Performances of the Alpha-X RF gun on the PHIL accelerator at LAL

Science.gov (United States)

Vinatier, T.; Bruni, C.; Roux, R.; Brossard, J.; Chancé, S.; Cayla, J. N.; Chaumat, V.; Xu, G.; Monard, H.

2015-10-01

The Alpha-X RF-gun was designed to produce an ultra-short (laser-driven plasma accelerator with a short wavelength accelerating medium. It has been demonstrated on PHIL (Photo-Injector at LAL) that the coaxial RF coupling, chosen to preserve the gun field cylindrical symmetry, is perfectly understood and allows reaching the required peak accelerating field of 100 MV/m giving beam energy of 6.3 MeV. Moreover, a quite low beam rms relative energy spread of 0.15% at 3.8 MeV has been measured, completely agreeing with simulations. Dark current, quantum efficiencies and dephasing curves measurements have also been performed. They all show high values of the field enhancement factor β, which can be explained by the preparation of the photocathodes. Finally, measurements on the transverse phase-space have been carried out, with some limitations given by the difficult modelization of one of the PHIL solenoid magnets and by the enlargement of the beam transverse dimensions due to the use of YAG screens. These measurements give a normalized rms transverse emittance around 5π mm mrad, which does not fulfill the requirement for the Alpha-X project.

Adolescent Girls' Self-Concept and Its Related Factors Based on Roy Adaptation Model

OpenAIRE

M. Basiri Moghadam; SH. Khosravan; L. Sadeghmoghadam; N. Ebrahimi Senoo

2017-01-01

Aims: One of the most important factors of individual health in the adolescents is the self-concept. As a nursing model, the Roy adaptation model mainly investigates the factor. The aim of the study was to investigate the self-concept and its related factors in the adolescent girls in Gonabad Township, based on the Roy adaptation model. Instrument & Methods: In the descriptive cross-sectional study, 270 adolescent girls were studied in Gonabad Township, Iran, in 2015. The subjects were s...

An Interview with Professor Roy Caldwell

OpenAIRE

Chowdhary, Kuntal; Bhat, Prashant; Rosen, Jared; Naughton, Ida; Wang, Jingyan

2013-01-01

Envision the underwater world: vibrant coral, swaying seaweed, and lively creatures abound. However, the postcards and National Geographic covers that try to capture the beauty of this picturesque habitat can only represent it at one moment in time -- in reality, the landscape is hardly static, since many of its animals are capable of body modifications to change their shape and color. To understand the coloration and color vision of sea creatures, UC Berkeley Professor Roy L. Caldwell resear...

Resisting the author: JT LeRoy's fictional authorship

NARCIS (Netherlands)

Loontjens, J.

2008-01-01

In the last decade, the interest in the relation between author and text, author and autobiography, seems to have grown. In my article, I use the story of the author JT LeRoy as a framework to analyse what this growing interest means for our understanding of the word "author." JT LeRoy’s work was

Roy-Steiner equations for πN scattering

Science.gov (United States)

de Elvira, J. Ruiz; Ditsche, C.; Hoferichter, M.; Kubis, B.; Meißner, U.-G.

2015-10-01

In this talk, we briefly review our ongoing collaboration to precisely determine the low-energy πN scattering amplitude by means of Roy-Steiner equations. After giving a brief overview of this system of dispersive equations and their application to πN scattering, we proceed to solve for the lower partial waves of the s-channel (πN → πN) and the t-channel l( {π π to bar NN} right) sub-problems.

Antioxidant activity of a new aromatic geranyl derivative of the resinous exudates from Heliotropium glutinosum Phil.

Science.gov (United States)

Modak, Brenda; Rojas, Macarena; Torres, René; Rodilla, Jesús; Luebert, Federico

2007-05-21

Heliotropium glutinosum Phil. (Heliotropiceae) is a resinous bush that grows at a height of 2000 m in Chañaral, Chile. From the resinous exudates of Heliotropium glutinosum Phil. a new aromatic geranyl derivative: 4-methoxy-3-[(2)-7'-methyl-3'-hydroxymethyl-2',6'-octadienyl] phenol (1) and three flavonoids: 5,3'-dihydroxy-7,4'-dimethoxyflavanone (2), 5,4'-dihydroxy-7-methoxyflavanone (3) and 4'-acetyl-5-hydroxy-7-methoxyflavanone (4) were isolated and their structures were determined. Their antioxidant activity were evaluated using the bleaching of ABTS and DPPH derived cation radical methods and expressed in terms of FRE (fast reacting equivalents) and TRE (total reacting equivalents), where FRE is a good measure of the quick protection of a given compound against oxidants and TRE measures the degree of long-term protection of the antioxidant, or how effective it is against a strong oxidative stress.

