Sample records for physiological society 16-17

  1. European AIDS Clinical Society Second Standard of Care Meeting, Brussels 16-17 November 2016

    DEFF Research Database (Denmark)

    De Wit, S; Battegay, M; D'Arminio Monforte, A


    The European AIDS Clinical Society (EACS) organized a second meeting on Standard of Care in Europe on November 16-17 th, 2016. The aims of the meeting were to discuss and propose actions on three topics, namely: Adherence to guidelines for treatment initiation, treatment monitoring and outcomes, ...

  2. Scientific discussion | Unifying physics and technology in light of Maxwell's equations | Royal Society, London | 16-17 November

    CERN Multimedia


    Discussion meeting organised by Professor Anatoly Zayats, Professor John Ellis and Professor Roy Pike.   16-17 November 2015 at The Royal Society 6-9 Carlton House Terrace, London Event details The unification of electric and magnetic fields about 150 years ago in what is now known as electromagnetic theory expressed in Maxwell's Equations has enabled virtually all modern electrical, electronic, radio and photonic technologies. What new scientific breakthroughs and applications will unification with the other fields provide? This meeting brings together high-energy, optical, quantum and solid-state physicists to discuss recent developments enabled by Maxwell's Equations and will try to predict future innovations. Attending this event This event is intended for researchers in relevant fields and is free to attend. There are a limited number of places and registration is essential. For more information, visit the Royal Society event website.

  3. 16,17-Seco- and 2,3:16,17-di-seco-pregnanes from Guarea guidonia

    Energy Technology Data Exchange (ETDEWEB)

    Garcez, Walmir Silvan; Garcez, Fernanda Rodrigues [Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, MS (Brazil). Dept. de Quimica]. E-mail:; Soares, Luzinatia Ramos [Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, MS (Brazil). Dept. de Quimica; Universidade Estadual de Mato Grosso do Sul, Campo Grande, MS (Brazil)


    Two new seco- and di-seco-pregnanes, 2{alpha},3{beta}-dihydroxy-16,17-seco-pregn-17-ene-16-oic acid methyl ester 2{beta},19-hemiketal (1) and 2,3:16,17-di-seco-pregn-17-ene-3-oic acid-16-oic acid methyl ester-19-hydroxy-2-carboxylic acid-2,19-lactone (2), have been obtained from the trunk bark of Guarea guidonia. Their structures have been established by a combination of 1D- and 2D-NMR spectroscopic techniques and MS data. The unique seco- and di-seco-pregnane carbocyclic skeletal types as found in compounds 1 and 2 are being reported in the Meliaceae for the first time as well as the occurrence of pregnanes in the genus Guarea. (author)

  4. Recognition of American Physiological Society Members Whose Research Publications Had a Significant Impact on the Discipline of Physiology (United States)

    Tipton, Charles M.


    Society members whose research publication during the past 125 yr had an important impact on the discipline of physiology were featured at the American Physiological Society (APS)'s 125th Anniversary symposium. The daunting and challenging task of identifying and selecting significant publications was assumed by the Steering Committee of the…

  5. 16 CFR 309.17 - Labels. (United States)


    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Labels. 309.17 Section 309.17 Commercial... ALTERNATIVE FUELS AND ALTERNATIVE FUELED VEHICLES Requirements for Alternative Fuels Label Specifications § 309.17 Labels. All labels must meet the following specifications: (a) Layout: (1) Non-liquid...

  6. 16 CFR 500.17 - Fractions. (United States)


    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Fractions. 500.17 Section 500.17 Commercial... LABELING ACT § 500.17 Fractions. (a) SI metric declarations of net quantity of contents of any consumer commodity may contain only decimal fractions. Other declarations of net quantity of contents may contain...

  7. Native American Games & European Religious Attitudes in the 16th & 17th Centuries. (United States)

    Eisen, George

    Some aspects of the white-Indian relationship are reflected in the writings of 16th and 17th century observers of Indian pastimes. The Noble Savage image was apparently accepted by French colonists as a consequence of an intellectual disappointment in the contemporary societies. In an age of absolutism and religious intolerance, the picture of the…

  8. Synthesis of some 16,17-secoandrost-5-ene derivatives

    Directory of Open Access Journals (Sweden)

    Gaković Andrea R.


    Full Text Available Starting from 3β-acetoxy-17-oxo-16,17-secoandrost-5-ene-16-nitrile (1, 3β-acetoxy-16,17-secoandrost-5-ene-16-nitrile (4 was synthesized by a three-stage procedure. First, the formyl group of compound 1 was reduced, to yield the alcohol 2. Compound 2 was further transformed to the mesyloxy derivative 3, whose reduction with NaBH3CN gave compound 4. Apart from compound 4 as the main reaction product, two additional products were obtained, for which the GC/MS analysis suggested that they are 8(14 and 14 derivatives of compound 4. Compound 4 was transformed into 3β-hydroxy-16,17-sesoandrost-5-ene-16-nitrile (7, the Oppenauer oxidation of which afforded 3-oxo-16,17-secoandrost-4-ene-16-nitrile (8.

  9. 17 CFR 200.735-16 - Delegation. (United States)


    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Delegation. 200.735-16 Section 200.735-16 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT... Former Members and Employees of the Commission § 200.735-16 Delegation. Any official responsibility...

  10. Recognition of American Physiological Society members whose research publications had a significant impact on the discipline of physiology. (United States)

    Tipton, Charles M


    Society members whose research publication during the past 125 yr had an important impact on the discipline of physiology were featured at the American Physiological Society (APS)'s 125th Anniversary symposium. The daunting and challenging task of identifying and selecting significant publications was assumed by the Steering Committee of the History of Physiology Interest Group, who requested recommendations and rationales from all Sections, select Interest Groups, and active senior APS members. The request resulted in recommendations and rationales from nine Sections, one Interest Group, and 28 senior members, identifying 38 publications and 43 members for recognition purposes. The publication recommendations included 5 individuals (Cournand, Erlanger, Gasser, Hubel, and Wiesel) whose research significantly contributed to their selection for the Nobel Prize in Medicine or Physiology, 4 individuals who received multiple recommendations [i.e., Cannon (3), Curran (2), Fenn (3), and Hamilton (2)], and 11 members who had been APS Presidents. Of the recommended articles, 33% were from the American Journal of Physiology, with the earliest being published in 1898 (Cannon) and the latest in 2007 (Sigmund). For the brief oral presentations, the History of Physiology Steering Committee selected the first choices of the Sections or Interest Group, whereas rationales and representation of the membership were used for the presentations by senior members.

  11. Shell model description of 16O(p,γ)17F and 16O(p,p)16O reactions

    International Nuclear Information System (INIS)

    Bennaceur, K.; Michel, N.; Okolowicz, J.; Ploszajczak, M.; Bennaceur, K.; Nowacki, F.; Okolowicz, J.


    We present shell model calculations of both the structure of 17 F and the reactions 16 O(p,γ) 17 F, 16 O(p,p) 16 O. We use the ZBM interaction which provides a fair description of the properties of 16 O and neighbouring nuclei and, in particular it takes account for the complicated correlations in coexisting low-lying states of 16 O. (authors)

  12. 16 CFR 1512.17 - Other requirements. (United States)


    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Other requirements. 1512.17 Section 1512.17 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL HAZARDOUS SUBSTANCES ACT REGULATIONS... the ground plane. (d) Toe clearance. Bicycles not equipped with positive foot-retaining devices (such...

  13. 17 CFR 240.16c-1 - Brokers. (United States)


    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Brokers. 240.16c-1 Section 240... Act of 1934 Exemption of Certain Transactions from Section 16(c) § 240.16c-1 Brokers. Any transaction... a broker of an order for an account in which the broker has no direct or indirect interest. ...

  14. 17 CFR 240.16c-4 - Derivative securities. (United States)


    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Derivative securities. 240.16c-4 Section 240.16c-4 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED... Exchange Act of 1934 Exemption of Certain Transactions from Section 16(c) § 240.16c-4 Derivative securities...

  15. 17 CFR 240.16a-4 - Derivative securities. (United States)


    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Derivative securities. 240.16a....16a-4 Derivative securities. (a) For purposes of section 16 of the Act, both derivative securities and... securities, except that the acquisition or disposition of any derivative security shall be separately...

  16. 17 CFR 240.16b-6 - Derivative securities. (United States)


    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Derivative securities. 240.16b... Exchange Act of 1934 Exemption of Certain Transactions from Section 16(b) § 240.16b-6 Derivative securities...). Note to paragraph (b): The exercise or conversion of a derivative security that does not satisfy the...

  17. 16 CFR 0.17 - Bureau of Consumer Protection. (United States)


    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Bureau of Consumer Protection. 0.17 Section... ORGANIZATION § 0.17 Bureau of Consumer Protection. The Bureau investigates unfair or deceptive acts or..., and international agencies and organizations in consumer protection enforcement and regulatory matters...

  18. 17 CFR 240.16a-6 - Small acquisitions. (United States)


    ... (including securities underlying derivative securities, but excluding acquisitions exempted by rule from... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Small acquisitions. 240.16a-6 Section 240.16a-6 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED...

  19. 17 CFR 240.16a-3 - Reporting transactions and holdings. (United States)


    ... Act, except: (A) Exercises and conversions of derivative securities exempt under either § 240.16b-3 or... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Reporting transactions and holdings. 240.16a-3 Section 240.16a-3 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION...

  20. Determination of allowable ramp power levels to maintain the mechanical integrity for 14x14, 16x16 and 17x17 KOFAs

    International Nuclear Information System (INIS)

    Lee, Chan Bok; Kim, Ki Hang; Kim, Kyu Tae


    Transient behavior of the fuel rods with various rod power histories for 17x17 KOFA fuels has been calculated and evaluated, and sensitivity analyses of the key parameters such as rod power history before ramp, fast neutron flux and cycle length have also been performed. Results show that cladding strain is more limiting in determining the allowable ramp power level than fuel centerline temperature, and neutron flux has greatest influence on fuel transient behavior among rod power history before ramp, fast neutron flux and cycle length. Based upon the above results, allowable ramp power levels versus burnup for 14x14, 16x16 and 17x17 KOFA fuels were determined for the rods with different initial power levels of F xy = 0.6, 0.8, 1.0 and 1.2, which shows that the rod with lower initial power level gives lower allowable ramp power level. It can be said, therefore, that if the ramp power level of the rod at certain initial power level and burnup is less than the corresponding allowable ramp power level, the transient behavior of the rod satisfy the fuel rod design criteria. (Author)

  1. ESNA: European Society for New Methods in Agricultural Research. 23. annual meeting and 3. German meeting on food irradiation. Book of abstracts

    International Nuclear Information System (INIS)


    The book comprises 181 abstracts of the 23rd Annual Meeting of the European Society for New Methods in Agricultural Research and the 3rd German Meeting on Food Irradiation. The following subjects were discussed in six workshops: Radiation Technology and 3rd German Meeting on Food Irradiation (44); Advanced Methods in Animal Sciences (17); Soil-Plant Relationships (36); Plant Genetics, Breeding and Physiology (48); Environmental Aspects and Energy Use (16); Pest Management (20). The abstracts are supplemented by an alphabetic index of authors. (UHE) [de

  2. Coupled-channel calculation for cross section of fusion and barrier distribution of {}^{16,17,18}O + {}^{16}O reactions (United States)

    Fereidonnejad, R.; Sadeghi, H.; Ghambari, M.


    In this work, the effect of multi-phonon excitation on heavy-ion fusion reactions has been studied and fusion barrier distributions of energy intervals near and below the Coulomb barrier have been studied for 16,17,18O + 16O reactions. The structure and deformation of nuclear projectiles have been studied. Given the adaptation of computations to experimental data, our calculations predict the behavior of reactions in intervals of energy in which experimental measurements are not available. In addition the S-factor for these reactions has been calculated. The results showed that the structure and deformation of a nuclear projectile are important factors. The S-factor, obtained in the coupled-channel calculations for the {}^{16}O + {}^{16}O, {}^{17}O +{}^{16}O and {}^{18}O +{}^{16}O reactions, showed good agreement with the experimental data and had a maximum value at an energy near 5, 4.5 and 4 MeV, respectively.

  3. Space Physiology within an Exercise Physiology Curriculum (United States)

    Carter, Jason R.; West, John B.


    Compare and contrast strategies remain common pedagogical practices within physiological education. With the support of an American Physiological Society Teaching Career Enhancement Award, we have developed a junior- or senior-level undergraduate curriculum for exercise physiology that compares and contrasts the physiological adaptations of…

  4. Biphasic voltage-dependent inactivation of human NaV 1.3, 1.6 and 1.7 Na+ channels expressed in rodent insulin-secreting cells. (United States)

    Godazgar, Mahdieh; Zhang, Quan; Chibalina, Margarita V; Rorsman, Patrik


    Na + current inactivation is biphasic in insulin-secreting cells, proceeding with two voltage dependences that are half-maximal at ∼-100 mV and -60 mV. Inactivation of voltage-gated Na + (Na V ) channels occurs at ∼30 mV more negative voltages in insulin-secreting Ins1 and primary β-cells than in HEK, CHO or glucagon-secreting αTC1-6 cells. The difference in inactivation between Ins1 and non-β-cells persists in the inside-out patch configuration, discounting an involvement of a diffusible factor. In Ins1 cells and primary β-cells, but not in HEK cells, inactivation of a single Na V subtype is biphasic and follows two voltage dependences separated by 30-40 mV. We propose that Na V channels adopt different inactivation behaviours depending on the local membrane environment. Pancreatic β-cells are equipped with voltage-gated Na + channels that undergo biphasic voltage-dependent steady-state inactivation. A small Na + current component (10-15%) inactivates over physiological membrane potentials and contributes to action potential firing. However, the major Na + channel component is completely inactivated at -90 to -80 mV and is therefore inactive in the β-cell. It has been proposed that the biphasic inactivation reflects the contribution of different Na V α-subunits. We tested this possibility by expression of TTX-resistant variants of the Na V subunits found in β-cells (Na V 1.3, Na V 1.6 and Na V 1.7) in insulin-secreting Ins1 cells and in non-β-cells (including HEK and CHO cells). We found that all Na V subunits inactivated at 20-30 mV more negative membrane potentials in Ins1 cells than in HEK or CHO cells. The more negative inactivation in Ins1 cells does not involve a diffusible intracellular factor because the difference between Ins1 and CHO persisted after excision of the membrane. Na V 1.7 inactivated at 15--20 mV more negative membrane potentials than Na V 1.3 and Na V 1.6 in Ins1 cells but this small difference is insufficient to solely

  5. 17 CFR 240.16b-5 - Bona fide gifts and inheritance. (United States)


    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Bona fide gifts and inheritance. 240.16b-5 Section 240.16b-5 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... gifts and inheritance. Both the acquisition and the disposition of equity securities shall be exempt...

  6. Parochial trust and cooperation across 17 societies (United States)

    Romano, Angelo; Balliet, Daniel; Liu, James H.


    International challenges such as climate change, poverty, and intergroup conflict require countries to cooperate to solve these complex problems. However, the political tide in many countries has shifted inward, with skepticism and reluctance to cooperate with other countries. Thus, cross-societal investigations are needed to test theory about trust and cooperation within and between groups. We conducted an experimental study in 17 countries designed to test several theories that explain why, who, and where people trust and cooperate more with ingroup members, compared with outgroup members. The experiment involved several interactions in the trust game, either as a trustor or trustee. We manipulated partner group membership in the trust game (ingroup, outgroup, or unknown) and if their reputation was at stake during the interaction. In addition to the standard finding that participants trust and cooperate more with ingroup than outgroup members, we obtained findings that reputational concerns play a decisive role for promoting trust and cooperation universally across societies. Furthermore, men discriminated more in favor of their ingroup than women. Individual differences in cooperative preferences, as measured by social value orientation, predicted cooperation with both ingroup and outgroup members. Finally, we did not find support for three theories about the cross-societal conditions that influence the degree of ingroup favoritism observed across societies (e.g., material security, religiosity, and pathogen stress). We discuss the implications for promoting cooperation within and between countries. PMID:29133403

  7. Th1, Th17, CXCL16 and homocysteine elevated after intracranial and cervical stent implantation. (United States)

    Tang, Yanyan; Wei, Yunfei; Ye, Ziming; Qin, Chao


    The presence of Th1 and Th17 cells has been observed as major inducers in inflammation and immune responses associated stenting. However, there is rare data on the impact of Th1, Th17, CXCL16 and homocysteine after cerebral stent implantation. Here, we performed the statistical analysis to first evaluate the variation of the Th17and Th1 cells and their related cytokines, CXCL16 and homocysteine in the peripheral blood of patients with cerebral stenting. The flow cytometry was used to detect the proportion of Th1 and Th17 cells in peripheral blood mononuclear cells (PBMCs). The enzyme-linked immunosorbent assay was used to measure the serum concentrations of IFN-γ, IL-17 and CXCL16. Plasma homocysteine was examined by immunoturbidimetry. The level of Th1, CXCL16 and homocysteine showed an increase at 3 d, followed by the continuous decrease at 7 d and 3 months. The frequency of Th17 cells increased to a peak at three days, and subsequently decreased with a higher level than baseline. Our data revealed that the variation in Th1, Th17, CXCL16 and homocysteine in peripheral blood of patients with stenting may be implicated in inflammation after intracranial and cervical stent implantation. A better understanding of these factors will provide help for further drug design and clinical therapy.

  8. Most promising research : research peer exchange, August 16-17, 2011. (United States)


    The Iowa Department of Transportation held a Research Peer Exchange on August 16-17, 2011 in Ames, Iowa. RAC members from Region 3 (Minnesota, Iowa, Missouri, Ohio) and the following states, Louisiana, Washington, Oregon, South Dakota, Arizona and Ut...

  9. Hydraulic Conductivity Measurements with HTU at Eurajoki, Olkiluoto, Boreholes OL-KR16, 16B, 17, 17B, 18 and 18B, Year 2004

    Energy Technology Data Exchange (ETDEWEB)

    Haemaelaeinen, H.


    As a part of the site investigations for the disposal of spent nuclear fuel, hydraulic con- ductivity measurements were carried out in boreholes OL-KR16, 16B, 17, 17 B, 18 and 18B at Eurajoki, Olkiluoto. The objective was to investigate the distribution of the hydraulic conductivity in the surrounding bedrock volume. Measurements were carried out during spring-summer 2004. The total lengths of the boreholes are: OL-KR16 170,20 m, OL-KR17 157,13 m and OL-KR18 125,49 m. Corresponding B-holes are around 45 m deep, parallel and adjacent to their 'parent' holes so representing the cased sections of them. The conbined measurable length of the holes is about 453,57 m, of which 429,15 m was covered with 217 standard tests at 2 m packer separation as specified in the research plan. 246 tests were initiated, but some had to be cancelled due to errors or unsuitable control parameters. Double-packer constant-head method was used throughout with nominal 200 kPa overpressure. Injection stage lasted normally 20 minutes and fall-off stage 10 minutes. The tests were often shortened if there were clear indications that the hydraulic conductivity is below the measuring range of the system. The pressure in the test section was let to stabilise at least 5 min before injection. In some test sections the stabilisation, injection or fall-off stage lasted several hours. Two transient (Horner and 1/Q) interpretations and one stationary-state (Moye) interpretation were made in-situ immediately after the test. The Hydraulic Testing Unit (HTU-system) is owned by Posiva Oy and it was operated by Geopros Oy. (orig.)

  10. Statutory homelessness in England : the experience of families and 16-17 year olds


    Pleace, Nicholas; Fitzpatrick, Suzanne; Johnsen, Sarah; Quilgars, Deborah Jayne; Sanderson, Diana


    The research involved a nationally representative survey, covering 2,000 adults in homeless families and 500 children aged eight and above within those families. Using a specially developed sampling methodology, the survey draws a representative sample of homeless families over the course of a six month 'time window'. The research also involved two further surveys. The first is a survey of 500 lone homeless 16-17 year-olds. The second is a survey of 500 families and lone 16-17 year-olds who h...

  11. 17 CFR 240.16a-13 - Change in form of beneficial ownership. (United States)


    ... exercise or conversion of a derivative security or deposit into or withdrawal from a voting trust, that... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Change in form of beneficial ownership. 240.16a-13 Section 240.16a-13 Commodity and Securities Exchanges SECURITIES AND EXCHANGE...

  12. [Influence of physiologic 17 beta-estradiol concentrations on gene E6 expression in HVP type 18 in vitro]. (United States)

    Dziubińska-Parol, Izabella; Gasowska, Urszula; Rzymowska, Jolanta; Kwaśniewska, Anna


    Many recent studies indicate that long term use of contraceptives is a strong risk factor in the development of cervical cancer. Steroid hormones, in persistent papilloma virus infection act on various levels, one of them is enhancing transforming activity of the virus. The aim of the study was to estimate if physiological concentrations of 17 beta-estradiol could influence expression of viral transforming genes. HeLa cell lines were incubated with three different physiological concentrations and and on the third day of incubation the level of E6 gene expression was determined. Results show no differences in expression between the control culter, and cultures incubated with physiological concentrations. It indicates that normal levels of 17 beta-estradiol don't play role in transforming process but it also shows need to analyse higher levels of hormones by quantitative analyses in prospective studies.

  13. 16 CFR 460.17 - What installers must tell their customers. (United States)


    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false What installers must tell their customers... AND ADVERTISING OF HOME INSULATION § 460.17 What installers must tell their customers. If you are an installer, you must give your customers a contract or receipt for the insulation you install. For all...

  14. Laser Spectroscopy Monitoring of 13C18O16O and 12C17O16O of Atmospheric Carbon Dioxide (United States)

    Shorter, J. H.; Nelson, D. D.; Ono, S.; McManus, J. B.; Zahniser, M. S.


    One of the main challenges to making accurate predictions of future changes in CO2 concentration is the capability to determine what fraction of human produced CO2 remains in the atmosphere. We present our progress in the application of Tunable Infrared Laser Direct Absorption Spectroscopy (TILDAS) to the measurement of the primary clumped (13C18O16O) as well as 17O (12C17O16O) isotopologues of atmospheric CO2, as a tracer of its sources and sinks. We expect unique isotopologue signals in CO2 from high-temperature combustion sources, plants, soils, and air-sea exchange processes. High sampling frequency (a few minutes for each sample vs. reference cycle) achieved by a TILDAS instrument is expected to enable us to document local heterogeneous sources and temporal variations. The TILDAS is equipped with a newly developed 400-meter absorption cell. We designed a dual pressure measurement technique in which the clumped isotopologue, 13C18O16O, and 13C16O16O are first measured at 30 torr cell pressure. This is followed by measurement of 12C17O16O, 12C18O16O and 12C16O16O at lower ( 5 torr) cell pressure. Isotopologue ratios are compared between reference and sample gases. Preliminary tests demonstrated a precision approaching 0.03 ‰ for the ratio 13C18O16O/13C16O16O and 0.08‰ for Δ13C18O16O value (1σ repeatability for 4 min sample vs. reference cycle). Sample size for a single analysis is approximately 100 mL of air (1.6μmol of CO2). Given the previously observed range of variations for Δ13C18O16O and Δ17O values as large as 0.6 to 0.3 ‰, respectively, TILDAS offers a novel approach for real time monitoring of atmospheric CO2 isotopologues. It was found that achieving better than 0.1‰ requires careful matching of CO2 mixing ratios between reference and sample air. A primary cause of pressure and mixing ratio dependence is inaccurate baseline fitting (analogous to abundance sensitivity or pressure baseline for IRMS). Given that mixing ratios of atmospheric

  15. Behavioral and emotional problems reported by parents of children ages 6 to 16 in 31 societies

    DEFF Research Database (Denmark)

    Rescorla, L.; Achenbach, T.; Ivanova, M.Y.


    This study compared parents' ratings of behavioral and emotional problems on the Child Behavior Checklist (Achenbach, 1991; Achenbach & Rescorla, 2001) for general population samples of children ages 6 to 16 from 31 societies (N = 55,508). Effect sizes for society ranged from .03 to .14. Effect s...

  16. The Physiological Profile of Junior Soccer Players at SSBB Surabaya Bhakti (United States)

    Nashirudin, M.; Kusnanik, N. W.


    Soccer players are required to have good physical fitness in order to achieve optimum accomplishment; physical fitness stands as the foundation of technical and tactical proficiency as well as the mental maturity during the matches. The purpose of this study was to identify the physiological profile of junior soccer players of SSB Surabaya Bhakti age 16-17. The research was conducted at 20 junior soccer players. This research was quantitative with descriptive analysis. Data were collected by testing of physiological (anaerobic power and capacity including explosive leg power, speed, agility; aerobic capacity: cardiovascular endurance). Data was analyzed using percentage. The result showed that the percentage of explosive leg power of junior soccer players were 30% (good category), speed was 85% (average category), right agility was 90% (average category), left agility was 75% (average category). On the other hand, the aerobic power and capacity of the junior soccer players in this study was 50% (average category). The conclusion of this research is that the physiological profile of junior soccer players at SSB Surabaya Bhakti age 16-17 was majority in average category.

  17. Behavioral and emotional problems reported by parents of children ages 6 to 16 in 31 societies

    NARCIS (Netherlands)

    Rescorla, Leslie; Achenbach, Thomas; Ivanova, Masha Y.; Dumenci, Levent; Almqvist, Fredrik; Bilenberg, Niels; Bird, Hector; Chen, Wei; Dobrean, Anca; Doepfner, Manfred; Erol, Nese; Fombonne, Eric; Fonseca, Antonio; Frigerio, Alessandra; Grietens, Hans; Hannesdottir, Helga; Kanbayashi, Yasuko; Lambert, Michael; Larsson, Bo; Leung, Patrick; Liu, Xianchen; Minaei, Asghar; Mulatu, Mesfin S.; Novik, Torunn S.; Oh, Kyung-Ja; Roussos, Alexandra; Sawyer, Michael; Simsek, Zeynep; Steinhausen, Hans-Christoph; Weintraub, Sheila; Weisz, John; Metzke, Christa Winkler; Wolanczyk, Tomasz; Yang, Hao-Jan; Zilber, Nelly; Zukauskiene, Rita; Verhulst, Frank


    This study compared parents' ratings of behavioral and emotional problems on the Child Behavior Checklist (Achenbach, 199 1; Achenbach & Rescorla, 2001) for general population samples of children ages 6 to 16 from 31 societies (N = 55,508). Effect sizes for society ranged from.03 to.14. Effect sizes

  18. Antiprotozoal properties of 16,17-dihydrobrachycalyxolide from Vernonia brachycalyx

    DEFF Research Database (Denmark)

    Oketch-Rabah, H A; Brøgger Christensen, S; Frydenvang, K


    Extracts of the leaves from Vernonia brachycalyx showed in vitro activity against Plasmodium falciparum and promastigotes of Leishmania major. The germacrane dilactone 16,17-dihydrobrachycalyxolide (1) which was previously isolated from the aerial parts of the plant was shown to be the major...

  19. Blended learning within an undergraduate exercise physiology laboratory. (United States)

    Elmer, Steven J; Carter, Kathryn R; Armga, Austin J; Carter, Jason R


    In physiological education, blended course formats (integration of face-to-face and online instruction) can facilitate increased student learning, performance, and satisfaction in classroom settings. There is limited evidence on the effectiveness of using blending course formats in laboratory settings. We evaluated the impact of blended learning on student performance and perceptions in an undergraduate exercise physiology laboratory. Using a randomized, crossover design, four laboratory topics were delivered in either a blended or traditional format. For blended laboratories, content was offloaded to self-paced video demonstrations (∼15 min). Laboratory section 1 (n = 16) completed blended laboratories for 1) neuromuscular power and 2) blood lactate, whereas section 2 (n = 17) completed blended laboratories for 1) maximal O2 consumption and 2) muscle electromyography. Both sections completed the same assignments (scored in a blinded manner using a standardized rubric) and practicum exams (evaluated by two independent investigators). Pre- and postcourse surveys were used to assess student perceptions. Most students (∼79%) watched videos for both blended laboratories. Assignment scores did not differ between blended and traditional laboratories (P = 0.62) or between sections (P = 0.91). Practicum scores did not differ between sections (both P > 0.05). At the end of the course, students' perceived value of the blended format increased (P learning key foundational content through video demonstrations before class greatly enhanced their learning of course material compared with a preassigned reading (94% vs. 78%, P Blended exercise physiology laboratories provided an alternative method for delivering content that was favorably perceived by students and did not compromise student performance. Copyright © 2016 The American Physiological Society.

  20. Regolith irradiation stratigraphy at the Apollo 16 and 17 landing sites (United States)

    Crozaz, G.


    Additional fossil track measurements in the Apollo 17 deep drill stem, as well as detailed track studies in section 3 of the Apollo 16 deep drill core are reported. Although the upper part of the Apollo 17 core seems to have accreted rapidly, no evidence for a rapid accretion of the lower part, as postulated by some authors, is found. Despite the apparent inhomogeneity of section 60003, its track record is unexpectedly homogeneous; all levels are heavily irradiated and emplacement of big slabs of material is not favored.

  1. Behavioral and Emotional Problems Reported by Parents of Children Ages 6 to 16 in 31 Societies (United States)

    Rescorla, Leslie; Achenbach, Thomas; Ivanova, Masha Y.; Dumenci, Levent; Almqvist, Fredrik; Bilenberg, Niels; Bird, Hector; Chen, Wei; Dobrean, Anca; Dopfner, Manfred; Erol, Nese; Fombonne, Eric; Fonseca, Antonio; Frigerio, Alessandra; Grietens, Hans; Hannesdottir, Helga; Kanbayashi, Yasuko; Lambert, Michael; Larsson, Bo; Leung, Patrick; Liu, Xianchen; Minaei, Asghar; Mulatu, Mesfin S.; Novik, Torunn S.; Oh, Kyung-Ja; Roussos, Alexandra; Sawyer, Michael; Simsek, Zeynep; Steinhausen, Hans-Christoph; Weintraub, Sheila; Weisz, John; Metzke, Christa Winkler; Wolanczyk, Tomasz; Yang, Hao-Jan; Zilber, Nelly; Zukauskiene, Rita; Verhulst, Frank


    This study compared parents' ratings of behavioral and emotional problems on the "Child Behavior Checklist" (Achenbach, 1991; Achenbach & Rescorla, 2001) for general population samples of children ages 6 to 16 from 31 societies (N = 55,508). Effect sizes for society ranged from 0.03 to 0.14. Effect sizes for gender were less than or…

  2. Developmental validation of the PowerPlex(®) ESI 16/17 Fast and PowerPlex(®) ESX 16/17 Fast Systems. (United States)

    McLaren, Robert S; Bourdeau-Heller, Jeanne; Patel, Jaynish; Thompson, Jonelle M; Pagram, Jenny; Loake, Thomas; Beesley, David; Pirttimaa, Markus; Hill, Carolyn R; Duewer, David L; Kline, Margaret C; Butler, John M; Storts, Douglas R


    The PowerPlex(®) ESI 16 Fast, ESI 17 Fast, ESX 16 Fast, and ESX 17 Fast Systems represent faster cycling versions (50min or less) of the PowerPlex(®) ESI and ESX Systems released by Promega in 2009 to accommodate the ENFSI and EDNAP groups' call for new STR multiplexes for Europe. In addition to amplification of purified DNA samples, these new faster cycling systems allow for direct amplification from single-source blood and buccal samples deposited on FTA(®) and nonFTA paper as well as from SwabSolution™ extracts of buccal swabs without the need for purification and quantitation. There are no changes to the autosomal primer pair sequences in the PowerPlex(®) ESI Fast and ESX Fast Systems compared to the original multiplexes, and full concordance at all autosomal loci and amelogenin was observed with data generated previously with the original PowerPlex(®) ESI and ESX Systems. This paper describes the developmental validation study performed on these new fast systems following guidelines issued by the Scientific Working Group on DNA Analysis Methods (SWGDAM) and those of the DNA Advisory Board (DAB). Validation data demonstrate that these systems are sensitive for detecting low levels of DNA while also being capable of generating robust profiles from the high amount of input DNA present in direct-amplification samples. These systems are also tolerant to both high concentrations of PCR inhibitors as well as to slight variations in the final concentration of master mix and primer pair present in the amplification reaction that might be encountered due to pipetting error. The results of this validation study demonstrate that these systems may be used on multiple thermal cyclers and capillary electrophoresis platforms. Copyright © 2014 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

  3. Resonant states in 13C and 16,17O at high excitation energy (United States)

    Rodrigues, M. R. D.; Borello-Lewin, T.; Miyake, H.; Duarte, J. L. M.; Rodrigues, C. L.; Horodynski-Matsushigue, L. B.; Ukita, G. M.; Cappuzzello, F.; Cavallaro, M.; Foti, A.; Agodi, C.; Cunsolo, A.; Carbone, D.; Bondi, M.; De Napoli, M.; Roeder, B. T.; Linares, R.; Lombardo, I.


    The 9Be(6Li,d)13C and 12,13C(6Li,d)16,17O reactions were measured at the São Paulo Pelletron-Enge-Spectrograph facility at 25.5 MeV incident energy. The nuclear emulsion detection technique was applied. Several narrow resonances were populated up to approximately 17 MeV of excitation energy. An excellent energy resolution was obtained: 40 keV for 13C and 15-30 keV for 16O. The upper limit for the resonance widths were determined. Recently, d-a angular correlations were measured at θd = 0° with incident energy of 25 MeV using the LNS Tandem-MAGNEX Spectrometer facility.

  4. Resonant states in 13C and 16,17O at high excitation energy

    International Nuclear Information System (INIS)

    Rodrigues, M R D; Borello-Lewin, T; Miyake, H; Duarte, J L M; Rodrigues, C L; Horodynski-Matsushigue, L B; Ukita, G M; Cappuzzello, F; Foti, A; Cavallaro, M; Agodi, C; Cunsolo, A; Carbone, D; Bondi, M; Napoli, M De; Roeder, B T; Linares, R; Lombardo, I


    The 9 Be( 6 Li,d) 13 C and 12,13 C( 6 Li,d) 16,17 O reactions were measured at the São Paulo Pelletron-Enge-Spectrograph facility at 25.5 MeV incident energy. The nuclear emulsion detection technique was applied. Several narrow resonances were populated up to approximately 17 MeV of excitation energy. An excellent energy resolution was obtained: 40 keV for 13 C and 15-30 keV for 16 O. The upper limit for the resonance widths were determined. Recently, d-a angular correlations were measured at θ d = 0° with incident energy of 25 MeV using the LNS Tandem-MAGNEX Spectrometer facility

  5. Measurements and modeling of 16O12C17O spectroscopic parameters at 2 μm (United States)

    Jacquemart, David; Sung, Keeyoon; Coleman, Max; Crawford, Timothy; Brown, Linda R.; Mantz, Arlan W.; Smith, Mary Ann H.


    The lack of spectroscopic measurements for rare CO2 isotopologues was the main motivation of this work. In our present study we report line intensity measurements for 16O12C17O made with a high resolution Fourier transform spectrometer (Bruker IFS-125HR) and a 21 m path cryogenic Herriott cell at Jet Propulsion Laboratory. For this, a 17O-enriched CO2 gas sample was used, which comes as a mixture of primary and several minor CO2 isotopologues. The mole fraction of the 16O12C17O isotopologue in the mixture was determined to be 0.3991 by mass spectrometry from a Stable Isotope Ratio Mass Spectrometer (SIRMS) under stochastic distribution assumption at thermal equilibrium. Since the collisional narrowing effect was observed, the Rautian molecular line shape profile was systematically adopted instead of the Voigt profile. Absolute line positions were also investigated by performing a wavenumber calibration based on CO, HCl and a few well-known 16O12C16O transitions. Finally, around 1000 transitions were studied between 4604 and 5126 cm-1 involving 15 bands of the 16O12C17O isotopologue. All the measured line intensities were renormalized to be the values for 100% pure isotopologue sample. Transition dipole moments and Herman-Wallis factors were derived enabling a global comparison with theoretical calculations and predictions for the 15 bands of the 16O12C17O isotopologue. For the measured line positions, the absolute accuracy is around 2×10-4 cm-1. The accuracies of retrieved line intensities are 2 - 5% for five cold and two hot bands, and 6-30% for eight other weaker hot bands. Results from this work were in a good agreement with HITRAN 2012 for positions, but showed rather significant discrepancies for line intensities. An extensive line list was generated from new experimental measurements in order to improve and validate spectroscopic knowledge of 12C16O17O isotopologue in support of atmospheric remote sensing for the Earth (e.g., OCO-2 mission), Mars and Venus.

  6. Nigerian Journal of Physiological Sciences

    African Journals Online (AJOL)

    Nigerian Journal of Physiological Sciences (Niger. J. Physiol. Sci.) is a biannual publication of the Physiological Society of Nigeria. It covers diverse areas of research in physiological sciences, publishing reviews in current research areas and original laboratory and clinical research in physiological sciences. Other websites ...

  7. The focus of women in The American Fertility Society. (United States)

    Haseltine, F P; Wentz, A C


    This article reports survey responses from 71 female members of the American Fertility Society during the Society's 1984 annual meeting. Survey questions concern 1) demographic factors such as rank, degree, title, address, and number of children, 2) field of specialization and research interests, and 3) what the Society can do for its meeting participants. The typical respondent is a physician living in the Eastern United States and employed as an assistant professor in an academic setting. In vitro fertilization is the greatest area of interest, followed by general practice, endocrine and male infertility, contraception, and fertility surgery. Survey responses show that women are interested in 1) networking, 2) increased visibility at professional meetings, 3) information about research possibilities and grants, 4) child care provision at Society meetings, and 5) more basic science and physiology oriented presentions in the program. In response to networking interests, the Society will make available information from the surveyed members. Since 16% of respondents have a PH.D., and 77% are employed in academics, the Society should consider more basic presentations. The need for day care indicates changes in Society membership. The Society plans to conduct similar surveys on a regular basis.

  8. A history of the Federation of European Societies of Plant Physiology FESPP since its foundation in 1978--including notes on events preceding the foundation and following re-naming as the Federation of European Societies of Plant Biology (FESPB) in 2002. (United States)

    Lichtenthaler, Hartmut


    After several years of close contacts and extensive discussion between various plant physiologists of different European countries, the Federation of European Societies of Plant Physiology (FESPP) was established in 1978 in Edinburgh. The aim of the FESPP was and remains to promote up-to-date plant physiology research in all European countries and to stimulate scientific cooperation and the exchange of scientists between the different member societies by organizing congresses and workshops as well as editing four (recently five) Federation-affiliated journals. The short History of FESPP presented here covers the preparatory years of the 1970s that led to its actual foundation in 1978, and then its further development up to and following the Federation's reconstitution in 2002 as the Federation of European Societies of Plant Biology (FESPB).

  9. Updating the Geologic Maps of the Apollo 15, 16, and 17 Landing Sites (United States)

    Garry, W. B.; Mest, S. C.; Yingst, R. A.; Ostrach, L. R.; Petro, N. E.; Cohen, B. A.


    Our team is funded through NASA's Planetary Data Archiving, Restoration, and Tools (PDART) program to produce two new USGS Special Investigation Maps (SIM) for the Apollo 15, 16, and 17 missions: a regional map (1:200K) and a landing-site map (1:24K).

  10. 17 CFR 240.11a1-6 - Transactions for certain accounts of OTC derivatives dealers. (United States)


    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Transactions for certain accounts of OTC derivatives dealers. 240.11a1-6 Section 240.11a1-6 Commodity and Securities Exchanges... effected by a member of a national securities exchange for the account of an OTC derivatives dealer that is...

  11. Preparation of 16α[18F] fluoro-17β-fluoroestradiol on domestic synthesis module

    International Nuclear Information System (INIS)

    Sun Chuanjin; Zhu Hong; Fang Keyuan


    To investigate the synthesis method of 16α-[ 18 F] fluoro-17β-fluoroestradiol on domestic synthesizing module, the automated synthesis was carried out through the reaction of 3-O-(methoxymethyl) -16,17-O-sulfuryl-16-epiestriol (MMSE, 1 mg) as precursor with 18 F- at 105 ℃ for 15 min in sealed system on domestic synthesizer, then 0.8 mL 1 mol/L HC1 dissolved in 7.2 mL acetonetrile was added in three parts to the reaction vessel for hydrolysis and hydrolysis reaction was performed at 105 ℃ for 6 min. The final reaction solution was purified by HPLC to give 18 F-FES. Preparation of 18 F-FES on domestic synthesis module was in the uncorrected synthesis yield of 8.2% (corrected synthesis yield 12.8%). Total synthesis time was about 70 min and radiochemical purity was higher than 98%. The product had good stability at room temperature. 18 F-FES injection can be prepared on domes- tic synthesis module and the quality can meet the requirements of radiopharmaceuticals for clinical use, (authors)

  12. The emergence of Applied Physiology within the discipline of Physiology. (United States)

    Tipton, Charles M


    Despite the availability and utilization of the physiology textbooks authored by Albrecht von Haller during the 18th century that heralded the modern age of physiology, not all physicians or physiologists were satisfied with its presentation, contents, or application to medicine. Initial reasons were fundamental disagreements between the "mechanists," represented by Boerhaave, Robinson, and von Haller, and the "vitalists," represented by the faculty and graduates of the Montpellier School of Medicine in France, notably, Bordeu and Barthez. Subsequently, objections originated from Europe, United Kingdom, and the United States in publications that focused not only on the teaching of physiology to medical and secondary students, but on the specific applications of the content of physiology to medicine, health, hygiene, pathology, and chronic diseases. At the turn of the 20th century, texts began to appear with applied physiology in their titles and in 1926, physician Samson Wright published a textbook entitled Applied Physiology that was intended for both medical students and the medical profession. Eleven years later, physicians Best and Taylor published The Physiological Basis of Medical Practice: A University of Toronto Texbook in Applied Physiology Although both sets of authors defined the connection between applied physiology and physiology, they failed to define the areas of physiology that were included within applied physiology. This was accomplished by the American Physiological Society (APS) Publications Committee in 1948 with the publication of the Journal of Appplied Physiology, that stated the word "applied" would broadly denote human physiology whereas the terms stress and environment would broadly include work, exercise, plus industrial, climatic and social factors. NIH established a study section (SS) devoted to applied physiology in 1964 which remained active until 2001 when it became amalgamated into other SSs. Before the end of the 20th century when

  13. 17 CFR 260.7a-16 - Inclusion of items, differentiation between items and answers, omission of instructions. (United States)


    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Inclusion of items, differentiation between items and answers, omission of instructions. 260.7a-16 Section 260.7a-16 Commodity and... INDENTURE ACT OF 1939 Formal Requirements § 260.7a-16 Inclusion of items, differentiation between items and...

  14. Conversos and Freethought. Searching for Traces (16th and 17th c.

    Directory of Open Access Journals (Sweden)

    Markus Schreiber


    Full Text Available In the 16th and 17th centuries, among Iberian New Christians there can be detected some radical manifestations of religious disruption. Following the research of Yitzhak Baer, Carl Gebhardt and most notably Israël S. Révah, these phenomena repeatedly have been linked both to late medieval Jewish «averroism» and the Spinozistic philosophy of the 17th century. However, more perspectives are possible. Here, we would like to present the trends of converso unbelieve with their academic background and in the European context, paying special attention to a group of five New Christian physicians, who, about 1630, together studied at the University of Alcalá de Henares.

  15. Enterobacter asburiae KE17 association regulates physiological changes and mitigates the toxic effects of heavy metals in soybean. (United States)

    Kang, S-M; Radhakrishnan, R; You, Y-H; Khan, A-L; Lee, K-E; Lee, J-D; Lee, I-J


    This study aimed to elucidate the role played by Enterobacter asburiae KE17 in the growth and metabolism of soybeans during copper (100 μm Cu) and zinc (100 μm Zn) toxicity. When compared to controls, plants grown under Cu and Zn stress exhibited significantly lower growth rates, but inoculation with E. asburiae KE17 increased growth rates of stressed plants. The concentrations of plant hormones (abscisic acid and salicylic acid) and rates of lipid peroxidation were higher in plants under heavy metal stress, while total chlorophyll, carotenoid content and total polyphenol concentration were lower. While the bacterial treatment reduced the abscisic acid and salicylic acid content and lipid peroxidation rate of Cu-stressed plants, it also increased the concentration of photosynthetic pigments and total polyphenol. Moreover, the heavy metals induced increased accumulation of free amino acids such as aspartic acid, threonine, serine, glycine, alanine, leucine, isoleucine, tyrosine, proline and gamma-aminobutyric acid, while E. asburiae KE17 significantly reduced concentrations of free amino acids in metal-affected plants. Co-treatment with E. asburiae KE17 regulated nutrient uptake by enhancing nitrogen content and inhibiting Cu and Zn accumulation in soybean plants. The results of this study suggest that E. asburiae KE17 mitigates the effects of Cu and Zn stress by reprogramming plant metabolic processes. © 2015 German Botanical Society and The Royal Botanical Society of the Netherlands.

  16. Biotransformation of cholesterol and 16,17-alpha epoxypregnenolone by novel Cladosporium sp. strain IS547. (United States)

    Pang, Cuiping; Cao, Yuting; Zhu, Xiangdong


    Nowadays, there are a few steroid drugs or intermediates that have been obtained via the transformation of microorganisms, and many strains of transformed steroids have not been found yet. Therefore, it is very significant to screen for the strains that have the abilities to transform steroids to produce valuable products. This study has focused on the screen and identification of strains, the structural identification of converted products, and the optimization of transformation conditions, as well as the establishment of transformation systems. A soil microbiota was screened for strain involved in the biotransformation of steroids. A new isolate IS547 is capable of converting a variety of steroids (such as cholesterol, ergosterol, hydrocortisone, progesterone, pregnenolone, and 16,17-alpha-epoxypregnenolone). Based on the 18S rDNA gene sequence comparison, the isolate IS547 has been demonstrated to be very closely related to Cladosporium sp. genus. Present paper is the first report regarding the microbial transformation by Cladosporium sp. to produce active intermediates, which include 7-hydroxy cholesterol, 20-droxyl-16α,17α-epoxypregna-4-dien-3-one, 7-ketocholesterol, and 7-droxyl-16α,17α-epoxypregna-4-dien-3,20-dione. Under the optimum conditions, the yields of product 3 and product 4 were 20.58 and 17.42%, respectively, higher than that prior to the optimization. The transformation rate increased significantly under the optimum fermentation conditions. This study describes an efficient, rapid, and inexpensive biotransformation system for the production of active pharmaceutical intermediates. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Proceedings of the Korean Society Nuclear Medicine Autumn Meeting 2001

    International Nuclear Information System (INIS)


    This proceedings contains articles of 2001 autumn meeting of the Korean Society Nuclear Medicine. It was held on November 16-17, 2001 in Seoul, Korea. This proceedings is comprised of 6 sessions. The subject titles of session are as follows: Cancer, Physics of nuclear medicine, Neurology, Radiopharmacy and biology, Nuclear cardiology, General nuclear medicine. (Yi, J. H.)

  18. 25th Annual International Laser Physics Workshop (LPHYS’16)

    International Nuclear Information System (INIS)


    EDITORIALDear Readers,The 25th annual International Laser Physics Workshop, LPHYS’16, took place in the city of Yerevan, Republic of Armenia. 319 participants from 32 countries attended the conference. It was hosted by the Yerevan Physics Institute, A Alikhanyan National Laboratory. This year the conference has been endorsed by the Optical Society (OSA), the year the society celebrates its 100th anniversary.The LPHYS’16 Steering Committee and the Advisory and Program Committee would like to extend their sincere gratitude to Dr. Koryun B Oganesyan (Chair of the Local Organizing Committee) and to his team for the outstanding job performed on organizing, arranging, managing and putting in order the conference. Their combined effort lead to a successful result.In this volume of the IOP Journal of Physics: Conference Series you will find selected proceedings of the Workshop in Yerevan.Please make a note that the 26th annual International Laser Physics Workshop (LPHYS’17) will take place from July 17 to July 21, 2017 in the city of Kazan, Russia hosted by the Kazan E K Zavoisky Physical-Technical Institute (KPhTI).With kind regards,Steering and Advisory and Program committeesLPHYS’16 (paper)

  19. [Construction of a physiological aging scale for healthy people based on a modified Delphi method]. (United States)

    Long, Yao; Zhou, Xuan; Deng, Pengfei; Liao, Xiong; Wu, Lei; Zhou, Jianming; Huang, Helang


    To build a physiological aging scale for healthy people.
 We collected age-related physiologic items through literature screening and expert interview. Two rounds of Delphi were implemented. The importance, feasibility and the degree of authority for the physiological index system were graded. Using analytic hierarchy process, we determined the weight of dimensions and items.
 Using Delphy mothod, 17 physiological and other professional experts offered the results as follow: coefficient of expert authorities Cr was 0.86±0.03, coordination coefficients for the first and second round were 0.264(χ2=229.691, Paging scale for healthy people included 3 dimensions, namely physical form, feeling movement and functional status. Each dimension had 8 items. The weight coefficients for the 3 dimensions were 0.54, 0.16, and 0.30, respectively. The Cronbach's α coefficient of the scale was 0.893, the reliability was 0.796, and the variance of the common factor was 58.17%.
 The improved Delphi method or physiological aging scale is satisfied, which can provide reference for the evaluation of aging.

  20. Images of the Other in the German Travel Accounts of the 16th and 17th Century

    Directory of Open Access Journals (Sweden)

    Andreja Bole


    Full Text Available This paper points out the image of the Russian in the selected German travel accounts of the 16th and 17th century, through the eyes of the West European well-educated legate seen as a savage, boorish Barbarian. The image of the Russian illustrates the importance of the relationship between the one’s own, civilized (here German and the other, often barbaric (here Russian cultural reality. Key words: Images of the Other / Travel Account / Herberstein, Olearius / Russia of the 16th and 17th Century.

  1. An Experimental Study on What Controls the Ratios of 18O/16O and 17O/16O of O2 During Microbial Respiration (United States)

    Stolper, D. A.; Ward, B. B.; Fischer, W. W.; Bender, M. L.


    18O/16O and 17O/16O ratios of atmospheric and dissolved oceanic O2 are key biogeochemical tracers of total photosynthesis and respiration on global to local length scales and glacial/interglacial time scales (Luz et al., 1999). Critical to the use of these ratios as biogeochemical tracers is knowledge of how they are affected by production, consumption, and transport of O2. We present new measurements of O2 respiration by E. coli and N. oceanus, an ammonia oxidizing bacterium, to test three assumptions of isotopically enabled models of the O2 cycle: (i) laboratory-measured respiratory 18O/16O isotope effects (18α) of microorganisms are constant under all experimental and natural conditions (e.g., temperature and growth rate); (ii) the respiratory 'mass law' relationship between 18O/16O and 17O/16O [17α = (18α)β] is universal; and (iii) 18α and β for aerobic ammonia and organic carbon oxidation are identical. For E. coli, we find that both 18α and β are variable. From 37°C to 15°C, 18α varies linearly with temperature from 17 to 14‰, and β varies linearly from 0.513 to 0.508. 18α and β do not appear to vary with growth rate (as tested using different carbon sources). Both 18α and β are lower than previous observations for bacteria: 18α = 17-20‰ (Kiddon et al., 1993) and β = 0.515 (Luz and Barkan, 2005). We were able to simulate the observed temperature dependence of 18α and β using a model of respiration with two isotopically discriminating steps: O2 binding to cytochrome bo oxidase (the respiratory enzyme) and reduction of O2 to H2O. Finally, initial results on N. oceanus suggest it has similar values for 18α and β as previously studied aerobic bacteria that consume organic carbon, providing the first support for assumption (iii). Based on these results, isotopically constrained biogeochemical models of O2 cycling may need to consider a temperature dependence for 18α and β for microbial respiration. For example, these results may

  2. The lactoferricin B-derived peptide, LfB17-34, induces melanogenesis in B16F10 cells. (United States)

    Huang, Hsiu-Chin; Lin, Hsuan; Huang, Min-Chuan


    Lactoferricin B (LfcinB), a peptide of bovine lactoferrin (LfB), exhibits multiple biological functions, including antimicrobial, antiviral, antioxidant and immunomodulatory activities. However, the role of LfcinB-related peptides in melanogenesis remains unclear. In this study, a set of five LfcinB-related peptides was examined. We found that LfB17‑34, an 18-mer LfcinB-derived peptide, increased melanogenesis in B16F10 melanoma cells without significantly affecting cell viability. LfB17‑34 increased in vitro tyrosinase activity and melanin content in a dose-dependent manner. The results of RT-qPCR and western blot analyses showed that LfB17‑34 increased the mRNA and protein expression of tyrosinase and tyrosinase-related protein 1 (Trp1). Moreover, LfB17‑34 inhibited the phosphorylation of MAPK/Erk, but not p38 and Akt, and constitutively active MEK was able to reverse the LfB17-34-enhanced pigmentation, melanin content, and tyrosinase activity, suggesting a role of Erk signaling in the process of LfB17‑34-mediated pigmentation. Taken together, these results suggest that LfB17‑34 induces melanogenesis in B16F10 cells primarily through increased tyrosinase expression and activity and that LfB17‑34 could be further developed for the treatment of hypopigmentation disorders.

  3. 16th Carbonyl Metabolism Meeting: from enzymology to genomics

    Directory of Open Access Journals (Sweden)

    Maser Edmund


    Full Text Available Abstract The 16th International Meeting on the Enzymology and Molecular Biology of Carbonyl Metabolism, Castle of Ploen (Schleswig-Holstein, Germany, July 10–15, 2012, covered all aspects of NAD(P-dependent oxido-reductases that are involved in the general metabolism of xenobiotic and physiological carbonyl compounds. Starting 30 years ago with enzyme purification, structure elucidation and enzyme kinetics, the Carbonyl Society members have meanwhile established internationally recognized enzyme nomenclature systems and now consider aspects of enzyme genomics and enzyme evolution along with their roles in diseases. The 16th international meeting included lectures from international speakers from all over the world.

  4. JPRS Report, Science & Technology, Japan, International Society of Electrochemistry Meeting (40th) Held in Kyoto on 17-22 Sep 89

    National Research Council Canada - National Science Library


    Selected "extended abstracts" presented at the 40th International Society of Electrochemistry Meeting held 17-22 Sep 89 in Kyoto, sponsored by the International Union of Pure and Applied Chemistry (IUPAC...

  5. Nigerian Journal of Physiological Sciences: Editorial Policies

    African Journals Online (AJOL)

    Focus and Scope. Nigerian Journal of Physiological Sciences (Niger. J. Physiol. Sci.) is a biannual publication of the Physiological Society of Nigeria. It covers diverse areas of research in physiological sciences, publishing reviews in current research areas and original laboratory and clinical research in physiological ...

  6. 17 CFR 8.16 - Settlement offers. (United States)


    ... Section 8.16 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION EXCHANGE PROCEDURES FOR DISCIPLINARY, SUMMARY, AND MEMBERSHIP DENIAL ACTIONS Disciplinary Procedure § 8.16 Settlement... the disciplinary committee at any time after the investigation report is completed. The disciplinary...

  7. Proceedings of the 17. Annual Meeting of the Brazilian Chemistry Society; 7. National Symposium on Inorganic Chemistry. Abstracts

    International Nuclear Information System (INIS)


    These 17. Annual Meeting of the Brazilian Chemistry Society and 7. National Symposium on Inorganic Chemistry present several subjects of different interests for the participants, including sections about inorganic chemistry; organic chemistry; environmental chemistry; technological chemistry; electrochemistry; physical chemistry; photochemistry; chemical education; natural products; analytical chemistry and biological chemistry. (C.G.C.)

  8. 16 CFR 1025.17 - Intervention. (United States)


    ... PROCEEDINGS Pleadings, Form, Execution, Service of Documents § 1025.17 Intervention. (a) Participation as an.... (2) A request shall set forth the nature and extent of the person's alleged interest in the... following factors: (1) The nature of the petitioner's interest, under the applicable statute governing the...

  9. Highlights of the 16th annual scientific sessions of the Society for Cardiovascular Magnetic Resonance. (United States)

    Carpenter, John-Paul; Patel, Amit R; Fernandes, Juliano Lara


    The 16th Annual Scientific Sessions of the Society for Cardiovascular Magnetic Resonance (SCMR) took place in San Francisco, USA at the end of January 2013. With a faculty of experts from across the world, this congress provided a wealth of insight into cutting-edge research and technological development. This review article intends to provide a highlight of what represented the most significant advances in the field of cardiovascular magnetic resonance (CMR) during this year's meeting.

  10. Multimodal integration of anatomy and physiology classes: How instructors utilize multimodal teaching in their classrooms (United States)

    McGraw, Gerald M., Jr.

    Multimodality is the theory of communication as it applies to social and educational semiotics (making meaning through the use of multiple signs and symbols). The term multimodality describes a communication methodology that includes multiple textual, aural, and visual applications (modes) that are woven together to create what is referred to as an artifact. Multimodal teaching methodology attempts to create a deeper meaning to course content by activating the higher cognitive areas of the student's brain, creating a more sustained retention of the information (Murray, 2009). The introduction of multimodality educational methodologies as a means to more optimally engage students has been documented within educational literature. However, studies analyzing the distribution and penetration into basic sciences, more specifically anatomy and physiology, have not been forthcoming. This study used a quantitative survey design to determine the degree to which instructors integrated multimodality teaching practices into their course curricula. The instrument used for the study was designed by the researcher based on evidence found in the literature and sent to members of three associations/societies for anatomy and physiology instructors: the Human Anatomy and Physiology Society; the iTeach Anatomy & Physiology Collaborate; and the American Physiology Society. Respondents totaled 182 instructor members of two- and four-year, private and public higher learning colleges collected from the three organizations collectively with over 13,500 members in over 925 higher learning institutions nationwide. The study concluded that the expansion of multimodal methodologies into anatomy and physiology classrooms is at the beginning of the process and that there is ample opportunity for expansion. Instructors continue to use lecture as their primary means of interaction with students. Email is still the major form of out-of-class communication for full-time instructors. Instructors with

  11. Nuclear Landau-Zener phenomena and the fusion cross sections in the system 13C + 16O → 12C + 17O

    International Nuclear Information System (INIS)

    Imanishi, B.; Oertzen, W. von.


    Reaction mechanism of the system 13 C+ 16 O- 12 C+ 17 O is investigated with the use of the nucleon molecular-orbital model in the framework of the orthogonalized coupled-reaction-channel (OCRC) theory. The adiabatic potentials obtained are quite different from the diagonal potentials of the original OCRC basis. The Landau-Zener radial coupling explains the backward enhancement of measured differential cross sections of the transfer reaction 13 C( 16 O, 17 O) 12 C. In the OCRC calculation the fusion cross sections of the channel 13 C+ 16 O is enhanced at low bombarding energies, in agreement with the experimental data. (author)

  12. [Right of access to healthcare in the context of the Royal Decree-Law 16/2012: the perspective of civil society organizations and professional associations]. (United States)

    Suess, Amets; Ruiz Pérez, Isabel; Ruiz Azarola, Ainhoa; March Cerdà, Joan Carles


    The recent publication of the Royal Decree-Law 16/2012 (RDL 16/2012), which introduces structural changes in the Spanish Public Healthcare System, can be placed in the broader context of budgetary adjustments in response to the current economic crisis. An analysis of the interrelationships among economic crisis, healthcare policies, and health reveals that citizen participation is one of several potential strategies for reducing the impact of this situation on the population. This observation raises the interest to know the citizens' perspectives on the modifications introduced by the RDL 16/2012. Narrative review of documents related to the RDL 16/2012 published by civil society organizations and professional associations in the Spanish context. A broad citizen response can be observed to the introduction of RDL 16/2012. The documents reviewed include an analysis of changes in the healthcare model inherent to the RDL 16/2012, as well as predictions on its impact on access to healthcare, healthcare quality, and health. The civil society organizations and professional associations offer recommendations and proposals, as well as collaboration in elaborating alternative strategies to reduce costs. The response of civil society organizations and professional associations underscores the importance of strengthening citizen participation in the development of healthcare policies aimed at maintaining the universal character and sustainability of the Spanish Public Healthcare System in the current moment of economic and systemic crisis. Copyright © 2014 SESPAS. Published by Elsevier Espana. All rights reserved.

  13. Cardiorespiratory physiological phenotypic plasticity in developing air-breathing anabantid fishes (Betta splendens and Trichopodus trichopterus). (United States)

    Mendez-Sanchez, Jose F; Burggren, Warren W


    Developmental plasticity of cardiorespiratory physiology in response to chronic hypoxia is poorly understood in larval fishes, especially larval air-breathing fishes, which eventually in their development can at least partially "escape" hypoxia through air breathing. Whether the development air breathing makes these larval fishes less or more developmentally plastic than strictly water breathing larval fishes remains unknown. Consequently, developmental plasticity of cardiorespiratory physiology was determined in two air-breathing anabantid fishes ( Betta splendens and Trichopodus trichopterus ). Larvae of both species experienced an hypoxic exposure that mimicked their natural environmental conditions, namely chronic nocturnal hypoxia (12 h at 17 kPa or 14 kPa), with a daily return to diurnal normoxia. Chronic hypoxic exposures were made from hatching through 35 days postfertilization, and opercular and heart rates measured as development progressed. Opercular and heart rates in normoxia were not affected by chronic nocturnal hypoxic. However, routine oxygen consumption M˙O2 (~4  μ mol·O 2 /g per hour in normoxia in larval Betta ) was significantly elevated by chronic nocturnal hypoxia at 17 kPa but not by more severe (14 kPa) nocturnal hypoxia. Routine M˙O2 in Trichopodus (6-7  μ mol·O 2 /g per hour), significantly higher than in Betta , was unaffected by either level of chronic hypoxia. P Crit , the PO 2 at which M˙O2 decreases as ambient PO 2 falls, was measured at 35 dpf, and decreased with increasing chronic hypoxia in Betta , indicating a large, relatively plastic hypoxic tolerance. However, in contrast, P Crit in Trichopodus increased as rearing conditions grew more hypoxic, suggesting that hypoxic acclimation led to lowered hypoxic resistance. Species-specific differences in larval physiological developmental plasticity thus emerge between the relatively closely related Betta and Trichopodus Hypoxic rearing increased hypoxic tolerance in

  14. Physiology of man and animals in the Tenth Five-Year Plan: Proceedings of the Thirteenth Congress of the I. P. Pavlov All-Union Physiological Society (United States)

    Lange, K. A.


    Research in the field of animal and human physiology is reviewed. The following topics on problems of physiological science and related fields of knowledge are discussed: neurophysiology and higher nervous activity, physiology of sensory systems, physiology of visceral systems, evolutionary and ecological physiology, physiological cybernetics, computer application in physiology, information support of physiological research, history and theory of development of physiology. Also discussed were: artificial intelligence, physiological problems of reflex therapy, correlation of structure and function of the brain, adaptation and activity, microcirculation, and physiological studies in nerve and mental diseases.

  15. Building Energy Management Systems BEMS, German contribution to the IEA research projects Annex 16 and 17. Building Energy Management System BEMS; deutscher Beitrag zu den IEA-Forschungsvorhaben Annex 16 und 17

    Energy Technology Data Exchange (ETDEWEB)

    Bach, H.; Stephan, W.; Madjidi, M. (Univ. Stuttgart, IKE, Abt. HLK (Germany)); Brendel, T.; Schneider, A. (Ingenieurbuero Dr. Brendel, Frankfurt am Main (Germany)); Ast, H.; Kellner, H. (IFB, Dr. R. Braschel GmbH, Stuttgart (Germany))


    As part of the IEA project Annex 16 and 17 Germany carries out the project Building Energy Management Systems (BEMS). With digital control systems energetic and low-cost operation of space hvac systems can be attained. The project aims at abolishing impediments to efficient use of energy. Potential savings are shown for three examples: A conventional heating system for an office building, a VAV system (circulating air, heating, cooling, washer humidifcation) for an office building and VAV systems (FWRG, heating, cooling, steam humidification) for an office building in compact design. (BWI).

  16. Problems of Journalism; Proceedings of the 1975 Annual Convention of the American Society of Newspaper Editors (Washington, D.C., April 16-18, 1975). (United States)

    American Society of Newspaper Editors, Easton, PA.

    This document reports the 1975 proceedings of the American Society of Newspaper Editors (ASNE) convention held in Washington, D.C., April 16-18. The contents include a list of officers and directors, past presidents of the society, and a copy of the ASNE Code of Ethics. Also contained in the document are reports on such individual sessions as…

  17. XXII congress of the European Society of Neuroradiology. 6th advanced course. Milan, Italy 17-21 September 1996

    International Nuclear Information System (INIS)

    Scotti, G.


    The 22nd Congress of the European Society of Neuroradiology, held from 17 -21 September 1996 in Milano, Italy, was dedicated to the neuroradiological aspects of diagnosis and treatment of lesions of the central nervous system. The proceedings issue presents the full Congress programme, the abstracts of the 147 oral presentations as well as the 307 poster presentations. There also is an author index and a list of ESNR members. (Orig./MG) [de

  18. Conservation physiology of marine fishes

    DEFF Research Database (Denmark)

    Jørgensen, Christian; Peck, Myron A.; Antognarelli, Fabio


    At the end of May, 17 scientists involved in an EU COST Action on Conservation Physiology of Marine Fishes met in Oristano, Sardinia, to discuss how physiology can be better used in modelling tools to aid in management of marine ecosystems. Current modelling approaches incorporate physiology...... to different extents, ranging from no explicit consideration to detailed physiological mechanisms, and across scales from a single fish to global fishery resources. Biologists from different sub-disciplines are collaborating to rise to the challenge of projecting future changes in distribution and productivity...

