WorldWideScience

Sample records for pico amp beam currents

  1. Pico amp measurement circuit with high system isolation

    Energy Technology Data Exchange (ETDEWEB)

    Akins, J.H.

    1980-06-01

    An increase in sensitivity of 2000 can be achieved by modifying a Tektronics P6042 Hall Effect probe to accept 2000 turns as opposed to the standard single turn current input line. This increase in sensitivity coupled with a special self-zeroing amplifier allows the measurement of Pico-amps while maintaining high system isolation.

  2. The OpenPicoAmp : an open-source planar lipid bilayer amplifier for hands-on learning of neuroscience

    CERN Document Server

    Shlyonsky, Vadim; Gall, David

    2014-01-01

    Neuroscience education can be promoted by the availability of low cost and engaging teaching materials. To address this, we developed an open-source lipid bilayer amplifier, the OpenPicoAmp, which is appropriate for use in introductory courses in biophysics or neurosciences concerning the electrical properties of the cell membrane. The amplifier is designed using the common lithographic printed circuit board fabrication process and off-the-shelf electronic components. In addition, we propose a specific design for experimental chambers allowing the insertion of a commercially available polytetrafluoroethylene film. This experimental setup can be used in simple experiments in which students monitor the bilayer formation by capacitance measurement and record unitary currents produced by ionophores like gramicidin A. Used in combination with a low-cost data acquisition board this system provides a complete solution for hands-on lessons, therefore improving the effectiveness in teaching basic neurosciences or biop...

  3. The OpenPicoAmp: an open-source planar lipid bilayer amplifier for hands-on learning of neuroscience.

    Directory of Open Access Journals (Sweden)

    Vadim Shlyonsky

    Full Text Available Understanding the electrical biophysical properties of the cell membrane can be difficult for neuroscience students as it relies solely on lectures of theoretical models without practical hands on experiments. To address this issue, we developed an open-source lipid bilayer amplifier, the OpenPicoAmp, which is appropriate for use in introductory courses in biophysics or neurosciences at the undergraduate level, dealing with the electrical properties of the cell membrane. The amplifier is designed using the common lithographic printed circuit board fabrication process and off-the-shelf electronic components. In addition, we propose a specific design for experimental chambers allowing the insertion of a commercially available polytetrafluoroethylene film. We provide a complete documentation allowing to build the amplifier and the experimental chamber. The students hand-out giving step-by step instructions to perform a recording is also included. Our experimental setup can be used in basic experiments in which students monitor the bilayer formation by capacitance measurement and record unitary currents produced by ionic channels like gramicidin A dimers. Used in combination with a low-cost data acquisition board this system provides a complete solution for hands-on lessons, therefore improving the effectiveness in teaching basic neurosciences or biophysics.

  4. The OpenPicoAmp: an open-source planar lipid bilayer amplifier for hands-on learning of neuroscience.

    Science.gov (United States)

    Shlyonsky, Vadim; Dupuis, Freddy; Gall, David

    2014-01-01

    Understanding the electrical biophysical properties of the cell membrane can be difficult for neuroscience students as it relies solely on lectures of theoretical models without practical hands on experiments. To address this issue, we developed an open-source lipid bilayer amplifier, the OpenPicoAmp, which is appropriate for use in introductory courses in biophysics or neurosciences at the undergraduate level, dealing with the electrical properties of the cell membrane. The amplifier is designed using the common lithographic printed circuit board fabrication process and off-the-shelf electronic components. In addition, we propose a specific design for experimental chambers allowing the insertion of a commercially available polytetrafluoroethylene film. We provide a complete documentation allowing to build the amplifier and the experimental chamber. The students hand-out giving step-by step instructions to perform a recording is also included. Our experimental setup can be used in basic experiments in which students monitor the bilayer formation by capacitance measurement and record unitary currents produced by ionic channels like gramicidin A dimers. Used in combination with a low-cost data acquisition board this system provides a complete solution for hands-on lessons, therefore improving the effectiveness in teaching basic neurosciences or biophysics.

  5. Low current beam techniques

    Energy Technology Data Exchange (ETDEWEB)

    Saint, A.; Laird, J.S.; Bardos, R.A.; Legge, G.J.F. [Melbourne Univ., Parkville, VIC (Australia). School of Physics; Nishijima, T.; Sekiguchi, H. [Electrotechnical Laboratory, Tsukuba (Japan).

    1993-12-31

    Since the development of Scanning Transmission Microscopy (STIM) imaging in 1983 many low current beam techniques have been developed for the scanning (ion) microprobe. These include STIM tomography, Ion Beam Induced Current, Ion Beam Micromachining and Microlithography and Ionoluminense. Most of these techniques utilise beam currents of 10{sup -15} A down to single ions controlled by beam switching techniques This paper will discuss some of the low beam current techniques mentioned above, and indicate, some of their recent applications at MARC. A new STIM technique will be introduced that can be used to obtain Z-contrast with STIM resolution. 4 refs., 3 figs.

  6. CMOS technology and current-feedback op-amps

    DEFF Research Database (Denmark)

    Bruun, Erik

    1993-01-01

    Some of the problems related to the application of CMOS technology to current-feedback operational amplifiers (CFB op-amps) are identified. Problems caused by the low device transconductance and by the absence of matching between p-channel and n-channel transistors are examined, and circuit...... poor performance compared to the bipolar designs, but CMOS has a potential for CFB op-amp design if more ingenious circuit configurations are applied...

  7. Squid based beam current meter

    Energy Technology Data Exchange (ETDEWEB)

    Kuchnir, M.

    1983-11-25

    A SQUID based beam current meter has the capability of measuring the current of a beam with as little as 30 x 155 antiprotons (with a signal to noise ratio of 2). If low noise dc current is used to cancel most of the beam or an up-down counter is used to count auto-resets this sensitivity will be available at any time in the acumulation process. This current meter will therefore be a unique diagnostic tool for optimizing the performance of several Tev I components. Besides requiring liquid helium it seems that its only drawback is not to follow with the above sensitivity a sudden beam change larger than 16 ..mu..A, something that could be done using a second one in a less sensitive configuration.

  8. Matched-filtering generalized phase contrast using LCoS pico-projectors for beam-forming

    DEFF Research Database (Denmark)

    Bañas, Andrew Rafael; Palima, Darwin; Glückstad, Jesper

    2012-01-01

    We report on a new beam-forming system for generating high intensity programmable optical spikes using so-called matched-filtering Generalized Phase Contrast (mGPC) applying two consumer handheld pico-projectors. Such a system presents a low-cost alternative for optical trapping and manipulation......, optical lattices and other beam-shaping applications usually implemented with high-end spatial light modulators. Portable pico-projectors based on liquid crystal on silicon (LCoS) devices are used as binary phase-only spatial light modulators by carefully setting the appropriate polarization of the laser...... patterns suited for different requirements. Despite imperfections in these consumer pico-projectors, the mGPC approach tolerates phase aberrations that would have otherwise been hard to overcome by standard phase projection....

  9. LEDA beam diagnostics instrumentation: Beam current measurement

    Science.gov (United States)

    Barr, D.; Day, L.; Gilpatrick, J. D.; Kasemir, K.-U.; Martinez, D.; Power, J. F.; Shurter, R.; Stettler, M.

    2000-11-01

    The Low Energy Demonstration Accelerator (LEDA) facility located at Los Alamos National Laboratory (LANL) accelerates protons to an energy of 6.7 MeV and current of 100 mA operating in either a pulsed or cw mode. Two types of current measurements are used. The first is an AC or pulsed-current measurement which uses three LANL built toroids. They are placed in the beamline in such a way as to measure important transmission parameters and act as a differential current-loss machine protection system. The second system is a DC current measurement used to measure cw beam characteristics and uses toroids from Bergoz Inc. There are two of these systems, so they can also be used for transmission measurements. The AC system uses custom processing electronics whereas the DC system uses a modified Bergoz® electronics system. Both systems feature data acquisition via a series of custom TMS320C40 Digital Signal Processing (DSP) boards. Of special interest to this paper is the operation of these systems, the calibration technique, the differential current loss measurements and fast-protection processing, current droop characteristics for the AC system, and existing system noise levels. This paper will also cover the DSP system operations and their interaction with the main accelerator control system.

  10. Digitally compensated beam current transformer

    CERN Document Server

    Kesselman, Martin

    2005-01-01

    The Spallation Neutron Source (SNS) is being built by a collaboration of six laboratories. Beam current monitors (BCMs) will be used to record the current of H-minus and H-plus beams ranging from 15 mA (tune-up in the Front End and Linac) to over 60A fully accumulated in the Ring and dumped to the load as a single pulse in the Ring to Beam Target (RTBT). The time structure of these beams ranges from 645ns "mini" bunches at the 1.05 MHz ring revolution rate, to an overall 1 ms long macro-pulse. The requirements for the BCMs will depend upon their location within the system. The need to measure individual mini-pulses, examine the characteristics of the chopper edge, as well as the longer average current pulse of the macropulse, or long duration pulses during Linac tuning place wide requirements upon the response of current transformers. To obtain the desired accuracy and resolution, current transformers must have less than 1 ns rise time and droops of 0.1 %/ms. This places a significant design burden on the cur...

  11. Matched-filtering generalized phase contrast using LCoS pico-projectors for beam-forming.

    Science.gov (United States)

    Bañas, Andrew; Palima, Darwin; Glückstad, Jesper

    2012-04-23

    We report on a new beam-forming system for generating high intensity programmable optical spikes using so-called matched-filtering Generalized Phase Contrast (mGPC) applying two consumer handheld pico-projectors. Such a system presents a low-cost alternative for optical trapping and manipulation, optical lattices and other beam-shaping applications usually implemented with high-end spatial light modulators. Portable pico-projectors based on liquid crystal on silicon (LCoS) devices are used as binary phase-only spatial light modulators by carefully setting the appropriate polarization of the laser illumination. The devices are subsequently placed into the object and Fourier plane of a standard 4f-setup according to the mGPC spatial filtering configuration. Having a reconfigurable spatial phase filter, instead of a fixed and fabricated one, allows the beam shaper to adapt to different input phase patterns suited for different requirements. Despite imperfections in these consumer pico-projectors, the mGPC approach tolerates phase aberrations that would have otherwise been hard to overcome by standard phase projection.

  12. A high-speed CMOS current op amp for very low supply voltage operation

    DEFF Research Database (Denmark)

    Bruun, Erik

    1994-01-01

    A CMOS implementation of a high-gain current mode operational amplifier (op amp) with a single-ended input and a differential output is described. This configuration is the current mode counterpart of the traditional voltage mode op amp. In order to exploit the inherent potential for high speed......, low voltage operation normally associated with current mode analog signal processing, the op amp has been designed to operate off a supply voltage of 1.5 V, and the signal path has been confined to N-channel transistors. With this design, a gain of 94 dB and a gain-bandwidth product of 65 MHz has been...

  13. Compact multiple laser beam scanning module for high-resolution pico-projector applications using a fiber bundle combiner

    Science.gov (United States)

    Ide, Masafumi; Fukaya, Shinpei; Yoda, Kaoru; Suzuki, Masaya

    2014-02-01

    We present a novel multiple laser beam scanning projection module using compact red-green-blue (RGB) fiber pigtailed laser modules for use in a high resolution pico-projector display system using a fiber bundle combiner in combination with a single MEMS mirror. This system can be used to create accurate multiple-projection images on a screen without overlaps or spaces among the projection images. The system uses very simple projection optics and has the potential to become a light engine unit for use in multiple projection systems, particularly those for light field displays. As such, light field display applications are also discussed.

  14. Forskolin's effect on transient K current in nudibranch neurons is not reproduced by cAMP.

    Science.gov (United States)

    Coombs, J; Thompson, S

    1987-02-01

    Forskolin, a diterpene extracted from Coleus forskolii, stimulates the production of cAMP in a variety of cells and is potentially an important tool for studying the role of cAMP in the modulation of neuronal excitability. We studied the effects of forskolin on neurons of nudibranch molluscs and found that it caused characteristic, reversible changes in the amplitude and waveform of the transient K current, IA, and also activated an inward current similar to the cAMP-dependent inward current previously described in molluscan neurons. Forskolin altered the time course of IA activation and inactivation but did not affect the voltage dependence or the reversal potential of the current. IA normally inactivates exponentially, but in forskolin the time course of inactivation can be fit by the sum of 2 exponentials with an initial rate that is faster than the control and a final rate that is much slower. On depolarization in forskolin, IA begins to activate at the normal rate, but a slower component of activation is also seen. The changes in IA in the nudibranch cells were qualitatively different than the changes caused by forskolin in Aplysia bag cell neurons (Strong, 1984). Experiments were performed to determine whether these effects of forskolin require cAMP. Intracellular injection of cAMP, application of membrane-permeable analogs of cAMP, application of phosphodiesterase inhibitors, and intracellular injection of the active catalytic subunit of cAMP-dependent protein kinase did not affect the amplitude or waveform of IA. Also, the changes in IA that are caused by forskolin were not prevented or reversed by intracellular injection of an inhibitor of cAMP-dependent protein kinase. Cyclic AMP did, however, activate inward current at voltages near the resting potential. We conclude that the changes in IA and the activation of inward current represent separate affects of forskolin. The inward current appears to depend on an increase in intracellular cAMP, while the

  15. Effect of cAMP on short-circuit current in isolated human ciliary body

    Institute of Scientific and Technical Information of China (English)

    WU Ren-yi; MA Ning; HU Qian-qian

    2013-01-01

    Background Cyclic adenosine monophosphate (cAMP) could activate chloride channels in bovine ciliary body and trigger an increase in the ionic current (short-circuit current,Isc) across the ciliary processes in pigs.The purpose of this study was to investigate how cAMP modulates Isc in isolated human ciliary processes and the possible involvement of chloride transport across the tissue in cAMP-induced Isc change.Methods In an Ussing-type chamber system,the Isc changes induced by the cAMP analogue 8-bromo-cAMP and an adenylyl cyclase activator forskolin in isolated human ciliary processes were assessed.The involvement of Cl-component in the bath solution was investigated.The effect of Cl-channel (10 μmol/L niflumic acid and 1 mmol/L 4,4′-diisothiocyanostilbene-2,2′-disulfonic acid (DIDS)),K+ channel (10 mmol/L tetraethylammonium chloride (TEA)),or Na+ channel blockers (1 mmol/L amiloride) on 8-bromo-cAMP-induced Isc change was also studied.Results Dose-dependently,8-bromo-cAMP (10 nmol/L-30 μmol/L) or forskolin (10 nmol/L-3 μmol/L) increased Isc across the ciliary processes with an increase in negative potential difference on the non-pigmented epithelium (NPE) side of the tissue.Isc increase induced by 8-bromo-cAMP was more pronounced when the drug was applied on the NPE side than on the pigmented epithelium side.When the tissue was bathed in low Cl-solutions,the Isc increase was significantly inhibited.Finally,niflumic acid and DIDS,but not TEA or amiloride,significantly prevented the Isc increase induced by 8-bromo-cAMP.Conclusions cAMP stimulates stroma-to-aqueous anionic transport in isolated human ciliary processes.Chloride is likely to be among the ions,the transportation of which across the tissue is triggered by cAMP,suggesting the potential role of cAMP in the process of aqueous humor formation in human eyes.

  16. Sensitive beam current measurement for FAIR

    Energy Technology Data Exchange (ETDEWEB)

    Schwickert, Marcus; Kurian, Febin; Reeg, Hansjoerg [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Darmstadt (Germany); Seidel, Paul; Neubert, Ralf [Friedrich-Schiller-Universitaet Jena (Germany); Geithner, Rene; Vodel, Wolfgang [Helmholtz-Institut Jena (Germany)

    2012-07-01

    Presently FAIR, the Facility for Antiproton and Ion Research, entered the final planning phase at GSI. The new accelerator facility requires precise devices for beam current measurements due to the large dynamics in beam intensities for the various synchrotrons, transport lines and storage rings. We report on the actual developments of beam diagnostic devices for the measurement of beam intensities ranging from 5 x 10{sup 11} uranium ions down to the detection of less than 10{sup 4} antiprotons. This contribution gives an overview of the planned instruments with a focus on non-intercepting beam current transformers, and summarizes the on-going development of a cryogenic current comparator.

  17. A DSP-Based Beam Current Monitoring System for Machine Protection Using Adaptive Filtering

    Energy Technology Data Exchange (ETDEWEB)

    J. Musson; H. Dong; R. Flood; C. Hovater; J. Hereford

    2001-06-01

    The CEBAF accelerator at Jefferson Lab is currently using an analog beam current monitoring (BCM) system for its machine protection system (MPS), which has a loss accuracy of 2 micro-amps. Recent burn-through simulations predict catastrophic beam line component failures below 1 micro-amp of loss, resulting in a blind spot for the MPS. Revised MPS requirements target an ultimate beam loss accuracy of 250 nA. A new beam current monitoring system has been developed which utilizes modern digital receiver technology and digital signal processing concepts. The receiver employs a direct-digital down converter integrated circuit, mated with a Jefferson Lab digital signal processor VME card. Adaptive filtering is used to take advantage of current-dependent burn-through rates. Benefits of such a system include elimination of DC offsets, generic algorithm development, extensive filter options, and interfaces to UNIX-based control systems.

  18. Development of high current electron beam generator

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Byeong Cheol; Lee, Jong Min; Kim, Sun Kook [and others

    1997-05-01

    A high-current electron beam generator has been developed. The energy and the average current of the electron beam are 2 MeV and 50 mA, respectively. The electron beam generator is composed of an electron gun, RF acceleration cavities, a 260-kW RF generator, electron beam optics components, and control system, etc. The electron beam generator will be used for the development of a millimeter-wave free-electron laser and a high average power infrared free-electron laser. The machine will also be used as a user facility in nuclear industry, environment industry, semiconductor industry, chemical industry, etc. (author). 15 tabs., 85 figs.

  19. Cyclic AMP enhances calcium-dependent potassium current in Aplysia neurons.

    Science.gov (United States)

    Ewald, D; Eckert, R

    1983-12-01

    The effect on the Ca-dependent potassium current, IK(Ca), of procedures that increase intracellular cAMP levels was studied in Aplysia neurons using three different pharmacological approaches. Exposure to cAMP analogues which were either resistant to or protected from phosphodiesterase hydrolysis caused an increase in IK(Ca) from 30 to 50% in 10 min. The degree of reversibility of this effect varied from complete with db cAMP to very little with pcpt cAMP. Exposure to cholera toxin, which stimulates the synthesis of endogenous cAMP, increased IK(Ca) 25% in 10 min and the effect was not reversible. Both approaches were effective in all seven neuron types studied. Application of serotonin plus phosphodiesterase inhibitor caused an increase in IK(Ca) in neuron R15 but not in the other neuron types. Application of pentylene tetrazole (PTZ) led to a decrease in IK(Ca). It is proposed that elevation of cyclic AMP mediates an increased sensitivity of the IK(Ca) channel to Ca ions.

  20. Pico-ampere current sensitivity and CdSe quantum dots assembly assisted charge transport in ferroelectric liquid crystal

    Science.gov (United States)

    Pratap Singh, Dharmendra; Boussoualem, Yahia; Duponchel, Benoit; Sahraoui, Abdelhak Hadj; Kumar, Sandeep; Manohar, Rajiv; Daoudi, Abdelylah

    2017-08-01

    Octadecylamine capped CdSe quantum dots (QDs) dispersed 4-(1-methyl-heptyloxy)-benzoic acid 4‧-octyloxy-biphenyl-4-yl ester ferroelectric liquid crystal (FLC) were deposited over gold coated quartz substrate using dip-coating. The topographical investigation discloses that the homogeneously dispersed QDs adopt face-on to edge-on assembly in FLC matrix owing to their concentration. Current-voltage (I-V) measurement was performed using conductive atomic force microscopy (CAFM) which yields ohmic to critical diode like I-V curves depending upon the concentration of QDs in FLC. The recorded pico-ampere (pA) current sensitivity in FLC-QDs composites is attributed to micro-second drift time of electron due to weak electronic coupling between the π-electrons on the FLC and s-electrons on the metal surface. The observed pico-ampere sensitivity is the least current sensitivity recorded so far. For FLC-QDs composites, almost 24% faster electro-optic response was observed in comparison to pure FLC. The pico-ampere current sensitivity can be utilized in touch screen displays whereas the change in polarization for low applied electric field ameliorates the increased electrical susceptibility counteracting the internal electric field and its use in electronic data storage and faster electro-optical devices.

  1. Variable Current Transient Beam Loading Compensation

    Energy Technology Data Exchange (ETDEWEB)

    Farkas, Zoltan D

    2000-10-25

    The energy spread caused by transients during beam turn-on can be reduced by suitable timing of the beam turn-on[1]. If the beam is injected when the no-load voltage reaches the desired loaded voltage, then the energy spread is about 10%. To eliminate this energy spread, one can amplitude or phase modulate the section input power for one fill time, so that when the beam is turned on, the no-load voltage equals the desired loaded voltage and from then on, the change in no-load voltage tracks the beam induced voltage. It is known that for a constant gradient (CG) structure, and amplitude variation of the form E(t) = a{sub 0} + (1 - a{sub 0}) t{sub p} will reduce the energy spread to zero for a current that is determined by a{sub 0}. When one uses rf modulation for transient beam loading compensation, the beam is injected a fill time after the rf has been turned on, and one is forced to throw away a section's worth of rf energy. In addition, it requires extra components which use up additional rf energy. This note describes transient beam loading compensation with variable current. It will show that it increases the rf energy to beam energy transfer efficiency.

  2. Achromatic beam transport of High Current Injector

    Science.gov (United States)

    Kumar, Sarvesh; Mandal, A.

    2016-02-01

    The high current injector (HCI) provides intense ion beams of high charge state using a high temperature superconducting ECR ion source. The ion beam is accelerated upto a final energy of 1.8 MeV/u due to an electrostatic potential, a radio frequency quadrupole (RFQ) and a drift tube linac (DTL). The ion beam has to be transported to superconducting LINAC which is around 50 m away from DTL. This section is termed as high energy beam transport section (HEBT) and is used to match the beam both in transverse and longitudinal phase space to the entrance of LINAC. The HEBT section is made up of four 90 deg. achromatic bends and interconnecting magnetic quadrupole triplets. Two RF bunchers have been used for longitudinal phase matching to the LINAC. The ion optical design of HEBT section has been simulated using different beam dynamics codes like TRACEWIN, GICOSY and TRACE 3D. The field computation code OPERA 3D has been utilized for hardware design of all the magnets. All the dipole and quadrupole magnets have been field mapped and their test results such as edge angles measurements, homogeneity and harmonic analysis etc. are reported. The whole design of HEBT section has been performed such that the most of the beam optical components share same hardware design and there is ample space for beam diagnostics as per geometry of the building. Many combination of achromatic bends have been simulated to transport the beam in HEBT section but finally the four 90 deg. achromatic bend configuration is found to be the best satisfying all the geometrical constraints with simplified beam tuning process in real time.

  3. The LHC Fast Beam Current change Monitor

    CERN Document Server

    Belohrad, D; Jensen, L; Krupa, M; Topaloudis, A

    2013-01-01

    The modularity of the Large Hadron Collider’s (LHC) machine protection system (MPS) allows for the integration of several beam diagnostic instruments. These instruments have not necessarily been designed to have protection functionality, but MPS can still use them to increase the redundancy and reliability of the machine. The LHC fast beam current change monitor (FBCCM) is an example. It is based on analogue signals from fast beam current transformers (FBCT) used nominally to measure the LHC bunch intensities. The FBCCM calculates the magnitude of the beam signal provided by the FBCT, looks for a change over specific time intervals, and triggers a beam dump interlock if losses exceed an energy-dependent threshold. The first prototype of the FBCCM was installed in the LHC during the 2012-2013 run. The aim of this article is to present the FBCCM system and the results obtained, analyse its current performance and provide an outlook for the final system which is expected to be operational after the long LHC sh...

  4. Effects of AMP579 and adenosine on L-type Ca2+ current in isolated rat ventricular myocytes

    Institute of Scientific and Technical Information of China (English)

    Xiong WANG; Bo-wei WU; Dong-mei WU

    2005-01-01

    Aim: To compare the effects of AMP579 and adenosine on L-type Ca2+ current (ICa- L) in rat ventricular myocytes and explore the mechanism by which AMP579 acts on ICa-L. Methods: ICa-L was recorded by patch-clamp technique in whole-cell configuration. Results: Adenosine (10 nmol/L to 50 μmol/L) showed no effect on basal ICa- L, but it inhibited the ICa-L induced by isoproterenol 10 nmol/L in a concen tration-dependent manner with the IC50 of 13.06 μmol/L. Similar to adenosine,AMP579 also showed an inhibitory effect on the ICa-L induced by isoproterenol.AMP579 and adenosine (both in 10 μmol/L) suppressed isoproterenol-induced ICa-L by 11.1% and 5.2%, respectively. In addition, AMP579 had a direct inhibitory effect on basal ICa-L in a concentration-dependent manner with IC50 (1.17 μmol/L).PD116948 (30 μmol/L), an adenosine A1 receptor blocker, showed no action on the inhibitory effect of AMP579 on basal ICa-L. However, GF109203X (0.4 μmol/L), a special protein kinase C (PKC) blocker, could abolish the inhibitory effect of AMP579 on basal ICa-L. So the inhibitory effect of AMP579 on basal ICa-L was induced through activating PKC, but not linked to adenosine A1 receptor. Conclusion:AMP579 shows a stronger inhibitory effect than adenosine on the ICa-L induced by isoproterenol. AMP579 also has a strong inhibitory effect on basal ICa-L in rat ventricular myocytes. Activation of PKC is involved in the inhibitory effect of AMP579 on basal ICa-L at downstream-mechanism.

  5. Microstructure cantilever beam for current measurement

    Directory of Open Access Journals (Sweden)

    M.T.E. Khan

    2010-01-01

    Full Text Available Most microelectromechanical systems (MEMS sensors are based on the microcantilever technology, which uses a broad range of design materials and structures. The benefit ofMEMStechnology is in developing devices with a lower cost, lower power consumption, higher performance and greater integration. A free-end cantilever beam with a magnetic material mass has been designed using MEMS software tools. The magnetic material was used to improve the sensitivity of the cantilever beam to an externally-applied magnetic field. The cantilever was designed to form a capacitance transducer, which consisted of variable capacitance where electrical and mechanical energies were exchanged. The aim of this paper was to analyse the system design of the microcantilever when subjected to a magnetic field produced by a current-carrying conductor. When the signal, a sinusoidal current with a constant frequency, was applied, the cantilever beam exhibited a vibration motion along the vertical axis when placed closer to the line current. This motion created corresponding capacitance changes and generated a voltage output proportional to the capacitive change in the signal-processing circuitry attached to the microcantilever. The equivalent massspring system theory was used to describe and analyse the effect of the natural frequency of the system vibrations and motion due to the applied magnetic field, in a single-degree of freedom. The main application of this microcantilever is in current measurements to develop a non-contact current sensor mote.

  6. Current status of the LBNE neutrino beam

    CERN Document Server

    Moore, Craig Damon; Crowley, Cory Francis; Hurh, Patrick; Hylen, James; Lundberg, Byron; Marchionni, Alberto; McGee, Mike; Mokhov, Nikolai V; Papadimitriou, Vaia; Plunkett, Rob; Reitzner, Sarah Diane; Stefanik, Andrew M; Velev, Gueorgui; Williams, Karlton; Zwaska, Robert Miles

    2015-01-01

    The Long Baseline Neutrino Experiment (LBNE) will utilize a neutrino beamline facility located at Fermilab. The facility is designed to aim a beam of neutrinos toward a detector placed in South Dakota. The neutrinos are produced in a three-step process. First, protons from the Main Injector hit a solid target and produce mesons. Then, the charged mesons are focused by a set of focusing horns into the decay pipe, towards the far detector. Finally, the mesons that enter the decay pipe decay into neutrinos. The parameters of the facility were determined by an amalgam of the physics goals, the Monte Carlo modeling of the facility, and the experience gained by operating the NuMI facility at Fermilab. The initial beam power is expected to be ~700 kW, however some of the parameters were chosen to be able to deal with a beam power of 2.3 MW. The LBNE Neutrino Beam has made significant changes to the initial design through consideration of numerous Value Engineering proposals and the current design is described.

  7. NRSF causes cAMP-sensitive suppression of sodium current in cultured hippocampal neurons

    Science.gov (United States)

    Nadeau, H.; Lester, H. A.

    2002-01-01

    The neuron restrictive silencer factor (NRSF/REST) has been shown to bind to the promoters of many neuron-specific genes and is able to suppress transcription of Na(+) channels in PC12 cells, although its functional effect in terminally differentiated neurons is unknown. We constructed lentiviral vectors to express NRSF as a bicistronic message with green fluorescent protein (GFP) and followed infected hippocampal neurons in culture over a period of 1-2 wk. NRSF-expressing neurons showed a time-dependent suppression of Na(+) channel function as measured by whole cell electrophysiology. Suppression was reversed or prevented by the addition of membrane-permeable cAMP analogues and enhanced by cAMP antagonists but not affected by increasing protein expression with a viral enhancer. Secondary effects, including altered sensitivity to glutamate and GABA and reduced outward K(+) currents, were duplicated by culturing GFP-infected control neurons in TTX. The striking similarity of the phenotypes makes NRSF potentially useful as a genetic "silencer" and also suggests avenues of further exploration that may elucidate the transcription factor's in vivo role in neuronal plasticity.

  8. Persistent sodium current is a target for cAMP-induced neuronal plasticity in a state-setting modulatory interneuron.

    Science.gov (United States)

    Nikitin, E S; Kiss, T; Staras, K; O'shea, M; Benjamin, P R; Kemenes, G

    2006-01-01

    We have identified a TTX-resistant low-threshold persistent inward sodium current in the cerebral giant cells (CGCs) of Lymnaea, an important state-setting modulatory cell type of molluscan feeding networks. This current has slow voltage-dependent activation and de-activation kinetics, ultra-slow inactivation kinetics and fast de-inactivation kinetics. It activates at approximately -90 mV, peaks at approximately -30 mV, reverses at approximately +35 mV and does not show full voltage-dependent inactivation even at positive voltage steps. Lithium-sodium replacement experiments indicate that the persistent sodium current makes a significant contribution to the CGC membrane potential. Injection of cyclic adenosine monophosphate (cAMP) into the CGC cell body produces a large increase in the persistent sodium current that lasts for several hours. cAMP injection also leads to increased bursting, a significant decrease in the resistance and a significant depolarization of the soma membrane, indicating that cAMP-dependent mechanisms induce prolonged neuronal plasticity in the CGCs. Our observations provide the first link between cAMP-mediated modulation of a TTX-resistant persistent sodium current and prolonged neuronal plasticity in an identified modulatory cell type that plays an important role in behavioral state setting.

  9. LogAmp electronics and optical transmission for the new SPS beam position measurement system

    Science.gov (United States)

    Bogey, T.; Deplano, C.; Gonzalez, J. L.; Savioz, J. J.

    2013-12-01

    A new front-end board is under development for the CERN SPS Multi ORbit Position System (MOPOS). Based on logarithmic amplifiers, it measures the beam position over a large dynamic range of beam intensities and resolves the multi-batch structure of the SPS beams. Analogue data are digitized at 10 MS/s, packed in frames by an FPGA and on every turn sent to the readout board, via a 2.4 Gb/s optical transmission link. A first prototype has been successfully tested with several SPS beams. This paper presents an overall description of the system and its capabilities highlighted by the first beam measurements.

  10. LogAmp electronics and Optical Transmission for the new SPS Beam Position Measurement System

    CERN Document Server

    Deplano, C; Gonzalez, J L; Savioz, J J

    2013-01-01

    A new front-end board is under development for the CERN SPS Multi ORbit Position System (MOPOS). Based on logarithmic amplifiers, it measures the beam position over a large dynamic range of beam intensities and resolves the multi-batch structure of the SPS beams. Analogue data are digitized at 10 MS/s, packed in frames by an FPGA and on every turn sent to the readout board, via a 2.4 Gb/s optical transmission link. A first prototype has been successfully tested with several SPS beams. This paper presents an overall description of the system and its capabilities highlighted by the first beam measurements.

  11. The LANSCE Low Momentum Beam Monitor

    CERN Document Server

    Merl, R

    2004-01-01

    A diagnostic has been developed at the Los Alamos Neutron Science Center (LANSCE) for the purpose of identifying low momentum beam tails in the linear accelerator. These tails must be eliminated in order to maintain the transverse and longitudinal beam size. Instead of the currently used phosphor camera system, this instrument consists of a Multi Wire Proportional Chamber (MWPC) front end coupled to an EPICS compliant VME-based electronics package. Low momentum tails are detected with a resolution of 5 mm in the MWPC at a high dispersion point near a bending magnet. While phosphor is typically not sensitive in the nano amp range, the MWPC is sensitive down to about a pico amp. The electronics package processes the signals from each of the MWPC wires to generate an array of beam currents at each of the lower energies. The electronics has an analog front end with a high-speed analog to digital converter for each wire. Data from multiple wires are processed with an embedded digital signal processor and results p...

  12. High current precision long pulse electron beam position monitor

    CERN Document Server

    Nelson, S D; Fessenden, T J; Holmes, C

    2000-01-01

    Precision high current long pulse electron beam position monitoring has typically experienced problems with high Q sensors, sensors damped to the point of lack of precision, or sensors that interact substantially with any beam halo thus obscuring the desired signal. As part of the effort to develop a multi-axis electron beam transport system using transverse electromagnetic stripline kicker technology, it is necessary to precisely determine the position and extent of long high energy beams for accurate beam position control (6 - 40 MeV, 1 - 4 kA, 2 μs beam pulse, sub millimeter beam position accuracy.) The kicker positioning system utilizes shot-to-shot adjustments for reduction of relatively slow (< 20 MHz) motion of the beam centroid. The electron beams passing through the diagnostic systems have the potential for large halo effects that tend to corrupt position measurements.

  13. Beam brilliance investigation of high current ion beams at GSI heavy ion accelerator facility

    Energy Technology Data Exchange (ETDEWEB)

    Adonin, A. A., E-mail: a.adonin@gsi.de; Hollinger, R. [Linac and Operations/Ion Sources, GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt (Germany)

    2014-02-15

    In this work the emittance measurements of high current Ta-beam provided by VARIS (Vacuum Arc Ion Source) ion source are presented. Beam brilliance as a function of beam aperture at various extraction conditions is investigated. Influence of electrostatic ion beam compression in post acceleration gap on the beam quality is discussed. Use of different extraction systems (single aperture, 7 holes, and 13 holes) in order to achieve more peaked beam core is considered. The possible ways to increase the beam brilliance are discussed.

  14. Fast Beam Current Change Monitor for the LHC

    CERN Document Server

    Kral, Jan

    Stringent demands on the LHC safety and protection systems require improved methods of detecting fast beam losses. The Fast Beam Current Transformer (FBCT) is a measurement instrument, providing information about bunch-to-bunch intensity of the accelerated beam. This thesis describes the development of a new protection system based on the FBCT signal measurements. This system, the Fast Beam Current Change Monitor (FBCCM), measures the FBCT signal in a narrow frequency band and computes time derivation of the beam signal magnitude. This derivation is proportional to the beam losses. When the losses exceed a certain level, the FBCCM requests a beam dump in order to protect the LHC. The LHC protection will be ensured by four FBCCMs which will be installed into the LHC in July 2014. Six FBCCMs have been already constructed and their characteristics were measured with satisfactory results. The FBCCMs were tested by a laboratory simulation of the real LHC environment.

  15. Current status of HESYRL lithography beam line

    Science.gov (United States)

    Qian, Shinan; Li, Guihe; Liu, Zewen; Chen, Qianhong; Jiang, Dikui; kan, Ya; Liu, Wanpo

    1990-06-01

    A lithography beam line, as the first of possibly six or more, has been installed in the Hefei Synchrotron Radiation Laboratory (HESYRL). A scanning mirror is used to cut off shorter wavelengths and to expand exposure dimensions vertically. The scanning mirror is oscillated by a stepping motor while an in-situ Moirè fringe grating system measures motor speed uniformity. Some testing results are given. In the first part of the beam line, there is a beryllium window to block longer wavelength light, a laser alignment unit to align the beam line and a special exposure shutter, which is controlled by another stepping motor. An exposure chamber with vacuum of 5 × 10-7 torr is located 7 meters downstream from the source point. Because there is no window at the entrance of the chamber, a differential pumping system is needed. The chamber is equipped with a mask-wafer system, driven by a third stepping motor.

  16. Enhancing the accelerated beam current in the booster synchrotron by optimizing the transport line beam propagation

    Indian Academy of Sciences (India)

    Saini R S; Tyagi Y; Ghodke A D; Puntambekar T A

    2016-04-01

    In this paper, we present the results of transverse beam emittance and twiss parameter measurement of an electron beam, delivered by a 20 MeV microtron which is used as a pre-injector system for a booster synchrotron in the Indus Accelerator Facility at RRCAT Indore. Based on these measured beam parameters, beam optics of a transport line was optimized and its results are alsodiscussed in this paper. This beam transport line is used to transport the electron beam from the 20MeV microtron to the booster synchrotron. The booster synchrotron works as a main injector for Indus-1 and Indus-2 synchrotron radiation facilities. To optimize the beam optics of a transport linefor proper beam transmission through the line as well as to match the beam twiss parameters at the beam injection point of another accelerator, it is necessary to know the transverse beam emittance and twiss parameters of the beam coming from the first one. A MATLAB-based GUI program has been developed to calculate the beam emittance and twiss parameters, using quadrupole scanmethod. The measured parameters have been used for beam transport line optimization and twiss parameters matching at booster injection point. After this optimization, an enhancement of ∼50% beam current has been observed in the booster synchrotron.

  17. Low Starting Electron Beam Current in Degenerate Band Edge Oscillators

    CERN Document Server

    Othman, Mohamed A K; Figotin, Alexander; Capolino, Filippo

    2016-01-01

    We propose a new principle of operation in vacuum electron-beam-based oscillators that leads to a low beam current for starting oscillations. The principle is based on super synchronous operation of an electron beam interacting with four degenerate electromagnetic modes in a slow-wave structure (SWS). The four mode super synchronous regime is associated with a very special degeneracy condition in the dispersion diagram of a cold periodic SWS called degenerate band edge (DBE). This regime features a giant group delay in the finitelength SWS and low starting-oscillation beam current. The starting beam current is at least an order of magnitude smaller compared to a conventional backward wave oscillator (BWO) of the same length. As a representative example we consider a SWS conceived by a periodically-loaded metallic waveguide supporting a DBE, and investigate starting-oscillation conditions using Pierce theory generalized to coupled transmission lines (CTL). The proposed super synchronism regime can be straightf...

  18. Limiting current of intense electron beams in a decelerating gap

    Science.gov (United States)

    Nusinovich, G. S.; Beaudoin, B. L.; Thompson, C.; Karakkad, J. A.; Antonsen, T. M.

    2016-02-01

    For numerous applications, it is desirable to develop electron beam driven efficient sources of electromagnetic radiation that are capable of producing the required power at beam voltages as low as possible. This trend is limited by space charge effects that cause the reduction of electron kinetic energy and can lead to electron reflection. So far, this effect was analyzed for intense beams propagating in uniform metallic pipes. In the present study, the limiting currents of intense electron beams are analyzed for the case of beam propagation in the tubes with gaps. A general treatment is illustrated by an example evaluating the limiting current in a high-power, tunable 1-10 MHz inductive output tube (IOT), which is currently under development for ionospheric modification. Results of the analytical theory are compared to results of numerical simulations. The results obtained allow one to estimate the interaction efficiency of IOTs.

  19. Ion Beam Induced Surface Modulations from Nano to Pico: Optimizing Deposition During Erosion and Erosion During Deposition.

    Energy Technology Data Exchange (ETDEWEB)

    MoberlyChan, W J; Schalek, R

    2007-11-08

    Ion beams of sufficient energy to erode a surface can lead to surface modulations that depend on the ion beam, the material surface it impinges, and extrinsic parameters such as temperature and geometric boundary conditions. Focused Ion Beam technology both enables site-specific placement of these modulations and expedites research through fast, high dose and small efficient use of material. The DualBeam (FIB/SEM) enables in situ metrology, with movies observing ripple formation, wave motion, and the influence of line defects. Nanostructures (ripples of >400nm wavelength to dots spaced <40nm) naturally grow from atomically flat surfaces during erosion, however, a steady state size may or may not be achieved as a consequence of numerous controlled parameters: temperature, angle, energy, crystallography. Geometric factors, which can be easily invoked using a FIB, enable a controlled component of deposition (and/or redeposition) to occur during erosion, and conversely allow a component of etching to be incurred during (ion-beam assisted) deposition. High angles of ion beam inclination commonly lead to 'rougher' surfaces, however, the extreme case of 90.0{sup o} etching enables deposition of organized structures 1000 times smaller than the aforementioned, video-recorded nanostructures. Orientation and position of these picostructures (naturally quantized by their atomic spacings) may be controlled by the same parameters as for nanostructures (e.g. ion inclination and imposed boundary conditions, which are flexibly regulated by FIB). Judicious control of angles during FIB-CVD growth stimulates erosion with directionality that produces surface modulations akin to those observed for sputtering. Just as a diamond surface roughens from 1-D ripples to 2-D steps with increasing angle of ion sputtering, so do ripples and steps appear on carbon-grown surfaces with increase in angle of FIB-CVD. Ion beam processing has been a stalwart of the microelectronics industry

  20. Polymorphic beams and Nature inspired circuits for optical current

    Science.gov (United States)

    Rodrigo, José A.; Alieva, Tatiana

    2016-10-01

    Laser radiation pressure is a basis of numerous applications in science and technology such as atom cooling, particle manipulation, material processing, etc. This light force for the case of scalar beams is proportional to the intensity-weighted wavevector known as optical current. The ability to design the optical current according to the considered application brings new promising perspectives to exploit the radiation pressure. However, this is a challenging problem because it often requires confinement of the optical current within tight light curves (circuits) and adapting its local value for a particular task. Here, we present a formalism to handle this problem including its experimental demonstration. It consists of a Nature-inspired circuit shaping with independent control of the optical current provided by a new kind of beam referred to as polymorphic beam. This finding is highly relevant to diverse optical technologies and can be easily extended to electron and x-ray coherent beams.

  1. Effective shielding to measure beam current from an ion source

    Energy Technology Data Exchange (ETDEWEB)

    Bayle, H., E-mail: bayle@bergoz.com [Bergoz Instrumentation, Saint-Genis-Pouilly (France); Delferrière, O.; Gobin, R.; Harrault, F.; Marroncle, J.; Senée, F.; Simon, C.; Tuske, O. [CEA, Saclay (France)

    2014-02-15

    To avoid saturation, beam current transformers must be shielded from solenoid, quad, and RFQ high stray fields. Good understanding of field distribution, shielding materials, and techniques is required. Space availability imposes compact shields along the beam pipe. This paper describes compact effective concatenated magnetic shields for IFMIF-EVEDA LIPAc LEBT and MEBT and for FAIR Proton Linac injector. They protect the ACCT Current Transformers beyond 37 mT radial external fields. Measurements made at Saclay on the SILHI source are presented.

  2. High-current ion beam from a moving plasma

    Energy Technology Data Exchange (ETDEWEB)

    Dembinski, M.; John, P.K.; Ponomarenko, A.G.

    1979-05-01

    High-current ion beams in the 10--20-keV range are extracted from a moving plasma. Current densities up to 2.5 A/cm/sup 2/ are obtained at the plasma boundary, which is almost an order of magnitude larger than the Bohm current. Total currents of over 100 A are obtained from the plasma. Simple geometric focusing gives current densities approx.200 A/cm/sup 2/ at the focus.

  3. Range of Possible Beam Current in Linac4

    CERN Document Server

    Lallement, J-B; CERN. Geneva. BE Department

    2009-01-01

    Linac4 is a new accelerator under construction at CERN. It is designed to accelerate H- ions to 160MeV, for injection into the existing Proton Synchrotron Booster (PSB). It is also the front-end of the SPL Linac, a high energy proton driver that will reach the energy of 5GeV. The Linac baseline design has been done for a nominal beam peak current of 70mA but it will certainly have to deal with different currents. 132 out of 155 quadrupoles in the Linac are permanent magnets, this choice of using PMQ having fixed gradient, mainly in the DTL and in the CCDTL may then entail issues concerning the beam transverse matching and quality from current different from the nominal one. In this paper, we present the beam dynamics performances in Linac4 obtained for different currents.

  4. Image Currents in Azimuthally Inhomogeneous Metallic Beam Pipes

    CERN Document Server

    Caspers, Friedhelm; Palumbo, L; Ruggiero, F

    2001-01-01

    We consider an ultra-relativistic particle travelling on-axis in an infinitely long cylindrical metallic beam pipe with azimuthally varying conductivity. A semi-analytical solution, obtained by applying approximate boundary conditions, predicts an image current distribution on the pipe walls practically independent of the azimuth, at least in the frequency range relevant for future machines such as the LHC. We discuss numerical simulations and bench measurements which confirm the theoretical predictions. Implications for the beam-induced ohmic losses in the copper coated, welded LHC beam screen are also addressed.

  5. Image currents in azimuthally inhomogeneous metallic beam pipes

    Directory of Open Access Journals (Sweden)

    A. Mostacci

    2005-08-01

    Full Text Available We consider an ultrarelativistic particle traveling on axis in an infinitely long cylindrical metallic beam pipe with azimuthally varying conductivity. For a circular geometry, a semianalytical solution is obtained using the Green functions and applying approximate boundary conditions for conductors. The theory predicts an image current distribution on the pipe walls practically independent of the azimuth, at least in the frequency range relevant for future machines such as the LHC. Numerical electromagnetic simulations and bench measurements confirm the theoretical predictions. Implications for the beam-induced heating in the copper-coated, welded LHC beam screen are also addressed.

  6. Plasma Charge Current for Controlling and Monitoring Electron Beam Welding with Beam Oscillation

    Directory of Open Access Journals (Sweden)

    Valeriy Shchavlev

    2012-12-01

    Full Text Available Electron beam welding (EBW shows certain problems with the control of focus regime. The electron beam focus can be controlled in electron-beam welding based on the parameters of a secondary signal. In this case, the parameters like secondary emissions and focus coil current have extreme relationships. There are two values of focus coil current which provide equal value signal parameters. Therefore, adaptive systems of electron beam focus control use low-frequency scanning of focus, which substantially limits the operation speed of these systems and has a negative effect on weld joint quality. The purpose of this study is to develop a method for operational control of the electron beam focus during welding in the deep penetration mode. The method uses the plasma charge current signal as an additional informational parameter. This parameter allows identification of the electron beam focus regime in electron-beam welding without application of additional low-frequency scanning of focus. It can be used for working out operational electron beam control methods focusing exactly on the welding. In addition, use of this parameter allows one to observe the shape of the keyhole during the welding process.

  7. Plasma charge current for controlling and monitoring electron beam welding with beam oscillation.

    Science.gov (United States)

    Trushnikov, Dmitriy; Belenkiy, Vladimir; Shchavlev, Valeriy; Piskunov, Anatoliy; Abdullin, Aleksandr; Mladenov, Georgy

    2012-12-14

    Electron beam welding (EBW) shows certain problems with the control of focus regime. The electron beam focus can be controlled in electron-beam welding based on the parameters of a secondary signal. In this case, the parameters like secondary emissions and focus coil current have extreme relationships. There are two values of focus coil current which provide equal value signal parameters. Therefore, adaptive systems of electron beam focus control use low-frequency scanning of focus, which substantially limits the operation speed of these systems and has a negative effect on weld joint quality. The purpose of this study is to develop a method for operational control of the electron beam focus during welding in the deep penetration mode. The method uses the plasma charge current signal as an additional informational parameter. This parameter allows identification of the electron beam focus regime in electron-beam welding without application of additional low-frequency scanning of focus. It can be used for working out operational electron beam control methods focusing exactly on the welding. In addition, use of this parameter allows one to observe the shape of the keyhole during the welding process.

  8. Excitation of a cylindrical cavity by a helical current and an axial electron beam current

    Science.gov (United States)

    Davidovich, M. V.; Bushuev, N. A.

    2013-07-01

    The explicit expressions (in the Vainshtein and Markov forms) are derived for the excitation of a cylindrical cavity with perfectly conducting walls and with impedance end faces. Excitation of a cylindrical cavity and a cylindrical waveguide with a preset nonuniform axial electron-beam current and a helical current with a variable pitch, which is excited by a concentrated voltage source and is loaded by a preset pointlike matched load, is considered. For the helical current, the integro-differential equation is formulated. The traveling-wave tube (TWT) is simulated in the preset beam current approximation taking into account the nonuniform winding of the spiral coil, nonuniform electron beam, and losses.

  9. Regulated expression of HCN channels and cAMP levels shape the properties of the h current in developing rat hippocampus.

    Science.gov (United States)

    Surges, Rainer; Brewster, Amy L; Bender, Roland A; Beck, Heinz; Feuerstein, Thomas J; Baram, Tallie Z

    2006-07-01

    The hyperpolarization-activated current (I(h)) contributes to intrinsic properties and network responses of neurons. Its biophysical properties depend on the expression profiles of the underlying hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels and the presence of cyclic AMP (cAMP) that potently and differentially modulates I(h) conducted by HCN1, HCN2 and/or HCN4. Here, we studied the properties of I(h) in hippocampal CA1 pyramidal cells, the developmental evolution of the HCN-subunit isoforms that contribute to this current, and their interplay with age-dependent free cAMP concentrations, using electrophysiological, molecular and biochemical methods. I(h) amplitude increased progressively during the first four postnatal weeks, consistent with the observed overall increased expression of HCN channels. Activation kinetics of the current accelerated during this period, consonant with the quantitative reduction of mRNA and protein expression of the slow-kinetics HCN4 isoform and increased levels of HCN1. The sensitivity of I(h) to cAMP, and the contribution of the slow component to the overall I(h), decreased with age. These are likely a result of the developmentally regulated transition of the complement of HCN channel isoforms from cAMP sensitive to relatively cAMP insensitive. Thus, although hippocampal cAMP concentrations increased over twofold during the developmental period studied, the coordinated changes in expression of three HCN channel isoforms resulted in reduced effects of this signalling molecule on neuronal h currents.

  10. DPSS Laser Beam Quality Optimization Through Pump Current Tuning

    Energy Technology Data Exchange (ETDEWEB)

    Omohundro, Rob; /Newport Spectra-Physics, Santa Clara; Callen, Alice; /SLAC; Sukuta, Sydney; /San Jose City Coll.

    2012-03-30

    The goal of this study is to demonstrate how a DPSS laser beam's quality parameters can be simultaneously optimized through pump current tuning. Two DPSS lasers of the same make and model were used where the laser diode pump current was first varied to ascertain the lowest RMS noise region. The lowest noise was found to be 0.13% in this region and the best M{sup 2} value of 1.0 and highest laser output power were simultaneously attained at the same current point. The laser manufacturer reported a M{sup 2} value of 1.3 and RMS noise value of .14% for these lasers. This study therefore demonstrates that pump current tuning a DPSS laser can simultaneously optimize RMS Noise, Power and M{sup 2} values. Future studies will strive to broaden the scope of the beam quality parameters impacted by current tuning.

  11. Innovative real-time and non-destructive method of beam profile measurement under large beam current irradiation for BNCT

    Energy Technology Data Exchange (ETDEWEB)

    Takada, M., E-mail: m_takada@nirs.go.jp [National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan); Kamada, S.; Suda, M. [National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan); Fujii, R.; Nakamura, M. [Cancer Intelligence Care Systems, Inc., 3-5-7 Ariake, Koto-ku, Tokyo 135-0063 (Japan); Hoshi, M. [Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 kasumi, Minami-ku, Hiroshima 734-8553 (Japan); Sato, H. [Ibaraki Prefectural University of Health Sciences, 4669-2, Ami Ami-Cho, Inashiki-gun, Ibaraki 300-0394 (Japan); Endo, S. [Quantum Energy Applications, Graduate School of Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima 739-8527 (Japan); Hamano, T. [National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan); Arai, S.; Higashimata, A. [Sanki Industry Co., 318-6, Sannoh, Inage-ku, Chiba 263-0002 (Japan)

    2012-10-11

    We developed a real-time and non-destructive method of beam profile measurement on a target under large beam current irradiation, and without any complex radiation detectors or electrical circuits. We measured the beam profiles on a target by observing the target temperature using an infrared-radiation thermometer camera. The target temperatures were increased and decreased quickly by starting and stopping the beam irradiation within 1 s in response speed. Our method could trace beam movements rapidly. The beam size and position were calibrated by measuring O-ring heat on the target. Our method has the potential to measure beam profiles at beam current over 1 mA for proton and deuteron with the energy around 3 MeV and allows accelerator operators to adjust the beam location during beam irradiation experiments without decreasing the beam current.

  12. First test of BNL electron beam ion source with high current density electron beam

    Science.gov (United States)

    Pikin, Alexander; Alessi, James G.; Beebe, Edward N.; Shornikov, Andrey; Mertzig, Robert; Wenander, Fredrik; Scrivens, Richard

    2015-01-01

    A new electron gun with electrostatic compression has been installed at the Electron Beam Ion Source (EBIS) Test Stand at BNL. This is a collaborative effort by BNL and CERN teams with a common goal to study an EBIS with electron beam current up to 10 A, current density up to 10,000 A/cm2 and energy more than 50 keV. Intensive and pure beams of heavy highly charged ions with mass-to-charge ratio heavy ion research facilities including NASA Space Radiation Laboratory (NSRL) at BNL and HIE-ISOLDE at CERN. With a multiampere electron gun, the EBIS should be capable of delivering highly charged ions for both RHIC facility applications at BNL and for ISOLDE experiments at CERN. Details of the electron gun simulations and design, and the Test EBIS electrostatic and magnetostatic structures with the new electron gun are presented. The experimental results of the electron beam transmission are given.

  13. Optimization of solenoid based low energy beam transport line for high current H+ beams

    Science.gov (United States)

    Pande, R.; Singh, P.; Rao, S. V. L. S.; Roy, S.; Krishnagopal, S.

    2015-02-01

    A 20 MeV, 30 mA CW proton linac is being developed at BARC, Mumbai. This linac will consist of an ECR ion source followed by a Radio Frequency Quadrupole (RFQ) and Drift tube Linac (DTL). The low energy beam transport (LEBT) line is used to match the beam from the ion source to the RFQ with minimum beam loss and increase in emittance. The LEBT is also used to eliminate the unwanted ions like H2+ and H3+ from entering the RFQ. In addition, space charge compensation is required for transportation of such high beam currents. All this requires careful design and optimization. Detailed beam dynamics simulations have been done to optimize the design of the LEBT using the Particle-in-cell code TRACEWIN. We find that with careful optimization it is possible to transport a 30 mA CW proton beam through the LEBT with 100% transmission and minimal emittance blow up, while at the same time suppressing unwanted species H2+ and H3+ to less than 3.3% of the total beam current.

  14. Beam Current Measurement and Adjustment System on AMS

    Institute of Scientific and Technical Information of China (English)

    WUShao-yong; HEMING; SUSheng-yong; WANGZhen-jun; JIANGShan

    2003-01-01

    The beam current measurement and adjustment system of HI-13 tandem accelerator mass spectrometry detector system is consisted of the faraday cup, fluorescent target and a series of adjustable vertical slits(Fig. 1). The system's operation is very complicated and the transmission is low for the old system. A new system is instalated for improvement. We put the adjustable vertical slit, Faraday cup.

  15. High current density sheet-like electron beam generator

    Science.gov (United States)

    Chow-Miller, Cora; Korevaar, Eric; Schuster, John

    Sheet electron beams are very desirable for coupling to the evanescent waves in small millimeter wave slow-wave circuits to achieve higher powers. In particular, they are critical for operation of the free-electron-laser-like Orotron. The program was a systematic effort to establish a solid technology base for such a sheet-like electron emitter system that will facilitate the detailed studies of beam propagation stability. Specifically, the effort involved the design and test of a novel electron gun using Lanthanum hexaboride (LaB6) as the thermionic cathode material. Three sets of experiments were performed to measure beam propagation as a function of collector current, beam voltage, and heating power. The design demonstrated its reliability by delivering 386.5 hours of operation throughout the weeks of experimentation. In addition, the cathode survived two venting and pump down cycles without being poisoned or losing its emission characteristics. A current density of 10.7 A/sq cm. was measured while operating at 50 W of ohmic heating power. Preliminary results indicate that the nearby presence of a metal plate can stabilize the beam.

  16. PICO Bubble Chambers for Dark Matter Searches: Future Prospects

    Science.gov (United States)

    Neilson, Russell; PICO Collaboration

    2017-01-01

    The PICO collaboration uses bubble chambers to search for WIMP dark matter particles. The bubble chambers are operated in a moderately superheated state, providing superb rejection of the dominant gamma background, and are filled with fluorinated target fluids ideally suited for investigating spin-dependent WIMP-proton interactions. PICO currently operates a 2-liter (PICO-2L) and a 32-liter (PICO-60) bubble chamber at the SNOLAB deep underground laboratory. I will discuss recent activities by the PICO collaboration to understand and mitigate an anomalous background that has impacted previous dark matter searches, plans for the operating experiments, and prospects for a future ton-scale PICO bubble chamber.

  17. Grad-B drift transport of high current electron beams

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J.R.; Backstrom, R.C.; Halbleib, J.A.; Wright, T.P.

    1983-01-01

    Grad-B transport, bunching and focusing of relativistic electron beams has been proposed as a method of increasing the power delivered to an ICF target by an order of magnitude. Recent experiments have demonstrated the efficient transport of high current electron beams over 1.0 m distances in the 1/r azimuthal magnetic field of a current-carrying wire. The electron drift velocity was measured as a function of wire current and found to be in good agreement with theory. Measurements of x-ray production in a tantalum target were used as a diagnostic tool to study transport efficiency. A theoretical model of the experiment was developed to calculate bremsstrahlung production in the target, assuming 100 percent transport efficiency. This model predicted radial x-ray dose profiles in the experimental converter assembly which were in good agreement with the measurements.

  18. Current-Mode CMOS A/D Converter for Pico Ampere-Range with a Potentiostatic Input

    DEFF Research Database (Denmark)

    Breten, Madalina

    1999-01-01

    amount of a certain gas in a solution, such as oxygen in blood, can be determined by measuring the concentration-dependent current. The circuit that maintains the electrochemical stability in the sensor, as well as buffering the current output is called potentiostat.The DC current at the output....... In this context conversion techniques of the integration-type are preferred, such as dual-slope, multi-slope, or sigma-delta modulation. The performances of the comparator, clock-feedthrough effect, and the offset compensation are the main problems. Furthermore, if an analog circuit is designed as a building......-out. The influence and methods to reduce the nonlinearities of the A/D converter are discussed. At the input of the integrator was implemented a bridge of 4-switches in order to measure the low current with minimum charge injection, and to overcome the drift problems.A new conversion technique is proposed: folded-dual-slope...

  19. Gradient B drift transport of high current electron beams

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J.R.; Backstrom, R.C.; Halbleib, J.A.; Quintenz, J.P.; Wright, T.P.

    1984-12-01

    A 1-MeV, 200-kA electron beam was transported 89 cm in a low pressure background gas via gradient B drift in the 1/r azimuthal magnetic field of a current carrying wire. The electron drift velocity was measured and found to be in good agreement with theory. Measurements of x-ray production in the target indicated high transport efficiency.

  20. A CURRENT MIRROR BASED TWO STAGE CMOS CASCODE OP-AMP FOR HIGH FREQUENCY APPLICATION

    Directory of Open Access Journals (Sweden)

    RAMKRISHNA KUNDU

    2017-03-01

    Full Text Available This paper presents a low power, high slew rate, high gain, ultra wide band two stage CMOS cascode operational amplifier for radio frequency application. Current mirror based cascoding technique and pole zero cancelation technique is used to ameliorate the gain and enhance the unity gain bandwidth respectively, which is the novelty of the circuit. In cascading technique a common source transistor drive a common gate transistor. The cascoding is used to enhance the output resistance and hence improve the overall gain of the operational amplifier with less complexity and less power dissipation. To bias the common gate transistor, a current mirror is used in this paper. The proposed circuit is designed and simulated using Cadence analog and digital system design tools of 45 nanometer CMOS technology. The simulated results of the circuit show DC gain of 63.62 dB, unity gain bandwidth of 2.70 GHz, slew rate of 1816 V/µs, phase margin of 59.53º, power supply of the proposed operational amplifier is 1.4 V (rail-to-rail ±700 mV, and power consumption is 0.71 mW. This circuit specification has encountered the requirements of radio frequency application.

  1. A microbeam slit system for high beam currents

    Science.gov (United States)

    Vallentin, T.; Moser, M.; Eschbaumer, S.; Greubel, C.; Haase, T.; Reichart, P.; Rösch, T.; Dollinger, G.

    2015-04-01

    A new microbeam slit system for high beam currents of 10 μA was built up to improve the brightness transport of a proton beam with a kinetic energy of up to 25 MeV into the microprobe SNAKE. The new slit system features a position accuracy of less than 1 μm under normal operating conditions and less than 2 μm if the beam is switched on and off. The thermal management with a powerful watercooling and potential-free thermocouple feedback controlled heating cables is optimized for constant slit aperture at thermal power input of up to 250 W. The transparent zone is optimized to 0.7 μm due to the use of tungsten formed to a cylindrical surface with a radius r = 100 mm and mechanically lapped surface to minimize small angle scattering effects and to minimize the number of ions passing the slits with low energy loss. Electrical isolation of the slit tip enables slit current monitoring, e.g. for tandem accelerator feedback control. With the ability to transport up to 10 μA of protons with the new microslit system, the brightness Bexp transported into the microprobe was increased by a factor of 2 compared to low current injection using the old slit system.

  2. Dark matter searches with PICO bubble chambers: An overview

    Science.gov (United States)

    Harris, Orin; PICO Collaboration

    2017-01-01

    The PICO collaboration uses bubble chambers to search for dark matter, with world-leading sensitivity to the direct-detection of WIMPs with spin-dependent couplings to protons. PICO currently operates a 2 liter (PICO-2L) and a 32 liter (PICO 60) bubble chamber at the SNOLAB deep underground laboratory, and is currently constructing a 40 liter demonstration device that is expected to eliminate an anomalous background that has previously proven significant for the scaling of the bubble chamber technique to a future ton-scale experiment (PICO-500). A discussion of the technology, recent progress, and future plans will be presented.

  3. Current Measurements of Low-Intensity Beams at CRYRING

    CERN Document Server

    Paál, A; Källberg, A

    2003-01-01

    The demand for new ion species leads to an increasing number of cases in which the ions can only be produced in small quantities. Thus, weak ion currents quite often have to be handled in low energy ion storage ring, like CRYRING. Various detector systems have been developed to measure such low intensity coasting and bunched beams by using the overlapping ranges of those systems. We have extended the RMS resolution to 1 nA of the Bergoz Beam Charge Monitor (BCM) by using a low noise 60 dB preamplifier for the Integrating Current Transformer. The sum signal of a capacitive pick-up is integrated by a second gated integrator and the BCM output signal is used for calibration. The RMS resolution is about 100 pA.. To measure the coasting beam intensity, neutral particle detectors have been built. The fast Microchannel plate detector can handle 1 Mc/s, and a 50 Mc/s Secondary Electron Multiplier based detector is under construction. On the magnetic flat top, a time of 100 ms is available to calibrate the count r...

  4. Beam current transformer (BCT) for experiment WA1/2

    CERN Multimedia

    CERN PhotoLab

    1978-01-01

    In experiment WA1/2, a 400 GeV proton beam from the SPS was directed at a target, downstream of which a hadron line selected, in several narrow momentum bands, a beam of either pi+ and K+ or pi- and K-. These neutrino-parent particles, before entering a 292 m long decay tunnel, passed through a set of 2 BCTs of a design seen here. They measured the hadron intensity (10^10 to 10^11 particles/pulse) with a precision of the order of 1%. There were 2 of them, for enhanced precision and confidence. After the discovery of neutral currents in the Gargamelle-experiment, WA1/2 was the first follow-up, high-precision experiment (Z.Phys.C35, 443-452, 1987 and Z.Phys.C45, 361-379, 1990). See also 7706516X.

  5. Measurement of Ampère-class pulsed electron beams via field emission from carbon-nanotube cathodes in a radiofrequency gun

    Science.gov (United States)

    Mihalcea, D.; Faillace, L.; Hartzell, J.; Panuganti, H.; Boucher, S.; Murokh, A.; Piot, P.; Thangaraj, J. C. T.

    2015-07-01

    Pulsed field emission from cold carbon-nanotube cathodes placed in a radiofrequency resonant cavity was directly measured. The cathodes were located on the backplate of a conventional 1 + /1 2 -cell resonant cavity operating at 1.3-GHz and resulted in the production of bunch train with maximum average current close to 0.7 Ampère. The measured Fowler-Nordheim characteristic, transverse emittance, and pulse duration are presented and, when possible, compared to numerical simulations. The implications of our results to the promise of high-average-current electron sources are briefly discussed.

  6. First test of BNL electron beam ion source with high current density electron beam

    Energy Technology Data Exchange (ETDEWEB)

    Pikin, Alexander, E-mail: pikin@bnl.gov; Alessi, James G., E-mail: pikin@bnl.gov; Beebe, Edward N., E-mail: pikin@bnl.gov [Brookhaven National Laboratory, Upton, NY 11973 (United States); Shornikov, Andrey; Mertzig, Robert; Wenander, Fredrik; Scrivens, Richard [CERN, CH-1211 Geneva 23 (Switzerland)

    2015-01-09

    A new electron gun with electrostatic compression has been installed at the Electron Beam Ion Source (EBIS) Test Stand at BNL. This is a collaborative effort by BNL and CERN teams with a common goal to study an EBIS with electron beam current up to 10 A, current density up to 10,000 A/cm{sup 2} and energy more than 50 keV. Intensive and pure beams of heavy highly charged ions with mass-to-charge ratio < 4.5 are requested by many heavy ion research facilities including NASA Space Radiation Laboratory (NSRL) at BNL and HIE-ISOLDE at CERN. With a multiampere electron gun, the EBIS should be capable of delivering highly charged ions for both RHIC facility applications at BNL and for ISOLDE experiments at CERN. Details of the electron gun simulations and design, and the Test EBIS electrostatic and magnetostatic structures with the new electron gun are presented. The experimental results of the electron beam transmission are given.

  7. Development of beam current control system in RF-knockout slow extraction

    Science.gov (United States)

    Mizushima, K.; Sato, S.; Shirai, T.; Furukawa, T.; Katagiri, K.; Takeshita, E.; Iwata, Y.; Himukai, T.; Noda, K.

    2011-12-01

    A raster scanning method has been developed for cancer therapy at NIRS-HIMAC. This method requires a high-accuracy beam current control and fast beam-on/off switching. We have developed a feedback control system of the beam current with the RF-knockout slow extraction method. The system has allowed a stable response to beam-on/off switching using a feedback control delay function with a beam-current ripple of 7%.

  8. Development of beam current control system in RF-knockout slow extraction

    Energy Technology Data Exchange (ETDEWEB)

    Mizushima, K., E-mail: mizshima@nirs.go.jp [Department of Accelerator and Medical Physics, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan); Graduate School of Science and Technology, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522 (Japan); Sato, S.; Shirai, T.; Furukawa, T.; Katagiri, K.; Takeshita, E.; Iwata, Y.; Himukai, T.; Noda, K. [Department of Accelerator and Medical Physics, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan)

    2011-12-15

    A raster scanning method has been developed for cancer therapy at NIRS-HIMAC. This method requires a high-accuracy beam current control and fast beam-on/off switching. We have developed a feedback control system of the beam current with the RF-knockout slow extraction method. The system has allowed a stable response to beam-on/off switching using a feedback control delay function with a beam-current ripple of 7%.

  9. Design beam shapers with double freeform surfaces to form a desired wavefront with prescribed illumination pattern by solving a Monge-Ampère type equation

    Science.gov (United States)

    Chang, Shengqian; Wu, Rengmao; An, Li; Zheng, Zhenrong

    2016-12-01

    Beam shaping, in other words, the control of both intensity distribution and phase profile, has a wide range of applications. In this paper, double freeform surfaces are utilized to shape collimated beams, realizing an arbitrary output wavefront with desired illumination pattern. Freeform surfaces are designed by solving a second order partial differential equation (PDE) of the Monge-Ampère (MA) type, without the limitation of symmetry or paraxial approximation. The mathematical derivation of the PDE is based on the Snell’s law, the energy conservation law along infinitesimal tubes of rays and the constancy of the OPL. The PDE is discretized with a finite difference scheme into a system of nonlinear equations, which can be numerically solved by Newton’s method. Since Newton’s method requires a good initialization for the iteration, a simultaneously point-by-point method, based on ray mapping, is employed to find the initial iterate. Different design examples are given to demonstrate the effectiveness and wide application of our method, transforming a collimated Gaussian beam into a spherical wavefront with uniform illumination patterns. Variable-sized uniform illumination pattern can be obtained by moving the observation plane due to a potential benefit of the spherical output wavefront.

  10. High-energy tritium beams as current drivers in tokamak reactors

    Energy Technology Data Exchange (ETDEWEB)

    Mikkelsen, D.R.; Grisham, L.R.

    1983-04-01

    The effect on neutral-beam design and reactor performance of using high-energy (approx. 3-10 MeV) tritium neutral beams to drive steady-state tokamak reactors is considered. The lower current of such beams leads to several advantages over lower-energy neutral beams. The major disadvantage is the reduction of the reactor output caused by the lower current-drive efficiency of the high-energy beams.

  11. Computing High Accuracy Power Spectra with Pico

    CERN Document Server

    Fendt, William A

    2007-01-01

    This paper presents the second release of Pico (Parameters for the Impatient COsmologist). Pico is a general purpose machine learning code which we have applied to computing the CMB power spectra and the WMAP likelihood. For this release, we have made improvements to the algorithm as well as the data sets used to train Pico, leading to a significant improvement in accuracy. For the 9 parameter nonflat case presented here Pico can on average compute the TT, TE and EE spectra to better than 1% of cosmic standard deviation for nearly all $\\ell$ values over a large region of parameter space. Performing a cosmological parameter analysis of current CMB and large scale structure data, we show that these power spectra give very accurate 1 and 2 dimensional parameter posteriors. We have extended Pico to allow computation of the tensor power spectrum and the matter transfer function. Pico runs about 1500 times faster than CAMB at the default accuracy and about 250,000 times faster at high accuracy. Training Pico can be...

  12. Vertical blow-up in a low-current, stored, laser-cooled ion beam

    CERN Document Server

    Madsen, N; Siegfried, L E; Hangst, J S; Nielsen, J

    2003-01-01

    Using a novel technique for real-time transverse beam profile diagnostics of a stored ion beam, we have observed the transverse size of a stored, laser-cooled ion beam. Earlier we observed that the density of the beam is independent of the beam current. At very low currents we observe an abrupt change in this behavior: the vertical beam size increases suddenly by about an order of magnitude. This observation implies a sudden change in the indirect vertical cooling mediated by intrabeam scattering. Our results have serious implications for the ultimate beam quality attainable by laser- cooling. (12 refs).

  13. Effect of finite beam width on current separation in beam plasma system: Particle-in-Cell simulations

    CERN Document Server

    Shukla, Chandrasekhar; Patel, Kartik

    2015-01-01

    The electron beam propagation in a plasma medium is susceptible to several instabilities. In the relativistic regime typically the weibel instability leading to the current separation dominates. The linear instability analysis is carried out for a system wherein the transverse extent of the beam is infinite. Even in simulations, infinite transverse extent of the beam has been chosen. In real situations, however, beam width will always be finite. keeping this in view the role of finite beam width on the evolution of the beam plasma system has been studied here using Particle - in - Cell simulations. It is observed that the current separation between the forward and return shielding current for a beam with finite beam occurs at the scale length of the beam width itself. Consequently the magnetic field structures that form have maximum power at the scale length of the beam width. This behaviour is distinct from what happens with a beam with having an infinite extent represented by simulations in a periodic box, ...

  14. Giovanni Pico della Mirandola

    OpenAIRE

    Knudsen, Jesper; Kot, Rasmus; Nielsen, Christian

    2005-01-01

    I denne rapport undersøger vi hvilken hensigt, Giovanni Pico della Mirandola havde med at opstille og disputere over sine 900 teser. Vi tager udgangspunkt i hans tale Om menneskets værdighed, der skulle fungere som indledning til disputationen om teserne. Vi undersøger og diskuterer Picos brug af kabbalaen og andre ikke-kristne tekster, og hvorvidt han var kristen eller ej. Vi analyserer Om menneskets værdighed for også at finde ud af om Pico ville provokere, reformere eller bevare den katols...

  15. Development of high current beam ns pulsed system

    CERN Document Server

    Shen Guan Ren; Gao Fu; Guan Xia Ling; LiuNaiYi

    2001-01-01

    The development of high current beam ns pulsed system of CPNG and its characteristic, main technological performance and application are introduced. Firstly, important parameters of the system are calculated using theoretical model, the design requirements of some important parts are understood. Some mistakes in physics conception are corrected. Second, the chopper is designed for parallel plate deflector, chopping aperture and sine wave voltage sweeping device. It is emphasized that the conception of parallel plate load impedance is the capacitance load, but not the 50 ohm load impedance. The dynamic capacitance value has been measured. The output emphasizes the output voltage amplitude, but not the output power for sweeping device. The display system of output sweeping voltage was set up and it is sure that the maximum output voltage(V-V) is >=4000 V. The klystron buncher are re-designed. It is emphasized to overcome difficulty of support high voltage electrode in the klystron and insulator of input sine wa...