Historical evolution of the concept environment proposed in the Roy adaptation model Evolución histórica del concepto entorno propuesto en el modelo de la adaptación de Roy Evolução histórica do conceito ambiente proposto no modelo da adaptação de Roy

Directory of Open Access Journals (Sweden)

Marcos Venícios de Oliveira Lopes

2006-04-01

Full Text Available The concern for the development of concepts becomes even more important when we report to its use in Nursing theories, in which some concepts are considered central, such as person, environment, health and nursing. This study aims to discuss the historical evolution of the environment concept used in the Roy Adaptation Model. The method of analysis the study was based on is the evolutionary conceptual analysis of the concept Environment of the Roy Adaptation Model. According to the research results, Environment is introduced as the second major concept in the Roy Adaptation Model. In this theorist's interpretation of the environment, we notice her interest in surpassing the mechanistic point of view upon which the first version of the model was based. The approach of the concept of interaction between people and groups seems to represent an improvement, influenced by the current thoughts that are preeminent in nursing.La preocupación con el desarrollo de conceptos se vuelve más importante cuando nos reportamos para su uso en teorías de Enfermería. En ellas, algunos conceptos son considerados centrales, tales como persona, ambiente, salud y enfermería. Este artículo visa examinar la evolución histórica del concepto de ambiente utilizado en el Modelo de Adaptación de Roy. El método de análisis en que el estudio fue basado es el análisis conceptual evolucionario del concepto Ambiente del Modelo de Adaptación de Roy. De acuerdo con los resultados del estudio, Ambiente es introducido como el segundo concepto más importante en el Modelo de Adaptación de Roy. En la interpretación que la teórica hace del ambiente, notamos su interés en ultrapasar el punto de vista mecanicista en que la primera versión del modelo era basada. La propuesta de interacción del concepto ambiente con personas y grupos parece representar una mejoría, influenciada por los pensamientos corrientes que son predominantes en la enfermería.A preocupação com o

The Roy Adaptation Model and Content Analysis

OpenAIRE

Jacqueline Fawcett

2006-01-01

El objetivo del presente estudio consiste en explicar de qué manera se puede utilizar el Modelo de Adaptación de Roy para guiar el análisis de contenido cuantitativo y cualitativo de respuestas a preguntas abiertas en una entrevista. Estas respuestas pueden ser catalogadas como adaptativas o inefectivas respecto de los modos de adaptación psicosocial, autoconcepto, función de rol e interdependencia y, entonces, asociadas a un determinado puntaje de adaptación.

The Roy Adaptation Model and Content Analysis

OpenAIRE

Fawcett, Jacqueline

2006-01-01

The purpose of this paper is to explain how the Roy Adaptation Model can be used to guide a combined qualitative and quantitative content analysis of responses to open-ended interviews questions. Responses can be categorized as adaptive or ineffective within the physiological, self-concept, role function, and interdependence modes of adaptation and then tallied to yield an adaptation score. El objetivo del presente estudio consiste en explicar de qué manera se puede utilizar el Modelo de A...

Da pesquisa à prática de enfermagem aplicando o modelo de adaptação de Roy De la investigación a la práctica de enfermería mediante la aplicación del modelo de adaptación de Roy From research to nursing practice applying the Roy adaptation model

Directory of Open Access Journals (Sweden)

Sónia Margarida Santos Coelho

2011-12-01

Full Text Available Os modelos e as teorias de enfermagem contribuem para o desenvolvimento do conhecimento em enfermagem, guiando as investigações no sentido do desenvolvimento da disciplina e, consequentemente, da prática. De acordo como o Modelo de Adaptação de Roy, a pessoa é vista como um ser adaptável com mecanismos que permitem a adaptação de comportamentos em resposta aos estímulos ambientais. De fato, a pessoa é o enfoque central dos cuidados de enfermagem, visando-se sempre a melhoria dos cuidados prestados baseados em investigação. A metodologia do Modelo de Adaptação de Roy baseia-se na aplicabilidade do processo de enfermagem, facilitando aos enfermeiros a coleta de dados, estabelecimento de objetivos e diagnósticos de enfermagem, a determinação de intervenções de enfermagem e a posterior avaliação do processo. Assim o objetivo desta pesquisa é realizar uma revisão crítica da aplicação do Modelo Adaptação de Roy aplicado à prática e à pesquisa em Enfermagem.Los modelos y teorías de enfermería contribuyen para el desarrollo del conocimiento en Enfermería, guiando las investigaciones para el desarrollo de la disciplina y, consecuentemente, de la práctica. De acuerdo con el Modelo de Adaptación de Roy se ve la persona como un mecanismo de adaptación que permite el ajuste del comportamiento en respuesta a estímulos ambientales. De hecho, la persona es el foco central de la atención de enfermería, buscando siempre el mejoramiento de la atención basada en la investigación. La metodología del Modelo de Adaptación de Roy se basa en la aplicación del proceso de enfermería, lo que facilita a las enfermeras para recopilar datos, establecer metas y diagnósticos de enfermería, la determinación de las intervenciones de enfermería y el proceso de evaluación posterior. Así, el objetivo de esta investigación es una revisión crítica de la aplicación del Modelo de Adaptación de Roy empleado para la práctica y la

