la misma escuela.Estudo histórico-social teve como objetivos: descrever as circunstâncias em que Bertha Pullen assume a direção da Escola de Enfermagem Anna Nery; analisar as estrat

78 FR 37782 - Proposed Information Collection; Comment Request; Collection of State Level Data on Nutrition...

Science.gov (United States)

2013-06-24

... Food and Nutrition Service (FNS) of the United States Department of Agriculture (USDA) would like to... assign a PIK to each person record involves matching based on name, address, sex, date of birth, and...

Energy fluxes and spectra for turbulent and laminar flows

KAUST Repository

Verma, Mahendra K.

2017-05-14

Two well-known turbulence models to describe the inertial and dissipative ranges simultaneously are by Pao~[Phys. Fluids {\\\\bf 8}, 1063 (1965)] and Pope~[{\\\\em Turbulent Flows.} Cambridge University Press, 2000]. In this paper, we compute energy spectrum $E(k)$ and energy flux $\\\\Pi(k)$ using spectral simulations on grids up to $4096^3$, and show consistency between the numerical results and predictions by the aforementioned models. We also construct a model for laminar flows that predicts $E(k)$ and $\\\\Pi(k)$ to be of the form $\\\\exp(-k)$, and verify the model predictions using numerical simulations. The shell-to-shell energy transfers for the turbulent flows are {\\\\em forward and local} for both inertial and dissipative range, but those for the laminar flows are {\\\\em forward and nonlocal}.

"Kohtume Eestis!" algtaseme keelefunktsioonidest lähtudes / Elle Sõrmus

Index Scriptorium Estoniae

Sõrmus, Elle

2002-01-01

Rets. rmt.: Sander, Klarika. Kohtume Eestis! : eestin kielen alkeisoppikirja = Estonian for beginners. Helsinki : Finn Lectura, 1999. 202 lk. + 1 helikassett. Õpik on mõeldud täiskasvanud õppijale, kes alustab eesti keele õppimist algtasemel

Britantsõ hotjat priiti v Latviju / Helga Balode, Mihhail Tuzhikov

Index Scriptorium Estoniae

Balode, Helga

2002-01-01

Briti transpordiminister jagas lätlastele raudtee erastamise kogemusi. Diagramm: Kaubavedu Baltimaade raudteedel. Vt. samas intervjuud Suurbritannia transpordiministri David Jamesoniga. Kommenteerib Anna Belova

Tarantino comes to the Tallinn stage / Joel Alas

Index Scriptorium Estoniae

Alas, Joel

2007-01-01

Vene Teatris 14. aug. esietenduva Quentin Tarantino filmistsenaariumil "Marukoerad" ("Reservoir Dogs") põhinevat lavastust (lavastaja Anna Trifonova) tutvustab Liidia Kaljundi. Ka Tarantino kultusfilmist

Priglashenije v Russki teatr / Jelena Skulskaja

Index Scriptorium Estoniae

Skulskaja, Jelena, 1950-

2007-01-01

5. septembril kutsutakse huvilisi Vene Teatrisse vaatama Quentin Tarantino filmistsenaariumil "Marukoerad" ("Reservoir Dogs") põhinevat Anna Trifonova lavastust ning peale lavastust osalema vestlusringis

Anna's Story of Life in Prison

Science.gov (United States)

Boodle, Anna; Ellem, Kathy; Chenoweth, Lesley

2014-01-01

People with an intellectual disability in prison can be at increased risk of victimisation, segregation and isolation (Mullen ). Prison systems usually have very few resources to cater to this group's particular needs, and many people may re-enter the community with little or no rehabilitation, poor social connections, poor mental health and…

Putin predlozhil Nikite rabotu / Anna Skvortsova

Index Scriptorium Estoniae

Skvortsova, Anna

2001-01-01

Moskva XXIII rahvusvahelise filmifestivali külaliseks olnud Hollywoodi kuulsused Jack Nicholson, Sean Penn ja mitmed teised tuntud vene ja välismaa filmiinimesed kohtusid Venemaa presidendi Vladimir Putiniga Nikita Mihhalkovi suvilas

VITSH vlijajet na moral / Anna Litvinjuk

Index Scriptorium Estoniae

Litvinjuk, Anna

2006-01-01

Vestlusest Eesti Seksuaaltervise Liidu noorte reproduktiivtervise alase nõustamise ja sugulisel teel levivate haiguste ennetamise programmi juhi Tiia Perteliga, kes osales hiljuti Torontos toimunud AIDSI-teemalisel rahvusvahelisel konverentsil

Moekunstniku katsetused kinolinal / Anna-Liisa Soomann

Index Scriptorium Estoniae

Soomann, Anna-Liisa

2007-01-01

Taani moekunstniku Mads Nırgaardi filmidebüüt Kopenhaageni moenädalal. Film tutvustab kunstniku moekollektsiooni, kaasa teevad taani supermodellid Freja Beha ja Eddie Merz, muusika DJ Djuna Barnes'ilt

Moda zajavljajet o sebe / Anna Korjakina

Index Scriptorium Estoniae

Korjakina, Anna

2005-01-01

Balti Moeföderatsiooni organiseeritud Riia moenädalast, kus oma töid demonstreerisid Läti, Eesti, Leedu, Venemaa ja Prantsusmaa moeloojad. Eestist Oksana Tandit ja Triinu Pungits. Pikemalt Masha Tsigali kollektsioonist (Venemaa)

Ljubov nebessnaja i zemnaja / Anna Moleva

Index Scriptorium Estoniae

Moleva, Anna

2002-01-01

Venemaa teleseriaali "Vene amatsoonid" ("Russkije amazonki") võtteplatsil vastavad küsimustele režissöör Isaak Fridberg, näitlejad Leonid Jakubovitsh, Juozas Budraitis, Aleksei Krivtshenko ja Irina Rozanova

Ilvese aasta 2009 / Iivi Anna Masso

Index Scriptorium Estoniae

Masso, Iivi, 1967-

2009-01-01

President Toomas Hendrik Ilvese kandideerimisest Euroopa Liidu Ülemkogu presidendi kohale, Eesti riigipea säravatest esinemistest välismaal, sõnavõttudest demokraatia, kodanikuühiskonna ja inimõiguste kaitsel, Eesti meedia kõrgendatud tähelepanust presidendi abikaasa tegemiste suhtes

Trebujutsja Minin i Pozharski / Anna Hrustaljova

Index Scriptorium Estoniae

Hrustaljova, Anna

2004-01-01

Vene filmifestival "Moskovskaja premjera" ja seal esile tõstetud filmid : "Shiza" ( režissöör Gulshad Omarova), "Pikk hüvastijätt" ("Dolgoje proshtshanije"), parima režissööri tiitli saanud Sergei Ursuljak)

Kuulus film algversioonis tagasi

Index Scriptorium Estoniae

2005-01-01

Veebruaris esilinastus Berliini filmifestivalil Sergei Eisensteini 1925.a. valminud filmi võimalikult originaalilähedaseks taastatud versioon (restaureerijad saksa filmiajaloolased Anna Bohn ja Enno Patalas)

Systematic Functional Characterization of Resistance to PI3K Inhibition in Breast Cancer.

Science.gov (United States)

Le, Xiuning; Antony, Rajee; Razavi, Pedram; Treacy, Daniel J; Luo, Flora; Ghandi, Mahmoud; Castel, Pau; Scaltriti, Maurizio; Baselga, Jose; Garraway, Levi A

2016-10-01

PIK3CA (which encodes the PI3K alpha isoform) is the most frequently mutated oncogene in breast cancer. Small-molecule PI3K inhibitors have shown promise in clinical trials; however, intrinsic and acquired resistance limits their utility. We used a systematic gain-of-function approach to identify genes whose upregulation confers resistance to the PI3K inhibitor BYL719 in breast cancer cells. Among the validated resistance genes, Proviral Insertion site in Murine leukemia virus (PIM) kinases conferred resistance by maintaining downstream PI3K effector activation in an AKT-independent manner. Concurrent pharmacologic inhibition of PIM and PI3K overcame this resistance mechanism. We also observed increased PIM expression and activity in a subset of breast cancer biopsies with clinical resistance to PI3K inhibitors. PIM1 overexpression was mutually exclusive with PIK3CA mutation in treatment-naïve breast cancers, suggesting downstream functional redundancy. Together, these results offer new insights into resistance to PI3K inhibitors and support clinical studies of combined PIM/PI3K inhibition in a subset of PIK3CA-mutant cancers. PIM kinase overexpression confers resistance to small-molecule PI3K inhibitors. Combined inhibition of PIM and PI3K may therefore be warranted in a subset of breast cancers. Cancer Discov; 6(10); 1134-47. ©2016 AACR.This article is highlighted in the In This Issue feature, p. 1069. ©2016 American Association for Cancer Research.

Four MicroRNAs Promote Prostate Cell Proliferation with Regulation of PTEN and Its Downstream Signals In Vitro

Science.gov (United States)

Xue, Jing-lun; Chen, Jin-zhong

2013-01-01

Background Phosphatase and tensin homologue (PTEN), as a tumor suppressor, plays vital roles in tumorigenesis and progression of prostate cancer. However, the mechanisms of PTEN regulation still need further investigation. We here report that a combination of four microRNAs (miR-19b, miR-23b, miR-26a and miR-92a) promotes prostate cell proliferation by regulating PTEN and its downstream signals in vitro. Methodology/Principal Findings We found that the four microRNAs (miRNAs) could effectively suppress PTEN expression by directly interacting with its 3’ UTR in prostate epithelial and cancer cells. Under-expression of the four miRNAs by antisense neutralization up-regulates PTEN expression, while overexpression of the four miRNAs accelerates epithelial and prostate cancer cell proliferation. Furthermore, the expression of the four miRNAs could, singly or jointly, alter the expression of the key components in the phosphoinositide 3-kinase (PI3K)/Akt pathway, including PIK3CA, PIK3CD, PIK3R1 and Akt, along with their downstream signal, cyclin D1. Conclusions These results suggested that the four miRNAs could promote prostate cancer cell proliferation by co-regulating the expression of PTEN, PI3K/Akt pathway and cyclin D1 in vitro. These findings increase understanding of the molecular mechanisms of prostate carcinogenesis and progression, even provide valuable insights into the diagnosis, prognosis, and rational design of novel therapeutics for prostate cancer. PMID:24098737

Substantiation of the TVR-M reactor parameter selection and specific features of the research program

International Nuclear Information System (INIS)

Abov, Yu.G.; Kiselev, G.V.; Shvedov, O.V.

1986-01-01

Comparative analysis of characteristics of the T-VR-M(ITEP, USSR), GRHF(France) and PIK(LNPI USSR) high-flux heavy water cooled and moderated research reactors is given. The TVR-M reactor design concepts are mainly based on a 35-year experience in operating of the first Soviet heavy water research TVR reactor. As a result of the reactor reconstruction its thermal power will increase up to 25 MW neutron flux in experimental channels will increase 10 fold and reach 5.6x10 14 neutron/cm 2 xc. The TVR-M reactor has the quality value the ratio of maximum thermal neutron flux value the reflector to reactor power in practically the same as for the GRHF reactor (2.24x10 13 (neutron/cm 2 xc)/MW) which allows one to place it among the best research reactors in the world. Maximum fuel burnup of the order of 50% and minimum fuel loading are forseen for the TVR-M reactor which provides for operation cost minimum as compared to the GRHF and PIK reactors. The TVR-M reactor practically does not yield to the PIK and GRMF reactors in experimental channel quantity and exceeds the in the number of vertical channels. The TVR-M reactor experimental capabilities allow one to reduce measuring time and provide for conducting the experiments at a qualitatively new level. At the same time capabilities of radioactive nuclide production in qualitative and quantitative senses are increased

Tus acciones te delatan: ¿Es el sistema cognitivo sensible a los parámetros cinemáticos de las acciones con distintas intenciones?

