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Sample records for picture system iaps

  1. Adaptation of the International Affective Picture System (IAPS) for European Portuguese.

    Science.gov (United States)

    Soares, Ana Paula; Pinheiro, Ana P; Costa, Ana; Frade, Carla Sofia; Comesaña, Montserrat; Pureza, Rita

    2015-12-01

    This study presents the results of the adaptation of the International Affective Picture System (IAPS) for European Portuguese (EP). Following the original procedure of Lang et al., 2000 native speakers of EP rated the 1,182 pictures of the last version of the IAPS set on the three affective dimensions of valence, arousal, and dominance, using the Self-Assessment Manikin (SAM). Results showed that the normative values of the IAPS for EP are properly distributed in the affective space of valence and arousal, showing the typical boomerang-shaped distribution observed in previous studies. Results also point to important differences in the way Portuguese females and males react to affective pictures that should be taken into consideration when planning and conducting research with Portuguese samples. Furthermore, the results from the cross-cultural comparisons between the EP ratings and the ratings from the American, Spanish, Brazilian, Belgian, Chilean, Indian, and Bosnian-Herzegovinian standardizations, showed that in spite of the fact that IAPS stimuli elicited affective responses that are similar across countries and cultures (at least in Western cultures), there are differences in the way Portuguese individuals react to IAPS pictures that strongly recommend the use of the normative values presented in this work. They can be downloaded as a supplemental archive at http://brm.psychonomic-journals.org/content/supplemental or at http://p-pal.di.uminho.pt/about/databases.

  2. Adaptación española del "International Affective Picture System" (IAPS: tercera parte

    Directory of Open Access Journals (Sweden)

    Javier Moltó

    2013-10-01

    Full Text Available Este trabajo proporciona los valores normativos españoles de las 358 imágenes que forman los conjuntos 15 a 20 del International Affective Picture System (IAPS. En este estudio participaron 811 estudiantes universitarios (521 mujeres que evaluaron las imágenes en las dimensiones emocionales de valencia, activación y dominancia. Las correlaciones entre las evaluaciones estadounidenses y las españolas en todas las dimensiones fueron altamente significativas y, como en Estados Unidos, la distribución de las imágenes en el espacio bidimensional afectivo definido por las dimensiones de valencia y activación adoptó la típica forma de boomerang. Los resultados confirmaron, asimismo, las diferencias de género encontradas en Estados Unidos en las evaluaciones de las imágenes aversivas. Estos resultados son totalmente consistentes con los obtenidos en la primera y segunda parte de la adaptación española, y demuestran que la estandarización del IAPS en nuestro país ha sido adecuada. Por último, se ratificaron las pequeñas diferencias transculturales encontradas en las evaluaciones de activación y dominancia: los españoles tendieron a asignar a las imágenes mayores puntuaciones en activación y menores en dominancia que los estadounidenses. Estos datos apoyan los estereotipos culturales de estos países y sugieren que el IAPS podría ser un indicador fiable de diferencias transculturales en la disposición emocional.

  3. Normas brasileiras para o International Affective Picture System (IAPS: comunicação breve Normas brasileñas para el International Affective Picture System (IAPS: breve comunicación Brazilian norms for the International Affective Picture System (IAPS: brief report

    Directory of Open Access Journals (Sweden)

    Rafaela Larsen Ribeiro

    2004-08-01

    Full Text Available O presente artigo apresenta valores normativos brasileiros para o International Affective Picture System (IAPS, um conjunto de estímulos com potencial de eliciar emoções amplamente utilizado na investigação experimental. Também são apresentados aqui os resultados da comparação entre as respostas de homens e mulheres brasileiros. Um total de 1062 universitários brasileiros (364 homens e 698 mulheres foram incluídos e avaliaram as 707 fotografias do IAPS nas dimensões prazer, alerta e dominância, utilizando o mesmo procedimento do estudo normativo original realizado por Lang et al. nos Estados Unidos, em 1999.Este artículo presenta valores normativos brasileños para el International Affective System (IAPS, un conjunto de estímulos con potencial de poner al descubierto emociones, que es ampliamente utilizado en la investigación experimental. Además, se presentan los resultados de la comparación entre las respuestas de hombres y mujeres brasileños. Un total de 1062 universitarios brasileños (364 hombres y 698 mujeres han sido incluidos y evaluaron las 707 diapositivas del IAPS en los niveles placer, alerta y dominancia, utilizando el mismo procedimiento del estudio normativo original realizado por Lang et al. en Estados Unidos, en 1999.The present article provides Brazilian norms for the International Affective Picture System (IAPS, a set of affectively salient photographic slides widely used in experimental research. In addition, the article compares the responses of male and female volunteers to the system in Brazil. A total of 1062 Brazilian university students (364 men and 698 women were included, and they rated 707 pictures from the IAPS in terms of valence, arousal, and dominance, following the methodology of the original normative study carried out by Lang et al. in the United States in 1999.

  4. Comparison of Brazilian and American norms for the International Affective Picture System (IAPS Comparação entre normas brasileiras e norte-americanas do International Affective Picture System (IAPS

    Directory of Open Access Journals (Sweden)

    Rafaela Larsen Ribeiro

    2005-09-01

    Full Text Available OBJECTIVE: The present article compares Brazilian and American norms for the International Affective Picture System (IAPS, a set of normative emotional photographic slides for experimental investigations. METHODS: Subjects were 1,062 Brazilian university students (364 men and 698 women who rated 707 pictures from the IAPS in terms of pleasure, arousal, and dominance following the methodology of the original normative study in the US, enabling direct comparison of data from the two samples through Pearson product moment correlation and Student t test. RESULTS: All correlations were highly significant with the highest level for the pleasure dimension, followed by dominance and arousal. However, contrary to the American normative values, our data showed that Brazilian subjects generally assigned higher arousal ratings overall. CONCLUSION: Our findings confirm that this set of stimuli can be used in Brazil as an affective rating tool due to the high correlations found across the two populations, despite differences on the arousal dimension, which are discussed in detail.OBJETIVO: O presente artigo compara as normas obtidas no Brasil e nos EUA para o "International Affective Picture System" (IAPS, um conjunto de fotografias emocionais amplamente utilizado na investigação experimental. MÉTODOS: Os sujeitos foram 1.062 universitários brasileiros (364 homens e 698 mulheres que avaliaram as 707 fotografias do IAPS nas dimensões prazer, alerta e dominância, utilizando o mesmo procedimento do estudo normativo original realizado nos EUA, permitindo uma comparação direta dos dados através de correlações lineares de Pearson e testes t de Student. RESULTADOS: Todas as correlações entre as populações foram altamente significativas, sendo o maior coeficiente o da dimensão prazer, seguido da dimensão dominância e alerta. Entretanto, os brasileiros atribuíram maiores valores médios à dimensão alerta do que os norte-americanos. CONCLUSÃO: Os

  5. Inhibitor of apoptosis (IAP)-like protein lacks a baculovirus IAP repeat (BIR) domain and attenuates cell death in plant and animal systems.

    Science.gov (United States)

    Kim, Woe Yeon; Lee, Sun Yong; Jung, Young Jun; Chae, Ho Byoung; Nawkar, Ganesh M; Shin, Mi Rim; Kim, Sun Young; Park, Jin Ho; Kang, Chang Ho; Chi, Yong Hun; Ahn, Il Pyung; Yun, Dae Jin; Lee, Kyun Oh; Kim, Young-Myeong; Kim, Min Gab; Lee, Sang Yeol

    2011-12-09

    A novel Arabidopsis thaliana inhibitor of apoptosis was identified by sequence homology to other known inhibitor of apoptosis (IAP) proteins. Arabidopsis IAP-like protein (AtILP) contained a C-terminal RING finger domain but lacked a baculovirus IAP repeat (BIR) domain, which is essential for anti-apoptotic activity in other IAP family members. The expression of AtILP in HeLa cells conferred resistance against tumor necrosis factor (TNF)-α/ActD-induced apoptosis through the inactivation of caspase activity. In contrast to the C-terminal RING domain of AtILP, which did not inhibit the activity of caspase-3, the N-terminal region, despite displaying no homology to known BIR domains, potently inhibited the activity of caspase-3 in vitro and blocked TNF-α/ActD-induced apoptosis. The anti-apoptotic activity of the AtILP N-terminal domain observed in plants was reproduced in an animal system. Transgenic Arabidopsis lines overexpressing AtILP exhibited anti-apoptotic activity when challenged with the fungal toxin fumonisin B1, an agent that induces apoptosis-like cell death in plants. In AtIPL transgenic plants, suppression of cell death was accompanied by inhibition of caspase activation and DNA fragmentation. Overexpression of AtILP also attenuated effector protein-induced cell death and increased the growth of an avirulent bacterial pathogen. The current results demonstrated the existence of a novel plant IAP-like protein that prevents caspase activation in Arabidopsis and showed that a plant anti-apoptosis gene functions similarly in plant and animal systems.

  6. The Emotional Experience of People with Intellectual Disability: An Analysis Using the International Affective Pictures System

    Science.gov (United States)

    Bermejo, Belen G.; Mateos, Pedro M.; Sanchez-Mateos, Juan Degado

    2014-01-01

    The present study provides information on the emotional experience of people with intellectual disability. To evaluate this emotional experience, we have used the International Affective Pictures System (IAPS). The most important result from this study is that the emotional reaction of people with intellectual disability to affective stimuli is…

  7. A Fast Version of LASG/IAP Climate System Model and Its 1000-year Control Integration

    Institute of Scientific and Technical Information of China (English)

    ZHOU Tianjun; WU Bo; WEN Xinyu; LI Lijuan; WANG Bin

    2008-01-01

    A fast version of the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geo- physical Fluid Dynamics (LASG)/Institute of Atmospheric Physics (IAP) climate system model is briefly documented. The fast coupled model employs a low resolution version of the atmospheric component Grid Atmospheric Model of IAP/LASG (GAMIL), with the other parts of the model, namely an oceanic com- ponent LASG/IAP Climate Ocean Model (LICOM), land component Common Land Model (CLM), and sea ice component from National Center for Atmospheric Research Community Climate System Model (NCAR CCSM2), as the same as in the standard version of LASG/IAP Flexible Global Ocean Atmosphere Land System model (FGOALS_g). The parameterizatious of physical and dynamical processes of the at- mospheric component in the fast version are identical to the standard version, although some parameter values are different. However, by virtue of reduced horizontal resolution and increased time-step of the most time-consuming atmospheric component, it runs faster by a factor of 3 and can serve as a useful tool for long- term and large-ensemble integrations. A 1000-year control simulation of the present-day climate has been completed without flux adjustments. The final 600 years of this simulation has virtually no trends in global mean sea surface temperatures and is recommended for internal variability studies. Several aspects of the control simulation's mean climate and variability axe evaluated against the observational or reanalysis data. The strengths and weaknesses of the control simulation are evaluated. The mean atmospheric circulation is well simulated, except in high latitudes. The Asian-Australian monsoonal meridional cell shows realistic features, however, an artificial rainfall center is located to the eastern periphery of the Tibetan Plateau persists throughout the year. The mean bias of SST resembles that of the standard version, appearing as a "double ITCZ" (Inter

  8. IAP family of cell death and signaling regulators.

    Science.gov (United States)

    Silke, John; Vucic, Domagoj

    2014-01-01

    Inhibitor of apoptosis (IAP) proteins interface with, and regulate a large number of, cell signaling pathways. If there is a common theme to these pathways, it is that they are involved in the development of the immune system, immune responses, and unsurprisingly, given their name, cell death. Beyond that it is difficult to discover an underlying logic because sometimes IAPs are required to inhibit or prevent signaling, whereas in other cases they are required for signaling to take place. In whatever role they play, they are recruited into signaling complexes and function as ubiquitin E3 ligases, via their RING domains. This review discusses IAP regulation of signaling pathways and focuses on the mammalian IAPs, XIAP, c-IAP1, and c-IAP2, with a particular emphasis on techniques and methods that were used to uncover their roles. We also provide a perspective on targeting IAP proteins for therapeutic intervention and methods used to define the clinical relevance of IAP proteins.

  9. Positive erotic picture stimuli for emotion research in heterosexual females.

    Science.gov (United States)

    Jacob, Gitta Anne; Arntz, Arnoud; Domes, Gregor; Reiss, Neele; Siep, Nicolette

    2011-12-30

    In most experimental studies, emotional pictures are widely used as stimulus material. However, there is still a lack of standardization of picture stimuli displaying erotic relationships, despite the association between a number of psychological problems and severe impairments and problems in intimate relationships. The aim of the study was to test a set of erotic stimuli, with the potential to be used in experimental studies, with heterosexual female subjects. Twenty International Affective Picture System (IAPS) pictures and an additional 100 pictures showing romantic but not explicitly sexual scenes and/or attractive single males were selected. All pictures were rated with respect to valence, arousal, and dominance by 41 heterosexual women and compared to pictures with negative, positive, and neutral emotional valence. Erotic IAPS pictures and our additional erotic pictures did not differ in any of the evaluation dimensions. Analyses of variance (ANOVAs) for valence, arousal, and dominance comparing different picture valence categories showed strong effects for category. However, valence was not significantly different between erotic and positive pictures, while arousal and control were not significantly different between positive and neutral pictures. The pictures of our new set are as positive for heterosexual women as highly positive IAPS pictures, but higher in arousal and dominance. The picture set can be used in experimental psychiatric studies requiring high numbers of stimuli per category. Limitations are the restriction of stimuli application to heterosexual females only and to self-report data. Copyright © 2011 Elsevier Ltd. All rights reserved.

  10. 21 CFR 892.2050 - Picture archiving and communications system.

    Science.gov (United States)

    2010-04-01

    ... Group (JPEG) Std., Society of Motion Picture and Television Engineers (SMPTE) Test Pattern). ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Picture archiving and communications system. 892... SERVICES (CONTINUED) MEDICAL DEVICES RADIOLOGY DEVICES Diagnostic Devices § 892.2050 Picture archiving...

  11. Picture models for 2-scene comics creating system

    Directory of Open Access Journals (Sweden)

    Miki UENO

    2015-03-01

    Full Text Available Recently, computer understanding pictures and stories becomes one of the most important research topics in computer science. However, there are few researches about human like understanding by computers because pictures have not certain format and contain more lyric aspect than that of natural laguage. For picture understanding, a comic is the suitable target because it is consisted by clear and simple plot of stories and separated scenes.In this paper, we propose 2 different types of picture models for 2-scene comics creating system. We also show the method of the application of 2-scene comics creating system by means of proposed picture model.

  12. Weak response of the Atlantic thermohaline circulation to an increase of atmospheric carbon dioxide in IAP/LASG Climate System Model

    Institute of Scientific and Technical Information of China (English)

    ZHOU Tianjun; YU Rucong; LIU Xiying; GUO Yufu; YU Yongqiang; ZHANG Xuehong

    2005-01-01

    Response of the Atlantic thermohaline circula- tion (THC) to global warming is examined by using the climate system model developed at IAP/LASG. The evidence indicates that the gradually warming climate associated with the increased atmospheric carbon dioxide leads to a warmer and fresher sea surface water at the high latitudes of the North Atlantic Ocean, which prevents the down-welling of the surface water. The succedent reduction of the pole-to- equator meridional potential density gradient finally results in the decrease of the THC in intensity. When the atmospheric carbon dioxide is doubled, the maximum value of the Atlantic THC decreases approximately by 8%. The associated poleward oceanic heat transport also becomes weaker. This kind of THC weakening centralizes mainly in the northern part of the North Atlantic basin, indicating briefly a local scale adjustment rather than a loop oscillation with the whole Atlantic "conveyor belt" decelerating.

  13. Reasons for Picture Archiving and Communication System (PACS ...

    African Journals Online (AJOL)

    Reasons for Picture Archiving and Communication System (PACS) data security ... breaches are nonintentionally committed by well-meaning employees during ... Methods: A closed-ended questionnaire was used to collect quantitative data ...

  14. Nephrogenic systemic fibrosis: clinical picture and treatment

    DEFF Research Database (Denmark)

    Marckmann, Peter; Skov, Lone

    2009-01-01

    The classic hallmark symptoms of advanced nephrogenic systemic fibrosis (NSF) (skin thickening, hardening and hyperpigmentation, and disabling contractures in renal failure patients) in temporal association with Gd-based contrast agent (GBCA) exposure are almost pathognomonic of NSF. Less obvious...

  15. A review of brain oscillations in perception of faces and emotional pictures.

    Science.gov (United States)

    Güntekin, Bahar; Başar, Erol

    2014-05-01

    The differentiation of faces, facial expressions and affective pictures involves processes of higher mental activity that have considerable applications in the psychology of moods and emotions. At present, the search for functional correlates of brain oscillations is an important trend in neuroscience. Furthermore, analyses of oscillatory responses provide key knowledge on the physiology of brain dynamics. Studies analysing oscillatory dynamics in face perception and emotional pictures have increased in recent years; however, the literature lacks a review of the current state of the art. This study provides a comprehensive review of the delta, theta, alpha, beta and gamma oscillatory responses on presentation of faces, facial expressions and affective pictures (International Affective Picture System, IAPS). The reviewed literature revealed that the brain is more sensitive to emotional stimuli than neutral stimuli. A common and reliable finding from all reviewed studies was the increased brain responsiveness towards negative emotional pictures (face expression or IAPS). Copyright © 2014 Elsevier Ltd. All rights reserved.

  16. Nephrogenic systemic fibrosis: clinical picture and treatment.

    Science.gov (United States)

    Marckmann, Peter; Skov, Lone

    2009-09-01

    The classic hallmark symptoms of advanced nephrogenic systemic fibrosis (NSF) (skin thickening, hardening and hyperpigmentation, and disabling contractures in renal failure patients) in temporal association with Gd-based contrast agent (GBCA) exposure are almost pathognomonic of NSF. Less obvious cases may be diagnosed on the basis of history of early GBCA-related NSF symptoms (warm swellings, pain, discoloration, itching of lower legs), signs of multiorgan involvement (lungs, nervous system), the exclusion of differential diagnoses, including scleromyxedema and systemic sclerosis, and the histology of deep skin biopsies. Symptomatic treatment with intensive physiotherapy and painkillers is important, but there is no known curative medical treatment. Spontaneous remission of NSF symptoms may occur with recovery of renal function after an episode of acute renal failure, or with kidney transplantation of chronic renal failure patients.

  17. Social systems: unearthing the big picture

    DEFF Research Database (Denmark)

    Cowley, Stephen

    2014-01-01

    Open peer commentary on the article “Social Autopoiesis?” by Hugo Urrestarazu. Upshot: Although accepting Urrestarazu’s view of how autopoietic dynamics can be sought in the domain of the non-living, we see no reason to trace the social to autonomy. Rather, we stress that social systems happen all...

  18. Single Integrated Air Picture (SIAP) Block 1 Candidate Systems

    Science.gov (United States)

    2007-11-02

    to produce joint warfighting capability. Since there was no process for the Single Integrated Air Picture System Engineering Task Force ( SIAP SE TF...to inherit or leverage, the SIAP SE TF had to build a process to identify candidate systems that will be impacted by the SIAP Block I upgrade.

  19. Heisenberg Picture Approach to the Stability of Quantum Markov Systems

    OpenAIRE

    Pan, Yu; Amini, Hadis; Miao, Zibo; Gough, John; Ugrinovskii, Valery; James, Matthew R.

    2014-01-01

    Quantum Markovian systems, modeled as unitary dilations in the quantum stochastic calculus of Hudson and Parthasarathy, have become standard in current quantum technological applications. This paper investigates the stability theory of such systems. Lyapunov-type conditions in the Heisenberg picture are derived in order to stabilize the evolution of system operators as well as the underlying dynamics of the quantum states. In particular, using the quantum Markov semigroup associated with this...

  20. Heisenberg picture approach to the stability of quantum Markov systems

    Energy Technology Data Exchange (ETDEWEB)

    Pan, Yu, E-mail: yu.pan@anu.edu.au, E-mail: zibo.miao@anu.edu.au; Miao, Zibo, E-mail: yu.pan@anu.edu.au, E-mail: zibo.miao@anu.edu.au [Research School of Engineering, Australian National University, Canberra, ACT 0200 (Australia); Amini, Hadis, E-mail: nhamini@stanford.edu [Edward L. Ginzton Laboratory, Stanford University, Stanford, California 94305 (United States); Gough, John, E-mail: jug@aber.ac.uk [Institute of Mathematics and Physics, Aberystwyth University, SY23 3BZ Wales (United Kingdom); Ugrinovskii, Valery, E-mail: v.ugrinovskii@gmail.com [School of Engineering and Information Technology, University of New South Wales at ADFA, Canberra, ACT 2600 (Australia); James, Matthew R., E-mail: matthew.james@anu.edu.au [ARC Centre for Quantum Computation and Communication Technology, Research School of Engineering, Australian National University, Canberra, ACT 0200 (Australia)

    2014-06-15

    Quantum Markovian systems, modeled as unitary dilations in the quantum stochastic calculus of Hudson and Parthasarathy, have become standard in current quantum technological applications. This paper investigates the stability theory of such systems. Lyapunov-type conditions in the Heisenberg picture are derived in order to stabilize the evolution of system operators as well as the underlying dynamics of the quantum states. In particular, using the quantum Markov semigroup associated with this quantum stochastic differential equation, we derive sufficient conditions for the existence and stability of a unique and faithful invariant quantum state. Furthermore, this paper proves the quantum invariance principle, which extends the LaSalle invariance principle to quantum systems in the Heisenberg picture. These results are formulated in terms of algebraic constraints suitable for engineering quantum systems that are used in coherent feedback networks.

  1. Heisenberg picture approach to the stability of quantum Markov systems

    Science.gov (United States)

    Pan, Yu; Amini, Hadis; Miao, Zibo; Gough, John; Ugrinovskii, Valery; James, Matthew R.

    2014-06-01

    Quantum Markovian systems, modeled as unitary dilations in the quantum stochastic calculus of Hudson and Parthasarathy, have become standard in current quantum technological applications. This paper investigates the stability theory of such systems. Lyapunov-type conditions in the Heisenberg picture are derived in order to stabilize the evolution of system operators as well as the underlying dynamics of the quantum states. In particular, using the quantum Markov semigroup associated with this quantum stochastic differential equation, we derive sufficient conditions for the existence and stability of a unique and faithful invariant quantum state. Furthermore, this paper proves the quantum invariance principle, which extends the LaSalle invariance principle to quantum systems in the Heisenberg picture. These results are formulated in terms of algebraic constraints suitable for engineering quantum systems that are used in coherent feedback networks.

  2. Antagonists of IAP proteins as cancer therapeutics.

    Science.gov (United States)

    Dynek, Jasmin N; Vucic, Domagoj

    2013-05-28

    Inhibitor of apoptosis (IAP) proteins play pivotal roles in cellular survival by blocking apoptosis, modulating signal transduction, and affecting cellular proliferation. Through their interactions with inducers and effectors of apoptosis IAP proteins can effectively suppress apoptosis triggered by diverse stimuli including death receptor signaling, irradiation, chemotherapeutic agents, or growth factor withdrawal. Evasion of apoptosis, in part due to the action of IAP proteins, enhances resistance of cancer cells to treatment with chemotherapeutic agents and contributes to tumor progression. Additionally, IAP genes are known to be subject to amplification, mutation, and chromosomal translocation in human malignancies and autoimmune diseases. In this review we will discuss the role of IAP proteins in cancer and the development of antagonists targeting IAP proteins for cancer treatment.

  3. Infrastructure design of a picture archiving and communication system.

    Science.gov (United States)

    Huang, H K; Taira, R K

    1992-04-01

    A picture archiving and communication system (PACS) infrastructure is the necessary framework to integrate distributed and heterogeneous imaging systems, provide intelligent data-base management of all radiology-related information, arrange an efficient means of viewing, analyzing, and documenting study results, and furnish a mechanism for effectively communicating study results to the referring physician. The PACS infrastructure consists of a basic skeleton of hardware components integrated by standardized, flexible software subsystems. This review describes these concepts and basic building blocks drawn from our original investigation, past experience, and the current clinical system in our radiology department.

  4. The Design of Intelligent Temperature Control System Based on MCU IAP15 F2 K61 S2%基于IAP15 F2 K61 S2的智能温度控制系统设计

    Institute of Scientific and Technical Information of China (English)

    王亚娟; 郭丹; 董春梅; 徐荣梦

    2015-01-01

    本文阐述了智能温度控制系统主要实现两部分功能来设计:一是利用温度传感器测量水温,当水温低于设定的温度值时,继电器闭合,加热器加热,待水温升至预定水温时,继电器断开,蜂鸣器报警,停止加热;二是利用液位传感器测量当前液面高度,当液面高度低于设定的液面下限或超出设定的液面上限,蜂鸣器报警。本次设计的核心单片机为IAP15F2K61S2,温度传感器选用防水型DS18B20,液位传感器选用超声波传感器。%In this paper the temperature control system have two main functions. One is the temperature will be measured with temperature sensor, when the temperature is below the set value, the relay is closed and the heater is heating, when the temperature is equal to the set value, the relay open and the buzzer is alarm and the heater is not heating . Secondly, liquid level sensor is measuring the liquid surface height, when the height is lower than set lower limit or exceeds the maximum temperature, the buzzer alarm. The main microcomputer is MCU IAP15F2K61S2, temperature sensor is DS18B20 , liquid level sensor is based on the ultrasonic sensor.

  5. Evaluating Picture Quality of Image Plates in Digital CR Systems

    Energy Technology Data Exchange (ETDEWEB)

    Kwak, Byung Joon [Dept. of Radiological Tecnology, Choonhae College of Health Science, Ulsan (Korea, Republic of); Ji Tae Jeong [Dept. of Radiological Science, Kaya University, Kimhae (Korea, Republic of)

    2011-12-15

    Lab effectively supplemented the effects of outside radiation on image plates in the process of image acquisition of CR (computed radiography) systems and conducted for effective utilization in the case of clinical application. For this, Lab classified the storage places and time periods of image plates and compared and analyzed the differences between small dark spots. Lab also assessed the concentration distribution within the boundaries of images. Lab compared and measured the number of dark spots in a light room and a dark room depending on the storage places of image plates and found that dark spots slightly increased in an image plate when stored in a light room on the first and second days. Dark spots increased in proportion to the length of time stored. In the case of the image plate stored in a dark room, the number of dark spots remarkably decreased. With regard to picture quality as related to the location of image plates, the damage to picture quality could be reduced by locating regions of interest in the center. With regard to differences in sharpness following changes in the thickness of subjects, fewer scatter rays occurred and sharpness improved by reducing the thickness of subjects as much as possible. To get medical images of excellent quality, image plates should be managed effectively and it is desirable to keep images plates in dark iron plate boxes and not to expose them to outside radiation for a long time.

  6. Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2.

    Science.gov (United States)

    Darding, M; Feltham, R; Tenev, T; Bianchi, K; Benetatos, C; Silke, J; Meier, P

    2011-08-01

    The inhibitors of apoptosis (IAP) proteins cIAP1 and cIAP2 have recently emerged as key ubiquitin-E3 ligases regulating innate immunity and cell survival. Much of our knowledge of these IAPs stems from studies using pharmacological inhibitors of IAPs, dubbed Smac mimetics (SMs). Although SMs stimulate auto-ubiquitylation and degradation of cIAPs, little is known about the molecular determinants through which SMs activate the E3 activities of cIAPs. In this study, we find that SM-induced rapid degradation of cIAPs requires binding to tumour necrosis factor (TNF) receptor-associated factor 2 (TRAF2). Moreover, our data reveal an unexpected difference between cIAP1 and cIAP2. Although SM-induced degradation of cIAP1 does not require cIAP2, degradation of cIAP2 critically depends on the presence of cIAP1. In addition, degradation of cIAP2 also requires the ability of the cIAP2 RING finger to dimerise and to bind to E2s. This has important implications because SM-mediated degradation of cIAP1 causes non-canonical activation of NF-κB, which results in the induction of cIAP2 gene expression. In the absence of cIAP1, de novo synthesised cIAP2 is resistant to the SM and suppresses TNFα killing. Furthermore, the cIAP2-MALT1 oncogene, which lacks cIAP2's RING, is resistant to SM treatment. The identification of mechanisms through which cancer cells resist SM treatment will help to improve combination therapies aimed at enhancing treatment response.

  7. Picture archiving and communication systems in digital cytology.

    Science.gov (United States)

    Morelli, Sandra; Grigioni, Mauro; Giovagnoli, Maria Rosaria; Balzano, Simone; Giansanti, Daniele

    2010-01-01

    The paper describes a fundamental feature of digital cytology relevant to the implementation of the technology in the hospital net services: the electronic recording of the virtual slides (VS) in the hospital information system (HIS) through a picture archiving and communication system (PACS). Starting from the digital cytology (D-CYT) state of art and considering the most important products in the field, particular attention has been devoted in this review to the comparison with the digital radiology (D-RAD). Two main indications emerged from the study: 1. there is not a standard in the digital files relevant to the virtual slides in D-CYT, while in D-RAD the standard digital imaging and communications in medicine (DICOM), introduced by the National Electrical Manufacturers Association (NEMA), has been adopted from several years; 2. the PACS in D-CYT are not standardized from manufacturers. The study makes a proposal of a useful software architecture to improve the PACS integration for D-CYT applications, with potentialities in the HIS.

  8. Picture archiving and communication systems in digital cytology

    Directory of Open Access Journals (Sweden)

    Sandra Morelli

    2010-06-01

    Full Text Available The paper describes a fundamental feature of digital cytology relevant to the implementation of the technology in the hospital net services: the electronic recording of the virtual slides (VS in the hospital information system (HIS through a picture archiving and communication system (PACS. Starting from the digital cytology (D-CYT state of art and considering the most important products in the field, particular attention has been devoted in this review to the comparison with the digital radiology (D-RAD. Two main indications emerged from the study: 1. there is not a standard in the digital files relevant to the virtual slides in D-CYT, while in D-RAD the standard digital imaging and communications in medicine (DICOM, introduced by the National Electrical Manufacturers Association (NEMA, has been adopted from several years; 2. the PACS in D-CYT are not standardized from manufacturers. The study makes a proposal of a useful software architecture to improve the PACS integration for D-CYT applications, with potentialities in the HIS.

  9. Semi-supervised classification of emotional pictures based on feature combination

    Science.gov (United States)

    Li, Shuo; Zhang, Yu-Jin

    2011-02-01

    Can the abundant emotions reflected in pictures be classified automatically by computer? Only the visual features extracted from images are considered in the previous researches, which have the constrained capability to reveal various emotions. In addition, the training database utilized by previous methods is the subset of International Affective Picture System (IAPS) that has a relatively small scale, which exerts negative effects on the discrimination of emotion classifiers. To solve the above problems, this paper proposes a novel and practical emotional picture classification approach, using semi-supervised learning scheme with both visual feature and keyword tag information. Besides the IAPS with both emotion labels and keyword tags as part of the training dataset, nearly 2000 pictures with only keyword tags that are downloaded from the website Flickr form an auxiliary training dataset. The visual feature of the latent emotional semantic factors is extracted by probabilistic Latent Semantic Analysis (pLSA) model, while the text feature is described by binary vectors on the tag vocabulary. A first Linear Programming Boost (LPBoost) classifier which is trained on the samples from IAPS combines the above two features, and aims to label the other training samples from the internet. Then the second SVM classifier which is trained on all training images using only visual feature, focuses on the test images. In the experiment, the categorization performance of our approach is better than the latest methods.

  10. ITS: a practical picture archiving and communication system

    Science.gov (United States)

    Lei, Tianhu; Sewchand, Wilfred

    1990-09-01

    (only) In the design and implementation of Picture Archiving and Communication Systems (PACS) two types of problems have to be solved. The first is in the aspect of image data formatting and the second is in the image transmission. Radiography X-ray Computed Tomography (CT) radionuclide emission tomography magnetic resonance imaging (MRI) and ultrasonic imaging are the widely used medical imaging. Microscopic images are the examples of bioimaging. Some of these biomedical imaging modalities such as X-ray CT MRI etc directly create digitized images which are stored in computer disks. Some of them produce non-digitized images which are recorded on films or video-tapes. Using scanners (flatbed overhead slide) or video camera the non-digitized images can be digitized. Due to the diversity of physical principles and image reconstruction procedures of these imaging modalities the image data formats of the digitized biomedical images are extremely different. In addition the data size of the digitized images are usually very large especially when the higher resolution is required. For instance a transaxial thoracic image created by the 3-ni generation of X-ray scanner has about 150 x i03 bytes a digitized radiographic film (14" x 17" ) in the moderate resolution (300 pixel-per-inch) occupies about 20 x 106 bytes. Therefore seeking an unified image data format and compressing the image data for digitized biomedical images are the first issue in developing PACS. Computer networks provide the effective

  11. Meet OLAF, a good friend of the IAPS! The Open Library of Affective Foods: a tool to investigate the emotional impact of food in adolescents.

    Science.gov (United States)

    Miccoli, Laura; Delgado, Rafael; Rodríguez-Ruiz, Sonia; Guerra, Pedro; García-Mármol, Eduardo; Fernández-Santaella, M Carmen

    2014-01-01

    In the last decades, food pictures have been repeatedly employed to investigate the emotional impact of food on healthy participants as well as individuals who suffer from eating disorders and obesity. However, despite their widespread use, food pictures are typically selected according to each researcher's personal criteria, which make it difficult to reliably select food images and to compare results across different studies and laboratories. Therefore, to study affective reactions to food, it becomes pivotal to identify the emotional impact of specific food images based on wider samples of individuals. In the present paper we introduce the Open Library of Affective Foods (OLAF), which is a set of original food pictures created to reliably select food pictures based on the emotions they prompt, as indicated by affective ratings of valence, arousal, and dominance and by an additional food craving scale. OLAF images were designed to allow simultaneous use with affective images from the International Affective Picture System (IAPS), which is a well-known instrument to investigate emotional reactions in the laboratory. The ultimate goal of the OLAF is to contribute to understanding how food is emotionally processed in healthy individuals and in patients who suffer from eating and weight-related disorders. The present normative data, which was based on a large sample of an adolescent population, indicate that when viewing affective non-food IAPS images, valence, arousal, and dominance ratings were in line with expected patterns based on previous emotion research. Moreover, when viewing food pictures, affective and food craving ratings were consistent with research on food cue processing. As a whole, the data supported the methodological and theoretical reliability of the OLAF ratings, therefore providing researchers with a standardized tool to reliably investigate the emotional and motivational significance of food. The OLAF database is publicly available at zenodo.org.

  12. Meet OLAF, a good friend of the IAPS! The Open Library of Affective Foods: a tool to investigate the emotional impact of food in adolescents.

    Directory of Open Access Journals (Sweden)

    Laura Miccoli

    Full Text Available In the last decades, food pictures have been repeatedly employed to investigate the emotional impact of food on healthy participants as well as individuals who suffer from eating disorders and obesity. However, despite their widespread use, food pictures are typically selected according to each researcher's personal criteria, which make it difficult to reliably select food images and to compare results across different studies and laboratories. Therefore, to study affective reactions to food, it becomes pivotal to identify the emotional impact of specific food images based on wider samples of individuals. In the present paper we introduce the Open Library of Affective Foods (OLAF, which is a set of original food pictures created to reliably select food pictures based on the emotions they prompt, as indicated by affective ratings of valence, arousal, and dominance and by an additional food craving scale. OLAF images were designed to allow simultaneous use with affective images from the International Affective Picture System (IAPS, which is a well-known instrument to investigate emotional reactions in the laboratory. The ultimate goal of the OLAF is to contribute to understanding how food is emotionally processed in healthy individuals and in patients who suffer from eating and weight-related disorders. The present normative data, which was based on a large sample of an adolescent population, indicate that when viewing affective non-food IAPS images, valence, arousal, and dominance ratings were in line with expected patterns based on previous emotion research. Moreover, when viewing food pictures, affective and food craving ratings were consistent with research on food cue processing. As a whole, the data supported the methodological and theoretical reliability of the OLAF ratings, therefore providing researchers with a standardized tool to reliably investigate the emotional and motivational significance of food. The OLAF database is publicly

  13. Recent Advances in Dynamical Extra-Seasonal to Annual Climate Prediction at IAP/CAS

    Institute of Scientific and Technical Information of China (English)

    林朝晖; 王会军; 周广庆; 陈红; 郎咸梅; 赵彦; 曾庆存

    2004-01-01

    Recent advances in dynamical climate prediction at the Institute of Atmospheric Physics, Chinese Academy of Sciences (IAP/CAS) during the last five years have been briefly described in this paper. Firstly,the second generation of the IAP dynamical climate prediction system (IAP DCP-Ⅱ) has been described,and two sets of hindcast experiments of the summer rainfall anomalies over China for the periods of 1980-1994 with different versions of the IAP AGCM have been conducted. The comparison results show that the predictive skill of summer rainfall anomalies over China is improved with the improved IAP AGCM in which the surface albedo parameterization is modified. Furthermore, IAP DCP-Ⅱ has been applied to the real-time prediction of summer rainfall anomalies over China since 1998, and the verification results show that IAP DCP-Ⅱ can quite well capture the large scale patterns of the summer flood/drought situations over China during the last five years (1998-2002). Meanwhile, an investigation has demonstrated the importance of the atmospheric initial conditions on the seasonal climate prediction, along with studies on the influences from surface boundary conditions (e.g., land surface characteristics, sea surface temperature).Certain conclusions have been reached, such as, the initial atmospheric anomalies in spring may play an important role in the summer climate anomalies, and soil moisture anomalies in spring can also have a significant impact on the summer climate anomalies over East Asia. Finally, several practical techniques (e.g., ensemble technique, correction method, etc.), which lead to the increase of the prediction skill for summer rainfall anomalies over China, have also been illustrated. The paper concludes with a list of critical requirements needed for the further improvement of dynamical seasonal climate prediction.

  14. A multiprocessor system for the analysis of pictures of nuclear events

    CERN Document Server

    Bacilieri, P; Matteuzzi, P; Sini, G P; Zanotti, U

    1979-01-01

    The pictures of nuclear events obtained from the bubble chambers such as Gargamelle and BEBC at CERN and others from Serpukhov are geometrically processed at CNAF (Centro Nazionale Analysis Photogrammi) in Bologna. The analysis system includes an Erasme table and a CRT flying spot digitizer. The difficulties connected with the pictures of the four stereoscopic views of the bubble chambers are overcome by the choice of a strong interactive system. (0 refs).

  15. Development of picture quality monitoring system for IPTV service based on the reduced reference framework

    Science.gov (United States)

    Sugimoto, Osamu; Kawada, Ryoichi; Koike, Atsushi

    2006-01-01

    The authors developed a software-based realtime IPTV monitoring system based on Reduced Reference framework, and evaluated the proposed system. One of the quality issues of the IPTV service is the picture quality degradation caused by packet loss. The proposed system precisely estimates the PSNR of the corrupted received picture by extracting and comparing image features from transmission and receiver side. Computer simulations show that PSNR estimation with a 0.945 correlation coefficient at a data channel bitrate of 36kbps is possible using the proposed system.

  16. A Prototype Multi-Modality Picture Archive And Communication System At Victoria General Hospital

    Science.gov (United States)

    Nosil, J.; Justice, G.; Fisher, P.; Ritchie, G.; Weigl, W. J.; Gnoyke, H.

    1988-06-01

    The Medical Imaging Department at Victoria General Hospital is the first in Canada to implement an integrated multi-modality picture archive and communication system for clinical use. The aim of this paper is to present the current status of the picture archive and communication system components and to describe its function. This system was installed in April of 1987, and upgraded in November of 1987. A picture archive and communication system includes image sources, an image management system, and image display and reporting facilities. The installed image sources (digital radiography, digital fluoroscopy, computed tomography, and digital subtraction angiography) provide digital data for the image management system. The image management system provides facilities for receiving, storing, retrieving, and transmitting images using conventional computers and networks. There are two display stations, a viewing console and an image processing workstation, which provide various image display and manipulation functions. In parallel with the implementation of the picture archive and communication system there are clinical, physical, and economic evaluations being pursued. An initial examination of digital image transfer rates indicate that users will experience similar image availability times as with conventional film imaging. Clinical experience to date with the picture archive and communication system has been limited to that required to evaluate digital imaging as a diagnostic tool, using digital radiography and digital fluoroscopy studies. Computed tomography and digital subtraction angiography have only recently been connected to the picture archive and communication system. Clinical experience with these modalities is limited to several cases, but image fidelity appears to be well above clinically acceptable levels.

  17. Targeting IAP proteins for therapeutic intervention in cancer.

    Science.gov (United States)

    Fulda, Simone; Vucic, Domagoj

    2012-02-01

    Evasion of apoptosis is one of the crucial acquired capabilities used by cancer cells to fend off anticancer therapies. Inhibitor of apoptosis (IAP) proteins exert a range of biological activities that promote cancer cell survival and proliferation. X chromosome-linked IAP is a direct inhibitor of caspases - pro-apoptotic executioner proteases - whereas cellular IAP proteins block the assembly of pro-apoptotic protein signalling complexes and mediate the expression of anti-apoptotic molecules. Furthermore, mutations, amplifications and chromosomal translocations of IAP genes are associated with various malignancies. Among the therapeutic strategies that have been designed to target IAP proteins, the most widely used approach is based on mimicking the IAP-binding motif of second mitochondria-derived activator of caspase (SMAC), which functions as an endogenous IAP antagonist. Alternative strategies include transcriptional repression and the use of antisense oligonucleotides. This Review provides an update on IAP protein biology as well as current and future perspectives on targeting IAP proteins for therapeutic intervention in human malignancies.

  18. Global Picture Archiving and Communication Systems (GPACS): An Overview

    Science.gov (United States)

    1994-04-01

    one value, not a list of values at every row-column position). A relational algebra , presented by Codd, that consists of a collection of high-level...Prescription for Spiraling Health Costs; Billing Systems are Just the Start.", InfoWorld, Feb 15 v15 n7, 1-2, 1993. Cardenas , A. F. "Pictorial/Visual Acess to

  19. Use of the adult attachment projective picture system in psychodynamic psychotherapy with a severely traumatized patient.

    Science.gov (United States)

    George, Carol; Buchheim, Anna

    2014-01-01

    The following case study is presented to facilitate an understanding of how the attachment information evident from Adult Attachment Projective Picture System (AAP) assessment can be integrated into a psychodynamic perspective in making therapeutic recommendations that integrate an attachment perspective. The Adult Attachment Projective Picture System (AAP) is a valid representational measure of internal representations of attachment based on the analysis of a set of free response picture stimuli designed to systematically activate the attachment system (George and West, 2012). The AAP provides a fruitful diagnostic tool for psychodynamic-oriented clinicians to identify attachment-based deficits and resources for an individual patient in therapy. This paper considers the use of the AAP with a traumatized patient in an inpatient setting and uses a case study to illustrate the components of the AAP that are particularly relevant to a psychodynamic conceptualization. The paper discusses also attachment-based recommendations for intervention.

  20. Development and implementation of ultrasound picture archiving and communication system

    Science.gov (United States)

    Weinberg, Wolfram S.; Tessler, Franklin N.; Grant, Edward G.; Kangarloo, Hooshang; Huang, H. K.

    1990-08-01

    The Department of Radiological Sciences at the UCLA School of Medicine is developing an archiving and communication system (PACS) for digitized ultrasound images. In its final stage the system will involve the acquisition and archiving of ultrasound studies from four different locations including the Center for Health Sciences, the Department for Mental Health and the Outpatient Radiology and Endoscopy Departments with a total of 200-250 patient studies per week. The concept comprises two stages of image manipulation for each ultrasound work area. The first station is located close to the examination site and accomodates the acquisition of digital images from up to five ultrasound devices and provides for instantaneous display and primary viewing and image selection. Completed patient studies are transferred to a main workstation for secondary review, further analysis and comparison studies. The review station has an on-line storage capacity of 10,000 images with a resolution of 512x512 8 bit data to allow for immediate retrieval of active patient studies of up to two weeks. The main work stations are connected through the general network and use one central archive for long term storage and a film printer for hardcopy output. First phase development efforts concentrate on the implementation and testing of a system at one location consisting of a number of ultrasound units with video digitizer and network interfaces and a microcomputer workstation as host for the display station with two color monitors, each allowing simultaneous display of four 512x512 images. The discussion emphasizes functionality, performance and acceptance of the system in the clinical environment.

  1. General flat four-dimensional world pictures and clock systems

    Science.gov (United States)

    Hsu, J. P.; Underwood, J. A.

    1978-01-01

    We explore the mathematical structure and the physical implications of a general four-dimensional symmetry framework which is consistent with the Poincare-Einstein principle of relativity for physical laws and with experiments. In particular, we discuss a four-dimensional framework in which all observers in different frames use one and the same grid of clocks. The general framework includes special relativity and a recently proposed new four-dimensional symmetry with a nonuniversal light speed as two special simple cases. The connection between the properties of light propagation and the convention concerning clock systems is also discussed, and is seen to be nonunique within the four-dimensional framework.

  2. Video Feedforward for Rapid Learning of a Picture-Based Communication System

    Science.gov (United States)

    Smith, Jemma; Hand, Linda; Dowrick, Peter W.

    2014-01-01

    This study examined the efficacy of video self modeling (VSM) using feedforward, to teach various goals of a picture exchange communication system (PECS). The participants were two boys with autism and one man with Down syndrome. All three participants were non-verbal with no current functional system of communication; the two children had long…

  3. A New Forensic Picture Polygraph Technique for Terrorist and Crime Deception System

    Science.gov (United States)

    Costello, R. H. Brian; Axton, JoAnn; Gold, Karen L.

    2006-01-01

    The Forensic Terrorist Detection System called Pinocchio Assessment Profile (PAP) employs standard issue polygraphs for a non-verbal picture technique originated as a biofeedback careers interest instrument. The system can be integrated readily into airport screening protocols. However, the method does not rely on questioning or foreign language…

  4. Video Feedforward for Rapid Learning of a Picture-Based Communication System

    Science.gov (United States)

    Smith, Jemma; Hand, Linda; Dowrick, Peter W.

    2014-01-01

    This study examined the efficacy of video self modeling (VSM) using feedforward, to teach various goals of a picture exchange communication system (PECS). The participants were two boys with autism and one man with Down syndrome. All three participants were non-verbal with no current functional system of communication; the two children had long…

  5. An Evaluation of Strategies for Training Staff to Implement the Picture Exchange Communication System

    Science.gov (United States)

    Barnes, Clarissa S.; Dunning, Johnna L.; Rehfeldt, Ruth Anne

    2011-01-01

    The picture exchange communication system (PECS) is a functional communication system frequently used with individuals diagnosed with autism spectrum disorders who experience severe language delays (Frost & Bondy, 2002). Few empirical investigations have evaluated strategies for training direct care staff how to effectively implement PECS with…

  6. The Effects of Behavioral Skills Training on Implementation of the Picture Exchange Communication System

    Science.gov (United States)

    Rosales, Rocio; Stone, Karen; Rehfeldt, Ruth Anne

    2009-01-01

    The effectiveness of a behavioral skills training (BST) package to teach the implementation of the first three phases of the picture exchange communication system (PECS) was evaluated with 3 adults who had no history teaching any functional communication system. A multiple baseline design across participants was used to evaluate the effectiveness…

  7. Characterization of ML-IAP protein stability and physiological role in vivo.

    Science.gov (United States)

    Varfolomeev, Eugene; Moradi, Elham; Dynek, Jasmin N; Zha, Jiping; Fedorova, Anna V; Deshayes, Kurt; Fairbrother, Wayne J; Newton, Kim; Le Couter, Jennifer; Vucic, Domagoj

    2012-11-01

    ML-IAP [melanoma IAP (inhibitor of apoptosis)] is an anti-apoptotic protein that is expressed highly in melanomas where it contributes to resistance to apoptotic stimuli. The anti-apoptotic activity and elevated expression of IAP family proteins in many human cancers makes IAP proteins attractive targets for inhibition by cancer therapeutics. Small-molecule IAP antagonists that bind with high affinities to select BIR (baculovirus IAP repeat) domains have been shown to stimulate auto-ubiquitination and rapid proteasomal degradation of c-IAP1 (cellular IAP1) and c-IAP2 (cellular IAP2). In the present paper, we report ML-IAP proteasomal degradation in response to bivalent, but not monovalent, IAP antagonists. This degradation required ML-IAP ubiquitin ligase activity and was independent of c-IAP1 or c-IAP2. Although ML-IAP is best characterized in melanoma cells, we show that ML-IAP expression in normal mammalian tissues is restricted largely to the eye, being most abundant in ciliary body epithelium and retinal pigment epithelium. Surprisingly, given this pattern of expression, gene-targeted mice lacking ML-IAP exhibited normal intraocular pressure as well as normal retinal structure and function. The results of the present study indicate that ML-IAP is dispensable for both normal mouse development and ocular homoeostasis.

  8. Influence of trait behavioral inhibition and behavioral approach motivation systems on the LPP and frontal asymmetry to anger pictures.

    Science.gov (United States)

    Gable, Philip A; Poole, Bryan D

    2014-02-01

    Behavioral approach and avoidance are fundamental to the experience of emotion and motivation, but the motivational system associated with anger is not well established. Some theories posit that approach motivational processes underlie anger, whereas others posit that avoidance motivational processes underlie anger. The current experiment sought to address whether traits related to behavioral approach or avoidance influence responses to anger stimuli using multiple measures: ERP, electroencephalographic (EEG) α-asymmetry and self-report. After completing the behavioral inhibition system/behavioral approach system (BIS/BAS) scales, participants viewed anger pictures and neutral pictures. BAS predicted larger late positive potentials (LPPs) to anger pictures, but not to neutral pictures. In addition, BAS predicted greater left-frontal asymmetry to anger pictures. Moreover, larger LPPs to anger pictures related to greater left-frontal EEG asymmetry during anger pictures. These results suggest that trait approach motivation relates to neurophysiological responses of anger.

  9. IAP proteins as targets for drug development in oncology

    Directory of Open Access Journals (Sweden)

    Dubrez L

    2013-09-01

    Full Text Available Laurence Dubrez,1,2 Jean Berthelet,1,2 Valérie Glorian,1,21Institut National de la Santé et de la Recherche Médicale (Inserm, Dijon, France; 2Université de Bourgogne, Dijon, FranceAbstract: The inhibitors of apoptosis (IAPs constitute a family of proteins involved in the regulation of various cellular processes, including cell death, immune and inflammatory responses, cell proliferation, cell differentiation, and cell motility. There is accumulating evidence supporting IAP-targeting in tumors: IAPs regulate various cellular processes that contribute to tumor development, such as cell death, cell proliferation, and cell migration; their expression is increased in a number of human tumor samples, and IAP overexpression has been correlated with tumor growth, and poor prognosis or low response to treatment; and IAP expression can be rapidly induced in response to chemotherapy or radiotherapy because of the presence of an internal ribosome entry site (IRES-dependent mechanism of translation initiation, which could contribute to resistance to antitumor therapy. The development of IAP antagonists is an important challenge and was subject to intense research over the past decade. Six molecules are currently in clinical trials. This review focuses on the role of IAPs in tumors and the development of IAP-targeting molecules for anticancer therapy.Keywords: Smac mimetics, apoptosis, antitumor therapy

  10. Quantitative Synthesis and Component Analysis of Single-Participant Studies on the Picture Exchange Communication System

    Science.gov (United States)

    Tincani, Matt; Devis, Kathryn

    2011-01-01

    The "Picture Exchange Communication System" (PECS) has emerged as the augmentative communication intervention of choice for individuals with autism spectrum disorder (ASD), with a supporting body of single-participant studies. This report describes a meta-analysis of 16 single-participant studies on PECS with percentage of nonoverlapping data…

  11. Understanding the Picture Exchange Communication System and Its Application in Physical Education

    Science.gov (United States)

    Green, Amanda; Sandt, Dawn

    2013-01-01

    This article presents the Picture Exchange Communication System (PECS) and its applications in physical education. The PECS is an appropriate communication intervention for students with autism who lack functional communication skills. It is often confused with other visual support strategies, so the authors delineate the six phases of PECS and…

  12. Using the Picture Exchange Communication System with Students with Visual Impairment

    Science.gov (United States)

    Ivy, Sarah E.; Hatton, Deborah D.; Hooper, Jonathan D.

    2014-01-01

    Students with visual impairment (VI) were taught to request using the Picture Exchange Communication System (PECS) and tangible symbols. Participants were four males with additional disabilities, 5 to 11 years old, who had little to no functional vision. A functional relation between PECS Phase 1 and requesting was established using a multiple…

  13. Transparent image access in a distributed picture archiving and communications system: The master database broker

    OpenAIRE

    Cox, R D; Henri, C. J.; Rubin, R. K.

    1999-01-01

    A distributed design is the most cost-effective system for small- to medium-scale picture archiving and communications systems (PACS) implementations. However, the design presents an interesting challenge to developers and implementers: to make stored image data, distributed throughout the PACS network, appear to be centralized with a single access point for users. A key component for the distributed system is a central or master database, containing all the studies that have been scanned int...

  14. Development of rebunching cavities at IAP

    CERN Document Server

    Welsch, C P; Schempp, A

    2000-01-01

    A focus of work at IAP has been the development and optimization of spiral loaded cavities since the 1970s [A. Schempp et al, NIM 135, 409 (1976)]. These cavities feature a high efficiency, a compact design and a big variety of possible fields of application. They find use both as bunchers and post accelerators to vary the final energy of the beam. In comparison to other available designs, the advantage of these structures lies in their small size. Furthermore they can easily be tuned to the required resonance frequency by varying the length of the spiral. Due to the small size of the cavities the required budget can also be kept low. Here, two slightly different types of spiral loaded cavities, which were built for the REX-ISOLDE project at CERN and the intensity upgrade program at GSI are being discussed.

  15. The amodal system for conscious word and picture identification in the absence of a semantic task.

    Science.gov (United States)

    Van Doren, Leen; Dupont, Patrick; De Grauwe, Sophie; Peeters, Ronald; Vandenberghe, Rik

    2010-02-15

    Previous studies using explicit semantic tasks, such as category or similarity judgments, have revealed considerable neuroanatomical overlap between processing of the meaning of words and pictures. This result may have been influenced by the semantic executive control required by such tasks. We examined the degree of overlap while minimizing semantic executive demands. In a first fMRI experiment (n=28), we titrated word (35.3 ms, SD=9.6) and picture presentation duration (50.7 ms, SD=15.8) such that conscious stimulus identification became a stochastic process, with a 50% chance of success. Subjects had to indicate by key press whether or not they had been able to identify the stimulus. In a second fMRI experiment (n=19), the identification runs were followed by a surprise forced-choice recognition task and events were sorted on the basis of subsequent memory retrieval success rather than a subjective consciousness report. For both words and pictures, when stimulus processing exceeded the conscious identification threshold, the left occipitotemporal sulcus (OTS), intraparietal sulcus, inferior frontal junction, and middle third of the inferior frontal sulcus (IFS) were more active than when subjects had been unable to identify the stimulus. For both words and pictures, activity in two of these regions, IFS and OTS, predicted subsequent memory retrieval success. A Bayesian comparison revealed that the effective connectivity between IFS and the word- or picture-specific systems was mainly mediated via its connections with OTS. The amodal nature of left OTS and IFS involvement in word and picture processing extends to tasks with minimal semantic executive demands.

  16. Viewing pictures of a romantic partner reduces experimental pain: involvement of neural reward systems.

    Directory of Open Access Journals (Sweden)

    Jarred Younger

    Full Text Available The early stages of a new romantic relationship are characterized by intense feelings of euphoria, well-being, and preoccupation with the romantic partner. Neuroimaging research has linked those feelings to activation of reward systems in the human brain. The results of those studies may be relevant to pain management in humans, as basic animal research has shown that pharmacologic activation of reward systems can substantially reduce pain. Indeed, viewing pictures of a romantic partner was recently demonstrated to reduce experimental thermal pain. We hypothesized that pain relief evoked by viewing pictures of a romantic partner would be associated with neural activations in reward-processing centers. In this functional magnetic resonance imaging (fMRI study, we examined fifteen individuals in the first nine months of a new, romantic relationship. Participants completed three tasks under periods of moderate and high thermal pain: 1 viewing pictures of their romantic partner, 2 viewing pictures of an equally attractive and familiar acquaintance, and 3 a word-association distraction task previously demonstrated to reduce pain. The partner and distraction tasks both significantly reduced self-reported pain, although only the partner task was associated with activation of reward systems. Greater analgesia while viewing pictures of a romantic partner was associated with increased activity in several reward-processing regions, including the caudate head, nucleus accumbens, lateral orbitofrontal cortex, amygdala, and dorsolateral prefrontal cortex--regions not associated with distraction-induced analgesia. The results suggest that the activation of neural reward systems via non-pharmacologic means can reduce the experience of pain.

  17. Radiology information systems, picture archiving and communication systems, teleradiology--overview and design criteria.

    Science.gov (United States)

    Roberson, G H; Shieh, Y Y

    1998-11-01

    Information technology (IT), long taken for granted in commercial settings, is now being utilized for health-care applications. Medical imaging has lagged comparatively due to the extremely vast data content of each frame; thus, the requirement for expensive high-end components. Further, IT in radiology has evolved from two distinctly separate camps--information systems, known as RIS (radiology information systems) and PACS (picture archiving and communications systems). Both RIS and PACS applications have migrated to the PC environment, enabling cost-effective implementation, but from two backgrounds: RIS from vendors using conventional information systems platforms and products, and PACS from radiographic film and modality vendors. The radiology department at Texas Tech University has assembled a seamlessly integrated, enterprise-wide RIS/PACS/teleradiology intranet. The design criteria include user-friendliness, flexibility to respond to changing needs, and open modular architecture to assure interoperability, cost-effectiveness, and future-proofing of investment. Since no single venor could provide an integrated system meeting our specifications, we decided to assume the burden of constructing our own system. As the system integrator, we embrace open architecture, thus enabling the incorporation of industry-standard-compliant, COTS (commercially off the shelf) products as modules. Microsoft Windows NT operating system, Visual C++ programming language, TCP/IP (transmission control protocol/internetworking protocol), relational SQL (structured query language) database, ODBC (open database connectivity), HL-7 (health level seven) and DICOM (digital imaging and communications in medicine) interfaces are utilized. The usage of COTS components reduces the cost to very affordable levels. With this approach, any module in our system can be replaced when outmoded, without affecting other modules in our system, making it truly future-proof. Construction and evolution of

  18. IAP/APA evidence-based guidelines for the management of acute pancreatitis.

    Science.gov (United States)

    2013-01-01

    There have been substantial improvements in the management of acute pancreatitis since the publication of the International Association of Pancreatology (IAP) treatment guidelines in 2002. A collaboration of the IAP and the American Pancreatic Association (APA) was undertaken to revise these guidelines using an evidence-based approach. Twelve multidisciplinary review groups performed systematic literature reviews to answer 38 predefined clinical questions. Recommendations were graded using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. The review groups presented their recommendations during the 2012 joint IAP/APA meeting. At this one-day, interactive conference, relevant remarks were voiced and overall agreement on each recommendation was quantified using plenary voting. The 38 recommendations covered 12 topics related to the clinical management of acute pancreatitis: A) diagnosis of acute pancreatitis and etiology, B) prognostication/predicting severity, C) imaging, D) fluid therapy, E) intensive care management, F) preventing infectious complications, G) nutritional support, H) biliary tract management, I) indications for intervention in necrotizing pancreatitis, J) timing of intervention in necrotizing pancreatitis, K) intervention strategies in necrotizing pancreatitis, and L) timing of cholecystectomy. Using the GRADE system, 21 of the 38 (55%) recommendations, were rated as 'strong' and plenary voting revealed 'strong agreement' for 34 (89%) recommendations. The 2012 IAP/APA guidelines provide recommendations concerning key aspects of medical and surgical management of acute pancreatitis based on the currently available evidence. These recommendations should serve as a reference standard for current management and guide future clinical research on acute pancreatitis. Copyright © 2013 IAP and EPC. Published by Elsevier B.V. All rights reserved.

  19. Research and teaching access to a large clinical picture archiving and communication system

    OpenAIRE

    Harrison, Marc; Koh, Justin; Tran, Steven; Mongkolwat, Patanasak; Channin, David S.

    2001-01-01

    Purpose: To identify practical issues surrounding delivering digital images from picture archiving and communication systems (PACS) for research and teaching purposes. The complexity of Digital Imaging and Communications in Medicine (DICOM) access methods, security, patient confidentiality, PACS database integrity, portability, and scalability are discussed. A software prototype designed to resolve these issues is described.System Architecture: A six-component, three-tier, client server softw...

  20. Nencki Affective Picture System: Cross-Cultural Study in Europe and Iran

    Science.gov (United States)

    Riegel, Monika; Moslehi, Abnoos; Michałowski, Jarosław M.; Żurawski, Łukasz; Horvat, Marko; Wypych, Marek; Jednoróg, Katarzyna; Marchewka, Artur

    2017-01-01

    Although emotions have been assumed conventionally to be universal, recent studies have suggested that various aspects of emotions may be mediated by cultural background. The purpose of our research was to test these contradictory views, in the case of the subjective evaluation of visual affective stimuli. We also sought to validate the recently introduced Nencki Affective Picture System (NAPS) database on a different cultural group. Since there has been, to date, no attempt to compare the emotions of a culturally distinct sample of Iranians with those of Europeans, subjective ratings were collected from 40 Iranians and 39 Europeans. Each cultural group was asked separately to provide normative affective ratings and classify pictures according to discrete emotions. The results were analyzed to identify cultural differences in the ratings of individual images. One hundred and seventy NAPS pictures were rated with regard to the intensity of the basic emotions (happiness, sadness, fear, surprise, anger, and disgust) they elicited, as well as in terms of affective dimensions (valence and arousal). Contrary to previous studies using the International Affective Picture System, our results for Europeans and Iranians show that neither the ratings for affective dimensions nor for basic emotions differed across cultural groups. In both cultural groups, the relationship between valence and arousal ratings could be best described by a classical boomerang-shaped function. However, the content of the pictures (animals, faces, landscapes, objects, or people) had a significant effect on the ratings for valence and arousal. These findings indicate that further studies in cross-cultural affective research should control for the content of stimuli. PMID:28316576

  1. Inhibition of Bcl-2 or IAP proteins does not provoke mutations in surviving cells

    Energy Technology Data Exchange (ETDEWEB)

    Shekhar, Tanmay M. [Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora 3083 (Australia); Green, Maja M. [Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora 3083 (Australia); Department of Anatomy & Neuroscience, The University of Melbourne, Parkville 3010 (Australia); Rayner, David M.; Miles, Mark A.; Cutts, Suzanne M. [Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora 3083 (Australia); Hawkins, Christine J., E-mail: c.hawkins@latrobe.edu.au [Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora 3083 (Australia)

    2015-07-15

    Graphical abstract: - Highlights: • Mutagenicities of anti-cancer drugs were tested using HPRT, γH2AX and comet assays. • TRAIL, doxorubicin and etoposide were more mutagenic than BH3- or Smac-mimetics. • Physiologically achievable levels of the BH3-mimetic ABT-737 were not mutagenic. • High concentrations of ABT-737 provoked mutations via an off-target mechanism. • Even very high concentrations of IAP antagonists were not mutagenic. - Abstract: Chemotherapy and radiotherapy can cause permanent damage to the genomes of surviving cells, provoking severe side effects such as second malignancies in some cancer survivors. Drugs that mimic the activity of death ligands, or antagonise pro-survival proteins of the Bcl-2 or IAP families have yielded encouraging results in animal experiments and early phase clinical trials. Because these agents directly engage apoptosis pathways, rather than damaging DNA to indirectly provoke tumour cell death, we reasoned that they may offer another important advantage over conventional therapies: minimisation or elimination of side effects such as second cancers that result from mutation of surviving normal cells. Disappointingly, however, we previously found that concentrations of death receptor agonists like TRAIL that would be present in vivo in clinical settings provoked DNA damage in surviving cells. In this study, we used cell line model systems to investigate the mutagenic capacity of drugs from two other classes of direct apoptosis-inducing agents: the BH3-mimetic ABT-737 and the IAP antagonists LCL161 and AT-406. Encouragingly, our data suggest that IAP antagonists possess negligible genotoxic activity. Doses of ABT-737 that were required to damage DNA stimulated Bax/Bak-independent signalling and exceeded concentrations detected in the plasma of animals treated with this drug. These findings provide hope that cancer patients treated by BH3-mimetics or IAP antagonists may avoid mutation-related illnesses that afflict

  2. Use of the Adult Attachment Projective Picture System in Psychodynamic Psychotherapy with a Severely Traumatized Patient

    Directory of Open Access Journals (Sweden)

    Carol eGeorge

    2014-08-01

    Full Text Available The Adult Attachment Projective Picture System (AAP is a valid representational measure of internal representations of attachment based on the analysis of a set of free response picture stimuli designed to systematically activate the attachment system (George & West, 2012. The AAP provides a fruitful diagnostic tool for psychodynamic-oriented clinicians to identify attachment-based deficits and resources for an individual patient in therapy. This paper considers the use of the AAP with a traumatized patient in an inpatient setting and uses a case study to illustrate the components of the AAP that are particularly relevant to a psychodynamic conceptualization. The paper discusses also attachment-based recommendations for intervention.