  19. 16.-17. sajandi kirikukalmistu luustike antropoloogiline analüüs (Tallinn Suur-Kloostri 14) / Raili Allmäe

    Index Scriptorium Estoniae

    Allmäe, Raili, 1963-


    Tallinna Issanda Muutmise kiriku territooriumil 2003. aastal toimunud arheoloogilistest kaevamistest. Peamiselt 16.-17. sajandi kalmistul fikseeriti 144 matust. Laste matuste suur osakaal matuste üldhulgast võib viidata kiriku juures tegutsenud õppeasutusele või laste hoolekandeasutusele

  20. Russian Monastery’s Accounting and Auditing in the 16th –17th Centuries


    Ivanov, Vladimir


    This paper reviews a history of accounting and auditing practice in 16th-17th centuries at the most known monastery of Russia – Solovetsky. This monastery was established in the first half of 15th c. For the first time the earliest of the preserved accounting documents of the monastery - saint hegumen Philip’s “memory” of donations and expense to the cloister building (1547/48) is introduced. The evolution of accounting system and basic principles of the income-expenditure books’ composition ...

  1. 17 CFR 210.3-16 - Financial statements of affiliates whose securities collateralize an issue registered or being... (United States)


    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Financial statements of... FOR FINANCIAL STATEMENTS, SECURITIES ACT OF 1933, SECURITIES EXCHANGE ACT OF 1934, PUBLIC UTILITY... POLICY AND CONSERVATION ACT OF 1975 General Instructions As to Financial Statements § 210.3-16 Financial...

  2. Gastrin is not a physiological regulator of pancreatic exocrine secretion in the dog

    International Nuclear Information System (INIS)

    Koehler, E.; Beglinger, C.; Eysselein, V.; Groetzinger, U.; Gyr, K.


    The role of gastrin as a regulator of exocrine pancreatic secretion has not been proven adequately. In the present study the authors therefore compared the relative molar potencies of sulfated and unsulfated gastrin 17 with structurally related CCK peptides (synthetic CCK-8 and natural porcine CCK-33) in stimulating exocrine pancreatic secretion in conscious dogs. Dose response curves were constructed for pancreatic and gastric acid secretion. Plasma gastrin levels after exogenous gastrin 17-I and -II were compared with postprandial gastrin concentrations. The molar potency estimates calculated with synthetic CCK8 as standard for pancreatic protein secretion were natural porcine 50% pure CCK-33 1.60, gastrin 17-I 0.12, and gastrin 17-II 0.16. All four peptides induced a dose-dependent increase in pancreatic bicarbonate output. However, the blood concentrations needed to stimulate pancreatic secretion were above the postprandial gastrin levels. The data indicate that both gastrin 17 peptides are not physiological regulators of pancreatic enzyme secretion in dogs

  3. Homer Wheelon, M.D., physiologist, artist, and poet: origins of the tailpieces in journals of the American Physiological Society. (United States)

    Schramm, Lawrence P; Schramm, Diana C; Jackson, F Wilson


    Since 1953, illustrations have been inserted as "tailpieces" at the ends of articles in The American Journal of Physiology and The Journal of Applied Physiology. The drawings were made by Homer Wheelon, a member of the American Physiological Society from 1919 until his death in 1960. Forty-five years after his death, Wheelon is unknown, but he contributed 32 publications to the medical literature and trained J. Earl Thomas, an important 20th century gastrointestinal physiologist. Wheelon was born into poverty in 1883 to itinerant Methodist preachers, circumstances that guided his education and career choices. Throughout his life, Wheelon exhibited a fondness and talent for art and photography and an unusual breadth of intellectual interests and knowledge. Wheelon received a bachelor's degree from the University of Washington, then studied at the University of Oregon, Northwestern University, and St. Louis University. Earning his M.D. from St. Louis University and assuming a faculty position there, Wheelon and his graduate student, Thomas, conducted widely recognized gastrointestinal research. Returning to Seattle in 1921, Wheelon became a highly respected physician and hospital administrator, but he also found time to indulge his interest in visual art and poetry. In 1933, inspired by observing a rabbit being used in a pregnancy test, Wheelon began to write and illustrate an epic, 322-page poem, Rabbit No. 202, illustrations from which became the journals' tailpieces. The present study traces Wheelon's personal life and scientific career in an attempt to understand this complex man and the origins of his unusual poem and its drawings.

  4. 12 CFR 16.16 - Effectiveness. (United States)


    ... Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY SECURITIES OFFERING DISCLOSURE RULES § 16.16 Effectiveness. (a) Registration statements and amendments filed with the OCC pursuant to this part...) and (c)) and Commission Regulation C (17 CFR part 230, Regulation C—Registration). (b) The OCC will...

  5. Native American Conference on Petroleum Energy; November 16-17, 1996; Bartlesville, Oklahoma

    Energy Technology Data Exchange (ETDEWEB)



    Thirty-three Native American tribal members, council members, and other interested parties gathered in Bartlesville, Oklahoma, to attend the Native American Conference on Petroleum Energy on October 16 and 17 1996, sponsored by the U.S. Department of Energy and BDM-Oklahoma, Inc. Tribes represented at the workshop included the Cherokee, Chickasaw, Hopi, Jicarilla Apache, Osage, Seminole, and Ute. Representatives of the Bureau of Indian Affairs (BIA), the Bureau of Land Management (BLM), and the Minerals Management Service (MMS) also attended. BDM-Oklahoma developed and organized the Native American Conference on Petroleum Energy to help meet the goals of the U.S. Department of Energy's Domestic Gas and Oil Initiative to help Native American Tribes become more self-sufficient in developing and managing petroleum resources.

  6. Towards Individualized Physiology Lecturing in Africa

    African Journals Online (AJOL)

    Dr Olaleye Samuel

    1 (1): 13 - 16. Journal of African Association of Physiological Sciences ... import from validated text format question series and seamless use of any computer program or internet .... Silverthorn D U, Human Physiology, an Integrated. Approach ...

  7. Simultaneous analysis of 17O/16O, 18O/16O and 2H/1H of gypsum hydration water by cavity ring‐down laser spectroscopy (United States)

    Mather, Ian; Rolfe, James; Evans, Nicholas P.; Herwartz, Daniel; Staubwasser, Michael; Hodell, David A.


    Rationale The recent development of cavity ring‐down laser spectroscopy (CRDS) instruments capable of measuring 17O‐excess in water has created new opportunities for studying the hydrologic cycle. Here we apply this new method to studying the triple oxygen (17O/16O, 18O/16O) and hydrogen (2H/1H) isotope ratios of gypsum hydration water (GHW), which can provide information about the conditions under which the mineral formed and subsequent post‐depositional interaction with other fluids. Methods We developed a semi‐automated procedure for extracting GHW by slowly heating the sample to 400°C in vacuo and cryogenically trapping the evolved water. The isotopic composition (δ17O, δ18O and δ2H values) of the GHW is subsequently measured by CRDS. The extraction apparatus allows the dehydration of five samples and one standard simultaneously, thereby increasing the long‐term precision and sample throughput compared with previous methods. The apparatus is also useful for distilling brines prior to isotopic analysis. A direct comparison is made between results of 17O‐excess in GHW obtained by CRDS and fluorination followed by isotope ratio mass spectrometry (IRMS) of O2. Results The long‐term analytical precision of our method of extraction and isotopic analysis of GHW by CRDS is ±0.07‰ for δ17O values, ±0.13‰ for δ18O values and ±0.49‰ for δ2H values (all ±1SD), and ±1.1‰ and ±8 per meg for the deuterium‐excess and 17O‐excess, respectively. Accurate measurement of the 17O‐excess values of GHW, of both synthetic and natural samples, requires the use of a micro‐combustion module (MCM). This accessory removes contaminants (VOCs, H2S, etc.) from the water vapour stream that interfere with the wavelengths used for spectroscopic measurement of water isotopologues. CRDS/MCM and IRMS methods yield similar isotopic results for the analysis of both synthetic and natural gypsum samples within analytical error of the two methods. Conclusions We

  8. Regulatory Physiology (United States)

    Lane, Helen W.; Whitson, Peggy A.; Putcha, Lakshmi; Baker, Ellen; Smith, Scott M.; Stewart, Karen; Gretebeck, Randall; Nimmagudda, R. R.; Schoeller, Dale A.; Davis-Street, Janis


    As noted elsewhere in this report, a central goal of the Extended Duration Orbiter Medical Project (EDOMP) was to ensure that cardiovascular and muscle function were adequate to perform an emergency egress after 16 days of spaceflight. The goals of the Regulatory Physiology component of the EDOMP were to identify and subsequently ameliorate those biochemical and nutritional factors that deplete physiological reserves or increase risk for disease, and to facilitate the development of effective muscle, exercise, and cardiovascular countermeasures. The component investigations designed to meet these goals focused on biochemical and physiological aspects of nutrition and metabolism, the risk of renal (kidney) stone formation, gastrointestinal function, and sleep in space. Investigations involved both ground-based protocols to validate proposed methods and flight studies to test those methods. Two hardware tests were also completed.

  9. Selection of mutants tolerant of oxidative stress from respiratory cultures of Lactobacillus plantarum C17. (United States)

    Zotta, T; Ianniello, R G; Guidone, A; Parente, E; Ricciardi, A


    Lactobacillus plantarum is a lactic acid bacterium involved in the production of many fermented foods. Recently, several studies have demonstrated that aerobic or respiratory metabolism in this species leads to improved technological and stress response properties. We investigated respiratory growth, metabolite production and stress resistance of Lact. plantarum C17 during batch, fed-batch and chemostat cultivations under respiratory conditions. Sixty mutants were selected for their ability to tolerate oxidative stress using H2 O2 and menadione as selective agents and further screened for their capability to growth under anaerobic, respiratory and oxidative stress conditions. Dilution rate clearly affected the physiological state of cells and, generally, slow-growing cultures had improved survival to stresses, catalase production and oxygen uptake. Most mutants were more competitive in terms of biomass production and ROS degradation compared with wild-type strain (wt) C17 and two of these (C17-m19 and C17-m58) were selected for further experiments. This work confirms that, in Lact. plantarum, respiration and low growth rates confer physiological and metabolic advantages compared with anaerobic cultivation. Our strategy of natural selection successfully provides a rapid and inexpensive screening for a large number of strains and represents a food-grade approach of practical relevance in the production of starter and probiotic cultures. © 2013 The Society for Applied Microbiology.

  10. Ácido ent-16a,17-diidroxicauran-19-óico isolado de Ouratea semiserrata e os desafios estereoquímicos dos carbonos quirais C-4 e C-16

    Directory of Open Access Journals (Sweden)

    Velandia Javier Rincón


    Full Text Available Phytochemical investigation of the leaves and branches of a specimen of Ouratea semiserrata led to the isolation and characterization of ent-16alpha,17-dihydroxykauran-19-oic acid, along with other natural products. This diterpenoid and its derivatives were used to unambiguous ¹H and 13C chemical shifts assignments and to indicate some mistake data described in the literature as consequence mainly of the stereochemicals of the chiral carbons C-4 and C-16. The HRMS spectra were also analysed.

  11. 47 CFR 90.315 - Special provisions governing use of frequencies in the 476-494 MHz band (TV Channels 15, 16, 17... (United States)


    ... in the 476-494 MHz band (TV Channels 15, 16, 17) in the Southern Louisiana-Texas Offshore Zone. 90... RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Authorization in the Band 470-512 MHz (UHF-TV Sharing) § 90.315 Special provisions governing use of frequencies in the 476-494 MHz band (TV Channels 15, 16...

  12. Galen and the beginnings of Western physiology. (United States)

    West, John B


    Galen (129-c. 216 AD) was a key figure in the early development of Western physiology. His teachings incorporated much of the ancient Greek traditions including the work of Hippocrates and Aristotle. Galen himself was a well-educated Greco-Roman physician and physiologist who at one time was a physician to the gladiators in Pergamon. Later he moved to Rome, where he was associated with the Roman emperors Marcus Aurelius and Lucius Verus. The Galenical school was responsible for voluminous writings, many of which are still extant. One emphasis was on the humors of the body, which were believed to be important in disease. Another was the cardiopulmonary system, including the belief that part of the blood from the right ventricle could enter the left through the interventricular septum. An extraordinary feature of these teachings is that they dominated thinking for some 1,300 years and became accepted as dogma by both the State and Church. One of the first anatomists to challenge the Galenical teachings was Andreas Vesalius, who produced a magnificent atlas of human anatomy in 1543. At about the same time Michael Servetus described the pulmonary transit of blood, but he was burned at the stake for heresy. Finally, with William Harvey and others in the first part of the 17th century, the beginnings of modern physiology emerged with an emphasis on hypotheses and experimental data. Nevertheless, vestiges of Galen's teaching survived into the 19th century. Copyright © 2014 the American Physiological Society.

  13. Double cascade erbium fiber laser at 1.7 µm, 2.7 µm, and 1.6 µm

    NARCIS (Netherlands)

    Schneider, J.; Frerichs, Ch.; Carbonnier, C.; Unrau, U.B.; Pollnau, Markus; Lüthy, W.; Weber, H.P.

    The output power of the erbium laser at 2.7 um (4I11/2 -> 4I13/2) is enhanced due to simultaneous laser action at 1.7 um (4S3/2 -> 4I9/2) and 1.6 um (4I13/2 -> 4I15/2) in an Er3+-doped fluorozirconate fiber. The laser cascade overwhelms the saturation effect for the transition at 2.7 um by

  14. Enhanced expression of Ang-(1-7 during pregnancy

    Directory of Open Access Journals (Sweden)

    Brosnihan K.B.


    Full Text Available Pregnancy is a physiological condition characterized by a progressive increase of the different components of the renin-angiotensin system (RAS. The physiological consequences of the stimulated RAS in normal pregnancy are incompletely understood, and even less understood is the question of how this system may be altered and contribute to the hypertensive disorders of pregnancy. Findings from our group have provided novel insights into how the RAS may contribute to the physiological condition of pregnancy by showing that pregnancy increases the expression of both the vasodilator heptapeptide of the RAS, angiotensin-(1-7 [Ang-(1-7], and of a newly cloned angiotensin converting enzyme (ACE homolog, ACE2, that shows high catalytic efficiency for Ang II metabolism to Ang-(1-7. The discovery of ACE2 adds a new dimension to the complexity of the RAS by providing a new arm that may counter-regulate the activity of the vasoconstrictor component, while amplifying the vasodilator component. The studies reviewed in this article demonstrate that Ang-(1-7 increases in plasma and urine of normal pregnant women. In preeclamptic subjects we showed that plasma Ang-(1-7 was suppressed as compared to the levels found in normal pregnancy. In addition, kidney and urinary levels of Ang-(1-7 were increased in pregnant rats coinciding with the enhanced detection and expression of ACE2. These findings support the concept that in normal pregnancy enhanced ACE2 may counteract the elevation in tissue and circulating Ang II by increasing the rate of conversion to Ang-(1-7. These findings provide a basis for the physiological role of Ang-(1-7 and ACE2 during pregnancy.

  15. The Baseplate of Lactobacillus delbrueckii Bacteriophage Ld17 Harbors a Glycerophosphodiesterase. (United States)

    Cornelissen, Anneleen; Sadovskaya, Irina; Vinogradov, Evgeny; Blangy, Stéphanie; Spinelli, Silvia; Casey, Eoghan; Mahony, Jennifer; Noben, Jean-Paul; Dal Bello, Fabio; Cambillau, Christian; van Sinderen, Douwe


    Glycerophosphodiester phosphodiesterases (GDPDs; EC typically hydrolyze glycerophosphodiesters to sn-glycerol 3-phosphate (Gro3P) and their corresponding alcohol during patho/physiological processes in bacteria and eukaryotes. GDPD(-like) domains were identified in the structural particle of bacterial viruses (bacteriophages) specifically infecting Gram-positive bacteria. The GDPD of phage 17 (Ld17; GDPDLd17), representative of the group b Lactobacillus delbrueckii subsp. bulgaricus (Ldb)-infecting bacteriophages, was shown to hydrolyze, besides the simple glycerophosphodiester, two complex surface-associated carbohydrates of the Ldb17 cell envelope: the Gro3P decoration of the major surface polysaccharide d-galactan and the oligo(glycerol phosphate) backbone of the partially glycosylated cell wall teichoic acid, a minor Ldb17 cell envelope component. Degradation of cell wall teichoic acid occurs according to an exolytic mechanism, and Gro3P substitution is presumed to be inhibitory for GDPDLd17 activity. The presence of the GDPDLd17 homotrimer in the viral baseplate structure involved in phage-host interaction together with the dependence of native GDPD activity, adsorption, and efficiency of plating of Ca(2+) ions supports a role for GDPDLd17 activity during phage adsorption and/or phage genome injection. In contrast to GDPDLd17, we could not identify any enzymatic activity for the GDPD-like domain in the neck passage structure of phage 340, a 936-type Lactococcus lactis subsp. lactis bacteriophage. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  16. Age-Related Patterns of Physical and Physiological Characteristics in Adolescent Wrestlers

    Directory of Open Access Journals (Sweden)

    Erkan Demirkan


    Full Text Available The aim of the study was to examine the physical and physiological differences as dependent on age of young wrestlers. One hundred and twenty-six 15 – 17 year old wrestlers volunteered as subjects in the present study. The physical and physiological profiles included body weight, height, body mass index, flexibility, anaerobic power, aerobic endurance, strength, speed, and body composition. The statistically significant (p<0.05 results are as follows: Age group 17 (AG 17 had significantly higher leg and arm anaerobic power and capacity (leg power: 952±216 Watt (W; arm power: 684±194 W and leg capacity: 489±101 W; arm capacity: 354±88 respectively as compared to the AG15 with (leg power: 718±279 Watt (W; arm power: 458±149 W and leg capacity: 376±132 W; arm capacity: 247±86 W respectively. AG17 wrestlers were significantly faster than AG 15 (4.29±.25 second - 4.53±.30 second respectively. AG 15 wrestlers had significantly lower right and left hand grip strength (right: 36.4±10.7 kg, left: 34.9±10 kg than AG 16 (right: 43.9±8.4kg, left: 42.5±7.8 kg and AG17 wrestlers (right: 46.6±8.7kg, left: 46.4±8.3 kg. In conclusion The results of this study suggest that height, body weight, fat free mass, arms – legs anaerobic power and capacity, speeds and hand grip strengths were increased both in one age range and in two ages range together with age progression, but it was clearly seen statistical differences in two ages range.

  17. Inhibition of transmembrane member 16A calcium-activated chloride channels by natural flavonoids contributes to flavonoid anticancer effects. (United States)

    Zhang, Xuan; Li, Honglin; Zhang, Huiran; Liu, Yani; Huo, Lifang; Jia, Zhanfeng; Xue, Yucong; Sun, Xiaorun; Zhang, Wei


    Natural flavonoids are ubiquitous in dietary plants and vegetables and have been proposed to have antiviral, antioxidant, cardiovascular protective and anticancer effects. Transmembrane member 16A (TMEM16A)-encoded Ca 2+ -activated Cl - channels play a variety of physiological roles in many organs and tissues. Overexpression of TMEM16A is also believed to be associated with cancer progression. Therefore, inhibition of TMEM16A current may be a potential target for cancer therapy. In this study, we screened a broad spectrum of flavonoids for their inhibitory activities on TMEM16A currents. A whole-cell patch technique was used to record the currents. The BrdU assay and transwell technique were used to investigate cell proliferation and migration. At a concentration of 100 μM, 10 of 20 compounds caused significant (>50%) inhibition of TMEM16A currents. The four most potent compounds - luteolin, galangin, quercetin and fisetin - had IC 50 values ranging from 4.5 to 15 μM). To examine the physiological relevance of these findings, we also studied the effects of these flavonoids on endogenous TMEM16A currents in addition to cell proliferation and migration in LA795 cancer cells. Among the flavonoids tested, we detected a highly significant correlation between TMEM16A current inhibition and cell proliferation or reduction of migration. This study demonstrates that flavonoids inhibit TMEM16A currents and suggests that flavonoids could have anticancer effects via this mechanism. © 2017 The British Pharmacological Society.

  18. Offsite Source Recovery Program (OSRP) Workshop Module: Tianjin, China, July 16-July 17, 2012

    Energy Technology Data Exchange (ETDEWEB)

    Houlton, Robert J. [Los Alamos National Laboratory


    Recovering and disposal of radioactive sources that are no longer in service in their intended capacity is an area of high concern Globally. A joint effort to recover and dispose of such sources was formed between the US Department of Energy and the Chinese Ministry of Environmental Protection (MEP), in preparation for the 2008 Beijing Olympics. LANL involvement in this agreement continues today under the DOE-Global Threat Reduction Initiative (GTRI) program. LANL will be presenting overview information on their Offsite Source Recovery (OSRP) and Source Disposal programs, in a workshop for the Ministry of Environmental Protection (MEP) at Tianjin, China, on July 16 and 17, 2012.

  19. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Pharmacology”

    Directory of Open Access Journals (Sweden)

    Various Authors


    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Pharmacology”ABS 1. BABY SKIN CARE PRODUCTS • P. Doro, R. Abraham, D. Agoston, J. Balog, R.Z. CsomaABS 2. MATHEMATICAL MODELING TO PREDICT IN-HOSPITAL NATURAL WEIGHT CHANGES IN TERM NEONATES • S. Kasser, M. Wilbaux, C. De Angelis, H. Rickenbacher, N. Klarer, J.N. Van Den Anker, M. Pfister, S. WellmannABS 3. IMPROVING PARENTERAL NUTRITION IN THE NEONATE – A PRACTICAL GUIDELINE • H. Reigstad, D. Moster, I. Grønlie, A. BlystadABS 4. INVOLUTION OF RETINOPATHY OF PREMATURITY AND NEURODEVELOPMENTAL OUTCOME AFTER BEVACIZUMAB TREATMENT • Y.-S. Chang, P.-N. Tsao, C.-Y. Chen, H.-C. Chou, W.-S. Hsieh, P.-T. YehABS 5. RELATIONSHIP BETWEEN ADVERSE DRUG REACTIONS AND OFF-LABEL/UNLICENSED DRUG USE IN HOSPITALISED CHILDREN. EREMI STUDY • K.A. Nguyen, Y. Mimouni, A. Lajoinie, N. Paret, S. Malik, L. El-Amrani, L. Milliat-Guittard, C. Carcel, A. Portefaix, A.M. Schott, T. Vial, B. KassaiABS 6. A SYSTEMATIC REVIEW OF OFF-LABEL AND UNLICENSED DRUGS USE AND ADVERSE DRUG REACTIONS IN HOSPITALIZED CHILDREN • N. David, K.A. Nguyen, Y. Mimouni, A. Lajoinie, S. Malik, B. KassaiABS 7. EFFICACY AND SAFETY OF PROPOFOL SEDATION

  20. The first joint congress of the South African Biochemical Society, South African Genetics Society and the South African Society for Microbiology at the University of the Witwatersrand, 29 June-4 July 1986

    International Nuclear Information System (INIS)


    The South African Biochemical Society, South African Genetics Society and the South African Society for Microbiology held a joint congress at the University of the Witwatersrand from 29 June - 4 July 1986. The papers delivered cover subjects such as Molecular biology, Genetics, Biochemistry, Medical biochemistry, Physiology, Zoology and Isotope and radiation sciences. Different isotopes are used in labelling studies of enzymes, nutrition, metabolism, viruses, bacteria and other biological assays done in the fields of Biochenmistry, Genetics and Microbiology. This work contains only the abstracts of these papers

  1. Difference flow measurements and hydraulic interference test in ONKALO at Olkiluoto drillholes ONK-PH16 and ONK-PH17

    Energy Technology Data Exchange (ETDEWEB)

    Komulainen, J.; Pekkanen, J. [Poyry Finland Oy, Espoo (Finland)


    The Posiva Flow Log, Difference Flow Method (PFL DIFF) uses a flowmeter that incorporates a flow guide and can be used for relatively quick determinations of hydraulic conductivity and hydraulic head in fractures/fractured zones in cored drillholes. This report presents the principles of the method as well as the results of the measurements carried out in the underground facilities of ONKALO. The measurements were conducted in pilot holes ONK-PH16 and ONK-PH17 between October 12 and December 29, 2010. The aim of the measurements was to detect water conducting fractures and hydraulic interference between pilot holes ONK-PH16 and ONK-PH17. The flow rate into a 0.5 m long test section was measured using 0.1 m point intervals. The flowing fractures in both pilot holes were obtained between 50 m - 80 m. For hydraulic interference test one drillhole was closed with packers to increase its pressure. Flow response to the increased pressure was measured in the other drillhole. The flow guide of the PFL DIFF probe encloses an electrode for single point resistance measurement, which was carried out with 0.01 m point intervals during the automatic flow measurements. The flow measurement and the single point resistance measurement were used to locate flowing fractures and evaluate their transmissivity. Electrical conductivity (EC) and temperature of water were registered during automatic flow logging. The conductivity values are temperature corrected to 25 deg C. The distance between the drillholes is about 14 m. Flow response in fractures of open ONK-PH16 could be detected when pressure was changed in ONK-PH17. (orig.)

  2. β1 subunit stabilises sodium channel Nav1.7 against mechanical stress. (United States)

    Körner, Jannis; Meents, Jannis; Machtens, Jan-Philipp; Lampert, Angelika


    modified by interfering with the extracellular end of segment 6 of domain IV. Thus, our data suggest that physiological gating of Nav1.7 may be protected against mechanical stress in a living organism by assembly with the β1 subunit. © 2018 The Authors. The Journal of Physiology © 2018 The Physiological Society.

  3. Melanoma devitalization induces T cell anti-tumour immunity in the MeLiM miniature pigs

    Czech Academy of Sciences Publication Activity Database

    Horák, Vratislav; Soukupová, Pavla; Šinkora, J.; Řeháková, Z.; Veselský, Leopold; Málek, Ondřej; Hradecký, Jan; Klaudy, Jiří


    Roč. 16, č. 5 (2003), s. 583 ISSN 0893-5785. [Meeting of the European Society for Pigment Cell Research/11./. 17.09.2003-20.09.2003, Gent] R&D Projects: GA ČR GA524/01/0162; GA AV ČR IBS5045113 Institutional research plan: CEZ:AV0Z5052915; CEZ:AV0Z5045916 Keywords : devitalization Subject RIV: ED - Physiology

  4. Searching for Women in Korean Scientific Societies

    Indian Academy of Sciences (India)


    III. Female Participation in S&E Societies. 16. ▫ the Committee for Women in KOFST (the Korean Federation of Science and Technology Societies) in 2012. Size of Responding Societies. ▫. Monitored gender ratio of committee members of its member societies in. Science and engineering. 52. 60. 80. 100. 120. Total Number.

  5. Join the CERN ISEF special award winners | 16 June - 3 p.m.

    CERN Document Server


    Come and join the CERN ISEF special award winners at their lightning talks session on 16 June at 3.00 p.m. in the main auditorium.   The 2016 Intel ISEF CERN special award winners on stage with the selection committee on 17 May 2016 in Phoenix, Arizona, USA. (Picture: Society for Science and the Public) Between 11 and 17 June 2016, the ten finalists of the Intel International Science and Engineering Fair (ISEF) who won the CERN Special Award, will visit CERN to partake in various educational lectures. ISEF is the world's largest international pre-college science competition, with approximately 1,700 high school students from more than 75 countries taking part. They will present their projects in short 5 minutes lightning talks' sessions at the main auditorium on Thursday 16 June at 3 p.m. The award winners would be also very happy to have a chance to interact and discuss with you af...

  6. Die noodsaak van kulturele interaksie in Apologetiek: Handelinge 17:16-32 as motivering

    Directory of Open Access Journals (Sweden)

    Johan Erasmus


    Full Text Available The need of cultural interaction in Apologetics: Acts 17:16–32 as explanatory statement. Acceptance of a secular-versus-holy dualism holds Christianity in a cultural prison and has the effect that the Christian faith becomes a compartmentalised entity, which oddly fits in a secular context, because it does not have an impact outside the church building. To be culturally effective in its communication, apologetics should make use of images and expressions that is known by the people it aims to reach. Interacting with their worldviews in a narrative form is also much more subtle than the use of an argumentative style of reasoning that emphasise differences. Arts have a particular ability to shape and analyse culture. Films can help Christian apologists to understand culture as well as to be in a better position to engage meaningfully with the world. In a similar way to which Paul made use of pagan insights and narratives in Acts 17, the themes of contemporary movies can be used by apologists. Paul’s strategy was not the syncretistic reconciliation of two incompatible worldviews, but subversion through giving Greek ideas new meaning by placing them in a monotheistic context. When apologetics makes use of stories saturated with Christian themes, it can address secular imagination with an understanding of God and the world which they would not otherwise have considered.

  7. Antioxidant protection of LDL by physiological concentrations of 17 beta-estradiol. Requirement for estradiol modification. (United States)

    Shwaery, G T; Vita, J A; Keaney, J F


    Exposure to estrogens reduces the risk for coronary artery disease and associated clinical events; however, the mechanisms responsible for these observations are not clear. Supraphysiological levels of estrogens act as antioxidants in vitro, limiting oxidation of low-density lipoprotein (LDL), an event implicated in atherogenesis. We investigated the conditions under which physiological concentrations of 17 beta-estradiol (E2) inhibit oxidative modification of LDL. Plasma incubated with E2 (0.1 to 100 nmol/L) for 4 hours yielded LDL that demonstrated a dose-related increase in resistance to oxidation by Cu2+ as measured by conjugated diene formation. This effect was dependent on plasma, because incubation of isolated LDL with E2 at these concentrations in buffered saline produced no effect on Cu(2+)-mediated oxidation. Incubation of plasma with E2 had no effect on LDL alpha-tocopherol content or cholesteryl ester hydroperoxide formation during the 4-hour incubation. Plasma incubation with [3H]E2 was associated with dose-dependent association of 3H with LDL. High-performance liquid chromatographic analysis of LDL derived from plasma incubated with [3H]E2 indicated that the majority of the associated species were not detectable as authentic E2 but as nonpolar forms of E2 that were susceptible to base hydrolysis consistent with fatty acid esterification of E2. Plasma-mediated association of E2 and subsequent antioxidant protection was inhibited by 5,5'-dithiobis(2-nitrobenzoic acid), an inhibitor of plasma acyltransferase activity. Exposure of LDL to physiological levels of E2 in a plasma milieu is associated with enhanced resistance to Cu(2+)-mediated oxidation and incorporation of E2 derivatives into LDL. This antioxidant capacity may be another means by which E2 limits coronary artery disease in women.

  8. OSCAR experiment high-density network data report: Event 3 - April 16-17, 1981

    Energy Technology Data Exchange (ETDEWEB)

    Dana, M.T.; Easter, R.C.; Thorp, J.M.


    The OSCAR (Oxidation and Scavenging Characteristics of April Rains) experiment, conducted during April 1981, was a cooperative field investigation of wet removal in cyclonic storm systems. The high-density component of OSCAR was located in northeast Indiana and included sequential precipitation chemistry measurements on a 100 by 100 km network, as well as airborne air chemistry and cloud chemistry measurements, surface air chemistry measurements, and supporting meteorological measurements. Four separate storm events were studied during the experiment. This report summarizes data taken by Pacific Northwest Laboratory (PNL) during the third storm event, April 16-17. The report contains the high-density network precipitation chemistry data, air chemistry and cloud chemistry data from the PNL aircraft, and meteorological data for the event, including standard National Weather Service products and radar and rawindsonde data from the network. 4 references, 76 figures, 6 tables.

  9. Proceedings of the International Association for Development of the Information Society (IADIS) International Conference on Mobile Learning (Lisbon, Portugal, March 14-16, 2013) (United States)

    Sánchez, Inmaculada Arnedillo, Ed.; Isaías, Pedro, Ed.


    These proceedings contain the papers of the International Conference on Mobile Learning 2013, which was organised by the International Association for Development of the Information Society, in Lisbon, Portugal, March 14-16, 2013. The Mobile Learning 2013 International Conference seeks to provide a forum for the presentation and discussion of…

  10. Control of ADAM17 activity by regulation of its cellular localisation (United States)

    Lorenzen, Inken; Lokau, Juliane; Korpys, Yvonne; Oldefest, Mirja; Flynn, Charlotte M.; Künzel, Ulrike; Garbers, Christoph; Freeman, Matthew; Grötzinger, Joachim; Düsterhöft, Stefan


    An important, irreversible step in many signalling pathways is the shedding of membrane-anchored proteins. A Disintegrin And Metalloproteinase (ADAM) 17 is one of the major sheddases involved in a variety of physiological and pathophysiological processes including regeneration, differentiation, and cancer progression. This central role in signalling implies that ADAM17 activity has to be tightly regulated, including at the level of localisation. Most mature ADAM17 is localised intracellularly, with only a small amount at the cell surface. We found that ADAM17 is constitutively internalised by clathrin-coated pits and that physiological stimulators such as GPCR ligands induce ADAM17-mediated shedding, but do not alter the cell-surface abundance of the protease. In contrast, the PKC-activating phorbol ester PMA, often used as a strong inducer of ADAM17, causes not only proteolysis by ADAM17 but also a rapid increase of the mature protease at the cell surface. This is followed by internalisation and subsequent degradation of the protease. Eventually, this leads to a substantial downregulation of mature ADAM17. Our results therefore imply that physiological activation of ADAM17 does not rely on its relocalisation, but that PMA-induced PKC activity drastically dysregulates the localisation of ADAM17. PMID:27731361

  11. Occupational physiology

    CERN Document Server

    Toomingas, Allan; Tornqvist, Ewa Wigaeus


    In a clear and accessible presentation, Occupational Physiology focuses on important issues in the modern working world. Exploring major public health problems-such as musculoskeletal disorders and stress-this book explains connections between work, well-being, and health based on up-to-date research in the field. It provides useful methods for risk assessment and guidelines on arranging a good working life from the perspective of the working individual, the company, and society as a whole.The book focuses on common, stressful situations in different professions. Reviewing bodily demands and r


    International Nuclear Information System (INIS)

    Smith, Rachel L.; Young, Edward D.; Pontoppidan, Klaus M.; Morris, Mark R.; Van Dishoeck, Ewine F.


    Using very high resolution (λ/Δλ ∼ 95 000) 4.7 μm fundamental and 2.3 μm overtone rovibrational CO absorption spectra obtained with the Cryogenic Infrared Echelle Spectrograph infrared spectrometer on the Very Large Telescope (VLT), we report detections of four CO isotopologues-C 16 O, 13 CO, C 18 O, and the rare species, C 17 O-in the circumstellar environment of two young protostars: VV CrA, a binary T Tauri star in the Corona Australis molecular cloud, and Reipurth 50, an intermediate-mass FU Ori star in the Orion Molecular Cloud. We argue that the observed CO absorption lines probe a protoplanetary disk in VV CrA, and a protostellar envelope in Reipurth 50. All CO line profiles are spectrally resolved, with intrinsic line widths of ∼3-4 km s -1 (FWHM), permitting direct calculation of CO oxygen isotopologue ratios with 5%-10% accuracy. The rovibrational level populations for all species can be reproduced by assuming that CO absorption arises in two temperature regimes. In the higher temperature regime, in which the column densities are best determined, the derived oxygen isotope ratios in VV CrA are: [C 16 O]/[C 18 O] =690 ± 30; [C 16 O]/[C 17 O] =2800 ± 300, and [C 18 O]/[C 17 O]=4.1 ± 0.4. For Reipurth 50, we find [C 16 O]/[C 18 O] =490 ± 30; [C 16 O]/[C 17 O] =2200 ± 150, [C 18 O]/[C 17 O] = 4.4 ± 0.2. For both objects, 12 C/ 13 C are on the order of 100, nearly twice the expected interstellar medium (ISM) ratio. The derived oxygen abundance ratios for the VV CrA disk show a significant mass-independent deficit of C 17 O and C 18 O relative to C 16 O compared to ISM baseline abundances. The Reipurth 50 envelope shows no clear differences in oxygen CO isotopologue ratios compared with the local ISM. A mass-independent fractionation can be interpreted as being due to selective photodissociation of CO in the disk surface due to self-shielding. The deficits in C 17 O and C 18 O in the VV CrA protoplanetary disk are consistent with an analogous

  13. High precision measurements of 16O12C17O using a new type of cavity ring down spectrometer (United States)

    Daëron, M.; Stoltmann, T.; Kassi, S.; Burkhart, J.; Kerstel, E.


    Laser absorption techniques for the measurement of isotopologue abundances in gases have been dripping into the geoscientific community over the past decade. In the field of carbon dioxide such instruments have mostly been restricted to measurements of the most abundant stable isotopologues. Distinct advantages of CRDS techniques are non-destructiveness and the ability to resolve isobaric isotopologues. The determination of low-abundance isotopologues is predominantly limited by the linewidth of the probing laser, laser jitter, laser drift and system stability. Here we present first measurements of 16O12C17O abundances using a new type of ultra-precise cavity ring down spectrometer. By the use of Optical Feedback Frequency Stabilization, we achieved a laser line width in the sub-kHz regime with a frequency drift of less than 20 Hz/s. A tight coupling with an ultra-stable ring down cavity combined with a frequency tuning mechanism which enables us to arbitrarily position spectral points (Burkart et al., 2013) allowed us to demonstrate a single-scan (2 minutes) precision of 40 ppm on the determination of the 16O12C17O abundance. These promising results imply that routine, direct, high-precision measurements of 17O-anomalies in CO2 using this non-destructive method are in reach. References:Burkart J, Romanini D, Kassi S; Optical feedback stabilized laser tuned by single-sideband modulation; Optical Letters 12:2062-2063 (2013)

  14. Physiological integration enhanced the tolerance of Cynodon dactylon to flooding. (United States)

    Li, Z J; Fan, D Y; Chen, F Q; Yuan, Q Y; Chow, W S; Xie, Z Q


    Many flooding-tolerant species are clonal plants; however, the effects of physiological integration on plant responses to flooding have received limited attention. We hypothesise that flooding can trigger changes in metabolism of carbohydrates and ROS (reactive oxygen species) in clonal plants, and that physiological integration can ameliorate the adverse effects of stress, subsequently restoring the growth of flooded ramets. In the present study, we conducted a factorial experiment combining flooding to apical ramets and stolon severing (preventing physiological integration) between apical and basal ramets of Cynodon dactylon, which is a stoloniferous perennial grass with considerable flooding tolerance. Flooding-induced responses including decreased root biomass, accumulation of soluble sugar and starch, as well as increased activity of superoxide dismutase (SOD) and ascorbate peroxidase (APX) in apical ramets. Physiological integration relieved growth inhibition, carbohydrate accumulation and induction of antioxidant enzyme activity in stressed ramets, as expected, without any observable cost in unstressed ramets. We speculate that relief of flooding stress in clonal plants may rely on oxidising power and electron acceptors transferred between ramets through physiological integration. © 2014 German Botanical Society and The Royal Botanical Society of the Netherlands.

  15. 17 CFR 248.16 - Protection of Fair Credit Reporting Act. (United States)


    ... Reporting Act. 248.16 Section 248.16 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-P: Privacy of Consumer Financial Information and Safeguarding Personal Information Relation to Other Laws; Effective Date § 248.16 Protection of Fair Credit...

  16. 17 CFR 240.16b-7 - Mergers, reclassifications, and consolidations. (United States)


    ... financial statements for a 12 month period before the merger, reclassification or consolidation, or such..., and consolidations. 240.16b-7 Section 240.16b-7 Commodity and Securities Exchanges SECURITIES AND...) § 240.16b-7 Mergers, reclassifications, and consolidations. (a) The following transactions shall be...

  17. Using measures of single-cell physiology and physiological state to understand organismic aging. (United States)

    Mendenhall, Alexander; Driscoll, Monica; Brent, Roger


    Genetically identical organisms in homogeneous environments have different lifespans and healthspans. These differences are often attributed to stochastic events, such as mutations and 'epimutations', changes in DNA methylation and chromatin that change gene function and expression. But work in the last 10 years has revealed differences in lifespan- and health-related phenotypes that are not caused by lasting changes in DNA or identified by modifications to DNA or chromatin. This work has demonstrated persistent differences in single-cell and whole-organism physiological states operationally defined by values of reporter gene signals in living cells. While some single-cell states, for example, responses to oxygen deprivation, were defined previously, others, such as a generally heightened ability to make proteins, were, revealed by direct experiment only recently, and are not well understood. Here, we review technical progress that promises to greatly increase the number of these measurable single-cell physiological variables and measureable states. We discuss concepts that facilitate use of single-cell measurements to provide insight into physiological states and state transitions. We assert that researchers will use this information to relate cell level physiological readouts to whole-organism outcomes, to stratify aging populations into groups based on different physiologies, to define biomarkers predictive of outcomes, and to shed light on the molecular processes that bring about different individual physiologies. For these reasons, quantitative study of single-cell physiological variables and state transitions should provide a valuable complement to genetic and molecular explanations of how organisms age. © 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

  18. Successful linking of the Society of Thoracic Surgeons Database to Social Security data to examine the accuracy of Society of Thoracic Surgeons mortality data. (United States)

    Jacobs, Jeffrey P; O'Brien, Sean M; Shahian, David M; Edwards, Fred H; Badhwar, Vinay; Dokholyan, Rachel S; Sanchez, Juan A; Morales, David L; Prager, Richard L; Wright, Cameron D; Puskas, John D; Gammie, James S; Haan, Constance K; George, Kristopher M; Sheng, Shubin; Peterson, Eric D; Shewan, Cynthia M; Han, Jane M; Bongiorno, Phillip A; Yohe, Courtney; Williams, William G; Mayer, John E; Grover, Frederick L


    The Society of Thoracic Surgeons Adult Cardiac Surgery Database has been linked to the Social Security Death Master File to verify "life status" and evaluate long-term surgical outcomes. The objective of this study is explore practical applications of the linkage of the Society of Thoracic Surgeons Adult Cardiac Surgery Database to Social Securtiy Death Master File, including the use of the Social Securtiy Death Master File to examine the accuracy of the Society of Thoracic Surgeons 30-day mortality data. On January 1, 2008, the Society of Thoracic Surgeons Adult Cardiac Surgery Database began collecting Social Security numbers in its new version 2.61. This study includes all Society of Thoracic Surgeons Adult Cardiac Surgery Database records for operations with nonmissing Social Security numbers between January 1, 2008, and December 31, 2010, inclusive. To match records between the Society of Thoracic Surgeons Adult Cardiac Surgery Database and the Social Security Death Master File, we used a combined probabilistic and deterministic matching rule with reported high sensitivity and nearly perfect specificity. Between January 1, 2008, and December 31, 2010, the Society of Thoracic Surgeons Adult Cardiac Surgery Database collected data for 870,406 operations. Social Security numbers were available for 541,953 operations and unavailable for 328,453 operations. According to the Society of Thoracic Surgeons Adult Cardiac Surgery Database, the 30-day mortality rate was 17,757/541,953 = 3.3%. Linkage to the Social Security Death Master File identified 16,565 cases of suspected 30-day deaths (3.1%). Of these, 14,983 were recorded as 30-day deaths in the Society of Thoracic Surgeons database (relative sensitivity = 90.4%). Relative sensitivity was 98.8% (12,863/13,014) for suspected 30-day deaths occurring before discharge and 59.7% (2120/3551) for suspected 30-day deaths occurring after discharge. Linkage to the Social Security Death Master File confirms the accuracy of

  19. Home geriatric physiological measurements. (United States)

    Tamura, Toshiyo


    In an ageing society, the elderly can be monitored with numerous physiological, physical and passive devices. Sensors can be installed in the home for continuous mobility assistance and unobtrusive disease prevention. This review presents several modern sensors, which improve the quality of life and assist the elderly, disabled people and their caregivers. The main concept of geriatric sensors is that they are capable of providing assistance without limiting or disturbing the subject's daily routine, giving him or her greater comfort, pleasure and well-being. Furthermore, this review includes associated technologies of wearable/implantable monitoring systems and the 'smart-house' project. This review concludes by discussing future challenges of the future aged society.

  20. Home geriatric physiological measurements

    International Nuclear Information System (INIS)

    Tamura, Toshiyo


    In an ageing society, the elderly can be monitored with numerous physiological, physical and passive devices. Sensors can be installed in the home for continuous mobility assistance and unobtrusive disease prevention. This review presents several modern sensors, which improve the quality of life and assist the elderly, disabled people and their caregivers. The main concept of geriatric sensors is that they are capable of providing assistance without limiting or disturbing the subject's daily routine, giving him or her greater comfort, pleasure and well-being. Furthermore, this review includes associated technologies of wearable/implantable monitoring systems and the ‘smart-house’ project. This review concludes by discussing future challenges of the future aged society. (topical review)

  1. Begeleid rijden: wie doet mee met 2toDrive en waarom? : een vragenlijstonderzoek onder 16- en 17-jarigen in Nederland.

    NARCIS (Netherlands)

    Schagen, I.N.L.G. van Wijlhuizen, G.J. & Craen, S. de


    Accompanied driving: who participate in 2toDrive and why? : a questionnaire study among 16 and 17-year-olds in the Netherlands. On 1 November 2011, 2toDrive, a six-year pilot of accompanied driving, commenced in the Netherlands. In 2toDrive youths can start their driver training and take the theory

  2. A Long Journey from Childhood to Senility: The 23rd HUPO BPP Workshop: 16-17 April 2015, São Paulo, Brazil. (United States)

    Magraoui, Fouzi El; Schrötter, Andreas; Heinsen, Helmut; Leite, Renata; Park, Young Mok; Meyer, Helmut E; Grinberg, Lea T


    The HUPO Brain Proteome Project (HUPO BPP) held its 23rd workshop in São Paulo, Brazil, April 16-17, 2015. The focus of the spring workshop was on strategies and predictive therapies concerning neurodegenerative diseases. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. MRI of the wrist is not recommended for age determination in female football players of U-16/U-17 competitions. (United States)

    Tscholl, P M; Junge, A; Dvorak, J; Zubler, V


    Age determination on magnetic resonance imaging (MRI) of the wrist is a reliable method in male football players to evaluate their eligibility to participate in Under 17 tournaments. MRI of the wrist was performed in 487 female volunteers aged 13-19 years from Brazil, Germany, Malaysia, and Tanzania, and in 139 female football players participating in Under-16 and Under-17 football tournaments. A previously validated method for grading fusion of the distal radial epiphysis in male adolescent was used. Moderate correlation of chronological age and epiphyseal fusion was found in the normative control group (r = .59) and weak correlation in female football players (r = .27). Complete fusion of the distal radial epiphysis was observed in two 15-year-old volunteers of the control group (1.7%) and in 17.6% (3 of 17) of 14-year-old football players. Up to 10.8% (47 of 437) in the control group and 14.4% (20 of 139) of the football players 17 years or younger had complete fused epiphysis. Because of earlier osseous maturity in female adolescents, the grade of fusion of the distal radial epiphysis on MRI is not recommended for pretournament age determination for the age of 17 and younger in female. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  4. Effects of refrigerating preinoculated Vitek cards on microbial physiology and antibiotic susceptibility (United States)

    Skweres, Joyce A.; Bassinger, Virginia J.; Mishra, S. K.; Pierson, Duane L.


    Reference cultures of 16 microorganisms obtained from the American Type Culture Collection and four clinical isolates were used in standardized solutions to inoculate 60 cards for each test strain. A set of three ID and three susceptibility cards was processed in the Vitek AutoMicrobic System (AMS) immediately after inoculation. The remaining cards were refrigerated at 4 C, and sets of six cards were removed and processed periodically for up to 17 days. The preinoculated AMS cards were evaluated for microorganism identification, percent probability of correct identification, length of time required for final result, individual substrate reactions, and antibiotic minimal inhibitory/concentration (MIC) values. Results indicate that 11 of the 20 microbes tested withstood refrigerated storage up to 17 days without detectable changes in delineating characteristics. MIC results appear variable, but certain antibiotics proved to be more stable than others. The results of these exploratory studies will be used to plan a microgravity experiment designed to study the effect of microgravity on microbial physiology and antibiotic sensitivity.

  5. Measurement of the D/H, 18O/16O, and 17O/16O Isotope Ratios in Water by Laser Absorption Spectroscopy at 2.73 μm

    Directory of Open Access Journals (Sweden)

    Tao Wu


    Full Text Available A compact isotope ratio laser spectrometry (IRLS instrument was developed for simultaneous measurements of the D/H, 18O/16O and 17O/16O isotope ratios in water by laser absorption spectroscopy at 2.73 μm. Special attention is paid to the spectral data processing and implementation of a Kalman adaptive filtering to improve the measurement precision. Reduction of up to 3-fold in standard deviation in isotope ratio determination was obtained by the use of a Fourier filtering to remove undulation structure from spectrum baseline. Application of Kalman filtering enables isotope ratio measurement at 1 s time intervals with a precision (<1‰ better than that obtained by conventional 30 s averaging, while maintaining a fast system response. The implementation of the filter is described in detail and its effects on the accuracy and the precision of the isotope ratio measurements are investigated.

  6. Advanced Physiological Estimation of Cognitive Status. Part 2 (United States)


    fatigue, overload) Technology Transfer Opportunity Technology from PDT – Methods to acquire various physiological signals (EEG, EOG , EMG, ECG, etc...Integrated Hardware for Experiments EEG Sensor Array EOG Sensor Array Eye Tracker Amplifiers and Signal Conditioners Laptop Computer...REPORT Advanced Physiological Estimation of Cognitive Status - Part II 14. ABSTRACT 16. SECURITY CLASSIFICATION OF: This report describes ongoing work

  7. Growth and Physiology of Senegalia senegal (L. Britton Seedlings as Influenced by Seed Origin and Salinity and Fertility Treatments

    Directory of Open Access Journals (Sweden)

    Mame Sokhna Sarr


    Full Text Available Multipurpose trees such as Senegalia senegal are widespread in arid and semi-arid lands that have natural or induced saline soils and poor soil fertility. Such environmental problems impact growth and have the potential to influence plant physiological adaptations. Identifying superior genotypes better adapted to these environmental stresses will be of great importance for tree selection for reclamation of degraded drylands. The main objective of this study was to examine the growth performance, and physiological and morphological adaptations to salinity, and fertility treatments of different Senegalia senegal families. We used five families (DB16, DB14, K4B19, K17B19, NB1 selected from 60 families of a Senegalia senegal progeny trial in Dahra, Senegal. Seedlings were grown under greenhouse conditions by watering all plants for three weeks and then stopping all watering for three more weeks. In a randomized complete block design, a two-level factorial combination was used for salinity (zero and 183.1 mM NaCl added and fertility (zero and 100 kg/ha N-P-K added treatments. A significant family × salt × fertilizer interaction was found for all biomass parameters (leaf dry matter, stem dry matter, root dry matter, and leaf area. The fertilizer application resulted in a significant increase of total biomass of all families, ranging from 63% to 237% for NB1 and K17B19, respectively. In contrast, salt only decreased total biomass of NB1 and K17B19 increased growth. Despite similar net photosynthetic rates before treatment started, fertilizer and salinity induced different effects between families. Prior to drought stress, fertilizer did not affect photosynthesis of DB16, while salt significantly decreased stomatal conductance of all families. DB16 and N1B1, despite significant differences of stomata size and density, significantly decreased transpiration, and thereby increased their intrinsic water use efficiency. Under drought, relative growth rate

  8. Proceedings of the International Association for Development of the Information Society (IADIS) International Conference on Mobile Learning (11th, Madeira, Portugal, March 14-16, 2015) (United States)

    Sánchez, Inmaculada Arnedillo, Ed.; Isaías, Pedro, Ed.


    These proceedings contain the papers and posters of the 11th International Conference on Mobile Learning 2015, which was organised by the International Association for Development of the Information Society, in Madeira, Portugal, March 14-16, 2015. The Mobile Learning 2015 Conference seeks to provide a forum for the presentation and discussion of…

  9. Produksi Ruang Kekuasaan di Pulau Jawa Abad ke-16-17 dan Dampaknya pada Pertumbuhan Kota

    Directory of Open Access Journals (Sweden)

    Hafid Setiadi


    Full Text Available Abstrak Studi ini membahas keterkaitan antara tradisi kekuasaan, produksi ruang, dan pertumbuhan kota. Tujuan utamanya adalah untuk memahami secara mendalam pola dan proses spasial produksi ruang kekuasaan dan implikasinya pada pertumbuhan kota. Lingkup penelitian mencakup situasi geopolitik di Pulau Jawa selama abad ke-16 hingga ke-17 ketika Kesultanan Mataram memegang dominasi kekuasaan berlandaskan tradisi sawah. Metode analisis yang diterapkan mengacu pada pemikiran hermeneutika yang mengedepankan metode pembacaan teks. Data penelitian berasal dari sumber-sumber sekunder terutama berupa hasil-hasil penelitian yang telah dipublikasikan dalam bentuk artikel, buku, peta maupun makalah seminar.  Hasil analisis memperlihatkan bahwa selama rentang waktu tersebut pola dan proses spasial produksi ruang kekuasaan didominasi oleh netralisasi dan pembentukan wilayah pinggiran sebagai konsekuensi dari absolutisme kekuasaan raja.  Modus produksi ini menyebabkan terjadinya likuidasi politik terhadap kota-kota tertentu yang ditandai oleh perubahan identitas kota, terutama di wilayah pesisir.   Abstract This study discusses the relations between the tradition of power, the production of space, and city growth. This study primarily aimed to comprehend the spatial pattern and process of the production of authority space and its implications for city growth. It covers the geopolitical situation in Java during the 16th and 17th centuries when the Mataram Sultanate ran a dominant power based on ricefield tradition. The analysis method applied in this study referred to hermeneutical thinking, which foregrounds a text reading method. The research data was obtained from secondary resources, especially published research in the forms of articles, books, maps, and seminar papers. The analysis results showed that the spatial pattern and process of authority space production within these centuries were dominated by neutralization and the formation of peripheries, i

  10. Automatic synthesis of 16α-[18F]fluoro-17β-estradiol using a cassette-type [18F]fluorodeoxyglucose synthesizer

    International Nuclear Information System (INIS)

    Mori, Tetsuya; Kasamatsu, Shingo; Mosdzianowski, Christoph; Welch, Michael J.; Yonekura, Yoshiharu; Fujibayashi, Yasuhisa


    16α-[ 18 F]fluoro-17β-estradiol ([ 18 F]FES) is a radiotracer for imaging estrogen receptors by positron emission tomography. We developed a clinically applicable automatic preparation system for [ 18 F]FES by modifying a cassette-type [ 18 F]fluorodeoxyglucose synthesizer. Two milligrams of 3-O-methoxymethyl-16,17-O-sulfuryl-16-epiestriol in acetonitrile was heated at 105 o C for 10 min with dried [ 18 F]fluoride. The resultant solution was evaporated and hydrolyzed with 0.2 N HCl in 90% acetonitrile/water at 95 o C for 10 min under pressurized condition. The neutralization was carried out with 2.8% NaHCO 3 , and then the high-performance liquid chromatography (HPLC) purification was performed. The desired radioactive fraction was collected and the solvent was replaced by 10 ml of saline, and then passed through a 0.22-μm filter into a pyrogen-free vial as the final product. The HPLC purification data demonstrated that [ 18 F]FES was synthesized with a yield of 76.4±1.9% (n=5). The yield as the final product for clinical use was 42.4±3.2% (n=5, decay corrected). The total preparation time was 88.2±6.4 min, including the HPLC purification and the solvent replacement process. The radiochemical purity of the final product was >99%, and the specific activity was more than 111 GBq/μmol. The final product was stable for more than 6 h in saline containing sodium ascorbate. This new preparation system enables us to produce [ 18 F]FES safe for clinical use with high and reproducible yield

  11. Myths and Truths from Exercise Physiology (United States)

    Kieffer, H. Scott


    This article addresses some of the common myths in the field of exercise physiology. Some of the myths are misconstrued facts that have developed over time, such as the myth of localized fat reduction. Other myths are unproved or collective beliefs used to justify a social institution; we see this occur in the form of "fitness fads." Society is…

  12. The XIIIth International Physiological Congress in Boston in 1929: American physiology comes of age. (United States)

    Rall, Jack A


    In the 19th century, the concept of experimental physiology originated in France with Claude Bernard, evolved in Germany stimulated by the teaching of Carl Ludwig, and later spread to Britain and then to the United States. The goal was to develop a physicochemical understanding of physiological phenomena. The first International Physiological Congress occurred in 1889 in Switzerland with an emphasis on experimental demonstrations. The XIIIth Congress, the first to be held outside of Europe, took place in Boston, MA, in 1929. It was a watershed meeting and indicated that American physiology had come of age. Meticulously organized, it was the largest congress to date, with over 1,200 participants from more than 40 countries. Getting to the congress was a cultural adventure, especially for the 400 scientists and their families from over 20 European countries, who sailed for 10 days on the S.S. Minnekahda. Many of the great physiologists of the world were in attendance, including 22 scientists who were either or would become Nobel Laureates. There were hundreds of platform presentations and many experimental demonstrations. The meeting was not without controversy as a conflict, still not completely settled, arose over the discovery of ATP. After the meeting, hundreds of participants made a memorable trip to the Marine Biological Laboratory at Woods Hole, MA, which culminated in a "good old fashioned Cape Cod Clambake." Although not as spectacular as the 1929 congress, the physiological congresses have continued with goals similar to those established more than a century ago. Copyright © 2016 The American Physiological Society.

  13. Proton angular distribution of {sup 16}O(d,p){sup 17}O{sup *} near a deuteron capture resonance; Evolution de la distribution angulaire des protons {sup 16}O(d,p){sup 17}O{sup *} au voisinage d'une resonance de capture du deuteron

    Energy Technology Data Exchange (ETDEWEB)

    Berthelot, R; Cohen, E; Cotton, H; Farraggi, T; Grjebine, A; Leveque, V; Naggiar, M; Roclawski-Conjeaud, D; Szteinsznaider, D [Commissariat a l' Energie Atomique, Saclay(France). Centre d' Etudes Nucleaires


    The study of angular distributions of the protons from the reaction {sup 16}O(d,p){sup 17}O{sup *} (level at 875 keV) was made, using a photographic method, at seven different deuteron energies, from 1.66 to 2.20 MeV (obtained with the Saclay electrostatic generator). The analysis of results shows that the angular distribution for forward angles is for each chosen energy in good agreement with the stripping theory (l = 0), even at the maximum of the capture resonance of the deuteron, about 2.1 MeV. Moreover, the differential cross section at 7 deg reaches a maximum for this resonance energy. (author) [French] L'etude des distributions angulaires des protons emis au cours de la reaction {sup 16}O(d,p){sup 17}O{sup *} (niveau a 875 key) a ete effectuee, par une methode photographique, pour 7 energies differentes de deuterons comprises entre 1,66 et 2,20 MeV (obtenues grace a l'accelerateur electrostatique de Saclay). L'analyse des resultats montre que la distribution angulaire vers l'avant est, pour toutes ces energies, en bon accord avec la theorie du ''stripping'' ( 1=0), meme au maximum de la resonance de capture du deuteron situee vers 2,1 MeV. De plus, la section efficace differentielle a 7 deg passe par un maximum pour cette energie de resonance. (auteur)

  14. Severity scores in trauma patients admitted to ICU. Physiological and anatomic models. (United States)

    Serviá, L; Badia, M; Montserrat, N; Trujillano, J


    The goals of this project were to compare both the anatomic and physiologic severity scores in trauma patients admitted to intensive care unit (ICU), and to elaborate mixed statistical models to improve the precision of the scores. A prospective study of cohorts. The combined medical/surgical ICU in a secondary university hospital. Seven hundred and eighty trauma patients admitted to ICU older than 16 years of age. Anatomic models (ISS and NISS) were compared and combined with physiological models (T-RTS, APACHE II [APII], and MPM II). The probability of death was calculated following the TRISS method. The discrimination was assessed using ROC curves (ABC [CI 95%]), and the calibration using the Hosmer-Lemeshoẃs H test. The mixed models were elaborated with the tree classification method type Chi Square Automatic Interaction Detection. A 14% global mortality was recorded. The physiological models presented the best discrimination values (APII of 0.87 [0.84-0.90]). All models were affected by bad calibration (P<.01). The best mixed model resulted from the combination of APII and ISS (0.88 [0.83-0.90]). This model was able to differentiate between a 7.5% mortality for elderly patients with pathological antecedents and a 25% mortality in patients presenting traumatic brain injury, from a pool of patients with APII values ranging from 10 to 17 and an ISS threshold of 22. The physiological models perform better than the anatomical models in traumatic patients admitted to the ICU. Patients with low scores in the physiological models require an anatomic analysis of the injuries to determine their severity. Copyright © 2017 Elsevier España, S.L.U. y SEMICYUC. All rights reserved.

  15. New reaction rate for 16O( p, γ )17F and its influence on the oxygen isotopic ratios in massive AGB stars

    NARCIS (Netherlands)

    Iliadis, C.; Angulo, C.; Descouvement, P.; Lugaro, M.A.|info:eu-repo/dai/nl/304833975; Mohr, P.


    The 16O(p, γ )17F reaction rate is revisited with special emphasis on the stellar temperature range of T=60-100 MK, important for hot bottom burning in asymptotic giant branch (AGB) stars. We evaluate existing cross-section data that were obtained since 1958 and, if appropriate, correct published

  16. In vitro neuraminidase inhibitory concentration (IC50) of four neuraminidase inhibitors in the Japanese 2016-17 season: Comparison with the 2010-11 to 2015-16 seasons. (United States)

    Ikematsu, Hideyuki; Kawai, Naoki; Iwaki, Norio; Kashiwagi, Seizaburo; Ishikawa, Yusuke; Yamaguchi, Hiroki; Shiosakai, Kazuhito


    To assess the extent of susceptibility to the four most commonly used neuraminidase inhibitors (NAIs) in the viruses epidemic in the 2016-17 Japanese influenza season, we measured the 50% inhibitory concentration (IC 50 ) of these NAIs for influenza virus isolates from patients and compared them with the results from the 2010-11 to 2015-16 seasons. Viral isolation was done with specimens obtained prior to treatment, and the type and subtype was determined by RT-PCR using type- and subtype-specific primers. The IC 50 was determined by a neuraminidase inhibition assay using a fluorescent substrate. A total of 276 virus isolates, 6 A (H1N1)pdm09 (2.2%), 249 A (H3N2) (90.2%), and 21 B (7.6%), had the IC 50 measured for the four NAIs. B isolates included 11 (52.4%), 9 (42.9%), and one (4.8%) of the Victoria, Yamagata, and undetermined strains, respectively. No A (H1N1)pdm09 with highly reduced sensitivity for oseltamivir was found in the 2016-17 season. No isolate with highly reduced sensitivity to the four NAIs have been found for A (H3N2) or B from the 2010-11 to 2016-17 seasons. No significant trend of increase or decrease was found in the geometric mean IC 50 s of the four NAIs during the seven studied seasons. These results indicate that the sensitivity to the four commonly used NAIs has been maintained and that any change in the effectiveness of these NAIs would be minute. Common usage of NAIs for patient treatment has not been a driving force in the selection of NAI resistant viruses. Copyright © 2018 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

  17. Sub-Coulomb α Transfers on C12 and the C12(α, γ)O16 S Factor

    International Nuclear Information System (INIS)

    Brune, C. R.; Geist, W. H.; Kavanagh, R. W.; Veal, K. D.


    The 12 C( α, γ) 16 O reaction is crucial for the understanding of He burning in massive stars, but the low-energy cross section is highly uncertain. To address this problem we have measured at sub-Coulomb energies total cross sections for the 12 C( 6 Li, d) 16 O and 12 C( 7 Li, t) 16 O reactions to the bound 2 + and 1 - states of 16 O . The data are analyzed to obtain the reduced α widths of these states. Together with capture and phase-shift data, these results provide for a more accurate determination of the low-energy 12C(α, γ) 16 O S factor: S E1 (0.3 MeV) =101±17 keV b and S E2 (0.3 MeV) =42 +16 -23 keV b for the E1 and E2 multipole components of the reaction. (c) 1999 The American Physical Society

  18. Role of glia in volume transmission in the CNS

    Czech Academy of Sciences Publication Activity Database

    Syková, Eva


    Roč. 191, č. 658 (2007), s. 16-16 ISSN 1748-1708. [The Physiological Society and The Federation of European Physiological Societies. 11.09.07-14.09.07, Bratislava] R&D Projects: GA MŠk(CZ) LC554 Institutional research plan: CEZ:AV0Z50390512 Keywords : extracellular space Subject RIV: FH - Neurology

  19. Status of physiology education in US Doctor of Pharmacy programs. (United States)

    Islam, Mohammed A; Khan, Seher A; Talukder, Rahmat M


    The purpose of the present study was to assess the current status of physiology education in US Doctor of Pharmacy (PharmD) programs. A survey instrument was developed and distributed through SurveyMonkey to American Association of Colleges of Pharmacy (AACP) Biological Sciences section members of 132 PharmD programs. Survey items focused on soliciting qualitative and quantitative information on the delivery of physiology curricular contents and faculty perceptions of physiology education. A total of 114 programs responded to the survey, resulting in a response rate of 86%. Out of 114 schools/colleges, 61 programs (54%) offered standalone physiology courses, and 53 programs (46%) offered physiology integrated with other courses. When integrated, the average contact hours for physiology contents were significantly reduced compared with standalone courses (30 vs. 84 h, P US PharmD programs remains. The reduction of physiology contents is evident when physiology is taught as a component of integrated courses. Given current trends that favor integrated curricula, these data suggest that additional collaboration among basic and clinical science faculty is required to ensure that physiology contents are balanced and not underemphasized in a PharmD curriculum. Copyright © 2016 the American Physiological Society.

  20. «Zemsky Sobors» of the late 16th – early 17th century in Russia: historiographical stereotypes in the reflection of historical sources

    Directory of Open Access Journals (Sweden)

    Dmitry Vladímirovich LISÉYTSEV


    Full Text Available  In the works on the history of the Russian Zemsky Sobors, there is a tradition to draw a parallel between the Sobors and representative bodies of European countries in the 16th –17th centuries (the English Parliament, the French States General, the Spanish Cortes. It is believed that the end of the 16th – early 17th century, especially the Time of Troubles, was the heyday of Zemsky Sobors (when a weak Central government, in the conditions of the civil war, had to look for support in the organs of estate representation. Meanwhile, the analysis of historical sources does not allow to assume that during this period the Zemsky Sobors played a greater role than they did previously. Even the most studied Zemsky Sobors – the elective Sobors of 1598 and 1613 – were held with serious violations of election procedures, and the provinces were not represented to the extent it was described in the official documents. The question of the place of the Zemsky Sobors in the political system of Muscovite state at the beginning of the 17th century requires further analysis.