Directory of Open Access Journals (Sweden)

Rocío Goñi Cabara

2016-11-01

Full Text Available George es un tenista que en este momento se encuentra a instantes de realizar un smash para rematar un partido. Anna, por su parte, está en la cacería de un inoportuno insecto volador utilizando una raqueta eléctrica. Si detuviésemos el tiempo en el instante en que George y Anna alzan sus brazos, sin acceder al contexto en el que la acción tiene lugar, ¿seríamos capaces de detectar la intención que subyace a cada movimiento? Estudios recientes sugieren que esto es posible a partir del análisis de la velocidad y trayectoria de acciones que, a primera vista, parecen idénticas.

Exploring trust in online health information: a study of user experiences of patients.co.uk.

Science.gov (United States)

Cunningham, Anna; Johnson, Frances

2016-12-01

This feature has been co-authored by Anna Cunningham and her supervisor Frances Johnson. It is based on the research Anna conducted for her dissertation, which she completed as part of her MA in Library and Information Management at Manchester Metropolitan University. The study explored how people assess the trustworthiness of online health information, and the participants were asked to talk aloud whilst viewing information on the consumer health information website patients.co.uk. The study confirmed that their assessment was based on the information usefulness and credibility as well as identifying the factors relating to information quality and website design that helped to form these judgements. A. M. © 2016 Health Libraries Group.

Electrostatic Charge on Flying Hummingbirds and Its Potential Role in Pollination.

Science.gov (United States)

Badger, Marc; Ortega-Jimenez, Victor Manuel; von Rabenau, Lisa; Smiley, Ashley; Dudley, Robert

2015-01-01

Electrostatic phenomena are known to enhance both wind- and insect-mediated pollination, but have not yet been described for nectar-feeding vertebrates. Here we demonstrate that wild Anna's Hummingbirds (Calypte anna) can carry positive charges up to 800 pC while in flight (mean ± s.d.: 66 ± 129 pC). Triboelectric charging obtained by rubbing an isolated hummingbird wing against various plant structures generated charges up to 700 pC. A metal hummingbird model charged to 400 pC induced bending of floral stamens in four plants (Nicotiana, Hemerocallis, Penstemon, and Aloe spp.), and also attracted falling Lycopodium spores at distances of < 2 mm. Electrostatic forces may therefore influence pollen transfer onto nectar-feeding birds.

Välieluruumi ajakiri Õu = Õu, the Landscape Architecture Magazine

Index Scriptorium Estoniae

2016-01-01

Välieluruumi ajakirjast "Õu", peatoimetaja Anna-Liisa Unt, kolleegium Merle Karro-Kalberg ja Karin Bachmann, kujundaja Marje Eelmaa (Tuumik Stuudio). Maastikuarhitektuuri aastapreemia 2016 "Maastikuarhitektuuri tegu" laureaat

Näitused / Katrin Kurik

Index Scriptorium Estoniae

Kurik, Katrin

1998-01-01

Linnagalerii Tallinnas: Anna Pauli tekstiilid ja Andras Huberi skulptuurid (Ungari); Kullo lastegalerii: Heli Männi ja Tondiraba keskkooli kunstiklasside õpilaste "Veneetsia maskid"; Tammsaare majamuuseum: Kersti Karu keraamika

Winter range expansion of a hummingbird is associated with urbanization and supplementary feeding

Science.gov (United States)

Wood, Eric M.

2017-01-01

Anthropogenic changes to the landscape and climate cause novel ecological and evolutionary pressures, leading to potentially dramatic changes in the distribution of biodiversity. Warm winter temperatures can shift species' distributions to regions that were previously uninhabitable. Further, urbanization and supplementary feeding may facilitate range expansions and potentially reduce migration tendency. Here we explore how these factors interact to cause non-uniform effects across a species's range. Using 17 years of data from the citizen science programme Project FeederWatch, we examined the relationships between urbanization, winter temperatures and the availability of supplementary food (i.e. artificial nectar) on the winter range expansion (more than 700 km northward in the past two decades) of Anna's hummingbirds (Calypte anna). We found that Anna's hummingbirds have colonized colder locations over time, were more likely to colonize sites with higher housing density and were more likely to visit feeders in the expanded range compared to the historical range. Additionally, their range expansion mirrored a corresponding increase over time in the tendency of people to provide nectar feeders in the expanded range. This work illustrates how humans may alter the distribution and potentially the migratory behaviour of species through landscape and resource modification. PMID:28381617

Fellowship | Indian Academy of Sciences

Indian Academy of Sciences (India)

Address: Senior Research Scientist, International Centre for Theoretical Physics, 11, ..... Specialization: Electronics, Controls and Nuclear Power .... Address: Director - Research, Aravind Medical Research Foundation, 1, Anna Nagar, Madurai ...

Learning about Your Disease

Science.gov (United States)

... however you can Daughter's dying wish became mother's motivation Be The Match Blog Stories Anna, transplant recipient ... Copyright © 1996-2018 National Marrow Donor Program. All Rights Reserved.

What Is a Bone Marrow Transplant?

Science.gov (United States)

... however you can Daughter's dying wish became mother's motivation Be The Match Blog Stories Anna, transplant recipient ... Copyright © 1996-2018 National Marrow Donor Program. All Rights Reserved.

Life After Transplant

Science.gov (United States)

... however you can Daughter's dying wish became mother's motivation Be The Match Blog Stories Anna, transplant recipient ... Copyright © 1996-2018 National Marrow Donor Program. All Rights Reserved.

Pildimängude dünaamika : Tommy & Laurentsius Matti Miliuse kunstikogust / Mariann Raisma

Index Scriptorium Estoniae

Raisma, Mariann, 1974-

1998-01-01

Retrospektiivnäitus Tartu Kunstimajas. Kunstnikud jätkavad ka praegu nn. kunstnike tandemi traditsiooni, Laurentsius ehk Lauri Sillak Anna-Daniela Saalistega, Tommy ehk Toomas Tõnissoo Kadri Kangilaskiga.

Molecular alterations and clinical prognostic factors for cholangiocarcinoma in Thai population

Directory of Open Access Journals (Sweden)

Trachu N

2017-10-01

Full Text Available N Trachu,1,2 E Sirachainan,3 N Larbcharoensub,4 W Rattanadech,3 S Detarkom,3 N Monnamo,1 K Kamprerasart,4 D MunTham,5 C Sukasem,6,7 T Reungwetwattana3 1Research Center, Faculty of Medicine Ramathibodi Hospital, 2Molecular Medicine Program, Multidisciplinary Unit, Faculty of Science, 3Division of Medical Oncology, Department of Medicine, 4Division of Anatomical Pathology, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 5Section for Mathematic, Faculty of Science and Technology, Rajamangala University of Technology Suvarnabhumi, 6Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, 7Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand Abstract: This study explores genomic alterations in cholangiocarcinoma (CCC tissues in Thai patients. We identified and reviewed the records of patients who had been diagnosed with CCC and for whom sufficient tumor samples for DNA and RNA extraction were available in our database. The specimens were explored for EGFR, KRAS, BRAF, and PIK3CA mutations and ROS1 translocation in 81 samples. Immunohistochemistry staining for HER2, ALK, and Ki-67 expression was tested in 74 samples. Prevalence of EGFR, KRAS, and PIK3CA mutations in this study was 21%, 12%, and 16%, respectively. No BRAF V600 mutation or ROS1 translocation was found. Patients with T790M mutation had a significantly longer overall survival (18.84 months than those with the other types of EGFR mutations (4.08  months; hazard ratio [HR]: 0.26, P=0.038 and also had a significantly lower median Ki-67 (22.5% vs 80%, P=0.025. Furthermore, patients with PIK3CA mutations had a significantly longer median progression-free survival (15.87 vs 7.01 months; HR: 0.46, P=0.043. Strongly positive HER2 expression was found in only 1 patient, whereas ALK expression was not found. The presence of EGFR

Trastuzumab anti-tumor efficacy in patient-derived esophageal squamous cell carcinoma xenograft (PDECX mouse models

Directory of Open Access Journals (Sweden)

Wu Xianhua

2012-08-01

Full Text Available Abstract Background Trastuzumab is currently approved for the clinical treatment of breast and gastric cancer patients with HER-2 positive tumors, but not yet for the treatment of esophageal carcinoma patients, whose tumors typically show 5 ~ 35% HER-2 gene amplification and 0 ~ 56% HER-2 protein expression. This study aimed to investigate the therapeutic efficacy of Trastuzumab in patient-derived esophageal squamous cell carcinoma xenograft (PDECX mouse models. Methods PDECX models were established by implanting patient esophageal squamous cell carcinoma (ESCC tissues into immunodeficient (SCID/nude mice. HER-2 gene copy number (GCN and protein expression were determined in xenograft tissues and corresponding patient EC samples by FISH and IHC analysis. Trastuzumab anti-tumor efficacy was evaluated within these PDECX models (n = 8 animals/group. Furthermore, hotspot mutations of EGFR, K-ras, B-raf and PIK3CA genes were screened for in the PDECX models and their corresponding patient’s ESCC tissues. Similarity between the PDECX models and their corresponding patient’s ESCC tissue was confirmed by histology, morphology, HER-2 GCN and mutation. Results None of the PDECX models (or their corresponding patient’s ESCC tissues harbored HER-2 gene amplification. IHC staining showed HER-2 positivity (IHC 2+ in 2 PDECX models and negativity in 3 PDECX models. Significant tumor regression was observed in the Trastuzumab-treated EC044 HER-2 positive model (IHC 2+. A second HER-2 positive (IHC 2+ model, EC039, harbored a known PIK3CA mutation and showed strong activation of the AKT signaling pathway and was insensitive to Trastuzumab treatment, but could be resensitised using a combination of Trastuzumab and AKT inhibitor AZD5363. In summary, we established 5 PDECX mouse models and demonstrated tumor regression in response to Trastuzumab treatment in a HER-2 IHC 2+ model, but resistance in a HER-2 IHC 2+/PIK3CA mutated model. Conclusions

Twilio Eesti büroo = Offices of Twilio Estonia / Katrin Kaevats ; kommenteerinud Ann Koljang

Index Scriptorium Estoniae

Kaevats, Katrin, 1980-

2016-01-01

Rahvusvahelise ettevõtte Twilio Eesti büroo Tallinnas, Veerenni tn. 24. Sisekujunduse autorid Katrin Kaevats, Jaan Port, Markus Nimik, Neeme Tiimus, Anna Nikland. Büroohoone projekteerisid PIN Arhitektid

Шекспир ответит на вопрос: семья и/или карьера? / Ксения Репсон

Index Scriptorium Estoniae

Репсон, Ксения

2011-01-01

Performance "Sürr Shakespeare", osalejateks Vene Teatrikool (Tallinn), Teater-stuudio SPbGU (Peterburi), Teatristuudio Mad Mix (Potsdam). Paralleelselt performance’iga loob kunstnik AnnA egida (Moskva) reaalajas graafilise teose

Russki teatr gotovit letnije projektõ / Ksenia Repson

Index Scriptorium Estoniae

Repson, Ksenia

2007-01-01

Enne Vene Teatri 59. hooaja ametlikku algust mängitakse augustis mitmeid teatri lavastusi ning 14. aug. esietendub Quentin Tarantino filmistsenaariumil "Marukoerad" ("Reservoir Dogs") põhinev Anna Trifonova lavastus

Sadhana | Indian Academy of Sciences

Indian Academy of Sciences (India)

The nonlinear connector elements are used to model the rolling elements. ... Department of Mechanical Engineering, Anna University Tirunelveli Region, ... Centre for Manufacturing Sciences National Engineering College, Kovilpatti 628503, ...