Antioxidant Activity of a New Aromatic Geranyl Derivative of the Resinous Exudates from Heliotropium glutinosum Phil.

Directory of Open Access Journals (Sweden)

Federico Luebert

2007-05-01

Full Text Available Heliotropium glutinosum Phil. (Heliotropiceae is a resinous bush that grows at a height of 2000 m in Chañaral, Chile. From the resinous exudates of Heliotropium glutinosum Phil. a new aromatic geranyl derivative: 4-methoxy-3-[(2-7’-methyl-3’-hydroxymethyl-2’,6’-octadienyl] phenol (1 and three flavonoids: 5,3'-dihydroxy-7,4'-dimethoxyflavanone (2, 5,4'-dihydroxy-7-methoxyflavanone (3 and 4'-acetyl-5-hydroxy-7-methoxyflavanone (4 were isolated and their structures were determined. Their antioxidant activity were evaluated using the bleaching of ABTS and DPPH derived cation radical methods and expressed in terms of FRE (fast reacting equivalents and TRE (total reacting equivalents, where FRE is a good measure of the quick protection of a given compound against oxidants and TRE measures the degree of long-term protection of the antioxidant, or how effective it is against a strong oxidative stress.

Effect of Treatment Education Based on the Roy Adaptation Model on Adjustment of Hemodialysis Patients.

Science.gov (United States)

Kacaroglu Vicdan, Ayse; Gulseven Karabacak, Bilgi

2016-01-01

The Roy Adaptation Model examines the individual in 4 fields: physiological mode, self-concept mode, role function mode, and interdependence mode. Hemodialysis treatment is associated with the Roy Adaptation Model as it involves fields that might be needed by the individual with chronic renal disease. This research was conducted as randomized controlled experiment with the aim of determining the effect of the education given in accordance with the Roy Adaptation Model on physiological, psychological, and social adaptation of individuals undergoing hemodialysis treatment. This was a random controlled experimental study. The study was conducted at a dialysis center in Konya-Aksehir in Turkey between July 1 and December 31, 2012. The sample was composed of 82 individuals-41 experimental and 41 control. In the second interview, there was a decrease in the systolic blood pressures and body weights of the experimental group, an increase in the scores of functional performance and self-respect, and a decrease in the scores of psychosocial adaptation. In the control group, on the other hand, there was a decrease in the scores of self-respect and an increase in the scores of psychosocial adaptation. The 2 groups were compared in terms of adaptation variables and a difference was determined on behalf of the experimental group. The training that was provided and evaluated for individuals receiving hemodialysis according to 4 modes of the Roy Adaptation Model increased physical, psychological, and social adaptation.

Roy's Adaptation Model-Guided Education and Promoting the Adaptation of Veterans With Lower Extremities Amputation.

Science.gov (United States)

Azarmi, Somayeh; Farsi, Zahra

2015-10-01

Any defect in extremities of the body can affect different life aspects. The purpose of this study was to investigate the effect of Roy's adaptation model-guided education on promoting the adaptation of veterans with lower extremities amputation. In a randomized clinical trial, 60 veterans with lower extremities amputation referring to Kowsar Orthotics and Prosthetics Center of veterans clinic in Tehran, Iran, were recruited with convenience method and were randomly assigned to intervention and control groups during 2013 - 2014. For data collection, Roy's adaptation model questionnaire was used. After completing the questionnaires in both groups, maladaptive behaviors were determined in the intervention group and an education program based on Roy's adaptation model was implemented. After two months, both groups completed the questionnaires again. Data was analyzed with SPSS software. Independent t-test showed statistically significant differences between the two groups in the post-test stage in terms of the total score of adaptation (P = 0.001) as well as physiologic (P = 0.0001) and role function modes (P = 0.004). The total score of adaptation (139.43 ± 5.45 to 127.54 ± 14.55, P = 0.006) as well as the scores of physiologic (60.26 ± 5.45 to 53.73 ± 7.79, P = 0.001) and role function (20.30 ± 2.42 to 18.13 ± 3.18, P = 0.01) modes in the intervention group significantly increased, whereas the scores of self-concept (42.10 ± 4.71 to 39.40 ± 5.67, P = 0.21) and interdependence (16.76 ± 2.22 to 16.30 ± 2.57, P = 0.44) modes in the two stages did not have a significant difference. Findings of this research indicated that the Roy's adaptation model-guided education promoted the adaptation level of physiologic and role function modes in veterans with lower extremities amputation. However, this intervention could not promote adaptation in self-concept and interdependence modes. More intervention is advised based on Roy's adaptation model for improving the