  1. Analysis of 16 autosomal STRs and 17 Y-STRs in an indigenous Maya population from Guatemala. (United States)

    Cardoso, Sergio; Sevillano, Rubén; Illescas, María J; de Pancorbo, Marian Martínez


    The aim of this study was to contribute new data on autosomal STR and Y-STR markers of the Mayas from Guatemala in order to improve available databases of forensic interest. We analyzed 16 autosomal STR markers in a population sample of 155 indigenous Maya and 17 Y-chromosomal STR markers in the 100 males of the sample. Deviations from Hardy-Weinberg equilibrium and linkage disequilibrium between autosomal STR markers were not observed at any loci. The combined power of exclusion was estimated as 99.9991% and the combined power of discrimination was >99.999999999999%. Haplotype diversity of Y-STRs was calculated as 0.9984 ± 0.0018 and analysis of pairwise genetic distances (Rst) supported the Native American background of the population.

  2. Treatment guidelines for Circadian Rhythm Sleep-Wake Disorders of the Polish Sleep Research Society and the Section of Biological Psychiatry of the Polish Psychiatric Association. Part I. Physiology, assessment and therapeutic methods. (United States)

    Wichniak, Adam; Jankowski, Konrad S; Skalski, Michal; Skwarło-Sońta, Krystyna; Zawilska, Jolanta B; Żarowski, Marcin; Poradowska, Ewa; Jernajczyk, Wojciech


    Majority of the physiological processes in the human organism are rhythmic. The most common are the diurnal changes that repeat roughly every 24 hours, called circadian rhythms. Circadian rhythms disorders have negative influence on human functioning. The aim of this article is to present the current understanding of the circadian rhythms physiological role, with particular emphasis on the circadian rhythm sleep-wake disorders (CRSWD), principles of their diagnosis and chronobiological therapy. The guidelines are based on the review of recommendations from the scientific societies involved in sleep medicine and the clinical experiences of the authors. Researchers participating in the preparation of guidelines were invited by the Polish Sleep Research Society and the Section of Biological Psychiatry of the Polish Psychiatric Association, based on their significant contributions in circadian rhythm research and/or clinical experience in the treatment of such disorders. Finally, the guidelines were adjusted to the questions and comments given by the members of both Societies. CRSWD have a significant negative impact on human health and functioning. Standard methods used to assess CRSWD are sleep diaries and sleep logs, while the actigraphy, when available, should be also used. The most effective methods of CRSWD treatment are melatonin administration and light therapy. Behavioral interventions are also recommended. Afourteen-day period of sleep-wake rhythm assessment in CRSWD enables accurate diagnosis, adequate selection of chronobiological interventions, and planning adequate diurnal timing of their application. This type of assessment is quite easy, low-cost, and provides valuable indications how to adjust the therapeutic approach to the circadian phase of the particular patient.

  3. Electron scattering from 17O

    International Nuclear Information System (INIS)

    Kim, J.C.; Hicks, R.S.; Yen, R.; Auer, I.P.; Caplan, H.S.; Bergstrom, J.C.


    Cross sections for elastic and inelastic scattering of electrons from 17 O have been measured for momentum transfers up to 1.2 fm -1 . The elastic cross section indicates that the rms charge radii of 17 O and 16 O are equal to within a few parts in a thousand: 2 17 >sup(1/2)/ 2 16 >sub(1/2)=1.0015+-0.0025. Reduced transition probabilities and ground-state radiative widths are deduced for 17 O excited states below 9 MeV. Various aspects of the inelastic spectrum are discussed, with emphasis on the 'single-particle' levels at 0.871 (1/2 + ) and 5.083 (3/2 + ) MeV, the levels at 7.569 (7/2 - ) and 7.378 (5/2 + ) MeV, and the spectrum of electric octupole excitations. (Auth.)

  4. Mpv17 in mitochondria protects podocytes against mitochondrial dysfunction and apoptosis in vivo and in vitro. (United States)

    Casalena, Gabriela; Krick, Stefanie; Daehn, Ilse; Yu, Liping; Ju, Wenjun; Shi, Shaolin; Tsai, Su-yi; D'Agati, Vivette; Lindenmeyer, Maja; Cohen, Clemens D; Schlondorff, Detlef; Bottinger, Erwin P


    Mitochondrial dysfunction is increasingly recognized as contributing to glomerular diseases, including those secondary to mitochondrial DNA (mtDNA) mutations and deletions. Mitochondria maintain cellular redox and energy homeostasis and are a major source of intracellular reactive oxygen species (ROS) production. Mitochondrial ROS accumulation may contribute to stress-induced mitochondrial dysfunction and apoptosis and thereby to glomerulosclerosis. In mice, deletion of the gene encoding Mpv17 is associated with glomerulosclerosis, but the underlying mechanism remains poorly defined. Here we report that Mpv17 localizes to mitochondria of podocytes and its expression is reduced in several glomerular injury models and in human focal segmental glomerulosclerosis (FSGS) but not in minimal change disease. Using models of mild or severe nephrotoxic serum nephritis (NTSN) in Mpv17(+/+) wild-type (WT) and Mpv17(-/-) knockout mice, we found that Mpv17 deficiency resulted in increased proteinuria (mild NTSN) and renal insufficiency (severe NTSN) compared with WT. These lesions were associated with increased mitochondrial ROS generation and mitochondrial injury such as oxidative DNA damage. In vitro, podocytes with loss of Mpv17 function were characterized by increased susceptibility to apoptosis and ROS injury including decreased mitochondrial function, loss of mtDNA content, and change in mitochondrial configuration. In summary, the inner mitochondrial membrane protein Mpv17 in podocytes is essential for the maintenance of mitochondrial homeostasis and protects podocytes against oxidative stress-induced injury both in vitro and in vivo. Copyright © 2014 the American Physiological Society.

  5. Physiological and Selective Attention Demands during an International Rally Motor Sport Event

    Directory of Open Access Journals (Sweden)

    Anthony P. Turner


    Full Text Available Purpose. To monitor physiological and attention responses of drivers and codrivers during a World Rally Championship (WRC event. Methods. Observational data were collected from ten male drivers/codrivers on heart rate (HR, core body (Tcore and skin temperature (Tsk, hydration status (urine osmolality, fluid intake (self-report, and visual and auditory selective attention (performance tests. Measures were taken pre-, mid-, and postcompetition day and also during the precompetition reconnaissance. Results. In ambient temperatures of 20.1°C (in-car peak 33.9°C mean (SD peak HR and Tcore were significantly elevated (P<0.05 during rally compared to reconnaissance (166 (17 versus 111 (16 beats·min−1 and 38.5 (0.4 versus 37.6 (0.2°C, resp.. Values during competitive stages were substantially higher in drivers. High urine osmolality was indicated in some drivers within competition. Attention was maintained during the event but was significantly lower prerally, though with considerable individual variation. Conclusions. Environmental and physical demands during rally competition produced significant physiological responses. Challenges to thermoregulation, hydration status, and cognitive function need to be addressed to minimise potentially negative effects on performance and safety.

  6. Endogenous target mimics down-regulate miR160 mediation of ARF10, -16 and -17 cleavage during somatic embryogenesis in Dimocarpus longan Lour.

    Directory of Open Access Journals (Sweden)

    yuling elin


    Full Text Available MicroRNA160 plays a critical role in plant development by negatively regulating the auxin response factors ARF10, -16 and -17. However, the ways in which miR160 expression is regulated at the transcriptional level, and how miR160 interacts with its targets during plant embryo development, remain unknown. Here, we studied the regulatory relationships among endogenous target mimics (eTMs, and miR160 and its targets, and their involvement in hormone signaling and somatic embryogenesis (SE in Dimocarpus longan. We identified miR160 family members and isolated the miR160 precursor, primary transcript, and promoter. The promoter contained cis-acting elements responsive to stimuli such as light, abscisic acid, salicylic acid and heat stress. The pri-miR160 was down-regulated in response to salicylic acid but up-regulated by gibberellic acid, ethylene, and methyl jasmonate treatment, suggesting that pri-miR160 was associated with hormone transduction. Dlo-miR160a, -a* and -d* reached expression peaks in torpedo-shaped embryos, globular embryos and cotyledonary embryos, respectively, but were barely detectable in embryogenic callus. This suggests that they have expression-related and functional diversity, especially during the middle and later developmental stages of SE. Four potential eTMs for miR160 were identified. Two of them, glucan endo-1,3-beta- glucosidase-like protein 2-like and calpain-type cysteine protease DEK1, were confirmed to control the corresponding dlo-miR160a* expression level. This suggests that they may function to abolish the binding between dlo-miR160a* and its targets. These two eTMs also participated in auxin and ABA signal transduction. DlARF10, -16, and -17 targeting by dlo-miR160a was confirmed; their expression levels were higher in friable-embryogenic callus and incomplete compact pro-embryogenic cultures and responded to 2,4-D, suggesting they may play a major role in the early stages of longan SE dependent on 2,4-D. The e

  7. In vivo estimation of transverse relaxation time constant (T2 ) of 17 human brain metabolites at 3T. (United States)

    Wyss, Patrik O; Bianchini, Claudio; Scheidegger, Milan; Giapitzakis, Ioannis A; Hock, Andreas; Fuchs, Alexander; Henning, Anke


    The transverse relaxation times T 2 of 17 metabolites in vivo at 3T is reported and region specific differences are addressed. An echo-time series protocol was applied to one, two, or three volumes of interest with different fraction of white and gray matter including a total number of 106 healthy volunteers and acquiring a total number of 128 spectra. The data were fitted with the 2D fitting tool ProFit2, which included individual line shape modeling for all metabolites and allowed the T 2 calculation of 28 moieties of 17 metabolites. The T 2 of 10 metabolites and their moieties have been reported for the first time. Region specific T 2 differences in white and gray matter enriched tissue occur in 16 of 17 metabolites examined including single resonance lines and coupled spin systems. The relaxation time T 2 is regions specific and has to be considered when applying tissue composition correction for internal water referencing. Magn Reson Med 80:452-461, 2018. © 2018 International Society for Magnetic Resonance in Medicine. © 2018 International Society for Magnetic Resonance in Medicine.

  8. Validating Westinghouse atom 16 x 16 and 18 x 18 PWR fuel performance

    International Nuclear Information System (INIS)

    Andersson, S.; Gustafson, J.; Jourdain, P.; Lindstroem, L.; Hallstadius, L.; Hofling, C.G.


    Westinghouse Atom designs and fabricates PWR fuel for all major European fuel types: 17 x 17 standard (12 ft) and 17 x 17 XL (14 ft) for Westinghouse type PWRs, and 16 x 16 and 18 x 18 fuel for Siemens type PWRs. The W Atom PWR fuel designs are based on the extensive Westinghouse CE PWR fuel experience from combustion engineering type PWRs. The W atom designs utilise basic design features from the W CE fuel tradition, such as all-Zircaloy mid grids and the proven ( 6 rod years) Guardian TM debris catcher, which is integrated in the bottom Inconel grid. Several new features have been developed to meet with stringent European requirements originating from requirements on very high burnup, in combination with low-leakage core operating strategies and high coolant temperatures. The overall reliability of the Westinghouse Atom PWR fuel is very high; no fuel failure has been detected since 1997. (orig.)

  9. Bulletin of the Chemical Society of Ethiopia - Vol 16, No 2 (2002)

    African Journals Online (AJOL)

    Bulletin of the Chemical Society of Ethiopia. ... Picranitine, a new indole alkaloid from picralima nitida (APOCYNACEAE) · EMAIL FREE FULL TEXT ... Reaction of propargyltrimethylsilane magnesium bromide with aldimines: synthesis of ...

  10. DAF-16 and TCER-1 Facilitate Adaptation to Germline Loss by Restoring Lipid Homeostasis and Repressing Reproductive Physiology in C. elegans (United States)

    Amrit, Francis Raj Gandhi; Steenkiste, Elizabeth Marie; Ratnappan, Ramesh; Chen, Shaw-Wen; McClendon, T. Brooke; Kostka, Dennis; Yanowitz, Judith; Olsen, Carissa Perez; Ghazi, Arjumand


    Elimination of the proliferating germline extends lifespan in C. elegans. This phenomenon provides a unique platform to understand how complex metazoans retain metabolic homeostasis when challenged with major physiological perturbations. Here, we demonstrate that two conserved transcription regulators essential for the longevity of germline-less adults, DAF-16/FOXO3A and TCER-1/TCERG1, concurrently enhance the expression of multiple genes involved in lipid synthesis and breakdown, and that both gene classes promote longevity. Lipidomic analyses revealed that key lipogenic processes, including de novo fatty acid synthesis, triglyceride production, desaturation and elongation, are augmented upon germline removal. Our data suggest that lipid anabolic and catabolic pathways are coordinately augmented in response to germline loss, and this metabolic shift helps preserve lipid homeostasis. DAF-16 and TCER-1 also perform essential inhibitory functions in germline-ablated animals. TCER-1 inhibits the somatic gene-expression program that facilitates reproduction and represses anti-longevity genes, whereas DAF-16 impedes ribosome biogenesis. Additionally, we discovered that TCER-1 is critical for optimal fertility in normal adults, suggesting that the protein acts as a switch supporting reproductive fitness or longevity depending on the presence or absence of the germline. Collectively, our data offer insights into how organisms adapt to changes in reproductive status, by utilizing the activating and repressive functions of transcription factors and coordinating fat production and degradation. PMID:26862916

  11. Hydrogenation of the Exocyclic Olefinic Bond at C-16/C-17 Position of ent-Kaurane Diterpene Glycosides of Stevia rebaudiana Using Various Catalysts (United States)

    Chaturvedula, Venkata Sai Prakash; Prakash, Indra


    Catalytic hydrogenation of the exocyclic double bond present between C16 and C17 carbons of the four ent-kaurane diterpene glycosides namely rebaudioside A, rebaudioside B, rebaudioside C, and rebaudioside D isolated from Stevia rebaudiana has been carried out using Pt/C, Pd(OH)2, Rh/C, Raney Ni, PtO2, and 5% Pd/BaCO3 to their corresponding dihydro derivatives with 17α and 17β methyl group isomers. Reactions were performed using the above-mentioned catalysts with the solvents methanol, water, and ethanol/water (8:2) under various conditions. Synthesis of reduced steviol glycosides was performed using straightforward chemistry and their structures were characterized on the basis of 1D and 2D NMR spectral data, including a comparison with reported spectral data. PMID:23896597

  12. Hydrogenation of the Exocyclic Olefinic Bond at C-16/C-17 Position of ent-Kaurane Diterpene Glycosides of Stevia rebaudiana Using Various Catalysts

    Directory of Open Access Journals (Sweden)

    Indra Prakash


    Full Text Available Catalytic hydrogenation of the exocyclic double bond present between C16 and C17 carbons of the four ent-kaurane diterpene glycosides namely rebaudioside A, rebaudioside B, rebaudioside C, and rebaudioside D isolated from Stevia rebaudiana has been carried out using Pt/C, Pd(OH2, Rh/C, Raney Ni, PtO2, and 5% Pd/BaCO3 to their corresponding dihydro derivatives with 17α and 17β methyl group isomers. Reactions were performed using the above-mentioned catalysts with the solvents methanol, water, and ethanol/water (8:2 under various conditions. Synthesis of reduced steviol glycosides was performed using straightforward chemistry and their structures were characterized on the basis of 1D and 2D NMR spectral data, including a comparison with reported spectral data.

  13. Francesco Sansovino’s anthology of novella and its reception in 16th- and 17th- century Spain

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    Diana Berruezo Sánchez


    Full Text Available This article delves into Francesco Sansovino’s successful anthology of novelle and its complex circulation and reception in Spain. Firstly, it outlines the anthology’s corrections, insertions, and deletions from its publication in 1561 to its latest edition in 1610. Secondly, it explains the misinterpretation from which the anthologist is deemed as the author of the short stories. As argued here, the fact that the letter addressed to the readers was not included in the latest editions triggered the misunderstanding about the authorship of the short stories. Finally, it offers significant data that proves the circulation of the anthology in Spain in the 16th and 17th Centuries.

  14. Preparation of 16β-Estradiol Derivative Libraries as Bisubstrate Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 Using the Multidetachable Sulfamate Linker

    Directory of Open Access Journals (Sweden)

    Donald Poirier


    Full Text Available Combinatorial chemistry is a powerful tool used to rapidly generate a large number of potentially biologically active compounds. In our goal to develop bisubstrate inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1 that interact with both the substrate (estrone or estradiol and the cofactor (NAD(PH binding sites, we used parallel solid-phase synthesis to prepare three libraries of 16β-estradiol derivatives with two or three levels of molecular diversity. From estrone, we first synthesized a sulfamate precursor that we loaded on trityl chloride resin using the efficient multidetachable sulfamate linker strategy recently developed in our laboratory. We then introduced molecular diversity [one or two amino acid(s followed by a carboxylic acid] on steroid nucleus by Fmoc peptide chemistry. Finally, after a nucleophilic cleavage, libraries of 30, 63 and 25 estradiol derivatives were provided. A library of 30 sulfamoylated estradiol derivatives was also generated by acidic cleavage and its members were screened for inhibition of steroid sulfatase. Biological evaluation on homogenated HEK-293 cells overexpressing 17β-HSD1 of the estradiol derivatives carrying different oligoamide-type chains at C-16 first revealed that three levels of molecular diversity (a spacer of two amino acids were necessary to interact with the adenosine part of the cofactor binding site. Second, the best inhibition was obtained when hydrophobic residues (phenylalanine were used as building blocks.


    Directory of Open Access Journals (Sweden)

    Nikita Leonidovich Karavaev


    Full Text Available In article, the author envisages the anthropological problems of the modern information society. There is a new definition of information society, the main factor of which is the automatization of information processes. Different types of information technology impacts (informational and technological impacts on human being are considered. In addition, the author shows the primary transformation of human being due to modern information technologies, based on computer and telecommunication technique.DOI:

  16. The kin17 Protein in Murine Melanoma Cells

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    Anelise C. Ramos


    Full Text Available kin17 has been described as a protein involved in the processes of DNA replication initiation, DNA recombination, and DNA repair. kin17 has been studied as a potential molecular marker of breast cancer. This work reports the detection and localization of this protein in the murine melanoma cell line B16F10-Nex2 and in two derived subclones with different metastatic potential, B16-8HR and B16-10CR. Nuclear and chromatin-associated protein fractions were analyzed, and kin17 was detected in all fractions, with an elevated concentration observed in the chromatin-associated fraction of the clone with low metastatic potential, suggesting that the kin17 expression level could be a marker of melanoma.

  17. A history of the American Society for Clinical Investigation (United States)

    Howell, Joel D.


    One hundred years ago, in 1909, the American Society for Clinical Investigation (ASCI) held its first annual meeting. The founding members based this new society on a revolutionary approach to research that emphasized newer physiological methods. In 1924 the ASCI started a new journal, the Journal of Clinical Investigation. The ASCI has also held an annual meeting almost every year. The society has long debated who could be a member, with discussions about whether members must be physicians, what sorts of research they could do, and the role of women within the society. The ASCI has also grappled with what else the society should do, especially whether it ought to take a stand on policy issues. ASCI history has reflected changing social, political, and economic contexts, including several wars, concerns about the ethics of biomedical research, massive increases in federal research funding, and an increasingly large and specialized medical environment. PMID:19348041

  18. Promoting Employee Health Through an American Cancer Society Program, The CEOs Challenge, Washington State, 2013-2015. (United States)

    Harris, Jeffrey R; Parrish, Amanda T; Kohn, Marlana; Hammerback, Kristen; McMillan, Becca; Hannon, Peggy A


    Evidence-based practices in the workplace can increase levels of healthy eating, cancer screening, physical activity, and tobacco cessation but are underused, even in large workplaces. This report summarizes an evaluation of the first year of The CEOs Challenge, a program developed by the American Cancer Society to promote implementation and maintenance of health-promoting, evidence-based workplace practices by large companies. Use of 17 evidence-based practices by 17 companies in the Washington State Chapter of the American Cancer Society's CEOs Against Cancer network was assessed via survey and scored from 0 to 100. Companies received a written report of their baseline performance, followed by at least quarterly consultations with American Cancer Society staff members trained to assist in implementation of these practices. Follow-up performance was measured at 1 year. At baseline, implementation scores were 54.8 for cancer screening, 46.5 for healthy eating, 59.8 for physical activity, and 68.2 for tobacco cessation. At follow-up, scores increased by 19.6 for cancer screening, 19.4 for healthy eating, 16.0 for physical activity, and 9.4 points for tobacco cessation. The CEOs Challenge is a promising approach to chronic disease prevention via the workplace. It brings together one of the nation's largest health-promoting voluntary agencies with the nation's largest employers to promote evidence-based practices targeted at the most common causes of disease and death. The program increased the adoption of these practices and was well-accepted.

  19. A molecular concept of caste in insect societies. (United States)

    Sumner, Seirian; Bell, Emily; Taylor, Daisy


    The term 'caste' is used to describe the division of reproductive labour that defines eusocial insect societies. The definition of 'caste' has been debated over the last 50 years, specifically with respect to the simplest insect societies; this raises the question of whether a simple categorisation of social behaviour by reproductive state alone is helpful. Gene-level analyses of behaviours of individuals in hymenopteran social insect societies now provide a new empirical base-line for defining caste and understanding the evolution and maintenance of a reproductive division of labour. We review this literature to identify a set of potential molecular signatures that, combined with behavioural, morphological and physiological data, help define caste more precisely; these signatures vary with the type of society, and are likely to be influenced by ecology, life-history, and stage in the colony cycle. We conclude that genomic approaches provide us with additional ways to help quantify and categorise caste, and behaviour in general. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. Developmental validation of the PowerPlex(®) ESI 16 and PowerPlex(®) ESI 17 Systems: STR multiplexes for the new European standard. (United States)

    Tucker, Valerie C; Hopwood, Andrew J; Sprecher, Cynthia J; McLaren, Robert S; Rabbach, Dawn R; Ensenberger, Martin G; Thompson, Jonelle M; Storts, Douglas R


    In response to the ENFSI and EDNAP groups' call for new STR multiplexes for Europe, Promega(®) developed a suite of four new DNA profiling kits. This paper describes the developmental validation study performed on the PowerPlex(®) ESI 16 (European Standard Investigator 16) and the PowerPlex(®) ESI 17 Systems. The PowerPlex(®) ESI 16 System combines the 11 loci compatible with the UK National DNA Database(®), contained within the AmpFlSTR(®) SGM Plus(®) PCR Amplification Kit, with five additional loci: D2S441, D10S1248, D22S1045, D1S1656 and D12S391. The multiplex was designed to reduce the amplicon size of the loci found in the AmpFlSTR(®) SGM Plus(®) kit. This design facilitates increased robustness and amplification success for the loci used in the national DNA databases created in many countries, when analyzing degraded DNA samples. The PowerPlex(®) ESI 17 System amplifies the same loci as the PowerPlex(®) ESI 16 System, but with the addition of a primer pair for the SE33 locus. Tests were designed to address the developmental validation guidelines issued by the Scientific Working Group on DNA Analysis Methods (SWGDAM), and those of the DNA Advisory Board (DAB). Samples processed include DNA mixtures, PCR reactions spiked with inhibitors, a sensitivity series, and 306 United Kingdom donor samples to determine concordance with data generated with the AmpFlSTR(®) SGM Plus(®) kit. Allele frequencies from 242 white Caucasian samples collected in the United Kingdom are also presented. The PowerPlex(®) ESI 16 and ESI 17 Systems are robust and sensitive tools, suitable for the analysis of forensic DNA samples. Full profiles were routinely observed with 62.5pg of a fully heterozygous single source DNA template. This high level of sensitivity was found to impact on mixture analyses, where 54-86% of unique minor contributor alleles were routinely observed in a 1:19 mixture ratio. Improved sensitivity combined with the robustness afforded by smaller amplicons

  1. Baseline Physiologic and Psychosocial Characteristics of Transgender Youth Seeking Care for Gender Dysphoria. (United States)

    Olson, Johanna; Schrager, Sheree M; Belzer, Marvin; Simons, Lisa K; Clark, Leslie F


    The purpose of this study was to describe baseline characteristics of participants in a prospective observational study of transgender youth (aged 12-24 years) seeking care for gender dysphoria at a large, urban transgender youth clinic. Eligible participants presented consecutively for care at between February 2011 and June 2013 and completed a computer-assisted survey at their initial study visit. Physiologic data were abstracted from medical charts. Data were analyzed by descriptive statistics, with limited comparisons between transmasculine and transfeminine participants. A total of 101 youth were evaluated for physiologic parameters, 96 completed surveys assessing psychosocial parameters. About half (50.5%) of the youth were assigned a male sex at birth. Baseline physiologic values were within normal ranges for assigned sex at birth. Youth recognized gender incongruence at a mean age of 8.3 years (standard deviation = 4.5), yet disclosed to their family much later (mean = 17.1; standard deviation = 4.2). Gender dysphoria was high among all participants. Thirty-five percent of the participants reported depression symptoms in the clinical range. More than half of the youth reported having thought about suicide at least once in their lifetime, and nearly a third had made at least one attempt. Baseline physiologic parameters were within normal ranges for assigned sex at birth. Transgender youth are aware of the incongruence between their internal gender identity and their assigned sex at early ages. Prevalence of depression and suicidality demonstrates that youth may benefit from timely and appropriate intervention. Evaluation of these youth over time will help determine the impact of medical intervention and mental health therapy. Copyright © 2015 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

  2. Evaluation of the 17 June 1997 Criticality Accident at Arzamas-16

    International Nuclear Information System (INIS)

    Morris Klein


    On June 17, 1997, a critically accident occurred at Arzamas-16, which resulted in the death (within three days) of A. N. Zakharov, a Russian scientist with 20 years' experience conducting multiassembly experiments. In this case, the multiplying assembly was a fast metal system consisting of a 235 U (90% enriched) core and a copper reflector. According to the Russian press, ''Zakharov misjudged the degree of criticality of the breeding system and committed several gross violations of regulations.'' As we see it, there were three major causes of this accident. First, the experiment was flawed by Zakharov's misreading of the appropriate size of the assembly, which he took from a notebook that described the old experiment he was attempting to repeat. Second, he disregarded the appropriate procedures and safety regulations. Third, these two mistakes were compounded by an improperly set audible alarm system and Zakharov's unsafe use of the table. We also discuss our reconstruction of the accident based on information given by the Russians to US scientists and information culled from Russian newspaper and magazine articles. We also describe our thoughts on the behavior of the assembly following the accident and the radiation dose level Zakharov may have received. These levels match values we have lately obtained from translations of Russian news articles. This accident clearly points out the penalty for weak administrative control of work with multiplying systems. Criticality experimentation requires formality of operation. The experimenter, his peers, and a trained safety person need to document that they understand the experiment and how it will be conducted. Knowing that the experiment was successfully run several decades ago does not justify bypassing a safety evaluation

  3. Exploitation of physiological and genetic variability to enhance crop productivity

    International Nuclear Information System (INIS)

    Harper, J.E.; Schrader, L.E.; Howell, R.W.


    The American Society of Plant Physiologists recognizes the need to identify primary physiological limitations to crop productivity. This basic information is essential to facilitate and accelerate progress towards the goal of enhanced productivity on a global scale. Plant breeders currently select for desirable physiological traits intuitively by selecting for enhanced yield capability. Identification of specific physiological limitations by plant physiologists could potentially foster interdisciplinary research and accelerate progress in breeding for improved cultivars. The recent upsurge in research interest and funding in the area of biotechnology further exemplifies the importance of identification of specific physiological traits which may be amenable to manipulation at the molecular as well as the whole plant level. The theme of this symposium was to focus attention on current progress in identification of possible physiological limitations. The purpose of this publication is to document that progress and hopefully to extend the stimulating ideas to those who were unable to attend the symposium

  4. Performance in physiology evaluation: possible improvement by active learning strategies. (United States)

    Montrezor, Luís H


    The evaluation process is complex and extremely important in the teaching/learning process. Evaluations are constantly employed in the classroom to assist students in the learning process and to help teachers improve the teaching process. The use of active methodologies encourages students to participate in the learning process, encourages interaction with their peers, and stimulates thinking about physiological mechanisms. This study examined the performance of medical students on physiology over four semesters with and without active engagement methodologies. Four activities were used: a puzzle, a board game, a debate, and a video. The results show that engaging in activities with active methodologies before a physiology cognitive monitoring test significantly improved student performance compared with not performing the activities. We integrate the use of these methodologies with classic lectures, and this integration appears to improve the teaching/learning process in the discipline of physiology and improves the integration of physiology with cardiology and neurology. In addition, students enjoy the activities and perform better on their evaluations when they use them. Copyright © 2016 The American Physiological Society.

  5. Recognizing spontaneous facial expressions of emotion in a small-scale society of Papua New Guinea. (United States)

    Crivelli, Carlos; Russell, James A; Jarillo, Sergio; Fernández-Dols, José-Miguel


    We report 2 studies on how residents of Papua New Guinea interpret facial expressions produced spontaneously by other residents of Papua New Guinea. Members of a small-scale indigenous society, Trobrianders (Milne Bay Province; N = 32, 14 to 17 years) were shown 5 facial expressions spontaneously produced by members of another small-scale indigenous society, Fore (Eastern Highlands Province) that Ekman had photographed, labeled, and published in The Face of Man (1980), each as an expression of a basic emotion: happiness, sadness, anger, surprise, and disgust. Trobrianders were asked to use any word they wanted to describe how each person shown felt and to provide valence and arousal ratings. Other Trobrianders (N = 24, 12 to 14 years) were shown the same photographs but asked to choose their response from a short list. In both studies, agreement with Ekman's predicted labels was low: 0% to 16% and 13% to 38% of observers, respectively. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  6. Determination of S17(0) from transfer reactions

    International Nuclear Information System (INIS)

    Tribble, R.E.; Azhari, A.; Clark, H.L.; Gagliardi, C.A.; Lui, Y.; Mukhamedzhanov, A.M.; Sattarov, A.; Trache, L.; Burjan, V.; Cejpek, J.; Kroha, V.; Piskor, S.; Vincour, J.


    The S-factor for the direct capture reaction 7 Be(p,γ) 8 B can be found at astrophysical energies from the asymptotic normalization coefficients which provide the normalization of the tails of the overlap functions for 8 B→ 7 Be+p. Peripheral transfer reactions offer a technique to determine these asymptotic normalization coefficients. As a test of the technique, the 16 O( 3 He,d) 17 F reaction has been used to determine asymptotic normalization coefficients for transitions to the ground and first excited states of 17 F. The S-factors for 16 O(p,γ) 17 F calculated from these 17 F→ 16 O+p asymptotic normalization coefficients are found to be in very good agreement with recent measurements. Following the same technique, the 10 B( 7 Be, 8 B) 9 Be reaction has been used to measure the asymptotic normalization coefficient for 7 Be(p,γ) 8 B. This result provides an indirect determination of S 17 (0). copyright 1998 American Institute of Physics

  7. Fostering improved anatomy and physiology instructor pedagogy. (United States)

    Mattheis, Allison; Jensen, Murray


    Despite widespread calls for reform in undergraduate science, technology, engineering, and mathematics education, effecting lasting change in instructor practice is challenging to achieve. This article describes the results of a 2-yr research study that involved efforts to develop the pedagogical expertise of a group of anatomy and physiology instructors at the college level. Data were collected through a series of individual interviews that included the use of the Teacher Beliefs Inventory questionnaire (23) along with observations onsite in participants' college classrooms and at process-oriented guided inquiry learning (POGIL) curriculum writing workshops. Findings indicated attitudinal shifts on the part of participants from teacher-centered to more student-centered pedagogy and supported the benefits of long-term professional development for instructors. Here, we documented the successful progress of these professors as they participated in a curriculum development process that emphasized student-centered teaching with the goal of promoting broader change efforts in introductory anatomy and physiology. Copyright © 2014 The American Physiological Society.

  8. Dehydration: physiology, assessment, and performance effects. (United States)

    Cheuvront, Samuel N; Kenefick, Robert W


    This article provides a comprehensive review of dehydration assessment and presents a unique evaluation of the dehydration and performance literature. The importance of osmolality and volume are emphasized when discussing the physiology, assessment, and performance effects of dehydration. The underappreciated physiologic distinction between a loss of hypo-osmotic body water (intracellular dehydration) and an iso-osmotic loss of body water (extracellular dehydration) is presented and argued as the single most essential aspect of dehydration assessment. The importance of diagnostic and biological variation analyses to dehydration assessment methods is reviewed and their use in gauging the true potential of any dehydration assessment method highlighted. The necessity for establishing proper baselines is discussed, as is the magnitude of dehydration required to elicit reliable and detectable osmotic or volume-mediated compensatory physiologic responses. The discussion of physiologic responses further helps inform and explain our analysis of the literature suggesting a ≥ 2% dehydration threshold for impaired endurance exercise performance mediated by volume loss. In contrast, no clear threshold or plausible mechanism(s) support the marginal, but potentially important, impairment in strength, and power observed with dehydration. Similarly, the potential for dehydration to impair cognition appears small and related primarily to distraction or discomfort. The impact of dehydration on any particular sport skill or task is therefore likely dependent upon the makeup of the task itself (e.g., endurance, strength, cognitive, and motor skill). © 2014 American Physiological Society.

  9. IL-17 for therapy. (United States)

    Kurschus, Florian C; Moos, Sonja


    The cytokine IL-17 is now a target for an array of therapeutic monoclonal antibodies supposed to treat a variety of inflammatory diseases. The forerunner Secukinumab, an IL-17A neutralizing antibody, is meanwhile approved as first-line treatments for moderate-to-severe plaque psoriasis, and as second-line treatment for psoriatic arthritis and ankylosing spondylitis. Ixekizumab and Brodalumab, both also targeting the IL-17 pathway, were also recently approved by the FDA for plaque psoriasis. Using mice overexpressing IL-17A in a tissue of choice, we showed that the ectopic expression of this cytokine in keratinocytes resulted in a spontaneous and very strong form of psoriasis-like dermatitis. Interestingly, this model showed some typical comorbidities found in humans with psoriasis. In this review, we will discuss why IL-17 is a good target especially in psoriasis and what we learned from mouse models about its functions in pathological situations. Copyright © 2017 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.

  10. Love-hate for man-machine metaphors in Soviet physiology: from Pavlov to "physiological cybernetics". (United States)

    Gerovitch, Slava


    This article reinterprets the debate between orthodox followers of the Pavlovian reflex theory and Soviet "cybernetic physiologists" in the 1950s and 60s as a clash of opposing man-machine metaphors. While both sides accused each other of "mechanistic," reductionist methodology, they did not see anything "mechanistic" about their own central metaphors: the telephone switchboard metaphor for nervous activity (the Pavlovians), and the analogies between the human brain and a computer (the cyberneticians). I argue that the scientific utility of machine analogies was closely intertwined with their philosophical and political meanings and that new interpretations of these metaphors emerged as a result of political conflicts and a realignment of forces within the scientific community and in society at large. I suggest that the constant travel of man-machine analogies, back and forth between physiology and technology has blurred the traditional categories of the "mechanistic" and the "organic" in Soviet neurophysiology, as perhaps in the history of physiology in general.

  11. Physiology knowledge plays a role when novices learn technical echocardiography skills

    DEFF Research Database (Denmark)

    Nielsen, Dorte Guldbrand; Gøtzsche, Ole; Eika, Berit


    Purpose: Little is known about factors of relevance for achieving technical skills of echocardiography (TTE); one of the essential skills defined by the European Society of Cardiology Core Curriculum. In an earlier study we have shown that there is a strong correlation between physiology knowledge...... and interpretation skills of intermediately trained echocardiographers. This study investigates the role of physiology knowledge in the development of echocardiographic technical expertise. Methods: Forty-five physicians (15 novices, 15 intermediates and 15 experts) were evaluated on technical skills. Participants...... of echocardiography relevant physiology knowledge. Results: A strong and significant correlation between expertise level and technical checklist scores was found (r = .76, p

  12. A computational model of the hypothalamic - pituitary - gonadal axis in female fathead minnows (Pimephales promelas exposed to 17α-ethynylestradiol and 17β-trenbolone

    Directory of Open Access Journals (Sweden)

    Lazorchak James M


    Full Text Available Abstract Background Endocrine disrupting chemicals (e.g., estrogens, androgens and their mimics are known to affect reproduction in fish. 17α-ethynylestradiol is a synthetic estrogen used in birth control pills. 17β-trenbolone is a relatively stable metabolite of trenbolone acetate, a synthetic androgen used as a growth promoter in livestock. Both 17α-ethynylestradiol and 17β-trenbolone have been found in the aquatic environment and affect fish reproduction. In this study, we developed a physiologically-based computational model for female fathead minnows (FHM, Pimephales promelas, a small fish species used in ecotoxicology, to simulate how estrogens (i.e., 17α-ethynylestradiol or androgens (i.e., 17β-trenbolone affect reproductive endpoints such as plasma concentrations of steroid hormones (e.g., 17β-estradiol and testosterone and vitellogenin (a precursor to egg yolk proteins. Results Using Markov Chain Monte Carlo simulations, the model was calibrated with data from unexposed, 17α-ethynylestradiol-exposed, and 17β-trenbolone-exposed FHMs. Four Markov chains were simulated, and the chains for each calibrated model parameter (26 in total converged within 20,000 iterations. With the converged parameter values, we evaluated the model's predictive ability by simulating a variety of independent experimental data. The model predictions agreed with the experimental data well. Conclusions The physiologically-based computational model represents the hypothalamic-pituitary-gonadal axis in adult female FHM robustly. The model is useful to estimate how estrogens (e.g., 17α-ethynylestradiol or androgens (e.g., 17β-trenbolone affect plasma concentrations of 17β-estradiol, testosterone and vitellogenin, which are important determinants of fecundity in fish.

  13. Fall risk in Chinese community-dwelling older adults: A physiological profile assessment study. (United States)

    Siong, Kar-Ho; Kwan, Marcella Mun-San; Lord, Stephen R; Lam, Andrew Kwok-Cheung; Tsang, William Wai-Nam; Cheong, Allen Ming-Yan


    The short-form Physiological Profile Assessment (PPA) is increasingly used in clinical practice for assessing fall risk in older people. However, a normative database is only available for Caucasian populations. The purpose of the present study was to develop a normative database for Hong Kong Chinese older people and examine the fall risk profile of this population. A total of 622 participants aged 60-95 years were recruited. Participants underwent the PPA (containing tests of contrast sensitivity, proprioception, quadriceps strength, reaction time and sway), and composite fall risk scores were computed. Participants were then followed up for falls for 1 year. Quadriceps strength and lower limb proprioception scores were comparable with those reported for Caucasian populations. However, contrast sensitivity, simple reaction time and postural sway scores were relatively poor. The average composite fall risk score was 1.7 ± 1.5, showing a "moderate" fall risk when compared with the Caucasian norms. Despite the relatively poor physical performances and moderately high fall risk scores, the incidence of one plus falls in the 1-year follow-up period was just 16.4%, with just 2.6% reporting two plus falls. The area under the curve for composite fall risk scores in discriminating fallers from non-fallers was 0.53 (95% CI 0.45-0.60). Despite poorer performance in PPA tests, the incidence of prospective falls in a Hong Kong Chinese population was low. In consequence, the PPA could not discriminate well between fallers and non-fallers. The present study provided normality data for short-form PPA measures for older Chinese people as a reference for further studies. © 2015 Japan Geriatrics Society.

  14. 40 CFR 73.14-73.17 - [Reserved (United States)


    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false [Reserved] 73.14-73.17 Section 73.14-73.17 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Allowance Allocations §§ 73.14-73.17 [Reserved] ...

  15. Colonic Fermentation: A Neglected Topic in Human Physiology Education (United States)

    Valeur, Jorgen; Berstad, Arnold


    Human physiology textbooks tend to limit their discussion of colonic functions to those of absorbing water and electrolytes and storing waste material. However, the colon is a highly active metabolic organ, containing an exceedingly complex society of microbes. By means of fermentation, gastrointestinal microbes break down nutrients that cannot be…

  16. First data on benthic and fish communities from the Mid-Atlantic Ridge, 16°40‧- 17°14‧N (United States)

    Molodtsova, Tina N.; Galkin, Sergey V.; Kobyliansky, Stanislav G.; Simakova, Ulyana V.; Vedenin, Andrey A.; Dobretsova, Irina G.; Gebruk, Andrey V.


    The first ecological survey in the tropical part of the northern Mid-Atlantic Ridge (MAR) was conducted between 17°14‧N and 16°40‧N in February-March 2015 during the 37th cruise of the RV Professor Logachev. Significant effort of the survey was aimed at studies of benthic non-vent soft sediment fauna at depths from 2270 m to 3900 m. Samples of this fauna at seven stations revealed 780 specimens and at least 136 species. The most common species was the hermit crab Parapagurus cf. nudus. Also common were the ophiuroids Ophiotypa simplex and Ophiomusium cf. lymani. Most benthic organisms were the depth range from 0 to 3850 m included 1128 specimens represented by 48 species from 16 families. The highest number of species was in the families Myctophidae (18), Gonostomatidae (9) and Sternoptychidae (5). In the course of the cruise, two new fields of massive sulphide deposits were discovered on the south-western slope of the seamount on the eastern flank of the rift valley, one at 17°08.7‧N and second at 17°07.45‧N. During video profiling in this area indications of modern hydrothermal activity were recorded. Extensive fields of shells of Bathymodiolus puteoserpentis and Thyasira sp. were discovered and samples of bivalves were taken using the TV-grab and geological square corer. Surprisingly high concentration of drowned pelagic algae Sargassum sp. (Phaeophyceae, Fucales) in different state of degradation was observed at TV transects at the seafloor both on soft and hard substrates. Thalli of Sargassum fluitans appeared in trawl catches. Massive aggregations of Sargassum also were abundant at the sea surface in the area from December 2014 to April 2015.

  17. Physiological arousal deficits in addicted gamers differ based on preferred game genre. (United States)

    Metcalf, Olivia; Pammer, Kristen


    There has been significant discussion surrounding the psychopathology of excessive gaming and whether it constitutes an addiction. The current study investigated physiological and subjective levels of arousal in gamers of two genres and the relationship between sensation seeking and gaming addiction. Heart rate (HR), blood pressure (BP) and skin conductance were recorded at baseline, during gaming for 15 min and after gaming in 30 massively multiplayer online role-playing game (MMORPG) and 30 first-person shooter (FPS) male gamers. Gamers were identified as addicted using the Addiction-Engagement Questionnaire. Sensation seeking was measured using the Arnett Inventory of Sensation Seeking. Addicted MMORPG gamers (n=16) displayed significant decreases in cardiovascular activity during gaming compared to baseline and showed significant increases after gaming. Addicted FPS gamers (n=13) had significant increases in BP during gaming which decreased significantly after gaming. In comparison, non-addicted MMORPG gamers (n=14) had significant decreases in HR during gaming, whereas BP in non-addicted MMORPG and FPS gamers (n=17) increased during gaming and after gaming. There were no significant relationships between sensation seeking and addiction. There are physiological arousal deficits in addicted gamers, and these patterns differ according to the genre of game played. Copyright © 2013 S. Karger AG, Basel.

  18. Creation retold: Use of Scripture and tradition in Sirach 16:24�17:14

    Directory of Open Access Journals (Sweden)

    Hulisani Ramantswana


    Full Text Available This article examines the use of Scripture and tradition in Sirach 16:24�17:14, which is a retelling of the creation stories. Ben Sira as an interpreter of Scripture utilised interpretive traditions or exegetical motifs that were in circulation during his time to provide instruction for his generation. His indebtedness to Scripture is evident from the quotations from Scripture and his use of scriptural language. In his retelling of the creation stories, he made use of the exegetical motifs that were in circulation, adapting them within the wisdom interpretive framework. He also rejected the tendency to blame evil on external agencies such as fallen angels and downplayed the gap between the creation process and the giving of the law at Sinai.Intradisciplinary and/or interdisciplinary implications: The article is an exegetical inquiry of the extra-biblical text of Ben Sira in dialogue with Scripture and with other exegetical traditions which were in circulation in the Second Temple period. The article highlights the indebtedness of Ben Sira to both Scripture and tradition, and also noting Ben Sira�s own creativity in the use of Scripture and tradition in his retelling of creation story

  19. Physical and Physiological Demands of Experienced Male Basketball Players During a Competitive Game. (United States)

    Puente, Carlos; Abián-Vicén, Javier; Areces, Francisco; López, Roberto; Del Coso, Juan


    Puente, C, Abián-Vicén, J, Areces, F, López, R, and Del Coso, J. Physical and physiological demands of experienced male basketball players during a competitive game. J Strength Cond Res 31(4): 956-962, 2017-The aim of this investigation was to analyze the physical and physiological demands of experienced basketball players during a real and competitive game. Twenty-five well-trained basketball players (8 guards, 8 forwards, and 9 centers) played a competitive game on an outdoor court. Instantaneous running speeds, the number of body impacts above 5 g, and the number of accelerations and decelerations were assessed by means of a 15-Hz global Positioning System accelerometer unit. Individual heart rate was also recorded using heart rate monitors. As a group mean, the basketball players covered 82.6 ± 7.8 m·min during the game with a mean heart rate of 89.8 ± 4.4% of maximal heart rate. Players covered 3 ± 3% of the total distance running at above 18 km·h and performed 0.17 ± 0.13 sprints per minute. The number of body impacts was 8.2 ± 1.8 per minute of play. The running pace of forwards was higher than that of centers (86.8 ± 6.2 vs. 76.6 ± 6.0 m·min; p ≤ 0.05). The maximal speed obtained during the game was significantly higher for guards than that for centers (24.0 ± 1.6 km·h vs. 21.3 ± 1.6 km·h; p ≤ 0.05). Centers performed a lower number of accelerations/decelerations than guards and forwards (p ≤ 0.05). In conclusion, the extraordinary rates of specific movements performed by these experienced basketball players indicate the high physiological demands necessary to be able to compete in this sport. The centers were the basketball players who showed lower physiological demands during a game, whereas there were no differences between guards and forwards. These results can be used by coaches to adapt basketball training programs to the specific demands of each playing position.

  20. Physiology in Medicine: Understanding dynamic alveolar physiology to minimize ventilator-induced lung injury. (United States)

    Nieman, Gary F; Satalin, Josh; Kollisch-Singule, Michaela; Andrews, Penny; Aiash, Hani; Habashi, Nader M; Gatto, Louis A


    Acute respiratory distress syndrome (ARDS) remains a serious clinical problem with the main treatment being supportive in the form of mechanical ventilation. However, mechanical ventilation can be a double-edged sword: if set improperly, it can exacerbate the tissue damage caused by ARDS; this is known as ventilator-induced lung injury (VILI). To minimize VILI, we must understand the pathophysiologic mechanisms of tissue damage at the alveolar level. In this Physiology in Medicine paper, the dynamic physiology of alveolar inflation and deflation during mechanical ventilation will be reviewed. In addition, the pathophysiologic mechanisms of VILI will be reviewed, and this knowledge will be used to suggest an optimal mechanical breath profile (MB P : all airway pressures, volumes, flows, rates, and the duration that they are applied at both inspiration and expiration) necessary to minimize VILI. Our review suggests that the current protective ventilation strategy, known as the "open lung strategy," would be the optimal lung-protective approach. However, the viscoelastic behavior of dynamic alveolar inflation and deflation has not yet been incorporated into protective mechanical ventilation strategies. Using our knowledge of dynamic alveolar mechanics (i.e., the dynamic change in alveolar and alveolar duct size and shape during tidal ventilation) to modify the MB P so as to minimize VILI will reduce the morbidity and mortality associated with ARDS. Copyright © 2017 the American Physiological Society.

  1. Physiological Event Prediction in Evaluations of Underwater Breathing Apparatus (United States)


    Navy Experimental Diving Unit TA 15-02 321 Bullfinch Rd. NEDU TR 16-04 Panama City, FL 32407-7015 October 2016 Physiological...Diving unit 321 Bullfinch Road Panama City, Florida 32407-7015 NEDU TR 16-04 9. SPONSORING / MONITORING AGENCY...varying dive conditions. The so-called maximum respiratory impedance model was calibrated on Navy manned dive results, and this paper describes the use

  2. Intra-articular sodium hyaluronate 2 mL versus physiological saline 20 mL versus physiological saline 2 mL for painful knee osteoarthritis: a randomized clinical trial

    DEFF Research Database (Denmark)

    Lundsgaard, C.; Dufour, N.; Fallentin, E.


    , Knee Injury and Osteoarthritis Outcome Score (KOOS), Osteoarthritis Research Society International (OARSI) criteria, and global assessment of the patient's condition. Results: The mean age of the patients was 69.4 years; 55% were women. The effects of hyaluronate 2 mL, physiological saline 20 m......Objective: Methodological constraints weaken previous evidence on intra-articular viscosupplementation and physiological saline distention for osteoarthritis. We conducted a randomized, patient- and observer-blind trial to evaluate these interventions in patients with painful knee osteoarthritis....... Methods: We centrally randomized 251 patients with knee ostcoarthritis to four weekly intra-articular injections of sodium hyaluronate 2 mL (Hyalgan(R) 10.3 mg/mL) versus physiological saline 20 mL (distention) versus physiological saline 2 mL (placebo) and followed patients for 26 weeks. Inclusion...

  3. Insomnia with physiological hyperarousal is associated with hypertension. (United States)

    Li, Yun; Vgontzas, Alexandros N; Fernandez-Mendoza, Julio; Bixler, Edward O; Sun, Yuanfeng; Zhou, Junying; Ren, Rong; Li, Tao; Tang, Xiangdong


    Previous studies have suggested that insomnia with objective short sleep duration is associated with a higher risk of hypertension, and it has been speculated that the underlying mechanism is physiological hyperarousal. In this study, we tested whether insomnia with physiological hyperarousal measured by Multiple Sleep Latency Test (MSLT), a standard test of sleepiness/alertness, is associated with increased risk of hypertension. Two hundred nineteen chronic insomniacs and 96 normal sleepers were included in this study. Chronic insomnia was defined based on standard diagnostic criteria with symptoms lasting ≥6 months. All subjects underwent 1 night in laboratory polysomnography followed by a standard MSLT. We used the median mean MSLT value (ie, >14 minutes) and the 75th percentile of mean MSLT value (ie, >17 minutes) to define hyperarousal. Hypertension was defined based either on blood pressure measures or on diagnosis treatment by a physician. After controlling for age, sex, body mass index, apnea-hypopnea index, diabetes mellitus, smoking, alcohol, and caffeine use, insomnia combined with MSLT >14 minutes increased the odds of hypertension by 300% (odds ratio=3.27; 95% confidence interval=1.20-8.96), whereas insomnia combined with MSLT >17 minutes increased even further the odds of hypertension by 400% (odds ratio=4.33; 95% confidence interval=1.48-12.68) compared with normal sleepers with MSLT ≤14 minutes. Insomnia associated with physiological hyperarousal is associated with a significant risk of hypertension. Long MSLT values may be a reliable index of the physiological hyperarousal and biological severity of chronic insomnia. © 2015 American Heart Association, Inc.

  4. An Individualized, Perception-Based Protocol to Investigate Human Physiological Responses to Cooling (United States)

    Coolbaugh, Crystal L.; Bush, Emily C.; Galenti, Elizabeth S.; Welch, E. Brian; Towse, Theodore F.


    Cold exposure, a known stimulant of the thermogenic effects of brown adipose tissue (BAT), is the most widely used method to study BAT physiology in adult humans. Recently, individualized cooling has been recommended to standardize the physiological cold stress applied across participants, but critical experimental details remain unclear. The purpose of this work was to develop a detailed methodology for an individualized, perception-based protocol to investigate human physiological responses to cooling. Participants were wrapped in two water-circulating blankets and fitted with skin temperature probes to estimate BAT activity and peripheral vasoconstriction. We created a thermoesthesia graphical user interface (tGUI) to continuously record the subject's perception of cooling and shivering status during the cooling protocol. The protocol began with a 15 min thermoneutral phase followed by a series of 10 min cooling phases and concluded when sustained shivering (>1 min duration) occurred. Researchers used perception of cooling feedback (tGUI ratings) to manually adjust and personalize the water temperature at each cooling phase. Blanket water temperatures were recorded continuously during the protocol. Twelve volunteers (ages: 26.2 ± 1.4 years; 25% female) completed a feasibility study to evaluate the proposed protocol. Water temperature, perception of cooling, and shivering varied considerably across participants in response to cooling. Mean clavicle skin temperature, a surrogate measure of BAT activity, decreased (−0.99°C, 95% CI: −1.7 to −0.25°C, P = 0.16) after the cooling protocol, but an increase in supraclavicular skin temperature was observed in 4 participants. A strong positive correlation was also found between thermoesthesia and peripheral vasoconstriction (ρ = 0.84, P < 0.001). The proposed individualized, perception-based protocol therefore has potential to investigate the physiological responses to cold stress applied across populations with

  5. Mapping of carbonic anhydrase and estrone sulphatase in rat brain using 16-α-[18F]fluoroestradiol-3,17-β-disulphamate ([18F]FESDS)

    International Nuclear Information System (INIS)

    Rodig, H.; Brust, P.; Bergmann, R.; Roemer, J.; Fuechtner, F.; Steinbach, J.; Kasch, H.


    16α-[ 18 F]Fluoroestradiol-3,17β-disulphamate ([ 18 F]FESDS) was recently found to display affinities to carbonic anhydrase (CA) and estrone sulphatase (ES), enzymes which are expressed in the CNS and probably play a regulatory role in various brain diseases. In this study the radioligand was used to provide quantitative data on the regional distribution of these enzymes in the rat brain. (orig.)

  6. Comparative gut physiology symposium: The microbe-gut-brain axis (United States)

    The Comparative Gut Physiology Symposium titled “The Microbe-Gut-Brain Axis” was held at the Joint Annual Meeting of the American Society of Animal Science and the American Dairy Science Association on Thursday, July 21, 2016, in Salt Lake City Utah. The goal of the symposium was to present basic r...

  7. The evolution of the Society for the Study of Ingestive Behavior (SSIB). (United States)

    Kissileff, Harry R; Ladenheim, Ellen


    This review summarizes the formation of the Society for the Study of Ingestive Behavior (SSIB), highlighting the many people whose commitment and perseverance brought together a wide range of disciplines for the common goal of investigating ingestive behavior and providing communication via scientific meetings. The goals and philosophy of the Society today are described along with the challenges it will face in the future. It concludes with the important message that excellence in science, combined with commitment to, and participation from, younger investigators, will ensure its continued success. The SSIB was officially incorporated on March 30, 1987 to serve a unique niche within the biological and behavioral sciences. Its initial vision was to serve as the "leading scientific organization for the study of ingestive behavior". This mission continues to drive the philosophy of the Society which currently boasts over 350 members representing 30 different countries. The SSIB melded scientific disciplines that included physiological and psychological aspects of food and fluid intake, as well as taste and olfaction. Prior to its creation, scientists from each of these disciplines met at several key conferences, most notably The International Conference on the Physiology of Food and Fluid Intake, a now defunct satellite of the International Union of Physiological Sciences, and The Eastern Psychological Association. From these and other smaller conferences came the idea of forming a society that integrated research from the biological, psychological and social aspects of food and fluid intake in both animals and humans. While this emphasis of the Society remains today, changing scientific priorities and interests continue to shape and influence the direction of the Society. Since its first meeting held at Princeton University in NJ in 1992, the annual meeting has become a major means of disseminating cutting-edge information on current research in the field of

  8. Back to the future! Revisiting the physiological cost of negative work as a team-based activity for exercise physiology students. (United States)

    Kilgas, Matthew A; Elmer, Steven J


    We implemented a team-based activity in our exercise physiology teaching laboratory that was inspired from Abbott et al.'s classic 1952 Journal of Physiology paper titled "The physiological cost of negative work." Abbott et al. connected two bicycles via one chain. One person cycled forward (muscle shortening contractions, positive work) while the other resisted the reverse moving pedals (muscle lengthening contractions, negative work), and the cost of work was compared. This study was the first to link human whole body energetics with isolated muscle force-velocity characteristics. The laboratory activity for our students ( n = 35) was designed to reenact Abbott et al.'s experiment, integrate previously learned techniques, and illustrate differences in physiological responses to muscle shortening and lengthening contractions. Students (11-12 students/laboratory section) were split into two teams (positive work vs. negative work). One student from each team volunteered to cycle against the other for ~10 min. The remaining students in each team were tasked with measuring: 1 ) O 2 consumption, 2 ) heart rate, 3 ) blood lactate, and 4 ) perceived exertion. Students discovered that O 2 consumption during negative work was about one-half that of positive work and all other physiological parameters were also substantially lower. Muscle lengthening contractions were discussed and applied to rehabilitation and sport training. The majority of students (>90%) agreed or strongly agreed that they stayed engaged during the activity and it improved their understanding of exercise physiology. All students recommended the activity be performed again. This activity was engaging, emphasized teamwork, yielded clear results, was well received, and preserved the history of classic physiological experiments. Copyright © 2017 the American Physiological Society.

  9. The influence of physiological and surgical menopause on coronary heart disease risk markers

    NARCIS (Netherlands)

    Verhoeven, Marieke O.; van der Mooren, Marius J.; Teerlink, Tom; Verheijen, Rene H. M.; Scheffer, Peter G.; Kenemans, Peter


    Objective: To investigate the influence of physiological and surgical menopause oil Serum concentrations of corollary heart disease (CHD) risk markers and sex hormones. Design: Physiological menopausal transition was investigated in two studies. In a longitudinal Study, 16 women were followed from 2

  10. Causes of Low and High Citation Potentials in Science: Citation Analysis of Biochemistry and Plant Physiology Journals. (United States)

    Marton, Janos


    Citation data of 16 biochemistry and plant physiology journals show that reasons for lower citation potentials of plant physiology articles are: (1) readership is narrower for plant physiology journals; (2) plant physiologists can cite fewer thematically relevant new articles; and (3) plant physiology research fields are more isolated. References…

  11. Central role of T helper 17 cells in chronic hypoxia-induced pulmonary hypertension. (United States)

    Maston, Levi D; Jones, David T; Giermakowska, Wieslawa; Howard, Tamara A; Cannon, Judy L; Wang, Wei; Wei, Yongyi; Xuan, Weimin; Resta, Thomas C; Gonzalez Bosc, Laura V


    Inflammation is a prominent pathological feature in pulmonary arterial hypertension, as demonstrated by pulmonary vascular infiltration of inflammatory cells, including T and B lymphocytes. However, the contribution of the adaptive immune system is not well characterized in pulmonary hypertension caused by chronic hypoxia. CD4 + T cells are required for initiating and maintaining inflammation, suggesting that these cells could play an important role in the pathogenesis of hypoxic pulmonary hypertension. Our objective was to test the hypothesis that CD4 + T cells, specifically the T helper 17 subset, contribute to chronic hypoxia-induced pulmonary hypertension. We compared indices of pulmonary hypertension resulting from chronic hypoxia (3 wk) in wild-type mice and recombination-activating gene 1 knockout mice (RAG1 -/- , lacking mature T and B cells). Separate sets of mice were adoptively transferred with CD4 + , CD8 + , or T helper 17 cells before normoxic or chronic hypoxic exposure to evaluate the involvement of specific T cell subsets. RAG1 -/- mice had diminished right ventricular systolic pressure and arterial remodeling compared with wild-type mice exposed to chronic hypoxia. Adoptive transfer of CD4 + but not CD8 + T cells restored the hypertensive phenotype in RAG1 -/- mice. Interestingly, RAG1 -/- mice receiving T helper 17 cells displayed evidence of pulmonary hypertension independent of chronic hypoxia. Supporting our hypothesis, depletion of CD4 + cells or treatment with SR1001, an inhibitor of T helper 17 cell development, prevented increased pressure and remodeling responses to chronic hypoxia. We conclude that T helper 17 cells play a key role in the development of chronic hypoxia-induced pulmonary hypertension. Copyright © 2017 the American Physiological Society.

  12. APS: 125 Years of Progress of Physiology as a Scientific Discipline and a Profession (United States)

    Carroll, Robert G.; Frank, Martin; Ra'anan, Alice; Matyas, Marsha L.


    The Experimental Biology 2012 meeting in San Diego, CA, included events to celebrate the 125th anniversary of the founding of the American Physiological Society (APS) and reflect on the recent accomplishments of the society. Most of the APS activities in the past quarter century were guided by a series of strategic plans. Membership in the APS…

  13. The Physiology Undergraduate Major in the University of Arizona College of Medicine: Past, Present, and Future (United States)

    Henriksen, Erik J.; Atwater, Anne E.; Delamere, Nicholas A.; Dantzler, William H.


    The American Physiological Society (APS) and APS Council encourage the teaching of physiology at the undergraduate, graduate, and medical school levels to support the continued prominence of this area of science. One area identified by the APS Council that is of particular importance for the development of future physiologists (the…

  14. Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1.

    Directory of Open Access Journals (Sweden)

    Alexandr N Simonov

    Full Text Available Cytochrome P450c17 (P450 17A1, CYP17A1 is a critical enzyme in the synthesis of androgens and is now a target enzyme for the treatment of prostate cancer. Cytochrome P450c17 can exhibit either one or two physiological enzymatic activities differentially regulated by cytochrome b5. How this is achieved remains unknown. Here, comprehensive in silico, in vivo and in vitro analyses were undertaken. Fluorescence Resonance Energy Transfer analysis showed close interactions within living cells between cytochrome P450c17 and cytochrome b5. In silico modeling identified the sites of interaction and confirmed that E48 and E49 residues in cytochrome b5 are essential for activity. Quartz crystal microbalance studies identified specific protein-protein interactions in a lipid membrane. Voltammetric analysis revealed that the wild type cytochrome b5, but not a mutated, E48G/E49G cyt b5, altered the kinetics of electron transfer between the electrode and the P450c17. We conclude that cytochrome b5 can influence the electronic conductivity of cytochrome P450c17 via allosteric, protein-protein interactions.

  15. Zinc: physiology, deficiency, and parenteral nutrition. (United States)

    Livingstone, Callum


    The essential trace element zinc (Zn) has a large number of physiologic roles, in particular being required for growth and functioning of the immune system. Adaptive mechanisms enable the body to maintain normal total body Zn status over a wide range of intakes, but deficiency can occur because of reduced absorption or increased gastrointestinal losses. Deficiency impairs physiologic processes, leading to clinical consequences that include failure to thrive, skin rash, and impaired wound healing. Mild deficiency that is not clinically overt may still cause nonspecific consequences, such as susceptibility to infection and poor growth. The plasma Zn concentration has poor sensitivity and specificity as a test of deficiency. Consequently, diagnosis of deficiency requires a combination of clinical assessment and biochemical tests. Patients receiving parenteral nutrition (PN) are susceptible to Zn deficiency and its consequences. Nutrition support teams should have a strategy for assessing Zn status and optimizing this by appropriate supplementation. Nutrition guidelines recommend generous Zn provision from the start of PN. This review covers the physiology of Zn, the consequences of its deficiency, and the assessment of its status, before discussing its role in PN. © 2015 American Society for Parenteral and Enteral Nutrition.

  16. Physiology and Endocrinology Symposium. Factors controlling puberty in beef heifers (United States)

    The Physiology and Endocrinology Symposium on “Factors controlling puberty in beef heifers” was held at the joint annual meeting of the American Dairy Science Association and the American Society of Animal Science in New Orleans, Louisiana, USA, July 10 to 14, 2011. The objective of the symposium w...

  17. Physiological Ripples (± 100 Hz) in Spike-Free Scalp EEGs of Children With and Without Epilepsy. (United States)

    Mooij, Anne H; Raijmann, Renee C M A; Jansen, Floor E; Braun, Kees P J; Zijlmans, Maeike


    Pathological high frequency oscillations (HFOs, >80 Hz) are considered new biomarkers for epilepsy. They have mostly been recorded invasively, but pathological ripples (80-250 Hz) can also be found in scalp EEGs with frequent epileptiform spikes. Physiological HFOs also exist. They have been recorded invasively in hippocampus and neocortex. There are no reports of spontaneously occurring physiological HFOs recorded with scalp EEG. We aimed to study ripples in spike-free scalp EEGs. We included 23 children (6 with, 17 without epilepsy) who had an EEG without interictal epileptiform spikes recorded during sleep. We differentiated true ripples from spurious ripples such as filtering effects of sharp artifacts and high frequency components of muscle artifacts by viewing ripples simultaneously in bipolar and average montage and double-checking the unfiltered signal. We calculated mean frequency, duration and root mean square amplitude of the ripples, and studied their shape and distribution. We found ripples in EEGs of 20 out of 23 children (4 with, 16 without epilepsy). Ripples had a regular shape and occurred mostly on central and midline channels. Mean frequency was 102 Hz, mean duration 70 ms, mean root mean square amplitude 0.95 µV. Ripples occurring in normal EEGs of children without epilepsy were considered physiological; the similarity in appearance suggested that the ripples occurring in normal EEGs of children with epilepsy were also physiological. The finding that it is possible to study physiological neocortical ripples in scalp EEG paves the way for investigating their occurrence during brain development and their relation with cognitive functioning.

  18. Changing undergraduate human anatomy and physiology laboratories: perspectives from a large-enrollment course. (United States)

    Griff, Edwin R


    In the present article, a veteran lecturer of human anatomy and physiology taught several sections of the laboratory component for the first time and shares his observations and analysis from this unique perspective. The article discusses a large-enrollment, content-heavy anatomy and physiology course in relationship to published studies on learning and student self-efficacy. Changes in the laboratory component that could increase student learning are proposed. The author also points out the need for research to assess whether selective curricular changes could increase the depth of understanding and retention of learned material. Copyright © 2016 The American Physiological Society.