  3. Computed radiographic image post-processing for automatic optimal display in picture archiving and communication system

    Science.gov (United States)

    Zhang, Jianguo; Zhou, Zheng; Zhuang, Jun; Huang, H. K.

    2000-04-01

    This paper presents the key post-processing algorithms and their software implementing for CR image automatic optimal display in picture archiving and communication system, which compliant with DICOM model of the image acquisition and presentation chain. With the distributed implementation from the acquisition to the display, we achieved the effects of better image visual quality, fast image communication and display, as well as data integrity of archived CR images in PACS.

  4. Clinical integration of picture archiving and communication systems with pathology and hospital information system in oncology.

    Science.gov (United States)

    Duncan, Lisa D; Gray, Keith; Lewis, James M; Bell, John L; Bigge, Jeremy; McKinney, J Mark

    2010-09-01

    The complexity of our current healthcare delivery system has become an impediment to communication among caregivers resulting in fragmentation of patient care. To address these issues, many hospitals are implementing processes to facilitate clinical integration in an effort to improve patient care and safety. Clinical informatics, including image storage in a Picture Archiving and Communication System (PACS), represents a tool whereby clinical integration can be accomplished. In this study, we obtained intraoperative photographs of 19 cases to document clinical stage, extent of disease, disease recurrence, reconstruction/grafting, intraoperative findings not identified by preoperative imaging, and site verification as part of the Universal Protocol. Photographs from all cases were stored and viewed in PACS. Images from many of the cases were presented at our interdepartmental cancer conferences. The stored images improved communication among caregivers and preserved pertinent intraoperative findings in the patients' electronic medical record. In the future, pathology, gastroenterology, pulmonology, dermatology, and cardiology are just a few other subspecialties which could accomplish image storage in PACS. Multidisciplinary image storage in a PACS epitomizes the concept of clinical integration and its goal of improving patient care.

  5. Ubiquitination profiling identifies sensitivity factors for IAP antagonist treatment.

    Science.gov (United States)

    Varfolomeev, Eugene; Izrael-Tomasevic, Anita; Yu, Kebing; Bustos, Daisy; Goncharov, Tatiana; Belmont, Lisa D; Masselot, Alexandre; Bakalarski, Corey E; Kirkpatrick, Donald S; Vucic, Domagoj

    2015-02-15

    Evasion of cell death is one crucial capability acquired by tumour cells to ward-off anti-tumour therapies and represents a fundamental challenge to sustaining clinical efficacy for currently available agents. Inhibitor of apoptosis (IAP) proteins use their ubiquitin E3 ligase activity to promote cancer cell survival by mediating proliferative signalling and blocking cell death in response to diverse stimuli. Using immunoaffinity enrichment and MS, ubiquitination sites on thousands of proteins were profiled upon initiation of cell death by IAP antagonists in IAP antagonist-sensitive and -resistant breast cancer cell lines. Our analyses identified hundreds of proteins with elevated levels of ubiquitin-remnant [K-GG (Lys-Gly-Gly)] peptides upon activation of cell death by the IAP antagonist BV6. The majority of these were observed in BV6-sensitive, but not-resistant, cells. Among these were known pro-apoptotic regulators, including CYC (cytochrome c), RIP1 (receptor-interacting protein 1) and a selection of proteins known to reside in the mitochondria or regulate NF-κB (nuclear factor κB) signalling. Analysis of early time-points revealed that IAP antagonist treatment stimulated rapid ubiquitination of NF-κB signalling proteins, including TRAF2 [TNF (tumour necrosis factor) receptor-associated factor 2], HOIL-1 (haem-oxidized iron-regulatory protein 2 ubiquitin ligase-1), NEMO (NF-κB essential modifier), as well as c-IAP1 (cellular IAP1) auto-ubiquitination. Knockdown of several NF-κB pathway members reduced BV6-induced cell death and TNF production in sensitive cell lines. Importantly, RIP1 was found to be constitutively ubiquitinated in sensitive breast-cancer cell lines at higher basal level than in resistant cell lines. Together, these data show the diverse and temporally defined roles of protein ubiquitination following IAP-antagonist treatment and provide critical insights into predictive diagnostics that may enhance clinical efficacy.

  6. IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα

    Science.gov (United States)

    Shekhar, Tanmay M.; Miles, Mark A.; Gupte, Ankita; Taylor, Scott; Tascone, Brianna; Walkley, Carl R.; Hawkins, Christine J.

    2016-01-01

    Outcomes for patients diagnosed with the bone cancer osteosarcoma have not improved significantly in the last four decades. Only around 60% of patients and about a quarter of those with metastatic disease survive for more than five years. Although DNA-damaging chemotherapy drugs can be effective, they can provoke serious or fatal adverse effects including cardiotoxicity and therapy-related cancers. Better and safer treatments are therefore needed. We investigated the anti-osteosarcoma activity of IAP antagonists (also known as Smac mimetics) using cells from primary and metastatic osteosarcomas that arose spontaneously in mice engineered to lack p53 and Rb expression in osteoblast-derived cells. The IAP antagonists SM-164, GDC-0152 and LCL161, which efficiently target XIAP and cIAPs, sensitized cells from most osteosarcomas to killing by low levels of TNFα but not TRAIL. RIPK1 expression levels and activity correlated with sensitivity. RIPK3 levels varied considerably between tumors and RIPK3 was not required for IAP antagonism to sensitize osteosarcoma cells to TNFα. IAP antagonists, including SM-164, lacked mutagenic activity. These data suggest that drugs targeting XIAP and cIAP1/2 may be effective for osteosarcoma patients whose tumors express abundant RIPK1 and contain high levels of TNFα, and would be unlikely to provoke therapy-induced cancers in osteosarcoma survivors. PMID:27129149

  7. Inhibition of Reaper-induced apoptosis by interaction with inhibitor of apoptosis proteins (IAPs)

    OpenAIRE

    1997-01-01

    IAPs comprise a family of inhibitors of apoptosis found in viruses and animals. In vivo binding studies demonstrated that both baculovirus and Drosophila IAPs physically interact with an apoptosis-inducing protein of Drosophila, Reaper (RPR), through their baculovirus IAP repeat (BIR) region. Expression of IAPs blocked RPR-induced apoptosis and resulted in the accumulation of RPR in punctate perinuclear locations which coincided with IAP localization. When expressed alone, RPR rapidly disappe...

  8. IAP Guidelines on Rickettsial Diseases in Children.

    Science.gov (United States)

    Rathi, Narendra; Kulkarni, Atul; Yewale, Vijay

    2017-03-15

    To formulate practice guidelines on rickettsial diseases in children for pediatricians across India. Rickettsial diseases are increasingly being reported from various parts of India. Due to low index of suspicion, nonspecific clinical features in early course of disease, and absence of easily available, sensitive and specific diagnostic tests, these infections are difficult to diagnose. With timely diagnosis, therapy is easy, affordable and often successful. On the other hand, in endemic areas, where healthcare workers have high index of suspicion for these infections, there is rampant and irrational use of doxycycline as a therapeutic trial in patients of undifferentiated fevers. Thus, there is a need to formulate practice guidelines regarding rickettsial diseases in children in Indian context. A committee was formed for preparing guidelines on rickettsial diseases in children in June 2016. A meeting of consultative committee was held in IAP office, Mumbai and scientific content was discussed. Methodology and results were scrutinized by all members and consensus was reached. Textbook references and published guidelines were also used in few instances to make recommendations. Various Indian and international publications pertinent to present study were collated and guidelines were approved by all committee members. Future updates in these guidelines will be dictated by new scientific data in the field of rickettsial diseases in children. Indian tick typhus and scrub typhus are commonly seen rickettsial diseases in India. It is recommended that practicing pediatricians should be well conversant with compatible clinical scenario, suggestive epidemiological features, differential diagnoses and suggestive laboratory features to make diagnosis and avoid over diagnosis of these infections, as suggested in these guidelines. Doxycycline is the drug of choice and treatment should begin promptly without waiting for confirmatory laboratory results.

  9. Initial application of picture archiving and communication system and its benefit analysis

    Institute of Scientific and Technical Information of China (English)

    罗敏; 彭承琳; 王小林; 罗松; 雷文勇; 王康; 温洪宇; 王学健; 曹军

    2004-01-01

    In recent years, the daily clinical volume has increased rapidly to over 3000 patients in the Affiliated Hospital of Guiyang Medical College in southwestern China of Guizhou Province, and the pressure to improve working efficiency and scientific management has increased gradually. Previously, each imaging department and section did not liaise, so the archiving rate of image materials (film) is rather low. Damaged and missing films were a serious problem, adversely affecting the work of teaching, scientific research and clinics to a considerable extent. After establishing and applying a large-scale picture archiving and communication system (PACS), the administration of the hospital in these respects has been vastly improved.

  10. Picture archiving and communication systems (PACS) of dynamic image processing for cardiologic diagnostics of transportation workers

    Science.gov (United States)

    Gnedenko, Valeri G.; Ioseliani, D. G.; Nikiforov, S. N.; Fainberg, Evgeny M.

    2002-04-01

    Picture Archiving and Communication Systems (PACS) are the most perspective branch of medical technologies development. One of the most mass, cheap and effective methods of diagnostics and treatment of cardio-vascular diseases is interventional cardiology based on angiologic procedures. The principal difference of PACS for interventional cardiology is in necessity of gaining, analysis and archiving of dynamic images (angiology scenes). Russian Research Center > has developed and successfully implemented the first Russian PACS for interventional cardiology - complex for diagnostics, monitoring and treatment of cardio-vascular disease > which is described later in the article.

  11. [CORBA-based design and packaging of picture archiving and communication system object].

    Science.gov (United States)

    Zhang, Zu-jin; Sun, An-yu

    2009-10-01

    Regionalization has become one of the most important trends in the development of picture archiving and communication systems (PACS) due to the existence of large amounts of information islands. The conventional PACS designed according to the DICOM standard on the basis of the C/S structure fails to meet the demand of regional information system maintenance. A regional PACS system based on common object request broker architecture (CORBA) distributed technology is therefore proposed and implemented. This article describes the design and packaging of the PACS objects. When mounting a series of separate logical and related functional PACS objects on the ORB bus, the multi-scale PACS systems can be established. This method eliminates the limitation of the C/S structure and offers good compatibility and scalability.

  12. In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs).

    Science.gov (United States)

    Ohoka, Nobumichi; Okuhira, Keiichiro; Ito, Masahiro; Nagai, Katsunori; Shibata, Norihito; Hattori, Takayuki; Ujikawa, Osamu; Shimokawa, Kenichiro; Sano, Osamu; Koyama, Ryokichi; Fujita, Hisashi; Teratani, Mika; Matsumoto, Hirokazu; Imaeda, Yasuhiro; Nara, Hiroshi; Cho, Nobuo; Naito, Mikihiko

    2017-03-17

    Many diseases, especially cancers, result from aberrant or overexpression of pathogenic proteins. Specific inhibitors against these proteins have shown remarkable therapeutic effects, but these are limited mainly to enzymes. An alternative approach that may have utility in drug development relies on selective degradation of pathogenic proteins via small chimeric molecules linking an E3 ubiquitin ligase to the targeted protein for proteasomal degradation. To this end, we recently developed a protein knockdown system based on hybrid small molecule SNIPERs (Specific and Nongenetic IAP-dependent Protein Erasers) that recruit inhibitor of the apoptosis protein (IAP) ubiquitin ligases to specifically degrade targeted proteins. Here, we extend our previous study to show a proof of concept of the SNIPER technology in vivo By incorporating a high affinity IAP ligand, we developed a novel SNIPER against estrogen receptor α (ERα), SNIPER(ER)-87, that has a potent protein knockdown activity. The SNIPER(ER) reduced ERα levels in tumor xenografts and suppressed the growth of ERα-positive breast tumors in mice. Mechanistically, it preferentially recruits X-linked IAP (XIAP) rather than cellular IAP1, to degrade ERα via the ubiquitin-proteasome pathway. With this IAP ligand, potent SNIPERs against other pathogenic proteins, BCR-ABL, bromodomain-containing protein 4 (BRD4), and phosphodiesterase-4 (PDE4) could also be developed. These results indicate that forced ubiquitylation by SNIPERs is a useful method to achieve efficient protein knockdown with potential therapeutic activities and could also be applied to study the role of ubiquitylation in many cellular processes. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  13. Effects of picture exchange communication system on communication and behavioral anomalies in autism

    Directory of Open Access Journals (Sweden)

    Malhotra Shahzadi

    2010-01-01

    Full Text Available Communication skills deficits and stereotyped behaviors are frequently found among people with pervasive developmental disabilities like autism. These communication and behavioral oddities of autism are often considered to be difficult to treat and are challenging. Picture exchange communication system (PECS is a six-phase picture system based on applied behavior analysis and is specially designed to overcome these communication difficulties in children with autism by encouraging the child to be the communication initiator. The present paper throws light on the process of using PECS along with other traditional behavioral approaches in managing communication deficits and behavioral stereotypies in a seven-year-old male child diagnosed as having childhood autism. The identified target behaviors of repeated head turning, flapping his hands, poor communication skills were assessed using various rating scales including visual analogue scale as per clinician observation and parental reports and managed using PECS as an adjunct to traditional behavioral techniques of contingency management, differential reinforcement, task direction and reprimand. Outcome was assessed using same tools after thirty-two sessions of interventions spread over three months. Significant improvements of around 60% were observed in the target behaviors.

  14. Effects of Picture Exchange Communication System on Communication and Behavioral Anomalies in Autism

    Science.gov (United States)

    Malhotra, Shahzadi; Rajender, Gaurav; Bhatia, Manjeet S.; Singh, Tej B.

    2010-01-01

    Communication skills deficits and stereotyped behaviors are frequently found among people with pervasive developmental disabilities like autism. These communication and behavioral oddities of autism are often considered to be difficult to treat and are challenging. Picture exchange communication system (PECS) is a six-phase picture system based on applied behavior analysis and is specially designed to overcome these communication difficulties in children with autism by encouraging the child to be the communication initiator. The present paper throws light on the process of using PECS along with other traditional behavioral approaches in managing communication deficits and behavioral stereotypies in a seven-year-old male child diagnosed as having childhood autism. The identified target behaviors of repeated head turning, flapping his hands, poor communication skills were assessed using various rating scales including visual analogue scale as per clinician observation and parental reports and managed using PECS as an adjunct to traditional behavioral techniques of contingency management, differential reinforcement, task direction and reprimand. Outcome was assessed using same tools after thirty-two sessions of interventions spread over three months. Significant improvements of around 60% were observed in the target behaviors. PMID:21716776

  15. Development of a web-based picture archiving and communication system using satellite data communication.

    Science.gov (United States)

    Hwang, S; Lee, J; Kim, H; Lee, M

    2000-01-01

    Using the JAVA language we have developed a Web-based picture archiving and communication system (PACS) which allows a remote hospital to access medical images. An asymmetric satellite data communication system (ASDCS) provided a receive-only link for data delivery and a conventional terrestrial link (which could be the conventional telephone network) allowed data transmission. The satellite communication link was 10-30 times faster than the conventional terrestrial link. To increase image transmission speeds over the Internet connection, JPEG and wavelet compression methods were used. The resulting images were evaluated quantitatively by measuring the peak signal:noise ratio and qualitatively by radiologists. Compression ratios of 10:1 or less were deemed acceptable for diagnostic purposes. The system appears to be suitable for teleradiology and telemedicine.

  16. Cover Picture.

    Science.gov (United States)

    Breuning; Ruben; Lehn; Renz; Garcia; Ksenofontov; Gütlich; Wegelius; Rissanen

    2000-07-17

    The cover picture shows how both, fine arts and science, avail themselves of a system of intertwined symbolic and iconic languages. They make use of a common set of abstracted signs to report on their results. Thus, already in 1925, Wassily Kandinsky painted a masterpiece (bottom), which now, 75 years later, might be regarded as a blueprint for a scientific project. In his painting, Kandinsky pictured a grid-shaped sign that resembles in effect an actual molecular switch. Apparently following an enigmatic protocol, the groups of Lehn and Gütlich (see p. 2504 ff. for more details) constructed a grid-type inorganic architecture that operates as a three-level magnetic switch (center) triggered by three external perturbations (p, T, hnu). The switching principle is based on the spin-crossover phenomenon of Fe(II) ions and can be monitored by Mössbauer spectroscopy (left) and magnetic measurements (rear). Maybe not by chance, the English translation of the title of the painting "signs" is a homonym of "science", since both presented works are a product of the insatiable curiosity of man and his untiring desire to recognize his existence.

  17. Effects of affective picture viewing on postural control

    Directory of Open Access Journals (Sweden)

    Beek Peter J

    2007-10-01

    Full Text Available Abstract Background Emotion theory holds that unpleasant events prime withdrawal actions, whereas pleasant events prime approach actions. Recent studies have suggested that passive viewing of emotion eliciting images results in postural adjustments, which become manifest as changes in body center of pressure (COP trajectories. From those studies it appears that posture is modulated most when viewing pictures with negative valence. The present experiment was conducted to test the hypothesis that pictures with negative valence have a greater impact on postural control than neutral or positive ones. Thirty-four healthy subjects passively viewed a series of emotion eliciting images, while standing either in a bipedal or unipedal stance on a force plate. The images were adopted from the International Affective Picture System (IAPS. We analysed mean and variability of the COP and the length of the associated sway path as a function of emotion. Results The mean position of the COP was unaffected by emotion, but unipedal stance resulted in overall greater body sway than bipedal stance. We found a modest effect of emotion on COP: viewing pictures of mutilation resulted in a smaller sway path, but only in unipedal stance. We obtained valence and arousal ratings of the images with an independent sample of viewers. These subjects rated the unpleasant images as significantly less pleasant than neutral images, and the pleasant images as significantly more pleasant than neutral images. However, the subjects rated the images as overall less pleasant and less arousing than viewers in a closely comparable American study, pointing to unknown differences in viewer characteristics. Conclusion Overall, viewing emotion eliciting images had little effect on body sway. Our finding of a reduction in sway path length when viewing pictures of mutilation was indicative of a freezing strategy, i.e. fear bradycardia. The results are consistent with current knowledge about the

  18. Drosophila BRUCE inhibits apoptosis through non-lysine ubiquitination of the IAP-antagonist REAPER

    OpenAIRE

    Domingues, C.; Ryoo, H D

    2011-01-01

    Active caspases execute apoptosis to eliminate superfluous or harmful cells in animals. In Drosophila, living cells prevent uncontrolled caspase activation through an inhibitor of apoptosis protein (IAP) family member, dIAP1, and apoptosis is preceded by the expression of IAP-antagonists, such as Reaper, Hid and Grim. Strong genetic modifiers of this pathway include another IAP family gene encoding an E2 ubiquitin conjugating enzyme domain, dBruce. Although the genetic effects of dBruce mutan...

  19. Interest of including trauma photography in the picture archiving and communication system of a teaching hospital.

    Science.gov (United States)

    Bronsard, N; Chignon Sicard, B; Amoretti, N; Rottier, H; Ertz, P; de Peretti, F

    2015-05-01

    Digital imaging is a daily practice in traumatology. Such photographs should remain confidential. However, there is a need for objectivity concerning the circumstances and clinical follow-up for trauma patients. This paper describes how to conserve these photographs within the picture archiving and communication system (PACS) safely as regards identity and confidentiality. A computer converts the photographs into DICOM files. The DICOM image is associated to a reconciliation layer, validated by the physician in charge, and then included in the hospital PACS. This improves transmission from one medical team to another, both initially and after the accident if an expert medical opinion is required. The literature has demonstrated the value of photographs in modern medicine, but the technical and legal challenges are many. They enhance the computerized medical records. Identification, confidentiality and integration in the PACS are obstacles that we have now overcome. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  20. Some problems with picture archiving and communication system application in China

    Institute of Scientific and Technical Information of China (English)

    王涛; 高培毅

    2003-01-01

    @@ The hospital information system (HIS) of China has been developed continuously from single computer to the whole hospital information network in the past 20 years. Now, many hospitals have abandoned the hospital information management system (HMIS) that focuses on finance management, and reconstructed the clinical information system (CIS). The center of CIS is a workstation, where doctor will make orders and acquire clinic data of patients in anytime. Of course, the picture archiving and communication system (PACS) is an important portion of CIS. Through the interconnection between PACS and workstation, radiologists may acquire the basic information about patients from workstation, at the same time physicians will view medical images and diagnosis reports of these patients. By strict control of license permission, information of PACS may be shared in different degree by every physician. In radiology department, PACS is used for search reports, view images and also offer rich analysis and post-process function. PACS has become the hot topic of the radiology department construction in China. However, PACS in many hospitals has not yet brought our a significant benefit for radiology department and the whole hospital. Therefore, it is necessary to deal with these problems.

  1. A project plan for construction and cabling of picture archiving and communication system network

    Institute of Scientific and Technical Information of China (English)

    罗敏; 王小林; 罗松; 雷文勇; 王学健; 温洪宇; 吴红星

    2003-01-01

    Objective To determine a network solution to meet the network requirements of the heavy data flow, load balance, and potential network storms from expansion of picture archiving and communication system (PACS) application.Methods Intel Netstructure 480T Giga Switch was used as the main switch and connected to each building by fiber channel at 1 Giga speed to archive 100 MB/s to each port. At the same time, the in-dependence of the original network construction was physically kept. The layer 3 and 4 switchers were used as load balance to reduce the heavy load of the network, and all the cabling for PACS used the super CAT5 along with the Intel NetStructure 1520 to prepare for potential network storms.Results An advanced intranet was set up to fully meet the high standard requirement of the PACS. The foundation for upgrading the whole network system to 1 Giga application was built to achieve sharing and transmission of images, information, and patient data within the hospital. The base was established for the standardized management of the hospital.Conclusion Good planning is the first step in setting up PACS, and the equipment from the necessary platform to run PACS and all kinds of hospital information system (HIS). The networking construction is the foundation of e-hospital.

  2. Inhibitors of apoptosis (IAPs) regulate intestinal immunity and inflammatory bowel disease (IBD) inflammation

    DEFF Research Database (Denmark)

    Pedersen, Jannie; LaCasse, Eric C; Seidelin, Jakob B

    2014-01-01

    The inhibitor of apoptosis (IAP) family members, notably cIAP1, cIAP2, and XIAP, are critical and universal regulators of tumor necrosis factor (TNF) mediated survival, inflammatory, and death signaling pathways. Furthermore, IAPs mediate the signaling of nucleotide-binding oligomerization domain...... (NOD)1/NOD2 and other intracellular NOD-like receptors in response to bacterial pathogens. These pathways are important to the pathogenesis and treatment of inflammatory bowel disease (IBD). Inactivating mutations in the X-chromosome-linked IAP (XIAP) gene causes an immunodeficiency syndrome, X...

  3. Encoding Systems and Evolved Message Processing: Pictures Enable Action, Words Enable Thinking

    Directory of Open Access Journals (Sweden)

    Annie Lang

    2015-09-01

    Full Text Available This paper, based on theories of ecological perception, embodied motivated cognition, and evolutionary psychology, proposes that pictures elicit evolved biologically imperative responses more quickly and thoroughly than do words. These biologically imperative responses are directly responsible for evolved automatic reactions away from biological threats (e.g. escaping predators, avoiding disease and noxious stimuli and towards opportunities (e.g. consuming food, approaching mates, finding shelter in the environment. When elicited, these responses take time to occur and may delay or interfere with other types of behavior. Thus, when environmental information is presented in pictures (which should elicit larger biological responses than words biological responses should interfere more with higher order tasks like information processing and cognitive decision-making. To test this proposition we designed an experiment in which participants performed speeded categorizations of 60 pairs of matched pleasant and unpleasant environmental opportunities and threats. They categorized the items based on their form (is this a word or a picture? or based on how the picture made them feel (is this pleasant or unpleasant to you?. If pictures do elicit greater biologically imperative responses than their word counterparts, participants should be able to make form decisions faster than feeling decisions, especially when presented with words rather than pictures and especially when the words and pictures have less biological relevance. This main proposition was supported. Implications for this proposition in terms of communication theory are discussed.

  4. Multidimensional radar picture

    Science.gov (United States)

    Waz, Mariusz

    2010-05-01

    In marine navigation systems, the three-dimensional (3D) visualization is often and often used. Echosonders and sonars working in hydroacustic systems can present pictures in three dimensions. Currently, vector maps also offer 3D presentation. This presentation is used in aviation and underwater navigation. In the nearest future three-dimensional presentation may be obligatory presentation in displays of navigation systems. A part of these systems work with radar and communicates with it transmitting data in a digital form. 3D presentation of radar picture require a new technology to develop. In the first step it is necessary to compile digital form of radar signal. The modern navigation radar do not present data in three-dimensional form. Progress in technology of digital signal processing make it possible to create multidimensional radar pictures. For instance, the RSC (Radar Scan Converter) - digital radar picture recording and transforming tool can be used to create new picture online. Using RSC and techniques of modern computer graphics multidimensional radar pictures can be generated. The radar pictures mentioned should be readable for ECDIS. The paper presents a method for generating multidimensional radar picture from original signal coming from radar receiver.

  5. On the classification of emotional biosignals evoked while viewing affective pictures: an integrated data-mining-based approach for healthcare applications.

    Science.gov (United States)

    Frantzidis, Christos A; Bratsas, Charalampos; Klados, Manousos A; Konstantinidis, Evdokimos; Lithari, Chrysa D; Vivas, Ana B; Papadelis, Christos L; Kaldoudi, Eleni; Pappas, Costas; Bamidis, Panagiotis D

    2010-03-01

    Recent neuroscience findings demonstrate the fundamental role of emotion in the maintenance of physical and mental health. In the present study, a novel architecture is proposed for the robust discrimination of emotional physiological signals evoked upon viewing pictures selected from the International Affective Picture System (IAPS). Biosignals are multichannel recordings from both the central and the autonomic nervous systems. Following the bidirectional emotion theory model, IAPS pictures are rated along two dimensions, namely, their valence and arousal. Following this model, biosignals in this paper are initially differentiated according to their valence dimension by means of a data mining approach, which is the C4.5 decision tree algorithm. Then, the valence and the gender information serve as an input to a Mahalanobis distance classifier, which dissects the data into high and low arousing. Results are described in Extensible Markup Language (XML) format, thereby accounting for platform independency, easy interconnectivity, and information exchange. The average recognition (success) rate was 77.68% for the discrimination of four emotional states, differing both in their arousal and valence dimension. It is, therefore, envisaged that the proposed approach holds promise for the efficient discrimination of negative and positive emotions, and it is hereby discussed how future developments may be steered to serve for affective healthcare applications, such as the monitoring of the elderly or chronically ill people.

  6. Attentional bias to affective faces and complex IAPS images in early visual cortex follows emotional cue extraction.

    Science.gov (United States)

    Bekhtereva, Valeria; Craddock, Matt; Müller, Matthias M

    2015-05-15

    Emotionally arousing stimuli are known to rapidly draw the brain's processing resources, even when they are task-irrelevant. The steady-state visual evoked potential (SSVEP) response, a neural response to a flickering stimulus which effectively allows measurement of the processing resources devoted to that stimulus, has been used to examine this process of attentional shifting. Previous studies have used a task in which participants detected periods of coherent motion in flickering random dot kinematograms (RDKs) which generate an SSVEP, and found that task-irrelevant emotional stimuli withdraw more attentional resources from the task-relevant RDKs than task-irrelevant neutral stimuli. However, it is not clear whether the emotion-related differences in the SSVEP response are conditional on higher-level extraction of emotional cues as indexed by well-known event-related potential (ERPs) components (N170, early posterior negativity, EPN), or if affective bias in competition for visual attention resources is a consequence of a time-invariant shifting process. In the present study, we used two different types of emotional distractors - IAPS pictures and facial expressions - for which emotional cue extraction occurs at different speeds, being typically earlier for faces (at ~170ms, as indexed by the N170) than for IAPS images (~220-280ms, EPN). We found that emotional modulation of attentional resources as measured by the SSVEP occurred earlier for faces (around 180ms) than for IAPS pictures (around 550ms), after the extraction of emotional cues as indexed by visual ERP components. This is consistent with emotion related re-allocation of attentional resources occurring after emotional cue extraction rather than being linked to a time-fixed shifting process. Copyright © 2015 Elsevier Inc. All rights reserved.

  7. Study on user interface of pathology picture archiving and communication system.

    Science.gov (United States)

    Kim, Dasueran; Kang, Peter; Yun, Jungmin; Park, Sung-Hye; Seo, Jeong-Wook; Park, Peom

    2014-01-01

    It is necessary to improve the pathology workflow. A workflow task analysis was performed using a pathology picture archiving and communication system (pathology PACS) in order to propose a user interface for the Pathology PACS considering user experience. An interface analysis of the Pathology PACS in Seoul National University Hospital and a task analysis of the pathology workflow were performed by observing recorded video. Based on obtained results, a user interface for the Pathology PACS was proposed. Hierarchical task analysis of Pathology PACS was classified into 17 tasks including 1) pre-operation, 2) text, 3) images, 4) medical record viewer, 5) screen transition, 6) pathology identification number input, 7) admission date input, 8) diagnosis doctor, 9) diagnosis code, 10) diagnosis, 11) pathology identification number check box, 12) presence or absence of images, 13) search, 14) clear, 15) Excel save, 16) search results, and 17) re-search. And frequently used menu items were identified and schematized. A user interface for the Pathology PACS considering user experience could be proposed as a preliminary step, and this study may contribute to the development of medical information systems based on user experience and usability.

  8. "Permanent" records: experience with data migration in radiology information system and picture archiving and communication system replacement.

    Science.gov (United States)

    Behlen, F M; Sayre, R E; Weldy, J B; Michael, J S

    2000-05-01

    In the replacement of both a radiology information system (RIS) and a picture archiving and communication system (PACS) archive, data were migrated from the prior system to the new system. We report on the process, the time and resources required, and the fidelity of data transfer. We find that for two PACS archives, both organized according to the Digital Imaging and Communications in Medicine (DICOM) information model, data may be transferred with full fidelity, but the time required for transfer is significant. Transfer from off-line backup media was found to be faster than transfer from our robotic tape library. In contrast, the RIS replacement required extensive labor to translate prior data between dissimilar information models, and some data were inevitably lost in the translation. Standards for RIS information models are needed to promote the migration of data without loss of content.

  9. Prototype development and implementation of picture archiving and communications systems based on ISO-OSI standard

    Science.gov (United States)

    Martinez, Ralph; Nam, Jiseung

    1992-07-01

    Picture Archiving and Communication Systems (PACS) is an integration of digital image formation in a hospital, which encompasses various imaging equipment, image viewing workstations, image databases, and a high speed network. The integration requires a standardization of communication protocols to connect devices from different vendors. The American College of Radiology and the National Electrical Manufacturers Association (ACR- NEMA) standard Version 2.0 provides a point-to-point hardware interface, a set of software commands, and a consistent set of data formats for PACS. But, it is inadequate for PACS networking environments, because of its point-to-point nature and its inflexibility to allow other services and protocols in the future. Based on previous experience of PACS developments in The University of Arizona, a new communication protocol for PACS networks and an approach were proposed to ACR-NEMA Working Group VI. The defined PACS protocol is intended to facilitate the development of PACS''s capable of interfacing with other hospital information systems. Also, it is intended to allow the creation of diagnostic information data bases which can be interrogated by a variety of distributed devices. A particularly important goal is to support communications in a multivendor environment. The new protocol specifications are defined primarily as a combination of the International Organization for Standardization/Open Systems Interconnection (ISO/OSI), TCP/IP protocols, and the data format portion of ACR-NEMA standard. This paper addresses the specification and implementation of the ISO-based protocol into a PACS prototype. The protocol specification, which covers Presentation, Session, Transport, and Network layers, is summarized briefly. The protocol implementation is discussed based on our implementation efforts in the UNIX Operating System Environment. At the same time, results of performance comparison between the ISO and TCP/IP implementations are presented

  10. Designing fault-tolerant distributed archives for picture archiving and communication systems.

    Science.gov (United States)

    Mendenhall, R; Dewey, M; Soutar, I

    2001-06-01

    Distributed archives in a picture archiving and communication system (PACS) environment can provide added fault tolerance and fail-over capability, as well as increased load capacity at a more economical price than traditional 'high-availability" systems. Systems can be configured with varying levels of fault tolerance, depending on the amount of redundancy desired. There is, however, a direct correlation between the level of hardware redundancy and cost to implement. This presentation details the system design for fault-tolerant distributed archives as well as several options for redundancy, referencing implementation of a fault-tolerant archive system at the University of Utah. The distributed archive system described here is based on Image Devices' image archive software, which can be implemented on multiple individual archive servers in order to distribute archive functionality and operational load. The configuration and implementation of the individual servers together make up the distributed archive system and does not impact the ability of the system to be scaled to meet future requirements. Several implementation and configuration options exist, including the ability for servers to maintain replicated databases containing patient and image information. Thus, each archive can be aware of all information and the location of this information within the distributed archive system. The goal is to produce systems that will still be operational in the event of any single point of failure, ie, a network connection failure between facilities or the failure of a single archive server within the distributed system. During normal operation, workload for image acquisition, image routing and image query requests will be distributed between the archive servers. If the system is deployed in a multifacility environment, each archive server can be configured to be responsible for the acquisition and image distribution management within that server's local facility. If the

  11. Planning factors for developing an enterprise-wide picture archiving and communication system maintenance program.

    Science.gov (United States)

    Staley, S; Romlein, J; Chacko, A K; Wider, R

    2000-05-01

    Picture archiving and communication system (PACS) maintenance on an individual site basis has historically been a complex and costly challenge. With the advent of enterprise-wide PACS projects such as the Virtual Radiology Environment (VRE) project, the challenge of a maintenance program with even more complexities has presented itself. The approach of the project management team for the VRE project is not one of reactive maintenance, but one of highly proactive planning and negotiations, in hopes of capitalizing on the economies of scale of an enterprise-wide PACS maintenance program. A proactive maintenance program is one aspect of life-cycle management. As with any capital acquisition, life-cycle management may be used to manage the specific project aspects related to PACS. The purpose of an enterprise-wide warranty and maintenance life-cycle management approach is to maintain PACS at its maximum operational efficiency and utilization levels through a flexible, shared, yet symbiotic relationship between local, regional, and vendor resources. These goals include providing maximum operational performance levels on a local, regional, and enterprise basis, while maintaining acceptable costs and resource utilization levels. This goal must be achieved without negatively impacting point of care activities, regardless of changes to the clinical business environment.

  12. Non-Fermi liquid picture and superconductivity in heavy fermion systems

    Energy Technology Data Exchange (ETDEWEB)

    Sykora, Steffen [IFW Dresden, D- 01171 Dresden (Germany); Becker, Klaus W. [Department of Physics, TU Dresden, D-01069 Dresden (Germany)

    2013-07-01

    We study the S = 1/2 Kondo lattice model which is widely used to describe heavy fermion behavior. In conventional treatments of the model a hybridization of conduction and localized f electrons is introduced by decoupling the Kondo interaction. However, such an approximation has the detrimental effect that a breaking of a local gauge symmetry is imposed which implicates that the local f occupation n{sub i}{sup f} is no longer conserved. To avoid such an artifact, we treat the model in an alternative approach based on the Projective Renormalization Method (PRM). Thereby, within the conduction electron spectral function we identify the lattice Kondo resonance as an almost flat incoherent excitation near the Fermi surface which is composed of conduction electron creation operators combined with localized spin fluctuations. This leads to a new concept of the Kondo resonance without having to resort to a symmetry breaking and Fermi liquid theory. Based on this new picture we develop a microscopic theory for superconductivity in heavy fermion systems. Thereby we study the momentum-dependence of the superconducting order parameter for singlet as well as triplet pairing. We show that in particular the triplet pairing components are strongly affected by the incoherent excitations found to be responsible for the Kondo resonance.

  13. Experience measuring performance improvement in multiphase picture archiving and communications systems implementations.

    Science.gov (United States)

    Reed, G; Reed, D H

    1999-05-01

    When planning a picture archiving and communications system (PACS) implementation and determining which equipment will be implemented in earlier and later phases, collection and analysis of selected data will aid in setting implementation priorities. If baseline data are acquired relative to performance objectives, the same information used for implementation planning can be used to measure performance improvement and outcomes. The main categories of data to choose from are: (1) financial data; (2) productivity data; (3) operational parameters; (4) clinical data; and (5) information about customer satisfaction. In the authors' experience, detailed workflow data have not proved valuable in measuring PACS performance and outcomes. Reviewing only one category of data in planning will not provide adequate basis for targeting operational improvements that will lead to the most significant gains. Quality improvement takes into account all factors in production: human capacity, materials, operating capital and assets. Once we have identified key areas of focus for quality improvement in each phase, we can translate objectives into implementation requirements and finally into detailed functional and performance requirements. Here, Integration Resources reports its experience measuring PACS performance relative to phased implementation strategies for three large medical centers. Each medical center had its own objectives for overcoming image management, physical/geographical, and functional/technical barriers. The report outlines (1) principal financial and nonfinancial measures used as performance indicators; (2) implementation strategies chosen by each of the three medical centers; and (3) the results of those strategies as compared with baseline data.

  14. Prospect: A Picture Exchange Communication System (PECS)-based Instant Messaging Application for Autism Spectrum Condition

    Science.gov (United States)

    Raja, Pravind; Zainuri Saringat, Mohd; Mustapha, Aida; Zainal, Abidah

    2017-08-01

    Autism Spectrum Disorder (ASC) has widely gained the common attention from the public especially autistic communities. Individuals with ASC are said to have poor verbal skills and this affects them in carrying out their daily basis which they are afraid to expose themselves to the world due to their problems. ASC is diagnosed among children ranging from ages 5-12 years old and they suffer from the abnormal functioning of the brain which in turn causes lack of development activities. Thus, studies have shown that diagrammatic approaches help children with ASC to overcome their issues and improvise their visual and verbal skills. Picture Exchange Communication System or PECS consists of a series of illustrated cards and each cards has its own illustration with a caption on it. These children will understand the cards and they can compile several other cards to form sentences. This paper presents a mobile application called the Prospect, which has been developed using the agile development model for digital representation of PECS. The application is hoped to enhance the learning process and a better yielding results.

  15. Image fusion using MIM software via picture archiving and communication system

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The preliminary studies of the multimodality image registration andfusion were performed using an image fusion software and a picture archiving andcommunication system (PACS) to explore the methodology. Original image voluminaldata were acquired with a CT scanner, MR and dual-head coincidence SPECT, respec-tively. The data sets from all imaging devices were queried, retrieved, transferred andaccessed via DICOM PACS. The image fusion was performed at thc SPECT ICONwork-station, where the MIM (Medical Image Merge) fusion software was installed.The images were created by reslicing original volume on the fly. The image volumeswere aligned by translation and rotation of these view ports with respect to the origi-nal volume orientation. The transparency factor and contrast were adjusted in orderthat both volumes can be visualized in the merged images. The image volume data ofCT, MR and nuclear medicine were transferred, accessed and loaded via PACS suc-cessfully. The perfect fused images of chest CT/18F-FDG and brain MR/SPECT wereobtained. These results showed that image fusion technique using PACS was feasibleand practical. Further experimentation and larger validation studies were needed toexplore the full potential of the clinical use.

  16. Process reengineering: the role of a planning methodology and picture archiving and communications system team building.

    Science.gov (United States)

    Carrino, J A; Unkel, P J; Shelton, P; Johnson, T G

    1999-05-01

    The acquisition of a picture archiving and communications system (PACS) is an opportunity to reengineer business practices and should optimally consider the entire process from image acquisition to communication of results. The purpose of this presentation is to describe the PACS planning methodology used by the Department of Defense (DOD) Joint Imaging Technology Project Office (JITPO), outline the critical procedures for each phase, and review the military experience using this model. The methodology is segmented into four phases: strategic planning, clinical scenario planning, installation planning, and implementation planning. Each is further subdivided based on the specific tasks that need to be accomplished within that phase. By using this method, an institution will have clearly defined program goals, objectives, and PACS requirements before vendors are contacted. The development of an institution-specific PACS requirement should direct the process of proposal comparisons to be based on functionality and exclude unnecessary equipment. This PACS planning methodology is being used at more than eight DOD medical treatment facilities. When properly executed, this methodology facilitates a seamless transition to the electronic environment and contributes to the successful integration of the healthcare enterprise. A crucial component of this methodology is the development of a local PACS planning team to manage all aspects of the process. A plan formulated by the local team is based on input from each department that will be integrating with the PACS. Involving all users in the planning process is paramount for successful implementation.

  17. Assessing Attachment Representations in Adolescents: Discriminant Validation of the Adult Attachment Projective Picture System.

    Science.gov (United States)

    Gander, Manuela; George, Carol; Pokorny, Dan; Buchheim, Anna

    2017-04-01

    The contribution of attachment to human development and clinical risk is well established for children and adults, yet there is relatively limited knowledge about attachment in adolescence due to the poor availability of construct valid measures. The Adult Attachment Projective Picture System (AAP) is a reliable and valid instrument to assess adult attachment status. This study examines for the first time the discriminant validity of the AAP in adolescents. In our sample of 79 teenagers between 15 and 18 years, 42 % were classified as secure, 34 % as insecure-dismissing, 13 % as insecure-preoccupied and 11 % as unresolved. The results demonstrated discriminant validity for using the AAP in that age group, with no associations between attachment classifications and verbal intelligence, social desirability, story length or sociodemographic variables. These results poise the AAP to be used in clinical intervention and large-scale research investigating normative and atypical developmental correlates and sequelae of attachment, including psychopathology in adolescence.

  18. Teaching Children with Autism to Engage in Peer-Directed Mands Using a Picture Exchange Communication System

    Science.gov (United States)

    Paden, Amber R.; Kodak, Tiffany; Fisher, Wayne W.; Gawley-Bullington, Elizabeth M.; Bouxsein, Kelly J.

    2012-01-01

    We evaluated differential reinforcement of alternative behavior (DRA) plus prompting to increase peer-directed mands for preferred items using a picture exchange communication system (PECS). Two nonvocal individuals with autism participated. Independent mands with a peer increased with the implementation of DRA plus prompting for both…

  19. Comparative Efficacy of the Picture Exchange Communication System (PECS) versus a Speech-Generating Device: Effects on Requesting Skills

    Science.gov (United States)

    Boesch, Miriam C.; Wendt, Oliver; Subramanian, Anu; Hsu, Ning

    2013-01-01

    An experimental, single-subject research study investigated the comparative efficacy of the Picture Exchange Communication System (PECS) versus a speech-generating device (SGD) in developing requesting skills for three elementary-age children with severe autism and little to no functional speech. Results demonstrated increases in requesting…

  20. Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome.

    Science.gov (United States)

    Labbé, Katherine; McIntire, Christian R; Doiron, Karine; Leblanc, Philippe M; Saleh, Maya

    2011-12-23

    Pathogen and danger recognition by the inflammasome activates inflammatory caspases that mediate inflammation and cell death. The cellular inhibitor of apoptosis proteins (cIAPs) function in apoptosis and innate immunity, but their role in modulating the inflammasome and the inflammatory caspases is unknown. Here we report that the cIAPs are critical effectors of the inflammasome and are required for efficient caspase-1 activation. cIAP1, cIAP2, and the adaptor protein TRAF2 interacted with caspase-1-containing complexes and mediated the activating nondegradative K63-linked polyubiquitination of caspase-1. Deficiency in cIAP1 (encoded by Birc2) or cIAP2 (Birc3) impaired caspase-1 activation after spontaneous or agonist-induced inflammasome assembly, and Birc2(-/-) or Birc3(-/-) mice or mice administered with an IAP antagonist had a dampened response to inflammasome agonists and were resistant to peritonitis. Our results describe a role for the cIAPs in innate immunity and further demonstrate the evolutionary conservation between cell death and inflammation mechanisms.

  1. OTUB1 modulates c-IAP1 stability to regulate signalling pathways.

    Science.gov (United States)

    Goncharov, Tatiana; Niessen, Kyle; de Almagro, Maria Cristina; Izrael-Tomasevic, Anita; Fedorova, Anna V; Varfolomeev, Eugene; Arnott, David; Deshayes, Kurt; Kirkpatrick, Donald S; Vucic, Domagoj

    2013-04-17

    The cellular inhibitor of apoptosis (c-IAP) proteins are E3 ubiquitin ligases that are critical regulators of tumour necrosis factor (TNF) receptor (TNFR)-mediated signalling. Through their E3 ligase activity c-IAP proteins promote ubiquitination of receptor-interaction protein 1 (RIP1), NF-κB-inducing kinase (NIK) and themselves, and regulate the assembly of TNFR signalling complexes. Consequently, in the absence of c-IAP proteins, TNFR-mediated activation of NF-κB and MAPK pathways and the induction of gene expression are severely reduced. Here, we describe the identification of OTUB1 as a c-IAP-associated deubiquitinating enzyme that regulates c-IAP1 stability. OTUB1 disassembles K48-linked polyubiquitin chains from c-IAP1 in vitro and in vivo within the TWEAK receptor-signalling complex. Downregulation of OTUB1 promotes TWEAK- and IAP antagonist-stimulated caspase activation and cell death, and enhances c-IAP1 degradation. Furthermore, knockdown of OTUB1 reduces TWEAK-induced activation of canonical NF-κB and MAPK signalling pathways and modulates TWEAK-induced gene expression. Finally, suppression of OTUB1 expression in zebrafish destabilizes c-IAP (Birc2) protein levels and disrupts fish vasculature. These results suggest that OTUB1 regulates NF-κB and MAPK signalling pathways and TNF-dependent cell death by modulating c-IAP1 stability.

  2. Electronic teaching files: seven-year experience using a commercial picture archiving and communication system.

    Science.gov (United States)

    Siegel, E; Reiner, B

    2001-06-01

    With the advent of electronic imaging and the internet, the ability to create, search, access, and archive digital imaging teaching files has dramatically improved. Despite the fact that a picture archival and communication system (PACS) has the potential to greatly simplify the creation of, archival, and access to a department or multifacility teaching file, this potential has not yet been satisfactorily realized in our own and most other PACS installations. Several limitations of the teaching file tools within our PACS have become apparent over time. These have, at our facility, resulted in a substantially reduced role of the teaching file tools for conferences, daily teaching, and research purposes. With the PACS at our institution, academic folders can only be created by the systems engineer, which often serves as an impediment to the teaching process. Once these folders are created, multiple steps are required to identify the appropriate folders, and subsequently save images. Difficulties exist for those attempting to search for the teaching file images. Without pre-existing knowledge of the folder name and contents, it is difficult to query the system for specific images. This is due to the fact that there is currently no fully satisfactory mechanism for categorizing, indexing, and searching cases using the PACS. There is currently no easy mechanism to save teaching, research, or clinical files onto a CD or other removable media or to automatically strip demographic or other patient information from the images. PACS vendors should provide much more sophisticated tools to create and annotate teaching file images in an easy to use but standard format (possibly Radiological Society of North America's Medical Image Resource Center [MIRC] format) that could be exchanged with other sites and other vendors' PAC systems. The privilege to create teaching or conference files should be given to the individual radiologists, technologists, and other users, and an audit

  3. Erotic subset for the Nencki Affective Picture System (NAPS ERO: cross-sexual comparison study

    Directory of Open Access Journals (Sweden)

    Małgorzata eWierzba

    2015-09-01

    Full Text Available Research on the processing of sexual stimuli has proved that such material has high priority in human cognition. Yet, although sex differences in response to sexual stimuli were extensively discussed in the literature, sexual orientation was given relatively little consideration, and material suitable for relevant research is difficult to come by. With this in mind, we present a collection of 200 erotic images, accompanied by their self-report ratings of emotional valence and arousal by homo- and heterosexual males and females (n = 80, divided into four equal-sized subsamples. The collection complements the Nencki Affective Picture System (NAPS and is intended to be used as stimulus material in experimental research. The erotic images are divided into five categories, depending on their content: opposite-sex couple (50, male couple (50, female couple (50, male (25 and female (25. Additional 100 control images from the NAPS depicting people in a non-erotic context were also used in the study. We showed that recipient sex and sexual orientation strongly influenced the evaluation of erotic content. Thus, comparisons of valence and arousal ratings in different subject groups will help researchers select stimuli set for the purpose of various experimental designs. To facilitate the use of the dataset, we provide an on-line tool, which allows the user to browse the images interactively and select proper stimuli on the basis of several parameters. The NAPS ERO image collection together with the data are available to the scientific community for non-commercial use at http://naps.nencki.gov.pl.

  4. Erotic subset for the Nencki Affective Picture System (NAPS ERO): cross-sexual comparison study.

    Science.gov (United States)

    Wierzba, Małgorzata; Riegel, Monika; Pucz, Anna; Leśniewska, Zuzanna; Dragan, Wojciech Ł; Gola, Mateusz; Jednoróg, Katarzyna; Marchewka, Artur

    2015-01-01

    Research on the processing of sexual stimuli has proved that such material has high priority in human cognition. Yet, although sex differences in response to sexual stimuli were extensively discussed in the literature, sexual orientation was given relatively little consideration, and material suitable for relevant research is difficult to come by. With this in mind, we present a collection of 200 erotic images, accompanied by their self-report ratings of emotional valence and arousal by homo- and heterosexual males and females (n = 80, divided into four equal-sized subsamples). The collection complements the Nencki Affective Picture System (NAPS) and is intended to be used as stimulus material in experimental research. The erotic images are divided into five categories, depending on their content: opposite-sex couple (50), male couple (50), female couple (50), male (25) and female (25). Additional 100 control images from the NAPS depicting people in a non-erotic context were also used in the study. We showed that recipient sex and sexual orientation strongly influenced the evaluation of erotic content. Thus, comparisons of valence and arousal ratings in different subject groups will help researchers select stimuli set for the purpose of various experimental designs. To facilitate the use of the dataset, we provide an on-line tool, which allows the user to browse the images interactively and select proper stimuli on the basis of several parameters. The NAPS ERO image collection together with the data are available to the scientific community for non-commercial use at http://naps.nencki.gov.pl.

  5. Effects of the Adult Attachment Projective Picture System on Oxytocin and Cortisol Blood Levels in Mothers

    Science.gov (United States)

    Krause, Sabrina; Pokorny, Dan; Schury, Katharina; Doyen-Waldecker, Cornelia; Hulbert, Anna-Lena; Karabatsiakis, Alexander; Kolassa, Iris-Tatjana; Gündel, Harald; Waller, Christiane; Buchheim, Anna

    2016-01-01

    Oxytocin, a small neuropeptide of nine amino acids, has been characterized as the “hormone of affiliation” and is stimulated, for instance, in mothers when interacting with their offspring. Variations in maternal oxytocin levels were reported to predict differences in the quality of care provided by mothers. In this study, the Adult Attachment Projective Picture System (AAP) as a valid measure to assess attachment representations was used as an activating attachment-related stimulus. We investigated whether the AAP induces a release of oxytocin in mothers with a secure attachment representation and a stress-related cortisol response in mothers with an insecure attachment representation. Therefore, pre-post effects of AAP administration on plasma oxytocin and serum cortisol levels were investigated in n = 44 mothers 3 months after parturition. Oxytocin levels increased from pre to post in the significant majority of 73% participants (p = 0.004) and cortisol decreased in the significant majority of 73% participants (p = 0.004). Interestingly, no association between alterations in oxytocin and cortisol were found; this suggests taking a model of two independent processes into considerations. These results show that the AAP test procedure induces an oxytocin response. Concerning the results within the four AAP representation subgroups, our hypothesis of a particularly strong increase in oxytocin in secure mothers was not confirmed; however, in secure mothers we observed a particularly strong decrease in cortisol. Effect sizes are reported, allowing the replication of results in a larger study with sufficient sample size to draw final conclusions with respect to differences in OT and cortisol alterations depending on attachment representation. When interpreting the results, one should keep in mind that this study investigated lactating mothers. Thus, the generalizability of results is limited and future studies should investigate non-lactating healthy females as

  6. Effects of the Adult Attachment Projective Picture System on oxytocin and cortisol blood levels in mothers

    Directory of Open Access Journals (Sweden)

    Sabrina Krause

    2016-12-01

    Full Text Available Oxytocin, a small neuropeptide of nine amino acids, has been characterized as the hormone of affiliation and is stimulated, for instance, in mothers when interacting with their offspring. Variations in maternal oxytocin levels were reported to predict differences in the quality of care provided by mothers. In this study, the Adult Attachment Projective Picture System (AAP as a valid measure to assess attachment representations was used as an activating attachment-related stimulus. We investigated whether the AAP induces a release of oxytocin in mothers with a secure attachment representation and a stress-related cortisol response in mothers with an insecure attachment representation. Therefore, pre-post effects of AAP administration on plasma oxytocin and serum cortisol levels were investigated in n = 44 mothers 3 months after parturition. Oxytocin levels increased from pre to post by the significant majority of 73% participants (p = .004 and cortisol decreased by the significant majority of 73% participants (p = .004. Interestingly, no association between alterations in oxytocin and cortisol were found; this suggests taking a model of two independent processes into considerations. These results show that the AAP test procedure induces an oxytocin response. Concerning the results within the four AAP representation subgroups, our hypothesis of a particularly strong increase in oxytocin in secure mothers was not confirmed; however, in secure mothers we observed a particularly strong decrease in cortisol, consistent with our hypotheses. Effect sizes are reported, allowing the replication of results in a larger study with sufficient sample size to draw final conclusions with respect to differences in OT and cortisol alterations depending on attachment representation. When interpreting the results, one should keep in mind that this study investigated lactating mothers. Thus, the generalizability of results is limited and future studies should

  7. Picture perfect

    DEFF Research Database (Denmark)

    Pless, Mette; Sørensen, Niels Ulrik

    Picture perfect’ – when perfection becomes the new normal This paper draws on perspectives from three different studies. One study, which focuses on youth life and lack of well-being (Sørensen et al 2011), one study on youth life on the margins of society (Katznelson et al 2015) and one study on...

  8. The filmless radiology reading room: a survey of established picture archiving and communication system sites.

    Science.gov (United States)

    Siegel, E; Reiner, B; Abiri, M; Chacko, A; Morin, R; Ro, D W; Spicer, K; Strickland, N; Young, J

    2000-05-01

    The purpose of this study was to survey radiologists experienced in soft-copy diagnosis using computer workstations about their current reading room environment, their impressions of the efficacy of their reading room design, and their recommendations based on their experience for improvement of the soft-copy reading environment. Surveys were obtained from radiologists at seven sites representing three major picture archiving and communication system (PACS) vendors throughout the world that have had extensive experience with soft-copy interpretation of radiology studies. The radiologists filled out a detailed survey, which was designed to assess their current reading room environment and to provide them with the opportunity to make suggestions about improvement of the PACS reading rooms. The survey data were entered into a database and results were correlated with multiple parameters, including experience with PACS, types of modalities interpreted on the system, and number of years of experience in radiology. The factors judged to be most important in promoting radiologist productivity were room lighting, monitor number, and monitor brightness. Almost all of the radiologists indicated that their lighting source was from overhead rather than indirect or portable light sources. Approximately half indicated they had the capability of dimming the brightness of the overhead lighting. Most radiologists indicated that they were able to adjust room temperature but that they did not have individual temperature controls at their workstations. The radiologists indicated that the most troublesome sources of noise included background noise, other radiologists, and clinicians much more than noise from computer monitors, technologists, or patients. Most radiologists did not have chairs that could recline or arm rests. Most did have wheels and the capability to swivel, both of which were judged important. The majority of chairs also had lumbar support, which was also seen to be

  9. PEOPLE RETRIEVAL BY MEANS OF COMPOSITE PICTURES: METHODS, SYSTEMS AND PRACTICAL DECISIONS

    Directory of Open Access Journals (Sweden)

    G. A. Kukharev

    2015-07-01

    Full Text Available We discuss the problem of people retrieval by means of composite pictures and methods of its practical realization. Earlier on, the problem was posed in the previous paper by the authors, and this paper deals with its further development. The starting premise here is that for the successful search of people by their sketches it is necessary to transform these sketches into sets of populations of sketches imitating evidence of «group of witnesses» and evidence with incomplete information in verbal portraits. Variants of structures for benchmark «photo-sketch» databases are presented, intended for modeling and practical realization of original photos retrieval by sketches, which new component is a population of sketches. Problems of preprocessing for initial sketches and original photos and its influence on the result of their comparison are discussed. Simple sketch recognition systems (Simple FaRetSys and a problem of original photos retrieval by the sketches are considered. Shortcomings of such systems are shown and new decisions on extending and development of simple systems (Extended FaRetSys are presented. Experiments on searching of original photos by sketches in the CUFS database of sketches and similar experiments on widely known FERET and CUFSF facial databases are presented. Three frameworks are offered for retrieval performance improvement. In the first one, original sketches are transformed into populations, and then in these populations the sketch similar to the given sketch (Forensic Sketch is already defined. The class of the sketch found in a population «by definition» unambiguously corresponds to a class of the original photo. In the second framework, the Forensic Sketch is transformed to a population of sketches, and all original sketches in a benchmarking database are compared to sketches from populations of the Forensic Sketch. The class of matches is determined in the same manner as in the first framework. The third

  10. The amodal system for conscious word and picture identification in the absence of a semantic task

    NARCIS (Netherlands)

    Doren, L. Van; Dupont, P.; Grauwe, S.M.T. De; Peeters, R.; Vandenberghe, R.

    2010-01-01

    Previous studies using explicit semantic tasks, such as category or similarity judgments, have revealed considerable neuroanatomical overlap between processing of the meaning of words and pictures. This result may have been influenced by the semantic executive control required by such tasks. We exam

  11. Inhibitors of apoptosis (IAPs) regulate intestinal immunity and inflammatory bowel disease (IBD) inflammation.

    Science.gov (United States)

    Pedersen, Jannie; LaCasse, Eric C; Seidelin, Jakob B; Coskun, Mehmet; Nielsen, Ole H

    2014-11-01

    The inhibitor of apoptosis (IAP) family members, notably cIAP1, cIAP2, and XIAP, are critical and universal regulators of tumor necrosis factor (TNF) mediated survival, inflammatory, and death signaling pathways. Furthermore, IAPs mediate the signaling of nucleotide-binding oligomerization domain (NOD)1/NOD2 and other intracellular NOD-like receptors in response to bacterial pathogens. These pathways are important to the pathogenesis and treatment of inflammatory bowel disease (IBD). Inactivating mutations in the X-chromosome-linked IAP (XIAP) gene causes an immunodeficiency syndrome, X-linked lymphoproliferative disease type 2 (XLP2), in which 20% of patients develop severe intestinal inflammation. In addition, 4% of males with early-onset IBD also have inactivating mutations in XIAP. Therefore, the IAPs play a greater role in gut homeostasis, immunity and IBD development than previously suspected, and may have therapeutic potential.

  12. Inhibitor of Apoptosis (IAP proteins in pediatric leukemia: Molecular pathways and novel approaches to therapy

    Directory of Open Access Journals (Sweden)

    Simone eFulda

    2014-01-01

    Full Text Available Inhibitor of Apoptosis (IAP proteins are a family of proteins with antiapoptotic functions that contribute to the evasion of apoptosis, a form of programmed cell death. IAP proteins are expressed at high levels in a variety of human cancers including childhood acute leukemia. This elevated expression has been associated with unfavorable prognosis and poor outcome. Therefore, IAP proteins are currently exploited as therapeutic targets for cancer drug discovery. Consequently, small-molecule inhibitors or antisense oligonucleotides directed against IAP proteins have been developed over the last years. Indeed, IAP antagonists proved to exhibit in vitro and in vivo antitumor activities against childhood pediatric leukemia in several preclinical studies. Thus, targeting IAP proteins represents a promising molecular targeted strategy to overcome apoptosis resistance in childhood leukemia which warrants further exploitation.

  13. [Development of a batched image delete system for multi-vender picture archiving and communication system environment].

    Science.gov (United States)

    Yamada, Kenji; Amano, Masafumi; Yuasa, Masao; Yamamoto, Yuichiro; Tada, Akihisa; Harada, Masafumi

    2014-01-01

    A picture archiving and communication system (PACS) for multi-vendor imaging servers is useful, since it can provide a variety of image-processing services. However, to delete an image file in the PACS, it is necessary to delete not only the image but all its associated images that are stored in multiple servers: this is a lengthy and painstaking process. To reduce this workload, we have developed a system consisting of a computer program with a graphical user interface that can delete the target image and all related images by means of batch processing. The developed system creates an extensible markup language (XML)-format file that describes the operation for deleting an image and forwards the XML file to the main server. Using a Windows file-sharing system (SMB/CIFS), each server shares the XML file and deletes the images in its own database in response to the instructions described in the XML file. We can also rigorously manage information concerning the deleted images using the information that is output from the main server to external storage. We also discuss the degree of load reduction in our system compared with that of ordinary systems.

  14. cIAP1 regulates TNF-mediated cdc42 activation and filopodia formation.

    Science.gov (United States)

    Marivin, A; Berthelet, J; Cartier, J; Paul, C; Gemble, S; Morizot, A; Boireau, W; Saleh, M; Bertoglio, J; Solary, E; Dubrez, L

    2014-11-27

    Tumour necrosis factor-α (TNF) is a cytokine endowed with multiple functions, depending on the cellular and environmental context. TNF receptor engagement induces the formation of a multimolecular complex including the TNFR-associated factor TRAF2, the receptor-interaction protein kinase RIP1 and the cellular inhibitor of apoptosis cIAP1, the latter being essential for NF-κB activation. Here, we show that cIAP1 also regulates TNF-induced actin cytoskeleton reorganization through a cdc42-dependent, NF-κB-independent pathway. Deletion of cIAP1 prevents TNF-induced filopodia and cdc42 activation. The expression of cIAP1 or its E3-ubiquitin ligase-defective mutant restores the ability of cIAP1(-/-) MEFs to produce filopodia, whereas a cIAP1 mutant unable to bind TRAF2 does not. Accordingly, the silencing of TRAF2 inhibits TNF-mediated filopodia formation, whereas silencing of RIP1 does not. cIAP1 directly binds cdc42 and promotes its RhoGDIα-mediated stabilization. TNF decreases cIAP1-cdc42 interaction, suggesting that TNF-induced recruitment of cIAP1/TRAF2 to the receptor releases cdc42, which in turn triggers actin remodeling. cIAP1 also regulates cdc42 activation in response to EGF and HRas-V12 expression. A downregulation of cIAP1 altered the cell polarization, the cell adhesion to endothelial cells and cell intercalation, which are cdc42-dependent processes. Finally, we demonstrated that the deletion of cIAP1 regulated the HRas-V12-mediated transformation process, including anchorage-dependent cell growth, tumour growth in a xenograft model and the development of experimental metastasis in the lung.