Adaptación psicosocial de los adolescentes pos-trasplante renal, según la teoría de Roy Adaptação psicossocial do adolescente pós-trasplante renal segundo a teoria de Roy Psicosocial adaptation of post-renal transplanted adolescents according to Roy Theory

Directory of Open Access Journals (Sweden)

Ana Luisa Brandão de Carvalho Lirax

2005-03-01

Full Text Available El objetivo de este trabajo fue conocer las repercusiones psicosociales del adolescente después del trasplante renal y los mecanismos de adaptación utilizados en su nueva condición de vida. Es un estudio cualitativo, mediante entrevistas estructuradas. Fueron entrevistados diecinueve adolescentes que estaban en acompañamiento en dos hospitales públicos de Ceará-Brasil, después de la aprobación del proyecto por parte del Comité de Ética de las Instituciones y obtención del consentimiento libre e informado. Los resultados fueron analizados conforme a la teoría de la adaptación de Roy. Se identificaron problemas de adaptación, como: limitación física, vergüenza, miedo al rechazo e impotencia. Sin embargo, esos adolescentes pudieron superar tal situación y mejorar la adaptación a su nueva condición. Concluimos que la teoría de Roy permitió un análisis más profundo de los adolescentes, permitiéndoles un tratamiento más eficaz y, consecuentemente, una mejor calidad de vida.É um estudo descritivo, com análise qualitativo. O objetivo deste trabalho foi conhecer as repercussões psicossociais do adolescente após o trasplante renal e os mecanismos adaptativos utilizados por estes na sua nova condição de vida. Foram entrevistados dezenove adolescentes que estavam em acompanhamento ambulatorial em dois hospitais públicos do Ceará-Brasil, após aprovação do projeto pelo Comitê de Ética das Instituições e obtenção do consentimento livre e esclarecido. Os resultados foram analisados conforme a teoria da adaptação de Roy. Foram identificados problemas de adaptação, como: limitação física, vergonha, medo de rejeição e impotência. Contudo, esses adolescentes puderam superar tal situação e melhorar a adaptação à sua nova condição. Concluímos que a teoria de Roy permitiu uma análise mais aprofundada desses adolescentes, permitindo lhes um tratamento mais eficaz e, conseqüentemente, uma melhor qualidade de

Performances of the Alpha-X RF gun on the PHIL accelerator at LAL

Energy Technology Data Exchange (ETDEWEB)

Vinatier, T., E-mail: vinatier@lal.in2p3.fr [Laboratoire de l' Accélérateur Linéaire (LAL), Université Paris Sud, UMR 8607, bâtiment 200, 91898 Orsay Cedex (France); Bruni, C. [Laboratoire de l' Accélérateur Linéaire (LAL), Université Paris Sud, UMR 8607, bâtiment 200, 91898 Orsay Cedex (France); Roux, R. [Laboratoire de l' Accélérateur Linéaire (LAL), Université Paris Sud, UMR 8607, bâtiment 200, 91898 Orsay Cedex (France); Laboratoire d' Etude des Eléments Légers, CEA IRAMIS, bâtiment 524, 91191 Gif sur Yvette Cedex (France); Brossard, J. [Laboratoire de l' Accélérateur Linéaire (LAL), Université Paris Sud, UMR 8607, bâtiment 200, 91898 Orsay Cedex (France); Laboratoire Astroparticule et Cosmologie, Université Paris 7, UMR 7164, bâtiment Condorcet, 75205 Paris Cedex (France); Chancé, S.; Cayla, J.N.; Chaumat, V. [Laboratoire de l' Accélérateur Linéaire (LAL), Université Paris Sud, UMR 8607, bâtiment 200, 91898 Orsay Cedex (France); and others