  16. Reducing the beam current in Linac4 in pulse to pulse mode.

    CERN Document Server

    Lallement, JB; CERN. Geneva. BE Department

    2009-01-01

    In order to deliver different beam intensities to users, we studied the possibility of varying the Linac4 beam current at PS Booster injection in pulse to pulse mode. This report gives the possible configurations of Linac4 Low and Medium Energy Beam Transport lines (LEBT and MEBT) that lead to a consistent current reduction.

  17. Direct-current proton-beam measurements at Los Alamos

    Energy Technology Data Exchange (ETDEWEB)

    Sherman, J.; Stevens, R.R.; Schneider, J.D.; Zaugg, T.

    1994-08-01

    Recently, a CW proton accelerator complex was moved from Chalk River Laboratories (CRL) to Los Alamos National Laboratory. This includes a 50-keV dc proton injector with a single-solenoid low-energy beam transport system (LEBT) and a CW 1.25-MeV, 267-MHz radiofrequency quadrupole (RFQ). The move was completed after CRL had achieved 55-mA CW operation at 1.25 MeV using 250-kW klystrode tubes to power the RFQ. These accelerator components are prototypes for the front end of a CW linac required for an accelerator-driven transmutation linac, and they provide early confirmation of some CW accelerator components. The injector (ion source and LEBT) and emittance measuring unit are installed and operational at Los Alamos. The dc microwave ion source has been operated routinely at 50-keV, 75-mA hydrogen-ion current. This ion source has demonstrated very good discharge and H{sub 2} gas efficiencies, and sufficient reliability to complete CW RFQ measurements at CRL. Proton fraction of 75% has been measured with 550-W discharge power. This high proton fraction removes the need for an analyzing magnet. Proton LEBT emittance measurements completed at Los Alamos suggest that improved transmission through the RFQ may be achieved by increasing the solenoid focusing current. Status of the final CW RFQ operation at CRL and the installation of the RFQ at Los Alamos is given.

  18. Experimental Verification of Current Shear Design Equations for HSRC Beams

    Directory of Open Access Journals (Sweden)

    Attaullah Shah

    2012-07-01

    Full Text Available Experimental research on the shear capacity of HSRC (High Strength Reinforced Concrete beams is relatively very limited as compared to the NSRC (Normal Strength Reinforced Concrete beams. Most of the Building Codes determine the shear strength of HSRC with the help of empirical equations based on experimental work of NSRC beams and hence these equations are generally regarded as un-conservative for HSRC beams particularly at low level of longitudinal reinforcement. In this paper, 42 beams have been tested in two sets, such that in 21 beams no transverse reinforcement has been used, whereas in the remaining 21 beams, minimum transverse reinforcement has been used as per ACI-318 (American Concrete Institute provisions. Two values of compressive strength 52 and 61 MPa, three values of longitudinal steel ratio and seven values of shear span to depth ratio have been have been used. The beams were tested under concentrated load at the mid span. The results are compared with the equations proposed by different international building codes like ACI, AASHTO LRFD, EC (Euro Code, Canadian Code and Japanese Code for shear strength of HSRC beams.From comparison, it has been observed that some codes are less conservative for shear design of HSRC beams and further research is required to rationalize these equations.

  19. cAMP/PKA Pathways and S56 Phosphorylation Are Involved in AA/PGE2-Induced Increases in rNaV1.4 Current.

    Directory of Open Access Journals (Sweden)

    Hua Gu

    Full Text Available Arachidonic acid (AA and its metabolites are important second messengers for ion channel modulation. The effects of extracellular application of AA and its non-metabolized analogue on muscle rNaV1.4 Na+ current has been studied, but little is known about the effects of intracellular application of AA on this channel isoform. Here, we report that intracellular application of AA significantly augmented the rNaV1.4 current peak without modulating the steady-state activation and inactivation properties of the rNaV1.4 channel. These results differed from the effects of extracellular application of AA on rNaV1.4 current. The effects of intracellular AA were mimicked by prostaglandin E2 but not eicosatetraynoic acid (ETYA, the non-metabolized analogue of AA, and were eliminated by treatment with cyclooxygenase inhibitors, flufenamic acid, or indomethacin. AA/PGE2-induced activation of rNaV1.4 channels was mimicked by a cAMP analogue (db-cAMP and eliminated by a PKA inhibitor, PKAi. Furthermore, inhibition of EP2 and EP4 (PGE2 receptors with AH6809 and AH23848 reduced the intracellular AA/PGE2-induced increase of rNaV1.4 current. Two mutated channels, rNaV1.4S56A and rNaV1.4T21A, were designed to investigate the role of predicted phosphorylation sites in the AA/PGE2-mediated regulation of rNaV1.4 currents. In rNaV1.4S56A, the effects of intracellular db-cAMP, AA, and PGE2 were significantly reduced. The results of the present study suggest that intracellular AA augments rNaV1.4 current by PGE2/EP receptor-mediated activation of the cAMP/PKA pathway, and that the S56 residue on the channel protein is important for this process.

  20. cAMP/PKA Pathways and S56 Phosphorylation Are Involved in AA/PGE2-Induced Increases in rNaV1.4 Current.

    Science.gov (United States)

    Gu, Hua; Fang, Yan-Jia; Liu, Dong-Dong; Chen, Ping; Mei, Yan-Ai

    2015-01-01

    Arachidonic acid (AA) and its metabolites are important second messengers for ion channel modulation. The effects of extracellular application of AA and its non-metabolized analogue on muscle rNaV1.4 Na+ current has been studied, but little is known about the effects of intracellular application of AA on this channel isoform. Here, we report that intracellular application of AA significantly augmented the rNaV1.4 current peak without modulating the steady-state activation and inactivation properties of the rNaV1.4 channel. These results differed from the effects of extracellular application of AA on rNaV1.4 current. The effects of intracellular AA were mimicked by prostaglandin E2 but not eicosatetraynoic acid (ETYA), the non-metabolized analogue of AA, and were eliminated by treatment with cyclooxygenase inhibitors, flufenamic acid, or indomethacin. AA/PGE2-induced activation of rNaV1.4 channels was mimicked by a cAMP analogue (db-cAMP) and eliminated by a PKA inhibitor, PKAi. Furthermore, inhibition of EP2 and EP4 (PGE2 receptors) with AH6809 and AH23848 reduced the intracellular AA/PGE2-induced increase of rNaV1.4 current. Two mutated channels, rNaV1.4S56A and rNaV1.4T21A, were designed to investigate the role of predicted phosphorylation sites in the AA/PGE2-mediated regulation of rNaV1.4 currents. In rNaV1.4S56A, the effects of intracellular db-cAMP, AA, and PGE2 were significantly reduced. The results of the present study suggest that intracellular AA augments rNaV1.4 current by PGE2/EP receptor-mediated activation of the cAMP/PKA pathway, and that the S56 residue on the channel protein is important for this process.

  1. Temperature calculations of heat loads in rotating target wheels exposed to high beam currents.

    Energy Technology Data Exchange (ETDEWEB)

    Greene, J. P.; Gabor, R.; Neubauer, J.

    2000-11-29

    In heavy-ion physics, high beam currents can eventually melt or destroy the target. Tightly focused beams on stationary targets of modest melting point will exhibit short lifetimes. Defocused or wobbled beams are employed to enhance target survival. Rotating targets using large diameter wheels can help overcome target melting and allow for higher beam currents to be used in experiments. The purpose of the calculations in this work is to try and predict the safe maximum beam currents which produce heat loads below the melting point of the target material.

  2. Resistive wall heating due to image current on the beam chamber for a superconducting undulator.

    Energy Technology Data Exchange (ETDEWEB)

    Kim, S. H. (Accelerator Systems Division (APS))

    2012-03-27

    The image-current heating on the resistive beam chamber of a superconducting undulator (SCU) was calculated based on the normal and anomalous skin effects. Using the bulk resistivity of copper for the beam chamber, the heat loads were calculated for the residual resistivity ratios (RRRs) of unity at room temperature to 100 K at a cryogenic temperature as the reference. Then, using the resistivity of the specific aluminum alloy 6053-T5, which will be used for the SCU beam chamber, the heat loads were calculated. An electron beam stored in a storage ring induces an image current on the inner conducting wall, mainly within a skin depth, of the beam chamber. The image current, with opposite charge to the electron beam, travels along the chamber wall in the same direction as the electron beam. The average current in the storage ring consists of a number of bunches. When the pattern of the bunched beam is repeated according to the rf frequency, the beam current may be expressed in terms of a Fourier series. The time structure of the image current is assumed to be the same as that of the beam current. For a given resistivity of the chamber inner wall, the application ofthe normal or anomalous skin effect will depend on the harmonic numbers of the Fourier series of the beam current and the temperature of the chamber. For a round beam chamber with a ratius r, much larger than the beam size, one can assume that the image current density as well as the density square, may be uniform around the perimeter 2{pi}r. For the SCU beam chamber, which has a relatively narrow vertical gap compared to the width, the effective perimeter was estimated since the heat load should be proportional to the inverse of the perimeter.

  3. Resistive wall heating due to image current on the beam chamber for a superconducting undulator.

    Energy Technology Data Exchange (ETDEWEB)

    Kim, S. H. (Accelerator Systems Division (APS))

    2012-03-27

    The image-current heating on the resistive beam chamber of a superconducting undulator (SCU) was calculated based on the normal and anomalous skin effects. Using the bulk resistivity of copper for the beam chamber, the heat loads were calculated for the residual resistivity ratios (RRRs) of unity at room temperature to 100 K at a cryogenic temperature as the reference. Then, using the resistivity of the specific aluminum alloy 6053-T5, which will be used for the SCU beam chamber, the heat loads were calculated. An electron beam stored in a storage ring induces an image current on the inner conducting wall, mainly within a skin depth, of the beam chamber. The image current, with opposite charge to the electron beam, travels along the chamber wall in the same direction as the electron beam. The average current in the storage ring consists of a number of bunches. When the pattern of the bunched beam is repeated according to the rf frequency, the beam current may be expressed in terms of a Fourier series. The time structure of the image current is assumed to be the same as that of the beam current. For a given resistivity of the chamber inner wall, the application ofthe normal or anomalous skin effect will depend on the harmonic numbers of the Fourier series of the beam current and the temperature of the chamber. For a round beam chamber with a ratius r, much larger than the beam size, one can assume that the image current density as well as the density square, may be uniform around the perimeter 2{pi}r. For the SCU beam chamber, which has a relatively narrow vertical gap compared to the width, the effective perimeter was estimated since the heat load should be proportional to the inverse of the perimeter.

  4. Controlling hollow relativistic electron beam orbits with an inductive current divider

    Energy Technology Data Exchange (ETDEWEB)

    Swanekamp, S. B.; Richardson, A. S.; Angus, J. R.; Cooperstein, G.; Hinshelwood, D. D.; Ottinger, P. F.; Rittersdorf, I. M.; Schumer, J. W.; Weber, B. V.; Zier, J. C. [Plasma Physics Division, Naval Research Laboratory, Washington, DC 20375 (United States)

    2015-02-15

    A passive method for controlling the trajectory of an intense, hollow electron beam is proposed using a vacuum structure that inductively splits the beam's return current. A central post carries a portion of the return current (I{sub 1}), while the outer conductor carries the remainder (I{sub 2}). An envelope equation appropriate for a hollow electron beam is derived and applied to the current divider. The force on the beam trajectory is shown to be proportional to (I{sub 2}-I{sub 1}), while the average force on the envelope (the beam width) is proportional to the beam current I{sub b} = (I{sub 2} + I{sub 1}). The values of I{sub 1} and I{sub 2} depend on the inductances in the return-current path geometries. Proper choice of the return-current geometries determines these inductances and offers control over the beam trajectory. Solutions using realistic beam parameters show that, for appropriate choices of the return-current-path geometry, the inductive current divider can produce a beam that is both pinched and straightened so that it approaches a target at near-normal incidence with a beam diameter that is on the order of a few mm.

  5. Cryogenic Current Comparator as Low Intensity Beam Current Monitor in the CERN Antiproton Decelerators

    CERN Document Server

    Fernandes, M; Soby, L; Welsch, CP

    2013-01-01

    In the low-energy Antiproton Decelerator (AD) and the future Extra Low ENergy Antiproton (ELENA) rings at CERN, an absolute measurement of the beam intensity is essential to monitor any losses during the deceleration and cooling phases. However, existing DC current transformers can hardly reach the μA level, while at the AD and ELENA currents can be as low as 100 nA. A Cryogenic Current Comparator (CCC) based on a superconducting quantum interference device (SQUID) is currently being designed and shall be installed in the AD and ELENA machines. It should meet the following specifications: A current resolution smaller than 10 nA, a dynamic range covering currents between 100 nA and 1 mA, as well as a bandwidth from DC to 1 kHz. Different design options are being considered, including the use of low or high temperature superconductor materials, different CCC shapes and dimensions, different SQUID characteristics, as well as electromagnetic shielding requirements. In this contribution we present first results f...

  6. Proton beam therapy in Japan: current and future status.

    Science.gov (United States)

    Sakurai, Hideyuki; Ishikawa, Hitoshi; Okumura, Toshiyuki

    2016-10-01

    The number of patients treated by proton beam therapy in Japan since 2000 has increased; in 2016, 11 proton facilities were available to treat patients. Notably, proton beam therapy is very useful for pediatric cancer; since the pediatric radiation dose to normal tissues should be reduced as much as possible because of the effect of radiation on growth, intellectual development, endocrine organ function and secondary cancer development. Hepatocellular carcinoma is common in Asia, and most of the studies of proton beam therapy for liver cancer have been reported by Japanese investigators. Proton beam therapy is also a standard treatment for nasal and paranasal lesions and lesions at the base of the skull, because the radiation dose to critical organs such as the eyes, optic nerves and central nervous system can be reduced with proton beam therapy. For prostate cancer, comparative studies that address adverse effects, safety, patient quality of life and socioeconomic issues should be performed to determine the appropriate use of proton beam therapy for prostate cancer. Regarding new proton beam therapy applications, experience with proton beam therapy combined with chemotherapy is limited, although favorable outcomes have been recently reported for locally advanced lung cancer, esophageal cancer and pancreatic cancer. Therefore, 'chemoproton' therapy appears to be a very attractive field for further clinical investigations. In conclusion, there are cost issues and considerations regarding national insurance for the use of proton beam therapy in Japan. Further studies and discussions are needed to address the use of proton beam therapy for several types of cancers, and for maintaining the quality of life of patients while retaining a high cure rate.

  7. Fast-ion transport and neutral beam current drive in ASDEX upgrade

    DEFF Research Database (Denmark)

    Geiger, B.; Weiland, M.; Jacobsen, Asger Schou

    2015-01-01

    The neutral beam current drive efficiency has been investigated in the ASDEX Upgrade tokamak by replacing on-axis neutral beams with tangential off-axis beams. A clear modification of the radial fast-ion profiles is observed with a fast-ion D-alpha diagnostic that measures centrally peaked profil...

  8. Censorship: Post Pico.

    Science.gov (United States)

    Terry, John David, II

    The 1982 Supreme Court decision in "Pico v. Island Trees Union Free School District" occasioned an ideological war over interpretation of the First Amendment, but a review indicates that it is an additional case in the long-standing attempt to find the proper balance between the amendment and the efficiencies of government. In…

  9. Particle-in-cell simulations of electron beam control using an inductive current divider

    Energy Technology Data Exchange (ETDEWEB)

    Swanekamp, S. B.; Angus, J. R.; Cooperstein, G.; Ottinger, P. F.; Richardson, A. S.; Schumer, J. W.; Weber, B. V. [Plasma Physics Division, Naval Research Laboratory, Washington, District of Columbia 20375 (United States)

    2015-11-15

    Kinetic, time-dependent, electromagnetic, particle-in-cell simulations of the inductive current divider are presented. The inductive current divider is a passive method for controlling the trajectory of an intense, hollow electron beam using a vacuum structure that inductively splits the beam's return current. The current divider concept was proposed and studied theoretically in a previous publication [Swanekamp et al., Phys. Plasmas 22, 023107 (2015)]. A central post carries a portion of the return current (I{sub 1}), while the outer conductor carries the remainder (I{sub 2}) with the injected beam current given by I{sub b} = I{sub 1} + I{sub 2}. The simulations are in agreement with the theory which predicts that the total force on the beam trajectory is proportional to (I{sub 2}−I{sub 1}) and the force on the beam envelope is proportional to I{sub b}. Independent control over both the current density and the beam angle at the target is possible by choosing the appropriate current-divider geometry. The root-mean-square (RMS) beam emittance (ε{sub RMS}) varies as the beam propagates through the current divider to the target. For applications where control of the beam trajectory is desired and the current density at the target is similar to the current density at the entrance foil, there is a modest 20% increase in ε{sub RMS} at the target. For other applications where the beam is pinched to a current density ∼5 times larger at the target, ε{sub RMS} is 2–3 times larger at the target.

  10. Estado actual del PET en los tumores de cabeza y cuello: impacto en la planificación del tratamiento radioterápico Current state of PET in head and neck tumours: impact on the planning of radiotherapy treatment

    Directory of Open Access Journals (Sweden)

    F. Arias de la Vega

    2009-01-01

    Full Text Available El uso de la tomografía de emisión de positrones (PET en los tumores de cabeza y cuello está cada vez más extendido. A sus indicaciones clínicas -especialmente en el estadiaje de los pacientes pero también en la valoración de la respuesta al tratamiento y en la detección o confirmación de recidivas-, se une ahora el posible impacto terapéutico a través de su aportación en la planificación del tratamiento radioterápico. La integración de las imágenes del PET en el proceso radioterápico parece prometedora, aunque persisten importantes dudas acerca del mismo que hacen que de momento se reserve al campo de la investigación. En este trabajo se revisa el estado actual del PET en el área de los tumores de cabeza y cuello, así como su impacto en la planificación del tratamiento radioterápico.The use of positron emission tomography (PET in head and neck tumours is increasingly widespread. To its clinical indications -especially in the staging of patients but also in evaluating response to treatment and in detecting or confirming relapses- is now added its possible therapeutic impact through its contribution to the planning of radiotherapy treatment. The integration of PET images in the radiotherapy process seems promising, although important doubts remain about it, which means that it is still under research. This article reviews the current state of PET in the area of head and neck tumours, as well as its impact on radiotherapy treatment planning.

  11. Generation of Ramped Current Profiles in Relativistic Electron Beams Using Wakefields in Dielectric Structures.

    Science.gov (United States)

    Andonian, G; Barber, S; O'Shea, F H; Fedurin, M; Kusche, K; Swinson, C; Rosenzweig, J B

    2017-02-03

    Temporal pulse tailoring of charged-particle beams is essential to optimize efficiency in collinear wakefield acceleration schemes. In this Letter, we demonstrate a novel phase space manipulation method that employs a beam wakefield interaction in a dielectric structure, followed by bunch compression in a permanent magnet chicane, to longitudinally tailor the pulse shape of an electron beam. This compact, passive, approach was used to generate a nearly linearly ramped current profile in a relativistic electron beam experiment carried out at the Brookhaven National Laboratory Accelerator Test Facility. Here, we report on these experimental results including beam and wakefield diagnostics and pulse profile reconstruction techniques.

  12. Generation of Ramped Current Profiles in Relativistic Electron Beams Using Wakefields in Dielectric Structures

    Science.gov (United States)

    Andonian, G.; Barber, S.; O'Shea, F. H.; Fedurin, M.; Kusche, K.; Swinson, C.; Rosenzweig, J. B.

    2017-02-01

    Temporal pulse tailoring of charged-particle beams is essential to optimize efficiency in collinear wakefield acceleration schemes. In this Letter, we demonstrate a novel phase space manipulation method that employs a beam wakefield interaction in a dielectric structure, followed by bunch compression in a permanent magnet chicane, to longitudinally tailor the pulse shape of an electron beam. This compact, passive, approach was used to generate a nearly linearly ramped current profile in a relativistic electron beam experiment carried out at the Brookhaven National Laboratory Accelerator Test Facility. Here, we report on these experimental results including beam and wakefield diagnostics and pulse profile reconstruction techniques.

  13. Cone beam CT in orthodontics: the current picture.

    Science.gov (United States)

    Makdissi, Jimmy

    2013-03-01

    The introduction of cone beam computed tomography (CBCT) technology to dentistry and orthodontics revolutionized the diagnosis, treatment and monitoring of orthodontic patients. This review article discusses the use of CBCT in diagnosis and treatment planning in orthodontics. The steps required to install and operate a CBCT facility within the orthodontic practice as well as the challenges are highlighted. The available guidelines in relation to the clinical applications of CBCT in orthodontics are explored. Copyright © 2013. Published by Elsevier Masson SAS.

  14. A 128-channel picoammeter system and its application on charged particle beam current distribution measurements

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Deyang, E-mail: d.yu@impcas.ac.cn; Liu, Junliang; Xue, Yingli; Zhang, Mingwu; Cai, Xiaohong; Hu, Jianjun; Dong, Jinmei [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Li, Xin [School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000 (China)

    2015-11-15

    A 128-channel picoammeter system is constructed based on instrumentation amplifiers. Taking advantage of a high electric potential and narrow bandwidth in DC energetic charged beam measurements, a current resolution better than 5 fA can be achieved. Two sets of 128-channel strip electrodes are implemented on printed circuit boards and are employed for ion and electron beam current distribution measurements. Tests with 60 keV O{sup 3+} ions and 2 keV electrons show that it can provide exact boundaries when a positive charged particle beam current distribution is measured.

  15. A 128-channel picoammeter system and its application on charged particle beam current distribution measurements

    CERN Document Server

    Yu, Deyang; Xue, Yingli; Zhang, Mingwu; Cai, Xiaohong; Hu, Jianjun; Dong, Jinmei; Li, Xin

    2015-01-01

    A 128-channel picoammeter system is constructed based on instrumentation amplifiers. Taking the advantages of high electric potential and narrow bandwidth in DC energetic charged beam measurements, current resolution better than 5 fA can be achieved. Two 128-channel Faraday cup arrays are built, and are employed for ion and electron beam current distribution measurements. Tests with 60 keV O3+ ions and 2 keV electrons show that it can provide exact boundaries when a positive charged particle beam current distribution is measured.

  16. Point discharge current measurements beneath dust devils

    Science.gov (United States)

    Lorenz, Ralph D.; Neakrase, Lynn D. V.; Anderson, John P.; Harrison, R. Giles; Nicoll, Keri A.

    2016-12-01

    We document for the first time observations of point discharge currents under dust devils using a novel compact sensor deployed in summer 2016 at the USDA-ARS Jornada Experimental Range in New Mexico, USA. A consistent signature is noted in about a dozen events seen over 40 days, with a positive current ramping up towards closest approach, switching to a decaying negative current as the devil recedes. The currents, induced on a small wire about 10 cm above the ground, correlate with dust devil intensity (pressure drop) and dust loading, and reached several hundred picoAmps.

  17. Electromagnetic and beam dynamics studies of a high current drift tube linac for LEHIPA

    Science.gov (United States)

    Roy, S.; Rao, S. V. L. S.; Pande, R.; Krishnagopal, S.; Singh, P.

    2014-06-01

    We have performed detailed electromagnetic and beam dynamics studies of a 352.21 MHz drift-tube linac (DTL) that will accelerate a 30 mA CW proton beam from 3 to 20 MeV. At such high currents space charge effects are important, and therefore the effect of linear as well as non-linear space charge has been studied (corresponding to uniform and Gaussian initial beam distributions), in order to avoid space charge instabilities. To validate the electromagnetic simulations, a 1.2 m long prototype of the DTL was fabricated. RF measurements performed on the prototype were in good agreement with the simulations. A detailed simulation study of beam halos was also performed, which showed that beyond a current of 10 mA, significant longitudinal beam halos are excited even for a perfectly matched beam, whereas for a mis-matched beam transverse beam halos are also excited. However, these do not lead to any beam loss within the DTL.

  18. One Pico Dinner Menu 2013

    OpenAIRE

    O'Reilly, Eamonn

    2013-01-01

    One Pico is Multi award winning fine dining restaurant of national & international repute combining efficient French decorum with a warm & welcoming athmosphere, We serve modern classic cuisine with innovative touches using the best of Local produce in season with menu's changing by the month and always offering our customers value. Located off St Stephens Green on schoolhouse lane & next to The Dawson car park One Pico is open for lunch and dinner Monday to Sunday. One Pico has its own pr...

  19. DEVELOPMENT OF ACCELERATOR DATA REPORTING SYSTEM AND ITS APPLICATION TO TREND ANALYSIS OF BEAM CURRENT DATA

    Energy Technology Data Exchange (ETDEWEB)

    Padilla, M.J.; Blokland, W.

    2009-01-01

    Detailed ongoing information about the ion beam quality is crucial to the successful operation of the Spallation Neutron Source at Oak Ridge National Laboratory. In order to provide the highest possible neutron production time, ion beam quality is monitored to isolate possible problems or performance-related issues throughout the accelerator and accumulator ring. For example, beam current monitor (BCM) data is used to determine the quality of the beam transport through the accelerator. In this study, a reporting system infrastructure was implemented and used to generate a trend analysis report of the BCM data. The BCM data was analyzed to facilitate the identifi cation of monitor calibration issues, beam trends, beam abnormalities, beam deviations and overall beam quality. A comparison between transformed BCM report data and accelerator log entries shows promising results which represent correlations between the data and changes made within the accelerator. The BCM analysis report is one of many reports within a system that assist in providing overall beam quality information to facilitate successful beam operation. In future reports, additional data manipulation functions and analysis can be implemented and applied. Built-in and user-defi ned analytic functions are available throughout the reporting system and can be reused with new data.

  20. Simulation of Electron Beam Dynamics in a Nonmagnetized High-Current Vacuum Diode

    CERN Document Server

    Anishchenko, Sergey

    2016-01-01

    The electron beam dynamics in a nonmagnetized high-current vacuum diode is analyzed for different cathode-anode gap geometries. The conditions enabling to achieve the minimal {initial} momentum spread in the electron beam are found out. A drastic rise of current density in a vacuum diode with a ring-type cathode is described. The effect is shown to be caused by electrostatic repulsion.

  1. The Pico's formula Generalization

    OpenAIRE

    Sergiu Cataranciuc; Marina Holban

    2007-01-01

    The Pico formula generalizations are obtained for area calculation of a polygon P through the determination of special nodes of the network in which this P is placed. The case of the polygon with rational coordinates of its vertexes is examined, as well as the case of the polygon with holes. In the case of three-dimensional space a formula of volume calculation for some polyhedrons, such as prism and tetrahedron is presented. On the basis of theoretic outcomes an algorithm that can be applied...

  2. The Pico's formula Generalization

    Directory of Open Access Journals (Sweden)

    Sergiu Cataranciuc

    2007-04-01

    Full Text Available The Pico formula generalizations are obtained for area calculation of a polygon P through the determination of special nodes of the network in which this P is placed. The case of the polygon with rational coordinates of its vertexes is examined, as well as the case of the polygon with holes. In the case of three-dimensional space a formula of volume calculation for some polyhedrons, such as prism and tetrahedron is presented. On the basis of theoretic outcomes an algorithm that can be applied in calculation for areas of plane figure is elaborated.

  3. Fast range switching of passively scattered proton beams using a modulation wheel and dynamic beam current modulation

    Science.gov (United States)

    Sánchez-Parcerisa, D.; Pourbaix, J. C.; Ainsley, C. G.; Dolney, D.; Carabe, A.

    2014-04-01

    In proton radiotherapy, the range of particles in the patient body is determined by the energy of the protons. For most systems, the energy selection time is on the order of a few seconds, which becomes a serious obstacle for continuous dose delivery techniques requiring adaptive range modulation. This work analyses the feasibility of using the range modulation wheel, an element in the beamline used to form the spread-out Bragg peak (SOBP), to produce near-instantaneous changes not only in the modulation, but also in the range of the beam. While delivering proton beams in double scattering mode, the beam current can be synchronized with the range modulation wheel rotation by defining a current modulation pattern. Different current modulation patterns were computed from Monte Carlo simulations of our double scattering nozzle to range shift an SOBP of initial range 15 cm by varying degrees of up to ˜9 cm. These patterns were passed to the treatment control system at our institution and the resulting measured depth-dose distributions were analysed in terms of flatness, distal penumbra and relative irradiation time per unit mid-SOBP dose. Suitable SOBPs were obtained in all cases, with the maximum range shift being limited only by the maximum thickness of the wheel. The distal dose fall-off (80% to 20%) of the shifted peaks was broadened to about 1 cm, from the original 0.5 cm, and the predicted overhead in delivery time showed a linear increase with the amount of the shift. By modulating the beam current in clinical scattered proton beams equipped with a modulation wheel, it is possible to dynamically modify the in-patient range of the SOBP without adding any specific hardware or compensators to the beamline. A compromise between sharper distal dose fall-off and lower delivery time can be achieved and is subject to optimization.

  4. Fast range switching of passively scattered proton beams using a modulation wheel and dynamic beam current modulation.

    Science.gov (United States)

    Sánchez-Parcerisa, D; Pourbaix, J C; Ainsley, C G; Dolney, D; Carabe, A

    2014-04-01

    In proton radiotherapy, the range of particles in the patient body is determined by the energy of the protons. For most systems, the energy selection time is on the order of a few seconds, which becomes a serious obstacle for continuous dose delivery techniques requiring adaptive range modulation. This work analyses the feasibility of using the range modulation wheel, an element in the beamline used to form the spread-out Bragg peak (SOBP), to produce near-instantaneous changes not only in the modulation, but also in the range of the beam. While delivering proton beams in double scattering mode, the beam current can be synchronized with the range modulation wheel rotation by defining a current modulation pattern. Different current modulation patterns were computed from Monte Carlo simulations of our double scattering nozzle to range shift an SOBP of initial range 15 cm by varying degrees of up to ∼9 cm. These patterns were passed to the treatment control system at our institution and the resulting measured depth-dose distributions were analysed in terms of flatness, distal penumbra and relative irradiation time per unit mid-SOBP dose. Suitable SOBPs were obtained in all cases, with the maximum range shift being limited only by the maximum thickness of the wheel. The distal dose fall-off (80% to 20%) of the shifted peaks was broadened to about 1 cm, from the original 0.5 cm, and the predicted overhead in delivery time showed a linear increase with the amount of the shift. By modulating the beam current in clinical scattered proton beams equipped with a modulation wheel, it is possible to dynamically modify the in-patient range of the SOBP without adding any specific hardware or compensators to the beamline. A compromise between sharper distal dose fall-off and lower delivery time can be achieved and is subject to optimization.

  5. Nano-electron beam induced current and hole charge dynamics through uncapped Ge nanocrystals

    Energy Technology Data Exchange (ETDEWEB)

    Marchand, A.; El Hdiy, A.; Troyon, M. [Laboratoire de Recherche en Nanosciences, Bat. 6, case no 15, UFR Sciences, Universite de Reims Champagne Ardenne, 51687 Reims Cedex 2 (France); Amiard, G.; Ronda, A.; Berbezier, I. [IM2NP, Faculte des Sciences et Techniques, Campus de Saint Jerome - Case 142, Avenue Escadrille Normandie Niemen, 13397 Marseille Cedex 20 (France)

    2012-04-16

    Dynamics of hole storage in spherical Ge nanocrystals (NCs) formed by a two step dewetting/nucleation process on an oxide layer grown on an n-doped <001> silicon substrate is studied using a nano-electron beam induced current technique. Carrier generation is produced by an electron beam irradiation. The generated current is collected by an atomic force microscope--tip in contact mode at a fixed position away from the beam spot of about 0.5 {mu}m. This distance represents the effective diffusion length of holes. The time constants of holes charging are determined and the effect of the NC size is underlined.

  6. Using pico-LCoS SLMs for high speed cell sorting

    DEFF Research Database (Denmark)

    Bañas, Andrew Rafael; Aabo, Thomas; Palima, Darwin

    2012-01-01

    We propose the use of consumer pico projectors as cost effective spatial light modulators in cell sorting applications. The matched filtering Generalized Phase Contrast (mGPC) beam shaping method is used to produce high intensity optical spots for trapping and catapulting cells. A pico projector...

  7. Return-current formation in the electron beam – plasma system

    Directory of Open Access Journals (Sweden)

    M. Bárta

    2009-07-01

    Full Text Available Using a 3-D electromagnetic particle-in-cell model an evolution of the electron distribution function in the beam-plasma system with the return current is computed. It was found that the resulting electron distribution function depends on the magnetic field assumed along the beam-propagation direction. While for small magnetic fields the electron distribution function becomes broad in the direction perpendicular to the beam propagation due to the Weibel (filamentation instability and the return current is formed by a shifted bulk distribution, for stronger magnetic fields the distribution, especially on the return current side, is extended in the beam-propagation direction. To understand better the instabilities influencing the mentioned processes, the dispersion diagrams are computed and discussed.

  8. Influence of total beam current on HRTEM image resolution in differentially pumped ETEM with nitrogen gas.

    Science.gov (United States)

    Bright, A N; Yoshida, K; Tanaka, N

    2013-01-01

    Environmental transmission electron microscopy (ETEM) enables the study of catalytic and other reaction processes as they occur with Angstrom-level resolution. The microscope used is a dedicated ETEM (Titan ETEM, FEI Company) with a differential pumping vacuum system and apertures, allowing aberration corrected high-resolution transmission electron microscopy (HRTEM) imaging to be performed with gas pressures up to 20 mbar in the sample area and with significant advantages over membrane-type E-cell holders. The effect on image resolution of varying the nitrogen gas pressure, electron beam current density and total beam current were measured using information limit (Young's fringes) on a standard cross grating sample and from silicon crystal lattice imaging. As expected, increasing gas pressure causes a decrease in HRTEM image resolution. However, the total electron beam current also causes big changes in the image resolution (lower beam current giving better resolution), whereas varying the beam current density has almost no effect on resolution, a result that has not been reported previously. This behavior is seen even with zero-loss filtered imaging, which we believe shows that the drop in resolution is caused by elastic scattering at gas ions created by the incident electron beam. Suitable conditions for acquiring high resolution images in a gas environment are discussed. Lattice images at nitrogen pressures up to 16 mbar are shown, with 0.12 nm information transfer at 4 mbar.

  9. Effect of conductive screens on the stabilization of plasma channels with currents of hundreds kAmps

    Science.gov (United States)

    Bochkov, V. D.; Bochkov, D. V.; Krivosheev, S. I.; Adamian, Yu. E.

    2016-12-01

    Based on experimental data, we analyzed the results of the influence of external conductive shield on stabilization of plasma channels in high-power pseudospark switches—thyratrons TDI-type. Both no-ferrous and ferrous shields are tested. The research is a part of a work on improvement of switching capabilities of thyratrons capable of transferring currents up to hundreds kA with switching energy more than 50 kJ.

  10. Wideband Precision Current Transformer for the Magnet Current of the Beam Extraction Kicker Magnet of the Large Hadron Collider

    CERN Document Server

    Gräwer, G

    2004-01-01

    The LHC beam extraction system is composed of 15 fast kicker magnets per beam to extract the particles in one turn of the collider and to safely dispose them on external absorbers. Each magnet is powered by a separate pulse generator. The generator produces a magnet current pulse with 3 us rise time, 20 kA amplitude and 1.8 ms fall time, of which 90 us are needed to dump the beam. The beam extraction system requires a high level of reliability. To detect any change in the magnet current characteristics, which might indicate a slow degradation of the pulse generator, a high precision wideband current transformer will be installed. For redundancy reasons, the results obtained with this device will be cross-checked with a Rogowski coil, installed adjacent to the transformer. A prototype transformer has been successfully tested at nominal current levels and showed satisfactory results compared with the output of a high frequency resistive coaxial shunt. The annular core of the ring type transformer is composed of...

  11. Segmented Beam Dump for Time Resolved Spectrometry on a High Current Electron Beam

    CERN Document Server

    Lefèvre, T; Bravin, E; Braun, H H

    2008-01-01

    In the CLIC Test Facility 3 (CTF3), the strong coupling between the beam and the accelerating cavities induces transient effects such that the head of the pulse is accelerated twice as much as the rest of the pulse. Three spectrometer lines are installed along the linac with the aim of measuring energy spread versus time with a 20ns resolution. A major difficulty is due to the high power carried by the beam which imposes extreme constraints of thermal and radiation resistances on the detector. This paper presents the design and the performances of a simple and easy-to-maintain device, called ‘segmented dump'. In this device, the particles are stopped inside metallic plates and the deposited charge is measured in the same way as in Faraday cups. Simulations were carried out with the Monte Carlo code ‘FLUKA' to evaluate the problems arising from the energy deposition and to find ways to prevent or reduce them. The detector resolution was optimized by an adequate choice of material and thickness of the...

  12. Design and simulation of a beam position monitor for the high current proton linac

    Institute of Scientific and Technical Information of China (English)

    RUAN Yu-Fang; XU Tao-Guang; FU Shi-Nian

    2009-01-01

    In this paper, the 2-D electrostatic field software, POISSON, is used to calculate the characteristic impedance of a BPM (beam position monitor) for a high current proton linac. Furthermore, the time-domain 3-D module of MAFIA with a beam microbunch at a varying offset from the axis is used to compute the induced voltage on the electrodes as a function of time. Finally, the effect of low 13 beams on the induced voltage, the sensitivity and the signal dynamic range of the BPM are discussed.

  13. Current Control in ITER Steady State Plasmas With Neutral Beam Steering

    Energy Technology Data Exchange (ETDEWEB)

    R.V. Budny

    2009-09-10

    Predictions of quasi steady state DT plasmas in ITER are generated using the PTRANSP code. The plasma temperatures, densities, boundary shape, and total current (9 - 10 MA) anticipated for ITER steady state plasmas are specified. Current drive by negative ion neutral beam injection, lower-hybrid, and electron cyclotron resonance are calculated. Four modes of operation with different combinations of current drive are studied. For each mode, scans with the NNBI aimed at differing heights in the plasma are performed to study effects of current control on the q profile. The timeevolution of the currents and q are calculated to evaluate long duration transients. Quasi steady state, strongly reversed q profiles are predicted for some beam injection angles if the current drive and bootstrap currents are sufficiently large.

  14. Leakage Current Simulation of Insulating Thin Film Irradiated by a Nonpenetrating Electron Beam

    Institute of Scientific and Technical Information of China (English)

    ZHANG Hai-Bo; LI Wei-Qin; CAO Meng

    2012-01-01

    We perform numerical simulations of the leakage current characteristics of an insulating thin film of SiO2 negatively charged by a low-energy nonpenetrating focused electron beam. For the formation of leakage current, electrons are demonstrated to turn from diffusion to drift after clearing the minimum potential barrier due to electron-hole separation. In the equilibrium state, the leakage current increases approximately linearly with the increasing primary beam current and energy. It also increases with the increasing film thickness and trap density, and with the decreasing electron mobility, in which the film thickness has a greater influence. Validated by some existing experiments, the simulation results provide a new perspective for the negative charging effects of insulating samples due to the low-energy focused electron beam.%We perform numerical simulations of the leakage current characteristics of an insulating thin film of SiO2 negatively charged by a low-energy nonpenetrating focused electron beam.For the formation of leakage current,electrons are demonstrated to turn from diffusion to drift after clearing the minimum potential barrier due to electron-hole separation.In the equilibrium state,the leakage current increases approximately linearly with the increasing primary beam current and energy.It also increases with the increasing film thickness and trap density,and with the decreasing electron mobility,in which the film thickness has a greater influence.Validated by some existing experiments,the simulation results provide a new perspective for the negative charging effects of insulating samples due to the low-energy focused electron beam.

  15. Dopaminergic modulation of sodium current in hippocampal neurons via cAMP-dependent phosphorylation of specific sites in the sodium channel alpha subunit.

    Science.gov (United States)

    Cantrell, A R; Smith, R D; Goldin, A L; Scheuer, T; Catterall, W A

    1997-10-01

    Phosphorylation of brain Na+ channel alpha subunits by cAMP-dependent protein kinase (PKA) decreases peak Na+ current in cultured brain neurons and in mammalian cells and Xenopus oocytes expressing cloned brain Na+ channels. We have studied PKA regulation of Na+ channel function by activation of D1-like dopamine receptors in acutely isolated hippocampal neurons using whole-cell voltage-clamp recording techniques. The D1 agonist SKF 81297 reversibly reduced peak Na+ current in a concentration-dependent manner. No changes in the voltage dependence or kinetics of activation or inactivation were observed. This effect was mediated by PKA, as it was mimicked by application of the PKA activator Sp-5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3', 5'-monophosphorothioate(cBIMPS) and was inhibited by the specific PKA inhibitor peptide PKAI5-24. cBIMPS had similar effects on type IIA brain Na+ channel alpha subunits expressed in tsA-201 cells, but no effect was observed on a mutant Na+ channel alpha subunit in which serine residues in five PKA phosphorylation sites in the intracellular loop connecting domains I and II (LI-II) had been replaced by alanine. A single mutation, S573A, similarly eliminated cBIMPS modulation. Thus, activation of D1-like dopamine receptors results in PKA-dependent phosphorylation of specific sites in LI-II of the Na+ channel alpha subunit, causing a reduction in Na+ current. Such modulation is expected to exert a profound influence on overall neuronal excitability. Dopaminergic input to the hippocampus from the mesocorticolimbic system may exert this influence in vivo.

  16. High Dynamic Magnetic Beam Current Measurements by Means of Optimised Magneto-Resistance (MR) Sensor Engineering

    CERN Document Server

    Hape, M; Ricken, W

    2005-01-01

    The GSI-FAIR project (facility for antiprotons and ion research) will comprehend DC currents up to around 5 A in the SIS 100 synchrotron and after bunch compression down to 50 ns pulse length the peak currents will reach up to 100 A. To meet these higher demands of beam current measurements new sensor techniques are foreseen. The measurement device itself will be designed in form of a clip-on ampere-meter. The air gap of the flux concentrator is assumed to be around 5 mm and thus, the estimated maximum field therein is around 30 mT for a beam current of 100 A peak. The resolution of this device is aimed to be 1 mA in beam current, corresponding to a system dynamic of around 105. This high demands of beam current measurement require more sophisticated sensor types than just using a Hall probe. The characteristics of AMR (anisotropic magneto-resistance), GMR (giant magneto-resistance) and GMI (giant magneto-impedance) sensors like hysteresis, linearity and sensitivity have been measured within the magnetic fiel...

  17. Modulation of auroral electrojet currents using dual HF beams with ELF phase offset

    Science.gov (United States)

    Golkowski, M.; Cohen, M.; Moore, R. C.

    2012-12-01

    The modulation of naturally occuring ionospheric currents with high power radio waves in the high frequency (HF, 3-10 MHz) band is a well known technique for generation of extremely low frequency (ELF, 3-3000 Hz) and very low frequency (VLF, 3-30 kHz) waves. We use the heating facility of the High Frequency Active Auroral Research Program (HAARP) to investigate the effect of using dual HF beams with an ELF/VLF phase offset between the modulation waveforms. Experiments with offset HF beams confirm the model of independent ELF/VLF sources. Experiments with co-located HF beams exhibit interaction between the first and second harmonics of the modulated tones when square and sine wave modulation waveforms are employed. Using ELF/VLF phase offsets for co-loacted beams is also shown to be a potential diagnostic for the D-region ionospheric profile.

  18. Aberrations due to solenoid focusing of a multiply charged high-current ion beam

    CERN Document Server

    Grégoire, G; Lisi, N; Schnuriger, J C; Scrivens, R; Tambini, J

    2000-01-01

    At the output of a laser ion source, a high current of highly charged ions with a large range of charge states is available. The focusing of such a beam by magnetic elements causes a nonlinear space-charge field to develop which can induce large aberrations and emittance growth in the beam. Simulation of the beam from the CERN laser ion source will be presented for an ideal magnetic and electrostatic system using a radially symmetric model. In addition, the three dimensional software KOBRA3 is used for the simulation of the solenoid line. The results of these simulations will be compared with experiments performed on the CERN laser ion source with solenoids (resulting in a hollow beam) and a series of gridded electrostatic lenses. (5 refs).

  19. A Particle In Cell code development for high current ion beam transport and plasma simulations

    CERN Document Server

    Joshi, N

    2016-01-01

    A simulation package employing a Particle in Cell (PIC) method is developed to study the high current beam transport and the dynamics of plasmas. This package includes subroutines those are suited for various planned projects at University of Frankfurt. In the framework of the storage ring project (F8SR) the code was written to describe the beam optics in toroidal magnetic fields. It is used to design an injection system for a ring with closed magnetic field lines. The generalized numerical model, in Cartesian coordinates is used to describe the intense ion beam transport through the chopper system in the low energy beam section of the FRANZ project. Especially for the chopper system, the Poisson equation is implemented with irregular geometries. The Particle In Cell model is further upgraded with a Monte Carlo Collision subroutine for simulation of plasma in the volume type ion source.

  20. Ultrahigh-current proton beams from short-pulse laser-solid interactions

    Energy Technology Data Exchange (ETDEWEB)

    Badziak, J; Jablowski, S; Parys, P; Rosinski, M; Suchanska, R; Wolowski, J [Institute of Plasma Physics and Laser Microfusion, EURATOM Association, Warsaw (Poland); Antici, P; Fuchs, J; Lancia, L; Mancic, A [LULI, Ecole Polytechnique, CNRS, CEA, UPMC, Route de Saclay, 91128 Palaiseau (France); Szydlowski, A [Andrzej Soltan Institute for Nuclear Studies, Warsaw (Poland)], E-mail: badziak@ifpilm.waw.pl

    2008-05-01

    The results of studies of high-current proton beam generation from thin (1-3{mu}m) solid targets irradiated by 0.35-ps laser pulse of intensity up to 2x10{sup 19} W/cm{sup 2} are reported. It is shown that the proton beams of multi-MA currents and multi-TA/cm{sup 2} current densities at the source can be produced when the laser-target interaction conditions approach the skin-layer ponderomotive acceleration requirements. The current and energy spectrum of protons remarkably depend on the target structure. In particular, using a double-layer Au/PS target (plastic covered by 0.1 - 0.2{mu}m Au front layer) results in two-fold higher proton currents and higher proton energies than in the case of a plastic target.

  1. A Four Channel Beam Current Monitor Data Acquisition System Using Embedded Processors

    Energy Technology Data Exchange (ETDEWEB)

    Wheat, Jr., Robert Mitchell [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dalmas, Dale A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dale, Gregory E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-08-11

    Data acquisition from multiple beam current monitors is required for electron accelerator production of Mo-99. A two channel system capable of recording data from two beam current monitors has been developed, is currently in use, and is discussed below. The development of a cost-effective method of extending this system to more than two channels and integrating of these measurements into an accelerator control system is the main focus of this report. Data from these current monitors is digitized, processed, and stored by a digital data acquisition system. Limitations and drawbacks with the currently deployed digital data acquisition system have been identified as have been potential solutions, or at least improvements, to these problems. This report will discuss and document the efforts we've made in improving the flexibility and lowering the cost of the data acquisition system while maintaining the minimum requirements.

  2. Multiple facets of cAMP signalling and physiological impact : cAMP compartmentalization in the lung

    NARCIS (Netherlands)

    Oldenburger, Anouk; Maarsingh, Harm; Schmidt, Martina

    2012-01-01

    Therapies involving elevation of the endogenous suppressor cyclic AMP (cAMP) are currently used in the treatment of several chronic inflammatory disorders, including chronic obstructive pulmonary disease (COPD). Characteristics of COPD are airway obstruction, airway inflammation and airway remodelli

  3. Beyond PICO: the SPIDER tool for qualitative evidence synthesis.

    Science.gov (United States)

    Cooke, Alison; Smith, Debbie; Booth, Andrew

    2012-10-01

    Standardized systematic search strategies facilitate rigor in research. Current search tools focus on retrieval of quantitative research. In this article we address issues relating to using existing search strategy tools, most typically the PICO (Population, Intervention, Comparison, Outcome) formulation for defining key elements of a review question, when searching for qualitative and mixed methods research studies. An alternative search strategy tool for qualitative/mixed methods research is outlined: SPIDER (Sample, Phenomenon of Interest, Design, Evaluation, Research type). We used both the SPIDER and PICO search strategy tools with a qualitative research question. We have used the SPIDER tool to advance thinking beyond PICO in its suitable application to qualitative and mixed methods research. However, we have highlighted once more the need for improved indexing of qualitative articles in databases. To constitute a viable alternative to PICO, SPIDER needs to be refined and tested on a wider range of topics.

  4. A detector based on silica fibers for ion beam monitoring in a wide current range

    Science.gov (United States)

    Auger, M.; Braccini, S.; Carzaniga, T. S.; Ereditato, A.; Nesteruk, K. P.; Scampoli, P.

    2016-03-01

    A detector based on doped silica and optical fibers was developed to monitor the profile of particle accelerator beams of intensity ranging from 1 pA to tens of μA. Scintillation light produced in a fiber moving across the beam is measured, giving information on its position, shape and intensity. The detector was tested with a continuous proton beam at the 18 MeV Bern medical cyclotron used for radioisotope production and multi-disciplinary research. For currents from 1 pA to 20 μA, Ce3+ and Sb3+ doped silica fibers were used as sensors. Read-out systems based on photodiodes, photomultipliers and solid state photomultipliers were employed. Profiles down to the pA range were measured with this method for the first time. For currents ranging from 1 pA to 3 μA, the integral of the profile was found to be linear with respect to the beam current, which can be measured by this detector with an accuracy of ~1%. The profile was determined with a spatial resolution of 0.25 mm. For currents ranging from 5 μA to 20 μA, thermal effects affect light yield and transmission, causing distortions of the profile and limitations in monitoring capabilities. For currents higher than ~1 μA, non-doped optical fibers for both producing and transporting scintillation light were also successfully employed.

  5. Magnetic focusing of cold atomic beam with a 2D array of current-carrying wires

    Institute of Scientific and Technical Information of China (English)

    Yang Liu; Min Yun; Jianping Yin

    2006-01-01

    @@ A new scheme to realize a two-dimensional (2D) array of magnetic micro-lenses for a cold atomic beam,formed by an array of square current-carrying wires,is proposed.We calculate the spatial distributions of the magnetic fields from the array of current-carrying wires and the magnetic focusing potential for cold rubidium atoms,and study the dynamic focusing processes of cold atoms passing through the magnetic micro-lens array and its focusing properties by using Monte-Carlo simulations and trajectory tracing method.The result shows that the proposed micro-lens array can be used to focus effectively a cold atomic beam,even to load ultracold atoms or a BEC sample into a 2D optical lattice formed by blue detuned hollow beams.

  6. Low energy high current pulsed electron beam treatment for improving surface microstructure and properties

    Energy Technology Data Exchange (ETDEWEB)

    Wu, J; Allain-Bonasso, N; Zhang, X D; Hao, S Z; Grosdider, T; Dong, C [Laboratoire d' Etude des Textures et Applications aux Materiaux (LETAM, UMR-CNRS 3143), Universite Paul Verlaine-Metz, Ile du Saulcy, 57045 Metz (France); Zou, J X, E-mail: jiang.wu@univ-metz.fr, E-mail: thierry.grosdidier@univ-metz.fr [National Engineering Research Center of Light Alloy Net Forming, Shanghai Jiao Tong University, Shanghai 200240 (China)

    2010-06-15

    Low energy high current pulsed electron beam (LEHCPEB) is a fairly new technique for surface modifications authorizing improvement in wear and corrosion properties as well as texture changes and hardening. This contribution highlights some microstructure modifications encountered at the surface of HCPEB treated steels and bulk metallic glasses taking into account the effects of surface melting and the effects of the induced stress.

  7. Upward electron beams measured by DE-1 - A primary source of dayside region-1 Birkeland currents

    Science.gov (United States)

    Burch, J. L.; Reiff, P. H.; Sugiura, M.

    1983-01-01

    Measurements made by the High Altitude Plasma Instrument on DE-1 have shown that intense upward electron beams with energies from about 20 eV to about 200 eV are a common feature of the region just equatorward of the morning-side polar cusp. Computations of the currents carried by these beams and by the precipitating cusp electrons show excellent agreement with the simultaneous DE-1 magnetometer measurements for both upward and downward Birkeland currents. The data indicate that cold ionospheric electrons, which carry the downward region-1 Birkeland currents on the morning side, are accelerated upward by potential drops of a few tens of eV at altitudes of several thousand kilometers. This acceleration process allows spacecraft above those altitudes to measure routinely the charge carriers of both downward and upward current systems.

  8. The current status of cone beam computed tomography imaging in orthodontics

    OpenAIRE

    S. Kapila; Conley, R S; Harrell, W E

    2011-01-01

    Cone beam CT (CBCT) has become an increasingly important source of three dimensional (3D) volumetric data in clinical orthodontics since its introduction into dentistry in 1998. The purpose of this manuscript is to highlight the current understanding of, and evidence for, the clinical use of CBCT in orthodontics, and to review the findings to answer clinically relevant questions. Currently available information from studies using CBCT can be organized into five broad categories: 1, the assess...

  9. Search for lepton number violating charged current processes with neutrino beams

    Energy Technology Data Exchange (ETDEWEB)

    Kanemura, Shinya, E-mail: kanemu@sci.u-toyama.ac.jp [Department of Physics, University of Toyama, 3190 Gofuku, Toyama 930-8555 (Japan); Kuno, Yoshitaka, E-mail: kuno@phys.sci.osaka-u.ac.jp [Department of Physics, Osaka University, Toyonaka, Osaka 560-0043 (Japan); Ota, Toshihiko, E-mail: toshi@mppmu.mpg.de [Max-Planck-Institut für Physik (Werner-Heisenberg-Institut), Föhringer Ring 6, 80805 München (Germany)

    2013-02-26

    We propose a novel idea on measurements to understand which physics mechanism is responsible for the origin of a small neutrino mass, by searching for the processes of lepton number violating charged current interaction with incident of a neutrino beam. It turns out that only the proposed measurements could provide a potential to discriminate the mechanisms, in particular the ones called loop-induced mechanisms of neutrino mass generation, from the others. The expected rates of these processes based on some theoretical assumptions are estimated. They are found to be sizable so that detection of such processes could be achievable at near detectors in future highly intense neutrino-beam facilities.

  10. Application of ESPRIT in Broad Beam HF Ground Wave Radar Sea Surface Current Mapping

    Institute of Scientific and Technical Information of China (English)

    Liu Dan-hong; Wu Xiong-bin; Wen Bi-yang; Cheng Feng

    2004-01-01

    HF surface wave radar system OSMAR2000 is a broad-beam sea-state detecting radar. ESPRIT (Estimation of Signal Parameters via Rotational Invariance Technique) algorithm is proposed to apply in DOA (direction of arrival) determination of sea echoes. The algorithm of ESPRIT is briefly introduced first. Then discussions are made on the technique for application in the OSMAR2000 framework. Numerical simulation results are presented to demonstrate the feasibility of radial current mapping based on this method. The algorithm manifests significant performance and computational advantages compared with that of MUSIC. Data acquired by OSMAR2000 are processed to give radial current map and the synthesized vector currents are compared with the in-situ measurement with traditional means. The results show the validity of ESPRIT application in DOA determination for broad-beam radar.

  11. A compact x-ray beam intensity monitor using gas amplified sample current measurement

    Science.gov (United States)

    Hayakawa, Shinjiro; Kobayashi, Kazuo; Gohshi, Yohichi

    2000-01-01

    Development of a compact beam intensity monitor using gas amplified sample current measurement is described. The monitor can be a powerful tool for x-ray spectroscopy and microscopy when the beam is defined by a small pinhole or slits and when the workspace around the sample is limited. The thickness of the monitor is as small as approximately 3 mm, and the dimension is 10 mm square. The photon flux is monitored by measuring x-ray excited current from an Al foil under atmospheric conditions. Emitted electrons from the Al foil can ionize surrounding air molecules, and the gas amplified current can be measured with the use of a biased grid that prevents created ion pairs from recombination.

  12. Discharge current and current of supershort avalanche E-beam at volume nanosecond discharge in non-uniform electric field

    Science.gov (United States)

    Tarasenko, Victor F.; Rybka, Dmitrii V.; Baksht, Evgenii H.; Kostyrya, Igor'D.; Lomaev, Mikhail I.

    2008-01-01

    The gas diode current-voltage characteristics at the voltage pulses applied from the RADAN and SM-3NS pulsers, and generation of an supershort avalanche electron beam (SAEB) have been studied experimentally in an inhomogeneous electric field upon a nanosecond breakdown in an air gap at atmospheric pressure. Displacement currents with amplitude over 1 kA have been observed and monitored. It is shown that the displacement current amplitude gets increased due to movement of the dense plasma front and charging of a "capacitor" formed between plasma and anode. The SAEB generation time relatively to the discharge current pulses and the gap voltage were determined in the experiments. It is shown that the SAEB current maximum at the pulser voltages of hundreds kV is registered on the discharge current pulse front, before the discharge current peak of the gas diode capacitance, and the delay time of these peaks is determined by the value of an interelectrode spacing. The delay time in case of a gap of 16 mm and air breakdown at atmospheric pressure was ~100 ps, and in case of 10 mm it was less than 50 ps.

  13. Comparison of Parmela and MAFIA Simulations of Beam Dynamics in High Current Photoinjector

    CERN Document Server

    Kurennoy, Sergey S

    2004-01-01

    A high-current RF photoinjector producing low-emittance electron beam is an important technology for high-power CW FEL. LANL-AES team designed a 2.5-cell, pi-mode, 700-MHz normal-conducting RF photoinjector with magnetic emittance compensation. With the electric field gradients of 7, 7, and 5 MV/m in the three subsequent cells, the photoinjector will produce a 2.5-MeV electron beam with 3-nC charge per bunch and the transverse rms emittance 7 mm-mrad. Beam dynamics in the photoinjector has been modeled in details. In addition to the usual approach, with fields calculated by Superfish-Poisson and beam simulations performed by Parmela, we also used MAFIA group of codes, both to calculate cavity fields and to model beam dynamics with its particle-in-cell module TS. The second way naturally includes wake-field effects into consideration. The simulation results and comparison between two approaches will be presented.

  14. Simulations and experiments of intense ion beam current density compression in space and timea)

    Science.gov (United States)

    Sefkow, A. B.; Davidson, R. C.; Gilson, E. P.; Kaganovich, I. D.; Anders, A.; Coleman, J. E.; Leitner, M.; Lidia, S. M.; Roy, P. K.; Seidl, P. A.; Waldron, W. L.; Yu, S. S.; Welch, D. R.

    2009-05-01

    The Heavy Ion Fusion Science Virtual National Laboratory has achieved 60-fold longitudinal pulse compression of ion beams on the Neutralized Drift Compression Experiment (NDCX) [P. K. Roy et al., Phys. Rev. Lett. 95, 234801 (2005)]. To focus a space-charge-dominated charge bunch to sufficiently high intensities for ion-beam-heated warm dense matter and inertial fusion energy studies, simultaneous transverse and longitudinal compression to a coincident focal plane is required. Optimizing the compression under the appropriate constraints can deliver higher intensity per unit length of accelerator to the target, thereby facilitating the creation of more compact and cost-effective ion beam drivers. The experiments utilized a drift region filled with high-density plasma in order to neutralize the space charge and current of an ˜300 keV K+ beam and have separately achieved transverse and longitudinal focusing to a radius 2 MeV) ion beam user-facility for warm dense matter and inertial fusion energy-relevant target physics experiments.

  15. Detection of cyclic di-AMP using a competitive ELISA with a unique pneumococcal cyclic di-AMP binding protein

    Science.gov (United States)

    Underwood, Adam J.; Zhang, Yang; Metzger, Dennis W.; Bai, Guangchun

    2014-01-01

    Cyclic di-AMP (c-di-AMP) is a signaling molecule that has been shown to play important roles in bacterial physiology and infections. Currently, c-di-AMP detection and quantification relies mostly on the use of high-performance liquid chromatography (HPLC) or liquid chromatography-mass spectrometry (LC-MS). In this study, a competitive enzyme-linked immunosorbent assay (ELISA) for the quantification of c-di-AMP was developed, which utilizes a novel pneumococcal c-di-AMP binding protein (CabP) and a newly commercialized c-di-AMP derivative. With this new method, c-di-AMP concentrations in biological samples can be quickly and accurately quantified. Furthermore, this assay is much more efficient than current methods as it requires less overall cost and training while processing many samples at once. Therefore, this assay can be extensively used in research into c-di-AMP signaling. PMID:25239824

  16. Proceedings of the 1979 workshop on beam current limitations in storage rings, July 16-27, 1979

    Energy Technology Data Exchange (ETDEWEB)

    Pellegrini, C. (ed.)

    1979-01-01

    The Workshop on Beam Current Limitations in Storage Rings was held at Brookhaven National Laboratory from July 16 to 27, 1979. The purpose of this Workshop was to discuss the physical mechanisms limiting the beam current or current density in accelerators or storage rings. Many of these machines are now being built or planned for a variety of applications, such as colliding beam experiments, synchrotron light production, heavy ion beams. This diversity was reflected in the Workshop and in the papers which have been contributed to these Proceedings. The twenty-one papers from the workshop were incorporated individually in the data base. (GHT)

  17. Test beam results of a heavily irradiated Current Injected Detector (CID)

    CERN Document Server

    Harkonen, J; Tuominen, E; Moilanen, H; Maenpaa, T; Verbitskaya, E; Eremin, V; Czellar, S; Dierlamm, A; Tuovinen, E; Lampen, T; Frey, M; Li, Z; Luukka, P

    2010-01-01

    A heavily irradiated (3 x 10(15) 1 MeV n(eq)/cm(2)) Current Injected Detector (CID) was tested with 225 GeV muon beam at CERN H2 beam line. In the CID concept the current is limited by the space charge. The injected carriers will be trapped by the deep levels and this induces a stable electric field through the entire bulk regardless of the irradiation fluence the detector has been exposed to. The steady-state density of the trapped charge is defined by the balance between the trapping and the emission rates of charge carriers (detrapping). Thus, the amount of charge injection needed for the electric field stabilization depends on the temperature. AC-coupled 16 cm(2) detector was processed on high resistivity n-type magnetic Czochralski silicon, and it had 768 strips, 50 mu m pitch, 10 mu m strip width and 3.9 cm strip length. The beam test was carried out using a silicon beam telescope that is based on the CMS detector readout prototype components, APV25 readout chips, and eight strip sensors made by Hamamat...

  18. Saturation current and collection efficiency for ionization chambers in pulsed beams.

    Science.gov (United States)

    DeBlois, F; Zankowski, C; Podgorsak, E B

    2000-05-01

    Saturation currents and collection efficiencies in ionization chambers exposed to pulsed megavoltage photon and electron beams are determined assuming a linear relationship between 1/I and 1/V in the extreme near-saturation region, with I and V the chamber current and polarizing voltage, respectively. Careful measurements of chamber current against polarizing voltage in the extreme near-saturation region reveal a current rising faster than that predicted by the linear relationship. This excess current combined with conventional "two-voltage" technique for determination of collection efficiency may result in an up to 0.7% overestimate of the saturation current for standard radiation field sizes of 10X10 cm2. The measured excess current is attributed to charge multiplication in the chamber air volume and to radiation-induced conductivity in the stem of the chamber (stem effect). These effects may be accounted for by an exponential term used in conjunction with Boag's equation for collection efficiency in pulsed beams. The semiempirical model follows the experimental data well and accounts for both the charge recombination as well as for the charge multiplication effects and the chamber stem effect.

  19. Dosimetric response for crystalline and nanostructured aluminium oxide to a high-current pulse electron beam.

    Science.gov (United States)

    Nikiforov, S V; Kortov, V S

    2014-11-01

    The main thermoluminescent (TL) and dosimetric properties of the detectors based on anion-defective crystalline and nanostructured aluminium oxide after exposure to a high-current pulse electron beam are studied. TL peaks associated with deep-trapping centres are registered. It is shown that the use of deep-trap TL at 200-600°С allows registering absorbed doses up to 750 kGy for single-crystalline detectors and those up to 6 kGy for nanostructured ones. A wide range of the doses registered, high reproducibility of the TL signal and low fading contribute to a possibility of using single-crystalline and nanostructured aluminium oxide for the dosimetry of high-current pulse electron beams.

  20. Charged current disappearance measurements in the NuMI off-axis beam

    Energy Technology Data Exchange (ETDEWEB)

    R. H. Bernstein

    2003-09-25

    This article studies the potential of combining charged-current disappearance measurements of {nu}{sub {mu}} {yields} {nu}{sub {tau}} from MINOS and an off-axis beam. The author finds that the error on {Delta}m{sup 2} from a 100 kt-yr off-axis measurement is a few percent of itself. Further, the author found little improvement to an off-axis measurement by combining it with MINOS.

  1. Open-loop correction for an eddy current dominated beam-switching magnet

    Science.gov (United States)

    Koseki, K.; Nakayama, H.; Tawada, M.

    2014-04-01

    A beam-switching magnet and the pulsed power supply it requires have been developed for the Japan Proton Accelerator Research Complex. To switch bunched proton beams, the dipole magnetic field must reach its maximum value within 40 ms. In addition, the field flatness should be less than 5 × 10-4 to guide each bunched beam to the designed orbit. From a magnetic field measurement by using a long search coil, it was found that an eddy current in the thick endplates and laminated core disturbs the rise of the magnetic field. The eddy current also deteriorates the field flatness over the required flat-top period. The measured field flatness was 5 × 10-3. By using a double-exponential equation to approximate the measured magnetic field, a compensation pattern for the eddy current was calculated. The integrated magnetic field was measured while using the newly developed open-loop compensation system. A field flatness of less than 5 × 10-4, which is an acceptable value, was achieved.

  2. Open-loop correction for an eddy current dominated beam-switching magnet

    Energy Technology Data Exchange (ETDEWEB)

    Koseki, K., E-mail: kunio.koseki@kek.jp; Nakayama, H.; Tawada, M. [High Energy Accelerator Research Organization, 1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan)

    2014-04-15

    A beam-switching magnet and the pulsed power supply it requires have been developed for the Japan Proton Accelerator Research Complex. To switch bunched proton beams, the dipole magnetic field must reach its maximum value within 40 ms. In addition, the field flatness should be less than 5 × 10{sup −4} to guide each bunched beam to the designed orbit. From a magnetic field measurement by using a long search coil, it was found that an eddy current in the thick endplates and laminated core disturbs the rise of the magnetic field. The eddy current also deteriorates the field flatness over the required flat-top period. The measured field flatness was 5 × 10{sup −3}. By using a double-exponential equation to approximate the measured magnetic field, a compensation pattern for the eddy current was calculated. The integrated magnetic field was measured while using the newly developed open-loop compensation system. A field flatness of less than 5 × 10{sup −4}, which is an acceptable value, was achieved.

  3. Review of the neutral-beam current requirements for the Mirror Fusion Test Facility (MFTF)

    Energy Technology Data Exchange (ETDEWEB)

    Porter, G.D.; Coensgen, F.H.; Devoto, R.S.; Molvik, A.W.; Osher, J.F.; Shearer, J.W.; Thomassen, K.I.

    1978-08-04

    The techniques used to evaluate the beam-current requirements for MFTF are similar to those in previous studies but incorporate some improvements. In particular, we have enlarged the radial code BUILDUP to allow for a smaller radial grid and to improve the numerical accuracy; we have also improved the model of the atomic physics processes and the particle-equilibrium calculations. Also, a model of plasma containment that conserves energy as well as particles but does not include any effect of the expected drift-cyclotron loss-cone (DCLC) turbulence has been incorporated into the previous studies. We show that the DCLC turbulence increases the average ion energy and decreases the particle confinement time. Because these effects cancel to first order, the beam-current requirements are independent of the turbulence. We find that 24 of the present LBL source modules would sustain a plasma with an average beta of 0.46. This figure is within 10% of the MFTF goal and is within our calculational accuracies. We further show that the beam-current requirements for the large-diameter plasma are consistent with those of experiments to study the buildup of a field-reversed plasma.

  4. High-power Čerenkov microwave oscillators utilizing High-Current nanosecond Electron beams

    Science.gov (United States)

    Korovin, S. D.; Polevin, S. D.; Rostov, V. V.

    1996-12-01

    A short review is given of results obtained at the Institute of High-Current Electronics of the Siberian Branch of the Russian Academy of Sciences on generating high-power microwave radiation. Most of the research was devoted to a study of stimulated Čerenkov radiation from relativistic electron beams. It is shown that the efficiency of a relativistic 3-cm backward wave tube with a nonuniform coupling resistance can reach 35%. High-frequency radiation was discovered in the emission spectrum of the Čerenkov oscillators and it was shown that the nature of the radiation was associated with the stimulated scattering of low-frequency radiation by the relativistic electrons. Radiation with a power of 500 MW was obtained in the 8-mm wavelength range using a two-beam Čerenkov oscillator. High-current pulse-periodic nanosecond accelerators with a charging device utilizing a Tesla transformer were used in the experiments. The possibility was demonstrated of generating high-power microwave radiation with a pulse-repetition frequency of up to 100 Hz. An average power of ˜500 W was achieved from the relativistic oscillators. A relativistic backward wave tube with a high-current electron beam was used to make a prototype nanosecond radar device. Some of the results presented were obtained jointly with the Russian Academy of Sciences Institute of Applied Physics. Questions concerning multiwave Čerenkov interaction are not considered in this paper.

  5. Experiments on current-driven three-dimensional ion sound turbulence. I - Return-current limited electron beam injection. II - Wave dynamics

    Science.gov (United States)

    Stenzel, R. L.

    1978-01-01

    Pulsed electron beam injection into a weakly collisional magnetized background plasma is investigated experimentally; properties of the electron beam and background plasma, as well as the low-frequency instabilities and wave dynamics, are discussed. The current of the injected beam closes via a field-aligned return current of background electrons. Through study of the frequency and wavenumber distribution, together with the electron distribution function, the low-frequency instabilities associated with the pulsed injection are identified as ion acoustic waves driven unstable by the return current. The frequency cut-off of the instabilities predicted from renormalized plasma turbulence theory, has been verified experimentally.

  6. Numerical simulation of the processes of small-diameter high-current electron beam shaping and injection

    CERN Document Server

    Gordeev, V S; Myskov, G A

    2001-01-01

    With the aid of BEAM 25 program there was carried out the numerical simulation of the non-stationary process of shaping a small-diameter (<= 20mm) high-current hollow electron beam in a diode with magnetic insulation,as well as of the process of beam injection into the accelerating LIA track. The diode configuration for the purpose of eliminating the leakage of electron flux to the anode surface was update. Presented are the results of calculation of the injected beam characteristics (amplitude-time parameters of a current pulse, space-angle distributions of electrons etc.) depending on diode geometric parameters.

  7. Coherent Effects of High Current Beam in Project-X Linac

    Energy Technology Data Exchange (ETDEWEB)

    Sukhanov, Alexander; Yakovlev, Vyacheslav; Gonin, Ivan; Khabiboulline, Timergali; Lunin, Andrei; Saini, Arun; Solyak, Nikolay; Vostrikov, Alexander

    2013-04-01

    Resonance excitation of longitudinal high order modes in superconducting RF structures of Project-X continuous wave linac is studied. We analyze regimes of operation of the linac with high beam current, which can be used to provide an intense muon source for the future Neutrino Factory or Muon Collider, and also important for the Accelerator-Driven Subcritical systems. We calculate power loss and associated heat load to the cryogenic system. Longitudinal emittance growth is estimated. We consider an alternative design of the elliptical cavity for the high energy part of the linac, which is more suitable for high current operation.

  8. Amplification of current density modulation in a FEL with an infinite electron beam

    Energy Technology Data Exchange (ETDEWEB)

    Wang, G.; Litvinenko, V.N.; Webb, S.D.

    2011-03-28

    We show that the paraxial field equation for a free electron laser (FEL) in an infinitely wide electron beam with {kappa}-2 energy distribution can be reduced to a fourth ordinary differential equation (ODE). Its solution for arbitrary initial phase space density modulation has been derived in the wave-vector domain. For initial current modulation with Gaussian profile, close form solutions are obtained in space-time domain. In developing an analytical model for a FEL-based coherent electron cooling system, an infinite electron beam has been assumed for the modulation and correction processes. While the assumption has its limitation, it allows for an analytical close form solution to be obtained, which is essential for investigating the underlying scaling law, benchmarking the simulation codes and understanding the fundamental physics. 1D theory was previously applied to model a CeC FEL amplifier. However, the theory ignores diffraction effects and does not provide the transverse profile of the amplified electron density modulation. On the other hand, 3D theories developed for a finite electron beam usually have solutions expanded over infinite number of modes determined by the specific transverse boundary conditions. Unless the mode with the largest growth rate substantially dominates other modes, both evaluation and extracting scaling laws can be complicated. Furthermore, it is also preferable to have an analytical FEL model with assumptions consistent with the other two sections of a CeC system. Recently, we developed the FEL theory in an infinitely wide electron beam with {kappa}-1 (Lorentzian) energy distribution. Close form solutions have been obtained for the amplified current modulation initiated by an external electric field with various spatial-profiles. In this work, we extend the theory into {kappa}-2 energy distribution and study the evolution of current density induced by an initial density modulation.

  9. Determination of the ReA Electron Beam Ion Trap electron beam radius and current density with an X-ray pinhole camera

    Energy Technology Data Exchange (ETDEWEB)

    Baumann, Thomas M., E-mail: baumannt@nscl.msu.edu; Lapierre, Alain, E-mail: lapierre@nscl.msu.edu; Kittimanapun, Kritsada; Schwarz, Stefan; Leitner, Daniela; Bollen, Georg [National Superconducting Cyclotron Laboratory (NSCL), Michigan State University (MSU), 640 S. Shaw Lane, East Lansing, Michigan, 48824 (United States)

    2014-07-15

    The Electron Beam Ion Trap (EBIT) of the National Superconducting Cyclotron Laboratory at Michigan State University is used as a charge booster and injector for the currently commissioned rare isotope re-accelerator facility ReA. This EBIT charge breeder is equipped with a unique superconducting magnet configuration, a combination of a solenoid and a pair of Helmholtz coils, allowing for a direct observation of the ion cloud while maintaining the advantages of a long ion trapping region. The current density of its electron beam is a key factor for efficient capture and fast charge breeding of continuously injected, short-lived isotope beams. It depends on the radius of the magnetically compressed electron beam. This radius is measured by imaging the highly charged ion cloud trapped within the electron beam with a pinhole camera, which is sensitive to X-rays emitted by the ions with photon energies between 2 keV and 10 keV. The 80%-radius of a cylindrical 800 mA electron beam with an energy of 15 keV is determined to be r{sub 80%}=(212±19)μm in a 4 T magnetic field. From this, a current density of j = (454 ± 83)A/cm{sup 2} is derived. These results are in good agreement with electron beam trajectory simulations performed with TriComp and serve as a test for future electron gun design developments.