Krishnamoorthy, Prof. Guruswamy

Indian Academy of Sciences (India)

Address: Honorary Professor, Department of Biotechnology, Anna University, Guindy, Chennai 600 025, T.N.. Contact: ... Summer Research Fellowship Programme 2018. Posted on 21 ... Advanced Instructional School In Stochastic Processes.

Presidentti Toomas Hendrik Ilves arvostelee HS:n Viro-uutisointia / Kaja Kunnas

Index Scriptorium Estoniae

Kunnas, Kaja

2011-01-01

President Toomas Hendrik Ilvese väljendatud kriitikast ajalehe Helsingin Sanomat suhtes. Ajalehe Diplomaatia peatoimetaja Iivi Anna Masso ja kultuuriminister Rein Lang on samuti kritiseerinud Eesti kajastamist Soome meedias

Energy fluxes and spectra for turbulent and laminar flows

KAUST Repository

Verma, Mahendra K.; Kumar, Abhishek; Kumar, Praveen; Barman, Satyajit; Chatterjee, Anando G.; Samtaney, Ravi

2017-01-01

spectrum $E(k)$ and energy flux $\\Pi(k)$ using spectral simulations on grids up to $4096^3$, and show consistency between the numerical results and predictions by the aforementioned models. We also construct a model for laminar flows that predicts $E(k

Trikotazh / Irina Kuzina

Index Scriptorium Estoniae

Kuzina, Irina

2006-01-01

ERKI moeshow Tallinnas Vene Kultuurikeskuses. Eesti osalejatest nimetatud Anna Roometit ja Marta Kisandit ning Vassilissa Danaviri ja nende kollektsioone. Pealkirja all "Jantarnaja komnata Oksanõ Tandit" Oksana Tanditi uuest kollektsioonist

Kleeppildid seksuaalse sättumuse eri tahkudest

Index Scriptorium Estoniae

2011-01-01

Kunstifestivali Lift 2011 raames esitletakse 13. juulil Tallinnas Märzi projektiruumis kunstnike ja aktivistide loodud "Queer-kleepekakogu". Vestlusringis osalevad kuraatorid-kunstnikud Anna-Stina Treumund ja Jaanus Samma ning kleeppiltide autorid

Bagatellid : maailm / Nele-Eva Steinfeld

Index Scriptorium Estoniae

Steinfeld, Nele-Eva

2008-01-01

Suri pianist Aleksandr Slobodjanik. Opera News jagas preemiaid. Ajulained kohtuvad helilainetega. Luciano Pavarotti mälestus. Stradivari tšello oksjonil. Õuduslugu "Kärbes" uues ooperikuues. Anna Netrebko tagasitulek

Анна Дубровская между небом и землей / Анна Дубровская ; интервьюировал Николай Караев

Index Scriptorium Estoniae

Дубровская, Анна, 1972-

2010-01-01

Teatrifestivalil "Kuldne Mask Eestis" etendus Anton Tšehhovi "Onu Vanja", lavastaja Rimas Tuminas, Moskva Jevgeni Vahtangovi nimeline Teater. Intervjuu Jelena Andrejevnat mängiva Anna Dubrovskajaga tema elust ja rollidest

The Role of Trust in Participatory Processes

OpenAIRE

Dobrova, Anna

2017-01-01

von Anna Dobrova Arbeit an der Bibliothek noch nicht eingelangt - Daten nicht geprueft Abweichender Titel nach Übersetzung der Verfasserin/des Verfassers Technische Universität Wien, Univ., Diplomarbeit, 2017

EPRI/DOE High-Burnup Fuel Sister Rod Test Plan Simplification and Visualization

Energy Technology Data Exchange (ETDEWEB)

Saltzstein, Sylvia J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Sorenson, Ken B. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hanson, B. D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Shimskey, R. W. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Klymyshyn, N. A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Webster, R. A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Jensen, P. J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); MacFarlan, P. J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Billone, Mike [Argonne National Lab. (ANL), Argonne, IL (United States); Scaglione, John [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Montgomery, Rose [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bevard, Bruce [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

2017-09-15

The EPRI/DOE High-Burnup Confirmatory Data Project (herein called the “Demo”) is a multi-year, multi-entity test with the purpose of providing quantitative and qualitative data to show if high-burnup fuel mechanical properties change in dry storage over a ten-year period. The Demo involves obtaining 32 assemblies of high-burnup PWR fuel of common cladding alloys from the North Anna Nuclear Power Plant, loading them in an NRC-licensed TN-32B cask, drying them according to standard plant procedures, and then storing them on the North Anna dry storage pad for ten years. After the ten-year storage time, the cask will be opened and the mechanical properties of the rods will be tested and analyzed.

Electrostatic Charge on Flying Hummingbirds and Its Potential Role in Pollination.

Directory of Open Access Journals (Sweden)

Marc Badger

Full Text Available Electrostatic phenomena are known to enhance both wind- and insect-mediated pollination, but have not yet been described for nectar-feeding vertebrates. Here we demonstrate that wild Anna's Hummingbirds (Calypte anna can carry positive charges up to 800 pC while in flight (mean ± s.d.: 66 ± 129 pC. Triboelectric charging obtained by rubbing an isolated hummingbird wing against various plant structures generated charges up to 700 pC. A metal hummingbird model charged to 400 pC induced bending of floral stamens in four plants (Nicotiana, Hemerocallis, Penstemon, and Aloe spp., and also attracted falling Lycopodium spores at distances of < 2 mm. Electrostatic forces may therefore influence pollen transfer onto nectar-feeding birds.

Aliocha Dostoevski’s death during an epileptic seizure

Directory of Open Access Journals (Sweden)

Edson José Amâncio

Full Text Available ABSTRACT Mortality due to epilepsy is of great concern worldwide. Individuals with epilepsy have a two- or three-fold risk of death when compared to the general population. Based on biographical data and Anna Grigoriévna Dostoevskaia’s memories, the authors concluded that a prolonged episode of status epilepticus was the culprit in the death of young Aliocha, youngest son of Fyodor Mikhailovich and Anna Dostoevski. At the time of Aliocha’s death, very limited knowledge about epilepsy or therapeutic resources was available. Despite all the progress, epilepsies remain potentially fatal conditions. The suffering generated by Aliocha’s death and other similar cases remains as a challenge for epileptologists who assemble efforts to fight against such conditions.

Hillary Clinton sai kolmes osariigis valusalt lüüa / Heiki Suurkask

Index Scriptorium Estoniae

Suurkask, Heiki, 1972-

2008-01-01

USA presidendi eelvalimistel võitis Barack Obama oma pearivaali Hillary Clintonit nii Louisianas, Nebraskas kui Washingtonis ja sisuliselt viigistas üleriigilise parteidelegaatide arvestuse. Vt. samas: Huckabee ei anna ikka veel alla

76 FR 68467 - Medicare and Medicaid Programs; Quarterly Listing of Program Issuances-April Through June 2011

Science.gov (United States)

2011-11-04

... Stuart Caplan, (410) 786-8564 Emission Tomography Registry RN, MAS. Sites. XII Medicare-Approved JoAnna... Stuart Caplan, (410) 786-8564 Emission Tomography for RN, MAS. Dementia Trials. All Other Information...

Mida arvasid väliskülalised ?

Index Scriptorium Estoniae

2006-01-01

Saksa teatrikriitik ja teatripedagoog Manfred Jahnke, Turu Rakenduskõrgkooli Kunstiakadeemia nukukunsti õppetooli juhataja Anna Ivanova-Brashinskaya ja Praha teatri Minor stsenarist ja dramaturg Petra Zamecnikova Eesti laste- ja noorteteatri festivalist "Draamake"

Animatsioon ei hammusta

Index Scriptorium Estoniae

2005-01-01

IX Pimedate Ööde Filmifestivali alafestival "Animated Dreams" ja seal esinevad külalised : tšehhi animaator Michaela Pavlatova, Chris J. Robinson Kanadast, Anna Doyle Suurbritanniast. Lisatud animafestivali ajakava

Vaprad lucky loser'id / Jüri Aarma ; kommenteerinud Tanja Muravskaja

Index Scriptorium Estoniae

Aarma, Jüri, 1951-

2009-01-01

Tanja Muravskaja isikunäitus "Lucky Losers" Tallinna Linnagaleriis. Eksponeeritud videoportreed vene rahvusest Eesti kodanikest Dimitri Klenskist, Adolf Käisist, Anna Levandist, Tatjana Muravjovast, Mihhail Stalnuhhinist, Eduard Tomanist ja Boris Tuchist

Uurali mütoloogiate avaköide tutvustab komide maailmapilti / Nikolay Kuznetsov

Index Scriptorium Estoniae

Kuznetsov, Nikolay

2006-01-01

Arvustus: Komi Mythology : Encyclopaedia of Uralic Mythologies. 1. / toim. Vladimir Napolskikh, Anna-Leena Siikala, Mihály Hoppál. Budapest : Akadémiai Kiadó ; Helsinki : Finnish Literature Society, 2003

Baletnaja poezija erotiki / Boris Eifman ; interv. Aljona Strizhenova

Index Scriptorium Estoniae

Eifman, Boris, 1946-

2007-01-01

Lev Tolstoi romaani "Anna Karenina" järgi Boris Eifmani loodud koreograafiaga balletilavastus Pjotr Tšaikovski muusikale. B. Eifmani nim. St-Peterburgi Riikliku Akadeemilise Balletiteatri külalisetendused Tallinnas, 16. juunil

Kelomehele preemia Baseli festivalil

Index Scriptorium Estoniae

2000-01-01

Baselis festivalil "VIPER - International Festival for Film Video and New Media" tunnistati parimaks CD-ROMiks Gustav Deutschi/Anna Schimeki "Odysee today", netiprojektiks itaallaste "01.ORG", äramärkimispreemia - Raivo Kelomehe "Videoweaver"

Kui hea pressifoto on hea kunst = Good press photography as good art / Anneli Porri

Index Scriptorium Estoniae

Porri, Anneli, 1980-

2012-01-01

Pressifoto ja kaasaegse kunsti seostest, pressifotost ja fotokunstist. Erik Prozese fotost "Minister, anna aru!" ja fotoseeriast "Eesti portreed taldrikutel", Andres Puttingu fotoseeriast "Suusakuninga tõehetk", Andres Haabu fotost "Lahing pooltühjas kinosaalis"

Natural fabric sandwich laminate composites: development and ...

Indian Academy of Sciences (India)

3Department of Production Technology, MIT Campus, Anna University, Chennai 600044, India. MS received ... In this work, eco-friendly natural fabric sandwich laminate (NFSL) composites are formulated using ... and eco-friendly quality [22].