2015-10-11

The Alpha-X RF-gun was designed to produce an ultra-short (<100 fs rms), 100 pC and 6.3 MeV electron beam with a normalized rms transverse emittance of 1π mm mrad for a gun peak accelerating field of 100 MV/m. Such beams will be required by the Alpha-X project, which aims to study a laser-driven plasma accelerator with a short wavelength accelerating medium. It has been demonstrated on PHIL (Photo-Injector at LAL) that the coaxial RF coupling, chosen to preserve the gun field cylindrical symmetry, is perfectly understood and allows reaching the required peak accelerating field of 100 MV/m giving beam energy of 6.3 MeV. Moreover, a quite low beam rms relative energy spread of 0.15% at 3.8 MeV has been measured, completely agreeing with simulations. Dark current, quantum efficiencies and dephasing curves measurements have also been performed. They all show high values of the field enhancement factor β, which can be explained by the preparation of the photocathodes. Finally, measurements on the transverse phase-space have been carried out, with some limitations given by the difficult modelization of one of the PHIL solenoid magnets and by the enlargement of the beam transverse dimensions due to the use of YAG screens. These measurements give a normalized rms transverse emittance around 5π mm mrad, which does not fulfill the requirement for the Alpha-X project.

Conceivability and De Re Modal Knowledge: A reply to Roca-Royes

DEFF Research Database (Denmark)

Steffensen, Asger Bo Skjerning

In a recent paper, Roca-Royes argues that conceivability cannot be the whole story about our access to de re modal knowledge. Her claim is that conceivability-based epistemologies fails to comply with a principle any epistemology of de re modality must observe. I critically assess Roca...

COMPLEX STAGING : THE HIDDEN DIMENSIONS OF ROY ANDERSSON’S AESTHETICS

NARCIS (Netherlands)

Hanich, Julian

2014-01-01

In this essay I follow André Bazin and David Bordwell and their discussion of the deep-focus long-take as well as staging in depth. I have three goals. First, I engage with the style of Swedish director Roy Andersson. Andersson – born in 1943 and best known for his films Songs from the Second Floor

Grid Integration of PV Power based on PHIL testing using different Interface Algorithms

DEFF Research Database (Denmark)

Craciun, Bogdan-Ionut; Kerekes, Tamas; Sera, Dezso

2013-01-01

to be more active in grid support. Therefore, a better understanding and detailed analysis of the PV systems interaction with the grid is needed; hence power hardware in the loop (PHIL) testing involving PV power became an interesting subject to look into. To test PV systems for grid code (GC) compliance......Photovoltaic (PV) power among all renewable energies had the most accelerated growth rate in terms of installed capacity in recent years. Transmission System Operators (TSOs) changed their perspective about PV power and started to include it into their planning and operation, imposing PV systems...

Roy Reider (1914-1979) selections from his written and spoken words

International Nuclear Information System (INIS)

Paxton, H.C.

1980-01-01

Comments by Roy Reider on chemical criticality control, the fundamentals of safety, policy and responsibility, on written procedures, profiting from accidents, safety training, early history of criticality safety, requirements for the possible, the value of enlightened challenge, public acceptance of a new risk, and on prophets of doom are presented

Pessoas com úlceras venosas: estudo do modo psicossocial do modelo adaptativo de Roy Personas con úlceras venosas: estudio de los aspectos psicosociales del modelo de adaptación de Roy People with venous ulcers: a study of the psychosocial aspects of the adaptive model of Roy

Directory of Open Access Journals (Sweden)

Isabelle Katherinne Fernandes Costa

2011-09-01

Full Text Available Estudo transversal, descritivo, quantitativo, realizado com 50 pessoas com úlcera venosa (UV em um Hospital Universitário, que objetivou verificar o nível de adaptação psicossocial do Modelo de Roy das pessoas com UV. A pesquisa foi aprovada pelo Comitê de Ética da instituição. Os dados foram coletados com formulário estruturado e após a organização dos dados das alterações ocorridas na vida das pessoas com UV classificamos segundo o modo psicossocial de Roy. Verificamos que no modo autoconceito, 36% sentiam-se insatisfeitos com aparência física, 18% apresentavam sentimentos negativos; no modo desempenho de papéis: alteração no papel laboral (52,0%, atividades domésticas (34,0%, conjugal (6,0%, restrições de lazer, dor, social, escolar e locomoção (82,0%; no modo de interdependência: apoio no tratamento (82,0%, discriminação (58,0%. A identificação do modo psicossocial direciona as ações de enfermagem abrangendo a pessoa que recebe o cuidado considerando-a no todo em suas relações com ambiente promovendo melhor nível de adaptação.Estudio transversal, descriptivo, cuantitativo realizado con 50 personas con úlcera venosa (UV en el Hospital Universitario que objetivó conocer nivel de adaptación psicosocial del modelo de Roy de las personas con UV. Estudio aprobado por el Comité de Ética (nº 279/09. Los datos fueron recogidos mediante formulario y después de organizar los datos de los cambios en la vida de las personas con UV, fueron clasificados de acuerdo con los aspectos psicosociales de Roy. Verificamos en el modo de auto-concepto: 36% insatisfacción con apariencia física, 18% sentimientos negativos, desempeño de papel: cambio en el papel de trabajo (52,0%, tareas domésticas (34,0%, estado civil (6,0%, restricción de ocio, dolor, sociales, educativos y transporte (82,0%; modo de interdependencia: apoyo en el tratamiento (82,0%, discriminación (58,0%. La identificación de aspectos psicosociales