  10. Current profile redistribution driven by neutral beam injection in a reversed-field pinch

    Science.gov (United States)

    Parke, E.; Anderson, J. K.; Brower, D. L.; Den Hartog, D. J.; Ding, W. X.; Johnson, C. A.; Lin, L.

    2016-05-01

    Neutral beam injection in reversed-field pinch (RFP) plasmas on the Madison Symmetric Torus [Dexter et al., Fusion Sci. Technol. 19, 131 (1991)] drives current redistribution with increased on-axis current density but negligible net current drive. Internal fluctuations correlated with tearing modes are observed on multiple diagnostics; the behavior of tearing mode correlated structures is consistent with flattening of the safety factor profile. The first application of a parametrized model for island flattening to temperature fluctuations in an RFP allows inferrence of rational surface locations for multiple tearing modes. The m = 1, n = 6 mode is observed to shift inward by 1.1 ± 0.6 cm with neutral beam injection. Tearing mode rational surface measurements provide a strong constraint for equilibrium reconstruction, with an estimated reduction of q0 by 5% and an increase in on-axis current density of 8% ± 5%. The inferred on-axis current drive is consistent with estimates of fast ion density using TRANSP [Goldston et al., J. Comput. Phys. 43, 61 (1981)].

  11. Current profile redistribution driven by neutral beam injection in a reversed-field pinch

    Energy Technology Data Exchange (ETDEWEB)

    Parke, E. [Department of Physics and Astronomy, University of California Los Angeles 475 Portola Plaza, Los Angeles, California 90095 (United States); Department of Physics, University of Wisconsin-Madison 1150 University Ave., Madison, Wisconsin 53706 (United States); Anderson, J. K.; Den Hartog, D. J. [Department of Physics, University of Wisconsin-Madison 1150 University Ave., Madison, Wisconsin 53706 (United States); Brower, D. L.; Ding, W. X.; Lin, L. [Department of Physics and Astronomy, University of California Los Angeles 475 Portola Plaza, Los Angeles, California 90095 (United States); Johnson, C. A. [Department of Physics, University of Wisconsin-Madison 1150 University Ave., Madison, Wisconsin 53706 (United States); Department of Physics, Auburn University 206 Allison Laboratory, Auburn, Alabama 36849 (United States)

    2016-05-15

    Neutral beam injection in reversed-field pinch (RFP) plasmas on the Madison Symmetric Torus [Dexter et al., Fusion Sci. Technol. 19, 131 (1991)] drives current redistribution with increased on-axis current density but negligible net current drive. Internal fluctuations correlated with tearing modes are observed on multiple diagnostics; the behavior of tearing mode correlated structures is consistent with flattening of the safety factor profile. The first application of a parametrized model for island flattening to temperature fluctuations in an RFP allows inferrence of rational surface locations for multiple tearing modes. The m = 1, n = 6 mode is observed to shift inward by 1.1 ± 0.6 cm with neutral beam injection. Tearing mode rational surface measurements provide a strong constraint for equilibrium reconstruction, with an estimated reduction of q{sub 0} by 5% and an increase in on-axis current density of 8% ± 5%. The inferred on-axis current drive is consistent with estimates of fast ion density using TRANSP [Goldston et al., J. Comput. Phys. 43, 61 (1981)].

  12. Radiation induced currents in parallel plate ionization chambers: measurement and Monte Carlo simulation for megavoltage photon and electron beams.

    Science.gov (United States)

    Abdel-Rahman, Wamied; Seuntjens, Jan P; Verhaegen, Frank; Podgorsak, Ervin B

    2006-09-01

    Polarity effects in ionization chambers are caused by a radiation induced current, also known as Compton current, which arises as a charge imbalance due to charge deposition in electrodes of ionization chambers. We used a phantom-embedded extrapolation chamber (PEEC) for measurements of Compton current in megavoltage photon and electron beams. Electron contamination of photon beams and photon contamination of electron beams have a negligible effect on the measured Compton current. To allow for a theoretical understanding of the Compton current produced in the PEEC effect we carried out Monte Carlo calculations with a modified user code, the COMPTON/ EGSnrc. The Monte Carlo calculated COMPTON currents agree well with measured data for both photon and electron beams; the calculated polarity correction factors, on the other hand, do not agree with measurement results. The conclusions reached for the PEEC can be extended to parallel-plate ionization chambers in general.

  13. Development of heating device / development of the high current ion source for neutral beam injection

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Heon Ju; Lee, Dong Gyu; Lee, Kyong Jin; Ko Tae Kyong [Cheju National Univ., Cheju (Korea)

    1998-08-01

    The design and fabrication of a high current ion source for NBI was carried out. The scale of an ion source was reduced for mock-up test. To develop the high current ion source with the high operational stability and the long lifetime, the parameters including an arc current, gas pressure and extraction voltage should be optimized. If fabricated ion source would be tested, its parameters could be optimized experimentally. Through the optimization of the ion source parameter, the core technology for NBI is established and the experiment of current drive in the fusion device can be performed. This technology also can be applied to the ion beam technology in the field of new material synthesis and semiconductor industry. 24 refs., 22 figs., 13 tabs. (Author)

  14. Switching processes in TGS crystals irradiated by high-current electron beam

    CERN Document Server

    Efimov, V V; Klevtsova, E A; Tyutyunnikov, S I

    2002-01-01

    The relaxation processes study of the dielectric permittivity epsilon during commutation of the external electric field in triglycine sulphate (NH sub 2 CH sub 2 COOH) sub 3 centre dot H sub 2 SO sub 4 (TGS) single crystal plates before and after irradiation by a high-current pulsed electron beam with different doses at various temperatures is presented. The parameters of the electron beam produced by the accelerator facility as a source were: energy E = 250 keV, current density I = 1000 A/cm sup 2 , fluence F = 15 J/cm sup 2 , pulse duration tau = 300 ns, beam density 5 centre dot sup 1 5 electrons/cm sup 2 per pulse. It was shown that the dependences of epsilon (t) are described by the Kohlrausch law: epsilon (t) approx exp (-t/tau) supalpha, where alpha is the average relaxation time of the all volume samples, 0 < alpha <1. Besides, it was found that switching processes in the irradiated crystals were much more intensive than those in the non-irradiated ones. The relaxation times decrease with rising...

  15. Development of a universal serial bus interface circuit for ion beam current integrators.

    Science.gov (United States)

    Suresh, K; Panigrahi, B K; Nair, K G M

    2007-08-01

    A universal serial bus (USB) interface circuit has been developed to enable easy interfacing of commercial as well as custom-built ion beam current integrators to personal computer (PC) based automated experimental setups. Built using the popular PIC16F877A reduced instruction set computer and a USB-universal asynchronous receiver-transmitter/first in, first out controller, DLP2232, this USB interface circuit virtually emulates the ion beam current integrators on a host PC and uses USB 2.0 protocol to implement high speed bidirectional data transfer. Using this interface, many tedious and labor intensive ion beam irradiation and characterization experiments can be redesigned into PC based automated ones with advantages of improved accuracy, rapidity, and ease of use and control. This interface circuit was successfully used in carrying out online in situ resistivity measurement of 70 keV O(+) ion irradiated tin thin films using four probe method. In situ electrical resistance measurement showed the formation of SnO(2) phase during ion implantation.

  16. Dark currents and their effect on the primary beam in an X-band linac

    Directory of Open Access Journals (Sweden)

    Karl L. F. Bane

    2005-06-01

    Full Text Available We numerically study properties of primary dark currents in an X-band accelerating structure. For the H60VG3 structure considered for the Next Linear Collider (NLC we first perform a fairly complete (with some approximations calculation of dark-current trajectories. These results are used to study properties of the dark current leaving the structure. For example, at accelerating gradient of 65  MV/m, considering two very different assumptions about dark-current emission around the irises, we find that the fraction of emitted current leaving the structure to be a consistent ∼1%. Considering that ∼1  mA outgoing dark current is seen in measurement, this implies that ∼100  mA (or 10 pC per period is emitted within the structure itself. Using the formalism of the Liénard-Wiechert potentials, we then perform a systematic calculation of the transverse kick of dark currents on a primary linac bunch. The result is ∼1   V kick per mA (or per 0.1  pC per period dark current emitted from an iris. For an entire structure we estimate the total kick on a primary bunch to be ∼15   V. For the NLC linac this translates to a ratio of (final vertical beam offset to beam size of about 0.2. However, with the assumptions that needed to be made—particularly the number of emitters and their distribution within a structure—the accuracy of this result may be limited to the order of magnitude.

  17. AMP is an adenosine A1 receptor agonist.

    Science.gov (United States)

    Rittiner, Joseph E; Korboukh, Ilia; Hull-Ryde, Emily A; Jin, Jian; Janzen, William P; Frye, Stephen V; Zylka, Mark J

    2012-02-17

    Numerous receptors for ATP, ADP, and adenosine exist; however, it is currently unknown whether a receptor for the related nucleotide adenosine 5'-monophosphate (AMP) exists. Using a novel cell-based assay to visualize adenosine receptor activation in real time, we found that AMP and a non-hydrolyzable AMP analog (deoxyadenosine 5'-monophosphonate, ACP) directly activated the adenosine A(1) receptor (A(1)R). In contrast, AMP only activated the adenosine A(2B) receptor (A(2B)R) after hydrolysis to adenosine by ecto-5'-nucleotidase (NT5E, CD73) or prostatic acid phosphatase (PAP, ACPP). Adenosine and AMP were equipotent human A(1)R agonists in our real-time assay and in a cAMP accumulation assay. ACP also depressed cAMP levels in mouse cortical neurons through activation of endogenous A(1)R. Non-selective purinergic receptor antagonists (pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid and suramin) did not block adenosine- or AMP-evoked activation. Moreover, mutation of His-251 in the human A(1)R ligand binding pocket reduced AMP potency without affecting adenosine potency. In contrast, mutation of a different binding pocket residue (His-278) eliminated responses to AMP and to adenosine. Taken together, our study indicates that the physiologically relevant nucleotide AMP is a full agonist of A(1)R. In addition, our study suggests that some of the physiological effects of AMP may be direct, and not indirect through ectonucleotidases that hydrolyze this nucleotide to adenosine.

  18. Carta de Giovanni Pico della Mirandola a Gianfrancesco Pico

    OpenAIRE

    Barenstein, Julián

    2016-01-01

    Celebrado por la efusiva prosa de su Oratio de hominis dignitate de 1486,1 Giovanni Pico (1463-1494), conde de Mirandola, “Phoenix del ingenio”, no vale menos por otras de sus obras. Fil: Barenstein, Julián. Universidad de Buenos Aires. Facultad de Filosofía y Letras. Instituto de Filosofía "Dr. Alejandro Korn"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina

  19. Large Area Pico-second Photodetectors (LAPPD) in Liquid Argon

    Science.gov (United States)

    Dharmapalan, Ranjan; Lappd Collaboration

    2015-04-01

    The Large Area Pico-second Photodetector (LAPPD) project has recently produced the first working devices with a small form factor and pico-second timing resolution. A number of current and proposed neutrino and dark matter experiments use liquid argon as a detector medium. A flat photodetector with excellent timing resolution will help with background suppression and improve the overall sensitivity of the experiment. We present the research done and some preliminary results to customize the LAPPD devices to work in a cryogenic environment. Argonne National Laboratory (LDRD) and DOE.

  20. Argumentos Antrópicos

    Science.gov (United States)

    Villas da Rocha, J.F.; Casarejos, F.

    2004-02-01

    A existência de observadores é um fato. Este fato, entretanto, permite que possam ser extraídas informações físicas, astrofísicas e cosmológicas. A realidade da existência de observadores foi elevada por Carter [1] ao nível de um princípio, chamado Princípio Antrópico. Em linhas gerais o Princípio Antrópico afirma que a existência de observadores só é possível dentro de certos parâmetros físicos muito restritos. O Princípio Antrópico é uma fonte de compreensão de fatos observáveis do Universo. Na ausência de explicações provenientes das leis da física, as previsões antrópicas tornam-se importantes fatores de esclarecimento. Além disso, o Princípio Antrópico pode ainda atuar como supressor da necessidade de novas teorias. Foi aliás no quadro de discussões em torno da necessidade de novas teorias que o Princípio Antrópico foi concebido, nomeadamente na discussão em torno dos números muito grandes. Para explicar estes grandes números, Dirac [2] formulou uma hipótese inovadora, a de que a constante gravitacional variaria com o tempo na forma 1 - µ G t . Se aceita, tal relação se constituiria numa revisão das leis da física já estabelecida. Daria origem a uma nova física. Entretanto, com a elaboração do Princípio Antrópico por Dicke [3] e Carter [1] a coincidência de tais grandes números foi compreendida dentro da física tradicional, sem a necessidade de recurso a novas leis.

  1. Suppression of runaway current generation by supersonic molecular beam injection during disruptions on J-TEXT

    Science.gov (United States)

    Huang, D. W.; Chen, Z. Y.; Tong, R. H.; Yan, W.; Wang, S. Y.; Wei, Y. N.; Ma, T. K.; Dai, A. J.; Wang, X. L.; Jiang, Z. H.; Yang, Z. J.; Zhuang, G.; Pan, Y.; J-TEXT Team

    2017-08-01

    The suppression of disruption-generated runaway electrons (REs) by supersonic molecular beam injection (SMBI) has been investigated on the J-TEXT tokamak. Experimental results demonstrate that the hydrogen injected by SMBI during plasma current flattop phase can provoke magnetic perturbations, which increase RE losses rapidly. The effective radial diffusion coefficient of REs due to SMBI is estimated as D r ≈ 16 m2 s-1. Based on this benefit, the SMBI has been used to explore the suppression of disruption-generated REs. In J-TEXT, RE current is created with rapid argon injection by a massive gas injection valve. It is found that hydrogen SMBI before disruption efficiently suppresses the generation of RE current.

  2. A Fast Non Intercepting Linac Electron Beam Position and Current Monitor

    DEFF Research Database (Denmark)

    Hansen, Jørgen-Walther; Wille, Mads

    1982-01-01

    A non-intercepting beam monitor consisting of four detecting loops is used to determine the spatial postion and current of a pulsed beam from an electron linear accelerator. The monitor detects the magnetic field radiated by the substructure of the electron bunches created by the accelerating...... microwave. The detecting loops are interconnected two by two, by means of two coaxial hybrid junctions, the two sets positioned perpendicular to each other. By means of the two signals from the diametrically positioned detecting loops, a good spatial displacement and current monitoring sensitivity...... are achieved by subtracting one signal from the other and adding the two signals, respectively. For displacements below 2 mm from the center axis an average sensitivity of 0.5 mV/mm·mA is measured, whereas displacements more than 2 mm yields 1.3 mV / mm·mA. A sensitivity of 0.2 mV / mA in current monitoring...

  3. Positron annihilation and thermally stimulated current of electron beam irradiated polyetheretherketone

    Energy Technology Data Exchange (ETDEWEB)

    Fujita, Shigetaka; Shinyama, Katsuyoshi; Baba, Makoto [Hachinohe Inst. of Tech., Hachinohe, Aomori (Japan); Suzuki, Takenori

    1997-03-01

    Positron lifetime measurements were applied to electron beam irradiated poly(ether-ether-ketone). The lifetime, {tau}{sub 3}, of the ortho-positronium of unirradiated and 5 MGy irradiated specimen became rapidly longer above about 150degC. {tau}{sub 3} of 50 MGy and 100 MGy irradiated specimen was shorter than that of unirradiated one. Thermally stimulated current (TSC) decreased with increasing the dose before voltage application. In the case of voltage application, a TSC peak appeared and the peak value decreased with increased the dose. The correlation between the results of positron annihilation and TSC was investigated. (author)

  4. PICO DELLA MIRANDOLA Y SAVONAROLA

    Directory of Open Access Journals (Sweden)

    Jorge Velázquez Delgado

    2013-09-01

    Full Text Available En este artículo se aborda la relaciónentre Gerolamo Savonarola y GiovanniPico de la Mirandola, partiendo de labase de la amistad que sostuvieronambos y problematizando la dificultadque se presenta ante dospersonalidades aparentementeirreductibles. En tanto que símbolosemblemáticos del Renacimientoitaliano, su análisis supone un análisisde las ideas y el  ethos del período.

  5. High-resolution velocimetry in energetic tidal currents using a convergent-beam acoustic Doppler profiler

    Energy Technology Data Exchange (ETDEWEB)

    Sellar, Brian [Univ. of Edinburgh, Scotland (United Kingdom); Harding, Samuel F. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Richmond, Marshall C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-07-16

    An array of convergent acoustic Doppler velocimeters has been developed and tested for the high resolution measurement of three-dimensional tidal flow velocities in an energetic tidal site. This configuration has been developed to increase spatial resolution of velocity measurements in comparison to conventional acoustic Doppler profilers (ADPs) which characteristically use diverging acoustic beams emanating from a single instrument. This is achieved using converging acoustic beams with a sample volume at the focal point of 0.03 m3. The array is also able to simultaneously measure three-dimensional velocity components in a profile throughout the water column, and as such is referred to herein as a converging-beam acoustic Doppler profiler (CADP). Mid-depth profiling is achieved through integration of the sensor platform with the operational Alstom 1MW DeepGen-IV Tidal Turbine. This proof-of-concept paper outlines system configuration and comparison to measurements provided by co-installed reference instrumentation. Comparison of CADP to standard ADP velocity measurements reveals a mean difference of 8 mm/s, standard deviation of 18 mm/s, and order-of-magnitude reduction in realizable length-scale. CADP focal point measurements compared to a proximal single-beam reference show peak cross-correlation coefficient of 0.96 over 4.0 s averaging period and a 47% reduction in Doppler noise. The dual functionality of the CADP as a profiling instrument with a high resolution focal point make this configuration a unique and valuable advancement in underwater velocimetry enabling improved turbulence, resource and structural loading quantification and validation of numerical simulations. Alternative modes of operation have been implemented including noise-reducing bi-static sampling. Since waves are simultaneously measured it is expected that derivatives of this system will be a powerful tool in wave-current interaction studies.

  6. Effect of External Magnetic Field on Critical Current for the Onset of Virtual Cathode Oscillations in Relativistic Electron Beams

    CERN Document Server

    Hramov, Alexander E; Morozov, Mikhail; Mushtakov, Alexander

    2008-01-01

    In this Letter we research the space charge limiting current value at which the oscillating virtual cathode is formed in the relativistic electron beam as a function of the external magnetic field guiding the beam electrons. It is shown that the space charge limiting (critical) current decreases with growth of the external magnetic field, and that there is an optimal induction value of the magnetic field at which the critical current for the onset of virtual cathode oscillations in the electron beam is minimum. For the strong external magnetic field the space charge limiting current corresponds to the analytical relation derived under the assumption that the motion of the electron beam is one-dimensional [High Power Microwave Sources. Artech House Microwave Library, 1987. Chapter~13]. Such behavior is explained by the characteristic features of the dynamics of electron space charge in the longitudinal and radial directions in the drift space at the different external magnetic fields.

  7. High current density ion beam obtained by a transition to a highly focused state in extremely low-energy region.

    Science.gov (United States)

    Hirano, Y; Kiyama, S; Fujiwara, Y; Koguchi, H; Sakakita, H

    2015-11-01

    A high current density (≈3 mA/cm(2)) hydrogen ion beam source operating in an extremely low-energy region (E(ib) ≈ 150-200 eV) has been realized by using a transition to a highly focused state, where the beam is extracted from the ion source chamber through three concave electrodes with nominal focal lengths of ≈350 mm. The transition occurs when the beam energy exceeds a threshold value between 145 and 170 eV. Low-level hysteresis is observed in the transition when E(ib) is being reduced. The radial profiles of the ion beam current density and the low temperature ion current density can be obtained separately using a Faraday cup with a grid in front. The measured profiles confirm that more than a half of the extracted beam ions reaches the target plate with a good focusing profile with a full width at half maximum of ≈3 cm. Estimation of the particle balances in beam ions, the slow ions, and the electrons indicates the possibility that the secondary electron emission from the target plate and electron impact ionization of hydrogen may play roles as particle sources in this extremely low-energy beam after the compensation of beam ion space charge.

  8. Current Transformers for GSI's KeV/u to GeV/u Ion Beams an Overview

    CERN Document Server

    Reeg, H

    2001-01-01

    At GSI's accelerator facilities ion beam intensities usually are observed and measured with various types of current transformers (CT), matched to the special requirements at their location in the machines. In the universal linear accelerator (UNILAC), and the high charge state injector (HLI) as well, active transformers with 2nd-order feedback are used, while passive pulse CTs and two DC-CTs based on the magnetic modulator principle are implemented in the heavy ion synchrotron (SIS) and the experimental storage ring (ESR). In the high energy beam transfer lines (HEBT) the particle bunch extraction/reinjection is monitored with resonant charge-integrating types. Since more than 10 years number and significance of beam current transformers for operating GSI's accelerators have grown constantly. Due to increased beam intensities following the last UNILAC upgrade, transmission monitoring and beam loss supervision with CTs have become the main tools for machine protection and radiation security purposes. All CTs ...

  9. Neutral-beam current-driven high-poloidal-beta operation of the DIII-D tokamak

    Science.gov (United States)

    Simonen, T. C.; Matsuoka, M.; Bhadra, D. K.; Burrell, K. H.; Callis, R. W.; Chance, M. S.; Chu, M. S.; Greene, J. M.; Groebner, R. J.; Harvey, R. W.; Hill, D. N.; Kim, J.; Lao, L.; Petersen, P. I.; Porter, G. D.; St. John, H.; Stallard, B. W.; Stambaugh, R. D.; Strait, E. J.; Taylor, T. S.

    1988-10-01

    Neutral-beam current-drive experiments in the DIII-D tokamak with a single null poloidal divertor are described. A plasma current of 0.34 MA has been sustained by neutral beams alone, and the energy confinement is of H-mode quality. Poloidal β values reach 3.5 without disruption or coherent magnetic activity suggesting that these plasmas may be entering the second stability regime.

  10. Observation of coherent transition radiation using relativistic pico second electron pulse

    Energy Technology Data Exchange (ETDEWEB)

    Jones, C.R.; Kosai, H.; Dutt, J.M. [North Carolina Central Univ., Durham, NC (United States)

    1995-12-31

    When an electron beams passes through boundaries of two different media with different dielectric constants, it generates radiation. The radiation emitted by the prebunched electron beam becomes coherent if the size of the bunch is smaller than the wavelength. Therefore, transition radiation can be considered as a possible broad band radiation source as well as a probe to the pico second and sub picosecond electron beam profiles. Using 1.2 MeV, 200 mA, macropulse electron beam, transition radiation was generated. The electron gun consists of 2.856 GHz Klystron, thermionic cathode. The emitted electron beam was bunched by passing through an alpha magnet. As a result of the combination, a pico second pulse (1.2 MeV, up to 80 A micropulse) was obtained. Experimental results, comparisons with the theory, and simulated electron beam profiles will be presented.

  11. Typicals/Típicos

    Directory of Open Access Journals (Sweden)

    Silvia Vélez

    2004-01-01

    Full Text Available Typicals is a series of 12 colour photographs digitally created from photojournalistic images from Colombia combined with "typical" craft textiles and text from guest writers. Typicals was first exhibited as photographs 50cm x 75cm in size, each with their own magnifying glass, at the Contemporary Art Space at Gorman House in Canberra, Australia, in 2000. It was then exhibited in "Feedback: Art Social Consciousness and Resistance" at Monash University Museum of Art in Melbourne, Australia, from March to May 2003. From May to June 2003 it was exhibited at the Museo de Arte de la Universidad Nacional de Colombia Santa Fé Bogotá, Colombia. In its current manifestation the artwork has been adapted from the catalogue of the museum exhibitions. It is broken up into eight pieces corresponding to the contributions of the writers. The introduction by Sylvia Vélez is the PDF file accessible via a link below this abstract. The other seven PDF files are accessible via the 'Research Support Tool' section to the right of your screen. Please click on 'Supp. Files'. Please note that these files are around 4 megabytes each, so it may be difficult to access them from a dial-up connection.

  12. Calibration of eddy current carburization measurements in ethylene production tubes using ion beam analysis

    Energy Technology Data Exchange (ETDEWEB)

    Stevens, K J [Materials Performance Technologies, Industrial Research Ltd, PO Box 31-310, Lower Hutt (New Zealand); Trompetter, W J [Rafter Laboratory, Institute of Geological and Nuclear Sciences, PO Box 31-312, Lower Hutt (New Zealand)

    2004-02-07

    Nuclear reaction analysis using a {sup 12}C(d, p{sub 0}){sup 13}C reaction and a {sup 16}O(d, p{sub 1}){sup 17}O reaction, with 1.02 MeV deuterons in an accelerator microprobe, has been used to produce quantitative linescans of the carbon and oxygen levels in ex-service ethylene pyrolysis tubes of HPM, HK40 and Manaurite XM alloy. Particle induced x-ray emission in the ion beam microprobe and energy dispersive analysis of x-rays in a scanning electron microscope were used for linescans of the heavier elements (Cr, Ni, Fe, Si and Ti). The composition linescans were used to calibrate the response and accuracy of an eddy current probe system for measuring carburization near the inner surface of the tubes. The influence of the ferromagnetic outer oxide surface layers has been clarified. A two-dimensional ANSYS finite element model (FEM) was used for interpretation of the eddy current scans. Good correlation was obtained between the ion beam analysis results, the impedance scans and the FEM.

  13. Calibration of eddy current carburization measurements in ethylene production tubes using ion beam analysis

    Science.gov (United States)

    Stevens, K. J.; Trompetter, W. J.

    2004-02-01

    Nuclear reaction analysis using a 12C(d, p0)13C reaction and a 16O(d, p1)17O reaction, with 1.02 MeV deuterons in an accelerator microprobe, has been used to produce quantitative linescans of the carbon and oxygen levels in ex-service ethylene pyrolysis tubes of HPM, HK40 and Manaurite XM alloy. Particle induced x-ray emission in the ion beam microprobe and energy dispersive analysis of x-rays in a scanning electron microscope were used for linescans of the heavier elements (Cr, Ni, Fe, Si and Ti). The composition linescans were used to calibrate the response and accuracy of an eddy current probe system for measuring carburization near the inner surface of the tubes. The influence of the ferromagnetic outer oxide surface layers has been clarified. A two-dimensional ANSYS finite element model (FEM) was used for interpretation of the eddy current scans. Good correlation was obtained between the ion beam analysis results, the impedance scans and the FEM.

  14. Surface modification of Al-Pb alloy by high current pulsed electron beam

    Institute of Scientific and Technical Information of China (English)

    LU You; LI Shi-long; AN Jian; LIU Yong-bing

    2006-01-01

    Al-Pb alloy was modified by high current pulsed electron beam and the microstructure, hardness and tribological characteristics were characterized by scanning electron microscopy, electronic microanalysis probe microanalysis, Knoop hardness indentation and pin-on-disc type wear testing machine. The results show that the microstructure and hardness can be greatly improved, and the modification layer consists of a molten zone, an overlapped zone of heat-affected and quasistatic thermal stress-affected zone and a transition zone followed by the substrate. The tribological properties of high current pulsed electron beam irradiated Al-Pb alloy are correspondingly improved largely. Optical observation and scanning electron microscopy analysis reveal that the low wear rate and lowest level in coefficient of friction at high load level for irradiated Al-Pb alloy are due to the formation of a lubricious tribolayer covering the worn surface, which is a mixture of Al2O3, Pb3O4 and silicate. The wear mode varies from oxidative wear at low load to film spalling at high load and, finally, adhesive wear.

  15. Various categories of defects after surface alloying induced by high current pulsed electron beam irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Dian [State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001 (China); Tang, Guangze, E-mail: oaktang@hit.edu.cn [School of Material Science & Engineering, Harbin Institute of Technology, Harbin 150001 (China); Ma, Xinxin [State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001 (China); Gu, Le [School of Mechatronics Engineering, Harbin Institute of Technology, Harbin 150001 (China); Sun, Mingren [School of Material Science & Engineering, Harbin Institute of Technology, Harbin 150001 (China); Wang, Liqin [School of Mechatronics Engineering, Harbin Institute of Technology, Harbin 150001 (China)

    2015-10-01

    Highlights: • Four kinds of defects are found during surface alloying by high current electron beam. • Exploring the mechanism how these defects appear after irradiation. • Increasing pulsing cycles will help to get good surface quality. • Choosing proper energy density will increase surface quality. - Abstract: High current pulsed electron beam (HCPEB) is an attractive advanced materials processing method which could highly increase the mechanical properties and corrosion resistance. However, how to eliminate different kinds of defects during irradiation by HCPEB especially in condition of adding new elements is a challenging task. In the present research, the titanium and TaNb-TiW composite films was deposited on the carburizing steel (SAE9310 steel) by DC magnetron sputtering before irradiation. The process of surface alloying was induced by HCPEB with pulse duration of 2.5 μs and energy density ranging from 3 to 9 J/cm{sup 2}. Investigation of the microstructure indicated that there were several forms of defects after irradiation, such as surface unwetting, surface eruption, micro-cracks and layering. How the defects formed was explained by the results of electron microscopy and energy dispersive spectroscopy. The results also revealed that proper energy density (∼6 J/cm{sup 2}) and multi-number of irradiation (≥50 times) contributed to high quality of alloyed layers after irradiation.

  16. Solar cell evaluation using electron beam induced current with the large chamber scanning electron microscope

    Science.gov (United States)

    Wink, Tara; Kintzel, Edward; Marienhoff, Peter; Klein, Martin

    2012-02-01

    An initial study using electron beam induced current (EBIC) to evaluate solar cells has been carried out with the large chamber scanning electron microscope (LC-SEM) at the Western Kentucky University Nondestructive Analysis Center. EBIC is a scanning electron microscope technique used for the characterization of semiconductors. To facilitate our studies, we developed a Solar Amplification System (SASY) for analyzing current distribution and defects within a solar cell module. Preliminary qualitative results will be shown for a solar cell module that demonstrates the viability of the technique using the LC-SEM. Quantitative EBIC experiments will be carried out to analyze defects and minority carrier properties. Additionally, a well-focused spot of light from an LED mounted at the side of the SEM column will scan the same area of the solar cell using the LC-SEM positioning system. SASY will then output the solar efficiency to be compared with the minority carrier properties found using EBIC.

  17. New methods for high current fast ion beam production by laser-driven acceleration

    Energy Technology Data Exchange (ETDEWEB)

    Margarone, D.; Krasa, J.; Prokupek, J.; Velyhan, A.; Laska, L.; Jungwirth, K.; Mocek, T.; Korn, G.; Rus, B. [Institute of Physics, ASCR, v.v.i., PALS Centre, Prague (Czech Republic); Torrisi, L.; Gammino, S.; Cirrone, P.; Cutroneo, M.; Romano, F. [INFN-Laboratori Nazionali del Sud, Catania, Messina University (Italy); Picciotto, A.; Serra, E. [Fondazione Bruno Kessler - IRST, Trento (Italy); Giuffrida, L. [CELIA, Centre Lasers Intenses et Applications (France); Mangione, A. [ITA - Istituto Tecnologie Avanzate, Trapani (Italy); Rosinski, M.; Parys, P. [Institute of Plasma Physics and Laser Microfusion, Warsaw (Poland); and others

    2012-02-15

    An overview of the last experimental campaigns on laser-driven ion acceleration performed at the PALS facility in Prague is given. Both the 2 TW, sub-nanosecond iodine laser system and the 20 TW, femtosecond Ti:sapphire laser, recently installed at PALS, are used along our experiments performed in the intensity range 10{sup 16}-10{sup 19} W/cm{sup 2}. The main goal of our studies was to generate high energy, high current ion streams at relatively low laser intensities. The discussed experimental investigations show promising results in terms of maximum ion energy and current density, which make the laser-accelerated ion beams a candidate for new-generation ion sources to be employed in medicine, nuclear physics, matter physics, and industry.

  18. New methods for high current fast ion beam production by laser-driven accelerationa)

    Science.gov (United States)

    Margarone, D.; Krasa, J.; Prokupek, J.; Velyhan, A.; Torrisi, L.; Picciotto, A.; Giuffrida, L.; Gammino, S.; Cirrone, P.; Cutroneo, M.; Romano, F.; Serra, E.; Mangione, A.; Rosinski, M.; Parys, P.; Ryc, L.; Limpouch, J.; Laska, L.; Jungwirth, K.; Ullschmied, J.; Mocek, T.; Korn, G.; Rus, B.

    2012-02-01

    An overview of the last experimental campaigns on laser-driven ion acceleration performed at the PALS facility in Prague is given. Both the 2 TW, sub-nanosecond iodine laser system and the 20 TW, femtosecond Ti:sapphire laser, recently installed at PALS, are used along our experiments performed in the intensity range 1016-1019 W/cm2. The main goal of our studies was to generate high energy, high current ion streams at relatively low laser intensities. The discussed experimental investigations show promising results in terms of maximum ion energy and current density, which make the laser-accelerated ion beams a candidate for new-generation ion sources to be employed in medicine, nuclear physics, matter physics, and industry.

  19. New methods for high current fast ion beam production by laser-driven acceleration.

    Science.gov (United States)

    Margarone, D; Krasa, J; Prokupek, J; Velyhan, A; Torrisi, L; Picciotto, A; Giuffrida, L; Gammino, S; Cirrone, P; Cutroneo, M; Romano, F; Serra, E; Mangione, A; Rosinski, M; Parys, P; Ryc, L; Limpouch, J; Laska, L; Jungwirth, K; Ullschmied, J; Mocek, T; Korn, G; Rus, B

    2012-02-01

    An overview of the last experimental campaigns on laser-driven ion acceleration performed at the PALS facility in Prague is given. Both the 2 TW, sub-nanosecond iodine laser system and the 20 TW, femtosecond Ti:sapphire laser, recently installed at PALS, are used along our experiments performed in the intensity range 10(16)-10(19) W∕cm(2). The main goal of our studies was to generate high energy, high current ion streams at relatively low laser intensities. The discussed experimental investigations show promising results in terms of maximum ion energy and current density, which make the laser-accelerated ion beams a candidate for new-generation ion sources to be employed in medicine, nuclear physics, matter physics, and industry.

  20. 10 Orders of Magnitude Current Measurement Digitisers for the CERN Beam Loss Systems

    CERN Document Server

    Vigano, W; Dehning, B; Kwiatkowski, M; Venturini, G G; Zamantzas, C

    2014-01-01

    A wide range current digitizer card is needed for the acquisition module of the beam loss monitoring systems in the CERN Injector Complex. The fully differential frequency converter allows measuring positive and negative input currents with a resolution of 31nA in an integration window of 2μs. Increasing the integration window, the dynamic range covers 2•1010 were the upper part of the range is converted by measuring directly the voltage drop on a resistor. The key elements of this design are the fully differential integrator and the switches operated by an FPGA. The circuit is designed to avoid any dead time in the acquisition and reliability and failsafe operational considerations are main design goals. The circuit will be discussed in detail and lab and field measurements will be shown.

  1. 10 orders of magnitude current measurement digitisers for the CERN beam loss systems

    Science.gov (United States)

    Viganò, W.; Alsdorf, M.; Dehning, B.; Kwiatkowski, M.; Venturini, G. G.; Zamantzas, C.

    2014-02-01

    A wide range current digitizer card is needed for the acquisition module of the beam loss monitoring systems in the CERN Injector Complex. The fully differential frequency converter allows measuring positive and negative input currents with a resolution of 31 nA in an integration window of 2 μs. Increasing the integration window, the dynamic range covers 21010 were the upper part of the range is converted by measuring directly the voltage drop on a resistor. The key elements of this design are the fully differential integrator and the switches operated by an FPGA. The circuit is designed to avoid any dead time in the acquisition and reliability and failsafe operational considerations are main design goals. The circuit will be discussed in detail and lab and field measurements will be shown.

  2. Tailored electron bunches with smooth current profiles for enhanced transformer ratios in beam-driven acceleration

    CERN Document Server

    Lemery, Francois

    2015-01-01

    Collinear high-gradient ${\\cal O} (GV/m)$ beam-driven wakefield methods for charged-particle acceleration could be critical to the realization of compact, cost-efficient, accelerators, e.g., in support of TeV-scale lepton colliders or multiple-user free-electron laser facilities. To make these options viable, the high accelerating fields need to be complemented with large transformer ratios $>2$, a parameter characterizing the efficiency of the energy transfer between a wakefield-exciting "drive" bunch to an accelerated "witness" bunch. While several potential current distributions have been discussed, their practical realization appears challenging due to their often discontinuous nature. In this paper we propose several alternative current profiles which are smooth which also lead to enhanced transformer ratios. We especially explore a laser-shaping method capable of generating one the suggested distributions directly out of a photoinjector and discuss a linac concept that could possible drive a dielectric ...

  3. Measurement of inclusive charged current interactions on carbon in a few-GeV neutrino beam

    CERN Document Server

    jima, Y Naka; Brice, S J; Bugel, L; Catala-Perez, J; Cheng, G; Conrad, J M; Djurcic, Z; Dore, U; Finley, D A; Franke, A J; Giganti, C; Gomez-Cadenas, J J; Guzowski, P; Hanson, A; Hayato, Y; Hiraide, K; Jover-Manas, G; Karagiorgi, G; Katori, T; Kobayashi, Y K; Kobilarcik, T; Kubo, H; Kurimoto, Y; Louis, W C; Loverre, P F; Ludovici, L; Mahn, K B M; Mariani, C; Masuike, S; Matsuoka, K; McGary, V T; Metcalf, W; Mills, G B; Mitsuka, G; Miyachi, Y; Mizugashira, S; Moore, C D; Nakaya, T; Napora, R; Nienaber, P; Orme, D; Otani, M; Russell, A D; Sanchez, F; Shaevitz, M H; Shibata, T -A; Sorel, M; Stefanski, R J; Takei, H; Tanaka, H -K; Tanaka, M; Tayloe, R; Taylor, I J; Tesarek, R J; Uchida, Y; Van de Water, R; Walding, J J; Wascko, M O; White, H B; Yokoyama, M; Zeller, G P; Zimmerman, E D

    2010-01-01

    The SciBooNE Collaboration reports a measurement of inclusive charged current interactions of muon neutrinos on carbon with an average energy of 0.8~GeV using the Fermilab Booster Neutrino Beam. We compare our measurement with two neutrino interaction simulations: NEUT and NUANCE. The charged current interaction rates (product of flux and cross section) are extracted by fitting the muon kinematics, with a precision of 6-15% for the energy dependent and 3% for the energy integrated analyses. We also extract CC inclusive interaction cross sections from the observed rates, with a precision of 10-30% for the energy dependent and 8% for the energy integrated analyses. This is the first measurement of the CC inclusive cross section on carbon around 1 GeV. These results can be used to convert previous SciBooNE cross section ratio measurements to absolute cross section values.

  4. Measurement of inclusive charged current interactions on carbon in a few-GeV neutrino beam

    Energy Technology Data Exchange (ETDEWEB)

    Nakajima, Y.; jima, Y.Naka; Alcaraz-Aunion, J.L.; Brice, S.J.; Bugel, L.; Catala-Perez, J.; Cheng, G.; Conrad, J.M.; Djurcic, Z.; Dore, U.; Finley, D.A.; /Kyoto U. /Barcelona, IFAE /Fermilab /MIT /Valencia U. /Columbia U. /MIT /Columbia U. /INFN, Rome /Rome U. /Fermilab /Columbia U. /INFN, Rome /Rome U.

    2010-11-01

    The SciBooNE Collaboration reports a measurement of inclusive charged current interactions of muon neutrinos on carbon with an average energy of 0.8 GeV using the Fermilab Booster Neutrino Beam. We compare our measurement with two neutrino interaction simulations: NEUT and NUANCE. The charged current interaction rates (product of flux and cross section) are extracted by fitting the muon kinematics, with a precision of 6-15% for the energy dependent and 3% for the energy integrated analyses. We also extract CC inclusive interaction cross sections from the observed rates, with a precision of 10-30% for the energy dependent and 8% for the energy integrated analyses. This is the first measurement of the CC inclusive cross section on carbon around 1 GeV. These results can be used to convert previous SciBooNE cross section ratio measurements to absolute cross section values.

  5. High-resolution velocimetry in energetic tidal currents using a convergent-beam acoustic Doppler profiler

    Science.gov (United States)

    Sellar, Brian; Harding, Samuel; Richmond, Marshall

    2015-08-01

    An array of single-beam acoustic Doppler profilers has been developed for the high resolution measurement of three-dimensional tidal flow velocities and subsequently tested in an energetic tidal site. This configuration has been developed to increase spatial resolution of velocity measurements in comparison to conventional acoustic Doppler profilers (ADPs) which characteristically use divergent acoustic beams emanating from a single instrument. This is achieved using geometrically convergent acoustic beams creating a sample volume at the focal point of 0.03 m3. Away from the focal point, the array is also able to simultaneously reconstruct three-dimensional velocity components in a profile throughout the water column, and is referred to herein as a convergent-beam acoustic Doppler profiler (C-ADP). Mid-depth profiling is achieved through integration of the sensor platform with the operational commercial-scale Alstom 1 MW DeepGen-IV Tidal Turbine deployed at the European Marine Energy Center, Orkney Isles, UK. This proof-of-concept paper outlines the C-ADP system configuration and comparison to measurements provided by co-installed reference instrumentation. Comparison of C-ADP to standard divergent ADP (D-ADP) velocity measurements reveals a mean difference of 8 mm s-1, standard deviation of 18 mm s-1, and an order of magnitude reduction in realisable length scale. C-ADP focal point measurements compared to a proximal single-beam reference show peak cross-correlation coefficient of 0.96 over 4.0 s averaging period and a 47% reduction in Doppler noise. The dual functionality of the C-ADP as a profiling instrument with a high resolution focal point make this configuration a unique and valuable advancement in underwater velocimetry enabling improved quantification of flow turbulence. Since waves are simultaneously measured via profiled velocities, pressure measurements and surface detection, it is expected that derivatives of this system will be a powerful tool in

  6. Structural transitions in electron beam deposited Co–carbonyl suspended nanowires at high electrical current densities

    Directory of Open Access Journals (Sweden)

    Gian Carlo Gazzadi

    2015-06-01

    Full Text Available Suspended nanowires (SNWs have been deposited from Co–carbonyl precursor (Co2(CO8 by focused electron beam induced deposition (FEBID. The SNWs dimensions are about 30–50 nm in diameter and 600–850 nm in length. The as-deposited material has a nanogranular structure of mixed face-centered cubic (FCC and hexagonal close-packed (HCP Co phases, and a composition of 80 atom % Co, 15 atom % O and 5 atom % C, as revealed by transmission electron microscopy (TEM analysis and by energy-dispersive X-ray (EDX spectroscopy, respectively. Current (I–voltage (V measurements with current densities up to 107 A/cm2 determine different structural transitions in the SNWs, depending on the I–V history. A single measurement with a sudden current burst leads to a polycrystalline FCC Co structure extended over the whole wire. Repeated measurements at increasing currents produce wires with a split structure: one half is polycrystalline FCC Co and the other half is graphitized C. The breakdown current density is found at 2.1 × 107 A/cm2. The role played by resistive heating and electromigration in these transitions is discussed.

  7. Structural transitions in electron beam deposited Co-carbonyl suspended nanowires at high electrical current densities.

    Science.gov (United States)

    Gazzadi, Gian Carlo; Frabboni, Stefano

    2015-01-01

    Suspended nanowires (SNWs) have been deposited from Co-carbonyl precursor (Co2(CO)8) by focused electron beam induced deposition (FEBID). The SNWs dimensions are about 30-50 nm in diameter and 600-850 nm in length. The as-deposited material has a nanogranular structure of mixed face-centered cubic (FCC) and hexagonal close-packed (HCP) Co phases, and a composition of 80 atom % Co, 15 atom % O and 5 atom % C, as revealed by transmission electron microscopy (TEM) analysis and by energy-dispersive X-ray (EDX) spectroscopy, respectively. Current (I)-voltage (V) measurements with current densities up to 10(7) A/cm(2) determine different structural transitions in the SNWs, depending on the I-V history. A single measurement with a sudden current burst leads to a polycrystalline FCC Co structure extended over the whole wire. Repeated measurements at increasing currents produce wires with a split structure: one half is polycrystalline FCC Co and the other half is graphitized C. The breakdown current density is found at 2.1 × 10(7) A/cm(2). The role played by resistive heating and electromigration in these transitions is discussed.

  8. Amplification of Cooper pair splitting current in a graphene-based Cooper pair beam splitter geometry

    Science.gov (United States)

    Islam, SK Firoz; Saha, Arijit

    2017-09-01

    Motivated by the recent experiments [Scientific Reports 6, 23051 (2016), 10.1038/srep23051; Phys. Rev. Lett. 114, 096602 (2015), 10.1103/PhysRevLett.114.096602], we theoretically investigate Cooper pair splitting current in a graphene-based Cooper pair beam splitter geometry. By considering the graphene-based superconductor as an entangler device, instead of normal [two-dimensional (2D)] BCS superconductor, we show that the Cooper pair splitting current mediated by the crossed Andreev process is amplified compared to its normal superconductor counterpart. This amplification is attributed to the strong suppression of the local normal Andreev reflection process (arising from the Cooper pair splitting) from the graphene-based superconductor to lead via the same quantum dot, in comparison to the usual 2D superconductor. Due to the vanishing density of states at the Dirac point of undoped graphene, a doped graphene-based superconductor is considered here and it is observed that Cooper pair splitting current is very insensitive to the doping level in comparison to the usual 2D superconductor. The transport process of nonlocal spin-entangled electrons also depends on the type of pairing, i.e., whether the electron-hole pairing is onsite, intersublattice or the combination of both. The intersublattice pairing of graphene causes the maximum nonlocal Cooper pair splitting current, whereas the presence of both pairings reduces the Cooper pair splitting current.

  9. Cyclic AMP efflux inhibitors as potential therapeutic agents for leukemia

    Science.gov (United States)

    Perez, Dominique R.; Smagley, Yelena; Garcia, Matthew; Carter, Mark B.; Evangelisti, Annette; Matlawska-Wasowska, Ksenia; Winter, Stuart S.; Sklar, Larry A.; Chigaev, Alexandre

    2016-01-01

    Apoptotic evasion is a hallmark of cancer. We propose that some cancers may evade cell death by regulating 3′-5′-cyclic adenosine monophosphate (cAMP), which is associated with pro-apoptotic signaling. We hypothesize that leukemic cells possess mechanisms that efflux cAMP from the cytoplasm, thus protecting them from apoptosis. Accordingly, cAMP efflux inhibition should result in: cAMP accumulation, activation of cAMP-dependent downstream signaling, viability loss, and apoptosis. We developed a novel assay to assess cAMP efflux and performed screens to identify inhibitors. In an acute myeloid leukemia (AML) model, several identified compounds reduced cAMP efflux, appropriately modulated pathways that are responsive to cAMP elevation (cAMP-responsive element-binding protein phosphorylation, and deactivation of Very Late Antigen-4 integrin), and induced mitochondrial depolarization and caspase activation. Blocking adenylyl cyclase activity was sufficient to reduce effects of the most potent compounds. These compounds also decreased cAMP efflux and viability of B-lineage acute lymphoblastic leukemia (B-ALL) cell lines and primary patient samples, but not of normal primary peripheral blood mononuclear cells. Our data suggest that cAMP efflux is a functional feature that could be therapeutically targeted in leukemia. Furthermore, because some of the identified drugs are currently used for treating other illnesses, this work creates an opportunity for repurposing. PMID:27129155

  10. Phosphodiesterase 4 and compartmentalization of cyclic AMP signaling

    Institute of Scientific and Technical Information of China (English)

    WANG ZhengChao; SHI FangXiong

    2007-01-01

    Cyclic AMP (cAMP), as a second messenger, plays a critical role in cellular signaling transduction. However, it is not clear how this apparently identical cAMP signal induces divergent physiological responses. The potential explanation that cAMP signaling is compartmentalized was proposed by Buxton and Brunton twenty years ago. Compartmentalization of cAMP signaling allows spatially distinct pools of protein kinase A (PKA) to be differently activated. Research on cAMP signaling has regained impetus in many fields of life sciences due to the progress in understanding cAMP signaling complexity and functional diversity. The cAMP/PKA signaling compartments are maintained by A-kinase anchoring proteins (AKAPs) which bind PKA and other signaling proteins, and by PDEs which hydrolyse cAMP and thus terminate PKA activity. PDE4 enzymes belong to PDE superfamily and stand at a crossroad that allows them to integrate various signaling pathways with that of cAMP in spatially distinct compartments. In the current review, the nomenclature, taxonomy and gene expression of PDE4, and the system and region of its effect are described. In addition, the idiographic molecules, mechanisms, and regulation models of PDE4 are summarized. Furthermore, the important roles PDE4 plays in the maturation of rat granulosa cells and cAMP signaling compartmentalization are discussed.

  11. Antimicrobial Peptides (AMPs

    Directory of Open Access Journals (Sweden)

    Mehrzad Sadredinamin

    2016-04-01

    Full Text Available Antimicrobial peptides (AMPs are extensive group of molecules that produced by variety tissues of invertebrate, plants, and animal species which play an important role in their immunity response. AMPs have different classifications such as; biosynthetic machines, biological sources, biological functions, molecular properties, covalent bonding patterns, three dimensional structures, and molecular targets.These molecules have multidimensional properties including antimicrobial activity, antiviral activity, antifungal activity, anti-parasite activity, biofilm control, antitumor activity, mitogens activity and linking innate to adaptive immunity that making them promising agents for therapeutic drugs. In spite of this advantage of AMPs, their clinical developments have some limitation for commercial development. But some of AMPs are under clinical trials for the therapeutic purpose such as diabetic foot ulcers, different bacterial infections and tissue damage. In this review, we emphasized on the source, structure, multidimensional properties, limitation and therapeutic applications of various antimicrobial peptides.

  12. Cathode performance during two beam operation of the high current high polarization electron gun for eRHIC

    Energy Technology Data Exchange (ETDEWEB)

    Rahman, O. [Brookhaven National Lab. (BNL), Upton, NY (United States); Ben-Zvi, I. [Brookhaven National Lab. (BNL), Upton, NY (United States); Degen, C. [Brookhaven National Lab. (BNL), Upton, NY (United States); Gassner, D. M. [Brookhaven National Lab. (BNL), Upton, NY (United States); Lambiase, R. [Brookhaven National Lab. (BNL), Upton, NY (United States); Meng, W. [Brookhaven National Lab. (BNL), Upton, NY (United States); Pikin, A. [Brookhaven National Lab. (BNL), Upton, NY (United States); Rao, T. [Brookhaven National Lab. (BNL), Upton, NY (United States); Sheehy, B. [Brookhaven National Lab. (BNL), Upton, NY (United States); Skaritka, J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Wang, E. [Brookhaven National Lab. (BNL), Upton, NY (United States); Pietz, J. [Transfer Engineering and Manufacturing, Inc., Fremont, CA (United States); Ackeret, M. [Transfer Engineering and Manufacturing, Inc., Fremont, CA (United States); Yeckel, C. [Stangenes Industries, Palo Alto, CA (United States); Miller, R. [Stangenes Industries, Palo Alto, CA (United States); Dobrin, E. [Stangenes Industries, Palo Alto, CA (United States); Thompson, K. [Stangenes Industries, Palo Alto, CA (United States)

    2015-05-03

    Two electron beams from two activated bulk GaAs photocathodes were successfully combined during the recent beam test of the High Current High Polarization Electron gun for eRHIC. The beam test took place in Stangenes Industries in Palo Alto, CA, where the cathodes were placed in diagonally opposite locations inside the high voltage shroud. No significant cross talking between the cathodes was found for the pertinent vacuum and low average current operation, which is very promising towards combining multiple beams for higher average current. This paper describes the cathode preparation, transport and cathode performance in the gun for the combining test, including the QE and lifetimes of the photocathodes at various steps of the experiment.

  13. Electron beam dynamics in the long-pulse, high-current DARHT-II linear induction accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Ekdahl, Carl A [Los Alamos National Laboratory; Abeyta, Epifanio O [Los Alamos National Laboratory; Aragon, Paul [Los Alamos National Laboratory; Archuleta, Rita [Los Alamos National Laboratory; Cook, Gerald [Los Alamos National Laboratory; Dalmas, Dale [Los Alamos National Laboratory; Esquibel, Kevin [Los Alamos National Laboratory; Gallegos, Robert A [Los Alamos National Laboratory; Garnett, Robert [Los Alamos National Laboratory; Harrison, James F [Los Alamos National Laboratory; Johnson, Jeffrey B [Los Alamos National Laboratory; Jacquez, Edward B [Los Alamos National Laboratory; Mccuistian, Brian T [Los Alamos National Laboratory; Montoya, Nicholas A [Los Alamos National Laboratory; Nath, Subrato [Los Alamos National Laboratory; Nielsen, Kurt [Los Alamos National Laboratory; Oro, David [Los Alamos National Laboratory; Prichard, Benjamin [Los Alamos National Laboratory; Rowton, Lawrence [Los Alamos National Laboratory; Sanchez, Manolito [Los Alamos National Laboratory; Scarpetti, Raymond [Los Alamos National Laboratory; Schauer, Martin M [Los Alamos National Laboratory; Seitz, Gerald [Los Alamos National Laboratory; Schulze, Martin [Los Alamos National Laboratory; Bender, Howard A [Los Alamos National Laboratory; Broste, William B [Los Alamos National Laboratory; Carlson, Carl A [Los Alamos National Laboratory; Frayer, Daniel K [Los Alamos National Laboratory; Johnson, Douglas E [Los Alamos National Laboratory; Tom, C Y [Los Alamos National Laboratory; Williams, John [Los Alamos National Laboratory; Hughes, Thomas [Los Alamos National Laboratory; Anaya, Richard [LLNL; Caporaso, George [LLNL; Chambers, Frank [LLNL; Chen, Yu - Jiuan [LLNL; Falabella, Steve [LLNL; Guethlein, Gary [LLNL; Raymond, Brett [LLNL; Richardson, Roger [LLNL; Trainham, C [NSTEC/STL; Watson, Jim [LLNL; Weir, John [LLNL; Genoni, Thomas [VOSS; Toma, Carsten [VOSS

    2009-01-01

    The DARHT-II linear induction accelerator (LIA) now accelerates 2-kA electron beams to more than 17 MeV. This LIA is unique in that the accelerated current pulse width is greater than 2 microseconds. This pulse has a flat-top region where the final electron kinetic energy varies by less than 1% for more than 1.5 microseconds. The long risetime of the 6-cell injector current pulse is 0.5 {micro}s, which can be scraped off in a beam-head cleanup zone before entering the 68-cell main accelerator. We discuss our experience with tuning this novel accelerator; and present data for the resulting beam transport and dynamics. We also present beam stability data, and relate these to previous stability experiments at lower current and energy.

  14. A particle-core-MD model for intrabeam scattering and halo formation in high current beams in a FODO channel

    CERN Document Server

    Uhlmann, N; Comunian, M; Pisent, A

    2002-01-01

    An essential problem for the successful operation of high current linear ion accelerators is the control of beam losses due to halo particles. As a possible mechanism for the formation of such a halo we concentrate on the interplay between intrabeam scattering (IBS) and the incidence of particles which are driven to high amplitudes by resonances with the nonlinear space charge fields of a mismatched beam. Since a fully microscopic numerical treatment including all the mutual Coulomb interactions between the beam ions requires much too high computational effort, we developed an approximative method. These particle-core-molecular-dynamics (PCMD) simulations suitably join the mean-field description of the time evolution of the beam in framework of the envelope equations and a microscopic calculation of the Coulomb interactions between pseudo-particles with a renormalized charge. With this method we studied matched and mismatched continuous KV-beams in a FODO channel. In first simulation runs we observed a signif...

  15. Model of convection mass transfer in titanium alloy at low energy high current electron beam action

    Science.gov (United States)

    Sarychev, V. D.; Granovskii, A. Yu; Nevskii, S. A.; Konovalov, S. V.; Gromov, V. E.

    2017-01-01

    The convection mixing model is proposed for low-energy high-current electron beam treatment of titanium alloys, pre-processed by heterogeneous plasma flows generated via explosion of carbon tape and powder TiB2. The model is based on the assumption vortices in the molten layer are formed due to the treatment by concentrated energy flows. These vortices evolve as the result of thermocapillary convection, arising because of the temperature gradient. The calculation of temperature gradient and penetration depth required solution of the heat problem with taking into account the surface evaporation. However, instead of the direct heat source the boundary conditions in phase transitions were changed in the thermal conductivity equation, assuming the evaporated material takes part in the heat exchange. The data on the penetration depth and temperature distribution are used for the thermocapillary model. The thermocapillary model embraces Navier-Stocks and convection heat transfer equations, as well as the boundary conditions with the outflow of evaporated material included. The solution of these equations by finite elements methods pointed at formation of a multi-vortices structure when electron-beam treatment and its expansion over new zones of material. As the result, strengthening particles are found at the depth exceeding manifold their penetration depth in terms of the diffusion mechanism.

  16. Surface treatment of 0.20% C carbon steel by high-current pulsed electron beam

    Institute of Scientific and Technical Information of China (English)

    XU Guo-cheng; FU Shi-you; GUAN Qing-feng

    2006-01-01

    A high-current pulsed electron beam(HCPEB) generated on the system of Nadezhda-2 was applied to improve the microstructure and performance of 0.20% C low carbon steel. Surface layers of the samples bombarded by explosive electron beam at different pulses was observed by using electron microscopy. The physical model of the thermal-stress process and related modification mechanism as a result of HCPEB irradiation was also investigated. After HCPEB post treatments, obvious changes in microstructure and significant hardening occur in the depth of 200-250 μm from the surface after HCPEB irradiation. Rapid heating and subsequent rapid solidification induce heavy plastic deformation, which results in that the laminated structure of pearlite is substituted by dispersive rounded-like cementites in the near-surface. The effect of HCPEB treatment can reach more than 500 m depth from the surface. The original crystalline structure is changed to a different degree that grows with the numbers of bombardment, and in the surface layer amorphous states and nanocrystaline structures consisting of grains of γ-phase and cementite are found. The violent stress induced by HCPEB irradiation is the origin of the nanostructured and amorphous structure formation.

  17. Degradation and decoloration of textiles wastewater by electron beam irradiation: Effect of energy, current and absorbed dose

    Energy Technology Data Exchange (ETDEWEB)

    Bakar, Khomsaton Abu; Zulkafli,; Hashim, Siti A' aisah [Malaysian Nuclear Agency (Nuclear Malaysia), Bangi 43000 Kajang Selangor (Malaysia); Ahmad, Pauzi [Universiti Kebangsaan Malaysia, 43600 UKM, Bangi Selangor (Malaysia)

    2014-09-03

    In this study, electron beam accelerator (EB) was used to treat textiles wastewater from Rawang Industrial Park, Selangor. The objectives were to determine effective energy, beam current and absorbed dose required for decoloration and degradation of the textiles effluent. The textiles effluent was irradiated in a batch with various energy of 1MeV to 3MeV at constant beam current of 30mA. It was observed that removal of color and COD increases with higher beam energy. The EB energy of 1MeV effectively to removed 58% color and 19% COD. For textile effluent sample irradiated at fix energy of 1MeV and 3Mev but at different beam current 10mA, 20mA and 30mA. It was observed that removal of color and COD increases with the increased of beam current at each energy. However removal of color was significantly better at 1Mev as compared to 3Mev. In the case of textiles effluent, irradiated at doses of 17, 20,25,30, 35, 100 and 200kGy using 30 kW power of EB (1Mev, 30mA), results shows removal of BOD{sub 5}, COD and color were in the range 9%-33%, 14%-38% and 43%-78% respectively.

  18. A modified beam-to-earth transformation to measure short-wavelength internal waves with an acoustic Doppler current profiler

    Science.gov (United States)

    Scotti, A.; Butman, B.; Beardsley, R.C.; Alexander, P.S.; Anderson, S.

    2005-01-01

    The algorithm used to transform velocity signals from beam coordinates to earth coordinates in an acoustic Doppler current profiler (ADCP) relies on the assumption that the currents are uniform over the horizontal distance separating the beams. This condition may be violated by (nonlinear) internal waves, which can have wavelengths as small as 100-200 m. In this case, the standard algorithm combines velocities measured at different phases of a wave and produces horizontal velocities that increasingly differ from true velocities with distance from the ADCP. Observations made in Massachusetts Bay show that currents measured with a bottom-mounted upward-looking ADCP during periods when short-wavelength internal waves are present differ significantly from currents measured by point current meters, except very close to the instrument. These periods are flagged with high error velocities by the standard ADCP algorithm. In this paper measurements from the four spatially diverging beams and the backscatter intensity signal are used to calculate the propagation direction and celerity of the internal waves. Once this information is known, a modified beam-to-earth transformation that combines appropriately lagged beam measurements can be used to obtain current estimates in earth coordinates that compare well with pointwise measurements. ?? 2005 American Meteorological Society.

  19. Microstructure Analysis of HPb59-1 Brass Induced by High Current Pulsed Electron Beam

    Science.gov (United States)

    Lyu, Jike; Gao, Bo; Hu, Liang; Lu, Shuaidan; Tu, Ganfeng

    2016-08-01

    In this paper, the effects of high current pulsed electron beam (HCPEB) on the microstructure evolution of casting HPb59-1 (Cu 57.1 mass%, Pb 1.7 mass% and Zn balance) alloy were investigated. The results showed a "wavy" surface which was formed with Pb element existing in the forms of stacking block and microparticles on the top surface layer after treatment. Nanocrystalline structures including Pb grains and two phases (α and β) were formed on the top remelted layer and their sizes were all less than 100 nm. The disordered β phase was generated in the surface layer after HCPEB treatment, which is beneficial for the improvement of surface properties. Meanwhile, there was a large residual stress on the alloy surface, along with the appearance of microcracks, and the preferred orientations of grains also changed.

  20. Current status of dental caries diagnosis using cone beam computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Park, Young Seok; Ahn, Jin Soo; Kwon, Ho Beom; Lee, Seung Pyo [School of Dentistry, Seoul National University, Seoul (Korea, Republic of)

    2011-06-15

    The purpose of this article is to review the current status of dental caries diagnosis using cone beam computed tomography (CBCT). An online PubMed search was performed to identify studies on caries research using CBCT. Despite its usefulness, there were inherent limitations in the detection of caries lesions through conventional radiograph mainly due to the two-dimensional (2D) representation of caries lesions. Several efforts were made to investigate the three-dimensional (3D) image of lesion, only to gain little popularity. Recently, CBCT was introduced and has been used for diagnosis of caries in several reports. Some of them maintained the superiority of CBCT systems, however it is still under controversies. The CBCT systems are promising, however they should not be considered as a primary choice of caries diagnosis in everyday practice yet. Further studies under more standardized condition should be performed in the near future.

  1. Obtaining the high-current low-energy electron beams in the systems with a plasma emitter

    CERN Document Server

    Devyatkov, V N; Shchanin, P M

    2001-01-01

    Using gas filled diodes with arc and glow-discharge base plasma emitters one investigated into generation and transfer of high-current electron beams. Using a diode with arc discharge base plasma emitter at 15 kV accelerating voltage one obtained a space charge compensated with up to 1 kA current compressed by proper magnetic field from 8 cm diameter up to 1 cm and transported at over 20 cm distance with 70% efficiency. Using a diode with a glow-discharge one obtained a 80 A current and up to 100 A/cm current density beam. In a weak axial magnetic field with B=0.015 T induction such a beam is transported at 30 cm distance

  2. Effect of longitudinal applied magnetic field on the self-pinched critical current in intense electron beam diode

    Institute of Scientific and Technical Information of China (English)

    Liu Guo-Zhi; Huang Wen-Hua; Shao Hao; Xiao Ren-Zhen

    2006-01-01

    The effect of applied longitudinal magnetic field on the self-pinched critical current in the intense electron beam diode is discussed. The self-pinched critical current is derived and its validity is tested by numerical simulations. The results shows that an applied longitudinal magnetic field tends to increase the self-pinched critical current. Without the effect of anode plasma, the maximal diode current approximately equals the self-pinched critical current with the longitudinal magnetic field applied; when self-pinched occurs, the diode current approaches the self-pinched critical current.

  3. Microstructures and properties of zirconium-702 irradiated by high current pulsed electron beam

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Shen [School of Materials Science and Engineering, Jiangsu University, Zhenjiang 212013 (China); Cai, Jie [School of Materials Science and Engineering, Jiangsu University, Zhenjiang 212013 (China); Engineering Institute of Advanced Manufacturing and Modern Equipment Technology, Jiangsu University, Zhenjiang 212013 (China); Lv, Peng; Zhang, Conglin; Huang, Wei [School of Materials Science and Engineering, Jiangsu University, Zhenjiang 212013 (China); Guan, Qingfeng, E-mail: guanqf@mail.ujs.edu.cn [School of Materials Science and Engineering, Jiangsu University, Zhenjiang 212013 (China)

    2015-09-01

    Highlights: • Zirconium-702 irradiated by high current pulsed electron beam was investigated. • Irradiated surface was melted and martensitic phase transformation occurred. • High density dislocations and deformation twins were formed in melted layer. • Micropores and ultrafine structures were also obtained on the irradiated surface. • Microhardness and corrosion resistance were improved after HCPEB irradiation. - Abstract: The microstructure, hardness and corrosion resistance of zirconium-702 before and after high-current pulsed electron beam (HCPEB) irradiation have been investigated. The microstructure evolution and surface morphologies of the samples were characterized by using X-ray diffraction (XRD), optical microscopy (OM), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The experimental results indicate that the sample surface was melted after HCPEB irradiation, and martensitic phase transformation occurred. Besides, two kinds of craters as well as ultrafine structures were obtained in the melted layer. TEM observations suggest that high density dislocations and deformation twins were formed after HCPEB irradiation. With the increasing of pulses, microhardness of the irradiated samples was increased from the initial 178 Hv to 254 Hv. The corrosion resistance was tested by using electrode impedance spectroscopy (EIS) and potentiodynamic polarization curves. Electrochemical results show that, after HCPEB irradiation, all the samples had better corrosion resistance in 1 mol HNO{sub 3} solution compared to the initial one, among which the 5-pulsed sample owned the best corrosion resistance. Ultrafine structures, martensitic phase transformation, surface porosities, dislocations and deformation twins are believed to be the dominant reasons for the improvement of the hardness and corrosion resistance.

  4. High resolution laser beam induced current images under trichromatic laser radiation: approximation to the solar irradiation.

    Science.gov (United States)

    Navas, F J; Alcántara, R; Fernández-Lorenzo, C; Martín-Calleja, J

    2010-03-01

    A laser beam induced current (LBIC) map of a photoactive surface is a very useful tool when it is necessary to study the spatial variability of properties such as photoconverter efficiency or factors connected with the recombination of carriers. Obtaining high spatial resolution LBIC maps involves irradiating the photoactive surface with a photonic beam with Gaussian power distribution and with a low dispersion coefficient. Laser emission fulfils these characteristics, but against it is the fact that it is highly monochromatic and therefore has a spectral distribution different to solar emissions. This work presents an instrumental system and procedure to obtain high spatial resolution LBIC maps in conditions approximating solar irradiation. The methodology developed consists of a trichromatic irradiation system based on three sources of laser excitation with emission in the red, green, and blue zones of the electromagnetic spectrum. The relative irradiation powers are determined by either solar spectrum distribution or Planck's emission formula which provides information approximate to the behavior of the system if it were under solar irradiation. In turn, an algorithm and a procedure have been developed to be able to form images based on the scans performed by the three lasers, providing information about the photoconverter efficiency of photovoltaic devices under the irradiation conditions used. This system has been checked with three photosensitive devices based on three different technologies: a commercial silicon photodiode, a commercial photoresistor, and a dye-sensitized solar cell. These devices make it possible to check how the superficial quantum efficiency has areas dependent upon the excitation wavelength while it has been possible to measure global incident photon-to-current efficiency values approximating those that would be obtained under irradiation conditions with sunlight.

  5. Design and characterization of the annular cathode high current pulsed electron beam source for circular components

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Wei; Wang, Langping, E-mail: aplpwang@hit.edu.cn; Wang, Xiaofeng

    2016-08-01

    Highlights: • An annular cathode for HCPEB irradiation of circular components was designed. • The processing window for the annular cathode is obtained. • Irradiation thickness uniformity along the circumferential direction exceeds 90%. - Abstract: In order to irradiate circular components with high current pulsed electron beam (HCPEB), an annular cathode based on carbon fiber bunches was designed and fabricated. Using an acceleration voltage of 25 kV, the maximum pulsed irradiation current and energy of this annular cathode can reach 7.9 kA and 300 J, respectively. The irradiation current density distribution of the annular cathode HCPEB source measured along the circumferential direction shows that the annular cathode has good emission uniformity. In addition, four 9310 steel substrates fixed uniformly along the circumferential direction of a metal ring substrate were irradiated by this annular cathode HCPEB source. The surface and cross-section morphologies of the irradiated samples were characterized by scanning electron microscopy (SEM). SEM images of the surface reveal that crater and surface undulation have been formed, which hints that the irradiation energy of the HCPEB process is large enough for surface modification of 9310 steel. Meanwhile, SEM cross-section images exhibit that remelted layers with a thickness of about 5.4 μm have been obtained in all samples, which proves that a good practical irradiation uniformity can be achieved by this annular cathode HCPEB source.

  6. The current status of cone beam computed tomography imaging in orthodontics.

    Science.gov (United States)

    Kapila, S; Conley, R S; Harrell, W E

    2011-01-01

    Cone beam CT (CBCT) has become an increasingly important source of three dimensional (3D) volumetric data in clinical orthodontics since its introduction into dentistry in 1998. The purpose of this manuscript is to highlight the current understanding of, and evidence for, the clinical use of CBCT in orthodontics, and to review the findings to answer clinically relevant questions. Currently available information from studies using CBCT can be organized into five broad categories: 1, the assessment of CBCT technology; 2, its use in craniofacial morphometric analyses; 3, incidental and missed findings; 4, analysis of treatment outcomes; and 5, efficacy of CBCT in diagnosis and treatment planning. The findings in these topical areas are summarized, followed by current indications and protocols for the use of CBCT in specific cases. Despite the increasing popularity of CBCT in orthodontics, and its advantages over routine radiography in specific cases, the effects of information derived from these images in altering diagnosis and treatment decisions has not been demonstrated in several types of cases. It has therefore been recommended that CBCT be used in select cases in which conventional radiography cannot supply satisfactory diagnostic information; these include cleft palate patients, assessment of unerupted tooth position, supernumerary teeth, identification of root resorption and for planning orthognathic surgery. The need to image other types of cases should be made on a case-by-case basis following an assessment of benefits vs risks of scanning in these situations.

  7. The current status of cone beam computed tomography imaging in orthodontics

    Science.gov (United States)

    Kapila, S; Conley, R S; Harrell, W E

    2011-01-01

    Cone beam CT (CBCT) has become an increasingly important source of three dimensional (3D) volumetric data in clinical orthodontics since its introduction into dentistry in 1998. The purpose of this manuscript is to highlight the current understanding of, and evidence for, the clinical use of CBCT in orthodontics, and to review the findings to answer clinically relevant questions. Currently available information from studies using CBCT can be organized into five broad categories: 1, the assessment of CBCT technology; 2, its use in craniofacial morphometric analyses; 3, incidental and missed findings; 4, analysis of treatment outcomes; and 5, efficacy of CBCT in diagnosis and treatment planning. The findings in these topical areas are summarized, followed by current indications and protocols for the use of CBCT in specific cases. Despite the increasing popularity of CBCT in orthodontics, and its advantages over routine radiography in specific cases, the effects of information derived from these images in altering diagnosis and treatment decisions has not been demonstrated in several types of cases. It has therefore been recommended that CBCT be used in select cases in which conventional radiography cannot supply satisfactory diagnostic information; these include cleft palate patients, assessment of unerupted tooth position, supernumerary teeth, identification of root resorption and for planning orthognathic surgery. The need to image other types of cases should be made on a case-by-case basis following an assessment of benefits vs risks of scanning in these situations. PMID:21159912

  8. On the suitability of longitudinal profile measurements using Coherent Smith-Purcell radiation for high current proton beams

    CERN Document Server

    Barros, Joanna; Vieille-Grosjean, Mélissa; Kittelmann, Irena Dolenc; Thomas, Cyrille

    2014-01-01

    The use of Smith-Purcell radiation to measure electrons longitudinal profiles has been demonstrated at several facilities in the picosecond and sub-picosecond range. There is a strong interest for the development of non intercepting longitudinal profile diagnostics for high current proton beams. We present here results of simulations on the expected yield of longitudinal profile monitors using Smith-Purcell radiation for such proton beams.

  9. Gated current integrator for the beam in the RR barrier buckets

    Energy Technology Data Exchange (ETDEWEB)

    A. Cadorn; C. Bhat; J. Crisp

    2003-06-10

    At the Fermilab Recycler Ring (RR), the antiproton (pbar) beam will be stored azimuthally in different segments created by barrier buckets. The beam in each segment may have widely varying intensities. They have developed a gated integrator system to measure the beam intensity in each of the barrier bucket. Here they discuss the design of the system and the results of beam measurements using the integrator.