  19. Antenatal betamethasone attenuates the angiotensin-(1-7)-Mas receptor-nitric oxide axis in isolated proximal tubule cells. (United States)

    Su, Yixin; Bi, Jianli; Pulgar, Victor M; Chappell, Mark C; Rose, James C


    We previously reported a sex-specific effect of antenatal treatment with betamethasone (Beta) on sodium (Na + ) excretion in adult sheep whereby treated males but not females had an attenuated natriuretic response to angiotensin-(1-7) [Ang-(1-7)]. The present study determined the Na + uptake and nitric oxide (NO) response to low-dose Ang-(1-7) (1 pM) in renal proximal tubule cells (RPTC) from adult male and female sheep antenatally exposed to Beta or vehicle. Data were expressed as percentage of basal uptake or area under the curve for Na + or percentage of control for NO. Male Beta RPTC exhibited greater Na + uptake than male vehicle cells (433 ± 28 vs. 330 ± 26%; P 0.05). Ang-(1-7) significantly inhibited Na + uptake in RPTC from vehicle male (214 ± 11%) and from both vehicle (190 ± 14%) and Beta (209 ± 11%) females but failed to attenuate Na + uptake in Beta male cells. Beta exposure also abolished stimulation of NO by Ang-(1-7) in male but not female RPTC. Both the Na + and NO responses to Ang-(1-7) were blocked by Mas receptor antagonist d-Ala 7 -Ang-(1-7). We conclude that the tubular Ang-(1-7)-Mas-NO pathway is attenuated in males and not females by antenatal Beta exposure. Moreover, since primary cultures of RPTC retain both the sex and Beta-induced phenotype of the adult kidney in vivo they appear to be an appropriate cell model to examine the effects of fetal programming on Na + handling by the renal tubules. Copyright © 2017 the American Physiological Society.

  20. Physiology, production and action of progesterone. (United States)

    Taraborrelli, Stefania


    The aim of this article is to review the physiology of progesterone and focus on its physiological actions on tissues such as endometrium, uterus, mammary gland, cardiovascular system, central nervous system and bones. In the last decades, the interest of researchers has focused on the role of progesterone in genomic and non-genomic receptor mechanisms. We searched PubMed up to December 2014 for publications on progesterone/steroidogenesis. A better understanding of the biological genomic and non-genomic receptor mechanisms could enable us in the near future to obtain a more comprehensive knowledge of the safety and efficacy of this agent during hormone replacement therapy (natural progesterone), in vitro fertilization (water-soluble subcutaneous progesterone), in traumatic brain injury, Alzheimer's disease and diabetic neuropathy, even though further clinical studies are needed to prove its usefulness. © 2015 Nordic Federation of Societies of Obstetrics and Gynecology.

  1. Linking Insects with Crustacea: Physiology of the Pancrustacea: An Introduction to the Symposium. (United States)

    Tamone, Sherry L; Harrison, Jon F


    Insects and crustaceans represent critical, dominant animal groups (by biomass and species number) in terrestrial and aquatic systems, respectively. Insects (hexapods) and crustaceans are historically grouped under separate taxonomic classes within the Phylum Arthropoda, and the research communities studying hexapods and crustaceans are quite distinct. More recently, the hexapods have been shown to be evolutionarily derived from basal crustaceans, and the clade Pancrustacea recognizes this relationship. This recent evolutionary perspective, and the fact that the Society for Integrative and Comparative Biology has strong communities in both invertebrate biology and insect physiology, provides the motivation for this symposium. Speakers in this symposium were selected because of their expertise in a particular field of insect or crustacean physiology, and paired in such a way as to provide a comparative view of the state of the current research in their respective fields. Presenters discussed what aspects of the physiological system are clearly conserved across insects and crustaceans and how cross-talk between researchers utilizing insects and crustaceans can fertilize understanding of such conserved systems. Speakers were also asked to identify strategies that would enable improved understanding of the evolution of physiological systems of the terrestrial insects from the aquatic crustaceans. The following collection of articles describes multiple recent advances in our understanding of Pancrustacean physiology. © The Author 2015. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email:

  2. Human Adaptation to Space: Space Physiology and Countermeasures (United States)

    Fogarty, Jennifer


    This viewgraph presentation reviews human physiological responses to spaceflight, and the countermeasures taken to prevent adverse effects of manned space flight. The topics include: 1) Human Spaceflight Experience; 2) Human Response to Spaceflight; 3) ISS Expeditions 1-16; 4) Countermeasure; and 5) Biomedical Data;

  3. DesignLAK17

    DEFF Research Database (Denmark)

    Ringtved, Ulla; Milligan, Sandra; Corrin, Linda


    Notions of what constitutes quality in design in traditional on-campus or online teaching and learning may not always translate into scaled digital environments. The DesignLAK17 workshop builds on the DesignLAK16 workshop to explore one aspect of this theme, namely the opportunities arising from...

  4. Getting to the Outer Leaflet: Physiology of Phosphatidylserine Exposure at the Plasma Membrane. (United States)

    Bevers, Edouard M; Williamson, Patrick L


    Phosphatidylserine (PS) is a major component of membrane bilayers whose change in distribution between inner and outer leaflets is an important physiological signal. Normally, members of the type IV P-type ATPases spend metabolic energy to create an asymmetric distribution of phospholipids between the two leaflets, with PS confined to the cytoplasmic membrane leaflet. On occasion, membrane enzymes, known as scramblases, are activated to facilitate transbilayer migration of lipids, including PS. Recently, two proteins required for such randomization have been identified: TMEM16F, a scramblase regulated by elevated intracellular Ca(2+), and XKR8, a caspase-sensitive protein required for PS exposure in apoptotic cells. Once exposed at the cell surface, PS regulates biochemical reactions involved in blood coagulation, and bone mineralization, and also regulates a variety of cell-cell interactions. Exposed on the surface of apoptotic cells, PS controls their recognition and engulfment by other cells. This process is exploited by parasites to invade their host, and in specialized form is used to maintain photoreceptors in the eye and modify synaptic connections in the brain. This review discusses what is known about the mechanism of PS exposure at the surface of the plasma membrane of cells, how actors in the extracellular milieu sense surface exposed PS, and how this recognition is translated to downstream consequences of PS exposure. Copyright © 2016 the American Physiological Society.

  5. The vaginal microbiota, host defence and reproductive physiology. (United States)

    Smith, Steven B; Ravel, Jacques


    The interaction between the human host and the vaginal microbiota is highly dynamic. Major changes in the vaginal physiology and microbiota over a woman's lifetime are largely shaped by transitional periods such as puberty, menopause and pregnancy, while daily fluctuations in microbial composition observed through culture-independent studies are more likely to be the results of daily life activities and behaviours. The vaginal microbiota of reproductive-aged women is largely made up of at least five different community state types. Four of these community state types are dominated by lactic-acid producing Lactobacillus spp. while the fifth is commonly composed of anaerobes and strict anaerobes and is sometimes associated with vaginal symptoms. The production of lactic acid has been associated with contributing to the overall health of the vagina due to its direct and indirect effects on pathogens and host defence. Some species associated with non-Lactobacillus vaginal microbiota may trigger immune responses as well as degrade the host mucosa, processes that ultimately increase susceptibility to infections and contribute to negative reproductive outcomes such as infertility and preterm birth. Further studies are needed to better understand the functional underpinnings of how the vaginal microbiota affect host physiology but also how host physiology affects the vaginal microbiota. Understanding this fine-tuned interaction is key to maintaining women's reproductive health. © 2016 The Authors. The Journal of Physiology © 2016 The Physiological Society.

  6. Using physiologically based models for clinical translation: predictive modelling, data interpretation or something in-between? (United States)

    Niederer, Steven A; Smith, Nic P


    Heart disease continues to be a significant clinical problem in Western society. Predictive models and simulations that integrate physiological understanding with patient information derived from clinical data have huge potential to contribute to improving our understanding of both the progression and treatment of heart disease. In particular they provide the potential to improve patient selection and optimisation of cardiovascular interventions across a range of pathologies. Currently a significant proportion of this potential is still to be realised. In this paper we discuss the opportunities and challenges associated with this realisation. Reviewing the successful elements of model translation for biophysically based models and the emerging supporting technologies, we propose three distinct modes of clinical translation. Finally we outline the challenges ahead that will be fundamental to overcome if the ultimate goal of fully personalised clinical cardiac care is to be achieved. © 2016 The Authors. The Journal of Physiology © 2016 The Physiological Society.

  7. Beta-delayed particle decay of 17Ne

    International Nuclear Information System (INIS)

    Morton, A.C.; Chow, J.C.; King, J.D.; Boyd, R.N.; Bateman, N.P.T.; Buchmann, L.; D'Auria, J.M.; Davinson, T.; Dombsky, M.; Galster, W.; Gete, E.; Giesen, U.; Iliadis, C.; Jackson, K.P.; Powell, J.; Roy, G.; Shotter, A.


    The β-delayed particle decay of 17 Ne has been studied via proton-γ coincidences, time-of-flight measurements and the ''ratio-cut technique'', allowing cleanly-separated proton and α-particle spectra to be obtained. A complete set of proton and α branching ratios for the decay of 14 excited states in 17 F to the ground and excited states of 16 O and 13 N has been determined and branching ratios for the β decay of 17 Ne to these states have been deduced. From the branching ratios, f A t values and reduced Gamow-Teller matrix elements were calculated; no indication of isospin mixing in the isobaric analog state in 17 F was observed. From the measurement of proton-γ angular correlations, combined with the selection rules for an allowed β decay, we obtain J π =((1)/(2)) - for states at 8.436 and 9.450 MeV and ((3)/(2)) - for the state at 10.030 MeV in 17 F. Probabilities for the β-delayed pα decay to 12 C through the tails of the subthreshold 7.117 and 6.917 MeV states in 16 O have been calculated and the feasibility of using such decays to provide information about the rates for the E1 and E2 components of the 12 C(α,γ) 16 O reaction is discussed

  8. Variable setpoint as a relaxing component in physiological control. (United States)

    Risvoll, Geir B; Thorsen, Kristian; Ruoff, Peter; Drengstig, Tormod


    Setpoints in physiology have been a puzzle for decades, and especially the notion of fixed or variable setpoints have received much attention. In this paper, we show how previously presented homeostatic controller motifs, extended with saturable signaling kinetics, can be described as variable setpoint controllers. The benefit of a variable setpoint controller is that an observed change in the concentration of the regulated biochemical species (the controlled variable) is fully characterized, and is not considered a deviation from a fixed setpoint. The variation in this biochemical species originate from variation in the disturbances (the perturbation), and thereby in the biochemical species representing the controller (the manipulated variable). Thus, we define an operational space which is spanned out by the combined high and low levels of the variations in (1) the controlled variable, (2) the manipulated variable, and (3) the perturbation. From this operational space, we investigate whether and how it imposes constraints on the different motif parameters, in order for the motif to represent a mathematical model of the regulatory system. Further analysis of the controller's ability to compensate for disturbances reveals that a variable setpoint represents a relaxing component for the controller, in that the necessary control action is reduced compared to that of a fixed setpoint controller. Such a relaxing component might serve as an important property from an evolutionary point of view. Finally, we illustrate the principles using the renal sodium and aldosterone regulatory system, where we model the variation in plasma sodium as a function of salt intake. We show that the experimentally observed variations in plasma sodium can be interpreted as a variable setpoint regulatory system. © 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

  9. Structure-function relations in physiology education: Where's the mechanism? (United States)

    Lira, Matthew E; Gardner, Stephanie M


    Physiology demands systems thinking: reasoning within and between levels of biological organization and across different organ systems. Many physiological mechanisms explain how structures and their properties interact at one level of organization to produce emergent functions at a higher level of organization. Current physiology principles, such as structure-function relations, selectively neglect mechanisms by not mentioning this term explicitly. We explored how students characterized mechanisms and functions to shed light on how students make sense of these terms. Students characterized mechanisms as 1 ) processes that occur at levels of organization lower than that of functions; and 2 ) as detailed events with many steps involved. We also found that students produced more variability in how they characterized functions compared with mechanisms: students characterized functions in relation to multiple levels of organization and multiple definitions. We interpret these results as evidence that students see mechanisms as holding a more narrow definition than used in the biological sciences, and that students struggle to coordinate and distinguish mechanisms from functions due to cognitive processes germane to learning in many domains. We offer the instructional suggestion that we scaffold student learning by affording students opportunities to relate and also distinguish between these terms so central to understanding physiology. Copyright © 2017 the American Physiological Society.

  10. Aging obviates sex-specific physiological responses to exercise. (United States)

    Deschenes, Michael R; Taylor, Jessica L; Mangis, Katherine A


    Both sex and aging have been shown to affect physiological responses to exercise. The aim of the present investigation was to determine whether aging impacted the sex-specific nature of physiological responses to exercise commonly noted among young adults. Ten aged men (69.0 ± 1.7 years; mean ± SE) and 10 aged women (71.6 ± 1.3 years) reporting similar levels of habitual physical activity performed a 30-min exercise session at 60-65% of their predetermined peak oxygen uptake. Cardiovascular, thermoregulatory, and metabolic variables were assessed before exercise, at the 15th and 30th min of exercise, and at 5 and 15 min into a passive postexercise recovery period. Variables of interest were statistically analyzed via two-way analysis of variance with repeated measures; significance was set at P physiological variable of interest were identified, but not once was a significant effect of group (i.e., sex) detected. Exercise-induced physiological responses to prolonged, moderate intensity exercise were similar among aged men and aged women. This evidence that the sexually dimorphic nature of physiological responses to exercise is obviated with age should be taken into account when prescribing health-related exercise training programs for older individuals. Copyright © 2013 Wiley Periodicals, Inc.

  11. The influence of low frequency magnetic field upon cultivable plant physiology

    International Nuclear Information System (INIS)

    Rochalska, M.


    The 16 Hz frequency and 5 mT magnetic flux density as well as alternating magnetic field influence the field germination physiological yield-forming features and the yield of sugar have been investigated. The profitable influence of the investigated factor at physiological yield-forming features, causing an increase in sugar beet root and leaf yield, was shown. The beneficial influence on the yield is especially clear in unfavourable weather conditions. (author)

  12. Chemical data from bottle casts in the Arctic Ocean and other Sea areas by the University of Alaska, from 16 April 1948 to 17 September 2000 (NODC Accession 0000918) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Chemical data were collected using bottle casts from multiple vessels in the Arctic Ocean and other Sea areas from 16 April 1948 to 17 September 2000. Data were...

  13. Materials of yearly scientific assembly of Polish Chemical Society, Poznan 23-26 September 1996

    International Nuclear Information System (INIS)


    The Scientific Assembly of Polish Chemical Society has been held in 1996 in Poznan. The general view on scientific progress of chemistry in Poland has been presented. The conference has been divided into 18 sessions covering the most important research fields in chemistry. The sessions topics were as follows: S-1 physical chemistry; S-2 photochemistry, radiation chemistry and chemical kinetics; S-3 catalysis; S-4 inorganic chemistry and coordination chemistry; S-5 organic chemistry; S-6 chemistry of hetero organic compounds; S-7 medical chemistry; S-8 crystallochemistry; S-9 environment protection; S-10 didactics in chemistry; S-11 analytical chemistry; S-12 chemical technology; S-13 chemical engineering; S-14 chemistry of polymers; S-15 young chemists forum; S-16 professor forum; S-17 membranes and membrane processes; S-18 supermolecular chemistry

  14. 17 CFR 270.8b-16 - Amendments to registration statement. (United States)


    ... company's investment objectives or policies (described in Item 8.2 of Form N-2) that have not been... (CONTINUED) RULES AND REGULATIONS, INVESTMENT COMPANY ACT OF 1940 § 270.8b-16 Amendments to registration statement. (a) Every registered management investment company which is required to file a semi-annual report...

  15. A day of immersive physiology experiments increases knowledge and excitement towards physiology and scientific careers in Native American students. (United States)

    Becker, Bryan K; Schiller, Alicia M; Zucker, Irving H; Eager, Eric A; Bronner, Liliana P; Godfrey, Maurice


    Underserved minority groups are disproportionately absent from the pursuit of careers in science, technology, engineering, and mathematics (STEM) fields. One such underserved population, Native Americans, are particularly underrepresented in STEM fields. Although recent advocacy and outreach designed toward increasing minority involvement in health care-related occupations have been mostly successful, little is known about the efficacy of outreach programs in increasing minority enthusiasm toward careers in traditional scientific professions. Furthermore, very little is known about outreach among Native American schools toward increasing involvement in STEM. We collaborated with tribal middle and high schools in South Dakota and Nebraska through a National Institutes of Health Science Education Partnership Award to hold a day-long physiology, activity-based event to increase both understanding of physiology and enthusiasm to scientific careers. We recruited volunteer biomedical scientists and trainees from the University of Nebraska Medical Center, Nebraska Wesleyan University, and University of South Dakota. To evaluate the effectiveness of the day of activities, 224 of the ~275-300 participating students completed both a pre- and postevent evaluation assessment. We observed increases in both students self-perceived knowledge of physiology and enthusiasm toward scientific career opportunities after the day of outreach activities. We conclude that activity-based learning opportunities in underserved populations are effective in increasing both knowledge of science and interest in scientific careers. Copyright © 2017 the American Physiological Society.

  16. Resolving an 80-yr-old controversy: the beginning of the modern era of renal physiology. (United States)

    Jamison, Rex L


    Marcello Malpighi discovered the glomerulus that bears his name in the 17th century, but it was not until the middle of the 19th century, in 1842, that William Bowman in London published his studies of the histological structure of the glomerulus and proposed that urine formation begins with glomerular secretion. At nearly the same time in Marburg, Carl Ludwig, unaware of Bowman's findings, proposed that urine formation begins with glomerular filtration followed by tubule reabsorption. The controversy lasted 80 yr. Prominent investigators weighed in on both sides. Rudolph Heidenhain's findings in 1874 swung the pendulum toward Bowman's theory until Arthur Cushny published his book, The Secretion of Urine, in 1917, in which he found the evidence insufficient to prove either theory. In 1921, a young physician, Joseph Wearn, began his postresidency training in the laboratory of Alfred N. Richards. He read Cushny's book and learned how to expose the glomerulus of a living frog. Richards proposed that Wearn use that experimental preparation to inject epinephrine into the glomerulus. Wearn proposed a different experiment: instead of using injection, collect fluid from the glomerulus and analyze it. Richards agreed, and the landmark results of that experiment, published in 1924, settled the controversy. The modern era of renal physiology was born. Copyright © 2014 The American Physiological Society.

  17. New concepts in white adipose tissue physiology

    International Nuclear Information System (INIS)

    Proença, A.R.G.; Sertié, R.A.L.; Oliveira, A.C.; Campaãa, A.B.; Caminhotto, R.O.; Chimin, P.; Lima, F.B.


    Numerous studies address the physiology of adipose tissue (AT). The interest surrounding the physiology of AT is primarily the result of the epidemic outburst of obesity in various contemporary societies. Briefly, the two primary metabolic activities of white AT include lipogenesis and lipolysis. Throughout the last two decades, a new model of AT physiology has emerged. Although AT was considered to be primarily an abundant energy source, it is currently considered to be a prolific producer of biologically active substances, and, consequently, is now recognized as an endocrine organ. In addition to leptin, other biologically active substances secreted by AT, generally classified as cytokines, include adiponectin, interleukin-6, tumor necrosis factor-alpha, resistin, vaspin, visfatin, and many others now collectively referred to as adipokines. The secretion of such biologically active substances by AT indicates its importance as a metabolic regulator. Cell turnover of AT has also recently been investigated in terms of its biological role in adipogenesis. Consequently, the objective of this review is to provide a comprehensive critical review of the current literature concerning the metabolic (lipolysis, lipogenesis) and endocrine actions of AT

  18. New concepts in white adipose tissue physiology

    Energy Technology Data Exchange (ETDEWEB)

    Proença, A.R.G. [Universidade Estadual de Campinas, Laboratório de Biotecnologia, Faculdade de Ciências Aplicadas, Limeira, SP, Brasil, Laboratório de Biotecnologia, Faculdade de Ciências Aplicadas, Universidade Estadual de Campinas, Limeira, SP (Brazil); Sertié, R.A.L. [Universidade de São Paulo, Instituto de Ciências Biomédicas, Departamento de Fisiologia e Biofísica, São Paulo, SP, Brasil, Departamento de Fisiologia e Biofísica, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP (Brazil); Oliveira, A.C. [Universidade Estadual do Ceará, Instituto Superior de Ciências Biomédicas, Fortaleza, CE, Brasil, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, CE (Brazil); Campaãa, A.B.; Caminhotto, R.O.; Chimin, P.; Lima, F.B. [Universidade de São Paulo, Instituto de Ciências Biomédicas, Departamento de Fisiologia e Biofísica, São Paulo, SP, Brasil, Departamento de Fisiologia e Biofísica, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP (Brazil)


    Numerous studies address the physiology of adipose tissue (AT). The interest surrounding the physiology of AT is primarily the result of the epidemic outburst of obesity in various contemporary societies. Briefly, the two primary metabolic activities of white AT include lipogenesis and lipolysis. Throughout the last two decades, a new model of AT physiology has emerged. Although AT was considered to be primarily an abundant energy source, it is currently considered to be a prolific producer of biologically active substances, and, consequently, is now recognized as an endocrine organ. In addition to leptin, other biologically active substances secreted by AT, generally classified as cytokines, include adiponectin, interleukin-6, tumor necrosis factor-alpha, resistin, vaspin, visfatin, and many others now collectively referred to as adipokines. The secretion of such biologically active substances by AT indicates its importance as a metabolic regulator. Cell turnover of AT has also recently been investigated in terms of its biological role in adipogenesis. Consequently, the objective of this review is to provide a comprehensive critical review of the current literature concerning the metabolic (lipolysis, lipogenesis) and endocrine actions of AT.

  19. Validation of the AVITA BPM17 wrist blood pressure monitor for home blood pressure monitoring according to the European Society of Hypertension International Protocol revision 2010. (United States)

    Kang, Yuan-Yuan; Chen, Qi; Liu, Chang-Yuan; Li, Yan; Wang, Ji-Guang


    The aim of the present study was to evaluate the accuracy of the automated oscillometric wrist blood pressure monitor AVITA BPM17 for home blood pressure monitoring according to the International Protocol of the European Society of Hypertension revision 2010. Systolic and diastolic blood pressures were sequentially measured in 33 adult Chinese (19 men, 45.7 years of mean age) using a mercury sphygmomanometer (two observers) and the AVITA BPM17 device (one supervisor). Ninety-nine pairs of comparisons were obtained from 33 participants for judgments in two parts with three grading phases. The AVITA BPM17 device achieved the targets in part 1 of the validation study. The number of absolute differences between device and observers within 5, 10, and 15 mmHg was 94/99, 98/99, and 98/99, respectively, for systolic blood pressure and 92/99, 99/99, and 99/99, respectively, for diastolic blood pressure. The device also fulfilled the criteria in part 2 of the validation study. Overall, 32 participants for both systolic and diastolic blood pressure, respectively, had at least two of the three device-observerss differences within 5 mmHg (required ≥24). None had all the three device-observers comparisons greater than 5 mmHg for systolic and diastolic blood pressure. The AVITA wrist blood pressure monitor BPM17 has passed the requirements of the International Protocol revision 2010, and hence can be recommended for home use in adults.

  20. Functional physiology of the human terminal antrum defined by high-resolution electrical mapping and computational modeling. (United States)

    Berry, Rachel; Miyagawa, Taimei; Paskaranandavadivel, Niranchan; Du, Peng; Angeli, Timothy R; Trew, Mark L; Windsor, John A; Imai, Yohsuke; O'Grady, Gregory; Cheng, Leo K


    High-resolution (HR) mapping has been used to study gastric slow-wave activation; however, the specific characteristics of antral electrophysiology remain poorly defined. This study applied HR mapping and computational modeling to define functional human antral physiology. HR mapping was performed in 10 subjects using flexible electrode arrays (128-192 electrodes; 16-24 cm 2 ) arranged from the pylorus to mid-corpus. Anatomical registration was by photographs and anatomical landmarks. Slow-wave parameters were computed, and resultant data were incorporated into a computational fluid dynamics (CFD) model of gastric flow to calculate impact on gastric mixing. In all subjects, extracellular mapping demonstrated normal aboral slow-wave propagation and a region of increased amplitude and velocity in the prepyloric antrum. On average, the high-velocity region commenced 28 mm proximal to the pylorus, and activation ceased 6 mm from the pylorus. Within this region, velocity increased 0.2 mm/s per mm of tissue, from the mean 3.3 ± 0.1 mm/s to 7.5 ± 0.6 mm/s (P human terminal antral contraction is controlled by a short region of rapid high-amplitude slow-wave activity. Distal antral wave acceleration plays a major role in antral flow and mixing, increasing particle strain and trituration. Copyright © 2016 the American Physiological Society.

  1. First-forbidden mirror β-decays in A = 17 mass region and the role of proton halo in 17F

    International Nuclear Information System (INIS)

    Michel, N.; Okolowicz, J.; Ploszajczak, M.; Okolowicz, J.; Nowacki, F.; Ploszajczak, M.


    The first-forbidden β-decay of 17 Ne into the 'halo' state J π 1/2 + 1 of 17 F presents one of the largest measured asymmetries for mirror β-decay feeding bound final states. This asymmetry is studied in the framework of the Shell Model Embedded in the Continuum (SMEC). The spatial extent of single particle orbits calculated in SMEC is constrained by the proton capture cross-section 16 O(p,γ) 17 F. This allows to estimate the mirror symmetry breaking in 17 F and 17 O nuclei. (authors)

  2. 12 CFR 16.8 - Small issues. (United States)


    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Small issues. 16.8 Section 16.8 Banks and....8 Small issues. (a) The OCC will deem offers and sales of bank issued securities that satisfy the requirements of Commission Regulation A (17 CFR part 230, Regulation A—Conditional Small Issues Exemption) to...

  3. 24 Annual meeting of the Spanish Nuclear Society, Valladolid 14-16 October 1998

    International Nuclear Information System (INIS)


    The technical sessions of XXIV annual meeting of the Spanish Nuclear Society were: 1) Fusion 2) Engineering: calculation and simulation. 3) Economical, legal and social aspect. 4) Plant life extension 5) Operating experiences, refueling and operation support 6) Probabilistic safety 7) Radiological protection 8) Waste management 9)Maintenance 10) Nuclear Safety R and D. 11)Environmental aspects 12) Fuel 13) Quality

  4. Neuroticism and extraversion in relation to physiological stress reactivity during adolescence

    NARCIS (Netherlands)

    Evans, Brittany E.; Stam, Jacqueline; Huizink, Anja C.; Willemen, Agnes M.; Westenberg, P. Michiel; Branje, Susan; Meeus, W.H.J.; Koot, Hans M.; van Lier, Pol A. C.


    The current study examined mean level and change in extraversion and neuroticism across adolescence in relation to physiological stress reactivity to social evaluation. Adolescents (n=327) from the Dutch general population reported on personality measures at five annual assessments. At age 17 years,

  5. Students' motivation toward laboratory work in physiology teaching. (United States)

    Dohn, Niels Bonderup; Fago, Angela; Overgaard, Johannes; Madsen, Peter Teglberg; Malte, Hans


    The laboratory has been given a central role in physiology education, and teachers report that it is motivating for students to undertake experimental work on live animals or measuring physiological responses on the students themselves. Since motivation is a critical variable for academic learning and achievement, then we must concern ourselves with questions that examine how students engage in laboratory work and persist at such activities. The purpose of the present study was to investigate how laboratory work influences student motivation in physiology. We administered the Lab Motivation Scale to assess our students' levels of interest, willingness to engage (effort), and confidence in understanding (self-efficacy). We also asked students about the role of laboratory work for their own learning and their experience in the physiology laboratory. Our results documented high levels of interest, effort, and self-efficacy among the students. Correlation analyses were performed on the three motivation scales and exam results, yet a significant correlation was only found between self-efficacy in laboratory work and academic performance at the final exam. However, almost all students reported that laboratory work was very important for learning difficult concepts and physiological processes (e.g., action potential), as the hands-on experiences gave a more concrete idea of the learning content and made the content easier to remember. These results have implications for classroom practice as biology students find laboratory exercises highly motivating, despite their different personal interests and subject preferences. This highlights the importance of not replacing laboratory work by other nonpractical approaches, for example, video demonstrations or computer simulations. Copyright © 2016 The American Physiological Society.

  6. Colon cancer mimicking physiologic FDG uptake: with using of negative oral contrast

    International Nuclear Information System (INIS)

    Jeong, Young Jin; Kang, Do Young


    A 64-year-old female with glioblastoma multiforme (GBM) was assigned to our department for whole body PET/CT scan. She ingested 1 liter of pure water as negative oral contrast just before PET/CT examination. FDG-PET/CT images showed a very intense hypermetabolic, focal lesion in the abdominal cavity around descending colon. The SUVmax of the lesion was 17.2. But there was no abnormal lesion corresponded to the area of PET scan in the combined contrast enhanced CT scan. We suggested considering a malignant lesion due to very intense glycolytic activity. Conventional abdominal CT scan and colonoscopy were accomplished within one week after PET/CT evaluation. There was no abnormality in both examinations. We executed follow-up PET/CT evaluation after 1 month and couldn't find any abnormality around the corresponding area. So we concluded the hypermetabolism was colonic physiologic uptake. A colonic physiologic uptake is a well known cause of false positive finding. Nuclear physicians should be considered the possibility of malignancy when interpret focal colonic uptake, especially incidental finding. 1-3) There are a few reports that using of negative oral contrast is able to reduce gastrointestinal physiologic uptakes. 4,5) But as we can see in this case, although we used negative oral contrast, intense physiologic uptake is detected and maxSUV is able to up to 17.2. So, it is important to keep a fact in mind. Even though there is a colonic physiologic uptake in PET/CT image, it may be able to show very intense hypermetabolism regardless of using negative oral contrast

  7. Bacterial diversity in Adélie penguin, Pygoscelis adeliae, guano: molecular and morpho-physiological approaches. (United States)

    Zdanowski, Marek K; Weglenski, Piotr; Golik, Pawel; Sasin, Joanna M; Borsuk, Piotr; Zmuda, Magdalena J; Stankovic, Anna


    The total number of bacteria and culturable bacteria in Adélie penguin (Pygoscelis adeliae) guano was determined during 42 days of decomposition in a location adjacent to the rookery in Admiralty Bay, King George Island, Antarctica. Of the culturable bacteria, 72 randomly selected colonies were described using 49 morpho-physiological tests, 27 of which were subsequently considered significant in characterizing and differentiating the isolates. On the basis of the nucleotide sequence of a fragment of the 16S rRNA gene in each of 72 pure isolates, three major phylogenetic groups were identified, namely the Moraxellaceae/Pseudomonadaceae (29 isolates), the Flavobacteriaceae (14), and the Micrococcaceae (29). Grouping of the isolates on the basis of morpho-physiological tests (whether 49 or 27 parameters) showed similar results to those based on 16S rRNA gene sequences. Clusters were characterized by considerable intra-cluster variation in both 16S rRNA gene sequences and morpho-physiological responses. High diversity in abundance and morphometry of total bacterial communities during penguin guano decomposition was supported by image analysis of epifluorescence micrographs. The results indicate that the bacterial community in penguin guano is not only one of the richest in Antarctica, but is extremely diverse, both phylogenetically and morpho-physiologically.

  8. Gallbladder Agenesis in 17 Dogs: 2006-2016. (United States)

    Sato, K; Sakai, M; Hayakawa, S; Sakamoto, Y; Kagawa, Y; Kutara, K; Teshima, K; Asano, K; Watari, T


    Gallbladder agenesis (GBA) is extremely rare in dogs. To describe the history, clinical signs, diagnosis, treatment, and outcomes of dogs with GBA. Seventeen client-owned dogs with GBA. Medical records from 2006 through 2016 were retrospectively reviewed. Dogs were included when GBA was suspected on abdominal ultrasonography and confirmed by gross evaluation. Signalment, clinical signs, clinicopathological data, diagnostic imaging, histopathology, treatment, and outcome were recorded. Dogs were of 6 different breeds, and Chihuahuas (10 of 17) were most common. Median age at presentation was 1.9 (range, 0.7-7.4) years. Clinical signs included vomiting (5 of 17), anorexia (2 of 17), ascites (2 of 17), diarrhea (1 of 17), lethargy (1 of 17), and seizures (1 of 17). All dogs had increased serum activity of at least 1 liver enzyme, most commonly alanine aminotransferase (15 of 17). Fifteen dogs underwent computed tomography (CT) cholangiography; common bile duct (CBD) dilatation was confirmed in 12, without evidence of bile duct obstruction. Gross evaluation confirmed malformation of the liver lobes in 14 of 17 dogs and acquired portosystemic collaterals in 5 of 17. Ductal plate malformation was confirmed histologically in 16 of 17 dogs. During follow-up (range, 4-3,379 days), 16 of 17 dogs remained alive. Dogs with GBA exhibit clinicopathological signs of hepatobiliary injury and hepatic histopathological changes consistent with a ductal plate abnormality. Computed tomography cholangiography was superior to ultrasound examination in identifying accompanying nonobstructive CBD distention. Computed tomography cholangiography combined with laparoscopic liver biopsy is the preferable approach to characterize the full disease spectrum accompanying GBA in dogs. Copyright © 2018 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

  9. Literacy Education and Sustainable Development in Developing Societies (United States)

    Oghenekohwo, Jonathan E.; Frank-Oputu, Ekima A.


    The development of a literate society is a pre-requisite for the emergence of a knowledge economy. The thesis advanced in this paper is that, without massive investment and promotion of literacy education, development that is targeted at the 17-point sustainable development goals (SDGs) will be bereft of citizen's empowerment, engagement,…

  10. Physiomodel - an integrative physiology in Modelica. (United States)

    Matejak, Marek; Kofranek, Jiri


    Physiomodel ( is our reimplementation and extension of an integrative physiological model called HumMod 1.6 ( using our Physiolibrary ( The computer language Modelica is well-suited to exactly formalize integrative physiology. Modelica is an equation-based, and object-oriented language for hybrid ordinary differential equations (http:// Almost every physiological term can be defined as a class in this language and can be instantiated as many times as it occurs in the body. Each class has a graphical icon for use in diagrams. These diagrams are self-describing; the Modelica code generated from them is the full representation of the underlying mathematical model. Special Modelica constructs of physical connectors from Physiolibrary allow us to create diagrams that are analogies of electrical circuits with Kirchhoff's laws. As electric currents and electric potentials are connected in electrical domain, so are molar flows and concentrations in the chemical domain; volumetric flows and pressures in the hydraulic domain; flows of heat energy and temperatures in the thermal domain; and changes and amounts of members in the population domain.

  11. Physiological indicators of pathologic video game use in adolescence. (United States)

    Coyne, Sarah M; Dyer, W Justin; Densley, Rebecca; Money, Nathan M; Day, Randal D; Harper, James M


    Pathologic video game use (PVGU) has been associated with a host of negative psychological, physical, and social outcomes during adolescence; however, little research has examined physiological predictors of such use. The purpose of the study was to examine physiological predictors of the development of PVGU across adolescence. The article involves a 1-year longitudinal study across midadolescence. Participants were 374 adolescents and their parents from a large metropolitan area in the Northwest United States. PVGU was assessed via questionnaire, as were a number of control variables. A number of physiological indicators including respiratory sinus arrhythmia (RSA) and galvanic skin conductance (indices of parasympathetic and sympathetic nervous system activity, respectively) were measured during baseline, a cognitively stimulating task (Rubik's cube), and a family problem-solving task. Less RSA withdrawal to a cognitively simulating task was related to greater pathologic video game symptoms, but less RSA withdrawal to a family problem-solving task was associated with the presence of pathologic video game symptoms (p video game symptoms (p < .01). These findings suggest that adolescents who do not find cognitive tasks stimulating physiologically have a greater severity of PVGU. Additionally, adolescents who show physiological signs of stress in a family task were more likely to have PVGU symptoms and only girls have more severe PVGU levels. This study is the first to show that physiological indicators predict PVGU over time in adolescence and has important implications regarding the prevention and treatment of PVGU in adolescence. Copyright © 2015 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

  12. Thermal stability of chicken brain {alpha}-spectrin repeat 17: a spectroscopic study

    Energy Technology Data Exchange (ETDEWEB)

    Brenner, Annette K. [University of Bergen, Department of Chemistry (Norway); Kieffer, Bruno [Ecole Superieure de Biotechnologie de Strasbourg, IGBMC Biomolecular NMR Group, CNRS UMR 7104 (France); Trave, Gilles [Ecole Superieure de Biotechnologie de Strasbourg, Equipe Oncoproteines, IREBS, UMR 7242 (France); Froystein, Nils Age [University of Bergen, Department of Chemistry (Norway); Raae, Arnt J., E-mail: [University of Bergen, Department of Molecular Biology (Norway)


    Spectrin is a rod-like multi-modular protein that is mainly composed of triple-helical repeats. These repeats show very similar 3D-structures but variable conformational and thermodynamical stabilities, which may be of great importance for the flexibility and dynamic behaviour of spectrin in the cell. For instance, repeat 17 (R17) of the chicken brain spectrin {alpha}-chain is four times less stable than neighbouring repeat 16 (R16) in terms of Increment G. The structure of spectrin repeats has mainly been investigated by X-ray crystallography, but the structures of a few repeats, e.g. R16, have also been determined by NMR spectroscopy. Here, we undertook a detailed characterization of the neighbouring R17 by NMR spectroscopy. We assigned most backbone resonances and observed NOE restraints, relaxation values and coupling constants that all indicated that the fold of R17 is highly similar to that of R16, in agreement with previous X-ray analysis of a tandem repeat of the two domains. However, {sup 15}N heteronuclear NMR spectra measured at different temperatures revealed particular features of the R17 domain that might contribute to its lower stability. Conformational exchange appeared to alter the linker connecting R17 to R16 as well as the BC-loop in close proximity. In addition, heat-induced splitting was observed for backbone resonances of a few spatially related residues including V99 of helix C, which in R16 is replaced by the larger hydrophobic tryptophan residue that is relatively conserved among other spectrin repeats. These data support the view that the substitution of tryptophan by valine at this position may contribute to the lower stability of R17.

  13. Physiological adaptation to recurrent social stress of extraversion. (United States)

    Lu, Wei; Wang, Zhenhong


    The present studies examined the influence of extraversion on physiological reactivity, recovery, and physiological habituation-sensitization to repeated social stressors. In Study 1, subjective and physiological data were collected from 97 college students who were categorized as high (n = 51) and low (n = 46) on extraversion (NEO-FFI) across five laboratory stages: baseline, stress 1, poststress 1, stress 2, and poststress 2. Results indicated high extraversion (HE) participants exhibited relative lesser heart rate (HR) reactivity and respiratory sinus arrhythmia (RSA) withdrawals to, and more complete HR and RSA recovery after the first social stress, and also exhibited relative lesser HR reactivity to the second social stress. When repeatedly exposed to a social stressor, HE participants showed pronounced systolic blood pressure (SBP) adaptation, low extraversion (LE) participants displayed diastolic blood pressure (DBP) sensitization. In Study 2, data were collected from another 78 participants (HE: n = 40, LE: n = 38) across the same laboratory stages with speech performance videotaped. After controlling for the speech styles, Study 2 found the same HR response and SBP/DBP adaptation pattern across extraversion groups to social stress as Study 1 but not RSA reactivity. These findings suggest extraverts exhibit more adaptive physiological reactivity to recurrent social stressors, which thus might benefit their health. © 2016 Society for Psychophysiological Research.

  14. Perspectives of Physiology as a Discipline from Senior-Level Millennial-Generation Students (United States)

    Steury, Michael D.; Poteracki, James M.; Kelly, Kevin L.; Wehrwein, Erica A.


    In the last several decades, there has been a shift in the mindset of research structure from classical "systems or integrative biology" to more molecular focused "-omics" study. A recent topic of debate in physiological societies has been whether or not the "-omic" revolution has delivered in its promises in both…

  15. Starting physiology: bioelectrogenesis. (United States)

    Baptista, Vander


    From a Cartesian perspective of rational analysis, the electric potential difference across the cell membrane is one of the fundamental concepts for the study of physiology. Unfortunately, undergraduate students often struggle to understand the genesis of this energy gradient, which makes the teaching activity a hard task for the instructor. The topic of bioelectrogenesis encompasses multidisciplinary concepts, involves several mechanisms, and is a dynamic process, i.e., it never turns off during the lifetime of the cell. Therefore, to improve the transmission and acquisition of knowledge in this field, I present an alternative didactic model. The design of the model assumes that it is possible to build, in a series of sequential steps, an assembly of proteins within the membrane of an isolated cell in a simulated electrophysiology experiment. Initially, no proteins are inserted in the membrane and the cell is at a baseline energy state; the extracellular and intracellular fluids are at thermodynamic equilibrium. Students are guided through a sequence of four steps that add key membrane transport proteins to the model cell. The model is simple at the start and becomes progressively more complex, finally producing transmembrane chemical and electrical gradients. I believe that this didactic approach helps instructors with a more efficient tool for the teaching of the mechanisms of resting membrane potential while helping students avoid common difficulties that may be encountered when learning this topic. Copyright © 2015 The American Physiological Society.

  16. Giant magnetic entropy change in manganese perovskite La{sub 0.67}Sr{sub 0.16}Ca{sub 0.17}MnO{sub 3} near room temperature

    Energy Technology Data Exchange (ETDEWEB)

    Mohamed, Za, E-mail: [Laboratoire de Physique de la matière condensée et des nanosciences, Faculté des Sciences, 5019, Université de Monastir (Tunisia); Tka, E.; Dhahri, J. [Laboratoire de Physique de la matière condensée et des nanosciences, Faculté des Sciences, 5019, Université de Monastir (Tunisia); Hlil, E.K. [Institut Néel, CNRS et Université Joseph Fourrier, B.P. 166, B.P.W-38042 Grenoble Cedex 9 (France)


    Highlights: • La{sub 0.67}Sr{sub 0.16}Ca{sub 0.17}MnO{sub 3} sample was prepared by solid state method. • La{sub 0.67}Sr{sub 0.16}Ca{sub 0.17}MnO{sub 3} crystallizes in a rhombohedral R3{sup ‾}c structure. • The variation of (M) vs. (T) reveals a (FM) to (PM) phase transition around T{sub C}. • The magnetocaloric effect is studied and the |ΔS{sub M}{sup max}| and RCP are determined. - Abstract: Structural, magnetic and magnetocaloric properties of La{sub 0.67}Sr{sub 0.16}Ca{sub 0.17}MnO{sub 3} perovskite have been studied. A solid state reaction method was used in the preparation phase. X-ray diffraction analysis using Rietveld refinement revealed that this sample crystallizes in the distorted rhombohedral system with R3{sup ‾}c space group. The variation of magnetization (M) vs. temperature (T), under an applied magnetic field of 0.05T, revealed a transition from a ferromagnetic (FM) to paramagnetic (PM) phase at around Curie temperature (T{sub C} = 336 K). Using Arrott plots, it was found that the transition is of a second-order. Isothermal measurements of magnetization allow us, through thermodynamic Maxwell relations, to determine the magnetic entropy change (ΔS{sub M}). A large ΔS{sub M} deduced from isothermal magnetization curves, has been observed in our sample with a peak centered around its respective T{sub C}. The maximum of the magnetic entropy change ΔS{sub M}{sup max} in a magnetic field change of 5T is found to be 5.51 J kg{sup −1} K{sup −1} at 335 K. In addition, the compound showed a large relative cooling power (RCP) value of about 234 J/kg while the maximum refrigerant capacity of 174 J/kg was attained at the applied field of 5T. As a result, the studied sample can be considered as a potential material for magnetic refrigeration.

  17. 50 CFR 14.16 - Border ports. (United States)


    ..., TRANSPORTATION, SALE, PURCHASE, BARTER, EXPORTATION, AND IMPORTATION OF WILDLIFE AND PLANTS IMPORTATION...) Texas—Brownsville, El Paso, Laredo. (c) Except for wildlife requiring a permit pursuant to part 16, 17...

  18. Approaches to modeling the development of physiological stress responsivity. (United States)

    Hinnant, J Benjamin; Philbrook, Lauren E; Erath, Stephen A; El-Sheikh, Mona


    Influential biopsychosocial theories have proposed that some developmental periods in the lifespan are potential pivot points or opportunities for recalibration of stress response systems. To date, however, there have been few longitudinal studies of physiological stress responsivity and no studies comparing change in physiological stress responsivity across developmental periods. Our goals were to (a) address conceptual and methodological issues in studying the development of physiological stress responsivity within and between individuals, and (b) provide an exemplar for evaluating development of responsivity to stress in the parasympathetic nervous system, comparing respiratory sinus arrhythmia (RSA) responsivity from middle to late childhood with middle to late adolescence. We propose the use of latent growth modeling of stress responsivity that includes time-varying covariates to account for conceptual and methodological issues in the measurement of physiological stress responsivity. Such models allow researchers to address key aspects of developmental sensitivity including within-individual variability, mean level change over time, and between-individual variability over time. In an empirical example, we found significant between-individual variability over time in RSA responsivity to stress during middle to late childhood but not during middle to late adolescence, suggesting that childhood may be a period of greater developmental sensitivity at the between-individual level. © 2017 Society for Psychophysiological Research.

  19. Neurosurgery certification in member societies of the World Federation of Neurosurgical Societies: Asia. (United States)

    Gasco, Jaime; Braun, Jonathan D; McCutcheon, Ian E; Black, Peter M


    To objectively compare the complexity and diversity of the certification process in neurological surgery in member societies of the World Federation of Neurosurgical Societies. This study centers in continental Asia. We provide here an analysis based on the responses provided to a 13-item survey. The data received were analyzed, and three Regional Complexity Scores (RCS) were designed. To compare national board experience, eligibility requirements for access to the certification process, and the obligatory nature of the examinations, an RCS-Organizational score was created (20 points maximum). To analyze the complexity of the examination, an RCS-Components score was designed (20 points maximum). The sum of both is presented in a Global RCS score. Only those countries that responded to the survey and presented nationwide homogeneity in the conduction of neurosurgery examinations could be included within the scoring system. In addition, a descriptive summary of the certification process per responding society is also provided. On the basis of the data provided by our RCS system, the highest global RCS was achieved by South Korea and Malaysia (21/40 points) followed by the joint examination of Singapore and Hong-Kong (FRCS-Ed) (20/40 points), Japan (17/40 points), the Philippines (15/40 points), and Taiwan (13 points). The experience from these leading countries should be of value to all countries within Asia. Copyright © 2011 Elsevier Inc. All rights reserved.

  20. Adding Value to a Graduate Physiology Seminar by Focusing on Public Communication Skills (United States)

    LaRocca, Thomas J.; Justice, Jamie N.; Seals, Douglas R.; Martens, Christopher R.


    A major goal of graduate education is the development of students as "stewards of the discipline," scholars who can create and preserve knowledge and responsibly translate it through writing, teaching, and practical applications. These qualities are consistent with the American Physiological Society's list of professional skills for…

  1. Dissipation of 17β-estradiol in composted poultry litter. (United States)

    Hakk, Heldur; Sikora, Lawrence


    The excreted estrogen rate of all livestock in the United States is estimated at 134 kg d. The influence of manure treatment on the fate of estrogens is critical in deciding the recycling of over 300 million dry tons of livestock produced annually. The effects of two common manure management practices, heated composting and ambient temperature decomposition, on the fate of 17β-estradiol in poultry litter were determined. A mixture of poultry litter, wood chips, and straw was amended with [C]17β-estradiol and allowed to undergo decomposition with a laboratory-scale heated composter (HC) or room temperature incubation (RTI) for 24 d. Radiolabel in the finished products was fractionated into water-extractable, acetone-extractable, nonextractable, and mineralized fractions. Total 17β-estradiol radioactive residues in the HC and RTI ( = 2) treatments were not different ( > 0.05), except that statistically less 17β-estradiol was mineralized to CO during HC than RTI (1.1 vs. 10.0% for HC and RTI, respectively). Estrone was the major degradation product in extracts of HC and RTI treatments as determined by liquid chromatography/mass spectrometry analyses. The nonextractable residues indicated no quantitative differences among the humins between the treatments. An estimated 3% of the fortified estrogenicity remained after HC treatment, and 15% of the fortified estrogenicity remained after RTI treatment. If reduction of water-removable, biologically active 17β-estradiol is the treatment goal, then HC treatment would be slightly preferred over ambient temperature degradation. However, unmanaged, ambient temperature litter piles are less costly and time consuming for food animal producers and result in greater mineralization and similar immobilization of estradiol. by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, Inc.

  2. 17Beta-hydroxysteroid dehydrogenase (17beta-HSD) in scleractinian corals and zooxanthellae. (United States)

    Blomquist, Charles H; Lima, P H; Tarrant, A M; Atkinson, M J; Atkinson, S


    Steroid metabolism studies have yielded evidence of 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activity in corals. This project was undertaken to clarify whether there are multiple isoforms of 17beta-HSD, whether activity levels vary seasonally, and if zooxanthellae contribute to activity. 17Beta-HSD activity was characterized in zooxanthellate and azooxanthellate coral fragments collected in summer and winter and in zooxanthellae cultured from Montipora capitata. More specifically, 17beta-HSD activity was characterized with regard to steroid substrate and inhibitor specificity, coenzyme specificity, and Michaelis constants for estradiol (E2) and NADP+. Six samples each of M. capitata and Tubastrea coccinea (three summers, three winters) were assayed with E2 and NADP+. Specific activity levels (pmol/mg protein) varied 10-fold among M. capitata samples and 6-fold among T. coccinea samples. There was overlap of activity levels between summer and winter samples. NADP+/NAD+ activity ratios varied from 1.6 to 22.2 for M. capatita, 2.3 to 3.8 for T. coccinea and 0.7 to 1.1 for zooxanthellae. Coumestrol was the most inhibitory of the steroids and phytoestrogens tested. Our data confirm that corals and zooxanthellae contain 17beta-HSD and are consistent with the presence of more than one isoform of the enzyme.

  3. 31 CFR 1.7 - Fees for services. (United States)


    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Fees for services. 1.7 Section 1.7 Money and Finance: Treasury Office of the Secretary of the Treasury DISCLOSURE OF RECORDS Freedom of... Department shall charge for search time at the salary rate(s) (basic pay plus 16 percent) of the employee(s...

  4. Use of an iPad App to simulate pressure-volume loops and cardiovascular physiology. (United States)

    Leisman, Staci; Burkhoff, Daniel


    The purpose of this laboratory exercise is to model the changes in preload, afterload, and contractility on a simulated pressure-volume loop and to correlate those findings with common measurements of clinical cardiovascular physiology. Once students have modeled these changes on a healthy heart, the students are asked to look at a simulated case of cardiogenic shock. Effects on preload, contractility, and afterload are explored, as well as the hemodynamic effects of a number of student-suggested treatment strategies. Copyright © 2017 the American Physiological Society.

  5. Gene : CBRC-PTRO-17-0015 [SEVENS

    Lifescience Database Archive (English)


  6. Using whiteboards to support college students' learning of complex physiological concepts. (United States)

    Inouye, Caron Y; Bae, Christine L; Hayes, Kathryn N


    Research underscores the importance of retrieval-based practice and application of knowledge for meaningful learning. However, the didactic lecture format continues to persist in traditional university physiology courses. A strategy called whiteboarding, where students use handheld dry erase boards and work in small groups to actively retrieve, discuss, and apply concepts presented in the lecture, has the potential to address challenges associated with actively engaging students in science courses for greater learning. The purpose of this study was to empirically examine the potential benefits of whiteboarding for increasing students' understanding of animal physiology concepts. Student performance on physiology questions assessing concepts taught using lecture only vs. concepts taught using lecture and whiteboarding were compared within the term that whiteboarding was used, as well as across whiteboard and lecture-only terms taught by the same instructor. Results showed that when whiteboarding was incorporated in the course, student performance on items that assessed concepts corresponding to the whiteboarding activities were significantly higher compared with performance on items that assessed concepts taught through lecture only. These patterns in student performance were found within and across terms. Taken together, findings point to whiteboarding as an effective tool that can be integrated in traditional lecture courses to promote students' understanding of physiology. Copyright © 2017 the American Physiological Society.



    Matković, Andro; Rupčić, Tomislav; Knjaz, Damir


    The objective of this study was to establish physiological loads elite basketball referees sustain during competitive games. Thirty-one referees (age: 33.35±5.17 years, body mass: 88.04±7.47 kg, height: 186.37±5.40 cm), all classified as A-list referees of the 1st Croatian Basketball League, were subjected to progressive spiroergometric testing on the treadmill in order to determine the anaerobic threshold (V-slope method). The referees were monitored electrocardiographically for the estab...

  8. Pain: metaphor, body, and culture in Anglo-American societies between the eighteenth and twentieth centuries. (United States)

    Bourke, Joanna


    This article explores the relationship between metaphorical languages, body, and culture, and suggests that such an analysis can reveal a great deal about the meaning and experience of pain in Anglo-American societies between the eighteenth and twentieth centuries. It uses concepts within embodied cognition to speculate on how historians can write a history of sensation. Bodies are actively engaged in the linguistic processes and social interactions that constitute painful sensations. Language is engaged in a dialogue with physiological bodies and social environments. And culture collaborates in the creation of physiological bodies and metaphorical systems.

  9. The ins and outs of breath holding: simple demonstrations of complex respiratory physiology. (United States)

    Skow, Rachel J; Day, Trevor A; Fuller, Jonathan E; Bruce, Christina D; Steinback, Craig D


    The physiology of breath holding is complex, and voluntary breath-hold duration is affected by many factors, including practice, psychology, respiratory chemoreflexes, and lung stretch. In this activity, we outline a number of simple laboratory activities or classroom demonstrations that illustrate the complexity of the integrative physiology behind breath-hold duration. These activities require minimal equipment and are easily adapted to small-group demonstrations or a larger-group inquiry format where students can design a protocol and collect and analyze data from their classmates. Specifically, breath-hold duration is measured during a number of maneuvers, including after end expiration, end inspiration, voluntary prior hyperventilation, and inspired hyperoxia. Further activities illustrate the potential contribution of chemoreflexes through rebreathing and repeated rebreathing after a maximum breath hold. The outcome measures resulting from each intervention are easily visualized and plotted and can comprise a comprehensive data set to illustrate and discuss complex and integrated cardiorespiratory physiology. Copyright © 2015 The American Physiological Society.

  10. Direct Fermi-surface image of hidden nesting for NaMo6O17 and KMo6O17

    International Nuclear Information System (INIS)

    Gweon, G.-.; Allen, J.W.; Clack, J.A.; Zhang, Y.X.; Poirier, D.M.; Benning, P.J.; Olson, C.G.; Marcus, J.; Schlenker, C.


    We report direct Fermi-surface images obtained with angle-resolved photoemission spectroscopy (ARPES) for NaMo 6 O 17 and KMo 6 O 17 above the charge-density wave transition temperatures. We also report ARPES spectra of the valence band of NaMo 6 O 17 . The images imply a Fermi surface (FS) based on three underlying quasi-one-dimensional (quasi-1D) surfaces. Thus it agrees in detail with that expected in the hidden nesting picture of Whangbo et al. [Science 252, 96 (1991)], but differs greatly from a FS deduced in a previous study by Breuer et al. [Phys. Rev. Lett. 76, 3172 (1996)], which found only two underlying quasi-1D surfaces. copyright 1997 The American Physical Society

  11. Solvent hold tank sample results for MCU-17-122-124 (March 2017), MCU-17-130-132 (April 2017), MCU-17-133-135 (May 2017), and MCU-17-141-149 (June 2017): Quarterly Report

    Energy Technology Data Exchange (ETDEWEB)

    Fondeur, F. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Jones, D. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)


    A trend summary of four Solvent Hold Tank (SHT) monthly samples; MCU-16-122-124 (March 2017), MCU-17-130-132 (April 2017), MCU-17-133-135 (May 2017), and MCU-17-141-149 (June 2017) are reported. Analyses of the June SHT sample (MCU-17-141-149) indicated that the modifier (CS-7SB) and the extractant (MaxCalix) concentrations were slightly below (4% each) their nominal recommended levels (169,000 mg/L and 46,400 mg/L respectively). The suppressor (TiDG) level has decreased since the January 2017 measurement but has remained steady in the range of 666 to 705 mg/L, well above the minimum recommended level (479 mg/L), but below the nominal level. The “flat” trends observed in the TiDG, MaxCalix, modifier, and Gamma measurement are consistent with the solvent being idle since January 10, 2017.

  12. Report on materials characterization center workshop on stress corrosion cracking for the Salt Repository Project, December 16-17, 1986, Seattle, Washington: Workshop summary

    International Nuclear Information System (INIS)

    Merz, M.D.; Shannon, D.W.


    The Materials Characterization Center (MCC) at Pacific Northwest Laboratory (PNL) conducted a Workshop on Stress Corrosion Cracking for the Salt Repository Project on December 16 and 17, 1986 in Seattle, Washington. The workshop was held to formulate recommendations for addressing stress corrosion cracking (SCC) in a salt repository. It was attended by 24 representatives from major laboratories, universities, and industry. This report presents the recommendations of the workshop, along with the agenda, list of participants, questions and comments, summaries of working groups on low-strength steel and alternate materials, and materials handed out by the speakers

  13. DNA commission of the International Society for Forensic Genetics

    DEFF Research Database (Denmark)

    Gill, P; Brenner, C H; Buckleton, J S


    The DNA commission of the International Society of Forensic Genetics (ISFG) was convened at the 21st congress of the International Society for Forensic Genetics held between 13 and 17 September in the Azores, Portugal. The purpose of the group was to agree on guidelines to encourage best practice...... a consensus from experts but to be practical we do not claim to have conveyed a clear vision in every respect in this difficult subject. For this reason, we propose to allow a period of time for feedback and reflection by the scientific community. Then the DNA commission will meet again to consider further...

  14. 40 CFR 74.17 - Application requirements for process sources. [Reserved (United States)


    ... requirements for process sources. [Reserved] ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Application requirements for process sources. [Reserved] 74.17 Section 74.17 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY...

  15. Biodistribution and breast tumor uptake of 16α-[18F]-fluoro-17β-estradiol in rat

    International Nuclear Information System (INIS)

    Sasaki, Masayuki; Fukumura, Toshimitsu; Kuwabara, Yasuo; Yoshida, Tsuyoshi; Nakagawa, Makoto; Ichiya, Yuichi; Masuda, Kouji


    To evaluate the usefulness of 16α-[ 18 F]-fluoro-17β-estradiol (FES) for the assessment of estrogen receptor (ER), we examined the tissue distribution and kinetics of FES in immature female Sprague-Dawley rats and then examined FES uptake in rat breast tumors induced by 7,12-dimethylbenz(a)anthracene (DMBA). The FES uptake by the uterus, an ER-rich tissue, was highly selective and it was 3.34±0.79%ID/g at 60 minutes and 1.57±0.57%ID/g at 120 minutes after injection. The FES uptakes in ER-negative tissues were 0.12±0.05%ID/g or less and 0.05±0.03%ID/g or less, respectively. Coadministration of unlabeled β-estradiol showed marked depression of uterine FES uptake. The FES uptake by rat breast tumors was 0.14±0.06%ID/g at 60 min and 0.12±0.09%ID/g at 120 min. The FES uptake by rat breast tumors correlated with the ER concentration (r=0.45, p<0.05). In conclusion, these results suggest that the FES uptake by tissue is mainly ER mediated and FES is thus useful for detecting ER positive breast tumors. (author)

  16. How do the Institutes on Teaching and Learning (ITLs) nurture the members of the Physiology Educators Community of Practice (PECOP)? (United States)

    Goodman, Barbara E


    Do you teach physiology? Do you use best practices when you teach physiology? Have you ever thought about conducting educational research? Do you need collaborators to help with ideas for educational research or to expand your research populations? The American Physiological Society (APS) Teaching Section has developed a biennial Institute on Teaching and Learning (ITL) through the APS Conference Program to address these issues. The first institute was held in June 2014, and the second institute was held in June 2016. A Physiology Education Community of Practice (PECOP) was created to help connect the institute participants and other physiology educators and to share evidence-based teaching in physiology at all education levels. The 2018 APS ITL will be the next meeting to learn best practices, to share ideas with colleagues, and to find collaborators in improving the teaching of physiology for students. The meeting will include workshops modeling best practices, plenary talks about hot new issues in physiology and science education, and poster sessions and informal meals to discuss interests with colleagues. Even if one's primary responsibility is bench research or administration, the training from the institute will improve efficiency and effectiveness when teaching. The two prior ITLs (2014 and 2016) were highly evaluated by educators of both undergraduate and professional students who spent a week together emphasizing improvement in their teaching. This paper reports the outcomes of the 2016 ITL and encourages participation in the upcoming ITL in Madison, WI, June 18-22, 2018. Watch the APS Conference site for more information about the 2018 ITL ( Copyright © 2017 the American Physiological Society.

  17. Validation of the Pangao PG-800B26 upper arm blood pressure monitor in the general population according to the European Society of Hypertension and the British Hypertension Society protocols. (United States)

    Chen, Liang; Li, Jiyu; Wen, Jing; Guo, Changfeng; Zhang, Jingying; Yu, Zhen


    This study aimed to evaluate the accuracy of the automated oscillometric upper arm blood pressure monitor Pangao PG-800B26 for home blood pressure monitoring according to the European Society of Hypertension International Protocol (ESH-IP) revision 2010 and the British Hypertension Society (BHS) protocols. Systolic and diastolic blood pressures were measured sequentially in 33 and 85 adults, respectively, on the basis of the ESH-IP and BHS protocols using a mercury sphygmomanometer (two observers) and the device (one supervisor). The procedures and analysis methods of the protocols were followed precisely. The device fulfilled the criteria of the ESH-IP, with device-observer differences of 1.01±5.16 and -0.58±4.17 mmHg for systolic and diastolic blood pressure, respectively. Furthermore, the A/A grade of the BHS protocol was also achieved for overall grading and for the three pressure levels, with average differences of 0.85±6.35 and -0.15±5.65 mmHg for systolic and diastolic blood pressure, respectively, which also fulfilled the requirements of the Association for the Advancement of Medical Instrumentation. The Pangao PG-800B26 fulfilled the criteria of the ESH-IP 2010 and achieved the A/A grade of the BHS protocol, and hence can be recommended for home use in adults.

  18. Salida de campo a la casa forestal ubicada en el pico Caimodorro (Orihuela del Tremedal, Teruel) el 16 y 17 de julio de 1952


    Valverde Gómez, José Antonio, 1926-2003


    Salida de campo del autor y Francisco Bernis a la casa forestal ubicada en el pico Caimodorro (Orihuela del Tremedal, Teruel), el 16 y 17 de julio de 1952, de la que se anotaron observaciones sobre lagartijas, los mamíferos Martes foina (Garduña) y Microtus sp. (Topillo), y las siguientes aves: Accipiter nisus (Gavilán común, también llamado Astur palumbarius por el autor), A.citrinella, Buteo buteo (Busardo ratonero, también llamado Águila ratera), Carduelis cannabina (Pardillo común, llamad...

  19. Melatonin as potential inducer of Th17 cell differentiation. (United States)

    Kuklina, Elena M


    The subset of T lymphocytes producing IL-17 (Th17) plays a key role in the immune system. It has been implicated in host defense, inflammatory diseases, tumorigenesis, autoimmune diseases, and transplant rejection. Careful analysis of the data available holds that Th17 cell subpopulation should be under the direct control of pineal hormone melatonin: the key Th17 differentiation factor RORα serves in the meantime as a high-affinity melatonin receptor. Since the levels of melatonin have diurnal and seasonal variation, as well as substantial deviations in some physiological or pathological conditions, melatonin-dependent regulation of Th17 cells should implicate multiform manifestation, such as influencing the outcome of infectious challenge or determining predisposition, etiology and progression of immune-related morbidities. Another important reason to raise a point of the new melatonin effects is current considering the possibilities of its clinical trials. Especially, the differentiation of Th17 upon melatonin treatment must aggravate the current recession in autoimmune diseases or induce serious complications in pregnancy. Copyright © 2014 Elsevier Ltd. All rights reserved.

  20. Past and present of adolescence in society: the 'teen brain' debate in perspective. (United States)

    Feixa, Carles


    Understood as the stage in individual life comprised between physiological puberty (a "natural" condition) and the recognition of the adult status (a "cultural" construction), adolescence has been envisaged as a universal condition, a stage in human development to be found in all societies and historical moments. Nevertheless, anthropological founding's across space and times depict a more complex panorama. The large variety of situations can be grouped into five big models of adolescence, which correspond to different types of society: "puber" from the primitive stateless societies; "ephebe" from ancient states; "boy and girl" from pre-industrial rural societies; "teenager" from the first industrialisation process and "youngsters" from modern post-industrial societies. In order to describe the features of these five models of youth, this article presents a series of ethnographical examples to illustrate the enormous plasticity of adolescence in past and present. This perspective is to be considered as the psycho-social and cultural environment for adolescent brain development, that will be discussed in depth along in this special issue. Copyright © 2011 Elsevier Ltd. All rights reserved.

  1. Geology of pre-Dakota uranium geochemical cell, sec. 13, T. 16 N., R. 17 W., Church Rock area, McKinley County

    International Nuclear Information System (INIS)

    Peterson, R.J.