The Roy Adaptation Model: A Theoretical Framework for Nurses Providing Care to Individuals With Anorexia Nervosa.

Science.gov (United States)

Jennings, Karen M

Using a nursing theoretical framework to understand, elucidate, and propose nursing research is fundamental to knowledge development. This article presents the Roy Adaptation Model as a theoretical framework to better understand individuals with anorexia nervosa during acute treatment, and the role of nursing assessments and interventions in the promotion of weight restoration. Nursing assessments and interventions situated within the Roy Adaptation Model take into consideration how weight restoration does not occur in isolation but rather reflects an adaptive process within external and internal environments, and has the potential for more holistic care.

PLURALISM, FATWA, AND COURT IN INDONESIA: The Case of Yusman Roy

Directory of Open Access Journals (Sweden)

Nadirsyah Hosen

2012-06-01

Full Text Available The interrelation between Islam, state and pluralism is an unfinished discussion in Indonesia. This paper examines an issue of promoting individual freedom to practice his/her belief, and at the same time not insulting the majority belief in a plural society. It takes the case of Yusman Roy on performing the salah (prayer in a local language as the subject of analysis in order to identify the fault lines of religion and pluralism, and to consider how best to address them. The paper argues that fatwa and court should not be used as mechanisms to deal with the issue of religion and pluralism. It further argues for an “alternative dispute resolution” in dealing with the plurality of interpretation within Islamic tradition and at the same time maintaining the unity and harmony Islamic communities. It maintains that Roy should have the rights to practice what he believes, but at the same time, a negotiation on how he spreads his ideas outside his schools should take place in order to avoid provocative actions that invite violence.

Anti-inflammatory activity of copao (Eulychnia acida Phil., Cactaceae) fruits.

Science.gov (United States)

Jiménez-Aspee, Felipe; Alberto, Maria Rosa; Quispe, Cristina; Soriano, Maria del Pilar Caramantin; Theoduloz, Cristina; Zampini, Iris Catiana; Isla, Maria Ines; Schmeda-Hirschmann, Guillermo

2015-06-01

Copao (Eulychnia acida Phil., Cactaceae) is an endemic species occurring in northern Chile. The edible fruits of this plant are valued for its acidic and refreshing taste. Phenolic-enriched extracts from copao fruit pulp and epicarp, collected in the Elqui and Limari river valleys, were assessed by its in vitro ability to inhibit the pro-inflammatory enzymes lipoxygenase (LOX) and cyclooxygenases (COX-1 and COX-2). At 100 μg/mL, pulp extracts showed better effect towards LOX than epicarp extract, while COX-2 inhibition was observed for both epicarp and pulp samples. In general, the extracts were inactive towards COX-1. A positive correlation was observed between the anti-inflammatory activity and the main phenolic compounds found in this fruit. Copao fruits from the Limari valley, a main place of collection and commercialization, showed major activity, adding evidence on the possible health-beneficial effects of this native Chilean fruit.

Estudio de la evidencia del concepto de grupo en el modelo de adaptación de Roy

OpenAIRE

Cavalcante Guedes, María Vilaní; Lopes, Marcos Venícios de Oliveira; Araujo, Thelma Leite de

2005-01-01

El estudio tiene como objetivo evaluar el concepto de grupo en el Modelo de Adaptación de Roy tomando por parámetro el criterio interno de evidencia del modelo de análisis de teoría propuesto por Barnum (1998). Discutimos el concepto de grupo con base en diferentes autores, y también según descrito por Roy en sus diversos modos de adaptación. Encontramos que la evidencia del concepto grupo, en los modos de adaptación, se quedó perjudicada y que el Modelo Teórico ...