  10. Generalized Phase Contrast with matched filtering using LCoS pico-projectors

    DEFF Research Database (Denmark)

    Bañas, Andrew Rafael; Palima, Darwin; Glückstad, Jesper

    2012-01-01

    We report a beam shaping system for generating high intensity programmable optical spots using mGPC: matched filtering combined with Generalized Phase Contrast applying two consumer handheld pico-projectors. Such a system presents a low cost alternative for optical trapping and manipulation......, optical lattices and other beam shaping applications usually implemented with high-end spatial light modulators. Portable pico-projectors based on liquid crystal on silicon (LCoS) devices were used as binary phase-only spatial light modulators by setting the appropriate polarization of the illumination...... in these consumer pico-projector LCoS-devices, the mGPC approach tolerates phase aberrations that would have otherwise been contrasted by a standard phase imaging technique....

  11. Influence of gas pressure on electron beam emission current of pulsed cathodic-arc-based forevacuum plasma electron source

    Science.gov (United States)

    Burdovitsin, Victor A.; Kazakov, Andrey V.; Medovnik, Alexander V.; Oks, Efim M.

    2017-09-01

    We describe our experimental investigation of the effect of background gas pressure on the emission parameters of a pulsed cathodic-arc-based forevacuum-pressure plasma-cathode electron source. We find that increased gas pressure over the range 4-16 Pa significantly reduces the beam current rise-time and significantly increases the emission current amplitude. For example, at a discharge current of 20 A, increasing the working gas pressure from 4 Pa to 16 Pa increases the emission current from 8 A to 18 A and shortens the beam rise-time from 50 μs to 20 μs. This influence of gas pressure on the electron beam parameters can be explained by the effect of arc discharge current switching from the anode to emission. In our case, the current switching effect is caused by increased working gas pressure. In the forevacuum pressure range, the increase of the electron emission current with the growth of gas pressure is due to a rise in the emission plasma potential which is caused by ion back-streaming from the plasma formed in the electron beam transport region. A model describing the influence of gas pressure on the electron emission from the plasma is presented.

  12. Production of high current proton beams using complex H-rich molecules at GSI

    Energy Technology Data Exchange (ETDEWEB)

    Adonin, A., E-mail: a.adonin@gsi.de; Barth, W.; Heymach, F.; Hollinger, R.; Vormann, H.; Yakushev, A. [GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt 64291 (Germany)

    2016-02-15

    In this contribution, the concept of production of intense proton beams using molecular heavy ion beams from an ion source is described, as well as the indisputable advantages of this technique for operation of the GSI linear accelerator. The results of experimental investigations, including mass-spectra analysis and beam emittance measurements, with different ion beams (CH{sub 3}{sup +},C{sub 2}H{sub 4}{sup +},C{sub 3}H{sub 7}{sup +}) using various gaseous and liquid substances (methane, ethane, propane, isobutane, and iodoethane) at the ion source are summarized. Further steps to improve the ion source and injector performance with molecular beams are depicted.

  13. Pico meter metrology for the GAIA mission

    NARCIS (Netherlands)

    Meijer, E.A.; Nijenhuis, J.N.; Vink, R.J.P.; Kamphues, F.G.; Gielesen, W.L.M.; Coatantiec, C.

    2009-01-01

    To measure the relative motions of GAIA's telescopes, the angle between the telescopes is monitored by an all Silicon Carbide Basic Angle Monitoring subsystem (BAM OMA). TNO is developing this metrology system. The stability requirements for this metrology system go into the pico meter and pico radi

  14. Demonstration of Current Profile Shaping using Double Dog-Leg Emittance Exchange Beam Line at Argonne Wakefield Accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Ha, Gwanghui [Argonne, HEP; Cho, Moo-Hyun [POSTECH; Conde, Manoel [Argonne, HEP; Doran, Darrell [Argonne, HEP; Gai, Wei [Argonne, HEP; Jing, Chunguang [Euclid Techlabs, Solon; Kim, Kwang-Je [Argonne, HEP; Liu, Wanming [Argonne, HEP; Namkung, Won [POSTECH; Piot, Philippe [Northern Illinois U.; Power, John [Argonne, HEP; Sun, Yin-E [Argonne, HEP; Whiteford, Charles [Argonne, HEP; Wisniewski, Eric [Argonne, HEP; Zholents, Alexander [Argonne, HEP

    2016-06-01

    Emittance exchange (EEX) based longitudinal current profile shaping is the one of the promising current profile shaping technique. This method can generate high quality arbitrary current profiles under the ideal conditions. The double dog-leg EEX beam line was recently installed at the Argonne Wakefield Accelerator (AWA) to explore the shaping capability and confirm the quality of this method. To demonstrate the arbitrary current profile generation, several different transverse masks are applied to generate different final current profiles. The phase space slopes and the charge of incoming beam are varied to observe and suppress the aberrations on the ideal profile. We present current profile shaping results, aberrations on the shaped profile, and its suppression.

  15. Pico: Parameters for the Impatient Cosmologist

    CERN Document Server

    Fendt, W A; Fendt, William A.; Wandelt, Benjamin D.

    2006-01-01

    We present a fast, accurate, robust and flexible method of accelerating parameter estimation. This algorithm, called Pico, can compute the CMB power spectrum and matter transfer function as well as any computationally expensive likelihoods in a few milliseconds. By removing these bottlenecks from parameter estimation codes, Pico decreases their computational time by 1 or 2 orders of magnitude. Pico has several important properties. First, it is extremely fast and accurate over a large volume of parameter space. Furthermore, its accuracy can continue to be improved by using a larger training set. This method is generalizable to an arbitrary number of cosmological parameters and to any range of l-values in multipole space. Pico is approximately 3000 times faster than CAMB for flat models, and approximately 2000 times faster then the WMAP 3 year likelihood code. In this paper, we demonstrate that using Pico to compute power spectra and likelihoods produces parameter posteriors that are very similar to those usin...

  16. Avoiding Program-Induced Cumulative Overload (PICO).

    Science.gov (United States)

    Orr, Robin; Knapik, Joseph J; Pope, Rodney

    2016-01-01

    This article defines the concept of program-induced cumulative overload (PICO), provides examples, and advises ways to mitigate the adverse effects. PICO is the excessive cumulative physical workload that can be imparted to military personnel by a military training program with an embedded physical training component. PICO can be acute (accumulating within a single day) or chronic (accumulating across the entirety of the program) and results in adverse outcomes for affected personnel, including detrimental fatigue, performance degradation, injuries, or illness. Strategies to mitigate PICO include focusing administration and logistic practices during the development and ongoing management of a trainee program and implementing known musculoskeletal injury prevention strategies. More training is not always better, and trainers need to consider the total amount of physical activity that military personnel experience across both operational training and physical training if PICO is to be mitigated.

  17. Use of cone beam computed tomography in implant dentistry: current concepts, indications and limitations for clinical practice and research.

    Science.gov (United States)

    Bornstein, Michael M; Horner, Keith; Jacobs, Reinhilde

    2017-02-01

    Diagnostic radiology is an essential component of treatment planning in the field of implant dentistry. This narrative review will present current concepts for the use of cone beam computed tomography imaging, before and after implant placement, in daily clinical practice and research. Guidelines for the selection of three-dimensional imaging will be discussed, and limitations will be highlighted. Current concepts of radiation dose optimization, including novel imaging modalities using low-dose protocols, will be presented. For preoperative cross-sectional imaging, data are still not available which demonstrate that cone beam computed tomography results in fewer intraoperative complications such as nerve damage or bleeding incidents, or that implants inserted using preoperative cone beam computed tomography data sets for planning purposes will exhibit higher survival or success rates. The use of cone beam computed tomography following the insertion of dental implants should be restricted to specific postoperative complications, such as damage of neurovascular structures or postoperative infections in relation to the maxillary sinus. Regarding peri-implantitis, the diagnosis and severity of the disease should be evaluated primarily based on clinical parameters and on radiological findings based on periapical radiographs (two dimensional). The use of cone beam computed tomography scans in clinical research might not yield any evident beneficial effect for the patient included. As many of the cone beam computed tomography scans performed for research have no direct therapeutic consequence, dose optimization measures should be implemented by using appropriate exposure parameters and by reducing the field of view to the actual region of interest.

  18. An iterative algorithm for determining depth profiles of collection probability by electron-beam-induced current

    Science.gov (United States)

    Konovalov, Igor; Breitenstein, Otwin

    2001-01-01

    An iterative algorithm for the derivation of depth profiles of the minority carrier collection probability in a semiconductor with or without a coating on the top is presented using energy-resolved electron-beam-induced current measurements in planar geometry. The calculation is based on the depth-dose function of Everhart and Hoff (Everhart T E and Hoff P H 1971 J. Appl. Phys. 42 5837) and on the penetration-range function of Kanaya and Okayama (Kanaya K and Okayama S 1972 J. Phys. D: Appl. Phys. 5 43) or on that of Fitting (Fitting H-J 1974 Phys. Status Solidi/ a 26 525). It can also be performed with any other depth-dose functions. Using this algorithm does not require us to make any assumptions on the shape of the collection profile within the depth of interest. The influence of an absorbing top contact and/or a limited thickness of the semiconductor layer appear in the result, but can also be taken explicitly into account. Examples using silicon and CIS solar cells as well as a GaAs LED are presented.

  19. High-current electron beam generation in a diode with a multicapillary dielectric cathode

    Science.gov (United States)

    Gleizer, J. Z.; Hadas, Y.; Gurovich, V. Tz.; Felsteiner, J.; Krasik, Ya. E.

    2008-02-01

    Results of high-current electron beam generation in an ˜200kV, ˜250ns diode with a multicapillary dielectric cathode (MCDC) assisted by either velvet-type or ferroelectric plasma sources (FPSs) are presented. Multicapillary cathodes made of cordierite, glass, and quartz glass samples were studied. It was found that the source of electrons is the plasma ejected from capillaries. The plasma parameters inside capillary channels and in the vicinity of the cathode surface were determined during the accelerating pulse using visible range spectroscopy. It was shown that glass multicapillary cathodes are characterized by less surface erosion than the cordierite cathodes. Also, it was found that multicapillary cathodes assisted by a FPS showed longer lifetime and better vacuum compatibility than multicapillary cathodes assisted by a velvet-type igniter. Finally, it was found that quartz glass MCDC assisted by FPS is characterized by almost simultaneous formation of the plasma in a cross-sectional area of the dielectric sample with respect to the beginning of the accelerating pulse. The latter is explained by intense UV radiation which synchronized formation of parallel discharges due to induced secondary electron emission.

  20. Experimental Estimating Deflection of a Simple Beam Bridge Model Using Grating Eddy Current Sensors

    Directory of Open Access Journals (Sweden)

    Hui Zhao

    2012-07-01

    Full Text Available A novel three-point method using a grating eddy current absolute position sensor (GECS for bridge deflection estimation is proposed in this paper. Real spatial positions of the measuring points along the span axis are directly used as relative reference points of each other rather than using any other auxiliary static reference points for measuring devices in a conventional method. Every three adjacent measuring points are defined as a measuring unit and a straight connecting bar with a GECS fixed on the center section of it links the two endpoints. In each measuring unit, the displacement of the mid-measuring point relative to the connecting bar measured by the GECS is defined as the relative deflection. Absolute deflections of each measuring point can be calculated from the relative deflections of all the measuring units directly without any correcting approaches. Principles of the three-point method and displacement measurement of the GECS are introduced in detail. Both static and dynamic experiments have been carried out on a simple beam bridge model, which demonstrate that the three-point deflection estimation method using the GECS is effective and offers a reliable way for bridge deflection estimation, especially for long-term monitoring.

  1. Surface Modification of Light Alloys by Low-Energy High-Current Pulsed Electron Beam

    Directory of Open Access Journals (Sweden)

    X. D. Zhang

    2012-01-01

    Full Text Available This paper reviews results obtained by the research groups developing the low-energy high-current pulsed electron beam (LEHCPEB in Dalian (China and Metz (France on the surface treatment of light alloys. The pulsed electron irradiation induces an ultra-fast thermal cycle at the surface combined with the formation of thermal stress and shock waves. As illustrated for Mg alloys and Ti, this results in deep subsurface hardening (over several 100 μm which improves the wear resistance. The analysis of the top surface melted surface of light alloys also often witnesses evaporation and condensation of chemical species. This phenomenon can significantly modify the melt chemistry and was also suggested to lead to the development of specific solidification textures in the rapidly solidified layer. The potential use of the LEHCPEB technique for producing thermomechanical treatments under the so-called heating mode and, thus, modify the surface crystallographic texture, and enhance solid-state diffusion is also demonstrated in the case of the FeAl intermetallic compound.

  2. Study on Nanostructures Induced by High-Current Pulsed Electron Beam

    Directory of Open Access Journals (Sweden)

    Bo Gao

    2012-01-01

    Full Text Available Four techniques using high-current pulsed electron beam (HCPEB were proposed to obtain surface nanostructure of metal and alloys. The first method involves the distribution of several fine Mg nanoparticles on the top surface of treated samples by evaporation of pure Mg with low boiling point. The second technique uses superfast heating, melting, and cooling induced by HCPEB irradiation to refine the primary phase or the second phase in alloys to nanosized uniform distributed phases in the matrix, such as the quasicrystal phase Mg30Zn60Y10 in the quasicrystal alloy Mg67Zn30Y3. The third technique involves the refinement of eutectic silicon phase in hypereutectic Al-15Si alloys to fine particles with the size of several nanometers through solid solution and precipitation refinement. Finally, in the deformation zone induced by HCPEB irradiation, the grain size can be refined to several hundred nanometers, such as the grain size of the hypereutectic Al-15Si alloys in the deformation zone, which can reach ~400 nm after HCPEB treatment for 25 pulses. Therefore, HCPEB technology is an efficient way to obtain surface nanostructure.

  3. Microstructures and properties of zirconium-702 irradiated by high current pulsed electron beam

    Science.gov (United States)

    Yang, Shen; Cai, Jie; Lv, Peng; Zhang, Conglin; Huang, Wei; Guan, Qingfeng

    2015-09-01

    The microstructure, hardness and corrosion resistance of zirconium-702 before and after high-current pulsed electron beam (HCPEB) irradiation have been investigated. The microstructure evolution and surface morphologies of the samples were characterized by using X-ray diffraction (XRD), optical microscopy (OM), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The experimental results indicate that the sample surface was melted after HCPEB irradiation, and martensitic phase transformation occurred. Besides, two kinds of craters as well as ultrafine structures were obtained in the melted layer. TEM observations suggest that high density dislocations and deformation twins were formed after HCPEB irradiation. With the increasing of pulses, microhardness of the irradiated samples was increased from the initial 178 Hv to 254 Hv. The corrosion resistance was tested by using electrode impedance spectroscopy (EIS) and potentiodynamic polarization curves. Electrochemical results show that, after HCPEB irradiation, all the samples had better corrosion resistance in 1 mol HNO3 solution compared to the initial one, among which the 5-pulsed sample owned the best corrosion resistance. Ultrafine structures, martensitic phase transformation, surface porosities, dislocations and deformation twins are believed to be the dominant reasons for the improvement of the hardness and corrosion resistance.

  4. Revisiting cAMP signaling in the carotid body

    Directory of Open Access Journals (Sweden)

    Ana Rita eNunes

    2014-10-01

    Full Text Available Chronic carotid body (CB activation is now recognized as being essential in the development of hypertension and promoting insulin resistance; thus, it is imperative to characterize the chemotransduction mechanisms of this organ in order to modulate its activity and improve patient outcomes. For several years, and although controversial, cyclic adenosine monophosphate (cAMP was considered an important player in initiating the activation of the CB. However, its relevance was partially displaced in the 90s by the emerging role of the mitochondria and molecules such as AMP-activated protein kinase (AMPK and O2-sensitive K+ channels. Neurotransmitters/neuromodulators binding to metabotropic receptors are essential to chemotransmission in the CB, and cAMP is central to this process. cAMP also contributes to raise intracellular Ca2+ levels, and is intimately related to the cellular energetic status (AMP/ATP ratio. Furthermore, cAMP signaling is a target of multiple current pharmacological agents used in clinical practice. This review provides an outline on 1 the classical view of the cAMP-signaling pathway in the CB that originally supported its role in the O2/CO2 sensing mechanism, 2 present recent evidence on CB cAMP neuromodulation and 3 discuss how CB activity is affected by current clinical therapies that modify cAMP-signaling, namely dopaminergic drugs, caffeine (modulation of A2A/A2B receptors and roflumilast (PDE4 inhibitors. cAMP is key to any process that involves metabotropic receptors and the intracellular pathways involved in CB disease states are likely to involve this classical second messenger. Research examining the potential modification of cAMP levels and/or interactions with molecules associated with CB hyperactivity is currently in its beginning and this review will open doors for future explorations.

  5. Measurement of charged current deep inelastic scattering cross sections with a longitudinally polarised electron beam at HERA

    NARCIS (Netherlands)

    Chekanov, S.; Derrick, M.; Magill, S.; Musgrave, B.; Nicholass, D.; Repond, J.; Yoshida, R.; Mattingly, M. C. K.; Antonioli, P.; Bari, G.; Bellagamba, L.; Boscherini, D.; Bruni, A.; Bruni, G.; Cindolo, F.; Corradi, M.; Iacobucci, G.; Margotti, A.; Nania, R.; Polini, A.; Antonelli, S.; Basile, M.; Bindi, M.; Cifarelli, L.; Contin, A.; Pasquale, S. De; Sartorelli, G.; Zichichi, A.; Bartsch, D.; Brock, I.; Hartmann, H.; Hilger, E.; Jakob, H.-P.; Jungst, M.; Nuncio-Quiroz, A. E.; Samson, U.; Schonberg, V.; Shehzadi, R.; Wlasenko, M.; Brook, N. H.; Heath, G. P.; Kaur, M.; Kaur, P.; Singh, I.; Capua, M.; Fazio, S.; Mastroberardino, A.; Schioppa, M.; Susinno, G.; Tassi, E.; Kim, J. Y.; Ibrahim, Z. A.; Mohamad Idris, F.; Kamaluddin, B.; Wan Abdullah, W. A. T.; Ning, Y.; Ren, Z.; Sciulli, F.; Chwastowski, J.; Eskreys, A.; Figiel, J.; Galas, A.; Olkiewicz, K.; Pawlik, B.; Stopa, P.; Zawiejski, L.; Adamczyk, L.; Bold, T.; Grabowska-Bold, I.; Kisielewska, D.; Lukasik, J.; Przybycien, M.; Suszycki, L.; Kotanski, A.; Slominski, W.; Behnke, O.; Behrens, U.; Blohm, C.; Bonato, A.; Borras, K.; Ciesielski, R.; Coppola, N.; Fourletova, J.; Geiser, A.; Gottlicher, P.; Grebenyuk, J.; Gregor, I.; Haas, T.; Hain, W.; Huttmann, A.; Januschek, F.; Kahle, B.; Katkov, I. I.; Klein, U.; Kotz, U.; Kowalski, H.; Lisovyi, M.; Lobodzinska, E.; Lohr, B.; Mankel, R.; Melzer-Pellmann, I.-A.; Miglioranzi, S.; Montanari, A.; Namsoo, T.; Notz, D.; Parenti, A.; Rinaldi, L.; Roloff, P.; Rubinsky, I.; Schneekloth, U.; Spiridonov, A.; Szuba, D.; Szuba, J.; Theedt, T.; Ukleja, J.; Wolf, G.; Wrona, K.; Yagues Molina, A. G.; Youngman, C.; Zeuner, W.; Drugakov, V.; Lohmann, W.; Schlenstedt, S.; Barbagli, G.; Gallo, E.; Pelfer, P. G.; Bamberger, A.; Dobur, D.; Karstens, F.; Vlasov, N. N.; Bussey, P. J.; Doyle, A. T.; Dunne, W.; Forrest, M.; Rosin, M.; Saxon, D. H.; Skillicorn, I. O.; Gialas, I.; Papageorgiu, K.; Holm, U.; Klanner, R.; Lohrmann, E.; Perrey, H.; Schleper, P.; Schorner-Sadenius, T.; Sztuk, J.; Stadie, H.; Turcato, M.; Foudas, C.; Fry, C.; Long, K. R.; Tapper, A. D.; Matsumoto, T.; Nagano, K.; Tokushuku, K.; Yamada, S.; Yamazaki, Y.; Barakbaev, A. N.; Boos, E. G.; Pokrovskiy, N. S.; Zhautykov, B. O.; Aushev, V.; Bachynska, O.; Borodin, M.; Kadenko, I.; Kozulia, A.; Libov, V.; Lontkovskyi, D.; Makarenko, I.; Sorokin, Iu.; Verbytskyi, A.; Volynets, O.; Son, D.; de Favereau, J.; Piotrzkowski, K.; Barreiro, F.; Glasman, C.; Jimenez, M.; Labarga, L.; del Peso, J.; Ron, E.; Soares, M.; Terron, J.; Uribe-Estrada, C.; Zambrana, M.; Corriveau, F.; Schwartz, J.; Walsh, R.; Tsurugai, T.; Antonov, A.; Dolgoshein, B. A.; Gladkov, D.; Sosnovtsev, V.; Stifutkin, A.; Suchkov, S.; Dementiev, R. K.; Ermolov, P. F.; Gladilin, L. K.; Golubkov, Yu. A.; Khein, L. A.; Korzhavina, I. A.; Kuzmin, V. A.; Levchenko, B. B.; Lukina, O. Yu.; Proskuryakov, A. S.; Shcheglova, L. M.; Zotkin, D. S.; Abt, I.; Caldwell, A.; Kollar, D.; Reisert, B.; Schmidke, W. B.; Grigorescu, G.; Keramidas, A.; Kooijman, P.; Pellegrino, A.; Tiecke, H.; Vazquez, M.; Brummer, N.; Bylsma, B.; Durkin, L. S.; Lee, A.; Ling, T. Y.; Allfrey, P. D.; Bell, M. A.; Cooper-Sarkar, A. M.; Devenish, R. C. E.; Ferrando, J.; Foster, B.; Gwenlan, C.; Horton, K.; Oliver, K.; Robertson, A.; Walczak, R.; Bertolin, A.; Dal Corso, F.; Dusini, S.; Longhin, A.; Stanco, L.; Bellan, P.; Brugnera, R.; Carlin, R.; Garfagnini, A.; Limentani, S.; Oh, B. Y.; Raval, A.; Whitmore, J. J.; Iga, Y.; D'Agostini, G.; Marini, G.; Nigro, A.; Cole, J. E.; Hart, J. C.; Abramowicz, H.; Ingbir, R.; Kananov, S.; Stern, A.; Kuze, M.; Maeda, J.; Hori, R.; Kagawa, S.; Okazaki, N.; Tawara, T.; Hamatsu, R.; Kaji, H.; Kitamura, S.; Ota, O.; Ri, Y. D.; Costa, M.; Ferrero, M. I.; Monaco, V.; Sacchi, R.; Sola, V.; Solano, A.; Arneodo, M.; Ruspa, M.; Fourletov, S.; Stewart, T. P.; Boutle, S. K.; Butterworth, J. M.; Jones, T. W.; Loizides, J. H.; Wing, M.; Brzozowska, B.; Ciborowski, J.; Grzelak, G.; Kulinski, P.; Luzniak, P.; Malka, J.; Nowak, R. J.; Pawlak, J. M.; Perlanski, W.; Tymieniecka, T.; Zarnecki, A. F.; Adamus, M.; Plucinski, P.; Ukleja, A.; Eisenberg, Y.; Hochman, D.; Karshon, U.; Brownson, E.; Reeder, D. D.; Savin, A. A.; Smith, W. H.; Wolfe, H.; Bhadra, S.; Catterall, C. D.; Hartner, G.; Menary, S.; Noor, U.; Standage, J.; Whyte, J.

    2009-01-01

    Measurements of the cross sections for charged current deep inelastic scattering in e(-)p collisions with longitudinally polarised electron beams are presented. The measurements are based on a data sample with an integrated luminosity of 175 pb(-1) collected with the ZEUS detector at HERA at a centr

  6. Study on the effect of welding current during laser beam-resistance seam welding of aluminum alloy 5052

    Institute of Scientific and Technical Information of China (English)

    Li Yongqiang; Zhao Xihua; Zhao He; Cao Haipeng; Zhao Huanling

    2008-01-01

    The effect of welding current on the weld shape and tensile shear load during laser beam-resistance seam welding (LB-RSW) of aluminum alloy 5052 is studied. Experimental results show that the penetration depth, weld width,tensile shear load and the ratio of penetration depth to weld width of LB-RSW are bigger than those of laser beam welding(LBW) under the same conditions and the former three parameters increase as welding current rises. The weld shape of LB-RSW below 5 kA welding current is nearly the same as that of LBW. The weld morphology is protuberant under the condition of 5 kA welding current and 0.8 m/min welding speed. Furthermore, the microstructure of the weld seam of LB-RSW is coarser than that of LBW.

  7. Wideband current transformers for the surveillance of the beam extraction kicker system of the Large Hadron Collider

    CERN Document Server

    Defrance, C; Ducimetière, L; Vossenberg, E

    2007-01-01

    The LHC beam dumping system must protect the LHC machine from damage by reliably and safely extracting and absorbing the circulating beams when requested. Two sets of 15 extraction kicker magnets form the main active part of this system. A separate high voltage pulse generator powers each magnet. Because of the high beam energy and the consequences which could result from significant beam loss due to a malfunctioning of the dump system the magnets and generators are continuously surveyed in order to generate a beam abort as soon as an internal fault is detected. Amongst these surveillance systems, wideband current transformers have been designed to detect any erratic start in one of the generators. Output power should be enough to directly re-trigger all the power trigger units of the remaining 14 generators. The current transformers were developed in collaboration with industry. To minimize losses, high-resistivity cobalt alloy was chosen for the cores. The annealing techniques originally developed for LEP b...

  8. Investigations of Beam Dynamics Issues at Current and Future Hadron Accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Ellison, James [Univ. of New Mexico, Albuquerque, NM (United States); Lau, Stephen [Univ. of New Mexico, Albuquerque, NM (United States); Heinemann, Klaus [Univ. of New Mexico, Albuquerque, NM (United States); Bizzozero, David [Univ. of New Mexico, Albuquerque, NM (United States)

    2015-03-12

    Final Report Abstract for DE-FG02-99ER4110, May 15, 2011- October 15, 2014 There is a synergy between the fields of Beam Dynamics (BD) in modern particle accelerators and Applied Mathematics (AMa). We have formulated significant problems in BD and have developed and applied tools within the contexts of dynamical systems, topological methods, numerical analysis and scientific computing, probability and stochastic processes, and mathematical statistics. We summarize the three main areas of our AMa work since 2011. First, we continued our study of Vlasov-Maxwell systems. Previously, we developed a state of the art algorithm and code (VM3@A) to calculate coherent synchrotron radiation in single pass systems. In this cycle we carefully analyzed the major expense, namely the integral-over-history (IOH), and developed two approaches to speed up integration. The first strategy uses a representation of the Bessel function J0 in terms of exponentials. The second relies on “local sequences” developed recently for radiation boundary conditions, which are used to reduce computational domains. Although motivated by practicality, both strategies involve interesting and rather deep analysis and approximation theory. As an alternative to VM3@A, we are integrating Maxwell’s equations by a time-stepping method, bypass- ing the IOH, using a Discontinuous Galerkin (DG) method. DG is a generalization of Finite Element and Finite Volume methods. It is spectrally convergent, unlike the commonly used Finite Difference methods, and can handle complicated vacuum chamber geometries. We have applied this in several contexts and have obtained very nice results including an explanation of an experiment at the Canadian Light Source, where the geometry is quite complex. Second, we continued our study of spin dynamics in storage rings. There is much current and proposed activity where spin polarized beams are being used in testing the Standard Model and its modifications. Our work has focused

  9. Investigation of chemical vapour deposition diamond detectors by X- ray micro-beam induced current and X-ray micro-beam induced luminescence techniques

    CERN Document Server

    Olivero, P; Vittone, E; Fizzotti, F; Paolini, C; Lo Giudice, A; Barrett, R; Tucoulou, R

    2004-01-01

    Tracking detectors have become an important ingredient in high-energy physics experiments. In order to survive the harsh detection environment of the Large Hadron Collider (LHC), trackers need to have special properties. They must be radiation hard, provide fast collection of charge, be as thin as possible and remove heat from readout electronics. The unique properties of diamond allow it to fulfill these requirements. In this work we present an investigation of the charge transport and luminescence properties of "detector grade" artificial chemical vapour deposition (CVD) diamond devices developed within the CERN RD42 collaboration, performed by means of X-ray micro-beam induced current collection (XBICC) and X-ray micro- beam induced luminescence (XBIL) techniques. XBICC technique allows quantitative estimates of the transport parameters of the material to be evaluated and mapped with micrometric spatial resolution. In particular, the high resolution and sensitivity of the technique has allowed a quantitati...

  10. High-current CW beam profile monitors using transition radiation at CEBAF

    Science.gov (United States)

    Piot, P.; Denard, J.-C.; Adderley, P.; Capek, K.; Feldl, E.

    1997-01-01

    One way of measuring the profile of CEBAF's low-emittance, high-power beam is to use the optical transition radiation (OTR) emitted from a thin foil surface when the electron beam passes through it. We present the design of a monitor using the forward OTR emitted from a 0.25-μm carbon foil. We believe that the monitor will resolve three main issues: i) whether the maximum temperature of the foil stays below the melting point, ii) whether the beam loss remains below 0.5%, in order not to trigger the machine protection system, and iii) whether the monitor resolution (unlike that of synchrotron radiation monitors) is better than the product λγ. It seems that the most serious limitation for CEBAF is the beam loss due to beam scattering. We present results from Keil's theory and simulations from the computer code GEANT as well as measurements with aluminum foils with a 45-MeV electron beam. We also present a measurement of a 3.2-GeV beam profile that is much smaller than λγ, supporting Rule and Fiorito's calculations of the OTR resolution limit due to diffraction.

  11. Basis for low beam loss in the high-current APT linac

    Energy Technology Data Exchange (ETDEWEB)

    Wangler, T.P.; Gray, E.R.; Krawczyk, F.L.; Kurennoy, S.S.; Lawrence, G.P.; Ryne, R.D. [Los Alamos National Lab., NM (United States); Crandall, K.R. [TECHSOURCE, Santa Fe, NM (United States)

    1998-12-31

    The present evidence that the APT proton linac design will meet its goal of low beam loss operation. The conclusion has three main bases: (1) extrapolation from the understanding of the performance of the 800-MeV LANSCE proton linac at Los Alamos, (2) the theoretical understanding of the dominant halo-forming mechanism in the APT accelerator from physics models and multiparticle simulations, and (3) the conservative approach and key principles underlying the design of the APT linac, which are aimed at minimizing beam halo and providing large apertures to reduce beam loss to a very low value.

  12. Clinical utility of dental cone-beam computed tomography: current perspectives

    Directory of Open Access Journals (Sweden)

    Jaju PP

    2014-04-01

    Full Text Available Prashant P Jaju,1 Sushma P Jaju21Oral Medicine and Radiology, 2Conservative Dentistry and Endodontics, Rishiraj College of Dental Sciences and Research Center, Bhopal, IndiaAbstract: Panoramic radiography and computed tomography were the pillars of maxillofacial diagnosis. With the advent of cone-beam computed tomography, dental practice has seen a paradigm shift. This review article highlights the potential applications of cone-beam computed tomography in the fields of dental implantology and forensic dentistry, and its limitations in maxillofacial diagnosis.Keywords: dental implants, cone-beam computed tomography, panoramic radiography, computed tomography

  13. Preliminary results concerning the simulation of beam profiles from extracted ion current distributions for mini-STRIKE

    Energy Technology Data Exchange (ETDEWEB)

    Agostinetti, P., E-mail: piero.agostinetti@igi.cnr.it; Serianni, G.; Veltri, P. [Consorzio RFX (CNR, ENEA, INFN, Università di Padova, Acciaierie Venete SpA), Corso Stati Uniti 4, 35127 Padova (Italy); Giacomin, M. [Physics Department, Università di Padova, via F. Marzolo 8, 35131 Padova (Italy); Bonomo, F.; Schiesko, L. [Max-Planck-Institut für Plasmaphysik, Boltzmannstrasse 2, D-85748 Garching (Germany)

    2016-02-15

    The Radio Frequency (RF) negative hydrogen ion source prototype has been chosen for the ITER neutral beam injectors due to its optimal performances and easier maintenance demonstrated at Max-Planck-Institut für Plasmaphysik, Garching in hydrogen and deuterium. One of the key information to better understand the operating behavior of the RF ion sources is the extracted negative ion current density distribution. This distribution—influenced by several factors like source geometry, particle drifts inside the source, cesium distribution, and layout of cesium ovens—is not straightforward to be evaluated. The main outcome of the present contribution is the development of a minimization method to estimate the extracted current distribution using the footprint of the beam recorded with mini-STRIKE (Short-Time Retractable Instrumented Kalorimeter). To accomplish this, a series of four computational models have been set up, where the output of a model is the input of the following one. These models compute the optics of the ion beam, evaluate the distribution of the heat deposited on the mini-STRIKE diagnostic calorimeter, and finally give an estimate of the temperature distribution on the back of mini-STRIKE. Several iterations with different extracted current profiles are necessary to give an estimate of the profile most compatible with the experimental data. A first test of the application of the method to the BAvarian Test Machine for Negative ions beam is given.

  14. picoArray Technology: The Tool's Story

    CERN Document Server

    Duller, Andrew; Panesar, Gajinder; Gray, Alan; Robbins, Will

    2011-01-01

    This paper briefly describes the picoArray? architecture, and in particular the deterministic internal communication fabric. The methods that have been developed for debugging and verifying systems using devices from the picoArray family are explained. In order to maximize the computational ability of these devices, hardware debugging support has been kept to a minimum and the methods and tools developed to take this into account.

  15. Comparison of three different concepts of high dynamic range and dependability optimised current measurement digitisers for beam loss systems

    CERN Document Server

    Viganò, W; Effinger, E; Venturini, G G; Zamantzas, C

    2012-01-01

    Three Different Concepts of High Dynamic Range and Dependability Optimised Current Measurement Digitisers for Beam Loss Systems will be compared on this paper. The first concept is based on Current to Frequency Conversion, enhanced with an ADC for extending the dynamic range and decreasing the response time. A summary of 3 years’ worth of operational experience with such a system for LHC beam loss monitoring will be given. The second principle is based on an Adaptive Current to Frequency Converter implemented in an ASIC. The basic parameters of the circuit are discussed and compared with measurements. Several measures are taken to harden both circuits against single event effects and to make them tolerant for operation in radioactive environments. The third circuit is based on a Fully Differential Integrator for enhanced dynamic range, where laboratory and test installation measurements will be presented. All circuits are designed to avoid any dead time in the acquisition and have reliability and fail safe...

  16. The edge transient-current technique (E-TCT) with high energy hadron beam

    Science.gov (United States)

    Gorišek, Andrej; Cindro, Vladimir; Kramberger, Gregor; Mandić, Igor; Mikuž, Marko; Muškinja, Miha; Zavrtanik, Marko

    2016-09-01

    We propose a novel way to investigate the properties of silicon and CVD diamond detectors for High Energy Physics experiments complementary to the already well-established E-TCT technique using laser beam. In the proposed setup the beam of high energy hadrons (MIPs) is used instead of laser beam. MIPs incident on the detector in the direction parallel to the readout electrode plane and perpendicular to the edge of the detector. Such experiment could prove very useful to study CVD diamond detectors that are almost inaccessible for the E-TCT measurements with laser due to large band-gap as well as to verify and complement the E-TCT measurements of silicon. The method proposed is being tested at CERN in a beam of 120 GeV hadrons using a reference telescope with track resolution at the DUT of few μm. The preliminary results of the measurements are presented.

  17. The edge transient-current technique (E-TCT) with high energy hadron beam

    Energy Technology Data Exchange (ETDEWEB)

    Gorišek, Andrej; Cindro, Vladimir; Kramberger, Gregor; Mandić, Igor [J. Stefan Institute, Ljubljana (Slovenia); Mikuž, Marko [J. Stefan Institute, Ljubljana (Slovenia); University of Ljubljana (Slovenia); Muškinja, Miha; Zavrtanik, Marko [J. Stefan Institute, Ljubljana (Slovenia)

    2016-09-21

    We propose a novel way to investigate the properties of silicon and CVD diamond detectors for High Energy Physics experiments complementary to the already well-established E-TCT technique using laser beam. In the proposed setup the beam of high energy hadrons (MIPs) is used instead of laser beam. MIPs incident on the detector in the direction parallel to the readout electrode plane and perpendicular to the edge of the detector. Such experiment could prove very useful to study CVD diamond detectors that are almost inaccessible for the E-TCT measurements with laser due to large band-gap as well as to verify and complement the E-TCT measurements of silicon. The method proposed is being tested at CERN in a beam of 120 GeV hadrons using a reference telescope with track resolution at the DUT of few μm. The preliminary results of the measurements are presented.

  18. Combining classifiers for robust PICO element detection

    Directory of Open Access Journals (Sweden)

    Grad Roland

    2010-05-01

    Full Text Available Abstract Background Formulating a clinical information need in terms of the four atomic parts which are Population/Problem, Intervention, Comparison and Outcome (known as PICO elements facilitates searching for a precise answer within a large medical citation database. However, using PICO defined items in the information retrieval process requires a search engine to be able to detect and index PICO elements in the collection in order for the system to retrieve relevant documents. Methods In this study, we tested multiple supervised classification algorithms and their combinations for detecting PICO elements within medical abstracts. Using the structural descriptors that are embedded in some medical abstracts, we have automatically gathered large training/testing data sets for each PICO element. Results Combining multiple classifiers using a weighted linear combination of their prediction scores achieves promising results with an f-measure score of 86.3% for P, 67% for I and 56.6% for O. Conclusions Our experiments on the identification of PICO elements showed that the task is very challenging. Nevertheless, the performance achieved by our identification method is competitive with previously published results and shows that this task can be achieved with a high accuracy for the P element but lower ones for I and O elements.

  19. Investigations of Beam Dynamics Issues at Current and Future Hadron Accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Ellison, James [Univ. of New Mexico, Albuquerque, NM (United States); Lau, Stephen [Univ. of New Mexico, Albuquerque, NM (United States); Heinemann, Klaus [Univ. of New Mexico, Albuquerque, NM (United States); Bizzozero, David [Univ. of New Mexico, Albuquerque, NM (United States)

    2015-03-12

    Final Report Abstract for DE-FG02-99ER4110, May 15, 2011- October 15, 2014 There is a synergy between the fields of Beam Dynamics (BD) in modern particle accelerators and Applied Mathematics (AMa). We have formulated significant problems in BD and have developed and applied tools within the contexts of dynamical systems, topological methods, numerical analysis and scientific computing, probability and stochastic processes, and mathematical statistics. We summarize the three main areas of our AMa work since 2011. First, we continued our study of Vlasov-Maxwell systems. Previously, we developed a state of the art algorithm and code (VM3@A) to calculate coherent synchrotron radiation in single pass systems. In this cycle we carefully analyzed the major expense, namely the integral-over-history (IOH), and developed two approaches to speed up integration. The first strategy uses a representation of the Bessel function J0 in terms of exponentials. The second relies on “local sequences” developed recently for radiation boundary conditions, which are used to reduce computational domains. Although motivated by practicality, both strategies involve interesting and rather deep analysis and approximation theory. As an alternative to VM3@A, we are integrating Maxwell’s equations by a time-stepping method, bypass- ing the IOH, using a Discontinuous Galerkin (DG) method. DG is a generalization of Finite Element and Finite Volume methods. It is spectrally convergent, unlike the commonly used Finite Difference methods, and can handle complicated vacuum chamber geometries. We have applied this in several contexts and have obtained very nice results including an explanation of an experiment at the Canadian Light Source, where the geometry is quite complex. Second, we continued our study of spin dynamics in storage rings. There is much current and proposed activity where spin polarized beams are being used in testing the Standard Model and its modifications. Our work has focused

  20. Measurement of neutral current neutral pion production on Carbon in a Few-GeV Neutrino Beam

    CERN Document Server

    Kurimoto, Y

    2009-01-01

    The SciBooNE Collaboration has measured neutral current neutral pion production by the muon neutrino beam at a polystyrene target (C8H8). We obtained (7.7+- 0.5(stat.)+0.4-0.5 (sys.)) x 10^-2 as cross section ratio of the neutral current neutral pion production to total charged current cross section at the mean neutrino energy of 1.16 GeV. This result is consistent with the Monte Carlo prediction based on the Rein-Sehgal model

  1. The structure and properties of boron carbide ceramics modified by high-current pulsed electron-beam

    Science.gov (United States)

    Ivanov, Yuri; Tolkachev, Oleg; Petyukevich, Maria; Teresov, Anton; Ivanova, Olga; Ikonnikova, Irina; Polisadova, Valentina

    2016-01-01

    The present work is devoted to numerical simulation of temperature fields and the analysis of structural and strength properties of the samples surface layer of boron carbide ceramics treated by the high-current pulsed electron-beam of the submillisecond duration. The samples made of sintered boron carbide ceramics are used in these investigations. The problem of calculating the temperature field is reduced to solving the thermal conductivity equation. The electron beam density ranges between 8…30 J/cm2, while the pulse durations are 100…200 μs in numerical modelling. The results of modelling the temperature field allowed ascertaining the threshold parameters of the electron beam, such as energy density and pulse duration. The electron beam irradiation is accompanied by the structural modification of the surface layer of boron carbide ceramics either in the single-phase (liquid or solid) or two-phase (solid-liquid) states. The sample surface of boron carbide ceramics is treated under the two-phase state (solid-liquid) conditions of the structural modification. The surface layer is modified by the high-current pulsed electron-beam produced by SOLO installation at the Institute of High Current Electronics of the Siberian Branch of the Russian Academy of Sciences, Tomsk, Russia. The elemental composition and the defect structure of the modified surface layer are analyzed by the optical instrument, scanning electron and transmission electron microscopes. Mechanical properties of the modified layer are determined measuring its hardness and crack resistance. Research results show that the melting and subsequent rapid solidification of the surface layer lead to such phenomena as fragmentation due to a crack network, grain size reduction, formation of the sub-grained structure due to mechanical twinning, and increase of hardness and crack resistance.

  2. The structure and properties of boron carbide ceramics modified by high-current pulsed electron-beam

    Energy Technology Data Exchange (ETDEWEB)

    Ivanov, Yuri, E-mail: yufi55@mail.ru [Institute of High-Current Electronics of the Siberian Branch of the Russian Academy of Sciences, 2/3 Akademicheskiy Ave. Tomsk, 634055 (Russian Federation); National Research Tomsk State University, 36 Lenina Str., Tomsk, 634050 (Russian Federation); National Research Tomsk Polytechnic University, 30 Lenina Str., Tomsk, 634050 (Russian Federation); Tolkachev, Oleg, E-mail: ole.ts@mail.ru; Petyukevich, Maria, E-mail: petukevich@tpu.ru; Polisadova, Valentina, E-mail: polis@tpu.ru [National Research Tomsk Polytechnic University, 30 Lenina Str., Tomsk, 634050 (Russian Federation); Teresov, Anton, E-mail: tad514@sibmail.com [Institute of High-Current Electronics of the Siberian Branch of the Russian Academy of Sciences, 2/3 Akademicheskiy Ave. Tomsk, 634055 (Russian Federation); National Research Tomsk State University, 36 Lenina Str., Tomsk, 634050 (Russian Federation); Ivanova, Olga, E-mail: ivaov@mail.ru; Ikonnikova, Irina, E-mail: irina-ikonnikova@yandex.ru [Tomsk State University of Architecture and Building, 2 Solyanaya Sq., Tomsk, 634003 (Russian Federation)

    2016-01-15

    The present work is devoted to numerical simulation of temperature fields and the analysis of structural and strength properties of the samples surface layer of boron carbide ceramics treated by the high-current pulsed electron-beam of the submillisecond duration. The samples made of sintered boron carbide ceramics are used in these investigations. The problem of calculating the temperature field is reduced to solving the thermal conductivity equation. The electron beam density ranges between 8…30 J/cm{sup 2}, while the pulse durations are 100…200 μs in numerical modelling. The results of modelling the temperature field allowed ascertaining the threshold parameters of the electron beam, such as energy density and pulse duration. The electron beam irradiation is accompanied by the structural modification of the surface layer of boron carbide ceramics either in the single-phase (liquid or solid) or two-phase (solid-liquid) states. The sample surface of boron carbide ceramics is treated under the two-phase state (solid-liquid) conditions of the structural modification. The surface layer is modified by the high-current pulsed electron-beam produced by SOLO installation at the Institute of High Current Electronics of the Siberian Branch of the Russian Academy of Sciences, Tomsk, Russia. The elemental composition and the defect structure of the modified surface layer are analyzed by the optical instrument, scanning electron and transmission electron microscopes. Mechanical properties of the modified layer are determined measuring its hardness and crack resistance. Research results show that the melting and subsequent rapid solidification of the surface layer lead to such phenomena as fragmentation due to a crack network, grain size reduction, formation of the sub-grained structure due to mechanical twinning, and increase of hardness and crack resistance.

  3. Measurement of neutral current coherent neutral pion production on carbon in a few-GeV neutrino beam

    CERN Document Server

    Kurimoto, Y; Brice, S J; Bugel, L; Catala-Perez, J; Cheng, G; Conrad, J M; Djurcic, Z; Dore, U; Finley, D A; Franke, A J; Giganti, C; Gomez-Cadenas, J J; Guzowski, P; Hanson, A; Hayato, Y; Hiraide, K; Jover-Manas, G; Karagiorgi, G; Katori, T; Kobayashi, Y K; Kobilarcik, T; Kubo, H; Louis, W C; Loverre, P F; Ludovici, L; Mahn, K B M; Mariani, C; Masuike, S; Matsuoka, K; McGary, V T; Metcalf, W; Mills, G B; Mitsuka, G; Miyachi, Y; Mizugashira, S; Moore, C D; Nakajima, Y; Nakaya, T; Napora, R; Nienaber, P; Orme, D; Otani, M; Russell, A D; Sanchez, F; Shaevitz, M H; Shibata, T -A; Sorel, M; Stefanski, R J; Takei, H; Tanaka, H -K; Tanaka, M; Tayloe, R; Taylor, I J; Tesarek, R J; Uchida, Y; Van de Water, R; Walding, J J; Wascko, M O; White, H B; Wilking, M J; Yokoyama, M; Zeller, G P; Zimmerman, E D

    2010-01-01

    The SciBooNE Collaboration reports a measurement of neutral current coherent neutral pion production on carbon by a muon neutrino beam with average energy 0.8 GeV. The separation of coherent from inclusive neutral pion production has been improved by detecting recoil protons from resonant neutral pion production. We measure the ratio of the neutral current coherent neutral pion production to total charged current cross sections to be (1.16 +/- 0.24) x 10-2. The ratio of charged current coherent pion to neutral current coherent pion production is calculated to be 0.14+0.30 -0.28, using our published charged current coherent pion measurement.

  4. MEK Inhibitors Reverse cAMP-Mediated Anxiety in Zebrafish

    DEFF Research Database (Denmark)

    Lundegaard, Pia R.; Anastasaki, Corina; Grant, Nicola J.

    2015-01-01

    Altered phosphodiesterase (PDE)-cyclic AMP (cAMP) activity is frequently associated with anxiety disorders, but current therapies act by reducing neuronal excitability rather than targeting PDE-cAMP-mediated signaling pathways. Here, we report the novel repositioning of anti-cancer MEK inhibitors...... as anxiolytics in a zebrafish model of anxiety-like behaviors. PDE inhibitors or activators of adenylate cyclase cause behaviors consistent with anxiety in larvae and adult zebrafish. Small-molecule screening identifies MEK inhibitors as potent suppressors of cAMP anxiety behaviors in both larvae and adult...... zebrafish, while causing no anxiolytic behavioral effects on their own. The mechanism underlying cAMP-induced anxiety is via crosstalk to activation of the RAS-MAPK signaling pathway. We propose that targeting crosstalk signaling pathways can be an effective strategy for mental health disorders, and advance...

  5. Proton Beam Therapy for Non-Small Cell Lung Cancer: Current Clinical Evidence and Future Directions

    Directory of Open Access Journals (Sweden)

    Abigail T. Berman

    2015-07-01

    Full Text Available Lung cancer is the leading cancer cause of death in the United States. Radiotherapy is an essential component of the definitive treatment of early-stage and locally-advanced lung cancer, and the palliative treatment of metastatic lung cancer. Proton beam therapy (PBT, through its characteristic Bragg peak, has the potential to decrease the toxicity of radiotherapy, and, subsequently improve the therapeutic ratio. Herein, we provide a primer on the physics of proton beam therapy for lung cancer, present the existing data in early-stage and locally-advanced non-small cell lung cancer (NSCLC, as well as in special situations such as re-irradiation and post-operative radiation therapy. We then present the technical challenges, such as anatomic changes and motion management, and future directions for PBT in lung cancer, including pencil beam scanning.

  6. System Overview and Current Status of the ESS Beam Position Monitors

    OpenAIRE

    Hassanzadegan, Hooman; Jansson, Andreas; Thomas, Cyrille; Lipka, Dirk; Werner, Matthias; Young, Andrew

    2014-01-01

    It is planned to install more than 140 button BPMs along the ESS linac. The BPMs will be used to measure the beam position and phase in all foreseen beam modes and to provide input to the Machine Interlock System. The phase measurement is mainly intended for cavity tuning and Time-Of-Flight energy measurements. A customized BPM detector based on the European XFEL button style has been designed for the cold linac through a collaboration with DESY. Large buttons with diameters up to 40 mm are f...

  7. Surface Nanocrystallization of 3Cr13 Stainless Steel Induced by High-Current Pulsed Electron Beam Irradiation

    OpenAIRE

    2013-01-01

    The nanocrystalline surface was produced on 3Cr13 martensite stainless steel surface using high-current pulsed electron beam (HCPEB) technique. The structures of the nanocrystallized surface were characterized by X-ray diffraction and electron microscopy. Two nanostructures consisting of fine austenite grains (50–150 nm) and very fine carbides precipitates are formed in melted surface layer after multiple bombardments via dissolution of carbides and crater eruption. It is demonstrated that th...

  8. Measurement of Inclusive Neutral Current Neutral Pion Production on Carbon in a Few-GeV Neutrino Beam

    CERN Document Server

    Kurimoto, Y

    2009-01-01

    The SciBooNE Collaboration reports inclusive neutral current neutral pion production by a muon neutrino beam on a polystyrene target (C8H8). We obtain (7.7 \\pm 0.5(stat.) \\pm 0.5 (sys.)) x 10^(-2) as the ratio of the neutral current neutral pion production to total charged current cross section; the mean energy of neutrinos producing detected neutral pions is 1.1 GeV. The result agrees with the Rein-Sehgal model implemented in our neutrino interaction simulation program with nuclear effects. The spectrum shape of the neutral pion momentum and angle agree with the model. We also measure the ratio of the neutral current coherent pion production to total charged current cross section to be (0.9 \\pm 0.5) x 10^(-2).

  9. A high current sinusoidal pulse generator for the diluter magnets of the LHC beam dump system

    CERN Document Server

    Vossenberg, Eugène B; Ducimetière, L; Schröder, G H

    2000-01-01

    CERN is constructing the Large Hadron Collider (LHC), a superconducting accelerator that will collide protons at a center of mass energy of 14 TeV. The two colliding beams will each store an energy of up to 540 MJ, which must be safely deposited within one beam revolution of 89 mu s on two external absorbers located about 700 m from the extraction points at the end of dedicated extraction tunnels. To avoid evaporation of the graphite absorber material by the very high energy density of the incident beams, the deposition area of the beams on the absorber front face will be increased. This is done by a pair of sinusoidally powered orthogonal magnet systems producing approximately an e-shape figure of about 35 mm diameter, with a minimum velocity of 10 mm/ mu s during the dumping process. The pulse generators of the horizontally and vertically deflecting diluter magnets are composed of capacitor banks, discharged by stacks of solid state closing switches. They are connected to the magnets by 28 m long low induct...

  10. Beam Envelope, Injection and Acceleration in a Compact, High Current, Strong Focused Recirculating Accelerator Scheme

    Science.gov (United States)

    1988-12-01

    fixed vertical (berding) magnetic field, the insensitivity to energy i tdh poses a problem for ban trqaing and injectin. It is shoam that a ber trapping...Institute for Acetor and Plasma Beam Technology University of New Mexico A~xxpierque, N 87131 1 Dr. C. L. Hanner De e of Physics Iowa State University

  11. Effect of high current electron beam in a 30 MeV radio frequency linac for neutron-time-of-flight applications

    Energy Technology Data Exchange (ETDEWEB)

    Nayak, B., E-mail: biswaranjan.nayak1@gmail.com; Acharya, S.; Rajawat, R. K. [Accelerator and Pulsed Power Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085 (India); DasGupta, K. [Accelerator and Pulsed Power Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085 (India); Beam Technology Development Group, BARC, Mumbai 400085 (India)

    2016-01-15

    A high power pulsed radio frequency electron linac is designed by BARC, India to accelerate 30 MeV, 10 A, 10 ns beam for neutron-time-of-flight applications. It will be used as a neutron generator and will produce ∼10{sup 12}–10{sup 13} n/s. It is essential to reduce the beam instability caused by space charge effect and the beam cavity interaction. In this paper, the wakefield losses in the accelerating section due to bunch of RMS (Root mean square) length 2 mm (at the gun exit) is analysed. Loss and kick factors are numerically calculated using CST wakefield solver. Both the longitudinal and transverse wake potentials are incorporated in beam dynamics code ELEGANT to find the transverse emittance growth of the beam propagating through the linac. Beam loading effect is examined by means of numerical computation carried out in ASTRA code. Beam break up start current has been estimated at the end of the linac which arises due to deflecting modes excited by the high current beam. At the end, transverse beam dynamics of such high current beam has been analysed.

  12. Development of 2D particle-in-cell code to simulate high current, low energy beam in a beam transport system

    Indian Academy of Sciences (India)

    S C L Srivastava; S V L S Rao; P Singh

    2007-10-01

    A code for 2D space-charge dominated beam dynamics study in beam transport lines is developed. The code is used for particle-in-cell (PIC) simulation of -uniform beam in a channel containing solenoids and drift space. It can also simulate a transport line where quadrupoles are used for focusing the beam. Numerical techniques as well as the results of beam dynamics studies are presented in the paper.

  13. The first Pico-Ficino Controversy

    DEFF Research Database (Denmark)

    Aasdalen, Unn Irene

    2011-01-01

    In the first controversy between Marsilio Ficino (1433-1499) and Giovanni Pico della Mirandola (1463-1494), the Florentine Duecento poet Guido Cavalcanti is central to the argument. The dispute between Ficino and Pico over Cavalcanti’s canzone Donna me prega is therefore in this article used...... in an attempt to throw light upon their further disagreement about the Platonic philosophy of love. The first Pico-Ficino controversy is in part played out over Florentine poetry, but does not have poetry as its prime concern. In essence, the miniature dispute about the Donna me prega encapsulates a grand...... mainly through the seventh book of his Symposium commentary, and Pico’s counter-position from his detailed commentary on a canzone by Girolamo Benivieni’s, the Amor dalle cui, in his Commento....

  14. Current status of ATLAS and proposed expansion to an exotic beam facility

    Science.gov (United States)

    Zinkann, G. P.; Billquist, P.; Bogaty, J.; Clifft, B.; Munson, F.; Nakagawa, K.; Nolen, J.; Pardo, R.; Shepard, K. W.; Specht, J.; Sutherland, A.; Tieman, B.; Tilbrook, I.

    1996-02-01

    The Argonne Tandem Linear Accelerator System (ATLAS) has been operating on a 24 hour, seven days a week schedule since the beginning of Fiscal Year 1994. Twenty-six different ion species ran during this period in 71 separate experiments. During the past year, there have been many projects undertaken to improve operation efficiency and upgrade various accelerator systems. There is also a new ECR ion source construction project underway. This paper covers, linac operation and new tuning techniques, the second generation ECR source construction project, the refrigerator system upgrade, an upgrade to the control system. Also described is a future expansion of ATLAS as an Exotic Beam Facility. (ATLAS is a world class heavy ion accelerator with an estimated value of approximately $80 million.) A concept that would utilize ATLAS as the foundation for a facility to generate and accelerate radioactive beams is briefly discussed.

  15. Warmer amps for the LHC

    CERN Multimedia

    Anaïs Schaeffer

    2012-01-01

    CERN is working together with an Italian company to develop superconducting cables that can function at temperatures of up to 25 K (-248°C). This will make it possible to move LHC magnet power supplies out of the tunnel, protecting them from exposure to the showers of very high-energy particles produced by the accelerator.   Figure 1: devices of this type, which measure approximately 10 metres in length, are inserted between the accelerating magnets at different points along the LHC. When it comes to consuming electricity, the magnets that steer particles through large accelerators can be characterised with just one word: greedy. For the LHC, the total current can reach 1.5 million amps. At the present time, this current is brought in via copper cables of up to 10 cm in diameter. In the tunnel, these cables connect the current leads - which provide the transition between the ambient-temperature cables and the magnets in their bath of superfluid helium - to the power supply. In the a...

  16. High-resolution electron-beam-induced-current study of the defect structure in GaN epilayers

    CERN Document Server

    Shmidt, N M; Usikov, A S; Yakimov, E B; Zavarin, E E

    2002-01-01

    Electron-beam-induced-current (EBIC) investigations of GaN structures grown by metal-organic chemical vapour deposition on (0001) sapphire substrates have been carried out. It is shown that the widths of the EBIC profiles for individual extended defects can be as small as about 100 nm. This width is observed to decrease with decreasing diffusion length and/or with increasing electron beam energy. The high spatial resolution is explained by the small diffusion length in the samples under study. The diffusion length is small even in structures with dislocation densities of about 10 sup 8 cm sup - sup 3 and carrier mobilities of about 600 cm sup 2 V sup - sup 1 s sup - sup 1 at 300 K and 1800 cm sup 2 V sup - sup 1 s sup - sup 1 at 125 K.

  17. Internal gastargets in AmPS

    Science.gov (United States)

    Kaan, A. P.; Postma, O.; van den Brand, J. F. J.; van Leeuwen, E.; Doets, M.; Kraan, M.

    1997-05-01

    Internal gas targets in AmPS A.P. Kaan, O. Postma, J.F.J. van den Brand, E. van Leeuwen, M. Doets, M. Kra= an National Institute for Nuclear Physics and High Energy Physics; Kruislaan 409; 1098 SJ Amsterdam; Holland In the Amsterdam Puls Stretcher/storage ring AmPS(1 GeV electrons), we designed a set-up in order to accommodate a gas target with a density of 1016 mol/cm2. The storage cell needed for this purpose is a aluminium tube with a length of 40 cm, a diameter of 15 mm and a wall thickness of 25 =B5m. Three sets of conductance limiters on both sides of the target, combined with dry turbopumps are designed to be used as differential pumping stations. These limiters cause discontinuities in the beam path and must therefor be retractable and radio frequency compatible in both positions. Low =B5 materials must be used because of the depolarisation effects of changing magnetic fields. The calculations show that the flow resistance's are sufficient to reduce the load of the getter pumps to a level with which the lifetime of the pump elements remain acceptable. The design of the mechanics and the vacuum system will be explained. Recent results from the measurements after installation in combination with the influence on the lifetime on the beam will be presented

  18. Design of a high-current low-energy beam transport line for an intense D-T/D-D neutron generator

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Xiaolong, E-mail: luxl@lzu.edu.cn [School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000 (China); Engineering Research Center for Neutron Application, Ministry of Education, Lanzhou University, Lanzhou 730000 (China); Wang, Junrun [School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000 (China); Engineering Research Center for Neutron Application, Ministry of Education, Lanzhou University, Lanzhou 730000 (China); Zhang, Yu; Li, Jianyi; Xia, Li; Zhang, Jie; Ding, Yanyan; Jiang, Bing; Huang, Zhiwu; Ma, Zhanwen; Wei, Zheng [School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000 (China); Qian, Xiangping; Xu, Dapeng; Lan, Changlin [School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000 (China); Engineering Research Center for Neutron Application, Ministry of Education, Lanzhou University, Lanzhou 730000 (China); Yao, Zeen, E-mail: zeyao@lzu.edu.cn [School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000 (China); Engineering Research Center for Neutron Application, Ministry of Education, Lanzhou University, Lanzhou 730000 (China)

    2016-03-01

    An intense D-T/D-D neutron generator is currently being developed at the Lanzhou University. The Cockcroft–Walton accelerator, as a part of the neutron generator, will be used to accelerate and transport the high-current low-energy beam from the duoplasmatron ion source to the rotating target. The design of a high-current low-energy beam transport (LEBT) line and the dynamics simulations of the mixed beam were carried out using the TRACK code. The results illustrate that the designed beam line facilitates smooth transportation of a deuteron beam of 40 mA, and the number of undesired ions can be reduced effectively using two apertures.

  19. Overview of Alternative Bunching and Current-shaping Techniques for Low-Energy Electron Beams

    Energy Technology Data Exchange (ETDEWEB)

    Piot, Philippe [Northern Illinois U.

    2015-12-01

    Techniques to bunch or shape an electron beam at low energies (E <15 MeV) have important implications toward the realization of table-top radiation sources [1] or to the design of compact multi-user free-electron lasers[2]. This paper provides an overview of alternative methods recently developed including techniques such as wakefield-based bunching, space-charge-driven microbunching via wave-breaking [3], ab-initio shaping of the electron-emission process [4], and phase space exchangers. Practical applications of some of these methods to foreseen free-electron-laser configurations are also briefly discussed [5].

  20. Pio Pico: Breaking the Culture of Silence.

    Science.gov (United States)

    Aguirre, JoAnn Kawamura

    This qualitative study explored the presence of community voice in a newly structured inner-city elementary school in Santa Ana (California). Nearly every family at Pio Pico Elementary School lives below the poverty level, and Spanish is the primary language of 90% of the residents, with most families being of Mexican or Central American origin.…

  1. Formation Mechanism of Micropores on the Surface of Pure Aluminum Induced by High-Current Pulsed Electron Beam Irradiation

    Institute of Scientific and Technical Information of China (English)

    ZOU Yang; CAI Jie; WAN Ming-Zhen; LV Peng; GUAN Qing-Feng

    2011-01-01

    The mechanism of micropores formed on the surface of polycrystalline pure aluminum under high-current pulsed electron beam (HCPEB) irradiation is explained. It is discovered that dispersed micropores with sizes of 0.1-1μm on the irradiated surface of pure aluminum can be successfully fabricated after HCPEB irradiation. The dominant formation mechanism of the surface micropores should be attributed to the formation of supersaturation vacancies within the near surface during the HCPEB irradiation and the migration of vacancies along gra,in boundaries and/or dislocations towards the irradiated surface. It is expected that the HCPEB technique will become a new method for the rapid synthesis of surface porous materials.%The mechanism of micropores formed on the surface of polycrystalline pure aluminum under high-current pulsed electron beam (HCPEB) irradiation is explained.It is discovered that dispersed micropores with sizes of 0.1-1μm on the irradiated surface of pure aluminum can be successfully fabricated after HCPEB irradiation.The dominant formation mechanism of the surface micropores should be attributed to the formation of supersaturation vacancies within the near surface during the HCPEB irradiation and the migration of vacancies along grain boundaries and/or dislocations towards the irradiated surface.It is expected that the HCPEB technique will become a new method for the rapid synthesis of surface porous materials.High-current pulsed electron beams (HCPEBs)have attracted much attention in the field of material surface modification.[1-7] During the transient bombardment process a high energy (108-109 W·cm-2) is deposited only in a very thin layer (less than tens of micrometers) within a very short time (a few microseconds) and thereby causes ultrafast heating and cooling on the irradiated surface of materials.The dynamic stress fields induced in these processes can induce intense deformation on the material surface.

  2. High speed, intermediate resolution, large area laser beam induced current imaging and laser scribing system for photovoltaic devices and modules.

    Science.gov (United States)

    Phillips, Adam B; Song, Zhaoning; DeWitt, Jonathan L; Stone, Jon M; Krantz, Patrick W; Royston, John M; Zeller, Ryan M; Mapes, Meghan R; Roland, Paul J; Dorogi, Mark D; Zafar, Syed; Faykosh, Gary T; Ellingson, Randy J; Heben, Michael J

    2016-09-01

    We have developed a laser beam induced current imaging tool for photovoltaic devices and modules that utilizes diode pumped Q-switched lasers. Power densities on the order of one sun (100 mW/cm(2)) can be produced in a ∼40 μm spot size by operating the lasers at low diode current and high repetition rate. Using galvanostatically controlled mirrors in an overhead configuration and high speed data acquisition, large areas can be scanned in short times. As the beam is rastered, focus is maintained on a flat plane with an electronically controlled lens that is positioned in a coordinated fashion with the movements of the mirrors. The system can also be used in a scribing mode by increasing the diode current and decreasing the repetition rate. In either mode, the instrument can accommodate samples ranging in size from laboratory scale (few cm(2)) to full modules (1 m(2)). Customized LabVIEW programs were developed to control the components and acquire, display, and manipulate the data in imaging mode.

  3. High speed, intermediate resolution, large area laser beam induced current imaging and laser scribing system for photovoltaic devices and modules

    Science.gov (United States)

    Phillips, Adam B.; Song, Zhaoning; DeWitt, Jonathan L.; Stone, Jon M.; Krantz, Patrick W.; Royston, John M.; Zeller, Ryan M.; Mapes, Meghan R.; Roland, Paul J.; Dorogi, Mark D.; Zafar, Syed; Faykosh, Gary T.; Ellingson, Randy J.; Heben, Michael J.

    2016-09-01

    We have developed a laser beam induced current imaging tool for photovoltaic devices and modules that utilizes diode pumped Q-switched lasers. Power densities on the order of one sun (100 mW/cm2) can be produced in a ˜40 μm spot size by operating the lasers at low diode current and high repetition rate. Using galvanostatically controlled mirrors in an overhead configuration and high speed data acquisition, large areas can be scanned in short times. As the beam is rastered, focus is maintained on a flat plane with an electronically controlled lens that is positioned in a coordinated fashion with the movements of the mirrors. The system can also be used in a scribing mode by increasing the diode current and decreasing the repetition rate. In either mode, the instrument can accommodate samples ranging in size from laboratory scale (few cm2) to full modules (1 m2). Customized LabVIEW programs were developed to control the components and acquire, display, and manipulate the data in imaging mode.

  4. On-line measurements of proton beam current from a PET cyclotron using a thin aluminum foil

    Science.gov (United States)

    Ghithan, S.; do Carmo, S. J. C.; Ferreira Marques, R.; Fraga, F. A. F.; Simões, H.; Alves, F.; Crespo, P.

    2013-07-01

    The number of cyclotrons capable of accelerating protons to about 20 MeV is increasing throughout the world. Originally aiming at the production of positron emission tomography (PET) radionuclides, some of these facilities are equipped with several beam lines suitable for scientific research. Radiobiology, radiophysiology, and other dosimetric studies can be performed using these beam lines. In this work, we measured the Bragg peak of the protons from a PET cyclotron using a stacked target consisting of several aluminum foils interleaved with polyethylene sheets, readout by in-house made transimpedance electronics. The measured Bragg peak is consistent with simulations performed using the SRIM/TRIM simulation toolkit. Furthermore, we report on experimental results aiming at measuring proton beam currents down to 10 pA using a thin aluminum foil (20-μm-thick). The aluminum was chosen for this task because it is radiation hard, it has low density and low radiation activity, and finally because it is easily available at negligible cost. This method allows for calculating the dose delivered to a target during an irradiation with high efficiency, and with minimal proton energy loss and scattering.

  5. High-current long-duration uniform electron beam generation in a diode with multicapillary carbon-epoxy cathode

    Energy Technology Data Exchange (ETDEWEB)

    Queller, T.; Gleizer, J. Z.; Krasik, Ya. E. [Physics Department, Technion, Haifa 32000 (Israel)

    2013-09-28

    The results of reproducibly generating an electron beam with a current density of up to 5 kA/cm{sup 2}, without the cathode-anode gap being shorted by the plasma formed inside the cathode carbon-epoxy capillaries, in a ∼350 kV, ∼600 ns diode, with and without an external guiding magnetic field, are presented. The cathode sustained hundreds of pulses without degradation of its emission properties. Time- and space-resolved emissions of the plasma and spectroscopy analyses were used to determine the cathode plasma's density, temperature, and expansion velocity.

  6. High-current long-duration uniform electron beam generation in a diode with multicapillary carbon-epoxy cathode

    Science.gov (United States)

    Queller, T.; Gleizer, J. Z.; Krasik, Ya. E.

    2013-09-01

    The results of reproducibly generating an electron beam with a current density of up to 5 kA/cm2, without the cathode-anode gap being shorted by the plasma formed inside the cathode carbon-epoxy capillaries, in a ˜350 kV, ˜600 ns diode, with and without an external guiding magnetic field, are presented. The cathode sustained hundreds of pulses without degradation of its emission properties. Time- and space-resolved emissions of the plasma and spectroscopy analyses were used to determine the cathode plasma's density, temperature, and expansion velocity.

  7. Current-driven ion-acoustic and potential-relaxation instabilities excited in plasma plume during electron beam welding

    Science.gov (United States)

    Trushnikov, D. N.; Mladenov, G. M.; Belenkiy, V. Ya.; Koleva, E. G.; Varushkin, S. V.

    2014-04-01

    Many papers have sought correlations between the parameters of secondary particles generated above the beam/work piece interaction zone, dynamics of processes in the keyhole, and technological processes. Low- and high-frequency oscillations of the current, collected by plasma have been observed above the welding zone during electron beam welding. Low-frequency oscillations of secondary signals are related to capillary instabilities of the keyhole, however; the physical mechanisms responsible for the high-frequency oscillations (>10 kHz) of the collected current are not fully understood. This paper shows that peak frequencies in the spectra of the collected high-frequency signal are dependent on the reciprocal distance between the welding zone and collector electrode. From the relationship between current harmonics frequency and distance of the collector/welding zone, it can be estimated that the draft velocity of electrons or phase velocity of excited waves is about 1600 m/s. The dispersion relation with the properties of ion-acoustic waves is related to electron temperature 10 000 K, ion temperature 2 400 K and plasma density 1016 m-3, which is analogues to the parameters of potential-relaxation instabilities, observed in similar conditions. The estimated critical density of the transported current for creating the anomalous resistance state of plasma is of the order of 3 A.m-2, i.e. 8 mA for a 3-10 cm2 collector electrode. Thus, it is assumed that the observed high-frequency oscillations of the current collected by the positive collector electrode are caused by relaxation processes in the plasma plume above the welding zone, and not a direct demonstration of oscillations in the keyhole.

  8. Self-focusing of a high current density ion beam extracted with concave electrodes in a low energy region around 150 eV

    Energy Technology Data Exchange (ETDEWEB)

    Hirano, Y., E-mail: y.hirano@aist.go.jp [Innovative Plasma Technologies Group, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki (Japan); Laboratory of Physics, College of Science and Technologies, Nihon University, Tokyo (Japan); Kiyama, S.; Koguchi, H. [Innovative Plasma Technologies Group, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki (Japan); Sakakita, H. [Innovative Plasma Technologies Group, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki (Japan); Department of Engineering Mechanics and Energy, University of Tsukuba, Ibaraki (Japan)

    2014-02-15

    Spontaneous self-focusing of ion beam with high current density (J{sub c} ∼ 2 mA/cm{sup 2}, I{sub b} ∼ 65 mA) in low energy region (∼150 eV) is observed in a hydrogen ion beam extracted from an ordinary bucket type ion source with three electrodes having concave shape (acceleration, deceleration, and grounded electrodes). The focusing appears abruptly in the beam energy region over ∼135–150 eV, and the J{sub c} jumps up from 0.7 to 2 mA/cm{sup 2}. Simultaneously a strong electron flow also appears in the beam region. The electron flow has almost the same current density. Probably these electrons compensate the ion space charge and suppress the beam divergence.

  9. Low-Power Reflective Optical Communication System for Pico- and Nano-Satellites

    Science.gov (United States)

    Sinn, A.; Riel, T.; Deisl, F.; Saathof, R.; Schitter, G.

    2016-09-01

    Pico- and nano-satellites (PNS) are promising options for cost-effective and rapid deployable satellite systems. Due to their small size, the available power and therefore the transmittable data volume is limited. This paper proposes optical communication by means of reflected laser light using a modulating retro-reflector (MRR) for energy efficient optical communication with PNS. No laser source or beam steering assembly is necessary at the satellite, thus allowing a weight and energy efficient communication interface. Existing ground stations (GS) as used for satellite laser ranging (SLR) provide all equipment required for this system. By providing a link budget for communication to PNS in LEOs feasibility is investigated. It is shown that an affordable GS based on small telescopes with diameters below 0.3m in combination with commercial mounts enables the targeted application. A detailed analysis of LCD based MRRs is shown, denoting cost-efficient modulators for reflective optical communication. A data-rate of 2.5kbps at an input power of less than 80 mW is shown in a laboratory setup. Using a high performance sampling circuit and a laser power of only 1mW, a bit error ratio (BER) of below 10e-3 is achieved, successfully demonstrating reflective optical communication as an alternative to current RF based systems.