  15. Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination

    Science.gov (United States)

    de Almagro, M C; Goncharov, T; Newton, K; Vucic, D

    2015-01-01

    Necroptosis is a caspase-independent regulated type of cell death that relies on receptor-interacting protein kinases RIP1 (receptor-interacting protein kinases 1) and RIP3. Tumor necrosis factor-α (TNFα)-stimulated assembly of the TNFR1 (TNF receptor 1)-associated signaling complex leads to the recruitment of RIP1, whose ubiquitination is mediated by the cellular inhibitors of apoptosis (c-IAPs). Translocation of RIP1 to the cytoplasm and association of RIP1 with the necrosome is believed to correlate with deubiquitination of RIP1. However, we found that RIP1 is ubiquitinated with K63 and linear polyubiquitin chains during TNFα, IAP antagonist BV6 and caspase inhibitor zVAD-fmk-induced necroptotic signaling. Furthermore, ubiquitinated RIP1 is associated with the necrosome, and RIP1 ubiquitination in the necrosome coincides with RIP3 phosphorylation. Both cellular IAPs and LUBAC (linear ubiquitin chain assembly complex) modulate RIP1 ubiquitination in IAP antagonist-treated necrotic cells, but they use different mechanisms. c-IAP1 regulates RIP1 recruitment to the necrosome without directly affecting RIP1 ubiquitination, whereas HOIP and HOIL1 mediate linear ubiquitination of RIP1 in the necrosome, but are not essential for necrosome formation. Knockdown of the E3 ligase c-IAP1 decreased RIP1 ubiquitination, necrosome assembly and necroptosis induced by TNFα, BV6 and zVAD-fmk. c-IAP1 deficiency likely decreases necroptotic cell death through the activation of the noncanonical NF-κB pathway and consequent c-IAP2 upregulation. The ability to upregulate c-IAP2 could determine whether c-IAP1 absence will have a positive or negative impact on TNFα-induced necroptotic cell death and necrosome formation. Collectively, these results reveal unexpected complexity of the roles of IAP proteins, IAP antagonists and LUBAC in the regulation of necrosome assembly. PMID:26111062

  16. The IAP family: endogenous caspase inhibitors with multiple biological acti- viti

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    IAPs (inhibitors of apoptosis) are a family of proteins containing one or more characteristic BIR domains. These proteins have multiple biological activities that include binding and inhibiting caspases, regulating cell cycle progression, and modulating receptor-mediated signal transduction. Our recent studies found the IAP family members XIAP and c-IAP1 are ubiquitinated and degraded in proteasomes in response to apoptoticstimuli in T cells, and their degradation appears to be important for T cells to commit to death. In addition to three BIR domains, each of these IAPs also contains a RING finger domain. We found this region confers ubiquitin protease ligase (E3) activity to IAPs, and is responsible for the auto-ubiquitination and degradation of IAPs after an apoptotic stimulus. Given the fact that IAPs can bind a variety of proteins, such as caspases and TRAFs, it will be of interest to characterize potential substrates of the E3 activity of IAPs and the effects of ubiquitination by IAPs on signal transduction, cell cycle, and apoptosis.

  17. Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity

    DEFF Research Database (Denmark)

    Damgaard, Rune B; Gyrd-Hansen, Mads

    2011-01-01

    as important regulators of innate immune signaling downstream of pattern recognition receptors (PRRs) such as Toll-like receptor 4 (TLR4), the nucleotide-binding oligomerization domain 1 (NOD1) and NOD2 receptors, and the retinoic acid-inducible gene (RIG)-I receptor. Recent evidence suggests that cIAP1, cIAP2......, and XIAP facilitate ubiquitin-dependent signaling activated by these PRRs and mediate activation of nuclear factor-kappa B (NF-kappaB) transcription factors as well as the MAP kinases p38 and JNK. Here, we review the current understanding of IAP-mediated PRR signaling and how IAP proteins might present...

  18. IAP第四代大气环流模式的气候系统模式模拟性能评估%Assessments of the Climate System Model (CAS-ESM-C) Using IAP AGCM4 as Its Atmospheric Component

    Institute of Scientific and Technical Information of China (English)

    孙泓川; 周广庆; 曾庆存

    2012-01-01

    This paper assesses the performance of a new climate system model, namely CAS-ESM-C (Chinese Academy of Sciences-Earth System Model-Climate system component), which employs the recently improved version of IAP AGCM, namely IAP AGCM4, as its atmospheric component This paper first describes the development and framework of the model briefly, and then evaluates the performances of the model in simulating the climate mean states of the atmosphere, land surface, ocean, and sea ice. Some aspects of the seasonal cycle and interannual variability are also analyzed. The results indicate that the CAS-ESM-C succeeds in controlling the long-term climate drift and has acceptable performances in realistically reproducing the climate mean states of the atmosphere, ocean, land surface and sea ice. The CAS-ESM-C also successfully reproduces the seasonal cycle of SST over the tropical Pacific and the seasonal cycle of the sea ice cover in the Arctic. The seasonal migration of monsoon rain band is well reproduced in the model, indicating the acceptable performance of the East Asian monsoon simulation. Except for the slight underestimation of the ENSO period and overestimation of the average amplitude, other characteristics of interannual variability over the tropical Pacific are well reproduced in the CAS-ESM-C. It is particularly important that, benefiting from the realistic simulation of the seasonal cycle of SST over the tropical Pacific, a "phase - locked" phenomenon appears in the simulated ENSO, which is hardly reproduced in other coupled models. The main deficiency of the CAS-ESM-C is the tropic bias, which is common in other coupled models. Some analyses are made to reveal the possible reason behind these simulation biases especially the tropical bias. The results suggest that the biases in the atmosphere which are amplified by the ocean - atmosphere feedback are the key reasons of the tropic bias in the coupled system. According to the analyses of the biases, future

  19. The Impact of the Picture Exchange Communication System on Requesting and Speech Development in Preschoolers with Autism Spectrum Disorders and Similar Characteristics

    Science.gov (United States)

    Ganz, Jennifer B.; Simpson, Richard L.; Corbin-Newsome, Jawanda

    2008-01-01

    By definition children with autism spectrum disorders (ASD) experience difficulty understanding and using language. Accordingly, visual and picture-based strategies such as the Picture Exchange Communication System (PECS) show promise in ameliorating speech and language deficits. This study reports the results of a multiple baseline across…

  20. Expression of IAP family proteins and its clinical importance in breast cancer patients.

    Science.gov (United States)

    Pluta, P; Jeziorski, A; Cebula-Obrzut, A Pluta B; Wierzbowska, A; Piekarski, J; Smolewski, P

    2015-01-01

    Inhibitor of apoptosis (IAP) family proteins is involved in mechanisms of resistance to apoptosis in various cancer cells. The aim of this study was to assess the expression of selected IAP proteins such as XIAP, cIAP-1, cIAP-2 and survivin in breast cancer patients and evaluates their relationship with the prognostic and predictive factors and their impact to overall survival (OS) and progression free survival (PFS). The study was conducted with the use of tissue samples prospectively collected from 92 previously untreated female breast cancer patients. The control encompassed 10 fibroadenoma patients. The expression of XIAP, cIAP-1, cIAP-2 and survivin was assessed using flow multicolor cytometry. XIAP expression was present in 99 % of the breast cancer patients (91/92) with the median expression 13.65% (range 1-66.8%). Expression of XIAP in breast cancer was significantly higher compared to the control group (p=0.006). Median expression of cIAP-1, cIAP-2 and survivin in the study group was 25.95% (range 0.8-83.7%), 16.7% (range 1-53.2%) and 4.6% (range 0-43%) respectively. In the rank Spearman test, strong correlations (pproteins and survival. However, low expression of XIAP in breast cancer showed trend to longer PFS (p=0.08). XIAP, cIAP-1 cIAP-2 and survivin participate in antiapoptotic mechanisms in breast cancer and XIAP and survivin seem to have the most significant prognostic importance. Further studies are needed to establish more complete prognostic and predictive values of IAP family proteins in breast cancer patients.

  1. How many people does it take to operate a picture archiving and communication system?

    Science.gov (United States)

    Honea, R

    2001-06-01

    The most frequently asked question without a correct answer is: "Just how many people does it take to operate a picture archiving and communication system (PACS)?" At Texas Children's Hospital, our consensus is that we do not yet know. As soon as we felt we had adequate staffing to provide timely response for routine services, we found that including the Intensive Care Units (ICUs) increased our demand for urgent response beyond our capacity. The addition of inpatient bedside imaging to PACS also increased the demand for round-the-clock and weekend PACS services. Our answer to the staffing question changes every year, in accordance with changes in the scope of services that our PACS is expected to provide. Our administration drew up a 5-year plan for PACS implementation, concentrating on purchase and installation of equipment, but neglected to estimate requirements for full-time equivalents (FTEs) for PACS. Our administration reasonably assumed that existing employees would be galvanized into PACS personnel. It is now clear that new FTEs need to be created strictly for the PACS service. Our 5-year plan also did not anticipate significant changes in the extent of our healthcare enterprise. Our PACS accommodates limited remote service: providing a PACS Analyst to travel to the site when a problem is not resolved remotely is another demand on staffing. Our PACS service was formed using staffing numbers based on assumptions about the minimum number of employees needed to perform routine duties, field trouble calls, conduct training, and work on special projects, such as adding new acquisition modalities or troubleshooting longstanding problems. This staffing was based on a single shift operation, with on-call coverage for second, third, and weekend shifts. The number of employees also considered absences for vacation, sick leave, and training. The service has administrative overhead that should be covered by a secretary. Someone is also needed to supervise the team

  2. Aversive picture processing: effects of a concurrent task on sustained defensive system engagement.

    Science.gov (United States)

    Wangelin, Bethany C; Löw, Andreas; McTeague, Lisa M; Bradley, Margaret M; Lang, Peter J

    2011-01-01

    Viewing a series of aversive pictures prompts emotional reactivity reflecting sustained defensive engagement. The present study examined the effects of a concurrent visual task on autonomic, somatic, electrocortical, and facial components of this defensive state. Results indicated that emotional activation was largely preserved despite continuous visual distraction, although evidence of attenuation was observed in startle reflex and electrocortical measures. Concurrent task-specific reactivity was also apparent, suggesting that motivational circuits can be simultaneously activated by stimuli with intrinsic survival significance and instructed task significance and that these processes interact differently across the separate components of defensive engagement.

  3. Effects of cIAP-1, cIAP-2 and XIAP triple knockdown on prostate cancer cell susceptibility to apoptosis, cell survival and proliferation.

    LENUS (Irish Health Repository)

    Gill, Catherine

    2009-01-01

    BACKGROUND: Manipulating apoptotic resistance represents an important strategy for the treatment of hormone refractory prostate cancer. We hypothesised that the Inhibitor of Apoptosis (IAP) Proteins may be mediating this resistance and knockdown of cIAP-1, cIAP-2 and XIAP would increase sensitivity to apoptosis. METHODS: cIAP-1, cIAP-2 and XIAP where knocked down either individually or in combination using siRNA in androgen independent prostate cancer PC-3 cells as confirmed by real-time PCR and western blotting. Cells were then treated with TRAIL, Etoposide, or Tunicamycin, and apoptosis assessed by PI DNA staining. Apoptosis was confirmed with Annexin V labelling and measurement of PARP cleavage, and was inhibited using the pan-caspase inhibitor, zVAD.fmk. Clonogenic assays and assessment of ID-1 expression by western blotting were used to measure recovery and proliferation. RESULTS: PC-3 are resistant to TRAIL induced apoptosis and have elevated expression of cIAP-1, cIAP-2 and XIAP. Combined knockdown sensitised PC-3 to TRAIL induced apoptosis, but not to Etoposide or Tunicmycin, with corresponding increases in caspase activity and PARP cleavage which was inhibited by ZVAD.fmk. Triple knock down decreased proliferation which was confirmed by decreased ID-1 expression. CONCLUSION: Simultaneous knock down of the IAPs not only sensitised the PC-3 to TRAIL but also inhibited their proliferation rates and clonogenic survival. The inability to alter sensitivity to other triggers of apoptosis suggests that this effect is specific for death receptor pathways and knock down might facilitate immune-surveillance mechanisms to counter cancer progression and, in combination with therapeutic approaches using TRAIL, could represent an important treatment strategy.

  4. Effects of cIAP-1, cIAP-2 and XIAP triple knockdown on prostate cancer cell susceptibility to apoptosis, cell survival and proliferation

    Directory of Open Access Journals (Sweden)

    Dowling Catherine

    2009-06-01

    Full Text Available Abstract Background Manipulating apoptotic resistance represents an important strategy for the treatment of hormone refractory prostate cancer. We hypothesised that the Inhibitor of Apoptosis (IAP Proteins may be mediating this resistance and knockdown of cIAP-1, cIAP-2 and XIAP would increase sensitivity to apoptosis. Methods cIAP-1, cIAP-2 and XIAP where knocked down either individually or in combination using siRNA in androgen independent prostate cancer PC-3 cells as confirmed by real-time PCR and western blotting. Cells were then treated with TRAIL, Etoposide, or Tunicamycin, and apoptosis assessed by PI DNA staining. Apoptosis was confirmed with Annexin V labelling and measurement of PARP cleavage, and was inhibited using the pan-caspase inhibitor, zVAD.fmk. Clonogenic assays and assessment of ID-1 expression by western blotting were used to measure recovery and proliferation. Results PC-3 are resistant to TRAIL induced apoptosis and have elevated expression of cIAP-1, cIAP-2 and XIAP. Combined knockdown sensitised PC-3 to TRAIL induced apoptosis, but not to Etoposide or Tunicmycin, with corresponding increases in caspase activity and PARP cleavage which was inhibited by ZVAD.fmk. Triple knock down decreased proliferation which was confirmed by decreased ID-1 expression. Conclusion Simultaneous knock down of the IAPs not only sensitised the PC-3 to TRAIL but also inhibited their proliferation rates and clonogenic survival. The inability to alter sensitivity to other triggers of apoptosis suggests that this effect is specific for death receptor pathways and knock down might facilitate immune-surveillance mechanisms to counter cancer progression and, in combination with therapeutic approaches using TRAIL, could represent an important treatment strategy.

  5. IAP/APA evidence-based guidelines for the management of acute pancreatitis

    NARCIS (Netherlands)

    Goor, H. van

    2013-01-01

    BACKGROUND: There have been substantial improvements in the management of acute pancreatitis since the publication of the International Association of Pancreatology (IAP) treatment guidelines in 2002. A collaboration of the IAP and the American Pancreatic Association (APA) was undertaken to revise t

  6. IAP/APA evidence-based guidelines for the management of acute pancreatitis

    NARCIS (Netherlands)

    Goor, H. van

    2013-01-01

    BACKGROUND: There have been substantial improvements in the management of acute pancreatitis since the publication of the International Association of Pancreatology (IAP) treatment guidelines in 2002. A collaboration of the IAP and the American Pancreatic Association (APA) was undertaken to revise

  7. IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer

    DEFF Research Database (Denmark)

    Gyrd-Hansen, Mads; Meier, Pascal

    2010-01-01

    . The development of such inhibitors has radically changed our knowledge of the signalling processes that are regulated by IAPs. Recent studies indicate that IAPs not only regulate caspases and apoptosis, but also modulate inflammatory signalling and immunity, mitogenic kinase signalling, proliferation and mitosis...

  8. cIAP-1 controls innate immunity to C. pneumoniae pulmonary infection.

    Directory of Open Access Journals (Sweden)

    Hridayesh Prakash

    Full Text Available The resistance of epithelial cells infected with Chlamydophila pneumoniae for apoptosis has been attributed to the induced expression and increased stability of anti-apoptotic proteins called inhibitor of apoptosis proteins (IAPs. The significance of cellular inhibitor of apoptosis protein-1 (cIAP-1 in C. pneumoniae pulmonary infection and innate immune response was investigated in cIAP-1 knockout (KO mice using a novel non-invasive intra-tracheal infection method. In contrast to wildtype, cIAP-1 knockout mice failed to clear the infection from their lungs. Wildtype mice responded to infection with a strong inflammatory response in the lung. In contrast, the recruitment of macrophages was reduced in cIAP-1 KO mice compared to wildtype mice. The concentration of Interferon gamma (IFN-gamma was increased whereas that of Tumor Necrosis Factor (TNF-alpha was reduced in the lungs of infected cIAP-1 KO mice compared to infected wildtype mice. Ex vivo experiments on mouse peritoneal macrophages and splenocytes revealed that cIAP-1 is required for innate immune responses of these cells. Our findings thus suggest a new immunoregulatory role of cIAP-1 in the course of bacterial infection.

  9. Knowledge From Pictures (KFP)

    Science.gov (United States)

    Truszkowski, Walt; Paterra, Frank; Bailin, Sidney

    1993-01-01

    The old maxim goes: 'A picture is worth a thousand words'. The objective of the research reported in this paper is to demonstrate this idea as it relates to the knowledge acquisition process and the automated development of an expert system's rule base. A prototype tool, the Knowledge From Pictures (KFP) tool, has been developed which configures an expert system's rule base by an automated analysis of and reasoning about a 'picture', i.e., a graphical representation of some target system to be supported by the diagnostic capabilities of the expert system under development. This rule base, when refined, could then be used by the expert system for target system monitoring and fault analysis in an operational setting. Most people, when faced with the problem of understanding the behavior of a complicated system, resort to the use of some picture or graphical representation of the system as an aid in thinking about it. This depiction provides a means of helping the individual to visualize the bahavior and dynamics of the system under study. An analysis of the picture augmented with the individual's background information, allows the problem solver to codify knowledge about the system. This knowledge can, in turn, be used to develop computer programs to automatically monitor the system's performance. The approach taken is this research was to mimic this knowledge acquisition paradigm. A prototype tool was developed which provides the user: (1) a mechanism for graphically representing sample system-configurations appropriate for the domain, and (2) a linguistic device for annotating the graphical representation with the behaviors and mutual influences of the components depicted in the graphic. The KFP tool, reasoning from the graphical depiction along with user-supplied annotations of component behaviors and inter-component influences, generates a rule base that could be used in automating the fault detection, isolation, and repair of the system.

  10. The Function of SeMNPV IAP3 in Mammalian Cells

    Institute of Scientific and Technical Information of China (English)

    Li-na ZHU; Chun-lei MEI; Zhong-xin ZHANG

    2008-01-01

    The baculoviral inhibitors of apoptosis play a significant role in infectivity and viral host-range, which make them potential candidates for the engineering and improvement of baculovirus insecticidal. The iap3 gene of Spodoptera exigua nucleopolyhedrovirus (SeMNPV), amplified by PCR, was 939 bp encoding IAP3. The PCR product was cloned into EcoR I/Bam H I of the plasmid pEGFP-C1. GFP was fused to the N-terminaus of IAP3 to study distribution in HEK293. It was observed that the plasmid expressing IAP3 significantly inhibited apoptosis induced by cisplatin in HEK293 cells. We conclude that the IAP3 of SeMNPV is functional in mammalian cells.

  11. Gaussification and entanglement distillation of continuous variable systems: a unifying picture

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, Earl; Eisert, Jens [Dahlem Center for Complex Quantum Systems, Freie Universitaet Berlin, 14195 Berlin (Germany)

    2012-07-01

    Distillation of entanglement using only Gaussian operations is an important primitive in quantum communication, quantum repeater architectures, and distributed quantum computing. Existing distillation protocols for continuous degrees of freedom are only known to converge to a Gaussian state when measurements yield precisely the vacuum outcome. In sharp contrast, non-Gaussian states can be deterministically converted into Gaussian states while preserving their second moments, albeit by usually reducing their degree of entanglement. In this work - based on a novel instance of a non-commutative central limit theorem - we introduce a picture general enough to encompass the known protocols leading to Gaussian states, and also demonstrate convergence for a class of new protocols. This gives the experimental option of balancing the merits of success probability against entanglement produced. The generality of results also opens up entirely new territory, by providing means of multi-partite distillation and more efficient hybrid quantum repeater schemes.

  12. Picture Archiving And Communication System%医学影像存储和通讯系统

    Institute of Scientific and Technical Information of China (English)

    胡伟标

    2001-01-01

    This article described the development and character of Picture Archiving and Communication System.The present information of Digital Image Communication in Medical 3.0.The technology of the communication and archiving in PACS.It made the evaluation and prospect for profits of PACS.%本文叙述了PACS的发展和特点:DICOM3.0的现状;PACS的通讯和存储技术;并对PACS的效益进行评价和展望。

  13. An evaluation of multiple-schedule variations to reduce high-rate requests in the picture exchange communication system.

    Science.gov (United States)

    Landa, Robin; Hanley, Gregory P

    2016-06-01

    Using procedures similar to those of Tiger, Hanley, and Heal (2006), we compared two multiple-schedule variations (S+/S- and S+ only) to treat high-rate requests for edible items in the Picture Exchange Communication System (PECS). Two individuals with autism participated, after they showed persistent requests for edible items after PECS training. Stimulus control was achieved only with the multiple schedule that involved presentation of a discriminative stimulus during reinforcement components and its removal during extinction components (S+ only). Discriminated requests were maintained for the 1 participant who experienced schedule thinning. © 2016 Society for the Experimental Analysis of Behavior.

  14. Global Coupled Ocean-Atmosphere General Circulation Models in LASG/IAP

    Institute of Scientific and Technical Information of China (English)

    俞永强; 张学洪; 郭裕福

    2004-01-01

    Coupled ocean-atmospheric general circulation models are the only tools to quantitatively simulate the climate system. Since the end of the 1980s, a group of scientists in the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics (LASG), Institute of Atmospheric Physics (IAP), Chinese Academy of Sciences (CAS), have been working to develop a global OGCM and a global coupled ocean-atmosphere general circulation model (CGCM). From the original flux anomalycoupling model developed in the beginning of the 1990s to the latest directly-coupling model, LASG scientists have developed four global coupled GCMs. This study summarizes the development history of these models and describes the third and fourth coupled GCMs and selected applications. Strengths and weaknesses of these models are highlighted.

  15. 基于JSP的图片轮播系统实现%System Implementation of Picture Carousel Based on JSP

    Institute of Scientific and Technical Information of China (English)

    谢红

    2016-01-01

    At present, general enterprises have set up a website,website can introduce enterprise,promote products,contact cus-tomers,improve image. The website in order to attract attention often uses the picture carousel function, system implementation of picture carousel can be achieved using JavaScript array or database in JSP files etc., in this paper, the realization methods and advantages and disadvantages of these two methods are introduced in detail.%目前,一般企业都建立了网站,网站可以介绍企业,推广产品,联系客户,提升形象。网站为了吸引注意力往往采用图片轮播功能,图片轮播可以采用JavaScript数组方式或者在JSP文件中使用数据库方式实现,JSP文件中使用数据库方式该文详细介绍了这两种方式各自的实现方法和优缺点。

  16. Streamlining the discovery, evaluation, and integration of data, models, and decision support systems: a big picture view (Invited)

    Science.gov (United States)

    Laniak, G.

    2013-12-01

    21st century environmental problems are wicked and require holistic systems thinking and solutions that integrate social and economic knowledge with knowledge of the environment. Computer-based technologies are fundamental to our ability to research and understand the relevant systems and to provide assessors and decision makers with appropriate data, tools, and strategies. There are significant science and technology challenges being confronted in an effort to streamline the movement of knowledge from its research and experience-based sources to its decision endpoints. In this presentation we explore this continuum and attempt to articulate a holistic and coherent picture of the relationship among the myriad elements of the environmental problem solving landscape. This is done in the hope that this view will enhance the ability of all environmental stakeholders to express their individual contributions in a technological form that will be accessible and usable to the greater community.

  17. Poly(I:C induces intense expression of c-IAP2 and cooperates with an IAP inhibitor in induction of apoptosis in cancer cells

    Directory of Open Access Journals (Sweden)

    Uzan Catherine

    2010-06-01

    Full Text Available Abstract Background There is increasing evidence that the toll-like receptor 3 (TLR3 is an interesting target for anti-cancer therapy. Unfortunately, most laboratory investigations about the impact of TLR3 stimulation on human malignant cells have been performed with very high concentrations - 5 to 100 μg/ml - of the prototype TLR3 ligand, poly(I:C. In a previous study focused on a specific type of human carcinoma - nasopharyngeal carcinoma - we have shown that concentrations of poly(I:C as low as 100 ng/ml are sufficient to induce apoptosis of malignant cells when combined to a pharmacological antagonist of the IAP family based on Smac mimicry. Methods This observation prompted us to investigate the contribution of the IAP family in cell response to poly(I:C in a variety of human malignant cell types. Results We report a rapid, intense and selective increase in c-IAP2 protein expression observed under stimulation by poly(I:C(500 ng/ml in all types of human malignant cells. In most cell types, this change in protein expression is underlain by an increase in c-IAP2 transcripts and dependent on the TLR3/TRIF pathway. When poly(I:C is combined to the IAP inhibitor RMT 5265, a cooperative effect in apoptosis induction and/or inhibition of clonogenic growth is obtained in a large fraction of carcinoma and melanoma cell lines. Conclusions Currently, IAP inhibitors like RMT 5265 and poly(I:C are the subject of separate therapeutic trials. In light of our observations, combined use of both types of compounds should be considered for treatment of human malignancies including carcinomas and melanomas.

  18. The Inhibitor of Apoptosis (IAPs) in Adaptive Response to Cellular Stress.

    Science.gov (United States)

    Marivin, Arthur; Berthelet, Jean; Plenchette, Stéphanie; Dubrez, Laurence

    2012-10-10

    Cells are constantly exposed to endogenous and exogenous cellular injuries. They cope with stressful stimuli by adapting their metabolism and activating various "guardian molecules." These pro-survival factors protect essential cell constituents, prevent cell death, and possibly repair cellular damages. The Inhibitor of Apoptosis (IAPs) proteins display both anti-apoptotic and pro-survival properties and their expression can be induced by a variety of cellular stress such as hypoxia, endoplasmic reticular stress and DNA damage. Thus, IAPs can confer tolerance to cellular stress. This review presents the anti-apoptotic and survival functions of IAPs and their role in the adaptive response to cellular stress. The involvement of IAPs in human physiology and diseases in connection with a breakdown of cellular homeostasis will be discussed.

  19. Targeting IAP (inhibitor of apoptosis) proteins for therapeutic intervention in tumors.

    Science.gov (United States)

    Vucic, Domagoj

    2008-03-01

    Apoptosis, or programmed cell death, is a cell suicide process with a major role in development and homeostasis in vertebrates and invertebrates. Dysregulation of apoptosis leading to early cell death or the absence of normal cell death contributes to a number of disease conditions including neurodegenerative diseases and cancer. Inhibition of apoptosis enhances the survival of cancer cells and facilitates their escape from immune surveillance and cytotoxic therapies. Inhibitor of apoptosis (IAP) proteins, a family of anti-apoptotic regulators that block cell death in response to diverse stimuli through interactions with inducers and effectors of apoptosis are among the principal molecules contributing to this phenomenon. IAP proteins are expressed in the majority of human malignancies at elevated levels and play an active role in promoting tumor maintenance through the inhibition of cellular death and participation in signaling pathways associated with malignancies. Herein, the role of IAP proteins in cancer and strategies toward targeting IAP proteins for therapeutic intervention will be discussed.

  20. Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity

    DEFF Research Database (Denmark)

    Damgaard, Rune B; Gyrd-Hansen, Mads

    2011-01-01

    Inflammatory and innate immune signaling in response to recognition of pathogens is essential for immunity and host survival. However, deregulation may lead to detrimental pathologies including immunodeficiency, inflammatory diseases, and cancer. Inhibitor of apoptosis (IAP) proteins have emerged...

  1. Voyager picture of Jupiter

    Science.gov (United States)

    1998-01-01

    NASA's Voyager 1 took this picture of the planet Jupiter on Saturday, Jan. 6, the first in its three-month-long, close-up investigation of the largest planet. The spacecraft, flying toward a March 5 closest approach, was 35.8 million miles (57.6 million kilometers) from Jupiter and 371.7 million miles (598.2 million kilometers) from Earth when the picture was taken. As the Voyager cameras begin their meteorological surveillance of Jupiter, they reveal a dynamic atmosphere with more convective structure than had previously been thought. While the smallest atmospheric features seen in this picture are still as large as 600 miles (1,000 kilometers) across, Voyager will be able to detect individual storm systems as small as 3 miles (5 kilometers) at closest approach. The Great Red Spot can be seen near the limb at the far right. Most of the other features are too small to be seen in terrestrial telescopes. This picture was transmitted to the Jet Propulsion Laboratory through the Deep Space Network's tracking station at Madrid, Spain. The Voyager Project is managed for NASA by Caltech's Jet Propulsion Laboratory.

  2. Integrated, systems metabolic picture of acetone-butanol-ethanol fermentation by Clostridium acetobutylicum.

    Science.gov (United States)

    Liao, Chen; Seo, Seung-Oh; Celik, Venhar; Liu, Huaiwei; Kong, Wentao; Wang, Yi; Blaschek, Hans; Jin, Yong-Su; Lu, Ting

    2015-07-07

    Microbial metabolism involves complex, system-level processes implemented via the orchestration of metabolic reactions, gene regulation, and environmental cues. One canonical example of such processes is acetone-butanol-ethanol (ABE) fermentation by Clostridium acetobutylicum, during which cells convert carbon sources to organic acids that are later reassimilated to produce solvents as a strategy for cellular survival. The complexity and systems nature of the process have been largely underappreciated, rendering challenges in understanding and optimizing solvent production. Here, we present a system-level computational framework for ABE fermentation that combines metabolic reactions, gene regulation, and environmental cues. We developed the framework by decomposing the entire system into three modules, building each module separately, and then assembling them back into an integrated system. During the model construction, a bottom-up approach was used to link molecular events at the single-cell level into the events at the population level. The integrated model was able to successfully reproduce ABE fermentations of the WT C. acetobutylicum (ATCC 824), as well as its mutants, using data obtained from our own experiments and from literature. Furthermore, the model confers successful predictions of the fermentations with various network perturbations across metabolic, genetic, and environmental aspects. From foundation to applications, the framework advances our understanding of complex clostridial metabolism and physiology and also facilitates the development of systems engineering strategies for the production of advanced biofuels.

  3. Analysis of expression, cellular localization, and function of three inhibitors of apoptosis (IAPs from Litopenaeus vannamei during WSSV infection and in regulation of antimicrobial peptide genes (AMPs.

    Directory of Open Access Journals (Sweden)

    Pei-Hui Wang

    Full Text Available Inhibitors of apoptosis (IAPs play important roles in apoptosis and NF-κB activation. In this study, we cloned and characterized three IAPs (LvIAP1-3 from the Pacific white shrimp, Litopenaeusvannamei. LvIAP1-3 proteins shared signature domains and exhibited significant similarities with other IAP family proteins. The tissue distributions of LvIAP1-3 were studied. The expression of LvIAP1-3 was induced in the muscle after white spot syndrome virus (WSSV infection. LvIAP1 expression in the gill, hemocytes, hepatopancreas, and intestine was responsive to WSSV and Vibrioalginolyticus infections. LvIAP2 expression in the gill, hemocytes, and hepatopancreas was also responsive to WSSV infection. The expression of LvIAP3 in the gill, hemocytes, and intestine was reduced after V. alginolyticus infection. When overexpressed in Drosophila S2 cells, GFP labeled-LvIAP2 was distributed in the cytoplasm and appeared as speck-like aggregates in the nucleus. Both LvIAP1 and LvIAP3 were widely distributed throughout the cytoplasm and nucleus. The expression of LvIAP1, LvIAP2, and LvIAP3 was significantly knocked down by dsRNA-mediated gene silencing. In the gill of LvIAP1- or LvIAP3-silenced shrimp, the expression of WSSV VP28 was significantly higher than that of the dsGFP control group, suggesting that LvIAP1 and LvIAP3 may play protective roles in host defense against WSSV infection. Intriguingly, the LvIAP2-silenced shrimp all died within 48 hours after dsLvIAP2 injection. In the hemocytes of LvIAP2-silenced shrimps, the expression of antimicrobial peptide genes (AMPs, including Penaeidins, lysozyme, crustins, Vibriopenaeicidae-induced cysteine and proline-rich peptides (VICPs, was significantly downregulated, while the expression of anti-lipopolysaccharide factors (ALFs was upregulated. Moreover, LvIAP2 activated the promoters of the NF-κB pathway-controlled AMPs, such as shrimp Penaeidins and Drosophila drosomycin and attacin A, in Drosophila S2 cells

  4. [Modular project of the Picture Archiving and Communication System (PACS). Preliminary operational experience. I].

    Science.gov (United States)

    Dalla Palma, L; Ukovich, W; Stacul, F; Cuttin Zernich, R; Carbi, N; Giribona, P

    1990-01-01

    Since september 1988 a PAC System (Comm View by AT & T and Philips) has been operating in the Radiology Department of the University Hospital, Trieste. A research project is presently in progress aiming at providing factual evidence for the evaluation of this kind of systems as far as operational, technical, clinical and economic aspects are concerned. The general approach to this research consists in implementing and monitoring a PACS in a stepwise way, starting with a small system connected to some digital modalities only, in order to test the feasibility and effectiveness of the system within a Radiology Department, and to test the possibility of matching the PACS to the Radiological System. The present paper describes in detail the present configuration of this entry-level system and its technical features. The planned development (october 1989) is also depicted. Further developments devise at managing in an integrated way all the radiological images of the four hospitals of Trieste. At present, the PACS is currently used to manage and store on optical disks all the images acquired from the connected modalities plus the related reports, and to perform the reporting sessions for CT examinations (brain and abdomen). The present research effort is devoted to two main areas: clinical evaluation and operational analysis. The object of the operational analysis was the assessment of the impact of PACS on the operations of a Radiology Department. The general approach followed for this research consists in analysing the procedures as they are performed in the conventional way (manual operations), and comparing them to the way they are, or could be, performed using a PACS System (automatic operations). This stage of the project is divided into three phases, concerning respectively the analysis of the organization and operations before PACS, the analysis of the impact of PACS in its initial configuration and the forecast of the influence of PACS in its future setting. A

  5. Performance enhancement of a web-based picture archiving and communication system using commercial off-the-shelf server clusters.

    Science.gov (United States)

    Liu, Yan-Lin; Shih, Cheng-Ting; Chang, Yuan-Jen; Chang, Shu-Jun; Wu, Jay

    2014-01-01

    The rapid development of picture archiving and communication systems (PACSs) thoroughly changes the way of medical informatics communication and management. However, as the scale of a hospital's operations increases, the large amount of digital images transferred in the network inevitably decreases system efficiency. In this study, a server cluster consisting of two server nodes was constructed. Network load balancing (NLB), distributed file system (DFS), and structured query language (SQL) duplication services were installed. A total of 1 to 16 workstations were used to transfer computed radiography (CR), computed tomography (CT), and magnetic resonance (MR) images simultaneously to simulate the clinical situation. The average transmission rate (ATR) was analyzed between the cluster and noncluster servers. In the download scenario, the ATRs of CR, CT, and MR images increased by 44.3%, 56.6%, and 100.9%, respectively, when using the server cluster, whereas the ATRs increased by 23.0%, 39.2%, and 24.9% in the upload scenario. In the mix scenario, the transmission performance increased by 45.2% when using eight computer units. The fault tolerance mechanisms of the server cluster maintained the system availability and image integrity. The server cluster can improve the transmission efficiency while maintaining high reliability and continuous availability in a healthcare environment.

  6. Teaching Systems - Getting future IT entrepreneurs to see the full picture

    Directory of Open Access Journals (Sweden)

    Andrea Resmini

    2014-12-01

    Full Text Available Information is going everywhere. It is bleeding out of the Internet and out of personal computers, and it is being embedded into the real world. Mobile devices, networked resources, and real-time systems are making our interactions with information constant and ubiquitous. Information is becoming pervasive, and products and services are becoming parts of larger systems, many of these emergent, complex information-based ecosystems where participants are co-producers and where relationships between elements, channels and touchpoints are messy and non-linear. Still, by and large, within the area of informatics and information systems we teach management and design as if they were linear processes where cause and effect are easily ascertained and a solution readily provided. Could we try something different? How would that work and what results could it produce in terms of both learning outcomes and student satisfaction? This paper details the approach we followed and the early results we achieved in introducing business and informatics students to entrepreneurship and innovation through a holistic approach in the 2-year Master in IT, Management and Innovation at Jönköping International Business School (JIBS, in Jönköping, Sweden. 

  7. A comparative cost analysis of picture archiving and communications systems (PACS versus conventional radiology in the private sector

    Directory of Open Access Journals (Sweden)

    Indres Moodley

    2015-03-01

    Full Text Available Background: Radiology is rapidly advancing, with a global transition to digital imaging technology to improve productivity and enhance communication. The major challenge confronting radiology practices is to demonstrate cost savings and productivity gains when a picture archiving and communication system (PACS is established.Aim: To undertake an incremental cost analysis of PACS compared with conventional radiology to determine productivity gains, if any, at two private hospitals in Durban.Method: An incremental cost analysis for chest radiographs, computed tomography and magnetic resonance imaging brain scans with and without contrast were performed. The overall incremental cost for PACS in comparison with a conventional radiology site was determined. The net present value was also determined to evaluate the capital budgeting requirements for both systems.Results: The incremental cost of both capital and the radiology information system for installing PACS shows an expected increase. The incremental PACS image cost shows a reduction.Conclusion: The study provides a benchmark for the cost incurred when implementing PACS. It also provides a decision framework for radiology departments that plan to introduce PACS and helps to determine the feasibility of its introduction.

  8. 20世纪温度变化中自然变率和人为因素的影响:基于耦合气候模式的归因模拟%Contributions of natural and anthropogenic forcings in twentieth-century temperature change:results from LASG/IAP climate system model FGOALS_gl

    Institute of Scientific and Technical Information of China (English)

    满文敏; 周天军; 张丽霞; 吴波; 张洁

    2012-01-01

    Contributions of natural and anthropogenic forcings in the twentieth-century air temperature change are evaluated with a climate system model named FGOALS_gl developed at LASG/IAP. The HadCRUT3v dataset is used to validate the model. Observed warming trends on the global scale and in many regions are simulated more realistically in the all-forcing run thanin the natural-only forcing experiment. The simulations support that the twentieth-century global warming could have resulted from a combination of natural and anthropogenic forcings,with human-induced radiative forcing being the dominant cause of the pronounced late twentieth-century warming. For global and hemispheric means, external forcings could explain most of the variance;however, the tropical eastern Pacific and the North Atlantic are examples of regions where internal variability may dominate. Attributions generally become more difficult on regional scales due to both a decreasing externally forced signal level and an increasing internally generated noise level. The reproducibility of the air temperature averaged over China is lower than that of the global and hemispheric averages. Anthropogenic forcings are simulated to act as the dominant role for the late twentieth century warming over China.%本文基于中国科学院大气物理研究所大气科学和地球流体力学国家重点实验室(LASG/IAP)发展的气候系统模式FGOALS_gl对近百年气温变化的模拟,讨论了自然变率和人为因素对20世纪全球变暖的相对贡献.数值试验结果表明,在自然和人为因子的共同强迫作用下,耦合模式能够合理再现20世纪全球平均气温随时间的演变;仅在自然因子作用下,模式不能再现1970年以后的全球变暖.自然因素对20世纪第一次变暖的作用是显著的,但温室气体是20世纪后期变暖的主要原因.在这一定性结论基础上,进一步对近百年变化中自然和人为因素的相对贡献做定量的归因分析,结

  9. Picture Archiving And Communications Systems (PACS) And Radiation Therapy Planning: Data And Workstation Requirements

    Science.gov (United States)

    Reavis, R. J.; Zielonka, Jason S.

    1986-06-01

    PACS literature to date has emphasized the needs of diagnostic imaging; however, the ability to acquire, manipulate, and display data derived from multiple imaging modalities is also vital in the practice of radiation oncology and radiation therapy planning (RTP). Radiographic or scintigraphic images for RTP must include specific spatial calibration data, as well as data relating image acquisition to anatomic localization within the patient. The digital nature of PACS images and displays allows the radiation oncologist to interactively assist in evaluating whether or not near-by structures are tumor-free. The radiation oncologist may also need to review nonradiographic diagnostic images (e.g., endoscopic images or pathology tissue specimens). Finally, it must be possible to take data such as isodose lines and superimpose them onto images relating the proposed therapy field to patient anatomy. Not only would this be useful for the radiation oncologist, but it would also provide information currently not easily available to the diagnostician and useful in subsequent diagnostic efforts. The three-dimensional (volumetric) data creation for RTP is not currently widespread because of the difficulties in converting images into a coherent, reliable and registered data set; this is the unique contribution of PACS. Software must be developed to permit creation of volumetric models based on data derived from both planar images and various tomographic modalities, including calibration and localizaton data for accurate image registration and scaling. This will permit positive definition of tumor volume by diagnosticians and the radiation oncologists as an initial portion of the therapy planning process. As a part of the underlying data structure for such systems, there must be some uniformity of image format between modalities and vendors; this has been adequately addressed by the Digital Imaging and Communications Interface Standard recently adopted by the American College of

  10. A medical application integrating remote 3D visualization tools to access picture archiving and communication system on mobile devices.

    Science.gov (United States)

    He, Longjun; Ming, Xing; Liu, Qian

    2014-04-01

    With computing capability and display size growing, the mobile device has been used as a tool to help clinicians view patient information and medical images anywhere and anytime. However, for direct interactive 3D visualization, which plays an important role in radiological diagnosis, the mobile device cannot provide a satisfactory quality of experience for radiologists. This paper developed a medical system that can get medical images from the picture archiving and communication system on the mobile device over the wireless network. In the proposed application, the mobile device got patient information and medical images through a proxy server connecting to the PACS server. Meanwhile, the proxy server integrated a range of 3D visualization techniques, including maximum intensity projection, multi-planar reconstruction and direct volume rendering, to providing shape, brightness, depth and location information generated from the original sectional images for radiologists. Furthermore, an algorithm that changes remote render parameters automatically to adapt to the network status was employed to improve the quality of experience. Finally, performance issues regarding the remote 3D visualization of the medical images over the wireless network of the proposed application were also discussed. The results demonstrated that this proposed medical application could provide a smooth interactive experience in the WLAN and 3G networks.

  11. Roles of c-IAP proteins in TNF receptor family activation of NF-κB signaling.

    Science.gov (United States)

    Varfolomeev, Eugene; Goncharov, Tatiana; Vucic, Domagoj

    2015-01-01

    Precise regulation of survival and signaling pathways is essential for proper maintenance of organismal homeostasis, development, and immune defense. Inhibitor of apoptosis (IAP) proteins are evolutionarily conserved regulators of cell death and immune signaling that impact numerous cellular processes. Initially characterized as inhibitors of apoptosis, the ubiquitin ligase activity of IAP proteins is critical for modulating various signaling pathways (e.g., NF-κB, MAPK) and cellular fate. Cellular IAP1 and IAP2 regulate the pro-survival canonical NF-κB pathway by ubiquitinating RIP1 and enabling recruitment of kinase (IKK) and E3 ligase (LUBAC) complexes. On the other hand, c-IAP1 and c-IAP2 are negative regulators of noncanonical NF-κB signaling by promoting ubiquitination and consequent degradation of the NF-κB-inducing kinase NIK. In this article, we describe the involvement of c-IAP1 and c-IAP2 in NF-κB signaling and provide detailed methodology for examining how c-IAPs exert their functional roles.

  12. Application of Computed Tomography Processed by Picture Archiving and Communication Systems in the Diagnosis of Acute Achilles Tendon Rupture

    Directory of Open Access Journals (Sweden)

    Hai-Peng Xue

    2016-01-01

    Full Text Available The applications of CT examination in the diagnosis of the acute Achilles tendon rupture (AATR were investigated. A total of 36 patients with suspected acute Achilles tendon rupture were tested using physical examination, ultrasound, and 3DCT scanning, respectively. Then, surgery was performed for the patients who showed positive result in at least two of the three tests for AATR. 3DVR, MPR, and the other CT scan image processing and diagnosis were conducted in PACS (picture archiving and communication system. PACS was also used to measure the length of distal broken ends of the Achilles tendon (AT to tendon calcaneal insertion. Our study indicated that CT has the highest accuracy in diagnosis of acute Achilles tendon complete rupture. The length measurement is matched between PACS and those actually measured in operation. CT not only demonstrates more details directly in three dimensions especially with the rupture involved calcaneal insertion flap but also locates the rupture region for percutaneous suture by measuring the length of distal stump in PACS without the effect of the position of ankle. The accuracy of CT diagnosis for Achilles tendon partial rupture is yet to be studied.

  13. Study of Radiologic Technologists' Perceptions of Picture Archiving and Communication System (PACS) Competence and Educational Issues in Western Australia.

    Science.gov (United States)

    Floyd, Daniel M; Trepp, Errol R; Ipaki, Maryam; Ng, Curtise K C

    2015-06-01

    Although the implementation of picture archiving and communication system (PACS) could increase productivity of radiology departments, this depends on factors such as the PACS competence of radiologic technologists (RTs). The purpose of this study was to investigate the RTs' perceptions of PACS competence and educational issues in Western Australia (WA). A hardcopy questionnaire was distributed to WA RTs for obtaining their perceptions of PACS competence and educational issues. Descriptive (percentage of frequency, mean and standard deviation) and inferential statistics (t test and analysis of variance) were used to analyze the responses of the multiple choice and five-point scale questions from the returned questionnaires. The questionnaire response rate was 57.7% (173 out of 300). The mean values of all PACS competence questions except questions 2e-g are in the range of 3.9-4.9, i.e., around competent to very competent. Participants indicated they received adequate PACS training (mean 3.8). Statistically significant variables influencing RTs' perceptions of their PACS competence and educational issues including the age (p education received (p education programs should be tailored to different RTs' groups. For example, multiple training modules might be necessary to support the PACS competence development of older RTs and those with lower general computer literacy.

  14. Selection of words for implementation of the Picture Exchange Communication System - PECS in non-verbal autistic children.

    Science.gov (United States)

    Ferreira, Carine; Bevilacqua, Monica; Ishihara, Mariana; Fiori, Aline; Armonia, Aline; Perissinoto, Jacy; Tamanaha, Ana Carina

    2017-03-09

    It is known that some autistic individuals are considered non-verbal, since they are unable to use verbal language and barely use gestures to compensate for the absence of speech. Therefore, these individuals' ability to communicate may benefit from the use of the Picture Exchange Communication System - PECS. The objective of this study was to verify the most frequently used words in the implementation of PECS in autistic children, and on a complementary basis, to analyze the correlation between the frequency of these words and the rate of maladaptive behaviors. This is a cross-sectional study. The sample was composed of 31 autistic children, twenty-five boys and six girls, aged between 5 and 10 years old. To identify the most frequently used words in the initial period of implementation of PECS, the Vocabulary Selection Worksheet was used. And to measure the rate of maladaptive behaviors, we applied the Autism Behavior Checklist (ABC). There was a significant prevalence of items in the category "food", followed by "activities" and "beverages". There was no correlation between the total amount of items identified by the families and the rate of maladaptive behaviors. The categories of words most mentioned by the families could be identified, and it was confirmed that the level of maladaptive behaviors did not interfere directly in the preparation of the vocabulary selection worksheet for the children studied.

  15. Application of Computed Tomography Processed by Picture Archiving and Communication Systems in the Diagnosis of Acute Achilles Tendon Rupture.

    Science.gov (United States)

    Xue, Hai-Peng; Liu, Xin-Wei; Tian, Jing; Xie, Bing; Yang, Chao; Zhang, Hao; Zhou, Da-Peng

    2016-01-01

    The applications of CT examination in the diagnosis of the acute Achilles tendon rupture (AATR) were investigated. A total of 36 patients with suspected acute Achilles tendon rupture were tested using physical examination, ultrasound, and 3DCT scanning, respectively. Then, surgery was performed for the patients who showed positive result in at least two of the three tests for AATR. 3DVR, MPR, and the other CT scan image processing and diagnosis were conducted in PACS (picture archiving and communication system). PACS was also used to measure the length of distal broken ends of the Achilles tendon (AT) to tendon calcaneal insertion. Our study indicated that CT has the highest accuracy in diagnosis of acute Achilles tendon complete rupture. The length measurement is matched between PACS and those actually measured in operation. CT not only demonstrates more details directly in three dimensions especially with the rupture involved calcaneal insertion flap but also locates the rupture region for percutaneous suture by measuring the length of distal stump in PACS without the effect of the position of ankle. The accuracy of CT diagnosis for Achilles tendon partial rupture is yet to be studied.

  16. Comparing the Picture Exchange Communication System and the iPad™ for Communication of Students with Autism Spectrum Disorder and Developmental Delay

    Science.gov (United States)

    Hill, Doris Adams; Flores, Margaret M.

    2014-01-01

    Both picture exchange, a low-tech picturebased communication system, and technologybased interventions, such as the iPad™ with communication application, are emerging treatments for students with autism spectrum disorder (ASD), according to the National Autism Center (2009). Recently, investigations regarding the use of the Apple iPad™ to…

  17. Effects of the Picture Exchange Communication System (PECS) on Maladaptive Behavior in Children with Autism Spectrum Disorders (ASD): A Review of the Literature

    Science.gov (United States)

    Battaglia, Dana; McDonald, Mary E.

    2015-01-01

    This paper provides an overview of the literature investigating the functional relationship between the use of the Picture Exchange Communication System (PECS) and maladaptive behavior (i.e., aggression, tantrums) in individuals with autism spectrum disorders (ASD). Digital searches were conducted to identify single subject design studies…

  18. Preliminary Validation of the Scale of Attitudes from Psychologists and psychology students (IAPE

    Directory of Open Access Journals (Sweden)

    Cristóbal Guerra

    2015-11-01

    Full Text Available The process of training psychologists involves addressing both technical skills and generic or attitudinal competencies. However, there are not instruments for assessing attitudinal skills in psychologists and psychology students. Therefore, the aim of the study was to describe the process of construction and preliminary validation of an instrument of attitudinal competencies in psychologists and psychology students (IAPE. 152 students and graduates of psychology were considered in the different phases of the study. Participants answered the IAPE and another two instruments to assess convergent and divergent validity. Results showed that the final instrument consist of 17 items has one-factor structure with adequate internal consistency. Furthermore, they showed the validity (convergent, divergent and discriminant of the instrument. Finally, it is discussed the usefulness of this instrument in the national context. At the same time it is been said that this is a preliminary study, being necessary futher researchs to conclude about IAPE validity.

  19. Melanoma inhibitor of apoptosis protein (ML-IAP) specific cytotoxic T lymphocytes cross-react with an epitope from the auto-antigen SS56

    DEFF Research Database (Denmark)

    Baek Sørensen, Rikke; Faurschou, Mikkel; Troelsen, Lone;

    2009-01-01

    A large proportion of melanoma patients host a spontaneous T-cell response specifically against ML-IAP-derived peptides. In this study, we describe that some ML-IAP-specific cytotoxic T cells isolated from melanoma patients cross react with an epitope from the auto-antigen SS56. SS56 is a recently...... described target of autoantibody responses in Sjögren's syndrome (SS) as well as systemic lupus erythematosus (SLE). Here, we describe that SS56 is also an auto-antigen for T cells in SS and SLE. Hence, SS56-specific T cells could readily be detected in circulation and among the infiltrating cells of SLE...... skin lesions. SS56-specific T cells were able to lyse target cells presenting the peptide epitope on the surface. Notably, SS56-specific CD8 T cells isolated from an SS patient cross reacted with the ML-IAP epitope. This early evidence of a target for auto-reactive CTL in SS and SLE patients...

  20. Design and Research of Picture Processing System Based on Web Requirement%基于web需求的图片处理系统设计研究

    Institute of Scientific and Technical Information of China (English)

    孙娜

    2015-01-01

    随着网络技术的发展,在资料交换和信息获取的过程中,图片资料占据了越来越大的比重,然而上传前图片的处理功能相对比较单一,无法满足人们未来发展的需求,越来越多的网络用户希望在图片上传过程中,借助web页面就可以对图片进行处理和修饰。因此本文将会对web页面图片处理系统设计与研究进行介绍,以实现图片处理的人性化,提升用户工作效率。%With the development of the network technology,picture information occupies an increasingly large pro-portion during data exchange and information acquisition. However,the picture processing functions before upload-ing are comparatively simple,which can′t meet the development requirement of people in the future. More and more network users want to process and decorate the pictures during the picture uploading period by virtue of the web page. Therefore,this paper introduces the design and research of the picture processing system on the web to real-ize the humanization during the picture processing period and improve the working efficiency of the users.

  1. User acceptance of a picture archiving and communication system (PACS in a Saudi Arabian hospital radiology department

    Directory of Open Access Journals (Sweden)

    Aldosari Bakheet

    2012-05-01

    Full Text Available Abstract Background Compared with the increasingly widespread use of picture archiving and communication systems (PACSs, knowledge concerning users’ acceptance of such systems is limited. Knowledge of acceptance is needed given the large (and growing financial investment associated with the implementation of PACSs, and because the level of user acceptance influences the degree to which the benefits of the systems for healthcare can be realized. Methods A Technology Acceptance Model (TAM was used to assess the level of acceptance of the host PACS by staff in the radiology department at King Abdulaziz Medical City (KAMC, Riyadh, Saudi Arabia. A questionnaire survey of 89 PACS users was employed to obtain data regarding user characteristics, perceived usefulness (PU (6 items, perceived ease of use (PEU (4 items, a change construct (4 items, and a behavior (acceptance construct (9 items. Respondents graded each item in each construct using five-point likert scales. Results Surveyed users reported high levels of PU (4.33/5, PEU (4.15/5, change (4.26/5, and acceptance (3.86/5. The three constructs of PU, PEU, and change explained 41 % of the variation in PACS user acceptance. PU was the most important predictor, explaining 38 % of the variation on its own. The most important single item in the explanatory constructs was that users found PACS to have improved the quality of their work in providing better patient care. Technologists had lower acceptance ratings than did clinicians/radiologists, but no influence on acceptance level was found due to gender, age, or length of experience using the PACS. Although not directly measured, there appeared to be no cultural influence on either the level of acceptance or its determinants. Conclusions User acceptance must be considered when an organization implements a PACS, in order to enhance its successful adoption. Health organizations should adopt a PACS that offers all required functions and which is

  2. Children with Autism Spectrum Disorder (ASD) Attend Typically to Faces and Objects Presented within Their Picture Communication Systems

    Science.gov (United States)

    Gillespie-Smith, K.; Riby, D. M.; Hancock, P. J. B.; Doherty-Sneddon, G.

    2014-01-01

    Background: Children with autism spectrum disorder (ASD) may require interventions for communication difficulties. One type of intervention is picture communication symbols which are proposed to improve comprehension of linguistic input for children with ASD. However, atypical attention to faces and objects is widely reported across the autism…

  3. Redirection of client/server relationship of X Window system as a simple, low-cost, departmental picture archiving and communication system solution for nuclear medicine.

    Science.gov (United States)

    Datz, F L; Baune, D A; Christian, P E

    1994-08-01

    Picture archiving and communication systems (PACS) offer significant advantages over current film-management techniques. However, PACS are complex and expensive, factors that have limited their entry into the radiology and nuclear medicine communities. We present a simple, low-cost PACS solution that allows viewing of images from different computer systems by redirection of the X Window system. In this technique, multiple copies of the imaging software are remotely opened from generic UNIX workstations interfaced to the main computer system via Transmission Control Protocol/Internet Protocol over Ethernet. The X Window system that provides the windowing system for the main computer is redirected to the workstations' displays. With this technique, viewing and processing of images on a remote station is virtually identical to working at the main computer's console. The technique requires that the commercial imaging system's hardware, operating system, and imaging software support multiuser multitasking and the execution of multiple copies of its imaging software, and that they use X Windows as the graphical system. Advantages of the technique include low cost, ease of maintenance, ease of interconnecting different types of computers, the capacity to view images regardless of file format, and the capacity to both view and process images. The latter is a necessity for modalities such as nuclear medicine. A disadvantage of the technique is that the number of nodes that can be supported is limited.

  4. Assessment of picture archiving and communication system (PACS) at three of ministry of health hospitals in Riyadh region - Content analysis.

    Science.gov (United States)

    Alalawi, Zainab M; Eid, Monief M; Albarrak, Ahmed I

    Picture archiving and communication system (PACS) are management information systems used for distributing, viewing and archiving digital images by integrating different types of modalities through communication networks. PACS have many advantages that can lead to improving health care quality. PACS has been widely used in hospitals in Saudi Arabia for the past 10 years. However, an extensive review of literature in the field of PACS, among physicians and radiologists in Saudi Arabia, showed lack of local studies of this costly and newly implemented technology. Therefore, this assessment is very important to provide an insightful study of PACS in Saudi Arabia to provide proper recommendations for the PACS projects implementation nationwide. The objectives of this study are to, firstly, assess the perceived benefits of PACS among physicians and radiologists specifically in quality of care, secondly, assess the perceived challenges of PACS implementation and adoption inside and outside the radiology department, and thirdly, to compare between physicians' and radiologists' perceptions toward PACS. A cross-sectional descriptive study at three of Ministry of Health (MOH) Hospitals in the Riyadh region, Saudi Arabia. The researchers used two separate surveys questionnaires, for administration to the physicians and radiologists at the three hospitals. Apart from the questionnaire, included is feedback as responses to open-ended questions. Content analysis was used to analyze the feedback under two themes: benefits or challenges. The response rate was 46% (84/183) physicians and 88% (15/17) radiologists have participated in this study. The result showed that 70% physicians' views affirms that PACS improved physicians' efficiency. On the other hand, all radiologists who responded affirmed that PACS improved efficiency. For questions on the ability to make decisions, 69% of views have affirmed that PACS improved physician's abilities to make decisions regarding patient care

  5. University of California San Francisco automated radiology department system-without picture archival and communication system (PACS)

    Science.gov (United States)

    Quintin, June A.; Simborg, Donald W.

    1982-01-01

    A fully automated and comprehensive Radiology Department system was implemented in the Fall of 1980, which highly integrates the multiple functions of a large Radiology Department in a major medical center. The major components include patient registration, film tracking, management statistics, patient flow control, radiologist reporting, pathology coding and billing. The highly integrated design allows sharing of critical files to reduce redundancy and errors in communication and allows rapid dissemination of information throughout the department. As one node of an integrated distributed hospital system, information from central hospital functions such as patient identification are incorporated into the system and reports and other information are available to other hospital systems. The system is implemented on a Data General Eclipse S/250 using the MIIS operating system. The management of a radiology department has become sufficiently complex that the application of computer techniques to the smooth operation of the department has become almost a necessity. This system provides statistics on room utilization, technologist productivity, and radiologist activity. Room utilization graphs are a valuable aid for staffing and scheduling of technologists, as well as analyzing appropriateness of radiologic equipment in a department. Daily reports summarize by radiology section exams not dictated. File room reports indicate which film borrowers are delinquent in returning films for 24 hours, 48 hours and one week. Letters to the offenders are automatically generated on the high speed line printer. Although all radiology departments have similar needs, customization is likely to be required to meet specific priorities and needs at any individual department. It is important in choosing a system vendor that such flexibility be available. If appropriately designed, a system will provide considerable improvements in efficiency and effectiveness.

  6. The Power of Pictures : Vertical Picture Angles in Power Pictures

    NARCIS (Netherlands)

    Giessner, Steffen R.; Ryan, Michelle K.; Schubert, Thomas W.; van Quaquebeke, Niels

    2011-01-01

    Conventional wisdom suggests that variations in vertical picture angle cause the subject to appear more powerful when depicted from below and less powerful when depicted from above. However, do the media actually use such associations to represent individual differences in power? We argue that the d

  7. Upregulation of cIAP2 in regenerating colonocytes in ulcerative colitis

    DEFF Research Database (Denmark)

    Seidelin, J.B.; Vainer, Ben; Andresen, L.

    2007-01-01

    It has been reported that colonocytes in ulcerative colitis (UC) upregulate anti-apoptotic cytoprotective pathways. An expression-profiling study of apoptosis-related genes suggested that the cellular inhibitor of apoptosis protein-2 (cIAP2) could be upregulated in epithelial cells in UC. The role...

  8. Functional analysis of two inhibitor of apoptosis (iap) orthologs from Helicoverpa armigera nucleopolyhedrovirus

    NARCIS (Netherlands)

    Liang, Ch.Y.; Lange, de J.; Chen, X.W.; Oers, van M.M.; Vlak, J.M.; Westenberg, M.

    2012-01-01

    Baculoviruses induce apoptotic responses in cultured insect cells, which can severely limit viral replication. To overcome this host response baculoviruses carry anti-apoptotic genes, including members of the p35 and inhibitor of apoptosis (iap) gene families. The baculovirus Helicoverpa armigera nu

  9. A comparative study of sustained attentional bias on emotional processing in ADHD children to pictures with eye-tracking.

    Science.gov (United States)

    Pishyareh, Ebrahim; Tehrani-Doost, Mehdi; Mahmoodi-Gharaie, Javad; Khorrami, Anahita; Rahmdar, Saeid Reza

    2015-01-01

    ADHD children have anomalous and negative behavior especially in emotionally related fields when compared to other. Evidence indicates that attention has an impact on emotional processing. The present study evaluates the effect of emotional processing on the sustained attention of children with ADHD type C. Sixty participants form two equal groups (each with 30 children) of normal and ADHD children) and each subject met the required selected criterion as either a normal or an ADHD child. Both groups were aged from 6-11-years-old. All pictures were chosen from the International Affective Picture System (IAPS) and presented paired emotional and neutral scenes in the following categories: pleasant-neutral; pleasant-unpleasant; unpleasant-neutral; and neutral-neutral. Sustained attention was evaluated based on the number and duration of total fixation and was compared between the groups with MANOVA analysis. The duration of sustained attention on pleasant in the pleasant-unpleasant pair was significant. Bias in duration of sustained attention on pleasant scenes in pleasant-neutral pairs is significantly different between the groups. Such significant differences might be indicative of ADHD children deficiencies in emotional processing. It seems that the highly deep effect of emotionally unpleasant scenes to gain the focus of ADHD children's attention is responsible for impulsiveness and abnormal processing of emotional stimuli.

  10. Inhibitors of apoptosis proteins (IAPs expression and their prognostic significance in hepatocellular carcinoma

    Directory of Open Access Journals (Sweden)

    Roncalli Massimo

    2009-04-01

    Full Text Available Abstract Background Similarly to other tumor types, an imbalance between unrestrained cell proliferation and impaired apoptosis appears to be a major unfavorable feature of hepatocellular carcinoma (HCC. The members of IAP family are key regulators of apoptosis, cytokinesis and signal transduction. IAP survival action is antagonized by specific binding of Smac/DIABLO and XAF1. This study aimed to investigate the gene and protein expression pattern of IAP family members and their antagonists in a series of human HCCs and to assess their clinical significance. Methods Relative quantification of IAPs and their antagonist genes was assessed by quantitative Real Time RT-PCR (qPCR in 80 patients who underwent surgical resection for HCC. The expression ratios of XIAP/XAF1 and of XIAP/Smac were also evaluated. Survivin, XIAP and XAF1 protein expression were investigated by immunohistochemistry. Correlations between mRNA levels, protein expression and clinicopathological features were assessed. Follow-up data were available for 69 HCC patients. The overall survival analysis was estimated according to the Kaplan-Meier method. Results Survivin and Livin/ML-IAP mRNAs were significantly over-expressed in cancer tissues compared to non-neoplastic counterparts. Although Survivin immunoreactivity did not correlate with qPCR data, a significant relation was found between higher Survivin mRNA level and tumor stage, tumor grade and vascular invasion. The mRNA ratio XIAP/XAF1 was significantly higher in HCCs than in cirrhotic tissues. Moreover, high XIAP/XAF1 ratio was an indicator of poor prognosis when overall survival was estimated and elevated XIAP immunoreactivity was significantly associated with shorter survival. Conclusion Our study demonstrates that alterations in the expression of IAP family members, including Survivin and Livin/ML-IAP, are frequent in HCCs. Of interest, we could determine that an imbalance in XIAP/XAF1 mRNA expression levels correlated

  11. Adoption of alternative financing strategies to increase the diffusion of picture archiving and communication systems into the radiology marketplace.