Why developmental psychology is incomplete without comparative and cross-cultural perspectives

Science.gov (United States)

Nielsen, Mark; Haun, Daniel

2016-01-01

As a discipline, developmental psychology has a long history of relying on animal models and data collected among distinct cultural groups to enrich and inform theories of the ways social and cognitive processes unfold through the lifespan. However, approaches that draw together developmental, cross-cultural and comparative perspectives remain rare. The need for such an approach is reflected in the papers by Heyes (2015 Phil. Trans. R. Soc. B 371, 20150069. (doi:10.1098/rstb.2015.0069)), Schmelz & Call (2015 Phil. Trans. R. Soc. B 371, 20150067. (doi:10.1098/rstb.2015.0067)) and Keller (2015 Phil. Trans. R. Soc. B 371, 20150070. (doi:10.1098/rstb.2015.0070)) in this theme issue. Here, we incorporate these papers into a review of recent research endeavours covering a range of core aspects of social cognition, including social learning, cooperation and collaboration, prosociality, and theory of mind. In so doing, we aim to highlight how input from comparative and cross-cultural empiricism has altered our perspectives of human development and, in particular, led to a deeper understanding of the evolution of the human cultural mind. PMID:26644590

Why developmental psychology is incomplete without comparative and cross-cultural perspectives.

Science.gov (United States)

Nielsen, Mark; Haun, Daniel

2016-01-19

As a discipline, developmental psychology has a long history of relying on animal models and data collected among distinct cultural groups to enrich and inform theories of the ways social and cognitive processes unfold through the lifespan. However, approaches that draw together developmental, cross-cultural and comparative perspectives remain rare. The need for such an approach is reflected in the papers by Heyes (2015 Phil. Trans. R. Soc. B 371, 20150069. (doi:10.1098/rstb.2015.0069)), Schmelz & Call (2015 Phil. Trans. R. Soc. B 371, 20150067. (doi:10.1098/rstb.2015.0067)) and Keller (2015 Phil. Trans. R. Soc. B 371, 20150070. (doi:10.1098/rstb.2015.0070)) in this theme issue. Here, we incorporate these papers into a review of recent research endeavours covering a range of core aspects of social cognition, including social learning, cooperation and collaboration, prosociality, and theory of mind. In so doing, we aim to highlight how input from comparative and cross-cultural empiricism has altered our perspectives of human development and, in particular, led to a deeper understanding of the evolution of the human cultural mind. © 2015 The Author(s).

On exact solutions for disturbances to the asymptotic suction boundary layer: transformation of Barnes integrals to convolution integrals

Science.gov (United States)

Russell, John

2000-11-01

A modified Orr-Sommerfeld equation that applies to the asymptotic suction boundary layer was reported by Bussmann & Münz in a wartime report dated 1942 and by Hughes & Reid in J.F.M. ( 23, 1965, p715). Fundamental systems of exact solutions of the Orr-Sommerfeld equation for this mean velocity distribution were reported by D. Grohne in an unpublished typescript dated 1950. Exact solutions of the equation of Bussmann, Münz, Hughes, & Reid were reported by P. Baldwin in Mathematika ( 17, 1970, p206). Grohne and Baldwin noticed that these exact solutions may be expressed either as Barnes integrals or as convolution integrals. In a later paper (Phil. Trans. Roy. Soc. A, 399, 1985, p321), Baldwin applied the convolution integrals in the contruction of large-Reynolds number asymptotic approximations that hold uniformly. The present talk discusses the subtleties that arise in the construction of such convolution integrals, including several not reported by Grohne or Baldwin. The aim is to recover the full set of seven solutions (one well balanced, three balanced, and three dominant-recessive) postulated by W.H. Reid in various works on the uniformly valid solutions.

Transport of temperature-velocity covariance in gas-solid flow and its relation to the axial dispersion coefficient

Science.gov (United States)

Subramaniam, Shankar; Sun, Bo

2015-11-01

The presence of solid particles in a steady laminar flow generates velocity fluctuations with respect to the mean fluid velocity that are termed pseudo-turbulence. The level of these pseudo-turbulent velocity fluctuations has been characterized in statistically homogeneous fixed particle assemblies and freely evolving suspensions using particle-resolved direct numerical simulation (PR-DNS) by Mehrabadi et al. (JFM, 2015), and it is found to be a significant contribution to the total kinetic energy associated with the flow. The correlation of these velocity fluctuations with temperature (or a passive scalar) generates a flux term that appears in the transport equation for the average fluid temperature (or average scalar concentration). The magnitude of this transport of temperature-velocity covariance is quantified using PR-DNS of thermally fully developed flow past a statistically homogeneous fixed assembly of particles, and the budget of the average fluid temperature equation is presented. The relation of this transport term to the axial dispersion coefficient (Brenner, Phil. Trans. Roy. Soc. A, 1980) is established. The simulation results are then interpreted in the context of our understanding of axial dispersion in gas-solid flow. NSF CBET 1336941.