    Exploration drilling on sec. 13, T. 16 N., R. 17 W., McKinley County, New Mexico, has defined uranium deposits within the Westwater Canyon Member of the Morrison Formation (Jurassic). Elongate, tabular, redistributed deposits were formed peripherally along the zones of highest transmissivity of the northeast-trending Westwater Canyon fluvial system by a Jurassic-Cretaceous geochemical cell. Strongly reducing conditions, which existed locally in the channel-margin areas owing to the presence of organic materials, were the primary ore control. Evidence that this major redistribution process took place in pre-Dakota time is the bleaching of the Westwater Canyon Sandstone by Dakota swamps is superimposed on older oxidation, and the primary mineralization above the Jurassic-Cretaceous water table was not affected by the geochemical-cell redistribution process

  2. Examination of uteroplacental blood flow with 113mIn (in physiological pregnancies)

    International Nuclear Information System (INIS)

    Ryznar, V.; Erban, J.; Pohanka, J.


    The total of 106 pregnant women in their 3rd trimester of physiological pregnancies were examined using 113m In and an LFOV Anger camera for the inflow rate of the applied radionuclide into the uteroplacental bed. The slope and T 1/2 were computed and the values valid for physiological pregnancies were defined. The authors' own method of normalization is used to process the obtained flow curves and all the data are assessed with the help of a PDP 11/34 on-line computer. In physiological pregnancies, T 1/2 and slope values for the 3rd trimester were found not to be influenced by the duration of the pregnancy or age of the pregnant woman. The discovered range of normal values for physiological pregnancies in their 3rd trimester are T 1/2 =8.3±1.7 s, slope more than 33. (author). 6 figs., 2 tabs., 34 refs

  3. Superposed epoch analysis of physiological fluctuations: possible space weather connections. (United States)

    Wanliss, James; Cornélissen, Germaine; Halberg, Franz; Brown, Denzel; Washington, Brien


    There is a strong connection between space weather and fluctuations in technological systems. Some studies also suggest a statistical connection between space weather and subsequent fluctuations in the physiology of living creatures. This connection, however, has remained controversial and difficult to demonstrate. Here we present support for a response of human physiology to forcing from the explosive onset of the largest of space weather events-space storms. We consider a case study with over 16 years of high temporal resolution measurements of human blood pressure (systolic, diastolic) and heart rate variability to search for associations with space weather. We find no statistically significant change in human blood pressure but a statistically significant drop in heart rate during the main phase of space storms. Our empirical findings shed light on how human physiology may respond to exogenous space weather forcing.

  4. Superposed epoch analysis of physiological fluctuations: possible space weather connections (United States)

    Wanliss, James; Cornélissen, Germaine; Halberg, Franz; Brown, Denzel; Washington, Brien


    There is a strong connection between space weather and fluctuations in technological systems. Some studies also suggest a statistical connection between space weather and subsequent fluctuations in the physiology of living creatures. This connection, however, has remained controversial and difficult to demonstrate. Here we present support for a response of human physiology to forcing from the explosive onset of the largest of space weather events—space storms. We consider a case study with over 16 years of high temporal resolution measurements of human blood pressure (systolic, diastolic) and heart rate variability to search for associations with space weather. We find no statistically significant change in human blood pressure but a statistically significant drop in heart rate during the main phase of space storms. Our empirical findings shed light on how human physiology may respond to exogenous space weather forcing.

  5. Nasal Physiology (United States)

    ... Caregivers Contact ARS HOME ANATOMY Nasal Anatomy Sinus Anatomy Nasal Physiology Nasal Endoscopy Skull Base Anatomy Virtual Anatomy Disclosure ... Patient Education About this Website Font Size + - Home > ANATOMY > Nasal Physiology Nasal Anatomy Sinus Anatomy Nasal Physiology Nasal Endoscopy ...

  6. The N=16 subshell closure; La fermeture de sous-couche N=16

    Energy Technology Data Exchange (ETDEWEB)

    Obertelli, A


    The sequence of magic numbers for stable nuclei is now well understood. However the magnitude of shell gap may evolve from stability to drip line. Several observables show that N = 16 neutron-rich isotones present a higher stability compared to their neighbors on the N-Z chart. The spectroscopy of the levels of Ne{sup 27}, involving sd and fp shells, has allowed us to study the evolution of the nuclear shells responsible for the structure changes in N 16 isotones. In this framework we have studied the neutron transfer reaction Ne{sup 26}(d,p)Ne{sup 27} by inverted kinematics at 9,7 MeV/u. A cryogenic D{sub 2} target (17{sup -2}) has been used. The use of the magnetic spectrometer Vamos and that of the Exogam photon detector in coincidence operating mode has allowed us to achieve the spectroscopy of Ne{sup 27}. The results show a reduction in the gap between sd and fp shells for N = 17 isotones as we go from stability toward the neutron drip line. We have also performed a theoretical study in mean-field theory and beyond it through configuration mixing so that we can see the evolution of the isospin of the N = 16 subshell's closure. We have used a HFB (Hartree-Fock-Bogoliubov) with the finite range D1S effective interaction. (A.C.)

  7. 38 Annual Meeting of Spanish Nuclear Society, Oct 17-19, 2012, Caceres, Spain

    International Nuclear Information System (INIS)


    -The Spanish Nuclear Society (SNE) is a non-profit association, made up of professionals and institutions in order to promote awareness and dissemination of science and nuclear technology. The 38th meeting of the SNE held in Caceres, analyzes the current situation of nuclear energy and its future challenges, covering different topics from engineering to R and D, nuclear safety, also the impact on health and the environment in the vicinity of a nuclear facility, the experience of Spanish companies in the construction of power and knowledge management in the nuclear sector.

  8. Characterization of high specific activity [16 alpha-123I]Iodo-17 beta-estradiol as an estrogen receptor-specific radioligand capable of imaging estrogen receptor-positive tumors

    International Nuclear Information System (INIS)

    Pavlik, E.J.; Nelson, K.; Gallion, H.H.; van Nagell, J.R. Jr.; Donaldson, E.S.; Shih, W.J.; Spicer, J.A.; Preston, D.F.; Baranczuk, R.J.; Kenady, D.E.


    16 alpha-[123I]Iodo-17 beta-estradiol (16 alpha-[123I]E2) has been characterized for use as a selective radioligand for estrogen receptor (ERc) that is capable of generating in situ images of ERc-positive tumors. High specific activity 16 alpha-[123I]E2 (7,500-10,000 Ci/mmol) was used in all determinations. Radiochemical purity was determined by thin layer chromatography, and the selectivity of radioligand for ERc was evaluated using size exclusion high performance liquid chromatography on ERc prepared from rodent uteri. Efficiencies of radioidination approaching 100% were achieved, and excellent receptor selectivity was obtained even when the efficiency of radioiodination was as low as 10%. Low radiochemical purity was always associated with poor selectivity for ERc. No new radioligand species was generated during the course of radiodecay; however, reduced binding over time, even when increased activity was used to compensate for radiodecay, indicated that the formation of a radioinert competitor does occur. 16 alpha-[123I]E2 demonstrated stable, high affinity binding to ERc and was concentrated by ERc-positive tissues. After injecting 16 alpha-[123I]E2 in vivo, images of ERc-containing tissues were obtained, including rabbit reproductive tract and dimethylbenzanthracene-induced tumors. The demonstrations of ERc selectivity and image formation both indicate that 16 alpha-[123I]E2 should have promise as a useful new radiopharmaceutical for imaging ERc-positive cancers

  9. Using paper presentation breaks during didactic lectures improves learning of physiology in undergraduate students. (United States)

    Ghorbani, Ahmad; Ghazvini, Kiarash


    Many studies have emphasized the incorporation of active learning into classrooms to reinforce didactic lectures for physiology courses. This work aimed to determine if presenting classic papers during didactic lectures improves the learning of physiology among undergraduate students. Twenty-two students of health information technology were randomly divided into the following two groups: 1) didactic lecture only (control group) and 2) didactic lecture plus paper presentation breaks (DLPP group). In the control group, main topics of gastrointestinal and endocrine physiology were taught using only the didactic lecture technique. In the DLPP group, some topics were presented by the didactic lecture method (similar to the control group) and some topics were taught by the DLPP technique (first, concepts were covered briefly in a didactic format and then reinforced with presentation of a related classic paper). The combination of didactic lecture and paper breaks significantly improved learning so that students in the DLPP group showed higher scores on related topics compared with those in the control group (P physiology. Copyright © 2016 The American Physiological Society.

  10. Brazilian actions to promote physiology learning and teaching in secondary and high schools. (United States)

    Mello-Carpes, Pâmela B; Granjeiro, Érica Maria; Montrezor, Luís Henrique; Rocha, Maria José Alves


    Members of the Education Committee of the Brazilian Society of Physiology have developed multiple outreach models to improve the appreciation of science and physiology at the precollege level. The members of this committee act in concert with important Brazilian governmental strategies to promote training of undergraduate students in the teaching environment of secondary and high schools. One of these governmental strategies, the Programa Institucional de Bolsas de Iniciação à Docência, a Brazilian public policy of teaching enhancement implemented by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) since 2007, represents a well-articulated public policy that can promote the partnership between University and Schools (7). Furthermore, the Program "Novos Talentos" (New Talents)/CAPES/Ministry of Education is another government initiative to bring together university and high-level technical training with the reality of Brazilian schools. Linked to the New Talents Program, in partnership with the British Council/Newton Fund, CAPES recently promoted the visit of some university professors that coordinate New Talents projects to formal and informal educational science spaces in the United Kingdom (Science, Technology, Engineering, and Mathematics, Brazil-United Kingdom International Cooperation Program) to qualify the actions developed in this area in Brazil, and one of us had the opportunity to participate with this. Copyright © 2016 The American Physiological Society.

  11. The Physiological Foundations of the Wealth of Nations

    DEFF Research Database (Denmark)

    Dalgaard, Carl-Johan Lars; Strulik, Holger

    Evidence from economics, anthropology and biology testifies to a fundamental trade-off between the number of offspring (quantity) and amount of nutrition per child (quality). This leads to a theory of pre-industrial growth where body size as well as population size is endogenous. But when...... productive quality investments are undertaken the historical constancy of income per capita seems puzzling. Why didn't episodes of rising income instigate a virtuous circle of rising body size and productivity? To address this question we propose that societies are subject to a "physiological check...

  12. Activation of catalase activity by a peroxisome-localized small heat shock protein Hsp17.6CII. (United States)

    Li, Guannan; Li, Jing; Hao, Rong; Guo, Yan


    Plant catalases are important antioxidant enzymes and are indispensable for plant to cope with adverse environmental stresses. However, little is known how catalase activity is regulated especially at an organelle level. In this study, we identified that small heat shock protein Hsp17.6CII (AT5G12020) interacts with and activates catalases in the peroxisome of Arabidopsis thaliana. Although Hsp17.6CII is classified into the cytosol-located small heat shock protein subfamily, we found that Hsp17.6CII is located in the peroxisome. Moreover, Hsp17.6CII contains a novel non-canonical peroxisome targeting signal 1 (PTS1), QKL, 16 amino acids upstream from the C-terminus. The QKL signal peptide can partially locate GFP to peroxisome, and mutations in the tripeptide lead to the abolishment of this activity. In vitro catalase activity assay and holdase activity assay showed that Hsp17.6CII increases CAT2 activity and prevents it from thermal aggregation. These results indicate that Hsp17.6CII is a peroxisome-localized catalase chaperone. Overexpression of Hsp17.6CII conferred enhanced catalase activity and tolerance to abiotic stresses in Arabidopsis. Interestingly, overexpression of Hsp17.6CII in catalase-deficient mutants, nca1-3 and cat2 cat3, failed to rescue their stress-sensitive phenotypes and catalase activity, suggesting that Hsp17.6CII-mediated stress response is dependent on NCA1 and catalase activity. Overall, we identified a novel peroxisome-located catalase chaperone that is involved in plant abiotic stress resistance by activating catalase activity. Copyright © 2017 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Ltd. All rights reserved.

  13. Physiological and anthropometric characteristics of top-level youth cross-country cyclists. (United States)

    Fornasiero, Alessandro; Savoldelli, Aldo; Modena, Roberto; Boccia, Gennaro; Pellegrini, Barbara; Schena, Federico


    In the literature there is a lack of data about the development of top level athletes in cross-country mountain biking (XCO). The purpose of this study was to analyze anthropometric and physiological characteristics of some of the best XCO bikers aged between 13 and 16. The study involved 45 bikers (26 males and 19 females) belonging to a youth national team. The evaluations, consisting of anthropometric measures, incremental cycling tests (VO 2max , PPO, P@RCP), and 30 s Wingate Tests (PMax, PMean), were conducted over a lapse of 4 years. Our findings showed in bikers, already at young age, a specific athletic profile advantageous for XCO performance. At the age of 16, just before entering the junior category and competing at international level, male and female bikers showed physiological values normalized to the body mass comparable to those reported in literature for high level athletes (VO 2max >70 and >60 ml/kg/min, PPO >6.5 and >5.5 W/kg, respectively in males and females). The production of high power-to-weight ratios and high peaks of anaerobic power attests the presence of highly developed aerobic and anaerobic systems in young XCO cyclists reflecting the high physiological demand of this sport.

  14. 17AAG-induced internalisation of HER2-specific Affibody molecules. (United States)

    Göstring, Lovisa; Lindegren, Sture; Gedda, Lars


    The geldanamycin derivative 17-allylamino-17-demethoxygeldanamycin (17-AAG) is known to induce internalisation and degradation of the otherwise internalisation-resistant human epidermal growth factor receptor 2 (HER2) receptor. In the present study, 17-AAG was used to increase internalisation of the HER2-specific Affibody molecule ABY-025. The cellular redistribution of halogen-labelled 211 At-ABY-025 and radiometal-labelled 111 In-ABY-025 following treatment with 17-AAG was studied. 17-AAG treatment of SKOV-3 human ovarian carcinoma and SKBR-3 human breast carcinoma cells to some extent shifted the localisation of 111 In-ABY-025 from the cell surface to intracellular compartments in the two cell lines. ABY-025 labelled with the high-linear energy transfer α emitter 211 At was also internalised to a higher degree; however, due to its physiological properties, this nuclide was excreted faster. The results indicate that 17-AAG may be used to facilitate cell-specific intracellular localisation of a suitable cytotoxic or radioactive agent coupled to ABY-025 in HER2-overexpressing cells.

  15. proceedings of the 11. Annual meeting of the Federation of Societies on Experimental Biology

    International Nuclear Information System (INIS)


    The proceedings of the 11. Annual meeting of the Federation of Societies on Experimental Biology contains 1850 abstracts, which include the following topics: neuroscience and behaviour; biophysics; pharmacology; comparative physiology; nervous regulation; endocrinology; nefrology; vascular biology; toxicity; molecular biophysics; radiobiology and others. Among these, 169 abstracts have been indexed separately for the INIS database

  16. Study of nuclear fusion in 16O + 64,66ZnE and elastic scattering 16O + 64,68Zn

    International Nuclear Information System (INIS)

    Leiva, C.F.T.


    Excitation functions for the fusion of 16 O with 64 , 66 Zn in the energy range of 0,8 - 1,7 times the coulomb barrier were measured employing gamma-ray techniques to obtain the cross-sections. Elastic scattering angular distributions for the systems 16 O+ 64 , 68 Zn were measured in the energy range 43-56 MeV. (A.C.A.S.) [pt

  17. Abstracts, 21st Annual Meeting Society of Engineering Science, Inc., October 15, 16 and 17, 1984. (United States)


    and hydroxyapatite (HAP) crystal is expected to offer an explation for mineralization alongwith suggestion to design new composite materials (1). In the...the contribution to the presbure field and the deformation of the free surface is zero. The velocity field assumes the form ro l ( Xr ) i t r0 I 1 (-r

  18. Temporal changes in hamlet communities (Hypoplectrus spp., Serranidae) over 17 years. (United States)

    Hench, K; Mcmillan, W O; Betancur-R, R; Puebla, O


    Transect surveys of hamlet communities (Hypoplectrus spp., Serranidae) covering 14 000 m 2 across 16 reefs off La Parguera, Puerto Rico, are presented and compared with a previous survey conducted in the year 2000. The hamlet community has noticeably changed over 17 years, with a > 30% increase in relative abundance of the yellowtail hamlet Hypoplectrus chlorurus on the inner reefs at the expense of the other hamlet species. The data also suggest that the density of H. chlorurus has declined and that its distribution has shifted towards shallower depths. Considering that H. chlorurus has been previously identified as one of the few fish showing a positive association with seawater turbidity on the inner reefs of La Parguera and that sedimentation of terrestrial origin has increased over recent decades on these reefs, it is proposed that turbidity may constitute an important but so far overlooked ecological driver of hamlet communities. © 2017 The Fisheries Society of the British Isles.

  19. NCBI nr-aa BLAST: CBRC-GACU-17-0013 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GACU-17-0013 ref|NP_956379.1| solute carrier family 16 (monocarboxylic acid transporters...), member 1 [Danio rerio] gb|AAH48883.1| Solute carrier family 16 (monocarboxylic acid transporters), member 1 [Danio rerio] NP_956379.1 1e-115 79% ...

  20. 80th Annual Meeting of the Psychometric Society

    CERN Document Server

    Bolt, Daniel; Wang, Wen-Chung; Douglas, Jeffrey; Wiberg, Marie


    The research articles in this volume cover timely quantitative psychology topics, including new methods in item response theory, computerized adaptive testing, cognitive diagnostic modeling, and psychological scaling. Topics within general quantitative methodology include structural equation modeling, factor analysis, causal modeling, mediation, missing data methods, and longitudinal data analysis. These methods will appeal, in particular, to researchers in the social sciences. The 80th annual meeting took place in Beijing, China, between the 12th and 16th of July, 2014. Previous volumes to showcase work from the Psychometric Society’s Meeting are New Developments in Quantitative Psychology: Presentations from the 77th Annual Psychometric Society Meeting (Springer, 2013), Quantitative Psychology Research: The 78th Annual Meeting of the Psychometric Society (Springer, 2015), and Quantitative Psychology Research: The 79th Annual Meeting of the Psychometric Society, Wisconsin, USA, 2014 (Springer, 2015).

  1. Observing and understanding arterial and venous circulation differences in a physiology laboratory activity. (United States)

    Altermann, Caroline; Gonçalves, Rithiele; Lara, Marcus Vinícius S; Neves, Ben-Hur S; Mello-Carpes, Pâmela B


    The purpose of the present article is to describe three simple practical experiments that aim to observe and discuss the anatomic and physiological functions and differences between arteries and veins as well as the alterations observed in skin blood flow in different situations. For this activity, students were divided in small groups. In each group, a volunteer is recruited for each experiment. The experiments only require a sphygmomanometer, rubber bands, and a clock and allow students to develop a hypothesis to explain the different responses to the interruption of arterial and venous blood flow. At the end, students prepare a short report, and the results are discussed. This activity allows students to perceive the presence of physiology in their daily lives and helps them to understand the concepts related to the cardiovascular system and hemodynamics. Copyright © 2015 The American Physiological Society.

  2. A constructivist approach to e-text design for use in undergraduate physiology courses. (United States)

    Rhodes, Ashley E; Rozell, Timothy G


    Electronic textbooks, or e-texts, will have an increasingly important role in college science courses within the next few years due to the rising costs of traditional texts and the increasing availability of software allowing instructors to create their own e-text. However, few guidelines exist in the literature to aid instructors in the development and design specifically of e-texts using sound learning theories; this is especially true for undergraduate physiology e-texts. In this article, we describe why constructivism is a very important educational theory for e-text design and how it may be applied in e-text development by instructors. We also provide examples of two undergraduate physiology e-texts that were designed in accordance with this educational theory but for learners of quite different backgrounds and prior knowledge levels. Copyright © 2015 The American Physiological Society.

  3. Valladolid, a Festival Town (17th-18th Centuries

    Directory of Open Access Journals (Sweden)



    Full Text Available The festival was a great sociocultural event whose dimensions reached their maximum evolution in Early Modern Spain, especially in the 17th and 18th centuries and in its urban centres. This was the «festive society» par excellence, because of the frequency of the celebrations and the multiplicity of meanings, implications and consequences. Society and power, ultimately, were represented at the festival. In this context, the specific case of Valladolid demonstrates both its character as a germane model, applicable to any other town, and its uniqueness. Significantly, in the early 17th century it was once again the seat of the Court and yet even after being abandoned by Philip III in 1606, it continued to be one of the most important towns of Castile, the seat of the Royal Chancellery.

  4. Using ecology to inform physiology studies: implications of high population density in the laboratory. (United States)

    Newman, Amy E M; Edmunds, Nicholas B; Ferraro, Shannon; Heffell, Quentin; Merritt, Gillian M; Pakkala, Jesse J; Schilling, Cory R; Schorno, Sarah


    Conspecific density is widely recognized as an important ecological factor across the animal kingdom; however, the physiological impacts are less thoroughly described. In fact, population density is rarely mentioned as a factor in physiological studies on captive animals and, when it is infrequently addressed, the animals used are reared and housed at densities far above those in nature, making the translation of results from the laboratory to natural systems difficult. We survey the literature to highlight this important ecophysiological gap and bring attention to the possibility that conspecific density prior to experimentation may be a critical factor influencing results. Across three taxa: mammals, birds, and fish, we present evidence from ecology that density influences glucocorticoid levels, immune function, and body condition with the intention of stimulating discussion and increasing consideration of population density in physiology studies. We conclude with several directives to improve the applicability of insights gained in the laboratory to organisms in the natural environment. Copyright © 2015 the American Physiological Society.

  5. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Neonatal Gastrointestinal Physiology and NEC"

    Directory of Open Access Journals (Sweden)

    --- Various Authors


    Full Text Available Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR, European Society for Neonatology (ESN, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNIORGANIZING COMMITTEELuc Zimmermann (President of ESPR, Morten Breindahl (President of ESN, Manuel Sánchez Luna (President of UENPS, Silke Mader (Chairwoman of the Executive Board and Co-Founder of EFCNISCIENTIFIC COMMITTEEVirgilio P. Carnielli (Congress President Chair, Pierre Gressens (Past Scientific President, Umberto Simeoni, Manon Benders, Neil Marlow, Ola D. Saugstad, Petra Hüppi, Agnes van den HoogenSession "Neonatal Gastrointestinal Physiology and NEC"ABS 1. DETRIMENTAL MUCOSAL EFFECT OF IBUPROFEN IN THE IMMATURE HUMAN INTESTINE • E. Tremblay, E. Ferretti, M.-P. Thibault, D. Grynspan, K.M. Burghardt, M. Bettolli, C. Babakissa, E. Levy, J.-F. Beaulieu; Research Consortium on Child Intestinal InflammationABS 2. CORRELATION BETWEEN CALPROTECTIN LEVELS IN MECONIUM AND VITAMIN D STATUS IN CORD BLOOD: ASSOCIATION WITH INTESTINAL DISTRESS DURING NEONATAL PERIOD • S.H. Park, W.H. Kim, Y.M. LeeABS 3. COMPARISON OF FECAL CALPROTECTIN LEVELS ACCORDING TO FEEDING KINDS IN VERY PRETERM INFANTS • J.H. Park, N.H. Lee, S.Y. Shin, C.S. Kim, S.L. Lee, W.M. LeeABS 4. NEONATAL MORBIDITY OF EXTREME PRETERM INFANTS BEFORE AND AFTER THE INTRODUCTION OF A DONOR HUMAN MILK BANK AT THE PERINATAL CENTER GROßHADERN • V. Lieftüchter, M. Kujawa, A. Schuze, A.W. Flemmer, S. Herber-JonatABS 5. IS NEAR INFRARED SPECTROSCOPY A RELIABLE TECHNIQUE TO MEASURE GUT PERFUSION IN PRETERM INFANTS? • J. Banerjee, T.S. Leung, N. AladangadyABS 6. EARLY BIOCHEMICAL MARKERS ASSOCIATED WITH DEVELOPMENT OF NECROTIZING

  6. Calycosin promotes lifespan in Caenorhabditis elegans through insulin signaling pathway via daf-16, age-1 and daf-2. (United States)

    Lu, Lulu; Zhao, Xuan; Zhang, Jianyong; Li, Miao; Qi, Yonghao; Zhou, Lijun


    The naturally occurring calycosin is a known antioxidant that prevents redox imbalance in organisms. However, calycosin's effect on lifespan and its physiological molecular mechanisms are not yet well understood. In this study, we demonstrated that calycosin could prolong the lifespan of Caenorhabditis elegans, and that such extension was associated with its antioxidant capability as well as its ability to enhance stress resistance and reduce ROS (reactive oxygen species) accumulation. To explore mechanisms of this longevity effect, we assessed the impact of calycosin on lifespans of insulin-signaling impaired worms: daf-2, age-1, and daf-16 mutants. We found that calycosin did not alter the lifespan of all three mutants, thereby suggesting that calycosin requires insulin signaling to promote lifespan extension. On the other hand, we observed that calycosin could enhance the nuclear translocation of the core transcription factor DAF-16/FoXO instead of the conserved stress-responsive transcription factor SKN-1/Nrf-2. This observation is consistent with the understanding that the nuclear localized DAF-16 up-regulates its downstream targets sod-3, ctl-1, and hsp-16.2. Lastly, it is also noteworthy that the longevity effect of calycosin is likely not associated with the calorie restriction mechanism. Collectively, our results strongly suggest that calycosin could function as an antioxidant to extend the lifespan of C. elegans by enhancing nucleus translocation of DAF-16 through the insulin-signaling pathway. Copyright © 2017 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  7. 17F breakup reactions: a touchstone for indirect measurements

    International Nuclear Information System (INIS)

    De Napoli, M.; Raciti, G.; Sfienti, C.; Capel, P.; Baye, D.; Descouvemont, P.; Sparenberg, J.-M.; Giacoppo, F.; Rapisarda, E.; Cardella, G.; Mazzocchi, C.


    An exclusive study of 17 F breakup reactions has been performed at the FRIBs facility of the Laboratori Nazionali del Sud in Catania (Italy). The experiment has been performed with the aim of testing the accuracy of the Coulomb-breakup indirect technique used to infer radiative-capture cross sections at low energies. This technique has been used in the 7 Be(p,γ) 8 B case, but has never been tested. By measuring the breakup of 17 F into 16 O+p, and comparing the inferred cross section for 16 O(p,γ) 17 F to direct precise measurements, the influence of E2 transitions and higher-order effects, that are predicted to be significant in Coulomb-breakup reactions, can be evaluated. The first results and preliminary model comparison are reported.

  8. 40. annual convention 1990 of the Austrian physical society

    International Nuclear Information System (INIS)



    Titles and abstracts of the 1990 Convention of the Austrian Physical Society, 17-21 September 1990 at Salzburg, Austria, are given. The topical sections are: 1. Atomic, Molecular- and Plasma Physics; 2. Solid State Physics; 3. Polymer Physics; 4. Nuclear- and Particle Physics; 5. Medical Physics and Biophysics. There are alltogether 193 contributions, 61 thereof of INIS interest

  9. 49 CFR 580.17 - Exemptions. (United States)


    ..., DEPARTMENT OF TRANSPORTATION (CONTINUED) ODOMETER DISCLOSURE REQUIREMENTS § 580.17 Exemptions... Rating, as defined in § 571.3 of this title, of more than 16,000 pounds; (2) A vehicle that is not self... (a) of this section need not notify the lessee of any of these vehicles of the disclosure...

  10. 44 CFR 11.17 - Referral to Department of Justice. (United States)


    ... Justice. 11.17 Section 11.17 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY... Referral to Department of Justice. When Department of Justice approval or consultation is required under § 11.16, the referral or request shall be transmitted to the Department of Justice by the Chief Counsel...

  11. Physiology for engineers applying engineering methods to physiological systems

    CERN Document Server

    Chappell, Michael


    This book provides an introduction to qualitative and quantitative aspects of human physiology. It looks at biological and physiological processes and phenomena, including a selection of mathematical models, showing how physiological problems can be mathematically formulated and studied. It also illustrates how a wide range of engineering and physics topics, including electronics, fluid dynamics, solid mechanics and control theory can be used to describe and understand physiological processes and systems. Throughout the text there are introductions to measuring and quantifying physiological processes using both signal and imaging technologies. Physiology for Engineers describes the basic structure and models of cellular systems, the structure and function of the cardiovascular system, the electrical and mechanical activity of the heart and provides an overview of the structure and function of the respiratory and nervous systems. It also includes an introduction to the basic concepts and applications of reacti...

  12. Effects of prenatal X irradiation on the appearance of reflexes and physiologic markers in the neonatal rat

    International Nuclear Information System (INIS)

    Jensh, R.P.; Brent, R.L.


    Seventy pregnant adult Wistar strain rats were randomly assigned to 1 of 12 exposure groups; 9th or 17th day irradiation at the 0-, 0.1-, 0.2-, 0.4-, 0.6-, or 0.8-Gy dosage level. On the first day of postnatal life, litters were reduced to a maximum of eight pups per litter. A total of 508 pups were observed for the age of acquisition of five reflexes (air righting, surface righting, visual placing, negative geotaxis, auditory startle) and the appearance of four physiologic markers (pinna detachment, eye opening, vaginal opening, testes descent). A dose-response relationship for alterations in reflex acquisition and physiologic marker appearance was observed due to exposure above 0.2 Gy on the 17th day of gestation. Therefore, 0.2 to 0.4-Gy exposure may represent a threshold range for exposure on the 17th day using these postnatal parameters

  13. Reminiscing about Jan Evangelista Purkinje: a pioneer of modern experimental physiology. (United States)

    Cavero, Icilio; Guillon, Jean-Michel; Holzgrefe, Henry H


    This article reminisces about the life and key scientific achievements of Jan Evangelista Purkinje (1787-1869), a versatile 19th century Czech pioneer of modern experimental physiology. In 1804, after completing senior high school, Purkinje joined the Piarist monk order, but, after a 3-yr novitiate, he gave up the religious calling "to deal more freely with science." In 1818, he earned a Medical Doctor degree from Prague University by defending a dissertation on intraocular phenomena observed in oneself. In 1823, Purkinje became a Physiology and Pathology professor at the Prussian Medical University in Breslau, where he innovated the traditional teaching methods of physiology. Purkinje's contributions to physiology were manifold: accurate descriptions of various visual phenomena (e.g., Purkinje-Sanson images, Purkinje phenomenon), discovery of the terminal network of the cardiac conduction system (Purkinje fibers), identification of cerebellar neuronal bodies (Purkinje cells), formulation of the vertigo law (Purkinje's law), discovery of criteria to classify human fingerprints, etc. In 1850, Purkinje accepted and held until his death the Physiology chair at Prague Medical Faculty. During this period, he succeeded in introducing the Czech idiom (in addition to long-established German and Latin) as a Medical Faculty teaching language. Additionally, as a zealous Czech patriot, he actively contributed to the naissance and consolidation of a national Czech identity conscience. Purkinje was a trend-setting scientist who, throughout his career, worked to pave the way for the renovation of physiology from a speculative discipline, ancilla of anatomy, into a factual, autonomous science committed to the discovery of mechanisms governing in-life functions. Copyright © 2017 the American Physiological Society.

  14. The Physiology undergraduate major in the University of Arizona College of Medicine: past, present, and future. (United States)

    Henriksen, Erik J; Atwater, Anne E; Delamere, Nicholas A; Dantzler, William H


    The American Physiological Society (APS) and APS Council encourage the teaching of physiology at the undergraduate, graduate, and medical school levels to support the continued prominence of this area of science. One area identified by the APS Council that is of particular importance for the development of future physiologists (the "physiology pipeline") is the teaching of physiology and physiology-related topics at the undergraduate level. In this article, we describe the historical development and implementation of an undergraduate program offered through the Department of Physiology, a basic science department in the College of Medicine at the University of Arizona, culminating in a Bachelor of Science in Health Sciences degree with a major in Physiology. Moreover, we discuss the current Physiology curriculum offered at our institution and explain how this program prepares our students for successful entry into a variety of postbaccalaureate professional programs, including medical school and numerous other programs in health professions, and in graduate study in the Masters and Doctoral programs in biomedical sciences. Finally, we cover the considerable challenges that we have faced, and continue to face, in developing and sustaining a successful physiology undergraduate major in a college of medicine. We hope that the information provided on the Physiology major offered by the Department of Physiology in the College of Medicine at the University of Arizona will be helpful for individuals at other institutions who may be contemplating the development and implementation of an undergraduate program in Physiology.

  15. Comparative mapping of DNA markers from the familial Alzheimer disease and Down syndrome regions of human chromosome 21 to mouse chromosomes 16 and 17

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, S.V.; Nadeau, J.H.; Tanzi, R.E.; Watkins, P.C.; Jagadesh, J.; Taylor, B.A.; Haines, J.L.; Sacchi, N.; Gusella, J.F. (Harvard Medical School, Boston, MA (USA))


    Mouse trisomy 16 has been proposed as an animal model of Down syndrome (DS), since this chromosome contains homologues of several loci from the q22 band of human chromosome 21. The recent mapping of the defect causing familial Alzheimer disease (FAD) and the locus encoding the Alzheimer amyloid {beta} precursor protein (APP) to human chromosome 21 has prompted a more detailed examination of the extent of conservation of this linkage group between the two species. Using anonymous DNA probes and cloned genes from human chromosome 21 in a combination of recombinant inbred and interspecific mouse backcross analyses, the authors have established that the linkage group shared by mouse chromosome 16 includes not only the critical DS region of human chromosome 21 but also the APP gene and FAD-linked markers. Extending from the anonymous DNA locus D21S52 to ETS2, the linkage map of six loci spans 39% recombination in man but only 6.4% recombination in the mouse. A break in synteny occurs distal to ETS2, with the homologue of the human marker D21S56 mapping to mouse chromosome 17. Conservation of the linkage relationships of markers in the FAD region suggests that the murine homologue of the FAD locus probably maps to chromosome 16 and that detailed comparison of the corresponding region in both species could facilitate identification of the primary defect in this disorder. The break in synteny between the terminal portion of human chromosome 21 and mouse chromosome 16 indicates, however, that mouse trisomy 16 may not represent a complete model of DS.

  16. Comparative mapping of DNA markers from the familial Alzheimer disease and Down syndrome regions of human chromosome 21 to mouse chromosomes 16 and 17

    International Nuclear Information System (INIS)

    Cheng, S.V.; Nadeau, J.H.; Tanzi, R.E.; Watkins, P.C.; Jagadesh, J.; Taylor, B.A.; Haines, J.L.; Sacchi, N.; Gusella, J.F.


    Mouse trisomy 16 has been proposed as an animal model of Down syndrome (DS), since this chromosome contains homologues of several loci from the q22 band of human chromosome 21. The recent mapping of the defect causing familial Alzheimer disease (FAD) and the locus encoding the Alzheimer amyloid β precursor protein (APP) to human chromosome 21 has prompted a more detailed examination of the extent of conservation of this linkage group between the two species. Using anonymous DNA probes and cloned genes from human chromosome 21 in a combination of recombinant inbred and interspecific mouse backcross analyses, the authors have established that the linkage group shared by mouse chromosome 16 includes not only the critical DS region of human chromosome 21 but also the APP gene and FAD-linked markers. Extending from the anonymous DNA locus D21S52 to ETS2, the linkage map of six loci spans 39% recombination in man but only 6.4% recombination in the mouse. A break in synteny occurs distal to ETS2, with the homologue of the human marker D21S56 mapping to mouse chromosome 17. Conservation of the linkage relationships of markers in the FAD region suggests that the murine homologue of the FAD locus probably maps to chromosome 16 and that detailed comparison of the corresponding region in both species could facilitate identification of the primary defect in this disorder. The break in synteny between the terminal portion of human chromosome 21 and mouse chromosome 16 indicates, however, that mouse trisomy 16 may not represent a complete model of DS

  17. Steroidal[17,16-d]pyrimidines derived from dehydroepiandrosterone: A convenient synthesis, antiproliferation activity, structure-activity relationships, and role of heterocyclic moiety (United States)

    Ke, Shaoyong; Shi, Liqiao; Zhang, Zhigang; Yang, Ziwen


    A series of steroidal[17,16-d]pyrimidines derived from dehydroepiandrosterone were designed and prepared by a convenient heterocyclization reaction. The in vitro anticancer activities for these obtained compounds were evaluated against human cancer cell lines (HepG2, Huh-7, and SGC-7901), which demonstrated that some of these heterocyclic pyrimidine derivatives exhibited significantly good cytotoxic activities against all tested cell lines compared with 5-fluorouracil (5-FU), especially, compound 3b exhibited high potential growth inhibitory activities against all tested cell lines with the IC50 values of 5.41 ± 1.34, 5.65 ± 1.02 and 10.64 ± 1.49 μM, respectively, which might be used as promising lead scaffold for discovery of novel anticancer agents. PMID:28290501

  18. An evaluation of the International Society for Animal Genetics recommended parentage and identification panel for the domestic pigeon (Columba livia domestica). (United States)

    de Groot, M; van Haeringen, W A


    In this study, the International Society for Animal Genetics (ISAG) recommended panel for the identification of the domestic pigeon (Columba livia domestica) is characterized based on commonly used statistical parameters. The marker panel is based on 16 short tandem repeat (STR) loci (PIGN15, PIGN10, PIGN57, PIGN26, CliμD16, CliμD19, PIGN12, CliμD17, CliμT17, PIGN04, CliμD01, CliμD11, CliμD35, CliμT02, CliμT13, CliμT43). The alleles of the 16 loci consist of a mixture of tri-, tetra-, penta- and hexameric repeat patterns. A sex determination marker was included in the multiplex for quality control. The repeat sequence of the PIGN markers was previously unpublished and therefore sequenced to reveal the sequence pattern. In total, 1421 pigeons were genotyped on 16 STR loci to generate allele frequency data for each locus. For all 16 markers combined, a PE1 (combined non-exclusion probability, first parent) of 0.9986 and PE2 (combined non-exclusion probability, second parent) of >0.9999 was observed. Comparing the alleged father and mother, a PE value of >0.9999 was observed. Two of the markers, CliμD19 and PIGN12, were found to have relatively high Hardy-Weinberg equilibrium and F(null) values. Therefore these markers may be considered to be replaced by other STRs. Another point of discussion may be to add a gender identification marker to the recommended ISAG panel. Not only can this serve as an extra identification marker, but this can also confirm the sex of a sample, because it is challenging to determine the sex based on phenotypical characteristics, especially for chicks. In conclusion, the set of 16 STR markers can be used in routine parentage verification and the identification of individuals. © 2017 Stichting International Foundation for Animal Genetics.

  19. 16,16-dimethyl prostaglandin E2 increases survival of murine intestinal stem cells when given before photon radiation

    International Nuclear Information System (INIS)

    Hanson, W.R.; Thomas, C.


    A variety of prostaglandins (PG) protect the gastric and intestinal mucosa when given before damaging agents as absolute ethanol, acidified taurocholate, boiling water, or nonsteroidal anti-inflammatory agents (NSAI). A synthetic prostaglandin, 16,16-dimethyl PGE 2 , shown to be cytoprotective at physiologic levels to the above agents was given to mice 1 h before or 15 min after 137 Cs gamma(γ) whole-body irradiation. The survival of intestinal stem cells measured by their ability to form in situ colonies of regenerating epithelium was increased stem cells measured by their ability to form in situ colonies of regenerating epithelium was increased when 16,16-dimethyl PGE 2 was given before but not after 137 Cs γ irradiation. The maximum degree of 16,16-dimethyl PGE 2 -induced radioprotection was seen when the drug was given 1 h before irradiation. No radioprotection was seen when the interval between drug and irradiation was 3 h or longer. When the time between 16,16-dimethyl PGE 2 and irradiation was kept at 1 h, the degree of radioprotection was dependent on the PG drug dose. There was a steep rise in the number of surviving cells at low doses of PG. These results imply that tumors which secrete PGE 2 may in part be protected from the lethal effects of ionizing photon radiation

  20. Rice Physiology (United States)

    P.A. Counce; Davidi R. Gealy; Shi-Jean Susana Sung


    Physiology occurs tn physical space through chemical reactions constrained by anatomy and morphology, yet guided by genetics. Physiology has been called the logic of life. Genes encode structural and fimcdonal proteins. These proteins are subsequently processed to produce enzymes that direct and govern the biomechanical processes involved in the physiology of the...

  1. The evolution of honest communication: integrating social and physiological costs of ornamentation. (United States)

    Tibbetts, Elizabeth A


    Much research on animal communication has addressed how costs such as social costs or physiological costs favor the accuracy of signals. Previous work has largely considered these costs separately, but we may be missing essential connections by studying costs in isolation. After all, social interactions produce rapid changes in hormone titers which can then affect individual behavior and physiology. As a result, social costs are likely to have widespread physiological consequences. Here, I present a new perspective on the factors that maintain honest signals by describing how the interplay between social costs and physiological costs may maintain an accurate link between an animal's abilities and ornament elaboration. I outline three specific mechanisms by which the interaction between social behavior and hormones could favor honest signals and present specific predictions for each of the three models. Then, I review how ornaments alter agonistic behavior, agonistic behavior influences hormones, and how these hormonal effects influence fitness. I also describe the few previous studies that have directly tested how ornaments influence hormones. Finally, opportunities for future work are discussed. Considering the interaction between social behavior and physiology may address some challenges associated with both social and physiological models of costs. Understanding the dynamic feedbacks between physiology and social costs has potential to transform our understanding of the stability of animals' communication systems. © The Author 2014. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email:

  2. Physiological parameters

    International Nuclear Information System (INIS)

    Natera, E.S.


    The physiological characteristics of man depend on the intake, metabolism and excretion of stable elements from food, water, and air. The physiological behavior of natural radionuclides and radionuclides from nuclear weapons testing and from the utilization of nuclear energy is believed to follow the pattern of stable elements. Hence information on the normal physiological processes occurring in the human body plays an important role in the assessment of the radiation dose received by man. Two important physiological parameters needed for internal dose determination are the pulmonary function and the water balance. In the Coordinated Research Programme on the characterization of Asian population, five participants submitted data on these physiological characteristics - China, India, Japan, Philippines and Viet Nam. During the CRP, data on other pertinent characteristics such as physical and dietary were simultaneously being collected. Hence, the information on the physiological characteristics alone, coming from the five participants were not complete and are probably not sufficient to establish standard values for the Reference Asian Man. Nonetheless, the data collected is a valuable contribution to this research programme

  3. Isotope separation of 17O by photodissociation of ozone with near-infrared laser irradiation (United States)

    Hayashida, Shigeru; Kambe, Takashi; Sato, Tetsuya; Igarashi, Takehiro; Kuze, Hiroaki


    Oxygen-17 is a stable oxygen isotope useful for various diagnostics in both engineering and medical applications. Enrichment of 17O, however, has been very costly due to the lack of appropriate methods that enable efficient production of 17O on an industrial level. In this paper, we report the first 17O-selective photodissociation of ozone at a relatively high pressure, which has been achieved by irradiating a gas mixture of 10 vol% O3-90 vol% CF4 with narrowband laser. The experiment was conducted on a pilot-plant scale. A total laser power of 1.6 W was generated by external-cavity diode lasers with all the laser wavelengths fixed at the peak of an absorption line of 16O16O17O around 1 μm. The beams were introduced into a 25 -m long photoreaction cell under the sealed-off condition with a total pressure of 20 kPa. Lower cell temperature reduced the background decomposition of ozone, and at the temperature of 158 K, an 17O enrichment factor of 2.2 was attained.

  4. Time course of physiological and psychological responses in humans during a 20-day severe-cold-acclimation programme.

    Directory of Open Access Journals (Sweden)

    Marius Brazaitis

    Full Text Available The time course of physiological and psychological markers during cold acclimation (CA was explored. The experiment included 17 controlled (i.e., until the rectal temperature reached 35.5°C or 170 min had elapsed; for the CA-17 session, the subjects (n = 14 were immersed in water for the same amount of time as that used in the CA-1 session head-out water immersions at a temperature of 14°C over 20 days. The data obtained in this study suggest that the subjects exhibited a thermoregulatory shift from peripheral-to-central to solely central input thermoregulation, as well as from shivering to non-shivering thermogenesis throughout the CA. In the first six CA sessions, a hypothermic type of acclimation was found; further CA (CA-7 to CA-16 led to a transitional shift to a hypothermic-insulative type of acclimation. Interestingly, when the subjects were immersed in water for the same time as that used in the CA-1 session (CA-17, the CA led to a hypothermic type of acclimation. The presence of a metabolic type of thermogenesis was evident only under thermoneutral conditions. Cold-water immersion decreased the concentration of cold-stress markers, reduced the activity of the innate immune system, suppressed specific immunity to a lesser degree and yielded less discomfort and cold sensation. We found a negative correlation between body mass index and Δ metabolic heat production before and after CA.

  5. PERARES : Public Engagement with Research and Research Engagement with Society

    NARCIS (Netherlands)

    Mulder, Henk; Steinhaus, Norbert; Azman, Azlinda; Arlus, Feri; Jamsari, A; Campbell, James; Steinhaus, Norbert; Ong, Tan Kek; Winyayong, Panom


    PERARES is a four years funded project by the European Community's Seventh Framework Program which started in 2010. It brings together Science Shops, Civil Society Organisations (CSOs) and Universities from 16 European countries. The PERARES project aims to strengthen public engagement in research

  6. Proceedings of the Canadian Nuclear Society 15. annual conference

    Energy Technology Data Exchange (ETDEWEB)

    Huynh, H M [Hydro-Quebec, Montreal, PQ (Canada)


    The proceedings of the 15. annual conference of the Canadian Nuclear Society cover a wide range of nuclear topics, but the emphasis is on CANDU reactors and Canadian experience. The 89 papers are arranged in 17 sessions dealing with the following subjects: thermalhydraulics, fuel channels, operations, reactor physics, fuel, new technology, safety, training, waste management. The individual papers have been abstracted separately.

  7. Proceedings of the Canadian Nuclear Society 15. annual conference

    International Nuclear Information System (INIS)

    Huynh, H.M.


    The proceedings of the 15. annual conference of the Canadian Nuclear Society cover a wide range of nuclear topics, but the emphasis is on CANDU reactors and Canadian experience. The 89 papers are arranged in 17 sessions dealing with the following subjects: thermalhydraulics, fuel channels, operations, reactor physics, fuel, new technology, safety, training, waste management. The individual papers have been abstracted separately

  8. A Disintegrin and Metalloprotease 17 in the Cardiovascular and Central Nervous Systems. (United States)

    Xu, Jiaxi; Mukerjee, Snigdha; Silva-Alves, Cristiane R A; Carvalho-Galvão, Alynne; Cruz, Josiane C; Balarini, Camille M; Braga, Valdir A; Lazartigues, Eric; França-Silva, Maria S


    ADAM17 is a metalloprotease and disintegrin that lodges in the plasmatic membrane of several cell types and is able to cleave a wide variety of cell surface proteins. It is somatically expressed in mammalian organisms and its proteolytic action influences several physiological and pathological processes. This review focuses on the structure of ADAM17, its signaling in the cardiovascular system and its participation in certain disorders involving the heart, blood vessels, and neural regulation of autonomic and cardiovascular modulation.


    Directory of Open Access Journals (Sweden)

    Jiaxi Xu


    Full Text Available ADAM17 is a metalloprotease and disintegrin that lodges in the plasmatic membrane of several cell types and is able to cleave a wide variety of cell surface proteins. It is somatically expressed in mammalian organisms and its proteolytic action influences several physiological and pathological processes. This review focuses on the structure of ADAM17, its signaling in the cardiovascular system and its participation in certain disorders involving the heart, blood vessels and neural regulation of autonomic and cardiovascular modulation.

  10. Alteration of plant physiology by glyphosate and its by-product aminomethylphosphonic acid: an overview. (United States)

    Gomes, Marcelo P; Smedbol, Elise; Chalifour, Annie; Hénault-Ethier, Louise; Labrecque, Michel; Lepage, Laurent; Lucotte, Marc; Juneau, Philippe


    It is generally claimed that glyphosate kills undesired plants by affecting the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) enzyme, disturbing the shikimate pathway. However, the mechanisms leading to plant death may also be related to secondary or indirect effects of glyphosate on plant physiology. Moreover, some plants can metabolize glyphosate to aminomethylphosphonic acid (AMPA) or be exposed to AMPA from different environmental matrices. AMPA is a recognized phytotoxin, and its co-occurrence with glyphosate could modify the effects of glyphosate on plant physiology. The present review provides an overall picture of alterations of plant physiology caused by environmental exposure to glyphosate and its metabolite AMPA, and summarizes their effects on several physiological processes. It particularly focuses on photosynthesis, from photochemical events to C assimilation and translocation, as well as oxidative stress. The effects of glyphosate and AMPA on several plant physiological processes have been linked, with the aim of better understanding their phytotoxicity and glyphosate herbicidal effects. © The Author 2014. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email:

  11. Molecular and physiological manifestations and measurement of aging in humans. (United States)

    Khan, Sadiya S; Singer, Benjamin D; Vaughan, Douglas E


    Biological aging is associated with a reduction in the reparative and regenerative potential in tissues and organs. This reduction manifests as a decreased physiological reserve in response to stress (termed homeostenosis) and a time-dependent failure of complex molecular mechanisms that cumulatively create disorder. Aging inevitably occurs with time in all organisms and emerges on a molecular, cellular, organ, and organismal level with genetic, epigenetic, and environmental modulators. Individuals with the same chronological age exhibit differential trajectories of age-related decline, and it follows that we should assess biological age distinctly from chronological age. In this review, we outline mechanisms of aging with attention to well-described molecular and cellular hallmarks and discuss physiological changes of aging at the organ-system level. We suggest methods to measure aging with attention to both molecular biology (e.g., telomere length and epigenetic marks) and physiological function (e.g., lung function and echocardiographic measurements). Finally, we propose a framework to integrate these molecular and physiological data into a composite score that measures biological aging in humans. Understanding the molecular and physiological phenomena that drive the complex and multifactorial processes underlying the variable pace of biological aging in humans will inform how researchers assess and investigate health and disease over the life course. This composite biological age score could be of use to researchers seeking to characterize normal, accelerated, and exceptionally successful aging as well as to assess the effect of interventions aimed at modulating human aging. © 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

  12. Summary of FY 17 Assessments Sandia National Laboratories: Evaluation of FY16 SNL FCT M2 Milestone Deliverables

    Energy Technology Data Exchange (ETDEWEB)

    Appel, Gordon John


    This report is the milestone deliverable M4FT-17SN111102091 “Summary of Assessments Performed FY17 by SNL QA POC” for work package FT-17SN11110209 titled “Quality Assurance – SNL”. This report summarizes the FY17 assessment performed on Fuel Cycle Technologies / Spent Fuel and Waste Disposition efforts.

  13. Sleep and Physiological Dysregulation: A Closer Look at Sleep Intraindividual Variability. (United States)

    Bei, Bei; Seeman, Teresa E; Carroll, Judith E; Wiley, Joshua F


    Variable daily sleep (ie, higher intraindividual variability; IIV) is associated with negative health consequences, but potential physiological mechanisms are poorly understood. This study examined how the IIV of sleep timing, duration, and quality is associated with physiological dysregulation, with diurnal cortisol trajectories as a proximal outcome and allostatic load (AL) as a multisystem distal outcome. Participants are 436 adults (Mage ± standard deviation = 54.1 ± 11.7, 60.3% women) from the Midlife in the United States study. Sleep was objectively assessed using 7-day actigraphy. Diurnal cortisol was measured via saliva samples (four/day for 4 consecutive days). AL was measured using 23 biomarkers from seven systems (inflammatory, hypothalamic-pituitary-adrenal axis, metabolic glucose and lipid, cardiovascular, parasympathetic, sympathetic) using a validated bifactor model. Linear and quadratic effects of sleep IIV were estimated using a validated Bayesian model. Controlling for covariates, more variable sleep timing (p = .04 for risetime, p = .097 for bedtime) and total sleep time (TST; p = .02), but not mean sleep variables, were associated with flatter cortisol diurnal slope. More variable sleep onset latency and wake after sleep onset, later average bedtime, and shorter TST were associated with higher AL adjusting for age and sex (p-values sleep patterns were associated with blunted diurnal cortisol trajectories but not with higher multisystem physiological dysregulation. The associations between sleep IIV and overall health are likely complex, including multiple biopsychosocial determinants and require further investigation. © Sleep Research Society 2017. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail

  14. Physiological stress response patterns during a blood donation. (United States)

    Hoogerwerf, M D; Veldhuizen, I J T; Tarvainen, M P; Merz, E-M; Huis In 't Veld, E M J; de Kort, W L A M; Sluiter, J K; Frings-Dresen, M H W


    Donating blood is associated with increased psychological stress. This study investigates whether a blood donation induces physiological stress and if response patterns differ by gender, donation experience and non-acute stress. In 372 donors, physiological stress [blood pressure, pulse rate, pulse rate variability (PRV)] was measured at seven moments during routine donation. PRV was assessed using time domain [root mean square of successive differences (RMSSD)] and frequency domain [high frequency (HF) and low frequency (LF) power] parameters. Non-acute stress was assessed by questionnaire. Shape and significance of time course patterns were assessed by fitting multilevel models for each stress measure and comparing men and women, first-time and experienced donors, and donors with high and low levels of non-acute stress. Significant response patterns were found for all stress measures, where levels of systolic blood pressure (F(1,1315) = 24·2, P blood pressure (F(1,1326) = 50·9, P blood pressure/pulse rate in women; higher pulse rate in first-time donors; higher RMSSD at arrival and from screening until leaving in first-time donors; and higher LF and HF in first-time donors. This study shows an increase in physiological stress related to needle insertion, followed by a decrease when leaving the donation centre. Some group effects were also found. © 2018 International Society of Blood Transfusion.

  15. Physiological and psychological effects of gardening activity in older adults. (United States)

    Hassan, Ahmad; Qibing, Chen; Tao, Jiang


    Gardening has long been one of most enjoyable pastimes among older adults. Whether gardening activities contribute to the well-being of older adults is a major question. Therefore, the aim of the present study was to clarify the psychophysiological relaxing effects of gardening activities on older adults living in modern institutional care. The study participants were 40 older women aged 79.5 ± 8.09 years (mean ± SD). A cross-over study design was used to investigate the physiological and psychological responses to environments with and without plants. Physiological evaluation was carried out using blood pressure and electroencephalography, and psychological evaluation was carried out using the State-Trait Anxiety Inventory and Semantic Differential method. Blood pressure was significantly lower, and changes in brainwaves were observed. Psychological responses showed that participants were more "comfortable and relaxed" after the plant task than after the control task. In addition, total anxiety levels were significantly lower after carrying out the plant task than after the control task. Our research suggests that gardening activities might enhance physiological and psychological relaxation in older adults. Geriatr Gerontol Int 2018; ••: ••-••. © 2018 Japan Geriatrics Society.

  16. Proceedings of the Korean Society Nuclear Medicine Spring Meeting 2002

    International Nuclear Information System (INIS)


    This proceedings contains articles of 2002 Spring meeting of the Korean Society Nuclear Medicine. It was held on May 17, 2002 in Suwon, Korea. This proceedings is comprised of 3 sessions. The subject titles of session are as follows: Gynecological and Colorectal cancer, Lung cancer and Lymphoma, and general nuclear medicine. (Yi, J. H.)

  17. 16,16-dimethyl prostaglandin E/sub 2/ increases survival of murine intestinal stem cells when given before photon radiation

    Energy Technology Data Exchange (ETDEWEB)

    Hanson, W.R.; Thomas, C.


    A variety of prostaglandins (PG) protect the gastric and intestinal mucosa when given before damaging agents as absolute ethanol, acidified taurocholate, boiling water, or nonsteroidal anti-inflammatory agents (NSAI). A synthetic prostaglandin, 16,16-dimethyl PGE/sub 2/, shown to be cytoprotective at physiologic levels to the above agents was given to mice 1 h before or 15 min after /sup 137/Cs gamma(..gamma..) whole-body irradiation. The survival of intestinal stem cells measured by their ability to form in situ colonies of regenerating epithelium was increased stem cells measured by their ability to form in situ colonies of regenerating epithelium was increased when 16,16-dimethyl PGE/sub 2/ was given before but not after /sup 137/Cs ..gamma.. irradiation. The maximum degree of 16,16-dimethyl PGE/sub 2/-induced radioprotection was seen when the drug was given 1 h before irradiation. No radioprotection was seen when the interval between drug and irradiation was 3 h or longer. When the time between 16,16-dimethyl PGE/sub 2/ and irradiation was kept at 1 h, the degree of radioprotection was dependent on the PG drug dose. There was a steep rise in the number of surviving cells at low doses of PG. These results imply that tumors which secrete PGE/sub 2/ may in part be protected from the lethal effects of ionizing photon radiation.

  18. 17β-Hydroxysteroid dehydrogenase type 13 is a liver-specific lipid droplet-associated protein

    International Nuclear Information System (INIS)

    Horiguchi, Yuka; Araki, Makoto; Motojima, Kiyoto


    17β-Hydroxysteroid dehydrogenase (17βHSD) type 13 is identified as a new lipid droplet-associated protein. 17βHSD type 13 has an N-terminal sequence similar to that of 17βHSD type 11, and both sequences function as an endoplasmic reticulum and lipid droplet-targeting signal. Localization of native 17βHSD type 13 on the lipid droplets was confirmed by subcellular fractionation and Western blotting. In contrast to 17βHSD type 11, however, expression of 17βHSD type 13 is largely restricted to the liver and is not enhanced by peroxisome proliferator-activated receptor α and its ligand. Instead the expression level of 17βHSD type 13 in the receptor-null mice was increased several-fold. 17βHSD type 13 may have a distinct physiological role as a lipid droplet-associated protein in the liver

  19. Chemical and biological data collected as part of the CArbon Retention In A Colored Ocean (CARIACO) program in the Cariaco Basin off the coast of Venezuela, January 17, 2005 - January 16, 2006 (NODC Accession 0013170) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Chemical and biological data were collected using bottle casts on the continental shelf of Venezuela from the HERMANO GINES from January 17, 2005 to January 16,...

  20. [Representation of women in health-related scientific societies in Spain in 2014]. (United States)

    Casado-Mejía, Rosa; Botello-Hermosa, Alicia


    To describe the presence of women in the governance of health-related scientific societies in Spain today. Spanish scientific societies were identified by vising the websites of the Ministry of Health, Social Services and Equality, and Fisterra. The sex of the president, executive officers and the board of directors was identified. Data were analyzed according to the overall percentage of women and by profession and setting. Of 173 scientific societies in July 2014, 41 had a female president (22.53%). Women held 35.45% of executive positions and accounted for 36.32% of the boards of directors. Only 16.07% of medical societies had a female president compared with 76.92% of nursing societies. Primary care societies had more women in executive positions (54.55%) than societies in which the professional activity of members involved both primary and secondary care (35.74%) and societies related to hospital care (27.93%). There is a lack of parity, which is greater in nursing and primary care societies than in medical and hospital-related societies. Parity decreases as the level of responsibility rises. Copyright © 2014 SESPAS. Published by Elsevier Espana. All rights reserved.

  1. Analysis of Medicine Prices in New Zealand and 16 European Countries. (United States)

    Vogler, Sabine; Kilpatrick, Kate; Babar, Zaheer-Ud-Din


    To compare prices of medicines, both originators and generics, in New Zealand and 16 European countries. Ex-factory price data as of December 2012 from New Zealand and 16 European countries were compared for a basket of 14 medicines, most of which were at least partially funded by the state in the 17 countries. Five medicines had, at least in some countries, generic versions on the market whose prices were also analyzed. Medicine price data for the 16 European countries were provided by the Pharma Price Information service. New Zealand medicine prices were retrieved from the New Zealand Pharmaceutical Schedule. Unit prices converted into euro were compared at the ex-factory price level. For the 14 medicines surveyed, considerable price differences at the ex-factory price level were identified. Within the European countries, prices in Greece, Portugal, the United Kingdom, and Spain ranked at the lower end, whereas prices in Switzerland, Germany, Denmark, and Sweden were at the upper end. The results for New Zealand compared with Europe were variable. New Zealand prices were found in the lowest quartile for five medicines and in the highest quartile for seven other products. Price differences between the originator products and generic versions ranged from 0% to 90% depending on the medicine and the country. Medicine prices varied considerably between European countries and New Zealand as well as among the European countries. These differences are likely to result from national pricing and reimbursement policies. Copyright © 2015 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  2. Use of a physiological profile to document motor impairment in ageing and in clinical groups. (United States)

    Lord, S R; Delbaere, K; Gandevia, S C


    Ageing decreases exercise performance and is frequently accompanied by reductions in cognitive performance. Deterioration in the physiological capacity to stand, locomote and exercise can manifest itself as falling over and represents a significant deterioration in sensorimotor control. In the elderly, falling leads to serious morbidity and mortality with major societal costs. Measurement of a suite of physiological capacities that are required for successful motor performance (including vision, muscle strength, proprioception and balance) has been used to produce a physiological profile assessment (PPA) which has been tracked over the age spectrum and in different diseases (e.g. multiple sclerosis, Parkinson's disease). As well as measures of specific physiological capacities, the PPA generates an overall 'score' which quantitatively measures an individual's cumulative risk of falling. The present review collates data from the PPA (and the physiological capacities it measures) as well as its use in strategies to reduce falls in the elderly and those with different diseases. We emphasise that (i) motor impairment arises via reductions in a wide range of sensorimotor abilities; (ii) the PPA approach not only gives a snapshot of the physiological capacity of an individual, but it also gives insight into the deficits among groups of individuals with particular diseases; and (iii) deficits in seemingly restricted and disparate physiological domains (e.g. vision, strength, cognition) are funnelled into impairments in tasks requiring upright balance. Motor impairments become more prevalent with ageing but careful physiological measurement and appropriate interventions offer a way to maximise health across the lifespan. © 2015 The Authors. The Journal of Physiology © 2015 The Physiological Society.

  3. Conservation Physiology and Conservation Pathogens: White-Nose Syndrome and Integrative Biology for Host-Pathogen Systems. (United States)

    Willis, Craig K R


    Conservation physiology aims to apply an understanding of physiological mechanisms to management of imperiled species, populations, or ecosystems. One challenge for physiologists hoping to apply their expertise to conservation is connecting the mechanisms we study, often in the laboratory, with the vital rates of populations in the wild. There is growing appreciation that infectious pathogens can threaten populations and species, and represent an important issue for conservation. Conservation physiology has much to offer in terms of addressing the threat posed to some host species by infectious pathogens. At the same time, the well-developed theoretical framework of disease ecology could provide a model to help advance the application of physiology to a range of other conservation issues. Here, I use white-nose syndrome (WNS) in hibernating North American bats as an example of a conservation problem for which integrative physiological research has been a critical part of research and management. The response to WNS highlights the importance of a well-developed theoretical framework for the application of conservation physiology to a particular threat. I review what is known about physiological mechanisms associated with mortality from WNS and emphasize the value of combining a strong theoretical background with integrative physiological studies in order to connect physiological mechanisms with population processes and thereby maximize the potential benefits of conservation physiology. © The Author 2015. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email:

  4. Effects of mental workload on physiological and subjective responses during traffic density monitoring: A field study. (United States)

    Fallahi, Majid; Motamedzade, Majid; Heidarimoghadam, Rashid; Soltanian, Ali Reza; Miyake, Shinji


    This study evaluated operators' mental workload while monitoring traffic density in a city traffic control center. To determine the mental workload, physiological signals (ECG, EMG) were recorded and the NASA-Task Load Index (TLX) was administered for 16 operators. The results showed that the operators experienced a larger mental workload during high traffic density than during low traffic density. The traffic control center stressors caused changes in heart rate variability features and EMG amplitude, although the average workload score was significantly higher in HTD conditions than in LTD conditions. The findings indicated that increasing traffic congestion had a significant effect on HR, RMSSD, SDNN, LF/HF ratio, and EMG amplitude. The results suggested that when operators' workload increases, their mental fatigue and stress level increase and their mental health deteriorate. Therefore, it maybe necessary to implement an ergonomic program to manage mental health. Furthermore, by evaluating mental workload, the traffic control center director can organize the center's traffic congestion operators to sustain the appropriate mental workload and improve traffic control management. Copyright © 2015 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  5. Physiologic profile of professional cricketers. (United States)

    Johnstone, James A; Ford, Paul A


    This study aims to provide a physiologic profile of professional cricketers and note positional differences at the start of the 2007/08 competitive season. Fifteen participants (9 bowlers, 6 batsmen) aged 25.0 ± 5.0 years (mean ± SD) took part in this study. Participants (bowlers and batsmen) completed a series of field-based fitness assessments: body composition (sum of 7 skinfolds, 72.5 ± 16.5 and 65.5 ± 19.3 mm, respectively), flexibility (sit and reach 8.1 ± 10.3 and 6.0 ± 6.2 cm, respectively), predicted maximal oxygen uptake (multistage shuttle run, 54.1 ± 2.8 and 56.1 ± 4.5 ml-1·kg-1·min-1, respectively), upper- (medicine ball throw, 7.7 ± 0.6 and 7.0 ± 0.1 m, respectively) and lower-body strength (countermovement jump, 45.7 ± 5.8 and 43.9 ± 4.1 cm, respectively), speed (sprint 17.7 m, 2.76 ± 0.6 and 2.77 ± 0.1 s, respectively), and explosive power (repeated jump, 31.0 ± 2.0 and 34.1 ± 4.8 cm, respectively). The data provided the physical fitness profile for each player, which, compared with normative data, identified that this cohort of professional cricketers had some superior fitness parameters compared with the general population, and where applicable, were comparable with other professional athletes. In addition, after effect size calculations, the results showed that some physical fitness differences existed between playing positions. Cricket professionals possess a superior level of physical fitness and strength, and conditioning coaches should seek to progress these physical parameters and further identify position-specific physical requirements to progress the modern game.

  6. Studies with 17 beta(16 alpha-[125I]iodo)-estradiol, an estrogen receptor-binding radiopharmaceutical, in rats bearing mammary tumors

    International Nuclear Information System (INIS)

    Gatley, S.J.; Shaughnessy, W.J.; Inhorn, L.; Leiberman, L.M.