  10. Sleutelmag en amp

    Directory of Open Access Journals (Sweden)

    P. J. Rossouw

    1985-06-01

    Full Text Available As die Heidelbergse Kategismus (Sondag 31 handel oor die sleutels van die Koninkryk, dan word die betrokkenheid van die ampte slegs per implikasie veronderstel. Meer eksplisiet word die amp en sleutelmag in die Nederlandse Geloofsbelydenis gekoppel; “ons glo dat hierdie ware kerk ooreenkomstig die geestelike bestuurswyse wat ons Here ons in sy Woord geleer het, geregeer moet word... hulle (moet sorg dra dat die ware godsdiens onderhou (word, die ware leer orals versprei, die oortreders op geestelike wyse vermaan en in toom gehou (word... (N.G.B. art. 30 en: “Ons glo verder dat die regeerders van die kerk, al is dit nuttig en goed om onder mekaar ’n bepaalde orde tot instandhouding van die liggaam van die kerk in te stel en te handhaaf, tog noukeurig moet oppas om nie af te wyk van wat Christus, ons enigste Meester, vir ons ingestel het nie... Ons aanvaar derhalwe slegs wat kan dien om eendrag en eenheid te bewaar en te bevorder, en om alles in gehoorsaamheid van God te onderhou. Daarvoor is nodig die ban en alles wat daarmee saamhang, toegepas ooreenkomstig die Woord van God” (N.G.B. art. 32.

  11. High-current negative hydrogen ion beam production in a cesium-injected multicusp source

    Energy Technology Data Exchange (ETDEWEB)

    Takeiri, Y.; Tsumori, K.; Kaneko, O. [National Inst. for Fusion Science, Nagoya (Japan)] [and others

    1997-12-31

    A high-current negative hydrogen ion source has been developed, where 16.2 A of the H{sup -} current was obtained with a current density of 31 mA/cm{sup 2}. The ion source is a multicusp source with a magnetic filter for negative ion production, and cesium vapor is injected into the arc chamber, leading to enhancement of the negative ion yields. The cesium-injection effects are discussed, based on the experimental observations. Although the surface production of the negative ions on the cesium-covered plasma grid is thought to be a dominant mechanism of the H{sup -} current enhancement, the cesium effects in the plasma volume, such as the cesium ionization and the electron cooling, are observed, and could contribute to the improved operation of the negative ion source. (author)

  12. PROSPECTS OF HIGH-CURRENT ELECTRON BEAMS APPLICATION TO RADIATION POLYETHYLENE CROSS-LINKING

    Directory of Open Access Journals (Sweden)

    A.G. Gurin

    2013-09-01

    Full Text Available A possibility of applying a pulse-periodic high-current induction electron accelerators to radiation polyethylene cross-linking is considered in the article. A comparative analysis with other devices used for irradiation is made.

  13. Development of a low-energy and high-current pulsed neutral beam injector with a washer-gun plasma source for high-beta plasma experiments.

    Science.gov (United States)

    Ii, Toru; Gi, Keii; Umezawa, Toshiyuki; Asai, Tomohiko; Inomoto, Michiaki; Ono, Yasushi

    2012-08-01

    We have developed a novel and economical neutral-beam injection system by employing a washer-gun plasma source. It provides a low-cost and maintenance-free ion beam, thus eliminating the need for the filaments and water-cooling systems employed conventionally. In our primary experiments, the washer gun produced a source plasma with an electron temperature of approximately 5 eV and an electron density of 5 × 10(17) m(-3), i.e., conditions suitable for ion-beam extraction. The dependence of the extracted beam current on the acceleration voltage is consistent with space-charge current limitation, because the observed current density is almost proportional to the 3/2 power of the acceleration voltage below approximately 8 kV. By optimizing plasma formation, we successfully achieved beam extraction of up to 40 A at 15 kV and a pulse length in excess of 0.25 ms. Its low-voltage and high-current pulsed-beam properties enable us to apply this high-power neutral beam injection into a high-beta compact torus plasma characterized by a low magnetic field.

  14. Multiple Facets of cAMP Signalling and Physiological Impact: cAMP Compartmentalization in the Lung

    Directory of Open Access Journals (Sweden)

    Martina Schmidt

    2012-11-01

    Full Text Available Therapies involving elevation of the endogenous suppressor cyclic AMP (cAMP are currently used in the treatment of several chronic inflammatory disorders, including chronic obstructive pulmonary disease (COPD. Characteristics of COPD are airway obstruction, airway inflammation and airway remodelling, processes encompassed by increased airway smooth muscle mass, epithelial changes, goblet cell and submucosal gland hyperplasia. In addition to inflammatory cells, airway smooth muscle cells and (myofibroblasts, epithelial cells underpin a variety of key responses in the airways such as inflammatory cytokine release, airway remodelling, mucus hypersecretion and airway barrier function. Cigarette smoke, being next to environmental pollution the main cause of COPD, is believed to cause epithelial hyperpermeability by disrupting the barrier function. Here we will focus on the most recent progress on compartmentalized signalling by cAMP. In addition to G protein-coupled receptors, adenylyl cyclases, cAMP-specific phospho-diesterases (PDEs maintain compartmentalized cAMP signalling. Intriguingly, spatially discrete cAMP-sensing signalling complexes seem also to involve distinct members of the A-kinase anchoring (AKAP superfamily and IQ motif containing GTPase activating protein (IQGAPs. In this review, we will highlight the interaction between cAMP and the epithelial barrier to retain proper lung function and to alleviate COPD symptoms and focus on the possible molecular mechanisms involved in this process. Future studies should include the development of cAMP-sensing multiprotein complex specific disruptors and/or stabilizers to orchestrate cellular functions. Compartmentalized cAMP signalling regulates important cellular processes in the lung and may serve as a therapeutic target.

  15. Strengthening effect of nano-scaled precipitates in Ta alloying layer induced by high current pulsed electron beam

    Energy Technology Data Exchange (ETDEWEB)

    Tang, Guangze; Luo, Dian; Fan, Guohua [School of Material Science & Engineering, Harbin Institute of Technology, Harbin 150001 (China); Ma, Xinxin, E-mail: maxin@hit.edu.cn [State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001 (China); Wang, Liqin [School of Mechatronics Engineering, Harbin Institute of Technology, Harbin 150001 (China)

    2017-05-01

    Highlights: • Ta alloying layer are fabricated by magnetron sputtering and high current pulsed electron beam. • Nano-scaled TaC precipitates forms within the δ-Fe grain after tempering treatment. • The mean diameter of TaC particles is about 5–8 nm. • The hardness of alloying layer increased by over 50% after formation of nano-scaled TaC particle. - Abstract: In this study, the combination of magnetron sputtering and high current pulsed electron beam are used for surface alloying treatment of Ta film on high speed steel. And the Ta alloying layer is about 6 μm. After tempering treatment, TaC phase forms in Ta alloying layer when the treated temperature is over 823 K. Through the TEM and HRTEM observation, a large amount of nano-scaled precipitates (mean diameter 5–8 nm) form within the δ-Fe grain in Ta alloying layer after tempering treatment and these nano-scaled precipitates are confirmed as TaC particles, which contribute to the strengthening effect of the surface alloying layer. The hardness of tempered alloying layer can reach to 18.1 GPa when the treated temperature is 823 K which increase by 50% comparing with the untreated steel sample before surface alloying treatment.

  16. Expression profiles of antimicrobial peptides (AMPs) and their regulation by Relish

    Science.gov (United States)

    Wang, Dongdong; Li, Fuhua; Li, Shihao; Wen, Rong; Xiang, Jianhai

    2012-07-01

    Antimicrobial peptides (AMPs), as key immune effectors, play important roles in the innate immune system of invertebrates. Different types of AMPs, including Penaeidin, Crustin, ALF (antilipopolysaccharide factor) have been identified in different penaeid shrimp; however, systematic analyses on the function of different AMPs in shrimp responsive to different types of bacteria are very limited. In this study, we analyzed the expression profiles of AMPs in the Chinese shrimps, Fenneropenaeus chinensis, simultaneously by real-time RT-PCR (reverse transcription-polymerase chain reaction) when shrimp were challenged with Micrococcus lysodeikticus (Gram-positive, G+) or Vibrio anguillarium (Gram-negative, G-). Different AMPs showed different expression profiles when shrimp were injected with one type of bacterium, and one AMP also showed different expression profiles when shrimp were challenged with different bacteria. Furthermore, the expression of these AMPs showed temporal expression profiles, suggesting that different AMPs function coordinately in bacteria-infected shrimp. An RNA interference approach was used to study the function of the Relish transcription factor in regulating the transcription of different AMPs. The current study showed that Relish could regulate the transcription of different AMPs in shrimp. Differential expression profiles of AMPs in shrimp injected with different types of bacteria indicated that a complicated antimicrobial response network existed in shrimp. These data contribute to our understanding of immunity in shrimp and may provide a strategy for the control of disease in shrimp.

  17. Assisted Medical Procedures (AMP) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Documentation and Development: The AMP was initially being developed as part the Advanced Integrated Clinical System (AICS)-Guided Medical Procedure System for the...

  18. Non-inductive current built-up by local electron cyclotron heating and current drive with a 28 GHz focused beam on QUEST

    Science.gov (United States)

    Onchi, Takumi; Idei, Hiroshi; Hasegawa, Makoto; Ohwada, Hiroaki; Zushi, Hideki; Hanada, Kazuaki; Kariya, Tsuyoshi; Mishra, Kishore; Shikama, Taichi; Quest Team

    2016-10-01

    The plasma current can be driven solely by injecting electron cyclotron waves (ECWs) in spherical tokamak (ST) configuration. A system of 28 GHz gyrotron (maximum power: 270 kW) is renewed and reinstalled on QUEST. A focused ECW beam, whose diameter is about 5 cm at the second harmonic resonance, is injected for local ECW heating and current drive. The local power density at resonance exceeds 75 MW/m2 at an injection power of 150 kW. The incident ECW polarization can be adjusted employing the phase shifter consisting of two corrugated plates. During 1.25 second pulse of ECH, plasma current is built up to Ip = 70 kA fully non-inductively with a core electron density of ne > 1018 m-3. The closed flux in such ST plasma is determined at the inboard limiter on the center stack. Energetic electrons are also responsible for the pressure and equilibrium. This work is supported by JSPS KAKENHI (15H04231, 15K17800), NIFS Collaboration Research program (NIFS13KUTR085, NIFS11KUTR069, NIFS16KUTR114).

  19. Characterisation of the incident beam and current diffraction capabilities on the VESUVIO spectrometer

    Science.gov (United States)

    Romanelli, G.; Krzystyniak, M.; Senesi, R.; Raspino, D.; Boxall, J.; Pooley, D.; Moorby, S.; Schooneveld, E.; Rhodes, N. J.; Andreani, C.; Fernandez-Alonso, F.

    2017-09-01

    The VESUVIO spectrometer at the ISIS pulsed neutron and muon source is a unique instrument amongst those available at neutron facilities. This is the only inverted-geometry neutron spectrometer accessing values of energy and wavevector transfer above tens of eV and {\\mathringA}-1 , respectively, and where deep inelastic neutron scattering experiments are routinely performed. As such, the procedure at the base of the technique has been previously described in an article published by this journal (Mayers and Reiter 2012 Meas. Sci. Technol. 23 045902). The instrument has recently witnessed an upsurge of interest due to a new trend to accommodate, within a single experiment, neutron diffraction and transmission measurements in addition to deep inelastic neutron scattering. This work presents a broader description of the instrument following these recent developments. In particular, we assess the absolute intensity and two-dimensional profile of the incident neutron beam and the capabilities of the backscattering diffraction banks. All results are discussed in the light of recent changes to the moderator viewed by the instrument. We find that VESUVIO has to be considered a high-resolution diffractometer as much as other diffractometers at ISIS, with a resolution as high as 2× 10-3 in backscattering. Also, we describe the extension of the wavelength range of the instrument to include lower neutron energies for diffraction measurements, an upgrade that could be readily applied to other neutron instruments as well.

  20. Development of an all-permanent-magnet microwave ion source equipped with multicusp magnetic fields for high current proton beam production.

    Science.gov (United States)

    Tanaka, M; Hara, S; Seki, T; Iga, T

    2008-02-01

    An all-permanent-magnet (APM) microwave hydrogen ion source was developed to reduce the size and to simplify structure of a conventional solenoid coil microwave ion source developed for reliability improvement of high current proton linac application systems. The difficulty in developing the APM source was sensitive dependence of the source performance on axial magnetic field in the microwave discharge chamber. It was difficult to produce high current proton beam stably without precise tuning of the magnetic field using solenoid coils. We lowered the sensitivity using multicusp magnetic fields for plasma confinement at the discharge chamber sidewall of the source. This enabled stable high current proton beam production with the APM microwave ion source with no tuning coil. The water cooling and the power supply for the coils are not necessary for the APM source, which leads to better reliability and system simplification. The outer diameter of the APM source was around 300 mm, which was 20% lower than the coil source. The APM source produced a maximum hydrogen ion beam current of 65 mA (high current density of 330 mA/cm(2), proton ratio of 87%, and beam energy of 30 keV) with a 5 mm diameter extraction aperture, pulse width of 400 micros, and 20 Hz repetition rate at 1.3 kW microwave power. This performance is almost the same as the best performances of the conventional coil sources. The extracted ion beams were focused with electrostatic five-grid lens to match beam to acceptance of radio-frequency quadrupole linacs. The maximum focused beam current through the orifice (5 mm radius) and the lens was 36 mA and the 90% focused beam half-width was 1-2 mm.

  1. Development of an all-permanent-magnet microwave ion source equipped with multicusp magnetic fields for high current proton beam productiona)

    Science.gov (United States)

    Tanaka, M.; Hara, S.; Seki, T.; Iga, T.

    2008-02-01

    An all-permanent-magnet (APM) microwave hydrogen ion source was developed to reduce the size and to simplify structure of a conventional solenoid coil microwave ion source developed for reliability improvement of high current proton linac application systems. The difficulty in developing the APM source was sensitive dependence of the source performance on axial magnetic field in the microwave discharge chamber. It was difficult to produce high current proton beam stably without precise tuning of the magnetic field using solenoid coils. We lowered the sensitivity using multicusp magnetic fields for plasma confinement at the discharge chamber sidewall of the source. This enabled stable high current proton beam production with the APM microwave ion source with no tuning coil. The water cooling and the power supply for the coils are not necessary for the APM source, which leads to better reliability and system simplification. The outer diameter of the APM source was around 300mm, which was 20% lower than the coil source. The APM source produced a maximum hydrogen ion beam current of 65mA (high current density of 330mA/cm2, proton ratio of 87%, and beam energy of 30keV) with a 5mm diameter extraction aperture, pulse width of 400μs, and 20Hz repetition rate at 1.3kW microwave power. This performance is almost the same as the best performances of the conventional coil sources. The extracted ion beams were focused with electrostatic five-grid lens to match beam to acceptance of radio-frequency quadrupole linacs. The maximum focused beam current through the orifice (5mm radius) and the lens was 36mA and the 90% focused beam half-width was 1-2mm.

  2. Source brightness and useful beam current of carbon nanotubes and other very small emitters

    NARCIS (Netherlands)

    Kruit, P.; Bezuijen, M.; Barth, J.E.

    2006-01-01

    The potential application of carbon nanotubes as electron sources in electron microscopes is analyzed. The resolution and probe current that can be obtained from a carbon nanotube emitter in a low-voltage scanning electron microscope are calculated and compared to the state of the art using Schottky

  3. Dark matter search project PICO-LON

    Science.gov (United States)

    Fushimi, K.; Ejiri, H.; Hazama, R.; Ikeda, H.; Imagawa, K.; Inoue, K.; Kanzaki, G.; Kozlov, A.; Orito, R.; Shima, T.; Takemoto, Y.; Teraoka, Y.; Umehara, S.; Yasuda, K.; Yoshida, S.; PICO-LON Collaboration

    2016-05-01

    The PICO-LON project aims at search for cold dark matter by means of highly radio-pure and large volume NaI(Tl) scintillator. The NaI powder was purified by chemical processing to remove lead isotopes and selecting a high purity graphite crucible. The concentrations of radioactive impurities of 226Ra and 228Th were effectively reduced to 58 ± 4 µBq/kg and 1.5 ± 1.9 µBq/kg, respectively. It should be remarked that the concentration of 210Pb, which is crucial for the sensitivity to dark matter, was reduced to 24 ± 2 µBq/kg. The total background rate at 10 keVee was as low as 8 keV-1kg-1day-1, which was sufficiently low to search for dark matter. Further purification of NaI(Tl) ingot and future prospect of PICO-LON project is discussed.

  4. Dark matter search project PICO-LON

    CERN Document Server

    Fushimi, K; Hazama, R; Ikeda, H; Imagawa, K; Inoue, K; Kanzaki, G; Kozlov, A; Orito, R; Shima, T; Takemoto, Y; Teraoka, Y; Umehara, S; Yasuda, K; Yoshida, S

    2015-01-01

    The PICO-LON project aims at search for cold dark matter by means of highly radio-pure and large volume NaI(Tl) scintillator. The NaI powder was purifed by chemical processing to remove lead isotopes and selecting a high purity graphite crucible. The concentrations of radioactive impurities of $^{226}$Ra and $^{228}$Th were effectively reduced to 58$\\pm$4 $\\mu$Bq/kg and 1.5$\\pm$1.9 $\\mu$Bq/kg, respectively. It should be remarked that the concentration of $^{210}$Pb, which is crucial for the sensitivity to dark matter, was reduced to 24$\\pm$2 $\\mu$Bq/kg. The total background rate at 10 keVee was as low as 8 keV$^{-1}$kg$^{-1}$day$^{-1}$, which was sufficiently low to search for dark matter. Further purification of NaI(Tl) ingot and future prospect of PICO-LON project is discussed.

  5. The Influence of Neutral Beam Injection on the Heating and Current Drive with Electron Cyclotron Wave on EAST

    Science.gov (United States)

    Chang, Pengxiang; Wu, Bin; Wang, Jinfang; Li, Yingying; Wang, Xiaoguang; Xu, Handong; Wang, Xiaojie; Liu, Yong; Zhao, Hailin; Hao, Baolong; Yang, Zhen; Zheng, Ting; Hu, Chundong

    2016-11-01

    Both neutral beam injection (NBI) and electron cyclotron resonance heating (ECRH) have been applied on the Experimental Advanced Superconducting Tokamak (EAST) in the 2015 campaign. In order to achieve more effective heating and current drive, the effects of NBI on the heating and current drive with electron cyclotron wave (ECW) are analyzed utilizing the code TORAY and experimental data in the shot #54411 and #54417. According to the experimental and simulated results, for the heating with ECW, NBI can improve the heating efficiency and move the power deposition place towards the inside of the plasma. On the other hand, for the electron cyclotron current drive (ECCD), NBI can also improve the efficiency of ECCD and move the place of ECCD inward. These results will be valuable for the center heating, the achievement of fully non-inductive current drive operation and the suppression of magnetohydrodynamic (MHD) instabilities with ECW on EAST or ITER with many auxiliary heating methods. supported by the National Magnetic Confinement Fusion Science Program of China (Nos. 2013GB101001 and 2014DFG61950) and National Natural Science Foundation of China (Nos. 11405212 and 11175211)

  6. Spur in pico-second time scales

    Energy Technology Data Exchange (ETDEWEB)

    Gopinathan, C.; Girija, G. (Bhabha Atomic Research Centre, Bombay (India). Chemistry Div.)

    1983-01-01

    The spur diffusion model of aqueous radiation chemistry, proposed in 1953, had run into difficulties with the development of pico-second pulse radiolysis in the late 1960s and early seventies. Using the same values for spur parameters, it was impossible to get good agreement with e/sup -/sub(aq) and OH decay in pico and nano second time scales as well as the steady state molecular product yield measurements. This inconsistency was removed by us by assuming that for a given number of dissociations, a number of radii values for the spur are possible, these radii values being related in a gaussian manner. This new approach proved highly successful in getting agreement between the predictions of the spur diffusion model and the pulse radiolysis results as well as the steady state molecular product yield measurements. Our computations have been extended to cover the entire range of spurs from a single dissociation spur to a thirty dissociation spur. Here again agreement with experimental results is good. This approach also gives interesting insights about the spur formation processes in pico and possibly femto second time scales. We have calculated rate constants for the reactions involving the 'precursor' of the hydrated electron with a number of ions.

  7. Simulation of ion beam induced current in radiation detectors and microelectronic devices.

    Energy Technology Data Exchange (ETDEWEB)

    Vizkelethy, Gyorgy

    2009-10-01

    Ionizing radiation is known to cause Single Event Effects (SEE) in a variety of electronic devices. The mechanism that leads to these SEEs is current induced by the radiation in these devices. While this phenomenon is detrimental in ICs, this is the basic mechanism behind the operation of semiconductor radiation detectors. To be able to predict SEEs in ICs and detector responses we need to be able to simulate the radiation induced current as the function of time. There are analytical models, which work for very simple detector configurations, but fail for anything more complex. On the other end, TCAD programs can simulate this process in microelectronic devices, but these TCAD codes costs hundreds of thousands of dollars and they require huge computing resources. In addition, in certain cases they fail to predict the correct behavior. A simulation model based on the Gunn theorem was developed and used with the COMSOL Multiphysics framework.

  8. Measurement of charged current deep inelastic scattering cross sections with a longitudinally polarised electron beam at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Chekanov, S.; Derrick, M.; Magill, S. [Argonne National Laboratory, IL (US)] (and others)

    2008-12-15

    Measurements of the cross sections for charged current deep inelastic scattering in e{sup -}p collisions with longitudinally polarised electron beams are presented. The measurements are based on a data sample with an integrated luminosity of 175 pb{sup -1} collected with the ZEUS detector at HERA at a centre-of-mass energy of 318 GeV. The total cross section is given for positively and negatively polarised electron beams. The differential cross-sections d{sigma}/dQ{sup 2}, d{sigma}/dx and d{sigma}/dy are presented for Q{sup 2}>200 GeV{sup 2}. The double-differential cross-section d{sup 2}{sigma}/dxdQ{sup 2} is presented in the kinematic range 280

  9. Comparative Studies on the Laser Damage Resistance of Ta2O5 and Nb2O5 Films Performed under Different Electron Beam Currents

    Institute of Scientific and Technical Information of China (English)

    XV Cheng; XU Lin-Min; ZHANG Han-Zhuo; QIANG Ying-Huai; ZHU Ya-Bo; LIU Jiong-Tian; SHAO Jian-Da

    2011-01-01

    @@ TaO and NbO films are deposited by conventional e-beam method under different electron beam currents.The optical transmittance, chemical composition, absorption, scattering, surface topography and laser-induced damage threshoM (LIDT) of the films are comparatively studied.It is shown that the increase of electron beam current results in a decrease of the optical transmittance and stoichiometry, whereas it increases the absorption, scattering and rms roughness for both TaO and NbO films.However, the LIDT increases first and then decreases with the increase of electron beam current.In addition, the annealing improves the optical transmittance, stoichiometry and LIDT for the two kinds of films.Both the effects of electron beam current and annealing on the LIDT can be mainly attributed to three factors: substoichiometric defects, structural defects and adhesive force.Furthermore, the comparative results indicate that the laser damage resistance of TaO is lower than that of NbO.%Ta2O5 and Nb2Os Rims are deposited by conventional e-beam method under different electron beam currents. The optical transmittance, chemical composition, absorption, scattering, surface topography and laser-induced damage threshold (LIDT) of the dims are comparatively studied. It is shown that the increase of electron beam current results in a decrease of the optical transmittance and stoichiometry, whereas it increases the absorption, scattering and rms roughness for both Ta2O5, and Ni2O5 Sims. However, the LIDT increases first and then decreases with the increase of electron beam current. In addition, the annealing improves the optical transmittance, stoichiometry and LIDT for the two kinds of Sims. Both the effects of electron beam current and annealing on the LIDT can be mainly attributed to three factors: substoichiometric defects, structural defects and adhesive force. Furthermore, the comparative results indicate that the laser damage resistance of Ta2O5 is lower than that ofNb2O5.

  10. Chosen Aspects Of Investigations Of Solar Cells With The Laser Beam Induced Current Technique

    Directory of Open Access Journals (Sweden)

    Chrobak Łukasz Bartłomiej

    2015-06-01

    Full Text Available This paper presents maps of spatial distributions of the short circuit current Isc(x,y and the open circuit voltage Uoc(x,y of the investigated low cost solar cells. Visible differences in values of these parameters were explained by differences in the serial and shunt resistances determined for different points of solar cells from measurements of I–V characteristics. The spectral dependence of the photo voltage of solar cell is also shown, discussed and interpreted in the model of amorphous and crystal silicon.

  11. Improvements in time resolution and signal-to-noise ratio in a compact pico-second pulse radiolysis system

    Energy Technology Data Exchange (ETDEWEB)

    Nagai, Hiroyuki [Advanced Research Institute for Science and Engineering, Waseda University, 17 Kikuicho, Shinjuku-ku, Tokyo 162-0044 (Japan)], E-mail: physik-albert@suou.waseda.jp; Kawaguchi, Masaaki; Sakaue, Kazuyuki; Komiya, Keita; Nomoto, Tomoaki; Kamiya, Yoshio; Hama, Yoshimasa; Washio, Masakazu [Advanced Research Institute for Science and Engineering, Waseda University, 17 Kikuicho, Shinjuku-ku, Tokyo 162-0044 (Japan); Ushida, Kiminori [The Institute of Physical and Chemical Research, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Kashiwagi, Shigeru [The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047 (Japan); Kuroda, Ryunosuke [National Institute of Advanced Industrial Science and Technology, AIST Tsukuba Central 2, Tsukuba, Ibaraki 305-8568 (Japan)

    2007-12-15

    A compact pico-second pulse radiolysis system has been developing at Waseda University for studying primary processes in radiation chemistry. The system is composed of a photo-injector system and a pico-second all-solid-state laser system. An infrared (IR) and an ultraviolet (UV) laser pulses are obtained from mode-locked Nd:YLF laser system and used for generation of the white light continuum as a probe light and the irradiation to the Cu cathode of a photo-cathode RF-gun, respectively. To improve signal-to-noise (S/N) ratio and time resolution of this pulse radiolysis system, we optimized both probe light and pump electron beam. As a result, our pico-second pulse radiolysis system has been enough to study the primary processes of radiation chemistry. The experimental results and the improvements of our system are described in this paper.

  12. Improvement of Wear Resistance of Magnesium Alloy AZ91HP by High Current Pulsed Electron Beam Treatment

    Institute of Scientific and Technical Information of China (English)

    GAO Bo; HAO Sheng-zhi; ZOU Jian-xin; JIANG Li-min; ZHOU Ji-yang; DONG Chuang

    2004-01-01

    Surface modification of magnesium alloy AZ91HP (9wt%Al, 0.5wt%Zn, 0.5wt%Mn, Mg remaining percentage) by high current pulsed electron beam (HCPEB) treatment was studied in this paper. The secondary phase Mg17Al12 is nearly completely dissolved and as a result, a super-saturated solid solution forms on the re-melted surface.The microhardness is increased both in and far beyond the heat-affected zone (HAZ), reaching about 250μm.Measurements on sliding wear have shown that the wear resistance of the treated samples was improved by a factor of about 2.4 as compared to the as-received sample. It is also found that the sliding wear resistance can be further improved by surface alloying with TiN.

  13. Numerical simulation of thermal-mechanical process of Al-Si-Pb alloy treated by high current pulsed electron beam

    Institute of Scientific and Technical Information of China (English)

    L(U) Xiao-xia; LI Rong-guang; AN Jian

    2006-01-01

    The modified microstructure of Al-Si-Pb alloys irradiated by high current electron beam (HCPEB) reveals three distinct regions: a molten zone, an overlapped zone of heat-affected and quasistatic thermal stress-affected zone, and a transition zone followed by the substrate. The hardness and wear properties of the alloys were significantly improved. To better understand these changes in microstructure and properties, the physical model for the simulation of temperature and quasistatic stress fields was established. Based on experimental investigation and physical models, the temperature field and stress field were simulated for Al-Si-Pb alloy. The starting melting position, largest crater depth, melting layer thickness, and quasistatic stress distribution were obtained. These results reveal the mechanism of crater formation on the surface and improvement of hardness and wear resistance.

  14. Surface Nanocrystallization of 3Cr13 Stainless Steel Induced by High-Current Pulsed Electron Beam Irradiation

    Directory of Open Access Journals (Sweden)

    Zhiyong Han

    2013-01-01

    Full Text Available The nanocrystalline surface was produced on 3Cr13 martensite stainless steel surface using high-current pulsed electron beam (HCPEB technique. The structures of the nanocrystallized surface were characterized by X-ray diffraction and electron microscopy. Two nanostructures consisting of fine austenite grains (50–150 nm and very fine carbides precipitates are formed in melted surface layer after multiple bombardments via dissolution of carbides and crater eruption. It is demonstrated that the dissolution of the carbides and the formation of the supersaturated Fe (C solid solution play a determining role on the microstructure evolution. Additionally, the formation of fine austenite structure is closely related to the thermal stresses induced by the HCPEB irradiation. The effects of both high carbon content and high value of stresses increase the stability of the austenite, which leads to the complete suppression of martensitic transformation.

  15. Impurity heterogeneity in natural pyrite and its relation to internal electric fields mapped using remote laser beam induced current

    Energy Technology Data Exchange (ETDEWEB)

    Laird, Jamie S., E-mail: csirojamie@gmail.com [CSIRO, Earth Science and Resource Engineering, Clayton, Victoria (Australia); Centre of Excellence in Ore Deposits (CODES), University of Tasmania, Hobart, Tasmania (Australia); School of Physics, University of Melbourne, Parkville 3010, Victoria (Australia); Large, Ross [Centre of Excellence in Ore Deposits (CODES), University of Tasmania, Hobart, Tasmania (Australia); Ryan, Chris G. [CSIRO, Earth Science and Resource Engineering, Clayton, Victoria (Australia); Centre of Excellence in Ore Deposits (CODES), University of Tasmania, Hobart, Tasmania (Australia); School of Physics, University of Melbourne, Parkville 3010, Victoria (Australia)

    2013-07-01

    Regions of band-bending in naturally occurring semiconducting sulfides are thought to drive electrochemical reactions with passing fluids. Metal bearing fluids within the right pH range interact with the electric fields at the surface resulting in precious metal ore genesis, even in under-saturated solutions. Metal reduction at the surface occurs via field assisted electron transfer from the semiconductor bulk to the ion in solution via surface states. Better understanding the role these regions and their texturing play on nucleating ore growth requires imaging of electric field distributions near the sulfide surface and correlation with underlying elemental heterogeneity. In this paper we discuss PIXE measurements made on the CSIRO Nuclear Microprobe and correlate elemental maps with laser beam induced current maps of the electric field distribution.

  16. Laser-beam-induced current mapping evaluation of porous silicon-based passivation in polycrystalline silicon solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Rabha, M. Ben; Bessais, B. [Laboratoire de Nanomateriaux et des Systemes pour l' Energie, Centre de Recherches et des Technologies de l' Energie - Technopole de Borj-Cedria BP 95, 2050 Hammam-Lif (Tunisia); Dimassi, W.; Bouaicha, M.; Ezzaouia, H. [Laboratoire de photovoltaique, des semiconducteurs et des nanostructures, Centre de Recherches et des Technologies de l' Energie - Technopole de Borj-Cedria BP 95, 2050 Hammam-Lif (Tunisia)

    2009-05-15

    In the present work, we report on the effect of introducing a superficial porous silicon (PS) layer on the performance of polycrystalline silicon (pc-Si) solar cells. Laser-beam-induced current (LBIC) mapping shows that the PS treatment on the emitter of pc-Si solar cells improves their quantum response and reduce the grain boundaries (GBs) activity. After the porous silicon treatment, mapping investigation shows an enhancement of the LBIC and the internal quantum efficiency (IQE), due to an improvement of the minority carrier diffusion length and the passivation of recombination centers at the GBs as compared to the reference substrate. It was quantitatively shown that porous silicon treatment can passivate both the grains and GBs. (author)

  17. Influence of electron-beam lithography exposure current level on the transport characteristics of graphene field effect transistors

    Science.gov (United States)

    Kang, Sangwoo; Movva, Hema C. P.; Sanne, Atresh; Rai, Amritesh; Banerjee, Sanjay K.

    2016-03-01

    Many factors have been identified to influence the electrical transport characteristics of graphene field-effect transistors. In this report, we examine the influence of the exposure current level used during electron beam lithography (EBL) for active region patterning. In the presence of a self-assembled hydrophobic residual layer generated by oxygen plasma etching covering the top surface of the graphene channel, we show that the use of low EBL current level results in higher mobility, lower residual carrier density, and charge neutrality point closer to 0 V, with reduced device-to-device variations. We show that this correlation originates from the resist heating dependent release of radicals from the resist material, near its interface with graphene, and its subsequent trapping by the hydrophobic polymer layer. Using a general model for resist heating, we calculate the difference in resist heating for different EBL current levels. We further corroborate our argument through control experiments, where radicals are either intentionally added or removed by other processes. We also utilize this finding to obtain mobilities in excess of 18 000 cm2/V s on silicon dioxide substrates. We believe these results are applicable to other 2D materials such as transition metal dichalcogenides and nanoscale devices in general.

  18. Relativistic high-current electron-beam stopping-power characterization in solids and plasmas: collisional versus resistive effects.

    Science.gov (United States)

    Vauzour, B; Santos, J J; Debayle, A; Hulin, S; Schlenvoigt, H-P; Vaisseau, X; Batani, D; Baton, S D; Honrubia, J J; Nicolaï, Ph; Beg, F N; Benocci, R; Chawla, S; Coury, M; Dorchies, F; Fourment, C; d'Humières, E; Jarrot, L C; McKenna, P; Rhee, Y J; Tikhonchuk, V T; Volpe, L; Yahia, V

    2012-12-21

    We present experimental and numerical results on intense-laser-pulse-produced fast electron beams transport through aluminum samples, either solid or compressed and heated by laser-induced planar shock propagation. Thanks to absolute K(α) yield measurements and its very good agreement with results from numerical simulations, we quantify the collisional and resistive fast electron stopping powers: for electron current densities of ≈ 8 × 10(10) A/cm(2) they reach 1.5 keV/μm and 0.8 keV/μm, respectively. For higher current densities up to 10(12)A/cm(2), numerical simulations show resistive and collisional energy losses at comparable levels. Analytical estimations predict the resistive stopping power will be kept on the level of 1 keV/μm for electron current densities of 10(14)A/cm(2), representative of the full-scale conditions in the fast ignition of inertially confined fusion targets.

  19. Influence of electron-beam lithography exposure current level on the transport characteristics of graphene field effect transistors

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Sangwoo, E-mail: swk1230@utexas.edu; Movva, Hema C. P.; Sanne, Atresh; Rai, Amritesh; Banerjee, Sanjay K. [Microelectronics Research Center, The University of Texas at Austin, Austin, Texas 78758 (United States)

    2016-03-28

    Many factors have been identified to influence the electrical transport characteristics of graphene field-effect transistors. In this report, we examine the influence of the exposure current level used during electron beam lithography (EBL) for active region patterning. In the presence of a self-assembled hydrophobic residual layer generated by oxygen plasma etching covering the top surface of the graphene channel, we show that the use of low EBL current level results in higher mobility, lower residual carrier density, and charge neutrality point closer to 0 V, with reduced device-to-device variations. We show that this correlation originates from the resist heating dependent release of radicals from the resist material, near its interface with graphene, and its subsequent trapping by the hydrophobic polymer layer. Using a general model for resist heating, we calculate the difference in resist heating for different EBL current levels. We further corroborate our argument through control experiments, where radicals are either intentionally added or removed by other processes. We also utilize this finding to obtain mobilities in excess of 18 000 cm{sup 2}/V s on silicon dioxide substrates. We believe these results are applicable to other 2D materials such as transition metal dichalcogenides and nanoscale devices in general.

  20. Measurement of Neutral Current Neutral Pion Production on Carbon in a Few-GeV Neutrino Beam

    Energy Technology Data Exchange (ETDEWEB)

    Kurimoto, Yoshinori [Kyoto Univ. (Japan)

    2010-01-01

    Understanding of the π0 production via neutrino-nucleus neutral current interaction in the neutrino energy region of a few GeV is essential for the neutrino oscillation experiments. In this thesis, we present a study of neutral current π0 production from muon neutrinos scattering on a polystyrene (C8H8) target in the SciBooNE experiment. All neutrino beam data corresponding to 0.99 × 1020 protons on target have been analyzed. We have measured the cross section ratio of the neutral current π0 production to the total charge current interaction and the π0 kinematic distribution such as momentum and direction. We obtain [7.7 ± 0.5(stat.) ± 0.5(sys.)] × 10-2 as the ratio of the neutral current neutral pion production to total charged current cross section; the mean energy of neutrinos producing detected neutral pions is 1.1 GeV. The result agrees with the Rein- Sehgal model, which is generally used for the Monte Carlo simulation by many neutrino oscillation experiments. We achieve less than 10 % uncertainty which is required for the next generation search for νµ → νe oscillation. The spectrum shape of the π0 momentum and the distribution of the π0 emitted angle agree with the prediction, which means that not only the Rein-Sehgal model but also the intra-nuclear interaction models describe our data well. We also measure the ratio of the neutral current coherent pion production to total charged current cross section to be (1.17 ± 0.23 ) × 10-2 based on the Rein and Sehgal model. The result gives the evidence for non-zero coherent pion production via neutral current interaction at the mean neutrino energy of 1.0 GeV.

  1. Expression profiles of antimicrobial peptides (AMPs) and their regulation by Relish

    Institute of Scientific and Technical Information of China (English)

    WANG Dongdong; LI Fuhua; LI Shihao; WEN Rong; XIANG Jianhai

    2012-01-01

    Antimicrobial peptides (AMPs),as key immune effectors,play important roles in the innate immune system of invertebrates.Different types of AMPs,including Penaeidin,Crustin,ALF (antilipopolysaccharide factor) have been identified in different penaeid shrimp; however,systematic analyses on the function of different AMPs in shrimp responsive to different types of bacteria are very limited.In this study,we analyzed the expression profiles of AMPs in the Chinese shrimps,Fenneropenaeus chinensis,simultaneously by real-time RT-PCR (reverse transcription-polymerase chain reaction) when shrimp were challenged with Micrococcus lysodeikticus (Gram-positive,G+) or Vibrio anguillarium (Gram-negative,G).Different AMPs showed different expression profiles when shrimp were injected with one type of bacterium,and one AMP also showed different expression profiles when shrimp were challenged with different bacteria.Furthermore,the expression of these AMPs showed temporal expression profiles,suggesting that different AMPs function coordinately in bacteria-infected shrimp.An RNA interference approach was used to study the function of the Relish transcription factor in regulating the transcription of different AM Ps.The current study showed that Relish could regulate the transcription of different AMPs in shrimp.Differential expression profiles of AMPs in shrimp injected with different types of bacteria indicated that a complicated antimicrobial response network existed in shrimp.These data contribute to our understanding of immunity in shrimp and may provide a strategy for the control of disease in shrimp.

  2. A Measurement of Neutrino Charged Current Interactions and a Search for Muon Neutrino Disappearance with the Fermilab Booster Neutrino Beam

    Energy Technology Data Exchange (ETDEWEB)

    Nakajima, Yasuhiro [Kyoto Univ. (Japan)

    2011-01-01

    In this thesis, we report on a measurement of muon neutrino inclusive charged current interactions on carbon in the few GeV region, using the Fermilab Booster Neutrino Beam. The all neutrino mode data collected in the SciBooNE experiment is used for this analysis. We collected high-statistics CC interaction sample at SciBooNE, and extracted energy dependent inclusive charged current interaction rates and cross sections for a wide energy range from 0.25 GeV to ~3 GeV. We measure the interaction rates with 6-15% precision, and the cross sections with 10-30% precision. We also made an energy integrated measurements, with the precisions of 3% for the rate, and 8% for the cross section measurements. This is the first measurement of the CC inclusive cross section on carbon around 1 GeV. This inclusive interaction measurement is nearly free from effects of hadron re-interactions in the nucleus. Hence, it is complementary to other exclusive cross section measurements, and essential to understand the neutrino interaction cross sections in the few GeV region, which is relevant to ongoing and future neutrino oscillation experiments. This analysis also provides the normalization for SciBooNE's previous cross section ratio measurements for charged current coherent pion production and neutral current neutral pion production. Then, a precise comparison between our previous measurements and the model predictions becomes possible. The result of the interaction rate measurement is used to constrain the product of the neutrino flux and the cross section at the other experiment on the Fermilab Booster Neutrino Beam: Mini-BooNE. We conducted a search for short-baseline muon neutrino disappearance using data both from SciBooNE and MiniBooNE, to test a possible neutrino oscillation with sterile neutrinos which is suggested by the LSND experiment. With this constraint by SciBooNE, we significantly reduced the flux and the cross section uncertainties at MiniBooNE, and achieved the

  3. Beam loading compensation for the NLC low frequency linacs

    Energy Technology Data Exchange (ETDEWEB)

    Li, Z.; Miller, R.; Farkas, D.; Raubenheimer, T.; Tang, H.; Yeremian, D.

    1997-03-01

    The NLC low rf linacs are heavily loaded by a beam of about 130 ns in macropulse length (90 bunches) and a current up to 2.75 Amps. Beam loading voltage generates a large energy spread along the bunch train. This energy spread is critical for lattice design and, if not properly compensated, induces emittance growth and in turn lowers the luminosity of the machine. In this paper, the authors study the {Delta}F and {Delta}T beam loading compensation techniques for the NLC low rf linacs. They will apply these methods to the NLC low rf linacs to demonstrate the efficacy of these methods. Finally, they discuss a hybrid {Delta}T + {Delta}F method to improve the efficiency of beam loading compensation.

  4. Complex reduction coefficient for a cylindrical electron beam with variable amplitude of the variable current component in the TWT

    Directory of Open Access Journals (Sweden)

    Chasnyk V. I.

    2013-12-01

    Full Text Available The conventional approach to calculating the space charge for the traveling-wave tube (TWT with phase velocity jumps is to use the same values of the depression coefficient as the ones for homogeneous helical TWTs. However, if the variable component of the exciting current in the expressions for determining the reduction coefficient is changed in amplitude, then the reduction factor is a complex value. Perhaps the neglect of this fact can significantly affect the volume discharge calculated value, and hence the non-synchronization parameter, for those of its values, which are characteristic of the TWT with a phase velocity jump. In this paper, formulas has been obtained for computation of real and imaginary parts of the complex reduction coefficient for a cylindrical electrons beam with exponential variable amplitude of variable current component in the TWT. Influence of complex reduction coefficient on the parameters of the TWT operating in the linear mode is estimated. It is shown that taking into account the imaginary part of the reduction coefficient for linear operation of the TWT makes it possible to change the estimated amount of space charge 1.5 to 2 times, which in its turn has quite a strong effect on the formation of the initial conditions of the nonlinear mode and, subsequently, on the output characteristics of the TWT.

  5. Electronic regulation of the SPS extraction quadrupole current pulse shape for improved stability of the extracted beam

    CERN Document Server

    Carlier, E; Vossenberg, Eugène B; CERN. Geneva. SPS and LEP Division

    1996-01-01

    In order to minimise the event pile-up and therefore optimise the detection efficiency, Chorus and Nomad experiments ask for a long and rectangular spill profile. At present the fast-slow extractio n is generated by driving the beam into a quadrupolar-octopolar resonance by exciting a quadrupole magnet with a semi-trapezoidal current [1]. The trapezoidal pulse shape is obtained by dischargin g a capacitor into the magnet coils. After a few milliseconds of undamped discharge a fixed resistor is switched into the circuit. The attenuation is then higher and the sine wave continues with a lower gradient. The two gradients can be adjusted by varying the initial capacitor voltage and the time at which the resistor is switched into the circuit. A further degree of freedom in determini ng the spill shape has been added by allowing the possibility of changing the second slope value independently of the initial conditions. This task is achieved by means of a variable current sour ce added in parallel to the fixed resis...

  6. Growth of doped silicon nanowires by pulsed laser deposition and their analysis by electron beam induced current imaging

    Energy Technology Data Exchange (ETDEWEB)

    Eisenhawer, B; Berger, A; Christiansen, S [Institute of Photonic Technology, Albert-Einstein-Strasse 9, 07745 Jena (Germany); Zhang, D; Clavel, R [Laboratory of Robotic Systems, Ecole Polytechnique Federale de Lausanne (EPFL), Station 9, CH-1015 Lausanne (Switzerland); Michler, J, E-mail: bjoern.eisenhawer@ipht-jena.de [Mechanics of Materials and Nanostructures Laboratory, EMPA-Materials Science and Technology, Feuerwerkstrasse 39, CH-3602 Thun (Switzerland)

    2011-02-18

    Doped silicon nanowires (NWs) were epitaxially grown on silicon substrates by pulsed laser deposition following a vapour-liquid-solid process, in which dopants together with silicon atoms were introduced into the gas phase by laser ablation of lightly and highly doped silicon target material. p-n or p{sup ++}-p junctions located at the NW-silicon substrate interfaces were thus realized. To detect these junctions and visualize them the electron beam induced current technique and two-point probe current-voltage measurements were used, based on nanoprobing individual silicon NWs in a scanning electron microscope. Successful silicon NW doping by pulsed laser deposition of doped target material could experimentally be demonstrated. This doping strategy compared to the commonly used doping from the gas phase during chemical vapour deposition is evaluated essentially with a view to potentially overcoming the limitations of chemical vapour deposition doping, which shows doping inhomogeneities between the top and bottom of the NW as well as between the core and shell of NWs and structural lattice defects, especially when high doping levels are envisaged. The pulsed laser deposition doping technique yields homogeneously doped NWs and the doping level can be controlled by the choice of the target material. As a further benefit, this doping procedure does not require the use of poisonous gases and may be applied to grow not only silicon NWs but also other kinds of doped semiconductor NWs, e.g. group III nitrides or arsenides.

  7. Multi-dimensional collective effects in high-current relativistic beams relevant to High Density Laboratory Plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Shvets, Gennady

    2014-05-09

    In summary, an analytical model describing the self-pinching of a relativistic charge-neutralized electron beam undergoing the collisionless Weibel instability in an overdense plasma has been developed. The model accurately predicts the final temperature and size of the self-focused filament. It is found that the final temperature is primarily defined by the total beam’s current, while the filament’s radius is shown to be smaller than the collisionless skin depth in the plasma and primarily determined by the beam’s initial size. The model also accurately predicts the repartitioning ratio of the initial energy of the beam’s forward motion into the magnetic field energy and the kinetic energy of the surrounding plasma. The density profile of the final filament is shown to be a superposition of the standard Bennett pinch profile and a wide halo surrounding the pinch, which contains a significant fraction of the beam’s electrons. PIC simulations confirm the key assumption of the analytic theory: the collisionless merger of multiple current filaments in the course of the Weibel Instability provides the mechanism for Maxwellization of the beam’s distribution function. Deviations from the Maxwell-Boltzmann distribution are explained by incomplete thermalization of the deeply trapped and halo electrons. It is conjectured that the simple expression derived here can be used for understanding collsionless shock acceleration and magnetic field amplification in astrophysical plasmas.

  8. Multimodal backside imaging of a microcontroller using confocal laser scanning and optical-beam-induced current imaging

    Science.gov (United States)

    Finkeldey, Markus; Göring, Lena; Schellenberg, Falk; Brenner, Carsten; Gerhardt, Nils C.; Hofmann, Martin

    2017-02-01

    Microscopy imaging with a single technology is usually restricted to a single contrast mechanism. Multimodal imaging is a promising technique to improve the structural information that could be obtained about a device under test (DUT). Due to the different contrast mechanisms of laser scanning microscopy (LSM), confocal laser scanning microscopy (CLSM) and optical beam induced current microscopy (OBICM), a combination could improve the detection of structures in integrated circuits (ICs) and helps to reveal their layout. While OBIC imaging is sensitive to the changes between differently doped areas and to semiconductor-metal transitions, CLSM imaging is mostly sensitive to changes in absorption and reflection. In this work we present the implementation of OBIC imaging into a CLSM. We show first results using industry standard Atmel microcontrollers (MCUs) with a feature size of about 250nm as DUTs. Analyzing these types of microcontrollers helps to improve in the field of side-channel attacks to find hardware Trojans, possible spots for laser fault attacks and for reverse engineering. For the experimental results the DUT is placed on a custom circuit board that allows us to measure the current while imaging it in our in-house built stage scanning microscope using a near infrared (NIR) laser diode as light source. The DUT is thinned and polished, allowing backside imaging through the Si-substrate. We demonstrate the possibilities using this optical setup by evaluating OBIC, LSM and CLSM images above and below the threshold of the laser source.

  9. Physical mechanism of beam halo-chaos formation for high-current proton beam in a periodic-focusing channels and a nonlinear control strategy

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The physical mechanism of the halo-chaos formation for a high intensity proton beam in a periodic-fo cusing channel is analyzed using the transfer mahix theory and a qualiative analysis method.Particles-in-cell simula tims are further used to explore the mechanism of the beam halo-chaos fomation, which concerns not only with thc non linear effect of the beam space charge but also with the lransverse energy exchange belween the particles and the particle core. as well as the chaos generated by the nonlinear resonance ovcrlap. A nonlinear control method is proposed for con trolling tie haho-chaos. Simulation results show lhal the melhod is efhclivc. Somc potemlial applications of the halo chaos conlrol in experimenls are discussed.

  10. Electrostatic solitary waves in current layers: from Cluster observations during a super-substorm to beam experiments at the LAPD

    Directory of Open Access Journals (Sweden)

    J. S. Pickett

    2009-06-01

    Full Text Available Electrostatic Solitary Waves (ESWs have been observed by several spacecraft in the current layers of Earth's magnetosphere since 1982. ESWs are manifested as isolated pulses (one wave period in the high time resolution waveform data obtained on these spacecraft. They are thus nonlinear structures generated out of nonlinear instabilities and processes. We report the first observations of ESWs associated with the onset of a super-substorm that occurred on 24 August 2005 while the Cluster spacecraft were located in the magnetotail at around 18–19 RE and moving northward from the plasma sheet to the lobes. These ESWs were detected in the waveform data of the WBD plasma wave receiver on three of the Cluster spacecraft. The majority of the ESWs were detected about 5 min after the super-substorm onset during which time 1 the PEACE electron instrument detected significant field-aligned electron fluxes from a few 100 eV to 3.5 keV, 2 the EDI instrument detected bursts of field-aligned electron currents, 3 the FGM instrument detected substantial magnetic fluctuations and the presence of Alfvén waves, 4 the STAFF experiment detected broadband electric and magnetic waves, ion cyclotron waves and whistler mode waves, and 5 CIS detected nearly comparable densities of H+ and O+ ions and a large tailward H+ velocity. We compare the characteristics of the ESWs observed during this event to those created in the laboratory at the University of California-Los Angeles Plasma Device (LAPD with an electron beam. We find that the time durations of both space and LAPD ESWs are only slightly larger than the respective local electron plasma periods, indicating that electron, and not ion, dynamics are responsible for generation of the ESWs. We have discussed possible mechanisms for generating the ESWs in space, including the beam and kinetic Buneman type instabilities and the acoustic instabilities. Future studies will examine these mechanisms in

  11. Neuromagnetic effects of pico-Tesla stimulation.

    Science.gov (United States)

    Troebinger, Luzia; Anninos, Photios; Barnes, Gareth

    2015-09-01

    We used a double-blind experimental design to look for an effect of pico-Tesla magnetic stimulation in healthy subjects. Pico-Tesla stimulation is thought to increase the dominant frequency of 2-7 Hz oscillations in the human brain. We used magnetoencephalography to measure resting state brain activity. Each subject had two separate recording sessions consisting of three runs in between which they were given real or sham pT stimulation. We then tried to predict the real and sham stimulation sessions based on changes in the mean peak frequency in the 2-7 Hz band. Our predictions for these individual runs were 8 out of 14 at chance level (p = 0.39). After unblinding, we found no significant effect (p = 0.11) of an increase in the frequency range (2-7 Hz) across the subject group. Finally, we performed a Bayesian model comparison between the effect size predicted from previous clinical studies and a null model. Even though this study had a sensitivity advantage of at least one order of magnitude over previous work, we found the null model to be significantly (2000 times) more likely.

  12. Embarazo ectópico abdominal

    Directory of Open Access Journals (Sweden)

    Karen Luz Torres Rojas

    2015-12-01

    Full Text Available La incidencia de embarazo ectópico ha aumentado en los últimos años hasta 1:43 recién nacidos. La variedad abdominal es una de las menos frecuentes, su incidencia es de 1:10mil  nacidos vivos. El 1% de los embarazos ectópicos son abdominales y la implantación en el epiplón es una rara entidad. Pueden clasificarse como primarios o secundarios en función de que se originen o no en la cavidad peritoneal. Se presenta un caso de embarazo abdominal primario, localizado en cara posterior del útero y recto, con edad gestacional 16 semanas y feto muerto, en una paciente de 25 años, atendida en el Hospital General “Dr. Ernesto Guevara de la Serna”, con antecedentes de salud, G0 P0 A0, con método anticonceptivo DIU retirado seis meses antes. Se trata de un embarazo abdominal primario, puesto que la anatomía patológica informó ausencia de invasión trofloblástica en la trompa izquierda. El manejo placentario en este caso no permitió realizar la remoción completa de la misma. El seguimiento ecográfico y  control de gonadotropinas evidenció una evolución favorable de la paciente, sin requerir manejo de metotrexate.

  13. Parametic Study of the current limit within a single driver-scaletransport beam line of an induction Linac for Heavy Ion Fusion

    Energy Technology Data Exchange (ETDEWEB)

    Prost, Lionel Robert [Univ. of California, Berkeley, CA (United States)

    2004-01-01

    The High Current Experiment (HCX) at Lawrence Berkeley National Laboratory is part of the US program that explores heavy-ion beam as the driver option for fusion energy production in an Inertial Fusion Energy (IFE) plant. The HCX is a beam transport experiment at a scale representative of the low-energy end of an induction linear accelerator driver. The primary mission of this experiment is to investigate aperture fill factors acceptable for the transport of space-charge-dominated heavy-ion beams at high intensity (line charge density ~0.2 μC/m) over long pulse durations (4 μs) in alternating gradient focusing lattices of electrostatic or magnetic quadrupoles. This experiment is testing transport issues resulting from nonlinear space-charge effects and collective modes, beam centroid alignment and steering, envelope matching, image charges and focusing field nonlinearities, halo and, electron and gas cloud effects. We present the results for a coasting 1 MeV K+ ion beam transported through ten electrostatic quadrupoles. The measurements cover two different fill factor studies (60% and 80% of the clear aperture radius) for which the transverse phase-space of the beam was characterized in detail, along with beam energy measurements and the first halo measurements. Electrostatic quadrupole transport at high beam fill factor (~80%) is achieved with acceptable emittance growth and beam loss. We achieved good envelope control, and re-matching may only be needed every ten lattice periods (at 80% fill factor) in a longer lattice of similar design. We also show that understanding and controlling the time dependence of the envelope parameters is critical to achieving high fill factors, notably because of the injector and matching section dynamics.

  14. High-current Standing Wave Linac With Gyrocon Power Source

    CERN Document Server

    Karliner, M M; Makarov, I G; Nezhevenko, O A; Ostreiko, G N; Persov, B Z; Serdobintsev, G V

    2004-01-01

    A gyrocon together with high-voltage 1.5 MeV accelerator ELIT-3A represents a power generator at 430 MHz serving for linear electron accelerator pulse driving. The facility description and results of calorimetric measurements of ELIT-3A electron beam power and accelerated beam at the end of accelerator are presented in the paper. 2.2 amps of pulsed current have been obtained at electron energy of 20 MeV. The achieved energy conversion efficiency is about 55%.

  15. Exchange protein activated by cAMP (Epac) mediates cAMP-dependent but protein kinase A-insensitive modulation of vascular ATP-sensitive potassium channels.

    Science.gov (United States)

    Purves, Gregor I; Kamishima, Tomoko; Davies, Lowri M; Quayle, John M; Dart, Caroline

    2009-07-15

    Exchange proteins directly activated by cyclic AMP (Epacs or cAMP-GEF) represent a family of novel cAMP-binding effector proteins. The identification of Epacs and the recent development of pharmacological tools that discriminate between cAMP-mediated pathways have revealed previously unrecognized roles for cAMP that are independent of its traditional target cAMP-dependent protein kinase (PKA). Here we show that Epac exists in a complex with vascular ATP-sensitive potassium (KATP) channel subunits and that cAMP-mediated activation of Epac modulates KATP channel activity via a Ca2+-dependent mechanism involving the activation of Ca2+-sensitive protein phosphatase 2B (PP-2B, calcineurin). Application of the Epac-specific cAMP analogue 8-pCPT-2'-O-Me-cAMP, at concentrations that activate Epac but not PKA, caused a 41.6 +/- 4.7% inhibition (mean +/- S.E.M.; n = 7) of pinacidil-evoked whole-cell KATP currents recorded in isolated rat aortic smooth muscle cells. Importantly, similar results were obtained when cAMP was elevated by addition of the adenylyl cyclase activator forskolin in the presence of the structurally distinct PKA inhibitors, Rp-cAMPS or KT5720. Activation of Epac by 8-pCPT-2'-O-Me-cAMP caused a transient 171.0 +/- 18.0 nM (n = 5) increase in intracellular Ca2+ in Fura-2-loaded aortic myocytes, which persisted in the absence of extracellular Ca2+. Inclusion of the Ca2+-specific chelator BAPTA in the pipette-filling solution or preincubation with the calcineurin inhibitors, cyclosporin A or ascomycin, significantly reduced the ability of 8-pCPT-2'-O-Me-cAMP to inhibit whole-cell KATP currents. These results highlight a previously undescribed cAMP-dependent regulatory mechanism that may be essential for understanding the physiological and pathophysiological roles ascribed to arterial KATP channels in the control of vascular tone and blood flow.

  16. Improvement of wear resistance of AZ31 and AZ91HP by high current pulsed electron beam treatment

    Institute of Scientific and Technical Information of China (English)

    GAO Bo; HAO Sheng-zhi; DONG Chuang; TU Gan-feng

    2005-01-01

    The surface modification of magnesium alloys (AZ31 and AZ91HP) was studied by a high current pulsed electron beam(HCPEB). The results show that the cross-sectional microhardness of treated samples increases not only in the heat affected zone(HAZ), but also beyond HAZ, reaching over 250 μm. This is due to the action of quasi-static thermal stress and the shock thermal stress wave with materials, which result in its fast deformation on the surface layer and so increases microhardness. For the AZ91HP alloy, a nearly complete dissolution of the intermetallic phase Mg17Al12 is observed, and a super-saturated solid solution forms on the re-melted surface, which is due to the solute trapping effect during the fast solidification process. Measurements on sliding wear show that wear resistance is improved by approximately 5.6 and 2.4 times for the AZ31 and AZ91HP respectively, as compared with as-received samples.

  17. Grain refinement, hardening and metastable phase formation by high current pulsed electron beam (HCPEB) treatment under heating and melting modes

    Energy Technology Data Exchange (ETDEWEB)

    Grosdidier, T., E-mail: Thierry.grosdidier@univ-metz.f [Laboratoire d' Etude des Textures et Applications aux Materiaux (LETAM, CNRS 3143), Universite Paul Verlaine-Metz, Ile du Saulcy, 57045 Metz (France); Lab of Materials Modification by Laser, Ion and Electron Beams and School of Materials Science and Engineering, Dalian University of Technology, Dalian 116024 (China); Zou, J.X. [Laboratoire d' Etude des Textures et Applications aux Materiaux (LETAM, CNRS 3143), Universite Paul Verlaine-Metz, Ile du Saulcy, 57045 Metz (France); Bolle, B. [Laboratoire d' Etude des Textures et Applications aux Materiaux (LETAM, CNRS 3143), ENIM, Ile du Saulcy, 57045 Metz (France); Hao, S.Z.; Dong, C. [Lab of Materials Modification by Laser, Ion and Electron Beams and School of Materials Science and Engineering, Dalian University of Technology, Dalian 116024 (China)

    2010-08-15

    High current pulsed electron beam is a recently developed technique for surface modification. The pulsed electron irradiation introduces concentrated energy depositions in the thin surface layer of the treated materials, giving rise to an extremely fast heating and subsequent rapid cooling of the surface together with the formation of dynamic stress waves. Improved surface properties (hardness, corrosion resistance) can be obtained under the 'melting' mode when the top surface is melted and rapidly solidified (10{sup 7} K/s). In steels, this is essentially the result of nanostructures formed from the highly undercooled melt, melt surface purification, strain hardening induced by the thermal stress waves as well as metastable phase selections in the rapidly solidified melted layers. The use of the 'heating' mode is less conventional, combining effects of the heavy deformation and recrystallization/recovery mechanisms. A detailed analysis of a FeAl alloy demonstrates grain size refinement, hardening, solid-state enhanced diffusion and texture modification without modification of the surface geometry.

  18. Halo Evolution of Hypereutectic Al-17.5Si Alloy Treated with High-Current Pulsed Electron Beam

    Directory of Open Access Journals (Sweden)

    L. Hu

    2015-01-01

    Full Text Available Halo evolution of an Al-17.5Si alloy surface after treatment with increasing pulse numbers of a high-current pulsed electron beam (HCPEB was investigated. A halo is a ring microstructure resembling a bull’s eye. SEM results indicate that the nanocrystallization of halo induced by HCPEB treatment leads to gradual diffusion of the Si phase. Multiple pulses numbers cause the Si phase to be significantly refined and uniformly distributed. In addition, nanosilicon particles with a grain size of 30~100 nm were formed after HCPEB treatment, as shown by TEM observation. XRD results indicate that Si diffraction peaks broadened after HCPEB treatment. The microhardness tests demonstrate that the microhardness at the midpoint from the halo edge to center decreased sharply from 9770.7 MPa at 5 pulses to 2664.14 MPa at 25 pulses. The relative wear resistance of a 15-pulse sample is effectively improved by a factor of 6.5, exhibiting optimal wear resistance.

  19. WC/Co composite surface structure and nano graphite precipitate induced by high current pulsed electron beam irradiation

    Science.gov (United States)

    Hao, S. Z.; Zhang, Y.; Xu, Y.; Gey, N.; Grosdidier, T.; Dong, C.

    2013-11-01

    High current pulsed electron beam (HCPEB) irradiation was conducted on a WC-6% Co hard alloy with accelerating voltage of 27 kV and pulse duration of 2.5 μs. The surface phase structure was examined by using glancing-angle X-ray diffraction (GAXRD), scanning electron microscope (SEM) and high resolution transmission electron microscope (HRTEM) methods. The surface tribological properties were measured. It was found that after 20 pulses of HCPEB irradiation, the surface structure of WC/Co hard alloy was modified dramatically and composed of a mixture of nano-grained WC1-x, Co3W9C4, Co3W3C phases and graphite precipitate domains ˜50 nm. The friction coefficient of modified surface decreased to ˜0.38 from 0.6 of the initial state, and the wear rate reduced from 8.4 × 10-5 mm3/min to 6.3 × 10-6 mm3/min, showing a significant self-lubricating effect.

  20. A Study of Charged Current Single Charged Pion Productions on Carbon in a Few-GeV Neutrino Beam

    Energy Technology Data Exchange (ETDEWEB)

    Hiraide, Katsuki [Kyoto Univ. (Japan)

    2009-01-01

    Understanding single charged pion production via neutrino-nucleus charged current interaction in the neutrino energy region of a few GeV is essential for future neutrino oscillation experiments since this process is a dominant background for vμ → vx oscillation measurements. There are two contributions to this process: single pion production via baryonic resonance (vμN → μ-+) and coherent pion production interacting with the entire nucleus (vμA → μ-+), where N is nucleon in the nucleus and A is the nucleus. The purpose of the study presented in this thesis is a precise measurement of charged current single charged pion productions, resonant and coherent pion productions, with a good final state separation in the neutrino energy region of a few GeV. In this thesis, we focus on the study of charged current coherent pion production from muon neutrinos scattering on carbon, vμ 12C → μ-12+, in the SciBooNE experiment. This is motivated by the fact that without measuring this component first, the precise determination of resonant pion production cross section can not be achieved since the contribution of coherent pion production in the region of small muon scattering angle is not small. Furthermore, the coherent process is particularly interesting because it is deeply rooted in fundamental physics via Adler's partially conserved axial-vector current theorem. We took data from June 2007 until August 2008, in both the neutrino and antineutrino beam. In total, 2.52 x 1020 protons on target were collected. We have performed a search for charged current coherent pion production by using SciBooNE's full neutrino data set, corresponding to 0.99 x 1020 protons on target. No evidence for coherent pion production is observed. We set 90% confidence level upper limits on the cross section ratio

  1. Measurement of high-Q (2) charged current deep inelastic scattering cross sections with a longitudinally polarised positron beam at HERA

    NARCIS (Netherlands)

    Abramowicz, H.; Abt, I.; Adamczyk, L.; Adamus, M.; Aggarwal, R.; Antonelli, S.; Antonioli, P.; Antonov, A.; Arneodo, M.; Aushev, V.; Aushev, Y.; Bachynska, O.; Bamberger, A.; Barakbaev, A. N.; Barbagli, G.; Bari, G.; Barreiro, F.; Bartsch, D.; Basile, M.; Behnke, O.; Behr, J.; Behrens, U.; Bellagamba, L.; Bertolin, A.; Bhadra, S.; Bindi, M.; Blohm, C.; Bokhonov, V.; Bold, T.; Boos, E. G.; Borras, K.; Boscherini, D.; Boutle, S. K.; Brock, I.; Brownson, E.; Brugnera, R.; Bruemmer, N.; Bruni, A.; Bruni, G.; Brzozowska, B.; Bussey, P. J.; Butterworth, J. M.; Bylsma, B.; Caldwell, A.; Capua, M.; Carlin, R.; Catterall, C. D.; Chekanov, S.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cifarelli, L.; Cindolo, F.; Contin, A.; Cooper-Sarkar, A. M.; Coppola, N.; Corradi, M.; Corriveau, F.; Costa, M.; D'Agostini, G.; Dal Corso, F.; del Peso, J.; Dementiev, R. K.; De Pasquale, S.; Derrick, M.; Devenish, R. C. E.; Dobur, D.; Dolgoshein, B. A.; Dolinska, G.; Doyle, A. T.; Drugakov, V.; Durkin, L. S.; Dusini, S.; Eisenberg, Y.; Ermolov, P. F.; Eskreys, A.; Fazio, S.; Ferrando, J.; Ferrero, M. I.; Figiel, J.; Forrest, M.; Foster, B.; Fourletov, S.; Gach, G.; Galas, A.; Gallo, E.; Garfagnini, A.; Geiser, A.; Gialas, I.; Gladilin, L. K.; Gladkov, D.; Glasman, C.; Gogota, O.; Golubkov, Yu. A.; Goettlicher, P.; Grabowska-Bold, I.; Grebenyuk, J.; Gregor, I.; Grigorescu, G.; Grzelak, G.; Gwenlan, C.; Haas, T.; Hain, W.; Hamatsu, R.; Hart, J. C.; Hartmann, H.; Hartner, G.; Hilger, E.; Hochman, D.; Hori, R.; Horton, K.; Huettmann, A.; Iacobucci, G.; Ibrahim, Z. A.; Iga, Y.; Ingbir, R.; Ishitsuka, M.; Jakob, H. -P.; Januschek, F.; Jimenez, M.; Jones, T. W.; Juengst, M.; Kadenko, I.; Kahle, B.; Kamaluddin, B.; Kananov, S.; Kanno, T.; Karshon, U.; Karstens, F.; Katkov, I. I.; Kaur, M.; Kaur, P.; Keramidas, A.; Khein, L. A.; Kim, J. Y.; Kisielewska, D.; Kitamura, S.; Klanner, R.; Klein, U.; Kooijman, P.; Korol, Ie.; Korzhavina, I. A.; Kotanski, A.; Koetz, U.; Kowalski, H.; Kulinski, P.; Kuprash, O.; Kuze, M.; Lee, A.; Levchenko, B. B.; Libov, V.; Limentani, S.; Ling, T. Y.; Lisovyi, M.; Lobodzinska, E.; Lohmann, W.; Loehr, B.; Lohrmann, E.; Loizides, J. H.; Long, K. R.; Longhin, A.; Lontkovskyi, D.; Lukina, O. Yu.; Luzniak, P.; Maeda, J.; Magill, S.; Makarenko, I.; Malka, J.; Mankel, R.; Margotti, A.; Marini, G.; Mastroberardino, A.; Matsumoto, T.; Mattingly, M. C. K.; Melzer-Pellmann, I. -A.; Miglioranzi, S.; Idris, F. Mohamad; Monaco, V.; Montanari, A.; Musgrave, B.; Nagano, K.; Namsoo, T.; Nania, R.; Nicholass, D.; Nigro, A.; Ning, Y.; Noor, U.; Notz, D.; Nowak, R. J.; Nuncio-Quiroz, A. E.; Oh, B. Y.; Okazaki, N.; Oliver, K.; Olkiewicz, K.; Onishchuk, Yu.; Ota, O.; Papageorgiu, K.; Parenti, A.; Pawlak, J. M.; Pawlik, B.; Pelfer, P. G.; Pellegrino, A.; Perlanski, W.; Perrey, H.; Piotrzkowski, K.; Plucinski, P.; Pokrovskiy, N. S.; Polini, A.; Proskuryakov, A. S.; Przybycien, M.; Raval, A.; Reeder, D. D.; Reisert, B.; Ren, Z.; Repond, J.; Ri, Y. D.; Robertson, A.; Roloff, P.; Ron, E.; Rubinsky, I.; Ruspa, M.; Sacchi, R.; Salii, A.; Samson, U.; Sartorelli, G.; Savin, A. A.; Saxon, D. H.; Schioppa, M.; Schlenstedt, S.; Schleper, P.; Schmidke, W. B.; Schneekloth, U.; Schoenberg, V.; Schoerner-Sadenius, T.; Schwartz, J.; Sciulli, F.; Shcheglova, L. M.; Shehzadi, R.; Singh, I.; Skillicorn, I. O.; Slominski, W.; Smith, W. H.; Sola, V.; Solano, A.; Son, D.; Sosnovtsev, V.; Spiridonov, A.; Stadie, H.; Stanco, L.; Stern, A.; Stewart, T. P.; Stifutkin, A.; Stopa, P.; Suchkov, S.; Susinno, G.; Suszycki, L.; Sztuk-Dambietz, J.; Szuba, D.; Szuba, J.; Tapper, A. D.; Tassi, E.; Terron, J.; Theedt, T.; Tiecke, H.; Tokushuku, K.; Tomalak, O.; Tomaszewska, J.; Tsurugai, T.; Turcato, M.; Tymieniecka, T.; Uribe-Estrada, C.; Vazquez, M.; Verbytskyi, A.; Viazlo, O.; Vlasov, N. N.; Volynets, O.; Walczak, R.; Abdullah, W. A. T. Wan; Whitmore, J. J.; Whyte, J.; Wing, M.; Wlasenko, M.; Wolf, G.; Wolfe, H.; Wrona, K.; Yaguees-Molina, A. G.; Yamada, S.; Yamazaki, Y.; Yoshida, R.; Youngman, C.; Zarnecki, A. F.; Zawiejski, L.; Zenaiev, O.; Zeuner, W.; Zhautykov, B. O.; Zhmak, N.; Zichichi, A.; Zolko, M.; Zotkin, D. S.; Zulkapli, Z.