    Science.gov (United States)

    Reiner, B; Siegel, E; McKay, P

    2000-05-01

    The objective of the study was to evaluate current marketplace conditions and strategies employed by major picture archiving and communication systems (PACS) vendors in the creation of alternative financing strategies, to enhance the diffusion of filmless imaging. Data were collected from the major PACS vendors in the forms of survey questionnaires and review of existing leases. Topics evaluated in the survey included current financing options available, foreseeable changes in PACS financing, role of third-party financiers, and creation of risk-sharing arrangements. Generic leases were also reviewed evaluating the presence or absence of several key variables including technology obsolescence protection, hardware/software upgrades, end-of-term options, determination of fair market value, functionality/acceptance testing, uptime guarantees, and workflow management consulting. Eight of the 10 PACS vendors surveyed participated in the data collection. The vast majority of current PACS implementations (60% to 90%) occur through direct purchase, with conventional leasing (operating or capital) accounting for only 5% to 30% of PACS installations. The majority of respondents view fee-for-lease arrangements and other forms of risk sharing as increasing importance for future PACS financing. The specific targets for such risk-sharing arrangements consist of small hospital and privately owned imaging centers. Leases currently offered range in duration from 3 to 5 years and frequently offer technology obsolescence protection with upgrades, multiple end-of-term options, and some form of acceptance testing. A number of important variables frequently omitted from leases include uptime guarantees, flexibility in changing financing or vendors, and incorporation of expected productivity/operational efficiency gains. As vendors strive to increase the penetration of PACS into the radiology marketplace, there will be a shift from conventional financing (loan or purchase) to leasing. Fee

  12. Filmless in 60 days: the impact of picture archiving and communications systems within a large urban hospital.

    Science.gov (United States)

    Hayt, D B; Alexander, S; Drakakis, J; Berdebes, N

    2001-06-01

    Many large urban hospitals converting to filmless radiography use a phased approach for digital imaging implementation. In fact, this strategy often is recommended by picture archival communication systems (PACS) experts and vendors alike for large, busy hospitals installing PACS in existing physical facilities. The concern is that comprehensive conversion from film-based to digital imaging may be too overwhelming an adjustment in operations for a medical staff to effectively handle without serious disruption of workflow for patient treatment and care. Elmhurst Hospital Center is a 543-bed hospital located in the Borough of Queens in New York City. Owned by the New York City Health and Hospitals Corporation, this municipal teaching hospital provides services to a patient mix that is 38% indigent with no insurance, 50% covered by Medicaid or Medicare, and 12% affiliated with HMOs. Most inpatients are admitted through the emergency department. Forty-five percent of all radiology procedures conducted are for emergency patients. Historically, up to 25% of all diagnostic imaging examinations were never reported formally by radiologists. Report turnaround time for the remaining 75% was unacceptable, with only 3% of all imaging examinations reported within a 12-hour period in 1996. Both situations existed in great part because physicians and residents who felt they needed access to films simply took them. Many were never located or returned days after they were taken. In 1998, Elmhurst Hospital Center replaced its RIS and added voice recognition dictation capabilities in January 1999. A hospitalwide PACS was deployed 10 months later. With the exception of mammography, the hospital converted to filmless radiography within 60 days. The critical objectives to maintain control of films and radically improve the reporting process were achieved immediately. Over 99% of all examinations now are formally reviewed and reported. Only 7% of all reports take 1 or more days to

  13. Study of Picture Archiving and Communications System for application of orbital disease%眼眶病变中PACS图像系统的应用

    Institute of Scientific and Technical Information of China (English)

    韩晓晖; 施明光

    2009-01-01

    目的 探讨眼眶病变中PACS图像系统的诊断价值.方法 对70例眼眶病变患者行眼眶CT检查,部分行MRI,DSA检查.结果 在70例眼眶疾病中眼眶骨折38例,海绵状血管瘤4例,皮样囊肿3例,眼眶异物2例,其他23例.PACS图像系统能有效提高诊断率.结论 PACS图像系统在眼眶病变中的诊断中具有重要价值,并能指导手术方案的设计.%Objective To study of Picture Archiving and Communications System for application in orbital disease.Methods Picture Archiving and Communications System was performed on orbital disease of 70 cases.Results The orbital disease included blow-out fracture in 70 cases,blow-out fracture 38 cases,venous angioma 4 cases,dermoid cyst 3 cases,orbital foreign body 2 case and others 14 cases.Conclusions Picture Archiving and Communications System can provide accurate diagnosis for orbital disease and instruct operate scheme.

  14. Children with autism spectrum disorder (ASD) attend typically to faces and objects presented within their picture communication systems.

    Science.gov (United States)

    Gillespie-Smith, K; Riby, D M; Hancock, P J B; Doherty-Sneddon, G

    2014-05-01

    Children with autism spectrum disorder (ASD) may require interventions for communication difficulties. One type of intervention is picture communication symbols which are proposed to improve comprehension of linguistic input for children with ASD. However, atypical attention to faces and objects is widely reported across the autism spectrum for several types of stimuli. In this study we used eye-tracking methodology to explore fixation duration and time taken to fixate on the object and face areas within picture communication symbols. Twenty-one children with ASD were compared with typically developing matched groups. Children with ASD were shown to have similar fixation patterns on face and object areas compared with typically developing matched groups. It is proposed that children with ASD attend to the images in a manner that does not differentiate them from typically developing individuals. Therefore children with and without autism have the same opportunity to encode the available information. We discuss what this may imply for interventions using picture symbols. © 2013 The Authors. Journal of Intellectual Disability Research © 2013 John Wiley & Sons Ltd, MENCAP & IASSIDD.

  15. BCL-XL regulates TNF-α-mediated cell death independently of NF-кB,FLIP and IAPs

    Institute of Scientific and Technical Information of China (English)

    Raffaella Gozzelino; Nahuai Badiola; Daniel Sanchis; Jose Rodriguez-Alvarez; Ramon Trullas; Victor J Yuste; Joan X Comella; Carme Sole; Nuria Llecha; Miguel F Segura; Rana S Moubarak; Victoria Iglesias-Guima-rais; M Jose Perez-Garcia; Stephanie Reix; Jisheng Zhang

    2008-01-01

    Upon activation,tumor necrosis factor alpha (TNF-α) receptor can engage apoptotic or survival pathways.Inhibition of macromolecular synthesis is known to sensitize cells to TNF-α-induced cell death.It is believed that this sensitization is due to the transcriptional blockade of genes regulated by NF-κB.Nevertheless,such evidence has remained elusive in the nervous system.Here,we show that TNF-α cannot normally induce apoptosis in PC12 cells or cortical neurons.However,cells treated with Actinomycin D (ActD) become susceptible to TNF-α-induced cell death through the activation of caspase-8,generation of tBid and activation of caspase-9 and -3.Analysis of several proteins involved in TNF-α receptor signaling showed no significant downregulation of NF-κB target genes,such as IAPs or FLIP,under such conditions.However,Bcl-xL protein levels,but not those of Bcl-2,Bax and Bak,are reduced by ActD or TNF-α/ActD treatments.Moreover,Bcl-xL overexpression fully protects cells against TNF-α/ActD-induced cell death.When endogenous levels of Bcl-XL are specifically downregulated by ientiviral-based RNAi,cells no longer require ActD to be sensitive to TNF-α-triggered apoptosis.Furthermore,Bcl-xL downregulation does not affect TNF-α-mediated NF-κB activation.Altogether,our results demonstrate that Bcl-xL,and not Bcl-2,FLIP or IAPs,acts as the endogenous regulator of neuronal resistance/sensitivity to TNF-α-induced apoptosis in an NF-KB-independent manner.

  16. Space perception in pictures

    NARCIS (Netherlands)

    Van Doorn, A.J.; Wagemans, J.; De Ridder, H.; Koenderink, J.J.

    2011-01-01

    A "picture" is a at object covered with pigments in a certain pattern. Human observers, when looking "into" a picture (photograph, painting, drawing, . . . say) often report to experience a three dimensional "pictorial space." This space is a mental entity, apparently triggered by so called pictori

  17. Enhancement of TRAIL cytotoxicity by AG-490 in human ALL cells is characterized by downregulation of cIAP-1 and cIAP-2 through inhibition of Jak2/Stat3

    Institute of Scientific and Technical Information of China (English)

    Paola Lanuti; Valeria Bertagnolo; Laura Pierdomenico; Adriana Bascelli; Eugenio Santavenere; Lapo Alinari; Silvano Capitani; Sebastiano Miscia; Marco Marchisio

    2009-01-01

    The ability of death-inducing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to selectively kill a variety of cancer cells has been largely described, but one of the major concerns with the treatment is the occur-rence of drug resistance and possible toxic side effects. Here, we report that TRAIL induces apoptosis in Jurkat and SUPT1 T cell lines and in human T-ALL blasts but not in healthy subject-derived peripheral blood mononuclear cells. In parallel, the treatment with TRAIL and Tyrphostin (AG-490), a selective Janus kinase 2 inhibitor, produces an evident enhancement of cytotoxicity, characterized by a significant inhibition of Stat3 phosphorylation compared to controls or to TRAIL alone-treated samples, and associated with a dramatic decrease of both cIAP-1 and cIAP-2 mRNA levels. Downregulation of cIAP-1 and cIAP-2 by specific small interference RNAs significantly amplifies TRAIL-reduced cytotoxicity. All together, these findings strongly indicate that cIAP-1 and cIAP-2 downregulation is a fundamental step in the signaling pathways mediating the combinatorial effect of TRAIL and AG-490 on T cell leu-kemia. These findings may help to open new routes for the development of less toxic pharmacological strategies in the treatment of patients affected by TRAIL-sensitive leukemias.

  18. Topically Applied AaeIAP1 Double-Stranded RNA Kills Female Adults of Aedes aegypti

    Science.gov (United States)

    2008-05-01

    without dsRNA treatment). DNA Fragmentation Assay. Thirty adult female mosquitoeswere treatedwithorwithoutdsRNAprod- uctsbyusingacetoneascarrier...andmaintainedat 26C and 80% RH, respectively. Twenty-four hours post- treatment, mosquitoes were placed on dry ice and then harvested to assay DNA fragmentation , one...tion of apoptosis were shown in Fig. 2. The DNA fragmentationwas obvious inmosquitoes treatedwith AaeIAP1 dsRNA. In contrast, DNA fragmentation ef

  19. Neisseria gonorrhoeae Modulates Cell Death in Human Endocervical Epithelial Cells through Export of Exosome-Associated cIAP2.

    Science.gov (United States)

    Nudel, Kathleen; Massari, Paola; Genco, Caroline A

    2015-09-01

    Several bacterial pathogens persist and survive in the host by modulating host cell death pathways. We previously demonstrated that Neisseria gonorrhoeae, a Gram-negative pathogen responsible for the sexually transmitted infection gonorrhea, protects against exogenous induction of apoptosis in human cervical epithelial cells. However, induction of cell death by N. gonorrhoeae has also been reported in other cell types. The mechanisms by which N. gonorrhoeae modulates cell death are not clear, although a role for the inhibitor of apoptosis-2 (cIAP2) has been proposed. In this study, we confirmed that N. gonorrhoeae induces production of cIAP2 in human cervical epithelial cells. High levels of intracellular cIAP2 were detected early after N. gonorrhoeae stimulation, which was followed by a marked decrease at 24 h. At this time point, we observed increased levels of extracellular cIAP2 associated with exosomes and an overall increase in production of exosomes. Inhibition of cIAP2 in N. gonorrhoeae-stimulated epithelial cells resulted in increased cell death and interleukin-1β (IL-1β) production. Collectively these results indicate that N. gonorrhoeae stimulation of human endocervical epithelial cells induces the release of cIAP2, an essential regulator of cell death and immune signaling.

  20. A comparison between digital images viewed on a picture archiving and communication system diagnostic workstation and on a PC-based remote viewing system by emergency physicians.

    Science.gov (United States)

    Parasyn, A; Hanson, R M; Peat, J K; De Silva, M

    1998-02-01

    Picture Archiving and Communication Systems (PACS) make possible the viewing of radiographic images on computer workstations located where clinical care is delivered. By the nature of their work this feature is particularly useful for emergency physicians who view radiographic studies for information and use them to explain results to patients and their families. However, the high cost of PACS diagnostic workstations with fuller functionality places limits on the number of and therefore the accessibility to workstations in the emergency department. This study was undertaken to establish how well less expensive personal computer-based workstations would work to support these needs of emergency physicians. The study compared the outcome of observations by 5 emergency physicians on a series of radiographic studies containing subtle abnormalities displayed on both a PACS diagnostic workstation and on a PC-based workstation. The 73 digitized radiographic studies were randomly arranged on both types of workstation over four separate viewing sessions for each emergency physician. There was no statistical difference between a PACS diagnostic workstation and a PC-based workstation in this trial. The mean correct ratings were 59% on the PACS diagnostic workstations and 61% on the PC-based workstations. These findings also emphasize the need for prompt reporting by a radiologist.

  1. Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription.

    Science.gov (United States)

    Cartier, Jessy; Berthelet, Jean; Marivin, Arthur; Gemble, Simon; Edmond, Valérie; Plenchette, Stéphanie; Lagrange, Brice; Hammann, Arlette; Dupoux, Alban; Delva, Laurent; Eymin, Béatrice; Solary, Eric; Dubrez, Laurence

    2011-07-29

    The inhibitor of apoptosis protein cIAP1 (cellular inhibitor of apoptosis protein-1) is a potent regulator of the tumor necrosis factor (TNF) receptor family and NF-κB signaling pathways in the cytoplasm. However, in some primary cells and tumor cell lines, cIAP1 is expressed in the nucleus, and its nuclear function remains poorly understood. Here, we show that the N-terminal part of cIAP1 directly interacts with the DNA binding domain of the E2F1 transcription factor. cIAP1 dramatically increases the transcriptional activity of E2F1 on synthetic and CCNE promoters. This function is not conserved for cIAP2 and XIAP, which are cytoplasmic proteins. Chromatin immunoprecipitation experiments demonstrate that cIAP1 is recruited on E2F binding sites of the CCNE and CCNA promoters in a cell cycle- and differentiation-dependent manner. cIAP1 silencing inhibits E2F1 DNA binding and E2F1-mediated transcriptional activation of the CCNE gene. In cells that express a nuclear cIAP1 such as HeLa, THP1 cells and primary human mammary epithelial cells, down-regulation of cIAP1 inhibits cyclin E and A expression and cell proliferation. We conclude that one of the functions of cIAP1 when localized in the nucleus is to regulate E2F1 transcriptional activity.

  2. Picturing the Heart

    Science.gov (United States)

    ... Links for Students Glossary Picturing the Heart SCIENCE EDUCATION Science Topics Resource Links for General Public Resource Links for Parents/Teachers Resource Links for Students Glossary Government Resources Kids.gov – Science Information and services on the web ...

  3. Vision and Motion Pictures.

    Science.gov (United States)

    Grambo, Gregory

    1998-01-01

    Presents activities on persistence of vision that involve students in a hands-on approach to the study of early methods of creating motion pictures. Students construct flip books, a Zoetrope, and an early movie machine. (DDR)

  4. Yangliuqing New Year Pictures

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    HANGING up New Yearpictures during khe SpringFestival to symbolize goodluck in the coming year has longbeen a tradition in China,The pic-tures are both colorful and jubilantin theme and composition so as toattract everything good in the com-ing year and drive away evil.Four main“schools” of folk artdealing with New Year pictures ex-ist.Among the best known is thewoodblocK print from Yangliuqing,

  5. c-IAP1在食管鳞癌中的表达及其对化疗敏感性的影响%c-IAP1 expression and tumor chemosensitivity in esophageal squamous cell carcinoma

    Institute of Scientific and Technical Information of China (English)

    许杨; 刘芳; 周兰萍; 赵晓航

    2011-01-01

    目的:探讨食管鳞癌细胞凋亡抑制蛋白1(c-IAP1)表达与化疗敏感性的相关性.方法:食管鳞癌组织芯片免疫组织化学染色,分析食管鳞癌组织及其配对癌旁食管上皮中c-IAP1的表达和定位及其与肿瘤,临床分级的关系.免疫印迹分析食管癌细胞C-IAP1和Smac表达,用RNA干扰技术敲降Smac表达,MTT法检测细胞对化疗药物敏感性的影响.统计分析采用卡方检验.结果:与癌旁食管上皮(54%,28/52)相比,c-IAP1在食管癌组织中高表达(67%,35/52),但与肿瘤病理分级、年龄和}生别无关.c-IAP1定位于组织细胞质和细胞核,在46%(24/52)的肿瘤组织中,细胞质c-IAP1表达水平显著高于配对癌旁食管上皮4%(2/52),具有统计学意义(P<0.001).食管癌EC0156、KYSE510、KYSE30、KYSE1 80和KYSE170细胞普遍表达c-IAP1,其中KYSE170细胞表达最高.经RNA干扰敲降Smac分子,可显著降低KYSE170细胞对化疗药物的敏感性.结论:c-IAP1蛋白在食管癌组织细胞质中表达率高,经化疗药物处理后,Smac介导c-IAP1降解,增加了食管癌细胞对化疗药物的敏感性,c-IAP1在调控食管癌化疗敏感性中发挥重要作用.%AIM: To investigate the expression of cellular inhibitor of apoptosis protein 1 (c-IAP1) in esophageal squamous cell carcinoma (ESCC) and to evaluate the correlation between c-IAP1 expression and chemosensitivity of ESCC cell lines.METHODS: Immunohistochemistry staining was performed to determine the expression of c-IAP1 in ESCC on tissue microarray.The chisquare test was used to analyze the correlation between c-IAP1 expression and clinicopathologic parameters of ESCC.The expression of c-IAP1and Smac in several ESCC cell lines was detected by Western blot.The chemosensitivity of ESCC cell lines was evaluated by RNA interference with Smac gene expression and MTT assay.RESULTS: c-IAP1 expression was found in 67%(35/52) of ESCC tissue specimens and in 54%(28/52) of tumor-adjacent normal tissue

  6. Virtual reality system for treatment of the fear of public speaking using image-based rendering and moving pictures.

    Science.gov (United States)

    Lee, Jae M; Ku, Jeong H; Jang, Dong P; Kim, Dong H; Choi, Young H; Kim, In Y; Kim, Sun I

    2002-06-01

    The fear of speaking is often cited as the world's most common social phobia. The rapid growth of computer technology enabled us to use virtual reality (VR) for the treatment of the fear of public speaking. There have been two techniques used to construct a virtual environment for the treatment of the fear of public speaking: model-based and movie-based. Virtual audiences and virtual environments made by model-based technique are unrealistic and unnatural. The movie-based technique has a disadvantage in that each virtual audience cannot be controlled respectively, because all virtual audiences are included in one moving picture file. To address this disadvantage, this paper presents a virtual environment made by using image-based rendering (IBR) and chroma keying simultaneously. IBR enables us to make the virtual environment realistic because the images are stitched panoramically with the photos taken from a digital camera. And the use of chroma keying allows a virtual audience to be controlled individually. In addition, a real-time capture technique was applied in constructing the virtual environment to give the subjects more interaction, in that they can talk with a therapist or another subject.

  7. IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis

    DEFF Research Database (Denmark)

    Gyrd-Hansen, Mads; Darding, Maurice; Miasari, Maria

    2008-01-01

    The covalent attachment of ubiquitin to target proteins influences various cellular processes, including DNA repair, NF-kappaB signalling and cell survival. The most common mode of regulation by ubiquitin-conjugation involves specialized ubiquitin-binding proteins that bind to ubiquitylated...... found that the UBA domain is essential for the oncogenic potential of cIAP1, to maintain endothelial cell survival and to protect cells from TNF-alpha-induced apoptosis. Moreover, the UBA domain is required for XIAP and cIAP2-MALT1 to activate NF-kappaB. Our data suggest that the UBA domain of cIAP2......-MALT1 stimulates NF-kappaB signalling by binding to polyubiquitylated NEMO. Significantly, 98% of all cIAP2-MALT1 fusion proteins retain the UBA domain, suggesting that ubiquitin-binding contributes to the oncogenic potential of cIAP2-MALT1 in MALT lymphoma. Our data identify IAPs as ubiquitin...

  8. Picture Exchange Communication System and Pals: A Peer-Mediated Augmentative and Alternative Communication Intervention for Minimally Verbal Preschoolers With Autism.

    Science.gov (United States)

    Thiemann-Bourque, Kathy; Brady, Nancy; McGuff, Sara; Stump, Keenan; Naylor, Amy

    2016-10-01

    This study was conducted to investigate the effectiveness of a social intervention that integrates peer-mediated approaches and the Picture Exchange Communication System (PECS). Effects were evaluated using a series of A-B designs replicated across 4 children with severe autism and limited verbal skills. Seven peers without disabilities were trained to use PECS and facilitative social skills. Measures of changes included rates of communication behaviors, modes, functions, and engagement. Outcomes revealed an intervention effect for 1 child with autism, and this effect was replicated across 3 other children. All children improved in peer-directed communication, with greater increases for 2 children during snack time. For each child with autism, the primary communication behavior was to initiate with picture symbols to request; the peer's primary communication was to respond. Two children increased communicative functions to comment and to share, and all 4 children showed improved social engagement. All peers increased their communication with the children with autism. These findings add to the limited research on the benefits of teaching typically developing peers to be responsive listeners to preschoolers with autism by learning to use PECS. These results invite further investigation of teaching peers other augmentative and alternative communication approaches and how to increase children's communication with peers for different purposes.

  9. Nxf1 natural variant E610G is a semi-dominant suppressor of IAP-induced RNA processing defects.

    Directory of Open Access Journals (Sweden)

    Dorothy Concepcion

    2015-04-01

    Full Text Available Endogenous retroviruses and retrotransposons contribute functional genetic variation in animal genomes. In mice, Intracisternal A Particles (IAPs are a frequent source of both new mutations and polymorphism across laboratory strains. Intronic IAPs can induce alternative RNA processing choices, including alternative splicing. We previously showed IAP I∆1 subfamily insertional mutations are suppressed by a wild-derived allele of the major mRNA export factor, Nxf1. Here we show that a wider diversity of IAP insertions present in the mouse reference sequence induce insertion-dependent alternative processing that is suppressed by Nxf1CAST alleles. These insertions typically show more modest gene expression changes than de novo mutations, suggesting selection or attenuation. Genome-wide splicing-sensitive microarrays and gene-focused assays confirm specificity of Nxf1 genetic modifier activity for IAP insertion alleles. Strikingly, CRISPR/Cas9-mediated genome editing demonstrates that a single amino acid substitution in Nxf1, E610G, is sufficient to recreate a quantitative genetic modifier in a co-isogenic background.

  10. IAP-Based Cell Sorting Results in Homogeneous Transplantable Dopaminergic Precursor Cells Derived from Human Pluripotent Stem Cells.

    Science.gov (United States)

    Lehnen, Daniela; Barral, Serena; Cardoso, Tiago; Grealish, Shane; Heuer, Andreas; Smiyakin, Andrej; Kirkeby, Agnete; Kollet, Jutta; Cremer, Harold; Parmar, Malin; Bosio, Andreas; Knöbel, Sebastian

    2017-09-19

    Human pluripotent stem cell (hPSC)-derived mesencephalic dopaminergic (mesDA) neurons can relieve motor deficits in animal models of Parkinson's disease (PD). Clinical translation of differentiation protocols requires standardization of production procedures, and surface-marker-based cell sorting is considered instrumental for reproducible generation of defined cell products. Here, we demonstrate that integrin-associated protein (IAP) is a cell surface marker suitable for enrichment of hPSC-derived mesDA progenitor cells. Immunomagnetically sorted IAP(+) mesDA progenitors showed increased expression of ventral midbrain floor plate markers, lacked expression of pluripotency markers, and differentiated into mature dopaminergic (DA) neurons in vitro. Intrastriatal transplantation of IAP(+) cells sorted at day 16 of differentiation in a rat model of PD resulted in functional recovery. Grafts from sorted IAP(+) mesDA progenitors were more homogeneous in size and DA neuron density. Thus, we suggest IAP-based sorting for reproducible prospective enrichment of mesDA progenitor cells in clinical cell replacement strategies. Copyright © 2017 Miltenyi Biotec GmbH. Published by Elsevier Inc. All rights reserved.

  11. Nxf1 natural variant E610G is a semi-dominant suppressor of IAP-induced RNA processing defects.

    Directory of Open Access Journals (Sweden)

    Dorothy Concepcion

    2015-04-01

    Full Text Available Endogenous retroviruses and retrotransposons contribute functional genetic variation in animal genomes. In mice, Intracisternal A Particles (IAPs are a frequent source of both new mutations and polymorphism across laboratory strains. Intronic IAPs can induce alternative RNA processing choices, including alternative splicing. We previously showed IAP I∆1 subfamily insertional mutations are suppressed by a wild-derived allele of the major mRNA export factor, Nxf1. Here we show that a wider diversity of IAP insertions present in the mouse reference sequence induce insertion-dependent alternative processing that is suppressed by Nxf1CAST alleles. These insertions typically show more modest gene expression changes than de novo mutations, suggesting selection or attenuation. Genome-wide splicing-sensitive microarrays and gene-focused assays confirm specificity of Nxf1 genetic modifier activity for IAP insertion alleles. Strikingly, CRISPR/Cas9-mediated genome editing demonstrates that a single amino acid substitution in Nxf1, E610G, is sufficient to recreate a quantitative genetic modifier in a co-isogenic background.

  12. Comparative efficacy of the picture exchange communication system (PECS) versus a speech-generating device: effects on social-communicative skills and speech development.

    Science.gov (United States)

    Boesch, Miriam C; Wendt, Oliver; Subramanian, Anu; Hsu, Ning

    2013-09-01

    The Picture Exchange Communication System (PECS) and a speech-generating device (SGD) were compared in a study with a multiple baseline, alternating treatment design. The effectiveness of these methods in increasing social-communicative behavior and natural speech production were assessed with three elementary school-aged children with severe autism who demonstrated extremely limited functional communication skills. Results for social-communicative behavior were mixed for all participants in both treatment conditions. Relatively little difference was observed between PECS and SGD conditions. Although findings were inconclusive, data patterns suggest that Phase II of the PECS training protocol is conducive to encouraging social-communicative behavior. Data for speech outcomes did not reveal any increases across participants, and no differences between treatment conditions were observed.

  13. Evaluation of Picture Archiving and Communication System (Pacs As A Process Improvement Sample (Sivas Numune Hospital Application

    Directory of Open Access Journals (Sweden)

    Ali Rıza İnce

    2013-09-01

    Full Text Available It is a realitythatthefirmsproducinggoods or services frequentlybenefited process improvementand similartechniques toachieve their objectives In today'scompetitive environment.Beingprocess-orientedmeans to give weight to the creation of quality but not to the control of quality. In this sense, process improvement is seen as an approach of Total Quality Management targeted. Hospital informationsystems are computer systems that collect andarchive all orthe majority of the hospitaldatafor use inthe assessment.It isa major problem that storage of visualdatawithout lossanddamage and also the being availableof these data as soon as possiblein this system.System that calledPACShas been developedto overcome this problem.PACS is an archiving system that archive the visual dataobtained fromimaging systems in different unitsin a spaceand, allows the transfer of these data to usersat different points when needed.In this study,efficiency of PACS asa process improvementtechniquewas examined by the application ofahospital.It is concluded that the system providea positive contributionto customers and hospitalas an example ofan importantprocess improvement at the evaluationof the results and implementation of the system.

  14. Molecular analysis of the iap gene of Listeria monocytogenes isolated from cheeses in Rio Grande do Sul, Brazil Análise molecular do gene iap de Listeria monocytogenes isoladas de queijos no Estado do Rio Grande do Sul, Brasil

    Directory of Open Access Journals (Sweden)

    Jozi Fagundes de Mello

    2008-03-01

    Full Text Available The polymorphic region sequences in the iap gene were analyzed in 25 strains of Listeria monocytogenes isolated from cheeses in the state of Rio Grande do Sul, and compared with reference strains. This investigation distinguished two clusters of L. monocytogenes: I (20 strains and II (5 strains.A seqüência da região polimórfica do gene iap foi analisada em 25 cepas de Listeria monocytogenes isoladas de queijo no Estado do Rio Grande do Sul e comparadas com cepas referências. Esta investigação distinguiu L. monocytogenes em dois grupos: I (20 cepas e II (5 cepas.

  15. The inhibitor of apoptosis protein fusion c-IAP2.MALT1 stimulates NF-kappaB activation independently of TRAF1 AND TRAF2.

    Science.gov (United States)

    Varfolomeev, Eugene; Wayson, Sarah M; Dixit, Vishva M; Fairbrother, Wayne J; Vucic, Domagoj

    2006-09-29

    The inhibitors of apoptosis (IAPs) are a family of cell death inhibitors found in viruses and metazoans. All members of the IAP family have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity. The t(11, 18)(q21;q21) translocation fuses the BIR domains of c-IAP2 with the paracaspase/MALT1 (mucosa-associated lymphoid tissue) protein, a critical mediator of T cell receptor-stimulated activation of NF-kappaB. The c-IAP2.MALT1 fusion protein constitutively activates the NF-kappaB pathway, and this is considered critical to malignant B cell transformation and lymphoma progression. The BIR domains of c-IAP1 and c-IAP2 interact with tumor necrosis factor receptor-associated factors 1 and 2 (TRAF1 and TRAF2). Here we investigated the importance of TRAF1 and TRAF2 for c-IAP2.MALT1-stimulated NF-kappaB activation. We identified a novel epitope within the BIR1 domains of c-IAP1 and c-IAP2 that is crucial for their physical interaction with TRAF1 and TRAF2. The c-IAP2.MALT1 fusion protein associates with TRAF1 and TRAF2 using the same binding site. We explored the functional relevance of this interaction and established that binding to TRAF1 and TRAF2 is not required for c-IAP2.MALT1-stimulated NF-kappaB activation. Furthermore, gene ablation of TRAF2 or combined down-regulation of TRAF1 and TRAF2 did not affect c-IAP2.MALT1-stimulated signaling. However, TRAF1/2-binding mutants of c-IAP2.MALT1 still oligomerize and activate NF-kappaB, suggesting that oligomerization might be important for signaling of the fusion protein. Therefore, the t(11, 18)(q21;q21) translocation creating the c-IAP2.MALT1 fusion protein activates NF-kappaB and contributes to human malignancy in the absence of signaling adaptors that might otherwise regulate its activity.

  16. TRAF2-binding BIR1 domain of c-IAP2/MALT1 fusion protein is essential for activation of NF-kappaB.

    Science.gov (United States)

    Garrison, J B; Samuel, T; Reed, J C

    2009-04-02

    Marginal zone mucosa-associated lymphoid tissue (MALT) B-cell lymphoma is the most common extranodal non-Hodgkin lymphoma. The t(11;18)(q21;q21) translocation occurs frequently in MALT lymphomas and creates a chimeric NF-kappaB-activating protein containing the baculoviral IAP repeat (BIR) domains of c-IAP2 (inhibitor of apoptosis protein 2) fused with portions of the MALT1 protein. The BIR1 domain of c-IAP2 interacts directly with TRAF2 (TNFalpha-receptor-associated factor-2), but its role in NF-kappaB activation is still unclear. Here, we investigated the role of TRAF2 in c-IAP2/MALT1-induced NF-kappaB activation. We show the BIR1 domain of c-IAP2 is essential for NF-kappaB activation, whereas BIR2 and BIR3 domains are not. Studies of c-IAP2/MALT1 BIR1 mutant (E47A/R48A) that fails to activate NF-kappaB showed loss of TRAF2 binding, but retention of TRAF6 binding, suggesting that interaction of c-IAP2/MALT1 with TRAF6 is insufficient for NF-kappaB induction. In addition, a dominant-negative TRAF2 mutant or downregulation of TRAF2 achieved by small interfering RNA inhibited NF-kappaB activation by c-IAP2/MALT1 showing that TRAF2 is indispensable. Comparisons of the bioactivity of intact c-IAP2/MALT1 oncoprotein and BIR1 E47A/R48A c-IAP2/MALT1 mutant that cannot bind TRAF2 in a lymphoid cell line provided evidence that TRAF2 interaction is critical for c-IAP2/MALT1-mediated increases in the NF-kappaB activity, increased expression of endogenous NF-kappaB target genes (c-FLIP, TRAF1), and resistance to apoptosis.

  17. Adoption and resistance: reflections on human, organizational, and information technologies in picture archive and communication systems (PACS)

    Science.gov (United States)

    Sappington, Rodney W.

    2005-04-01

    In research conducted at academic and community hospitals in the United States since 2001, this paper examines complex human and technological relationships employed to renegotiate behavior within hospital administrative and clinical cultures. In the planning and implementation of PACS in a four-facility hospital we will enter into what can be described as processes of "adoption" and "resistance", seemingly opposite approaches to system implementation, which I argue are in fact key responses to planning, design, and customization of imaging and information systems in a context of convergence. In a larger context of convergence known as NBIC tools (nanotechnology, biotechnology, information technology, and cognitive sciences) it has become increasingly clear to leaders in the field that it is essential to redesign organizational technologies. A novel system has little chance of being fully utilized by conventional organizational structures in an era of system convergence. The challenge of embracing a larger systems perspective lies in opening untapped potential within the healthcare enterprise by preparing the ground for reflection on new approaches to training, and bridging specialized knowledge across computer engineering, clinical decision making, and organizational perspectives for the benefit of patient care. Case studies will demonstrate how organizational and system design technologies are crucial in insuring that PACS implementation strategies can encourage the emergence of new levels of quality for patient care. The goal is to provide successful design-build models that are true to organizational specificity, persons, and clinical practices undergoing change and uncertainty.

  18. Psychophysical Evaluation Of The Spatial And Contrast Resolution Necessary For A Picture Archiving And Communication System: Works In Progress

    Science.gov (United States)

    Fisher, H. D.; Seeley, G. W.; Bjelland, J. C.; Ovitt, T. W.; Capp, M. P.

    1984-08-01

    The Radiology Department of the University of Arizona Health Sciences Center is involved in a five year project to develop a prototype for a Totally Digital Radiology Department (TDRD). One prerequisite for such a department is that the system must allow the radiologist to perform at the same level as with the existing film-based system. The amount of spatial and contrast resolution required to equal the diagnostic information in films will impact directly on the capabilities of the equipment needed to image, transmit, display, and store such images. This is a crucial question that must be addressed because of its diagnostic import and due to its engineering implications.

  19. Development and validation of a visual body condition scoring system for dairy goats with picture-based training.

    Science.gov (United States)

    Vieira, A; Brandão, S; Monteiro, A; Ajuda, I; Stilwell, G

    2015-09-01

    Body condition scoring (BCS) is the most widely used method to assess changes in body fat reserves, which reflects its high potential to be included in on-farm welfare assessment protocols. Currently used scoring systems in dairy goats require animal restraint for body palpation. In this study, the Animal Welfare Indicators project (AWIN) proposes to overcome this constraint by developing a scoring system based only on visual assessment. The AWIN visual body condition scoring system highlights representative animals from 3 categories: very thin, normal, and very fat, and was built from data sets with photographs of animals scored by a commonly used 6-point scoring system that requires palpation in 2 anatomical regions. Development of the AWIN scoring system required 3 steps: (1) identification and validation of a body region of interest; (2) sketching the region from photographs; and (3) creation of training material. The scoring system's reliability was statistically confirmed. An initial study identified features in the rump region from which we could compute a set of body measurements (i.e., measures based on anatomical references of the rump region) that showed a strong correlation with the assigned BCS. To validate the result, we collected a final data set from 171 goats. To account for variability in animal size and camera position, we mapped a subset of features to a standard template and aligned all the rump images before computing the body measurements. Scientific illustrations were created from the aligned images of animals identified as representative of each category to increase clarity and reproducibility. For training material, we created sketches representing the threshold between consecutive categories. Finally, we conducted 2 field reliability studies. In the first test, no training was given to 4 observers, whereas in the second, training using the threshold images was delivered to the same observers. In the first experiment, interobserver results

  20. Consideration of vision and picture quality: psychological effects induced by picture sharpness

    Science.gov (United States)

    Kusaka, Hideo

    1989-08-01

    A psychological hierarchy model of human vision(1)(2) suggests that the visual signals are processed in a serial manner from lower to higher stages: that is "sensation" - "perception" - "emotion." For designing a future television system, it is important to find out what kinds of physical factors affect the "emotion" experienced by an observer in front of the display. This paper describes the psychological effects induced by the sharpness of the picture. The subjective picture quality was evaluated for the same pictures with five different levels of sharpness. The experiment was performed on two kinds of printed pictures: (A) a woman's face, and (B) a town corner. From these experiments, it was found that the amount of high-frequency peaking (physical value of the sharpness) which psychologically gives the best picture quality, differs between pictures (A) and (B). That is, the optimum picture sharpness differs depending on the picture content. From these results, we have concluded that the psychophysical sharpness of the picture is not only determined at the stage of "perception" (e.g., resolution or signal to noise ratio, which everyone can judge immediately), but also at the stage of "emotion" (e.g., sensation of reality or beauty).

  1. Um estudo dos relatos afetivos subjetivos a estímulos do International Affective Picture System em uma amostra geriátrica brasileira Subjective affective ratings to photographic stimuli of the International Affective Picture System in a Brazilian elderly sample

    Directory of Open Access Journals (Sweden)

    Weyler Galvão Porto

    2008-08-01

    Full Text Available INTRODUÇÃO: A literatura científica indica a possibilidade de a percepção da emoção e a formação da memória emocional serem discordantes entre jovens e idosos. A mesma é pobre ao explorar essa possibilidade. Neste estudo, relatamos os resultados obtidos em um experimento-piloto com uma amostra de idosos brasileiros, que classificaram subjetivamente, através da escala Self Assessment Manikin, imagens oriundas do International Affective Picture System. MÉTODO: Quarenta e oito idosos voluntários da Universidade Aberta da Terceira Idade, saudáveis clínica e cognitivamente, avaliaram o caráter alertante e a valência afetiva de 71 imagens do International Affective Picture System, aleatoriamente escolhidas. RESULTADOS: O grau de alerta reportado por idosos diante de um estímulo emocional é tanto maior quanto menor o prazer provocado por essa imagem-estímulo, resultando na existência de uma forte correlação negativa (r = 0,93 entre o grau de alerta e o estímulo desprazeroso. Em uma comparação do acima obtido com outro experimento normativo semelhante feito com jovens brasileiros e americanos, apontou-se para uma possível diferença cultural na forma de relatar subjetivamente um estímulo emocional. CONCLUSÕES: Os resultados obtidos com esta amostra estudada sugerem que pode existir uma diferença nos relatos afetivos entre os jovens e idosos, onde uma normatização do International Affective Picture System para uma amostra maior, representativa da população de idosos, seria útil para responder esta questão.INTRODUCTION: The scientific literature points to a possible bias in the form perception and emotional memory are constructed when elderly and young individuals are compared. However, this possibility is underexplored. This paper presents the results obtained from a pilot study based on an elderly emotional subjective report after evaluation using the International Affective Picture System images and Self Assessment

  2. Looking at the “mental picture of reality” of an efl teacher: a systemic functional analysis Looking at the “mental picture of reality” of an efl teacher: a systemic functional analysis

    Directory of Open Access Journals (Sweden)

    Luciani S. de O Malatér

    2008-04-01

    Full Text Available In this study, I analyze an interview conducted with a Brazilian EFL teacher. Through the analysis of transitivity, I aim at understanding how he2 encodes his teaching xperience and professional roles. The study highlights some of the potentialities of systemic functional linguistics (SFL (Halliday, 1994 as a theoretical framework to be used to categorize teachers’ discourse, making both the discussion and interpretation of data more systematic. Analysis of the research participant’s discourse reveals, on the one hand, his concerns with the quality and development of his teaching practice, as well as with his learners’ needs. The analysis also shows, on the other hand, that he does not seem to share his professional responsibilities collaboratively with his colleagues and students. These findings may be helpful to debates in language teacher education for the benefit of both prospective and practicing teachers. In this study, I analyze an interview conducted with a Brazilian EFL teacher. Through the analysis of transitivity, I aim at understanding how he2 encodes his teaching xperience and professional roles. The study highlights some of the potentialities of systemic functional linguistics (SFL (Halliday, 1994 as a theoretical framework to be used to categorize teachers’ discourse, making both the discussion and interpretation of data more systematic. Analysis of the research participant’s discourse reveals, on the one hand, his concerns with the quality and development of his teaching practice, as well as with his learners’ needs. The analysis also shows, on the other hand, that he does not seem to share his professional responsibilities collaboratively with his colleagues and students. These findings may be helpful to debates in language teacher education for the benefit of both prospective and practicing teachers.

  3. Streamlining the Discovery, Evaluation, and Integration of Data, Models, and Decision Support Systems: a Big Picture View

    Science.gov (United States)

    21st century environmental problems are wicked and require holistic systems thinking and solutions that integrate social and economic knowledge with knowledge of the environment. Computer-based technologies are fundamental to our ability to research and understand the relevant sy...

  4. A reliable, low-cost picture archiving and communications system for small and medium veterinary practices built using open-source technology.

    Science.gov (United States)

    Iotti, Bryan; Valazza, Alberto

    2014-10-01

    Picture Archiving and Communications Systems (PACS) are the most needed system in a modern hospital. As an integral part of the Digital Imaging and Communications in Medicine (DICOM) standard, they are charged with the responsibility for secure storage and accessibility of the diagnostic imaging data. These machines need to offer high performance, stability, and security while proving reliable and ergonomic in the day-to-day and long-term storage and retrieval of the data they safeguard. This paper reports the experience of the authors in developing and installing a compact and low-cost solution based on open-source technologies in the Veterinary Teaching Hospital for the University of Torino, Italy, during the course of the summer of 2012. The PACS server was built on low-cost x86-based hardware and uses an open source operating system derived from Oracle OpenSolaris (Oracle Corporation, Redwood City, CA, USA) to host the DCM4CHEE PACS DICOM server (DCM4CHEE, http://www.dcm4che.org ). This solution features very high data security and an ergonomic interface to provide easy access to a large amount of imaging data. The system has been in active use for almost 2 years now and has proven to be a scalable, cost-effective solution for practices ranging from small to very large, where the use of different hardware combinations allows scaling to the different deployments, while the use of paravirtualization allows increased security and easy migrations and upgrades.

  5. Teaching Grammar Using Pictures

    Directory of Open Access Journals (Sweden)

    Henny Uswatun Hasanah

    2015-05-01

    Full Text Available Teaching is a process of communication. It has to be created through the way ofteaching and exchanging the message or information by every teacher and student. The message can be knowledge, skills, ideas, experiences, and manyothers. Through the process of communication, the people can receive the message or information. To avoid misunderstanding in the process ofcommunication, media are needed in the process of teaching. Using pictures can make exercises and activities more interesting and more interactive. We canconstantly improve our activities by looking at what went well and what fell flat. These 5 unique ways to practice grammar using pictures are a jumping offpoint, and can be expanded in lots of interesting ways. 

  6. My Favorite Picture

    Institute of Scientific and Technical Information of China (English)

    赵阳

    2007-01-01

    <正>I have many pictures.But one of them is my favortie.Now,I introduce it to everyone.The picture has three people.They are mother,father and I.Look! This is me.I am in middle of them.I have long,black hair.I have black eyes and red mouth.I like drawing pictures.My favorite food is noodle,and I don’t like to eat dumplings.Look! On the right is my father,my father is tall and he has black hair and black eyes.He likes to play ping-pong.My mother is on the left.She has black,curly hair.Her mouth is big.We have the same big mouths.She likes to go for a walk in the park.I am very pretty.My father is handsome and my mother is beautiful.I love my family very much.

  7. Getting a Picture.

    Science.gov (United States)

    Nagel, Daniel A; Stacey, Dawn; Momtahan, Kathryn; Gifford, Wendy; Doucet, Shelley; Etowa, Josephine B

    2017-03-01

    Delivery of care by nurses in virtual environments is rapidly increasing with uptake of digitally mediated technologies, such as remote patient monitoring (RPM). Knowing the person is a phenomenon in nursing practice deemed requisite to building relationships and informing clinical decisions, but it has not been studied in virtual environments. The intent of this study was to explicate the processes of how nurses come to know the person using RPM, one form of telehealth technology used in a virtual environment. The study was informed by Charmaz's constructivist grounded theory and included 33 interviews and 5 observational experiences of nurses using RPM in 7 different settings. Getting a Picture evolved as the core category to a theoretical conceptualization of nurses knowing the person through use of RPM and other technologies, such as telephone and electronic medical records. Getting a Picture reflected a dynamic flow and integration of seven processes, such as Connecting With the Person and Recording and Reflecting, to describe how nurses strove to attain a visualization of the person. While navigating disparate and disconnected information and communication technologies, Getting a Picture was important for providing safe, holistic, person-centered care.

  8. Different Loci of Semantic Interference in Picture Naming vs. Word-Picture Matching Tasks.

    Science.gov (United States)

    Harvey, Denise Y; Schnur, Tatiana T

    2016-01-01

    Naming pictures and matching words to pictures belonging to the same semantic category impairs performance relative to when stimuli come from different semantic categories (i.e., semantic interference). Despite similar semantic interference phenomena in both picture naming and word-picture matching tasks, the locus of interference has been attributed to different levels of the language system - lexical in naming and semantic in word-picture matching. Although both tasks involve access to shared semantic representations, the extent to which interference originates and/or has its locus at a shared level remains unclear, as these effects are often investigated in isolation. We manipulated semantic context in cyclical picture naming and word-picture matching tasks, and tested whether factors tapping semantic-level (generalization of interference to novel category items) and lexical-level processes (interactions with lexical frequency) affected the magnitude of interference, while also assessing whether interference occurs at a shared processing level(s) (transfer of interference across tasks). We found that semantic interference in naming was sensitive to both semantic- and lexical-level processes (i.e., larger interference for novel vs. old and low- vs. high-frequency stimuli), consistent with a semantically mediated lexical locus. Interference in word-picture matching exhibited stable interference for old and novel stimuli and did not interact with lexical frequency. Further, interference transferred from word-picture matching to naming. Together, these experiments provide evidence to suggest that semantic interference in both tasks originates at a shared processing stage (presumably at the semantic level), but that it exerts its effect at different loci when naming pictures vs. matching words to pictures.

  9. Role of IAPs in prostate cancer progression: immunohistochemical study in normal and pathological (benign hyperplastic, prostatic intraepithelial neoplasia and cancer human prostate

    Directory of Open Access Journals (Sweden)

    Olmedilla Gabriel

    2010-01-01

    Full Text Available Abstract Background In this study was investigate IAPs in normal human prostate (NP, benign prostatic hyperplasia (BPH, prostatic intraepithelial neoplasia (PIN and prostatic carcinoma (PC, and their involvement in apoptosis/proliferation via NF-kB (TNF-α, IL-1 stimulation. Methods Immunohistochemical and Western blot analyses were performed in 10 samples of normal prostates, 35 samples of BPH, 27 samples diagnosis of PIN (with low-grade PIN or high-grade PIN and 95 samples of PC (with low, medium or high Gleason grades. Results In NP, cytoplasm of epithelial cells were positive to c-IAP1/2 (80% of samples, c-IAP-2 (60%, ILP (20%, XIAP (20%; negative to NAIP and survivin. In BPH, epithelial cells were immunostained to c-IAP1/2 (57.57%, c-IAP-2 (57.57%, ILP (66.6%, NAIP (60.6%, XIAP (27.27%, survivin (9.1%. Whereas low-grade PIN showed intermediate results between NP and BPH; results in high-grade PIN were similar to those found in PC. In PC, epithelial cells were immunostained to c-IAP1/2, c-IAP-2, ILP, NAIP, XIAP (no Gleason variation and survivin (increasing with Gleason. Conclusions IAPs could be involved in prostate disorder (BPH, PIN and PC development since might be provoke inhibition of apoptosis and subsequently cell proliferation. At the same time, different transduction pathway such as IL-1/NIK/NF-kB or TNF/NF-kB (NIK or p38 also promotes proliferation. Inhibitions of IAPs, IL-1α and TNFα might be a possible target for PC treatment since IAPs are the proteins that inhibited apoptosis (favour proliferation and IL-1α and TNFα would affect all the transduction pathway involucrate in the activation of transcription factors related to survival or proliferation (NF-kB, Elk-1 or ATF-2.

  10. 一种基于 IAP15F2K61S2的无线视频智能小车的设计%Design of Wireless Video Intelligent Car based on IAP15F2K61S2

    Institute of Scientific and Technical Information of China (English)

    王林

    2015-01-01

    This paper introduced a design scheme of wireless video intelligent car , which uses IAP15F2K61S2 as the main control chip and uses T6836WTP network camera to complete the real -time acqui-sition of environmental image .The Intelligent car communicates with the remote host by wireless WIFI network:it receives the moving control command from the remote host and transmits the video image data back .Experi-ments show that this system has high flexibility and reliability , which can satisfy the requirements of video sur-veillance under some special circumstances such as the industrial field and mine .%介绍了一种无线视频智能小车的设计方案。该方案以IAP15 F2 K61 S2单片机为控制核心,采用网络摄像头T6836WTP完成实时环境图像的采集。智能小车通过无线WIFI网络与远程上位机进行通信,接收行进控制命令并将视频图像数据回传。测试表明,该系统具有较高的灵活性和可靠性,能满足工业、矿井等特殊环境下的视频监控需求。

  11. Perceived control in clinically anxious and non-anxious children indirectly measured with the Implicit Association Procedure (IAP)

    NARCIS (Netherlands)

    Hogendoorn, S.M.; Vervoort, L.; Wolters, L.H.; Prins, P.J.M.; de Haan, E.; Hartman, C.A.; Nauta, M.H.; Boer, F.

    2012-01-01

    Background: Perceived control is thought to play an important role in the development and maintenance of anxiety disorders in children. The objective of the present study was to further investigate the Perceived Control Implicit Association Procedure (IAP, Hogendoorn et al., 2008) as an indirect mea

  12. Interference in Joint Picture Naming

    Science.gov (United States)

    Gambi, Chiara; Van de Cavey, Joris; Pickering, Martin J.

    2015-01-01

    In 4 experiments we showed that picture naming latencies are affected by beliefs about the task concurrently performed by another speaker. Participants took longer to name pictures when they believed that their partner concurrently named pictures than when they believed their partner was silent (Experiments 1 and 4) or concurrently categorized the…

  13. The polycentric picture

    DEFF Research Database (Denmark)

    Flensborg, Ingelise

    2008-01-01

    The polycentric picture The presentation introduces a dynamic view on children's drawings inspired by J.J.Gibson's ecological approach to visual perception. Empirical research in children's drawings will be the basis for the documentation of the fact that children's drawings contain several...... strategies of vision, which can be activated, re-established and differentiated in relation to dynamic media productions. The significance of spatial orientation to our ability to see and to the way we are seeing is focused and a concept of the ex-centric observer is introduced....

  14. Simulation of 14C in IAP/LASG L30T63 Ocean Model

    Institute of Scientific and Technical Information of China (English)

    LI Qingquan; SHI Guangyu

    2005-01-01

    14C plays an important role in the study of ocean circulation and anthropogenic CO2. Radioactive 14C is usually used in ocean carbon circulation model to test the physical performance of model. In the present paper, a 14C model is established and coupled with the IAP/LASG L30T63 global ocean circulation model to simulate the distribution of natural 14C in oceans and the penetration and uptake of 14C in oceans after industrial revolution and nuclear bomb test. The simulation of natural 14C reveals the basic characteristics of oceanic ventilation. However, simulation value is "younger" than observation in the Pacific and Indian Oceans, and "older" than observation in the Atlantic deep ocean. The simulation of bomb 14C agrees well with GEOSECS observation, but the volume inventory and averaged penetration depth of bomb 14C in oceans are smaller than observation. The probable reasons for these discrepancies are analyzed.

  15. Friendship IAP, Maryland. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

    Science.gov (United States)

    1982-05-04

    USAFETAC PSYCHROMETRIC SUMMARY’k A1 dEATHER SERVXCE/MAC STATIO STATION 041A vt LS MONT. PAGE I1 - i(Fl WI~III~i~i1IIi ET SUL& TESIPEXATUnE DEPRESION (F...WEATHER SERVICE/MAC L2AD0. FRIENDOSHIP IAP MD 74-S1orf STATION STATION *464 VtAAS M. PAGE 2 -nn-nn Th.~.WIT SUL$ TEMPERATURE DEPRESION (F) ITOTAL TOTAL () 0...Alte WEAT.4ER SERVICE/IAC 776ff F7hnSHTP Ti A mn-t ER STAION NWA YA PAGE 1 WE? BULB TEMPERATURE DEPRESION (F) TOTAL 1 TOTAL (I 0 1.2 j3-43. 7. 9. . 1o 1

  16. Designing a Regional Nitrogen Cycle Module of Grassland for the IAP-N Model

    Institute of Scientific and Technical Information of China (English)

    YUE Jin; HAN Shenghui; ZHENG Xunhua

    2012-01-01

    Assessment of the nitrogen (N) balance and its long-term trend is necessary for management practices because of the negative environmental effects caused by an imbalance of reactive N in grassland ecosystems.In this study,we designed a module for the IAP-N (Improving Anthropogenic Practices of managing reactive Nitrogen) model to enable it to assess the N budget of regional grasslands.The module was developed to quantify the individual components of the N inputs and outputs for grassland ecosystems using livestock and human populations,grassland area,and fossil-energy consumption data as the model inputs.In this paper,the estimation approaches for individual components of N budget,data acquisition,and parameter selection are described in detail.The model was applied to assess the N budget of Inner Mongolia in 2006 at the county scale.The simulation results show that the most important pathway of N outputs from the grassland was livestock intake.The N output from livestock intake was especially large in the middle of Inner Mongolia.Biological fixation,atmospheric deposition,and livestock excreta deposition were comparably important for the N inputs into the grassland.The N budget for Inner Mongolia grassland in 2006 was -1.7× 108±0.6× 108 kg.The case study for Inner Mongolia shows that the new grassland module for the IAP-N model can capture the characteristics of the N budget in a semiarid grassland.

  17. The Academy Color Encoding System (ACES: A Professional Color-Management Framework for Production, Post-Production and Archival of Still and Motion Pictures

    Directory of Open Access Journals (Sweden)

    Walter Arrighetti

    2017-09-01

    Full Text Available The Academy of Motion Picture Arts and Sciences has been pivotal in the inception, design and later adoption of a vendor-agnostic and open framework for color management, the Academy Color Encoding System (ACES, targeting theatrical, TV and animation features, but also still-photography and image preservation at large. For this reason, the Academy gathered an interdisciplinary group of scientists, technologists, and creatives, to contribute to it so that it is scientifically sound and technically advantageous in solving practical and interoperability problems in the current film production, postproduction and visual-effects (VFX ecosystem—all while preserving and future-proofing the cinematographers’ and artists’ creative intent as its main objective. In this paper, a review of ACES’ technical specifications is provided, as well as the current status of the project and a recent use case is given, namely that of the first Italian production embracing an end-to-end ACES pipeline. In addition, new ACES components will be introduced and a discussion started about possible uses for long-time preservation of color imaging in video-content heritage.

  18. Seasonal Prediction of the Global Precipitation Annual Modes with the Grid-Point Atmospheric Model of IAP LASG

    Institute of Scientific and Technical Information of China (English)

    WU Zhiwei; LI Jianping

    2009-01-01

    A right annual cycle is of critical importance for a model to improve its seasonal prediction skill. This work assesses the performance of the Grid-point Atmospheric Model of IAP LASG (GAMIL) in retrospective prediction of the global precipitation annual modes for the 1980-2004 period. The annual modes are gauged by a three-parameter metrics: the long-term annual mean and two major modes of annual cycle (AC), namely, a solstitial mode and an equinoctial asymmetric mode. The results demonstrate that the GAMIL one-month lead prediction is basically able to capture the major patterns of the long-term annual mean as well as the first AC mode (the solstitial monsoon mode). The GAMIL has deficiencies in reproducing the second AC mode (the equinoctial asymmetric mode). The magnitude of the GAMIL prediction tends to be greater than the observed precipitation, especially in the sea areas including the Arabian Sea, the Bay of Bengal (BOB), and the western North Pacific (WNP). These biases may be due to underestimation of the convective activity predicted in the tropics, especially over the western Pacific warm pool (WPWP) and its neighboring areas. It is suggested that a more accurate parameterization of convection in the tropics, especially in the Maritime Continent, the WPWP and its neighboring areas, may be critical for reproducing the more realistic annual modes, since the enhancement of convective activity over the WPWP and its vicinity can induce suppressed convection over the WNP, the BOB, and the South Indian Ocean where the GAMIL produces falsely vigorous convections. More efforts are needed to improve the simulation not only in monsoon seasons but also in transitional seasons when the second AC mode takes place. Selection of the one-tier or coupled atmosphere-ocean system may also reduce GAMIL seasonal prediction skill.

  19. Non-canonical NF-κB activation and abnormal B cell accumulation in mice expressing ubiquitin protein ligase-inactive c-IAP2.

    Directory of Open Access Journals (Sweden)

    Dietrich B Conze

    Full Text Available Chromosomal translocations between loci encoding MALT1 and c-IAP2 are common in MALT lymphomas. The resulting fusion proteins lack the c-IAP2 RING domain, the region responsible for its ubiquitin protein ligase (E3 activity. Ectopic expression of the fusion protein activates the canonical NF-κB signaling cascade, but how it does so is controversial and how it promotes MALT lymphoma is unknown. Considering recent reports implicating c-IAP1 and c-IAP2 E3 activity in repression of non-canonical NF-κB signaling, we asked if the c-IAP2/MALT fusion protein can initiate non-canonical NF-κB activation. Here we show that in addition to canonical activation, the fusion protein stabilizes NIK and activates non-canonical NF-κB. Canonical but not non-canonical activation depended on MALT1 paracaspase activity, and expression of E3-inactive c-IAP2 activated non-canonical NF-κB. Mice in which endogenous c-IAP2 was replaced with an E3-inactive mutant accumulated abnormal B cells with elevated non-canonical NF-κB and had increased numbers of B cells with a marginal zone phenotype, gut-associated lymphoid hyperplasia, and other features of MALT lymphoma. Thus, the c-IAP2/MALT1 fusion protein activates NF-κB by two distinct mechanisms, and loss of c-IAP2 E3 activity in vivo is sufficient to induce abnormalities common to MALT lymphoma.

  20. Pictures of the month

    CERN Multimedia

    Claudia Marcelloni de Oliveira

    Starting with this issue, we will publish special pictures illustrating the ongoing construction and commissioning efforts. If you wish to have a professionnal photographer immortalize your detector before it disappears in the heart of ATLAS or for a special event, don't hesitate to contact Claudia Marcelloni de Oliveira (16-3687) from the CERN photo service. Members of the pixel team preparing to insert the outermost layer (the outer of the three barrel pixel layers) into the Global Support Frame for the Pixel Detector in SR1. Ongoing work on the first Big Wheel on the C side. Exploded view of the side-C Big Wheel and the barrel cryostat. The TRT Barrel services (HV, LV, cooling liquid, active gas, flushing gas) are now completely connected and tested. Hats off to Kirill Egorov, Mike Reilly, Ben Legeyt and Godwin Mayers who managed to fit everything within the small clearance margin!

  1. Nation's water picture mixed

    Science.gov (United States)

    The nation's water picture for April showed mixed trends: More than half of the index gaging stations reported normal streamflow conditions during the month, while the spring snowmelt boosted streamflow in the Northeast and Northwest to well above normal levels. Parts of the Southeast, however, from West Virginia south to the Carolinas, reported well-below normal streamflow conditions, according to a month-end check on water resources conditions by the U.S. Geological Survey, Department of the Interior.After nearly 2 years of drought conditions the three major reservoirs supplying New York City reached full storage capacity and were spilling during April. Combined contents of the three reservoirs on May 1, 1982, was 272 billion gallons, 101% of their full usable capacity. The full reservoirs and the generally good surface and groundwater conditions throughout the Delaware River basin allowed the Delaware River Basin Commission to lift its drought emergency warning on April 27.

  2. Landscape as World Picture

    DEFF Research Database (Denmark)

    Wamberg, Jacob

    Age, among the powers-that-be. The topic of Volume II is the breakthrough of the modern landscape image and its new perspectival vistas, transient time and cultivated - or completely deserted - terrains. This post-medieval paradigm shift is construed as the mature stage in the evolution of self......-consciousness, with an urban individual contemplating nature at an aesthetic distance. Apart from being structurally equivalent with the new Copernican cosmos and the colonial expansion of Western culture, the new territorial landscape image is shown to develop in close interaction with the early modern work ethic...... from Palaeolithic cave paintings through to 19th-century modernity. A structuralist comparison between this pattern and three additional fields of analysis - self-consciousness, socially-determined perception of nature, and world picture - reveals a fascinating insight into culture's macrohistorical...

  3. Landscape as World Picture

    DEFF Research Database (Denmark)

    Wamberg, Jacob

    -consciousness, with an urban individual contemplating nature at an aesthetic distance. Apart from being structurally equivalent with the new Copernican cosmos and the colonial expansion of Western culture, the new territorial landscape image is shown to develop in close interaction with the early modern work ethic......This book presents a new and comprehensive theory concerning the manner in which landscapes in Western pictorial art may be interpreted in relation to the cultures that created them. Its point of departure is a hitherto unexplored developmental pattern that characterises landscape representation...... from Palaeolithic cave paintings through to 19th-century modernity. A structuralist comparison between this pattern and three additional fields of analysis - self-consciousness, socially-determined perception of nature, and world picture - reveals a fascinating insight into culture's macrohistorical...

  4. Comparative Analysis of Radiographic Hip Joint Geometry Using Measurement Tools on Picture Archiving and Communication System: A Prospective Study of 100 Pelvic Radiographs of Koreans.

    Science.gov (United States)

    Kim, Seung-Chan; Lim, Young-Wook; Kwon, Soon-Yong; Lee, Jun-Ku; Park, Il-Kyu; Kim, Yong-Sik

    2016-11-01

    A contralateral normal hip joint has been often used as a reference standard in preoperative planning and intraoperative assessment of hip arthroplasty, with the assumption that bilateral hip joint geometries have no significant differences. However, one previous study using analog measurements on hardcopy films reported significant bilateral variation in hip joint geometry. We therefore investigated the level of agreement between the right and left hips for each measurement and determined index values and the range of normal bilateral variations. We assessed 100 standard anteroposterior radiographs of the pelvis in this study. Two independent observers measured the actual value of femoral head diameter, location of the femoral head center, acetabular offset, femoral offset, hip offset, greater trochanteric height, neck-shaft angle, medullary canal diameter, and proximal femoral diameter. Intraclass correlation coefficients (ICCs) and values of mean difference were calculated for each measurement. The results demonstrated perfect agreement (ICC >0.8) between the right and left hips for most parameters and substantial agreement for greater trochanteric height (ICC = 0.735) and femoral offset (ICC = 0.773). The mean difference and standard deviation in the measurement between the right and left hips for the location of the femoral head center and the acetabular offset were 0.60 ± 0.48 mm and 0.42 ± 0.30 mm, respectively. Hip joint geometry is not influenced by side. In hip arthroplasty, a contralateral normal hip can be reliably used as a guide for preoperative planning using measurement tools on a picture archiving and communication system. Copyright © 2016 Elsevier Inc. All rights reserved.

  5. IAP RAS microwave radiometry complex: sounding atmospheric thermal structure from the ground up to 55km.

    Science.gov (United States)

    Belikovich, Mikhail; Shvetsov, Alexander; Ryskin, Vitaly; Mukhin, Dmitry; Kulikov, Mikhail; Feigin, Alexander

    2016-04-01

    Thermal structure is the key characteristic of the atmosphere. Depending on the altitude, it is measured by different methods. In troposphere a plethora of in-situ techniques exists while in middle atmosphere remote sensing is primary type of measurement. The remote sensing is conducted in different wavelengths: optical, infrared and microwave. Satellite based measurements are the most popular kind of remote sensing measurements as it provides global coverage. Ground based passive microwave remote sensing technique has its place when one need permanent monitoring with high time resolution in order to study short-term local events like gravity waves. Institute of Applied Physics of the Russian Academy of Sciences (IAP RAS) develops multi-purpose radiometry complex for constant atmospheric monitoring. For now, it measures temperature profiles from ground to 55km, tropospheric water vapor and ozone. It consists of several radiometers with spectral bands ranging from 20 to 112 GHz. In 2015 two radiometers were added in order to measure thermal structure at surface level and troposphere: scanning device operating in 55-59GHz, and device at 50-55GHz. The change led to modifying the retrieval software. The work presents the description of the radiometry complex and corresponding retrieval software. The main part is devoted to new radiometers and enhancements in retrieval procedure. The retrieval algorithms are described: for each device separately and for the whole temperature retrieval part of the complex. The use of the single procedure for the group of radiometers helps to merge the profile with each other correctly. The main issue of the single procedure (numerical complexity aside) is dealing with the possible difference in calibration of the devices. Error analysis of the procedures is conducted. The characteristics of the complex and the retrieval algorithms are presented. The capabilities of the algorithms are shown on simulated and real data; the last one was

  6. Painting Pictures with Whisky

    Science.gov (United States)

    Kim, Hyoungsoo; Boulogne, François; Um, Eujin; Jacobi, Ian; Stone, Howard

    2014-11-01

    Have you ever looked at the dried mark of whisky on the glass? While the whisky evaporates, various solid components inside the whisky are deposited with a peculiar pattern, which creates a beautiful picture. This particle patterning is induced by the solutal Marangoni effect. We investigate this effect on both the flow behavior and the particle deposition patterns in binary-mixture droplet evaporation by varying the concentration ratio between ethanol and water. To visualize the particle and fluid motion, we perform Particle Image Velocimetry. We observe that at the beginning stage complex circulating flow patterns occurred, which are triggered by the surface tension gradient, i.e. Marangoni effect. Ethanol first evaporates due to the lower vapor pressure compared to water. When the ethanol has vanished, a radial flow pattern is observed. Furthermore, we find that as the initial ethanol concentration increases, the mobility of the receding contact line increased. At high ethanol concentrations, the contact line kept receding so as to draw groups of particles that deposited in an annular pattern. We thank Ernie Button for sharing with us many beautiful images of whisky after it had dried.