Meie esimesed naisfotograafid / Annika Haas

Index Scriptorium Estoniae

Haas, Annika, 1974-

2016-01-01

Tallinna fotomuuseumi aastanäitus "Varjust välja. Esimesed naisfotograafid Eestis", kuraatorid Betty Ester-Väljaots, Merili Reinpalu, kunstnik Lilian Juhkam. Eesti naisfotograafide Anna Kuke ja Evi Lembergi eluloolisi andmeid, nende looming

Abieluakti koostamine EELKs - õigus või kohustus? / Merje Talvik

Index Scriptorium Estoniae

Talvik, Merje

2008-01-01

Vaimulike õigusest pärast siseministeeriumi korraldatava koolituse läbimist riigi nimel abielu sõlmida. Kommenteerivad Kristjan Luhamets, Rein Schihalejev, Mare Palgi, Illimar Toomet, Mart Jaanson, Anna-Liisa Vaher ja Kalle Gaston

Molecular Profiles for Lung Cancer Pathogenesis and Detection in U.S. Veterans

Science.gov (United States)

2013-10-01

independent survival and growth of cancer cells, including a catalytic subunit of phosphatidylinositol 3- kinase (PIK3CA) (33) and the SH2 -containg...comparative genomic hybridization: implications of the phosphatidylinositol 3- kinase pathway. Cancer Res. 2002;62:3636-40. 28. Massion PP, Zou Y, Uner

Época de maduración y calidad del fruto de genotipos de manzana en Cadereyta, Qro

Directory of Open Access Journals (Sweden)

S. Mendoza-González

2008-01-01

Full Text Available La manzana en Querétaro se produce bajo temporal y en pendientes pronunciadas, lo que aunado al deficiente manejo de los huertos, la presencia de eventos climatológicos y la estacionalidad de producción de las principales variedades cultivadas, propicia que la fruta sea de mala calidad y de difícil comercialización. Una alternativa es la introducción y selección de variedades de mejor calidad, adaptadas a las condiciones locales y de maduración temprana. Se estudió la época de maduración y la calidad del fruto de 20 nuevos híbridos y cultivares de manzano con base en el diámetro ecuatorial, peso, firmeza, sólidos solubles totales (SST y acidez total titulable (ATT. Los genotipos 401 ("Tropical Beauty" x "Princesa", de color rojo y 467 ("Anna" x "Liberty", amarilla resultaron los más tempranos en maduración del fruto (8 de julio; otros seis genotipos ("Rayada", 424, 428, 421, SM4 y SM5 maduraron antes de agosto. El material de mayor tamaño fue 428 ("Anna" x "Gala", chapeada, con 8.5 cm de diámetro y 39 % de frutos en la categoría "Extra" de acuerdo con la norma mexicana. Otros genotipos sobresalientes en cuanto a tamaño fueron 467 (7.0 cm y "Rayada" (6.9 cm. Entre los materiales de maduración intermedia, destacan 436 ("Anna" x "Gala" y 429 ("Anna" x CLR9T10 y superan en diámetro a "Golden Delicious" con 7.8 cm. y 7.5 cm, respectivamente. Además, la primera produjo 27 % de los frutos en la categoría ¿Extra¿ y una concentración de SST (16.3 % superior a "Golden Delicious" (13.4 % y "Red Delicious" (12.7 %. Entre los genotipos tardíos, "Lourdes" mostró una calidad similar a la de los cultivares locales.

Ne/zhenskii put karjerõ / Anna Litvinjuk

Index Scriptorium Estoniae

Litvinjuk, Anna

2007-01-01

Termin "glass ceiling" (klaaslagi) võeti kasutusele USA-s umbes paarkümmend aastat tagasi, nii nimetasid uurijad kunstlikult loodud nähtamatut, kuid läbimatut takistust karjääriredelil liikujaile. Sagedamini kasutatakse terminit, kui juttu tuleb ühiskonnas ja äris eksisteerivast diskrimineerimisest soolise või rahvusliku tunnuse järgi. Eestis astutakse esimesi samme soolise võrdsuse tagamiseks, 2004. aastal läbi viidud uuringu tulemustest

Ettevaatust! Nüüdistants / Anna-Liisa Villmann

Index Scriptorium Estoniae

Villmann, Anna-Liisa

2010-01-01

11. Augusti Tantsufestivalist Tallinnas. Lühidalt Ele Viskuse etendusest "Taidlusrühm Rähn", Liis Ilula etendusest "Älis mnimedemaal", Henri Hüti etendusest "The reader", Mihkel Ernitsa vabaõhuetendusest "Kehanäppajad". Brüsseli nüüdistantsu kooli P.A.R.T.S. etendustest. Samas 14.-28. augustini kestva festivali kavast

Anna Wintour: The Truth behind the Bob

Science.gov (United States)

Kloeppel, Tara

2011-01-01

While her occupation, and the stereotypes associated with running a fashion magazine, may not initially seem to be worthy of scholastic attention, careful study of Wintour's influence reveals insight into the rhetorical tactics penetrating fashion culture in America, and perhaps more broadly, pop culture in America.

Die Zitate in der Alexias Anna Komnenes

Directory of Open Access Journals (Sweden)

Diether Roderich REINSCH

1998-09-01

Full Text Available   Diether  Roderich  Reinch Τα  παραθέματα   στην   Ἀλεξιάδα της  Άννας ΚομνηνήςΤα τελευταία χρόνια η μελέτη των παραθεμάτων έχει δείξει την ανάγκη απεμπλοκής από την απλή ένδειξη των φιλολογικών παραλλήλων στο υπόμνημα πηγών, όπως αυτό παρατίθεται στις κριτικές εκδόσεις βυζαντινών κειμένων. Η ανάλυση παραθεμάτων από τον Όμηρο και την Καινή Διαθήκη που χρησιμοποιούνται από την Άννα Κομνηνή στην Ἀλεξιάδα υποδεικνύει ότι η συγγραφεύς χειρίζεται ελεύθερα τις πηγές της διασκευάζοντας, παραφράζοντας και προσαρμόζοντάς τις ανάλογα με τις αφηγηματικές ανάγκες του κειμένου της. Οι αποκλίσεις, επομένως, από το αυθεντικό κείμενο δεν μαρτυρούν σύγχυση, αλλά συνειδητή επεξεργασία.

Indiana protiv KGB / Anna Fedina, Pjotr Obraztsov

Index Scriptorium Estoniae

Fedina, Anna

2008-01-01

Steven Spielbergi neljas Indiana Jones'i film Harrison Fordiga nimiosas "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull") : Ameerika Ühendriigid 2008

Kak zhurnalistõ vidjat Estoniju / Anna Litvinjuk

Index Scriptorium Estoniae

Litvinjuk, Anna

2006-01-01

2005. aasta parimate pressifotode näitusest Vaal-galeriis Tallinnas. Parima uudisfoto autor on üleriiklikus kategoorias Andras Kralla ja parima olemusfoto autor Raul Mee. Maakonnalehtede parimad on vastavalt Margus Ansu ja Sille Annuk. Kujundusauhinnad said suures kategoorias SL Õhtuleht ja väikeses kategoorias Järva Teataja

Brodvei na gastroljah v Estonii / Anna Litvinjuk

Index Scriptorium Estoniae

Litvinjuk, Anna

2003-01-01

26. apr. tähistab A. Ivashkevitshi stepptantsustuudio Duff-tap studio oma kümnendat tegevusaastat. Sel puhul on 26. ja 27. apr. Vene Draamateatris Jazz&Tapdance show, kuhu on kutsutud ka B. Duffy Ameerikast jt.

Aerial shaking performance of wet Anna's hummingbirds

Science.gov (United States)

Ortega-Jimenez, Victor Manuel; Dudley, Robert

2012-01-01

External wetting poses problems of immediate heat loss and long-term pathogen growth for vertebrates. Beyond these risks, the locomotor ability of smaller animals, and particularly of fliers, may be impaired by water adhering to the body. Here, we report on the remarkable ability of hummingbirds to perform rapid shakes in order to expel water from their plumage even while in flight. Kinematic performance of aerial versus non-aerial shakes (i.e. those performed while perching) was compared. Oscillation frequencies of the head, body and tail were lower in aerial shakes. Tangential speeds and accelerations of the trunk and tail were roughly similar in aerial and non-aerial shakes, but values for head motions in air were twice as high when compared with shakes while perching. Azimuthal angular amplitudes for both aerial and non-aerial shakes reached values greater than 180° for the head, greater than 45° for the body trunk and slightly greater than 90° for the tail and wings. Using a feather on an oscillating disc to mimic shaking motions, we found that bending increased average speeds by up to 36 per cent and accelerations of the feather tip up to fourfold relative to a hypothetical rigid feather. Feather flexibility may help to enhance shedding of water and reduce body oscillations during shaking. PMID:22072447

Snegurotshkad, plast ja punalipud ERKI moeshõul / Triin Thalheim

Index Scriptorium Estoniae

Thalheim, Triin, 1982-

2005-01-01

Sõna ja pildiga tutvustatakse Vene Kultuurikeskuses ERKI moeshõul esitatud Vassilissa, Kirill Safonovi, Kati Ilvese, Anna Roometi, Marte Kisandi, Pille Jürisoo, Karen Milistveri, Piret Paali, Erikka Bahnseni, Mikko Seppä, Hao Zhangi kollektsioone

Три крыши для классики: шатер, церковь, вокзал / Борис Тух

Index Scriptorium Estoniae

Тух, Борис, 1946-

2016-01-01

Kolmest 2016. a. suvelavastusest: "Suveöö unenägu" (Tallinna Linnateater, lav. Jaanus Rohumaa); "Becket ehk Jumala au" (Eesti Draamateater, lav. Priit Pedajas); "Anna Karenina" (R.A.A.A.M., lav. Vassili Pessegov)

Patients and families

Science.gov (United States)

... however you can Daughter's dying wish became mother's motivation Be The Match Blog Stories Anna, transplant recipient ... Jobs Job application FAQs E-Verify Career events Employee benefits About us Bea, transplant recipient Be The ...

Finding a Donor

Science.gov (United States)

... however you can Daughter's dying wish became mother's motivation Be The Match Blog Stories Anna, transplant recipient ... Jobs Job application FAQs E-Verify Career events Employee benefits About us Bea, transplant recipient Be The ...

Physical Health and Recovery

Science.gov (United States)

... however you can Daughter's dying wish became mother's motivation Be The Match Blog Stories Anna, transplant recipient ... Jobs Job application FAQs E-Verify Career events Employee benefits About us Bea, transplant recipient Be The ...

Rethinking Ethiopian Secured Transactions Law through ...

African Journals Online (AJOL)

Asress Adimi Gikay

Sant'Anna Pisa (SSSA), Piazza Martiri della Libertà, 33 56127 Pisa (Italia) C.F. ... progress-studies/studies/security-interests (Accessed 31 Jan. 17). ..... structure(s) of meaning, individual dispositions, institutional and power arrangements,.

The Niger Delta Crisis

African Journals Online (AJOL)

chifaou.amzat

2013-09-28

Sep 28, 2013 ... Department of History & International Studies, Delta State University, Abraka,. Nigeria. .... democracy implies popular power. That is ... Okonta (2006:5) draws attention to Anna Zalik's treatise called 'Petro-Vio- lence' and ...

Bolting state-building fault lines with social capital

African Journals Online (AJOL)

2013-12-15

Dec 15, 2013 ... distribution of power between contending social groups and social classes, on which ...... Boege, Volker, Anne Brown, Kevin Clements and Anna Nolan 2008. ... and social cohesion: Case studies from Cambodia and Rwanda.

Nõukogude Liidu kõige kaunimad näitlejannad : Kümme portreed ja lühikest biograafiat = Самые красивые актрисы Советского Союза : Десять портретов и кратких биографий

Index Scriptorium Estoniae

2009-01-01

Vene näitlejannade Irina Alferova, Anastassia Vertinskaja, Tatjana Doronina, Irina Mirošnitšenko, Ljubov Orlova, Tatjana Samoilova, Anna Samohhina, Svetlana Svetlitšnaja, Margarita Terehhova ja Natalja Fatejeva lühibiograafiad

Krabbe Disease (GLD)

Science.gov (United States)

... however you can Daughter's dying wish became mother's motivation Be The Match Blog Stories Anna, transplant recipient ... properly. Children with Krabbe disease have difficulty with memory, learning, speaking, understanding, and other mental functions. They ...

Audit : Galojan kulutas kolme kuuga toidule 56 000 krooni / Holger Roonemaa

Index Scriptorium Estoniae

Roonemaa, Holger

2008-01-01

MTÜ Eesti Euroopa Liikumine erakorraline üldkoosolek otsustas esitada liikumise endisele juhile Anna-Maria Galojanile 817 000 krooni suuruse nõude, auditi tulemuste kohaselt kõrvaldas eksjuht liikumise raha ligi 950 000 krooni eest

Graft-Versus-Host-Disease

Science.gov (United States)

... however you can Daughter's dying wish became mother's motivation Be The Match Blog Stories Anna, transplant recipient ... any symptoms of GVHD , tell your transplant doctor right away. Chronic GVHD: Usually develops 3-6 months ...