    2010-01-01

    Measurements of the cross sections for charged current deep inelastic scattering in e (+) p collisions with a longitudinally polarised positron beam are presented. The measurements are based on a data sample with an integrated luminosity of 132 pb(-1) collected with the ZEUS detector at HERA at a ce

  2. Measurement of high-Q(2) neutral current deep inelastic e(-) p scattering cross sections with a longitudinally polarised electron beam at HERA

    NARCIS (Netherlands)

    Chekanov, S.; Derrick, M.; Magill, S.; Musgrave, B.; Nicholass, D.; Repond, J.; Yoshida, R.; Mattingly, M. C. K.; Antonioli, P.; Bari, G.; Bellagamba, L.; Boscherini, D.; Bruni, A.; Bruni, G.; Cindolo, F.; Corradi, M.; Iacobucci, G.; Margotti, A.; Nania, R.; Polini, A.; Antonelli, S.; Basile, M.; Bindi, M.; Cifarelli, L.; Contin, A.; De Pasquale, S.; Sartorelli, G.; Zichichi, A.; Bartsch, D.; Brock, I.; Hartmann, H.; Hilger, E.; Jakob, H. P.; Juengst, M.; Nuncio-Quiroz, A. E.; Samson, U.; Schoenberg, V.; Shehzadi, R.; Wlasenko, M.; Brook, N. H.; Heath, G. P.; Kaur, M.; Kaur, P.; Singh, I.; Capua, M.; Fazio, S.; Mastroberardino, A.; Schioppa, M.; Susinno, G.; Tassi, E.; Kim, J. Y.; Ibrahim, Z. A.; Mohamad Idris, F.; Kamaluddin, B.; Wan Abdullah, W. A. T.; Ning, Y.; Ren, Z.; Sciulli, F.; Chwastowski, J.; Eskreys, A.; Figiel, J.; Galas, A.; Olkiewicz, K.; Pawlik, B.; Stopa, P.; Zawiejski, L.; Adamczyk, L.; Bold, T.; Grabowska-Bold, I.; Kisielewska, D.; Lukasik, J.; Przybycien, M.; Suszycki, L.; Kotanski, A.; Slominski, W.; Behnke, O.; Behrens, U.; Blohm, C.; Bonato, A.; Borras, K.; Ciesielski, R.; Coppola, N.; Fourletova, J.; Geiser, A.; Goettlicher, P.; Grebenyuk, J.; Gregor, I.; Haas, T.; Hain, W.; Huettmann, A.; Januschek, F.; Kahle, B.; Katkov, I. I.; Klein, U.; Koetz, U.; Kowalski, H.; Lisovyi, M.; Lobodzinska, E.; Loehr, B.; Mankel, R.; Melzer-Pellmann, I. -A.; Miglioranzi, S.; Montanari, A.; Namsoo, T.; Notz, D.; Parenti, A.; Rinaldi, L.; Roloff, P.; Rubinsky, I.; Schneekloth, U.; Spiridonov, A.; Szuba, D.; Szuba, J.; Theedt, T.; Ukleja, J.; Wolf, G.; Wrona, K.; Molina, A. G. Yagues; Youngman, C.; Zeuner, W.; Drugakov, V.; Lohmann, W.; Schlenstedt, S.; Barbagli, G.; Gallo, E.; Pelfer, P. G.; Bamberger, A.; Dobur, D.; Karstens, F.; Vlasov, N. N.; Bussey, P. J.; Doyle, A. T.; Dunne, W.; Forrest, M.; Rosin, M.; Saxon, D. H.; Skillicorn, I. O.; Gialas, I.; Papageorgiu, K.; Holm, U.; Klanner, R.; Lohrmann, E.; Perrey, H.; Schleper, P.; Schoerner-Sadenius, T.; Sztuk, J.; Stadie, H.; Turcato, M.; Foudas, C.; Fry, C.; Long, K. R.; Tapper, A. D.; Matsumoto, T.; Nagano, K.; Tokushuku, K.; Yamada, S.; Yamazaki, Y.; Barakbaev, A. N.; Boos, E. G.; Pokrovskiy, N. S.; Zhautykov, B. O.; Aushev, V.; Bachynska, O.; Borodin, M.; Kadenko, I.; Kozulia, A.; Libov, V.; Lontkovskyi, D.; Makarenko, I.; Sorokin, Iu.; Verbytskyi, A.; Volynets, O.; Son, D.; de Favereau, J.; Piotrzkowski, K.; Barreiro, F.; Glasman, C.; Jimenez, M.; Labarga, L.; del Peso, J.; Ron, E.; Soares, M.; Terron, J.; Uribe-Estrada, C.; Zambrana, M.; Corriveau, F.; Schwartz, J.; Walsh, R.; Tsurugai, T.; Antonov, A.; Dolgoshein, B. A.; Gladkov, D.; Sosnovtsev, V.; Stifutkin, A.; Suchkov, S.; Dementiev, R. K.; Ermolov, P. F.; Gladilin, L. K.; Golubkov, Yu. A.; Khein, L. A.; Korzhavina, I. A.; Kuzmin, V. A.; Levchenko, B. B.; Lukina, O. Yu.; Proskuryakov, A. S.; Shcheglova, L. M.; Zotkin, D. S.; Abt, I.; Caldwell, A.; Kollar, D.; Reisert, B.; Schmidke, W. B.; Grigorescu, G.; Keramidas, A.; Kooijman, P.; Pellegrino, A.; Tiecke, H.; Vazquez, M.; Bruemmer, N.; Bylsma, B.; Durkin, L. S.; Lee, A.; Ling, T. Y.; Allfrey, P. D.; Bell, M. A.; Cooper-Sarkar, A. M.; Devenish, R. C. E.; Ferrando, J.; Foster, B.; Gwenlan, C.; Horton, K.; Oliver, K.; Robertson, A.; Walczak, R.; Bertolin, A.; Dal Corso, F.; Dusini, S.; Longhin, A.; Stanco, L.; Bellan, P.; Brugnera, R.; Carlin, R.; Garfagnini, A.; Limentani, S.; Oh, B. Y.; Raval, A.; Whitmore, J. J.; Iga, Y.; D'Agostini, G.; Marini, G.; Nigro, A.; Cole, J. E.; Hart, J. C.; Abramowicz, H.; Ingbir, R.; Kananov, S.; Stern, A.; Kuze, M.; Maeda, J.; Hori, R.; Kagawa, S.; Okazaki, N.; Tawara, T.; Hamatsu, R.; Kaji, H.; Kitamura, S.; Ota, O.; Ri, Y. D.; Costa, M.; Ferrero, M. I.; Monaco, V.; Sacchi, R.; Sola, V.; Solano, A.; Arneodo, M.; Ruspa, M.; Fourletov, S.; Stewart, T. P.; Boutle, S. K.; Butterworth, J. M.; Jones, T. W.; Loizides, J. H.; Wing, M.; Brzozowska, B.; Ciborowski, J.; Grzelak, G.; Kulinski, P.; Luzniak, P.; Malka, J.; Nowak, R. J.; Pawlak, J. M.; Perlanski, W.; Tymieniecka, T.; Zarnecki, A. F.; Adamus, M.; Plucinski, P.; Ukleja, A.; Eisenberg, Y.; Hochman, D.; Karshon, U.; Brownson, E.; Reeder, D. D.; Savin, A. A.; Smith, W. H.; Wolfe, H.; Bhadra, S.; Catterall, C. D.; Hartner, G.; Menary, S.; Noor, U.; Standage, J.; Whyte, J.

    2009-01-01

    Measurements of the neutral current cross sections for deep inelastic scattering in e(-) p collisions at HERA with a longitudinally polarised electron beam are presented. The single-differential cross-sections d sigma/dQ(2), d sigma/dx and d sigma/dy and the double-differential cross sections in Q(2

  3. Measurement of high-Q(2) neutral current deep inelastic e(+) p scattering cross sections with a longitudinally polarized positron beam at HERA

    NARCIS (Netherlands)

    Abramowicz, H.; Abt, I.; Adamczyk, L.; Adamus, M.; Aggarwal, R.; Antonelli, S.; Antonioli, P.; Antonov, A.; Arneodo, M.; Aushev, V.; Aushev, Y.; Bachynska, O.; Bamberger, A.; Barakbaev, A. N.; Barbagli, G.; Bari, G.; Barreiro, F.; Bartosik, N.; Bartsch, D.; Basile, M.; Behnke, O.; Behr, J.; Behrens, U.; Bellagamba, L.; Bertolin, A.; Bhadra, S.; Bindi, M.; Blohm, C.; Bokhonov, V.; Bold, T.; Bondarenko, K.; Boos, E. G.; Borras, K.; Boscherini, D.; Brock, I.; Brownson, E.; Brugnera, R.; Bruemmer, N.; Bruni, A.; Bruni, G.; Brzozowska, B.; Bussey, P. J.; Bylsma, B.; Caldwell, A.; Capua, M.; Carlin, R.; Catterall, C. D.; Chekanov, S.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cifarelli, L.; Cindolo, F.; Contin, A.; Cooper-Sarkar, A. M.; Coppola, N.; Corradi, M.; Corriveau, F.; Costa, M.; D'Agostini, G.; Dal Corso, F.; Del Peso, J.; Dementiev, R. K.; De Pasquale, S.; Derrick, M.; Devenish, R. C. E.; Dobur, D.; Dolgoshein, B. A.; Dolinska, G.; Doyle, A. T.; Drugakov, V.; Durkin, L. S.; Dusini, S.; Eisenberg, Y.; Ermolov, P. F.; Eskreys, A.; Fazio, S.; Ferrando, J.; Ferrero, M. I.; Figiel, J.; Foster, B.; Gach, G.; Galas, A.; Gallo, E.; Garfagnini, A.; Geiser, A.; Gialas, I.; Gizhko, A.; Gladilin, L. K.; Gladkov, D.; Glasman, C.; Gogota, O.; Golubkov, Yu. A.; Goettlicher, P.; Grabowska-Bold, I.; Grebenyuk, J.; Gregor, I.; Grigorescu, G.; Grzelak, G.; Gueta, O.; Guzik, M.; Gwenlan, C.; Haas, T.; Hain, W.; Hamatsu, R.; Hart, J. C.; Hartmann, H.; Hartner, G.; Hilger, E.; Hochman, D.; Hori, R.; Huettmann, A.; Ibrahim, Z. A.; Iga, Y.; Ingbir, R.; Ishitsuka, M.; Jakob, H. -P.; Januschek, F.; Jones, T. W.; Juengst, M.; Kadenko, I.; Kahle, B.; Kananov, S.; Kanno, T.; Karshon, U.; Karstens, F.; Katkov, I. I.; Kaur, M.; Kaur, P.; Keramidas, A.; Khein, L. A.; Kim, J. Y.; Kisielewska, D.; Kitamura, S.; Klanner, R.; Klein, U.; Kondrashova, N.; Kononenko, O.; Kooijman, P.; Korol, Ie.; Korzhavina, I. A.; Kotanski, A.; Koetz, U.; Kowalski, H.; Kuprash, O.; Kuze, M.; Lee, A.; Levchenko, B. B.; Libov, V.; Limentani, S.; Ling, T. Y.; Lisovyi, M.; Lobodzinska, E.; Lohmann, W.; Loehr, B.; Lohrmann, E.; Long, K. R.; Longhin, A.; Lontkovskyi, D.; Lukina, O. Yu.; Maeda, J.; Magill, S.; Makarenko, I.; Malka, J.; Mankel, R.; Margotti, A.; Marini, G.; Mastroberardino, A.; Mattingly, M. C. K.; Melzer-Pellmann, I. -A.; Mergelmeyer, S.; Miglioranzi, S.; Idris, F. Mohamad; Monaco, V.; Montanari, A.; Mujkic, K.; Musgrave, B.; Nagano, K.; Namsoo, T.; Nania, R.; Nigro, A.; Ning, Y.; Nobe, T.; Notz, D.; Nowak, R. J.; Nuncio-Quiroz, A. E.; Oh, B. Y.; Okazaki, N.; Olkiewicz, K.; Onishchuk, Yu.; Papageorgiu, K.; Parenti, A.; Pawlak, J. M.; Pawlik, B.; Pelfer, P. G.; Pellegrino, A.; Perlanski, W.; Perrey, H.; Piotrzkowski, K.; Plucinski, P.; Pokrovskiy, N. S.; Polini, A.; Proskuryakov, A. S.; Przybycien, M.; Raval, A.; Reeder, D. D.; Reisert, B.; Ren, Z.; Repond, J.; Ri, Y. D.; Robertson, A.; Roloff, P.; Rubinsky, I.; Ruspa, M.; Sacchi, R.; Samson, U.; Sartorelli, G.; Savin, A. A.; Saxon, D. H.; Schioppa, M.; Schlenstedt, S.; Schleper, P.; Schmidke, W. B.; Schneekloth, U.; Schoenberg, V.; Schoerner-Sadenius, T.; Schwartz, J.; Sciulli, F.; Shcheglova, L. M.; Shehzadi, R.; Singh, I.; Skillicorn, I. O.; Slominski, W.; Smith, W. H.; Sola, V.; Solano, A.; Son, D.; Sosnovtsev, V.; Spiridonov, A.; Stadie, H.; Stanco, L.; Stefaniuk, N.; Stern, A.; Stewart, T. P.; Stifutkin, A.; Stopa, P.; Suchkov, S.; Susinno, G.; Suszycki, L.; Sztuk-Dambietz, J.; Szuba, D.; Szuba, J.; Tapper, A. D.; Tassi, E.; Terron, J.; Theedt, T.; Tiecke, H.; Tokushuku, K.; Tomaszewska, J.; Trusov, V.; Tsurugai, T.; Turcato, M.; Turkot, O.; Tymieniecka, T.; Vazquez, M.; Verbytskyi, A.; Viazlo, O.; Vlasov, N. N.; Walczak, R.; Abdullah, W. A. T. Wan; Whitmore, J. J.; Wichmann, K.; Wing, M.; Wlasenko, M.; Wolf, G.; Wolfe, H.; Wrona, K.; Yaguees-Molina, A. G.; Yamada, S.; Yamazaki, Y.; Yoshida, R.; Youngman, C.; Zabiegalov, O.; Zarnecki, A. F.; Zawiejski, L.; Zenaiev, O.; Zeuner, W.; Zhautykov, B. O.; Zhmak, N.; Zichichi, A.; Zolkapli, Z.; Zotkin, D. S.

    2013-01-01

    Measurements of neutral current cross sections for deep inelastic scattering in e(+)p collisions at HERA with a longitudinally polarized positron beam are presented. The single-differential cross-sections d sigma=dQ(2), d sigma=dx and d sigma=dy and the reduced cross section (sigma) over tilde are m

  4. Self-Assembled Pico-Liter Droplet Microarray for Ultrasensitive Nucleic Acid Quantification.

    Science.gov (United States)

    Yen, Tony M; Zhang, Tiantian; Chen, Ping-Wei; Ku, Ti-Hsuan; Chiu, Yu-Jui; Lian, Ian; Lo, Yu-Hwa

    2015-11-24

    Nucleic acid detection and quantification technologies have made remarkable progress in recent years. Among existing platforms, hybridization-based assays have the advantages of being amplification free, low instrument cost, and high throughput, but are generally less sensitive compared to sequencing and PCR assays. To bridge this performance gap, we developed a quantitative physical model for the hybridization-based assay to guide the experimental design, which leads to a pico-liter droplet environment with drastically enhanced performance and detection limit several order above any current microarray platform. The pico-liter droplet hybridization platform is further coupled with the on-chip enrichment technique to yield ultrahigh sensitivity both in terms of target concentration and copy number. Our physical model, taking into account of molecular transport, electrostatic intermolecular interactions, reaction kinetics, suggests that reducing liquid height and optimizing target concentration will maximize the hybridization efficiency, and both conditions can be satisfied in a highly parallel, self-assembled pico-liter droplet microarray that produces a detection limit as low as 570 copies and 50 aM. The pico-liter droplet array device is realized with a micropatterned superhydrophobic black silicon surface that allows enrichment of nucleic acid samples by position-defined evaporation. With on-chip enrichment and oil encapsulated pico-liter droplet arrays, we have demonstrated a record high sensitivity, wide dynamic range (6 orders of magnitude), and marked reduction of hybridization time from >10 h to <5 min in a highly repeatable fashion, benefiting from the physics-driven design and nanofeatures of the device. The design principle and technology can contribute to biomedical sensing and point-of-care clinical applications such as pathogen detection and cancer diagnosis and prognosis.

  5. Hacha plana de bronce de pico jano

    Directory of Open Access Journals (Sweden)

    Agustín DÍEZ CASTILLO

    2009-11-01

    Full Text Available RESUMEN: En este artículo se estudia un hacha plana hallada en la comarca de Liébana (Cantabria. Esta comarca, a los pies de los Picos de Europa, se está demostrando como una de las más fructíferas de Cantabria para el estudio de la Prehistoria Reciente, gracias a los numerosos yacimientos localizados en los últimos años.RÉSUMÉ: En cet article on étude une hache plate retrouvée dans la Liébana(Massif Cantabrique, Espagne. Il s'agit d'une hache de forme sub-rectangulaire, donc origine doit être locale. Dans la Liébana il y a beuacoup de sites néolithiques et chalcolitiques, grâce auxquels on peut étudier la néolithisation cantabrique.

  6. Dynamics of a relativistic electron beam in a high-current diode with a knife-edge cathode

    Science.gov (United States)

    Babykin, V. M.; Gordeev, A. V.; Golovin, G. T.; Korolev, V. D.; Kopchikov, A. V.; Tulupov, M. V.; Chernenko, A. S.; Shuvaev, V. Iu.

    1991-09-01

    The generation of a 130-kA electron beam with a pulse width of 60 ns is investigated experimentally and analytically. In particular, attention is given to the volt-ampere characteristics of knife-edge cathodes of different geometries, angular scatter dynamics, and beam structure. A study of the relativistic electron beam dynamics shows that diode operation in these experiments can be approximated by a formula allowing for the finite thickness of the knife-edge cathode and for plasma and ion motion in the diode gap.

  7. Hazard assessment at Teide-Pico Viejo volcanic complex (Tenerife, Canary Islands)

    Science.gov (United States)

    Marti, Joan; Sobradelo, Rosa; Felpeto, Alicia

    2010-05-01

    need to include these volcanoes in any local and regional risk-based decision-making planning for land use and emergency management, we have conducted a detailed hazard assessment of Teide-Pico Viejo. The aim of this work is to raise awareness towards the degree of threat that Teide-Pico Viejo represents for the island of Tenerife, by means of evaluating the current eruption hazard of the volcanic complex based on a statistical analysis of the time distribution of past eruptions and the spatial extent of some of their products. The analysis of past activity and the extent of some well-identified deposits are used to calculate the recurrence probabilities of eruptions of various sizes during time periods useful to assist the intermediate and long-term land-use and emergency planning. The results indicate that Teide-Pico Viejo stratovolcanoes represent a VERY HIGH threat for Tenerife and that the northern side of the island, in particular the Icod Valley, is directly exposed to most of their hazards, so making that region highly vulnerable to any new eruption from Teide-Pico Viejo.

  8. Beam Matching Study of High Current Proton Accelerator%强流质子加速器束流匹配研究

    Institute of Scientific and Technical Information of China (English)

    刘晓英; 李宏昭; 马晓燕; 傅世年

    2009-01-01

    A high current proton accelerator requires very low beam losses in order to minimize the induced radioactivity to an acceptable level. Beam matching between the different accelerator sections is one of the key points to reduce the beam losses and emittance growth. A matching design study has been performed for the beam lines between the different types of normalconducting accelerating structures. In this paper, we will present the beamline design by TRACE3D code and multiparticle simulations of the beam behavior in different matching conditions. The results show that the beam halo and emittance growth have been well controlled with the matched design of the beam lines in both transversal and longitudinal directions.%为了使感生放射性降低到可以接受的水平,强流质子加速器必须减少束流损失.不同加速段间的束流匹配是减少束流损失和发射度增长的关键之一.研究了一台常温加速结构不同段间的束流传输线的匹配设计问题.采用TRACE3-D软件以及其他多粒子模拟软件,研究了在不同匹配状态下的束流特性.结果表明,设计所采用的横向和纵向匹配手段,能够有效地控制束晕产生和束流发射度的增长.

  9. Nevo displásico (nevo atípico)

    OpenAIRE

    Rezze, Gisele Gargantini; Leon,Alexandre; Duprat, João

    2010-01-01

    O nevo atípico (displásico) é considerado um fator importante associado com o risco aumentado de desenvolvimento do melanoma cutâneo. Acredita-se que nevos atípicos sejam lesões precursoras do melanoma cutâneo. Podem estar presentes em pacientes com múltiplos nevos melanocíticos (síndrome do nevo atípico) ou isolados e em poucas quantidades em um contexto não familial. Aparecem, geralmente, na puberdade e prevalecem em indivíduos jovens. Têm predileção por áreas expostas ao sol, especialmente...

  10. Factores de riesgo asociados al embarazo ectópico

    OpenAIRE

    Jónathan Hernández Núñez; Magel Valdés Yong; Andrés Oscar Torres Chávez

    2013-01-01

    Fundamento: el embarazo ectópico se ha duplicado en la mayor parte de los países industrializados y representa una de las principales causas de muerte materna. Objetivo: identificar factores de riesgo que predisponen al embarazo ectópico.Métodos: estudio de casos y controles realizado en un universo de 132 pacientes del Municipio Habana del Este, operadas de embarazo ectópico en el Hospital Dr. Luís Díaz Soto desde el 2009 al 2011. Se escogió una muestra al azar de 66 pacientes que constituyó...

  11. Binding of the auxiliary subunit TRIP8b to HCN channels shifts the mode of action of cAMP.

    Science.gov (United States)

    Hu, Lei; Santoro, Bina; Saponaro, Andrea; Liu, Haiying; Moroni, Anna; Siegelbaum, Steven

    2013-12-01

    Hyperpolarization-activated cyclic nucleotide-regulated cation (HCN) channels generate the hyperpolarization-activated cation current Ih present in many neurons. These channels are directly regulated by the binding of cAMP, which both shifts the voltage dependence of HCN channel opening to more positive potentials and increases maximal Ih at extreme negative voltages where voltage gating is complete. Here we report that the HCN channel brain-specific auxiliary subunit TRIP8b produces opposing actions on these two effects of cAMP. In the first action, TRIP8b inhibits the effect of cAMP to shift voltage gating, decreasing both the sensitivity of the channel to cAMP (K1/2) and the efficacy of cAMP (maximal voltage shift); conversely, cAMP binding inhibits these actions of TRIP8b. These mutually antagonistic actions are well described by a cyclic allosteric mechanism in which TRIP8b binding reduces the affinity of the channel for cAMP, with the affinity of the open state for cAMP being reduced to a greater extent than the cAMP affinity of the closed state. In a second apparently independent action, TRIP8b enhances the action of cAMP to increase maximal Ih. This latter effect cannot be explained by the cyclic allosteric model but results from a previously uncharacterized action of TRIP8b to reduce maximal current through the channel in the absence of cAMP. Because the binding of cAMP also antagonizes this second effect of TRIP8b, application of cAMP produces a larger increase in maximal Ih in the presence of TRIP8b than in its absence. These findings may provide a mechanistic explanation for the wide variability in the effects of modulatory transmitters on the voltage gating and maximal amplitude of Ih reported for different neurons in the brain.

  12. Cyclic-AMP regulation of calcium-dependent K channels in an insect central neurone.

    Science.gov (United States)

    David, J A; Pitman, R M

    1996-01-26

    In the cockroach fast coxal depressor motoneurone, either the muscarinic agonist McN-A-343 or dibutyryl cAMP (Db-cAMP) induced a reduction in voltage-dependent outward current. The response to McN is due to suppression of a calcium-dependent potassium current (IK,Ca) produced secondarily to a reduction in voltage-dependent calcium current (ICa). The response to Db-cAMP was investigated in order to establish whether cAMP might mediate the response to McN. ICa was suppressed by 3-isobutyl-1-methylxanthine (IBMX) but not by Db-cAMP. The effects of IBMX were therefore unlikely to be the result of phosphodiesterase inhibition. Since caffeine also suppressed ICa, the observed effect of IBMX is probably due to release of Ca2+ from intracellular stores. IK,Ca, evoked by injection of Ca2+, was reduced by Db-cAMP or forskolin but not by McN. These results indicate that the electrical response to McN in this neurone is not mediated by changes in cAMP.

  13. New method of a "point-like" neutron source creation based on sharp focusing of high-current deuteron beam onto deuterium-saturated target for neutron tomography

    Science.gov (United States)

    Golubev, S.; Skalyga, V.; Izotov, I.; Sidorov, A.

    2017-02-01

    A possibility of a compact powerful point-like neutron source creation is discussed. Neutron yield of the source based on deuterium-deuterium (D-D) reaction is estimated at the level of 1011 s‑1 (1013 s‑1 for deuterium-tritium reaction). The fusion takes place due to bombardment of deuterium- (or tritium) loaded target by high-current focused deuterium ion beam with energy of 100 keV. The ion beam is formed by means of high-current quasi-gasdynamic ion source of a new generation based on an electron cyclotron resonance (ECR) discharge in an open magnetic trap sustained by powerful microwave radiation. The prospects of proposed generator for neutron tomography are discussed. Suggested method is compared to the point-like neutron sources based on a spark produced by powerful femtosecond laser pulses.

  14. Recombination-current suppression in GaAs p-n junctions grown on AlGaAs buffer layers by molecular-beam epitaxy

    Science.gov (United States)

    Rancour, D. P.; Melloch, M. R.; Pierret, R. F.; Lundstrom, M. S.; Klausmeier-Brown, M. E.; Kyono, C. S.

    1987-08-01

    n+pp+GaAs and n+pP+ GaAs/GaAs/Al0.3Ga0.7As mesa diodes have been fabricated from films grown by molecular-beam epitaxy. The diodes made from films employing an AlGaAs buffer layer show marked improvements (a factor of 5 reduction) in recombination current densities. Deep level transient spectroscopy measurements moreover indicate that deep level concentrations are reduced by the AlGaAs buffer.

  15. Constructing Dual Beam Optical Tweezers for Undergraduate Biophysics Research

    Science.gov (United States)

    Daudelin, Brian; West-Coates, Devon; Del'Etoile, Jon; Grotzke, Eric; Paramanathan, Thayaparan

    Optical tweezing, or trapping, is a modern physics technique which allows us to use the radiation pressure from laser beams to trap micron sized particles. Optical tweezers are commonly used in graduate level biophysics research but seldom used at the undergraduate level. Our goal is to construct a dual beam optical tweezers for future undergraduate biophysical research. Dual beam optical tweezers use two counter propagating laser beams to provide a stronger trap. In this study we discuss how the assembly of the dual beam optical tweezers is done through three main phases. The first phase was to construct a custom compressed air system to isolate the optical table from the vibrations from its surroundings so that we can measure pico-newton scale forces that are observed in biological systems. In addition, the biomaterial flow system was designed with a flow cell to trap biomolecules by combining several undergraduate semester projects. During the second phase we set up the optics to image and display the inside of the flow cell. Currently we are in the process of aligning the laser to create an effective trap and developing the software to control the data collection. This optical tweezers set up will enable us to study potential cancer drug interactions with DNA at the single molecule level and will be a powerful tool in promoting interdisciplinary research at the undergraduate level.

  16. The effect of cavity tuning on oxygen beam currents of an A-ECR type 14 GHz electron cyclotron resonance ion source.

    Science.gov (United States)

    Tarvainen, O; Orpana, J; Kronholm, R; Kalvas, T; Laulainen, J; Koivisto, H; Izotov, I; Skalyga, V; Toivanen, V

    2016-09-01

    The efficiency of the microwave-plasma coupling plays a significant role in the production of highly charged ion beams with electron cyclotron resonance ion sources (ECRISs). The coupling properties are affected by the mechanical design of the ion source plasma chamber and microwave launching system, as well as damping of the microwave electric field by the plasma. Several experiments attempting to optimize the microwave-plasma coupling characteristics by fine-tuning the frequency of the injected microwaves have been conducted with varying degrees of success. The inherent difficulty in interpretation of the frequency tuning results is that the effects of microwave coupling system and the cavity behavior of the plasma chamber cannot be separated. A preferable approach to study the effect of the cavity properties of the plasma chamber on extracted beam currents is to adjust the cavity dimensions. The results of such cavity tuning experiments conducted with the JYFL 14 GHz ECRIS are reported here. The cavity properties were adjusted by inserting a conducting tuner rod axially into the plasma chamber. The extracted beam currents of oxygen charge states O(3+)-O(7+) were recorded at various tuner positions and frequencies in the range of 14.00-14.15 GHz. It was observed that the tuner position affects the beam currents of high charge state ions up to several tens of percent. In particular, it was found that at some tuner position / frequency combinations the plasma exhibited "mode-hopping" between two operating regimes. The results improve the understanding of the role of plasma chamber cavity properties on ECRIS performances.

  17. The effect of cavity tuning on oxygen beam currents of an A-ECR type 14 GHz electron cyclotron resonance ion source

    Science.gov (United States)

    Tarvainen, O.; Orpana, J.; Kronholm, R.; Kalvas, T.; Laulainen, J.; Koivisto, H.; Izotov, I.; Skalyga, V.; Toivanen, V.

    2016-09-01

    The efficiency of the microwave-plasma coupling plays a significant role in the production of highly charged ion beams with electron cyclotron resonance ion sources (ECRISs). The coupling properties are affected by the mechanical design of the ion source plasma chamber and microwave launching system, as well as damping of the microwave electric field by the plasma. Several experiments attempting to optimize the microwave-plasma coupling characteristics by fine-tuning the frequency of the injected microwaves have been conducted with varying degrees of success. The inherent difficulty in interpretation of the frequency tuning results is that the effects of microwave coupling system and the cavity behavior of the plasma chamber cannot be separated. A preferable approach to study the effect of the cavity properties of the plasma chamber on extracted beam currents is to adjust the cavity dimensions. The results of such cavity tuning experiments conducted with the JYFL 14 GHz ECRIS are reported here. The cavity properties were adjusted by inserting a conducting tuner rod axially into the plasma chamber. The extracted beam currents of oxygen charge states O3+-O7+ were recorded at various tuner positions and frequencies in the range of 14.00-14.15 GHz. It was observed that the tuner position affects the beam currents of high charge state ions up to several tens of percent. In particular, it was found that at some tuner position / frequency combinations the plasma exhibited "mode-hopping" between two operating regimes. The results improve the understanding of the role of plasma chamber cavity properties on ECRIS performances.

  18. The effect of cavity tuning on oxygen beam currents of an A-ECR type 14 GHz electron cyclotron resonance ion source

    Energy Technology Data Exchange (ETDEWEB)

    Tarvainen, O., E-mail: olli.tarvainen@jyu.fi; Orpana, J.; Kronholm, R.; Kalvas, T.; Laulainen, J.; Koivisto, H. [Department of Physics (JYFL), University of Jyväskylä, 40500 Jyväskylä (Finland); Izotov, I.; Skalyga, V. [Institute of Applied Physics, RAS, 46 Ul’yanova St., 603950 Nizhny Novgorod (Russian Federation); Lobachevsky State University of Nizhny Novgorod (UNN), 23 Gagarina St., 603950 Nizhny Novgorod (Russian Federation); Toivanen, V. [European Organization for Nuclear Research (CERN), 1211 Geneva 23 (Switzerland)

    2016-09-15

    The efficiency of the microwave-plasma coupling plays a significant role in the production of highly charged ion beams with electron cyclotron resonance ion sources (ECRISs). The coupling properties are affected by the mechanical design of the ion source plasma chamber and microwave launching system, as well as damping of the microwave electric field by the plasma. Several experiments attempting to optimize the microwave-plasma coupling characteristics by fine-tuning the frequency of the injected microwaves have been conducted with varying degrees of success. The inherent difficulty in interpretation of the frequency tuning results is that the effects of microwave coupling system and the cavity behavior of the plasma chamber cannot be separated. A preferable approach to study the effect of the cavity properties of the plasma chamber on extracted beam currents is to adjust the cavity dimensions. The results of such cavity tuning experiments conducted with the JYFL 14 GHz ECRIS are reported here. The cavity properties were adjusted by inserting a conducting tuner rod axially into the plasma chamber. The extracted beam currents of oxygen charge states O{sup 3+}–O{sup 7+} were recorded at various tuner positions and frequencies in the range of 14.00–14.15 GHz. It was observed that the tuner position affects the beam currents of high charge state ions up to several tens of percent. In particular, it was found that at some tuner position / frequency combinations the plasma exhibited “mode-hopping” between two operating regimes. The results improve the understanding of the role of plasma chamber cavity properties on ECRIS performances.

  19. STUDY OF CYCLIC AMP IN HUMAN SEMEN

    Institute of Scientific and Technical Information of China (English)

    JIANGNing

    1989-01-01

    It had been observed that there was a close relationship between cyclic AMP and the motility, energy metabolism, capaeitation and acrosome reaction of spermatozoa. In this study a radio-immunoassay procedure for measuring cAMP concentration in sperm and

  20. Non-moving Hadamard matrix diffusers for speckle reduction in laser pico-projectors.

    Science.gov (United States)

    Thomas, Weston; Middlebrook, Christopher

    2014-12-12

    Personal electronic devices such as cell phones and tablets continue to decrease in size while the number of features and add-ons keep increasing. One particular feature of great interest is an integrated projector system. Laser pico-projectors have been considered, but the technology has not been developed enough to warrant integration. With new advancements in diode technology and MEMS devices, laser-based projection is currently being advanced for pico-projectors. A primary problem encountered when using a pico-projector is coherent interference known as speckle. Laser speckle can lead to eye irritation and headaches after prolonged viewing. Diffractive optical elements known as diffusers have been examined as a means to lower speckle contrast. This paper presents a binary diffuser known as a Hadamard matrix diffuser. Using two static in-line Hadamard diffusers eliminates the need for rotation or vibration of the diffuser for temporal averaging. Two Hadamard diffusers were fabricated and contrast values measured showing good agreement with theory and simulated values.

  1. Non-moving Hadamard matrix diffusers for speckle reduction in laser pico-projectors

    Science.gov (United States)

    Thomas, Weston; Middlebrook, Christopher

    2014-12-01

    Personal electronic devices such as cell phones and tablets continue to decrease in size while the number of features and add-ons keep increasing. One particular feature of great interest is an integrated projector system. Laser pico-projectors have been considered, but the technology has not been developed enough to warrant integration. With new advancements in diode technology and MEMS devices, laser-based projection is currently being advanced for pico-projectors. A primary problem encountered when using a pico-projector is coherent interference known as speckle. Laser speckle can lead to eye irritation and headaches after prolonged viewing. Diffractive optical elements known as diffusers have been examined as a means to lower speckle contrast. This paper presents a binary diffuser known as a Hadamard matrix diffuser. Using two static in-line Hadamard diffusers eliminates the need for rotation or vibration of the diffuser for temporal averaging. Two Hadamard diffusers were fabricated and contrast values measured showing good agreement with theory and simulated values.

  2. Generation of multi-charged high current ion beams using the SMIS 37 gas-dynamic electron cyclotron resonance (ECR) ion source

    Energy Technology Data Exchange (ETDEWEB)

    Dorf, M. A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Zorin, V. G. [Russian Academy of Sciences (RAS), Nizhny Novgorod (Russian Federation). Inst. of Applied Physics; Sidorov, A. V. [Russian Academy of Sciences (RAS), Nizhny Novgorod (Russian Federation). Inst. of Applied Physics; Bokhanov, A. F. [Russian Academy of Sciences (RAS), Nizhny Novgorod (Russian Federation). Inst. of Applied Physics; Izotov, I. V. [Russian Academy of Sciences (RAS), Nizhny Novgorod (Russian Federation). Inst. of Applied Physics; Razin, S. V. [Russian Academy of Sciences (RAS), Nizhny Novgorod (Russian Federation). Inst. of Applied Physics; Skalyga, V. A. [Russian Academy of Sciences (RAS), Nizhny Novgorod (Russian Federation). Inst. of Applied Physics

    2013-06-02

    A gas-dynamic ECR ion source (GaDIS) is distinguished by its ability to produce high current and high brightness beams of moderately charged ions. Contrary to a classical ECR ion source where the plasma confinement is determined by the slow electron scattering into an empty loss-cone, the higher density and lower electron temperature in a GaDIS plasma lead to an isotropic electron distribution with the confinement time determined by the prompt gas-dynamic flow losses. As a result, much higher ion fluxes are available, however a decrease in the confinement time of the GaDIS plasma lowers the ion charge state. The gas-dynamic ECR ion source concept has been successfully realized in the SMIS 37 experimental facility operated at the Institute of Applied Physics, Russia. The use of high-power (~100 kW) microwave (37.5 GHz) radiation provides a dense plasma (~1013 cm-3) with a relatively low electron temperature (~50- 100 eV) and allows for the generation of high current (~1 A/cm2) beams of multi-charged ions. In this work we report on the present status of the SMIS 37 ion source and discuss the advanced numerical modeling of ion beam extraction using the particle-in-cell code WARP

  3. Generation of multi-charged high current ion beams using the SMIS 37 gas-dynamic electron cyclotron resonance (ECR) ion source

    Energy Technology Data Exchange (ETDEWEB)

    Dorf, M.A., E-mail: dorf1@llnl.gov [Lawrence Livermore National Laboratory, Livermore, CA 94550 (United States); Zorin, V.G.; Sidorov, A.V.; Bokhanov, A.F.; Izotov, I.V.; Razin, S.V.; Skalyga, V.A. [Institute of Applied Physics RAS, 46 Ulyanov Street, 603950 Nizhny Novgorod (Russian Federation)

    2014-01-01

    A gas-dynamic ECR ion source (GaDIS) is distinguished by its ability to produce high current and high brightness beams of moderately charged ions. Contrary to a classical ECR ion source where the plasma confinement is determined by the slow electron scattering into an empty loss-cone, the higher density and lower electron temperature in a GaDIS plasma lead to an isotropic electron distribution with the confinement time determined by the prompt gas-dynamic flow losses. As a result, much higher ion fluxes are available; however a decrease in the confinement time of the GaDIS plasma lowers the ion charge state. The gas-dynamic ECR ion source concept has been successfully realized in the SMIS 37 experimental facility operated at the Institute of Applied Physics, Russia. The use of high-power (∼100 kW) microwave (37.5 GHz) radiation provides a dense plasma (∼10{sup 13} cm{sup −3}) with a relatively low electron temperature (∼50–100 eV) and allows for the generation of high current (∼1 A/cm{sup 2}) beams of multi-charged ions. In this work we report on the present status of the SMIS 37 ion source and discuss the advanced numerical modeling of ion beam extraction using the particle-in-cell code WARP.

  4. Measurement of Minority Charge Carrier Diffusion Length in Gallium Nitride Nanowires Using Electron Beam Induced Current (EBIC)

    Science.gov (United States)

    2009-12-01

    column consists of a thermionic emission electron gun, several magnetic lenses that control the path and focus of the electron beam and an...barrier is affected by the magnitude of the bias as illustrated in Figure 6. The reduced barrier under forward bias is the mechanism for switching in...connected to the amplifier. Figure 66 shows the expected symmetry of the EBIC signals when the contact connected to the amplifier is switched . In

  5. Waterborne Epoxy Resin Modified by AMPS

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A stable epoxy emulsion was prepared with epoxy resin (EP) as raw material, 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) as modifier and benzoyl peroxide as initiator. By criterion of yield of the copolymer AMPS-EP, water-solubility, change of the acid value and intrinsic viscosity [η] along with reaction time, the copolymerization course was deduced. It is found that during the process, AMPS takes part in both the grafting copolymerization with epoxy principal chain and the ring-opening polyaddition with epoxy group. It is also discovered that the yield of AMPS-EP and water dispersing varies with reaction time. When it reaches 1.5 h,AMPS-EP can obtain good water-solubility; but the water-solubility will go bad gradually ifit exceeds 3.5 h.( )R spectrum analysis indicates that partial epoxy group partially remains and the others create sulfonic ester.

  6. Measurement of beam currents downstream from strong electric field%强电场中的脉冲束流强度测量方法

    Institute of Scientific and Technical Information of China (English)

    柯建林; 胡永宏; 周长庚; 邱瑞; 何铁; 刘玉国

    2016-01-01

    针对强电场中电场渗透的问题,采用特殊的法拉第筒法测量脉冲束流强度:在法拉第筒入口处用栅网屏蔽强电场,并用在收集板上加正压的方式抑制二次电子。采用解析计算和数值模拟方式对栅网的形状进行了选择,在同样的栅网丝宽和透过率的前提下,通过正六边形栅网的渗透电场最弱,因此选择正六边形栅网。将设计的法拉第筒用于一台真空弧离子源的束流强度测量,获得了该离子源的束流强度波形,其峰值流强约为550 mA;利用测量结果计算了混合离子束在 Cu 收集板上的二次电子发射系数,约为2.0。%A Faraday cup used for measuring the beam currents downstream from strong electric fields was designed.The strong electric field was screened by a grid.The electrons were prohibited by the positive voltage on the collector.The shape of the grid was equilateral hexagon distributed because of its lowest saturation electric field at the same grid widths and the same grid transmission rates.The beam current of a vacuum arc ion source was measured by the designed beam current measuring device and the peak value of the beam current was about 550 mA.The secondary electron yield of the Cu collector bombarded by the hy-brid ion beams was calculated to be 2.0.

  7. The critical roles of cyclic AMP/cyclic AMP-dependent protein kinase in platelet physiology

    Institute of Scientific and Technical Information of China (English)

    Rong YAN; Suping LI; Kesheng DAI

    2009-01-01

    Platelets are the primary players in both thrombosis and hemostasis.Cyclic AMP (cAMP) and cAMP-dependent protein kinase (PKA) are important signaling molecules in the regulation of platelet function,such as adhesion,aggregation,and secretion.Elevation of intracellular cAMP,which induces the activation of PKA,results in the inhibition of platelet function.Thus,tight control of the intracellular cAMP/PKA signaling pathway has great implications for platelet-dependent hemostasis and effective cardiovascular therapy.In this review,we summarize the PKA substrates and their contributions to platelet function,especially the advancing understanding of the cAMP/PKA-dependent signaling pathway in platelet physiology.In addition,we suggest the possibility that cAMP/PKA is involved in the platelet procoagulant process and receptor ectodomain shedding.

  8. Cancellation of OpAmp virtual ground imperfections by a negative conductance applied to improve RF receiver linearity

    NARCIS (Netherlands)

    Mahrof, Dlovan H.; Klumperink, Eric A.M.; Ru, Zhiyu; Oude Alink, Mark S.; Nauta, Bram

    2014-01-01

    High linearity CMOS radio receivers often exploit linear V-I conversion at RF, followed by passive down-mixing and an OpAmp-based Transimpedance Amplifier at baseband. Due to nonlinearity and finite gain in the OpAmp, virtual ground is imperfect, inducing distortion currents. This paper proposes a n

  9. Detection and occurrence of plasmid-mediated AmpC in highly resistant gram-negative Rods

    NARCIS (Netherlands)

    E.A. Reuland (E. Ascelijn); J.P. Hays (John); D.M.C. de Jongh (Denise); E. Abdelrehim (Eman); I. Willemsen (Ina); J.A.J.W. Kluytmans (Jan); P.H.M. Savelkoul (Paul); C.M.J.E. Vandenbroucke-Grauls (Christina); N.A. Naiemi (Nashwan Al)

    2014-01-01

    textabstractObjectives: The aim of this study was to compare the current screening methods and to evaluate confirmation tests for phenotypic plasmidal AmpC (pAmpC) detection. Methods: For this evaluation we used 503 Enterobacteriaceae from 18 Dutch hospitals and 21 isolates previously confirmed to b

  10. Three Yersinia enterocolitica AmpD Homologs Participate in the Multi-Step Regulation of Chromosomal Cephalosporinase, AmpC.

    Science.gov (United States)

    Liu, Chang; Wang, Xin; Chen, Yuhuang; Hao, Huijing; Li, Xu; Liang, Junrong; Duan, Ran; Li, Chuchu; Zhang, Jing; Shao, Shihe; Jing, Huaiqi

    2016-01-01

    In many gram negative bacilli, AmpD plays a key role in both cell well-recycling pathway and β-lactamase regulation, inactivation of the ampD causes the accumulation of 1,6-anhydromuropeptides, and results in the ampC overproduction. In Yersinia enterocolitica, the regulation of ampC expression may also rely on the ampR-ampC system, the role of AmpD in this species is still unknown. In this study, three AmpD homologs (AmpD1, AmpD2, and AmpD3) have been identified in complete sequence of strain Y. enterocolitica subsp. palearctica 105.5R(r). To understand the role of three AmpD homologs, several mutant strains were constructed and analyzed where a rare ampC regulation mechanism was observed: low-effective ampD2 and ampD3 cooperate with the high-effective ampD1 in the three levels regulation of ampC expression. Enterobacteriaceae was used to be supposed to regulate ampC expression by two steps, three steps regulation was only observed in Pseudomonas aeruginosa. In this study, we first reported that Enterobacteriaceae Y. enterocolitica can also possess a three steps stepwise regulation mechanism, regulating the ampC expression precisely.

  11. Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia.

    Science.gov (United States)

    Li, Chunying; Krishnamurthy, Partha C; Penmatsa, Himabindu; Marrs, Kevin L; Wang, Xue Qing; Zaccolo, Manuela; Jalink, Kees; Li, Min; Nelson, Deborah J; Schuetz, John D; Naren, Anjaparavanda P

    2007-11-30

    Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated chloride channel localized at apical cell membranes and exists in macromolecular complexes with a variety of signaling and transporter molecules. Here, we report that the multidrug resistance protein 4 (MRP4), a cAMP transporter, functionally and physically associates with CFTR. Adenosine-stimulated CFTR-mediated chloride currents are potentiated by MRP4 inhibition, and this potentiation is directly coupled to attenuated cAMP efflux through the apical cAMP transporter. CFTR single-channel recordings and FRET-based intracellular cAMP dynamics suggest that a compartmentalized coupling of cAMP transporter and CFTR occurs via the PDZ scaffolding protein, PDZK1, forming a macromolecular complex at apical surfaces of gut epithelia. Disrupting this complex abrogates the functional coupling of cAMP transporter activity to CFTR function. Mrp4 knockout mice are more prone to CFTR-mediated secretory diarrhea. Our findings have important implications for disorders such as inflammatory bowel disease and secretory diarrhea.

  12. Spatiotemporal Coupling of cAMP Transporter to CFTR Chloride Channel Function in the Gut Epithelia

    Science.gov (United States)

    Li, Chunying; Krishnamurthy, Partha C.; Penmatsa, Himabindu; Marrs, Kevin L.; Wang, Xue Qing; Zaccolo, Manuela; Jalink, Kees; Li, Min; Nelson, Deborah J.; Schuetz, John D.; Naren, Anjaparavanda P.

    2007-01-01

    SUMMARY Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated chloride channel localized at apical cell membranes and exists in macromolecular complexes with a variety of signaling and transporter molecules. Here we report that the multidrug resistance protein 4 (MRP4), a cAMP transporter, is functionally and physically associates with CFTR. Adenosine-stimulated CFTR-mediated chloride currents are potentiated by MRP4 inhibition, and this potentiation is directly coupled to attenuated cAMP efflux through the apical cAMP transporter. CFTR single-channel recordings and FRET-based intracellular cAMP dynamics suggest that a compartmentalized coupling of cAMP transporter and CFTR occurs via the PDZ scaffolding protein, PDZK1, forming a macromolecular complex at apical surfaces of gut epithelia. Disrupting this complex abrogates the functional coupling of cAMP transporter activity to CFTR function. MRP4 knockout mice are more prone to CFTR-mediated secretory diarrhea. Our findings have important implications for disorders such as inflammatory bowel disease and secretory diarrhea. PMID:18045536

  13. Particle-in-cell simulation of electron trajectories and irradiation uniformity in an annular cathode high current pulsed electron beam source

    Science.gov (United States)

    Jiang, Wei; Wang, Langping; Zhou, Guangxue; Wang, Xiaofeng

    2017-02-01

    In order to study electron trajectories in an annular cathode high current pulsed electron beam (HCPEB) source based on carbon fiber bunches, the transmission process of electrons emitted from the annular cathode was simulated using a particle-in-cell model with Monte Carlo collisions (PIC-MCC). The simulation results show that the intense flow of the electrons emitted from the annular cathode are expanded during the transmission process, and the uniformity of the electron distribution is improved in the transportation process. The irradiation current decreases with the irradiation distance and the pressure, and increases with the negative voltage. In addition, when the irradiation distance and the cathode voltage are larger than 40 mm and -15 kV, respectively, a uniform irradiation current distribution along the circumference of the anode can be obtained. The simulation results show that good irradiation uniformity of circular components can be achieved by this annular cathode HCPEB source.

  14. Discovery of a cAMP deaminase that quenches cyclic AMP-dependent regulation.

    Science.gov (United States)

    Goble, Alissa M; Feng, Youjun; Raushel, Frank M; Cronan, John E

    2013-12-20

    An enzyme of unknown function within the amidohydrolase superfamily was discovered to catalyze the hydrolysis of the universal second messenger, cyclic-3',5'-adenosine monophosphate (cAMP). The enzyme, which we have named CadD, is encoded by the human pathogenic bacterium Leptospira interrogans. Although CadD is annotated as an adenosine deaminase, the protein specifically deaminates cAMP to cyclic-3',5'-inosine monophosphate (cIMP) with a kcat/Km of 2.7 ± 0.4 × 10(5) M(-1) s(-1) and has no activity on adenosine, adenine, or 5'-adenosine monophosphate (AMP). This is the first identification of a deaminase specific for cAMP. Expression of CadD in Escherichia coli mimics the loss of adenylate cyclase in that it blocks growth on carbon sources that require the cAMP-CRP transcriptional activator complex for expression of the cognate genes. The cIMP reaction product cannot replace cAMP as the ligand for CRP binding to DNA in vitro and cIMP is a very poor competitor of cAMP activation of CRP for DNA binding. Transcriptional analyses indicate that CadD expression represses expression of several cAMP-CRP dependent genes. CadD adds a new activity to the cAMP metabolic network and may be a useful tool in intracellular study of cAMP-dependent processes.

  15. Detailed magnetic model simulations of the H- injection chicane magnets for the CERN PS Booster Upgrade, including eddy currents and influence on beam dynamics

    CERN Document Server

    Benedetto, E; Borburgh, J; Carli, C; Martini, M; Forte, V

    2014-01-01

    The CERN PS Booster will be upgraded with an H- injection system. The chicanemagnets for the injection bump ramp-down in 5 ms and generate eddy currents in the inconel vacuum chamber which perturb the homogeneity of the magnetic field. The multipolar field components are extracted from 3D OPERA simulations and are included in the lattice model. The -beating correction is computed all along the ramp and complete tracking simulations including space-charge are performed to evaluate the impact of these perturbations and correction on beam dynamics.

  16. The cyclic AMP cascade is altered in the fragile X nervous system.

    Directory of Open Access Journals (Sweden)

    Daniel J Kelley

    Full Text Available Fragile X syndrome (FX, the most common heritable cause of mental retardation and autism, is a developmental disorder characterized by physical, cognitive, and behavioral deficits. FX results from a trinucleotide expansion mutation in the fmr1 gene that reduces levels of fragile X mental retardation protein (FMRP. Although research efforts have focused on FMRP's impact on mGluR signaling, how the loss of FMRP leads to the individual symptoms of FX is not known. Previous studies on human FX blood cells revealed alterations in the cyclic adenosine 3', 5'-monophosphate (cAMP cascade. We tested the hypothesis that cAMP signaling is altered in the FX nervous system using three different model systems. Induced levels of cAMP in platelets and in brains of fmr1 knockout mice are substantially reduced. Cyclic AMP induction is also significantly reduced in human FX neural cells. Furthermore, cAMP production is decreased in the heads of FX Drosophila and this defect can be rescued by reintroduction of the dfmr gene. Our results indicate that a robust defect in cAMP production in FX is conserved across species and suggest that cAMP metabolism may serve as a useful biomarker in the human disease population. Reduced cAMP induction has implications for the underlying causes of FX and autism spectrum disorders. Pharmacological agents known to modulate the cAMP cascade may be therapeutic in FX patients and can be tested in these models, thus supplementing current efforts centered on mGluR signaling.

  17. Intrusion Detection amp Prevention Systems - Sourcefire Snort

    Directory of Open Access Journals (Sweden)

    Rajesh Vuppala

    2015-08-01

    Full Text Available Information security is a challenging issue for all business organizations today amidst increasing cyber threats. While there are many alternative intrusion detection amp prevention systems available to choose from selecting the best solution to implement to detect amp prevent cyber-attacks is a difficult task. The best solution is of the one that gets the best reviews and suits the organizations needs amp budget. In this review paper we summarize various classes of intrusion detection and prevention systems compare features of alternative solutions and make recommendation for implementation of one as the best solution for business organization in Fiji.

  18. Tratamiento laparoscópico de la membrana duodenal

    Directory of Open Access Journals (Sweden)

    Luis Ricardo García-Vázquez

    Full Text Available La membrana duodenal congénita se presenta con mayor frecuencia en la región ampular, y se expresa clínicamente como obstrucción intestinal durante el periodo neonatal. En algunos escenarios el diagnóstico de esta condición clínica pasa inadvertida cuando dicha membrana es incompleta, como en los casos de membrana duodenal fenestrada. En consecuencia, se modifica la forma de presentación y se dificulta su diagnóstico temprano. Se cuenta con distintos accesos terapéuticos para esta enfermedad, desde los abiertos, hasta los endoscópicos y laparoscópicos. Se presenta el caso de una lactante con diagnóstico tardío de membrana duodenal fenestrada, que se trató quirúrgicamente mediante acceso laparoscópico.

  19. Biogeography and Photosynthetic Biomass of Arctic Marine Pico-Eukaroytes during Summer of the Record Sea Ice Minimum 2012.

    Science.gov (United States)

    Metfies, Katja; von Appen, Wilken-Jon; Kilias, Estelle; Nicolaus, Anja; Nöthig, Eva-Maria

    2016-01-01

    Information on recent photosynthetic biomass distribution and biogeography of Arctic marine pico-eukaryotes (0.2-3 μm) is needed to better understand consequences of environmental change for Arctic marine ecosystems. We analysed pico-eukaryote biomass and community composition in Fram Strait and large parts of the Central Arctic Ocean (Nansen Basin, Amundsen Basin) using chlorophyll a (Chl a) measurements, automated ribosomal intergenic spacer analysis (ARISA) and 454-pyrosequencing. Samples were collected during summer 2012, the year with the most recent record sea ice minimum. Chl a concentrations were highest in eastern Fram Strait and pico-plankton accounted for 60-90% of Chl a biomass during the observation period. ARISA-patterns and 454-pyrosequencing revealed that pico-eukaryote distribution is closely related to water mass distribution in the euphotic zone of the Arctic Ocean. Phaeocystaceae, Micromonas sp., Dinophyceae and Syndiniales constitute a high proportion of sequence reads, while sequence abundance of autotrophic Phaeocystaceae and mixotrophic Micromonas sp. was inversely correlated. Highest sequence abundances of Phaeocystaceae were observed in the warm Atlantic Waters in Fram Strait, while Micromonas sp. dominated the abundant biosphere in the arctic halocline. Our results are of particular interest considering existing hypotheses that environmental conditions in Nansen Basin might become more similar to the current conditions in Fram Strait. We propose that in response, biodiversity and biomass of pico-eukaryotes in Nansen Basin could resemble those currently observed in Fram Strait in the future. This would significantly alter biogeochemical cycles in a large part of the Central Arctic Ocean.

  20. Biogeography and Photosynthetic Biomass of Arctic Marine Pico-Eukaroytes during Summer of the Record Sea Ice Minimum 2012.

    Directory of Open Access Journals (Sweden)

    Katja Metfies

    Full Text Available Information on recent photosynthetic biomass distribution and biogeography of Arctic marine pico-eukaryotes (0.2-3 μm is needed to better understand consequences of environmental change for Arctic marine ecosystems. We analysed pico-eukaryote biomass and community composition in Fram Strait and large parts of the Central Arctic Ocean (Nansen Basin, Amundsen Basin using chlorophyll a (Chl a measurements, automated ribosomal intergenic spacer analysis (ARISA and 454-pyrosequencing. Samples were collected during summer 2012, the year with the most recent record sea ice minimum. Chl a concentrations were highest in eastern Fram Strait and pico-plankton accounted for 60-90% of Chl a biomass during the observation period. ARISA-patterns and 454-pyrosequencing revealed that pico-eukaryote distribution is closely related to water mass distribution in the euphotic zone of the Arctic Ocean. Phaeocystaceae, Micromonas sp., Dinophyceae and Syndiniales constitute a high proportion of sequence reads, while sequence abundance of autotrophic Phaeocystaceae and mixotrophic Micromonas sp. was inversely correlated. Highest sequence abundances of Phaeocystaceae were observed in the warm Atlantic Waters in Fram Strait, while Micromonas sp. dominated the abundant biosphere in the arctic halocline. Our results are of particular interest considering existing hypotheses that environmental conditions in Nansen Basin might become more similar to the current conditions in Fram Strait. We propose that in response, biodiversity and biomass of pico-eukaryotes in Nansen Basin could resemble those currently observed in Fram Strait in the future. This would significantly alter biogeochemical cycles in a large part of the Central Arctic Ocean.

  1. Observation of Muon Neutrino Charged Current Events in an Off-Axis Horn-Focused Neutrino Beam Using the NOvA Prototype Detector

    Energy Technology Data Exchange (ETDEWEB)

    Diaz, Enrique Arrieta [Michigan State Univ., East Lansing, MI (United States)

    2014-01-01

    The NOνA is a long base-line neutrino oscillation experiment. It will study the oscillations between muon and electron neutrinos through the Earth. NOνA consists of two detectors separated by 810 km. Each detector will measure the electron neutrino content of the neutrino (NuMI) beam. Differences between the measurements will reveal details about the oscillation channel. The NOνA collaboration built a prototype detector on the surface at Fermilab in order to develop calibration, simulation, and reconstruction tools, using real data. This 220 ton detector is 110 mrad off the NuMI beam axis. This off-axis location allows the observation of neutrino interactions with energies around 2 GeV, where neutrinos come predominantly from charged kaon decays. During the period between October 2011 and April 2012, the prototype detector collected neutrino data from 1.67 × 1020 protons on target delivered by the NuMI beam. This analysis selected a number of candidate charged current muon neutrino events from the prototype data, which is 30% lower than predicted by the NOνA Monte Carlo simulation. The analysis suggests that the discrepancy comes from an over estimation of the neutrino flux in the Monte Carlo simulation, and in particular, from neutrinos generated in charged kaon decays. The ratio of measured divided by the simulated flux of muon neutrinos coming from charged kaon decays is: 0.70+0.108 -0.094. The NOνA collaboration may use the findings of this analysis to introduce a more accurate prediction of the neutrino flux produced by the NuMI beam in future Monte Carlo simulations.

  2. An overview of current practice in external beam radiation oncology with consideration to potential benefits and challenges for nanotechnology.

    Science.gov (United States)

    King, Raymond B; McMahon, Stephen J; Hyland, Wendy B; Jain, Suneil; Butterworth, Karl T; Prise, Kevin M; Hounsell, Alan R; McGarry, Conor K

    2017-01-01

    Over the past two decades, there has been a significant evolution in the technologies and techniques employed within the radiation oncology environment. Over the same period, extensive research into the use of nanotechnology in medicine has highlighted a range of potential benefits to its incorporation into clinical radiation oncology. This short communication describes key tools and techniques that have recently been introduced into specific stages of a patient's radiotherapy pathway, including diagnosis, external beam treatment and subsequent follow-up. At each pathway stage, consideration is given towards how nanotechnology may be combined with clinical developments to further enhance their benefit, with some potential opportunities for future research also highlighted. Prospective challenges that may influence the introduction of nanotechnology into clinical radiotherapy are also discussed, indicating the need for close collaboration between academic and clinical staff to realise the full clinical benefit of this exciting technology.

  3. Trópicos tristes y paradisíacos

    Directory of Open Access Journals (Sweden)

    Vicente Francisco Torres

    2011-09-01

    Full Text Available Este artículo continúa las indagatorias del autor sobre la visión de la selva que han dado los hombres de letras en Hispanoamérica. Como un estudio de esta naturaleza no estaría completo sin la presencia de los naturalistas, que coincidieron en equiparar el trópico con el paraíso, el presente trabajo entrega una lectura de ellos y le da cita al antropólogo Claude Lévy-Strauss, quien fue una voz discordante en la visión paradisíaca del trópico.

  4. Embarazo Ectópico Cornual: Reporte de un Caso

    OpenAIRE

    Eberedson Roque Orihuela; Mariela Delgadillo Céspedes; Antonio José Pardo Novak; Karen Mariel Delgado Nuñez

    2012-01-01

    En el embarazo ectópico cornual el saco gestacional se implanta en el cuerno uterino. Son factores de riesgo: infecciones genitales, tabaquismo, cirugía abdomino-pélvica previa, embarazo ectópico previo, tratamientos de esterilidad, técnicas de reproducción, fármacos, endometriosis, edad materna y la enfermedad inflamatoria pélvica. Se diagnostica por: anamnesis clínica, exploración física, marcadores plasmáticos placentarios, ecografía transvaginal y punción saco de Douglas. En el tratamient...

  5. Noventa y cinco casos de embarazo ectópico

    OpenAIRE

    Gómez-Palacino, Jesús Alberto

    2011-01-01

    Esta es una síntesis de los casos de embarazo ectópico que se presentaron en el Instituto de Protección Materno e Infantil de Bogotá desde el año de 1949 hasta el 31 de diciembre de 1953. Nos abstendremos, porque ella le quitaría tal carácter de resumen, de hacer recapitulación de etiopatogenia, modalidades, variedades, etc., del embarazo ectópico ; además no haríamos otra cosa que repetir las descripciones de los textos, y el hecho de presentar este trabajo ante una sociedad de especialistas...

  6. A Robust Controller Structure for Pico-Satellite Applications

    DEFF Research Database (Denmark)

    Kragelund, Martin Nygaard; Green, Martin; Kristensen, Mads

    This paper describes the development of a robust controller structure for use in pico-satellite missions. The structure relies on unknown disturbance estimation and use of robust control theory to implement a system that is robust to both unmodeled disturbances and parameter uncertainties. As one...... possible application, a satellite mission with the purpose of monitoring shipping routes for oil spills has been considered. However, it is the aim of the control structure to be widely applicable and adaptable for a vide variety of pico-satellite missions. The robust control structure has been evaluated...

  7. Nuclear order in silver at pico-Kelvin temperature

    DEFF Research Database (Denmark)

    Siemensmeyer, K.; Clausen, K.N.; Lefmann, K.

    1997-01-01

    Nuclear order in silver is observed by neutron diffraction at pico-Kelvin temperatures. The structure is a type-I antiferromagnet with critical field of 100 μT. The entropy-field phase diagram was determined using the spin-dependent absorption.......Nuclear order in silver is observed by neutron diffraction at pico-Kelvin temperatures. The structure is a type-I antiferromagnet with critical field of 100 μT. The entropy-field phase diagram was determined using the spin-dependent absorption....

  8. Embarazo Ectópico Cornual: Reporte de un Caso

    OpenAIRE

    Eberedson Roque Orihuela; Mariela Delgadillo Céspedes; Antonio José Pardo Novak; Karen Mariel Delgado Nuñez

    2012-01-01

    En el embarazo ectópico cornual el saco gestacional se implanta en el cuerno uterino. Son factores de riesgo: infecciones genitales, tabaquismo, cirugía abdomino-pélvica previa, embarazo ectópico previo, tratamientos de esterilidad, técnicas de reproducción, fármacos, endometriosis, edad materna y la enfermedad inflamatoria pélvica. Se diagnostica por: anamnesis clínica, exploración física, marcadores plasmáticos placentarios, ecografía transvaginal y punción saco de Douglas. En el tratamient...

  9. Factores de riesgo asociados al embarazo ectópico

    Directory of Open Access Journals (Sweden)

    Jónathan Hernández Núñez

    2013-12-01

    Full Text Available Fundamento: el embarazo ectópico se ha duplicado en la mayor parte de los países industrializados y representa una de las principales causas de muerte materna. Objetivo: identificar factores de riesgo que predisponen al embarazo ectópico.Métodos: estudio de casos y controles realizado en un universo de 132 pacientes del Municipio Habana del Este, operadas de embarazo ectópico en el Hospital Dr. Luís Díaz Soto desde el 2009 al 2011. Se escogió una muestra al azar de 66 pacientes que constituyó el grupo estudio; se contó con otro grupo control de igual cantidad de pacientes no operadas de embarazo ectópico en dicho período. Se analizaron variables relacionadas con factores de riesgo sociodemográficos, ginecobstétricos y quirúrgicos, conducta sexual y hábito de fumar. Se empleó la media, desviación estándar, porcentaje, test de Student, estadígrafo chi cuadrado y odds ratio. Resultados: el embarazo ectópico fue más frecuente en mujeres de color de piel blanca, entre 25 y 34 años de edad; el antecedente de enfermedad inflamatoria pélvica, endometriosis, tres o más abortos provocados, así como la historia de infertilidad, embarazo ectópico previo, inicio precoz de las relaciones sexuales, múltiples compañeros sexuales y el empleo de dispositivos intrauterinos fueron factores predisponentes para el embarazo ectópico; no así la escolaridad, ocupación, paridad, apendicectomía y cirugía tubárica previa, ni tabaquismo.Conclusiones: existen múltiples factores de riesgo que predisponen al embarazo ectópico y que contribuyen al incremento de la morbimortalidad materna, muchos de los cuales son susceptibles de ser modificados desde la atención primaria de salud.

  10. Nuclear order in silver at pico-Kelvin temperature

    DEFF Research Database (Denmark)

    Siemensmeyer, K.; Clausen, K.N.; Lefmann, K.

    1997-01-01

    Nuclear order in silver is observed by neutron diffraction at pico-Kelvin temperatures. The structure is a type-I antiferromagnet with critical field of 100 mu T. The entropy-field phase diagram was determined using the spin-dependent absorption.......Nuclear order in silver is observed by neutron diffraction at pico-Kelvin temperatures. The structure is a type-I antiferromagnet with critical field of 100 mu T. The entropy-field phase diagram was determined using the spin-dependent absorption....

  11. Developement of a large proton accelerator for innovative researches; development of low energy high current beam transport system

    Energy Technology Data Exchange (ETDEWEB)

    Ko, In Soo; Namkung, Won; Cho, M. H.; Kim, K. N.; Kim, J. H.; Bae, Y. S.; Kim, Y.; Kim, K. H.; Shim, K. Y. [Pohang University of Science and Technology, Pohang (Korea)

    2001-04-01

    We have designed the beam transport system to connect the ion source and the RFQ. In this design, we have finalized the positions of solenoids and various beam diagnostic device. We have finalize the physical and mechanical designs of solenoids, and these designs are already adopted to produce the actual solenoids. We have also studied about EPICS, Experimental Physics and Industrial Control System, to control a stepper motor as a tuner of the RFQ designed for KOMACEPICS is a real time control system for a large scale system such as accelerators and tokamaks. The purpose of this thesis is to establish a test system based on the EPICS. A Sun UtraSPARC 5 workstation is used as the Operator Interface(OPI) console, and a VME chassis contained a Motorola MVME162 single board computer is used as the Input/Output Controller(IOC). A stepper motor controller is connected to the IOC via an RS-232C as a field bus. The EPICS base, extensions, and the real time OS vxWorks are installed on the workstation. The real time OS image can be downloaded to the IOC via the FTP when the test station is started. We have installed an IOC application as a device and driver support layer for the serial communication with an RS-232C on the workstation. We have designed the IOC database configuration files and a graphic user interface style OPI panel which was programmed by the MEDM. With this OPI, we can control the stepper motor using EPICS. 17 refs., 33 figs., 9 tabs. (Author)

  12. Fitoterápicos: um mercado promissor

    Directory of Open Access Journals (Sweden)

    TRAUDI KLEIN

    2010-06-01

    Full Text Available

    Observa-se na Fitoterapia uma tendência de contribuição efetiva à saúde da população. Por consequência, a padronização de fitomedicamentos é um pré-requisito para a garantia da qualidade, bem como para a constância dos efeitos terapêuticos e segurança do usuário. A validação de processo analítico deve garantir, através de evidências experimentais, que o método atenda às exigências das aplicações analíticas, assegurando a confiabilidade dos resultados. Assim, os equipamentos e materiais de laboratório devem ser devidamente calibrados e o analista qualificado. As substâncias químicas de referência devem ser certificadas por compêndios oficiais, como as Farmacopeias ou por outros códigos autorizados pela legislação vigente.Tão importante quanto o desenvolvimento e validação de uma metodologia analítica é o posterior estudo de estabilidade, a fim de garantir que o produto mantenha sua qualidade durante toda vida útil. Para a obtenção de registro de um medicamento fitoterápico dentro dos padrões requeridos pela legislação faz-se necessário, portanto, a realização de diferentes testes para validação deste medicamento de forma a garantir sua segurança no uso, eficácia na utilização e qualidade do produto. Palavras-chave: Fitomedicamentos. Validação. Saúde Publica. Padronização. ABSTRACT Phytomedicines: a promising market There is an observable trend towards phytotherapy making a recognized effective contribution to public health. Consequently, the standardization of phytomedicines is a prerequisite for quality assurance and to ensure the consistency of therapeutic effects and safety of the user. Analytical method validation should ensure, through experimental testing, that the method meets the requirements of the analytical applications, ensuring the reliability of results. Thus, the equipment and laboratory materials must be properly calibrated and the analyst

  13. Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac- and cAMP-dependent protein kinase-dependent processes

    DEFF Research Database (Denmark)

    Petersen, Rasmus Koefoed; Madsen, Lise; Pedersen, Lone Møller

    2008-01-01

    Cyclic AMP (cAMP)-dependent processes are pivotal during the early stages of adipocyte differentiation. We show that exchange protein directly activated by cAMP (Epac), which functions as a guanine nucleotide exchange factor for the Ras-like GTPases Rap1 and Rap2, was required for cAMP-dependent ......Cyclic AMP (cAMP)-dependent processes are pivotal during the early stages of adipocyte differentiation. We show that exchange protein directly activated by cAMP (Epac), which functions as a guanine nucleotide exchange factor for the Ras-like GTPases Rap1 and Rap2, was required for c......AMP-dependent stimulation of adipocyte differentiation. Epac, working via Rap, acted synergistically with cAMP-dependent protein kinase (protein kinase A [PKA]) to promote adipogenesis. The major role of PKA was to down-regulate Rho and Rho-kinase activity, rather than to enhance CREB phosphorylation. Suppression of Rho...

  14. Study and Validation of a Double Inertial Platform for a Lunar Pico-Rover

    OpenAIRE

    Jaramillo Araque, Johan Steven

    2013-01-01

    This Final Bachelor work is a study and validation of a double Inertial Measurement Unit (IMU) for a Lunar Pico-Rover. The first chapter is a review of the current market for low-cost IMUs based on Commercial off-the-shelf components. The second chapter is a study of specifications for the MultiWii SE v0.2 inertial platform, having an arduino computer with nine degrees of freedom. The third chapter is a study of specifications for the GY-80 inertial platform with also nine degrees of freedom....

  15. Experimental study of the dependence of beam current on injection magnetic field in 6.4 GHz ECR ion source

    Indian Academy of Sciences (India)

    G S Taki; P R Sarma; D K Chakraborty; R K Bhandari; P K Ray

    2006-09-01

    The ion current from an electron cyclotron resonance (ECR) heavy ion source depends on the confining axial and radial magnetic fields. Some efforts were made by earlier workers to investigate magnetic field scaling on the performance of the ECR source. In order to study the dependence of the ion current on the injection magnetic field in the 6.4 GHz ECR source, we have measured the current by varying the peak injection field and have inferred that the variation of the current is exponential up to our maximum design injection field of 7.5 kG. An attempt has been made to understand this exponential nature on the basis of ion confinement time.

  16. Measurement of high-Q{sup 2} neutral current deep inelastic e{sup +}p scattering cross sections with a longitudinally polarised positron beam at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Abramowicz, H. [Tel Aviv Univ. (Israel). School of Physics; Max Planck Institute for Physics, Munich (Germany); Abt, I. [Max Planck Institute for Physics, Munich (Germany); Adamczyk, L. [AGH-Univ. of Science and Technology, Krakow (Poland). Faculty of Physics and Applied Computer Science] [and others; Collaboration: ZEUS Collaboration

    2012-08-15

    Measurements of neutral current cross sections for deep inelastic scattering in e{sup +}p collisions at HERA with a longitudinally polarised positron beam are presented. The single-differential cross-sections d{sigma}/dQ{sup 2}, d{sigma}/dx and d{sigma}/dy and the reduced cross-section {sigma} were measured in the kinematic region Q{sup 2}>185 GeV{sup 2} and y<0.9, where Q{sup 2} is the four-momentum transfer squared, x the Bjorken scaling variable, and y the inelasticity of the interaction. The measurements were performed separately for positively and negatively polarised positron beams. The measurements are based on an integrated luminosity of 135.5 pb{sup -1} collected with the ZEUS detector in 2006 and 2007 at a centre-of-mass energy of 318 GeV. The structure functions F{sub 3} and F{sup {gamma}Z}{sub 3} were determined by combining the e{sup +}p results presented in this paper with previously published e{sup -}p neutral current results. The asymmetry parameter A{sup +} is used to demonstrate the parity violation predicted in electroweak interactions. The measurements are well described by the predictions of the Standard Model.

  17. Measurement of high-Q{sup 2} neutral current deep inelastic e{sup -}p scattering cross sections with a longitudinally polarised electron beam at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Chekanov, S.; Derrick, M.; Magill, S. [Argonne National Lab., Argonne, IL (US)] (and others)

    2008-12-15

    Measurements of the neutral current cross sections for deep inelastic scattering in e{sup -}p collisions at HERA with a longitudinally polarised electron beam are presented. The single-differential cross-sections d{sigma}/dQ{sup 2}, d{sigma}/dx and d{sigma}/dy and the double-differential cross sections in Q{sup 2} and x are measured in the kinematic region y < 0.9 and Q{sup 2} > 185GeV{sup 2} for both positively and negatively polarised electron beams and for each polarisation state separately. The measurements are based on an integrated luminosity of 169.9 pb{sup -1} taken with the ZEUS detector in 2005 and 2006 at a centre-of-mass energy of 318GeV. The structure functions xF{sub 3} and xF{sub 3}{sup {gamma}}{sup Z} are determined by combining the e{sup -}p results presented in this paper with previously measured e{sup +}p neutral current data. The asymmetry parameter A{sup -} is used to demonstrate the parity violating effects of electroweak interactions at large spacelike photon virtuality. The measurements agree well with the predictions of the Standard Model. (orig.)

  18. Nanoelectronic devices--resonant tunnelling diodes grown on InP substrates by molecular beam epitaxy with peak to valley current ratio of 17 at room temperature

    Institute of Scientific and Technical Information of China (English)

    Zhang Yang; Zeng Yi-Ping; Ma Long; Wang Bao-Qiang; Zhu Zhan-Ping; Wang Liang-Chen; Yang Fu-Hua

    2006-01-01

    This paper reports that InAs/In0.53Ga0.47As/AlAs resonant tunnelling diodes have been grown on InP substrates by molecular beam epitaxy. Peak to valley current ratio of these devices is 17 at 300K. A peak current density of 3kA/cm2 has been obtained for diodes with AlAs barriers of ten monolayers, and an In0.53Ga0.47As well of eight monolayers with four monolayers of InAs insert layer. The effects of growth interruption for smoothing potential barrier interfaces have been investigated by high resolution transmission electron microscope.

  19. S-AMP for non-linear observation models

    DEFF Research Database (Denmark)

    Cakmak, Burak; Winther, Ole; Fleury, Bernard H.

    2015-01-01

    Recently we presented the S-AMP approach, an extension of approximate message passing (AMP), to be able to handle general invariant matrix ensembles. In this contribution we extend S-AMP to non-linear observation models. We obtain generalized AMP (GAMP) as the special case when the measurement...