  7. Assessment of lichen diversity by index of atmospheric purity (IAP), index of human impact (IHI) and other environmental factors in an urban area (Grenoble, southeast France).

    Science.gov (United States)

    Gombert, S; Asta, J; Seaward, M R D

    2004-05-25

    An assessment of air quality in the Grenoble area was made using the index of atmospheric purity (IAP). The survey area was divided into 198 units (0.7 x 1 km), in which 345 average lichen relevés were analyzed according to the Braun-Blanquet method. Each relevé station was characterized in the field by a subjective index of human impact (IHI) calculated according to four local environmental parameters influencing the epiphytic lichen flora: urbanization (urban, suburban or rural area), road traffic (low or high), local developments (stations located within crop fields, green areas, housing sites or car parks), and exposure (trees isolated, in rows or grouped). Eighty-three epiphytic lichen species and two algae were recorded and grouped into three ecological categories defined according to bark type and nutrient needs: nitrophytic, neutrophytic and acidophytic species. IAP values, varying from 5.9 to 71.7, were clustered into five categories in order to produce an air-quality map. The geographical pattern of the IAP map showed no clear connection with local sources of pollution, such as the vicinity of a road or an industrial plant, and was not correlated with annual mean values of SO(2), NO(2) and NO for the years 1994-1997. IAP appeared to be influenced by environmental artificiality as shown by a polynomial trend observed between IAP and IHI, even if IAP values were broadly scattered. Multivariate analysis (canonical correspondence) showed that high IAP values could be observed in stations of "natural" environments at high elevations and in stations of "artificial" environments at low elevations. It was also shown that IAP varied in relation to the relative proportion of ecological groups of lichen relevés: although a majority of neutrophytic species (>50%) with a much lower percentage of nitrophytic species generally characterized high IAP, a predominance of acidophytic or nitrophytic species led to a decrease in the IAP. A correlation between nitrophytic

  8. North America - The Energy Picture II

    Science.gov (United States)

    2006-01-01

    Servicio Público de Energía Eléctrica or LSPEE) was amended to allow private participation in generation activities. Article 3 of this Act lists...Desarrollo Urbano ), of the National Urban System (Sistema Urbano Nacional), and of the specific urban North America – The Energy Picture II

  9. IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis.

    Science.gov (United States)

    Gyrd-Hansen, Mads; Darding, Maurice; Miasari, Maria; Santoro, Massimo M; Zender, Lars; Xue, Wen; Tenev, Tencho; da Fonseca, Paula C A; Zvelebil, Marketa; Bujnicki, Janusz M; Lowe, Scott; Silke, John; Meier, Pascal

    2008-11-01

    The covalent attachment of ubiquitin to target proteins influences various cellular processes, including DNA repair, NF-kappaB signalling and cell survival. The most common mode of regulation by ubiquitin-conjugation involves specialized ubiquitin-binding proteins that bind to ubiquitylated proteins and link them to downstream biochemical processes. Unravelling how the ubiquitin-message is recognized is essential because aberrant ubiquitin-mediated signalling contributes to tumour formation. Recent evidence indicates that inhibitor of apoptosis (IAP) proteins are frequently overexpressed in cancer and their expression level is implicated in contributing to tumorigenesis, chemoresistance, disease progression and poor patient-survival. Here, we have identified an evolutionarily conserved ubiquitin-associated (UBA) domain in IAPs, which enables them to bind to Lys 63-linked polyubiquitin. We found that the UBA domain is essential for the oncogenic potential of cIAP1, to maintain endothelial cell survival and to protect cells from TNF-alpha-induced apoptosis. Moreover, the UBA domain is required for XIAP and cIAP2-MALT1 to activate NF-kappaB. Our data suggest that the UBA domain of cIAP2-MALT1 stimulates NF-kappaB signalling by binding to polyubiquitylated NEMO. Significantly, 98% of all cIAP2-MALT1 fusion proteins retain the UBA domain, suggesting that ubiquitin-binding contributes to the oncogenic potential of cIAP2-MALT1 in MALT lymphoma. Our data identify IAPs as ubiquitin-binding proteins that contribute to ubiquitin-mediated cell survival, NF-kappaB signalling and oncogenesis.

  10. The IAP-antagonist ARTS initiates caspase activation upstream of cytochrome C and SMAC/Diablo

    Science.gov (United States)

    Edison, N; Zuri, D; Maniv, I; Bornstein, B; Lev, T; Gottfried, Y; Kemeny, S; Garcia-Fernandez, M; Kagan, J; Larisch, S

    2012-01-01

    ARTS (Sept4_i2) is a pro-apoptotic tumor suppressor protein that functions as an antagonist of X-linked IAP (XIAP) to promote apoptosis. It is generally thought that mitochondrial outer membrane permeabilization (MOMP) occurs before activation of caspases and is required for it. Here, we show that ARTS initiates caspase activation upstream of MOMP. In living cells, ARTS is localized to the mitochondrial outer membrane. In response to apoptotic signals, ARTS translocates rapidly to the cytosol in a caspase-independent manner, where it binds XIAP and promotes caspase activation. This translocation precedes the release of cytochrome C and SMAC/Diablo, and ARTS function is required for the normal timing of MOMP. We also show that ARTS-induced caspase activation leads to cleavage of the pro-apoptotic Bcl-2 family protein Bid, known to promote MOMP. We propose that translocation of ARTS initiates a first wave of caspase activation that can promote MOMP. This leads to the subsequent release of additional mitochondrial factors, including cytochrome C and SMAC/Diablo, which then amplifies the caspase cascade and causes apoptosis. PMID:21869827

  11. EXPERIMENTS OF A REDUCED GRID IN LASG/IAP WORLD OCEAN GENERAL CIRCULATION MODELS (OGCMs)

    Institute of Scientific and Technical Information of China (English)

    LIU Xiying; LIU Hailong; ZHANG Xuehong; YU Rucong

    2006-01-01

    Due to the decrease in grid size associated with the convergence of meridians toward the poles in spherical coordinates, the time steps in many global climate models with finite-difference method are restricted to be unpleasantly small. To overcome the problem, a reduced grid is introduced to LASG/IAP world ocean general circulation models. The reduced grid is implemented successfully in the coarser resolutions version model L30T63 at first. Then, it is carried out in the improved version model LICOM with finer resolutions. In the experiment with model L30T63, under time step unchanged though, execution time per single model run is shortened significantly owing to the decrease of grid number and filtering execution in high latitudes. Results from additional experiments with L30T63 show that the time step of integration can be quadrupled at most in reduced grid with refinement ratio 3. In the experiment with model LICOM and with the model's original time step unchanged, the model covered area is extended to the whole globe from its original case with the grid point of North Pole considered as an isolated island and the results of experiment are shown to be acceptable.

  12. Development of Impregnated Agglomerate Pelletization (IAP) process for fabrication of (Th,U)O 2 mixed oxide pellets

    Science.gov (United States)

    Khot, P. M.; Nehete, Y. G.; Fulzele, A. K.; Baghra, Chetan; Mishra, A. K.; Afzal, Mohd.; Panakkal, J. P.; Kamath, H. S.

    2012-01-01

    Impregnated Agglomerate Pelletization (IAP) technique has been developed at Advanced Fuel Fabrication Facility (AFFF), BARC, Tarapur, for manufacturing (Th, 233U)O 2 mixed oxide fuel pellets, which are remotely fabricated in hot cell or shielded glove box facilities to reduce man-rem problem associated with 232U daughter radionuclides. This technique is being investigated to fabricate the fuel for Indian Advanced Heavy Water Reactor (AHWR). In the IAP process, ThO 2 is converted to free flowing spheroids by powder extrusion route in an unshielded facility which are then coated with uranyl nitrate solution in a shielded facility. The dried coated agglomerate is finally compacted and then sintered in oxidizing/reducing atmosphere to obtain high density (Th,U)O 2 pellets. In this study, fabrication of (Th,U)O 2 mixed oxide pellets containing 3-5 wt.% UO 2 was carried out by IAP process. The pellets obtained were characterized using optical microscopy, XRD and alpha autoradiography. The results obtained were compared with the results for the pellets fabricated by other routes such as Coated Agglomerate Pelletization (CAP) and Powder Oxide Pelletization (POP) route.

  13. USING PICTURES IN ENGLISH CLASSES

    Institute of Scientific and Technical Information of China (English)

    1994-01-01

    Introduction In China, some English teachers go to class with only a textbook and a teaching plan, nothing else. After a while, the students complain that their classes are becoming more and more boring. Teachers have tried many ways to make their classes more interesting, motivating and effective, but using pictures in the classroom to do this has not been a popular method. The world provides us with all kinds of beautiful pictures. There is no reason why we should not make better use of them in language learning and teaching. This article will discuss the reasons for using pictures, suggest ways of collecting pictures and ways of using pictures in reading, writing, listening and speaking classes.

  14. Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production.

    Science.gov (United States)

    Kearney, Conor J; Sheridan, Clare; Cullen, Sean P; Tynan, Graham A; Logue, Susan E; Afonina, Inna S; Vucic, Domagoj; Lavelle, Ed C; Martin, Seamus J

    2013-02-15

    Inhibitor of apoptosis proteins (IAPs) play a major role in determining whether cells undergo apoptosis in response to TNF as well as other stimuli. However, TNF is also highly proinflammatory through its ability to trigger the secretion of multiple inflammatory cytokines and chemokines, which is arguably the most important role of TNF in vivo. Indeed, deregulated production of TNF-induced cytokines is a major driver of inflammation in several autoimmune conditions such as rheumatoid arthritis. Here, we show that IAPs are required for the production of multiple TNF-induced proinflammatory mediators. Ablation or antagonism of IAPs potently suppressed TNF- or RIPK1-induced proinflammatory cytokine and chemokine production. Surprisingly, IAP antagonism also led to spontaneous production of chemokines, particularly RANTES, in vitro and in vivo. Thus, IAPs play a major role in influencing the production of multiple inflammatory mediators, arguing that these proteins are important regulators of inflammation in addition to apoptosis. Furthermore, small molecule IAP antagonists can modulate spontaneous as well as TNF-induced inflammatory responses, which may have implications for use of these agents in therapeutic settings.

  15. Prediction of subjective ratings of emotional pictures by EEG features

    Science.gov (United States)

    McFarland, Dennis J.; Parvaz, Muhammad A.; Sarnacki, William A.; Goldstein, Rita Z.; Wolpaw, Jonathan R.

    2017-02-01

    Objective. Emotion dysregulation is an important aspect of many psychiatric disorders. Brain-computer interface (BCI) technology could be a powerful new approach to facilitating therapeutic self-regulation of emotions. One possible BCI method would be to provide stimulus-specific feedback based on subject-specific electroencephalographic (EEG) responses to emotion-eliciting stimuli. Approach. To assess the feasibility of this approach, we studied the relationships between emotional valence/arousal and three EEG features: amplitude of alpha activity over frontal cortex; amplitude of theta activity over frontal midline cortex; and the late positive potential over central and posterior mid-line areas. For each feature, we evaluated its ability to predict emotional valence/arousal on both an individual and a group basis. Twenty healthy participants (9 men, 11 women; ages 22-68) rated each of 192 pictures from the IAPS collection in terms of valence and arousal twice (96 pictures on each of 4 d over 2 weeks). EEG was collected simultaneously and used to develop models based on canonical correlation to predict subject-specific single-trial ratings. Separate models were evaluated for the three EEG features: frontal alpha activity; frontal midline theta; and the late positive potential. In each case, these features were used to simultaneously predict both the normed ratings and the subject-specific ratings. Main results. Models using each of the three EEG features with data from individual subjects were generally successful at predicting subjective ratings on training data, but generalization to test data was less successful. Sparse models performed better than models without regularization. Significance. The results suggest that the frontal midline theta is a better candidate than frontal alpha activity or the late positive potential for use in a BCI-based paradigm designed to modify emotional reactions.

  16. Effects of picture size reduction and blurring on emotional engagement.

    Directory of Open Access Journals (Sweden)

    Andrea De Cesarei

    Full Text Available The activity of basic motivational systems is reflected in emotional responses to arousing stimuli, such as natural pictures. The manipulation of picture properties such as size or detail allows for investigation into the extent to which separate emotional reactions are similarly modulated by perceptual changes, or, rather, may subserve different functions. Pursuing this line of research, the present study examined the effects of two types of perceptual degradation, namely picture size reduction and blurring, on emotional responses. Both manipulations reduced picture relevance and dampened affective modulation of skin conductance, possibly because of a reduced action preparation in response to degraded or remote pictures. However, the affective modulation of the startle reflex did not vary with picture degradation, suggesting that the identification of these degraded affective cues activated the neural circuits mediating appetitive or defensive motivation.

  17. Simple and efficient method for region of interest value extraction from picture archiving and communication system viewer with optical character recognition software and macro program.

    Science.gov (United States)

    Lee, Young Han; Park, Eun Hae; Suh, Jin-Suck

    2015-01-01

    The objectives are: 1) to introduce a simple and efficient method for extracting region of interest (ROI) values from a Picture Archiving and Communication System (PACS) viewer using optical character recognition (OCR) software and a macro program, and 2) to evaluate the accuracy of this method with a PACS workstation. This module was designed to extract the ROI values on the images of the PACS, and created as a development tool by using open-source OCR software and an open-source macro program. The principal processes are as follows: (1) capture a region of the ROI values as a graphic file for OCR, (2) recognize the text from the captured image by OCR software, (3) perform error-correction, (4) extract the values including area, average, standard deviation, max, and min values from the text, (5) reformat the values into temporary strings with tabs, and (6) paste the temporary strings into the spreadsheet. This principal process was repeated for the number of ROIs. The accuracy of this module was evaluated on 1040 recognitions from 280 randomly selected ROIs of the magnetic resonance images. The input times of ROIs were compared between conventional manual method and this extraction module-assisted input method. The module for extracting ROI values operated successfully using the OCR and macro programs. The values of the area, average, standard deviation, maximum, and minimum could be recognized and error-corrected with AutoHotkey-coded module. The average input times using the conventional method and the proposed module-assisted method were 34.97 seconds and 7.87 seconds, respectively. A simple and efficient method for ROI value extraction was developed with open-source OCR and a macro program. Accurate inputs of various numbers from ROIs can be extracted with this module. The proposed module could be applied to the next generation of PACS or existing PACS that have not yet been upgraded. Copyright © 2015 AUR. Published by Elsevier Inc. All rights reserved.

  18. Pictures in Pictures: Art History and Art Museums in Children's Picture Books

    Science.gov (United States)

    Yohlin, Elizabeth

    2012-01-01

    Children's picture books that recreate, parody, or fictionalize famous artworks and introduce the art museum experience, a genre to which I will refer as "children's art books," have become increasingly popular over the past decade. This essay explores the pedagogical implications of this trend through the family program "Picture Books and Picture…

  19. Wireless system for monitoring Intra-abdominal pressure in patient with severe abdominal pathology

    Science.gov (United States)

    Sokolovskiy, S. S.; Shtotskiy, Y. V.; Leljanov, A. D.

    2017-01-01

    The paper discusses an experimental design of the wireless system for monitoring intra-abdominal pressure (IAP) using Bluetooth Low Energy technology. The possibility of measuring IAP via the bladder using a wireless pressure sensor with a hydrophobic bacteria filter between the liquid transmitting medium and the sensor element is grounded.

  20. Ubiquitous picture-rich content representation

    Science.gov (United States)

    Wang, Wiley; Dean, Jennifer; Muzzolini, Russ

    2010-02-01

    The amount of digital images taken by the average consumer is consistently increasing. People enjoy the convenience of storing and sharing their pictures through online (digital) and offline (traditional) media. A set of pictures can be uploaded to: online photo services, web blogs and social network websites. Alternatively, these images can be used to generate: prints, cards, photo books or other photo products. Through uploading and sharing, images are easily transferred from one format to another. And often, a different set of associated content (text, tags) is created across formats. For example, on his web blog, a user may journal his experiences of his recent travel; on his social network website, his friends tag and comment on the pictures; in his online photo album, some pictures are titled and keyword-tagged. When the user wants to tell a complete story, perhaps in a photo book, he must collect, across all formats: the pictures, writings and comments, etc. and organize them in a book format. The user has to arrange the content of his trip in each format. The arrangement, the associations between the images, tags, keywords and text, cannot be shared with other formats. In this paper, we propose a system that allows the content to be easily created and shared across various digital media formats. We define a uniformed data association structure to connect: images, documents, comments, tags, keywords and other data. This content structure allows the user to switch representation formats without reediting. The framework under each format can emphasize (display or hide) content elements based on preference. For example, a slide show view will emphasize the display of pictures with limited text; a blog view will display highlighted images and journal text; and the photo book will try to fit in all images and text content. In this paper, we will discuss the strategy to associate pictures with text content, so that it can naturally tell a story. We will also list

  1. Simulations of the East Asian Subtropical Westerly Jet by LASG/IAP AGCMs

    Institute of Scientific and Technical Information of China (English)

    GUO Lanli; ZHANG Yaocun; WANG Bin; LI Lijuan; ZHOU Tianjun; BAO Qing

    2008-01-01

    Performances of two LASG/IAP (State Key Laboratory of Numerical Modeling for Atmospheric Sci-ences and Geophysical Fluid Dynamics/Institute of Atmospheric Physics) Atmospheric General Circulation Models (AGCMs), namely GAMIL and SAMIL, in simulating the major characteristics of the East Asian subtropical westerly jet (EASWJ) in the upper troposphere are examined in this paper. The mean vertical and horizontal structures and the correspondence of the EASWJ location to the meridional temperature gradient in the upper troposphere are well simulated by two models. However, both models underestimate the EASWJ intensity in winter and summer, and are unable to simulate the bimodal distribution of the ma-jor EASWJ centers in mid-summer, relative to the observation, especially for the SAMIL model. The biases in the simulated EASWJ intensity are found to be associated with the biases of the meridional temperature gradients in the troposphere, and furthermore with the surface sensible heat flux and condensation latent heating. The models capture the major characteristics of the seasonal evolution of the diabatic heating rate averaged between 30 -45 N, and its association with the westerly jet. However, the simulated maximum diabatic heating rate in summer is located westward in comparison with the observed position, with a rela-tively strong diabatic heating intensity, especially in GAMIL. The biases in simulating the diabatic heating fields lead to the biases in simulating the temperature distribution in the upper troposphere, which may further affect the EASWJ simulations. Therefore, it is necessary to improve the simulation of the meridional temperature gradient as well as the diabatic heating field in the troposphere for the improvement of the EASWJ simulation by GAMIL and SAMIL models.

  2. Questions, pictures, answers: introducing pictures in question-answering systems

    NARCIS (Netherlands)

    Theune, Mariet; van Schooten, B.W.; op den Akker, Hendrikus J.A.; Bosma, W.E.; Hofs, D.H.W.; Nijholt, Antinus; Krahmer, E.J.; van Hooijdonk, C.M.J.; Marsi, E.C.; Ruiz Miyarez, L.; Munoz Alvarado, A.; Alvarez Moreno, C.

    2007-01-01

    We present the Dutch IMIX research programme on multimodal interaction, speech and language technology. We discuss our contributions to this programme in the form of two research projects, IMOGEN and VIDIAM, and the technical integration of the various modules developed by IMIX subprojects to build

  3. Behavioral modulation by mutilation pictures in women

    Directory of Open Access Journals (Sweden)

    Pereira M.G.

    2004-01-01

    Full Text Available Previous studies have shown that women are more emotionally expressive than men. It is unclear, however, if women are also more susceptible to the emotional modulation of behavior imposed by an affective stimulus. To investigate this issue, we devised a task in which female subjects performed six sequential trials of visual target detection following the presentation of emotional (mutilation and erotic or neutral pictures (domestic utensils and objects and compared the data obtained in the present study with those described in a previous study with male subjects. The experiment consisted of three blocks of 24 pictures and each block had an approximate duration of 4 min. Our sample consisted of 36 subjects (age range: 18 to 26 years and each subject performed all blocks. Trials following the presentation of mutilation pictures (283 ms had significantly slower reaction times than those following neutral (270 ms pictures. None of the trials in the "pleasant block" (271 ms was significantly different from those in the "neutral block". The increase in reaction time observed in the unpleasant block may be related in part to the activation of motivational systems leading to an avoidance behavior. The interference effect observed in this study was similar to the pattern previously described for men. Thus, although women may be more emotionally expressive, they were not more reactive to aversive stimuli than men, as measured by emotional interference in a simple reaction time task.

  4. IAP/LASG全球海-陆-气耦合系统模式的纬向平均大气气候态分析%Analysis of the Zonal Mean Atmospheric Climate State in IAP/ LASG GOALS Model Simulations

    Institute of Scientific and Technical Information of China (English)

    张韬; 郭裕福; 吴国雄

    2002-01-01

    The results of four versions of IAP/LASG Global Ocean-Atmosphere-Land System Model (GOALS) are analyzed separately over the oceans and over continents, and compared with observed data.Some fundamental atmospheric variables including surface air temperature (SAT), sea level pressure (SLP) and precipitation are examined to evaluate the ability of the GOALS model to simulate the contemporary climate and climate variability. In general, all four versions of the GOALS model are capable of reproducing the main features of the mean state and seasonal variation of the observed climate with reasonable accuracy.The evaluation also reveals some weakness of the model. According to this study, we can clearly see that the essential discrepancy of global averaged SLP lies over the continents in boreal summer. The simulated higher SAT over land versus the observed is mainly due to the effect of the land surface process. It is worth noting the underestimation by simulated precipitation rates mostly appears over the oceans, yet over-land precipitation is higher in high and middle latitudes than the observed for the boreal winter.Through intercomparisons among different versions of the model, it can be clearly seen that the incorporation of the diurnal cycle of solar radiation apparently improves the simulation of SAT, especially in the low and middle latitudes over land. Also, the introduction of the diurnal cycle shows a great improvement in precipitation in tropical continents and wintertime precipitation in high and middle latitudes. Furthermore,based on the daily flux anomaly exchange scheme (DFA), the latest version of GOALS model simulated over-ocean temperature variability is improved in the low and middle latitudes.Having compared the standard deviation of the annual mean surface air temperature (SAT) simulated by the GOALS model to observation, it is found that all four versions of the GOALS model underestimate surface air temperature variability over both oceans and land

  5. Complexity: The bigger picture

    CERN Document Server

    Vicsek, Tamás

    2010-01-01

    If a concept is not well defined, there are grounds for its abuse. This is particularly true of complexity, an inherently interdisciplinary concept that has penetrated very different fields of intellectual activity from physics to linguistics, but with no underlying, unified theory. Complexity has become a popular buzzword used in the hope of gaining attention or funding -- institutes and research networks associated with complex systems grow like mushrooms. Why and how did it happen that this vague notion has become a central motif in modern science? Is it only a fashion, a kind of sociological phenomenon, or is it a sign of a changing paradigm of our perception of the laws of nature and of the approaches required to understand them? Because virtually every real system is inherently extremely complicated, to say that a system is complex is almost an empty statement - couldn't an Institute of Complex Systems just as well be called an Institute for Almost Everything? Despite these valid concerns, the world is ...

  6. Scanning bubble chamber pictures

    CERN Multimedia

    1974-01-01

    These were taken at the 2 m hydrogen bubble chamber. The photo shows an early Shiva system where the pre-measurements needed to qualify the event were done manually (cf photo 7408136X). The scanning tables were located in bld. 12. Gilberte Saulmier sits on foreground, Inge Arents at centre.

  7. Transcriptional and post-transcriptional regulation of retrotransposons IAP and MuERV-L affect pluripotency of mice ES cells

    Directory of Open Access Journals (Sweden)

    Pintado Belen

    2006-11-01

    Full Text Available Abstract Background In the mouse, culture of embryonic stem (ES cells may decrease their pluripotency and give rise to foetal abnormalities in recipient embryos. These abnormalities are frequently associated with both, chromosome abnormalities or epigenetic alteration of imprinting genes; however, little is known about the epigenetic stability of endogenous retrotransposable elements (REs. In our laboratory, we came across a R1 ES cell line, which at passage 27, lost the ability of germline transmission and started inducing the kinky tail phenotype in all chimeric animals produced with it. Methods In order to investigate whether this phenotype was associated with chromosome alteration, inadvertent differentiation, or epigenetic modification, we characterized and compared this R1 ES cell line at passage 27 with an early passage and with a second ES cell line C57/CBAF1 generated in our laboratory. We assessed: i karyotype; ii expression of pluripotent and differentiation markers, iii mRNA transcription by qRT-PCR of two REs, intracisternal-A particle (IAP and murine endogenous-retrovirus-L (MuERV-L, and iv methylation of IAP and MuERV-L. Results The R1 ES cell at passage 27, presented normal morphology, karyotype, and expression of genetic markers characteristic of pluripotent; however, it was detected an altered mRNA transcription of sense and antisense RNA strands of both REs, concomitantly with an altered methylation pattern for the IAP element but not for MuERV-L. These results indicate that besides methylation, other post-transcriptional processes are involved in gene silencing of some REs; and that culture of ES cells may decrease their pluripotency by producing inadvertent alterations in the expression of REs without significantly affecting the morphology, chromosome structure, and expression of pluripotent or differentiation markers. Conclusion Inadvertent REs instability may have important consequences for the use of ES cells in

  8. Snake pictures draw more early attention than spider pictures in non-phobic women: evidence from event-related brain potentials.

    Science.gov (United States)

    Van Strien, J W; Eijlers, R; Franken, I H A; Huijding, J

    2014-02-01

    Snakes were probably the first predators of mammals and may have been important agents of evolutionary changes in the primate visual system allowing rapid visual detection of fearful stimuli (Isbell, 2006). By means of early and late attention-related brain potentials, we examined the hypothesis that more early visual attention is automatically allocated to snakes than to spiders. To measure the early posterior negativity (EPN), 24 healthy, non-phobic women watched the random rapid serial presentation of 600 snake pictures, 600 spider pictures, and 600 bird pictures (three pictures per second). To measure the late positive potential (LPP), they also watched similar pictures (30 pictures per stimulus category) in a non-speeded presentation. The EPN amplitude was largest for snake pictures, intermediate for spider pictures and smallest for bird pictures. The LPP was significantly larger for both snake and spider pictures when compared to bird pictures. Interestingly, spider fear (as measured by a questionnaire) was associated with EPN amplitude for spider pictures, whereas snake fear was not associated with EPN amplitude for snake pictures. The results suggest that ancestral priorities modulate the early capture of visual attention and that early attention to snakes is more innate and independent of reported fear. Copyright © 2013 Elsevier B.V. All rights reserved.

  9. Reflexión metodológica sobre la aplicacion concreta de la Investigacion Accion Participativa (IAP en contextos rurales del estado de Colima

    Directory of Open Access Journals (Sweden)

    Ma. Guadalupe Chávez Méndez

    2003-01-01

    Full Text Available El objetivo de este documento es difundir información sobre el proceder metodológico de la Investigación Acción Participativa (IAP, con la finalidad de identificar necesidades reales que garanticen el diseño de estrategias de desarrollo sostenido. El texto plantea reflexiones teórico-metodológicas con relación a la aplicación concreta de la IAP en contextos rurales. Se genera información util para la acción en lo referente a la toma de decisiones técnicas al describir el proceso reflexivo generado a partir de observar cómo opera la IAP en contextos rurales del estado de Colima.

  10. Recurrent Overexpression of c-IAP2 in EBV-Associated Nasopharyngeal Carcinomas: Critical Role in Resistance to Toll-like Receptor 3-Mediated Apoptosis

    Directory of Open Access Journals (Sweden)

    Luc Friboulet

    2008-11-01

    Full Text Available The oncogenic process leading to nasopharyngeal carcinoma (NPC requires the combination of genetic and epigenetic alterations, latent infection by the Epstein-Barr virus and local inflammation. A transcriptome analysis of NPC xenografts identified the gene encoding the cellular inhibitor of apoptosis protein 2 (c-IAP2 among the top five most intensely expressed. Consistently, the very high levels of the c-IAP2 protein were detected in 11 of 13 NPC biopsies. RMT 5265, a structural analog of second mitochondria-derived activator of caspase (SMAC, induced the rapid degradation of c-IAP2 in nasopharyngeal epithelial cells, whether malignant or not, but blocked clonal cell growth in NPC cells only. In short-term experiments, RMT 5265 induced apoptosis in a fraction of NPC cells, and this apoptosis was dramatically enhanced when RMT 5265 was combined with Toll-like receptor 3 (TLR3 stimulation. By contrast, the cooperative effect with tumor necrosis factor α was only marginal. The apoptosis induced by the combination of RMT 5265 and TLR3 stimulation was mediated by caspase-8 and associated with a decrease in the cellular content of the long isoform of FLICE-like inhibitory protein. Similar caspase-8 activation was obtained when siRNA knockdown of c-IAP2 was combined with TLR3 stimulation. In conclusion, c-IAP2 has a specific protective function in NPC cells challenged by TLR3 agonists. This protective function is probably important to make NPC cells tolerant to their own production of small viral RNAs, which are potential agonists of TLR3. Our data will help to design a rational use of IAP inhibitors in NPC patients.

  11. The small-molecule IAP antagonist AT406 inhibits pancreatic cancer cells in vitro and in vivo

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Yongsheng; Meng, Qinghua [Department of General Surgery, Jinan Central Hospital of Shandong University, Jinan (China); Chen, Bo [Department of Biliary and Pancreatic Surgery, East Hospital Affiliated to Tongji University in Shanghai, Shanghai (China); Shen, Haiyu; Yan, Bing [Department of General Surgery, Jinan Central Hospital of Shandong University, Jinan (China); Sun, Baoyou, E-mail: sunbaoyou_sdu@yeah.net [Department of General Surgery, Shandong Provincial Hospital Affiliated to Shandong University, No.9677 Jing-Shi Road, Jinan 250014 (China)

    2016-09-09

    In the present study, we tested the anti-pancreatic cancer activity by AT406, a small-molecule antagonist of IAP (inhibitor of apoptosis proteins). In established (Panc-1 and Mia-PaCa-2 lines) and primary human pancreatic cancer cells, treatment of AT406 significantly inhibited cell survival and proliferation. Yet, same AT406 treatment was non-cytotoxic to pancreatic epithelial HPDE6c7 cells. AT406 increased caspase-3/-9 activity and provoked apoptosis in the pancreatic cancer cells. Reversely, AT406′ cytotoxicity in these cells was largely attenuated with pre-treatment of caspase inhibitors. AT406 treatment caused degradation of IAP family proteins (cIAP1 and XIAP) and release of cytochrome C, leaving Bcl-2 unaffected in pancreatic cancer cells. Bcl-2 inhibition (by ABT-737) or shRNA knockdown dramatically sensitized Panc-1 cells to AT406. In vivo, oral administration of AT406 at well-tolerated doses downregulated IAPs (cIAP1/XIAP) and inhibited Panc-1 xenograft tumor growth in severe combined immunodeficient (SCID) nude mice. Together, our preclinical results suggest that AT406 could be further evaluated as a promising anti-pancreatic cancer agent. - Highlights: • AT406 is cytotoxic to established/primary human pancreatic cancer cells. • AT406 provokes caspase-dependent apoptosis in pancreatic cancer cells. • AT406 causes degradation of key IAPs and promotes cytochrome C release. • Bcl-2 inhibition or knockdown dramatically sensitizes Panc-1 cells to AT406. • Oral administration of AT406 inhibits Panc-1 tumor growth in SCID nude mice.

  12. SOFTWARE SUPPORT FOR RICH PICTURES

    DEFF Research Database (Denmark)

    Valente, Andrea; Marchetti, Emanuela

    2010-01-01

    Rich pictures (RP) are common in object-oriented analysis and design courses, but students seem to have problems in integrating them in their projects' workflow. A new software tool is being developed, specific for RP authoring. To better understand students' issues and working practice with RP...

  13. The Picture of Dorian Gray

    NARCIS (Netherlands)

    Wilde, Oscar

    2005-01-01

    On its first publication The Picture of Dorian Gray was regarded as dangerously modern in its depiction of fin-de-sicle decadence. In this updated version of the Faust story, the tempter is Lord Henry Wotton, who lives selfishly for amoral pleasure; Dorian's good angel is the portrait painter Basil

  14. On the Color Dipole Picture

    CERN Document Server

    Schildknecht, Dieter

    2016-01-01

    We give a brief representation of the theoretical results from the color dipole picture, covering the total photoabsorption cross section, high-energy $J/\\psi$ photoproduction with respect to recent experimental data from the LHCb Collaboration at CERN, and ultra-high energy neutrino scattering, relevant for the ICE-CUBE experiment.

  15. The Picture of Dorian Gray

    NARCIS (Netherlands)

    Wilde, Oscar

    2005-01-01

    On its first publication The Picture of Dorian Gray was regarded as dangerously modern in its depiction of fin-de-sicle decadence. In this updated version of the Faust story, the tempter is Lord Henry Wotton, who lives selfishly for amoral pleasure; Dorian's good angel is the portrait painter Basil

  16. Malt1 and cIAP2-Malt1 as effectors of NF-κB activation: Kissing cousins or distant relatives?

    OpenAIRE

    Kingeter, Lara M.; Schaefer, Brian C.

    2009-01-01

    Malt1 is a multi-domain cytosolic signaling molecule that was originally identified as the target of recurrent translocations in a large fraction of MALT lymphomas. The product of this translocation is a chimeric protein in which the N-terminus is contributed by the apoptosis inhibitor, cIAP2, and the C-terminus is contributed by Malt1. Early studies suggested that Malt1 is an essential intermediate in antigen receptor activation of NF-κB, and that the juxtaposition of the cIAP2 N-terminus an...

  17. Bianisotropy Picture of Higher Permeability at Higher Frequencies

    Institute of Scientific and Technical Information of China (English)

    XUE De-Sheng; LI Fa-Shen; FAN Xiao-Long; WEN Fu-Sheng

    2008-01-01

    With an effective bianisotropy picture, high-frequency behaviours of different magnetic materials can be reconciled, and the higher permeability and higher resonance frequencies are achieved even in the GHz range. The validity of the bianisotropy picture is quantitatively refilled by the in-plane anisotropic Fe34Co55Zr11 thin films.A prolate elliptical precession of the magnetization about its equilibrium direction is the key point, which can be induced by an artificial or an intrinsic bianisotropy system.

  18. Do hospital physicians really want to go digital? Acceptance of a picture archiving and communication system in a university hospital; Moechten Krankenhausaerzte wirklich auf digitale Systeme umsteigen? Die Akzeptanz gegenueber einem Bildarchivierungs- und Uebermittlungssystem in einer Universitaetsklinik

    Energy Technology Data Exchange (ETDEWEB)

    Duyck, P.; Pynoo, B.; Devolder, P.; Voet, T.; Adang, L.; Vercruysse, J. [Radiologie und medizinische Bildgebung, Universitaetsklinik Gent (Belgium)

    2008-07-15

    Purpose: radiology departments are making the transition from analog film to digital images by means of PACS (Picture Archiving and Communication System). It is critical for the hospital that its physicians adopt and accept the new digital work method regarding radiological information. The aim of this study is to investigate hospital physicians' acceptance of PACS using questionnaires pre- and post-implementation and to identify main influencing factors. Materials and methods: the study was conducted in an 1169 bed university hospital. The UTAUT (Unified Theory of Acceptance and Use of Technology) questionnaire was administered at two times: one month pre-implementation (T1) and 1.5 years post-implementation (T2) of PACS, targeting all hospital physicians with the exemption of radiologists. The UTAUT scales (Behavioral Intention BI; Facilitating Conditions FC; Effort Expectancy EE; Performance Expectancy PE; Anxiety ANX; Social Influence SI; System Use USE; Attitude toward technology ATT; Self-Efficacy SE) were used to assess questions regarding: (a) PACS' usefulness, (b) PACS' ease of learning/using, (c) PACS support availability, (d) the perceived pressure to use PACS, (e) physicians' attitude towards PACS and (f) physicians' intention to use and actual use of PACS. Results: at T1 scale ratings were positive toward the PACS implementation. The ratings on all scales with the exception of self-efficacy improved at T2. Regression analysis revealed that the key factor for intention to use PACS at T1 was the usefulness of PACS, while the availability and awareness of support was its most important predictor at T2. Overall, PE was the best predictor of BI, but all four UTAUT-determinants (PE, FC, EE and SI) were salient for its prediction. Variance explained in BI ranged from 31 to 37% while variance explained in USE was very low (3%). (orig.)

  19. A Picture of My Family

    Institute of Scientific and Technical Information of China (English)

    阳习周

    2008-01-01

    My name is Yang Xizhou.I’m a Chinese boy.I am thirteen.This isa picture of my family at home.It’s an old photo of my family.You cansee my father,my mother,my sister and I.We all look young because wetake①it five years ago.I was eight years old that year.

  20. Statistical Inference: The Big Picture.

    Science.gov (United States)

    Kass, Robert E

    2011-02-01

    Statistics has moved beyond the frequentist-Bayesian controversies of the past. Where does this leave our ability to interpret results? I suggest that a philosophy compatible with statistical practice, labelled here statistical pragmatism, serves as a foundation for inference. Statistical pragmatism is inclusive and emphasizes the assumptions that connect statistical models with observed data. I argue that introductory courses often mis-characterize the process of statistical inference and I propose an alternative "big picture" depiction.

  1. Teaching beginner ELLs using picture books tellability

    CERN Document Server

    Lado, Ana L (Luisa)

    2012-01-01

    Picture your beginning ELLs reading their way to success! For beginning ELLs, a picture really is worth a thousand words! Picture books are useful tools for building important language and social foundations that students may miss through traditional instruction. Ana Lado provides all the tools you'll need to engage ELLs of any age with picture books, including how to: Design lessons around picture books Select appropriate titles using specific criteria Incorporate fun and engaging strategies like singing and reenacting Access the book's searchable online database to find the right book Integrate picture-book learning to facilitate development of English Language Proficiency.

  2. Tradução, adaptação transcultural e evidências de validade da escala improvisation assessment profiles (IAPs) para uso no Brasil

    DEFF Research Database (Denmark)

    Gattino, Gustavo; Ferrari, Karina; Azevedo, Graciane

    2016-01-01

    This article is intended to present the second part of the research which created the Improvisation Assessment Profiles (IAPs) version in Brazil according to a formal translation process and the analysis of the instrument in relation to its cross-cultural adaptation. The scale was also evaluated ...

  3. 中医远程医学网中舌象分析系统的设计研究%Study on Designing of Tele-analysis of Tongue Picture System for TCM

    Institute of Scientific and Technical Information of China (English)

    徐公明; 马志庆; 柳澄; 郝莲花

    2011-01-01

    Objective: To design an tongue picture analysis system for telemedicine of traditional Chinese medicine. Method: We showed the features and advantages of the te]emedicine which.simulates the socia/and geographical environments, basing on the theory of traditional Chinese medicine, then analyzed the key technology of tongue picture analysis, finally, designed the new system. Result: The newly designed system costs less and was practical and was adapted to telemedieine, characterized by traditional Chinese medicine. Conclusion: These new system and new telemedicine provides a new idea for the development of diagnosis, and have a good prospect for applying.%目的:设计能够应用于面向家庭的中医特色远程医学网的舌象分析系统.方法:结合模拟古代地理和社会环境的中医远程医学网的特点与优势,总结实现中医舌象分析的关键技术要求,设计远程化的舌象分析系统.结果:新型的舌象分析系统具有成本低,实用化的特点,适合在中医远程医学网中应用.结论:新型的舌象分析系统及中医远程医学网的设计为网络环境下中医诊疗的发展提供了一种很好的思路,并且具有很好的应用前景.

  4. Numerical Simulation of Global Temperature Change during the 20th Century with the IAP/LASG GOALS Model

    Institute of Scientific and Technical Information of China (English)

    马晓燕; 郭裕福; 石广玉; 俞永强

    2004-01-01

    The IAP/LASG GOALS coupled model is used to simulate the climate change during the 20th century using historical greenhouse gases concentrations, the mass mixing ratio of sulfate aerosols simulated by a CTM model, and reconstruction of solar variability spanning the period 1900 to 1997. Four simulations,including a control simulation and three forcing simulations, are conducted. Comparison with the observational record for the period indicates that the three forcing experiments simulate reasonable temporal and spatial distributions of the temperature change. The global warming during the 20th century is caused mainly by increasing greenhouse gas concentration especially since the late 1980s; sulfate aerosols offset a portion of the global warming and the reduction of global temperature is up to about 0.11°C over the century; additionally, the effect of solar variability is not negligible in the simulation of climate change over the 20th century.

  5. Don Muang IAP, Bangkok, Thailand. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F

    Science.gov (United States)

    1971-04-02

    00,10 10. 0.09, M0.±0.1k., 0..D.’ 0 J AQf 100 98,4100, 00.0100. 100.01001 00. 100,0100,0100, 100.0 00,0 00,o000.0100.0 2: 0 so .00100 1 100,1000 20...SUMMARYOP SURFACE WEATHER OSEAYATM BANGKOK THAILAND/DON WUANG IAP W8ANO 41001 N 13 55 E 100 36 ELEV 33 FT VTOD WMOE 46436 PARTS A-F POR FROM HOURLY OBS JAN...LOCATION STION FROM TO STATIONIrr) BAROMETER DAY 0I Don uang Apt, Thailand /TAF Jan 54 Dee 63 N 13 55 E 100 36 33 39 Ft 24 LOCATION CHANACTEI LOCATION

  6. Malt1 and cIAP2-Malt1 as effectors of NF-kappaB activation: kissing cousins or distant relatives?

    Science.gov (United States)

    Kingeter, Lara M; Schaefer, Brian C

    2010-01-01

    Malt1 is a multi-domain cytosolic signaling molecule that was originally identified as the target of recurrent translocations in a large fraction of MALT lymphomas. The product of this translocation is a chimeric protein in which the N-terminus is contributed by the apoptosis inhibitor, cIAP2, and the C-terminus is contributed by Malt1. Early studies suggested that Malt1 is an essential intermediate in antigen receptor activation of NF-kappaB, and that the juxtaposition of the cIAP2 N-terminus and the Malt1 C-terminus results in deregulation of Malt1 NF-kappaB stimulatory activity. Initial experimental data further suggested that the molecular mechanisms of Malt1- and cIAP-Malt1-mediated NF-kappaB activation were quite similar. However, a number of more recent studies of both Malt1 and cIAP2-Malt1 now reveal that these proteins influence NF-kappaB activation by multiple distinct mechanisms, several of which are non-overlapping. Currently available data suggest a revised model in which cIAP2-Malt1 induces NF-kappaB activation via a mechanism that depends equally on domains contributed by cIAP2 and Malt1, which confer spontaneous oligomerization activity, polyubiquitin binding, proteolytic activity, and association with and activation of TRAF2 and TRAF6 at several independent binding sites. By contrast, emerging data suggest that the wild-type Malt1 protein uniquely contributes to NF-kappaB activation primarily through the control of two proteolytic cleavage mechanisms. Firstly, Malt1 directly cleaves and inactivates A20, a negative regulator of the antigen receptor-to-NF-kappaB pathway. Secondly, Malt1 interacts with caspase-8, inducing caspase-8 cleavage of c-FLIP(L), initiating a pathway that contributes to activation of the I kappaB kinase (IKK) complex. Furthermore, data suggest that Malt1 plays a more limited and focused role in antigen receptor activation of NF-kappaB, serving to augment weak antigen signals and stimulate a defined subset of NF

  7. Brassinosteroid signal transduction: An emerging picture

    Institute of Scientific and Technical Information of China (English)

    WANG Qiaomei; MA Ligeng

    2003-01-01

    Steroid hormones play essential roles in animal growth and development. Steroid signaling in animal system is focused on the direct gene regulation response mediated by its nuclear receptors. Recently, steroid hormones are also found in plants. Identification of BRI1 - a critical component of the plasma-membrane steroid receptor complex, and the related signal transduction pathway mediated by the membrane receptor have revealed an elementary picture of BR signaling from the cell surface perception to the activation of BR-responsive nuclear genes.

  8. Climate Change Projections for the 21st Century by the NCC/IAP T63 Model with SRES Scenarios

    Institute of Scientific and Technical Information of China (English)

    XU Ying; ZHAO Zongci; LUO Yong; GAO Xuejie

    2005-01-01

    The projections of climate change in the globe and East Asia by the NCC/IAP T63 model with the SRES A2 and A1B scenarios have been investigated in this paper. The results pointed out a global warming of 3.6℃/100 yr and 2.5℃/100 yr for A2 and A1B during the 21st century, respectively. The warming in high and middle latitudes will be more obvious than that in low latitudes, especially in the winter hemisphere.The warming of 5.1℃/100 yr for A2 and 3.6℃/100 yr for A1B over East Asia in the 21st century will be much higher than that in the globe. The global mean precipitation will increase by about 4.3%/100 yr for A2 and 3.4%/100 yr for A1B in the 21st century, respectively. The precipitation will increase in most parts of the low and high latitudes and decrease in some regions of the subtropical latitudes. The linear trends of the annual mean precipitation anomalies over East Asia will be 9.8%/100 yr for A2 and 5.2%/100 yr for A1B, respectively. The drier situations will occur over the northwestern and southeastern parts of East Asia.The changes of the annual mean temperature and precipitation in the globe for the 21st century by the NCC/IAP T63 model with SRES A2 and A1B scenarios are in agreement with a number of the model projections.

  9. A Study on Sulfate Optical Properties and Direct Radiative Forcing Using LASG-IAP General Circulation Model

    Institute of Scientific and Technical Information of China (English)

    LI Jiandong; Zhian SUN; LIU Yimin; Jiangnan LI; Wei-Chyung WANG; WU Guoxiong

    2012-01-01

    The direct radiative forcing (DRF) of sulfate aerosols depends highly on the atmospheric sulfate loading and the meteorology,both of which undergo strong regional and seasonal variations.Because the optical properties of sulfate aerosols are also sensitive to atmospheric relative humidity,in this study we first examine the scheme for optical properties that considers hydroscopic growth.Next,we investigate the seasonal and regional distributions of sulfate DRF using the sulfate loading simulated from NCAR CAM-Chem together with the meteorology modeled from a spectral atmospheric general circulation model (AGCM) developed by LASG-IAP.The global annual-mean sulfate loading of 3.44 mg m -2 is calculated to yield the DRF of -1.03and -0.57 W m-2 for clear-sky and all-sky conditions,respectively.However,much larger values occur on regional bases.For example,the maximum all-sky sulfate DRF over Europe,East Asia,and North America can be up to -4.0 W m-2.The strongest all-sky sulfate DRF occurs in the Northern Hemispheric July,with a hemispheric average of -1.26 W m-2.The study results also indicate that the regional DRF are strongly affected by cloud and relative humidity,which vary considerably among the regions during different seasons.This certainly raises the issue that the biases in model-simulated regional meteorology can introduce biases into the sulfate DRF.Hence,the model processes associated with atmospheric humidity and cloud physics should be modified in great depth to improve the simulations of the LASG-IAP AGCM and to reduce the uncertainty of sulfate direct effects on global and regional climate in these simulations.

  10. 基于PACS医学影像数字化教学平台的构建和应用%Construction and application of picture archiving and communication system based on digital teaching platform of medical imaging

    Institute of Scientific and Technical Information of China (English)

    邹利光; 张冬; 戚跃勇; 周宇; 张启川

    2012-01-01

    基于图像存档与传输系统( PACS)医学影像数字化教学平台由医学影像网络教学系统和医学影像教学资源库两部分组成.医学影像网络教学系统包括课堂管理、作业管理、教学管理和考试管理4大功能模块.医学影像教学资源库包括理论教材、典型病例、检查技术方法和医学影像设备的文字、图片、音频、视频、动画资料等.通过在理论课和阅片训练实践课教学中的应用,凸显了医学影像学教学的特点,发挥了学生学习的主观能动性.%Picture archiving and communication system ( PACS ) based on digital teaching platform of medical imaging consists of web teaching system and teaching resource library of medical imaging.The web teaching system includes four function modules of classroom management,work management,teaching management and test management.The teaching resource library includes script,pictures,and audio,video and animation materials of theoretical books,typical cases,examination techniques and medical imaging equipments.Utilized in theoretical and practical classes,the teaching characteristic of medical imaging is made prominent,and the subjective motility of the students is brought into play.

  11. A Picture of Subsidized Households 2009

    Data.gov (United States)

    Department of Housing and Urban Development — Picture of Subsidized Households describes the nearly 5 million households living in HUD-subsidized housing in the United States for the year 2009. Picture 2009...

  12. A Picture of Subsidized Housholds 2008

    Data.gov (United States)

    Department of Housing and Urban Development — Picture of Subsidized Households describes the nearly 5 million households living in HUD-subsidized housing in the United States for the year 2008. Picture 2008...

  13. Implantação de um mini-pacs (sistema de arquivamento e distribuição de imagens em hospital universitário Mini-PACS (picture archiving and communication system implementation at a university hospital

    Directory of Open Access Journals (Sweden)

    Paulo Mazzoncini de Azevedo-Marques

    2001-08-01

    Full Text Available Este trabalho apresenta a implementação de um mini-PACS (sistema de arquivamento e comunicação de imagens que está sendo estruturado junto ao Serviço de Radiodiagnóstico do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, como parte do projeto de um serviço de radiologia digital ("filmless".This paper describes the implementation of a mini-PACS (picture archiving and communication system at a university hospital ("Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo", as a component of a project for a filmless radiology facility.

  14. Text-Picture Relations in Cooking Instructions

    NARCIS (Netherlands)

    van der Sluis, Ielka; Leito, Shadira; Redeker, Gisela; Bunt, Harry

    2016-01-01

    Like many other instructions, recipes on packages with ready-to-use ingredients for a dish combine a series of pictures with short text paragraphs. The information presentation in such multimodal instructions can be compact (either text or picture) and/or cohesive (text and picture). In an explorato

  15. 32 CFR 705.8 - Motion pictures.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Motion pictures. 705.8 Section 705.8 National... OFFICIAL RECORDS PUBLIC AFFAIRS REGULATIONS § 705.8 Motion pictures. (a) The rules and procedures given in the preceding for TV will also apply to cooperation with commercial motion picture producers. (b)...

  16. Sweat equity: a team approach to designing a new technology:customer-driven design of a picture archiving and communications systems (PACS) that works

    Science.gov (United States)

    Gelish, Anthony; Wright, Linda C.

    1994-05-01

    This paper defines the roles of customers and suppliers, customer variables, and customer contributions to the system creation process, discusses expected outcomes for a customer- driven system development process, and illustrates how this approach was used in the development of digital radiology.

  17. Liquid Crystal Motion Picture Projector①

    Institute of Scientific and Technical Information of China (English)

    SHIYongji

    1997-01-01

    A liquid crystal moving picture projector and method are described.Light incident on a liquid crystal display-type device is selectively scattered or transmitted by respective portions of liquid crystal display,and a projection mechanism projects an image formed by either such scattered light or such transmitted light.A liquid cystal moving picture projector includes a liquid crystal display for creating characteristics of an image,and projecttion optics for projecting images sequentially created by the display.The display includes a liquid crystal material capable of temporary storing information at respective areas.The temporary storage may be a function of charge storing directly on liquid crystal material.A method of projecting plural images in sequence includes:creating an image or characteristics of an image in a liquid crystal material,storing such image in such liquid crystal material,directing light at such liquid crystal material,projecting such image as a function of light transmitted through or scattered by such liquid crystal material,and creating a further image in such liquid crystal material for subsequent projection.

  18. Brain Potentials During Affective Picture Processing in Children

    Science.gov (United States)

    Hajcak, Greg; Dennis, Tracy A.

    2008-01-01

    In adults, emotional (e.g., both unpleasant and pleasant) compared to neutral pictures elicit an increase in the early posterior negativity (EPN) and the late positive potential (LPP); modulation of these ERP components are thought to reflect the facilitated processing of, and increased attention to, motivationally salient stimuli. To determine whether the EPN and LPP are sensitive to emotional content in children, high-density EEG was recorded from 18 children who were 5 to 8 years of age (mean age = 77 months, SD = 11 months) while they viewed developmentally appropriate pictures selected from the International Affective Picture System. Self-reported ratings of valence and arousal were also obtained. An EPN was not evident following emotional compared to neutral pictures; however, a positivity maximal at occipital-parietal recording sites was increased from 500 to 1,000 ms following pleasant pictures and from 500 to 1,500 ms following unpleasant pictures. Comparisons between the EPN and LPP observed in children and adults, and implications for developmental studies of emotion, are discussed. PMID:19103249

  19. Recommendations of 2nd National Consultative Meeting of Indian Academy of Pediatrics (IAP) on polio eradication and improvement of routine immunization.

    Science.gov (United States)

    Vashishtha, Vipin M; Kalra, Ajay; John, T Jacob; Thacker, Naveen; Agarwal, R K

    2008-05-01

    Persistence of intense wild poliovirus (WPV) transmission, particularly type 3 in northern India necessitated the Indian Academy of Pediatrics (IAP) to convene a National Consultative Meeting to review its earlier recommendations on polio eradication and improvement of routine immunization. More than thirty experts were invited and intense deliberations were held over two days to draw consensus statements on various issues related with polio eradication. To review the ongoing strategy, identify the existing challenges, and suggest modifications to the current strategy for eradication of poliomyelitis in India. IAP reiterates its support to ongoing efforts on polio eradication but demand some flexibility in the strategy. The immediate challenges identified include persistent WPV type 1 transmission in Uttar Pradesh (UP) and Bihar, intense type 3 transmission also in UP and Bihar, and maintaining polio-free status of all other states. Circulating vaccine derived poliovirus (cVDPV), particularly type 2, was identified as a great future threat. Neglect of routine immunization (RI), poor efficacy of oral polio vaccine (OPV), operational issues, and inadequate uptake of OPV in the 2 endemic states are the main reasons of failure to interrupt transmission of WPV 1 and 3. However, for the first time in history the intensity of WPV 1 circulation is very low in western UP. IAP suggests that high-quality, uniform and consistent performance of supplementary immunization activities (SIAs) in all districts of western UP, particularly using mOPV1(monovalent OPV1) should be maintained to avoid reestablishment of circulation of type 1 poliovirus. A judicious mix of mOPV1 and mOPV3, given sequentially or even simultaneously (after validating the efficacies) will be necessary to address the upsurge of WPV3. Re-establishing routine immunization should be the foremost priority. IAP strongly recommends to Government of India (GOI) to take urgent measures to attain coverage of a minimum

  20. Motor mapping of implied actions during perception of emotional body language

    NARCIS (Netherlands)

    Borgomaneri, Sara; Gazzola, Valeria; Avenanti, Alessio

    Background: Perceiving and understanding emotional cues is critical for survival. Using the International Affective Picture System (IAPS) previous TMS studies have found that watching humans in emotional pictures increases motor excitability relative to seeing landscapes or household objects,

  1. Motor mapping of implied actions during perception of emotional body language

    NARCIS (Netherlands)

    Borgomaneri, Sara; Gazzola, Valeria; Avenanti, Alessio

    2012-01-01

    Background: Perceiving and understanding emotional cues is critical for survival. Using the International Affective Picture System (IAPS) previous TMS studies have found that watching humans in emotional pictures increases motor excitability relative to seeing landscapes or household objects, sugges

  2. Testing the snake-detection hypothesis: larger early posterior negativity in humans to pictures of snakes than to pictures of other reptiles, spiders and slugs.

    Science.gov (United States)

    Van Strien, Jan W; Franken, Ingmar H A; Huijding, Jorg

    2014-01-01

    According to the snake detection hypothesis (Isbell, 2006), fear specifically of snakes may have pushed evolutionary changes in the primate visual system allowing pre-attentional visual detection of fearful stimuli. A previous study demonstrated that snake pictures, when compared to spiders or bird pictures, draw more early attention as reflected by larger early posterior negativity (EPN). Here we report two studies that further tested the snake detection hypothesis. In Study 1, we tested whether the enlarged EPN is specific for snakes or also generalizes to other reptiles. Twenty-four healthy, non-phobic women watched the random rapid serial presentation of snake, crocodile, and turtle pictures. The EPN was scored as the mean activity at occipital electrodes (PO3, O1, Oz, PO4, O2) in the 225-300 ms time window after picture onset. The EPN was significantly larger for snake pictures than for pictures of the other reptiles. In Study 2, we tested whether disgust plays a role in the modulation of the EPN and whether preferential processing of snakes also can be found in men. 12 men and 12 women watched snake, spider, and slug pictures. Both men and women exhibited the largest EPN amplitudes to snake pictures, intermediate amplitudes to spider pictures and the smallest amplitudes to slug pictures. Disgust ratings were not associated with EPN amplitudes. The results replicate previous findings and suggest that ancestral priorities modulate the early capture of visual attention.

  3. Testing the snake-detection hypothesis: Larger early posterior negativity in humans to pictures of snakes than to pictures of other reptiles, spiders and slugs.

    Directory of Open Access Journals (Sweden)

    Jan W. Van Strien

    2014-09-01

    Full Text Available According to the snake detection hypothesis (Isbell, 2006, fear specifically of snakes may have pushed evolutionary changes in the primate visual system allowing pre-attentional visual detection of fearful stimuli. A previous study demonstrated that snake pictures, when compared to spiders or bird pictures, draw more early attention as reflected by larger early posterior negativity (EPN. Here we report two studies that further tested the snake detection hypothesis. In Study, 1 we tested whether the enlarged EPN is specific for snakes or also generalizes to other reptiles. Twenty-four healthy, non-phobic women watched the random rapid serial presentation of snake, crocodile, and turtle pictures. The EPN was scored as the mean activity at occipital electrodes (PO3, O1, Oz, PO4, O2 in the 225–300 ms time window after picture onset. The EPN was significantly larger for snake pictures than for pictures of the other reptiles. In study 2, we tested whether disgust plays a role in the modulation of the EPN and whether preferential processing of snakes also can be found in men. Twelve men and twelve women watched snake, spider, and slug pictures. Both men and women exhibited the largest EPN amplitudes to snake pictures, intermediate amplitudes to spider pictures and the smallest amplitudes to slug pictures. Disgust ratings were not associated with EPN amplitudes. The results replicate previous findings and suggest that ancestral priorities modulate the early capture of visual attention.

  4. Testing the snake-detection hypothesis: larger early posterior negativity in humans to pictures of snakes than to pictures of other reptiles, spiders and slugs

    Science.gov (United States)

    Van Strien, Jan W.; Franken, Ingmar H. A.; Huijding, Jorg

    2014-01-01

    According to the snake detection hypothesis (Isbell, 2006), fear specifically of snakes may have pushed evolutionary changes in the primate visual system allowing pre-attentional visual detection of fearful stimuli. A previous study demonstrated that snake pictures, when compared to spiders or bird pictures, draw more early attention as reflected by larger early posterior negativity (EPN). Here we report two studies that further tested the snake detection hypothesis. In Study 1, we tested whether the enlarged EPN is specific for snakes or also generalizes to other reptiles. Twenty-four healthy, non-phobic women watched the random rapid serial presentation of snake, crocodile, and turtle pictures. The EPN was scored as the mean activity at occipital electrodes (PO3, O1, Oz, PO4, O2) in the 225–300 ms time window after picture onset. The EPN was significantly larger for snake pictures than for pictures of the other reptiles. In Study 2, we tested whether disgust plays a role in the modulation of the EPN and whether preferential processing of snakes also can be found in men. 12 men and 12 women watched snake, spider, and slug pictures. Both men and women exhibited the largest EPN amplitudes to snake pictures, intermediate amplitudes to spider pictures and the smallest amplitudes to slug pictures. Disgust ratings were not associated with EPN amplitudes. The results replicate previous findings and suggest that ancestral priorities modulate the early capture of visual attention. PMID:25237303

  5. Decreased pain perception by unconscious emotional pictures

    Directory of Open Access Journals (Sweden)

    Irene Peláez

    2016-10-01

    Full Text Available Pain perception arises from a complex interaction between a nociceptive stimulus and different emotional and cognitive factors, which appear to be mediated by both automatic and controlled systems. Previous evidence has shown that whereas conscious processing of unpleasant stimuli enhances pain perception, emotional influences on pain under unaware conditions are much less known. The aim of the present study was to investigate the modulation of pain perception by unconscious emotional pictures through an emotional masking paradigm. Two kinds of both somatosensory (painful and non-painful and emotional stimulation (negative and neutral pictures were employed. Fifty pain-free participants were asked to rate the perception of pain they were feeling in response to laser-induced somatosensory stimuli as faster as they can. Data from pain intensity and reaction times were measured. Statistical analyses revealed a significant effect for the interaction between pain and emotional stimulation, but surprisingly this relationship was opposite to expected. In particular, lower pain intensity scores and longer reaction times were found in response to negative images being strengthened this effect for painful stimulation. Present findings suggest a clear pain perception modulation by unconscious emotional contexts. Attentional capture mechanisms triggered by unaware negative stimulation could explain this phenomenon leading to a withdrawal of processing resources from pain.

  6. Erotic and disgust-inducing pictures--differences in the hemodynamic responses of the brain.

    Science.gov (United States)

    Stark, Rudolf; Schienle, Anne; Girod, Cornelia; Walter, Bertram; Kirsch, Peter; Blecker, Carlo; Ott, Ulrich; Schäfer, Axel; Sammer, Gebhard; Zimmermann, Mark; Vaitl, Dieter

    2005-09-01

    The aim of this fMRI study was to explore brain structures that are involved in the processing of erotic and disgust-inducing pictures. The stimuli were chosen to trigger approach and withdrawal tendencies, respectively. By adding sadomasochistic (SM) scenes to the design and examining 12 subjects with and 12 subjects without sadomasochistic preferences, we introduced a picture category that induced erotic pleasure in one sample and disgust in the other sample. Since we also presented neutral pictures, all subjects viewed pictures of four different categories: neutral, disgust-inducing, erotic, and SM erotic pictures. The analysis indicated that several brain structures are commonly involved in the processing of disgust-inducing and erotic pictures (occipital cortex, hippocampus, thalamus, and the amygdala). The ventral striatum was specifically activated when subjects saw highly sexually arousing pictures. This indicates the involvement of the human reward system during the processing of visual erotica.

  7. Enhanced UK teletext moves towards still pictures

    Science.gov (United States)

    Chambers, J. P.

    1980-06-01

    Methods are proposed for the enhancement of the UK teletext system leading towards a high-definition still picture capability in addition to row of text and mozaic graphics. A teletext system is described wherein binary code groups are formed into data-lines for inclusion in the television field blanking interval. The control and address information carried on each dataline, together with the special page-header data-lines and the sequence of transmission of the data-lines, allow the data-lines corresponding to the rows of a selected page to be identified. The page structure can be used to send information other than pages of text. Certain data-lines can be used for functions unrelated to teletext. In addition, techniques utilizing a multipage store are examined for improving access; and teh extension of the character repertoire to enhance multilanguage capabilities is addressed.