    We have studied the distribution of 17 beta(16 alpha-[125I]iodo)-estradiol (I-E2) in tumor-bearing and normal rats. High early adrenal-to-blood ratios (up to 22 at 5 min) were seen in all groups, but this fell to six at 1 hr. Uterus-to-blood ratios of 15 were found, and these were fairly constant up to 2 hr after administration. Uptake of label in the uterus, but not in the adrenals, was sensitive to excess diethylstilbestrol, which competes with I-E2 for estrogen receptors. Mean tumor-to-blood ratios of 1.4, 5.5, and 8.7 were seen at 1 hr in rats with transplanted, spontaneous, and N-nitrosomethylurea-induced tumors, respectively. Diethylstilbestrol was shown to reduce uptake of label by spontaneous tumors. Most of the radioactivity was excreted in the bile by 1 hr. Better estrogen-receptor-binding radiopharmaceuticals can probably be designed

  7. Physiologic quality of sweet maize seeds according to thickness and width

    Directory of Open Access Journals (Sweden)

    Claudemir Zucareli


    Full Text Available Sweet maize seeds present lower physiologic quality, when compared to regular maize seeds, due to the influence of several features, such as the seed size and shape. Thus, this study aimed at evaluating the seed physiologic quality of two sweet maize cultivars (BR-401 and BR-402, separately classified according to thickness, by using slotted screen sieves (8/64" x 3/4, 9/64" x 3/4, 10/64" x 3/4, 11/64" x 3/4, 12/64" x 3/4 and 13/64" x 3/4, and width, with round screen sieves (17/64", 18/64", 19/64", 20/64", 21/64" and 22/64". For each cultivar, sorted lots were compared with the unrated batch, following a completely randomized design, in a 2x7 factorial scheme, with four replications. The biometric parameters evaluated were sieve retention, 100 seeds weight and water content. The physiologic quality was determined according to the first counting, germination, cold test, accelerated aging, electric conductivity and seedling emergence in the field. The classification with sieves improved the physiologic quality of sweet maize seeds. Seeds with intermediate thickness, for both cultivars, generally presented greater vigor. Concerning width, larger seeds, for the BR-401 cultivar, and intermediate seeds, for the BR-402 cultivar, showed better physiologic quality.

  8. 2016 Annual Meeting of the Canadian Society for History and Philosophy of Mathematics

    CERN Document Server

    Schlimm, Dirk


    This volume contains fourteen papers that were presented at the 2016 Annual Meeting of the Canadian Society for History and Philosophy of Mathematics/La Société Canadienne d’Histoire et de Philosophie des Mathématiques, held at the University of Calgary in Alberta, Canada. In addition to showcasing rigorously reviewed modern scholarship on an interesting variety of topics in the history and philosophy of mathematics, this meeting also honored the life and work of the logician and philosopher of mathematics Aldo Antonelli (1962-2015). The first four papers in this book are part of that remembrance and have a philosophical focus. Included in these are a discussion of Bolzano’s objections to Kant’s philosophy of mathematics and an examination of the influence of rhetorical and poetic aesthetics on the development of symbols in the 16th and 17thCenturies. The remaining papers deal with the history of mathematics and cover such subjects as Early schemes for polar ordinates in the work of L’Hôpital, bas...

  9. Children's Play and Culture Learning in an Egalitarian Foraging Society. (United States)

    Boyette, Adam H


    Few systematic studies of play in foragers exist despite their significance for understanding the breadth of contexts for human development and the ontogeny of cultural learning. Forager societies lack complex social hierarchies, avenues for prestige or wealth accumulation, and formal educational institutions, and thereby represent a contrast to the contexts of most play research. Analysis of systematic observations of children's play among Aka forest foragers (n = 50, ages 4-16, M = 9.5) and Ngandu subsistence farmers (n = 48, ages 4-16, M = 9.1) collected in 2010 illustrates that while play and work trade off during development in both groups, and consistent patterns in sex-role development are evident, Aka children engage in significantly less rough-and-tumble play and competitive games than children among their socially stratified farming neighbors. © 2016 The Authors. Child Development © 2016 Society for Research in Child Development, Inc.

  10. Exclusive measurements of nuclear breakup reactions of 17Ne

    International Nuclear Information System (INIS)

    Wamers, F.; Marganiec, J.; Aksouh, F.; Aksyutina, Y.; Boretzky, K.; Chatillon, A.; Emling, H.; Geissel, H.; Heil, M.; Hoffmann, J.; Karagiannis, C.; Kiselev, O.A.; Kurz, N.; Larsson, K.; Litvinov, Y.A.; Nociforo, C.; Ott, W.; Simon, H.; Suemmerer, K.; Weick, H.; Alvarez-Pol, H.; Beceiro-Novo, S.; Cortina-Gil, D.; Rodriguez-Tajes, C.; Aumann, T.; Panin, V.; Bertulani, C.A.; Borge, M.J.G.; Galaviz, D.; Perea, A.; Tengblad, O.; Chartier, M.; Taylor, J.; Chulkov, L.V.; Egorova, I.A.; Ershova, O.; Langer, C.; Plag, R.; Reifarth, R.; Wimmer, C.; Forssen, C.; Johansson, H.; Jonson, B.; Nilsson, T.; Nyman, G.; Tengborn, E.; Zhukov, M.V.; Fraile, L.M.; Fynbo, H.; Riisager, K.; Grigorenko, L.V.; Hoffmann, D.H.; Richter, A.; Schrieder, G.; Karakoc, M.; Kratz, J.V.; Kulessa, R.; Lantz, M.; Le Bleis, T.; Lemmon, R.; Mahata, K.; Muentz, C.; Stroth, J.; Parfenova, Y.L.; Paschalis, S.; Rossi, D.; Savran, D.; Shul'gina, N.B.


    We have studied one-proton-removal reactions of about 500 MeV/u 17 Ne beams on a carbon target at the R 3 B/LAND setup at GSI by detecting beam-like 15 O-p and determining their relative-energy distribution. We exclusively selected the removal of a 17 Ne halo proton, and the Glauber-model analysis of the 16 F momentum distribution resulted in an s 2 contribution in the 17 Ne ground state of about 40 %. (authors)

  11. Effect of a puzzle on the process of students' learning about cardiac physiology. (United States)

    Cardozo, Lais Tono; Miranda, Aline Soares; Moura, Maria José Costa Sampaio; Marcondes, Fernanda Klein


    The aim of the present study was to evaluate the effects of using a puzzle to learn about cardiac physiology. Students were divided into control and game groups. In class 1, the control group had a 2-h theoretical class about cardiac physiology, including a detailed description of the phases of the cardiac cycle, whereas the game group had a 50-min theoretical class without the description of the cardiac cycle. In class 2, the control group did an assessment exercise before an activity with the cardiac puzzle and the game group answered questions after the above-mentioned activity. While solving the puzzle, the students had to describe the cardiac cycle by relating the concepts of heart morphology and physiology. To evaluate short-term learning, the number of wrong answers and grades in the assessment exercise were compared between the control and game groups. To evaluate medium-term learning, we compared the grades obtained by students of the control and game groups in questions about cardiac physiology that formed part of the academic exam. In the assessment exercise, the game group presented a lower number of errors and higher score compared with the control group. In the academic exam, applied after both groups had used the puzzle, there was no difference in the scores obtained by the control and game groups in questions about cardiac physiology. These results showed a positive effect of the puzzle on students' learning about cardiac physiology compared with those not using the puzzle. Copyright © 2016 The American Physiological Society.

  12. Syndromes of collateral-reported psychopathology for ages 18-59 in 18 Societies (United States)

    Ivanova, Masha Y.; Achenbach, Thomas M.; Rescorla, Leslie A.; Turner, Lori V.; Árnadóttir, Hervör Alma; Au, Alma; Caldas, J. Carlos; Chaalal, Nebia; Chen, Yi Chuen; da Rocha, Marina M.; Decoster, Jeroen; Fontaine, Johnny R.J.; Funabiki, Yasuko; Guðmundsson, Halldór S.; Kim, Young Ah; Leung, Patrick; Liu, Jianghong; Malykh, Sergey; Marković, Jasminka; Oh, Kyung Ja; Petot, Jean-Michel; Samaniego, Virginia C.; Silvares, Edwiges Ferreira de Mattos; Šimulionienė, Roma; Šobot, Valentina; Sokoli, Elvisa; Sun, Guiju; Talcott, Joel B.; Vázquez, Natalia; Zasępa, Ewa


    The purpose was to advance research and clinical methodology for assessing psychopathology by testing the international generalizability of an 8-syndrome model derived from collateral ratings of adult behavioral, emotional, social, and thought problems. Collateral informants rated 8,582 18–59-year-old residents of 18 societies on the Adult Behavior Checklist (ABCL). Confirmatory factor analyses tested the fit of the 8-syndrome model to ratings from each society. The primary model fit index (Root Mean Square Error of Approximation) showed good model fit for all societies, while secondary indices (Tucker Lewis Index, Comparative Fit Index) showed acceptable to good fit for 17 societies. Factor loadings were robust across societies and items. Of the 5,007 estimated parameters, 4 (0.08%) were outside the admissible parameter space, but 95% confidence intervals included the admissible space, indicating that the 4 deviant parameters could be due to sampling fluctuations. The findings are consistent with previous evidence for the generalizability of the 8-syndrome model in self-ratings from 29 societies, and support the 8-syndrome model for operationalizing phenotypes of adult psychopathology from multi-informant ratings in diverse societies. PMID:29399019

  13. 17β-Estradiol-induced interaction of ERα with NPPA regulates gene expression in cardiomyocytes. (United States)

    Mahmoodzadeh, Shokoufeh; Pham, Thi Hang; Kuehne, Arne; Fielitz, Britta; Dworatzek, Elke; Kararigas, Georgios; Petrov, George; Davidson, Mercy M; Regitz-Zagrosek, Vera


    17β-Oestradiol (E2) and its receptors (ERα and ERβ) are important regulators of physiological and pathological processes in the cardiovascular system. ER act in concert with other regulatory factors mediating oestrogenic effects. However, the underlying mechanisms modulating ER transcriptional activity are not fully elucidated. To gain better understanding of E2-induced ERα action in the human heart, we aimed to identify and functionally analyse interaction partners of ERα. Using yeast two-hybrid assays with a human heart cDNA library, we identified atrial natriuretic peptide precursor A (NPPA), a well-known cardiac hypertrophy marker, as a novel ERα interaction partner interacting in an E2-dependent manner. Mutation analyses and immunofluorescence data indicated that the LXXLL motif within NPPA is necessary for its E2-induced interaction with ERα, its action as a co-repressor of ERα, and its translocation into the nucleus of human and rat cardiomyocytes. Expression analysis and chromatin immunoprecipitation assays in a human left ventricular cardiomyocyte cell line, AC16, showed that NPPA interacts with E2/ERα, suppressing the transcriptional activity of ERα on E2-target genes, such as NPPA, connexin43, αactinin-2, nuclear factor of activated T-cells, and collagens I and III. We characterize for the first time an E2-regulated interaction of NPPA with ERα in cardiomyocytes, that may be crucial in physiological and/or pathological cardiac processes, thereby representing a potential therapeutic target.

  14. Dose-dependent effects of 17-ß-estradiol on pituitary thyrotropin content and secretion in vitro

    Directory of Open Access Journals (Sweden)

    Moreira R.M.


    Full Text Available We studied the basal and thyrotropin-releasing hormone (TRH (50 nM induced thyrotropin (TSH release in isolated hemipituitaries of ovariectomized rats treated with near-physiological or high doses of 17-ß-estradiol benzoate (EB; sc, daily for 10 days or with vehicle (untreated control rats, OVX. One group was sham-operated (normal control. The anterior pituitary glands were incubated in Krebs-Ringer bicarbonate medium, pH 7.4, at 37oC in an atmosphere of 95% O2/5% CO2. Medium and pituitary TSH was measured by specific RIA (NIDDK-RP-3. Ovariectomy induced a decrease (P<0.05 in basal TSH release (normal control = 44.1 ± 7.2; OVX = 14.7 ± 3.0 ng/ml and tended to reduce TRH-stimulated TSH release (normal control = 33.0 ± 8.1; OVX = 16.6 ± 2.4 ng/ml. The lowest dose of EB (0.7 µg/100 g body weight did not reverse this alteration, but markedly increased the pituitary TSH content (0.6 ± 0.06 µg/hemipituitary; P<0.05 above that of OVX (0.4 ± 0.03 µg/hemipituitary and normal rats (0.46 ± 0.03 µg/hemipituitary. The intermediate EB dose (1.4 µg/100 g body weight induced a nonsignificant tendency to a higher TSH response to TRH compared to OVX and a lower response compared to normal rats. Conversely, in the rats treated with the highest dose (14 µg/100 g body weight, serum 17-ß-estradiol was 17 times higher than normal, and the basal and TRH-stimulated TSH release, as well as the pituitary TSH content, was significantly (P<0.05 reduced compared to normal rats and tended to be even lower than the values observed for the vehicle-treated OVX group, suggesting an inhibitory effect of hyperestrogenism. In conclusion, while reinforcing the concept of a positive physiological regulatory role of estradiol on the TSH response to TRH and on the pituitary stores of the hormone, the present results suggest an inhibitory effect of high levels of estrogen on these responses

  15. Spraying effects on some physiological and behavioural traits of goats in a subtropical climate

    Directory of Open Access Journals (Sweden)

    Soner Cankaya


    Full Text Available Heat stress is one of the major factors adversely affecting animal welfare and thus economic benefits of farms. This study was designed to determine the effects of two different spraying methods on goats exposed to high air temperatures. Thirty goats were divided into three groups for the trial (sprayed once per day, OTS; sprayed twice per day, TTS; and non-sprayed, Controls. Respiration and pulse rates, rectal and surface temperatures (from head and udder skin were taken three times a day (08.00 - 09.00; 16.00 - 17.00 and 00.00 - 01.00 on hot summer days in July 2005 in a Mediterranean climate. Some behavioural aspects such as eating, ruminating, drinking, walking and resting, and daily feed and water consumption were regularly measured. Rectal temperatures, pulse and respiration rates, udder and head temperatures differed between the three groups. Rectal, head and udder temperatures and respiration and pulse rates increased at 16.00 relative to 08.00, and at 00.00 had returned to the same level as at 08.00. TTS goats showed smaller increases in all physiological measurements at 16.00 than the other groups. TTS goats spent more time than OTS and Control goats eating (P=0.002, ruminating (P=0.032 and walking (P=0.021, but less time drinking (P=0.041 and lying (P=0.001. TTS goats consumed more concentrate feed (P=0.001 and alfalfa hay (P=0.024 than the other two groups, whereas Control goats consumed more water (P=0.003 than the other groups. Ultimately, the spraying had positive effects on yearling goats for alleviating heat stress and improving animal welfare.

  16. Initial investigation of glucose metabolism in mouse brain using enriched 17 O-glucose and dynamic 17 O-MRS. (United States)

    Borowiak, Robert; Reichardt, Wilfried; Kurzhunov, Dmitry; Schuch, Christian; Leupold, Jochen; Krafft, Axel Joachim; Reisert, Marco; Lange, Thomas; Fischer, Elmar; Bock, Michael


    In this initial work, the in vivo degradation of 17 O-labeled glucose was studied during cellular glycolysis. To monitor cellular glucose metabolism, direct 17 O-magnetic resonance spectroscopy (MRS) was used in the mouse brain at 9.4 T. Non-localized spectra were acquired with a custom-built transmit/receive (Tx/Rx) two-turn surface coil and a free induction decay (FID) sequence with a short TR of 5.4 ms. The dynamics of labeled oxygen in the anomeric 1-OH and 6-CH 2 OH groups was detected using a Hankel-Lanczos singular value decomposition (HLSVD) algorithm for water suppression. Time-resolved 17 O-MRS (temporal resolution, 42/10.5 s) was performed in 10 anesthetized (1.25% isoflurane) mice after injection of a 2.2 M solution containing 2.5 mg/g body weight of differently labeled 17 O-glucose dissolved in 0.9% physiological saline. From a pharmacokinetic model fit of the H 2 17 O concentration-time course, a mean apparent cerebral metabolic rate of 17 O-labeled glucose in mouse brain of CMR Glc  = 0.07 ± 0.02 μmol/g/min was extracted, which is of the same order of magnitude as a literature value of 0.26 ± 0.06 μmol/g/min reported by 18 F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography (PET). In addition, we studied the chemical exchange kinetics of aqueous solutions of 17 O-labeled glucose at the C1 and C6 positions with dynamic 17 O-MRS. In conclusion, the results of the exchange and in vivo experiments demonstrate that the C6- 17 OH label in the 6-CH 2 OH group is transformed only glycolytically by the enzyme enolase into the metabolic end-product H 2 17 O, whereas C1- 17 OH ends up in water via direct hydrolysis as well as glycolysis. Therefore, dynamic 17 O-MRS of highly labeled 17 O-glucose could provide a valuable non-radioactive alternative to FDG PET in order to investigate glucose metabolism. Copyright © 2017 John Wiley & Sons, Ltd.

  17. 16th International Cryocooler Conference

    CERN Document Server

    Ross, Ronald G


    Cryocoolers 16 archives developments and performance measurements in the field of cryocoolers based on the contributions of leading international experts at the 16th International Cryocooler Conference that was held in Atlanta, Georgia, on May 17-20, 2010. The program of this conference consisted of 116 papers; of these, 89 are published here. Over the years the International Cryocoolers Conference has become the preeminent worldwide conference for the presentation of the latest developments and test experiences with cryocoolers. The typical applications of this technology include cooling space and terrestrial infrared focal plane arrays, space x-ray detectors, medical applications, and a growing number of high-temperature superconductor applications.

  18. Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity. (United States)

    Seals, Douglas R; Justice, Jamie N; LaRocca, Thomas J


    Most nations of the world are undergoing rapid and dramatic population ageing, which presents great socio-economic challenges, as well as opportunities, for individuals, families, governments and societies. The prevailing biomedical strategy for reducing the healthcare impact of population ageing has been 'compression of morbidity' and, more recently, to increase healthspan, both of which seek to extend the healthy period of life and delay the development of chronic diseases and disability until a brief period at the end of life. Indeed, a recently established field within biological ageing research, 'geroscience', is focused on healthspan extension. Superimposed on this background are new attitudes and demand for 'optimal longevity' - living long, but with good health and quality of life. A key obstacle to achieving optimal longevity is the progressive decline in physiological function that occurs with ageing, which causes functional limitations (e.g. reduced mobility) and increases the risk of chronic diseases, disability and mortality. Current efforts to increase healthspan centre on slowing the fundamental biological processes of ageing such as inflammation/oxidative stress, increased senescence, mitochondrial dysfunction, impaired proteostasis and reduced stress resistance. We propose that optimization of physiological function throughout the lifespan should be a major emphasis of any contemporary biomedical policy addressing global ageing. Effective strategies should delay, reduce in magnitude or abolish reductions in function with ageing (primary prevention) and/or improve function or slow further declines in older adults with already impaired function (secondary prevention). Healthy lifestyle practices featuring regular physical activity and ideal energy intake/diet composition represent first-line function-preserving strategies, with pharmacological agents, including existing and new pharmaceuticals and novel 'nutraceutical' compounds, serving as potential

  19. September 2017 Arizona thoracic society notes

    Directory of Open Access Journals (Sweden)

    Robbins RA


    Full Text Available No abstract available. Article truncated at 150 words. The September 2017 Arizona Thoracic Society meeting was held on Wednesday, September 27, 2017 at the HonorHealth Rehabilitation Hospital beginning at 6:30 PM. This was a dinner meeting with case presentations. There were 16 in attendance representing the pulmonary, critical care, sleep, and radiology communities. There was a discussion of the Tobacco 21 bill which had been introduced the last session in the Arizona State Legislature. Since it seems likely that the bill will be reintroduced, the Arizona Thoracic Society will support the bill in the future. Dr. Rick Robbins announced that the SWJPCC has applied to be included in PubMed. In addition, Dr. Robbins was assigned the task of tracking down the campaign contributions to congressional members from the tobacco PAC before the next election. There were 7 case presentations: 1.\tAshley L. Garrett, MD, pulmonary fellow at Mayo, presented an elderly man with insulin-dependent diabetes who felt he …

  20. Stable isotope tracers and exercise physiology: past, present and future. (United States)

    Wilkinson, Daniel J; Brook, Matthew S; Smith, Kenneth; Atherton, Philip J


    Stable isotope tracers have been invaluable assets in physiological research for over 80 years. The application of substrate-specific stable isotope tracers has permitted exquisite insight into amino acid, fatty-acid and carbohydrate metabolic regulation (i.e. incorporation, flux, and oxidation, in a tissue-specific and whole-body fashion) in health, disease and response to acute and chronic exercise. Yet, despite many breakthroughs, there are limitations to 'substrate-specific' stable isotope tracers, which limit physiological insight, e.g. the need for intravenous infusions and restriction to short-term studies (hours) in controlled laboratory settings. In recent years significant interest has developed in alternative stable isotope tracer techniques that overcome these limitations, in particular deuterium oxide (D 2 O or heavy water). The unique properties of this tracer mean that through oral administration, the turnover and flux through a number of different substrates (muscle proteins, lipids, glucose, DNA (satellite cells)) can be monitored simultaneously and flexibly (hours/weeks/months) without the need for restrictive experimental control. This makes it uniquely suited for the study of 'real world' human exercise physiology (amongst many other applications). Moreover, using D 2 O permits evaluation of turnover of plasma and muscle proteins (e.g. dynamic proteomics) in addition to metabolomics (e.g. fluxomics) to seek molecular underpinnings, e.g. of exercise adaptation. Here, we provide insight into the role of stable isotope tracers, from substrate-specific to novel D 2 O approaches, in facilitating our understanding of metabolism. Further novel potential applications of stable isotope tracers are also discussed in the context of integration with the snowballing field of 'omic' technologies. © 2016 The Authors. The Journal of Physiology © 2016 The Physiological Society.

  1. Hydropower and Environmental Sustainability - HydroES 2016 Report on the Conference held by SHF in Grenoble on March 16-17, 2016

    International Nuclear Information System (INIS)

    Barillier, Agnes; Caignaert, Guy; Gouraud, Veronique; Ramos, Maria-Helena; Roult, Didier; Viollet, Pierre-Louis


    Hydropower is an important source of renewable energy for electrical production in Europe and throughout the world. Being flexible and allowing energy storage, it also facilitates the development of intermittent energy in electricity systems. The development, operation and maintenance of hydropower production are closely related to growing concerns on environment sustainability, climate change mitigation and meeting societal needs for energy. Reliable and efficient hydropower facilities can improve hydropower performance and the environmental acceptability of new projects when they are also planned to protect the environment in which they operate. This document presents a synthesis report of the international conference HydroES 2016 - Hydropower and Environmental Sustainability, organized by SHF and hosted by INP ENSE3, in Grenoble, on 16-17 March 2016. It shows that the scientific community and the hydropower industry are committed to assessing environment and social impacts of hydropower and are proactive towards a sustainable future. (authors)

  2. Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years

    DEFF Research Database (Denmark)

    Buchvald, Frederik; Baraldi, Eugenio; Carraro, Silvia


    to almost 100% from the age of 10 years. The repeatability of 3 approved measurements was 1.6 ppb (95% CI, 1.49-1.64 ppb). CONCLUSION: FE NO in healthy children is below 15 to 25 ppb depending on age and self-reported atopy. Measurement of FE NO by NIOX is simple and safe and has a good repeatability...... NO was measured in healthy subjects of 4 to 17 years according to American Thoracic Society guidelines (single breath online, exhalation flow 50 mL/s) with a chemiluminescence analyzer (NIOX Exhaled Nitric Oxide Monitoring System, Aerocrine, Sweden) in 3 European and 2 US centers. Each child performed 3...... NO in 405 children was 9.7 ppb, and the upper 95% confidence limit was 25.2 ppb. FE NO increased significantly with age, and higher FE NO was seen in children with self-reported rhinitis/conjunctivitis or hay fever. The success rate was age-dependent and improved from 40% in the children 4 years old...

  3. First trimester fetal physiologic midgut herniation: Transvaginal sonographic findings

    International Nuclear Information System (INIS)

    Kwon, Tae Hee; Park, Yong Hyun


    To evaluate the sonographic features and appearance time of the physiologic midgut herniation early in pregnancy. Sonograms of 87 features ranging from 7 to 13 weeks were obtained over a 2-month period. The presence or absence, the size and echogenecity of the physiologic midgut herniation were evaluate on each examination. Disappearance of the midgut herniation was confirmed on follow-up sonogram at 13-20 weeks, 3-12 weeks after the first sonogram. The results were analyzed in terms of appearance or disappearance time of midgut herniation. In all cases of physiologic midgut herination, an echogenic mass measuring 0.4-0.7 cm wa demonstrated within the base of the umbilical cord at its insertion into the fetal abdomen. This herniation was detected in 3/6 cases (50%) at 8 weeks, in 15/16 cases (94%) at 9 weeks, in 22/24 cases (92%) at 10 weeks and in 12/27 cases (44%) at 11 weeks gestation. None of the features studied at 7 weeks and 12 weeks had a midgut herniation. Sonographic findings of a 0.4-0.7 cm sized echogenic mass within the base of the umbilical cord which appears from 8 weeks to 12 weeks pregnancy represent physiologic midgut herniation in early pregnancy and should not be confused with pathologic ventral wall defected such as omphalocele or gastroschisis.

  4. First trimester fetal physiologic midgut herniation: Transvaginal sonographic findings

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Tae Hee; Park, Yong Hyun [CHA General Hospital. Pochon College of Medicine, Seoul (Korea, Republic of)


    To evaluate the sonographic features and appearance time of the physiologic midgut herniation early in pregnancy. Sonograms of 87 features ranging from 7 to 13 weeks were obtained over a 2-month period. The presence or absence, the size and echogenecity of the physiologic midgut herniation were evaluate on each examination. Disappearance of the midgut herniation was confirmed on follow-up sonogram at 13-20 weeks, 3-12 weeks after the first sonogram. The results were analyzed in terms of appearance or disappearance time of midgut herniation. In all cases of physiologic midgut herination, an echogenic mass measuring 0.4-0.7 cm wa demonstrated within the base of the umbilical cord at its insertion into the fetal abdomen. This herniation was detected in 3/6 cases (50%) at 8 weeks, in 15/16 cases (94%) at 9 weeks, in 22/24 cases (92%) at 10 weeks and in 12/27 cases (44%) at 11 weeks gestation. None of the features studied at 7 weeks and 12 weeks had a midgut herniation. Sonographic findings of a 0.4-0.7 cm sized echogenic mass within the base of the umbilical cord which appears from 8 weeks to 12 weeks pregnancy represent physiologic midgut herniation in early pregnancy and should not be confused with pathologic ventral wall defected such as omphalocele or gastroschisis.

  5. Confined zone dispersion flue gas desulfurization demonstration. Quarterly report No. 8, August 17, 1992--November 16, 1992

    Energy Technology Data Exchange (ETDEWEB)


    The CZD process involves injecting a finely atomized slurry of reactive lime into the flue gas duct work of a coal-fired utility boiler. The principle of the confined zone is to form a wet zone of slurry droplets in the middle of the duct confined in an envelope of hot gas between the wet zone and the duct walls. The lime slurry reacts with part of the SO{sub 2} in the gas, and the reaction products dry to form solid particles. A solids collector, typically an electrostatic precipitator (ESP) downstream from the point of injection, captures the reaction products along with the fly ash entrained in the flue gas. The goal of this demonstration is to prove the technical and economic feasibility of the CZD technology on a commercial scale. The process is expected to achieve 50% SO{sub 2} removal at lower capital and O&M costs than other systems. To achieve its objectives, the project is divided into the following three phases: Phase 1: Design and Permitting, Phase 2: Construction and Start-up, Phase 3: Operation and Disposition. Phase 1 activities were completed on January 31, 1991. Phase 2 activities were essentially concluded on July 31, 1991, and Phase 3a, Parametric Testing, was initiated on July 1, 1991. This Quarterly Technical Progress Report covers Phase 3b activities from August 17, 1992 through November 16, 1992.

  6. Physiological Effects of Touching Wood

    Directory of Open Access Journals (Sweden)

    Harumi Ikei


    Full Text Available This study aimed to clarify the physiological effects of touching wood with the palm, in comparison with touching other materials on brain activity and autonomic nervous activity. Eighteen female university students (mean age, 21.7  ±  1.6 years participated in the study. As an indicator of brain activity, oxyhemoglobin (oxy-Hb concentrations were measured in the left/right prefrontal cortex using near-infrared time-resolved spectroscopy. Heart rate variability (HRV was used as an indicator of autonomic nervous activity. The high-frequency (HF component of HRV, which reflected parasympathetic nervous activity, and the low-frequency (LF/HF ratio, which reflected sympathetic nervous activity, were measured. Plates of uncoated white oak, marble, tile, and stainless steel were used as tactile stimuli. After sitting at rest with their eyes closed, participants touched the materials for 90 s. As a result, tactile stimulation with white oak significantly (1 decreased the oxy-Hb concentration in the left/right prefrontal cortex relative to marble, tile, and stainless steel and (2 increased ln(HF-reflected parasympathetic nervous activity relative to marble and stainless steel. In conclusion, our study revealed that touching wood with the palm calms prefrontal cortex activity and induces parasympathetic nervous activity more than other materials, thereby inducing physiological relaxation.

  7. Quantitative Circulatory Physiology: an integrative mathematical model of human physiology for medical education. (United States)

    Abram, Sean R; Hodnett, Benjamin L; Summers, Richard L; Coleman, Thomas G; Hester, Robert L


    We have developed Quantitative Circulatory Physiology (QCP), a mathematical model of integrative human physiology containing over 4,000 variables of biological interactions. This model provides a teaching environment that mimics clinical problems encountered in the practice of medicine. The model structure is based on documented physiological responses within peer-reviewed literature and serves as a dynamic compendium of physiological knowledge. The model is solved using a desktop, Windows-based program, allowing students to calculate time-dependent solutions and interactively alter over 750 parameters that modify physiological function. The model can be used to understand proposed mechanisms of physiological function and the interactions among physiological variables that may not be otherwise intuitively evident. In addition to open-ended or unstructured simulations, we have developed 30 physiological simulations, including heart failure, anemia, diabetes, and hemorrhage. Additional stimulations include 29 patients in which students are challenged to diagnose the pathophysiology based on their understanding of integrative physiology. In summary, QCP allows students to examine, integrate, and understand a host of physiological factors without causing harm to patients. This model is available as a free download for Windows computers at

  8. Division 45: The Society for the Psychological Study of Ethnic Minority Issues (United States)

    Morales, Eduardo; Lau, Michael Y.; Ballesteros, Andrea


    This article covers the Society for the Psychological Study of Ethnic Minority Psychology, Division 45 of the American Psychological Association (APA) in understanding the relationship of ethnic minority psychological associations with Division 17. A brief history is provided, followed by current status and resources, connections to counseling…

  9. Effectiveness of inquiry-based learning in an undergraduate exercise physiology course. (United States)

    Nybo, Lars; May, Michael


    The present study was conducted to investigate the effects of changing a laboratory physiology course for undergraduate students from a traditional step-by-step guided structure to an inquiry-based approach. With this aim in mind, quantitative and qualitative evaluations of learning outcomes (individual subject-specific tests and group interviews) were performed for a laboratory course in cardiorespiratory exercise physiology that was conducted in one year with a traditional step-by-step guided manual (traditional course) and the next year completed with an inquiry-based structure (I-based course). The I-based course was a guided inquiry course where students had to design the experimental protocol and conduct their own study on the basis of certain predefined criteria (i.e., they should evaluate respiratory responses to submaximal and maximal exercise and provide indirect and direct measures of aerobic exercise capacity). The results indicated that the overall time spent on the experimental course as well as self-evaluated learning outcomes were similar across groups. However, students in the I-based course used more time in preparation (102 ± 5 min) than students in the traditional course (42 ± 3 min, P traditional course. Furthermore, students in the I-based course achieved a higher (P traditional course (31 ± 4%). Although students were unfamiliar with cardiorespiratory exercise physiology and the experimental methods before the course, it appears that an inquiry-based approach rather than one that provides students with step-by-step instructions may benefit learning outcomes in a laboratory physiology course. Copyright © 2015 The American Physiological Society.

  10. Determination of maximum physiologic thyroid uptake and correlation with 24-hour RAI uptake value

    International Nuclear Information System (INIS)

    Duldulao, M.; Obaldo, J.


    Full text: In hyperthyroid patients, thyroid uptake values are overestimated, sometimes approaching or exceeding 100%. This is physiologically and mathematically impossible. This study was undertaken to determine the maximum physiologic thyroid uptake value through a proposed simple method using a gamma camera. Methodology: Twenty-two patients (17 females and 5 males), with ages ranging from 19-61 y/o (mean age ± SD; 41 ± 12), with 24-hour uptake value of >50%, clinically hyperthyroid and referred for subsequent radioactive iodine therapy were studied. The computed maximum physiologic thyroid uptake was compared with the 24-hour uptake using the paired Student t-test and evaluated using linear regression analysis. Results: The computed physiologic uptake correlated poorly with the 24-hour uptake value. However, in the male subgroup, there was no statistically significant difference between the two (p=0.77). Linear regression analysis gives the following relationship: physiologic uptake (%) = 77.76 - 0.284 (24-hour RAI uptake value). Conclusion: Provided that proper regions of interest are applied with correct attenuation and background subtraction, determination of physiologic thyroid uptake may be obtained using the proposed method. This simple method may be useful prior to I-131 therapy for hyperthyroidism especially when a single uptake determination is performed. (author)

  11. Using stimulation of the diving reflex in humans to teach integrative physiology. (United States)

    Choate, Julia K; Denton, Kate M; Evans, Roger G; Hodgson, Yvonne


    During underwater submersion, the body responds by conserving O2 and prioritizing blood flow to the brain and heart. These physiological adjustments, which involve the nervous, cardiovascular, and respiratory systems, are known as the diving response and provide an ideal example of integrative physiology. The diving reflex can be stimulated in the practical laboratory setting using breath holding and facial immersion in water. Our undergraduate physiology students complete a laboratory class in which they investigate the effects of stimulating the diving reflex on cardiovascular variables, which are recorded and calculated with a Finapres finger cuff. These variables include heart rate, cardiac output, stroke volume, total peripheral resistance, and arterial pressures (mean, diastolic, and systolic). Components of the diving reflex are stimulated by 1) facial immersion in cold water (15°C), 2) breathing with a snorkel in cold water (15°C), 3) facial immersion in warm water (30°C), and 4) breath holding in air. Statistical analysis of the data generated for each of these four maneuvers allows the students to consider the factors that contribute to the diving response, such as the temperature of the water and the location of the sensory receptors that initiate the response. In addition to providing specific details about the equipment, protocols, and learning outcomes, this report describes how we assess this practical exercise and summarizes some common student misunderstandings of the essential physiological concepts underlying the diving response. Copyright © 2014 The American Physiological Society.

  12. Mass Society

    DEFF Research Database (Denmark)

    Borch, Christian


    the negative features usually ascribed by late nineteenth-century crowd psychology to spontaneous crowds, and attributes these to the entire social fabric. However, in contrast to crowd psychology, theorists of mass society often place greater emphasis on how capitalism, technological advances, or demographic......Mass society is a societal diagnosis that emphasizes – usually in a pejorative, modernity critical manner – a series of traits allegedly associated with modern society, such as the leveling of individuality, moral decay, alienation, and isolation. As such, the notion of mass society generalizes...... developments condition such negative features, and some theorists argue that mass society produces a propensity to totalitarianism. Discussions of mass society culminated in the early and mid-twentieth century....

  13. Sixty years of the Interamerican Society of Psychology (SIP): origins and development. (United States)

    Gallegos, Miguel


    This paper presents a historical overview of the Interamerican Society of Psychology, which was founded on December 17, 1951, in Mexico City. Firstly, the historical circumstances of the foundation period are presented, as well as the people who made this organization possible, and the state of psychology on the American continent at that time. Secondly, the most important activities that the Interamerican Society of Psychology has developed during its 60 years are mentioned, such as the publication of books and scientific journals, the creation of several task forces and the Interamerican Congresses of Psychology. Basically, the purpose of this paper is to review the history of the Interamerican Society of Psychology through the recovery and use of various documentary sources.

  14. Enhanced radiative Auger emission from lithiumlike 20Ca17+

    International Nuclear Information System (INIS)

    Bernstein, E.M.; Clark, M.W.; Tanis, J.A.; Graham, W.G.; Morgan, T.J.; Stoeckli, M.P.; Berkner, K.H.; Schlachter, A.S.; Stearns, J.W.


    Radiative Auger emission (RAE) from lithiumlike 20 Ca 17+ projectiles excited in collisions with He has been measured. The intensity of RAE photons relative to K α X-ray emission is enhanced by a factor of 10-17 compared with theoretical calculations for ions with few electron vacancies. The enhancement of RAE for Ca 17+ is consistent with the results reported previously for lithiumlike 16 S 13+ and 23 V 20+ and indicates a systematic dependence on Z. Both the enhancement and the relative RAE transition rate increase with Z. (orig.)

  15. New Models explaining regional Evolution in Europe. Contributions to an international conference in honour of Professor J.H.P. Paelinck Tinbergen Institute, Rotterdam, June 16-17, 1995. Introduction

    Directory of Open Access Journals (Sweden)

    Pierre-Henri Derycke


    Full Text Available At the end of the academic year 1994-95, Professor J.Paelinck left the chair of spatial theory he occupied at the Erasmus University in Rotterdam for several decades. On this occasion, his disciples – in particular, Hans KUIPER and Riccardo GIRARDI - and numerous colleagues and friends organised on June 16-17 an International Conference held at the Tinbergen Institute. About forty spatial analysts and regional science specialists, belonging to 10 different countries, were present to this even...

  16. Cost consideration in the clinical guidance documents of physician specialty societies in the United States. (United States)

    Schwartz, Jennifer A T; Pearson, Steven D


    Despite increasing concerns regarding the cost of health care, the consideration of costs in the development of clinical guidance documents by physician specialty societies has received little analysis. To evaluate the approach to consideration of cost in publicly available clinical guidance documents and methodological statements produced between 2008 and 2012 by the 30 largest US physician specialty societies. Qualitative document review. Whether costs are considered in clinical guidance development, mechanism of cost consideration, and the way that cost issues were used in support of specific clinical practice recommendations. Methodological statements for clinical guidance documents indicated that 17 of 30 physician societies (57%) explicitly integrated costs, 4 (13%) implicitly considered costs, 3 (10%) intentionally excluded costs, and 6 (20%) made no mention. Of the 17 societies that explicitly integrated costs, 9 (53%) consistently used a formal system in which the strength of recommendation was influenced in part by costs, whereas 8 (47%) were inconsistent in their approach or failed to mention the exact mechanism for considering costs. Among the 138 specific recommendations in these guidance documents that included cost as part of the rationale, the most common form of recommendation (50 [36%]) encouraged the use of a specific medical service because of equal effectiveness and lower cost. Slightly more than half of the largest US physician societies explicitly consider costs in developing their clinical guidance documents; among these, approximately half use an explicit mechanism for integrating costs into the strength of recommendations. Many societies remain vague in their approach. Physician specialty societies should demonstrate greater transparency and rigor in their approach to cost consideration in documents meant to influence care decisions.

  17. IFRS 16 “Leases” – consequences on the financial statements and financial indicators

    Directory of Open Access Journals (Sweden)

    Marian SACARIN


    Full Text Available In January 2016, the International Accounting Standards Board (IASB issued IFRS 16 “Leases”, which will replace the current standard IAS 17 “Leases”. IFRS 16, whose application is mandatory for annual periods beginning on or after January 2019, sets out new rules for the recognition and measurement of leases, leading to a change of value for the elements recognized in the financial statements, as well as for the financial indicators calculated based on these. The purpose of this article is to present, based on a comparative analysis of IFRS 16 and IAS 17, the main consequences that the application of IFRS 16 will arise, in respect of the financial statements and the financial indicators determined based on the information provided by these.

  18. Human colorectal mucosal microbiota correlates with its host niche physiology revealed by endomicroscopy. (United States)

    Wang, Ai-Hua; Li, Ming; Li, Chang-Qing; Kou, Guan-Jun; Zuo, Xiu-Li; Li, Yan-Qing


    The human gut microbiota plays a pivotal role in the maintenance of health, but how the microbiota interacts with the host at the colorectal mucosa is poorly understood. We proposed that confocal laser endomicroscopy (CLE) might help to untangle this relationship by providing in vivo physiological information of the mucosa. We used CLE to evaluate the in vivo physiology of human colorectal mucosa, and the mucosal microbiota was quantified using 16 s rDNA pyrosequencing. The human mucosal microbiota agglomerated to three major clusters dominated by Prevotella, Bacteroides and Lactococcus. The mucosal microbiota clusters did not significantly correlate with the disease status or biopsy sites but closely correlated with the mucosal niche physiology, which was non-invasively revealed by CLE. Inflammation tilted two subnetworks within the mucosal microbiota. Infiltration of inflammatory cells significantly correlated with multiple components in the predicted metagenome, such as the VirD2 component of the type IV secretory pathway. Our data suggest that a close correlation exists between the mucosal microbiota and the colorectal mucosal physiology, and CLE is a clinically available tool that can be used to facilitate the study of the in vivo correlation between colorectal mucosal physiology and the mucosal microbiota.

  19. Sexual disruption in zebrafish (Danio rerio) exposed to mixtures of 17α-ethinylestradiol and 17β-trenbolone

    DEFF Research Database (Denmark)

    Örn, Stefan; Holbech, Henrik; Norrgren, Leif


    was to evaluate feminization and masculinization effects in zebrafish (Danio rerio) exposed to combinations of two synthetic steroid hormones detected in environmental waters: the androgen 17β-trenbolone (Tb) and the oestrogen 17α-ethinylestradiol (EE2). Juvenile zebrafish were exposed between days 20 and 60 post......Environmental estrogens and androgens can be present simultaneously in aquatic environments and thereby interact to disturb multiple physiological systems in organisms. Studies on interaction effects in fish of androgenic and estrogenic chemicals are limited. Therefore, the aim of the present study......-hatch to different binary mixtures of Tb (1, 10, and 50 ng/L) and EE2 (2 and 5 ng/L). The endpoints studied were whole-body homogenate vitellogenin concentration at 40 days post-hatch, and sex ratio including gonad maturation at 60 days post-hatch. The feminizing potency of 5 ng/L of EE2, alone as well...

  20. Genetic diversification of chemokine CXCL16 and its receptor CXCR6 in primates. (United States)

    Xu, Feifei; He, Dan; Liu, Jiabin; Ni, Qingyong; Lyu, Yongqing; Xiong, Shiqiu; Li, Yan


    Chemokine CXCL16 and its receptor CXCR6 are associated with a series of physiological and pathological processes in cooperative and stand-alone fashions. To shed insight into their versatile nature, we studied genetic variations of CXCL16 and CXCR6 in primates. Evolutionary analyses revealed that these genes underwent a similar evolutionary fate. Both genes experienced adaptive diversification with the phylogenetic division of cercopithecoids (Old World monkeys) and hominoids (humans, great apes, and gibbons) from their common ancestor. In contrast, they were conserved in the periods preceding and following the dividing process. In terms of the adaptive diversification between cercopithecoids and hominoids, the adaptive genetic changes have occurred in the mucin-like and chemokine domains of CXCL16 and the N-terminus and transmembrane helixes of CXCR6. In combination with currently available structural and functional information for CXCL16 and CXCR6, the parallels between the evolutionary footprints and the co-occurrence of adaptive diversification at some evolutionary stage suggest that interplay could exist between the diversification-related amino acid sites, or between the domains on which the identified sites are located, in physiological processes such as chemotaxis and/or cell adhesion. Copyright © 2018 Elsevier Ltd. All rights reserved.

  1. Crystal structure of 16-ferrocenylmethyl-3β-hydroxyestra-1,3,5(10-trien-17-one: a potential chemotherapeutic drug

    Directory of Open Access Journals (Sweden)

    José A. Carmona-Negrón


    Full Text Available A new ferrocene complex, 16-ferrocenylmethyl-3β-hydroxyestra-1,3,5(10-trien-17-one dimethyl sulfoxide monosolvate, [Fe(C5H5(C24H27O2]·C2H6OS, has been synthesized and structurally characterized by single-crystal X-ray diffraction techniques. The molecule crystallizes in the space group P21 with one molecule of dimethyl sulfoxide. A hydrogen bond links the phenol group and the dimethyl sulfoxide O atom, with an O...O distance of 2.655 (5 Å. The ferrocene group is positioned in the β face of the estrone moiety, with an O—C—C—C torsion angle of 44.1 (5°, and the carbonyl bond length of the hormone moiety is 1.216 (5 Å, typical of a C=O double bond. The average Fe—C bond length of the substituted Cp ring [Fe—C(Cp*] is similar to that of the unsubstituted one [Fe—C(Cp], i.e. 2.048 (3 versus 2.040 (12 Å. The structure of the complex is compared with those of estrone and ethoxymethylestrone.

  2. Foundations of Intonational Meaning: Anatomical and Physiological Factors. (United States)

    Gussenhoven, Carlos


    Like non-verbal communication, paralinguistic communication is rooted in anatomical and physiological factors. Paralinguistic form-meaning relations arise from the way these affect speech production, with some fine-tuning by the cultural and linguistic context. The effects have been classified as "biological codes," following the terminological lead of John Ohala's Frequency Code. Intonational morphemes, though arguably non-arbitrary in principle, are in fact heavily biased toward these paralinguistic meanings. Paralinguistic and linguistic meanings for four biological codes are illustrated. In addition to the Frequency Code, the Effort Code, and the Respiratory Code, the Sirenic Code is introduced here, which is based on the use of whispery phonation, widely seen as being responsible for the signaling and perception of feminine attractiveness and sometimes used to express interrogativity in language. In the context of the evolution of language, the relations between physiological conditions and the resulting paralinguistic and linguistic meanings will need to be clarified. Copyright © 2016 The Authors. Topics in Cognitive Science published by Wiley Periodicals, Inc. on behalf of Cognitive Science Society.

  3. Exploring student preferences with a Q-sort: the development of an individualized renal physiology curriculum. (United States)

    Roberts, John K; Hargett, Charles W; Nagler, Alisa; Jakoi, Emma; Lehrich, Ruediger W


    Medical education reform is underway, but the optimal course for change has yet to be seen. While planning for the redesign of a renal physiology course at the Duke School of Medicine, the authors used a Q-sort survey to assess students' attitudes and learning preferences to inform curricular change. The authors invited first-year medical students at the Duke School of Medicine to take a Q-sort survey on the first day of renal physiology. Students prioritized statements related to their understanding of renal physiology, learning preferences, preferred course characteristics, perceived clinical relevance of renal physiology, and interest in nephrology as a career. By-person factor analysis was performed using the centroid method. Three dominant factors were strongly defined by learning preferences: "readers" prefer using notes, a textbook, and avoid lectures; "social-auditory learners" prefer attending lectures, interactivity, and working with peers; and "visual learners" prefer studying images, diagrams, and viewing materials online. A smaller, fourth factor represented a small group of students with a strong predisposition against renal physiology and nephrology. In conclusion, the Q-sort survey identified and then described in detail the dominant viewpoints of our students. Learning style preferences better classified first-year students rather than any of the other domains. A more individualized curriculum would simultaneously cater to the different types of learners in the classroom. Copyright © 2015 The American Physiological Society.

  4. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Epidemiology”

    Directory of Open Access Journals (Sweden)

    Various Authors


    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Epidemiology”ABS 1. A PERFORMANCE INDICATOR FOR THE PROLONGATION OF GESTATIONAL AGE • N. LackABS 2. LATE PRETERM NEONATES AND CAUSES OF ADMISSION TO THE NICU • S. Arayici, G. Kadioglu Simsek, B. Say, E. Alyamac Dizdar, N. Uras, F.E. Canpolat, S.S. OguzABS 3. INCIDENCE AND OUTCOMES OF METABOLIC DISORDERS IN VERY PRETERM INFANTS • O. Dobush, D. Dobryanskyy, Z. Salabay, O. Detsyk, O. Novikova, Y. KuzminovABS 4. MATERNAL FACTORS INFLUENCE INFANT’S VITAMIN D STATUS • H. Hauta-alus, E. Holmlund-Suila, M. Enlund-Cerullo, J. Rosendahl, S. Valkama, O. Helve, H-M. Surcel, O. Mäkitie, S. Andersson, H. ViljakainenABS 5. THE HIGH PREVALENCE OF VITAMIN D DEFICIENCY IN A LARGE NUMBER OF PREGNANT WOMEN AND RELATED FACTORS IN ANKARA, TURKEY • G. Kadioglu Simsek, F. E. Canpolat, S. Arayici, G. Kanmaz Kutman, H.I. Yakut, Ö. Moraloğlu, B. ÖzkanABS 6. SNAPPE-II: A VALUABLE PREDICTOR OF ADVERSE OUTCOMES IN PREMATURITY • P. Costa-Reis, R. Monteiro, M. Abrantes, P. Costa, A. Graça, C. MonizABS 7. THE ASSOCIATION BETWEEN MATERNAL AND FETAL 25OHD AND INFANT SIZE AND ADIPOSITY AT BIRTH, 6 MONTHS AND 2 YEARS OF AGE • M

  5. Digital Denmark: From Information Society to Network Society

    DEFF Research Database (Denmark)

    Henten, Anders; Falch, Morten


    for a welfare society. However, globalisation and the spreading use of new information and communication technologies and services challenge this position. This article examines Denmark's performance in implementing its IS 2000 plans, the background to the Digital Denmark report, and its implications......The Danish Government recently issued a new policy report, Digital Denmark, on the "conversion to a network society", as a successor to its Information Society 2000 report (1994). This is part of a new round of information society policy vision statements that are, or will be forthcoming from...... national governments everywhere. Denmark provides an interesting case study because it ranks high in the benchmark indicators of information network society developments. This position has been obtained largely by public sector initiatives and without erosion of the highly reputed Scandinavian model...

  6. Anti-tumor effect of 131I labeled 17-allylamino-17-demethoxygeldanamycin on human non-small cell lung cancer in xenograft-bearing nude mice

    International Nuclear Information System (INIS)

    Sun Jin; Liu Lu; Zhu Xiaoli; Chen Daozhen; Gao Wen; Jiang Xinyu; Huang Ying


    Objective: 17-allylamino-17-demethoxygeldanamycin (17-AAG) has been developed as a novel heat shock protein 90 (HSP90) inhibitor being used in clinical trials. HSP90 is known as a molecular target for tumor therapy. The goal of this study was to investigate the inhibitive effects of 131 I labeled 17-AAG on human non-small cell lung cancer in xenograft-bearing nude mice. Methods: 17-AAG was labeled with 131 I. Twenty-eight BALB/c nude mice bearing H460 human non-small cell lung carcinoma tumor xenograft were randomly divided into seven groups, one control group and six treatment groups according to the route of administration (via tail vein injection or intratumoral injection) and the doses of injected radio-activity (5.5 MBq x 2 with 8 d interval, 11.0 MBq and 5.5 MBq). Two additional mice were treated with intratumoral injection of Na 131 I solution that was served as seintigraphic imaging controls. In each group two mice underwent scintigraphy at 2 h, 6 h, 24 h, 2 d, 3 d, 7 d, 10 d and 16 d. After 16 d the tumor inhibition rate was calculated. Then all of the mice were sacrificed and the tumor tissues were obtained for histological examination and immunohistochemical assay. Results: Persistent accumulation of 131 I-17-AAG in the tumors was seen on seintigraphic images. Tumor inhibiting effect was demonstrated in all treatment groups with varying degrees. The highest tumor inhibition rate (86.77 ± 4.57)% was shown in the group with interval intratumoral injection (5.5 MBq x 2). There was no significant difference of tumor inhibition rates between 5.5 MBq x 2 group (via tail vein injection) and 11.0 MBq group( via tail vein injection, q=1.67, P>0.05). While among the other treatment groups, there was significant difference in tumor inhibition rates( q=3.16-24.34, all P 131 I-17-AAG may effectively inhibit the tumor growth and expression of HSP90α antigen expression in non-small cell lung cancer bearing nude mice. The more prominent anti-tumor effect may be

  7. Proceedings of the Korean Society Nuclear Medicine Autumn Meeting 2002

    International Nuclear Information System (INIS)


    This proceedings contains articles of 2002 autumn meeting of the Korean Society Nuclear Medicine. It was held on November 15-16, 2002 in Seoul, Korea. This proceedings is comprised of 5 sessions. The subject titles of session are as follows: Cancer, Physics of nuclear medicine, Neurology, Radiopharmacy and biology, General nuclear medicine. (Yi, J. H.)

  8. The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer

    DEFF Research Database (Denmark)

    Hansen, Lasse Tengbjerg; Lundin, Cecilia; Spang-Thomsen, Mogens


    Etoposide (VP16) is a potent inducer of DNA double-strand breaks (DSBs) and is efficiently used in small cell lung cancer (SCLC) therapy. However, acquired VP16 resistance remains an important barrier to effective treatment. To understand the underlying mechanisms for VP16 resistance in SCLC, we...... investigated DSB repair and cellular VP16 sensitivity of SCLC cells. VP16 sensitivity and RAD51, DNA-PK(cs), topoisomerase IIalpha and P-glycoprotein protein levels were determined in 17 SCLC cell lines. In order to unravel the role of RAD51 in VP16 resistance, we cloned the human RAD51 gene, transfected SCLC...... cells with RAD51 sense or antisense constructs and measured the VP16 resistance. Finally, we measured VP16-induced DSBs in the 17 SCLC cell lines. Two cell lines exhibited a multidrug-resistant phenotype. In the other SCLC cell lines, the cellular VP16 resistance was positively correlated with the RAD51...

  9. Seventh workshop on seedling physiology and growth problems in oak plantings (abstracts); 1998 September 27-29; South Lake Tahoe, CA. (United States)

    D.D. McCreary; J.G. Isebrands


    Research results and ongoing research activities in field performance of planted trees, seedling propagation, physiology, genetics, acorn germination, and natural regeneration for oaks are described in 17 abstracts.

  10. Brain angiotensin-(1-7)/Mas axis: A new target to reduce the cardiovascular risk to emotional stress. (United States)

    Fontes, Marco Antônio Peliky; Martins Lima, Augusto; Santos, Robson Augusto Souza dos


    Emotional stress is now considered a risk factor for several diseases including cardiac arrhythmias and hypertension. It is well known that the activation of neuroendocrine and autonomic mechanisms features the response to emotional stress. However, its link to cardiovascular diseases and the regulatory mechanisms involved remain to be further comprehended. The renin-angiotensin system (RAS) plays an important role in homeostasis on all body systems. Specifically in the brain, the RAS regulates a number of physiological aspects. Recent data indicate that the activation of angiotensin-converting enzyme/angiotensin II/AT1 receptor axis facilitates the emotional stress responses. On the other hand, growing evidence indicates that its counterregulatory axis, the angiotensin-converting enzyme 2 (ACE2)/(Ang)iotensin-(1-7)/Mas axis, reduces anxiety and attenuates the physiological responses to emotional stress. The present review focuses on angiotensin-(1-7)/Mas axis as a promising target to attenuate the physiological response to emotional stress reducing the risk of cardiovascular diseases. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. The effects of 16 weeks of intensive cycling training on seminal oxidants and antioxidants in male road cyclists. (United States)

    Maleki, Behzad Hajizadeh; Tartibian, Bakhtyar; Vaamonde, Diana


    To examine the effects of 16 weeks of intensive cycling training on seminal reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD), catalase, and total antioxidant capacity (TAC) in male road cyclists. Repeated measures design. The Exercise Physiology Laboratory of the Urmia University. Twenty-four healthy nonprofessional male road cyclists (aged 17-26 years) participated in this study. All subjects participated in 16 weeks of intensive cycling training. The semen samples were collected, respectively, at baseline (T1), immediately (T2), 12 (T3), and 24 (T4) hours after the last training session in week 8; immediately (T5), 12 (T6), and 24 (T7) hours after the last training session in week 16; and 7 (T8) and 30 (T9) days after the last training session in week 16. Total antioxidant capacity and SOD were measured by colorimetric assay. The levels of ROS were measured by a chemiluminescence assay. Malondialdehyde levels were measured by thiobarbituric acid reactive substance assay. Catalase was measured by monitoring the initial rate of disappearance of hydrogen peroxide (initial concentration 10 mM) at 240 nm. The levels of seminal ROS and MDA increased (P < 0.008) and remained high after 30 days of recovery. The levels of seminal SOD, catalase, and TAC decreased (P < 0.008) and remained low after 30 days of recovery (P < 0.008). Sixteen weeks of intensive cycling training may have deleterious consequences for spermatozoa and hence may affect sperm healthy parameters in male cyclists.

  12. 81st Annual Meeting of the Psychometric Society

    CERN Document Server

    Wiberg, Marie; Culpepper, Steven; Douglas, Jeffrey; Wang, Wen-Chung


    This proceedings volume compiles and expands on selected and peer reviewed presentations given at the 81st Annual Meeting of the Psychometric Society (IMPS), organized by the University of North Carolina at Greensboro, and held in Asheville, North Carolina, July 11th to 17th, 2016. IMPS is one of the largest international meetings focusing on quantitative measurement in psychology, education, and the social sciences, both in terms of participants and number of presentations. The meeting built on the Psychometric Society's mission to share quantitative methods relevant to psychology, addressing a diverse set of psychometric topics including item response theory, factor analysis, structural equation modeling, time series analysis, mediation analysis, cognitive diagnostic models, and multi-level models. Selected presenters were invited to revise and expand their contributions and to have them peer reviewed and published in this proceedings volume. Previous volumes to showcase work from the Psychometric Society�...

  13. Best practices for learning physiology: combining classroom and online methods. (United States)

    Anderson, Lisa C; Krichbaum, Kathleen E


    Physiology is a requisite course for many professional allied health programs and is a foundational science for learning pathophysiology, health assessment, and pharmacology. Given the demand for online learning in the health sciences, it is important to evaluate the efficacy of online and in-class teaching methods, especially as they are combined to form hybrid courses. The purpose of this study was to compare two hybrid physiology sections in which one section was offered mostly in-class (85% in-class), and the other section was offered mostly online (85% online). The two sections in 2 yr ( year 1 and year 2 ) were compared in terms of knowledge of physiology measured in exam scores and pretest-posttest improvement, and in measures of student satisfaction with teaching. In year 1 , there were some differences on individual exam scores between the two sections, but no significant differences in mean exam scores or in pretest-posttest improvements. However, in terms of student satisfaction, the mostly in-class students in year 1 rated the instructor significantly higher than did the mostly online students. Comparisons between in-class and online students in the year 2 cohort yielded data that showed that mean exam scores were not statistically different, but pre-post changes were significantly greater in the mostly online section; student satisfaction among mostly online students also improved significantly. Education researchers must investigate effective combinations of in-class and online methods for student learning outcomes, while maintaining the flexibility and convenience that online methods provide. Copyright © 2017 the American Physiological Society.

  14. Solvent hold tank sample results for MCU-16-1488-1493 (December 2016), MCU-17-86-88 (January 2017), and MCU-17-119-121 (February 2017): Quarterly Report

    Energy Technology Data Exchange (ETDEWEB)

    Fondeur, F. F. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Jones, D. H. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)


    A trend summary of three Solvent Hold Tank (SHT) monthly samples; MCU-16-1488-1493 (December 2016), MCU-17-86-88 (January 2017), and MCU-17-119-121 (February 2017) are reported. Analyses indicate that the modifier (CS-7SB) and the extractant (MaxCalix) concentrations are at their nominal recommended levels (169,000 mg/L and 46,300 mg/L respectively). The suppressor (TiDG) level has decreased to a steady state level of 673 mg/L well above the minimum recommended level (479 mg/L). This analysis confirms the Isopar™ addition to the solvent in January 18, 2017. This analysis also indicates the solvent did not require further additions. Based on the current monthly sample, the levels of TiDG, Isopar™L, MaxCalix, and modifier are sufficient for continuing operation but are expected to decrease with time. Periodic characterization and trimming additions to the solvent are recommended. No impurities above the 1000 ppm level were found in this solvent by the Semi-Volatile Organic Analysis (SVOA). No impurities were observed in the Hydrogen Nuclear Magnetic Resonance (HNMR). Another impurity observed in the samples was mercury. Up to 38 ± 8 micrograms of mercury per mL of solvent was detected in these samples (the average of the CV-AA and XRF methods). The higher mercury concentration in the solvent (as determined in the last three monthly samples) is possibly due to the higher mercury concentration in Salt Batches 8 and 9 (Tank 49H) or mixing of previously undisturbed areas of high mercury concentration in Tank 49H. The gamma level (0.21E5 dpm/mL) measured in the February SHT sample was one order of magnitude lower than the gamma levels observed in the December and January SHT samples. The February gamma level is consistent with the solvent being idle (since January 10, 2017). The gamma levels observed in the December and January SHT samples were consistent with previous monthly measurements where the process operated normally. The laboratory will continue to monitor

  15. Diversity in the American Society of Anesthesiologists Leadership. (United States)

    Toledo, Paloma; Duce, Lorent; Adams, Jerome; Ross, Vernon H; Thompson, Kelli M; Wong, Cynthia A


    Women and minorities are underrepresented in US academic medicine. The Sullivan Commission on Diversity in the Healthcare Workforce emphasized the importance of diverse leadership for reducing health care disparities. The objective of this study was to evaluate the demographics of the American Society of Anesthesiologists leadership. We hypothesized that the percentage of women and underrepresented minorities is less than that of their respective proportions in the general physician workforce. An electronic survey was developed by the authors and mailed to 595 members of the American Society of Anesthesiologists leadership who had valid email addresses, including the members of the 2014 House of Delegates and state society leaders who were not the members of the House of Delegates. Univariate statistics were used to characterize survey responses and the probability distributions were estimated using the binomial distribution. A one-sample t test was used to compare the percentage of women and minorities in the survey pool to that of the corresponding percentages in the general physician workforce (38.0% women and 8.9% minorities), and the US population (51.0% women and 32.0% minorities). The survey response rate was 54%. A total of 21.1% (95% confidence interval: 16.4%-25.7%) of respondents were women and 6.0% (95% confidence interval: 3.3%-8.7%) were minorities. The proportion of women in the American Society of Anesthesiologist leadership was lower than the general medical workforce and the US population (P leadership of the American Society of Anesthesiologists. Efforts should be made to increase the diversity of the American Society of Anesthesiologists leadership with the goal of reducing overall anesthesia workforce disparities.

  16. Physiological coherence in healthy volunteers during laboratory-induced stress and controlled breathing. (United States)

    Mejía-Mejía, Elisa; Torres, Robinson; Restrepo, Diana


    Physiological coherence has been related with a general sense of well-being and improvements in health and physical, social, and cognitive performance. The aim of this study was to evaluate the relationship between acute stress, controlled breathing, and physiological coherence, and the degree of body systems synchronization during a coherence-generation exercise. Thirty-four university employees were evaluated during a 20-min test consisting of four stages of 5-min duration each, during which basal measurements were obtained (Stage 1), acute stress was induced using validated mental stressors (Stroop test and mental arithmetic task, during Stage 2 and 3, respectively), and coherence states were generated using a controlled breathing technique (Stage 4). Physiological coherence and cardiorespiratory synchronization were assessed during each stage from heart rate variability, pulse transit time, and respiration. Coherence measurements derived from the three analyzed variables increased during controlled respiration. Moreover, signals synchronized during the controlled breathing stage, implying a cardiorespiratory synchronization was achieved by most participants. Hence, physiological coherence and cardiopulmonary synchronization, which could lead to improvements in health and better life quality, can be achieved using slow, controlled breathing exercises. Meanwhile, coherence measured during basal state and stressful situations did not show relevant differences using heart rate variability and pulse transit time. More studies are needed to evaluate the ability of coherence ratio to reflect acute stress. © 2017 Society for Psychophysiological Research.

  17. Overview of the Anatomy, Physiology, and Pharmacology of the Autonomic Nervous System. (United States)

    Wehrwein, Erica A; Orer, Hakan S; Barman, Susan M


    Comprised of the sympathetic nervous system, parasympathetic nervous system, and enteric nervous system, the autonomic nervous system (ANS) provides the neural control of all parts of the body except for skeletal muscles. The ANS has the major responsibility to ensure that the physiological integrity of cells, tissues, and organs throughout the entire body is maintained (homeostasis) in the face of perturbations exerted by both the external and internal environments. Many commonly prescribed drugs, over-the-counter drugs, toxins, and toxicants function by altering transmission within the ANS. Autonomic dysfunction is a signature of many neurological diseases or disorders. Despite the physiological relevance of the ANS, most neuroscience textbooks offer very limited coverage of this portion of the nervous system. This review article provides both historical and current information about the anatomy, physiology, and pharmacology of the sympathetic and parasympathetic divisions of the ANS. The ultimate aim is for this article to be a valuable resource for those interested in learning the basics of these two components of the ANS and to appreciate its importance in both health and disease. Other resources should be consulted for a thorough understanding of the third division of the ANS, the enteric nervous system. © 2016 American Physiological Society. Compr Physiol 6:1239-1278, 2016. Copyright © 2016 John Wiley & Sons, Inc.

  18. Effects of competitive pressure on expert performance: underlying psychological, physiological, and kinematic mechanisms. (United States)

    Cooke, Andrew; Kavussanu, Maria; McIntyre, David; Boardley, Ian D; Ring, Christopher


    Although it is well established that performance is influenced by competitive pressure, our understanding of the mechanisms which underlie the pressure-performance relationship is limited. The current experiment examined mediators of the relationship between competitive pressure and motor skill performance of experts. Psychological, physiological, and kinematic responses to three levels of competitive pressure were measured in 50 expert golfers, during a golf putting task. Elevated competitive pressure increased putting accuracy, anxiety, effort, and heart rate, but decreased grip force. Quadratic effects of pressure were noted for self-reported conscious processing and impact velocity. Mediation analyses revealed that effort and heart rate partially mediated improved performance. The findings indicate that competitive pressure elicits effects on expert performance through both psychological and physiological pathways. Copyright © 2011 Society for Psychophysiological Research.