  20. Beam Stop for Electron Accelerator Beam Characterisation

    Science.gov (United States)

    Roach, Greg; Sharp, Vic; Tickner, James; Uher, Josef

    2009-08-01

    Electron linear accelerator applications involving the generation of hard X-rays frequently require accurate knowledge of the electron beam parameters. We developed a beam stop device which houses a tungsten Bremsstrahlung target and enables the electron beam current, energy and position to be monitored. The beam stop consisted of four plates. The first was a removable aluminium (Al) transmission plate. Then followed the tungsten target. Behind the target there were four Al quadrant plates for beam position measurement. The last plate was a thick Al back-stop block. Currents from the four quadrants and the back-stop were measured and the beam lateral position, energy and current were calculated. The beam stop device was optimised using Monte-Carlo simulation, manufactured (including custom-made electronics and software) in our laboratory and tested at the ARPANSA (Australian Radiation Protection and Nuclear Safety Agency) linear accelerator in Melbourne. The electron beam energy was determined with a precision of 60 keV at beam energies between 11 and 21 MeV and the lateral beam position was controlled with a precision of 200 mum. The relative changes of the beam current were monitored as well.

  1. Guidance, Navigation, and Control System for Maneuverable Pico-Satellites Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Pico-satellites are an emerging new class of spacecraft. Maneuverable pico-satellites require active guidance, navigation, and control (GN&C) systems to perform...

  2. Resolving Two Beams in Beam Splitters with a Beam Position Monitor

    Science.gov (United States)

    Kurennoy, Sergey

    2002-04-01

    The beam transport system for the Advanced Hydrotest Facility (AHF) anticipates multiple beam splitters. Monitoring two transversely separated beams in a common beam pipe in the splitter sections imposes certain requirements on beam diagnostics for these sections. We explore a two-beam system in a generic beam monitor and study the feasibility of resolving the transverse positions of the two beams with one diagnostics device. Effects of unequal beam currents and of finite transverse sizes of the beams are explored analytically for both the ultra relativistic case and the long-wavelength limit.

  3. An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence

    Science.gov (United States)

    Huynh, TuAnh Ngoc; Luo, Shukun; Pensinger, Daniel; Sauer, John-Demian; Tong, Liang; Woodward, Joshua J.

    2015-01-01

    The nucleotide cyclic di-3′,5′- adenosine monophosphate (c-di-AMP) was recently identified as an essential and widespread second messenger in bacterial signaling. Among c-di-AMP–producing bacteria, altered nucleotide levels result in several physiological defects and attenuated virulence. Thus, a detailed molecular understanding of c-di-AMP metabolism is of both fundamental and practical interest. Currently, c-di-AMP degradation is recognized solely among DHH-DHHA1 domain-containing phosphodiesterases. Using chemical proteomics, we identified the Listeria monocytogenes protein PgpH as a molecular target of c-di-AMP. Biochemical and structural studies revealed that the PgpH His-Asp (HD) domain bound c-di-AMP with high affinity and specifically hydrolyzed this nucleotide to 5′-pApA. PgpH hydrolysis activity was inhibited by ppGpp, indicating a cross-talk between c-di-AMP signaling and the stringent response. Genetic analyses supported coordinated regulation of c-di-AMP levels in and out of the host. Intriguingly, a L. monocytogenes mutant that lacks c-di-AMP phosphodiesterases exhibited elevated c-di-AMP levels, hyperinduced a host type-I IFN response, and was significantly attenuated for infection. Furthermore, PgpH homologs, which belong to the 7TMR-HD family, are widespread among hundreds of c-di-AMP synthesizing microorganisms. Thus, PgpH represents a broadly conserved class of c-di-AMP phosphodiesterase with possibly other physiological functions in this crucial signaling network. PMID:25583510

  4. Incident Wave Climate at the OWC Pico Plant

    DEFF Research Database (Denmark)

    Le Crom, I.; Cabrera Bermejo, H.; Pecher, Arthur

    2011-01-01

    The aim of the study is to retrieve the incident wave information that coincides with former Pico plant operation periods. The recent implementation of a directional pressure sensor for wave measurement as well as the recovery of the data gathered by a directional wave rider buoy allowed embarking...

  5. A School Called "Inclusive": Pio Pico Elementary School.

    Science.gov (United States)

    Keller, Steven; Tres-Brevig, Maria da Penha

    Pio Pico Elementary School, Santa Ana (California), is a public school that provides a rigorous academic program for every one of its low income Latino students by embracing the multifaceted offerings of the community in a spirit of equity for all, inside and outside the classroom. This qualitative study explores the complexities of Pio Pico…

  6. Experience of pico/micro hydro based power generation

    Energy Technology Data Exchange (ETDEWEB)

    Murthy, S.S. [Indian Inst. of Technology, Delhi, New Delhi (India). Dept. of Electrical Engineering

    2010-07-01

    Although India has approximately 150,000 megawatts of hydro potential, only a small portion is tapped. There is also significant untapped hydro potential in many developing countries such as Nepal, Bhutan, Vietnam, Indonesia and regions in South America and Africa. Small-scale hydroelectric power systems with capacities of up to a few megawatts are eco-friendly and sustainable. They can be classified based on unit sizes as pico (u pto 10 kilowatts), micro (10-100 kilowatts) and mini (100 kilowatts to a few megawatts) hydro systems. Mini hydro systems are always grid connected while micro can be either grid connected or off grid. Pico is always off grid. In India, there are thousands of favorable sites in this range that should be tapped for distributed power generation to electrify local communities. This need is reflected by the global emphasis on distributed power generation as well as the Government of India's policy to promote this type of power generation. A working stand alone pico-hydro power generating system has been successfully installed in 5 sites in Karnataka. The purpose of the project was to demonstrate the technical, managerial and economic feasibility of setting up small hydro projects in remote hilly areas of Karnataka, India and its positive environmental impact. The presentation discussed the site selection criteria; installed sites of pico hydro; system description; parts of the system; the electric load controller; types of electronic load controllers; and a description of the unit and control scheme. tabs., figs.

  7. Mysteries of attraction: Giovanni Pico della Mirandola, astrology and desire.

    Science.gov (United States)

    Rutkin, H Darrel

    2010-06-01

    Although in his later years Giovanni Pico della Mirandola (1463-1494) vehemently rejected astrology, he earlier used it in a variety of ways, but primarily to provide further evidence for positions to which he had arrived by other means. One such early use appears in his commentary on his friend Girolamo Benivieni's love poetry, the Canzone d'amore, of 1486-1487. In the passages discussed here, Pico presents an intensive Platonic natural philosophical analysis based on a deep astrologically informed understanding of human nature as he attempts to explain a perennial question, namely, why one person is attracted to a certain person (or people), and another to others. I will place this discussion of the mysteries of attraction and desire in historical perspective by tracing Pico's changing relationship to astrology during the course of his short but passionate life, and in historiographic perspective by revising Frances Yates's still influential views concerning Pico's contribution to Renaissance thought and his relationship with Marsilio Ficino.

  8. El cuento en Colombia. Viento de trópico

    Directory of Open Access Journals (Sweden)

    Javier Arias Ramírez

    1961-01-01

    Full Text Available No sería "Viento de Trópico", sino Cuentos Intensos, el nombre del libro que acaba de publicar José Francisco Socarrás. Hay tal dramatismo y tal densidad psicológica, propios de quien ha vivido en continuo y fatigoso indagar de la conciencia.

  9. A cAMP-independent carbohydrate-driven mechanism inhibits tnaA expression and TnaA enzyme activity in Escherichia coli.

    Science.gov (United States)

    Li, Gang; Young, Kevin D

    2014-09-01

    When Escherichia coli is grown in a medium lacking glucose or another preferred carbohydrate, the concentration of cAMP-cAMP receptor protein (cAMP-CRP) increases, and this latter complex regulates the expression of more than 180 genes. To respond rapidly to changes in carbohydrate availability, E. coli must maintain a suitable intracellular concentration of cAMP by either exporting or degrading excess cAMP. Currently, cAMP export via the TolC protein is thought to be more efficient at reducing these levels than is CpdA-mediated degradation of cAMP. Here, we compared the contributions of TolC and CpdA by measuring the expression of cAMP-regulated genes that encode tryptophanase (TnaA) and β-galactosidase. In the presence of exogenous cAMP, a tolC mutant produced intermediate levels of these enzymes, suggesting that cAMP levels were held in check by CpdA. Conversely, a cpdA mutant produced much higher amounts of these enzymes, indicating that CpdA was more efficient than TolC at reducing cAMP levels. Surprisingly, expression of the tnaA gene halted rapidly when glucose was added to cells lacking both TolC and CpdA, even though under these conditions cAMP could not be removed by either pathway and tnaA expression should have remained high. This result suggests the existence of an additional mechanism that eliminates intracellular cAMP or terminates expression of some cAMP-CRP-regulated genes. In addition, adding glucose and other carbohydrates rapidly inhibited the function of pre-formed TnaA, indicating that TnaA is regulated by a previously unknown carbohydrate-dependent post-translational mechanism.

  10. Exposure to extremely low-frequency electromagnetic fields modulates Na+ currents in rat cerebellar granule cells through increase of AA/PGE2 and EP receptor-mediated cAMP/PKA pathway.

    Directory of Open Access Journals (Sweden)

    Yan-Lin He

    Full Text Available Although the modulation of Ca(2+ channel activity by extremely low-frequency electromagnetic fields (ELF-EMF has been studied previously, few reports have addressed the effects of such fields on the activity of voltage-activated Na(+ channels (Na(v. Here, we investigated the effects of ELF-EMF on Na(v activity in rat cerebellar granule cells (GCs. Our results reveal that exposing cerebellar GCs to ELF-EMF for 10-60 min significantly increased Na(v currents (I(Na by 30-125% in a time- and intensity-dependent manner. The Na(v channel steady-state activation curve, but not the steady-state inactivation curve, was significantly shifted (by 5.2 mV towards hyperpolarization by ELF-EMF stimulation. This phenomenon is similar to the effect of intracellular application of arachidonic acid (AA and prostaglandin E(2 (PGE(2 on I(Na in cerebellar GCs. Increases in intracellular AA, PGE(2 and phosphorylated PKA levels in cerebellar GCs were observed following ELF-EMF exposure. Western blottings indicated that the Na(V 1.2 protein on the cerebellar GCs membrane was increased, the total expression levels of Na(V 1.2 protein were not affected after exposure to ELF-EMF. Cyclooxygenase inhibitors and PGE(2 receptor (EP antagonists were able to eliminate this ELF-EMF-induced increase in phosphorylated PKA and I(Na. In addition, ELF-EMF exposure significantly enhanced the activity of PLA(2 in cerebellar GCs but did not affect COX-1 or COX-2 activity. Together, these data demonstrate for the first time that neuronal I(Na is significantly increased by ELF-EMF exposure via a cPLA2 AA PGE(2 EP receptors PKA signaling pathway.

  11. Exposure to extremely low-frequency electromagnetic fields modulates Na+ currents in rat cerebellar granule cells through increase of AA/PGE2 and EP receptor-mediated cAMP/PKA pathway.

    Science.gov (United States)

    He, Yan-Lin; Liu, Dong-Dong; Fang, Yan-Jia; Zhan, Xiao-Qin; Yao, Jin-Jing; Mei, Yan-Ai

    2013-01-01

    Although the modulation of Ca(2+) channel activity by extremely low-frequency electromagnetic fields (ELF-EMF) has been studied previously, few reports have addressed the effects of such fields on the activity of voltage-activated Na(+) channels (Na(v)). Here, we investigated the effects of ELF-EMF on Na(v) activity in rat cerebellar granule cells (GCs). Our results reveal that exposing cerebellar GCs to ELF-EMF for 10-60 min significantly increased Na(v) currents (I(Na)) by 30-125% in a time- and intensity-dependent manner. The Na(v) channel steady-state activation curve, but not the steady-state inactivation curve, was significantly shifted (by 5.2 mV) towards hyperpolarization by ELF-EMF stimulation. This phenomenon is similar to the effect of intracellular application of arachidonic acid (AA) and prostaglandin E(2) (PGE(2)) on I(Na) in cerebellar GCs. Increases in intracellular AA, PGE(2) and phosphorylated PKA levels in cerebellar GCs were observed following ELF-EMF exposure. Western blottings indicated that the Na(V) 1.2 protein on the cerebellar GCs membrane was increased, the total expression levels of Na(V) 1.2 protein were not affected after exposure to ELF-EMF. Cyclooxygenase inhibitors and PGE(2) receptor (EP) antagonists were able to eliminate this ELF-EMF-induced increase in phosphorylated PKA and I(Na). In addition, ELF-EMF exposure significantly enhanced the activity of PLA(2) in cerebellar GCs but did not affect COX-1 or COX-2 activity. Together, these data demonstrate for the first time that neuronal I(Na) is significantly increased by ELF-EMF exposure via a cPLA2 AA PGE(2) EP receptors PKA signaling pathway.

  12. Software development tool for PicoBlaze multi-processor implementation

    OpenAIRE

    Claudiu Lung; Buchman Attila

    2012-01-01

    This paper presents a useful software tool for projects with multi PicoBlaze microprocessors implemented in FPGA circuits. Application presented in this paper which use for software development PicoBlaze SDK tool is an Automatic Packet Report System (APRS), with three PicoBlaze microprocessors implemented in FPGA circuit.

  13. Cyclic AMP in oocytes controls meiotic prophase I and primordial folliculogenesis in the perinatal mouse ovary.

    Science.gov (United States)

    Wang, Yijing; Teng, Zhen; Li, Ge; Mu, Xinyi; Wang, Zhengpin; Feng, Lizhao; Niu, Wanbao; Huang, Kun; Xiang, Xi; Wang, Chao; Zhang, Hua; Xia, Guoliang

    2015-01-15

    In mammalian ovaries, a fixed population of primordial follicles forms during the perinatal stage and the oocytes contained within are arrested at the dictyate stage of meiotic prophase I. In the current study, we provide evidence that the level of cyclic AMP (cAMP) in oocytes regulates oocyte meiotic prophase I and primordial folliculogenesis in the perinatal mouse ovary. Our results show that the early meiotic development of oocytes is closely correlated with increased levels of intra-oocyte cAMP. Inhibiting cAMP synthesis in fetal ovaries delayed oocyte meiotic progression and inhibited the disassembly and degradation of synaptonemal complex protein 1. In addition, inhibiting cAMP synthesis in in vitro cultured fetal ovaries prevented primordial follicle formation. Finally, using an in situ oocyte chromosome analysis approach, we found that the dictyate arrest of oocytes is essential for primordial follicle formation under physiological conditions. Taken together, these results suggest a role for cAMP in early meiotic development and primordial follicle formation in the mouse ovary. © 2015. Published by The Company of Biologists Ltd.

  14. Measurement of high-Q{sup 2} charged current deep inelastic scattering cross sections with a longitudinally polarised positron beam at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Abramowicz, H. [Tel Aviv Univ. (Israel). Faculty of Exact Sciences, School of Physics; Max-Planck-Inst., Munich (Germany); Abt, I. [Max-Planck-Inst. fuer Physik, Muenchen (Germany); Adamczyk, L. [AGH-Univ. of Science and Technology, Cracow (PL). Faculty of Physics and Applied Computer Science] (and others)

    2010-08-15

    Measurements of the cross sections for charged current deep inelastic scattering in e{sup +}p collisions with a longitudinally polarised positron beam are presented. The measurements are based on a data sample with an integrated luminosity of 132 pb{sup -1} collected with the ZEUS detector at HERA at a centre-of-mass energy of 318 GeV. The total cross section is presented at positive and negative values of the longitudinal polarisation of the positron beams. The single-differential cross sections d{sigma}/dQ{sup 2}, d{sigma}/dx and d{sigma}/dy are presented for Q{sup 2}>200 GeV{sup 2}. The reduced cross-section {sigma} is presented in the kinematic range 200

  15. Modeling and stabilization results for a charge or current-actuated active constrained layer (ACL) beam model with the electrostatic assumption

    Science.gov (United States)

    Özer, Ahmet Özkan

    2016-04-01

    An infinite dimensional model for a three-layer active constrained layer (ACL) beam model, consisting of a piezoelectric elastic layer at the top and an elastic host layer at the bottom constraining a viscoelastic layer in the middle, is obtained for clamped-free boundary conditions by using a thorough variational approach. The Rao-Nakra thin compliant layer approximation is adopted to model the sandwich structure, and the electrostatic approach (magnetic effects are ignored) is assumed for the piezoelectric layer. Instead of the voltage actuation of the piezoelectric layer, the piezoelectric layer is proposed to be activated by a charge (or current) source. We show that, the closed-loop system with all mechanical feedback is shown to be uniformly exponentially stable. Our result is the outcome of the compact perturbation argument and a unique continuation result for the spectral problem which relies on the multipliers method. Finally, the modeling methodology of the paper is generalized to the multilayer ACL beams, and the uniform exponential stabilizability result is established analogously.

  16. Measurement of high-Q{sup 2} charged current deep inelastic scattering cross sections with a longitudinally polarised positron beam at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Abramowicz, H.; Ingbir, R.; Kananov, S.; Levy, A.; Stern, A. [Tel Aviv University, Raymond and Beverly Sackler Faculty of Exact Sciences, School of Physics, Tel Aviv (Israel); Abt, I.; Caldwell, A.; Reisert, B.; Schmidke, W.B. [Max-Planck-Institut fuer Physik, Muenchen (Germany); Adamczyk, L.; Bold, T.; Gach, G.; Grabowska-Bold, I.; Kisielewska, D.; Przybycien, M.; Suszycki, L. [AGH-University of Science and Technology, Faculty of Physics and Applied Computer Science, Cracow (Poland); Adamus, M.; Plucinski, P.; Tymieniecka, T. [Institute for Nuclear Studies, Warsaw (Poland); Aggarwal, R.; Kaur, M.; Kaur, P.; Singh, I. [Panjab University, Department of Physics, Chandigarh (India); Antonelli, S.; Basile, M.; Bindi, M.; Cifarelli, L.; Contin, A.; De Pasquale, S.; Sartorelli, G.; Zichichi, A. [University Bologna (Italy); INFN Bologna, Bologna (Italy); Antonioli, P.; Bari, G.; Bellagamba, L.; Boscherini, D.; Bruni, A.; Bruni, G.; Cindolo, F.; Corradi, M.; Iacobucci, G.; Margotti, A.; Nania, R.; Polini, A. [INFN Bologna, Bologna (Italy); Antonov, A.; Dolgoshein, B.A.; Gladkov, D.; Sosnovtsev, V.; Stifutkin, A.; Suchkov, S. [Moscow Engineering Physics Institute, Moscow (Russian Federation); Arneodo, M.; Ruspa, M. [Universita del Piemonte Orientale, Novara (Italy); INFN, Torino (Italy); Aushev, V.; Aushev, Y.; Bokhonov, V.; Dolinska, G.; Gogota, O.; Kadenko, I.; Korol, I.; Kuprash, O.; Lontkovskyi, D.; Makarenko, I.; Onishchuk, Yu.; Salii, A.; Tomalak, O.; Viazlo, O.; Volynets, O.; Zenaiev, O.; Zhmak, N.; Zolko, M. [National Academy of Sciences, Institute for Nuclear Research, Kiev (Ukraine); Kiev National University, Kiev (Ukraine); Bachynska, O.; Behnke, O.; Behr, J.; Behrens, U.; Blohm, C.; Borras, K.; Bot, D.; Ciesielski, R.; Coppola, N.; Fang, S.; Geiser, A.; Goettlicher, P.; Grebenyuk, J.; Gregor, I.; Haas, T.; Hain, W.; Huettmann, A.; Januschek, F.; Kahle, B.; Katkov, I.I.; Klein, U. [Deutsches Elektronen-Synchrotron DESY, Hamburg (Germany)] (and others)

    2010-12-15

    Measurements of the cross sections for charged current deep inelastic scattering in e {sup +} p collisions with a longitudinally polarised positron beam are presented. The measurements are based on a data sample with an integrated luminosity of 132 pb{sup -1} collected with the ZEUS detector at HERA at a centre-of-mass energy of 318 GeV. The total cross section is presented at positive and negative values of the longitudinal polarisation of the positron beams. The single-differential cross-sections d{sigma}/dQ {sup 2}, d{sigma}/dx and d{sigma}/dy are presented for Q{sup 2}>200 GeV{sup 2}. The reduced cross-section {sigma} is presented in the kinematic range 200

  17. Measurements of the neutral current e{sup {+-}}p cross sections using longitudinally polarised lepton beams at HERA II

    Energy Technology Data Exchange (ETDEWEB)

    Nikiforov, A.

    2007-01-18

    This thesis presents inclusive e{sup {+-}}p single and double differential cross sections for neutral current deep inelastic scattering measured as functions of the four-momentum transfer squared Q{sup 2} and the Bjorken variable x in interactions of longitudinally polarised leptons with unpolarised protons using the H1 detector at HERA II. An overview of the phenomenology of deep inelastic scattering is given and the experimental apparatus as well as the measurement and analysis procedures are described. The analysis is based on e{sup +}p data taken in 2003-04 and e{sup -}p data taken in 2005 at a centre-of-mass energy of {radical}(s)=318 GeV, with integrated luminosities of 47.6 pb{sup -1} and 98.4 pb{sup -1} for the e{sup +}p and e{sup -}p samples, respectively. The cross sections are measured in the range of 200current interactions and to determine the structure function xF{sub 3}. The new HERA II data are combined together with previously published data from HERA I to determine the structure function xF{sub 3} with improved precision. Furthermore, this measurement is combined with the corresponding ZEUS measurement to provide the most accurate measurement of the interference structure function xF{sup {gamma}}{sup Z}{sub 3}, which is sensitive to the valence quark distributions down to low values of x. The data on polarised cross section asymmetries A{sup {+-}} are also combined with the ZEUS data. This leads to the first observation of parity violation in neutral current e{sup {+-}}p scattering at distances down to 10{sup -18} m. The data are well described by the Standard Model predictions. (orig.)

  18. Purification, characterization, and sequencing of antimicrobial peptides, Cy-AMP1, Cy-AMP2, and Cy-AMP3, from the Cycad (Cycas revoluta) seeds.

    Science.gov (United States)

    Yokoyama, Seiya; Kato, Kouji; Koba, Atsuko; Minami, Yuji; Watanabe, Keiichi; Yagi, Fumio

    2008-12-01

    Novel antimicrobial peptides (AMP), designated Cy-AMP1, Cy-AMP2, and Cy-AMP3, were purified from seeds of the cycad (Cycas revoluta) by a CM cellulofine column, ion-exchange HPLC on SP COSMOGEL, and reverse-phase HPLC. They had molecular masses of 4583.2 Da, 4568.9 Da and 9275.8 Da, respectively, by MALDI-TOF MS analysis. Half of the amino acid residues of Cy-AMP1 and Cy-AMP2 were cysteine, glycine and proline, and their sequences were similar. The sequence of Cy-AMP3 showed high homology to various lipid transfer proteins. For Cy-AMP1 and Cy-AMP2, the concentrations of peptides required for 50% inhibition (IC(50)) of the growth of plant pathogenic fungi, Gram-positive and Gram-negative bacteria were 7.0-8.9 microg/ml. The Cy-AMP3 had weak antimicrobial activity. The structural and antimicrobial characteristics of Cy-AMP1 and Cy-AMP2 indicated that they are a novel type of antimicrobial peptide belonging to a plant defensin family.

  19. An investigation of the role of the time averaged ion beam current density upon the defect densities in thin film SIMOX

    Science.gov (United States)

    Nejim, A.; Marsh, C. D.; Giles, L. F.; Hemment, P. L. F.; Li, Y.; Chater, RJ.; Kilner, J. A.; Booker, G. R.

    1994-02-01

    The effect of the time averaged ion beam current density on the material quality of thin film SIMOX has been investigated. Thin film SOI/SIMOX material has been produced by 200 keV oxygen implantation into 3 in. Fz wafers with a background temperature of 680°C. The dose range of 5 × 10 17-7 × 10 17O+/ cm2 was selected to be near the dose threshold for the formation of a continuous buried oxide after implantation and annealing which is thought to be between 5 × 10 17 and 6 × 10 17 O +/cm 2 for 200 keV [A.E. White et al., Appl. Phys. Lett. 50 (1987) 19; P.L.F. Hemment et al., Vacuum 36 (1986) 877; Y. Li et al., in: Proc. V Int. Symp. on SOI Technology and Devices (The Electrochemical Society, 1992) p. 368 [1-3

  20. Model for Electron-Beam-Induced Current Analysis of mc-Si Addressing Defect Contrast Behavior in Heavily Contaminated PV Material: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Guthrey, H.; Gorman, B.; Al-Jassim, M.

    2012-06-01

    Much work has been done to correlate electron-beam-induced current (EBIC) contrast behavior of extended defects with the character and degree of impurity decoration. However, existing models fail to account for recently observed contrast behavior of defects in heavily contaminated mc-Si PV cells. We have observed large increases in defect contrast with decreasing temperature for all electrically active defects, regardless of their initial contrast signatures at ambient temperature. This negates the usefulness of the existing models in identifying defect character and levels of impurity decoration based on the temperature dependence of the contrast behavior. By considering the interactions of transition metal impurities with the silicon lattice and extended defects, we attempt to provide an explanation for these observations. Our findings will enhance the ability of the PV community to understand and mitigate the effects of these types of defects as the adoption of increasingly lower purity feedstocks for mc-Si PV production continues.

  1. Emittance of short-pulsed high-current ion beams formed from the plasma of the electron cyclotron resonance discharge sustained by high-power millimeter-wave gyrotron radiation

    Science.gov (United States)

    Razin, S.; Zorin, V.; Izotov, I.; Sidorov, A.; Skalyga, V.

    2014-02-01

    We present experimental results on measuring the emittance of short-pulsed (≤100 μs) high-current (80-100 mA) ion beams of heavy gases (Nitrogen, Argon) formed from a dense plasma of an ECR source of multiply charged ions (MCI) with quasi-gas-dynamic mode of plasma confinement in a magnetic trap of simple mirror configuration. The discharge was created by a high-power (90 kW) pulsed radiation of a 37.5-GHz gyrotron. The normalized emittance of generated ion beams of 100 mA current was (1.2-1.3) π mm mrad (70% of ions in the beams). Comparing these results with those obtained using a cusp magnetic trap, it was concluded that the structure of the trap magnetic field lines does not exert a decisive influence on the emittance of ion beams in the gas-dynamic ECR source of MCI.

  2. Memoria y cambio en los relatos épicos africanos

    Directory of Open Access Journals (Sweden)

    Creus, Jacint

    2006-06-01

    Full Text Available The aim of this article is double. First I want to introduce to the reader the so-called «Major Genders» in African oral literature; these can be classified as «Installation Epic Poems», «Heroic Epic Poems» and «Clan-related Epic Poems.» Second, I discuss a critique of the compilation and edition methodology used up to the present, which comes down to us wrapped in an aura of «authenticity» that corresponds with neither the reality of the compiled texts nor the vitality currently displayed by African oral literature. What really matters is not so much the creation and transmission of the narratives as the authority granted by African societies and western academic circles to a clique of specialists who performs a paralyzing function on these genders. Fortunately, there are in the field other, less heeded, politically-independent specialists who encourage the creativity and vitality of the «Major Genders» by paying attention to other features.

    La pretensión de este artículo es doble: por una parte, presentar a los lectores los llamados «géneros mayores» africanos, que pueden clasificarse en «epopeyas de instalación », «epopeyas heroicas» y «epopeyas clánicas». Pero también, por otra parte, se expone la crítica a la metodología de recopilación y publicación utilizada hasta ahora, que ha tenido siempre una pretensión de «autenticidad» que no se corresponde ni con la realidad de los textos recopilados ni con la vitalidad que toda la literatura oral africana conserva actualmente. La clave para este estudio está no tanto en la creación y la transmisión de los relatos, sino en la autoridad otorgada por las sociedades africanas y por el mundo académico occidental a determinados especialistas, que ejercen una función paralizante del género épico; frente a ellos, sin embargo, existen otros especialistas, menos tenidos en cuenta, alejados de las formas políticas del poder, que estimulan la creatividad y la

  3. Role of exchange protein directly activated by cAMP (EPAC1) in breast cancer cell migration and apoptosis.

    Science.gov (United States)

    Kumar, Naveen; Gupta, Sonal; Dabral, Surbhi; Singh, Shailja; Sehrawat, Seema

    2017-02-16

    Despite the current progress in cancer research and therapy, breast cancer remains the leading cause of mortality among half a million women worldwide. Migration and invasion of cancer cells are associated with prevalent tumor metastasis as well as high mortality. Extensive studies have powerfully established the role of prototypic second messenger cAMP and its two ubiquitously expressed intracellular cAMP receptors namely the classic protein kinaseA/cAMP-dependent protein kinase (PKA) and the more recently discovered exchange protein directly activated by cAMP/cAMP-regulated guanine nucleotide exchange factor (EPAC/cAMP-GEF) in cell migration, cell cycle regulation, and cell death. Herein, we performed the analysis of the Cancer Genome Atlas (TCGA) dataset to evaluate the essential role of cAMP molecular network in breast cancer. We report that EPAC1, PKA, and AKAP9 along with other molecular partners are amplified in breast cancer patients, indicating the importance of this signaling network. To evaluate the functional role of few of these proteins, we used pharmacological modulators and analyzed their effect on cell migration and cell death in breast cancer cells. Hence, we report that inhibition of EPAC1 activity using pharmacological modulators leads to inhibition of cell migration and induces cell death. Additionally, we also observed that the inhibition of EPAC1 resulted in disruption of its association with the microtubule cytoskeleton and delocalization of AKAP9 from the centrosome as analyzed by in vitro imaging. Finally, this study suggests for the first time the mechanistic insights of mode of action of a primary cAMP-dependent sensor, Exchange protein activated by cAMP 1 (EPAC1), via its interaction with A-kinase anchoring protein 9 (AKAP9). This study provides a new cell signaling cAMP-EPAC1-AKAP9 direction to the development of additional biotherapeutics for breast cancer.

  4. MRP4 and CFTR in the regulation of cAMP and β-adrenergic contraction in cardiac myocytes.

    Science.gov (United States)

    Sellers, Zachary M; Naren, Anjaparavanda P; Xiang, Yang; Best, Philip M

    2012-04-15

    Spatiotemporal regulation of cAMP in cardiac myocytes is integral to regulating the diverse functions downstream of β-adrenergic stimulation. The activities of cAMP phosphodiesterases modulate critical and well-studied cellular processes. Recently, in epithelial and smooth muscle cells, it was found that the multi-drug resistant protein 4 (MRP4) acts as a cAMP efflux pump to regulate intracellular cAMP levels and alter effector function, including activation of the cAMP-stimulated Cl(-) channel, CFTR (cystic fibrosis transmembrane conductance regulator). In the current study we investigated the potential role of MRP4 in regulating intracellular cAMP and β-adrenergic stimulated contraction rate in cardiac myocytes. Cultured neonatal ventricular myocytes were used for all experiments. In addition to wildtype mice, β(1)-, β(2)-, and β(1)/β(2)-adrenoceptor, and CFTR knockout mice were used. MRP4 expression was probed via Western blot, intracellular cAMP was measured by fluorescence resonance energy transfer, while the functional role of MRP4 was assayed via monitoring of isoproterenol-stimulated contraction rate. We found that MRP4 is expressed in mouse neonatal ventricular myocytes. A pharmacological inhibitor of MRP4, MK571, potentiated submaximal isoproterenol-stimulated cAMP accumulation and cardiomyocyte contraction rate via β(1)-adrenoceptors. CFTR expression was critical for submaximal isoproterenol-stimulated contraction rate. Interestingly, MRP4-dependent changes in contraction rate were CFTR-dependent, however, PDE4-dependent potentiation of contraction rate was CFTR-independent. We have shown, for the first time, a role for MRP4 in the regulation of cAMP in cardiac myocytes and involvement of CFTR in β-adrenergic stimulated contraction. Together with phosphodiesterases, MRP4 must be considered when examining cAMP regulation in cardiac myocytes. Copyright © 2012 Elsevier B.V. All rights reserved.

  5. Cystic Fibrosis Gene Encodes a cAMP-Dependent Chloride Channel in Heart

    Science.gov (United States)

    Hart, Padraig; Warth, John D.; Levesque, Paul C.; Collier, Mei Lin; Geary, Yvonne; Horowitz, Burton; Hume, Joseph R.

    1996-06-01

    cAMP-dependent chloride channels in heart contribute to autonomic regulation of action potential duration and membrane potential and have been inferred to be due to cardiac expression of the epithelial cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. In this report, a cDNA from rabbit ventricle was isolated and sequenced, which encodes an exon 5 splice variant (exon 5-) of CFTR, with >90% identity to human CFTR cDNA present in epithelial cells. Expression of this cDNA in Xenopus oocytes gave rise to robust cAMP-activated chloride currents that were absent in control water-injected oocytes. Antisense oligodeoxynucleotides directed against CFTR significnatly reduced the density of cAMP-dependent chloride currents in acutely cultured myocytes, thereby establishing a direct functional link between cardiac expression of CFTR protein and an endogenous chloride channel in native cardiac myocytes.

  6. Pico gauges for minimally invasive intracellular hydrostatic pressure measurements

    DEFF Research Database (Denmark)

    Knoblauch, Jan; Mullendore, Daniel L.; Jensen, Kaare Hartvig

    2014-01-01

    in the tip of microcapillaries, which we call pico gauges. The production of pico gauges can be accomplished with standard laboratory equipment, and measurements are comparably easy to conduct. Example pressure measurements are performed on cells that are difficult or impossible to measure with other methods.......Intracellular pressure has a multitude of functions in cells surrounded by a cell wall or similar matrix in all kingdoms of life. The functions include cell growth, nastic movements, and penetration of tissue by parasites. The precise measurement of intracellular pressure in the majority of cells......, however, remains difficult or impossible due to their small size and/or sensitivity to manipulation. Here, we report on a method that allows precise measurements in basically any cell type over all ranges of pressure. It is based on the compression of nanoliter and picoliter volumes of oil entrapped...

  7. Full-scale Data Assessment in OWC Pico Plant

    Energy Technology Data Exchange (ETDEWEB)

    Brito-Melo, A.; Neumann, F. [Wave Energy Centre Lisbon (Portugal); Sarmento, A.J.N.A. [Wave Energy Centre, Lisbon (Portugal)]|[Instituto Superior Tecnico, Department of Mechanical Engineering, Lisbon (Portugal)

    2007-07-01

    After being idle for a period of several years after its first commissioning in 1999, the European OWC pilot plant on the island of Pico in the Azores has been reactivated by 2005 and initial tests have been performed since then. The refurbishment, co-ordinated by the Wave Energy Centre in Portugal, started in 2004, and was supported by National funding under a new Portuguese funding scheme for scientific pilot projects (PRIME/DEMTEC). The activities included the complete replacement of the degraded electrical equipment and refurbishments of the existing mechanical components. This paper describes the Pico plant monitoring during the full-scale demonstration from September 2005 to October 2006 and discusses the data and results obtained so far.

  8. Pico gauges for minimally invasive intracellular hydrostatic pressure measurements.

    Science.gov (United States)

    Knoblauch, Jan; Mullendore, Daniel L; Jensen, Kaare H; Knoblauch, Michael

    2014-11-01

    Intracellular pressure has a multitude of functions in cells surrounded by a cell wall or similar matrix in all kingdoms of life. The functions include cell growth, nastic movements, and penetration of tissue by parasites. The precise measurement of intracellular pressure in the majority of cells, however, remains difficult or impossible due to their small size and/or sensitivity to manipulation. Here, we report on a method that allows precise measurements in basically any cell type over all ranges of pressure. It is based on the compression of nanoliter and picoliter volumes of oil entrapped in the tip of microcapillaries, which we call pico gauges. The production of pico gauges can be accomplished with standard laboratory equipment, and measurements are comparably easy to conduct. Example pressure measurements are performed on cells that are difficult or impossible to measure with other methods.

  9. The herpetofauna of Parque Nacional Pico Bonito, Honduras

    Directory of Open Access Journals (Sweden)

    James R. McCranie

    2005-10-01

    Full Text Available Seventy-three species of amphibians and reptiles (six salamanders, 20 anurans, 20 lizards, and 27 snakes are known from Parque Nacional Pico Bonito, Honduras. The physiography, climate, vegetation, and microhabitats of the park are briefly described. Forty-four species are recorded from Lowland Moist Forest, 45 from Premontane Wet Forest, and 14 from Lower Montane Wet Forest. The primary microhabitat and relative abundance of each species are indicated and population declines are discussed.

  10. Instrumentation for the PICO deep ice coring drill

    OpenAIRE

    1994-01-01

    An electronic data collection and control system has been developed for the PICO 13.2cm deep ice coring drill. It monitors a variety of drilling parameters including inclination, depth, temperature, pressure, RPM, weight and others. It also displays this data for the drill operator and allows the operator to control speed and direction of the drill motor. The display program allows setting limits on all parameters so an alarm sounds if anything goes wrong. This instrumentation package will be...

  11. Pico hydro power for rural electrification in developing countries

    Energy Technology Data Exchange (ETDEWEB)

    Maher, P.; Smith, N.P.A. [Nottingham Trent Univ., Dept. of Electrical Engineering, Nottingham (United Kingdom); Williams, A.A. [Nottingham Trent Univ., Dept. of Mechanical and Manufacturing Engineering, Nottingham (United Kingdom)

    1998-07-01

    Pico hydro power is a renewable energy system which has the potential to provide millions of rural people world-wide with a cheap, sustainable source of electricity. The development of new, cost-reducing approaches, including local manufacture and implementation in developing countries, has increased the accessibility of this technology to large numbers of people. The new approaches are investigated and some of the present constraints to wider adoption of this technology are analysed. (Author)

  12. Cone-beam CT技术及其在口腔正畸学中的应用进展%Current advance in application of cone-beam CT in orthodontics

    Institute of Scientific and Technical Information of China (English)

    王婷; 厉松

    2011-01-01

    在正畸的诊断治疗过程中,cone-beam CT已广泛应用于口腔界的各个领域,本文旨在对cone-beamCT的原理、特点及其在口腔正畸领域中的应用进行综述,以期增加正畸医师对于Cone-beam CT的理解.

  13. Escherichia coli exports cyclic AMP via TolC.

    Science.gov (United States)

    Hantke, Klaus; Winkler, Karin; Schultz, Joachim E

    2011-03-01

    In Escherichia coli more than 180 genes are regulated by the cyclic AMP (cAMP)-cAMP receptor protein (CRP) complex. However, more than 90% of cAMP that is made by intracellular adenylyl cyclases is found in the culture medium. How is cAMP exported from E. coli? In a tolC mutant, 0.03 mM IPTG (isopropyl-β-d-thiogalactopyranoside) was sufficient to induce β-galactosidase compared to 0.1 mM IPTG in the parent strain. In a cya mutant unable to produce cAMP about 1 mM extracellular cAMP was required to induce β-galactosidase, whereas in a cya tolC mutant 0.1 mM cAMP was sufficient. When cAMP in E. coli cya was generated intracellularly by a recombinant, weakly active adenylyl cyclase from Corynebacterium glutamicum, the critical level of cAMP necessary for induction of maltose degradation was only achieved in a tolC mutant and not in the parent strain. Deletion of a putative cAMP phosphodiesterase of E. coli, CpdA, resulted in a slightly similar, yet more diffuse phenotype. The data demonstrate that export of cAMP via TolC is a most efficient way of E. coli to lower high concentrations of cAMP in the cell and maintain its sensitivity in changing metabolic environments.

  14. Dispensing nano-pico droplets of ferrofluids

    Science.gov (United States)

    Irajizad, Peyman; Farokhnia, Nazanin; Ghasemi, Hadi

    2015-11-01

    Dispensing miniature volumes of a ferrofluid is of fundamental and practical importance for diverse applications ranging from biomedical devices, optics, and self-assembly of materials. Current dispensing systems are based on microfluidics flow-focusing approaches or acoustic actuation requiring complicated structures. A simple method is presented to continuously dispense the miniature droplets from a ferrofluid reservoir. Once a jet of the ferrofluid is subjected to a constrained flux through a membrane and an inhomogeneous magnetic field, the jet experiences a curvature-driven instability and transforms to a droplet. Ferrofluid droplets in the range of 0.1-1000 nl are dispensed with tunable dispensing frequencies. A model is developed that predicts the dispensed volume of the ferrofluid droplets with an excellent agreement with the measurements.

  15. Embarazo Ectópico Cornual: Reporte de un Caso

    Directory of Open Access Journals (Sweden)

    Eberedson Roque Orihuela

    2012-06-01

    Full Text Available En el embarazo ectópico cornual el saco gestacional se implanta en el cuerno uterino. Son factores de riesgo: infecciones genitales, tabaquismo, cirugía abdomino-pélvica previa, embarazo ectópico previo, tratamientos de esterilidad, técnicas de reproducción, fármacos, endometriosis, edad materna y la enfermedad inflamatoria pélvica. Se diagnostica por: anamnesis clínica, exploración física, marcadores plasmáticos placentarios, ecografía transvaginal y punción saco de Douglas. En el tratamiento médico se recomienda administrar metotrexate, si se acompaña de hemorragia se realiza laparotomía con resección cornual o histerectomía. Les presentamos un caso clínico de una paciente de sexo femenino de 28 años, con diagnóstico de embarazo cornual de 16 semanas de gestación, con antecedentes de presentar dos abortos y un embarazo ectópico previo. Presentaba: taquicardia, taquipnea e hipotensión. Al examen físico se evidencia sangrado transvaginal. La paciente fue sometida a cirugía, donde se interrumpió la gestación y se procedió a regularizar bordes y tejido desvitalizado.

  16. Pico hydro. Reducing technical risks for rural electrification

    Energy Technology Data Exchange (ETDEWEB)

    Williams, A.A. [School of Electrical and Electronic Engineering, University of Nottingham, University Park, Nottingham NG7 2RD (United Kingdom); Simpson, R. [Renewable Energy division, EnergyAustralia, Sydney, NSW (Australia)

    2009-08-15

    Very small hydropower (pico hydro) schemes, with an output of less than 5 kW, can be a cost-effective option for the electrification of remote rural communities. Despite the fact that each hydropower site is unique, there is potential for using standardised equipment and low-cost approaches to scheme design. Relatively low equipment costs are possible, particularly if locally manufactured in a developing country, which enable costs per unit of energy output to be lower than small petrol or diesel generators, wind turbines or PV systems. Nevertheless, it is important not to compromise on technical quality of pico hydro schemes, as this may lead to poor efficiency or long periods when the scheme cannot operate, which will affect the financial success of the scheme. In the longer term, inappropriate cost reductions may lead to reduced uptake of the technology. The challenge is therefore to provide engineering designs and implementation methods that can effectively be customised for a wide range of schemes. This paper describes research and development of successful approaches that have been used to enable pico hydropower to be implemented in diverse situations around the globe. It includes an analysis of penstock pipe sizing to achieve optimum economic design. (author)

  17. pico-PLAZA, a genome database of microbial photosynthetic eukaryotes.

    Science.gov (United States)

    Vandepoele, Klaas; Van Bel, Michiel; Richard, Guilhem; Van Landeghem, Sofie; Verhelst, Bram; Moreau, Hervé; Van de Peer, Yves; Grimsley, Nigel; Piganeau, Gwenael

    2013-08-01

    With the advent of next generation genome sequencing, the number of sequenced algal genomes and transcriptomes is rapidly growing. Although a few genome portals exist to browse individual genome sequences, exploring complete genome information from multiple species for the analysis of user-defined sequences or gene lists remains a major challenge. pico-PLAZA is a web-based resource (http://bioinformatics.psb.ugent.be/pico-plaza/) for algal genomics that combines different data types with intuitive tools to explore genomic diversity, perform integrative evolutionary sequence analysis and study gene functions. Apart from homologous gene families, multiple sequence alignments, phylogenetic trees, Gene Ontology, InterPro and text-mining functional annotations, different interactive viewers are available to study genome organization using gene collinearity and synteny information. Different search functions, documentation pages, export functions and an extensive glossary are available to guide non-expert scientists. To illustrate the versatility of the platform, different case studies are presented demonstrating how pico-PLAZA can be used to functionally characterize large-scale EST/RNA-Seq data sets and to perform environmental genomics. Functional enrichments analysis of 16 Phaeodactylum tricornutum transcriptome libraries offers a molecular view on diatom adaptation to different environments of ecological relevance. Furthermore, we show how complementary genomic data sources can easily be combined to identify marker genes to study the diversity and distribution of algal species, for example in metagenomes, or to quantify intraspecific diversity from environmental strains.

  18. KamLAND-PICO Dark Mater Search Project

    Science.gov (United States)

    Fushimi, K.; Awatani, Y.; Ejiri, H.; Hazama, R.; Ikeda, H.; Imagawa, K.; Inoue, K.; Kozlov, A.; Orito, R.; Shima, T.; Sugawara, R.; Yasuda, K.

    Dark matter search project KamLAND-PICO is proposed. The first phase of the project aims to verifying the annual modulation signal which has been reported by DAMA/LIBRA. The last phase of the project aims to determining the type of interaction between WIMPs and nucleus. The thin and wide area NaI(Tl) detector PICO-LON has been developed to determine the type of WIMPs interaction. The good performance of PICO-LON detector was obtained. The energy threshold was as low as 2 keVee and the the energy resolution was as small as 25% at 60 keVee. The highly pure NaI(Tl) crystal has been developed in collaboration with the Japanese developer. The purity of U and Th chain contaminants have been reduced to the order of a few tens of ppt. It should be remarked that the concentration of 210Pb was reduced to about 60 μBq/kg. The sensitivity to spin-independent WIMPs are discussed by applying 170 modules of NaI(Tl) with the dimension of 5 inch ϕ× 5 inch.

  19. PICO: An Object-Oriented Framework for Branch and Bound

    Energy Technology Data Exchange (ETDEWEB)

    ECKSTEIN,JONATHAN; HART,WILLIAM E.; PHILLIPS,CYNTHIA A.

    2000-12-01

    This report describes the design of PICO, a C++ framework for implementing general parallel branch-and-bound algorithms. The PICO framework provides a mechanism for the efficient implementation of a wide range of branch-and-bound methods on an equally wide range of parallel computing platforms. We first discuss the basic architecture of PICO, including the application class hierarchy and the package's serial and parallel layers. We next describe the design of the serial layer, and its central notion of manipulating subproblem states. Then, we discuss the design of the parallel layer, which includes flexible processor clustering and communication rates, various load balancing mechanisms, and a non-preemptive task scheduler running on each processor. We describe the application of the package to a branch-and-bound method for mixed integer programming, along with computational results on the ASCI Red massively parallel computer. Finally we describe the application of the branch-and-bound mixed-integer programming code to a resource constrained project scheduling problem for Pantex.

  20. Structural, Optical, and Dielectric Investigations of the Relaxor PLZT 9,75/65/35 Ceramics Irradiated by High-Current Pulsed Electron Beam

    CERN Document Server

    Efimov, V V; Kalmikov, A V; Klevtsova, E A; Minashkin, V F; Novikova, N N; Sikolenko, V V; Skripnik, A V; Sternberg, A; Tiutiunnikov, S I; Yakovlev, V A

    2002-01-01

    First time comprehensive study of high-current pulsed electron irradiation effects on the structural, optical and dielectric properties of relaxor (Pb_{(1-x)}La^{x}(Zr_{0.65}Ti_{0.35})_{1-x/4}O_{3} ceramics with x=9.75% has been provided. The electron beam had the following parameters: energy E_{e}=250 keV, current density J_{e}=1000 A/cm^{2}, pulse duration tau = 300 ns, density 10^{15} electrons/cm^{2} per pulse. Infrared reflectivity spectra in the region of 100-2000 cm^{-1} were obtained in virgin, irradiated by 1500 pulses and annealed up to t=500^{circ}C ceramics. The reconstruction of perovskite ABO_{3} structure in irradiated samples has been studied by complex use of X-ray and neutron scattering and IR spectroscopy techniques revealing the changes in transverse and longitudinal phonon modes, oscillators strength and damping of modes. Radiation effects on temperature behaviour of dielectric permittivity in the region of phase transition were studied. The possible mechanisms of pulsed electron irradiat...

  1. Correlation Between Morphological Defects, Electron Beam Induced Current Imaging, and the Electrical Properties of 4H-SiC Schottky Diodes

    Energy Technology Data Exchange (ETDEWEB)

    Wang,Y.; Ali, G.; Mikhov, M.; Vaidyanathan, V.; Skromme, B.; Raghothamachar, B.; Dudley, M.

    2005-01-01

    Defects in SiC degrade the electrical properties and yield of devices made from this material. This article examines morphological defects in 4H-SiC and defects visible in electron beam-induced current (EBIC) images and their effects on the electrical characteristics of Schottky diodes. Optical Nomarski microscopy and atomic force microscopy were used to observe the morphological defects, which are classified into 26 types based on appearance alone. Forward and reverse current-voltage characteristics were used to extract barrier heights, ideality factors, and breakdown voltages. Barrier heights decrease about linearly with increasing ideality factor, which is explained by discrete patches of low barrier height within the main contact. Barrier height, ideality, and breakdown voltage all degrade with increasing device diameter, suggesting that discrete defects are responsible. Electroluminescence was observed under reverse bias from microplasmas associated with defects containing micropipes. EBIC measurements reveal several types of features corresponding to recombination centers. The density of dark spots observed by EBIC correlates strongly with ideality factor and barrier height. Most morphological defects do not affect the reverse characteristics when no micropipes are present, but lower the barrier height and worsen the ideality factor. However, certain multiple-tailed defects, irregularly shaped defects and triangular defects with 3C inclusions substantially degrade both breakdown voltage and barrier height, and account for most of the bad devices that do not contain micropipes. Micropipes in these wafers are also frequently found to be of Type II, which do not run parallel to the c axis.

  2. Electron-beam-induced current at absorber back surfaces of Cu(In,Ga)Se{sub 2} thin-film solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Kavalakkatt, J.; Abou-Ras, D., E-mail: daniel.abou-ras@helmholtz-berlin.de; Nichterwitz, M.; Caballero, R.; Rissom, T.; Unold, T.; Scheer, R.; Schock, H. W. [Helmholtz-Zentrum Berlin für Materialien und Energie, Hahn-Meitner-Platz. 1, 14109 Berlin (Germany); Haarstrich, J.; Ronning, C. [Institut für Festkörperphysik, Friedrich Schiller Universität Jena, Max-Wien-Platz 1, 07743 Jena (Germany)

    2014-01-07

    The present work reports on investigations of the influence of the microstructure on electronic properties of Cu(In,Ga)Se{sub 2} (CIGSe) thin-film solar cells. For this purpose, ZnO/CdS/CIGSe stacks of these solar cells were lifted off the Mo-coated glass substrates. The exposed CIGSe backsides of these stacks were investigated by means of electron-beam-induced current (EBIC) and cathodoluminescence (CL) measurements as well as by electron backscattered diffraction (EBSD). EBIC and CL profiles across grain boundaries (GBs), which were identified by EBSD, do not show any significant changes at Σ3 GBs. Across non-Σ3 GBs, on the other hand, the CL signals exhibit local minima with varying peak values, while by means of EBIC, decreased and also increased short-circuit current values are measured. Overall, EBIC and CL signals change across non-Σ3 GBs always differently. This complex situation was found in various CIGSe thin films with different [Ga]/([In]+[Ga]) and [Cu]/([In]+[Ga]) ratios. A part of the EBIC profiles exhibiting reduced signals across non-Σ3 GBs can be approximated by a simple model based on diffusion of generated charge carriers to the GBs.

  3. Electron-beam-induced current at absorber back surfaces of Cu(In,Ga)Se2 thin-film solar cells

    Science.gov (United States)

    Kavalakkatt, J.; Abou-Ras, D.; Haarstrich, J.; Ronning, C.; Nichterwitz, M.; Caballero, R.; Rissom, T.; Unold, T.; Scheer, R.; Schock, H. W.

    2014-01-01

    The present work reports on investigations of the influence of the microstructure on electronic properties of Cu(In,Ga)Se2 (CIGSe) thin-film solar cells. For this purpose, ZnO/CdS/CIGSe stacks of these solar cells were lifted off the Mo-coated glass substrates. The exposed CIGSe backsides of these stacks were investigated by means of electron-beam-induced current (EBIC) and cathodoluminescence (CL) measurements as well as by electron backscattered diffraction (EBSD). EBIC and CL profiles across grain boundaries (GBs), which were identified by EBSD, do not show any significant changes at Σ3 GBs. Across non-Σ3 GBs, on the other hand, the CL signals exhibit local minima with varying peak values, while by means of EBIC, decreased and also increased short-circuit current values are measured. Overall, EBIC and CL signals change across non-Σ3 GBs always differently. This complex situation was found in various CIGSe thin films with different [Ga]/([In]+[Ga]) and [Cu]/([In]+[Ga]) ratios. A part of the EBIC profiles exhibiting reduced signals across non-Σ3 GBs can be approximated by a simple model based on diffusion of generated charge carriers to the GBs.

  4. Measurement of the inclusive νμ charged current cross section on iron and hydrocarbon in the T2K on-axis neutrino beam

    Science.gov (United States)

    Abe, K.; Adam, J.; Aihara, H.; Akiri, T.; Andreopoulos, C.; Aoki, S.; Ariga, A.; Assylbekov, S.; Autiero, D.; Barbi, M.; Barker, G. J.; Barr, G.; Bass, M.; Batkiewicz, M.; Bay, F.; Berardi, V.; Berger, B. E.; Berkman, S.; Bhadra, S.; Blaszczyk, F. d. M.; Blondel, A.; Bojechko, C.; Bordoni, S.; Boyd, S. B.; Brailsford, D.; Bravar, A.; Bronner, C.; Buchanan, N.; Calland, R. G.; Caravaca Rodríguez, J.; Cartwright, S. L.; Castillo, R.; Catanesi, M. G.; Cervera, A.; Cherdack, D.; Christodoulou, G.; Clifton, A.; Coleman, J.; Coleman, S. J.; Collazuol, G.; Connolly, K.; Cremonesi, L.; Dabrowska, A.; Danko, I.; Das, R.; Davis, S.; de Perio, P.; De Rosa, G.; Dealtry, T.; Dennis, S. R.; Densham, C.; Dewhurst, D.; Di Lodovico, F.; Di Luise, S.; Drapier, O.; Duboyski, T.; Duffy, K.; Dumarchez, J.; Dytman, S.; Dziewiecki, M.; Emery-Schrenk, S.; Ereditato, A.; Escudero, L.; Finch, A. J.; Friend, M.; Fujii, Y.; Fukuda, Y.; Furmanski, A. P.; Galymov, V.; Giffin, S.; Giganti, C.; Gilje, K.; Goeldi, D.; Golan, T.; Gonin, M.; Grant, N.; Gudin, D.; Hadley, D. R.; Haesler, A.; Haigh, M. D.; Hamilton, P.; Hansen, D.; Hara, T.; Hartz, M.; Hasegawa, T.; Hastings, N. C.; Hayato, Y.; Hearty, C.; Helmer, R. L.; Hierholzer, M.; Hignight, J.; Hillairet, A.; Himmel, A.; Hiraki, T.; Hirota, S.; Holeczek, J.; Horikawa, S.; Huang, K.; Ichikawa, A. K.; Ieki, K.; Ieva, M.; Ikeda, M.; Imber, J.; Insler, J.; Irvine, T. J.; Ishida, T.; Ishii, T.; Iwai, E.; Iwamoto, K.; Iyogi, K.; Izmaylov, A.; Jacob, A.; Jamieson, B.; Johnson, R. A.; Jo, J. H.; Jonsson, P.; Jung, C. K.; Kabirnezhad, M.; Kaboth, A. C.; Kajita, T.; Kakuno, H.; Kameda, J.; Kanazawa, Y.; Karlen, D.; Karpikov, I.; Katori, T.; Kearns, E.; Khabibullin, M.; Khotjantsev, A.; Kielczewska, D.; Kikawa, T.; Kilinski, A.; Kim, J.; Kisiel, J.; Kitching, P.; Kobayashi, T.; Koch, L.; Kolaceke, A.; Konaka, A.; Kormos, L. L.; Korzenev, A.; Koseki, K.; Koshio, Y.; Kreslo, I.; Kropp, W.; Kubo, H.; Kudenko, Y.; Kurjata, R.; Kutter, T.; Lagoda, J.; Laihem, K.; Lamont, I.; Larkin, E.; Laveder, M.; Lawe, M.; Lazos, M.; Lindner, T.; Lister, C.; Litchfield, R. P.; Longhin, A.; Ludovici, L.; Magaletti, L.; Mahn, K.; Malek, M.; Manly, S.; Marino, A. D.; Marteau, J.; Martin, J. F.; Martynenko, S.; Maruyama, T.; Matveev, V.; Mavrokoridis, K.; Mazzucato, E.; McCarthy, M.; McCauley, N.; McFarland, K. S.; McGrew, C.; Metelko, C.; Mijakowski, P.; Miller, C. A.; Minamino, A.; Mineev, O.; Missert, A.; Miura, M.; Moriyama, S.; Mueller, Th. A.; Murakami, A.; Murdoch, M.; Murphy, S.; Myslik, J.; Nakadaira, T.; Nakahata, M.; Nakamura, K.; Nakayama, S.; Nakaya, T.; Nakayoshi, K.; Nielsen, C.; Nirkko, M.; Nishikawa, K.; Nishimura, Y.; O'Keeffe, H. M.; Ohta, R.; Okumura, K.; Okusawa, T.; Oryszczak, W.; Oser, S. M.; Otani, M.; Owen, R. A.; Oyama, Y.; Palladino, V.; Palomino, J. L.; Paolone, V.; Payne, D.; Perevozchikov, O.; Perkin, J. D.; Petrov, Y.; Pickard, L.; Pinzon Guerra, E. S.; Pistillo, C.; Plonski, P.; Poplawska, E.; Popov, B.; Posiadala, M.; Poutissou, J.-M.; Poutissou, R.; Przewlocki, P.; Quilain, B.; Radicioni, E.; Ratoff, P. N.; Ravonel, M.; Rayner, M. A. M.; Redij, A.; Reeves, M.; Reinherz-Aronis, E.; Retiere, F.; Rodrigues, P. A.; Rojas, P.; Rondio, E.; Roth, S.; Rubbia, A.; Ruterbories, D.; Sacco, R.; Sakashita, K.; Sánchez, F.; Sato, F.; Scantamburlo, E.; Scholberg, K.; Schoppmann, S.; Schwehr, J.; Scott, M.; Seiya, Y.; Sekiguchi, T.; Sekiya, H.; Sgalaberna, D.; Shiozawa, M.; Short, S.; Shustrov, Y.; Sinclair, P.; Smith, B.; Smy, M.; Sobczyk, J. T.; Sobel, H.; Sorel, M.; Southwell, L.; Stamoulis, P.; Steinmann, J.; Still, B.; Suda, Y.; Suzuki, A.; Suzuki, K.; Suzuki, S. Y.; Suzuki, Y.; Szeglowski, T.; Tacik, R.; Tada, M.; Takahashi, S.; Takeda, A.; Takeuchi, Y.; Tanaka, H. K.; Tanaka, H. A.; Tanaka, M. M.; Terhorst, D.; Terri, R.; Thompson, L. F.; Thorley, A.; Tobayama, S.; Toki, W.; Tomura, T.; Totsuka, Y.; Touramanis, C.; Tsukamoto, T.; Tzanov, M.; Uchida, Y.; Vacheret, A.; Vagins, M.; Vasseur, G.; Wachala, T.; Waldron, A. V.; Walter, C. W.; Wark, D.; Wascko, M. O.; Weber, A.; Wendell, R.; Wilkes, R. J.; Wilking, M. J.; Wilkinson, C.; Williamson, Z.; Wilson, J. R.; Wilson, R. J.; Wongjirad, T.; Yamada, Y.; Yamamoto, K.; Yanagisawa, C.; Yano, T.; Yen, S.; Yershov, N.; Yokoyama, M.; Yuan, T.; Yu, M.; Zalewska, A.; Zalipska, J.; Zambelli, L.; Zaremba, K.; Ziembicki, M.; Zimmerman, E. D.; Zito, M.; Żmuda, J.; T2K Collaboration

    2014-09-01

    We report a measurement of the νμ inclusive charged current cross sections on iron and hydrocarbon in the Tokai-to-Kamioka (T2K) on-axis neutrino beam. The measured inclusive charged current cross sections on iron and hydrocarbon averaged over the T2K on-axis flux with a mean neutrino energy of 1.51 GeV are (1.444±0.002(stat)-0.157+0.189(syst))×10-38 cm2/nucleon and (1.379±0.009(stat)-0.147+0.178(syst))×10-38 cm2/nucleon, respectively, and their cross-section ratio is 1.047±0.007(stat)±0.035(syst). These results agree well with the predictions of the neutrino interaction model, and thus we checked the correct treatment of the nuclear effect for iron and hydrocarbon targets in the model within the measurement precisions.

  5. Isothermal oxidation behaviour of thermal barrier coatings with CoCrAlY bond coat irradiated by high-current pulsed electron beam

    Energy Technology Data Exchange (ETDEWEB)

    Cai, Jie [School of Materials Science and Engineering, Jiangsu University, Zhenjiang 212013 (China); Guan, Qingfeng, E-mail: guanqf@mail.ujs.edu.cn [School of Materials Science and Engineering, Jiangsu University, Zhenjiang 212013 (China); Hou, Xiuli [School of Materials Science and Engineering, Jiangsu University, Zhenjiang 212013 (China); Wang, Zhiping; Su, Jingxin; Han, Zhiyong [College of Science, Civil Aviation University of China, Tianjin 300300 (China)

    2014-10-30

    Highlights: • The original coarse surface was re-melted by pulsed electron beam irradiation. • Very fine grains were homogeneously dispersed on the irradiated coat surface. • A compact Al{sub 2}O{sub 3} scale was formed in irradiated TBCs at the onset of oxidation. • The selective oxidation of Al element avoided the formation of other oxides. • The irradiated coating has a much higher oxidation resistance. - Abstract: Thermal sprayed CoCrAlY bond coat irradiated by high-current pulsed electron beam (HCPEB) and thermal barrier coatings (TBCs) prepared with the irradiated bond coat and the ceramic top coat were investigated. The high temperature oxidation resistance of these specimens was tested at 1050 °C in air. Microstructure observations revealed that the original coarse surface of the as-sprayed bond coat was significantly changed as the interconnected bulged nodules with a compact appearance after HCPEB irradiation. Abundant Y-rich alumina particulates and very fine grains were dispersed on the irradiated surface. After high temperature oxidation test, the thermally grown oxide (TGO) in the initial TBCs grew rapidly and was comprised of two distinct layers: a large percentage of mixed oxides in the outer layer and a relatively small portion of Al{sub 2}O{sub 3} in the inner layer. Severe local internal oxidation and extensive cracks in the TGO layer were discovered as well. Comparatively, the irradiated TBCs exhibited thinner TGO layer, slower TGO growth rate, and homogeneous TGO composition (primarily consisting of Al{sub 2}O{sub 3}). The results indicate that TBCs with the irradiated bond coat have a much higher oxidation resistance.

  6. Reduction of extended-spectrum-β-lactamase- and AmpC-β-lactamase-producing Escherichia coli through processing in two broiler chicken slaughterhouses

    NARCIS (Netherlands)

    Pacholewicz, Ewa; Liakopoulos, Apostolos; Swart, Arno; Gortemaker, Betty; Dierikx, Cindy; Havelaar, Arie; Schmitt, Heike

    2015-01-01

    Whilst broilers are recognised as a reservoir of extended-spectrum-β-lactamase (ESBL)- and AmpC-β-lactamase (AmpC)-producing Escherichia coli, there is currently limited knowledge on the effect of slaughtering on its concentrations on poultry meat. The aim of this study was to establish the

  7. Reduction of extended-spectrum-β-lactamase- and AmpC-β-lactamase-producing Escherichia coli through processing in two broiler chicken slaughterhouses

    NARCIS (Netherlands)

    Pacholewicz, Ewa; Liakopoulos, Apostolos; Swart, Arno; Gortemaker, Betty; Dierikx, Cindy; Havelaar, Arie; Schmitt, Heike

    2015-01-01

    Whilst broilers are recognised as a reservoir of extended-spectrum-β-lactamase (ESBL)- and AmpC-β-lactamase (AmpC)-producing Escherichia coli, there is currently limited knowledge on the effect of slaughtering on its concentrations on poultry meat. The aim of this study was to establish the

  8. Reduction of extended-spectrum-β-lactamase- and AmpC-β-lactamase-producing Escherichia coli through processing in two broiler chicken slaughterhouses

    NARCIS (Netherlands)

    Pacholewicz, Ewa; Liakopoulos, Apostolos; Swart, Arno; Gortemaker, Betty; Dierikx, Cindy; Havelaar, Arie; Schmitt, Heike

    2015-01-01

    Whilst broilers are recognised as a reservoir of extended-spectrum-β-lactamase (ESBL)- and AmpC-β-lactamase (AmpC)-producing Escherichia coli, there is currently limited knowledge on the effect of slaughtering on its concentrations on poultry meat. The aim of this study was to establish the conce

  9. Reduction of extended-spectrum-β-lactamase- and AmpC-β-lactamase-producing Escherichia coli through processing in two broiler chicken slaughterhouses

    NARCIS (Netherlands)

    Pacholewicz, Ewa; Liakopoulos, Apostolos; Swart, Arno; Gortemaker, Betty; Dierikx, Cindy; Havelaar, Arie; Schmitt, Heike

    2015-01-01

    Whilst broilers are recognised as a reservoir of extended-spectrum-β-lactamase (ESBL)- and AmpC-β-lactamase (AmpC)-producing Escherichia coli, there is currently limited knowledge on the effect of slaughtering on its concentrations on poultry meat. The aim of this study was to establish the concentr

  10. cAMP Stimulation of HCO3- Secretion Across Airway Epithelia

    Directory of Open Access Journals (Sweden)

    Welsh MJ

    2001-07-01

    Full Text Available To test for the presence of HCO(3(- transport across airway epithelia, we measured short-circuit current in primary cultures of canine and human airway epithelia bathed in a Cl(--free, HCO(3(-/CO(2-buffered solution. cAMP agonists stimulated a secretory current that was likely carried by HCO(3(- because it was absent in HCO(3(--free solutions. In addition, the cAMP-stimulated current was inhibited by the carbonic anhydrase inhibitor, acetazolamide, and by the apical addition of a blocker of cystic fibrosis transmembrane conductance regulator (CFTR, diphenylamine-2-carboxylate. The current was dependent on Na(+ because it was inhibited by removing Na(+ from the submucosal solution and by inhibition of the Na(+-K(+-ATPase with ouabain. The cAMP-stimulated current was absent in cystic fibrosis (CF airway epithelia. These data suggest that cAMP agonists can stimulate HCO(3(- secretion across airway epithelia and that CFTR may provide a conductive pathway for HCO(3(- movement across the apical membrane.

  11. Charge carrier transport in Cu(In,Ga)Se{sub 2} thin-film solar-cells studied by electron beam induced current and temperature and illumination dependent current voltage analysis

    Energy Technology Data Exchange (ETDEWEB)

    Nichterwitz, Melanie

    2012-01-10

    This work contributes to the understanding of generation dependent charge-carrier transport properties in Cu(In,Ga)Se{sub 2} (CIGSe)/ CdS/ ZnO solar cells and a consistent model for the electronic band diagram of the heterojunction region of the device is developed. Cross section electron-beam induced current (EBIC) and temperature and illumination dependent current voltage (IV) measurements are performed on CIGSe solar cells with varying absorber layer compositions and CdS thickness. For a better understanding of possibilities and limitations of EBIC measurements applied on CIGSe solar cells, detailed numerical simulations of cross section EBIC profiles for varying electron beam and solar cell parameters are performed and compared to profiles obtained from an analytical description. Especially the effects of high injection conditions are considered. Even though the collection function of the solar cell is not independent of the generation function of the electron beam, the local electron diffusion length in CIGSe can still be extracted. Grain specific values ranging from (480±70) nm to (2.3±0.2) μm are determined for a CuInSe{sub 2} absorber layer and a value of (2.8±0.3) μm for CIGSe with a Ga-content of 0.3. There are several models discussed in literature to explain generation dependent charge carrier transport, all assuming a high acceptor density either located in the CIGSe layer close to the CIGSe/CdS interface (p{sup +} layer), within the CdS layer or at the CdS/ZnO interface. In all models, a change in charge carrier collection properties is caused by a generation dependent occupation probability of the acceptor type defect state and the resulting potential distribution throughout the device. Numerical simulations of EBIC and IV data are performed with parameters according to these models. The model that explains the experimental data best is that of a p{sup +} layer at the CIGSe/CdS interface and acceptor type defect states at the CdS/ZnO interface

  12. 7 CFR 772.14 - Reamortization of AMP loans.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Reamortization of AMP loans. 772.14 Section 772.14... AGRICULTURE SPECIAL PROGRAMS SERVICING MINOR PROGRAM LOANS § 772.14 Reamortization of AMP loans. The Agency may approve reamortization of AMP loans provided: (a) There is no extension of the final maturity...

  13. S-AMP: Approximate Message Passing for General Matrix Ensembles

    DEFF Research Database (Denmark)

    Cakmak, Burak; Winther, Ole; Fleury, Bernard H.

    2014-01-01

    We propose a novel iterative estimation algorithm for linear observation models called S-AMP. The fixed points of S-AMP are the stationary points of the exact Gibbs free energy under a set of (first- and second-) moment consistency constraints in the large system limit. S-AMP extends...

  14. Catastrophic flank collapses and slumping in Pico Island during the last 130 kyr (Pico-Faial ridge, Azores Triple Junction)

    Science.gov (United States)

    Costa, A. C. G.; Hildenbrand, A.; Marques, F. O.; Sibrant, A. L. R.; Santos de Campos, A.

    2015-09-01

    The Pico Island constitutes the easternmost sub-aerial domain of a steep WNW-ESE volcanic ridge, which has developed within the Nubia-Eurasia diffuse plate boundary (Azores Triple Junction). The island comprises three volcanic systems, from older to younger: the Topo Volcano, the Fissural System, and the Pico Stratovolcano. From a high-resolution Digital Elevation Model (10 m), and new bathymetric, stratigraphic, structural, and high-precision K-Ar data, we reconstruct the main successive stages of growth and partial destruction of the island over the last 200 kyr. We especially concentrate on the central sector of the island, which has recorded gradual movements through slumping and catastrophic flank collapses since ca. 130 kyr. The remmants of the Topo Volcano are partly exposed on Pico's SE flank, and are here dated between 186 ± 5 and 115 ± 4 ka. Topo was significantly destroyed by N- and S-directed large-scale flank collapses between ca. 125 and 70 ka. On Pico's N flank, collapse seems to have removed all the unstable material, but in the S the collapse structure is composite, including a major flank collapse and a remnant slump complex that is still active. A first episode of deformation occurred between ca. 125 and 115 ka along the master fault of the slump. Between ca. 115 and 69 ka, most of the unstable material was removed by a major flank collapse, leaving behind a still considerable volume of unstable material that comprises the active slump. This first collapse was catastrophic and generated a large debris deposit recognized on the high-resolution bathymetry, with a minimum run-out of ca. 17 km. The scar was partially filled by volcanic products erupted from volcanic cones developed within the slump depression, and possibly also from the early WNW-ESE Fissural System. Subsequent deformation in the slump area affected in part the filling units, leading to the individualization of secondary curved faults. Younger volcanic products have gradually

  15. Slice of the LHC prototype beam tubes in dipole magnet

    CERN Multimedia

    1995-01-01

    A slice of the LHC accelerator prototype beam tubes surrounded by magnets. The LHC will accelerate two proton beams in opposite directions. The high bending and accelerating fields needed can only be reached using superconductors. At very low temperatures superconductors have no electrical resistance and therefore no power loss. The LHC will be the largest superconducting installation ever built, a unique challenge for CERN and its industrial partners. About dipole magnets: There will be 1232 dipole magnets in the LHC, used to guide the particles around the 27 km ring. Dipole magnets must have an extremely uniform field, which means the current flowing in the coils has to be very precisely controlled. Nowhere before has such precision been achieved at such high currents. The temperature is measured to five thousandths of a degree, the current to one part in a million. The current creating the magnetic field will pass through superconducting wires at up to 12 500 amps, about 30 000 times the current flowing ...

  16. Proteomic signatures implicate cAMP in light and temperature responses in Arabidopsis thaliana

    KAUST Repository

    Thomas, Ludivine

    2013-05-01

    The second messenger 3\\'-5\\'-cyclic adenosine monophosphate (cAMP) and adenylyl cyclases (ACs), enzymes that catalyse the formation of cAMP from ATP, are increasingly recognized as important signaling molecules in a number of physiological responses in higher plants. Here we used proteomics to identify cAMP-dependent protein signatures in Arabidopsis thaliana and identify a number of differentially expressed proteins with a role in light- and temperature-dependent responses, notably photosystem II subunit P-1, plasma membrane associated cation-binding protein and chaperonin 60 β. Based on these proteomics results we conclude that, much like in cyanobacteria, algae and fungi, cAMP may have a role in light signaling and the regulation of photosynthesis as well as responses to temperature and we speculate that ACs could act as light and/or temperature sensors in higher plants. Biological significance: This current study is significant since it presents the first proteomic response to cAMP, a novel and key second messenger in plants. It will be relevant to researchers in plant physiology and in particular those with an interest in second messengers and their role in biotic and abiotic stress responses. © 2013 Elsevier B.V.