Magister = magister? / Arvo Meri

Index Scriptorium Estoniae

Meri, Arvo

2002-01-01

Vastavalt uuele kõrgharidusstandardile on magistriõpe üks osa kõrgharidusest, mille peaksid läbima enamik üliõpilastest. Magistriõppe läbimine enam teaduskraadi ei anna, see on spetsialistiõpe

Donation FAQs

Science.gov (United States)

... however you can Daughter's dying wish became mother's motivation Be The Match Blog Stories Anna, transplant recipient ... or by the patient's medical insurance, as are travel expenses and other non-medical costs. The only ...

Investigations on nucleation thermodynamical parameters of ...

Indian Academy of Sciences (India)

Author Affiliations. D P Paul1 R Jayavel2 C Subramanian2 P Ramasamy2. Department of Physics, University of Chittagong, Chittagong 1331, Bangladesh; Crystal Growth Centre, Anna University, Chennai 600 025, India ...

Mountaineering Tourism

Directory of Open Access Journals (Sweden)

Patrick Maher

2016-08-01

Full Text Available Reviewed: Mountaineering Tourism Edited by Ghazali Musa, James Higham, and Anna Thompson-Carr. Abingdon, United Kingdom: Routledge, 2015. xxvi + 358 pp. Hardcover. US$ 145.00. ISBN 978-1-138-78237-2.

Lexicographic Treatment of

African Journals Online (AJOL)

user

Thirdly, the macrostructure and microstructure of the dictionary should be ... Specific attention is given to the compilation of the amalgamated lemmalist focusing on .... Martin (ANNA: 25) distinguishes five different types of words relevant to.

Kohvik Supelsaksad = Supelsaksad Café

Index Scriptorium Estoniae

2011-01-01

Eesti Sisearhitektide Liidu 2010. a. söögikoha interjööri preemia pälvinud kohvikust Supelsaksad Pärnus Nikolai t. 32. Sisekujunduse autorid Anna Huimerind ja Ruth Huimerind. Arhitekt Jaak Huimerind

Tampere Teatrisuve maiuspalaks olid soomlased / Tiiu Laks

Index Scriptorium Estoniae

Laks, Tiiu, 1984-

2006-01-01

38. Tampere teatrisuvest (Tamperen teatterikesä), vaatluse all on soomlaste menutükid - Anna Krogeruse "Armastusest minu vastu" (lav. Irene Aho, Soome Rahvusteater) ja William Shakespeare'i "Richard III" (lav. Juha Luukkonen, Vaasa Linnateater)

Must maja, valge aed / Mihkel Karu

Index Scriptorium Estoniae

Karu, Mihkel, 1983-

2012-01-01

Laagris 2010. aastal valminud eramust. Tänavapoolne aed on valatud betoonist. Arhitektid: Peeter Pere, Urmas Muru, Anna-Maria Erik (AB Muru & Pere). Sisearhitektid: Katrin Kaevats, Peeter Pere, Urmas Muru. Projekt. 2008. Peeter Pere kommentaar

VAMCIS, a new measuring channel for continuous monitoring of leak rates inside PWR steam generators

International Nuclear Information System (INIS)

Champion, G.; Dubail, A.; Lefevre, F.

1988-01-01

In order to assess the primary to secondary leakage, radioactive isotopes, formed in the primary coolant as a result of fission or neutron capture, are usually monitored in the pressurized water reactor (PWR) secondary coolant. Conventional methods mainly based on the detection of 133 Xe, tritium, and 41 Ar are widely used on French Electricite de France (EdF) PWRs. Some years ago, it appeared necessary to improve both leak rate assessments and steam generator tube rupture (SGTR) detection. A volumetric activity measuring channel inside steam (VAMCIS) has been developed for this purpose. The SGTR that occurred at the North Anna PWR has focused the attention of safety authorities on this new measuring channel. It is planned to implement VAMCIS at North Anna in order to check the leak rate variations more accurately

Jekaterina Vassiljeva sõgrajet v Jõhvi

Index Scriptorium Estoniae

2008-01-01

7. sept. etendatakse Jõhvi Kontserdimajas Fjodor Dostojevski abikaasa Anna Snitkina mälestuste järgi lavastatud näidendit "Ma olin õnnelik!". Peaosa mängib vene teatri- ja filminäitleja Jekaterina Vassiljeva

Thomas Mofolo: the man, the writer and his contexts

African Journals Online (AJOL)

higher studies through the Protestant PEMS Mission, Thomas grabbed this ... main centres of power in the greater Caledon River valley after 1828, and many ..... Other Christians, such as Anna 'Mantsopa Makhetha, continued faithfully to carry.

Full-length sequencing and identification of novel polymorphisms in ...

Indian Academy of Sciences (India)

Rosalia Di Gerlando

2017-08-16

Aug 16, 2017 ... ANNA MARIA SUTERA, MARIA TERESA SARDINA. ∗ ... SNPs that might be important in future studies and laid the basis for further association analyses needed to ..... Haplotype-based analysis can provide higher power,.

RESEARCH ARTICLE Full length sequencing and novel ...

Indian Academy of Sciences (India)

Navya

2016-12-16

Dec 16, 2016 ... TOLONE, ANNA MARIA SUTERA, MARIA TERESA SARDINA, BALDASSARE ... finding of novel SNPs that might be important in future studies and laid the .... power, precision and quality to assess the relationship between ...

Study of anti-inflammatory, anti-diabetic, and analgesic activity of ...

African Journals Online (AJOL)

Admin

2012-04-17

Apr 17, 2012 ... Natural products have been isolated from wide variety of taxa and tested ... Studies on marine cyanobacterial species ... compound present in the extract of O. annae. MATERIALS AND METHODS. Algae and culture conditions.

Choosing a Transplant Center

Science.gov (United States)

... however you can Daughter's dying wish became mother's motivation Be The Match Blog Stories Anna, transplant recipient ... for transplant costs. Location – You might have to travel to receive a transplant. Consider how far the ...

Tantsupäev toob publiku ette säravaid balletitähti / Raimu Hanson

Index Scriptorium Estoniae

Hanson, Raimu, 1957-

2006-01-01

29. apr. esinevad Vanemuises rahvusvaheliselt tuntud tantsijad - Tamara Rojo, Jan-Erik Wikström, Inaki Urlezaga, Anna Valev, Olga Volobujeva, Priit Kripson, Diana Cuni ja Kristoffer Sakurai -, et tähistada rahvusvahelist tantsupäeva

The relationship between tissue transglutaminase IgA antibodies ...

African Journals Online (AJOL)

Ehab

2013-07-24

Jul 24, 2013 ... The mechanism of association between the two diseases involves a shared genetic ... with systemic immune modifying biological agents. e.g. infliximab in ..... Anna SP. Coexistence of coeliac disease and type 1 diabetes.

PSOM2—partitioning-based scalable ontology matching using ...

Indian Academy of Sciences (India)

B Sathiya

2017-11-16

Nov 16, 2017 ... 1 Department of Computer Science and Engineering, College of Engineering, Guindy, Anna ... achieved by the ontology that is the new form of knowledge ... space, since only the matchable cluster pairs are considered.

Somatic mutations in breast and serous ovarian cancer young patients: a systematic review and meta-analysis

Directory of Open Access Journals (Sweden)

Giselly Encinas

2015-10-01

Full Text Available Summary Objective: our aim was to evaluate whether somatic mutations in five genes were associated with an early age at presentation of breast cancer (BC or serous ovarian cancer (SOC. Methods: COSMIC database was searched for the five most frequent somatic mutations in BC and SOC. A systematic review of PubMed was performed. Young age for BC and SOC patients was set at ≤35 and ≤40 years, respectively. Age groups were also classified in <30years and every 10 years thereafter. Results: twenty six (1,980 patients, 111 younger and 16 studies (598, 41 younger, were analyzed for BC and SOC, respectively. In BC, PIK3CA wild type tumor was associated with early onset, not confirmed in binary regression with estrogen receptor (ER status. In HER2-negative tumors, there was increased frequency of PIK3CA somatic mutation in older age groups; in ER-positive tumors, there was a trend towards an increased frequency of PIK3CA somatic mutation in older age groups. TP53 somatic mutation was described in 20% of tumors from both younger and older patients; PTEN, CDH1 and GATA3 somatic mutation was investigated only in 16 patients and PTEN mutation was detected in one of them. In SOC, TP53 somatic mutation was rather common, detected in more than 50% of tumors, however, more frequently in older patients. Conclusion: frequency of somatic mutations in specific genes was not associated with early-onset breast cancer. Although very common in patients with serous ovarian cancer diagnosed at all ages, TP53 mutation was more frequently detected in older women.

Preoperative chemoradiation with capecitabine, irinotecan and cetuximab in rectal cancer: significance of pre-treatment and post-resection RAS mutations.

Science.gov (United States)

Gollins, Simon; West, Nick; Sebag-Montefiore, David; Myint, Arthur Sun; Saunders, Mark; Susnerwala, Shabbir; Quirke, Phil; Essapen, Sharadah; Samuel, Leslie; Sizer, Bruce; Worlding, Jane; Southward, Katie; Hemmings, Gemma; Tinkler-Hundal, Emma; Taylor, Morag; Bottomley, Daniel; Chambers, Philip; Lawrie, Emma; Lopes, Andre; Beare, Sandy

2017-10-24

The influence of EGFR pathway mutations on cetuximab-containing rectal cancer preoperative chemoradiation (CRT) is uncertain. In a prospective phase II trial (EXCITE), patients with magnetic resonance imaging (MRI)-defined non-metastatic rectal adenocarinoma threatening/involving the surgical resection plane received pelvic radiotherapy with concurrent capecitabine, irinotecan and cetuximab. Resection was recommended 8 weeks later. The primary endpoint was histopathologically clear (R0) resection margin. Pre-planned retrospective DNA pyrosequencing (PS) and next generation sequencing (NGS) of KRAS, NRAS, PIK3CA and BRAF was performed on the pre-treatment biopsy and resected specimen. Eighty-two patients were recruited and 76 underwent surgery, with R0 resection in 67 (82%, 90%CI: 73-88%) (four patients with clinical complete response declined surgery). Twenty-four patients (30%) had an excellent clinical or pathological response (ECPR). Using NGS 24 (46%) of 52 matched biopsies/resections were discrepant: ten patients (19%) gained 13 new resection mutations compared to biopsy (12 KRAS, one PIK3CA) and 18 (35%) lost 22 mutations (15 KRAS, 7 PIK3CA). Tumours only ever testing RAS wild-type had significantly greater ECPR than tumours with either biopsy or resection RAS mutations (14/29 [48%] vs 10/51 [20%], P=0.008), with a trend towards increased overall survival (HR 0.23, 95% CI 0.05-1.03, P=0.055). This regimen was feasible and the primary study endpoint was met. For the first time using pre-operative rectal CRT, emergence of clinically important new resection mutations is described, likely reflecting intratumoural heterogeneity manifesting either as treatment-driven selective clonal expansion or a geographical biopsy sampling miss.