  8. Aerial projection of three-dimensional motion pictures by electro-holography and parabolic mirrors

    OpenAIRE

    Takashi Kakue; Takashi Nishitsuji; Tetsuya Kawashima; Keisuke Suzuki; Tomoyoshi Shimobaba; Tomoyoshi Ito

    2015-01-01

    We demonstrate an aerial projection system for reconstructing 3D motion pictures based on holography. The system consists of an optical source, a spatial light modulator corresponding to a display and two parabolic mirrors. The spatial light modulator displays holograms calculated by computer and can reconstruct holographic motion pictures near the surface of the modulator. The two parabolic mirrors can project floating 3D images of the motion pictures formed by the spatial light modulator wi...

  9. Comparative Study of Sustained Attentional Bias on Emotional Processing in ADHD Children to Pictures with Eye-Tracking

    Directory of Open Access Journals (Sweden)

    Ebrahim PISHYAREH

    2015-01-01

    Full Text Available How to Cite This Article: Pishyareh E, Tehrani-doost M, Mahmoodi-gharaie J, Khorrami A, Rahmdar SR. A Comparative Study of SustainedAttentional Bias on Emotional Processing in ADHD Children to Pictures with Eye-Tracking. Iran J Child Neurol. 2015 Winter;9(1:64-70.AbstractObjectiveADHD children have anomalous and negative behavior especially in emotionally related fields when compared to other. Evidence indicates that attention has an impact on emotional processing. The present study evaluates the effect of emotional processing on the sustained attention of children with ADHD type C.Materials & Methods Sixty participants form two equal groups (each with 30 children of normal and ADHD children and each subject met the required selected criterion as either a normal or an ADHD child. Both groups were aged from 6–11-years-old. All pictures were chosen from the International Affective Picture System (IAPS and presented paired emotional and neutral scenes in the following categories: pleasant-neutral; pleasant-unpleasant; unpleasant-neutral; and neutral–neutral. Sustained attention was evaluated based on the number and duration of total fixation and was compared between the groups with MANOVA analysis.ResultsThe duration of sustained attention on pleasant in the pleasant-unpleasant pair was significant. Bias in duration of sustained attention on pleasant scenes in pleasant-neutral pairs is significantly different between the groups.ConclusionSuch significant differences might be indicative of ADHD children deficiencies in emotional processing. It seems that the highly deep effect of emotionally unpleasant scenes to gain the focus of ADHD children’s attention is responsible for impulsiveness and abnormal processing of emotional stimuli. References1. Sadock, B.J., H.I. Kaplan, and V.A. Sadock, Kaplan & Sadcok’s Synopsis of Psychiatry: Behavioral Sciences, Clinical Psychiatry. Lippincott; Williams & Wilkins. 2003.2. Cormier, E., Attention deficit

  10. Partial Enteral Nutrition Preserves Elements of Gut Barrier Function, Including Innate Immunity, Intestinal Alkaline Phosphatase (IAP) Level, and Intestinal Microbiota in Mice.

    Science.gov (United States)

    Wan, Xiao; Bi, Jingcheng; Gao, Xuejin; Tian, Feng; Wang, Xinying; Li, Ning; Li, Jieshou

    2015-08-03

    Lack of enteral nutrition (EN) during parenteral nutrition (PN) leads to higher incidence of infection because of gut barrier dysfunction. However, the effects of partial EN on intestina linnate immunity, intestinal alkaline phosphatase (IAP) and microbiota remain unclear. The mice were randomized into six groups to receive either standard chow or isocaloric and isonitrogenous nutritional support with variable partial EN to PN ratios. Five days later, the mice were sacrificed and tissue samples were collected. Bacterial translocation, the levels of lysozyme, mucin 2 (MUC2), and IAP were analyzed. The composition of intestinal microbiota was analyzed by 16S rRNA pyrosequencing. Compared with chow, total parenteral nutrition (TPN) resulted in a dysfunctional mucosal barrier, as evidenced by increased bacterial translocation (p microbiota (p intestinal microbiota.

  11. MicroRNA-34a inhibits tumor invasion and metastasis in osteosarcoma partly by effecting C-IAP2 and Bcl-2.

    Science.gov (United States)

    Wen, Jie; Zhao, Yan-Kun; Liu, Yan; Zhao, Jin-Feng

    2017-06-01

    Osteosarcoma is a common primary malignant bone tumor that occurs mainly in children and adolescents. Recent evidence has demonstrated that miR-34a is involved in the invasion and metastasis of osteosarcoma. This study aims to explore the effect of biological behavior of miR-34a on osteosarcoma. First, we collect osteosarcoma and adjacent specimens, and the relative expression of miR-34a and C-IAP2 messenger RNA was quantitated by real-time polymerase chain reaction. Furthermore, miR-34a stimulant is synthesized and transfected onto osteosarcoma MG-63 cells. The effect of overexpression of miR-34a on osteosarcoma was detected by colony-forming assay, Annexin V-fluorescein isothiocyanate Apoptosis Detection Kit I, Transwell assay, and animal experiment in vivo. Finally, the relative levels of C-IAP2 and Bcl-2 protein were checked by western blot, and the activity of caspase-3 and caspase-9 was tested by spectrophotometry assay. In conclusion, miR-34a was downregulated in osteosarcoma cells. And the expression of C-IAP2 and Bcl-2 protein was drastically inhibited, and the activities of caspase-3 and caspase-9 were significantly increased after transfecting miR-34a onto osteosarcoma MG-63 cells. And the overexpression of miR-34a can inhibit cell invasion and metastasis, promote cell apoptosis, and arrest cells in G0/G1 period. And the animal experiment in vivo demonstrated that the overexpression of miR-34a could significantly inhibit the growth of osteosarcoma in animal skin. Taken together, we indicated that miR-34a can inhibit tumor invasion and metastasis in osteosarcoma, and its mechanism may be partly related to downregulating the expression of C-IAP2 and Bcl-2 protein directly or indirectly.

  12. The cytoplasmic nuclear receptor RARγ controls RIP1 initiated cell death when cIAP activity is inhibited.

    Science.gov (United States)

    Xu, Qing; Jitkaew, Siriporn; Choksi, Swati; Kadigamuwa, Chamila; Qu, Jianhui; Choe, Moran; Jang, Jonathan; Liu, Chengyu; Liu, Zheng-Gang

    2017-09-04

    Tumor necrosis factor (TNF) has a critical role in diverse cellular events including inflammation, apoptosis and necroptosis through different signaling complexes. However, little is known about how the transition from inflammatory signaling to the engagement of death pathways is modulated. Here we report that the cytoplasmic retinoic acid receptor gamma (RARγ) controls receptor-interacting protein kinase 1 (RIP1)-initiated cell death when cellular inhibitor of apoptosis (cIAP) activity is blocked. Through screening a short hairpin RNA library, we found that RARγ was essential for TNF-induced RIP1-initiated apoptosis and necroptosis. Our data suggests that RARγ initiates the formation of death signaling complexes by mediating RIP1 dissociation from TNF receptor 1. We demonstrate that RARγ is released from the nucleus to orchestrate the formation of the cytosolic death complexes. In addition, we demonstrate that RARγ has a similar role in TNF-induced necroptosis in vivo. Thus, our study suggests that nuclear receptor RARγ provides a key checkpoint for the transition from life to death.The molecular switch between how tumour necrosis factor (TNF) controls inflammation versus cell death is less well defined. Here, the authors show that the nuclear receptor retinoic acid receptor gamma is released from the nucleus to disrupt TNF initiated cell death complexes in the cytoplasm.

  13. Topoisomerase degradation, DSB repair, p53 and IAPs in cancer cell resistance to camptothecin-like topoisomerase I inhibitors.

    Science.gov (United States)

    Tomicic, Maja T; Kaina, Bernd

    2013-01-01

    Topoisomerase I (TOP1) inhibitors applied in cancer therapy such as topotecan and irinotecan are derivatives of the natural alkaloid camptothecin (CPT). The mechanism of CPT poisoning of TOP1 rests on inhibition of the re-ligation function of the enzyme resulting in the stabilization of the TOP1-cleavable complex. In the presence of CPTs this enzyme-DNA complex impairs transcription and DNA replication, resulting in fork stalling and the formation of DNA double-strand breaks (DSB) in proliferating cells. As with most chemotherapeutics, intrinsic and acquired drug resistance represents a hurdle that limits the success of CPT therapy. Preclinical data indicate that resistance to CPT-based drugs might be caused by factors such as (a) poor drug accumulation in the tumor, (b) high rate of drug efflux, (c) mutations in TOP1 leading to failure in CPT docking, or (d) altered signaling triggered by the drug-TOP1-DNA complex, (e) expression of DNA repair proteins, and (f) failure to activate cell death pathways. This review will focus on the issues (d-f). We discuss degradation of TOP1 as part of the repair pathway in the processing of TOP1 associated DNA damage, give a summary of proteins involved in repair of CPT-induced replication mediated DSB, and highlight the role of p53 and inhibitors of apoptosis proteins (IAPs), particularly XIAP and survivin, in cancer cell resistance to CPT-like chemotherapeutics.

  14. Two-moment Bulk Stratiform Cloud Microphysics in the Grid-point Atmospheric Model of IAP LASG (GAMIL)

    Institute of Scientific and Technical Information of China (English)

    SHI Xiangjun; WANG Bin; Xiaohong LIU; Minghuai WANG

    2013-01-01

    A two-moment bulk stratiform microphysics scheme,including recently developed physically-based droplet activation/ice nucleation parameterizations has been implemented into the Grid-point Atmospheric Model of IAP LASG (GAMIL) as an effort to enhance the model's capability to simulate aerosol indirect effects.Unlike the previous one-moment cloud microphysics scheme,the new scheme produces a reasonable representation of cloud particle size and number concentration.This scheme captures the observed spatial variations in cloud droplet number concentrations.Simulated ice crystal number concentrations in cirrus clouds qualitatively agree with in situ observations.The longwave and shortwave cloud forcings are in better agreement with observations.Sensitivity tests show that the column cloud droplet number concentrations calculated from two different droplet activation parameterizations are similar.However,ice crystal number concentration in mixed-phased clouds is sensitive to different heterogeneous ice nucleation formulations.The simulation with high ice crystal number concentration in mixed-phase clouds has less liquid water path and weaker cloud forcing.Furthermore,ice crystal number concentration in cirrus clouds is sensitive to different ice nucleation parameterizations.Sensitivity tests also suggest that the impact of pre-existing ice crystals on homogeneous freezing in old clouds should be taken into account.

  15. The Picture Book of Quantum Mechanics

    CERN Document Server

    Brandt, Siegmund

    2012-01-01

    The aim of this book is to explain the basic concepts and phenomena of quantum mechanics by means of visualization. Computer-generated illustrations in color are used extensively throughout the text, helping to establish the relation between quantum mechanics—wave functions, interference, atomic structure, and so forth—and classical physics—point mechanics, statistical mechanics, and wave optics. Even more important, by studying the pictures in parallel with the text, readers develop an intuition for such notoriously abstract phenomena as • the tunnel effect • excitation and decay of metastable states • wave-packet motion within a well • systems of distinguishable and indistinguishable particles • free wave packets and scattering in 3 dimensions • angular-momentum decomposition • stationary bound states in various 3-dimensional potentials • hybrid states • Kepler motion of wave packets in the Coulomb field • spin and magnetic resonance Illustrations from experiments in a variety of f...

  16. A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis-associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways.

    Science.gov (United States)

    Dagenais, M; Dupaul-Chicoine, J; Champagne, C; Skeldon, A; Morizot, A; Saleh, M

    2016-01-01

    Cellular inhibitors of apoptosis proteins (cIAPs) are critical arbiters of cell death and key mediators of inflammation and innate immunity. cIAP2 is frequently overexpressed in colorectal cancer and in regenerating crypts of ulcerative colitis patients. However, its corresponding functions in intestinal homeostasis and underlying mechanisms in disease pathogenesis are poorly understood. We found that mice deficient in cIAP2 exhibited reduced colitis-associated colorectal cancer tumor burden but, surprisingly, enhanced susceptibility to acute and chronic colitis. The exacerbated colitis phenotype of cIAP2-deficient mice was mediated by increased cell death and impaired activation of the regenerative inflammasome-interleukin-18 (IL-18) pathway required for tissue repair following injury. Accordingly, administration of recombinant IL-18 or pharmacological inhibition of caspases or the kinase RIPK1 protected cIAP2-deficient mice from colitis and restored intestinal epithelial barrier architecture. Thus, cIAP2 orchestrates intestinal homeostasis by exerting a dual function in suppressing cell death and promoting intestinal epithelial cell proliferation and crypt regeneration.

  17. Selected pictures of the month

    CERN Multimedia

    Claudia Marcelloni de Oliveira

    View of a single MDT Big Wheel (on side A in UX15 cavern) taken during its last movement immediately after being assembled and just before being connected to the neighbouring TGC1 wheel. Assembly work on the Cathode Strip Chambers on Small Wheel C in building 190. Connecting the services for the Cathode Strip Chambers. The installation of the optical fibers for the readout of the Cathode Strip Chambers on Small Weel C by the Irvine group. Best from our archives: View of the End Cap Calorimeter and TGC big wheel from the Cryostat side A of ATLAS cavern taken on 22 May 2007. The picture above was taken from the platform in the middle, between the Cryostat and the End-Cap. Muriel hopes you all had a great vacation. She herself had a wonderful time sailing in Galicia (North Western Spain). She can be seen here wearing the traditional dress offered to her by "Los Amigos de las Dornas" (Friends of the Dornas -traditional sailing boats used for fishing) - when she became ...

  18. Vegetarianism and food perception. Selective visual attention to meat pictures.

    Science.gov (United States)

    Stockburger, Jessica; Renner, Britta; Weike, Almut I; Hamm, Alfons O; Schupp, Harald T

    2009-04-01

    Vegetarianism provides a model system to examine the impact of negative affect towards meat, based on ideational reasoning. It was hypothesized that meat stimuli are efficient attention catchers in vegetarians. Event-related brain potential recordings served to index selective attention processes at the level of initial stimulus perception. Consistent with the hypothesis, late positive potentials to meat pictures were enlarged in vegetarians compared to omnivores. This effect was specific for meat pictures and obtained during passive viewing and an explicit attention task condition. These findings demonstrate the attention capture of food stimuli, deriving affective salience from ideational reasoning and symbolic meaning.

  19. Extracting modal parameters of a cable on shaky motion pictures

    Science.gov (United States)

    Hwa Kim, Byeong

    2014-12-01

    A set of modal parameters of a cable are extracted from a motion picture captured by a digital camera operated with shaking hands. It is difficult to identify the center of the targets attached to the cable surface from the blurred motion image of the cable, because of the high-speed motion of the cable, low sampling frequency of the camera, and the effect of shaking hands on the motion pictures. This paper proposes a multi-template matching algorithm to solve these difficulties. In addition, a sensitivity-based system identification algorithm is proposed for extracting the natural frequencies and the damping ratios from ambient cable vibration data. Three sets of vibration tests are performed to examine the validity of the proposed algorithms. The results show that the proposed approach of using these two algorithms is fairly feasible for extracting modal parameters from severely blurred motion pictures.

  20. Retinoic acid protects human breast cancer cells against etoposide-induced apoptosis by NF-kappaB-dependent but cIAP2-independent mechanisms

    Directory of Open Access Journals (Sweden)

    Gronemeyer Hinrich

    2010-01-01

    Full Text Available Abstract Background Retinoids, through their cognate nuclear receptors, exert potent effects on cell growth, differentiation and apoptosis, and have significant promise for cancer therapy and chemoprevention. These ligands can determine the ultimate fate of target cells by stimulating or repressing gene expression directly, or indirectly through crosstalking with other signal transducers. Results Using different breast cancer cell models, we show here that depending on the cellular context retinoids can signal either towards cell death or cell survival. Indeed, retinoids can induce the expression of pro-apoptotic (i.e. TRAIL, TNF-Related Apoptosis-Inducing Ligand, Apo2L/TNFSF10 and anti-apoptotic (i.e. cIAP2, inhibitor of apoptosis protein-2 genes. Promoter mapping, gel retardation and chromatin immunoprecipitation assays revealed that retinoids induce the expression of this gene mainly through crosstalk with NF-kappaB. Supporting this crosstalk, the activation of NF-kappaB by retinoids in T47D cells antagonizes the apoptosis triggered by the chemotherapeutic drugs etoposide, camptothecin or doxorubicin. Notably apoptosis induced by death ligands (i.e. TRAIL or antiFAS is not antagonized by retinoids. That knockdown of cIAP2 expression by small interfering RNA does not alter the inhibition of etoposide-induced apoptosis by retinoids in T47D cells reveals that stimulation of cIAP2 expression is not the cause of their anti-apoptotic action. However, ectopic overexpression of a NF-kappaB repressor increases apoptosis by retinoids moderately and abrogates almost completely the retinoid-dependent inhibition of etoposide-induced apoptosis. Our data exclude cIAP2 and suggest that retinoids target other regulator(s of the NF-kappaB signaling pathway to induce resistance to etoposide on certain breast cancer cells. Conclusions This study shows an important role for the NF-kappaB pathway in retinoic acid signaling and retinoic acid-mediated resistance to

  1. Images of Poverty in Picture Books with International Settings.

    Science.gov (United States)

    Lamme, Linda Leonard

    2000-01-01

    Explores how authors and illustrators of 21 children's picture books with international settings portray children of poverty. Discusses causes and representations of poverty in the books: fathers who leave home to find work; child laborers; modes of transportation; housing; children who lack material goods; and the barter system. Finds…

  2. Holographic motion picture camera with Doppler shift compensation

    Science.gov (United States)

    Kurtz, R. L. (Inventor)

    1976-01-01

    A holographic motion picture camera is reported for producing three dimensional images by employing an elliptical optical system. There is provided in one of the beam paths (the object or reference beam path) a motion compensator which enables the camera to photograph faster moving objects.

  3. Magazine Picture Collage in Group Supervision

    Science.gov (United States)

    Shepard, Blythe C.; Guenette, Francis L.

    2010-01-01

    A magazine picture collage activity was used with three female counsellor education students as a vehicle to support them in processing their experience as counsellors in training. The use of magazine picture collage in group supervision is described, and the benefits and challenges are presented. The collages served as jumping-off points for…

  4. Picture-Word Interference Is Semantically Based

    Science.gov (United States)

    Rosinski, Richard R.

    1977-01-01

    Analysis of the performance of second-, fourth-, sixth-grade, and college-level subjects on picture-word interference tasks indicated that distractor words belonging to the same semantic category as pictures produced more interference than either unrelated words or nonsense trigrams. (Author/JMB)

  5. Wigner method dynamics in the interaction picture

    DEFF Research Database (Denmark)

    Møller, Klaus Braagaard; Dahl, Jens Peder; Henriksen, Niels Engholm

    1994-01-01

    The possibility of introducing an interaction picture in the semiclassical Wigner method is investigated. This is done with an interaction Picture description of the density operator dynamics as starting point. We show that the dynamics of the density operator dynamics as starting point. We show ...... integration of the Schrodinger equation....

  6. An MEG study of picture naming

    NARCIS (Netherlands)

    Levelt, W.J.M.; Praamstra, P.; Meyer, A.S.; Helenius, P.I.; Salmelin, R.

    1998-01-01

    The purpose of this study was to relate a psycholinguistic processing model of picture naming to the dynamics of cortical activation during picture naming. The activation was recorded from eight Dutch subjects with a whole-head neuromagnetometer. The processing model, based on extensive naming

  7. The Untapped Potential of Picture Books

    Science.gov (United States)

    Hager, Stephanie

    2015-01-01

    This article discusses the role picture books play in helping young writers. Third-grade students were read engaging picture books for the sole purpose of noticing and naming different features they encountered during the read-alouds. Students were able to recognize the tools many authors and illustrators use such as onomatopoeia, varied font…

  8. USING PICTURES IN THE LANGUAGE CLASSROOM

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    Visuals are advantageous to language teaching and learning.Effective use of pictures in the lan-guage classroom contributes to stimulate the students’ imagination and creativity,enhance their basic lan-guage skills and heighten their communicative competence.This Paper will present some techniques andactivities with pictures for use in the language class.

  9. The Functions of Pictures in Problem Solving

    Science.gov (United States)

    Elia, Iliada; Philippou, George

    2004-01-01

    In the present study, we assert that pictures serve four functions in problem solving: decorative, representational, organizational and informational. We, therefore, investigate the effects of pictures based on their functions in mathematical problem solving (MPS), by high achievement students of Grade 6 in Cyprus, in a communication setting. A…

  10. Attitudes toward Motion Pictures among College Students.

    Science.gov (United States)

    Austin, Bruce A.

    Several reasons for studying motion pictures and patrons' attitudes toward them include the following: (1) current data show that motion pictures account for 53% of the total United States spectator amusement expenditures; (2) the average weekly United States movie attendance has plummeted by more than half since 1930; (3) despite this decline,…

  11. Systematic In Vivo RNAi Analysis Identifies IAPs as NEDD8-E3 Ligases

    DEFF Research Database (Denmark)

    Broemer, Meike; Tenev, Tencho; Rigbolt, Kristoffer T G;

    2010-01-01

    The intimate relationship between mediators of the ubiquitin (Ub)-signaling system and human diseases has sparked profound interest in how Ub influences cell death and survival. While the consequence of Ub attachment is intensely studied, little is known with regards to the effects of other Ub-li...

  12. Parallel processing for digital picture comparison

    Science.gov (United States)

    Cheng, H. D.; Kou, L. T.

    1987-01-01

    In picture processing an important problem is to identify two digital pictures of the same scene taken under different lighting conditions. This kind of problem can be found in remote sensing, satellite signal processing and the related areas. The identification can be done by transforming the gray levels so that the gray level histograms of the two pictures are closely matched. The transformation problem can be solved by using the packing method. Researchers propose a VLSI architecture consisting of m x n processing elements with extensive parallel and pipelining computation capabilities to speed up the transformation with the time complexity 0(max(m,n)), where m and n are the numbers of the gray levels of the input picture and the reference picture respectively. If using uniprocessor and a dynamic programming algorithm, the time complexity will be 0(m(3)xn). The algorithm partition problem, as an important issue in VLSI design, is discussed. Verification of the proposed architecture is also given.

  13. Rapid induction of false memory for pictures.

    Science.gov (United States)

    Weinstein, Yana; Shanks, David R

    2010-07-01

    Recognition of pictures is typically extremely accurate, and it is thus unclear whether the reconstructive nature of memory can yield substantial false recognition of highly individuated stimuli. A procedure for the rapid induction of false memories for distinctive colour photographs is proposed. Participants studied a set of object pictures followed by a list of words naming those objects, but embedded in the list were names of unseen objects. When subsequently shown full colour pictures of these unseen objects, participants consistently claimed that they had seen them, while discriminating with high accuracy between studied pictures and new pictures whose names did not appear in the misleading word list. These false memories can be reported with high confidence as well as the feeling of recollection. This new procedure allows the investigation of factors that influence false memory reports with ecologically valid stimuli and of the similarities and differences between true and false memories.

  14. Projections of the East Asian Winter Monsoon under the IPCC AR5 Scenarios Using a Coupled Model:IAP_FGOALS

    Institute of Scientific and Technical Information of China (English)

    WEI Ke; BAO Qing

    2012-01-01

    Responses of the East Asian winter monsoon (EAWM) in future projections were studied based on two core future projections of CMIP5 in coordinated experiments with the IAP-coupled model FGOALS2-s.The projected changes of EAWM in climatology,seasonality,and interannual variability are reported here;the projections indicated strong warming in winter season.Warming increased with latitude,ranging from 1℃ to 3℃ in the Representative Concentration Pathways simulation RCP4.5 projection (an experiment that results in additional radiative forcing of ~4.5 W m-2 in 2100) and from 4℃ to 9℃ in the RCP8.5 projection (an experiment that results in additional radiative forcing of ~8.5 W m-2 in 2100).The northerly wind along the East Asian coastal region became stronger in both scenarios,indicating a stronger EAWM.Accordingly,interannual variability (described by the standard deviation of temperature) increased around the South China Sea and lower latitudes and decreased over eastern China,especially in North China.The two EAWM basic modes,defined by the temperature EOF analysis over East Asia,were associated with the Arctic Oscillation (AO) and stratospheric polar vortex.The future projections revealed more total variance attributable to the secondary mode,suggesting additional influences from the stratosphere.The correlation between AO and the leading mode decreased,while the correlation between AO and the secondary mode increased,implying increased complexity regarding the predictability of EAWM interannual variations in future projections.

  15. Development of NATO's recognized environmental picture

    Science.gov (United States)

    Teufert, John F.; Trabelsi, Mourad

    2006-05-01

    An important element for the fielding of a viable, effective NATO Response Force (NRF) is access to meteorological, oceanographic, geospatial data (GEOMETOC) and imagery. Currently, the available GEOMETOC information suffers from being very fragmented. NATO defines the Recognised Environmental Picture as controlled information base for GEOMETOC data. The NATO REP proposes an architecture that is both flexible and open. The focus lies on enabling a network-centric approach. The key into achieving this is relying on using open, well recognized standards that apply to both the data exchange protocols and the data formats. Communication and information exchange based on open standards enables system interoperability. Diverse systems, each with unique, specialized contributions to an increased understanding of the battlespace, can now cooperate to a manageable information sphere. By clearly defining responsibilities in the generation of information, a reduction in data transfer overhead is achieved . REP identifies three main stages in the dissemination of GEOMETOC data. These are Collection, Fusion (and Analysis) and Publication. A REP architecture has been successfully deployed during the NATO Coalition Warrior Interoperability Demonstration (CWID) in Lillehammer, Norway during June 2005. CWID is an annual event to validate and improve the interoperability of NATO and national Consultation and command, control, communications, computers, intelligence, surveillance, and reconnaissance (C4ISR) systems. With a test case success rate of 84%, it was able to provide relevant GEOMETOC support to the main NRF component headquarters. In 2006, the REP architecture will be deployed and validated during the NATO NRF Steadfast live exercises.

  16. An Introduction to Recording, Editing, and Streaming Picture-in-Picture Ultrasound Videos.

    Science.gov (United States)

    Rajasekaran, Sathish; Hall, Mederic M; Finnoff, Jonathan T

    2016-08-01

    This paper describes the process by which high-definition resolution (up to 1920 × 1080 pixels) ultrasound video can be captured in conjunction with high-definition video of the transducer position (picture-in-picture). In addition, we describe how to edit the recorded video feeds to combine both feeds, and to crop, resize, split, stitch, cut, annotate videos, and also change the frame rate, insert pictures, edit the audio feed, and use chroma keying. We also describe how to stream a picture-in-picture ultrasound feed during a videoconference. Copyright © 2016 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.

  17. 多发性骨髓瘤细胞中C-IAP2表达及其相关研究%Expression and research on c-LAP-2 in multiple myeloma cells

    Institute of Scientific and Technical Information of China (English)

    刘善浩; 汪兴洪

    2010-01-01

    目的 探讨细胞凋亡抑制蛋白-2(cellular inhibitor of apoptosis protein-2,C-IAP2)在多发性骨髓瘤(multiple myeloma,MM)发病机制中的作用,为MM治疗提供新的思路和理论依据.方法应用逆转录聚合酶链反应(RT-PCR)检测C-IAP2 mRNA在MM患者中的表达,分析C-IAP2mRNA与半胱氨酸-天门东氨酸酶-3(cysteine-aspartic proteases-3,caspase-3)蛋白、核因子-kBp65(NF-kBp65)mRNA的相互关系.结果初诊MM患者的C-IAP2mRNA表达水平高于对照组(P<0.05),C-IAP2mRNA与NF-kBp65mRNA表达水平呈正相关(r=0.681),与caspase-3蛋白表达水平呈负相关(r=-0.547).结论 C-IAP2mRNA在多发性骨髓瘤中高表达,与对照组相比差异有统计学意义,经分析表明C-IAP2基因在多发性骨髓瘤发病中可能具有促进作用.

  18. Functional magnetic resonance imaging research on bulimia nervosa during executing food pictures%神经性贪食患者食物图片刺激的功能磁共振对照研究

    Institute of Scientific and Technical Information of China (English)

    申远; 李清伟; 王培军; 戴工华; 李春波; 吴文源

    2009-01-01

    目的 观察神经性贪食(BN)患者加工食物图片时的脑功能特点,探讨BN的精神病理机制.方法 BN患者7例,均为女性,符合中国精神障碍分类和诊断标准第三版(CCMD-3)神经性贪食诊断标准;健康对照7例.2组性别、年龄匹配.所有受试者完成汉密尔顿焦虑量表(HAMA)、17项汉密尔顿抑郁量表(HAMD-17)、视觉模拟量表(VAS)评估和fMRI检查.功能成像为组块设计,包括食物图片序列和非食物图片序列,均来自国际情绪图片系统(1APS),计算机自动呈现.结果 BN患者食物图片VAS评分高于对照组(P<0.05);BN患者食物图片平均脑激活强度(7.86±0.78)、平均激活体积(557 voxels),主要激活双侧前额叶、右尾状核、左杏仁核和小脑;对照组食物图片平均脑激活强度(9.89±1.03),平均激活体积均(1340 voxels),主要激活双侧舌回、楔前叶、右梭状回.2组食物图片下激活差异有显著性(P<0.05),非食物图片下激活差异无显著性.结论 前额叶-纹状体-杏仁核-中脑通路功能异常可能是BN的主要神经病理机制.%Objective To observe the brain activation performance of bulimia nervosa (BN) patients and to investigate the possible mental mechanisms of BN. Method Seven female BN cases which met criteria of the 3rd version Chinese Criteria of Mental Diseases (CCMD-3) and seven matched health girls were enrolled. All sub-jects were evaluated by Hamilton anxiety scale (HAMA), Hamilton depression scale (HAMD-17), and visual ana-logue scale (VAS). Then fulfill functional magnetic resonance imaging (fMRI) examination. It was block-design. Food or non-food pictures selected from International Affective Picture System (IAPS) independently composed the food and non-food task run of fMRI and were showed by computer automatically. Result VAS-food score was higher in BN group than in control (P<0.05). The average intensity activated of BN under food pictures was 7.86 ±0.78 ,average volume activated was

  19. Are there sex differences in ERPs related to processing empathy-evoking pictures?

    NARCIS (Netherlands)

    Groen, Y.; Wijers, A. A.; Tucha, O.; Althaus, M.

    Objective: This study aimed to investigate sex differences in the temporal dynamics of experiencing empathy by using electrophysiological measurements. Methods: Twenty-five females and 27 males viewed 414 pictures of the International affective picture system varying in emotional valence (positive,

  20. Defining the core apoptosis pathway in the mosquito disease vector Aedes aegypti: the roles of iap1, ark, dronc, and effector caspases.

    Science.gov (United States)

    Liu, Qingzhen; Clem, Rollie J

    2011-02-01

    To date, our knowledge of apoptosis regulation in insects comes almost exclusively from the model organism Drosophila melanogaster. In contrast, despite the identification of numerous genes that are presumed to regulate apoptosis in other insects based on sequence homology, little has been done to examine the molecular pathways that regulate apoptosis in other insects, including medically important disease vectors. In D. melanogaster, the core apoptosis pathway consists of the caspase negative regulator DIAP1, IAP antagonists, the initiator caspase Dronc and its activating protein Ark, and the effector caspase DrICE. Here we have studied the functions of several genes from the mosquito disease vector Aedes aegypti that share homology with the core apoptosis genes in D. melanogaster. Silencing of the iap1 gene in the A. aegypti cell line Aag2 caused spontaneous apoptosis, indicating that IAP1 plays a role in cell survival similar to that of DIAP1. Silencing A. aegypti ark or dronc completely inhibited apoptosis triggered by several different apoptotic stimuli. However, individual silencing of the effector caspases CASPS7 or CASPS8, which are the closest relatives to DrICE, only partially inhibited apoptosis, and silencing both CASPS7 and CASPS8 together did not have a significant additional effect. Our results suggest that the core pathway that regulates apoptosis in A. aegypti is similar to that of D. melanogaster, but that more than one effector caspase is involved in apoptosis in A. aegypti. This is interesting in light of the fact that the caspase family has expanded in mosquitoes compared to D. melanogaster.

  1. Expression of baculovirus anti-apoptotic genes p35 and op-iap in cotton (Gossypium hirsutum L. enhances tolerance to verticillium wilt.

    Directory of Open Access Journals (Sweden)

    Juan Tian

    Full Text Available BACKGROUND: Programmed cell death plays an important role in mediating plant adaptive responses to the environment such as the invasion of pathogens. Verticillium wilt, caused by the necrotrophic pathogen Verticillium dahliae, is a serious vascular disease responsible for great economic losses to cotton, but the molecular mechanisms of verticillium disease and effective, safe methods of resistance to verticillium wilt remain unexplored. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we introduced baculovirus apoptosis inhibitor genes p35 and op-iap into the genome of cotton via Agrobacterium-mediated transformation and analyzed the response of transgenic plants to verticillium wilt. Results showed that p35 and op-iap constructs were stably integrated into the cotton genome, expressed in the transgenic lines, and inherited through the T(3 generation. The transgenic lines had significantly increased tolerance to verticillium wilt throughout the developmental stages. The disease index of T(1-T(3 generation was lower than 19, significantly (P<0.05 better than the negative control line z99668. After treatment with 250 mg/L VD-toxins for 36 hours, DNA from negative control leaves was fragmented, whereas fragmentation in the transgenic leaf DNA did not occur. The percentage of cell death in transgenic lines increased by 7.11% after 60 mg/L VD-toxin treatment, which was less than that of the negative control lines's 21.27%. This indicates that p35 and op-iap gene expression partially protects cells from VD-toxin induced programmed cell death (PCD. CONCLUSION/SIGNIFICANCE: Verticillium dahliae can trigger plant cells to die through induction of a PCD mechanism involved in pathogenesis. This paper provides a potential strategy for engineering broad-spectrum necrotrophic disease resistance in plants.

  2. Picturing perturbative parton cascades in QCD matter

    Directory of Open Access Journals (Sweden)

    Aleksi Kurkela

    2015-01-01

    Full Text Available Based on parametric reasoning, we provide a simple dynamical picture of how a perturbative parton cascade, in interaction with a QCD medium, fills phase space as a function of time.

  3. Pattern Perception and Pictures for the Blind

    Directory of Open Access Journals (Sweden)

    Melissa McCarthy

    2005-01-01

    Full Text Available This article reviews recent research on perception of tangible pictures in sighted and blind people. Haptic picture naming accuracy is dependent upon familiarity and access to semantic memory, just as in visual recognition. Performance is high when haptic picture recognition tasks do not depend upon semantic memory. Viewpoint matters for the ease or difficulty of interpreting haptic pictures of solid objects. Top views were easiest for sighted and blind persons when geometrical solids had constant crosssections in the vertical axis. The presence or absence of viewpoint effects depends upon the nature of the solids that are represented. Congenitally blind people do not spontaneously produce perspective drawings, but recent data suggests that depictions including linear perspective can be understood after minimal experience. The results suggest that two-dimensional configurations are not necessarily problematic for touch.

  4. Dementia in the movies: The clinical picture

    NARCIS (Netherlands)

    Gerritsen, D.L.; Kuin, Y.; Nijboer, J.

    2014-01-01

    Objectives: Visual media influence the general public's perceptions and attitudes regarding people with mental conditions. This qualitative study investigates the depiction accuracy of dementia's clinical features in motion pictures.Method: Using the search terms 'dementia', 'Alzheimer's disease' an

  5. Dementia in the movies: the clinical picture

    NARCIS (Netherlands)

    Gerritsen, D.; Kuin, Y.; Nijboer, J.

    2014-01-01

    Objectives: Visual media influence the general public's perceptions and attitudes regarding people with mental conditions. This qualitative study investigates the depiction accuracy of dementia's clinical features in motion pictures.Method: Using the search terms dementia', Alzheimer's disease' and

  6. NIH Abroad: Pictures Are Crowd Pullers

    Science.gov (United States)

    ... Pictures Are Crowd Pullers …" Art, culture, and the Internet combine to intervene against malaria in Uganda NLM's ... Services Division collaborated on the project through the Internet. "We wanted to see if such a 'health ...

  7. Lambliasis in Children. Epidemiology, Clinical Picture, Diagnosis

    Directory of Open Access Journals (Sweden)

    A.A. Konyushevskaya

    2014-05-01

    Full Text Available The article considers the lambliasis — one of most common protozoan diseases in children. This article gives a review of literature on epidemiology, clinical picture and diagnosis of lambliasis in children as well as own observations.

  8. Descriptive complexity for pictures languages (extended abstract)

    CERN Document Server

    Grandjean, Etienne; richard, Gaétan

    2012-01-01

    This paper deals with descriptive complexity of picture languages of any dimension by syntactical fragments of existential second-order logic. - We uniformly generalize to any dimension the characterization by Giammarresi et al. \\cite{GRST96} of the class of \\emph{recognizable} picture languages in existential monadic second-order logic. - We state several logical characterizations of the class of picture languages recognized in linear time on nondeterministic cellular automata of any dimension. They are the first machine-independent characterizations of complexity classes of cellular automata. Our characterizations are essentially deduced from normalization results we prove for first-order and existential second-order logics over pictures. They are obtained in a general and uniform framework that allows to extend them to other "regular" structures. Finally, we describe some hierarchy results that show the optimality of our logical characterizations and delineate their limits.

  9. Two Comments on Predictive Picture Coding

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    Two comments on predictive picture coding are given in this paper. 1) In lossy coding, the reconstructed values of picture samples, not its original values, should be used in the prediction formula. 2) In the design of optimum predictors, the minimum entropy or subjective assessment or other criterions, could be used, depending on the applications of the prediction encoder, instead of the minimum mean square error (MMSE) criterion.

  10. La violencia contra niños y niñas: un problema global de abordaje local, mediante la IAP

    Directory of Open Access Journals (Sweden)

    Alejandro Acosta-Ayerbe

    2013-03-01

    Full Text Available En el presente artículo nos ocupamos de las dimensiones y gravedad de la presencia actual de la violencia1 contra la niñez, reflejada en diferentes estudios, informes y recomendaciones de gobiernos y organismos nacionales e internacionales, y de la necesidad de recurrir a opciones de trabajo como la Investigación Acción Participativa, IAP, que permitan abordar la complejidad de los sujetos implicados, por la particularidad que traza la convergencia de factores sociales, culturales, económicos, familiares, personales y jurídicos, en cada contexto.

  11. La violencia contra niños y niñas: un problema global de abordaje local, mediante la IAP

    Directory of Open Access Journals (Sweden)

    Ingrit Gutiérrez-Vega

    2013-01-01

    Full Text Available En el presente artículo nos ocupamos de las dimensiones y gravedad de la presencia actual de la violencia1 contra la niñez, reflejada en diferentes estudios, informes y recomendaciones de gobiernos y organismos nacionales e internacionales, y de la necesidad de recurrir a opciones de trabajo como la Investigación Acción Participativa, IAP, que permitan abordar la complejidad de los sujetos implicados, por la particularidad que traza la convergencia de factores sociales, culturales, económicos, familiares, personales y jurídicos, en cada contexto.

  12. Measuring the reliability of picture story exercises like the TAT.

    Directory of Open Access Journals (Sweden)

    Nicole Gruber

    Full Text Available As frequently reported, psychometric assessments on Picture Story Exercises, especially variations of the Thematic Apperception Test, mostly reveal inadequate scores for internal consistency. We demonstrate that the reason for this apparent shortcoming is not caused by the coding system itself but from the incorrect use of internal consistency coefficients, especially Cronbach's α. This problem could be eliminated by using the category-scores as items instead of the picture-scores. In addition to a theoretical explanation we prove mathematically why the use of category-scores produces an adequate internal consistency estimation and examine our idea empirically with the origin data set of the Thematic Apperception Test by Heckhausen and two additional data sets. We found generally higher values when using the category-scores as items instead of picture-scores. From an empirical and theoretical point of view, the estimated reliability is also superior to each category within a picture as item measuring. When comparing our suggestion with a multifaceted Rasch-model we provide evidence that our procedure better fits the underlying principles of PSE.

  13. Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells.

    Science.gov (United States)

    Shiokawa, Zenyu; Hashimoto, Kentaro; Saito, Bunnai; Oguro, Yuya; Sumi, Hiroyuki; Yabuki, Masato; Yoshimatsu, Mie; Kosugi, Yohei; Debori, Yasuyuki; Morishita, Nao; Dougan, Douglas R; Snell, Gyorgy P; Yoshida, Sei; Ishikawa, Tomoyasu

    2013-12-15

    We previously reported octahydropyrrolo[1,2-a]pyrazine derivative 2 (T-3256336) as a potent antagonist for inhibitors of apoptosis (IAP) proteins. Because compound 2 was susceptible to MDR1 mediated efflux, we developed another scaffold, hexahydropyrazino[1,2-a]indole, using structure-based drug design. The fused benzene ring of this scaffold was aimed at increasing the lipophilicity and decreasing the basicity of the scaffold to improve the membrane permeability across MDR1 expressing cells. We established a chiral pool synthetic route to yield the desired tricyclic chiral isomers. Chemical modification of the core scaffold led to a representative compound 50, which showed strong inhibition of IAP binding (X chromosome-linked IAP [XIAP]: IC50 23 nM and cellular IAP [cIAP]: IC50 1.1 nM) and cell growth inhibition (MDA-MB-231 cells: GI50 2.8 nM) with high permeability and low potential of MDR1 substrate.

  14. Crossmodal interactions during affective picture processing.

    Directory of Open Access Journals (Sweden)

    Vera Ferrari

    Full Text Available "Natural" crossmodal correspondences, such as the spontaneous tendency to associate high pitches with high spatial locations, are often hypothesized to occur preattentively and independently of task instructions (top-down attention. Here, we investigate bottom-up attentional engagement by using emotional scenes that are known to naturally and reflexively engage attentional resources. We presented emotional (pleasant and unpleasant or neutral pictures either below or above a fixation cross, while participants were required to discriminate between a high or a low pitch tone (experiment 1. Results showed that despite a robust crossmodal attentional capture of task-irrelevant emotional pictures, the general advantage in classifying the tones for congruent over incongruent visual-auditory stimuli was similar for emotional and neutral pictures. On the other hand, when picture position was task-relevant (experiment 2, task-irrelevant tones did not interact with pictures with regard to their combination of pitch and visual vertical spatial position, but instead they were effective in minimizing the interference effect of emotional picture processing on the ongoing task. These results provide constraints on our current understanding of natural crossmodal correspondences.

  15. A Story Told by a Picture

    Directory of Open Access Journals (Sweden)

    Yeshayahu Shen

    2010-06-01

    Full Text Available

    Abstract (E: We investigate whether people use a narrative/story schema to organize visual information in figurative isolated pictures representing a "pregnant moment", and, if so, how they do this.  The participants in our study were asked to freely describe pictures that depict some event. Their descriptions were analyzed according to a system of categories developed especially for examining the use of an elaborated narrative organization. The findings support the hypothesis that observers use elaborated narrative organization that goes beyond mere temporal and causal organization (including, e.g., exposition, complication, resolution. Furthermore, the findings suggest that this elaborative narrative organization sometimes dominates the visual organization of the pictures.

     

    Abstract (F: Cet article tente de répondre à la question suivante: est-ce que les spectateurs se servent d’un schéma base sur l

  16. Digital Picture Production and Picture aesthetic Competency in It-didactic Design

    DEFF Research Database (Denmark)

    Rasmussen, Helle

    In my presentation at the InSEA Conference 2015 I want to introduce my ongoing Ph.D. project with the title ‘Digital Picture Production and Picture aesthetic Competency in It-didactic Design’. The objective of the project is to provide a basis for upgrading and renewal of lessons in the school...... subject Visual Arts – and crosswise of subjects in school. The overall research question has been: How can IT-didactic designs support lessons in production of complex meaning in digital pictures and increase the development of pupil’s picture aesthetic competences? By using the expression ‘complex...... potential in digital picture productions will tend to be distinctly complex, such as also Mie Buhl has pointed with reference to Paul Duncum. (Buhl 2005, Duncum 2014). To handle production of such distinctly complex meaning in digital pictures seems to be a didactic challenge in school. It also seems like...

  17. Carl Linnaeus: pictures and propaganda.

    Science.gov (United States)

    Fara, Patricia

    2003-03-01

    How do scientists become famous? Carl Linnaeus was an expert at self-promotion who used portraits to gain patronage and consolidate his reputation. His sexualized classification system was hugely controversial, yet his successors celebrated him as a great hero of botany.

  18. Integration of Pictures and Discourse

    Science.gov (United States)

    1993-01-01

    in retrievability) and an extremely interactive system. Retrieval is based on a resonance metaphor, much like the Minerva II model (Hintzman, 1986...May 1991. Comprension del texto illustrado: los dibujos ayudan a crear modelos mentales. University of Salamanca, July 1991. Building mental models

  19. Developments in Indexing Picture Collections.

    Science.gov (United States)

    Cawkell, A. E.

    1993-01-01

    Discussion of electronic image processing focuses on the need for indexing to ensure adequate retrieval. Highlights include icons, i.e., reduced pictorial surrogates; file staging; indexing languages, including examples of thesauri; and pictorial languages, including a HyperCard system. (Contains eight references.) (LRW)

  20. Quantum-like picture for intrinsic, classical, arrival distributions

    Energy Technology Data Exchange (ETDEWEB)

    Torres-Vega, Gabino [Physics Department, Cinvestav, Apdo. postal 14-740, 07000 Mexico D.F. (Mexico)], E-mail: gabino@fis.cinvestav.mx

    2009-11-20

    We introduce a marginal, quantum-like picture for the arrival of classical quantities in which the representation vectors are the quantities that evolve and probability densities remain static. The representation functions can be seen as probe functions which are the evolution of delta functions with support on a curve in phase space, the time fronts. This procedure provides a classical analog as well as a clear physical interpretation of the 'time eigenstates' used in quantum systems.

  1. Visualizing common operating picture of critical infrastructure

    Science.gov (United States)

    Rummukainen, Lauri; Oksama, Lauri; Timonen, Jussi; Vankka, Jouko

    2014-05-01

    This paper presents a solution for visualizing the common operating picture (COP) of the critical infrastructure (CI). The purpose is to improve the situational awareness (SA) of the strategic-level actor and the source system operator in order to support decision making. The information is obtained through the Situational Awareness of Critical Infrastructure and Networks (SACIN) framework. The system consists of an agent-based solution for gathering, storing, and analyzing the information, and a user interface (UI) is presented in this paper. The UI consists of multiple views visualizing information from the CI in different ways. Different CI actors are categorized in 11 separate sectors, and events are used to present meaningful incidents. Past and current states, together with geographical distribution and logical dependencies, are presented to the user. The current states are visualized as segmented circles to represent event categories. Geographical distribution of assets is displayed with a well-known map tool. Logical dependencies are presented in a simple directed graph, and users also have a timeline to review past events. The objective of the UI is to provide an easily understandable overview of the CI status. Therefore, testing methods, such as a walkthrough, an informal walkthrough, and the Situation Awareness Global Assessment Technique (SAGAT), were used in the evaluation of the UI. Results showed that users were able to obtain an understanding of the current state of CI, and the usability of the UI was rated as good. In particular, the designated display for the CI overview and the timeline were found to be efficient.

  2. Effect of Picture Exchange Communication System on Children with Autism%图片交换沟通系统在儿童孤独症康复护理中的应用

    Institute of Scientific and Technical Information of China (English)

    孔祥颖; 宋福祥; 历虹; 许洪伟; 王亚男; 刘洋

    2014-01-01

    目的:探讨图片交换沟通系统(PECS)在儿童孤独症康复护理中的应用效果。方法孤独症患儿40例随机分为观察组(n=20)和对照组(n=20)。对照组接受常规护理,观察组在常规护理的基础上给予以PECS为指导的康复护理。治疗前、治疗6个月后使用心理教育量表(PEP-3)进行评估。结果两组患儿治疗6个月后,与各自治疗前相比PEP-3评分均有提高(P<0.05);治疗后观察组沟通与行为评分高于对照组(P<0.05)。结论采取PECS指导的康复护理措施能够有效改善孤独症患儿社交功能和语言功能。%Objective To observe the efficacy of Picture Exchange Communication System (PECS) on children with autism applied in rehabilitation nursing care. Methods 40 children with autism were divided randomly into two groups. The control group (n=20) received routine nursing care, and the observation group (n=20) received rehabilitation nursing care based on PECS for 6 months. They were assessed with Psycho-Education Profile (PEP-3) before and after training. Results The scores of PEP-3 improved obviously in all the children (P<0.05) after training, and the score of communication and behaviour improved more in the observation group than in the control group (P<0.05). Conclusion PECS applied in rehabilitation nursing care can improve the sociality and speech for children with autism.

  3. Polyphenols isolated from Allium cepa L. induces apoptosis by suppressing IAP-1 through inhibiting PI3K/Akt signaling pathways in human leukemic cells.

    Science.gov (United States)

    Han, Min Ho; Lee, Won Sup; Jung, Ji Hyun; Jeong, Jae-Hun; Park, Cheol; Kim, Hye Jung; Kim, GonSup; Jung, Jin-Myung; Kwon, Taeg Kyu; Kim, Gi-Young; Ryu, Chung Ho; Shin, Sung Chul; Hong, Soon Chan; Choi, Yung Hyun

    2013-12-01

    Allium cepa Linn is commonly used as supplementary folk remedy for cancer therapy. Evidence suggests that Allium extracts have anti-cancer properties. However, the mechanisms of the anti-cancer activity of A. cepa Linn are not fully elucidated in human cancer cells. In this study, we investigated anti-cancer effects of polyphenols extracted from lyophilized A. cepa Linn (PEAL) in human leukemia cells and their mechanisms. PEAL inhibited cancer cell growth by inducing caspase-dependent apoptosis. The apoptosis was suppressed by caspase 8 and 9 inhibitors. PEAL also up-regulated TNF-related apoptosis-inducing ligand (TRAIL) receptor DR5 and down-regulated survivin and cellular inhibitor of apoptosis 1 (cIAP-1). We confirmed these findings in other leukemic cells (THP-1, K562 cells). In addition, PEAL suppressed Akt activity and the PEAL-induced apoptosis was significantly attenuated in Akt-overexpressing U937 cells. In conclusion, our data suggested that PEAL induced caspase-dependent apoptosis in several human leukemic cells including U937 cells. The apoptosis was triggered through extrinsic pathway by up-regulating DR5 modulating as well as through intrinsic pathway by modulating IAP family members. In addition, PEAL induces caspase-dependent apoptosis at least in part through the inhibition of phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. This study provides evidence that PEAL might be useful for the treatment of leukemia.

  4. Role of the TWEAK-Fn14-cIAP1-NF-kB signaling axis in the regulation of myogenesis and muscle homeostasis

    Directory of Open Access Journals (Sweden)

    Emeka K Enwere

    2014-02-01

    Full Text Available Mammalian skeletal muscle maintains a robust regenerative capacity throughout life, due largely to the presence of a stem cell population known as satellite cells in the muscle milieu. In normal conditions, these cells remain quiescent; they are activated upon injury to become myoblasts, which proliferate extensively and eventually differentiate and fuse to form new multinucleated muscle fibers. Recent findings have identified some of the factors, including the cytokine TNFα-like weak inducer of apoptosis (TWEAK, which govern these cells’ decisions to proliferate, differentiate, or fuse. In this review, we will address the functions of TWEAK, its receptor Fn14, and the associated signal transduction molecule, the cellular inhibitor of apoptosis 1 (cIAP1, in the regulation of myogenesis. TWEAK signaling can activate the canonical NF-κB signaling pathway, which promotes myoblast proliferation and inhibits myogenesis. In addition, TWEAK activates the noncanonical NF-κB pathway, which, in contrast, promotes myogenesis by increasing myoblast fusion. Both pathways are regulated by cIAP1, which is an essential component of downstream signaling mediated by TWEAK and similar cytokines. This review will focus on the seemingly contradictory roles played by TWEAK during muscle regeneration, by highlighting the interplay between the two NF-κB pathways under physiological and pathological conditions. We will also discuss how myogenesis is negatively affected by chronic conditions which affect homeostasis of the skeletal muscle environment.

  5. Danzando la Psicología Social Comunitaria: revisitando la IAP a partir de un curso de danza en una asociación cultural de barrio.

    Directory of Open Access Journals (Sweden)

    Alejandra Astrid León Cedeño

    2010-03-01

    Full Text Available Desde marzo de 2008 he estado apoyando el trabajo artístico-comunitario de una asociación cultural de la periferia de Londrina (Brasil, dándole clases de danza árabe a cinco líderes comunitarias y, recientemente, a otras jóvenes también. El presente texto iba a ser, a principio, un análisis psicosocial de este proceso, pero el mismo ha sido tan rico que inspiró también el movimiento inverso: revisitar las fases de la investigación-acción participativa (IAP, que es la propuesta metodológica usada por en las prácticas psicosociales comunitarias. Tal revisión fue llevada a cabo a partir de las enseñanzas de las alumnas, de la danza y del trabajo del psicólogo social Peter Spink, que se centra en la importancia de la vida cotidiana y reconstruye así lo que puede ser la investigación y la acción de los(las psicólogos sociales. Propongo  hacer una relectura de la IAP a partir de una psicología social libertaria, enraizada en el cuerpo y basada en lo cotidiano, que epistemológicamente se fundamenta en los conocimientos situados (Haraway, 1995.

  6. Evaluation of Surface Air Temperature Change over China and the Globe during the Twentieth Century in IAP AGCM4.0

    Institute of Scientific and Technical Information of China (English)

    DONG Xiao; XUE Feng; ZHANG He; ZENG Qing-Cun

    2012-01-01

    Based on time series and linear trend analysis, the authors evaluated the performance of the fourth gen- eration atmospheric general circulation model developed at the Institute of Atmospheric Physics, Chinese Academy of Sciences (IAP AGCM4.0), in simulating surface air temperature (SAT) during the twentieth century over China and the globe. The numerical experiment is con- ducted by driving the model with the observed sea surface temperature and sea ice. It is shown that IAP AGCM4.0 can simulate the warming trend of the global SAT, with the major wanning regions in the high latitudes of the Northern Hemisphere and the mid-latitudes of the South- ern Hemisphere. While the simulated trend over the whole globe is close to the observation, the model trader- estimates the observed trend over the continents. More- over, the model simulates the spatial distribution of SAT in China, with a bias of approximately -2℃ in eastern China, but with a more serious bias in western China. Compared with the global mean, however, the correlation coefficient between the simulation and observation in China is significantly lower, indicating that there is large uncertainty in simulating regional climate change.

  7. Hierarchical Picture Coding Using Quadtree Decomposition

    Science.gov (United States)

    Buhler, Yves; Fortier, Michel

    1987-10-01

    A new hierarchical encoding scheme for grey-level pictures is presented here. The picture field is split by a modified quadtree algorithm into blocks of size 32 x 32, 16 x 16, 8 x 8 and 4 x 4 pels, according to their subjective importance in the picture. The larger cells, of size 32 x 32, 16 x 16 and 8 x 8 pels, corresponding to uniform or low-detailed areas, are coded at a very low rates by block truncation in the Discrete Cosine Transform field. The smallest blocks, representing mainly high-detailed areas of the like edges or textures are coded with a multi-codebook vector quantization scheme. Due to its structure, such an encoding scheme is especially well adapted for coding "head and shoulders" pictures, mostly encountered in videophone or videoconference application, where large areas of background may appear. Concerning the vector quantization, several techniques were investigated in order to improve the subjective quality and to reduce the search time through the codebooks. This permits a faster elaboration of the codebooks. Results are presented with bit-rates ranging from 0.4 to 0.8 bits/pel depending on the picture complexity.

  8. Effect of Emotional Valence and Time Interval on the False Memory of Pictures among Older Adults%老年人错误记忆的情绪效价和时间效应

    Institute of Scientific and Technical Information of China (English)

    肖红蕊; 龚先旻; 王大华

    2014-01-01

    During the past decades, an increasing amount of studies have focused on the emotional effect of old adults’ memory. However, not a consensus has been reached yet on the effect of emotional valence on false memory in older adulthood. To explain this inconsistency among previous studies, the present study suggested a lack of consideration on both participants' memory quality and response bias. In addition, few studies have ever taken the temporal factor into account;the emotional effect of memory may alter with time. To fill this gap, the present study examined how emotional valence and time interval would influence older adults’ false memory (FM) for emotional pictures within the framework of Signal Detection Theory (SDT). SDT allows for a simultaneous inspection on both discriminability (d′; an index of memory quality) and judgment criteria (β; an index of response bias). Twenty-one elderly participants (aging 67.17 ± 5.03) completed a recognition memory task consisting of one learning phase and two follow-up recognition tests. The learning materials consisted of 180 pictures (60 positive, 60 negative and 60 neutral) selected from the International Affective Pictures System (IAPS). After the learning phase, participants were asked to finish two follow-up recognition tests half an hour later (short time-interval) and three weeks later (long time-interval), respectively. Two different sets of 90 pictures (30 positive, 30 negative and 30 neutral) selected from the IAPS were respectively used as interfering materials in the two recognition tests. It was found that (1) both discriminability (d′) and judgment criteria (β) were negatively correlated with FM (using false alarm rate as its index) in the short time-interval follow-up recognition test, suggesting a joint contribution of these two factors to FM. However, in the long time-interval recognition test, onlyβcould predict older adults’ FM, suggesting that β, rather than d′, took a critical role in

  9. A Framework for Picture Extraction on Search Engine Improved and Meaningful Result

    CERN Document Server

    Sharma, Anamika

    2011-01-01

    Searching is an important tool of information gathering, if information is in the form of picture than it play a major role to take quick action and easy to memorize. This is a human tendency to retain more picture than text. The complexity and the occurrence of variety of query can give variation in result and provide the humans to learn something new or get confused. This paper presents a development of a framework that will focus on recourse identification for the user so that they can get faster access with accurate & concise results on time and analysis of the change that is evident as the scenario changes from text to picture retrieval. This paper also provides a glimpse how to get accurate picture information in advance and extended technologies searching framework. The new challenges and design techniques of picture retrieval systems are also suggested in this paper.

  10. Development of a Rich Picture editor

    DEFF Research Database (Denmark)

    Valente, Andrea; Marchetti, Emanuela

    2010-01-01

    rich picture practice into software proved difficult, therefore, we decided to follow a user-centered approach: design and implement a prototype with basic functionalities, then run a usability test with a few students and professionals. The feedback collected in the test validated our hypothesis circa...... the need of software support for the authoring rich pictures, but also forced us to re-consider the design of our prototype. To gain a deeper understanding of the students' working practice, we also reviewed rich pictures from past student projects. All the information gathered through our study is guiding...... us in the design of the tool next version. At a more general level we realized that modern object-oriented development methodologies, such as agile methods, are informed by design, hence they sometimes assume design skills that programmers do not have or do not value....

  11. Cosmic Inflation from Emergent Spacetime Picture

    CERN Document Server

    Yang, Hyun Seok

    2016-01-01

    We argue that the emergent spacetime picture admits a background-independent formulation of cosmic inflation. The inflation in this picture corresponds to the dynamical emergence of spacetime while the conventional inflation is simply an (exponential) expansion of a preexisting spacetime owing to the vacuum energy carried by an inflaton field. We show that the cosmic inflation arises as a time-dependent solution of the matrix quantum mechanics describing the dynamical process of Planck energy condensate in vacuum without introducing any inflaton field as well as an {\\it ad hoc} inflation potential. Thus the emergent spacetime picture realizes a background-independent description of the inflationary universe which has a sufficiently elegant and explanatory power to defend the integrity of physics against the multiverse hypothesis.

  12. The Role of Pictures in Picture Books on Children's Cognitive Engagement with Mathematics

    Science.gov (United States)

    Elia, Iliada; van den Heuvel-Panhuizen, Marja; Georgiou, Alexia

    2010-01-01

    The present study examines the cognitive activity that is evoked in young children when they are read a picture book that is written for the purpose of teaching mathematics. The focus of this study is to explore the effects of pictures on children's spontaneous mathematical cognitive engagement. The study is based on the assumption that the…

  13. Picture or Text First? Explaining Sequence Effects When Learning with Pictures and Text

    Science.gov (United States)

    Eitel, Alexander; Scheiter, Katharina

    2015-01-01

    The present article reviews 42 studies investigating the role of sequencing of text and pictures for learning outcomes. Whereas several of the reviewed studies revealed better learning outcomes from presenting the picture before the text rather than after it, other studies demonstrated the opposite effect. Against the backdrop of theories on…

  14. The Role of Pictures in Picture Books on Children's Cognitive Engagement with Mathematics

    Science.gov (United States)

    Elia, Iliada; van den Heuvel-Panhuizen, Marja; Georgiou, Alexia

    2010-01-01

    The present study examines the cognitive activity that is evoked in young children when they are read a picture book that is written for the purpose of teaching mathematics. The focus of this study is to explore the effects of pictures on children's spontaneous mathematical cognitive engagement. The study is based on the assumption that the…

  15. Spatial Vegetation Data for Pictured Rocks National Lakeshore Vegetation Mapping Project

    Data.gov (United States)

    National Park Service, Department of the Interior — The geographic information system (GIS) format spatial data set of vegetation for Pictured Rocks National Lakeshore (PIRO) was created by the National Park Service...

  16. The early atmosphere: a new picture.

    Science.gov (United States)

    Levine, J S

    1986-01-01

    Over the last several years, many of the fundamental ideas concerning the composition and chemical evolution of the Earth's early atmosphere have changed. While many aspects of this subject are clouded--either uncertain or unknown, a new picture is emerging. We are just beginning to understand how astronomical, geochemical, and atmospheric processes each contributed to the development of the gaseous envelope around the third planet from the sun some 4.6 billion years ago and how that envelope chemically evolved over the history of our planet. Simple compounds in that gaseous envelope, energized by atmospheric lightning and/or solar ultraviolet radiation, formed molecules of increasing complexity that eventually evolved into the first living systems on our planet. This process is called "chemical evolution" and immediately preceded biological evolution; once life developed and evolved, it began to alter the chemical composition of the atmosphere that provided the very essence of its creation. Photosynthetic organisms which have the ability to biochemically transform carbon dioxide and water to carbohydrates, which they use for food, produce large amounts of molecular oxygen (O2) as a by-product of the reaction. Atmospheric oxygen photochemically formed ozone, which absorbs ultraviolet radiation from the sun and shields the Earth's surface from this biologically lethal radiation. Once atmospheric ozone levels increased sufficiently, life could leave the safety of the oceans and go ashore for the first time. Throughout the history of our planet, there has been strong interaction between life and the atmosphere. Understanding our cosmic roots is particularly relevant as we embark on a search for life outside the Earth. At this very moment, several radio telescopes around the world are searching for extraterrestrial intelligence (SETI).

  17. Communicating pictures a course in image and video coding

    CERN Document Server

    Bull, David R

    2014-01-01

    Communicating Pictures starts with a unique historical perspective of the role of images in communications and then builds on this to explain the applications and requirements of a modern video coding system. It draws on the author's extensive academic and professional experience of signal processing and video coding to deliver a text that is algorithmically rigorous, yet accessible, relevant to modern standards, and practical. It offers a thorough grounding in visual perception, and demonstrates how modern image and video compression methods can be designed in order to meet the rate-quality performance levels demanded by today's applications, networks and users. With this book you will learn: Practical issues when implementing a codec, such as picture boundary extension and complexity reduction, with particular emphasis on efficient algorithms for transforms, motion estimators and error resilience Conflicts between conventional video compression, based on variable length coding and spatiotemporal prediction,...

  18. Neural correlates of processing negative and sexually arousing pictures.

    Directory of Open Access Journals (Sweden)

    Kira Bailey

    Full Text Available Recent work has questioned whether the negativity bias is a distinct component of affective picture processing. The current study was designed to determine whether there are different neural correlates of processing positive and negative pictures using event-related brain potentials. The early posterior negativity and late positive potential were greatest in amplitude for erotic pictures. Partial Least Squares analysis revealed one latent variable that distinguished erotic pictures from neutral and positive pictures and another that differentiated negative pictures from neutral and positive pictures. The effects of orienting task on the neural correlates of processing negative and erotic pictures indicate that affective picture processing is sensitive to both stimulus-driven, and attentional or decision processes. The current data, together with other recent findings from our laboratory, lead to the suggestion that there are distinct neural correlates of processing negative and positive stimuli during affective picture processing.