  17. Retromer terminates the generation of cAMP by internalized PTH receptors.

    Science.gov (United States)

    Feinstein, Timothy N; Wehbi, Vanessa L; Ardura, Juan A; Wheeler, David S; Ferrandon, Sebastien; Gardella, Thomas J; Vilardaga, Jean-Pierre

    2011-05-01

    The generation of cAMP by G protein-coupled receptors (GPCRs) and its termination are currently thought to occur exclusively at the plasma membrane of cells. Under existing models of receptor regulation, this signal is primarily restricted by desensitization of the receptors through their binding to β-arrestins. However, this paradigm is not consistent with recent observations that the parathyroid hormone receptor type 1 (PTHR) continues to stimulate cAMP production even after receptor internalization, as β-arrestins are known to rapidly bind and internalize activated PTHR. Here we show that binding to β-arrestin1 prolongs rather than terminates the generation of cAMP by PTHR, and that cAMP generation correlates with the persistence of arrestin-receptor complexes on endosomes. PTHR signaling is instead turned off by the retromer complex, which regulates the movement of internalized receptor from endosomes to the Golgi apparatus. Thus, binding by the retromer complex regulates the sustained generation of cAMP triggered by an internalized GPCR.

  18. Retromer terminates the generation of cAMP by internalized PTH-receptors

    Science.gov (United States)

    Feinstein, Timothy N.; Wehbi, Vanessa L.; Ardura, Juan; Wheeler, David S.; Ferrandon, Sebastien; Gardella, Thomas J.; Vilardaga, Jean-Pierre

    2011-01-01

    Generation of cAMP by G protein–coupled receptors (GPCRs) and its termination is currently thought to occur exclusively at the plasma membrane of cells. Under existing models of receptor regulation, this signal is primarily restricted by desensitizationof the receptors through their binding to β-arrestins. However, this paradigm is not consistent with recent observations that the parathyroid hormone receptor type 1 (PTHR) continues to stimulate cAMP production even after receptor internalization, as β-arrestins are known to rapidly bind and internalize activated PTHR. Here we show that β-arrestin1 binding prolongs rather than terminates cAMP generation by PTHR, and that cAMP generation correlates with the persistence of arrestin-receptor complexes on endosomes. We found that PTHR signaling is instead turned-off by the retromer complex, which regulates traffic of internalized receptor from endosomes to the Golgi apparatus. Thus, binding by the retromer complex regulates sustained cAMP generation triggered by an internalized GPCR. PMID:21445058

  19. Simulations of beam-beam and beam-wire interactions in RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyung J.; Sen, Tanaji; /Fermilab; Abreu, Natalia P.; Fischer, Wolfram; /Brookhaven

    2009-02-01

    The beam-beam interaction is one of the dominant sources of emittance growth and luminosity lifetime deterioration. A current carrying wire has been proposed to compensate long-range beam-beam effects in the LHC and strong localized long-range beam-beam effects are experimentally investigated in the RHIC collider. Tune shift, beam transfer function, and beam loss rate are measured in dedicated experiments. In this paper, they report on simulations to study the effect of beam-wire interactions based on diffusive apertures, beam loss rates, and beam transfer function using a parallelized weak-strong beam simulation code (BBSIMC). The simulation results are compared with measurements performed in RHIC during 2007 and 2008.

  20. A Method for Studying cAMP-relay in Dictyostelium discoideum : the Effect of Temperature on cAMP-relay

    NARCIS (Netherlands)

    Haastert, Peter J.M. van

    1984-01-01

    A simple assay has been developed to quantify the cAMP-relay in Dictyostelium discoideum. The assay is based on the stimulation of cells, in the presence of a phosphodiesterase inhibitor, with 2'-deoxyadenosine 3',5'-monophosphate (dcAMP) at a concentration which saturates cell surface cAMP receptor

  1. ALICE Injected Beam Accidents

    CERN Document Server

    Appleby, R B

    2009-01-01

    The ALICE (point 2) interaction region is sensitive to beam orbit errors arising from magnet setting errors on injection. In this report, beam accident scenarios under injection for ALICE are described, focusing on ultra- fast error injection scenarios for the interaction straight correctors and dipoles. Beam 1 and beam 2 accident scenarios are considered, where the errors can lead to beam orbits striking the ALICE vacuum chamber or elements of the machine. The required thresholds for magnet current interlocks are calculated to avoid machine and detector risk.

  2. LHCb Injected Beam Accidents

    CERN Document Server

    Appleby, R B

    2009-01-01

    The LHCb (point 8) interaction region is sensitive to beam orbit errors arising from magnet setting errors on injection. In this report, beam accident scenarios under injection for LHCb are described, focusing on ultra- fast error injection scenarios for the interaction straight correctors and dipoles. Beam 1 and beam 2 accident scenarios are considered, where the errors can lead to beam orbits striking the LHCb vacuum chamber or elements of the machine. The required thresholds for magnet current interlocks are calculated to avoid machine and detector risk.

  3. Core-shell InGaN/GaN nanowire light emitting diodes analyzed by electron beam induced current microscopy and cathodoluminescence mapping.

    Science.gov (United States)

    Tchernycheva, M; Neplokh, V; Zhang, H; Lavenus, P; Rigutti, L; Bayle, F; Julien, F H; Babichev, A; Jacopin, G; Largeau, L; Ciechonski, R; Vescovi, G; Kryliouk, O

    2015-07-21

    We report on the electron beam induced current (EBIC) microscopy and cathodoluminescence (CL) characterization correlated with compositional analysis of light emitting diodes based on core/shell InGaN/GaN nanowire arrays. The EBIC mapping of cleaved fully operational devices allows to probe the electrical properties of the active region with a nanoscale resolution. In particular, the electrical activity of the p-n junction on the m-planes and on the semi-polar planes of individual nanowires is assessed in top view and cross-sectional geometries. The EBIC maps combined with CL characterization demonstrate the impact of the compositional gradients along the wire axis on the electrical and optical signals: the reduction of the EBIC signal toward the nanowire top is accompanied by an increase of the CL intensity. This effect is interpreted as a consequence of the In and Al gradients in the quantum well and in the electron blocking layer, which influence the carrier extraction efficiency. The interface between the nanowire core and the radially grown layer is shown to produce in some cases a transitory EBIC signal. This observation is explained by the presence of charged traps at this interface, which can be saturated by electron irradiation.

  4. Mechanisms of hardening, wear and corrosion improvement of 316 L stainless steel by low energy high current pulsed electron beam surface treatment

    Energy Technology Data Exchange (ETDEWEB)

    Zou, J.X. [Laboratoire d' Etude des Textures et Applications aux Materiaux (LETAM, UMR-CNRS 7078), Universite Paul Verlaine - Metz, Ile du Saulcy, 57045 Metz (France); Shanghai Engineering Research Center of Mg Materials and Applications and School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240 (China); Key Laboratory of Materials Modification by Laser, Electron and Ion beams, Dalian University of Technology, Dalian 116024 (China); Zhang, K.M. [School of Materials Engineering, Shanghai University of Engineering Science, Shanghai 201620 (China); Hao, S.Z.; Dong, C. [Key Laboratory of Materials Modification by Laser, Electron and Ion beams, Dalian University of Technology, Dalian 116024 (China); Grosdidier, T., E-mail: thierry.grosdidier@univ-metz.f [Laboratoire d' Etude des Textures et Applications aux Materiaux (LETAM, UMR-CNRS 7078), Universite Paul Verlaine - Metz, Ile du Saulcy, 57045 Metz (France); Key Laboratory of Materials Modification by Laser, Electron and Ion beams, Dalian University of Technology, Dalian 116024 (China)

    2010-12-01

    The mechanisms of corrosion and wear improvements by low energy high current pulsed electron beam (LEHCPEB) have been investigated for an AISI 316 L steel. Selective purification followed by epitaxial growth occurred in the top surface melted layer (2-3 {mu}m thick) that was softened by tensile stresses and, to a much lower extent, by lower efficiency of MnS precipitation hardening. Electrochemical impedance spectroscopy and potentiodynamic polarization analyses used to model the corrosion behavior revealed that, while craters initiated at MnS inclusions initially served as pitting sites, the resistance was increased by 3 orders of magnitude after sufficient number of pulses by the formation of a homogeneous covering layer. The wear resistance was effectively improved by sub-surface (over 100 {mu}m) work hardening associated with the combine effect of the quasi-static thermal stress and the thermal stress waves. The overall results demonstrate the potential of the LEHCPEB technique for improving concomitantly the corrosion and wear performances of metallic materials.

  5. Study on the nanostructure formation mechanism of hypereutectic Al–17.5Si alloy induced by high current pulsed electron beam

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Bo, E-mail: gaob@smm.neu.edu.cn [School of Materials and Metallurgy, Northeastern University, Shenyang 110004 (China); Hu, Liang [School of Materials and Metallurgy, Northeastern University, Shenyang 110004 (China); Li, Shi-wei [School of Materials and Metallurgy, Northeastern University, Shenyang 110004 (China); Faculty of Metallurgical and Energy Engineering, Kunming University of Science and Technology, Kunming 650093 (China); Hao, Yi [School of Materials and Metallurgy, Northeastern University, Shenyang 110004 (China); Zhang, Yu-dong [Laboratoire d’Etude des Textures et Applications aux Matériaux (LETAM, UMR-CNRS 7078), Université Paul Verlaine de Metz, Ile du Saulcy, Metz 57012 (France); Tu, Gan-feng [School of Materials and Metallurgy, Northeastern University, Shenyang 110004 (China); Grosdidier, Thierry [Laboratoire d’Etude des Textures et Applications aux Matériaux (LETAM, UMR-CNRS 7078), Université Paul Verlaine de Metz, Ile du Saulcy, Metz 57012 (France)

    2015-08-15

    This work investigates the nanostructure forming mechanism of hypereutectic Al–17.5Si alloy associated with the high current pulsed electron beam (HCPEB) treatment with increasing number of pulses by electron backscatter diffraction (EBSD) and SEM. The surface layers were melted and resolidified rapidly. The treated surfaces show different structural characteristics in different compositions and distribution zones. The top melted-layer zone can be divided into three zones: Si-rich, Ai-rich, and intermediate zone. The Al-rich zone has a nano-cellular microstructure with a diameter of ∼100 nm. The microstructure in the Si-rich zone consists of fine, dispersive, and spherical nano-sized Si crystals surrounded by α(Al) cells. Some superfine eutectic structures form in the boundary of the two zones. With the increase of number of pulses, the proportion of Si-rich zone to the whole top surface increases, and more cellular substructures are transformed to fine equiaxed grain. In other words, with increasing number of pulses, more Si elements diffuse to the Al-rich zone and provide heterogeneous nucleation sites, and Al grains are refined dramatically. Moreover, the relationship between the substrate Si phase and crystalline phase is determined by EBSD; that is, (1 1 1){sub Al}//(0 0 1){sub Si} with a value of disregistry δ at approximately 5%. The HCPEB technique is a versatile technique for refining the surface microstructure of hypereutectic Al–Si alloys.

  6. Formation of microcraters and hierarchically-organized surface structures in TiNi shape memory alloy irradiated with a low-energy, high-current electron beam

    Energy Technology Data Exchange (ETDEWEB)

    Meisner, L. L., E-mail: llm@ispms.tsc.ru; Meisner, S. N., E-mail: myp@ispms.tsc.ru [Institute of Strength Physics and Materials Science SB RAS, Tomsk, 634055 (Russian Federation); National Research Tomsk State University, Tomsk, 634050 (Russian Federation); Markov, A. B., E-mail: a.markov@hq.tsc.ru; Ozur, G. E., E-mail: vrotshtein@yahoo.com; Yakovlev, E. V., E-mail: msn@ispms.tsc.ru [Institute of High Current Electronics SB RAS, Tomsk, 634055 (Russian Federation); Rotshtein, V. P., E-mail: yakovev@lve.hcei.tsc.ru [Institute of Strength Physics and Materials Science SB RAS, Tomsk, 634055 (Russian Federation); Tomsk State Pedagogical University, Tomsk, 634050 (Russian Federation); Gudimova, E. Yu., E-mail: ozur@lve.hcei.tsc.ru [Institute of Strength Physics and Materials Science SB RAS, Tomsk, 634055 (Russian Federation)

    2015-10-27

    The regularities of surface cratering in TiNi alloy irradiated with a low-energy, high-current electron beam (LEHCEB) in dependence on energy density and number of pulses are studied. LEHCEB processing of TiNi samples was carried out using RITM-SP facility. Energy density E{sub s} was varied from 1 to 5 J/cm{sup 2}, pulse duration was 2.5–3.0 μs, the number of pulses n = 1–128. The dominant role of non-metallic inclusions [mainly, TiC(O)] in the nucleation of microcraters was found. It was revealed that at small number of pulses (n = 2), an increase in energy density leads both to increasing average diameter and density of microcraters. An increase in the number of pulses leads to a monotonic decrease in density of microcraters, and, therefore, that of the proportion of the area occupied by microcraters, as well as a decrease in the surface roughness. The multiple LEHCEB melting of TiNi alloy in crater-free modes enables to form quasi-periodical, hierarchically-organized microsized surface structures.

  7. Thermal Cycling Behavior of Thermal Barrier Coatings with MCrAlY Bond Coat Irradiated by High-Current Pulsed Electron Beam.

    Science.gov (United States)

    Cai, Jie; Lv, Peng; Guan, Qingfeng; Xu, Xiaojing; Lu, Jinzhong; Wang, Zhiping; Han, Zhiyong

    2016-11-30

    Microstructural modifications of a thermally sprayed MCrAlY bond coat subjected to high-current pulsed electron beam (HCPEB) and their relationships with thermal cycling behavior of thermal barrier coatings (TBCs) were investigated. Microstructural observations revealed that the rough surface of air plasma spraying (APS) samples was significantly remelted and replaced by many interconnected bulged nodules after HCPEB irradiation. Meanwhile, the parallel columnar grains with growth direction perpendicular to the coating surface were observed inside these bulged nodules. Substantial Y-rich Al2O3 bubbles and varieties of nanocrystallines were distributed evenly on the top of the modified layer. A physical model was proposed to describe the evaporation-condensation mechanism taking place at the irradiated surface for generating such surface morphologies. The results of thermal cycling test showed that HCPEB-TBCs presented higher thermal cycling resistance, the spalling area of which after 200 cycles accounted for only 1% of its total area, while it was about 34% for APS-TBCs. The resulting failure mode, i.e., in particular, a mixed delamination crack path, was shown and discussed. The irradiated effects including compact remelted surface, abundant nanoparticles, refined columnar grains, Y-rich alumina bubbles, and deformation structures contributed to the formation of a stable, continuous, slow-growing, and uniform thermally grown oxide with strong adherent ability. It appeared to be responsible for releasing stress and changing the cracking paths, and ultimately greatly improving the thermal cycling behavior of HCPEB-TBCs.

  8. Electron-beam-induced current measurements with applied bias provide insight to locally resolved acceptor concentrations at p-n junctions

    Energy Technology Data Exchange (ETDEWEB)

    Abou-Ras, D., E-mail: daniel.abou-ras@helmholtz-berlin.de; Schäfer, N.; Baldaz, N.; Brunken, S. [Helmholtz-Zentrum Berlin für Materialien und Energie, Hahn-Meitner-Platz 1, 14109 Berlin (Germany); Boit, C. [Technische Universität Berlin, Department of Semiconductor Devices, Einsteinufer 19, 10587 Berlin (Germany)

    2015-07-15

    Electron-beam-induced current (EBIC) measurements have been employed for the investigation of the local electrical properties existing at various types of electrical junctions during the past decades. In the standard configuration, the device under investigation is analyzed under short-circuit conditions. Further insight into the function of the electrical junction can be obtained when applying a bias voltage. The present work gives insight into how EBIC measurements at applied bias can be conducted at the submicrometer level, at the example of CuInSe{sub 2} solar cells. From the EBIC profiles acquired across ZnO/CdS/CuInSe{sub 2}/Mo stacks exhibiting p-n junctions with different net doping densities in the CuInSe{sub 2} layers, values for the width of the space-charge region, w, were extracted. For all net doping densities, these values decreased with increasing applied voltage. Assuming a linear relationship between w{sup 2} and the applied voltage, the resulting net doping densities agreed well with the ones obtained by means of capacitance-voltage measurements.

  9. Wire Scanner Beam Profile Measurements: LANSCE Facility Beam Development

    Energy Technology Data Exchange (ETDEWEB)

    Gilpatrick, John D. [Los Alamos National Laboratory; Batygin, Yuri K. [Los Alamos National Laboratory; Gonzales, Fermin [Los Alamos National Laboratory; Gruchalla, Michael E. [Los Alamos National Laboratory; Kutac, Vincent G. [Los Alamos National Laboratory; Martinez, Derwin [Los Alamos National Laboratory; Sedillo, James Daniel [Los Alamos National Laboratory; Pillai, Chandra [Los Alamos National Laboratory; Rodriguez Esparza, Sergio [Los Alamos National Laboratory; Smith, Brian G. [Los Alamos National Laboratory

    2012-05-15

    The Los Alamos Neutron Science Center (LANSCE) is replacing Wire Scanner (WS) beam profile measurement systems. Three beam development tests have taken place to test the new wire scanners under beam conditions. These beam development tests have integrated the WS actuator, cable plant, electronics processors and associated software and have used H{sup -} beams of different beam energy and current conditions. In addition, the WS measurement-system beam tests verified actuator control systems for minimum profile bin repeatability and speed, checked for actuator backlash and positional stability, tested the replacement of simple broadband potentiometers with narrow band resolvers, and tested resolver use with National Instruments Compact Reconfigurable Input and Output (cRIO) Virtual Instrumentation. These beam tests also have verified how trans-impedance amplifiers react with various types of beam line background noise and how noise currents were not generated. This paper will describe these beam development tests and show some resulting data.

  10. Functional desensitization to isoproterenol without reducing cAMP production in canine failing cardiocytes.

    Science.gov (United States)

    Laurent, C E; Cardinal, R; Rousseau, G; Vermeulen, M; Bouchard, C; Wilkinson, M; Armour, J A; Bouvier, M

    2001-02-01

    To corroborate alterations in the functional responses to beta-adrenergic receptor (beta-AR) stimulation with changes in beta-AR signaling in failing cardiomyocytes, contractile and L-type Ca(2+) current responses to isoproterenol along with stimulated cAMP generation were compared among cardiomyocytes isolated from canines with tachycardia-induced heart failure or healthy hearts. The magnitude of shortening of failing cardiomyocytes was significantly depressed (by 22 +/- 4.4%) under basal conditions, and the maximal response to isoproterenol was significantly reduced (by 45 +/- 18%). Similar results were obtained when the responses in the rate of contraction and rate of relaxation to isoproterenol were considered. The L-type Ca(2+) current amplitude measured in failing cardiomyocytes under basal conditions was unchanged, but the responses to isoproterenol were significantly reduced compared with healthy cells. Isoproterenol-stimulated cAMP generation was similar in sarcolemmal membranes derived from the homogenates of failing (45 +/- 6.8) and healthy cardiomyocytes (52 +/- 8.5 pmol cAMP. mg protein(-1). min(-1)). However, stimulated cAMP generation was found to be significantly reduced when the membranes were derived from the homogenates of whole tissue (failing: 67 +/- 8.1 vs. healthy: 140 +/- 27.8 pmol cAMP. mg protein(-1). min(-1)). Total beta-AR density was not reduced in membranes derived from either whole tissue or isolated cardiomyocyte homogenates, but the beta(1)/beta(2) ratio was significantly reduced in the former (failing: 45/55 vs. healthy: 72/28) without being altered in the latter (failing: 72/28, healthy: 77/23). We thus conclude that, in tachycardia-induced heart failure, reduction in the functional responses of isolated cardiomyocytes to beta-AR stimulation may be attributed to alterations in the excitation-contraction machinery rather than to limitation of cAMP generation.

  11. Glacial Delineation and Ice Retreat on Pico de Orizaba, Mexico

    Science.gov (United States)

    Colby, A. E.; Weissling, B.; Xie, H.

    2011-12-01

    Pico de Orizaba, a dormant stratovolcano at the eastern end of the Trans-Mexican Volcanic Belt at approximately 19 degrees of latitude and the third largest peak in North America (5636 m), hosts what is likely the last significant tropical zone glacier (Jamapa Glacier) in the Northern Hemisphere. Not since the International Geophysical Year of 1957-58 has Pico's glacial environment been studied with any focused effort, perhaps due to the general innaccessibility, high altitude, and steep slopes. As are most glaciers around the world, the Jamapa Glacier is retreating, with a remarkable loss of ice in the past 2 decades. The rate and pattern of retreat is important to understanding climate change forcing as well as understanding environmental and water supply impacts to a substantial human population who live along the base of the volcano. Through the use of satellite imagery (LandSat, ASTER, IKONOS), legacy hand-drawn maps, aerial photographs, and first-hand accounts from climber's expeditions, a reasonably accurate map of almost 60 years of glacial retreat has been produced. Legacy hand-drawn maps of the ice edge, that pre-date the satellite era, did not fit perfectly with modern images when layered in ArcGIS. Oblique perspectives in Google Earth and various aerial and surface-based photographs of the mountain were used to help fit the ice edge to the actual topography. The disparity of satellite image pixel resolution (from 1 m IKONOS to 60 m LandSat) was addressed using various imagery analysis tools (eg. edge detection convolution filters and pixel unmixing) in order to delineate an approximate ice edge for the respective image date. The final map shows the nature of ice edge retreat on Pico de Orizaba from 1945 up until the present (Feb 2011).

  12. Lo utópico de la Universidad

    Directory of Open Access Journals (Sweden)

    César Mureddu Torres

    2004-01-01

    Full Text Available El presente escrito estudia y expone lo que puede ser calificado como utópico en lo que la Universidad genera. Se distinguen al menos tres ámbitos en el mismo: el actuar de la Universidad en cuanto tal, la función de espejo, esperanza y contraste que la Universidad puede tener para con la sociedad y el que la Universidad no pueda guiarse por lo que expresamente digan sus miembros en formación. A pesar de todo ello lo que hace la Universidad no es un despropósito.

  13. Pico Veleta Atmospheric Noise Limits at Millimeter Wavelengths

    Science.gov (United States)

    Benford, Dominic J.

    2010-01-01

    In November 2007 and October 2008, we demonstrated a new camera for the 2 mm wavelength band, GISMO (Goddard IRAM Superconducting 2 Millimeter Observer), at the IRAM 30 m telescope in Spain. Based on a novel superconducting transition edge sensor bolometer array, GISMO features a compact optical design that should provide rapid imaging in its band. We detail the calculations made for GISMO to determine the atmospheric emission optical loading and resultant photon noise in the 2 mm band at Pico Veleta, and show confirming measurements obtained during the observing runs.

  14. A Pico Projector Source for Confocal Fluorescence and Ophthalmic Imaging.

    Science.gov (United States)

    Muller, Matthew S

    2012-09-02

    A Pico digital light projector has been implemented as an integrated illumination source and spatial light modulator for confocal imaging. The target is illuminated with a series of rapidly projected lines or points to simulate scanning. Light returning from the target is imaged onto a 2D rolling shutter CMOS sensor. By controlling the spatio-temporal relationship between the rolling shutter and illumination pattern, light returning from the target is spatially filtered. Confocal retinal, fluorescence, and Fourier-domain optical coherence tomography implementations of this novel imaging technique are presented.

  15. Hallazgo endoscópico de linfoma folicular primario

    OpenAIRE

    Diana L. Franco; Sameer Islam; Kevin Ruff

    2015-01-01

    Una mujer de 79 años, sin antecedentes patológicos de importancia, consultó al servicio de gastro-enterología por síntomas de dispepsia de larga data. Se practicó una esofagogastroduodenoscopia en la que se observó mucosa nodular en la segunda porción del duodeno. Esta morfología y los hallazgos inmunofenotípicos eran indicativos de linfoma folicular de bajo grado. El propósito de este manuscrito es ilustrar al lector sobre esta inusual condición en el duodeno, la cual es patognomónica de lin...

  16. Tratamiento artroscópico en pacientes con gonartrosis primaria

    OpenAIRE

    Álvarez López, Alejandro

    2013-01-01

    La artrosis de rodilla (gonartrosis) primaria afecta cada día un mayor número de personas, incluso en edades tempranas con evidentes fracasos al tratamiento conservador. Los procedimientos artroscópicos pueden ser efectivos en más de la mitad de los enfermos que presentan síntomas y signos persistentes por más de seis semanas. Sin embargo, sus beneficios estarán en dependencia de varios factores. Para corroborar este planteamiento se realizó un estudio de diseño cuasi experimental modalidad a...

  17. Tratamiento artroscópico en pacientes con gonartrosis primaria

    OpenAIRE

    2013-01-01

    La artrosis de rodilla (gonartrosis) primaria afecta cada día un mayor número de personas, incluso en edades tempranas con evidentes fracasos al tratamiento conservador. Los procedimientos artroscópicos pueden ser efectivos en más de la mitad de los enfermos que presentan síntomas y signos persistentes por más de seis semanas. Sin embargo, sus beneficios estarán en dependencia de varios factores. Para corroborar este planteamiento se realizó un estudio de diseño cuasi experimental modalidad a...

  18. Três Tópicos em economia comportamental

    OpenAIRE

    2013-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Sócio-Econômico, Programa de Pós-Graduação em Economia, Florianópolis, 2013. Esta dissertação apresenta três tópicos em economia comportamental. O primeiro trata de verificar se há correlação entre orientação de valor social e escolha intertemporal. Observou-se que indivíduos mais pró-sociais tendem a ser mais pacientes. O segundo trata de alterar o teste conhecido por CRT (Cognitive Reflexion Test), objetivando verifi...

  19. O abuso de medicamentos psicotrópicos na contemporaneidade

    Directory of Open Access Journals (Sweden)

    Marta Regueira Fonseca Pelegrini

    Full Text Available O artigo propõe uma análise crítica do fenômeno do abuso de medicamentos psicotrópicos na atualidade. A base teórica é a psicanálise. A argumentação parte da discussão da subjetividade contemporânea, resgatando o conceito de mal-estar na civilização em Freud, para elucidar algumas das causas e dos efeitos desse fato atual.

  20. modlAMP: Python for antimicrobial peptides.

    Science.gov (United States)

    Müller, Alex T; Gabernet, Gisela; Hiss, Jan A; Schneider, Gisbert

    2017-09-01

    We have implemented the lecular esign aboratory's nti icrobial eptides package ( ), a Python-based software package for the design, classification and visual representation of peptide data. modlAMP offers functions for molecular descriptor calculation and the retrieval of amino acid sequences from public or local sequence databases, and provides instant access to precompiled datasets for machine learning. The package also contains methods for the analysis and representation of circular dichroism spectra. The modlAMP Python package is available under the BSD license from URL http://doi.org/10.5905/ethz-1007-72 or via pip from the Python Package Index (PyPI). gisbert.schneider@pharma.ethz.ch. Supplementary data are available at Bioinformatics online.

  1. A Low Power Op Amp for 3-Bit Digital to Analog Converter in 0.18 µm CMOS Process

    Directory of Open Access Journals (Sweden)

    Noor A.B.A. Taib

    2013-03-01

    Full Text Available Digital to (DAC is used to get analog voltage corresponding to input digital data in VLSI circuit design with greater integration levels. However, providing linear current and voltage outputs with the use of strictly CMOS devices presents the need for a low power operational amplifier (op-amp circuit. In this research, the analysis of op-amp circuit for 3-bit DAC is illustrated. In order to reduce the power dissipation, weighted resistor is utilized in the proposed design. To design the op-amp circuit for 3-bit DAC, the design has been implemented in CEDEC 0.18 µm CMOS process. The simulated result shows that, under 8 V as the supply voltage the total power dissipation for the proposed DAC is 43.6 nW. Moreover, 143.17 µm is found as the total chip area of the designed op-amp circuit for 3-bit DAC.

  2. The Monge-Ampère equation

    CERN Document Server

    Gutiérrez, Cristian E

    2016-01-01

    Now in its second edition, this monograph explores the Monge-Ampère equation and the latest advances in its study and applications. It provides an essentially self-contained systematic exposition of the theory of weak solutions, including regularity results by L. A. Caffarelli. The geometric aspects of this theory are stressed using techniques from harmonic analysis, such as covering lemmas and set decompositions. An effort is made to present complete proofs of all theorems, and examples and exercises are offered to further illustrate important concepts. Some of the topics considered include generalized solutions, non-divergence equations, cross sections, and convex solutions. New to this edition is a chapter on the linearized Monge-Ampère equation and a chapter on interior Hölder estimates for second derivatives. Bibliographic notes, updated and expanded from the first edition, are included at the end of every chapter for further reading on Monge-Ampère-type equations and their diverse applications in th...

  3. The Applied Mathematics for Power Systems (AMPS)

    Energy Technology Data Exchange (ETDEWEB)

    Chertkov, Michael [Los Alamos National Laboratory

    2012-07-24

    Increased deployment of new technologies, e.g., renewable generation and electric vehicles, is rapidly transforming electrical power networks by crossing previously distinct spatiotemporal scales and invalidating many traditional approaches for designing, analyzing, and operating power grids. This trend is expected to accelerate over the coming years, bringing the disruptive challenge of complexity, but also opportunities to deliver unprecedented efficiency and reliability. Our Applied Mathematics for Power Systems (AMPS) Center will discover, enable, and solve emerging mathematics challenges arising in power systems and, more generally, in complex engineered networks. We will develop foundational applied mathematics resulting in rigorous algorithms and simulation toolboxes for modern and future engineered networks. The AMPS Center deconstruction/reconstruction approach 'deconstructs' complex networks into sub-problems within non-separable spatiotemporal scales, a missing step in 20th century modeling of engineered networks. These sub-problems are addressed within the appropriate AMPS foundational pillar - complex systems, control theory, and optimization theory - and merged or 'reconstructed' at their boundaries into more general mathematical descriptions of complex engineered networks where important new questions are formulated and attacked. These two steps, iterated multiple times, will bridge the growing chasm between the legacy power grid and its future as a complex engineered network.

  4. Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2A, elevation of cAMP and activation of protein kinase A.

    Science.gov (United States)

    Módis, Katalin; Panopoulos, Panagiotis; Coletta, Ciro; Papapetropoulos, Andreas; Szabo, Csaba

    2013-11-01

    Although hydrogen sulfide (H₂S) is generally known as a mitochondrial poison, recent studies show that lower concentrations of H₂S play a physiological role in the stimulation of mitochondrial electron transport and cellular bioenergetics. This effect involves electron donation at Complex II. Other lines of recent studies demonstrated that one of the biological actions of H₂S involves inhibition of cAMP and cGMP phosphodiesterases (PDEs). Given the emerging functional role of the mitochondrial isoform of cAMP PDE (PDE2A) in the regulation of mitochondrial function the current study investigated whether cAMP-dependent mechanisms participate in the stimulatory effect of NaHS on mitochondrial function. In isolated rat liver mitochondria, partial digestion studies localized PDE2A into the mitochondrial matrix. NaHS exerted a concentration-dependent inhibitory effect on recombinant PDE2A enzyme in vitro. Moreover, NaHS induced an elevation of cAMP levels when added to isolated mitochondria and stimulated the mitochondrial electron transport. The latter effect was inhibited by Rp-cAMP, an inhibitor of the cAMP-dependent protein kinase (PKA). The current findings suggest that the direct electron donating effect of NaHS is amplified by an intramitochondrial cAMP system, which may involve the inhibition of PDE2A and subsequent, cAMP-mediated stimulation of PKA.

  5. Investigation of amorphous and crystalline Ni alloys response to machining with micro-second and pico-second lasers

    Energy Technology Data Exchange (ETDEWEB)

    Quintana, I., E-mail: iquintana@tekniker.es [CIC marGUNE, Pol. Ibaitarte 5, 20870, Elgoibar, Guipuzcoa (Spain); Dobrev, T. [Manufacturing Engineering Centre, Cardiff University, Cardiff, CF24 3AA (United Kingdom); Aranzabe, A. [Manufacturing Processes Department, Fundacion Tekniker, Av. Otaola 20, 2060, Eibar, Guipuzcoa (Spain); Lalev, G.; Dimov, S. [Manufacturing Engineering Centre, Cardiff University, Cardiff, CF24 3AA (United Kingdom)

    2009-04-15

    The machining response of amorphous and polycrystalline Ni-based alloys (Ni{sub 78}B{sub 14}Si{sub 8}) when subjected to micro-second and pico-second laser processing is investigated in this research. The shape and topography of craters created with single pulses as a function of laser energy together with holes drilled in both materials were studied. Focused ion beam (FIB) imaging was used to analyse the single craters and the through holes in the amorphous and polycrystalline samples. The material microstructure analysis revealed that processing both materials with micro-second and pico-second lasers does not lead to crystallisation and the short-range atomic ordering of metallic glasses can be retained. When processing the amorphous sample the material laser interactions resulted in a significant ejection of molten material from the bulk that was then followed by its partial re-deposition around the craters. Additionally, there were no signs of crack formation that indicate a higher surface integrity after laser machining. A conclusion is made that laser processing both with short- and long-pulses is a promising technique for micromachining metallic glasses because it does not lead to material crystallisation.

  6. Transverse Beam Size Effects in Beam Position Monitors

    Science.gov (United States)

    Kurennoy, Sergey

    2001-04-01

    The fields produced by a long beam with a given transverse charge distribution in a homogeneous vacuum chamber are studied. Signals induced by the displaced finite-size beam on electrodes of a beam position monitor (BPM) are calculated and compared to those from a pencil beam. The corrections to BPM signals due to a finite beam size are found analytically for a few particular transverse distributions of the beam current. The results for fields can also be directly applied for calculating the beam coupling impedances of small discontinuities.

  7. Cyclic AMP (cAMP) confers drug resistance against DNA damaging agents via PKAIA in CML cells.

    Science.gov (United States)

    Xiao, Ling-Yi; Kan, Wai-Ming

    2017-01-05

    Cyclic adenosine monophosphate (cAMP) regulates many vital functions such as metabolism, proliferation, differentiation and death. Depending on cell types and stimulators, cAMP could either promote or attenuate cell death. cAMP signal can be transduced by protein kinase A (PKA) and/or exchange protein directly activated by cAMP (EPAC). In CML cells, cAMP may suppress their proliferation and enhance their differentiation. However, the role of cAMP on DNA damaging agent toxicity and the mechanism involved has not been studied. In this study, we studied the effect of cAMP on the sensitivity of CML cells to DNA damaging agents. We observed that forskolin (FSK) and dibutyryl-cAMP (DBcAMP) decreased cisplatin and etoposide-induced cell death in K562 cells. Moreover, PKA activator prevented K562 cells from DNA damaging agent-induced cell death while EPAC activator had no effect. Furthermore, we found that the PKA subtype, PKAIA, was involved in cAMP-attenuated resistance in K562 cells. Taken together, our results suggest that increased cAMP level confers CML cells to acquire a novel mechanism against DNA damaging agent toxicity via PKAIA. Thus, PKAIA inhibitor may be helpful in overcoming the resistance to DNA damaging agents in CML cells.

  8. Simulation of excitation and propagation of pico-second ultrasound

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Seung Yong; Kim, No Hyu [Dept. of Mechanical Engineering, Korea University of Technology and Education, Chunan (Korea, Republic of)

    2016-12-15

    This paper presents an analytic and numerical simulation of the generation and propagation of pico-second ultrasound with nano-scale wavelength, enabling the production of bulk waves in thin films. An analytic model of laser-matter interaction and elasto-dynamic wave propagation is introduced to calculate the elastic strain pulse in microstructures. The model includes the laser-pulse absorption on the material surface, heat transfer from a photon to the elastic energy of a phonon, and acoustic wave propagation to formulate the governing equations of ultra-short ultrasound. The excitation and propagation of acoustic pulses produced by ultra-short laser pulses are numerically simulated for an aluminum substrate using the finite-difference method and compared with the analytical solution. Furthermore, Fourier analysis was performed to investigate the frequency spectrum of the simulated elastic wave pulse. It is concluded that a pico-second bulk wave with a very high frequency of up to hundreds of gigahertz is successfully generated in metals using a 100-fs laser pulse and that it can be propagated in the direction of thickness for thickness less than 100 nm.

  9. Riesgos antrópicos generados por la actividad minera

    Directory of Open Access Journals (Sweden)

    Ana Violeta Argüello Mejía

    2013-10-01

    Full Text Available Las actividades productivas generan riesgos antrópicos [1] a mediano y largo plazo. La zona de estudio se ubica en las Parroquias de Pomasqui, San Antonio y Calacalí, donde se han producido riesgos debido a las actividades humanas, en este caso, por la explotación de las canteras para abastecer el mercado de la construcción del Distrito Metropolitano de Quito. La investigación propone determinar los riesgos antrópicos generados por la actividad minera. Los pobladores de la zona identifican que la minería artesanal en sus inicios constituyó una fuente de trabajo, donde sus familias también se involucraban. Actualmente, se observa que en la mayoría de las canteras se utiliza maquinaria especializada y no participan los trabajadores de la zona. Los taludes de las canteras son de 80o y 90o grados, generando amenazas para los trabajadores y moradores de las viviendas aledañas. Uno de los mayores impactos es la contaminación del aire, sin embargo, el suelo y los cursos de agua están siendo afectados por los desperdicios que produce la actividad minera. La población, que está expuesta permanentemente al polvo ocasionado por las canteras y al transporte de material, acusa enfermedades de tipo respiratorio. Así mismo, el ruido ocasionado por el transporte constituye una molestia constante para los pobladores.

  10. Simulation of excitation and propagation of pico-second ultrasound

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Seung Yong; Kim, No Kyu [Dept. of Mechanical Engineering, Korea University of Technology and Education, Chunan (Korea, Republic of)

    2014-12-15

    This paper presents an analytic and numerical simulation of the generation and propagation of pico-second ultrasound with nano-scale wavelength, enabling the production of bulk waves in thin films. An analytic model of laser-matter interaction and elasto-dynamic wave propagation is introduced to calculate the elastic strain pulse in microstructures. The model includes the laser-pulse absorption on the material surface, heat transfer from a photon to the elastic energy of a phonon, and acoustic wave propagation to formulate the governing equations of ultra-short ultrasound. The excitation and propagation of acoustic pulses produced by ultra-short laser pulses are numerically simulated for an aluminum substrate using the finite-difference method and compared with the analytical solution. Furthermore, Fourier analysis was performed to investigate the frequency spectrum of the simulated elastic wave pulse. It is concluded that a pico-second bulk wave with a very high frequency of up to hundreds of gigahertz is successfully generated in metals using a 100-fs laser pulse and that it can be propagated in the direction of thickness for thickness less than 100 nm.

  11. Directed evolution of the Escherichia coli cAMP receptor protein at the cAMP pocket.

    Science.gov (United States)

    Gunasekara, Sanjiva M; Hicks, Matt N; Park, Jin; Brooks, Cory L; Serate, Jose; Saunders, Cameron V; Grover, Simranjeet K; Goto, Joy J; Lee, Jin-Won; Youn, Hwan

    2015-10-30

    The Escherichia coli cAMP receptor protein (CRP) requires cAMP binding to undergo a conformational change for DNA binding and transcriptional regulation. Two CRP residues, Thr(127) and Ser(128), are known to play important roles in cAMP binding through hydrogen bonding and in the cAMP-induced conformational change, but the connection between the two is not completely clear. Here, we simultaneously randomized the codons for these two residues and selected CRP mutants displaying high CRP activity in a cAMP-producing E. coli. Many different CRP mutants satisfied the screening condition for high CRP activity, including those that cannot form any hydrogen bonds with the incoming cAMP at the two positions. In vitro DNA-binding analysis confirmed that these selected CRP mutants indeed display high CRP activity in response to cAMP. These results indicate that the hydrogen bonding ability of the Thr(127) and Ser(128) residues is not critical for the cAMP-induced CRP activation. However, the hydrogen bonding ability of Thr(127) and Ser(128) was found to be important in attaining high cAMP affinity. Computational analysis revealed that most natural cAMP-sensing CRP homologs have Thr/Ser, Thr/Thr, or Thr/Asn at positions 127 and 128. All of these pairs are excellent hydrogen bonding partners and they do not elevate CRP activity in the absence of cAMP. Taken together, our analyses suggest that CRP evolved to have hydrogen bonding residues at the cAMP pocket residues 127 and 128 for performing dual functions: preserving high cAMP affinity and keeping CRP inactive in the absence of cAMP.

  12. Measurement of e{sup +}p neutral current deep inelastic scattering with a longitudinally polarised positron beam and X-ray radiation damage for silicon sensors

    Energy Technology Data Exchange (ETDEWEB)

    Januschek, Friederike

    2012-05-15

    The cross sections for Neutral Current e{sup +}p Deep Inelastic Scattering (NC DIS) with longitudinally polarised positron beams were measured at a centre-of-mass energy {radical}(s)=318 GeV using the ZEUS detector at HERA. Single-differential cross sections as a function of the virtuality of the exchanged boson, Q{sup 2}, of the inelasticity, y, and of the Bjorken scaling variable, x, and reduced cross sections (as a function of x and Q{sup 2}) were measured in the phase space region defined as Q{sup 2}>185 GeV{sup 2}, y<0.9 and y(1-x){sup 2}>0.004. The results, based on data corresponding to an integrated luminosity of 135.5 pb{sup -1}, are given for zero polarisation for the whole sample, as well as for both positive and negative values of the longitudinal polarisation of the positron beam. The measured cross sections are compared to the predictions of the Standard Model. The proton structure function xF{sub 3} is measured and the interference term xF{sup {gamma}}{sup Z}{sub 3} is extracted as a function of x at Q{sup 2}=1500 GeV{sup 2} by extrapolating the measurements done at different Q{sup 2} values. The presented measurements of the polarised e{sup +}p NC DIS cross sections, the xF{sub 3} structure function and the xF{sup {gamma}}{sup Z}{sub 3} interference term exceed the precision of previous ZEUS measurements. The uncertainties of the Parton Density Functions (PDFs) for the gluon and the u-valence quark are expected to be reduced at high-x values when the presented results are included in the PDF fits of the proton. A study is presented to further reduce PDF uncertainties for the gluon at very high x (above 10{sup -1}) through the inclusion of DIS dijet cross sections in a ZEUS-JETS-like PDF fit. An irradiation facility to study the X-ray-induced radiation damage of silicon sensors for the European XFEL was set up at HASYLAB. Nine gate-controlled diodes were irradiated with doses from 1 kGy to 1 GGy in several irradiation steps and the surface current I

  13. Multi-wavelength speckle reduction for laser pico-projectors using diffractive optics

    Science.gov (United States)

    Thomas, Weston H.

    Personal electronic devices, such as cell phones and tablets, continue to decrease in size while the number of features and add-ons keep increasing. One particular feature of great interest is an integrated projector system. Laser pico-projectors have been considered, but the technology has not been developed enough to warrant integration. With new advancements in diode technology and MEMS devices, laser-based projection is currently being advanced for pico-projectors. A primary problem encountered when using a pico-projector is coherent interference known as speckle. Laser speckle can lead to eye irritation and headaches after prolonged viewing. Diffractive optical elements known as diffusers have been examined as a means to lower speckle contrast. Diffusers are often rotated to achieve temporal averaging of the spatial phase pattern provided by diffuser surface. While diffusers are unable to completely eliminate speckle, they can be utilized to decrease the resultant contrast to provide a more visually acceptable image. This dissertation measures the reduction in speckle contrast achievable through the use of diffractive diffusers. A theoretical Fourier optics model is used to provide the diffuser's stationary and in-motion performance in terms of the resultant contrast level. Contrast measurements of two diffractive diffusers are calculated theoretically and compared with experimental results. In addition, a novel binary diffuser design based on Hadamard matrices will be presented. Using two static in-line Hadamard diffusers eliminates the need for rotation or vibration of the diffuser for temporal averaging. Two Hadamard diffusers were fabricated and contrast values were subsequently measured, showing good agreement with theory and simulated values. Monochromatic speckle contrast values of 0.40 were achieved using the Hadamard diffusers. Finally, color laser projection devices require the use of red, green, and blue laser sources; therefore, using a

  14. Beam diagnostics for low energy beams

    Directory of Open Access Journals (Sweden)

    J. Harasimowicz

    2012-12-01

    Full Text Available Low-energetic ion and antimatter beams are very attractive for a number of fundamental studies. The diagnostics of such beams, however, is a challenge due to low currents down to only a few thousands of particles per second and significant fraction of energy loss in matter at keV beam energies. A modular set of particle detectors has been developed to suit the particular beam diagnostic needs of the ultralow-energy storage ring (USR at the future facility for low-energy antiproton and ion research, accommodating very low beam intensities at energies down to 20 keV. The detectors include beam-profile monitors based on scintillating screens and secondary electron emission, sensitive Faraday cups for absolute intensity measurements, and capacitive pickups for beam position monitoring. In this paper, the design of all detectors is presented in detail and results from beam measurements are shown. The resolution limits of all detectors are described and options for further improvement summarized. Whilst initially developed for the USR, the instrumentation described in this paper is also well suited for use in other low-intensity, low-energy accelerators, storage rings, and beam lines.

  15. A discrete element model of laser beam induced current (LBIC) due to the lateral photovoltaic effect in open-circuit HgCdTe photodiodes

    Energy Technology Data Exchange (ETDEWEB)

    Fynn, K.A.; Faraone, L. [Univ. of Western Australia, Nedlands (Australia). Dept. of Electrical and Electronic Engineering; Bajaj, J. [Rockwell International Science Center, Thousand Oaks, CA (United States)

    1995-10-01

    The non-destructive optical characterization technique of Laser-Beam-Induced-Current (LBIC) imaging has proven useful in qualitatively assessing electrically active defects and localized non-uniformities in HgCdTe materials and devices used for infrared photovoltaic arrays. To further the development of a quantitative working model for LBIC, this paper focuses on the application of the technique to photovoltaic structures that are represented by a discrete element equivalent circuit. For this particular case the LBIC signal arises due to the lateral photovoltaic effect in non-uniformly illuminated open-circuit photodiodes. The outcomes of the model predict all of the experimentally observed geometrical features of the LBIC image and signal. Furthermore, the model indicates that the LBIC signal has an extremely weak dependence on the p-n junction reverse saturation current, and shows a linear dependence with laser power. This latter feature may be useful for non-contact measurement of the quantum efficiency of individual photodiodes within a large two-dimensional focal plane array. The decay of the LBIC signal outside the physical boundary of the p-n junction is of the same form as the roll-off in the short circuit photoresponse and, therefore, can be used to extract the diffusion length of minority carriers. Experimental data are obtained from an arsenic implanted p-on-n junction fabricated on MBE grown Hg{sub 1{minus}x}Cd{sub x}Te material with an x-value of 0.3. The p-on-n diode is shown to be uniform and of high quality with an R{sub o}A product of 1 {times} 10{sup 8} {Omega}{center_dot}cm{sup 2} at 77 K. The validity of the simple model developed in this paper, is confirmed by the excellent agreement with experimental results. Consequently, the LBIC technique is shown to be an appropriate diagnostic tool for non-contact quantitative analysis of semiconductor materials and devices.

  16. Modulation of auroral electrojet currents using dual modulated HF beams with ELF phase offset, a potential D-region ionospheric diagnostic

    Science.gov (United States)

    GołKowski, M.; Cohen, M. B.; Moore, R. C.

    2013-05-01

    Experiments at the ionospheric heating facility of the High Frequency Active Auroral Research Program (HAARP) are performed employing dual HF beams amplitude modulated at ELF/VLF with a phase offset between the two modulation waveforms. The amplitude of the observed ELF/VLF waves is strongly dependent on the imposed ELF/VLF phase offset, the modulation waveform, and the orientation of the HF beams. Data from two ground stations are interpreted using simulations of modulated heating power envelopes as well as a comprehensive model of ionospheric ELF/VLF generation. It is found that two colocated vertical beams HF beams excite a single ionospheric ELF/VLF source, but independent ELF/VLF sources can be induced in the ionospheric region above the heater if the HF beams are offset from zenith to intersect at their 3 dB points. Furthermore, the use of two vertical HF beams with ELF phase offset is found to be a potential diagnostic method for the ionospheric D region.

  17. TEBPP: Theoretical and Experimental study of Beam-Plasma-Physics

    Science.gov (United States)

    Anderson, H. R.; Bernstein, W.; Linson, L. M.; Papadopoulos, K.; Kellogg, P. J.; Szuszczewicz, E. P.; Hallinan, T. J.; Leinbach, H.

    1980-01-01

    The interaction of an electron beam (0 to 10 keV, 0 to 1.5 Amp) with the plasma and neutral atmospheres at 200 to 400 km altitude is studied with emphasis on applications to near Earth and cosmical plasmas. The interaction occurs in four space time regions: (1) near electron gun, beam coming into equilibrium with medium; (2) equilibrium propagation in ionosphere; (3) ahead of beam pulse, temporal and spatial precursors; (4) behind a beam pulse. While region 2 is of the greatest interest, it is essential to study Region 1 because it determines the characteristics of the beam as it enters 2 through 4.

  18. The NIKA instrument: results and perspectives towards a permanent KID based camera for the Pico Veleta observatory

    CERN Document Server

    D'Addabbo, A; Adane, A; Ade, P; André, P; Beelen, A; Belier, B; Benoit, A; Bideaud, A; Billot, N; Bourrion, O; Calvo, M; Catalano, A; Coiffard, G; Comis, B; Désert, F -X; Doyle, S; Goupy, J; Kramer, C; Leclercq, S; Macias-Perez, J; Martino, J; Mauskopf, P; Mayet, F; Monfardini, A; Pajot, F; Pascale, E; Ponthieu, N; Revéret, V; Rodriguez, L; Savini, G; Schuster, K F; Sievers, A; Tucker, C; Zylka, R

    2013-01-01

    The New IRAM KIDs Array (NIKA) is a pathfinder instrument devoted to millimetric astronomy. In 2009 it was the first multiplexed KID camera on the sky; currently it is installed at the focal plane of the IRAM 30-meters telescope at Pico Veleta (Spain). We present preliminary data from the last observational run and the ongoing developments devoted to the next NIKA-2 kilopixels camera, to be commissioned in 2015. We also report on the latest laboratory measurements, and recent improvements in detector cosmetics and read-out electronics. Furthermore, we describe a new acquisition strategy allowing us to improve the photometric accuracy, and the related automatic tuning procedure.

  19. Laser beam shaping theory and techniques

    CERN Document Server

    Dickey, Fred M

    2000-01-01

    The mathematical and physical theory of lossless beam shaping; Gaussian beam shaping - diffraction theory and design; geometrical methods; optimization-based techniques for laser shaping optics; beam shaping with diffractive diffusers; multi-aperture beam integration systems; classical (non-laser) methods; current technology of beam profile measurements.

  20. "How like an Angel": Self-Fashioning in Pico della Mirandola and Raphael

    NARCIS (Netherlands)

    Rijser, D.; Rijser, D.; Treffers, B.

    2009-01-01

    The projected image of the philosopher Pico della Mirandola and the painter Raphael share a common trait: both were seen by contemporaries as angels. The role Pico and Raphael themselves played in the establishment of this assimilation is discussed, as is the theological and intellectual background

  1. "How like an Angel": Self-Fashioning in Pico della Mirandola and Raphael

    NARCIS (Netherlands)

    Rijser, D.; Rijser, D.; Treffers, B.

    2009-01-01

    The projected image of the philosopher Pico della Mirandola and the painter Raphael share a common trait: both were seen by contemporaries as angels. The role Pico and Raphael themselves played in the establishment of this assimilation is discussed, as is the theological and intellectual background

  2. Altered beta-adrenergic receptor-stimulated cAMP formation in cultured skin fibroblasts from Alzheimer donors.

    Science.gov (United States)

    Huang, H M; Gibson, G E

    1993-07-15

    An alteration in signal transduction systems in Alzheimer's disease would likely be of pathophysiological significance, because these steps are critical to normal brain function. Since dynamic processes are difficult to study in autopsied brain, the current studies utilized cultured skin fibroblasts. The beta-adrenergic-stimulated increase in cAMP was reduced approximately 80% in fibroblasts from Alzheimer's disease compared with age-matched controls. The deficit in Alzheimer fibroblasts in response to various adrenergic agonists paralleled their beta-adrenergic potency, and enhancement of cAMP accumulation by a non-adrenergic agonist, such as prostaglandin E1, was similar in Alzheimer and control fibroblasts. Diminished adenylate cyclase activity did not underlie these abnormalities, since direct stimulation of adenylate cyclase by forskolin elevated cAMP production equally in Alzheimer and control fibroblasts. Cholera toxin equally stimulated cAMP formation in Alzheimer and control fibroblasts. Moreover, cholera toxin partially reduced isoproterenol-induced cAMP deficit in Alzheimer fibroblasts. Pertussis toxin, on the other hand, did not alter the Alzheimer deficits. The results suggest either that the coupling of the GTP-binding protein(s) to the beta-adrenergic receptor is abnormal or that the sensitivity of receptor is altered with Alzheimer's disease. Further, any hypothesis about Alzheimer's disease must explain why a reduced beta-adrenergic-stimulated cAMP formation persists in tissue culture.

  3. Induction of a Torpor-Like State by 5'-AMP Does Not Depend on H2S Production.

    Directory of Open Access Journals (Sweden)

    George J Dugbartey

    Full Text Available Therapeutic hypothermia is used to reduce ischemia/reperfusion injury (IRI during organ transplantation and major surgery, but does not fully prevent organ injury. Interestingly, hibernating animals undergo repetitive periods of low body temperature called 'torpor' without signs of organ injury. Recently, we identified an essential role of hydrogen sulfide (H2S in entrance into torpor and preservation of kidney integrity during hibernation. A torpor-like state can be induced pharmacologically by injecting 5'-Adenosine monophosphate (5'-AMP. The mechanism by which 5'-AMP leads to the induction of a torpor-like state, and the role of H2S herein, remains to be unraveled. Therefore, we investigated whether induction of a torpor-like state by 5-AMP depends on H2S production.To study the role of H2S on the induction of torpor, amino-oxyacetic acid (AOAA, a non-specific inhibitor of H2S, was administered before injection with 5'-AMP to block endogenous H2S production in Syrian hamster. To assess the role of H2S on maintenance of torpor induced by 5'-AMP, additional animals were injected with AOAA during torpor.During the torpor-like state induced by 5'-AMP, the expression of H2S- synthesizing enzymes in the kidneys and plasma levels of H2S were increased. Blockade of these enzymes inhibited the rise in the plasma level of H2S, but neither precluded torpor nor induced arousal. Remarkably, blockade of endogenous H2S production was associated with increased renal injury.Induction of a torpor-like state by 5'-AMP does not depend on H2S, although production of H2S seems to attenuate renal injury. Unraveling the mechanisms by which 5'-AMP reduces the metabolism without organ injury may allow optimization of current strategies to limit (hypothermic IRI and improve outcome following organ transplantation, major cardiac and brain surgery.

  4. Induction of a Torpor-Like State by 5'-AMP Does Not Depend on H2S Production.

    Science.gov (United States)

    Dugbartey, George J; Bouma, Hjalmar R; Strijkstra, Arjen M; Boerema, Ate S; Henning, Robert H

    2015-01-01

    Therapeutic hypothermia is used to reduce ischemia/reperfusion injury (IRI) during organ transplantation and major surgery, but does not fully prevent organ injury. Interestingly, hibernating animals undergo repetitive periods of low body temperature called 'torpor' without signs of organ injury. Recently, we identified an essential role of hydrogen sulfide (H2S) in entrance into torpor and preservation of kidney integrity during hibernation. A torpor-like state can be induced pharmacologically by injecting 5'-Adenosine monophosphate (5'-AMP). The mechanism by which 5'-AMP leads to the induction of a torpor-like state, and the role of H2S herein, remains to be unraveled. Therefore, we investigated whether induction of a torpor-like state by 5-AMP depends on H2S production. To study the role of H2S on the induction of torpor, amino-oxyacetic acid (AOAA), a non-specific inhibitor of H2S, was administered before injection with 5'-AMP to block endogenous H2S production in Syrian hamster. To assess the role of H2S on maintenance of torpor induced by 5'-AMP, additional animals were injected with AOAA during torpor. During the torpor-like state induced by 5'-AMP, the expression of H2S- synthesizing enzymes in the kidneys and plasma levels of H2S were increased. Blockade of these enzymes inhibited the rise in the plasma level of H2S, but neither precluded torpor nor induced arousal. Remarkably, blockade of endogenous H2S production was associated with increased renal injury. Induction of a torpor-like state by 5'-AMP does not depend on H2S, although production of H2S seems to attenuate renal injury. Unraveling the mechanisms by which 5'-AMP reduces the metabolism without organ injury may allow optimization of current strategies to limit (hypothermic) IRI and improve outcome following organ transplantation, major cardiac and brain surgery.

  5. A lusofonia na Wikipédia em 150 tópicos

    Directory of Open Access Journals (Sweden)

    Cláudia Freitas

    2012-04-01

    Full Text Available Este artigo descreve os tópicos usados no Págico, a primeira avaliação conjunta em recolha de informação centrada em tópicos relacionados com a lusofonia, usando o material da Wikipédia em português. Depois de uma explicação sobre como os tópicos foram escolhidos e de questões associadas à sua escolha e à sua categorização posterior, os tópicos são apresentados por categoria. Comentamos também a forma de apresentação de certas informações na Wikipédia e, por fim, fazemos uma categorização geográfica e temporal dos tópicos.

  6. Vertical Profile of Aerosol Properties at Pico Mountain, Azores

    Science.gov (United States)

    Wright, K.; Mazzoleni, C.; Mazzoleni, L. R.; Dzepina, K.; Hueber, J.; China, S.; Sharma, N.

    2013-12-01

    Pico Mountain (2325m asl) is a dormant volcano in the archipelago of the Azores1500 km west of Lisbon, Portugal in the North Atlantic. It differs from typical mountain ranges such as the Alps or the Rockies, which are large and present a complex orography. Pico Mountain has a simple cone-like structure with only one main peak and is thousands of kilometers away from any other significant mountain range. In summer months, it is typical for air masses to move around the mountain rather than traveling up its face. This implies that often the peak of the mountain lies above the marine boundary layer in the free troposphere, while the lower part of the mountain is affected by marine clouds and marine air-masses. An atmospheric monitoring station, the Pico Mountain Observatory was established in 2001 in the summit caldera of the volcano at 2225m above sea level. The observatory is far from large populations or pollution sources, which makes the station ideal to study atmospheric gases and aerosols transported over long-ranges in the free troposphere. The station is reachable only by foot following a steep and strenuous hiking trail. In the summer of 2013 we began to collect vertical profiles of aerosol by carrying an instrumented backpack up to the summit of the mountain, with the goal of studying the vertical structure of atmospheric aerosols from the marine boundary layer to the free troposphere. The backpack was carried from the base of trail at 1200m asl. The backpack was equipped with the following instruments: 1. Nephelometer to measure light scattering from aerosol 2. 2-size optical particle counter (300-500 nm) 3. Portable micro-aethalometer to measure absorbing aerosols 4. SEM/TEM sampler to collect particles for off-line electron microscopy analysis 5. Battery powered data logger to measure relative humidity, temperature and pressure 6. GPS tracking device We provide a preliminary analysis of data collected in 2013 to gain insight on the vertical distribution

  7. Cyclic-AMP regulates postnatal development of neural and behavioral responses to NaCl in rats

    Science.gov (United States)

    Qian, Jie; Mummalaneni, Shobha; Phan, Tam-Hao T.; Heck, Gerard L.; DeSimone, John A.; West, David; Mahavadi, Sunila; Hojati, Deanna; Murthy, Karnam S.; Rhyu, Mee-Ra; Spielman, Andrew I.; Özdener, Mehmet Hakan

    2017-01-01

    During postnatal development rats demonstrate an age-dependent increase in NaCl chorda tympani (CT) responses and the number of functional apical amiloride-sensitive epithelial Na+ channels (ENaCs) in salt sensing fungiform (FF) taste receptor cells (TRCs). Currently, the intracellular signals that regulate the postnatal development of salt taste have not been identified. We investigated the effect of cAMP, a downstream signal for arginine vasopressin (AVP) action, on the postnatal development of NaCl responses in 19–23 day old rats. ENaC-dependent NaCl CT responses were monitored after lingual application of 8-chlorophenylthio-cAMP (8-CPT-cAMP) under open-circuit conditions and under ±60 mV lingual voltage clamp. Behavioral responses were tested using 2 bottle/24h NaCl preference tests. The effect of [deamino-Cys1, D-Arg8]-vasopressin (dDAVP, a specific V2R agonist) was investigated on ENaC subunit trafficking in rat FF TRCs and on cAMP generation in cultured adult human FF taste cells (HBO cells). Our results show that in 19–23 day old rats, the ENaC-dependent maximum NaCl CT response was a saturating sigmoidal function of 8-CPT-cAMP concentration. 8-CPT-cAMP increased the voltage-sensitivity of the NaCl CT response and the apical Na+ response conductance. Intravenous injections of dDAVP increased ENaC expression and γ-ENaC trafficking from cytosolic compartment to the apical compartment in rat FF TRCs. In HBO cells dDAVP increased intracellular cAMP and cAMP increased trafficking of γ- and δ-ENaC from cytosolic compartment to the apical compartment 10 min post-cAMP treatment. Control 19–23 day old rats were indifferent to NaCl, but showed clear preference for appetitive NaCl concentrations after 8-CPT-cAMP treatment. Relative to adult rats, 14 day old rats demonstrated significantly less V2R antibody binding in circumvallate TRCs. We conclude that an age-dependent increase in V2R expression produces an AVP-induced incremental increase in cAMP that

  8. Radioprotection of the rat parotid gland by cAMP

    Energy Technology Data Exchange (ETDEWEB)

    Sodicoff, M.; Conger, A.D.

    1983-10-01

    Most earlier studies showing a radioprotective effect by cAMP show only slight degrees of protection. The present study demonstrates a substantial protective effect (DMF, 1.63) of exogenously administered cAMP on the rat parotid gland and supports the mechanism suggested previously for protection afforded the parotid glands by the ..beta..-adrenergic agonist isoproterenol, which is known to elevate endogenous intracellular cAMP.

  9. Pico Reentry Probes: Affordable Options for Reentry Measurements and Testing

    Science.gov (United States)

    Ailor, William H.; Kapoor, Vinod B.; Allen, Gay A., Jr.; Venkatapathy, Ethiraj; Arnold, James O.; Rasky, Daniel J.

    2005-01-01

    It is generally very costly to perform in-space and atmospheric entry experiments. This paper presents a new platform - the Pico Reentry Probe (PREP) - that we believe will make targeted flight-tests and planetary atmospheric probe science missions considerably more affordable. Small, lightweight, self-contained, it is designed as a "launch and forget" system, suitable for experiments that require no ongoing communication with the ground. It contains a data recorder, battery, transmitter, and user-customized instrumentation. Data recorded during reentry or space operations is returned at end-of-mission via transmission to Iridium satellites (in the case of earth-based operations) or a similar orbiting communication system for planetary missions. This paper discusses possible applications of this concept for Earth and Martian atmospheric entry science. Two well-known heritage aerodynamic shapes are considered as candidates for PREP: the shape developed for the Planetary Atmospheric Experiment Test (PAET) and that for the Deep Space II Mars Probe.

  10. superar por el pensamiento antrópico

    Directory of Open Access Journals (Sweden)

    José Ricardo Perfecto Sanchez

    2008-01-01

    Full Text Available Hoy en día se habla mucho de calidad académica, posiblemente como consecuencia del impulso a la calidad industrial, una de las características de un mundo globalizado y en donde aparece la competitividad como signo de progreso social. Sin embargo, la calidad académica, además de la modernización tecnológica en el proceso de enseñanzaaprendizaje, requiere de una revaloración del ser humano, que aspira a satisfacer necesidades, no sólo físicas y biológicas, sino también, espirituales, por parte de sus sentimientos, conocimientos y voliciones, que trascienden lo inmediato, lo empírico y temporal. Para alcanzar esto se propone la necesidad de afrontar el reto de superar una apariencia de calidad aducativa, asumiendo con responsabilidad y libertad el pensamiento antrópico.

  11. Temperature calibration of Pico-Rad detectors for radon measurement.

    Science.gov (United States)

    Bem, H; Bem, E M; Chruścielewski, W; Skalski, H

    2000-01-01

    A simple mathematical equation linking the activity of adsorbed radon in the vials to the time and temperature of its exposure is discussed. The calibration coefficient--Ks, defined as activity measured in cpm after saturation time, corresponding to radon air concentration of 1 Bq m-3, was determined for four temperatures: 284, 291, 294 and 298 K. A linear relationship of ln Ks values versus T-1 was found. The relatively high difference in Ks values: 2.12 and 1.24 cpm/Bq m-3 for the temperatures of 284 and 298 K, respectively, was observed. It indicates that temperature fluctuations during Pico-Rad vial exposure may lead to erroneous results if the constant average temperature of exposure is introduced into a commonly used computer programme for calculating Rn concentration.

  12. Temperature calibration of PICO-RAD detectors for radon measurement

    Energy Technology Data Exchange (ETDEWEB)

    Bem, H.; Bem, E.M.; Chruscielewski, W.; Skalski, H. [Politechnika Lodzka, Lodz (Poland)

    1996-10-01

    A simple mathematical equation linking the activity of adsorbed radon in the vials to the time of its exposure has been discussed. The calibration coefficient K{sub s}, defined as a measured activity in cpm after a saturation time, corresponding to a radon air concentration of 1 Bq m{sup -3} has been determined for four temperatures: 284, 291, 294 and 298 K. A linear relationship of ln K{sub s} values versus T{sup -1} has been found. The relatively high difference in K{sub s} values: 2.12 and 1.24 cpm/Bq m{sup 3} for the temperatures of 284 and 298 K, respectively, was observed. It indicates that temperature fluctuations during Pico-Rad vial exposure may lead to erroneous results if the constant average temperature of exposure is introduced into a commonly used computer program for calculating Rn concentration. (author). 6 refs, 4 figs.

  13. Calibration of PICO Bubble Chamber Dark Matter Detectors

    Science.gov (United States)

    Jin, Miaotianzi; PICO Collaboration

    2016-03-01

    The PICO Collaboration builds bubble chambers for the direct detection of WIMP dark matter. I will present the suite of calibration experiments performed to measure the sensitivity of these chambers to nuclear recoils (the expected WIMP signal) and to gamma rays (a common background to the WIMP signal). These calibrations include measurements with a 10-ml C3F8 bubble chamber at Northwestern University and with a 30-ml C3F8 bubble chamber deployed in the University of Montreal's tandem Van de Graaf facility, giving the bubble chamber response to a variety of gamma rays, broad-spectrum neutron sources, and mono-energetic low energy neutrons. I will compare our measured sensitivities to those predicted by a simple thermodynamic model and will show how the results impact our ability to detect dark matter, with a focus on light WIMP searches. Supported by DOE Grant: DE-SC0012161.

  14. Hallazgo endoscópico de linfoma folicular primario

    Directory of Open Access Journals (Sweden)

    Diana L. Franco

    2015-03-01

    Full Text Available Una mujer de 79 años, sin antecedentes patológicos de importancia, consultó al servicio de gastro-enterología por síntomas de dispepsia de larga data. Se practicó una esofagogastroduodenoscopia en la que se observó mucosa nodular en la segunda porción del duodeno. Esta morfología y los hallazgos inmunofenotípicos eran indicativos de linfoma folicular de bajo grado. El propósito de este manuscrito es ilustrar al lector sobre esta inusual condición en el duodeno, la cual es patognomónica de linfoma.

  15. MANEJO LAPAROSCÓPICO DE MASAS ANEXIALES: EXPERIENCIA LOCAL

    OpenAIRE

    Catalán B.,Alejandra; Laiz R.,Domingo; Corvalán A,Jaime; Masoli I.,Diego; Vásquez C.,Wladimir

    2005-01-01

    Se analizaron 132 pacientes evaluando características epidemiológicas y clínicas, la correlación entre ecografía y anatomía patológica, la evolución y el uso laparoscópico en el tratamiento de masas anexiales. El diagnóstico se basó en la identificación ecográfica de una masa anexial. El rango de edad fue 16-66 años. El dolor abdominal y pélvico estuvo presente en 34% de los casos; en 45% se diagnosticó la masa anexial por examen ecográfico de rutina. En 53% de las pacientes se realizó quiste...

  16. AmpC酶的研究进展

    Institute of Scientific and Technical Information of China (English)

    周志慧

    2001-01-01

    近年来研究表明,革兰阴性杆菌不仅产生染色体介导的AmpC酶,而且还产生质粒介导的AmpC酶,导致耐药性的广泛传播,引起了临床治疗的困难.本文就AmpC酶的诱导机制、检测及产AmpC酶菌株感染的治疗等研究进展进行综述.

  17. Amp C酶及其耐药性

    Institute of Scientific and Technical Information of China (English)

    赵虎; 孔宪涛

    2002-01-01

    本文叙述了Amp C酶的定义、Amp C酶的基因结构与功能、Amp C酶的合成、Amp C酶的耐药性及其耐药机制,以及Amp C酶的检测方法。Amp C酶是由肠杆菌科细菌和铜绿假单胞菌等产生的一类头孢菌素酶,可水解头孢菌素类抗生素,导致细菌对这类抗生素产生耐药性。编码产生Amp C酶的基因包括结构基因-amp C和四种调控基因-ampR、ampD、ampE以及ampG,但其具体的转录、调控机制目前尚未完全明了。Amp C酶的合成具有明显的诱导性,其诱导有菌种依赖性、抗生素依赖性和生长条件依赖性。Amp C酶的耐药机制主要是作用于头胞菌素的β-内酰胺环上的羰基,形成酰化酶中间体,然后在水分子的作用下导致β-内酰胺环开环而失活。大部分Amp C酶都是由细菌染色体所介导,但近年来陆续在质粒上发现这些基因,并在肺炎克雷伯菌、大肠埃希菌、产气肠杆菌和沙门菌中持续高水平的表达,还可以通过质粒在细菌间相互传播,导致耐药菌的广泛传播。产Amp C酶菌株的检测以改良的酶提取物三维试验法较佳。

  18. Optimizing the electron beam parameters for head-on beam-beam compensation in RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Y.; Fischer, W.; Pikin, A.; Gu, X.

    2011-03-28

    Head-on beam-beam compensation is adopted to compensate the large beam-beam tune spread from the protonproton interactions at IP6 and IP8 in the Relativistic Heavy Ion Collider (RHIC). Two e-lenses are being built and to be in stalled near IP10 in the end of 2011. In this article we perform numeric simulation to investigate the effect of the electron beam parameters on the proton dynamics. The electron beam parameters include its transverse profile, size, current, offset and random errors in them. In this article we studied the effect of the electron beam parameters on the proton dynamics. The electron beam parameters include its transverse shape, size, current, offset and their random errors. From the study, we require that the electron beam size can not be smaller than the proton beam's. And the random noise in the electron current should be better than 0.1%. The offset of electron beam w.r.t. the proton beam center is crucial to head-on beam-beam compensation. Its random errors should be below {+-}8{micro}m.

  19. Analgésicos tópicos

    Directory of Open Access Journals (Sweden)

    Murilo Pereira Flores

    2012-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O tratamento da dor envolve a utilização de analgésicos opioides, analgésicos comuns, anti-inflamatórios não hormonais (AINH's e analgésicos adjuvantes. Tradicionalmente, estes fármacos são administrados por via sistêmica ou no neuroeixo. Entretanto, quando aplicados por estas vias, estão associados a efeitos colaterais importantes, os quais podem inviabilizar o seu uso. A administração tópica de analgésicos é uma alternativa. O objetivo deste trabalho é discutir os analgésicos tópicos, seus mecanismos de ação e eficácia clínica. CONTEÚDO: Trata-se de um trabalho de revisão que aborda a utilização tópica de anestésicos locais, capsaicina, clonidina, antidepressivos tricíclicos, cetamina, opioides e canabinoides, discutindo o seu mecanismo de ação e a sua eficácia. CONCLUSÕES: Os analgésicos tópicos são promissores como estratégia para o tratamento da dor, já que estão associados à menor incidência de efeitos colaterais. O benefício dos anestésicos locais, dos AINH's e da capsaicina está bem estabelecido, entretanto, a eficácia de clonidina, antidepressivos tricíclicos, cetamina, opioides e canabinoides ainda é questionável. Trabalhos demonstram que a abordagem multimodal é uma alternativa, porém estudos são necessários para confirmar esta hipótese.

  20. Tratamento Videolaparoscópico de Endometriomas Ovarianos

    Directory of Open Access Journals (Sweden)

    Lopez Adriana C.S.

    2000-01-01

    Full Text Available Objetivo: avaliar os resultados do tratamento videolaparoscópico de 32 pacientes com endometrioma ovariano. Métodos: estudo retrospectivo que incluiu trinta e duas pacientes encaminhadas ao setor de Endoscopia Ginecológica do Serviço de Ginecologia e Obstetrícia do Hospital do Servidor Público Estadual "Francisco Morato de Oliveira" - São Paulo, as quais tinham diagnóstico clínico e ultra-sonográfico de endometrioma ovariano e foram tratadas por videolaparoscopia. Onze pacientes com endometriomas com diâmetro menor que 3 cm foram submetidas à drenagem do endometrioma e exérese da cápsula na primeira laparoscopia. Vinte e uma pacientes com endometriomas com diâmetros maior que 3 cm foram submetidas à drenagem do endometrioma e lavagem do cisto na primeira laparoscopia. A seguir, utilizaram análogo do GnRH por quatro meses (1 ampola mensal e então foram submetidas à segunda laparoscopia para retirada da cápsula do endometrioma. O exame histopatológico do material obtido na cirurgia foi realizado em todos os casos. Avaliou-se o resultado imediato do procedimento e a freqüência de recidivas. Resultados: não se registraram intercorrências cirúrgicas ou complicações pós-operatórias. Ocorreram três recidivas em um período de seis a doze meses, todas no grupo de 21 pacientes com endometriomas com o diâmetro maior que 3 cm. Conclusão: o tratamento videolaparoscópico dos endometriomas ovarianos com retirada da cápsula apresenta bons resultados e baixo índice de recidiva.