Dynamic changes to survivin subcellular localization are initiated by DNA damage

Directory of Open Access Journals (Sweden)

Maritess Gay Asumen

2010-07-01

Full Text Available Maritess Gay Asumen1, Tochukwu V Ifeacho2, Luke Cockerham3, Christina Pfandl4, Nathan R Wall31Touro University’s College of Osteopathic Medicine, Vallejo, CA, USA; 2University of Southern California, Los Angeles, CA, USA; 3Center for Health Disparities Research and Molecular Medicine, Loma Linda University, CA, USA; 4Green Mountain Antibodies, Burlington, VT, USAAbstract: Subcellular distribution of the apoptosis inhibitor survivin and its ability to relocalize as a result of cell cycle phase or therapeutic insult has led to the hypothesis that these subcellular pools may coincide with different survivin functions. The PIK kinases (ATM, ATR and DNA-PK phosphorylate a variety of effector substrates that propagate DNA damage signals, resulting in various biological outputs. Here we demonstrate that subcellular repartitioning of survivin in MCF-7 cells as a result of UV light-mediated DNA damage is dependent upon DNA damage-sensing proteins as treatment with the pan PIK kinase inhibitor wortmannin repartitioned survivin in the mitochondria and diminished it from the cytosol and nucleus. Mitochondrial redistribution of survivin, such as was recorded after wortmannin treatment, occurred in cells lacking any one of the three DNA damage sensing protein kinases: DNA-PK, ATM or ATR. However, failed survivin redistribution from the mitochondria in response to low-dose UV occurred only in the cells lacking ATM, implying that ATM may be the primary kinase involved in this process. Taken together, this data implicates survivian’s subcellular distribution is a dynamic physiological process that appears responsive to UV light- initiated DNA damage and that its distribution may be responsible for its multifunctionality.Keywords: survivin, PIK kinases, ATM, ATR, DNA-PK

Synergistic effects of targeted PI3K signaling inhibition and chemotherapy in liposarcoma.

Directory of Open Access Journals (Sweden)

Shang Guo

Full Text Available While liposarcoma is the second most common soft tissue malignant tumor, the molecular pathogenesis in this malignancy is poorly understood. Our goal was therefore to expand the understanding of molecular mechanisms that drive liposarcoma and identify therapeutically-susceptible genetic alterations. We studied a cohort of high-grade liposarcomas and benign lipomas across multiple disease sites, as well as two liposarcoma cell lines, using multiplexed mutational analysis. Nucleic acids extracted from diagnostic patient tissue were simultaneously interrogated for 150 common mutations across 15 essential cancer genes using a clinically-validated platform for cancer genotyping. Western blot analysis was implemented to detect activation of downstream pathways. Liposarcoma cell lines were used to determine the effects of PI3K targeted drug treatment with or without chemotherapy. We identified mutations in the PIK3CA gene in 4 of 18 human liposarcoma patients (22%. No PIK3CA mutations were identified in benign lipomas. Western blot analysis confirmed downstream activation of AKT in both PIK3CA mutant and non-mutant liposarcoma samples. PI-103, a dual PI3K/mTOR inhibitor, effectively inhibited the activation of the PI3K/AKT in liposarcoma cell lines and induced apoptosis. Importantly, combination with PI-103 treatment strongly synergized the growth-inhibitory effects of the chemotherapy drugs doxorubicin and cisplatin in liposarcoma cells. Taken together, these findings suggest that activation of the PI3K/AKT pathway is an important cancer mechanism in liposarcoma. Targeting the PI3K/AKT/pathway with small molecule inhibitors in combination with chemotherapy could be exploited as a novel strategy in the treatment of liposarcoma.

The Messiness of Meaning Making: Examining the Affordances of ...

African Journals Online (AJOL)

Our study is located in the field of New Literacy Studies and examines the .... tensions between power, context and identity within digital spaces. ..... Activity: In Makubalo's article, we are introduced to four learners: Thabo, Teboho, Anna.

Safe delivery, Service utilization, Metekel Zone

African Journals Online (AJOL)

decision making power of subjects were found to have a statistically significant association with preference of safe delivery ... Studies that focused on maternal mortality and proportion of ...... Anna M, Hannekee M, Frank Odhiambo et.al. Use.

"BLACK GOLD" GRADE12-LEARNERS: RELATIONSHIP BETWEEN ...

African Journals Online (AJOL)

SK

South African Journal for Research in Sport, Physical Education and Recreation, 2016, ..... It is suggested that key role-players in this rural township should make contact with the Anna ... "Statistical power analysis for the behavioural sciences".

MPs vote to investigate PM Brazauskas' family business / Milda Seputyte

Index Scriptorium Estoniae

Seputyte, Milda

2005-01-01

Leedu parlament hääletas uurimiskomisjoni loomise poolt, mis hakkab uurima peaminister Algirdas Brazauskase perekonna äritegevust. Peaminister on varem teatanud, et ei anna tunnistusi, kui selline komisjon luuakse ning võib isegi tagasi astuda

Mõned olulised raamatud / Doris Kareva

Index Scriptorium Estoniae

Kareva, Doris, 1958-

2008-01-01

Doris Kareva toob esile endale olulisi teoseid: "Greeka muinaskangelasi Anna Haava järgi", Jan Brzechwa "Lõbusaid värsse", Hector Malot' "Perekonnata", Antoine Saint-Exupéry "Väike prints", Rabindranath Tagore "Gitandzhali" ja "Aednik"

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

piperazino- and 5-morpholinoacetyl-2,2,4-trimethyl-1, 5-benzodiazepines ... Department of Physics, Anna Adarsh College for Women, Chennai 600 040, Tamil Nadu, India; P G & Research Department of Physics, Queen Mary's College, Chennai ...

Raamist välja linnaruum. Fotokonkurss 2015 / Kristel Schwede

Index Scriptorium Estoniae

Schwede, Kristel, 1963-

2015-01-01

Tallinna noortenädala fotokonkursist "Raamist välja linnaruum 2015". I koht: Samuel Markovich "Rahu". II koht: Anna Kuriljonok "A short history". III koht: Maarika Roosi "Eri lugu - eri raames". Positiivi eriauhind: Vladislava Snurnikova "Trepp"

Schiphol - üks saar muudab Hollandi / Rem Koolhaas ; tõlk. Inga Raukas

Index Scriptorium Estoniae

Koolhaas, Rem, 1944-

2000-01-01

Schipholi lennuvälja ümberpaigutamine kunstlikule saarele meres. Hollandi arhitektuuribüroo OMA arhitektuurse projekti kirjeldus. Projekteerijad Rem Koolhaas, Reinier de Graaf, Jens Hommert, Mateo Poli, Adam Kurdahl, Anna Little, Bert Karel Deuten. 23 ill

Tartu Ülikooli kümme geeniust / Alo Lõhmus

Index Scriptorium Estoniae

Lõhmus, Alo

2007-01-01

Valik Tartu Ülikoolis 375 aasta jooksul kõige rohkem maailmateadust mõjutanud teadlasi: Friedrich Georg Wilhelm Stuve, Martin Heinrich Rathke, Karl Ernst von Baer, Karl Wilhelm von Kupffer, Juri Lotman, Ludvig Puusepp Nikolai Pirogov, Ernst Öpik, Ivan Kondakov, Karl Bücher, Karl Friedrich Burdach ja Gustav Teichmüller

7 CFR 1435.504 - Timing of distribution of CCC-owned sugar.

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Timing of distribution of CCC-owned sugar. 1435.504... CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS SUGAR PROGRAM Processor Sugar Payment-In-Kind (PIK) Program § 1435.504 Timing of distribution of CCC-owned sugar. Distribution of sugar...

ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration

Czech Academy of Sciences Publication Activity Database

Jaiswal, H.; Benada, Jan; Müllers, E.; Akopyan, K.; Burdová, Kamila; Koolmeister, T.; Helleday, T.; Medema, R.H.; Macůrek, Libor; Lindqvist, A.

2017-01-01

Roč. 36, č. 14 (2017), s. 2161-2176 ISSN 0261-4189 R&D Projects: GA ČR GA13-18392S Institutional support: RVO:68378050 Keywords : ATM * ATR * checkpoint recovery * G2 * Pik1 Subject RIV: EB - Genetics ; Molecular Biology OBOR OECD: Cell biology Impact factor: 9.792, year: 2016

Molecular Markers Increase Precision of the European Association of Urology Non-Muscle-Invasive Bladder Cancer Progression Risk Groups

DEFF Research Database (Denmark)

van Kessel, Kim E M; van der Keur, Kirstin A; Dyrskjøt, Lars

2018-01-01

prospectively included 1,239 patients in follow-up for NMIBC in six European countries. Fresh-frozen tumor samples were analyzed for GATA2, TBX2, TBX3, and ZIC4 methylation and FGFR3, TERT, PIK3CA, and RAS mutation status. Cox regression analyses identified markers that were significantly associated...

Arstidel on keeruline võõrsilt naasta / Hanneli Rudi

Index Scriptorium Estoniae

Rudi, Hanneli

2011-01-01

Aastaid välismaal töötanud arstidel on raske Eestis tööd leida, sest vastavaid töökuulutusi Eesti Arstide Liidu ja haiglate kodulehed ei avalda. Eestisse tagasi tulla sooviv neuroloog Merle Ööpik ja lastepsühholoog Airiin Demir oma tööotsimiskogemustest

Врачам сложно возвращаться в родную страну / Ханнели Руди

Index Scriptorium Estoniae

Руди, Ханнели

2011-01-01

Aastaid välismaal töötanud arstidel on raske Eestis tööd leida, sest vastavaid töökuulutusi Eesti Arstide Liidu ja haiglate kodulehed ei avalda. Eestisse tagasi tulla sooviv neuroloog Merle Ööpik ja lastepsühholoog Airiin Demir oma tööotsimiskogemustest

Research Article

African Journals Online (AJOL)

2016-05-15

May 15, 2016 ... We are listed under Research Associations category. .... important squares, Hidalgo Square in Mexico City, Plaza Santa Anna in Spain and Antarvasna ... source material efficiency; understand the power of God and a spirit of ...

Size-independent peak shift between normal and upconversion ...

Indian Academy of Sciences (India)

2014-02-12

Feb 12, 2014 ... 1Crystal Growth Centre, Anna University, Chennai 600 025, India. 2Laser Physics ... the power-dependent upconversion photoluminescence (UCPL), it has been shown that the origin of UCPL ... For the past few years, studies.

TURKISH AND BRICS ENGAGEMENT IN AFRICA

African Journals Online (AJOL)

RAYAN_

This article studies the political economy of Turkey's relations with sub-Saharan .... 5 Abdirahman Ali, “Turkey's Foray into Africa: A New Humanitarian Power? ..... 25 Anna Brezhneva and Daria Ukhova, Russia as a Humanitarian Aid Donor ( ...

Optimal capacitor placement and sizing using combined fuzzy ...

African Journals Online (AJOL)

user

The studies have specified that as much as 13% of total power generated is consumed as ... sizing is designed with the objective function, which minimises the power loss. ..... System Engineering in 2007 (Anna University) Tamil Nadu, India.

Galeotti on recognition as inclusion

DEFF Research Database (Denmark)

Lægaard, Sune

2008-01-01

Anna Elisabetta Galeotti's theory of 'toleration as recognition' has been criticised by Peter Jones for being conceptually incoherent, since liberal toleration presupposes a negative attitude to differences, whereas multicultural recognition requires positive affirmation hereof. The paper spells ...