  19. Comparison of British Thoracic Society and American Thoracic Society reintroduction guidelines for anti-tuberculous therapy induced liver injury

    International Nuclear Information System (INIS)

    Zuberi, B. F.; Alvi, H.; Zuberi, F. F.; Salahuddin, J.


    Objective: To compare the efficacy of British Thoracic Society and American Thoracic Society guidelines for re-introduction of anti-tuberculous therapy after drug-induced liver injury, and to assess the ease of administration of each guideline on a scale of 1-10. Methods: The randomised prospective interventional study was conducted at the Department of Medicine and Pulmonology, Dow University of Health Sciences, Karachi, from December 2011 to November 2013. Patients with anti-tuberculous therapy drug-induced liver injury were selected. Hepatotoxic anti-tuberculous therapy was stopped and modified anti-tuberculous therapy was started. Patients were followed weekly till clinical and biochemical parameters got stabilised. After stabilisation, the patients were randomised to one of the two groups to receive re-introduction of anti-tuberculous therapy under the guidelines of British Thoracic Society (Group I) or those of American Thoracic Society (Group II). Means of the groups were analysed by Student's t test and proportions were compared by chi-square test. Multivariate analysis was done for age, body mass index and serum albumin for recurrence of drug-induced liver injury after the re-introduction. P value <0.05 was taken as significant. Results: Of the total 325 patients, 163(50.15%) were in Group I, while 162(49.84%) were in Group II. The frequency of recurrence of drug-induced liver injury in Group I was 16 (9.8%) and in Group II it was 18 (11.1%). There was no statistically significant difference between the two groups (p<0.7). Age was positively related with drug-induced liver injury, while body mass index and serum albumin were negatively associated. Conclusion: There was no significant difference between the two major guidelines though the American Thoracic Society guideline was easier to follow. (author)

  20. IL-17 suppresses immune effector functions in human papillomavirus-associated epithelial hyperplasia. (United States)

    Gosmann, Christina; Mattarollo, Stephen R; Bridge, Jennifer A; Frazer, Ian H; Blumenthal, Antje


    Persistent infection with high-risk human papillomaviruses (HPV) causes epithelial hyperplasia that can progress to cancer and is thought to depend on immunosuppressive mechanisms that prevent viral clearance by the host. IL-17 is a cytokine with diverse functions in host defense and in the pathology of autoimmune disorders, chronic inflammatory diseases, and cancer. We analyzed biopsies from patients with HPV-associated cervical intraepithelial neoplasia grade 2/3 and murine skin displaying HPV16 E7 protein-induced epithelial hyperplasia, which closely models hyperplasia in chronic HPV lesions. Expression of IL-17 and IL-23, a major inducer of IL-17, was elevated in both human HPV-infected and murine E7-expressing lesions. Using a skin-grafting model, we demonstrated that IL-17 in HPV16 E7 transgenic skin grafts inhibited effective host immune responses against the graft. IL-17 was produced by CD3(+) T cells, predominantly CD4(+) T cells in human, and CD4(+) and γδ T cells in mouse hyperplastic lesions. IL-23 and IL-1β, but not IL-18, induced IL-17 production in E7 transgenic skin. Together, these findings demonstrate an immunosuppressive role for IL-17 in HPV-associated epithelial hyperplasia and suggest that blocking IL-17 in persistent viral infection may promote antiviral immunity and prevent progression to cancer. Copyright © 2014 by The American Association of Immunologists, Inc.

  1. TMEM16A inhibition impedes capacitation and acquisition of hyperactivated motility in guinea pig sperm. (United States)

    Cordero-Martínez, Joaquín; Reyes-Miguel, Tania; Rodríguez-Páez, Lorena; Garduño-Siciliano, Leticia; Maldonado-García, Deneb; Roa-Espitia, Ana L; Hernández-González, Enrique O


    Ca 2+ -activated Cl - channels (CaCCs) are anionic channels that regulate many important physiological functions associated with chloride and calcium flux in some somatic cells. The molecular identity of CaCCs was revealed to be TMEM16A and TMEM16B (also known as Anoctamin or ANO1 and ANO2, respectively) in all eukaryotes. A recent study suggests the presence of TMEM16A in human sperm and a relationship with the rhZP-induced acrosome reaction. However, to the best of our knowledge, little is known about the role of TMEM16A in other spermatic processes such as capacitation or motility. In this study, we evaluated the effects of two TMEM16A antagonists on capacitation, acrosome reaction, and motility in guinea pig sperm; these antagonists were T16Ainh-A01, belonging to a second generation of potent antagonists of TMEM16A, and niflumic acid (NFA), a well-known antagonist of TMEM16A (CaCCs). First of all, we confirmed that the absence of Cl - in the capacitation medium changes motility parameters, capacitation, and the progesterone-induced acrosome reaction. Using a specific antibody, TMEM16A was found as a protein band of ∼120 kDa, which localization was in the apical crest of the acrosome and the middle piece of the flagellum. Inhibition of TMEM16A by T16Ainh-A01 affected sperm physiology by reducing capacitation, blocking the progesterone-induced acrosome reaction under optimal capacitation conditions, inhibiting progressive motility, and the acquisition of hyperactivated motility, diminishing [Ca 2+ ]i, and increasing [Cl - ]i. These changes in sperm kinematic parameters provide new evidence of the important role played by TMEM16A in the production of sperm capable of fertilizing oocytes. © 2018 Wiley Periodicals, Inc.

  2. Applied physiology of female soccer: an update. (United States)

    Datson, Naomi; Hulton, Andrew; Andersson, Helena; Lewis, Tracy; Weston, Matthew; Drust, Barry; Gregson, Warren


    The popularity and professionalism of female soccer has increased markedly in recent years, with elite players now employed on either a professional or semi-professional basis. The previous review of the physiological demands of female soccer was undertaken two decades ago when the sport was in its relative infancy. Increased research coupled with greater training and competition demands warrants an updated review to consider the effect on physical performance and injury patterns. The physical demands of match-play along with the influence of factors such as the standard of competition, playing position and fatigue have been explored. Total distance covered for elite female players is approximately 10 km, with 1.7 km completed at high speed (>15 kmh(-1)) [corrected].Elite players complete 28% more high-speed running and 24 % more sprinting than moderate-level players. Decrements in high-speed running distance have been reported between and within halves, which may indicate an inability to maintain high-intensity activity. Although the physical capacity of female players is the most thoroughly researched area, comparisons are difficult due to differing protocols. Elite players exhibit maximal oxygen uptake (VO2max) values of 49.4-57.6 mL·kg(-1)·min(-1), Yo Yo Intermittent Endurance test level 2 (YYIE2) scores of 1,774 ± 532 m [mean ± standard deviation (SD)] and 20 m sprint times of 3.17 ± 0.03 s (mean ± SD). Reasons for the increased prevalence of anterior cruciate ligament injuries in females (2-6 times greater than males) are discussed, with anatomical, biomechanical loading and neuromuscular activation differences being cited in the literature. This review presents an in-depth contemporary examination of the applied physiology of the female soccer player.

  3. Doppler radar physiological sensing

    CERN Document Server

    Lubecke, Victor M; Droitcour, Amy D; Park, Byung-Kwon; Singh, Aditya


    Presents a comprehensive description of the theory and practical implementation of Doppler radar-based physiological monitoring. This book includes an overview of current physiological monitoring techniques and explains the fundamental technology used in remote non-contact monitoring methods. Basic radio wave propagation and radar principles are introduced along with the fundamentals of physiological motion and measurement. Specific design and implementation considerations for physiological monitoring radar systems are then discussed in detail. The authors address current research and commercial development of Doppler radar based physiological monitoring for healthcare and other applications.


    Directory of Open Access Journals (Sweden)

    James P. Veale


    Full Text Available Australian Football (AF is Australia's major football code. Despite research in other football codes, to date, no data has been published on the physiological responses of AF players during match play. Fifteen athletes (17.28 ± 0.76 yrs participated in four pre-season matches, sanctioned by Australian Football League (AFL Victoria, investigating Heart Rate (HR, Blood Lactate (BLa, Core Temperature (Tcore, and Hydration status. Match HR was measured continuously using HR monitors. BLa was measured via finger prick lancet at the end of each quarter of play. Tcore was measured by use of ingestible temperature sensor and measured wirelessly at the end of each quarter of play. Hydration status was measured using refractometry, measuring urine specific gravity, and body weight pre and post-match. Environmental conditions were measured continuously during matches. Results of HR responses showed a high exertion of players in the 85-95% maximum HR range. Elevated mean BLa levels, compared to rest, were observed in all players over the duration of the matches (p = 0.007. Mean Tcore rose 0.68 °C between start and end of matches. Mean USG increased between 0.008 g/ml (p = 0.001 with mean body weight decreasing 1.88 kg (p = 0.001. This study illustrates physiological responses in junior AF players playing in the heat as well as providing physiological data for consideration by AF coaching staff when developing specific training programs. Continued research should consider physiological measurements under varying environments, and at all playing levels of AF, to ascertain full physiological responses during AF matches.

  5. Clinical trial experience with prophylactic human papillomavirus 6/11/16/18 vaccine in young black women. (United States)

    Clark, Liana R; Myers, Evan R; Huh, Warner; Joura, Elmar A; Paavonen, Jorma; Perez, Gonzalo; James, Margaret K; Sings, Heather L; Haupt, Richard M; Saah, Alfred J; Garner, Elizabeth I O


    Human papillomavirus (HPV) is the causative agent of cervical cancer. Black women are disproportionally diagnosed and have higher mortality from cervical cancer in the United States. Here we describe the prophylactic efficacy and safety of a quadrivalent HPV-6/11/16/18 vaccine in black women. A total of 700 black women from Latin America, Europe, and North America (aged 16-24 years) received the vaccine or placebo in one of two studies. Analyses focused on the efficacy and safety of the vaccine. Baseline rates of Chlamydia trachomatis infection and history of past pregnancy were more than twice as high in black women compared with the non-black women who were enrolled in these trials. HPV-6/11/16 or 18 DNA was detected in 18% of black women versus 14.6% in non-black women at day 1. For black women, vaccine efficacy against disease caused by HPV-6/11/16/18 was 100% for cervical intraepithelial neoplasia (0 vs. 15 cases; 95% confidence interval, 64.5%-100%) and 100% for vulvar and vaginal intraepithelial neoplasia and condylomata acuminata (0 vs. 17 cases; 95% confidence interval, 69.3%-100%). There were no serious vaccine-related adverse experiences. A similar proportion of pregnancies resulted in live births (75.8% vaccine; 72.7% placebo) and fetal loss (24.2% vaccine; 27.3% placebo). Prophylactic quadrivalent HPV-6/11/16/18 vaccination of young black women demonstrated high efficacy, safety, and tolerability. HPV vaccination has the potential to reduce cervical cancer-related health disparities both in the United States and around the world. Copyright © 2013 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

  6. Processing of the 17-S Escherichia coli precursor RNA in the 27-S pre-ribosomal particle

    Energy Technology Data Exchange (ETDEWEB)

    Hayes, F; Vasseur, M [Institut de Biologie Physico-Chimique, 75 - Paris (France)


    An RNase activity probably involved in the maturation of 16-S pre-ribosomal RNA in Escherichia coli has been partially purified from crude cell extracts. When 27-S ribosome precursor particles are incubated with this enzyme preparation in vitro, their 17-S RNA is converted to a product with the same electrophoretic mobility as mature 16-S rRNA. FingerprS rRNA. Generation of the normal 5'-P terminus seems to require a factor present in cell extracts since incubation of the 27-S precursor particle in an extract obtained after centrifugation at 30,000 x g causes conversion of the 17-S RNA to a 16-S species containing both termini of mature 16-S rRNS. Preliminary experiments suggest that correct maturation of the 5' end of the 17-S precursor RNA requires a system in which protein synthesis can take place.

  7. Psychophysical and physiological responses to gratings with luminance and chromatic components of different spatial frequencies. (United States)

    Cooper, Bonnie; Sun, Hao; Lee, Barry B


    Gratings that contain luminance and chromatic components of different spatial frequencies were used to study the segregation of signals in luminance and chromatic pathways. Psychophysical detection and discrimination thresholds to these compound gratings, with luminance and chromatic components of the one either half or double the spatial frequency of the other, were measured in human observers. Spatial frequency tuning curves for detection of compound gratings followed the envelope of those for luminance and chromatic gratings. Different grating types were discriminable at detection threshold. Fourier analysis of physiological responses of macaque retinal ganglion cells to compound waveforms showed chromatic information to be restricted to the parvocellular pathway and luminance information to the magnocellular pathway. Taken together, the human psychophysical and macaque physiological data support the strict segregation of luminance and chromatic information in independent channels, with the magnocellular and parvocellular pathways, respectively, serving as likely the physiological substrates. © 2012 Optical Society of America

  8. Interleukin-17 Gene Polymorphisms Contribute to Cancer Risk

    Directory of Open Access Journals (Sweden)

    Yu-Ming Niu


    Full Text Available Epidemiological studies have suggested that interleukin-17 (IL-17 polymorphisms are associated with cancer risk. However, the results of these studies are inconsistent. Therefore, we performed a meta-analysis to obtain a precise conclusion. Odds ratios (ORs with 95% confidence intervals (CIs were used to assess the association of the IL-17A rs2275913G>A and IL-17F rs763780T>C polymorphisms with cancer risk. Publication bias and sensitivity analyses were performed to ensure the statistical power. Overall, 10 relevant case-control studies involving 4,516 cases and 5,645 controls were included. The pooled ORs with 95% CIs indicated that the IL-17A rs2275913G>A polymorphism was significantly associated with increased cancer risk (for A versus G: OR = 1.28, 95% CI: 1.16–1.41, PC polymorphism was also significantly associated with gastric cancer development. Overall, the present meta-analysis suggests that IL-17 polymorphisms increase the risk of developing cancer, particularly gastric cancer, in the Asian (and Chinese population.

  9. Paul Ehrlich: the Nobel Prize in physiology or medicine 1908. (United States)

    Piro, Anna; Tagarelli, Antonio; Tagarelli, Giuseppe; Lagonia, Paolo; Quattrone, Aldo


    We wish to commemorate Paul Ehrlich on the centennial of his being awarded the Nobel Prize in Physiology or Medicine in 1908. His studies are now considered as milestones in immunology: the morphology of leukocytes; his side-chain theory where he defined the cellular receptor for first time; and his clarification of the difference between serum therapy and chemotherapy. Ehrlich also invented the first chemotherapeutic drug: compound 606, or Salvarsan. We have used some original documents from the Royal Society of London, where Ehrlich was a fellow, and from Leipzig University, where he took a degree in medicine.

  10. The Society of Thoracic Surgeons, The Society of Cardiovascular Anesthesiologists, and The American Society of ExtraCorporeal Technology: Clinical Practice Guidelines-Anticoagulation During Cardiopulmonary Bypass. (United States)

    Shore-Lesserson, Linda; Baker, Robert A; Ferraris, Victor A; Greilich, Philip E; Fitzgerald, David; Roman, Philip; Hammon, John W


    Despite more than a half century of "safe" cardiopulmonary bypass (CPB), the evidence base surrounding the conduct of anticoagulation therapy for CPB has not been organized into a succinct guideline. For this and other reasons, there is enormous practice variability relating to the use and dosing of heparin, monitoring heparin anticoagulation, reversal of anticoagulation, and the use of alternative anticoagulants. To address this and other gaps, The Society of Thoracic Surgeons, the Society of Cardiovascular Anesthesiologists, and the American Society of Extracorporeal Technology developed an Evidence Based Workgroup. This was a group of interdisciplinary professionals gathered to summarize the evidence and create practice recommendations for various aspects of CPB. To date, anticoagulation practices in CPB have not been standardized in accordance with the evidence base. This clinical practice guideline was written with the intent to fill the evidence gap and to establish best practices in anticoagulation therapy for CPB using the available evidence. To identify relevant evidence, a systematic review was outlined and literature searches were conducted in PubMed using standardized medical subject heading (MeSH) terms from the National Library of Medicine list of search terms. Search dates were inclusive of January 2000 to December 2015. The search yielded 833 abstracts, which were reviewed by two independent reviewers. Once accepted into the full manuscript review stage, two members of the writing group evaluated each of 286 full papers for inclusion eligibility into the guideline document. Ninety-six manuscripts were included in the final review. In addition, 17 manuscripts published before 2000 were included to provide method, context, or additional supporting evidence for the recommendations as these papers were considered sentinel publications. Members of the writing group wrote and developed recommendations based on review of the articles obtained and achieved

  11. The pipeline of physiology courses in community colleges: to university, medical school, and beyond. (United States)

    McFarland, Jenny; Pape-Lindstrom, Pamela


    Community colleges are significant in the landscape of undergraduate STEM (science technology, engineering, and mathematics) education (9), including biology, premedical, and other preprofessional education. Thirty percent of first-year medical school students in 2012 attended a community college. Students attend at different times in high school, their first 2 yr of college, and postbaccalaureate. The community college pathway is particularly important for traditionally underrepresented groups. Premedical students who first attend community college are more likely to practice in underserved communities (2). For many students, community colleges have significant advantages over 4-yr institutions. Pragmatically, they are local, affordable, and flexible, which accommodates students' work and family commitments. Academically, community colleges offer teaching faculty, smaller class sizes, and accessible learning support systems. Community colleges are fertile ground for universities and medical schools to recruit diverse students and support faculty. Community college students and faculty face several challenges (6, 8). There are limited interactions between 2- and 4-yr institutions, and the ease of transfer processes varies. In addition, faculty who study and work to improve the physiology education experience often encounter obstacles. Here, we describe barriers and detail existing resources and opportunities useful in navigating challenges. We invite physiology educators from 2- and 4-yr institutions to engage in sharing resources and facilitating physiology education improvement across institutions. Given the need for STEM majors and health care professionals, 4-yr colleges and universities will continue to benefit from students who take introductory biology, physiology, and anatomy and physiology courses at community colleges. Copyright © 2016 The American Physiological Society.

  12. Physiological Effects of Touching Coated Wood

    Directory of Open Access Journals (Sweden)

    Harumi Ikei


    Full Text Available This study examined the physiological effects of touching wood with various coating with the palm of the hand on brain activity and autonomic nervous activity. Participants were 18 female university students (mean age, 21.7 ± 1.6 years. As an indicator of brain activity, oxyhemoglobin concentrations were measured in the left and right prefrontal cortices using near-infrared time-resolved spectroscopy. Heart rate variability (HRV and heart rate were used as indicators of autonomic nervous activity. The high-frequency (HF component of HRV, which reflects parasympathetic nervous activity, and the low-frequency (LF/HF ratio, which reflects sympathetic nervous activity, were measured. Plates of uncoated, oil-finished, vitreous-finished, urethane-finished, and mirror-finished white oak wood were used as tactile stimuli. After sitting at rest with their eyes closed for 60 s, participants touched the stimuli with their palm for 90 s each. The results indicated that tactile stimulation with uncoated wood calmed prefrontal cortex activity (vs. urethane finish and mirror finish, increased parasympathetic nervous activity (vs. vitreous finish, urethane finish, and mirror finish, and decreased heart rate (vs. mirror finish, demonstrating a physiological relaxation effect. Further, tactile stimulation with oil- and vitreous-finished wood calmed left prefrontal cortex activity and decreased heart rate relative to mirror-finished wood.

  13. Physiological Effects of Touching Coated Wood. (United States)

    Ikei, Harumi; Song, Chorong; Miyazaki, Yoshifumi


    This study examined the physiological effects of touching wood with various coating with the palm of the hand on brain activity and autonomic nervous activity. Participants were 18 female university students (mean age, 21.7 ± 1.6 years). As an indicator of brain activity, oxyhemoglobin concentrations were measured in the left and right prefrontal cortices using near-infrared time-resolved spectroscopy. Heart rate variability (HRV) and heart rate were used as indicators of autonomic nervous activity. The high-frequency (HF) component of HRV, which reflects parasympathetic nervous activity, and the low-frequency (LF)/HF ratio, which reflects sympathetic nervous activity, were measured. Plates of uncoated, oil-finished, vitreous-finished, urethane-finished, and mirror-finished white oak wood were used as tactile stimuli. After sitting at rest with their eyes closed for 60 s, participants touched the stimuli with their palm for 90 s each. The results indicated that tactile stimulation with uncoated wood calmed prefrontal cortex activity (vs. urethane finish and mirror finish), increased parasympathetic nervous activity (vs. vitreous finish, urethane finish, and mirror finish), and decreased heart rate (vs. mirror finish), demonstrating a physiological relaxation effect. Further, tactile stimulation with oil- and vitreous-finished wood calmed left prefrontal cortex activity and decreased heart rate relative to mirror-finished wood.

  14. The effects of acute alcohol exposure on the response properties of neurons in visual cortex area 17 of cats

    International Nuclear Information System (INIS)

    Chen Bo; Xia Jing; Li Guangxing; Zhou Yifeng


    Physiological and behavioral studies have demonstrated that a number of visual functions such as visual acuity, contrast sensitivity, and motion perception can be impaired by acute alcohol exposure. The orientation- and direction-selective responses of cells in primary visual cortex are thought to participate in the perception of form and motion. To investigate how orientation selectivity and direction selectivity of neurons are influenced by acute alcohol exposure in vivo, we used the extracellular single-unit recording technique to examine the response properties of neurons in primary visual cortex (A17) of adult cats. We found that alcohol reduces spontaneous activity, visual evoked unit responses, the signal-to-noise ratio, and orientation selectivity of A17 cells. In addition, small but detectable changes in both the preferred orientation/direction and the bandwidth of the orientation tuning curve of strongly orientation-biased A17 cells were observed after acute alcohol administration. Our findings may provide physiological evidence for some alcohol-related deficits in visual function observed in behavioral studies.

  15. 47 CFR 17.17 - Existing structures. (United States)


    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Existing structures. 17.17 Section 17.17... STRUCTURES Federal Aviation Administration Notification Criteria § 17.17 Existing structures. (a) The requirements found in § 17.23 relating to painting and lighting of antenna structures shall not apply to those...

  16. Temperature during the last week of incubation. III. Effects on chicken embryo physiology

    NARCIS (Netherlands)

    Maatjens, C.M.; Roovert-Reijrink, van I.A.M.; Engel, B.; Pol, van der C.W.; Kemp, B.; Brand, van den H.


    We investigated effects of eggshell temperature (EST) of 35.6, 36.7, 37.8, or 38.9°C applied from d of incubation (E) 15, E17, or E19 onward on chicken embryo physiology. A total of 2,850 first-grade eggs of a 43-week-old Ross 308 broiler breeder flock were incubated at an EST of 37.8°C until E15.

  17. Similarity of WISC-R and WAIS-R Scores at Age 16. (United States)

    Sandoval, Jonathan; And Others


    Examined similarity of scores of 30 learning disabled students (aged 16 and 17) on the Wechsler Intelligence Scale for Children-Revised (WISC-R) and the Wechsler Adult Intelligence Scale-Revised (WAIS-R). Results documented similarity between WISC-R and WAIS-R for 16 year-olds who were learning disabled and had average intellectual ability.…

  18. The structure of physical fitness and its correlation analysis at young players aged 16-17 years at the stage of basic training

    Directory of Open Access Journals (Sweden)

    A.N. POPOV


    Full Text Available Purpose : The questions about the importance of physical fitness of young players to improve the management and correction of the training process. Material : In the research participated 40 players aged 16-17 years of specialized youth football school of FC "Obolon-Brewery". Data for the study of physical fitness were teacher observations and teacher testing carried out under the direct training of young players. Results : It is shown that the structure of physical fitness among all the studied parameters there is a close correlation relationship, except for a parameter that characterizes the start speed. It was found that the above regularities indicate the advisability of excluding the studied parameters in the structure of physical fitness of young players to improve the efficiency of the training process at the base of specialized training. Conclusions : It is recommended to improve the starting speed to use non-gaming and technical and tactical exercises.

  19. Physiological adaptations to interval training and the role of exercise intensity. (United States)

    MacInnis, Martin J; Gibala, Martin J


    Interval exercise typically involves repeated bouts of relatively intense exercise interspersed by short periods of recovery. A common classification scheme subdivides this method into high-intensity interval training (HIIT; 'near maximal' efforts) and sprint interval training (SIT; 'supramaximal' efforts). Both forms of interval training induce the classic physiological adaptations characteristic of moderate-intensity continuous training (MICT) such as increased aerobic capacity (V̇O2 max ) and mitochondrial content. This brief review considers the role of exercise intensity in mediating physiological adaptations to training, with a focus on the capacity for aerobic energy metabolism. With respect to skeletal muscle adaptations, cellular stress and the resultant metabolic signals for mitochondrial biogenesis depend largely on exercise intensity, with limited work suggesting that increases in mitochondrial content are superior after HIIT compared to MICT, at least when matched-work comparisons are made within the same individual. It is well established that SIT increases mitochondrial content to a similar extent to MICT despite a reduced exercise volume. At the whole-body level, V̇O2 max is generally increased more by HIIT than MICT for a given training volume, whereas SIT and MICT similarly improve V̇O2 max despite differences in training volume. There is less evidence available regarding the role of exercise intensity in mediating changes in skeletal muscle capillary density, maximum stroke volume and cardiac output, and blood volume. Furthermore, the interactions between intensity and duration and frequency have not been thoroughly explored. While interval training is clearly a potent stimulus for physiological remodelling in humans, the integrative response to this type of exercise warrants further attention, especially in comparison to traditional endurance training. © 2016 The Authors. The Journal of Physiology © 2016 The Physiological Society.

  20. Are your students ready for anatomy and physiology? Developing tools to identify students at risk for failure. (United States)

    Gultice, Amy; Witham, Ann; Kallmeyer, Robert


    High failure rates in introductory college science courses, including anatomy and physiology, are common at institutions across the country, and determining the specific factors that contribute to this problem is challenging. To identify students at risk for failure in introductory physiology courses at our open-enrollment institution, an online pilot survey was administered to 200 biology students. The survey results revealed several predictive factors related to academic preparation and prompted a comprehensive analysis of college records of >2,000 biology students over a 5-yr period. Using these historical data, a model that was 91% successful in predicting student success in these courses was developed. The results of the present study support the use of surveys and similar models to identify at-risk students and to provide guidance in the development of evidence-based advising programs and pedagogies. This comprehensive approach may be a tangible step in improving student success for students from a wide variety of backgrounds in anatomy and physiology courses. Copyright © 2015 The American Physiological Society.

  1. Personalized physiological medicine. (United States)

    Ince, Can


    This paper introduces the concept of personalized physiological medicine that is specifically directed at the needs of the critically ill patient. This differs from the conventional view of personalized medicine, characterized by biomarkers and gene profiling, instead focusing on time-variant changes in the pathophysiology and regulation of various organ systems and their cellular and subcellular constituents. I propose that personalized physiological medicine is composed of four pillars relevant to the critically ill patient. Pillar 1 is defined by the frailty and fitness of the patient and their physiological reserve to cope with the stress of critical illness and therapy. Pillar 2 involves monitoring of the key physiological variables of the different organ systems and their response to disease and therapy. Pillar 3 concerns the evaluation of the success of resuscitation by assessment of the hemodynamic coherence between the systemic and microcirculation and parenchyma of the organ systems. Finally, pillar 4 is defined by the integration of the physiological and clinical data into a time-learning adaptive model of the patient to provide feedback about the function of organ systems and to guide and assess the response to disease and therapy. I discuss each pillar and describe the challenges to research and development that will allow the realization of personalized physiological medicine to be practiced at the bedside for critically ill patients.

  2. Multilevel functional genomics data integration as a tool for understanding physiology: a network biology perspective. (United States)

    Davidsen, Peter K; Turan, Nil; Egginton, Stuart; Falciani, Francesco


    The overall aim of physiological research is to understand how living systems function in an integrative manner. Consequently, the discipline of physiology has since its infancy attempted to link multiple levels of biological organization. Increasingly this has involved mathematical and computational approaches, typically to model a small number of components spanning several levels of biological organization. With the advent of "omics" technologies, which can characterize the molecular state of a cell or tissue (intended as the level of expression and/or activity of its molecular components), the number of molecular components we can quantify has increased exponentially. Paradoxically, the unprecedented amount of experimental data has made it more difficult to derive conceptual models underlying essential mechanisms regulating mammalian physiology. We present an overview of state-of-the-art methods currently used to identifying biological networks underlying genomewide responses. These are based on a data-driven approach that relies on advanced computational methods designed to "learn" biology from observational data. In this review, we illustrate an application of these computational methodologies using a case study integrating an in vivo model representing the transcriptional state of hypoxic skeletal muscle with a clinical study representing muscle wasting in chronic obstructive pulmonary disease patients. The broader application of these approaches to modeling multiple levels of biological data in the context of modern physiology is discussed. Copyright © 2016 the American Physiological Society.

  3. Transactions of the 1982 Eastern Regional American Nuclear Society student conference

    International Nuclear Information System (INIS)


    The 1982 Eastern Region ANS Student Conference of the ANS Student Branch and the School of Nuclear Engineering and Health Physics was held at Georgia Tech., April 16-17, 1982. Almost all the papers have been entered individually into EDB and ERA

  4. Abundance and Charge State of Implanted Solar Wind Transition Metals in Individual Apollo 16 and 17 Lunar Soil Plagioclase Grains Determined In Situ Using Synchrotron X-ray Fluorescence

    International Nuclear Information System (INIS)

    Kitts, K.; Sutton, S.; Newville, M.


    We report (1) a new method for determining the relative abundances in situ of Cr, Mn, Fe and Ni in implanted solar wind in individual Apollo 16 and 17 lunar plagioclases via synchrotron X-ray fluorescence and (2) the charge states of these metals. By virture of its mass alone, the Sun provides a representative composition of the solar system and can be used as a background against which to gauge excesses or deficiencies of specific components. One way of sampling the Sun is by measuring solar wind implanted ions in lunar soil grains. Such measurements are valuable because of their long exposure ages which compliment shorter time scale collections, such as those obtained by the Genesis spacecraft. Kitts et al. sought to determine the isotopic composition of solar Cr by analyzing the solar wind implanted into plagioclase grains from Apollo 16 lunar soils. The isotopic composition of the solar wind bearing fraction was anomalous and did not match any other known Cr isotopic signature. This could only be explained by either (1) an enrichment in the solar wind of heavy Cr due to spallation in the solar atmosphere or (2) that the Earth and the various parent bodies of the meteorites are distinct from the Sun and must have formed from slightly different mixes of presolar materials. To help resolve this issue, we have developed a wholly independent method for determining the relative abundances of transition metals in the solar wind implanted in individual lunar soil grains. This method is based on in situ abundance measurements by microbeam x-ray fluorescence in both the implantation zone and bulk grains using the synchrotron x-ray microprobe at the Advanced Photon Source (GSECARS sector 13) at Argonne National Laboratory. Here, we report results for Apollo 16 and 17 plagioclase grains. Additionally, a micro-XANES technique was used to determine charge states of the implanted Cr, Mn, Fe and Ni.

  5. Plant Physiology in Greenhouses

    NARCIS (Netherlands)

    Heuvelink, E.; Kierkels, T.


    Since 2004 Ep Heuvelink and Tijs Kierkels have been writing a continuing series of plant physiology articles for the Dutch horticultural journal Onder Glas and the international edition In Greenhouses. The book Plant Physiology in Greenhouses consists of 50 of their plant physiology articles. The

  6. Superplastic forming of the Cd-17.4Zn alloy; Conformado superplastico de la aleacion Cd-17.4Zn

    Energy Technology Data Exchange (ETDEWEB)

    Llanes-Briceno, J. A.; Torres-Villasenor, G. [Universidad Nacional Autonoma de Mexico, Mexico, D.F. (Mexico)


    In the present work the necessary steps to carry on the superplastic forming of the Cd-17.4Zn alloy are defined. The use of either atmospheric pressure or gas pressure as forming tools is analyzed. The optimum values of the variable involved (temperature, maximum strain and sensitivity index) are determined while a method for the characterization of futures superplastic alloys is set forth. The experimental characterization of the superplastic forming is achieved with free bulging of circular membranes of 12, 16, 24, 32 and 40 mm in diameter and with three different membrane thicknesses (0.4, 0.6, 0.8 mm). [Spanish] Se definen los pasos necesarios para el conformado superplastico de la aleacion Cd-17.4 Zn. Se comparan la presion atmosferica y el gas a presion como herramientas de conformado. Se determinan los valores optimos de la variables involucradas (temperatura, deformacion maxima e indice de sensibilidad) y se plantea una metodologia para la caracterizacion de futuras aleaciones superplasticas. El conformado superplastico se caracteriza experimentalmente mediante el inflado libre de membranas circulares de 12, 16, 24, 32 y 40 mm de diametro y tres diferentes espesores (0.4, 0.6 y 0.8 mm). Se muestra la estructura perlitica (enfuiada al aive Cd-17.4Zn) y la estructura grano fino. Se muestra la profundidad de deformacion en tres espesores (0.4, 0.6, 0.8 mm) a P=200 Kpa y T = 200 y a T = 230.

  7. Planetary Society (United States)

    Murdin, P.


    Carl Sagan, Bruce Murray and Louis Friedman founded the non-profit Planetary Society in 1979 to advance the exploration of the solar system and to continue the search for extraterrestrial life. The Society has its headquarters in Pasadena, California, but is international in scope, with 100 000 members worldwide, making it the largest space interest group in the world. The Society funds a var...

  8. Does John 17:11b, 21−23 refer to church unity?

    Directory of Open Access Journals (Sweden)

    Gert J. Malan


    Full Text Available In ecumenical circles, John 17:11b, 21–23 has been understood as Jesus’ prayer for church unity, be it confessional or structural. This article questioned such readings and conclusions from historical, literary and sosio-cultural viewpoints. The Fourth Gospel’s language is identified as ’antilanguage’ typical of an ’antisociety’, like that of the Hermetic, Mandean and Qumran sects. Such a society is a separate entity within society at large, but opposes it. Read as a text of an antisociety, John 17:11b, 21–23 legitimises the unity of the separatist Johannine community, which could have comprised several such communities. This community opposed the Judean religion, Gnosticism, the followers of John the Baptist and three major groups in early Christianity. As text from the canon, this Johannine text legitimates tolerance of diversity rather than the confessional or structural unity of the church.

  9. Indirect Effects of Global Change: From Physiological and Behavioral Mechanisms to Ecological Consequences. (United States)

    Gunderson, Alex R; Tsukimura, Brian; Stillman, Jonathon H


    A major focus of current ecological research is to understand how global change makes species vulnerable to extirpation. To date, mechanistic ecophysiological analyses of global change vulnerability have focused primarily on the direct effects of changing abiotic conditions on whole-organism physiological traits, such as metabolic rate, locomotor performance, cardiac function, and critical thermal limits. However, species do not live in isolation within their physical environments, and direct effects of climate change are likely to be compounded by indirect effects that result from altered interactions with other species, such as competitors and predators. The Society for Integrative and Comparative Biology 2017 Symposium "Indirect Effects of Global Change: From Physiological and Behavioral Mechanisms to Ecological Consequences" was designed to synthesize multiple approaches to investigating the indirect effects of global change by bringing together researchers that study the indirect effects of global change from multiple perspectives across habitat, type of anthropogenic change, and level of biological organization. Our goal in bringing together researchers from different backgrounds was to foster cross-disciplinary insights into the mechanistic bases and higher-order ecological consequences of indirect effects of global change, and to promote collaboration among fields. © The Author 2017. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email:

  10. Society News: Queen honours Fellows; The Society and legacies; Thesis prizes; Lectures on laptops; Stonehenge story (United States)


    The Queen's Birthday Honours list announced on 16 June contained some familiar names from astronomy. Prof. Mark Bailey (1) of Armagh Observatory, currently a Vice-President of the RAS, was awarded an MBE and Dr Heather Couper (2), former President of the British Astronomical Association, a CBE. Prof. Nigel Mason (3) of the Open University and inaugural Director of the Milton Keynes Science Festival received an OBE. Prof. Jocelyn Bell-Burnell (4), President of the RAS from 2002-2004, was awarded a DBE - and an Honorary Doctorate from Harvard University. In addition, Prof. Lord Rees (5), Astronomer Royal, president of the Royal Society and President of the RAS from 1992-1994, was appointed to the Order of Merit.

  11. Detecting 16S rRNA Methyltransferases in Enterobacteriaceae by Use of Arbekacin. (United States)

    McGann, Patrick; Chahine, Sarah; Okafor, Darius; Ong, Ana C; Maybank, Rosslyn; Kwak, Yoon I; Wilson, Kerry; Zapor, Michael; Lesho, Emil; Hinkle, Mary


    16S rRNA methyltransferases confer resistance to most aminoglycosides, but discriminating their activity from that of aminoglycoside-modifying enzymes (AMEs) is challenging using phenotypic methods. We demonstrate that arbekacin, an aminoglycoside refractory to most AMEs, can rapidly detect 16S methyltransferase activity in Enterobacteriaceae with high specificity using the standard disk susceptibility test. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  12. NCBI nr-aa BLAST: CBRC-MMUS-17-0191 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-17-0191 ref|NP_334701.1| hypothetical protein MT0291.4 [Mycobacterium tuberculosis... CDC1551] gb|AAK44515.1| hypothetical protein MT0291.4 [Mycobacterium tuberculosis CDC1551] NP_334701.1 2e-16 33% ...

  13. Success of an International Learning Health Care System in Hematopoietic Cell Transplantation: The American Society of Blood and Marrow Transplantation Clinical Case Forum. (United States)

    Barba, Pere; Burns, Linda J; Litzow, Mark R; Juckett, Mark B; Komanduri, Krishna V; Lee, Stephanie J; Devlin, Sean M; Costa, Luciano J; Khan, Shakila; King, Andrea; Klein, Andreas; Krishnan, Amrita; Malone, Adriana; Mir, Muhammad; Moravec, Carina; Selby, George; Roy, Vivek; Cochran, Melissa; Stricherz, Melisa K; Westmoreland, Michael D; Perales, Miguel-Angel; Wood, William A


    The American Society for Blood and Marrow Transplantation (ASBMT) Clinical Case Forum (CCF) was launched in 2014 as an online secure tool to enhance interaction and communication among hematopoietic cell transplantation (HCT) professionals worldwide through the discussion of challenging clinical care issues. After 14 months, we reviewed clinical and demographical data of cases posted in the CCF from January 29, 2014 to March 18, 2015. A total of 137 cases were posted during the study period. Ninety-two cases (67%) were allogeneic HCT, 29 (21%) were autologous HCT, and in 16 (12%), the type of transplantation (autologous versus allogeneic) was still under consideration. The diseases most frequently discussed included non-Hodgkin lymphoma (NHL; n = 30, 22%), acute myeloid leukemia (n = 23, 17%), and multiple myeloma (MM; n = 20, 15%). When compared with the US transplantation activity reported by the US Department of Health and Human Services, NHL and acute lymphoblastic leukemia cases were over-represented in the CCF, whereas MM was under-represented (P educational and research perspectives. Copyright © 2016 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.



    Apollo 16 commander John W. Young prepares to enter the lunar module in an altitude chamber in the Manned Spacecraft Operations Building at the spaceport prior to an altitude run. During the altitude run, in which Apollo 16 lunar module pilot Charles M. Duke also participated, the chamber was pumped down to simulate pressure at an altitude in excess of 200,000 feet. Young, Duke and command module pilot Thomas K. Mattingly II, are training at the Kennedy Space Center for the Apollo 16 mission. Launch is scheduled from Pad 39A, March 17, 1972.

  15. Relasi Islam dan Politik dalam Sejarah Politik Aceh Abad 16-17

    Directory of Open Access Journals (Sweden)

    Kamaruzzaman Kamaruzzaman


    الملخص : يهدف هذا البحث المتواضع إلى القيام ببيان تطور العلاقة بين الإسلام والسياسة في القرنين 17-16 من الميلاد في أتشيه. وكانت أتشيه أنذاك – تاريخيّا - قد بلغت شهرتها في مجالات شتى لا سيما بتقدمها العلمي بالإضافة إلى المجال السياسي. هنا سيحلّل الباحث خلال تناوله لهذه الدراسة الأجواء التى تقوم وراء الارتباط  الوثيق بين الإسلام والسياسة في ذلك العهد المتميز. نعم, ثمّة كثير من التغيّرات والتحوّلات للأوضاع السياسية في تاريخ أتشيه حسب ما اطّلع عليه الباحث من كتب التاريخ. انطلاقا من النظرية المعرفية الإجتماعية والتاريخية, يسعى بها الباحث إلي معرفة تلك المراحل العريقة التي شهدها التاريخ ويسير شعب أتشيه على نهجها. والحديث عنها يستند إلى أدلة حاسمة تاريخية تبرهن عند التحقق بمدى تعامل الإسلام بالسياسة. وهذه البراهن كانت واضحة وضوح الشمس في رابعة النهار من خلال اكتشاف الباحث على تاريخ مملكة أتشيه دار السلام، وفي هذا الإطار وجد عند تأمله الدقيق لبعض الكتب المؤلفة من قبل علمائها في هذين القرنين العظيمين تعبر أثناء تعرضهم حول الفكر السياسي وتكاملها وتطابقها بالدين. هذه الدراسة تظهر قوة التفاعل بين الإسلام والسياسة في جنوب شرق آسيا من غير تفرّق ولا تمزّق، حيث لا يعرف شعبها وحكّامها الفصل بين

  16. Effects of internal and external environment on health and well-being: from cell to society. (United States)

    Tomljenović, Andrea


    Stem cell fate in cell culture depends on the composition of the culturing media. Every single cell in an organism is influenced by its microenvironment and surrounding cells. Biology, psychology, emotions, spirit, energy, lifestyle, culture, economic and political influences, social interactions in family, work, living area and the possibilities to expresses oneself and live full life with a sense of well-being have influence on people appearances. Disease is as much social as biological. It is a reaction of an organism to unbalancing changes in the internal environment caused by the changes in the external environment and/or by the structural and functional failures or unfortunate legacies. Health gradient in the society depends on the every day circumstances in which people live and work. The health of the population is an insight into the society. The problem facing medicine in the complex society of today cannot be resolved without the aid of social sciences, as cultural, social, ecological and mental processes affect physiological responses and health outcomes. Anthropology could be a bridge between biomedicine and social sciences and influence strategies in public health to prevent rather than cure and in education for fulfillment in life and improvement of society.

  17. Calibrated high-precision 17O-excess measurements using cavity ring-down spectroscopy with laser-current-tuned cavity resonance

    Directory of Open Access Journals (Sweden)

    E. J. Steig


    Full Text Available High-precision analysis of the 17O / 16O isotope ratio in water and water vapor is of interest in hydrological, paleoclimate, and atmospheric science applications. Of specific interest is the parameter 17O excess (Δ17O, a measure of the deviation from a~linear relationship between 17O / 16O and 18O / 16O ratios. Conventional analyses of Δ17O of water are obtained by fluorination of H2O to O2 that is analyzed by dual-inlet isotope ratio mass spectrometry (IRMS. We describe a new laser spectroscopy instrument for high-precision Δ17O measurements. The new instrument uses cavity ring-down spectroscopy (CRDS with laser-current-tuned cavity resonance to achieve reduced measurement drift compared with previous-generation instruments. Liquid water and water-vapor samples can be analyzed with a better than 8 per meg precision for Δ17O using integration times of less than 30 min. Calibration with respect to accepted water standards demonstrates that both the precision and the accuracy of Δ17O are competitive with conventional IRMS methods. The new instrument also achieves simultaneous analysis of δ18O, Δ17O and δD with precision of < 0.03‰, < 0.02 and < 0.2‰, respectively, based on repeated calibrated measurements.

  18. Selection of physiological parameters for optoelectronic system supporting behavioral therapy of autistic children (United States)

    Landowska, A.; Karpienko, K.; Wróbel, M.; Jedrzejewska-Szczerska, M.


    In this article the procedure of selection of physiological parameters for optoelectronic system supporting behavioral therapy of autistic children is proposed. Authors designed and conducted an experiment in which a group of 30 health volunteers (16 females and 14 males) were examined. Under controlled conditions people were exposed to a stressful situation caused by the picture or sound (1kHz constant sound, which was gradually silenced and finished with a shot sound). For each of volunteers, a set of physiological parameters were recorded, including: skin conductance, heart rate, peripheral temperature, respiration rate and electromyography. The selected characteristics were measured in different locations in order to choose the most suitable one for the designed therapy supporting system. The bio-statistical analysis allowed us to discern the proper physiological parameters that are most associated to changes due to emotional state of a patient, such as: skin conductance, temperatures and respiration rate. This allowed us to design optoelectronic sensors network for supporting behavioral therapy of children with autism.

  19. Physiological Laterality of Superficial Cerebral Veins on Susceptibility-Weighted Imaging. (United States)

    Matsushima, Satoshi; Shimizu, Tetsuya; Gomi, Taku; Fukuda, Kunihiko

    The purpose of this study is to evaluate whether laterality of the superficial cerebral veins can be seen on susceptibility-weighted imaging (SWI) in patients with no intracranial lesions that affect venous visualization. We retrospectively evaluated 386 patients who underwent brain magnetic resonance imaging including SWI in our institute. Patients with a lesion with the potential to affect venous visualization on SWI were excluded. Two neuroradiologists visually evaluated the findings and scored the visualization of the superficial cerebral veins. Of the 386 patients, 315 (81.6%) showed no obvious laterality on venous visualization, 64 (16.6%) showed left-side dominant laterality, and 7 (1.8%) showed right-side dominant laterality. Left-side dominant physiological laterality exists in the visualization of the superficial cerebral veins on SWI. Therefore, when recognizing left-side dominant laterality of the superficial cerebral veins on SWI, the radiologist must also consider the possibility of physiological laterality.

  20. Physiological correlates of peer victimization and aggression in African American urban adolescents (United States)



    This study examined physiological correlates (cortisol and α-amylase [AA]) of peer victimization and aggression in a sample of 228 adolescents (45% male, 55% female; 90% African American; M age = 14 years, SD = 1.6 years) who participated in a longitudinal study of stress, physiology, and adjustment. Adolescents were classified into victimization/aggression groups based on patterns with three waves of data. At Wave 3, youth completed the Social Competence Interview (SCI), and four saliva samples were collected prior to, during, and following the SCI. Repeated-measures analyses of variance with victimization/aggression group as the predictor, and physiological measures as outcomes, controlling for time of day, pubertal status, and medication use revealed significant Group×SCI Phase interactions for salivary AA (sAA), but not for cortisol. The results did not differ by sex. For analyses with physical victimization/aggression, aggressive and nonaggressive victims showed increases in sAA during the SCI, nonvictimized aggressors showed a decrease, and the normative contrast group did not show any change. For analyses with relational victimization/aggression, nonaggressive victims were the only group who demonstrated sAA reactivity. Incorporating physiological measures into peer victimization studies may give researchers and clinicians insight into youth’s behavior regulation, and help shape prevention or intervention efforts. PMID:22559136

  1. Chewing Over Physiology Integration (United States)

    Abdulkader, Fernando; Azevedo-Martins, Anna Karenina; de Arcisio Miranda, Manoel; Brunaldi, Kellen


    An important challenge for both students and teachers of physiology is to integrate the differentareas in which physiological knowledge is didactically divided. In developing countries, such an issue is even more demanding, because budget restrictions often affect the physiology program with laboratory classes being the first on the list when it…

  2. Novel Functions of MicroRNA-17-92 Cluster in the Endocrine System. (United States)

    Wan, Shan; Chen, Xiang; He, Yuedong; Yu, Xijie


    MiR-17-92 cluster is coded by MIR17HG in chromosome 13, which is highly conserved in vertebrates. Published literatures have proved that miR-17-92 cluster critically regulates tumorigenesis and metastasis. Recent researches showed that the miR-17-92 cluster also plays novel functions in the endocrine system. To summarize recent findings on the physiological and pathological roles of miR-17-92 cluster in bone, lipid and glucose metabolisms. MiR-17-92 cluster plays significant regulatory roles in bone development and metabolism through regulating the differentiation and function of osteoblasts and osteoclasts. In addition, miR-17- 92 cluster is nearly involved in every aspect of lipid metabolism. Last but not the least, the miR-17-92 cluster is closely bound up with pancreatic beta cell function, development of type 1 diabetes and insulin resistance. However, whether miR-17-92 cluster is involved in the communication among bone, fat and glucose metabolisms remains unknown. Growing evidence indicates that miR-17-92 cluster plays significant roles in bone, lipid and glucose metabolisms through a variety of signaling pathways. Fully understanding its modulating mechanisms may necessarily facilitate to comprehend the clinical and molecule features of some metabolic disorders such as osteoporosis, arthrosclerosis and diabetes mellitus. It may provide new drug targets to prevent and cure these disorders. Copyright© Bentham Science Publishers; For any queries, please email at

  3. Society Catalog Information - Society Catalog | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available n DOI 10.18908/lsdba.nbdc00963-001 Description of data contents Information of the academic societies in Jap...tion URL Website URL for the society Name Society name Abbreviation Abbreviation for the societ...y name Class Classification for the society Membership fee Membership fee Academy remarks for the academic journal published by the society Academic journal: Language of text Language of text for

  4. Implementing sponge physiological and genomic information to enhance the diversity of its culturable associated bacteria. (United States)

    Lavy, Adi; Keren, Ray; Haber, Markus; Schwartz, Inbar; Ilan, Micha


    In recent years new approaches have emerged for culturing marine environmental bacteria. They include the use of novel culture media, sometimes with very low-nutrient content, and a variety of growth conditions such as temperature, oxygen levels, and different atmospheric pressures. These approaches have largely been neglected when it came to the cultivation of sponge-associated bacteria. Here, we used physiological and environmental conditions to reflect the environment of sponge-associated bacteria along with genomic data of the prominent sponge symbiont Candidatus Poribacteria sp. WGA-4E, to cultivate bacteria from the Red Sea sponge Theonella swinhoei. Designing culturing conditions to fit the metabolic needs of major bacterial taxa present in the sponge, through a combined use of diverse culture media compositions with aerobic and microaerophilic states, and addition of antibiotics, yielded higher diversity of the cultured bacteria and led to the isolation of novel sponge-associated and sponge-specific bacteria. In this work, 59 OTUs of six phyla were isolated. Of these, 22 have no close type strains at the species level (< 97% similarity of 16S rRNA gene sequence), representing novel bacteria species, and some are probably new genera and even families. © 2013 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved.

  5. The uncivilized society of Czechoslovak tramps. An exploration in proletarian fantasy

    Czech Academy of Sciences Publication Activity Database

    Feinberg, Joseph Grim


    Roč. 3, č. 2 (2017), s. 30-50 E-ISSN 2336-6699 R&D Projects: GA ČR(CZ) GA17-23955S Institutional support: RVO:67985955 Keywords : back-to-nature movements * civil society * anti- politics * Czech tramping * Czech tramps * Czechoslovakia Subject RIV: AA - Philosophy ; Religion OBOR OECD: Antropology, ethnology

  6. Scanpath-based analysis of objects conspicuity in context of human vision physiology. (United States)

    Augustyniak, Piotr


    This paper discusses principal aspects of objects conspicuity investigated with use of an eye tracker and interpreted on the background of human vision physiology. Proper management of objects conspicuity is fundamental in several leading edge applications in the information society like advertisement, web design, man-machine interfacing and ergonomics. Although some common rules of human perception are applied since centuries in the art, the interest of human perception process is motivated today by the need of gather and maintain the recipient attention by putting selected messages in front of the others. Our research uses the visual tasks methodology and series of progressively modified natural images. The modifying details were attributed by their size, color and position while the scanpath-derived gaze points confirmed or not the act of perception. The statistical analysis yielded the probability of detail perception and correlations with the attributes. This probability conforms to the knowledge about the retina anatomy and perception physiology, although we use noninvasive methods only.

  7. Phosphorus physiological ecology and molecular mechanisms in marine phytoplankton. (United States)

    Lin, Senjie; Litaker, Richard Wayne; Sunda, William G


    Phosphorus (P) is an essential nutrient for marine phytoplankton and indeed all life forms. Current data show that P availability is growth-limiting in certain marine systems and can impact algal species composition. Available P occurs in marine waters as dissolved inorganic phosphate (primarily orthophosphate [Pi]) or as a myriad of dissolved organic phosphorus (DOP) compounds. Despite numerous studies on P physiology and ecology and increasing research on genomics in marine phytoplankton, there have been few attempts to synthesize information from these different disciplines. This paper is aimed to integrate the physiological and molecular information on the acquisition, utilization, and storage of P in marine phytoplankton and the strategies used by these organisms to acclimate and adapt to variations in P availability. Where applicable, we attempt to identify gaps in our current knowledge that warrant further research and examine possible metabolic pathways that might occur in phytoplankton from well-studied bacterial models. Physical and chemical limitations governing cellular P uptake are explored along with physiological and molecular mechanisms to adapt and acclimate to temporally and spatially varying P nutrient regimes. Topics covered include cellular Pi uptake and feedback regulation of uptake systems, enzymatic utilization of DOP, P acquisition by phagotrophy, P-limitation of phytoplankton growth in oceanic and coastal waters, and the role of P-limitation in regulating cell size and toxin levels in phytoplankton. Finally, we examine the role of P and other nutrients in the transition of phytoplankton communities from early succession species (diatoms) to late succession ones (e.g., dinoflagellates and haptophytes). © 2015 Phycological Society of America.

  8. Lower Urinary Tract Urological Abnormalities and Urodynamic Findings of Physiological Urinary Incontinence Versus Non-mono Symptomatic Nocturnal Enuresis in Children. (United States)

    Naseri, Mitra


    Although 98% of children attain daytime bladder control by three years of age, urinary incontinence is regarded physiological up to the fifth year of life. This study aimed to assess whether lower urinary tract urological abnormalities and abnormal urodynamic findings are infrequent in children with physiological urinary incontinence in contrast to those with non-monosymptomatic nocturnal enuresis (NMNE). During a three-year period (2007-2009), 66 neurologically normal children including 51 children (34 girls, 17 boys) older than five years of age with NMNE and intermittent daytime incontinence, and 15 children with physiological urinary incontinence (eight girls and seven boys) aged four to five years of age without any known urological abnormalities were enrolled in the study. Patients with neurologic deficits or known urological anomalies were excluded from the study. Kidney-bladder ultrasonography, voiding cystourethrography (VCUG), and urodynamic studies were performed to evaluate the anatomy of urinary tract and bladder function. Urinary tract infection was found in 23 (34.8%) children, 17 (33.3%) and 6 (40%) patients with NMNE and physiological urinary incontinence, respectively. Out of 48 patients who underwent VCUG, vesicoureteral reflux (VUR) was found in seven and eight children younger and older than five years of age, respectively. Abnormal urodynamic findings were reported in 5 (62.5%) of eight children younger than five-year-old, and 14 (63.6%) of 22 patients older than 5-year-old. VUR might be more frequent in children with physiological urinary incontinence than the normal population, and might be as common as NMNE with intermittent daytime incontinence.

  9. Interactions between sleep, stress, and metabolism: From physiological to pathological conditions

    Directory of Open Access Journals (Sweden)

    Camila Hirotsu


    Full Text Available Poor sleep quality due to sleep disorders and sleep loss is highly prevalent in the modern society. Underlying mechanisms show that stress is involved in the relationship between sleep and metabolism through hypothalamic–pituitary–adrenal (HPA axis activation. Sleep deprivation and sleep disorders are associated with maladaptive changes in the HPA axis, leading to neuroendocrine dysregulation. Excess of glucocorticoids increase glucose and insulin and decrease adiponectin levels. Thus, this review provides overall view of the relationship between sleep, stress, and metabolism from basic physiology to pathological conditions, highlighting effective treatments for metabolic disturbances.

  10. The academic impact of the Triological Society theses--Mosher and Fowler awards: citations, impact factor, and h-index. (United States)

    Badran, Karam W; Lahham, Sari; Mahboubi, Hossein; Crumley, Roger L; Wong, Brian J F


    The Triological Society requires thesis submission for full membership. Accepted theses (AT) may be recognized with designations of: Mosher Awards (MA), Fowler Awards (FA), Honorable Mention for Basic Science (HMBS), and Honorable Mention for Clinical Science (HMCS). We sought to determine and compare the scholarly impact of Triological Society theses, their authors, and whether differences exist between AT and those that receive special recognition. Retrospective analysis of awards and theses compiled by The Triological Society home office from 1998 to 2011. Thomson Reuters' Integrated Search Interface (ISI) Web of Knowledge and Google Scholar and were used to determine citations and the author's h-index. Trend and statistical analysis was performed. Of the 307 Triological Society theses examined, 275 were published and had record of citation. H-indices and number of citations were found to be nonparametric; thus, median and quartile (1(st) -3(rd) quartiles) values were found to be the following: AT 11 (4-26), MA 18 (9-25), FA 6 (1-28), HMBS 11 (4-26), and HMCS 16 (1-28) for number of citations per published thesis. H-indices of authors with accepted theses were AT 15 (10-19), MA 16 (15-23), FA 18 (10-23), HMBS 16 (11-19), and HMCS 15 (11-21). When comparing all groupings of theses and award winners with bibliometric indices, no statistical significance was found (P >0.5). The Triological Society cultivates a competitive pool of applicants as membership is highly regarded. Negligible difference in citations and author h-index were observed between AT, MA, and FA theses indicated that the level of excellence is uniform, and thesis submission remains influential and prestigious. Copyright © 2013 The American Laryngological, Rhinological and Otological Society, Inc.

  11. Branched-chain amino acid catabolism is a conserved regulator of physiological ageing. (United States)

    Mansfeld, Johannes; Urban, Nadine; Priebe, Steffen; Groth, Marco; Frahm, Christiane; Hartmann, Nils; Gebauer, Juliane; Ravichandran, Meenakshi; Dommaschk, Anne; Schmeisser, Sebastian; Kuhlow, Doreen; Monajembashi, Shamci; Bremer-Streck, Sibylle; Hemmerich, Peter; Kiehntopf, Michael; Zamboni, Nicola; Englert, Christoph; Guthke, Reinhard; Kaleta, Christoph; Platzer, Matthias; Sühnel, Jürgen; Witte, Otto W; Zarse, Kim; Ristow, Michael


    Ageing has been defined as a global decline in physiological function depending on both environmental and genetic factors. Here we identify gene transcripts that are similarly regulated during physiological ageing in nematodes, zebrafish and mice. We observe the strongest extension of lifespan when impairing expression of the branched-chain amino acid transferase-1 (bcat-1) gene in C. elegans, which leads to excessive levels of branched-chain amino acids (BCAAs). We further show that BCAAs reduce a LET-363/mTOR-dependent neuro-endocrine signal, which we identify as DAF-7/TGFβ, and that impacts lifespan depending on its related receptors, DAF-1 and DAF-4, as well as ultimately on DAF-16/FoxO and HSF-1 in a cell-non-autonomous manner. The transcription factor HLH-15 controls and epistatically synergizes with BCAT-1 to modulate physiological ageing. Lastly and consistent with previous findings in rodents, nutritional supplementation of BCAAs extends nematodal lifespan. Taken together, BCAAs act as periphery-derived metabokines that induce a central neuro-endocrine response, culminating in extended healthspan.

  12. CNS proceedings of the 16. annual conference, volume I and II

    Energy Technology Data Exchange (ETDEWEB)

    Wight, A L; Loewer, R [eds.


    The proceedings of the 16. annual conference of the Canadian Nuclear Society cover a wide range of nuclear topics, but the emphasis is on CANDU reactors and Canadian experience. The 82 papers are arranged in 16 sessions dealing with the following subjects: thermalhydraulics, containment, control and instrumentation, reactor physics, fuel channels, engineering and maintenance, safety and licensing, severe accidents and probabilistic safety assessment, new reactors and applications, radiation, fuel, computers. The individual papers have been abstracted separately.

  13. CNS proceedings of the 16. annual conference, volume I and II

    International Nuclear Information System (INIS)

    Wight, A.L.; Loewer, R.


    The proceedings of the 16. annual conference of the Canadian Nuclear Society cover a wide range of nuclear topics, but the emphasis is on CANDU reactors and Canadian experience. The 82 papers are arranged in 16 sessions dealing with the following subjects: thermalhydraulics, containment, control and instrumentation, reactor physics, fuel channels, engineering and maintenance, safety and licensing, severe accidents and probabilistic safety assessment, new reactors and applications, radiation, fuel, computers. The individual papers have been abstracted separately

  14. Mass of 17O from Penning-trap mass spectrometry and molecular spectroscopy: A precision test of the Dunham-Watson model in carbon monoxide

    International Nuclear Information System (INIS)

    Mount, Brianna J.; Redshaw, Matthew; Myers, Edmund G.; Mueller, Holger S. P.


    By fitting the Dunham-Watson model to extensive rotational and vibrational spectroscopic data of isotopic variants of CO, and by using existing precise masses of 13 C, 16 O, and 18 O from Penning-trap mass spectrometry, we determine the atomic mass of 17 O to be M[ 17 O]=16.999 131 644(30) u, where the uncertainty is purely statistical. Using Penning-trap mass spectrometry, we have also directly determined the atomic mass of 17 O with the more precise result M[ 17 O]=16.999 131 756 6(9) u. The Dunham-Watson model applied to the molecular spectroscopic data hence predicts the mass of 17 O to better than 1 part in 10 8 .

  15. Gadolinium heteropoly complex K 17[Gd(P 2W 17O 61) 2] as a potential MRI contrast agent (United States)

    Sun, Guoying; Feng, Jianghua; Wu, Huifeng; Pei, Fengkui; Fang, Ke; Lei, Hao


    Gadolinium heteropoly complex K17[Gd(P2W17O61)2] has been evaluated by in vitro and in vivo experiments as a potential contrast agent for magnetic resonance imaging (MRI). The thermal analysis and conductivity study indicate that this complex has good thermal stability and wide pH stability range. The T1 relaxivity is 7.59 mM-1 s-1 in aqueous solution and 7.97 mM-1 s-1 in 0.725 mmol l-1 bovine serum albumin (BSA) solution at 25 °C and 9.39 T, respectively. MR imaging of three male Sprague-Dawley rats showed remarkable enhancement in rat liver after intravenous injection, which persisted longer than with Gd-DTPA. The signal intensity increased by 57.1±16.9% during the whole imaging period at 0.082 mmol kg-1dose. Our preliminary in vitro and in vivo studies indicate that K17[Gd(P2W17O61)2] is a potential liver-specific MRI contrast agent.

  16. Investigations of neutron-rich nuclei at the dripline through their analogue states : The cases of $^{10}$Li - $^{10}$Be (T=2) and $^{17}$C - $^{17}$N (T=5/2)

    CERN Multimedia


    We propose to study the elastic resonance scattering reactions $^{9}$Li+p and $^{16}$C+p to investigate the energies, spins and parities of the lowest T=2 states in $^{10}$Be and the T=5/2 states in $^{17}$N. These are analogue states of the ground states and first excited states in $^{10}$Li and $^{17}$C.

  17. Functional evaluation of the role of C-type lectin domain family 16A at the chromosome 16p13 locus. (United States)

    Zouk, H; D'Hennezel, E; Du, X; Ounissi-Benkalha, H; Piccirillo, C A; Polychronakos, C


    The type 1 diabetes-associated 16p13 locus contains the CLEC16A gene. Its preferential immune cell expression suggests involvement in autoimmunity. Given its elevated expression in dendritic and B cells - known professional antigen-presenting cells (APCs) - we hypothesize that C-type lectin domain family 16 member A (CLEC16A) may be involved in T cell co-stimulation and consequent activation and proliferation. We also sought to identify CLEC16A's subcellular localization. The effect of the CLEC16A knock-down (KD) on B cell co-stimulation and activation of T cells was tested in human lymphoblastoid cell lines (LCLs) by co-culture with CD4(+) T cells. T cell activation and proliferation were determined by flow-cytometric analysis of CD69 and CD25 expression and carboxyfluorescein succinimidyl ester (CFSE) dilution, respectively. CLEC16A subcellular localization in K562 cells was examined by immunofluorescence. We show that the CLEC16A KD did not affect the tested indices of lymphoblastoid cell line (LCL) APC capacity. Additionally, the percentage of activated T cells following LCL co-culture was not affected significantly by the CLEC16A KD. T cells co-cultured with KD or control LCLs also exhibited similar cell division profiles. CLEC16A co-localized with an endoplasmic reticulum (ER) marker, suggesting that it may be an ER protein. In conclusion, CLEC16A may not be involved in T cell co-stimulation. Additional studies on CLEC16A, accounting for its ER localization, are needed to uncover its biological role. © 2013 British Society for Immunology.

  18. 17th Radiochemical conference: RadChem 2014 Marianske Lazne, 11-16th May 2014

    Czech Academy of Sciences Publication Activity Database

    John, J.; Kučera, Jan; Vobecký, Miloslav; Mizera, Jiří; Špendlíková, I.