  19. Neural Correlates of Processing Negative and Sexually Arousing Pictures

    Science.gov (United States)

    Bailey, Kira; West, Robert; Mullaney, Kellie M.

    2012-01-01

    Recent work has questioned whether the negativity bias is a distinct component of affective picture processing. The current study was designed to determine whether there are different neural correlates of processing positive and negative pictures using event-related brain potentials. The early posterior negativity and late positive potential were greatest in amplitude for erotic pictures. Partial Least Squares analysis revealed one latent variable that distinguished erotic pictures from neutral and positive pictures and another that differentiated negative pictures from neutral and positive pictures. The effects of orienting task on the neural correlates of processing negative and erotic pictures indicate that affective picture processing is sensitive to both stimulus-driven, and attentional or decision processes. The current data, together with other recent findings from our laboratory, lead to the suggestion that there are distinct neural correlates of processing negative and positive stimuli during affective picture processing. PMID:23029071

  20. The Work of the Motion Picture Cameraman.

    Science.gov (United States)

    Young, Freddie; Petzold, Paul

    Meant to serve as an authoritative source of information on camera work in large scale feature productions, this book attempts to give some basic understanding of the problems of motion picture photography, the working conditions and artistry of lighting for mood and dramatic effect, budget problems for making films, and facts about working with a…

  1. The Last Great American Picture Show

    NARCIS (Netherlands)

    Elsaesser, Thomas; King, Noel; Horwath, Alexander

    2004-01-01

    The Last Great American Picture Show brings together essays by scholars and writers who chart the changing evaluations of the American cinema of the 1970s, sometimes referred to as the decade of the lost generation, but now more and more recognized as the first New Hollywood, without which the cinem

  2. Learning about Environmental Print through Picture Books.

    Science.gov (United States)

    Kuby, Patricia; And Others

    1996-01-01

    Describes picture books that contain environmental print (print found in the natural environment of a child, such as logos, billboards, and road signs) and how they can be used in the classroom. Includes "ABC Drive!" by Naomi Howland (1994), "The Signmaker's Assistant" by Tedd Arnold (1992), and four others. Also provides a…

  3. Bilingual Picture Books: Libros Para Todos.

    Science.gov (United States)

    Agosto, Denise

    1997-01-01

    Discusses the importance of including bilingual English/Spanish picture books in library collections, introduces some recent titles, and describes some programming ideas. Topics include second language study, children teaching English to Spanish-speaking parents, cultural studies, and bilingual presentations. (LRW)

  4. Perseverant Responding in Children's Picture Naming

    Science.gov (United States)

    Booth, Josephine; Vitkovitch, Melanie

    2008-01-01

    Two groups of children were given pictures of animals to name as quickly as they could. The groups comprised 40 nursery aged children (mean age 3 ; 11) and 40 Year 2 children (mean age 6 ; 9) attending primary school in London. The 30 animals were presented one by one, on cards, and any errors made by the children were noted. Consistent with a…

  5. Bilingual Picture Books: Libros Para Todos.

    Science.gov (United States)

    Agosto, Denise

    1997-01-01

    Discusses the importance of including bilingual English/Spanish picture books in library collections, introduces some recent titles, and describes some programming ideas. Topics include second language study, children teaching English to Spanish-speaking parents, cultural studies, and bilingual presentations. (LRW)

  6. Princess Picture Books: Content and Messages

    Science.gov (United States)

    Dale, Lourdes P.; Higgins, Brittany E.; Pinkerton, Nick; Couto, Michelle; Mansolillo, Victoria; Weisinger, Nica; Flores, Marci

    2016-01-01

    Because many girls develop their understanding of what it means to be a girl from books about princesses, the researchers coded the messages and content in 58 princess books (picture, fairy tales, and fractured fairy tales). Results indicate that gender stereotypes are present in the books--the princesses were more likely to be nurturing, in…

  7. Young Children, National Tragedy, and Picture Books.

    Science.gov (United States)

    McMath, Joan S.

    1997-01-01

    Suggests that, rather than exposing young children to media coverage of national tragedies and disasters, caregivers should read aloud to children from picture books that convey stability, calmness, and reassurance. Includes tips for helping children cope with tragedy, guidelines for selecting books, and an annotated list of 25 books that can help…

  8. Motion Picture and Videotape Analysis of Behavior.

    Science.gov (United States)

    Carpenter, Geoffrey C.; Duvall, David

    1983-01-01

    Use of motion pictures and videotape recordings to analyze animal behavior is described. Indicates that accuracy/amount of data available is greatly increased and that simultaneous behaviors of different animals can be studied or individual behavior patterns increased/decreased, providing observers with temporal perceptions similar to the animals…

  9. Learning about Environmental Print through Picture Books.

    Science.gov (United States)

    Kuby, Patricia; And Others

    1996-01-01

    Describes picture books that contain environmental print (print found in the natural environment of a child, such as logos, billboards, and road signs) and how they can be used in the classroom. Includes "ABC Drive!" by Naomi Howland (1994), "The Signmaker's Assistant" by Tedd Arnold (1992), and four others. Also provides a bibliography of other…

  10. Do Natural Pictures Mean Natural Tastes?

    DEFF Research Database (Denmark)

    Smith, Viktor; Barratt, Daniel; Sørensen, Henrik Selsøe

    2015-01-01

    A widespread assumption in Danish consumer law is that if the package of a food product carries a picture of a potentially taste-giving ingredient (say, a strawberry), then consumers will expect the corresponding taste to stem primarily from that ingredient rather than from artificial flavouring...

  11. Abnormal activation of the occipital lobes during emotion picture processing in major depressive disorder patients

    Institute of Scientific and Technical Information of China (English)

    Jianying Li; Cheng Xu; Xiaohua Cao; Qiang Gao; Yan Wang; Yanfang Wang; Juyi Peng; Kerang Zhang

    2013-01-01

    A large number of studies have demonstrated that depression patients have cognitive dysfunction. With recently developed brain functional imaging, studies have focused on changes in brain function to investigate cognitive changes. However, there is still controversy regarding abnormalities in brain functions or correlation between cognitive impairment and brain function changes. Thus, it is important to design an emotion-related task for research into brain function changes. We selected positive, neutral, and negative pictures from the International Affective Picture System. Patients with major depressive disorder were asked to judge emotion pictures. In addition, functional MRI was performed to synchronously record behavior data and imaging data. Results showed that the total correct rate for recognizing pictures was lower in patients compared with normal controls. Moreover, the consistency for recognizing pictures for depressed patients was worse than normal controls, and they frequently recognized positive pictures as negative pictures. The consistency for recognizing pictures was negatively correlated with the Hamilton Depression Rating Scale. Functional MRI suggested that the activation of some areas in the frontal lobe, temporal lobe, parietal lobe, limbic lobe, and cerebellum was enhanced, but that the activation of some areas in the frontal lobe, parietal lobe and occipital lobe was weakened while the patients were watching positive and neutral pictures compared with normal controls. The activation of some areas in the frontal lobe, temporal lobe, parietal lobe, and limbic lobe was enhanced, but the activation of some areas in the occipital lobe were weakened while the patients were watching the negative pictures compared with normal controls. These findings indicate that patients with major depressive disorder have negative cognitive disorder and extensive brain dysfunction. Thus, reduced activation of the occipital lobe may be an initiating factor for

  12. Abnormal activation of the occipital lobes during emotion picture processing in major depressive disorder patients.

    Science.gov (United States)

    Li, Jianying; Xu, Cheng; Cao, Xiaohua; Gao, Qiang; Wang, Yan; Wang, Yanfang; Peng, Juyi; Zhang, Kerang

    2013-06-25

    A large number of studies have demonstrated that depression patients have cognitive dysfunction. With recently developed brain functional imaging, studies have focused on changes in brain function to investigate cognitive changes. However, there is still controversy regarding abnormalities in brain functions or correlation between cognitive impairment and brain function changes. Thus, it is important to design an emotion-related task for research into brain function changes. We selected positive, neutral, and negative pictures from the International Affective Picture System. Patients with major depressive disorder were asked to judge emotion pictures. In addition, functional MRI was performed to synchronously record behavior data and imaging data. Results showed that the total correct rate for recognizing pictures was lower in patients compared with normal controls. Moreover, the consistency for recognizing pictures for depressed patients was worse than normal controls, and they frequently recognized positive pictures as negative pictures. The consistency for recognizing pictures was negatively correlated with the Hamilton Depression Rating Scale. Functional MRI suggested that the activation of some areas in the frontal lobe, temporal lobe, parietal lobe, limbic lobe, and cerebellum was enhanced, but that the activation of some areas in the frontal lobe, parietal lobe and occipital lobe was weakened while the patients were watching positive and neutral pictures compared with normal controls. The activation of some areas in the frontal lobe, temporal lobe, parietal lobe, and limbic lobe was enhanced, but the activation of some areas in the occipital lobe were weakened while the patients were watching the negative pictures compared with normal controls. These findings indicate that patients with major depressive disorder have negative cognitive disorder and extensive brain dysfunction. Thus, reduced activation of the occipital lobe may be an initiating factor for

  13. Adiabatic Floquet Picture for Hydrogen Atom in an Intense Laser Field

    CERN Document Server

    Wang, Yujun; Esry, B D

    2010-01-01

    We develop an adiabatic Floquet picture in the length gauge to describe the dynamics of a hydrogen atom in an intense laser field. In this picture, we discuss the roles played by frequency and intensity in terms of adiabatic potentials and the couplings between them, which gives a physical and intuitive picture for quantum systems exposed to a laser field. For simplicity, analyze hydrogen and give the adiabatic potential curves as well as some physical quantities that can be readily calculated for the ground state. Both linearly and circularly polarized laser fields are discussed.

  14. Capacitación turística en comunidades indígenas. Un caso de Investigación Acción Participativa (IAP

    Directory of Open Access Journals (Sweden)

    Mariajosé Pastor-Alfonso

    2015-01-01

    Full Text Available La literatura académica subraya la importancia de involucrar a la comunidad en los procesos de capacitación turística. Sin embargo, apenas hay reflexiones sobre cómo diseñar e implementar la formación en áreas rurales y remotas. En este trabajo se exponen las cuatro fases de un ciclo de Investigación Acción Participativa (IAP, desarrollada en la Selva Lacandona de México con la colaboración de los grupos originarios lacandones y ch’oles. El objetivo de estudio fue la capacitación humana en las áreas de sistemas turísticos, interpretación del patrimonio natural y cultural, y creación de producto. Todo ello complementado con una capacitación específica para mujeres y jóvenes, grupos tradicionalmente relegados en estas comunidades. El relato de las distintas fases de la IAP nos muestra cómo el conocimiento ancestral es la base para una capacitación turística sólida. La involucración de jóvenes estudiantes en los procesos de formación en comunidades, los formatos adaptados a los contextos locales, y los ejercicios de reciprocidad científica, sirven además para la revitalización cultural, el refuerzo de la autoestima y el desarrollo endógeno de los pueblos indígenas.

  15. 基于IAP15F2K61S2单片机的多功能小车设计

    Institute of Scientific and Technical Information of China (English)

    邓非; 尹洪东

    2015-01-01

    随着微电子科研技术的日益发展与进步,仿真智能小车已经具备了很高的研究与开发潜力.本次设计的主要目标为:设计出以IAP15F2K61S2单片机芯片为控制核心的具备红外周波遥控、光电测速、液晶实时显示以及电量检测报警功能的智能小车.其中,TCRT5000光电测速器采用测量码盘透光数的方法,实现了小车的测速功能.经过反复修改调试后,小车在实现了预期功能的基础上,具备了很高的稳定性、灵敏性及可靠性.%With the increasingly progress of microelectronics technology and mature,Simulation of smart car has a high re-search and development potential. The design of the main target is:Designed to IAP15F2K61S2 single-chip microcomputer as the control core with infrared frequency of remote control, photoelectric tachometer, liquid crystal display and real-time power detection alarm function of the intelligent vehicle. Among them, the TCRT5000 photoelectric velometer by adopting the method of measuring the number of encoder pervious to light, achieve the function of the car speed. After revising the debugging, the car on the basis of realize the expected function, has the high stability, sensitivity and reliability.

  16. Get the picture? The effects of iconicity on toddlers' reenactment from picture books.

    Science.gov (United States)

    Simcock, Gabrielle; DeLoache, Judy

    2006-11-01

    What do toddlers learn from everyday picture-book reading interactions? To date, there has been scant research exploring this question. In this study, the authors adapted a standard imitation procedure to examine 18- to 30-month-olds' ability to learn how to reenact a novel action sequence from a picture book. The results provide evidence that toddlers can imitate specific target actions on novel real-world objects on the basis of a picture-book interaction. Children's imitative performance after the reading interaction varied both as a function of age and the level of iconicity of the pictures in the book. These findings are discussed in terms of children's emerging symbolic capacity and the flexibility of the cognitive representation.

  17. NATIONAL WORLD PICTURE THROUGH THE PRISM OF SOCIO-POLITICAL DISCOURSE

    Directory of Open Access Journals (Sweden)

    Kurganova, N.I.

    2016-06-01

    Full Text Available The article dwells on the methodological basis of studying the world picture specificity through the prism of social-political discourse. World picture as a system of knowledge, ideas, value judgments developed by all the members of a linguacultural community and represented in words and texts, reflects the results of a cognitive activity that permits to study it as a structured and systemic phenomenon. The authors propose a set of methods and procedures of modelling the parameters of world picture with special reference to the seasonal data collection from the Canadian newspaper Le Devoir (issued in French in the Province of Quebec, such as: distinguishing key concepts, modelling a cognitive, field, and semantic structure of concepts as elements of the world picture.

  18. MIP- MULTIMISSION INTERACTIVE PICTURE PLANNING PROGRAM

    Science.gov (United States)

    Callahan, J. D.

    1994-01-01

    The Multimission Interactive Picture Planner, MIP, is a scientifically accurate and fast, 3D animation program for deep space. MIP is also versatile, reasonably comprehensive, portable, and will run on microcomputers. New techniques were developed to rapidly perform the calculations and transformations necessary to animate scientifically accurate 3D space. At the same time, portability is maintained, as the transformations and clipping have been written in FORTRAN 77 code. MIP was primarily designed to handle Voyager, Galileo, and the Space Telescope. It can, however, be adapted to handle other missions. The space simulation consists of a rotating body (usually a planet), any natural satellites, a spacecraft, the sun, stars, descriptive labelling, and field of view boxes. The central body and natural satellites are tri-axial wireframe representations with terminators, limbs, and landmarks. Hidden lines are removed for the central body and natural satellites, but not for the scene as a whole so that bodies may be seen behind one another. The program has considerable flexibility in its step time, observer position, viewed object, field of view, etc. Most parameters may be changed from the keyboard while the simulation is running. When MIP is executed it will ask the user for a control file, which should be prepared before execution. The control file identifies which mission MIP should simulate, the star catalog files, the ephemerides files to be used, the central body, planets, asteroids, and comets, and solar system landmarks and constants such as planets, asteroids, and comets. The control file also describes the fields of view. Control files are included to simulate the Voyager 1 encounter at Jupiter and the Giotto spacecraft's flyby of Halley's comet. Data is included for Voyager 1 and 2 (all 6 planetary encounters) and Giotto. MIP was written for an IBM PC or compatibles. It requires 512K of RAM, a CGA or compatible graphics adapter, and DOS 2.0 or higher. Users

  19. Reprint of "Affective picture processing as a function of preceding picture valence: an ERP analysis".

    Science.gov (United States)

    Schupp, Harald T; Schmälzle, Ralf; Flaisch, Tobias; Weike, Almut I; Hamm, Alfons O

    2013-03-01

    Event-related brain potential (ERP) studies consistently revealed that a relatively early (early posterior negativity; EPN) and a late (late positive potential; LPP) ERP component differentiate between emotional and neutral picture stimuli. Two studies examined the processing of emotional stimuli when preceded either by pleasant, neutral, or unpleasant context images. In both studies, distinct streams of six pictures were shown. In Study 1, hedonic context was alternated randomly across the 180 picture streams. In Study 2, hedonic context sequences were blocked, resulting in 60 preceding sequences of pleasant, neutral, and unpleasant context valence, respectively. The main finding was that the valence of the preceding picture sequence had no significant effect on the emotional modulation of the EPN and LPP components. However, previous results were replicated in that emotional stimulus processing was associated with larger EPN and LPP components as compared to neutral pictures. These findings suggest that the prioritized processing of emotional stimuli is primarily driven by the valence of the current picture. Copyright © 2013 Elsevier B.V. All rights reserved.

  20. The Complex Picture Test in Dementia

    Directory of Open Access Journals (Sweden)

    K. Gustaw Rothenberg

    2012-10-01

    Full Text Available The newly developed Complex Picture Test (CPT examines main cognitive domains, especially perceptual and visual-spatial abilities. The potential usefulness of the CPT in the assessment of dementia was evaluated. Patients with different forms of dementia [14 vascular dementia (VaD, 30 Alzheimer’s disease (AD, 6 Parkinson’s disease dementia (PDD], 12 subjects with mild cognitive impairment (MCI, and 30 matched controls were examined by the CPT, Mini-Mental State Examination (MMSE, the WAIS-R Digit Span subtest, and the Clock Drawing Test (CDT. The CPT consists of 10 complex pictures, each presenting characteristics paradoxically in opposition to each other. The subjects scored points for naming the object and noticing the paradox. One point was added for commenting on the paradox without prompting (3 points each picture/maximum of 30. CPT scores were significantly higher in the control group (mean ± SD, 29.46 ± 1.43 than in the AD, VaD, MCI, and PDD groups (13.1 ± 2.3, 16.9 ± 3.5, 23.2 ± 1.4, and 23.6 ± 3.4, respectively; p < 0.05. Significant positive correlations between MMSE, Digit Span, CDT, and CPT scores were observed (rho 0.76, 0.35, and 0.56, respectively. These data show perception of complex pictures being compromised in dementia. The correlation between CPT scores and MMSE scores suggests that tests may be used as a brief screening tool for dementia.

  1. Aestheticism in the Picture of Dorian Gray

    Institute of Scientific and Technical Information of China (English)

    康妮芝

    2009-01-01

    Aestheticism or aestheticism movement Was an impomuat phenomenon during the hter nineteenth century.Aestheticism advocated the phrase"art for art's sake".Oscar Wildewas the most famous aestheticism writer during the later nineteenth century in Enghnd.His novel the Picture of Dorian Gray was the representative show of his aestheticism thought.The passage mainly shows Wilde's aestheticism thought of the novel in three aspects.

  2. Phenomenology on the QCD dipole picture revisited

    CERN Document Server

    Lengyel, A I

    2003-01-01

    We perform an adjust to the most recent structure function data, considering the QCD dipole picture applied to ep scattering. The structure function F2 at small x and intermediate Q2 can be described by the model containing an economical number of free-parameters, which encodes the hard Pomeron physics. The longitudinal structure function and the gluon distribution are predicted without further adjustments. The data description is effective, whereas a resummed next-to-leading level analysis is deserved.

  3. The ideal subject distance for passport pictures.

    Science.gov (United States)

    Verhoff, Marcel A; Witzel, Carsten; Kreutz, Kerstin; Ramsthaler, Frank

    2008-07-04

    In an age of global combat against terrorism, the recognition and identification of people on document images is of increasing significance. Experiments and calculations have shown that the camera-to-subject distance - not the focal length of the lens - can have a significant effect on facial proportions. Modern passport pictures should be able to function as a reference image for automatic and manual picture comparisons. This requires a defined subject distance. It is completely unclear which subject distance, in the taking of passport photographs, is ideal for the recognition of the actual person. We show here that the camera-to-subject distance that is perceived as ideal is dependent on the face being photographed, even if the distance of 2m was most frequently preferred. So far the problem of the ideal camera-to-subject distance for faces has only been approached through technical calculations. We have, for the first time, answered this question experimentally with a double-blind experiment. Even if there is apparently no ideal camera-to-subject distance valid for every face, 2m can be proposed as ideal for the taking of passport pictures. The first step would actually be the determination of a camera-to-subject distance for the taking of passport pictures within the standards. From an anthropological point of view it would be interesting to find out which facial features allow the preference of a shorter camera-to-subject distance and which allow the preference of a longer camera-to-subject distance.

  4. A motion picture presentation of magnetic pulsations

    Science.gov (United States)

    Suzuki, A.; Kim, J. S.; Sugura, M.; Nagano, H.

    1981-01-01

    Using the data obtained from the IMS North American magnetometer network stations at high latitudes, a motion picture was made by a computer technique, describing time changes of Pc5 and Pi3 magnetic pulsation vectors. Examples of pulsation characteristics derived from this presentation are regional polarization changes including shifts of polarization demarcation lines, changes in the extent of an active region and its movement with time.

  5. A Spectrum is Worth a Thousand Pictures

    Science.gov (United States)

    Gelderman, Richard F.

    2006-12-01

    A wise astronomer once pointed out that if a picture is worth a thousand words, then a spectrum is worth a thousand pictures. Unfortunately, spectra are rarely emphasized in the introductory astronomy courses and few students exit such a course with any meaningful understanding or appreciation of spectroscopy. Part of the problem is lack of background knowledge; the typical introductory astronomy student has little experience with spectroscopy or atomic physics. Another issue is that spectra are not pretty pictures and are not intuitively understandable. We present and discuss a series of “minds-on” exercises and activities built into a college-level “stars, galaxies, and cosmology” intro astronomy course. The lessons are structured to help students improve their ability to recognize patterns and improve their ability to really see the details in front of them. Another goal is for students to realize there is “more than meets the eye” to learn how to discover “hidden” diagnostics, such as different sources of light their eyes see as white light. A curriculum that emphasizes spectroscopy also provides the opportunity to stress the story of the “Harvard Women,” a tale that bridges gender gaps and often humanizes scientists in the eyes of non-science majors. Finally, with a solid foundation in spectroscopy, students are better prepared to understand exciting topics such as Hubble’s Law and the importance of primordial nucleosynthesis.

  6. Cut and paste pictures in surrealism

    Directory of Open Access Journals (Sweden)

    Todić Milanka

    2006-01-01

    Full Text Available Proceeding from the idea of the readymade, Marko Ristić’s, Vane Bor’s and Dušan Matić’s collages regroup readymade pictorial and textual matrices according to the rules of free associative syntax. Everything that they collected cut out and pasted bears the hallmark of personal choice, i.e. objective chance, as the Surrealists would say. In the new structure of the collage, picture and text were of equal importance. However, we should not forget that both picture and text were only fragments, of different origin so that they could not function as autonomous elements in their own right nor could they establish logical interlinks. Cut and paste picture in Surrealism are primarily registered as visual wholes, in which the former principle of harmony has been substituted by the principle of discontinuity. In fact, they do not aspire to establish closed and unambiguous semantic structures either on a single paper or within a cycle, disregarding as they do conventional narrative and illustrative order in representing reality.

  7. PEOPLE RETRIEVAL BY MEANS OF COMPOSITE PICTURES: PROBLEM STATE-OF-THE-ART AND TECHNOLOGIES

    Directory of Open Access Journals (Sweden)

    Georgy A. Kukharev

    2014-11-01

    Full Text Available We discuss the problem of people retrieval by means of composite pictures constructed according to descriptive portrait. An overview of the problem state-of-the-art is provided beginning from the basic concepts and terminology to a modern technology for composite picture creation, real-world scenarios and search results. The development history of systems for forming composite portraits (photo robots and sketches and the ideas implemented in these systems are provided. The problem of automatic comparison of composite pictures with the original ones is discussed, and the reasons for unattainability of stable retrieval of originals by a composite picture in real-world scenarios are revealed. Requirements to composite pictures databases in addition to the existing benchmark databases of facial images and also methods for implementation of such databases are formulated. Approaches for generation of sketches population from an initial one that increase effectiveness of identikit-based photo image retrieval systems are proposed. The method of similarity index increasing in the couple identikit-photograph based on computation of an average identikit from the created population is provided. It is shown that such composite pictures are more similar to original portraits and their use in the discussed search problem can lead to good results. Thus the created identikits meet the requirements of the truthful scenario as take into account the possibility of incomplete information in descriptions. Results of experiments on CUHK Face Sketch and CUHK Face Sketch FERET databases and also open access identikits and corresponding photos are discussed.

  8. 基于量子力学的相互作用绘景构造非线性哈密顿系统的数值计算方法%Construction of Numerical Methods of Nonlinear Hamiltonian Systems Based on Interaction Picture of Quantum Mechanics

    Institute of Scientific and Technical Information of China (English)

    张素英

    2012-01-01

    Numerical methods of nonlinear Hamiltonian systems are constructed in the interaction picture of quantum mechanics. Firstly the original system is transformed to interaction picture of quantum mechanics. This reduces the problem to a system of ordinary differential equations in time. Subsequently,the modified system is integrated in time and then transformed back to the initial representation of the state vector. Varies discrete schemes can be obtained based on different integration methods. The methods in this paper can also be used to solve multi-component Bose-Einstein condensate problem.%文章在量子力学的相互作用绘景中给出了非线性哈密顿系统离散格式的构造方法.首先将原非线性哈密顿问题变换至相互作用绘景,导出一个含时的常微分方程系统,离散该常微分方程并变换回原系统的态矢即可得到原问题的离散格式.基于不同的常微分方程数值方法,可得到原系统不同的离散格式.该方法还可以有效地求解多组分的Bose-Einstein凝聚态物理问题.

  9. Health Information Technologies for Geriatrics: The Big Picture.

    Science.gov (United States)

    Crawford, Vallaurie; Syed-Abdul, Shabbir

    2016-01-01

    Nearly five decades ago in 1970, Simone de Beauvoir's "The Coming of Age" painted a broad-strokes picture of urgent issues affecting the welfare of elders in many cultures. Using her agenda and others, this panel will attempt to sketch what specific technological advances and applications offer to older citizens, clients and patients - over these 50 years and into the future. Rapid aging societies warrants the need to transform health systems to be focused on preventions and patient engagement rather than the curative care.

  10. Quasi-Linear Algebras and Integrability (the Heisenberg Picture

    Directory of Open Access Journals (Sweden)

    Alexei Zhedanov

    2008-02-01

    Full Text Available We study Poisson and operator algebras with the ''quasi-linear property'' from the Heisenberg picture point of view. This means that there exists a set of one-parameter groups yielding an explicit expression of dynamical variables (operators as functions of ''time'' t. We show that many algebras with nonlinear commutation relations such as the Askey-Wilson, q-Dolan-Grady and others satisfy this property. This provides one more (explicit Heisenberg evolution interpretation of the corresponding integrable systems.

  11. Evolution in totally constrained models: Schr\\"odinger vs. Heisenberg pictures

    CERN Document Server

    Olmedo, Javier

    2016-01-01

    We study the relation between two evolution pictures that are currently considered for totally constrained theories. Both descriptions are based on Rovelli's evolving constants approach, where one identifies a (possibly local) degree of freedom of the system as an internal time. This method is well understood classically in several situations. The purpose of this manuscript is to further analyze this approach at the quantum level. Concretely, we will compare the (Schr\\"odinger-like) picture where the physical states evolve in time with the (Heisenberg-like) picture in which one defines parametrized observables (or evolving constants of the motion). We will show that in the particular situations considered in this manuscript (the parametrized relativistic particle and a spatially flat homogeneous and isotropic spacetime coupled to a massless scalar field) both descriptions are equivalent. We will finally comment on possible issues and on the genericness of the equivalence between both pictures.

  12. 'Reading' bubble chamber pictures with the Spiral Reader eyes.

    CERN Multimedia

    1974-01-01

    Interactive techniques were widely used to study bubble chamber pictures. After a visual scanning of the pictures and a vertex measurement on a Shivamatic, the Spiral Reader allowed the track polar coordinates to be easily measured. See photo 7408137X

  13. PPG: online generation of protein pictures and animations.

    Science.gov (United States)

    Binisti, Cédric; Salim, Ahmed Ali; Tufféry, Pierre

    2005-07-01

    The protein picture generator (PPG) is an online service to generate pictures of a protein structure. Its design was conceived as an answer to the need expressed by a part of the community to have some means to produce simply complex pictures to insert in publications or in presentations. PPG can produce static or animated pictures. It can be accessed at http://bioserv.rpbs.jussieu.fr/cgi-bin/PPG.

  14. Aerial-image enables diagrams and animation to be inserted in motion pictures

    Science.gov (United States)

    Andrews, S. J., Jr.; Tressel, G. W.

    1967-01-01

    Aerial-image unit makes it possible to insert diagrams and animation into live motion pictures, and also lift an element from a confusing background by suppressing general details. The unit includes a combination of two separate lens systems, the camera-projector system and the field lens system.

  15. Problems Brought about by "Reading" a Sequence of Pictures.

    Science.gov (United States)

    Bornens, Marie-Therese

    1990-01-01

    A study investigated 4 problems of children between 3 and 7.5 years of age: difficulty in seeing the same character in different representations; the process of linking several pictures into 1 story; the correlation between the temporal order and spatial disposition of pictures; and the tendency to consider the setting of pictures as a puzzle to…

  16. 78 FR 51064 - Safety Zone; Motion Picture Production; Chicago, IL

    Science.gov (United States)

    2013-08-20

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Motion Picture Production; Chicago, IL... from portions of Chicago waterways due to the filming of a motion picture. These temporary safety zones... work, low-flying helicopter, and other hazards involved in the filming of a motion picture. DATES:...

  17. 29 CFR 541.709 - Motion picture producing industry.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Motion picture producing industry. 541.709 Section 541.709... SALES EMPLOYEES Definitions and Miscellaneous Provisions § 541.709 Motion picture producing industry... motion picture producing industry who is compensated at a base rate of at least $695 a week (exclusive...

  18. 50 CFR 27.71 - Motion or sound pictures.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Motion or sound pictures. 27.71 Section 27.71 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR... Equipment § 27.71 Motion or sound pictures. The taking or filming of any motion or sound pictures on...

  19. 78 FR 57570 - Safety Zone; Motion Picture Production; Chicago, Illinois

    Science.gov (United States)

    2013-09-19

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Motion Picture Production; Chicago... will enforce the temporary safety zone for motion picture filming in Calumet Harbor, Chicago, IL from 9... intended to ensure safety of life on navigable waters during nighttime filming of a motion picture...

  20. 单核细胞增生性李斯特菌iap基因克隆和PCR条件优化%Cloning of iap gene of Listeria monocytogenes with PCR optimization

    Institute of Scientific and Technical Information of China (English)

    贾芙蓉; 罗雁非; 方玲; 郑岚; 刘伟林; 潘洪涛; 何成彦

    2010-01-01

    目的 构建单核细胞增生性李斯特菌Listeria monocytogenes 54002-4株p60蛋白iap基因原核克隆载体.方法 利用自行设计的引物通过梯度PCR优化扩增条件,扩增出单核细胞增生性李斯特菌54002-4株的iap基因.在iap基因的5'端和3'端分别引入BamH Ⅰ和Xho Ⅰ 2个酶切位点,琼脂糖凝胶电泳分析、回收PCR产物,并将回收纯化的PCR产物与pMD 18-T载体进行连接.将该重组质粒转化人大肠杆菌JM109感受态细胞,经1 mmol/L IPTG诱导4~6 h后,观察转化效果.结果 培养无色菌落细菌,提取质粒,经PCR鉴定和核苷酸序列测定后确定获得阳性重组质粒pMD18-T-Iap.结论 通过梯度PCR摸索出最佳反应条件,建立PCR优化条件和方法,经转化获得iap基因克隆载体.%Objective To construct a prokaryotic cloning vector of invasion- associated protein (iap) gene p60 of Listeria monocytogenes. Methods Under gradient PCR amplification conditions, Listeria monocytogenes 54002-4 strain iap gene was amplified with our in-house primers. BamH Ⅰ and Xho Ⅰ sites were induced to 5' and 3' terminals of iap gene, respectively. PCR products were then analyzed and collected by agarose gel electrophoresis. Purified PCR product was connected with the vector pMD18-T. The recombinant plasmid was transformed into Escherichia coli JM109 competent cells, with transformation effect observed after 1mmol/L IPTG induction for 4-6 h. Results Colorless bacterial colony was cultured and verified to produce positive recombinant plasmid pMD18-T-Iap by PCR and nucleotide sequencing. Conclusions PCR optimization conditions and methods are established through gradient PCR. Iap gene cloning vector is obtained after transformation.

  1. MISTY PICTURE EVENT, Test Execution Report

    Science.gov (United States)

    1987-11-30

    Prather, oD ()Civ Photo Technologist MSgt Michael Yoas. USAF TRS NCO SSgt Danny Burns, USAF Administration NCO SSgt Ernesto Tagle , USAF Administration...I1 ARMTE J. Briones Evaluateý and cover 1365 E. Dunlap and 1371’. LANL J. Ylverton S-12 ARMTE R. Gomez Evaluate 1315, 1325 and 0. Melton secure SF3 1...PICTURE Observation Point. SITE TRAILER AGENCY FUNCTION NAME Admin Park Test Control DNA Test Control MAJ Walls CPT(P) Sauer SSgt Tagle SSgt Burns CDR Lund

  2. Java EE 7 the big picture

    CERN Document Server

    Coward, Danny

    2015-01-01

    Java EE 7: The Big Picture uniquely explores the entire Java EE 7 platform in an all-encompassing style while examining each tier of the platform in enough detail so that you can select the right technologies for specific project needs. In this authoritative guide, Java expert Danny Coward walks you through the code, applications, and frameworks that power the platform. Take full advantage of the robust capabilities of Java EE 7, increase your productivity, and meet enterprise demands with help from this Oracle Press resource.

  3. Picturing diversity in the ATLAS collaboration

    CERN Document Server

    Biondi, Silvia; The ATLAS collaboration

    2017-01-01

    With over 3000 members from 178 institutes, the ATLAS Collaboration is naturally diverse. However, capturing this diversity through pictures can be a challenge. Photography is a powerful tool, allowing us to reveal the faces behind a story and give the public the unique opportunity to understand and appreciate the human aspects of ATLAS's scientific research. The role of photographs in portraying the diversity of the ATLAS Collaboration and on various communication platforms will be described. Their impact will be examined, with focus on engagement of new audiences.

  4. Picturing diversity in the ATLAS experiment.

    CERN Document Server

    Biondi, Silvia; The ATLAS collaboration

    2017-01-01

    With over 3,000 members from 178 institutes, the ATLAS Collaboration is naturally diverse. However, capturing this diversity through pictures can be a challenge. Photography is a powerful tool, allowing us to reveal the faces behind a story and give the public the unique opportunity to understand and appreciate the human aspects of ATLAS’s scientific research. The role of photographs in portraying the diversity of the ATLAS Collaboration will be described. Their role on various communication platforms will be described and their impact examined, with focus on engagement of new audiences.

  5. Dwarfism and gigantism in historical picture postcards.

    Science.gov (United States)

    Enderle, A

    1998-05-01

    A collection of 893 historical picture postcards from 1900 to 1935, depicting dwarfs and giants, was analysed from medical and psychosocial viewpoints. In conditions such as 'bird headed dwarfism', achondroplasia, cretinism, so-called Aztecs or pinheads, Grebe chondrodysplasia, and acromegalic gigantism, the disorder could be diagnosed easily. In hypopituitary dwarfism, exact diagnosis was more difficult because of heterogeneity. The most common conditions depicted were pituitary dwarfism and achondroplasia. Most of those with gigantism had pituitary gigantism and acromegaly. Brothers and sisters or parents and their children provided evidence of mendelian inheritance of some of these disorders. The cards suggest that being put on show provided, at least in some cases, social benefits.

  6. Principles for a Unified Picture of Fermions

    CERN Document Server

    Nishimura, Kimihide

    2012-01-01

    The principles and conceptual foundations required for a unified picture of fermions are clarified, which in turn suggest that the standard theory may be reducible in a far simpler form. The resultant three generation model describes quarks and leptons as quasi excitations of a single chiral doublet, while electromagnetic and strong interactions as secondary interactions mediated by Nambu-Goldstone bosons originated from spontaneous violations of global SU(2) and Lorentz symmetries. The model also provides an alternative scenario for baryon and lepton asymmetries of the Universe.

  7. Venus in motion. [Mariner 10 television pictures

    Science.gov (United States)

    Anderson, J. L.; Danielson, G. E.; Evans, N.; Soha, J. M.; Belton, M. J. S.

    1978-01-01

    A comprehensive set of television pictures of Venus taken by the Mariner 10 spacecraft is presented. Included is a chronological sequence of television images illustrating the development, variety, and circulation of Venus upper-atmospheric phenomena as viewed in the near-ultraviolet. The higher-resolution images have been assembled into global mosaics to facilitate comparison. Figures and tables describing the imaging sequences have been included to provide a guide to the more complete set of 3400 Venus images on file at the National Space Science Data Center.

  8. A bilocal picture of quantum mechanics

    Science.gov (United States)

    Withers, L. P., Jr.; Narducci, F. A.

    2015-04-01

    A new, bilocal picture of quantum mechanics is developed. We show that Born’s rule supports a virtual probability for a particle to arrive, as a wave, at any two locations (but no more). We discuss two ways to implement twin detectors suitable for detecting bilocal arrivals. The bilocal picture sheds light on currents in quantum mechanics. We find there are two types of bilocal current density, whose polar form and related mean velocities are given. In the bilocal context, the definitions of both current types simplify. In the unilocal case, the two types become the usual current and a fluctuation current. Their respective mean velocity fields are the usual de Broglie-Madelung-Bohm velocity and the imaginary (osmotic) velocity. We obtain a new, probabilistic Schrödinger equation for the bilocal probability by itself, solve the example of a free particle, develop the dyadic stationary states, and find that the von Neumann equation for time-varying density of states follows directly from the new equation. We also show how to include the electromagnetic potentials in this probabilistic Schrödinger equation.

  9. A single whole-body low dose X-irradiation does not affect L1, B1 and IAP repeat element DNA methylation longitudinally.

    Directory of Open Access Journals (Sweden)

    Michelle R Newman

    Full Text Available The low dose radioadaptive response has been shown to be protective against high doses of radiation as well as aging-induced genomic instability. We hypothesised that a single whole-body exposure of low dose radiation would induce a radioadaptive response thereby reducing or abrogating aging-related changes in repeat element DNA methylation in mice. Following sham or 10 mGy X-irradiation, serial peripheral blood sampling was performed and differences in Long Interspersed Nucleic Element 1 (L1, B1 and Intracisternal-A-Particle (IAP repeat element methylation between samples were assessed using high resolution melt analysis of PCR amplicons. By 420 days post-irradiation, neither radiation- or aging-related changes in the methylation of peripheral blood, spleen or liver L1, B1 and IAP elements were observed. Analysis of the spleen and liver tissues of cohorts of untreated aging mice showed that the 17-19 month age group exhibited higher repeat element methylation than younger or older mice, with no overall decline in methylation detected with age. This is the first temporal analysis of the effect of low dose radiation on repeat element methylation in mouse peripheral blood and the first to examine the long term effect of this dose on repeat element methylation in a radiosensitive tissue (spleen and a tissue fundamental to the aging process (liver. Our data indicate that the methylation of murine DNA repeat elements can fluctuate with age, but unlike human studies, do not demonstrate an overall aging-related decline. Furthermore, our results indicate that a low dose of ionising radiation does not induce detectable changes to murine repeat element DNA methylation in the tissues and at the time-points examined in this study. This radiation dose is relevant to human diagnostic radiation exposures and suggests that a dose of 10 mGy X-rays, unlike high dose radiation, does not cause significant short or long term changes to repeat element or global DNA

  10. Testing the Snake-Detection hypothesis : Larger early posterior negativity in humans to pictures of snakes than to pictures of other reptiles, spiders and slugs

    NARCIS (Netherlands)

    van Strien, Jan W.; Franken, Ingmar H A; Huijding, Jorg

    2014-01-01

    According to the snake detection hypothesis (Isbell, 2006), fear specifically of snakes may have pushed evolutionary changes in the primate visual system allowing pre-attentional visual detection of fearful stimuli. A previous study demonstrated that snake pictures, when compared to spiders or bird

  11. Testing the Snake-Detection hypothesis : Larger early posterior negativity in humans to pictures of snakes than to pictures of other reptiles, spiders and slugs

    NARCIS (Netherlands)

    van Strien, Jan W.; Franken, Ingmar H A; Huijding, Jorg

    2014-01-01

    According to the snake detection hypothesis (Isbell, 2006), fear specifically of snakes may have pushed evolutionary changes in the primate visual system allowing pre-attentional visual detection of fearful stimuli. A previous study demonstrated that snake pictures, when compared to spiders or bird

  12. Enhanced recognition of memorable pictures in ultra-fast RSVP.

    Science.gov (United States)

    Broers, Nico; Potter, Mary C; Nieuwenstein, Mark R

    2017-05-08

    Long-term recognition memory for some pictures is consistently better than for others (Isola, Xiao, Parikh, Torralba, & Oliva, IEEE Transaction on Pattern Analysis and Machine Intelligence (PAMI), 36(7), 1469-1482, 2014). Here, we investigated whether pictures found to be memorable in a long-term memory test are also perceived more easily when presented in ultra-rapid RSVP. Participants viewed 6 pictures they had never seen before that were presented for 13 to 360 ms per picture in a rapid serial visual presentation (RSVP) sequence. In half the trials, one of the pictures was a memorable or a nonmemorable picture and perception of this picture was probed by a visual recognition test at the end of the sequence. Recognition for pictures from the memorable set was higher than for those from the nonmemorable set, and this difference increased with increasing duration. Nonmemorable picture recognition was low initially, did not increase until 120 ms, and never caught up with memorable picture recognition performance. Thus, the long-term memorability of an image is associated with initial perceptibility: A picture that is hard to grasp quickly is hard to remember later.

  13. Pictures from Year Two CNEC and CVT Measurements

    Energy Technology Data Exchange (ETDEWEB)

    Hutchinson, Jesson D. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Bahran, Rian Mustafa [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); McKenzie, George Espy [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Cutler, Theresa Elizabeth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-08-30

    Below are all of the pictures for the CNEC and CVT measurements performed at the DAF in July 2016. In total there are 165 pictures. The photos on pages 2-105 were taken during the first week of measurements and the photos on pages 106-165 were taken during the second week of measurements. Many photos are applicable to both sets, which is why it is best to keep the entire set together. For most configurations, a description of the configuration was written on a white board; photos of the measurement setup were taken, then a photo of the white board was taken. For example, the pictures on pages 6-19 (which precede a white board picture on page 20) are of the configuration with Rocky Flats Shells 1-2 surrounded by 4 AmLi sources, which is listed on the white board picture on page 20. In some cases, the white board picture precedes the configuration pictures.

  14. Error resilient video coding using virtual reference picture

    Science.gov (United States)

    Zhang, Guanjun; Stevenson, Robert L.

    2005-03-01

    Due to widely used motion-compensated prediction coding, errors propagate along decoded video sequence and may result in severe quality degradation. Various methods have been reported to address this problem based on the common idea of diversifying prediction references. In this paper, we present an alternative way of concealing the references pictures errors. A generated virtual picture is used as a reference instead of an actual sequence picture in the temporal prediction. The virtual reference picture is generated in a way to filter damaged parts of previously decoded pictures so that the decoder can still get a clean reference picture in case of errors. Coding efficiency is effected due to the fact that the virtual reference is less correlated to the currently encoded picture. The simulations on H.264 codec have shown quality improvement of the proposed method over intra-coded macroblock refreshment. It can be used on any motion-compensated video codec to combat channel errors.

  15. Motion Pictures and Motion-Picture Equipment: A Handbook of General Information. Bulletin, 1919, No. 82

    Science.gov (United States)

    Reynolds, F. W.; Anderson, Carl

    1920-01-01

    Motion-picture films have come to be recognized quite generally as a valuable and practical means of instruction in schools, college, and universities and for clubs and societies organized for educational purposes. The number of persons making such use of them is now very large and constantly becoming larger. To all these, a handbook of general…

  16. [Radiologic picture of maxillary sinus aspergilloma].

    Science.gov (United States)

    Kaczmarek, I; Bilska, J; Osmola, K; Nowaczyk, M T

    2010-06-01

    Mycotic infection of paranasal sinus could be the etiological factor of chronic sinusitis. The increase in number of fungal sinusitis cases have been reported recently among nonimmunocompromised patient after endodontic treatment of maxillary teeth. Nonspecific clinical signs and incorrect radiologic pictures interpretation as well as loss of therapeutic standards seems to be the cause of false negative diagnosis and difficulties in treatment of fungal sinusitis. Clinical and radiological picture of maxillary sinus aspergillosis was described in this paper. In the period of 2006-2009 in the Department of Maxillo-Facial Surgery 19 patient with fungal maxillary sinusitis was treated. The endodontic treatment of maxillary teeth of the related side was performed previously in 80% examined cases. In 2 cases there were immunocompromised patients with immunosuppressive treatment. In 16 cases patients were referred to our Department due to metallic foreign body of the maxillary sinus. Routine diagnostic radiological imaging was performed in each case: paranasal sinus view--Water's view and panoramic radiograph (orthopantomograph). In 4 cases imaging was extended with computer tomography (CT) visualization. The surgical treatment was performed in each case. The final diagnosis was puted on histopathological examination and fungal culture. In 16 cases of analysed group histopathological examination and fungal culture revealed aspergilosis. In 2 cases fungal culture was negative, but histopathology slices confirm presence of hyphae of Aspergillus. In 1 case the root canal sealer was found in the maxillary sinus. In none case invasive form of aspergillosis was confirmed. In all cases Water's view of paranasal sinuses and ortopantomograph showed partially or totally clouded sinus with well-defined, single or multifocal radiopaque object similar to metallic foreign body. Characteristic finding in CT imaging was well-defined radiodence concretions that have been attributed to

  17. Thyroid hormones concentrations and ECG picture in the dog.

    Science.gov (United States)

    Pasławska, U; Noszczyk-Nowak, A; Kungl, K; Bioły, K; Popiel, J; Nicpoń, J

    2006-01-01

    Disorders of the thyroid gland activity are the most commonly encountered disturbances of endocrine origin in the dog. Hypo- or hyperthyroidism may disturb the function of the cardiovascular system and cause arrhythmias. The aim of this study was to evaluate the influence of thyroid gland activity on electrocardiogram (ECG) picture in the dog by comparing ECG curves of healthy dogs, dogs with hypothyroidism and dogs with cardiac insufficiency caused by endocardiosis of the mitral valve. The study was performed on 38 dogs, patients of the Department of Internal and Parasitic Diseases with Clinic for Horses, Dogs and Cats in Wrocław. The animals were assigned to 3 groups: Group I--control group, 13 clinically healthy dogs; Group II--14 dogs with diagnosed cardiac insufficiency caused by endocardiosis of the mitral valve; Group III--11 dogs with hypothyroidism. Clinical examination of the animals was conducted according to the following pattern: anamnesis, general clinical examination, cardiological examination (ECG, USG of the heart) and laboratory analysis (triacylglycerydes, cholesterol, T3, T4, FT4). In this study, the significant influence of thyroid gland activity on ECG picture of the evaluated dogs was found. In the dogs with hypothyroidism a decrease in the sino-atrial node activity was observed, which led to decreased heart rate. In dogs with hypothyroidism, the innerheart conduction was reduced, which was demonstrated by prolongation of the P wave, QRS complex and the QT interval.

  18. A New Evolutionary Picture for CVs and LMXBs

    CERN Document Server

    King, A R; King, Andrew R.; Schenker, Klaus

    2001-01-01

    We consider an alternative to the standard picture of CV and LMXB evolution, namely the idea that most CVs (and by extension LMXBs) may not yet have had time to evolve to their theoretical minimum orbital periods. We call this the Binary Age Postulate (BAP). The observed short-period cutoff in the CV histogram emerges naturally as the shortest period yet reached in the age of the Galaxy, while the post-minimum-period space density problem is removed. The idea has similar desirable consequences for LMXBs. In both cases systems with nuclear-evolved secondary stars form a prominent part of the short-period distributions. Properties such as the existence and nature of ultrashort-period systems, and the spread in mass transfer rates at a given orbital period, are naturally reproduced.

  19. The clinical picture of neonatal infection with Pantoea species.

    Science.gov (United States)

    Van Rostenberghe, H; Noraida, R; Wan Pauzi, W I; Habsah, H; Zeehaida, M; Rosliza, A R; Fatimah, I; Nik Sharimah, N Y; Maimunah, H

    2006-04-01

    Pantoea infections are uncommon in humans. Most reports have involved adults or children after thorn injuries. There are only a few reports of systemic infections with Pantoea. This is the first report of the clinical picture of systemic Pantoea spp. infection in neonates as observed during an outbreak in a neonatal intensive care unit caused by infected parenteral nutrition solutions. Even though detected early, the infections had a fulminant course, causing septicemic shock and respiratory failure. Pulmonary disease was prominent and presented mainly as pulmonary hemorrhage and adult respiratory distress syndrome. The organism was sensitive to most antibiotics used in neonatal intensive care units, but the clinical response to antibiotic therapy was poor. The fatality rate was very high: 7 out of 8 infected infants succumbed to the infection (87.5%).

  20. Improvements in Climate Simulation with Modifications to the Tiedtke Convective Parameterization in the Grid-Point Atmospheric Model of IAP LASG (GAMIL)

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The grid-point atmospheric model of IAP LASG (GAMIL) was developed in and has been evaluated since early 2004. Although the model shows its ability in simulating the global climate, it suffers from some problems in simulating precipitation in the tropics. These biases seem to result mainly from the treatment of the subgrid scale convection, which is parameterized with Tiedtke's massflux scheme (or the Zhang-McFarlane scheme, as an option) in the model. In order to reduce the systematic biases, several modifications were made to the Tiedtke scheme used in GAMIL, including (1) an increase in lateral convective entrainment/detrainment rate for shallow convection, (2) inclusion of a relative humidity threshold for the triggering of deep convection, and (3) a reduced efficiency for the conversion of cloud water to rainwater in the convection scheme.Two experiments, one with the original Tiedtke scheme used in GAMIL and the other with the modified scheme, were conducted to evaluate the performance of the modified scheme in this study. The results show that both the climatological mean state, such as precipitation, temperature and specific humidity, and interannual variability in the model simulation are improved with the use of this modified scheme. Results from several additional experiments show that the improvements in the model performance in different regions mainly result from either the introduction of the relative humidity threshold for triggering of the deep convection or the suppressed shallow convection due to enhanced lateral convective entrainment/detrainment rates.

  1. 单核细胞增生性李斯特菌iap基因的原核表达%Prokaryotic Expression of iap Gene from Listeria monocytogenes

    Institute of Scientific and Technical Information of China (English)

    区燕宜; 徐成刚; 叶贺佳; 吴晓薇; 廖明

    2008-01-01

    该研究利用自行设计的引物通过PCR方法扩增出单核细胞增生性李斯特菌 Listeria monocytogenes C5305 株的iap基因,在iap基因的5'端和3'端分别引入EcoR Ⅰ和Xho Ⅰ 2 个酶切位点并将其克隆到pET-28a表达载体上,经PCR鉴定、酶切鉴定和核苷酸序列测定后获得重组质粒 pET-28a-iap,将该重组质粒转化人大肠杆菌BL21 (DE3)pLysS,经1 mmol/LIPTG诱导4~6 h后,通过SDS-PAGE及Western-blotting鉴定,证明该基因得到表达,表达产物相对分子质量约为60 000,以可溶形式存在.

  2. Sensitivity of the Grid-point Atmospheric Model of IAP LASG (GAMIL1.1.0) Climate Simulations to Cloud Droplet Effective Radius and Liquid Water Path

    Institute of Scientific and Technical Information of China (English)

    LI Lijuan; Yuqing WANG; WANG Bin; ZHOU Wianjun

    2008-01-01

    This paper documents a study to examine the sensitivity to cloud droplet effective radius and liquid water path and the alleviation the energy imbalance at the top of the atmosphere and at the surface in the latest version of the Grid-point Atmospheric Model of the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics (LASG), Institute of Atmospheric Physics (IAP) (GAMILI.I.0). Considerable negative biases in all flux components, and thus an energy imbalance, are found in GAMIL1.1.0. In order to alleviate the energy imbalance, two modifications, namely an increase in cloud droplet effective radius and a decrease in cloud liquid water path, have been made to the cloud properties used in GAMIL. With the increased cloud droplet effective radius, the single scattering albedo of clouds is reduced, and thus the reflection of solar radiation into space by clouds is reduced and the net solar radiation flux at the top of the atmosphere is increased. With the reduced cloud optical depth, the net surface shortwave radiation flux is increased, causing a net warming over the land surface. This results in an increase in both sensible and latent heat fluxes over the land regions, which is largely balanced by the increased terrestrial radiation fluxes. Consequently, the energy balance at the top of atmosphere and at the surface is achieved with energy flux components consistent with available satellite observations.

  3. Picture analysing method of slag foaming behaviour

    Energy Technology Data Exchange (ETDEWEB)

    Juhart, M.; Peter, M.; Koch, K. [Technische Univ. Clausthal, Clausthal-Zellerfeld (Germany). Inst. fuer Metallurgy; Lamut, J. [Faculty of Natural Science and Technology, Univ. Ljubljana, Ljubljana (Slovenia)

    2001-03-01

    Hot tests of foaming behaviour of steelmaking slags were conducted on a laboratory scale up to 1760 C using a Tammann furnace. The foaming behaviour of the slags was quantified on the basis of a new measuring method. The volume increase and the progress of the foaming process can be continuously observed and calculated by means of picture analysis. The gas content of foaming slags was compared with the results of the measurements performed in steel plants. The influence of the magnesia content on the foaming behaviour is investigated. The chemical composition of the slag is beside the CO evolution the decisive factor influencing slag foaming behaviour. The highest volume increase values observed lie in the region of 2500% in relation to the initial volume. (orig.)

  4. Random Walk Picture of Basketball Scoring

    CERN Document Server

    Gabel, Alan

    2011-01-01

    We present evidence, based on play-by-play data from all 6087 games from the 2006/07--2009/10 seasons of the National Basketball Association (NBA), that basketball scoring is well described by a weakly-biased continuous-time random walk. The time between successive scoring events follows an exponential distribution, with little memory between different scoring intervals. Using this random-walk picture that is augmented by features idiosyncratic to basketball, we account for a wide variety of statistical properties of scoring, such as the distribution of the score difference between opponents and the fraction of game time that one team is in the lead. By further including the heterogeneity of team strengths, we build a computational model that accounts for essentially all statistical features of game scoring data and season win/loss records of each team.

  5. Hard diffraction in the QCD dipole picture

    CERN Document Server

    Bialas, A

    1995-01-01

    Using the QCD dipole picture of the BFKL pomeron, the gluon contribution to the cross-section for single diffractive dissociation in deep-inelastic high-energy scattering is calculated. The resulting contribution to the proton diffractive structure function integrated over t is given in terms of relevant variables, x_{\\cal P}, Q^2, and \\beta = x_{Bj}/x_{\\cal P}. It factorizes into an explicit x_{\\cal P}-dependent Hard Pomeron flux factor and structure function. The flux factor is found to have substantial logarithmic corrections which may account for the recent measurements of the Pomeron intercept in this process. The triple Pomeron coupling is shown to be strongly enhanced by the resummation of leading logs. The obtained pattern of scaling violation at small \\beta is similar to that for F_2 at small x_{Bj}.

  6. Dwarfism and gigantism in historical picture postcards.

    Science.gov (United States)

    Enderle, A

    1998-01-01

    A collection of 893 historical picture postcards from 1900 to 1935, depicting dwarfs and giants, was analysed from medical and psychosocial viewpoints. In conditions such as 'bird headed dwarfism', achondroplasia, cretinism, so-called Aztecs or pinheads, Grebe chondrodysplasia, and acromegalic gigantism, the disorder could be diagnosed easily. In hypopituitary dwarfism, exact diagnosis was more difficult because of heterogeneity. The most common conditions depicted were pituitary dwarfism and achondroplasia. Most of those with gigantism had pituitary gigantism and acromegaly. Brothers and sisters or parents and their children provided evidence of mendelian inheritance of some of these disorders. The cards suggest that being put on show provided, at least in some cases, social benefits. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 PMID:9764085

  7. The application of holography as a real-time three-dimensional motion picture camera

    Science.gov (United States)

    Kurtz, R. L.

    1973-01-01

    A historical introduction to holography is presented, as well as a basic description of sideband holography for stationary objects. A brief theoretical development of both time-dependent and time-independent holography is also provided, along with an analytical and intuitive discussion of a unique holographic arrangement which allows the resolution of front surface detail from an object moving at high speeds. As an application of such a system, a real-time three-dimensional motion picture camera system is discussed and the results of a recent demonstration of the world's first true three-dimensional motion picture are given.

  8. What interests them in the pictures?--differences in eye-tracking between rhesus monkeys and humans.

    Science.gov (United States)

    Hu, Ying-Zhou; Jiang, Hui-Hui; Liu, Ci-Rong; Wang, Jian-Hong; Yu, Cheng-Yang; Carlson, Synnöve; Yang, Shang-Chuan; Saarinen, Veli-Matti; Rizak, Joshua D; Tian, Xiao-Guang; Tan, Hen; Chen, Zhu-Yue; Ma, Yuan-Ye; Hu, Xin-Tian

    2013-10-01

    Studies estimating eye movements have demonstrated that non-human primates have fixation patterns similar to humans at the first sight of a picture. In the current study, three sets of pictures containing monkeys, humans or both were presented to rhesus monkeys and humans. The eye movements on these pictures by the two species were recorded using a Tobii eye-tracking system. We found that monkeys paid more attention to the head and body in pictures containing monkeys, whereas both monkeys and humans paid more attention to the head in pictures containing humans. The humans always concentrated on the eyes and head in all the pictures, indicating the social role of facial cues in society. Although humans paid more attention to the hands than monkeys, both monkeys and humans were interested in the hands and what was being done with them in the pictures. This may suggest the importance and necessity of hands for survival. Finally, monkeys scored lower in eye-tracking when fixating on the pictures, as if they were less interested in looking at the screen than humans. The locations of fixation in monkeys may provide insight into the role of eye movements in an evolutionary context.

  9. Picture-books: first structured reading materials for children

    Directory of Open Access Journals (Sweden)

    Ivana Martinović

    2012-11-01

    Full Text Available Early literacy has recently become a current topic, and there’s a widespread belief that literacy startsdeveloping almost as soon as the child is born, if the child is surrounded with adequate materials and persons who will motivate the development of literacy. The first structured reading materials that a child interacts with are picture-books. It is usually the first contact a child has with literature and a written word in general, and it happens during childhood, the child's most sensitive period, which is why it is important to pay special attention to the quality of picture-books. Croatian picture-books published till the early 80ies of the past century have been investigated to a some extent. However, the picture-books found on the Croatian market and in the libraries in the past 30 years have been the subject of research only sporadically. There's little data on the quality and features of this multifunctional material that is of such great importance for children. The aim of the paper is to give an overview of the relevant data found in literature on the historical development of picture-book publishing, their features, functions they help develop, their age-appropriateness, and quality. The paper presents research results stemming from the analysis of the Croatian Children's Book Centre documentation on contemporary picture-book publishing and data on the language of picture-books that are the result of a picture-book corpus study made as part of the PhD research by the author. The data on contemporary authors and illustrators was obtained by analysing the documentation of the Croatian Library Association, Commission for library services for children and youth. The language of the picture-book corpus was analysed using a computer programme, i.e. the analysis was conducted of the lexical diversity of picture-books for three-year olds. The picture-books have not been investigated from the linguistic perspective before, which makes this

  10. An Evaluation of Extended Validation and Picture-in-Picture Phishing Attacks

    Science.gov (United States)

    Jackson, Collin; Simon, Daniel R.; Tan, Desney S.; Barth, Adam

    In this usability study of phishing attacks and browser anti-phishing defenses, 27 users each classified 12 web sites as fraudulent or legitimate. By dividing these users into three groups, our controlled study measured both the effect of extended validation certificates that appear only at legitimate sites and the effect of reading a help file about security features in Internet Explorer 7. Across all groups, we found that picture-in-picture attacks showing a fake browser window were as effective as the best other phishing technique, the homograph attack. Extended validation did not help users identify either attack. Additionally, reading the help file made users more likely to classify both real and fake web sites as legitimate when the phishing warning did not appear.

  11. Fashion pictures and women pictures in French women magazine. Normatives parades or strategic masquerade?

    Directory of Open Access Journals (Sweden)

    Justine MARILLONNET

    2014-12-01

    Full Text Available This article proposes to study the fashion pictures within a representative sample of French women magazines. Based on the method of “sémiologie des indices”, used to analyze a corpus of woman’s body and fashion staged, this paper addresses the issue of new functions granted to the stereotyping process. Starting to the assumption of a contract between audience and media, this analysis shows that the gender stereotype may be prescribed, up to a caricature of the womanhood, to the female readers identified as co-producers of the media discourse. Demonstrating both the co-existence of a plurality of gender representations in its pictures and their variability, this work proposes the concept of strategic masquerade to apprehend the possible new functions for the process of gender stereotyping in media.

  12. Enhanced Choice for Viewing Cocaine Pictures in Cocaine Addiction

    Energy Technology Data Exchange (ETDEWEB)

    Moeller, S.J.; Goldstein, R.; Moeller, S.J.; Maloney, T. Parvaz, M.A.; Dunning, J.P.; Alia-Klein, N.; Woicik, P.A.; Hajcak, G.; Telang, F.; Wang, G.-J.; Volkow, N.D.; Goldstein, R.Z.

    2009-02-01

    Individuals with cocaine use disorder (CUD) chose cocaine over nondrug rewards. In two newly designed laboratory tasks with pictures, we document this modified choice outside of a cocaine administration paradigm. Choice for viewing cocaine, pleasant, unpleasant, or neutral pictures-under explicit contingencies (choice made between two fully visible side-by-side images) and under more implicit contingencies (selections made between pictures hidden under flipped-over cards)-was examined in 20 CUD and 20 matched healthy control subjects. Subjects also provided self-reported ratings of each picture's pleasantness and arousal. Under both contingencies, CUD subjects chose to view more cocaine pictures than control subjects, group differences that were not fully explained by the self-reported picture ratings. Furthermore, whereas CUD subjects choice for viewing cocaine pictures exceeded choice for viewing unpleasant pictures (but did not exceed choice for viewing pleasant pictures, in contrast to their self-reported ratings), healthy control subjects avoided viewing cocaine pictures as frequently as, or even more than, unpleasant pictures. Finally, CUD subjects with the most cocaine viewing selections, even when directly compared with selections of the pleasant pictures, also reported the most frequent recent cocaine use. Enhanced drug-related choice in cocaine addiction can be demonstrated even for nonpharmacologic (pictorial) stimuli. This choice, which is modulated by alternative stimuli, partly transcends self-reports (possibly indicative of a disconnect in cocaine addiction between self-reports and objective behavior) to provide an objective marker of addiction severity. Neuroimaging studies are needed to establish the neural underpinnings of such enhanced cocaine-related choice.

  13. “Surprised!” Telling the pictures. Can the illustrations in picture books promote language acquisition?

    Directory of Open Access Journals (Sweden)

    Sandie Mourão

    2009-11-01

    Full Text Available Este artigo procura apresentar os resultados da re-análise dos dados recolhidos em dois projectos de investigaçãoacçãosobre a utilização de álbuns em língua inglesa nas aulas de Inglês da Educação Pré-Escolar em Portugal.Dois álbums forum usados, demonstrando diferentes interacções entre texto e imagem, ‘paralela’ e ‘interdependente’. Transcrições de gravações de horas do conto com estes livros foram categorizadas de acordo com asfalas em Inglês a que o texto ou imagem deram origem. Os resultados indicam que a linguagem que as criançasaprendem de facto, com os livros ‘inter-dependentes’ (onde a história escrita é diferente da história ilustrada émais rica e as próprias crianças tomam um papel mais activo na criação de um significado. As implicações destesresultados são discutidas.The following article presents the findings of a re-analysis of data from two action research projects investigatingthe use of English picture books in Pre-school English classes in Portugal. Two picture books were used, eachrepresenting parallel and interdependent storytelling models. Audio tapescripts of the picture book read aloudswere categorised according to the utterances prompted by the verbal and visual texts. Results show that foreignlanguage acquisition is extended when both the verbal and visual texts of a picture book are used for languageinput and that children are more actively involved in meaning making. Implications are discussed.