A. H. T. lahkumine Koitjärvelt : lapse sünd "Kõrboja peremehes" / Toomas Haug

Index Scriptorium Estoniae

Haug, Toomas, 1956-

2007-01-01

Anton Hansen Tammsaare romaanist "Kõrboja peremees", selle kokkupuudetest Knut Hamsuni loominguga ning romaani religioossetest aspektidest, samuti Kõrboja Anna tegelaskujust. Sisaldab värsse Soome eeposest "Kalevala". Räägitakse ka Anton Hansen Tammsaare suhetest Käthe Hanseniga

Plaadid / Tiia Teder

Index Scriptorium Estoniae

Teder, Tiia, 1959-

2002-01-01

Uutest plaatidest Klaus König "Black Moments", Weekend Players "Pursuit Of Happiness", Da Buzz "Wanna Be With Me?", Covenant "Northern Light", Tracy Chapman "Lett It Rain", Jeff "Tain" Watts "Bar Talk", Marco "Anna aega", Cassius "Aau Reve"

Suitsunurgas sosistatakse siis, kui avalikult öelda ei saa / Anneli Salk

Index Scriptorium Estoniae

Salk, Anneli

2006-01-01

Kuulujutte saab vältida, andes töötajale ettevõttes toimuvast laiemat infot kui ainult tema kitsast töölõiku puudutav. Kommenteerib Anna Tammerik. Vt. samas: Suhete kujunemisel saab esile tuua nelja etappi

Prognostic and predictive value of p-Akt, EGFR, and p-mTOR in early breast cancer

Energy Technology Data Exchange (ETDEWEB)

Lazaridis, Georgios; Lambaki, Sofia [Hospital, Department of Pathology, Thessaloniki (Greece); Karayannopoulou, Georgia [Aristotle Univ. of Thessaloniki School of Medicine, Thessaloniki (Greece). Dept. of Pathology; Eleftheraki, Anastasia G. [Data Office, Athens (Greece). Section of Biostatistics; Papaspirou, Irene [Alexandra Hospital, Athens (Greece). Dept. of Pathology; Bobos, Mattheos [Aristotle Univ. of Thessaloniki School of Medicine, Thessaloniki (Greece). Lab. of Molecular Oncology; Efstratiou, Ioannis [Papageorgiou Hospital, Thessaloniki (Greece). Dept. of Pathology; Pentheroudakis, George [Ioannina Univ. Hospital, Ioannina (Greece). Dept. of Medical Oncology; Zamboglou, Nikolaos [Klinikum Offenbach (Germany). Dept. of Radiation Oncology; Fountzilas, George [Hospital, Department of Pathology, Thessaloniki (Greece); Aristotle Univ. of Thessaloniki School of Medicine, Thessaloniki (Greece). Lab. of Molecular Oncology

2014-07-15

There are scarce data available on the prognostic/predictive value of p-Akt and p-mTOR protein expression in patients with high-risk early breast cancer. Formalin-fixed paraffin-embedded (FFPE) tumor tissue samples from 997 patients participating in two adjuvant phase III trials were assessed for EGFR, PTEN, p-Akt, p-mTOR protein expression, and PIK3CA mutational status. These markers were evaluated for associations with each other and with selected patient and tumor characteristics, immunohistochemical subtypes, disease-free survival (DFS), and overall survival (OS). p-mTOR protein expression was negatively associated with EGFR and positively associated with PTEN, with p-Akt473, and with the presence of PIK3CA mutations. EGFR expression was positively associated with p-Akt473, p-Akt308, and PIK3CA wild-type tumors. Finally, p-Akt308 was positively associated with p-Akt473 expression. In univariate analysis, EGFR (p = 0.016) and the coexpression of EGFR and p-mTOR (p = 0.015) were associated with poor OS. Among patients with p-Akt308-negative or low-expressing tumors, those treated with hormonal therapy were associated with decreased risk for both relapse and death (p = 0.013 and p < 0.001, respectively). In the subgroup of patients with locoregional relapse, positive EGFR and mTOR protein expression was found to be associated with increased (p = 0.034) and decreased (p < 0.001) risk for earlier relapse, respectively. In multivariate analysis, low levels of p-Akt308 and the coexpression of EGFR and p-mTOR retained their prognostic value. Low protein expression of p-Akt308 was associated with improved DFS and OS among patients treated with hormonal therapy following adjuvant chemotherapy. Coexpression of EGFR and p-mTOR was associated with worse OS. (orig.) [German] Geringe Daten existieren ueber den prognostischen/praediktiven Wert der p-Akt- und p-mTOR-Proteinexpression bei Patienten mit ''High-risk''-Mammakarzinom im Fruehstadium

Morphological outcomes of gynandromorphism in Lycaeides butterflies (Lepidoptera: Lycaenidae).

Science.gov (United States)

Jahner, Joshua P; Lucas, Lauren K; Wilson, Joseph S; Forister, Matthew L

2015-01-01

The genitalia of male insects have been widely used in taxonomic identification and systematics and are potentially involved in maintaining reproductive isolation between species. Although sexual selection has been invoked to explain patterns of morphological variation in genitalia among populations and species, developmental plasticity in genitalia likely contributes to observed variation but has been rarely examined, particularly in wild populations. Bilateral gynandromorphs are individuals that are genetically male on one side of the midline and genetically female on the other, while mosaic gynandromorphs have only a portion of their body developing as the opposite sex. Gynandromorphs might offer unique insights into developmental plasticity because individuals experience abnormal cellular interactions at the genitalic midline. In this study, we compare the genitalia and wing patterns of gynandromorphic Anna and Melissa blue butterflies, Lycaeides anna (Edwards) (formerly L. idas anna) and L. melissa (Edwards) (Lepidoptera: Lycaenidae), to the morphology of normal individuals from the same populations. Gynandromorph wing markings all fell within the range of variation of normal butterflies; however, a number of genitalic measurements were outliers when compared with normal individuals. From these results, we conclude that the gynandromorphs' genitalia, but not wing patterns, can be abnormal when compared with normal individuals and that the gynandromorphic genitalia do not deviate developmentally in a consistent pattern across individuals. Finally, genetic mechanisms are considered for the development of gynandromorphism in Lycaeides butterflies. © The Author 2015. Published by Oxford University Press on behalf of the Entomological Society of America.

TRADIÇÃO E INOVAÇÃO NA ERA DIGITAL: VALOR SIMBÓLICO, CULTURA E MARKETING

Directory of Open Access Journals (Sweden)

Cecília Oliveira Bezerra

Full Text Available RESUMO O objetivo deste caso de ensino é gerar aprendizagem sobre a criação de valor simbólico e cultural de bens de consumo no contexto da comunicação virtual. Dessa forma, o caso também permite aprender sobre a importância desse tipo de valor dentro das práticas de marketing digital. A história gravita em torno da gestora Anna, que enfrenta uma crise na empresa que administra com sua mãe, diretora e fundadora. A Tear é uma empresa no segmento de moda, que confecciona objetos caracterizados pelo design sofisticado, trabalho artesanal refinado e peças únicas. Ao atender uma consumidora que pretende adquirir um vestido de noiva, Anna escuta um relato sobre a Tiffany’s & Co. e vislumbra, então, uma alternativa potencial para enfrentar a crise. Depois de conversar com a diretora, decide investir em uma visita na sede da Tiffany’s & Co. em Nova Iorque, nos Estudos Unidos. Ela conversa com várias pessoas e adquire várias experiências. Com tudo isso, Anna descobre como o marketing digital e o comércio eletrônico podem transformar produtos artesanais em objetos de desejo, conciliando inovação com tradição. Todavia, descobre também o inverso: como a dimensão cultural e simbólica pode qualificar as práticas de marketing digital.

Detection and prevalence of Haemoproteus archilochus (Haemosporida, Haemoproteidae) in two species of California hummingbirds.

Science.gov (United States)

Bradshaw, A C; Tell, L A; Ernest, H B; Bahan, S; Carlson, J; Sehgal, R N M

2017-07-01

Haemosporidian blood parasites are transmitted to a wide range of avian hosts via blood-sucking dipteran vectors. Microscopy has revealed an impressive diversity of avian haemosporidia with more than 250 species described. Moreover, PCR and subsequent sequence analyses have suggested a much greater diversity of haemosporidia than morphological analyses alone. Given the importance of these parasites, very few studies have focused on the charismatic hummingbirds. To date, three Haemoproteus species (Haemoproteus archilochus, Haemoproteus trochili, and Haemoproteus witti) and one Leucocytozoon species (Leucocytozoon quynzae) have been described in blood samples taken from hummingbirds (Trochilidae). Unconfirmed Plasmodium lineages have also been detected in hummingbirds. Here, we report the detection of H. archilochus in two hummingbird species (Calypte anna and Archilochus alexandri) sampled in Northern California and perform a phylogenetic analysis of mitochondrial cytochrome b (cyt b) gene lineages. A total of 261 hummingbirds (157 C. anna, 104 A. alexandri) were sampled and screened for blood parasites using PCR and microscopy techniques. Combining both methods, 4 (2.55%) haemosporidian infections were detected in C. anna and 18 (17.31%) haemosporidian infections were detected in A. alexandri. Molecular analyses revealed four distinct H. archilocus cyt b lineages, which clustered as a monophyletic clade. No species of Plasmodium or Leucocytozoon were detected in this study, raising the possibility of specific vector associations with hummingbirds. These results provide resources for future studies of haemosporidian prevalence, diversity, and pathogenicity in California hummingbird populations.

Anneli Remme soovitab : Prima la donna / Anneli Remme

Index Scriptorium Estoniae

Remme, Anneli, 1968-

2002-01-01

Rahvusooperis Estonia etenduvad 25. mail Straussi ooper "Salome", 23. mail ballett "Cassandra", 24. mail de Falla hispaania-eksootiline ooper "Lühike elu", 25. mail Carl Orffi "Tark naine", 26. mail Shtshedrini ballett "Anna Karenina" ja Bizet' ooper "Carmen"

Pala kooli direktor Malle Weinrauch muretseb maakoolide tuleviku pärast / Eva Klaas

Index Scriptorium Estoniae

Klaas, Eva

2003-01-01

Konkursi "Eestimaa kauneim kool" tiitli võitnud Anna Haava nimelisest Pala koolist. Kooli direktor Malle Weinrauch'i sõnul oli president Arnold Rüütli külaskäik suursündmus nii kooli õpetajatele kui õpilastele

Influence of intermolecular interactions on the properties of carbon ...

Indian Academy of Sciences (India)

46

Piotr Kamedulski , Anna Kaczmarek-Kedziera, Jerzy P. Lukaszewicz .... recent studies on this class of compounds/materials were predominantly .... Power 150 mW), Leica DM1300M camera Infinity 1; objective: Leica, N PLAN L50x/0.5).

Book Reviews/ Notes de lecture

African Journals Online (AJOL)

sulaiman.adebowale

2006-08-29

Aug 29, 2006 ... 189–194. © Council for the Development of Social Science Research in Africa, 2006 ... Globalization, for instance, has undermined the legitimacy and power .... The third chapter by Anna Madoeff examines the role of Moulids.

LALIGENS

African Journals Online (AJOL)

ESSOH GRACE

2015-05-10

May 10, 2015 ... to the discourse and studies in African literature. Contemporary Female Writing ... a social class achieves a predominant influence and power, not by direct and overt means, but by ..... Petersen, Anna Rutherford. A Shaping of ...

Minimization of sink mark defects in injection molding process ...

African Journals Online (AJOL)

user

3Institute of Remote Sensing, Anna University, Chennai-600025, INDIA .... Most of the Taguchi based studies used sink mark index or sink index as the parameter. It is an .... Maintaining higher pack pressure requires additional power and cost.

The Nation and the Subaltern in Yvonne Vera's Butterfly Burning

African Journals Online (AJOL)

place of African women in the context of power both within the colonial and the postcolonial moments. This image of ..... sense of women's rebelliousness appears in studies from Zimbabwe,” she writes, “which ..... Eds. Anna Rutherford, Lars.

Black parental involvement in education

African Journals Online (AJOL)

Erna Kinsey

The South African Schools Act of 1996 (SASA) provides formal power in education to parents as well as communities. ... Review of selected studies on parental involvement in ..... Anna, a Grade 11 teacher, summed up the feelings of the.

Revisiting trauma and homo religiosus in selected texts by Mongo ...

African Journals Online (AJOL)

2018-03-19

Mar 19, 2018 ... a century of research in the area of trauma and millennia of scholarship on religion. Religion ... growing socio-political dissatisfaction with absolute power which in its highest form was God .... Anna-Marie de Beer summarises.