    Roč. 304, č. 1 (2015), s. 1-6 ISSN 0236-5731 Institutional support: RVO:68081715 ; RVO:61389005 Keywords : DNC FNSPE CTU * NRC * DNRC EuCheMS * IUPAC Subject RIV: CH - Nuclear ; Quantum Chemistry; CB - Analytical Chemistry, Separation (UIACH-O) Impact factor: 0.983, year: 2015

  19. Cactus stem (Opuntia ficus-indica Mill): anatomy, physiology and chemical composition with emphasis on its biofunctional properties. (United States)

    Ventura-Aguilar, Rosa Isela; Bosquez-Molina, Elsa; Bautista-Baños, Silvia; Rivera-Cabrera, Fernando


    Cactus stem (Opuntia ficus-indica Mill) is native to Mesoamerica and marketed in different forms such as fresh, frozen or pre-cooked. Worldwide, this vegetable is recognized for its pharmaceutical actions, including its antioxidant, diuretic, anticarcinogenic, anti-inflammatory, anti-diabetic, and anti-hypercholesterolemic properties, as well as their antiviral and antispermatogenic effects. However, not all of these properties have been associated with its chemical composition; therefore, this review aims to present and integrate information available on the physiology and anatomy of cactus stem and its chemical composition, focusing on some of the many factors that determine its biofunctionality. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  20. An overview of artificial gravity. [effects on human performance and physiology (United States)

    Stone, R. W., Jr.


    The unique characteristics of artificial gravity that affect human performance and physiology in an artificial gravity environment are reviewed. The rate at which these unique characteristics change decreases very rapidly with increasing radius of a rotating vehicle used to produce artificial gravity. Reducing their influence on human performance or physiology by increasing radius becomes a situation of very rapidly diminishing returns. A review of several elements of human performance has developed criteria relative to the sundry characteristics of artificial gravity. A compilation of these criteria indicates that the maximum acceptable rate of rotation, leg heaviness while walking, and material handling are the factors that define the minimum acceptable radius. The ratio of Coriolis force to artificial weight may also be significant. Based on current knowledge and assumptions for the various criteria, a minimum radius between 15.2 and 16.8 m seems desirable.

  1. A beginner's guide to nutritional profiling in physiology and ecology. (United States)

    Frost, Paul C; Song, Keunyea; Wagner, Nicole D


    The nutritional history of an organism is often difficult to ascertain. Nonetheless, this information on past diet can be particularly important when explaining the role of nutrition in physiological responses and ecological dynamics. One approach to infer the past dietary history of an individual is through characterization of its nutritional phenotype, an interrelated set of molecular and physiological properties that are sensitive to dietary stress. Comparisons of nutritional phenotypes between a study organism and reference phenotypes have the potential to provide insight into the type and intensity of past dietary constraints. Here, we describe this process of nutritional profiling for ecophysiological research in which a suite of molecular and physiological responses are cataloged for animals experiencing known types and intensities of dietary stress and are quantitatively compared with those of unknown individuals. We supplement this delineation of the process of nutritional profiling with a first-order analysis of its sensitivity to the number of response variables in the reference database, their responsiveness to diet, and the size of reference populations. In doing so, we demonstrate the considerable promise this approach has to transform future studies of nutrition by its ability to provide more and better information on responses to dietary stress in animals and their populations. © The Author 2014. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email:

  2. Does rapid and physiological astrocyte-neuron signalling amplify epileptic activity? (United States)

    Henneberger, Christian


    The hippocampus is a key brain region in the pathophysiology of mesial temporal lobe epilepsy. Long-term changes of its architecture and function on the network and cellular level are well documented in epilepsy. Astrocytes can control many aspects of neuronal function and their long-term alterations over weeks, months and years play an important role in epilepsy. However, a pathophysiological transformation of astrocytes does not seem to be required for astrocytes to contribute to epileptic activity. Some of the properties of physiological astrocyte-neuron communication could allow these cells to exacerbate or synchronize neuronal firing on shorter time scales of milliseconds to minutes. Therefore, these astrocyte-neuron interactions are increasingly recognized as potential contributors to epileptic activity. Fast and reciprocal communication between astrocytes and neurons is enabled by a diverse set of mechanisms that could both amplify and counteract epileptic activity. They may thus promote or cause development of epileptic activity or inhibit it. Mechanisms of astrocyte-neuron interactions that can quickly increase network excitability involve, for example, astrocyte Ca 2+ and Na + signalling, K + buffering, gap junction coupling and metabolism. However, rapid changes of astrocyte neurotransmitter uptake and morphology may also underlie or support development of network hyperexcitability. The temporal characteristics of these interactions, their ability to synchronize neuronal activity and their net effect on network activity will determine their contribution to the emergence or maintenance of epileptic activity. © 2016 The Authors. The Journal of Physiology © 2016 The Physiological Society.

  3. Analysis of autism susceptibility gene loci on chromosomes 1p, 4p, 6q, 7q, 13q, 15q, 16p, 17q, 19q and 22q in Finnish multiplex families. (United States)

    Auranen, M; Nieminen, T; Majuri, S; Vanhala, R; Peltonen, L; Järvelä, I


    The role of genetic factors in the etiology of the autistic spectrum of disorders has clearly been demonstrated. Ten chromosomal regions, on chromosomes 1p, 4p, 6q, 7q, 13q, 15q, 16p, 17q, 19q and 22q have potentially been linked to autism.1-8 We have analyzed these chromosomal regions in a total of 17 multiplex families with autism originating from the isolated Finnish population by pairwise linkage analysis and sib-pair analysis. Mild evidence for putative contribution was found only with the 1p chromosomal region in the susceptibility to autism. Our data suggest that additional gene loci exist for autism which will be detectable in and even restricted to the isolated Finnish population.

  4. African Journal for Physical Activity and Health Sciences - Vol 16 ...

    African Journals Online (AJOL)

    Dance and music as mediums for the social integration of children with intellectual disabilities into mainstream society · EMAIL FULL TEXT EMAIL FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. A Sooful, J Surujlal, M Dhurup. ...

  5. Neural Plasticity Is Involved in Physiological Sleep, Depressive Sleep Disturbances, and Antidepressant Treatments

    Directory of Open Access Journals (Sweden)

    Meng-Qi Zhang


    Full Text Available Depression, which is characterized by a pervasive and persistent low mood and anhedonia, greatly impacts patients, their families, and society. The associated and recurring sleep disturbances further reduce patient’s quality of life. However, therapeutic sleep deprivation has been regarded as a rapid and robust antidepressant treatment for several decades, which suggests a complicated role of sleep in development of depression. Changes in neural plasticity are observed during physiological sleep, therapeutic sleep deprivation, and depression. This correlation might help us to understand better the mechanism underlying development of depression and the role of sleep. In this review, we first introduce the structure of sleep and the facilitated neural plasticity caused by physiological sleep. Then, we introduce sleep disturbances and changes in plasticity in patients with depression. Finally, the effects and mechanisms of antidepressants and therapeutic sleep deprivation on neural plasticity are discussed.

  6. A longitudinal study of growth, sex steroids and IGF-1 in boys with physiological gynaecomastia

    DEFF Research Database (Denmark)

    Mieritz, Mikkel G.; Raket, Lars Lau; Hagen, Casper P.


    Context: Physiological gynaecomastia is common and affects a large proportion of otherwise healthy adolescent boys. It is thought to be caused by an imbalance between estrogen and testosterone, though this is rarely evident in analyses of serum. Objective: This study aimed to describe the frequency...... of physiological gynaecomastia, and to determine possible etiological factors (e.g. auxology and serum hormone levels) in a longitudinal set-up. Design, Settings and Participants: A prospective cohort study of 106 healthy Danish boys (5.8–16.4 years) participated in the longitudinal part of “the COPENHAGEN Puberty......, pubertal development and the presence of gynaecomastia were evaluated at each visit. Results: 52 of 106 boys (49 developed gynaecomastia of which 10 (19 presented with intermittent gynaecomastia. Boys with physiological gynaecomastia reached peak height velocity at a significantly younger age than boys who...

  7. Current status of portal vein thrombosis in Japan: Results of a questionnaire survey by the Japan Society for Portal Hypertension. (United States)

    Kojima, Seiichiro; Watanabe, Norihito; Koizumi, Jun; Kokubu, Shigehiro; Murashima, Naoya; Matsutani, Shoichi; Obara, Katsutoshi


    To investigate the current status of portal vein thrombosis (PVT) in Japan, the Clinical Research Committee of the Japan Society of Portal Hypertension undertook a questionnaire survey. A questionnaire survey of 539 cases of PVT over the previous 10 years was carried out at institutions affiliated with the Board of Trustees of the Japan Society of Portal Hypertension. The most frequent underlying etiology of PVT was liver cirrhosis in 75.3% of patients. Other causes included inflammatory diseases of the hepatobiliary system and the pancreas, malignant tumors, and hematologic diseases. The most frequent site was the main trunk of the portal vein (MPV) in 70.5%, and complete obstruction of the MPV was present in 11.5%. Among the medications for PVT, danaparoid was given to 45.8%, warfarin to 26.2%, heparin to 17.3%, and anti-thrombin III to 16.9%. Observation of the course was practiced in 22.4%. Factors contributing to therapeutic efficacy were implementation of various medications, thrombi localized to either the right or left portal vein only, non-complete obstruction of the MPV and Child-Pugh class A liver function. A survival analysis showed that the prognosis was favorable with PVT disappearance regardless of treatment. The questionnaire survey showed the current status of PVT in Japan. Any appropriate medication should be given to a patient with PVT when PVT is recognized. It is necessary to compile a large amount of information and reach a consensus on safe and highly effective management of PVT. © 2017 The Japan Society of Hepatology.

  8. "Thinking ethics": a novel, pilot, proof-of-concept program of integrating ethics into the Physiology curriculum in South India. (United States)

    D, Savitha; Vaz, Manjulika; Vaz, Mario


    Integrating medical ethics into the physiology teaching-learning program has been largely unexplored in India. The objective of this exercise was to introduce an interactive and integrated ethics program into the Physiology course of first-year medical students and to evaluate their perceptions. Sixty medical students (30 men, 30 women) underwent 11 sessions over a 7-mo period. Two of the Physiology faculty conducted these sessions (20-30 min each) during the routine physiology (theory/practicals) classes that were of shorter duration and could, therefore, accommodate the discussion of related ethical issues. This exercise was in addition to the separate ethics classes conducted by the Medical Ethics department. The sessions were open ended, student centered, and designed to stimulate critical thinking. The students' perceptions were obtained through a semistructured questionnaire and focused group discussions. The students found the program unique, thought provoking, fully integrated, and relevant. It seldom interfered with the physiology teaching. They felt that the program sensitized them about ethical issues and prepared them for their clinical years, to be "ethical doctors." Neutral observers who evaluated each session felt that the integrated program was relevant to the preclinical year and that the program was appropriate in its content, delivery, and student involvement. An ethics course taught in integration with Physiology curriculum was found to be beneficial, feasible, and compatible with Physiology by students as well as neutral observers. Copyright © 2017 the American Physiological Society.

  9. From Physiology to Prevention: Further remarks on a physiological imperative

    Directory of Open Access Journals (Sweden)

    B Jouanjean


    Full Text Available Physiology, is the fundamental and functional expression of life. It is the study of all the representative functions of Man in all his capacities, and in particular, his capacity to work. It is very possible to establish a link between a physiological and physiopathological state, the capacity of work and the economy, which can be understood as the articulation between the physiological capacities of Man and the production of work. If these functions are innately acquired by Man they are likewise maintained by regulatory functions throughout life. The stability of these regulatory mechanisms represent the state of good health. The management of this state, constitutes Primary Prevention where both chronic and acute physiopathology defines an alteration in these regulatory mechanisms. We deduce from this reasoning that a tripartite management adapted to the physiological situation is viable and that by choosing parameters specific to individual and collective behavior, it is possible to inject, and combine, at each level and to each demand in order to budget a healthcare system in a more balanced and equitable way. 

  10. The Physiology of Female Sexual Function and the Pathophysiology of Female Sexual Dysfunction (Committee 13A). (United States)

    Levin, Roy J; Both, Stephanie; Georgiadis, Janniko; Kukkonen, Tuuli; Park, Kwangsung; Yang, Claire C


    The article consists of six sections written by separate authors that review female genital anatomy, the physiology of female sexual function, and the pathophysiology of female sexual dysfunction but excluding hormonal aspects. To review the physiology of female sexual function and the pathophysiology of female sexual dysfunction especially since 2010 and to make specific recommendations according to the Oxford Centre for evidence based medicine (2009) "levels of evidence" wherever relevant. Recommendations were made for particular studies to be undertaken especially in controversial aspects in all six sections of the reviewed topics. Despite numerous laboratory assessments of female sexual function, genital assessments alone appear insufficient to characterise fully the complete sexual response. Copyright © 2016 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.

  11. 115-year-old society knows how to reach young scientists: ASM Young Ambassador Program. (United States)

    Karczewska-Golec, Joanna


    With around 40,000 members in more than 150 countries, American Society for Microbiology (ASM) faces the challenge of meeting very diverse needs of its increasingly international members base. The newly launched ASM Young Ambassador Program seeks to aid the Society in this effort. Equipped with ASM conceptual support and financing, Young Ambassadors (YAs) design and pursue country-tailored approaches to strengthen the Society's ties with local microbiological communities. In a trans-national setting, the active presence of YAs at important scientific events, such as 16th European Congress on Biotechnology, forges new interactions between ASM and sister societies. The paper presents an overview of the Young Ambassadors-driven initiatives at both global and country levels, and explores the topic of how early-career scientists can contribute to science diplomacy and international relations. Copyright © 2014 Elsevier B.V. All rights reserved.

  12. 16α-[77Br]bromoestradiol-17β: a high specific-activity, gamma-emitting tracer with uptake in rat uterus and induced mammary tumors

    International Nuclear Information System (INIS)

    Katzenellenbogen, J.A.; Senderoff, S.G.; McElvany, K.D.; O'Brien, H.A. Jr.; Welch, M.J.


    16α-[ 77 Br]bromoestradiol-17β (compound 1) has been synthesized by radiobromination of estrone enoldiacetate. Tissue uptake studies performed 1 hr after administration of compound 1 to immature or mature female rats showed uterus-to-blood ratios of 13, with nontarget tissue-to-blood ratios ranging from 0.6 to 2. Co-administration of unlabeled estradiol caused a selective depression in the uterine uptake with no effect on nontarget tissue uptake. In adult animals bearing adenocarcinomas induced by DMBA (7,12-dimethylbenz(a)anthracene), tumor-to-blood ratios of 6.3 were obtained, this uptake also being depressed in animals treated with unlabeled estradiol. The studies demonstrate that compound 1 has suitable binding properties and sufficiently high specific activity so that its uptake in estrogen target tissues in vivo is mediated primarily by the estrogen receptor. Furthermore, they suggest that this compound may be suitable for imaging human breast tumors that contain estrogen receptors

  13. The Information Society

    Directory of Open Access Journals (Sweden)

    Hiranya Nath


    Full Text Available This article briefly discusses various definitions and concepts of the so-called information society. The term information society has been proposed to refer to the post-industrial society in which information plays a pivotal role. The definitions that have been proposed over the years highlight five underlying characterisations of an information society: technological, economic, sociological, spatial, and cultural. This article discusses those characteristics. While the emergence of an information society may be just a figment of one’s imagination, the concept could be a good organising principle to describe and analyse the changes of the past 50 years and of the future in the 21st century.

  14. Autism Society (United States)

    ... Español Improving the lives of all affected by autism. The Autism Society is the nation's leading grassroots ... more Improving the lives of all affected by autism. The Autism Society is the nation's leading grassroots ...

  15. Visible implant elastomer (VIE) tagging and simulated predation risk elicit similar physiological stress responses in three-spined stickleback Gasterosteus aculeatus. (United States)

    Fürtbauer, I; King, A J; Heistermann, M


    The effect of visible implant elastomer (VIE) tagging on the immediate physiological stress response was tested in female three-spined stickleback Gasterosteus aculeatus, using non-invasive waterborne cortisol analysis. Post-tagging cortisol levels were significantly higher compared with pretreatment baseline concentrations; however, when comparing post-tagging cortisol levels with cortisol levels after exposure to a simulated aerial predator, no significant differences were found. This study indicates that VIE tagging elicits a physiological stress response similar to those occurring in the everyday lives of this important biological model organism. © 2015 The Fisheries Society of the British Isles.

  16. Na+ -K+ -2Cl- Cotransporter (NKCC) Physiological Function in Nonpolarized Cells and Transporting Epithelia. (United States)

    Delpire, Eric; Gagnon, Kenneth B


    Two genes encode the Na + -K + -2Cl - cotransporters, NKCC1 and NKCC2, that mediate the tightly coupled movement of 1Na + , 1K + , and 2Cl - across the plasma membrane of cells. Na + -K + -2Cl - cotransport is driven by the chemical gradient of the three ionic species across the membrane, two of them maintained by the action of the Na + /K + pump. In many cells, NKCC1 accumulates Cl - above its electrochemical potential equilibrium, thereby facilitating Cl - channel-mediated membrane depolarization. In smooth muscle cells, this depolarization facilitates the opening of voltage-sensitive Ca 2+ channels, leading to Ca 2+ influx, and cell contraction. In immature neurons, the depolarization due to a GABA-mediated Cl - conductance produces an excitatory rather than inhibitory response. In many cell types that have lost water, NKCC is activated to help the cells recover their volume. This is specially the case if the cells have also lost Cl - . In combination with the Na + /K + pump, the NKCC's move ions across various specialized epithelia. NKCC1 is involved in Cl - -driven fluid secretion in many exocrine glands, such as sweat, lacrimal, salivary, stomach, pancreas, and intestine. NKCC1 is also involved in K + -driven fluid secretion in inner ear, and possibly in Na + -driven fluid secretion in choroid plexus. In the thick ascending limb of Henle, NKCC2 activity in combination with the Na + /K + pump participates in reabsorbing 30% of the glomerular-filtered Na + . Overall, many critical physiological functions are maintained by the activity of the two Na + -K + -2Cl - cotransporters. In this overview article, we focus on the functional roles of the cotransporters in nonpolarized cells and in epithelia. © 2018 American Physiological Society. Compr Physiol 8:871-901, 2018. Copyright © 2018 American Physiological Society. All rights reserved.

  17. The 16th International Geological Congress, Washington, 1933 (United States)

    Nelson, C.M.


    In 1933, the International Geological Congress (IGC) returned to the United States of America (USA) for its sixteenth meeting, forty-two years after the 5th IGC convened in Washington. The Geological Society of America and the U.S. Geological Survey (USGS) supplied the major part of the required extra-registration funding after the effects of the Great Depression influenced the 72th U.S. Congress not to do so. A reported 1, 182 persons or organizations, representing fifty-four countries, registered for the 16 th IGC and thirty-four countries sent 141 official delegates. Of the total number of registrants, 665 actually attended the meeting; 500 came from the USA; and fifteen had participated in the 5th IGC. The 16 th Meeting convened in the U.S. Chamber of Commerce Building from 22 to 29 July. The eighteen half-day scientific sections-orogenesis (four), major divisions of the Paleozoic (three), miscellaneous (three), batholiths and related intrusives (two), arid-region geomorphic processes and products (one), fossil man and contemporary faunas (one), geology of copper and other ore deposits (one), geology of petroleum (one), measuring geologic time (one), and zonal relations of metalliferous deposits (one)-included 166 papers, of which fifty (including several of the key contributions) appeared only by title. The Geological Society of Washington, the National Academy of Sciences, and the U.S. Bureau of Mines hosted or contributed to evening presentations or receptions. Twenty-eight of the 16th IGC's thirty new guidebooks and one new USGS Bulletin aided eight pre-meeting, seven during-meeting, and four post-meeting field trips of local, regional, or national scope. The remaining two new guidebooks outlined the USA's structural geology and its stratigraphic nomenclature. The 16th IGC published a two-volume monograph on the world's copper resources (1935) and a two-volume report of its proceedings (1936).

  18. Citizenship in civil society?

    NARCIS (Netherlands)

    Ossewaarde, Marinus R.R.


    This article seeks to provide a conceptual framework to complement and guide the empirical analysis of civil society. The core argument is that civil society must be understood, not as a category of (post)industrialized society, but as one of individualized society. Civil society is characterized by

  19. The Endocrine System [and] Instructor's Guide: The Endocrine System. Health Occupations Education Module: Instructional Materials in Anatomy and Physiology for Pennsylvania Health Occupations Programs. (United States)

    National Evaluation Systems, Inc., Amherst, MA.

    This module on the endocrine system is one of 17 modules designed for individualized instruction in health occupations education programs at both the secondary and postsecondary levels. It is part of an eight-unit miniseries on anatomy and physiology within the series of 17 modules. Following a preface which explains to the student how to use the…

  20. 4- states of 16O

    International Nuclear Information System (INIS)

    Barker, F.C.; Smith, R.; Morrison, I.; Amos, K.A.


    A three-state isospin-mixing model is fitted to available data on pion scattering and nucleon pickup relevant to the 4 - states of 16 O at 17.79, 18.98 and 19.80 MeV. An excellent fit to all data is obtained, and the state descriptions are shown to be consistent with inelastic proton scattering measurements. The 18.98 MeV state is predominantly 1p-1h T = 1, while the other two states have significant isospin mixing and 3p-3h admixtures

  1. Positive impact of integrating histology and physiology teaching at a medical school in China. (United States)

    Sherer, Renslow; Wan, Yu; Dong, Hongmei; Cooper, Brian; Morgan, Ivy; Peng, Biwen; Liu, Jun; Wang, Lin; Xu, David


    To modernize its stagnant, traditional curriculum and pedagogy, the Medical School of Wuhan University in China adopted (with modifications) the University of Chicago's medical curriculum model. The reform effort in basic sciences was integrating histology and physiology into one course, increasing the two subjects' connection to clinical medicine, and applying new pedagogies and assessment methods. This study assessed the results of the reform by comparing the attitudes and academic achievements of students in the reform curriculum (n = 41) and their traditional curriculum peers (n = 182). An attitude survey was conducted to obtain students' views of their respective histology and physiology instruction. Survey items covered lectures, laboratory teaching, case analyses and small-group case discussions, assessment of students, and overall quality of the courses and instruction. A knowledge test consisting of questions from three sources was given to measure students' mastery of topics that they had learned. Results showed that reform curriculum students were rather satisfied with their course and new teaching methods in most cases. When these students' attitudes were compared with those of their traditional curriculum peers, several significant differences favoring the reform were identified regarding physiology teaching. No other significant difference was found for physiology or histology teaching. Reform curriculum students outperformed their peers on four of five subcategories of the knowledge test questions. These findings support the benefits of integration and state-of-the-art teaching methods. Our study may offer lessons to medical schools in China and other countries whose medical education is in need of change. Copyright © 2014 The American Physiological Society.

  2. Iron Deficiency in Seagrasses and Macroalgae in the Red Sea Is Unrelated to Latitude and Physiological Performance

    KAUST Repository

    Anton, Andrea; Hendriks, Iris E.; Marbà , Nú ria; Krause-Jensen, Dorte; Garcias Bonet, Neus; Duarte, Carlos M.


    Iron can limit primary production in shallow marine systems, especially in tropical waters characterized by carbonated sediments, where iron is largely trapped in a non-available form. The Red Sea, an oligotrophic ecosystem characterized by a strong N-S latitudinal nutrient gradient, is a suitable setting to explore patterns in situ of iron limitation in macrophytes and their physiological performance under different iron regimes. We assessed the interactions between environmental gradients and physiological parameters of poorly-studied Red Sea macrophytes. Iron concentration, chlorophyll a concentration, blade thickness, and productivity of 17 species of macrophytes, including seven species of seagrasses and 10 species of macroalgae, were measured at 21 locations, spanning 10 latitude degrees, along the Saudi Arabian coast. Almost 90% of macrophyte species had iron concentrations below the levels indicative of iron sufficiency and more than 40% had critically low iron concentrations, suggesting that iron is a limiting factor of primary production throughout the Red Sea. We did not identify relationships between tissue iron concentration, chlorophyll a concentration and physiological performance of the 17 species of seagrass and macroalgae. There was also no latitudinal pattern in any of the parameters studied, indicating that the South to North oligotrophication of the Red Sea is not reflected in iron concentration, chlorophyll a concentration or productivity of Red Sea macrophytes.

  3. Iron Deficiency in Seagrasses and Macroalgae in the Red Sea Is Unrelated to Latitude and Physiological Performance

    KAUST Repository

    Anton, Andrea


    Iron can limit primary production in shallow marine systems, especially in tropical waters characterized by carbonated sediments, where iron is largely trapped in a non-available form. The Red Sea, an oligotrophic ecosystem characterized by a strong N-S latitudinal nutrient gradient, is a suitable setting to explore patterns in situ of iron limitation in macrophytes and their physiological performance under different iron regimes. We assessed the interactions between environmental gradients and physiological parameters of poorly-studied Red Sea macrophytes. Iron concentration, chlorophyll a concentration, blade thickness, and productivity of 17 species of macrophytes, including seven species of seagrasses and 10 species of macroalgae, were measured at 21 locations, spanning 10 latitude degrees, along the Saudi Arabian coast. Almost 90% of macrophyte species had iron concentrations below the levels indicative of iron sufficiency and more than 40% had critically low iron concentrations, suggesting that iron is a limiting factor of primary production throughout the Red Sea. We did not identify relationships between tissue iron concentration, chlorophyll a concentration and physiological performance of the 17 species of seagrass and macroalgae. There was also no latitudinal pattern in any of the parameters studied, indicating that the South to North oligotrophication of the Red Sea is not reflected in iron concentration, chlorophyll a concentration or productivity of Red Sea macrophytes.

  4. Antifungal activity of rimocidin and a new rimocidin derivative BU16 produced by Streptomyces mauvecolor BU16 and their effects on pepper anthracnose. (United States)

    Jeon, B J; Kim, J D; Han, J W; Kim, B S


    The objective of this study was to explore antifungal metabolites targeting fungal cell envelope and to evaluate the control efficacy against anthracnose development in pepper plants. A natural product library comprising 3000 microbial culture extracts was screened via an adenylate kinase (AK)-based cell lysis assay to detect antifungal metabolites targeting the cell envelope of plant-pathogenic fungi. The culture extract of Streptomyces mauvecolor strain BU16 displayed potent AK-releasing activity. Rimocidin and a new rimocidin derivative, BU16, were identified from the extract as active constituents. BU16 is a tetraene macrolide containing a six-membered hemiketal ring with an ethyl group side chain instead of the propyl group in rimocidin. Rimocidin and BU16 showed broad-spectrum antifungal activity against various plant-pathogenic fungi and demonstrated potent control efficacy against anthracnose development in pepper plants. Antifungal metabolites produced by S. mauvecolor strain BU16 were identified to be rimocidin and BU16. The compounds displayed potent control efficacy against pepper anthracnose. Rimocidin and BU16 would be active ingredients of disease control agents disrupting cell envelope of plant-pathogenic fungi. The structure and antifungal activity of rimocidin derivative BU16 is first described in this study. © 2016 The Society for Applied Microbiology.

  5. Knowledge on the subject of human physiology among Polish high school students--a cross-sectional study. (United States)

    Zwinczewska, Helena; Rozwadowska, Joanna; Traczyk, Anna; Majda, Szymon; Wysocki, Michał; Grabowski, Kamil; Kopeć, Sylwia; Głowacki, Roman; Węgrzyn, Katarzyna; Tomaszewski, Krzysztof A; Walocha, Jerzy A


    In most cases the only knowledge an individual will receive with regards to their own body and its proper functioning is during their high school education. The aim of this study was to evaluate high school students' knowledge about basic physiology. The research was carried out in five, randomly chosen high schools in Krakow, Poland. Young people in the age of 17-19 years were asked to fill in the questionnaire designed by the authors. The first part of the survey included personal data. The second part contained 20 close-ended questions assessing students' knowledge about the basics of human physiology. Question difficulty varied from easy through average, and up to difficult. The maximum number of points to achieve was 20. One-thousand-and eighty-three (out of 1179 invited--91.86%) Polish high school students (63.25% female) filled in a 20-item questionnaire constructed by the authors regarding basic human physiology. The mean age of the group was 17.66 ± 0.80 years. The mean score among the surveyed was 10.15 ± 3.48 (range 0-20). Only 26.04% of students achieved a grade of 60% or more, and only one person obtained the highest possible score. Females achieved significantly better scores than males (10.49 ± 3.38 vs. 9.56 ± 3.56; p physiology, obtained better results than those in their third year who had already finished the biology course (10.70 ± 3.27 vs. 9.81 ± 3.74 respectively; p physiology (10.70 ± 3.27 vs. 9.63 ± 2.74 respectively; p = 0.003). Over 23% of students did not know that mature red blood cells do not have cell nuclei and a similar number of them answered that humans have 500,000 erythrocytes in 1 mm3 of blood. Over 32% believed that plasma does not participate in the transport of respiratory gases, and 31% believed that endocrine glands secrete hormones within their immediate vicinity and into the blood. Our research has shown that young people, especially men, often lack basic physiological knowledge needed to make conscious and

  6. Requirement of TPO/c-mpl for IL-17A-induced granulopoiesis and megakaryopoiesis. (United States)

    Tan, Weihong; Liu, Bainan; Barsoum, Adel; Huang, Weitao; Kolls, Jay K; Schwarzenberger, Paul


    IL-17A is a critical, proinflammatory cytokine essential to host defense and is induced in response to microbial invasion. It stimulates granulopoiesis, leading to neutrophilia, neutrophil activation, and mobilization. TPO synergizes with other cytokines in stimulating and expanding hematopoietic progenitors, also leading to granulopoiesis and megakaryopoiesis, and is required for thrombocytopoiesis. We investigated the effects of in vivo expression of IL-17A on granulopoiesis and megakaryopoiesis in TPO receptor c-mpl-/- mice. IL-17A expression expanded megakaryocytes by 2.5-fold in normal mice but had no such effect in c-mpl-/- mice. The megakaryocyte expansion did not result in increased peripheral platelet counts. IL-17A expression did not impact bone marrow precursors in c-mpl-/- mice; however, it expanded splenic precursors, although to a lesser extent compared with normal controls (CFU-HPP). No peripheral neutrophil expansion was observed in c-mpl-/- mice. Moreover, in c-mpl-/- mice, release of IL-17A downstream cytokines was reduced significantly (KC, MIP-2, GM-CSF). The data suggest that IL-17A requires the presence of functional TPO/c-mpl to exert its effects on granulopoiesis and megakaryopoiesis. Furthermore, IL-17A and its downstream cytokines are important regulators and synergistic factors for the physiologic function of TPO/c-mpl on hematopoiesis.

  7. Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist. (United States)

    Sugawara, Reiko; Lee, Eun-Jung; Jang, Min Seong; Jeun, Eun-Ji; Hong, Chun-Pyo; Kim, Jung-Hwan; Park, Areum; Yun, Chang Ho; Hong, Sung-Wook; Kim, You-Me; Seoh, Ju-Young; Jung, YunJae; Surh, Charles D; Miyasaka, Masayuki; Yang, Bo-Gie; Jang, Myoung Ho


    Eosinophils play proinflammatory roles in helminth infections and allergic diseases. Under steady-state conditions, eosinophils are abundantly found in the small intestinal lamina propria, but their physiological function is largely unexplored. In this study, we found that small intestinal eosinophils down-regulate Th17 cells. Th17 cells in the small intestine were markedly increased in the ΔdblGATA-1 mice lacking eosinophils, and an inverse correlation was observed between the number of eosinophils and that of Th17 cells in the small intestine of wild-type mice. In addition, small intestinal eosinophils suppressed the in vitro differentiation of Th17 cells, as well as IL-17 production by small intestinal CD4(+)T cells. Unlike other small intestinal immune cells or circulating eosinophils, we found that small intestinal eosinophils have a unique ability to constitutively secrete high levels of IL-1 receptor antagonist (IL-1Ra), a natural inhibitor of IL-1β. Moreover, small intestinal eosinophils isolated from IL-1Ra-deficient mice failed to suppress Th17 cells. Collectively, our results demonstrate that small intestinal eosinophils play a pivotal role in the maintenance of intestinal homeostasis by regulating Th17 cells via production of IL-1Ra. © 2016 Sugawara et al.

  8. Reclaiming Society Publishing

    Directory of Open Access Journals (Sweden)

    Philip E. Steinberg


    Full Text Available Learned societies have become aligned with commercial publishers, who have increasingly taken over the latter’s function as independent providers of scholarly information. Using the example of geographical societies, the advantages and disadvantages of this trend are examined. It is argued that in an era of digital publication, learned societies can offer leadership with a new model of open access that can guarantee high quality scholarly material whose publication costs are supported by society membership dues.

  9. Proliferation of gynaecological scientific societies and their financial transparency: an Italian survey. (United States)

    Vercellini, Paolo; Viganò, Paola; Frattaruolo, Maria Pina; Somigliana, Edgardo


    To determine the number of Italian obstetrical and gynaecological societies, and to ascertain their financial transparency. Internet-based national survey and website content analysis. Currently active, not privately owned, non-religious, apolitical, obstetrical and gynaecological associations. From October 2014 to June 2015, scientific societies were identified using combinations of search terms, and examining the website of the two main Italian obstetrical and gynaecological organisations. Individual societies' websites were scrutinised by two independent investigators. Number of Italian obstetrical and gynaecological associations and its variation over time; 12 information categories defining the general characteristics of the societies and their websites, and the financial transparency of the associations. The initial web search yielded 56 professional obstetrical and gynaecological associations but nine were excluded for various reasons. Of the remaining 47 professional associations, 17 covered both obstetrics and gynaecology, four were specialised in obstetrics, 26 in gynaecology and 46 provided continuing medical education (CME) activities. The number of societies has quadrupled in the last 35 years, increasing at a mean rate of one additional society per year. The headquarters of the associations were located in the offices of a professional congress organiser in 15 instances, and advertisements or links to industry products were present in 12 societies' websites. Bylaws were accessible in 32 websites. No information was publicly available regarding competing interests, financial statements and quantitative external funding. The number of obstetrical and gynaecological societies is remarkably high in Italy, particularly in the gynaecological area. Despite CME activity provision, transparency of societies regarding financial issues and competing interests was almost non-existent. Policies addressing the interactions between medical associations and industry

  10. African Journal of Drug & Alcohol Studies, 16(1), 2017 Copyright ...

    African Journals Online (AJOL)

    African Journal of Drug & Alcohol Studies, 16(1), 2017. Copyright © 2017 ... Linear regression showed that males are more likely to abuse alcohol than females. (β= -.17; t = -3.47; ..... gerians through depression, suicide, road traffic accidents ...

  11. Super plastic forming of the Cd-17.4 Zn alloy; Conformado superplastico de la aleacion Cd-17.4 Zn

    Energy Technology Data Exchange (ETDEWEB)

    Llanes Briceno, J. A.; Torres Villasenor, G. [Instituto de Investigaciones en Materiales, UNAM, Mexico, D.F. (Mexico)


    In the present work the necessary steps to carry on the superplastic forming of the Cd-17.4 Zn alloy are defined. The use of either atmospheric pressure or gas pressure as forming tools is analyzed. The optimum values of the variables involved (temperature, maximum strain and sensitivity index) are determined while a method for the characterization of future superplastic alloys is set forth. The experimental characterization of the superplastic forming is achieved with free bulging of circular membranes of 12, 16, 24, 32 and 40 mm in diameter and with three different membrane thicknesses (0.4, 0.6 and 0.8 mm). [Spanish] Se definen los pasos necesarios para el conformado superplastico de la aleacion Cd-17.4Zn. Se comparan la presion atmosferica y el gas a presion como herramientas de conformado. Se determinan los valores optimos de las variables involucradas (temperatura, deformacion maxima e indice de sensibilidad) y se plantea una metodologia para la caracterizacion de futuras aleaciones superplasticas. El conformado superplastico se caracteriza experimentalmente mediante el inflado libre de membranas circulares de 12, 16, 24, 32 y 40 mm de diametro y tres diferentes espesores (0.4, 0.6 y 0.8 mm).

  12. Indian Vacuum Society: The Indian Vacuum Society (United States)

    Saha, T. K.


    The Indian Vacuum Society (IVS) was established in 1970. It has over 800 members including many from Industry and R & D Institutions spread throughout India. The society has an active chapter at Kolkata. The society was formed with the main aim to promote, encourage and develop the growth of Vacuum Science, Techniques and Applications in India. In order to achieve this aim it has conducted a number of short term courses at graduate and technician levels on vacuum science and technology on topics ranging from low vacuum to ultrahigh vacuum So far it has conducted 39 such courses at different parts of the country and imparted training to more than 1200 persons in the field. Some of these courses were in-plant training courses conducted on the premises of the establishment and designed to take care of the special needs of the establishment. IVS also regularly conducts national and international seminars and symposia on vacuum science and technology with special emphasis on some theme related to applications of vacuum. A large number of delegates from all over India take part in the deliberations of such seminars and symposia and present their work. IVS also arranges technical visits to different industries and research institutes. The society also helped in the UNESCO sponsored post-graduate level courses in vacuum science, technology and applications conducted by Mumbai University. The society has also designed a certificate and diploma course for graduate level students studying vacuum science and technology and has submitted a syllabus to the academic council of the University of Mumbai for their approval, we hope that some colleges affiliated to the university will start this course from the coming academic year. IVS extended its support in standardizing many of the vacuum instruments and played a vital role in helping to set up a Regional Testing Centre along with BARC. As part of the development of vacuum education, the society arranges the participation of

  13. 17 CFR 229.601 - (Item 601) Exhibits. (United States)


    ... accountant regarding non-reliance on a previously issued audit report or completed interim review X (8) Opinion re tax matters X X X X X X X (9) Voting trust agreement X X X X X X X (10) Material contracts X X... X X X X X X (16) Letter re change in certifying accountant 4 X X X X X X (17) Correspondence on...

  14. DGK-θ: Structure, Enzymology, and Physiological Roles

    Directory of Open Access Journals (Sweden)

    Daniel M Raben


    Full Text Available Diacylglycerol kinases (DGKs are a family of enzymes that catalyze the ATP-dependent phosphorylation of diacylglycerol (DAG to phosphatidic acid (PtdOH. The recognition of the importance of these enzymes has been increasing ever since it was determined that they played a role in the phosphatidylinositol (PtdIns cycle and a number of excellent reviews have already been written (see (1-7 among others. We now know there are ten mammalian DGKs that are organized into five classes. DGK-θ is the lone member of the Type V class of DGKs and remains as one of the least studied. This review focuses on our current understanding of the structure, enzymology, regulation, and physiological roles of this DGK and suggests some future areas of research to understand this DGK isoform.

  15. Structural Basis for Substrate Recognition by the Ankyrin Repeat Domain of Human DHHC17 Palmitoyltransferase

    Energy Technology Data Exchange (ETDEWEB)

    Verardi, Raffaello; Kim, Jin-Sik; Ghirlando, Rodolfo; Banerjee, Anirban


    DHHC enzymes catalyze palmitoylation, a major post-translational modification that regulates a number of key cellular processes. There are up to 24 DHHCs in mammals and hundreds of substrate proteins that get palmitoylated. However, how DHHC enzymes engage with their substrates is still poorly understood. There is currently no structural information about the interaction between any DHHC enzyme and protein substrates. In this study we have investigated the structural and thermodynamic bases of interaction between the ankyrin repeat domain of human DHHC17 (ANK17) and Snap25b. We solved a high-resolution crystal structure of the complex between ANK17 and a peptide fragment of Snap25b. Through structure-guided mutagenesis, we discovered key residues in DHHC17 that are critically important for interaction with Snap25b. We further extended our finding by showing that the same residues are also crucial for the interaction of DHHC17 with Huntingtin, one of its most physiologically relevant substrates.

  16. NASA Rat Acoustic Tolerance Test 1994-1995: 8 kHz, 16 kHz, 32 kHz Experiments (United States)

    Mele, Gary D.; Holley, Daniel C.; Naidu, Sujata


    Adult male Sprague-Dawley rats were exposed to chronic applied sound (74 to 79 dB, SPL) with octave band center frequencies of either 8, 16 or 32 kHz for up to 60 days. Control cages had ambient sound levels of about 62 dB (SPL). Groups of rats (test vs. control; N=9 per group) were euthanized after 0. 5. 14, 30, and 60 days. On each euthanasia day, objective evaluation of their physiology and behavior was performed using a Stress Assessment Battery (SAB) of measures. In addition, rat hearing was assessed using the brain stem auditory evoked potential (BAER) method after 60 days of exposure. No statistically significant differences in mean daily food use could be attributed to the presence of the applied test sound. Test rats used 5% more water than control rats. In the 8 kHz and 32 kHz tests this amount was statistically significant(P less than .05). This is a minor difference of questionable physiological significance. However, it may be an indication of a small reaction to the constant applied sound. Across all test frequencies, day 5 test rats had 6% larger spleens than control rats. No other body or organ weight differences were found to be statistically significant with respect to the application of sound. This spleen effect may be a transient adaptive process related to adaptation to the constant applied noise. No significant test effect on differential white blood cell counts could be demonstrated. One group demonstrated a low eosinophil count (16 kHz experiment, day 14 test group). However this was highly suspect. Across all test frequencies studied, day 5 test rats had 17% fewer total leukocytes than day 5 control rats. Sound exposed test rats exhibited 44% lower plasma corticosterone concentrations than did control rats. Note that the plasma corticosterone concentration was lower in the sound exposed test animals than the control animals in every instance (frequency exposure and number of days exposed).

  17. 37 CFR 385.16 - Reproduction and distribution rights covered. (United States)


    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Reproduction and distribution..., Other Incidental Digital Phonorecord Deliveries and Limited Downloads § 385.16 Reproduction and distribution rights covered. A compulsory license under 17 U.S.C. 115 extends to all reproduction and...

  18. Increased expression of Th17 cytokines in patients with psoriasis

    African Journals Online (AJOL)



    Feb 16, 2012 ... immune, heredity, psychology and environment factors ... ground with mortar and pestle, cooled by liquid nitrogen of the ground tissue .... Figure 1. Correction between expression of IL-17A mRNA and IL-23P19 mRNA. skin.

  19. Mathematical physiology

    CERN Document Server

    Sneyd, James


    There has been a long history of interaction between mathematics and physiology. This book looks in detail at a wide selection of mathematical models in physiology, showing how physiological problems can be formulated and studied mathematically, and how such models give rise to interesting and challenging mathematical questions. With its coverage of many recent models it gives an overview of the field, while many older models are also discussed, to put the modern work in context. In this second edition the coverage of basic principles has been expanded to include such topics as stochastic differential equations, Markov models and Gibbs free energy, and the selection of models has also been expanded to include some of the basic models of fluid transport, respiration/perfusion, blood diseases, molecular motors, smooth muscle, neuroendrocine cells, the baroreceptor loop, turboglomerular oscillations, blood clotting and the retina. Owing to this extensive coverage, the second edition is published in two volumes. ...

  20. Anatomy and physiology of phrenic afferent neurons. (United States)

    Nair, Jayakrishnan; Streeter, Kristi A; Turner, Sara M F; Sunshine, Michael D; Bolser, Donald C; Fox, Emily J; Davenport, Paul W; Fuller, David D


    Large-diameter myelinated phrenic afferents discharge in phase with diaphragm contraction, and smaller diameter fibers discharge across the respiratory cycle. In this article, we review the phrenic afferent literature and highlight areas in need of further study. We conclude that 1 ) activation of both myelinated and nonmyelinated phrenic sensory afferents can influence respiratory motor output on a breath-by-breath basis; 2 ) the relative impact of phrenic afferents substantially increases with diaphragm work and fatigue; 3 ) activation of phrenic afferents has a powerful impact on sympathetic motor outflow, and 4 ) phrenic afferents contribute to diaphragm somatosensation and the conscious perception of breathing. Much remains to be learned regarding the spinal and supraspinal distribution and synaptic contacts of myelinated and nonmyelinated phrenic afferents. Similarly, very little is known regarding the potential role of phrenic afferent neurons in triggering or modulating expression of respiratory neuroplasticity. Copyright © 2017 the American Physiological Society.

  1. Predation risk affects reproductive physiology and demography of elk. (United States)

    Creel, Scott; Christianson, David; Liley, Stewart; Winnie, John A


    Elk (Cervus elaphus) in the Greater Yellowstone Ecosystem alter patterns of aggregation, habitat selection, vigilance, and foraging in the presence of wolves (Canis lupus). Antipredator behaviors like these can reduce predation risk but are also likely to carry costs. Data from five elk populations studied for 16 site years showed that progesterone concentrations (from 1489 fecal samples) declined with the ratio of elk to wolves. In turn, progesterone concentrations were a good predictor of calf recruitment in the subsequent year. Together, these data suggest that wolves indirectly affect the reproductive physiology and the demography of elk through the costs of antipredator behavior.

  2. 33 CFR 174.17 - Contents of application for certificate of number. (United States)


    ... carrying, commercial fishing, or other commercial use. (9) Make of vessel. (10) Year vessel was..., sail or other. (16) Whether the fuel is gasoline, diesel, or other. (17) The signature of the owner. (b...

  3. Metaphors of mind and society. The origins of German psychiatry in the revolutionary era. (United States)

    Hansen, L


    Johann Christian Reil's long polemic, Rhapsodieen über die Anwendung der psychischen Curmethode der Geisteszerrütungen (1803), is a call for the reform of the treatment of the insane. It also marks a transition from the Kantian approach to physiology of his earlier work to the Naturphilosophie that increasingly characterized his publications after this time. In this essay I first survey the historiographical debates of recent years concerning society and the emergence of psychiatry. I then examine the social-cultural context of the late Aufklärung in Prussia, out of which Reil's work emerged, before sketching the intellectual background of the Rhapsodieen, which lies in the development of German physiology since the 1750s. The heart of my work is a close analysis of Reil's theory of mental illness. Here I tease out his political and cultural imagery and note the ways in which his originally Enlightenment assumptions shifted toward the Romantic amid the anxieties of the revolutionary era.

  4. Quasi-free knockout reactions with the proton-dripline nucleus {sup 17}Ne

    Energy Technology Data Exchange (ETDEWEB)

    Wamers, Felix; Aumann, Thomas [Institut fuer Kernphysik, TU, Darmstadt (Germany); Heil, Michael [Kernreaktionen und Nukleare Astrophysik, GSI, Darmstadt (Germany); Marganiec, Justyna [ExtreMe Matter Institute EMMI, GSI, Darmstadt (Germany); Plag, Ralf [Kernreaktionen und Nukleare Astrophysik, GSI, Darmstadt (Germany); Goethe Universitaet, Frankfurt a.M. (Germany); Collaboration: R3B-Collaboration


    {sup 17}Ne is a proton-dripline nucleus that has raised special interest in nuclear-structure physics in recent years. As a ({sup 15}O+2p) Borromean 3-body system, it is often considered to be a 2-proton-halo nucleus, yet lacking concluding experimental evidence about its structure. We have studied breakup reactions of 500 AMeV {sup 17}Ne secondary beams using the R{sup 3}B-LAND setup at GSI. One focus was on the quasi-free one-proton knockout in a proton-rich paraffin (CH{sub 2}) target in inverse kinematics, i.e., {sup 17}Ne(p,2p){sup 16}F{yields}{sup 15}O+p, in comparison to the one-proton knockout with a carbon target. Recoil protons have been detected with Si-Strip detectors and the surrounding 4{pi} NaI spectrometer ''Crystal Ball'', thus providing a clean signature for quasi-free knockout. First results on two-proton removal cross sections with CH{sub 2} and C targets will be presented, as well as transverse momentum distributions of the {sup 15}O core in {sup 17}Ne. Projectile-like forward protons after one-proton knockout from {sup 17}Ne have been measured in coincidence with the {sup 15}O residual core, leading to the relative-energy spectrum of the unbound {sup 16}F. Possible interpretations and implications regarding the structure of {sup 17}Ne are discussed.

  5. 51. Annual symposium of the Austrian Physical Society

    International Nuclear Information System (INIS)

    Oberhummer, H.


    The 51th Symposium of the Austrian Physical Society was held from 17-21 September 2001 at the Technical University of Vienna (Austria). The topics covered deal with: energy (greenhouse effect, climatic change, environment protection, energy system transformation, innovative energy technologies), neutrons and synchrotron radiation, quantum mechanics, microscopy, accelerator-driven systems, physics aspects of radiotherapy, nano world, micro cosmos, modern physics, life in the universe, x-ray fluorescence, heavy-ion accelerator mass spectrometry, acoustics, atomic-, molecular- and plasma physics, solid-state physics, nuclear and particle physics, medical-, bio-and environmental physics, quantum electronics, electrodynamics and optics. Those contributions which are in the INIS subject scope are indexed separately. (nevyjel)

  6. Uncertainty and variability in computational and mathematical models of cardiac physiology. (United States)

    Mirams, Gary R; Pathmanathan, Pras; Gray, Richard A; Challenor, Peter; Clayton, Richard H


    predictive model outputs. We propose that the future of the Cardiac Physiome should include a probabilistic approach to quantify the relationship of variability and uncertainty of model inputs and outputs. © 2016 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.

  7. War, space, and the evolution of Old World complex societies. (United States)

    Turchin, Peter; Currie, Thomas E; Turner, Edward A L; Gavrilets, Sergey


    How did human societies evolve from small groups, integrated by face-to-face cooperation, to huge anonymous societies of today, typically organized as states? Why is there so much variation in the ability of different human populations to construct viable states? Existing theories are usually formulated as verbal models and, as a result, do not yield sharply defined, quantitative predictions that could be unambiguously tested with data. Here we develop a cultural evolutionary model that predicts where and when the largest-scale complex societies arose in human history. The central premise of the model, which we test, is that costly institutions that enabled large human groups to function without splitting up evolved as a result of intense competition between societies-primarily warfare. Warfare intensity, in turn, depended on the spread of historically attested military technologies (e.g., chariots and cavalry) and on geographic factors (e.g., rugged landscape). The model was simulated within a realistic landscape of the Afroeurasian landmass and its predictions were tested against a large dataset documenting the spatiotemporal distribution of historical large-scale societies in Afroeurasia between 1,500 BCE and 1,500 CE. The model-predicted pattern of spread of large-scale societies was very similar to the observed one. Overall, the model explained 65% of variance in the data. An alternative model, omitting the effect of diffusing military technologies, explained only 16% of variance. Our results support theories that emphasize the role of institutions in state-building and suggest a possible explanation why a long history of statehood is positively correlated with political stability, institutional quality, and income per capita.

  8. Smart sensors and virtual physiology human approach as a basis of personalized therapies in diabetes mellitus. (United States)

    Fernández Peruchena, Carlos M; Prado-Velasco, Manuel


    Diabetes mellitus (DM) has a growing incidence and prevalence in modern societies, pushed by the aging and change of life styles. Despite the huge resources dedicated to improve their quality of life, mortality and morbidity rates, these are still very poor. In this work, DM pathology is revised from clinical and metabolic points of view, as well as mathematical models related to DM, with the aim of justifying an evolution of DM therapies towards the correction of the physiological metabolic loops involved. We analyze the reliability of mathematical models, under the perspective of virtual physiological human (VPH) initiatives, for generating and integrating customized knowledge about patients, which is needed for that evolution. Wearable smart sensors play a key role in this frame, as they provide patient's information to the models.A telehealthcare computational architecture based on distributed smart sensors (first processing layer) and personalized physiological mathematical models integrated in Human Physiological Images (HPI) computational components (second processing layer), is presented. This technology was designed for a renal disease telehealthcare in earlier works and promotes crossroads between smart sensors and the VPH initiative. We suggest that it is able to support a truly personalized, preventive, and predictive healthcare model for the delivery of evolved DM therapies.

  9. Comparison of electromagnetic and nuclear dissociation of 17Ne (United States)

    Wamers, F.; Marganiec, J.; Aksouh, F.; Aksyutina, Yu.; Alvarez-Pol, H.; Aumann, T.; Beceiro-Novo, S.; Bertulani, C. A.; Boretzky, K.; Borge, M. J. G.; Chartier, M.; Chatillon, A.; Chulkov, L. V.; Cortina-Gil, D.; Emling, H.; Ershova, O.; Fraile, L. M.; Fynbo, H. O. U.; Galaviz, D.; Geissel, H.; Heil, M.; Hoffmann, D. H. H.; Hoffman, J.; Johansson, H. T.; Jonson, B.; Karagiannis, C.; Kiselev, O. A.; Kratz, J. V.; Kulessa, R.; Kurz, N.; Langer, C.; Lantz, M.; Le Bleis, T.; Lehr, C.; Lemmon, R.; Litvinov, Yu. A.; Mahata, K.; Müntz, C.; Nilsson, T.; Nociforo, C.; Ott, W.; Panin, V.; Paschalis, S.; Perea, A.; Plag, R.; Reifarth, R.; Richter, A.; Riisager, K.; Rodriguez-Tajes, C.; Rossi, D.; Savran, D.; Schrieder, G.; Simon, H.; Stroth, J.; Sümmerer, K.; Tengblad, O.; Typel, S.; Weick, H.; Wiescher, M.; Wimmer, C.


    The Borromean drip-line nucleus 17Ne has been suggested to possess a two-proton halo structure in its ground state. In the astrophysical r p -process, where the two-proton capture reaction 15O(2 p ,γ )17Ne plays an important role, the calculated reaction rate differs by several orders of magnitude between different theoretical approaches. To add to the understanding of the 17Ne structure we have studied nuclear and electromagnetic dissociation. A 500 MeV/u 17Ne beam was directed toward lead, carbon, and polyethylene targets. Oxygen isotopes in the final state were measured in coincidence with one or two protons. Different reaction branches in the dissociation of 17Ne were disentangled. The relative populations of s and d states in 16F were determined for light and heavy targets. The differential cross section for electromagnetic dissociation (EMD) shows a continuous internal energy spectrum in the three-body system 15O+2 p . The 17Ne EMD data were compared to current theoretical models. None of them, however, yields satisfactory agreement with the experimental data presented here. These new data may facilitate future development of adequate models for description of the fragmentation process.

  10. Effects of rare earth elements and REE-binding proteins on physiological responses in plants. (United States)

    Liu, Dongwu; Wang, Xue; Chen, Zhiwei


    Rare earth elements (REEs), which include 17 elements in the periodic table, share chemical properties related to a similar external electronic configuration. REEs enriched fertilizers have been used in China since the 1980s. REEs could enter the cell and cell organelles, influence plant growth, and mainly be bound with the biological macromolecules. REE-binding proteins have been found in some plants. In addition, the chlorophyll activities and photosynthetic rate can be regulated by REEs. REEs could promote the protective function of cell membrane and enhance the plant resistance capability to stress produced by environmental factors, and affect the plant physiological mechanism by regulating the Ca²⁺ level in the plant cells. The focus of present review is to describe how REEs and REE-binding proteins participate in the physiological responses in plants.

  11. Influence of Music on Preoperative Anxiety and Physiologic Parameters in Women Undergoing Gynecologic Surgery. (United States)

    Labrague, Leodoro J; McEnroe-Petitte, Denise M


    The aim of this study was to determine the influence of music on anxiety levels and physiologic parameters in women undergoing gynecologic surgery. This study employed a pre- and posttest experimental design with nonrandom assignment. Ninety-seven women undergoing gynecologic surgery were included in the study, where 49 were allocated to the control group (nonmusic group) and 48 were assigned to the experimental group (music group). Preoperative anxiety was measured using the State Trait Anxiety Inventory (STAI) while noninvasive instruments were used in measuring the patients' physiologic parameters (blood pressure [BP], pulse [P], and respiration [R]) at two time periods. Women allocated in the experimental group had lower STAI scores (t = 17.41, p music during the preoperative period in reducing anxiety and unpleasant symptoms in women undergoing gynecologic surgery. © The Author(s) 2014.

  12. Archaeological Remains Accounting for the Presence and Exploitation of the North Atlantic Right Whale Eubalaena glacialis on the Portuguese Coast (Peniche, West Iberia), 16th to 17th Century (United States)

    Teixeira, António; Venâncio, Rui; Brito, Cristina


    The former occurrence of the North Atlantic right whale Eubalaena glacialis on the Portuguese coast may be inferred from the historical range of that species in Europe and in NW Africa. It is generally accepted that it was the main prey of coastal whaling in the Middle Ages and in the pre-modern period, but this assumption still needs firming up based on biological and archaeological evidence. We describe the skeletal remains of right whales excavated at Peniche in 2001–2002, in association with archaeological artefacts. The whale bones were covered by sandy sediments on the old seashore and they have been tentatively dated around the 16th to 17th centuries. This study contributes material evidence to the former occurrence of E. glacialis in Portugal (West Iberia). Some whale bones show unequivocal man-made scars. These are associated to wounds from instruments with a sharp-cutting blade. This evidence for past human interaction may suggest that whaling for that species was active at Peniche around the early 17th century. PMID:24505251

  13. Archaeological remains accounting for the presence and exploitation of the North Atlantic right whale Eubalaena glacialis on the Portuguese Coast (Peniche, West Iberia, 16th to 17th Century.

    Directory of Open Access Journals (Sweden)

    António Teixeira

    Full Text Available The former occurrence of the North Atlantic right whale Eubalaena glacialis on the Portuguese coast may be inferred from the historical range of that species in Europe and in NW Africa. It is generally accepted that it was the main prey of coastal whaling in the Middle Ages and in the pre-modern period, but this assumption still needs firming up based on biological and archaeological evidence. We describe the skeletal remains of right whales excavated at Peniche in 2001-2002, in association with archaeological artefacts. The whale bones were covered by sandy sediments on the old seashore and they have been tentatively dated around the 16th to 17th centuries. This study contributes material evidence to the former occurrence of E. glacialis in Portugal (West Iberia. Some whale bones show unequivocal man-made scars. These are associated to wounds from instruments with a sharp-cutting blade. This evidence for past human interaction may suggest that whaling for that species was active at Peniche around the early 17th century.

  14. Quantitative psychology : The 81st Annual Meeting of the Psychometric Society, Asheville, North Carolina, 2016

    NARCIS (Netherlands)

    van der Ark, L.A.; Wiberg, M.; Culpepper, S.A.; Douglas, J.A.; Wang, W.-C.


    This proceedings volume compiles and expands on selected and peer reviewed presentations given at the 81st Annual Meeting of the Psychometric Society (IMPS), organized by the University of North Carolina at Greensboro, and held in Asheville, North Carolina, July 11th to 17th, 2016.IMPS is one of the

  15. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Pulmonology”

    Directory of Open Access Journals (Sweden)

    Various Authors


    Full Text Available Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015ORGANIZING INSTITUTIONSEuropean Society for Neonatology (ESN, European Society for Paediatric Research (ESPR, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNI, with the local host of Hungarian Society of Perinatology and Obstetric Anesthesiology, Hungarian Society of Perinatology (MPT, supported by Council of International Neonatal Nurses (COINN, organizing secretariat MCA Scientific EventsPROGRAMME COMMITTEEArtúr Beke (Hungarian Society, Morten Breindahl (ESN, Giuseppe Buonocore (UENPS, Pierre Gressens (ESPR, Silke Mader (EFCNI, Manuel Sánchez Luna (UENPS, Miklós Szabó (Hungarian Society of Perinatology, Luc Zimmermann (ESPR Session “Pulmonology”ABS 1. URINE NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN AS A MARKER OF BRONCHOPULMONARY DYSPLASIA AND RETINOPATHY OF PREMATURITY IN PRETERM NEONATES • H. Ergin, T. Atilgan, M. Dogan, O.M.A. Ozdemir, C. YeniseyABS 2. LUNG COMPLIANCE AND LUNG ULTRASOUND DURING POSTNATAL ADAPTATION IN HEALTHY NEWBORN INFANTS • L. Süvari, L. Martelius, C. Janér, A. Kaskinen, O. Pitkänen, T. Kirjavainen, O. Helve, S. AnderssonABS 3. PRE-DISCHARGE RESPIRATORY OUTCOMES IN SMALL-FOR-GESTATIONAL-AGE AND APPROPRIATE-FOR-GESTATIONAL-AGE VERY PRETERM INFANTS • A. Matic, A. RistivojevicABS 4. THE EFFECT OF CHANGING OXYGEN SATURATION TARGET RANGE ON COMPLIANCE IN OXYGEN SATURATION TARGETING IN THE NEONATAL INTENSIVE CARE UNIT • H.A. van Zanten, S. Pauws, E.C.H. Beks, B.J. Stenson, E. Lopriore, A.B. te PasABS 5. BINASAL PRONG VERSUS NASAL MASK FOR APPLYING CPAP TO PRETERM INFANTS: RANDOMIZED CONTROLLED TRIAL • B. Say, G. Kanmaz, S.S. OguzABS 6. TRAINING AND RAISING AWARENESS IMPROVES COMPLIANCE IN OXYGEN SATURATION TARGETING IN THE NEONATAL INTENSIVE CARE UNIT • H.A. van Zanten, S. Pauws, E.C.H. Beks, B.J. Stenson, E

  16. Broadening Participation in the Society for Integrative and Comparative Biology. (United States)

    Wilga, Cheryl A D; Nishiguchi, Michele; Tsukimura, Brian


    The goal of the Society for Integrative and Comparative Biology's Broadening Participation Committee (SICB BPC) is to increase the number of underrepresented group (URG) members within the society and to expand their capabilities as future researchers and leaders within SICB. Our short-term 10-year goal was to increase the recruitment and retention of URG members in the society by 10%. Our long-term 25-year goal is to increase the membership of URG in the society through recruitment and retention until the membership demographic mirrors that of the US Census. Our plans to accomplish this included establishment of a formal standing committee, establishment of a moderate budget to support BPC activities, hosting professional development workshops, hosting diversity and mentor socials, and obtaining grant funds to supplement our budget. This paper documents broadening participation activities in the society, discusses the effectiveness of these activities, and evaluates BPC goals after 5 years of targeted funded activities. Over the past 5 years, the number of URG members rose by 5.2% to a total of 16.2%, members who report ethnicity and gender increased by 25.2% and 18%, respectively, and the number of members attending BPC activities has increased to 33% by 2016. SICB has made significant advances in broadening participation, not only through increased expenditures, but also with a commitment by its members and leadership to increase diversity. Most members realize that increasing diversity will both improve the Society's ability to develop different approaches to tackling problems within integrative biology, and help solve larger global issues that are evident throughout science and technology fields. In addition, having URG members as part of the executive committee would provide other URG members role models within the society, as well as have a voice in the leadership that represents diversity and inclusion for all scientists. © The Author 2017. Published by

  17. Meta-analysis of digital game and study characteristics eliciting physiological stress responses. (United States)

    van der Vijgh, Benny; Beun, Robbert-Jan; Van Rood, Maarten; Werkhoven, Peter


    Digital games have been used as stressors in a range of disciplines for decades. Nonetheless, the underlying characteristics of these stressors and the study in which the stressor was applied are generally not recognized for their moderating effect on the measured physiological stress responses. We have therefore conducted a meta-analysis that analyzes the effects of characteristics of digital game stressors and study design on heart rate, systolic and diastolic blood pressure, in studies carried out from 1976 to 2012. In order to assess the differing quality between study designs, a new scale is developed and presented, coined reliability of effect size. The results show specific and consistent moderating functions of both game and study characteristics, on average accounting for around 43%, and in certain cases up to 57% of the variance found in physiological stress responses. Possible cognitive and physiological processes underlying these moderating functions are discussed, and a new model integrating these processes with the moderating functions is presented. These findings indicate that a digital game stressor does not act as a stressor by virtue of being a game, but rather derives its stressor function from its characteristics and the methodology in which it is used. This finding, together with the size of the associated moderations, indicates the need for a standardization of digital game stressors. © 2015 Society for Psychophysiological Research.

  18. In-situ effects of eutrophication and overfishing on physiology and bacterial diversity of the red sea coral Acropora hemprichii.

    KAUST Repository

    Jessen, Christian; Lizcano, Javier; Bayer, Till; Roder, Cornelia; Aranda, Manuel; Wild, Christian; Voolstra, Christian R.


    pressures on these reefs, but there is no information available about their potential effects on the associated microbial community. Therefore, we compared holobiont physiology and 16S-based bacterial communities of tissue and mucus of the hard coral

  19. Physiological response and productivity of safflower lines under water deficit and rehydration. (United States)

    Bortolheiro, Fernanda P A P; Silva, Marcelo A


    Water deficit is one of the major stresses affecting plant growth and productivity worldwide. Plants induce various morphological, physiological, biochemical and molecular changes to adapt to the changing environment. Safflower (Carthamus tinctorius L.), a potential oil producer, is highly adaptable to various environmental conditions, such as lack of rainfall and temperatures. The objective of this work was to study the physiological and production characteristics of six safflower lines in response to water deficit followed by rehydration. The experiment was conducted in a protected environment and consisted of 30 days of water deficit followed by 18 days of rehydration. A differential response in terms of photosynthetic pigments, electrolyte leakage, water potential, relative water content, grain yield, oil content, oil yield and water use efficiency was observed in the six lines under water stress. Lines IMA 04, IMA 10, IMA 14 showed physiological characteristics of drought tolerance, with IMA 14 and IMA 16 being the most productive after water deficit. IMA 02 and IMA 21 lines displayed intermediate characteristics of drought tolerance. It was concluded that the lines responded differently to water deficit stress, showing considerable genetic variation and influence to the environment.

  20. Physiological response and productivity of safflower lines under water deficit and rehydration

    Directory of Open Access Journals (Sweden)



    Full Text Available ABSTRACT Water deficit is one of the major stresses affecting plant growth and productivity worldwide. Plants induce various morphological, physiological, biochemical and molecular changes to adapt to the changing environment. Safflower (Carthamus tinctorius L., a potential oil producer, is highly adaptable to various environmental conditions, such as lack of rainfall and temperatures. The objective of this work was to study the physiological and production characteristics of six safflower lines in response to water deficit followed by rehydration. The experiment was conducted in a protected environment and consisted of 30 days of water deficit followed by 18 days of rehydration. A differential response in terms of photosynthetic pigments, electrolyte leakage, water potential, relative water content, grain yield, oil content, oil yield and water use efficiency was observed in the six lines under water stress. Lines IMA 04, IMA 10, IMA 14 showed physiological characteristics of drought tolerance, with IMA 14 and IMA 16 being the most productive after water deficit. IMA 02 and IMA 21 lines displayed intermediate characteristics of drought tolerance. It was concluded that the lines responded differently to water deficit stress, showing considerable genetic variation and influence to the environment.