  14. P1-10: The Association between Colors and Emotions

    Directory of Open Access Journals (Sweden)

    Yen-Yu Chen

    2012-10-01

    Full Text Available Wexner (1954 Journal of Applied Psychology 38 432–435 demonstrated colors were associated with specific emotions. Colors have many meanings, such as that red can lead to induce positive or negative emotions (Kaya & Epps, 2011 College Student Journal 38 396–406. This study extends previous findings and aims to investigate two questions, (1 whether colors are associated with the emotions of pictures in IAPS (International Affective Picture System and (2 whether perceiving IAPS consciously and unconsciously has different emotion associations. We replaced facial expressions with pictures of IAPS as stimuli. Five colors (black, red, yellow, blue, and white and 3 categories of IAPS (fear, awe, and amusement were manipulated in this study. Pictures were displayed in different durations to manipulate conscious (250 ms and unconscious (33 ms visual stimuli (Manuel & Pedro, 2009 Behavior Research Method 41 184–191 in two experiments. Participants were required to select the most suitable color at their first glance when the pictures of IAPS were presented, and vice versa. Results showed that overall association between colors and pictures of IAPS was weak but the association pattern was meaningful. It concluded (1 black and red colors are associated with the fearful emotion, and blue color is associated with the happy emotion; (2 white colors do not associate with the fear emotion, which is incongruent with the previous study (Osvaldo & Paul, 2007 Colour: Design & Creativity 1 1–20; (3 participants did not perform differently between conscious and unconscious stimulus conditions.

  15. The sound picture of the Saami shamanic drum

    Directory of Open Access Journals (Sweden)

    Rolf Kristoffersson

    1991-01-01

    Full Text Available Research on the Saami shamanic drum has mainly concerned the pictorial world of the drumhead. Therefore, studying the sound picture may give new insights into the Saami Shamanic drum. In my study of the Saami drum I have tried to find the answer to two questions: 1 Is it possible to detect the sound pictogram from some of the drums preserved? 2 Are there marks of usage which might indicate what kind of sounds the users preferred? A comparison of the different drums shows that the signs of usage are surprisingly consistent. The drum sounds reach the receptive organs in the human ear in a range of low but strong tones, with low frequencies but high amplitude. This means that more energy is transferred into the nervous system than with various other types of instrumental sounds.

  16. On two pictures in the heuristic approach to gravity

    CERN Document Server

    Nikishov, A I

    2007-01-01

    We examine the heuristic approach to constant gravitational field by Dehnen, H\\"onl and Westpfahl, extending it everywhere beyond linear approximation. Then it becomes flexible to accommodate possible modifications of General Relativity. We have found that two pictures introduced in the related paper by Thirring are helpful in better understanding some features of gravitation. In particular, this approach suggest that the privileged system for constant gravitational field must be the isotropic one and that the requirement of gauge invariance in gravitation theory may be a luxury; it is sufficient to take care that the nonphysical degrees of freedom do not invalidate calculations. It follows from this approach that gravitational constant should depend on gravitational field and some universality in the form of metric of an asymmetric body is suggested.

  17. Phase space picture of quantum mechanics group theoretical approach

    CERN Document Server

    Kim, Y S

    1991-01-01

    This book covers the theory and applications of the Wigner phase space distribution function and its symmetry properties. The book explains why the phase space picture of quantum mechanics is needed, in addition to the conventional Schrödinger or Heisenberg picture. It is shown that the uncertainty relation can be represented more accurately in this picture. In addition, the phase space picture is shown to be the natural representation of quantum mechanics for modern optics and relativistic quantum mechanics of extended objects.

  18. 大学生对不同类型中性图片情绪效价的评定%Assessment of emotional valence of the neutral pictures: it depends on the category

    Institute of Scientific and Technical Information of China (English)

    王越; 王异芳

    2013-01-01

    目的 探讨大学生对自然、植物、动物、人类、文化、死亡废物、食物和电脑构图8类中性图片诱发中性情绪的不同效果及其性别差异,旨在发现对于男、女性而言,哪些类别的图片能更好地诱发中性情绪.方法 试验材料选自简易版国际情绪图片库(330张),用E-prime软件编写程序,将186名(男性78名,女性108名)大学生对135张中性图片平静程度的评定等级进行分析.结果 植物[(6.87±1.53)分]、自然[(7.00±1.73)分]和文化[(6.93±1.37)分]诱发中性情绪的效果显著优于人类[(5.89±1.49)分]、电脑构图[(5.94±1.93)分]和食物[(5.87±2.03)分,(P<0.05)],人类、电脑构图和食物的诱发效果又显著优于动物[(5.03±1.70)分]和死亡废物[(4.71±1.94)分,(P<0.05)];男性对死亡废物、人类和动物三个类别反应的平静程度显著高于女性(P<0.05),男、女性对其他类别的反应不存在性别差异.结论 植物、自然和文化三类中性图片诱发中性情绪最理想.本研究为情绪研究以及临床上选取和使用相关图片获得中性情绪提供一定的实证依据.%Objective To explore which category of pictures could induce neutral emotion better for male and female respectively,and investigate the effects of inducing neutral emotion with eight categories of neutral pictures,including the nature,plants,animals,humans,culture,death-waste,food and computer graphics.Methods Using selected stimuli from the simple version (revised by Huang and Luo(2004)) of the International Affective Picture System (IAPS),the rating of calm-mood degree were collected for 135 neutral pictures based on 186 undergraduate students (78 male and 108 female).Results The pictures in the categories of plants(6.87 ±1.53),nature(7.00 ± 1.73) and culture(6.93 ± 1.37) induced neutral emotion significantly better than human (5.89 ± 1.49),computer graphics (5.94 ± 1.93) and food (5.87 ± 2.03) (P < 0.05) which were better

  19. A Pedagogical Experiment Using Bubble Chamber Pictures

    CERN Multimedia

    2002-01-01

    We have taken, in October 1981, 20.000 pictures of proton-proton interactions at 5 GeV/c in order to get some clean elastic events which can be easily studied by high school students. The purpose is to illustrate, by actual measurements of these real events, some basic concepts of relativistic mechanisms. This experiment will be an extension of our previous one, performed with HBC 2m events taken at 2 GeV/c. In 1980, all french lycees were provided with large size reproduction of HBC 2m events. Before distribution they were carefully selected and severe kinematical cuts were made. The students measured track curvatures by template, and checked the necessity and the validity of relativistic mechanics by computing the energy balance using non-relativistic and relativistic formulae. No practical problems have been encountered during this experiment and the pedagogical results are encouraging. This new sample of events will be interesting because they are relativistic than the old ones although with the same curv...

  20. [Patients' experiences and picture processes during the art therapy in a psychosomatic day hospital].

    Science.gov (United States)

    Oster, Jörg; Poetsch, Stephanie; Danner-Weinberger, Alexandra; von Wietersheim, Jörn

    2014-02-01

    The aim of this study was the examination of the experiences of patients participating in an art therapy during a psychosomatic day hospital. The data basis were 15 transliterated interviews from the end of the treatment, conducted with a presentation of the pictures painted in the art therapy sessions, as well as the digitised pictures. The evaluation was done with a qualitative analysis of the interviews and an analysis of the pictures, using a specially-developed category system. In the art therapy, most part of the pa-tients dealt with own conflicts. Nearly all pa-tients benefitted from the art therapy and indicated an improvement of their feeling. The picture processes are different; at the beginning, wishes and familiar techniques dominated. Pictures of turning points differed in their dimensions. The art therapy was seen as a part of the complete treatment in which several therapies assembled. The final interviews were experienced as helpful for further reflections. © Georg Thieme Verlag KG Stuttgart · New York.

  1. ViscumTT induces apoptosis and alters IAP expression in osteosarcoma in vitro and has synergistic action when combined with different chemotherapeutic drugs.

    Science.gov (United States)

    Kleinsimon, Susann; Kauczor, Gwenda; Jaeger, Sebastian; Eggert, Angelika; Seifert, Georg; Delebinski, Catharina

    2017-01-07

    Osteosarcoma is the most common bone tumor and is associated with a poor prognosis. Conventional therapies, surgery and chemotherapy, are still the standard but soon reach their limits. New therapeutic approaches are therefore needed. Conventional aqueous mistletoe extracts from the European mistletoe (Viscum album L.) are used in complementary cancer treatment. These commercial extracts are water-based and do not include water-insoluble compounds such as triterpenic acids. However, both hydrophilic and hydrophobic triterpenic acids possess anti-cancer properties. In this study, a whole mistletoe extract viscumTT re-created by combining an aqueous extract (viscum) and a triterpene extract (TT) was tested for its anti-cancer potential in osteosarcoma. Two osteosarcoma cell lines were treated with three different mistletoe extracts viscum, TT and viscumTT to compare their apoptotic potential. For this purpose, annexin/PI staining and caspase-3, -8 and -9 activity were investigated by flow cytometry. To determine the mechanism of action, alterations in expression of inhibitors of apoptosis (IAPs) were detected by western blot. Apoptosis induction by co-treatment of viscum, TT and viscumTT with doxorubicin, etoposide and ifosfamide was examined by flow cytometry. In vitro as well as ex vivo, the whole mistletoe extract viscumTT led to strong inhibition of proliferation and synergistic apoptosis induction in osteosarcoma cells. In the investigations of mechanism of action, inhibitors of apoptosis such as XIAP, BIRC5 and CLSPN showed a clear down-regulation after viscumTT treatment. In addition, co-treatment with doxorubicin, etoposide and ifosfamide further enhanced apoptosis induction, also synergistically. ViscumTT treatment results in synergistic apoptosis induction in osteosarcoma cells in vitro and ex vivo. Additionally, conventional standard chemotherapeutic drugs such as doxorubicin, etoposide and ifosfamide were able to dramatically enhance apoptosis induction

  2. NUMERICAL SIMULATIONS OF EFFECTS OF LAND SURFACE PROCESSES ON CLIMATE——IMPLEMENTING OF SSiB IN IAP/LASG AGCM AND ITS PERFORMANCE

    Institute of Scientific and Technical Information of China (English)

    孙岚; 吴国雄; 孙菽芬

    2001-01-01

    This is an investigation of exchanges of energy and water between the atmosphere and the vegetated continents, and the impact of and mechanisms for land surface-atmosphere interactions on hydrological cycle and general circulation by implementing the Simplified Simple Biosphere (SSiB) model in a modified version of IAP/LASG global spectral general model (L9R15 AGCM).This study reveals that the SSiB model produces a better partitioning of the land surface heat and moisture fluxes and its diurnal variations, and also gives the transport of energy and water among atmosphere, vegetation and soil explicitly and realistically. Thus the coupled SSiB-AGCM runs lead to the more conspicuous improvement in the simulated circulation, precipitation, mean water vapor content and its transport, particularly in the Asian monsoon region in the real world than CTL-AGCM runs. It is also pointed out that both the implementation of land surface parameterizations and the variations in land surface into the GOALS model have greatly improved hydrological balance over continents and have a significant impact on the simulated climate,particularly over the massive continents.Improved precipitation recycling model was employed to verify the mechanisms for land surface hydrology parameterizations on hydrological cycle and precipitation climatology in AGCM.It can be argued that the recycling precipitation rate is significantly reduced, particularly in the arid and semi-arid region of the boreal summer hemisphere, coincident with remarkable reduction in evapotranspiration over the continental area. Therefore the coupled SSiB-AGCM runs reduce the bias of too much precipitation over land surface in most AGCMs, thereby bringing the simulated precipitation closer to observations in many continental regions of the world than CTL-AGCM runs.

  3. Expression of human IAP-like protein in skeletal muscle: a possible explanation for the rare incidence of muscle fiber apoptosis in T-cell mediated inflammatory myopathies.

    Science.gov (United States)

    Li, M; Dalakas, M C

    2000-07-01

    In Polymyositis (PM) and sporadic Inclusion Body Myositis (s-IBM), the CD8(+) cytotoxic T cells invade the muscle membrane and release perforin and granzyme B to induce cell death. Although granzyme B is a direct activator of executioner caspases, there is no convincing evidence of apoptosis in the muscle fibers of these patients. To search for an explanation, we examined the muscle expression of the human IAP-Like Protein (hILP), an evolutionarily conserved cell death suppressor, that exerts major anti-apoptotic effects by inhibiting the executioner caspases. Muscle biopsy specimens from patients with inflammatory myopathies and controls were studied with: (a) immunocytochemistry using antibodies against hILP and caspase-3 in single and double-labeled confocal laser microscopy; (b) immunoblotting of muscle extracts immunoreacted with anti-hILP antibodies; and (c) subcellular fractionation of muscle lysates immunoreacted with antibodies against hILP. We found that hILP is expressed on the sarcolemmal region and co-localizes with dystrophin. Caspase-3 is undetectable. Subcellular fractionation of the muscle specimens confirmed that hILP is a membrane-associated protein. By immunoblotting, the 57 kD hILP was abundantly expressed in the normal as well as the diseased muscles. We conclude that in s-IBM and PM the expression of hILP, a major cell death suppressor, on the muscle membrane may prevent the induction of apoptosis by the autoinvasive cytotoxic T cells on the cell surface, by inhibiting the caspase activation.

  4. Two Modes of the Silk Road Pattern and Their Interannual Variability Simulated by LASG/IAP AGCM SAMIL2.0

    Institute of Scientific and Technical Information of China (English)

    SONG Fengfei; ZHOU Tianjun; WANG Lu

    2013-01-01

    In this study,two modes of the Silk Road pattern were investigated using NCEP2 reanalysis data and the simulation produced by Spectral Atmospheric Circulation Model of IAP LASG,Version 2 (SAMIL2.0) that was forced by SST observation data.The horizontal distribution of both modes were reasonably reproduced by the simulation,with a pattern correlation coefficient of 0.63 for the first mode and 0.62 for the second mode.The wave train was maintained by barotropic energy conversion (denoted as CK) and baroclinic energy conversion (denoted as CP) from the mean flow.The distribution of CK was dominated by its meridional component (CKy) in both modes.When integrated spatially,CKy was more efficient than its zonal component (CKx) in the first mode but less in the second mode.The distribution and efficiency of CK were not captured well by SAMIL2.0.However,the model performed reasonably well at reproducing the distribution and efficiency of CP in both modes.Because CP is more efficient than CK,the spatial patterns of the Silk Road pattern were well reproduced.Interestingly,the temporal phase of the second mode was well captured by a single-member simulation.However,further analysis of other ensemble runs demonstrated that the successful reproduction of the temporal phase was a result of internal variability rather than a signal of SST forcing.The analysis shows that the observed temporal variations of both CP and CK were poorly reproduced,leading to the low accuracy of the temporal phase of the Silk Road pattern in the simulation.

  5. Water Vapor and Cloud Radiative Forcings over the Pacific Ocean Simulated by the LASG/IAP AGCM: Sensitivity to Convection Schemes

    Institute of Scientific and Technical Information of China (English)

    WU Chunqiang; ZHOU Tianjun; SUN De-Zheng; BAO Qing

    2011-01-01

    Characteristics of the total clear-sky greenhouse effect (GA) and cloud radiative forcings (CRFs), along with the radiative-related water vapor and cloud properties simulated by the Spectral Atmospheric Model developed by LASG/IAP (SAMIL) are evaluated. Impacts of the convection scheme on the simulation of CRFs are discussed by using two AMIP (Atmospheric Model Inter-comparison Project) type simulations employing different convection schemes: the new Zhang-McFarlane (NZH) and Tiedtke (TDK) convection schemes. It shows that both the climatological GA and its response to El Nifio warming are simulated well, both in terms of spatial pattern and magnitude. The impact of the convection scheme on GA is not significant. The climatological longwav e CRF (LWCRF) and its response to El Nino warming are simulated well, but with a prominently weaker magnitude. The simulation of the climatology (response) of LWCRF in the NZH (TDK) run is slightly more realistic than in the TDK (NZH) simulation, indicating significant impacts of the convection scheme. The shortwave CRF (SWCRF) shows large biases in both spatial pattern and magnitude, and the results from the TDK run are better than those from the NZH run. A spuriously excessive negative climatological SWCRF over the southeastern Pacific and an insufficient response of SWCRF to El Nifio warming over the tropical Pacific are seen in the NZH run. These two biases are alleviated in the TDK run, since it produces vigorous convection, which is related to the low threshold for convection to take place. Also, impacts of the convection scheme on the cloud profile are discussed.

  6. Two modes of the silk road pattern and their interannual variability simulated by LASG/IAP AGCM SAMIL2.0

    Science.gov (United States)

    Song, Fengfei; Zhou, Tianjun; Wang, Lu

    2013-05-01

    In this study, two modes of the Silk Road pattern were investigated using NCEP2 reanalysis data and the simulation produced by Spectral Atmospheric Circulation Model of IAP LASG, Version 2 (SAMIL2.0) that was forced by SST observation data. The horizontal distribution of both modes were reasonably reproduced by the simulation, with a pattern correlation coefficient of 0.63 for the first mode and 0.62 for the second mode. The wave train was maintained by barotropic energy conversion (denoted as CK) and baroclinic energy conversion (denoted as CP) from the mean flow. The distribution of CK was dominated by its meridional component (CK y ) in both modes. When integrated spatially, CK y was more efficient than its zonal component (CK x ) in the first mode but less in the second mode. The distribution and efficiency of CK were not captured well by SAMIL2.0. However, the model performed reasonably well at reproducing the distribution and efficiency of CP in both modes. Because CP is more efficient than CK, the spatial patterns of the Silk Road pattern were well reproduced. Interestingly, the temporal phase of the second mode was well captured by a single-member simulation. However, further analysis of other ensemble runs demonstrated that the successful reproduction of the temporal phase was a result of internal variability rather than a signal of SST forcing. The analysis shows that the observed temporal variations of both CP and CK were poorly reproduced, leading to the low accuracy of the temporal phase of the Silk Road pattern in the simulation.

  7. Indian Academy of Pediatrics (IAP) recommended immunization schedule for children aged 0 through 18 years--India, 2014 and updates on immunization.

    Science.gov (United States)

    Vashishtha, Vipin M; Choudhury, Panna; Kalra, Ajay; Bose, Anuradha; Thacker, Naveen; Yewale, Vijay N; Bansal, C P; Mehta, Pravin J

    2014-10-01

    There is a need to review/revise recommendations about existing vaccines in light of recent developments in the field of vaccinology. Following an IAP ACVIP meeting on April 19 and 20, 2014, a draft of revised recommendations for the year 2014 and updates on certain vaccine formulations was prepared and circulated among the meeting participants to arrive at a consensus. To review and revise recommendations for 2014 Immunization timetable for pediatricians in office practice and issue statements on certain new and existing vaccine formulations. The major changes in the 2014 Immunization Timetable include two doses of MMR vaccine at 9 and 15 months of age, single dose recommendation for administration of live attenuated H2 strain hepatitis A vaccine, inclusion of two new situations in high-risk category of children in context with pre-exposure prophylaxis of rabies, creation of a new slot at 9-12 months of age for typhoid conjugate vaccine for primary immunization, and recommendation of two doses of human papilloma virus vaccines with a minimum interval of 6 months between doses for primary schedule of adolescent/preadolescent girls aged 9-14 years. There would not be any change to the committee's last year's (2013) recommendations on pertussis vaccination and administration schedule of monovalent human rotavirus vaccine. There is no need of providing additional doses of whole-cell pertussis vaccine to children who have earlier completed their primary schedule with acellular pertussis vaccine-containing products. A brief update on the new Indian Rotavirus vaccine, 116E is also provided. The committee has reviewed and offered its recommendations on the currently available pentavalent vaccine (DTwP+Hib+Hepatitis-B) combinations in Indian market. The comments and footnotes for several vaccines are also updated and revised.

  8. BONE PICTURE BOOK, A BOOK FOR STUDENTS USING THE ESS UNIT BONES.

    Science.gov (United States)

    Elementary Science Study, Newton, MA.

    THIS PICTURE BOOK WAS DEVELOPED FOR USE WITH THE ELEMENTARY SCIENCE STUDY UNIT ON "BONES." THE UNIT PROVIDES AN OPPORTUNITY TO DEVELOP MANY CONCEPTS ABOUT THE SKELETAL SYSTEM. NUMEROUS PHOTOGRAPHS ARE PROVIDED OF REPRESENTATIVES OF THE FIVE VERTEBRATE CLASSES AND SELECTED INVERTEBRATES. BOTH EXTANT AND EXTINCT MEMBERS ARE REPRESENTED. THE MEMBERS…

  9. Music as the Representative of the World Picture, the Phenomenon of Culture

    Science.gov (United States)

    Kossanova, Aigul Sh.; Yermanov, Zhanat R.; Bekenova, Aizhan S.; Julmukhamedova, Aizhan A.; Takezhanova, Roza Ph.; Zhussupova, Saule S.

    2016-01-01

    The purpose of this article is to the study of music as a representative of the picture of the world nomadic culture. With a systemic organization, rich expressive means, music reflects the diversity of the world in its complex, subtle and profound manifestations being the artistic value, key world modeling element. Music can satisfy the aesthetic…

  10. Video Data Link Provides Television Pictures In Near Real Time Via Tactical Radio And Satellite Channels

    Science.gov (United States)

    Hartman, Richard V.

    1987-02-01

    Advances in sophisticated algorithms and parallel VLSI processing have resulted in the capability for near real-time transmission of television pictures (optical and FLIR) via existing telephone lines, tactical radios, and military satellite channels. Concepts have been field demonstrated with production ready engineering development models using transform compression techniques. Preliminary design has been completed for packaging an existing command post version into a 20 pound 1/2 ATR enclosure for use on jeeps, backpacks, RPVs, helicopters, and reconnaissance aircraft. The system will also have a built-in error correction code 2 (ECC) unit, allowing operation via communicatons media exhibiting a bit error rate of 1 X 10-or better. In the past several years, two nearly simultaneous developments show promise of allowing the breakthrough needed to give the operational commander a practical means for obtaining pictorial information from the battlefield. And, he can obtain this information in near real time using available communications channels--his long sought after pictorial force multiplier: • High speed digital integrated circuitry that is affordable, and • An understanding of the practical applications of information theory. High speed digital integrated circuits allow an analog television picture to be nearly instantaneously converted to a digital serial bit stream so that it can be transmitted as rapidly or slowly as desired, depending on the available transmission channel bandwidth. Perhaps more importantly, digitizing the picture allows it to be stored and processed in a number of ways. Most typically, processing is performed to reduce the amount of data that must be transmitted, while still maintaining maximum picture quality. Reducing the amount of data that must be transmitted is important since it allows a narrower bandwidth in the scarce frequency spectrum to be used for transmission of pictures, or if only a narrow bandwidth is available, it

  11. How to Take a Picture of A Robotic Arm

    Science.gov (United States)

    2008-01-01

    [figure removed for brevity, see original site] Click on image for animation This movie first shows an artist's animation of NASA's Phoenix Mars Lander snapping a picture of its arm, then transitions to the actual picture of the arm in its stowed configuration, with its biobarrier unpeeled. The arm is still folded up, with its 'elbow' shown at upper left and its scoop at bottom right. The biobarrier is the shiny film seen to the left of the arm in this view. The barrier is an extra precaution to protect Mars from contamination with any bacteria from Earth. While the whole spacecraft was decontaminated through cleaning, filters and heat, the robotic arm was given additional protection because it is the only spacecraft part that will directly touch the ice below the surface of Mars. Before the arm was heated, it was sealed in the biobarrier, which is made of a trademarked film called Tedlar that holds up to baking like a turkey-basting bag. This ensures that any new bacterial spores that might have come about during the final steps before launch, and during the journey to Mars, will not contact the robotic arm. After Phoenix landed, springs were used to pop back the barrier, giving it room to deploy. The arm is scheduled to begin to unlatch on the third Martian day of the mission, or Sol 3 (May 28, 2008). This image was taken on Sol 1 (May 26, 2008) by the spacecraft's Surface Stereo Imager. The Phoenix Mission is led by the University of Arizona, Tucson, on behalf of NASA. Project management of the mission is by NASA's Jet Propulsion Laboratory, Pasadena, Calif. Spacecraft development is by Lockheed Martin Space Systems, Denver.

  12. Working through Children's Developmental and Existential Stress in Picture Books.

    Science.gov (United States)

    Schwarcz, Joseph H.

    The aesthetic quality and psychological subtlety of contemporary picture books give genuine expression to a child's conscious and unconscious thoughts and emotions. Increasingly, themes of existential and developmental stress are appearing in picture books. Typical reactions aroused by such stress factors--and also by themes treated in picture…

  13. Using Picture Books as Paired Texts to Teach Educational Theories

    Science.gov (United States)

    Gao, Yang; Bintz, William P.

    2015-01-01

    Picture books, when used thoughtfully and artfully, can teach theories to graduate students in literacy and foreign language education. In this article, the authors described how a pair of picture books is used to teach Vygotsky's "Zone of Proximal Development" and Krashen's "Input Hypothesis" in the fields of literacy…

  14. Early Understanding of the Representational Function of Pictures.

    Science.gov (United States)

    DeLoache, Judy S.; Burns, Nancy M.

    1994-01-01

    Twenty-four- and 30-month-old children were presented with a picture that showed the location of a hidden toy and were then asked to find the toy. The 30-month olds, but not the 24-month-olds, were successful in retrieving the toy. Concludes that 24-month olds did not interpret the pictures as representations of reality. (BC)

  15. The Picture of Reading: Deriving Meaning in Literacy through Image.

    Science.gov (United States)

    Piro, Joseph M.

    2002-01-01

    Presents speculations on broadening the concept of literacy and using pictures to teach. Discusses the importance and value of training students to "read" a painting and, by extension, a visual image and how this fits into promoting a culture of literacy. Considers the application of reader-response theory to pictures as text. (SG)

  16. Familiar Fairy Tale Picture Books Transformed into Teen Novels.

    Science.gov (United States)

    Chance, Rosemary

    2003-01-01

    Describes characteristics of fairy tales. Discusses use of fairy tales and novels for teens in the classroom. Presents annotations of 31 titles including both picture books and young adult novels grouped by nine popular tales. Concludes that through comparing picture books and teen novels, there is one last chance to introduce fairy tales to older…

  17. The Motion Picture and the Teaching of English.

    Science.gov (United States)

    Sheridan, Marion C.; And Others

    Written to help a viewer watch a motion picture perceptively, this book explains the characteristics of the film as an art form and examines the role of motion pictures in the English curriculum. Specific topics covered include (1) the technical aspects of the production of films (the order of "shots," camera angle, and point of view), (2) the…

  18. Creating Science Picture Books for an Authentic Audience

    Science.gov (United States)

    DeFauw, Danielle L.; Saad, Klodia

    2014-01-01

    This article presents an authentic writing opportunity to help ninth-grade students use the writing process in a science classroom to write and illustrate picture books for fourth-grade students to demonstrate and share their understanding of a biology unit on cells. By creating a picture book, students experience the writing process, understand…

  19. Child Readers and the Worlds of the Picture Book

    Science.gov (United States)

    Baird, Adela; Laugharne, Janet; Maagerø, Eva; Tønnessen, Elise Seip

    2016-01-01

    Children as readers of picture books and the ways they respond to, and make meaning from, such texts are the focus of this article, which reports on a small-scale study undertaken in Norway and Wales, UK. The theoretical framing of the research draws on concepts of the multimodal ensemble in picture books and of the reading event as part of a…

  20. Picture Book Exposure Elicits Positive Visual Preferences in Toddlers

    Science.gov (United States)

    Houston-Price, Carmel; Burton, Eliza; Hickinson, Rachel; Inett, Jade; Moore, Emma; Salmon, Katherine; Shiba, Paula

    2009-01-01

    Although the relationship between "mere exposure" and attitude enhancement is well established in the adult domain, there has been little similar work with children. This article examines whether toddlers' visual attention toward pictures of foods can be enhanced by repeated visual exposure to pictures of foods in a parent-administered picture…

  1. Radical Visions: Five Picture Books by Peter Sis.

    Science.gov (United States)

    Latham, Don

    2000-01-01

    Examines five picture books by author/illustrator Peter Sis, and how they deal explicitly with people who through extraordinary journeys develop extraordinary ways of seeing the world. Discusses use of paratextual elements, multiple formats, multiple layers of narrative, and a merging of texts and pictures. Suggests ways these books might be used…

  2. Effectiveness of Picture Books for Italian Instruction at Japanese Universities

    Science.gov (United States)

    Yomo, Minoru; Uni, Kazuhito; Moore, Danièle; Kiyose, Takashi

    2014-01-01

    Recently, the use of children's picture books to teach English has been increasing in Japan. An advantage of these books is the high proportion of basic vocabulary they include. Can picture books also be useful for teaching Japanese students Italian and increasing their motivation? The present study analyses the effectiveness of employing a…

  3. Reading pictures for story comprehension requires mental imagery skills

    NARCIS (Netherlands)

    Boerma, I.E.; Mol, S.E.; Jolles, J.

    2016-01-01

    We examined the role of mental imagery skills on story comprehension in 150 fifth graders (10- to 12-year-olds), when reading a narrative book chapter with alternating words and pictures (i.e., text blocks were alternated by one- or two-page picture spreads). A parallel group design was used, in whi

  4. Task choice and semantic interference in picture naming

    NARCIS (Netherlands)

    Piai, V.; Roelofs, A.P.A.; Schriefers, H.J.

    2015-01-01

    Evidence from dual-task performance indicates that speakers prefer not to select simultaneous responses in picture naming and another unrelated task, suggesting a response selection bottleneck in naming. In particular, when participants respond to tones with a manual response and name pictures with

  5. Task choice and semantic interference in picture naming

    NARCIS (Netherlands)

    Piai, V.; Roelofs, A.P.A.; Schriefers, H.J.

    2015-01-01

    Evidence from dual-task performance indicates that speakers prefer not to select simultaneous responses in picture naming and another unrelated task, suggesting a response selection bottleneck in naming. In particular, when participants respond to tones with a manual response and name pictures with

  6. Multilingual Children's Interaction with Metafiction in a Postmodern Picture Book

    Science.gov (United States)

    Daugaard, Line Møller; Johansen, Martin Blok

    2014-01-01

    When teachers and school librarians choose picture books for multilingual children, they often base their choice on an evaluation of linguistic comprehensibility, content familiarity and cultural appropriateness. This means that postmodern picture books may be excluded. This paper presents a case study of multilingual children's encounter with a…

  7. The Motion Picture in Science Education: "One Hundred Percent Efficiency."

    Science.gov (United States)

    King, Kenneth P.

    1999-01-01

    Provides an historical overview of the development of the motion picture as a tool within the context of science education. Examines the use of technology as a teaching tool in terms of scientific literacy and the means by which the motion picture helped to accomplish scientific literacy goals. (Author/CCM)

  8. The Motion Picture and the Teaching of English.

    Science.gov (United States)

    Sheridan, Marion C.; And Others

    Written to help a viewer watch a motion picture perceptively, this book explains the characteristics of the film as an art form and examines the role of motion pictures in the English curriculum. Specific topics covered include (1) the technical aspects of the production of films (the order of "shots," camera angle, and point of view), (2) the…

  9. Public Library Subject Headings for 16mm Motion Pictures. Revised.

    Science.gov (United States)

    California Library Association, Sacramento.

    Suggested subject headings for 16mm motion pictures are listed. The intent of the list is to provide audiovisual librarians with a tool which will aid them in making subject indexes for their printed catalogs. It is also intended as an authority for professional catalogers who may be called upon to catalog 16mm motion pictures. (Author/KKC)

  10. In Search of Bibliographic Control for Instructional Motion Picture Films.

    Science.gov (United States)

    Coover, Robert W.

    This historical study report describes phases in the development of applicable standards for cataloging instructional motion picture films. Steps leading to the present state of the art are objectively presented, focusing on standards developed to establish bibliographic control of instructional motion picture films, contemporary reaction to such…

  11. Holographic picture of heavy vector meson melting

    Energy Technology Data Exchange (ETDEWEB)

    Braga, Nelson R.F.; Diles, Saulo [Universidade Federal do Rio de Janeiro, Instituto de Fisica, Rio de Janeiro, RJ (Brazil); Martin Contreras, Miguel Angel [Universidad de los Andes, High Energy Group, Department of Physics, Bogota (Colombia)

    2016-11-15

    The fraction of heavy vector mesons produced in a heavy ion collision, as compared to a proton-proton collision, serves as an important indication of the formation of a thermal medium, the quark-gluon plasma. This sort of analysis strongly depends on understanding the thermal effects of a medium like the plasma on the states of heavy mesons. In particular, it is crucial to know the temperature ranges where they undergo a thermal dissociation, or melting. AdS/QCD models are know to provide an important tool for the calculation of hadronic masses, but in general are not consistent with the observation that decay constants of heavy vector mesons decrease with excitation level. It has recently been shown that this problem can be overcome using a soft wall background and introducing an extra energy parameter, through the calculation of correlation functions at a finite position of anti-de Sitter space. This approach leads to the evaluation of masses and decay constants of S wave quarkonium states with just one flavor dependent and one flavor independent parameter. Here we extend this more realistic model to finite temperatures and analyze the thermal behavior of the states 1S, 2S and 3S of bottomonium and charmonium. The corresponding spectral function exhibits a consistent picture for the melting of the states where, for each flavor, the higher excitations melt at lower temperatures. We estimate for these six states the energy ranges in which the heavy vector mesons undergo a transition from a well-defined peak in the spectral function to complete melting in the thermal medium. A very clear distinction between the heavy flavors emerges, with the bottomonium state Υ(1S) surviving a deconfinement transition at temperatures much larger than the critical deconfinement temperature of the medium. (orig.)

  12. Emotional sounds modulate early neural processing of emotional pictures

    Directory of Open Access Journals (Sweden)

    Antje B M Gerdes

    2013-10-01

    Full Text Available In our natural environment, emotional information is conveyed by converging visual and auditory information; multimodal integration is of utmost importance. In the laboratory, however, emotion researchers have mostly focused on the examination of unimodal stimuli. Few existing studies on multimodal emotion processing have focused on human communication such as the integration of facial and vocal expressions. Extending the concept of multimodality, the current study examines how the neural processing of emotional pictures is influenced by simultaneously presented sounds. Twenty pleasant, unpleasant, and neutral pictures of complex scenes were presented to 22 healthy participants. On the critical trials these pictures were paired with pleasant, unpleasant and neutral sounds. Sound presentation started 500 ms before picture onset and each stimulus presentation lasted for 2s. EEG was recorded from 64 channels and ERP analyses focused on the picture onset. In addition, valence, and arousal ratings were obtained. Previous findings for the neural processing of emotional pictures were replicated. Specifically, unpleasant compared to neutral pictures were associated with an increased parietal P200 and a more pronounced centroparietal late positive potential (LPP, independent of the accompanying sound valence. For audiovisual stimulation, increased parietal P100 and P200 were found in response to all pictures which were accompanied by unpleasant or pleasant sounds compared to pictures with neutral sounds. Most importantly, incongruent audiovisual pairs of unpleasant pictures and pleasant sounds enhanced parietal P100 and P200 compared to pairings with congruent sounds. Taken together, the present findings indicate that emotional sounds modulate early stages of visual processing and, therefore, provide an avenue by which multimodal experience may enhance perception.

  13. Aerial projection of three-dimensional motion pictures by electro-holography and parabolic mirrors.

    Science.gov (United States)

    Kakue, Takashi; Nishitsuji, Takashi; Kawashima, Tetsuya; Suzuki, Keisuke; Shimobaba, Tomoyoshi; Ito, Tomoyoshi

    2015-07-08

    We demonstrate an aerial projection system for reconstructing 3D motion pictures based on holography. The system consists of an optical source, a spatial light modulator corresponding to a display and two parabolic mirrors. The spatial light modulator displays holograms calculated by computer and can reconstruct holographic motion pictures near the surface of the modulator. The two parabolic mirrors can project floating 3D images of the motion pictures formed by the spatial light modulator without mechanical scanning or rotating. In this demonstration, we used a phase-modulation-type spatial light modulator. The number of pixels and the pixel pitch of the modulator were 1,080 × 1,920 and 8.0 μm × 8.0 μm, respectively. The diameter, the height and the focal length of each parabolic mirror were 288 mm, 55 mm and 100 mm, respectively. We succeeded in aerially projecting 3D motion pictures of size ~2.5 mm(3) by this system constructed by the modulator and mirrors. In addition, by applying a fast computational algorithm for holograms, we achieved hologram calculations at ~12 ms per hologram with 4 CPU cores.

  14. Picture Books Are for Little Kids, Aren't They? Using Picture Books with Adolescent Readers to Enhance Literacy Instruction

    Science.gov (United States)

    Senokossoff, Gwyn W.

    2013-01-01

    This article discusses the benefits of using picture books with adolescent readers, describes strategies that can be taught with picture books, and provides examples of books the author has used. Some of the topics discussed include: reading comprehension, visual literacy, interactive read-aloud with facilitative talk, literary elements, and…

  15. Picture Books Are for Little Kids, Aren't They? Using Picture Books with Adolescent Readers to Enhance Literacy Instruction

    Science.gov (United States)

    Senokossoff, Gwyn W.

    2013-01-01

    This article discusses the benefits of using picture books with adolescent readers, describes strategies that can be taught with picture books, and provides examples of books the author has used. Some of the topics discussed include: reading comprehension, visual literacy, interactive read-aloud with facilitative talk, literary elements, and…

  16. From emotion perception to emotion experience: emotions evoked by pictures and classical music.

    Science.gov (United States)

    Baumgartner, Thomas; Esslen, Michaela; Jäncke, Lutz

    2006-04-01

    Most previous neurophysiological studies evoked emotions by presenting visual stimuli. Models of the emotion circuits in the brain have for the most part ignored emotions arising from musical stimuli. To our knowledge, this is the first emotion brain study which examined the influence of visual and musical stimuli on brain processing. Highly arousing pictures of the International Affective Picture System and classical musical excerpts were chosen to evoke the three basic emotions of happiness, sadness and fear. The emotional stimuli modalities were presented for 70 s either alone or combined (congruent) in a counterbalanced and random order. Electroencephalogram (EEG) Alpha-Power-Density, which is inversely related to neural electrical activity, in 30 scalp electrodes from 24 right-handed healthy female subjects, was recorded. In addition, heart rate (HR), skin conductance responses (SCR), respiration, temperature and psychometrical ratings were collected. Results showed that the experienced quality of the presented emotions was most accurate in the combined conditions, intermediate in the picture conditions and lowest in the sound conditions. Furthermore, both the psychometrical ratings and the physiological involvement measurements (SCR, HR, Respiration) were significantly increased in the combined and sound conditions compared to the picture conditions. Finally, repeated measures ANOVA revealed the largest Alpha-Power-Density for the sound conditions, intermediate for the picture conditions, and lowest for the combined conditions, indicating the strongest activation in the combined conditions in a distributed emotion and arousal network comprising frontal, temporal, parietal and occipital neural structures. Summing up, these findings demonstrate that music can markedly enhance the emotional experience evoked by affective pictures.

  17. Inhibitor of Apoptosis (IAP) survivin is indispensable for survival of HER2 gene-amplified breast cancer cells with primary resistance to HER1/2-targeted therapies

    Energy Technology Data Exchange (ETDEWEB)

    Oliveras-Ferraros, Cristina; Vazquez-Martin, Alejandro; Cufi, Silvia; Torres-Garcia, Violeta Zenobia [Unit of Translational Research, Catalan Institute of Oncology-Girona, Avenida de Francia S/N, E-17007 Girona, Catalonia (Spain); Girona Biomedical Research Institute, Avenida de Francia S/N, E-17007 Girona, Catalonia (Spain); Sauri-Nadal, Tamara; Barco, Sonia Del [Girona Biomedical Research Institute, Avenida de Francia S/N, E-17007 Girona, Catalonia (Spain); Medical Oncology, Catalan Institute of Oncology-Girona, Avenida de Francia S/N, E-17007 Girona, Catalonia (Spain); Lopez-Bonet, Eugeni [Girona Biomedical Research Institute, Avenida de Francia S/N, E-17007 Girona, Catalonia (Spain); Department of Anatomical Pathology, Dr. Josep Trueta University Hospital, Avenida de Francia S/N, E-17007 Girona, Catalonia (Spain); Brunet, Joan [Girona Biomedical Research Institute, Avenida de Francia S/N, E-17007 Girona, Catalonia (Spain); Medical Oncology, Catalan Institute of Oncology-Girona, Avenida de Francia S/N, E-17007 Girona, Catalonia (Spain); Martin-Castillo, Begona [Girona Biomedical Research Institute, Avenida de Francia S/N, E-17007 Girona, Catalonia (Spain); Unit of Clinical Research, Catalan Institute of Oncology-Girona, Avenida de Francia S/N, E-17007 Girona, Catalonia (Spain); Menendez, Javier A., E-mail: jmenendez@idibgi.org [Unit of Translational Research, Catalan Institute of Oncology-Girona, Avenida de Francia S/N, E-17007 Girona, Catalonia (Spain); Girona Biomedical Research Institute, Avenida de Francia S/N, E-17007 Girona, Catalonia (Spain)

    2011-04-08

    Highlights: {yields} Intrinsic trastuzumab resistance occurs in {approx}70% of metastatic HER2 + breast carcinomas (BC). {yields} Approximately 15% of early HER2 + BC relapse in spite of treatment with trastuzumab-based therapies. {yields} HER2-independent downstream pro-survival pathways might underlie trastuzumab refractoriness. {yields} Survivin is indispensable for proliferation and survival of HER2 + BC unresponsive to HER2-targeted therapies ab initio. {yields} Survivin antagonists may clinically circumvent the occurrence of de novo resistance to HER2-directed drugs. -- Abstract: Primary resistance of HER2 gene-amplified breast carcinomas (BC) to HER-targeted therapies can be explained in terms of overactive HER2-independent downstream pro-survival pathways. We here confirm that constitutive overexpression of Inhibitor of Apoptosis (IAP) survivin is indispensable for survival of HER2-positive BC cells with intrinsic cross-resistance to multiple HER1/2 inhibitors. The IC{sub 50} values for the HER1/2 Tyrosine Kinase Inhibitors (TKIs) gefitinib, erlotinib and lapatinib were up to 40-fold higher in trastuzumab-unresponsive JIMT-1 cells than in trastuzumab-naive SKBR3 cells. ELISA-based and immunoblotting assays demonstrated that trastuzumab-refractory JIMT-1 cells constitutively expressed {approx}4 times more survivin protein than trastuzumab-responsive SKBR3 cells. In response to trastuzumab, JIMT-1 cells accumulated {approx}10 times more survivin than SKBR3 cells. HER1/2 TKIs failed to down-regulate survivin expression in JIMT-1 cells whereas equimolar doses of HER1/HER2 TKIs drastically depleted survivin protein in SKBR3 cells. ELISA-based detection of histone-associated DNA fragments confirmed that trastuzumab-refractory JIMT-1 cells were intrinsically protected against the apoptotic effects of HER1/2 TKIs. Of note, when we knocked-down survivin expression using siRNA and then added trastuzumab, cell proliferation and colony formation were completely

  18. Indian Academy of Pediatrics (IAP) recommended immunization schedule for children aged 0 through 18 years, India, 2013 and updates on immunization.

    Science.gov (United States)

    Vashishtha, Vipin M; Kalra, Ajay; Bose, Anuradha; Choudhury, Panna; Yewale, Vijay N; Bansal, C P; Gupta, Sailesh G

    2013-12-01

    There is a need to review/revise recommendations about existing vaccines in light of recent developments in the field of vaccinology where new developments are taking place regularly at short intervals. Following an IAP ACVIP meeting on 3rd and 4th August, 2013, a draft of revised recommendations for the year 2013 and updates on certain new vaccine formulations was prepared and circulated among the meeting participants to arrive at a consensus. To review and revise recommendations for 2013 Immunization timetable for pediatricians in office practice and issue statements on new vaccine formulations. The major change in the 2013 Immunization timetable was made in the recommendations pertaining to pertussis immunization. Taking in to the consideration of recent outbreaks of pertussis in many industrialized countries using acellular pertussis (aP) vaccines and subsequent finding of faster waning of the same in comparison to whole-cell pertussis (wP) vaccines and superior priming with wP vaccines than aP vaccines, the committee has now recommended wP vaccines for the primary series of infant vaccination. Guidelines are now also issued on the preference/selection of a particular aP vaccine in case it is not feasible to use wP vaccine, and use of Tdap vaccine during pregnancy. The administration schedule of monovalent human rotavirus vaccine, RV1 has been revised to 10 and 14 weeks from existing 6 and 10 weeks. Recommendation is made for the need of booster dose of live attenuated SA-14-14-2 JE vaccine. Updates and recommendations are issued on new typhoid conjugate vaccine, inactivated vero-cell culture derived SA-14-14-2 JE vaccine, inactivated vero-cell derived Kolar strain, 821564XY JE vaccine, and new meningococcal conjugate vaccines. This year the recommended immunization schedule with range for persons aged 0 through 18 years is being published together instead of two separate schedules. A subcategory of general instruction is added in footnotes. The comments and

  19. Picture Collage with Genetic Algorithm and Stereo vision

    Directory of Open Access Journals (Sweden)

    Hesam Ekhtiyar

    2011-09-01

    Full Text Available In this paper, a salient region extraction method for creating picture collage based on stereo vision is proposed. Picture collage is a kind of visual image summary to arrange all input images on a given canvas, allowing overlay, to maximize visible visual information. The salient regions of each image are firstly extracted and represented as a depth map. The output picture collage shows as many visible salient regions (without being overlaid by others from all images as possible. A very efficient Genetic algorithm is used here for the optimization. The experimental results showed the superior performance of the proposed method.

  20. Design and Realization of Mine Roadways Geological Sketch Picture Drawing System Based on ArcGIS Engine%基于ArcGIS Engine的煤矿巷道地质素描制图系统的设计与实现

    Institute of Scientific and Technical Information of China (English)

    苏成宝; 邹海

    2009-01-01

    目前煤矿地测部门在编制巷道地质素描时均采用手工制图的方式.这样存在着绘图速度慢,绘图精度不够,不便于修改和管理等缺点.因此采用人工检索、分析和处理地质测量信息资料已经难以满足煤矿现代化生产与技术管理的需要.本文采用ArcGIS Engine作为平台,实现了煤矿巷道地质素描的计算机自动成图,丰富了信息技术在煤矿地测应用领域的内容.本文阐述了系统的体系结构和系统的基本功能.%Manual mapping method is adopted by the mining geologic surveying department while compiling the drawings of mine geologic sketch picture. However, many disadvantages such as slow mapping speed, poor mapping precision, difficulty in modification and management are caused subsequently. So the old method using manual mapping and processing can not meet the need of modernization. A new system implementing automatic mapping based on ArcGIS Engine is proposed, and the main architecture and basic function of this system are introduced.

  1. Verifying Visual Properties in Sentence Verification Facilitates Picture Recognition Memory

    NARCIS (Netherlands)

    D. Pecher (Diane); K. Zanolie (Kiki); R. Zeelenberg (René)

    2007-01-01

    textabstractAccording to the perceptual symbols theory (Barsalou, 1999), sensorimotor simulations underlie the representation of concepts. We investigated whether recognition memory for pictures of concepts was facilitated by earlier representation of visual properties of those concepts. During stud

  2. Multilingual children's interaction with metafiction in a postmodern picture book

    DEFF Research Database (Denmark)

    Daugaard, Line Møller; Johansen, Martin Blok

    2014-01-01

    When teachers and school librarians choose picture books for multilingual children, they often base their choice on an evaluation of linguistic comprehensibility, content familiarity and cultural appropriateness. This means that postmodern picture books may be excluded. This paper presents a case...... study of multilingual children's encounter with a postmodern picture book with distinct metafictional features. In the page-by-page walkthroughs of the book, many of the multilingual children demonstrate a high level of literary competence. They deal with the book's metafictional features with great...... confidence and explicitly call for books which challenge them and break with their expectations as readers. Consequently, it is argued that postmodern picture books should be part of the range of books presented to multilingual children....

  3. Astronaut Robert Gibson prepares to use motion picture camera

    Science.gov (United States)

    1986-01-01

    Astronaut Robert L. Gibson, STS 61-C mission commander, partially floats on the aft flight deck of the Shuttle Columbia while preparing to use a motion picture camera. The windows overlooking the cargo bay are visible in the background.

  4. Directory of the Florida Motion Picture and Television Industry.

    Science.gov (United States)

    Florida State Dept. of Commerce, Tallahassee. Div. of Economic Development.

    Designed to assist the motion picture or television producer, this directory lists organizations (producers, distributors, talent agencies, laboratories, etc.) by geographical section in Florida. Each entry includes the company address, telephone, services available, a contact person, and credits. (DAG)

  5. THE EXPLORATION OF THE SELF IN PICTURES. PHOTO-THERAPY

    Directory of Open Access Journals (Sweden)

    ELENA NEDELCU

    2012-05-01

    Full Text Available We are living in a world surrounded by images; everywhere we go we are overwhelmed by commercials, plasma screens, posters etc. We get lost in these “perfect” pictures, we dream about that perfect body, that perfect sunny holiday and that perfectly happy family. We spend time consuming those pictures, but we don’t spend time to see ourselves as we are, to discover our inner self. But, can we discover ourselves in pictures? I believe so, but only when the pictures are created and not consumed. When pictures are created, creation becomes therapy and the result of the work becomes a means of self discovery and exploration. There are many examples of artists using different media like: sculpture, painting, installation, video that create pictures making use of their own body/face, of their own lives, of their own dreams, hallucinations or obsessions. This is a good way to bring their problems out of the subconscious, to use them in a creative and playful way, to visualize them and to share them with the world. The paper intends to explore the possibilities of self discovery through creating pictures, and in what proportion this activity can become therapy, art or both. The analysis will focus on the possibilities of accepting and comprehending oneself by taking pictures of oneself; on how genuine self-portraits can overcome the individual conflict between who one actually is, what one believes people’s perceptions of oneself are and who one thinks people want one to be in order to be accepted or even successful.

  6. The picture test of separation and individuation - preliminary research

    OpenAIRE

    Gregor Žvelc; Maša Žvelc

    2000-01-01

    Authors introduce a new instrument, which they developed for measuring separation and individuation process and attachment in adolescence and adulthood. The Picture Test of Separation and Individuation (PTSI) is a semi–projective test. It consists of various pictures, which represent relationships with significant others. PTSI is divided into three subtests: Relationship with Mother, Relationship with Father and Attachment. In a preliminary research on a sample of college and university...

  7. Stochastic Market Structure: Concentration Measures and Motion Picture Antitrust

    OpenAIRE

    De Vany, Arthur; Kim, Cassey Lee Hong

    2003-01-01

    This paper examines the usefulness of concentration indices in characterizing the degree of competition in the motion picture industry. It shows that concentration ratios and the Herfindahl-Hirschman index give a misleading picture of the degree of competition in the industry. All these indices exhibit large fluctuations that make the common practice of calculating a static measure erroneous. Market shares are shown to follow a stochastic Pareto- Lévy motion in which the market shares of the ...

  8. Teacher in Space trainees work with Arriflex motion picture camera

    Science.gov (United States)

    1985-01-01

    Teacher in Space trainees work with Arriflex motion picture camera. Photos include view of Sharon Christa McAuliffe (left) and Barbara Morgan having hands-on experience with an Arriflex motion picture camera following a briefing on space photography (40668); Morgan adjusts a lens as a studious McAuliffe looks on (40669); McAuliffe zeroes in on a test subject during a practice session with the Arriflex (40670); Morgan focuses on a subject (40671).

  9. Learning from picture books: Infants’ use of naming information

    Directory of Open Access Journals (Sweden)

    Melanie eKhu

    2014-02-01

    Full Text Available The present study investigated whether naming would facilitate infants’ transfer of information from picture books to the real world. Eighteen- and 21-month-olds learned a novel label for a novel object depicted in a picture book. Infants then saw a second picture book in which an adult demonstrated how to elicit the object’s nonobvious property. Accompanying narration described the pictures using the object’s newly learnt label. Infants were subsequently tested with the real-world object depicted in the book, as well as a different-colour exemplar. Infants’ performance on the test trials was compared with that of infants in a no label condition. When presented with the exact object depicted in the picture book, 21-month-olds were significantly more likely to elicit the object’s nonobvious property than were 18-month-olds. Learning the object’s label before learning about the object’s hidden property did not improve 18-month-olds’ performance. At 21-months, the number of infants in the label condition who attempted to elicit the real-world object’s nonobvious property was greater than would be predicted by chance, but the number of infants in the no label condition was not. Neither age group nor label condition predicted test performance for the different-colour exemplar. The findings are discussed in relation to infants’ learning and transfer from picture books.

  10. Reading Pictures for Story Comprehension Requires Mental Imagery Skills

    Directory of Open Access Journals (Sweden)

    Inouk E. Boerma

    2016-10-01

    Full Text Available We examined the role of mental imagery skills on story comprehension in 150 fifth graders (10-12-year-olds, when reading a narrative book chapter with alternating words and pictures (i.e., text blocks were alternated by one- or two-page picture spreads. A parallel group design was used, in which we compared our experimental book version, in which pictures were used to replace parts of the corresponding text, to two control versions, i.e., a text-only version and a version with the full story text and all pictures. Analyses showed an interaction between mental imagery and book version: children with higher mental imagery skills outperformed children with lower mental imagery skills on story comprehension after reading the experimental narrative. This was not the case for both control conditions. This suggests that children’s mental imagery skills significantly contributed to the mental representation of the story that they created, by successfully integrating information from both words and pictures. The results emphasize the importance of mental imagery skills for explaining individual variability in reading development. Implications for educational practice are that we should find effective ways to instruct children how to read pictures and how to develop and use their mental imagery skills. This will probably contribute to their mental models and therefore their story comprehension.

  11. Picture this! grasping the dimensions of time and space

    CERN Document Server

    Carroll, Michael

    2016-01-01

    Astronomical concepts can be truly hard to comprehend, especially those of planetary sizes and distances from Earth and from each other. These concepts are made more comprehensible by the group of illustrations in this book, which put, in scale, side by side extraterrestrial objects with objects on Earth we can more easily relate to. For example, study the pictures of Earth floating above Jupiter’s Great Red Spot and the asteroid Itokawa resting beside Toronto’s CN Tower. These mind-bending images bring things better into perspective and will help you understand the size and scale of our Solar System. In later chapters, you will be told how close the visionaries of the past came to guessing what today’s explorers would find. Astronomer/painter Lucien Rudaux’s masterpieces of Mars dust storms anticipated Viking and Mars rover images by nearly a century. Space artist Ludek Pesek envisioned astronauts setting up camp on the lunar surface in scenes hauntingly similar to photos taken by Apollo a...

  12. Computed radiographic image postprocessing in picture archiving and communication systems

    Science.gov (United States)

    Zhang, Jianguo; Andriole, Katherine P.; Huang, H. K.

    1997-05-01

    This paper presents the key post-processing algorithms for CR images used in our second generation PACS and its software implementation based on the algorithm features, fault tolerance and multilevel adaptive control, which can enable the benefits of image processing, good performance, speed and reliability.

  13. Social Attitudes toward Cerebral Palsy and Potential Uses in Medical Education Based on the Analysis of Motion Pictures

    Directory of Open Access Journals (Sweden)

    Marek Jóźwiak

    2015-01-01

    Full Text Available This study presents how motion pictures illustrate a person with cerebral palsy (CP, the social impact from the media, and the possibility of cerebral palsy education by using motion pictures. 937 motion pictures were reviewed in this study. With the criteria of nondocumentary movies, possibility of disability classification, and availability, the total number of motion pictures about CP was reduced to 34. The geographical distribution of movie number ever produced is as follows: North America 12, Europe 11, India 2, East Asia 6, and Australia 3. The CP incidences of different motor types in real world and in movies, respectively, are 78–86%, 65% (Spastic; 1.5–6%, 9% (Dyskinetic; 6.5–9%, 26% (Mixed; 3%, 0% (Ataxic; 3-4%, 0% (Hypotonic. The CP incidences of different Gross Motor Function Classification System (GMFCS levels in real world and in movies, respectively, are 40–51%, 47% (Level I + II; 14–19%, 12% (Level III; 34–41%, 41% (Level IV + V. Comparisons of incidence between the real world and the movies are surprisingly matching. Motion pictures honestly reflect the general public’s point of view to CP patients in our real world. With precise selection and medical professional explanations, motion pictures can play the suitable role making CP understood more clearly.

  14. Social Attitudes toward Cerebral Palsy and Potential Uses in Medical Education Based on the Analysis of Motion Pictures.

    Science.gov (United States)

    Jóźwiak, Marek; Chen, Brian Po-Jung; Musielak, Bartosz; Fabiszak, Jacek; Grzegorzewski, Andrzej

    2015-01-01

    This study presents how motion pictures illustrate a person with cerebral palsy (CP), the social impact from the media, and the possibility of cerebral palsy education by using motion pictures. 937 motion pictures were reviewed in this study. With the criteria of nondocumentary movies, possibility of disability classification, and availability, the total number of motion pictures about CP was reduced to 34. The geographical distribution of movie number ever produced is as follows: North America 12, Europe 11, India 2, East Asia 6, and Australia 3. The CP incidences of different motor types in real world and in movies, respectively, are 78-86%, 65% (Spastic); 1.5-6%, 9% (Dyskinetic); 6.5-9%, 26% (Mixed); 3%, 0% (Ataxic); 3-4%, 0% (Hypotonic). The CP incidences of different Gross Motor Function Classification System (GMFCS) levels in real world and in movies, respectively, are 40-51%, 47% (Level I + II); 14-19%, 12% (Level III); 34-41%, 41% (Level IV + V). Comparisons of incidence between the real world and the movies are surprisingly matching. Motion pictures honestly reflect the general public's point of view to CP patients in our real world. With precise selection and medical professional explanations, motion pictures can play the suitable role making CP understood more clearly.

  15. mPano: cloud-based mobile panorama view from single picture

    Science.gov (United States)

    Li, Hongzhi; Zhu, Wenwu

    2013-09-01

    Panorama view provides people an informative and natural user experience to represent the whole scene. The advances on mobile augmented reality, mobile-cloud computing, and mobile internet can enable panorama view on mobile phone with new functionalities, such as anytime anywhere query where a landmark picture is and what the whole scene looks like. To generate and explore panorama view on mobile devices faces significant challenges due to the limitations of computing capacity, battery life, and memory size of mobile phones, as well as the bandwidth of mobile Internet connection. To address the challenges, this paper presents a novel cloud-based mobile panorama view system that can generate and view panorama-view on mobile devices from a single picture, namely "Pano". In our system, first, we propose a novel iterative multi-modal image retrieval (IMIR) approach to get spatially adjacent images using both tag and content information from the single picture. Second, we propose a cloud-based parallel server synthing approach to generate panorama view in cloud, against today's local-client synthing approach that is almost impossible for mobile phones. Third, we propose predictive-cache solution to reduce latency of image delivery from cloud server to the mobile client. We have built a real mobile panorama view system and perform experiments. The experimental results demonstrated the effectiveness of our system and the proposed key component technologies, especially for landmark images.

  16. The Perception of Aversiveness of Surgical Procedure Pictures Is Modulated by Personal/Occupational Relevance.

    Science.gov (United States)

    Paes, Juliana; de Oliveira, Leticia; Pereira, Mirtes Garcia; David, Isabel; Souza, Gabriela Guerra Leal; Sobral, Ana Paula; Machado-Pinheiro, Walter; Mocaiber, Izabela

    2016-01-01

    It is well established that emotions are organized around two motivational systems: the defensive and the appetitive. Individual differences are relevant factors in emotional reactions, making them more flexible and less stereotyped. There is evidence that health professionals have lower emotional reactivity when viewing scenes of situations involving pain. The objective of this study was to investigate whether the rating of pictures of surgical procedure depends on their personal/occupational relevance. Fifty-two female Nursing (health discipline) and forty-eight Social Work (social science discipline) students participated in the experiment, which consisted of the presentation of 105 images of different categories (e.g., neutral, food), including 25 images of surgical procedure. Volunteers judged each picture according to its valence (pleasantness) and arousal using the Self-Assessment Manikin scale (dimensional approach). Additionally, the participants chose the word that best described what they felt while viewing each image (discrete emotion perspective). The average valence score for surgical procedure pictures for the Nursing group (M = 4.57; SD = 1.02) was higher than the score for the Social Work group (M = 3.31; SD = 1.05), indicating that Nursing students classified those images as less unpleasant than the Social Work students did. Additionally, the majority of Nursing students (65.4%) chose "neutral" as the word that best described what they felt while viewing the pictures. In the Social Work group, disgust (54.2%) was the emotion that was most frequently chosen. The evaluation of emotional stimuli differed according to the groups' personal/occupational relevance: Nursing students judged pictures of surgical procedure as less unpleasant than the Social Work students did, possibly reflecting an emotional regulation skill or some type of habituation that is critically relevant to their future professional work.

  17. Common Operating Picture: UAV Security Study

    Science.gov (United States)

    2004-01-01

    This initial communication security study is a top-level assessment of basic security issues related to the operation of Unmanned Aerial Vehicles (UAVs) in the National Airspace System (NAS). Security considerations will include information relating to the use of International Civil Aviation Organization (ICAO) Aeronautical Telecommunications Network (ATN) protocols and applications identifying their maturity, as well as the use of IPV4 and a version of mobile IPV6. The purpose of this assessment is to provide an initial analysis of the security implications of introducing UAVs into the NAS.

  18. Picture archiving and communication in radiology.

    Science.gov (United States)

    Napoli, Marzia; Nanni, Marinella; Cimarra, Stefania; Crisafulli, Letizia; Campioni, Paolo; Marano, Pasquale

    2003-01-01

    After over 80 years of exclusive archiving of radiologic films, at present, in Radiology, digital archiving is increasingly gaining ground. Digital archiving allows a considerable reduction in costs and space saving, but most importantly, immediate or remote consultation of all examinations and reports in the hospital clinical wards, is feasible. The RIS system, in this case, is the starting point of the process of electronic archiving which however is the task of PACS. The latter can be used as radiologic archive in accordance with the law provided that it is in conformance with some specifications as the use of optical long-term storage media or with electronic track of change. PACS archives, in a hierarchical system, all digital images produced by each diagnostic imaging modality. Images and patient data can be retrieved and used for consultation or remote consultation by the reporting radiologist who requires images and reports of previous radiologic examinations or by the referring physician of the ward. Modern PACS owing to the WEB server allow remote access to extremely simplified images and data however ensuring the due regulations and access protections. Since the PACS enables a simpler data communication within the hospital, security and patient privacy should be protected. A secure and reliable PACS should be able to minimize the risk of accidental data destruction, and should prevent non authorized access to the archive with adequate security measures in relation to the acquired knowledge and based on the technological advances. Archiving of data produced by modern digital imaging is a problem now present also in small Radiology services. The technology is able to readily solve problems which were extremely complex up to some years ago as the connection between equipment and archiving system owing also to the universalization of the DICOM 3.0 standard. The evolution of communication networks and the use of standard protocols as TCP/IP can minimize

  19. The Frog Inner Ear: Picture Perfect?

    OpenAIRE

    Mason, Matthew James; Segenhout, Johannes M.; Cobo-Cuan, Ariadna; Quiñones, Patricia M.; van Dijk, Pim

    2015-01-01

    This is the accepted manuscript of a paper published in the Journal of the Association for Research in Otolaryngology (2015) DOI: 10.1007/s10162-015-0506-z Many recent accounts of the frog peripheral auditory system have reproduced Wever’s (1973) schematic cross-section of the ear of a leopard frog. We sought to investigate to what extent this diagram is an accurate and representative depiction of the anuran inner ear, using three-dimensional reconstructions made from serial sections of Ra...

  20. Biomolecular simulation: historical picture and future perspectives.

    Science.gov (United States)

    van Gunsteren, Wilfred F; Dolenc, Jozica

    2008-02-01

    Over the last 30 years, computation based on molecular models is playing an increasingly important role in biology, biological chemistry and biophysics. Since only a very limited number of properties of biomolecular systems are actually accessible to measurement by experimental means, computer simulation complements experiments by providing not only averages, but also distributions and time series of any definable, observable or non-observable, quantity. Biomolecular simulation may be used (i) to interpret experimental data, (ii) to provoke new experiments, (iii) to replace experiments and (iv) to protect intellectual property. Progress over the last 30 years is sketched and perspectives are outlined for the future.