USA folkloristid tutvustavad Eestis afroameerika rahvamuusikat / Andres Roost

Index Scriptorium Estoniae

Roost, Andres

2008-01-01

9. veebruaril tutvustavad USA folkloristid Anna Lomax Wood ja Todd Dunham Harvey Eesti Kirjandusmuuseumi saalis Tartus John A. Lomaxi (1867-1948) ja Alan Lomaxi (1915-2002) kogutud afroameerika folkloori, näidatakse dokumentaalfilmi "Land Where the Blues Began"

2015. aasta parimad sisustusblogid / Kaili Kannel

Index Scriptorium Estoniae

Kannel, Kaili

2015-01-01

Amara interjööriblogide konkursil selgunud parimad blogid: Copperline, The Lovely Drawer, English Buildings, Lucy Loves Ya, Mad About The House, Lucy Gough Stylist Blog, Don't Cramp my Style, Flat 15, Anna E. Lee Interior Design

Prantsuse näitlejanna tahab publikut muuta

Index Scriptorium Estoniae

2009-01-01

Prantsuse näitleja Mireille Perrier mängib 18. oktoobril Ugalas Stefano Massini näidendi "Donna non rieducabile" alusel lavastatud monodraamat "Parandamatu". Näidend kajastab vene ajakirjaniku Anna Politkovskaja mõtteid Tšetšeenias kogetust

Aflatoxin: An Old Carcinogen Teaches Us New Tricks | Division of Cancer Prevention

Science.gov (United States)

Speaker John D. Groopman, PhD Anna M. Baetjer Professor of Environmental Health Sciences Johns Hopkins Bloomberg School of Public Health Associate Director for Population Sciences Sidney Kimmel Comprehensive Cancer Center Johns Hopkins School of Medicine Baltimore, MD |

Uus eksamikord tõi 13 tudengi eksmati / Inga Uusmaa

Index Scriptorium Estoniae

Uusmaa, Inga

2001-01-01

Eesti Sisekaitseakadeemias kehtestatud vaheeksami süsteemist, mille järgi tuleb igas aines sooritada kaks eksamit, teine eksam ei anna küll ainepunkte, kuid selles läbikukkumine tähendab seniste ainetulemuste tühistamist

Bulletin of Materials Science | News

Indian Academy of Sciences (India)

... India; Department of Mechanical Engineering, Anna University, Chennai 600025, India; PG and Research Department of Physics, Thiru Kolanjiappar Governement Arts College, Vridhachalam 606001, India; Department of Civil Engineering, Thiruvalluvar College of Engineering and Technology, Vandavasi 604505, India ...

Responses of selected biota after biostimulation of a vegetable oil ...

African Journals Online (AJOL)

Responses of selected biota after biostimulation of a vegetable oil spill in the Con Joubert Bird Sanctuary wetland: A pilot study. Mapurunyane C Selala, Paul J Oberholster, Karen AK Surridge, Arno R de Klerk, Anna-Maria Botha ...

Vaikus moefotograafias / Kristina Paju

Index Scriptorium Estoniae

Paju, Kristina

2007-01-01

EKA moemagistrandi Kristina Paju ja fotograafide Anna-Stina Treumundi ning Kaisa Eiche näitusest "Vaikus moefotograafias", mille eesmärgiks on kirjeldada võimalusi, millised võiksid olla vaikuse eri aspektid, ka moefotograafias, toetudes Jean Baudrillardi teooriale

The thread of depression throughout the life and works of Leo Tolstoy.

Science.gov (United States)

Anargyros-Klinger, Annie

2002-04-01

Tolstoy, the author of two masterpieces, War and Peace and Anna Karenina, remains a writer of genius. Yet, after writing War and Peace, his existence had been torn apart by a serious depression. This depression, which was melancholic in character, almost destroyed him and, once he had finished Anna Karenina, led him to want to renounce not only sexuality but also literary creation and material possessions. Through examining Tolstoy's life and work, the author tries to uncover the underground paths of this depression, which emerged brutally in the middle of his life, and to understand why his creative genius dried up. Like Leonardo da Vinci, Tolstoy turned away from his artistic work, declaring that 'art is not only useless but even harmful', and thereafter devoted himself to philosophical, political and religious writings. These new sublimations would help him to recover his health.

Barbaros Basileus. Parodie und Lob in der Darstellung der Barbarenfürsten im Roman Rhodanthe und Dosikles von Theodoros Prodromos

Directory of Open Access Journals (Sweden)

Ondřej Cikán

2017-10-01

Full Text Available The Heidelberg manuscript of the novel contains a dedication poem for a Kαῖσαρ, who was identified with Nikephoros Bryennios, the husband of Anna Komnene. At first glance, we see that the names of the characters Gobryas, Bryaxes and Brya contain strong assonances to the name of the addressee. After a closer consideration we recognize 1 that especially the two barbarians Gobryas and Bryaxes offer for Bryennios a certain potential of identification, 2 that there may be some humorous allusions on the attended coup from 1118/1119, 3 that the author tries to satisfy also his patronesses Eirene Doukaina and Anna Komnene and 4 that despite every parody of the court, the author takes care not to insult the acting Emperor, but to honour him. The considerations have influence on the dating of the novel.

Leukocyte Reference Intervals for Free-Ranging Hummingbirds in Northern California.

Science.gov (United States)

Safra, Noa; Christopher, Mary M; Ernest, Holly B; Bandivadekar, Ruta; Tell, Lisa A

2018-04-04

  Hummingbirds are specialized nectarivores and important ecological pollinators that are the focus of conservation efforts as well as scientific investigations of metabolism and flight dynamics. Despite their importance, basic information is lacking about hummingbird blood cells. We aimed to establish reference intervals for total and differential leukocyte counts from healthy free-ranging hummingbirds in northern California. Hummingbirds were captured in five counties in spring and summer of 2012. A drop of blood was used to prepare smears for total white blood cell estimate and 200-cell differential leukocyte counts. Reference Value Advisor was used for descriptive statistics and calculation of reference intervals. Blood smears from 42 Anna's Hummingbirds ( Calypte anna) and 33 Black-chinned Hummingbirds ( Archilochus alexandri) were included. The only significant differences in leukocyte counts were due to age, and juvenile hummingbirds had significantly higher lymphocyte counts than adult hummingbirds ( Phummingbirds.

Genetics Home Reference: ovarian cancer

Science.gov (United States)

... is most often associated with mutations in the MLH1 or MSH2 gene and accounts for between 10 ... AKT1 BARD1 BRCA1 BRCA2 BRIP1 CDH1 CHEK2 CTNNB1 MLH1 MRE11 MSH2 MSH6 NBN OPCML PALB2 PIK3CA PMS2 ...

Alternative splicing in colon, bladder, and prostate cancer identified by exon-array analysis

DEFF Research Database (Denmark)

Thorsen, Kasper; Sørensen, Karina D.; Brems-Eskildsen, Anne Sofie

2008-01-01

, PIK4CB, TPM1, and VCL). The validated tumor-specific splicing alterations were highly consistent, enabling clear separation of normal and cancer samples and in some cases even of different tumor stages. A subset of the tumor-specific splicing alterations (ACTN1, CALD1, and VCL) was found in all three...

V poiskah smõsla zhizni / Irina Butjajeva

Index Scriptorium Estoniae

Butjajeva, Irina

2007-01-01

Vene Teater avas uue hooaja 1. sept. David Mamet' näidendiga "Erootilised fantaasiad Chicagos" Sergei Puhljakovi (Moskva) lavastuses pealkirjaga "M ja N" ja 14. augustil esietendus Quentin Tarantino filmistsenaariumil "Marukoerad" ("Reservoir Dogs") põhinev lavastus, lavastaja Anna Trifonova

Filmil on Sõpruse kinos kohtumine - ta kohtub fotoga

Index Scriptorium Estoniae

2011-01-01

Eesti esimesest fotofilmide festivalist 14. okt.-l Tallinnas kinos Sõprus, tutvustavad kuraatorid Anna Hints ja Alis Mäesalu. Lühidalt eesti fotofilmi ajaloost, rahvusvahelisest fotofimide konkursist "Ajatu lugu". Seminaril ettekanded Liina Siibilt ja Gusztáv Hámosilt (Saksamaa)

remembering the heidelberg catechism in south africa today?

African Journals Online (AJOL)

deserves to be known and studied. ... In an essay for the recent anniversary publication Power of. Faith: 450 years of the Heidelberg Catechism, Herman Selderhuis refers to Anna Maria van Schurman, the first woman to attend lectures at the.

A critical analysis of multilingual dictionaries

African Journals Online (AJOL)

user

(ANNA) attempts to make a case for the value of reading a dictionary for recreation ... This assumption, however, should be supported by actual user studies and ...... inexperienced user can incorrectly conclude that ka is the word for power in.

EU-UN partnership in military conflict management: Whither the ...

African Journals Online (AJOL)

light of this argument, many studies have analysed this relationship in terms of ... the result of great power rivalry, but, in part, also the consequence of differing .... Minister, Anna Lindh, and the UN Secretary-General, Kofi Annan, endorsed the.

276----14 Dec 2009 [Final version].indd

African Journals Online (AJOL)

2009-12-14

Dec 14, 2009 ... study of authors themselves (the literate few) and in studies of analogy and ..... power. The expectation of future vindication, even taking part in divine judgment ...... Anna Rebecca Solevåg (PhD candidate, Oslo. University ...

Muusika

Index Scriptorium Estoniae

2005-01-01

Anna-Liisa Bezrodny III preemia võidust rahvusvahelisel viiuldajate konkursil, 8. märtsil algavast Viljandi Kultuuriakadeemia suurüritusest muusikatriaad 2005, Erkki-Sven Tüüri "Passion" ettekandest Sydneys, Eesti Richard Wagneri Ühingu korraldatavast kontserdist Estonia talveaias

Journal of Genetics | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Genetics; Volume 96; Issue 1. Transcript variations, phylogenetic tree and chromosomal localization of porcine aryl hydrocarbon receptor (AhR) and AhR nuclear translocator (ARNT) genes. AGNIESZKA SADOWSKA LUKASZ PAUKSZTO ANNA NYNCA IZABELA SZCZERBAL KARINA ...

Meie esimesed naisfotograafid / Annika Haas

Index Scriptorium Estoniae

Haas, Annika, 1974-

2015-01-01

Eesti naisfotograafid Hilja Riet ja Lydia Tarem. Fotomuuseumi aastanäitus "Varjust välja. Esimesed naisfotograafid Eestis", kus tutvustatakse Hilja Rieti, Lydia Taremi, Anna Kuke ja Evi Lembergi loomingut. Näituse kuraatorid Betty Ester-Väljaots, Merili Reinpalu

Nash tshelovek v Milane / Ksenia Repson

Index Scriptorium Estoniae

Repson, Ksenia

2006-01-01

Eesti Kunstiakadeemia tööstusdisaini eriala III kursuse tudeng Pavel Sidorenko sai I koha ja kursusekaaslane Anna-Maria Einla II koha noorte disainerite konkursil Massimo Martini Design Award Milanos. Konkursi korraldusest, Sidorenko ja Einla konkursitöödest

Insights into Nod factor signaling mediated by Medicago truncatula LysM receptor-like kinases, MtNFP and MtLYK3

NARCIS (Netherlands)

Pietraszewska-Bogiel, A.

2012-01-01

Anna Pietraszewska-Bogiel wilde weten waarom rhizobia-bacteriën ervoor zorgen dat vlinderbloemige plantensoorten, waartoe ook peulvruchtsoorten als bonen, erwten en soja behoren, op stikstofarme grond kunnen groeien. Daarvoor onderzocht ze het moleculaire mechanisme achter de interactie tussen