Evolução histórica do conceito ambiente proposto no modelo da adaptação de Roy

OpenAIRE

Lopes, Marcos Venícios de Oliveira; Pagliuca, Lorita Marlena Freitag; Araujo, Thelma Leite de

2006-01-01

The concern for the development of concepts becomes even more important when we report to its use in Nursing theories, in which some concepts are considered central, such as person, environment, health and nursing. This study aims to discuss the historical evolution of the environment concept used in the Roy Adaptation Model. The method of analysis the study was based on is the evolutionary conceptual analysis of the concept Environment of the Roy Adaptation Model. According to the research r...

Understanding the nineteenth century origins of disciplines: lessons for astrobiology today?

Science.gov (United States)

Brazelton, William J.; Sullivan, Woodruff T., III

2009-10-01

Astrobiology's goal of promoting interdisciplinary research is an attempt to reverse a trend that began two centuries ago with the formation of the first specialized scientific disciplines. We have examined this era of discipline formation in order to make a comparison with the situation today in astrobiology. Will astrobiology remain interdisciplinary or is it becoming yet another specialty? As a case study, we have investigated effects on the scientific literature when a specialized community is formed by analyzing the citations within papers published during 1802-1856 in Philosophical Transactions of the Royal Society (Phil. Trans.), the most important ‘generalist’ journal of its day, and Transactions of the Geological Society of London (Trans. Geol. Soc.), the first important disciplinary journal in the sciences. We find that these two journals rarely cited each other, and papers published in Trans. Geol. Soc. cited fewer interdisciplinary sources than did geology papers in Phil. Trans. After geology had become established as a successful specialized discipline, geologists returned to publishing papers in Phil. Trans., but they wrote in the new, highly specialized style developed in Trans. Geol. Soc. They had succeeded in not only creating a new scientific discipline, but also a new way of doing science with its own modes of research and communication. A similar citation analysis was applied to papers published over the period 2001-2008 in the contemporary journals Astrobiology and the International Journal of Astrobiology to test the hypothesis that astrobiologists are in the early stages of creating their own specialized community. Although still too early to reliably detect any but the largest trends, there is no evidence yet that astrobiologists are drifting into their own isolated discipline. Instead, to date they appear to remain interdisciplinary.

Roy-Steiner-equation analysis of pion-nucleon scattering

Science.gov (United States)

Meißner, U.-G.; Ruiz de Elvira, J.; Hoferichter, M.; Kubis, B.

2017-03-01

Low-energy pion-nucleon scattering is relevant for many areas in nuclear and hadronic physics, ranging from the scalar couplings of the nucleon to the long-range part of two-pion-exchange potentials and three-nucleon forces in Chiral Effective Field Theory. In this talk, we show how the fruitful combination of dispersion-theoretical methods, in particular in the form of Roy-Steiner equations, with modern high-precision data on hadronic atoms allows one to determine the pion-nucleon scattering amplitudes at low energies with unprecedented accuracy. Special attention will be paid to the extraction of the pion-nucleon σ-term, and we discuss in detail the current tension with recent lattice results, as well as the determination of the low-energy constants of chiral perturbation theory.

DIAGNÓSTICOS DE ENFERMAGEM E MODELO TÉORICO DE ROY EM PACIENTES PROSTATECTOMIZADOS

Directory of Open Access Journals (Sweden)

Elisandra de Araújo Saldanha

2013-01-01

Full Text Available Estudio descriptivo, con objetivo de identificar el perfil de los diagnósticos de enfermería internacional NANDA en pacientes en postoperatorio inmediato de prostatectomía y relacionarlos con los problemas de adaptación del Modelo de Adaptación de Roy. Llevado a cabo en hospital universitario en Nordeste de Brasil, entre noviembre/2010 y abril/2011, con muestra de 50 individuos. Los datos fueron recolectados a través de entrevista y examen físico, con posterior análisis por medio del razonamiento clínico. Fueron encontrados las relaciones: riesgo de caídas y posibles lesiones; alteración de la deambulación y la movilidad a pie y/o coordinación restringida; déficits de autocuidado y pérdida de la capacidad de autocuidado; dolor agudo y dolor agudo; patrones de insomnio/sueño y privación del sueño con discapacidad; estreñimiento y estreñimiento. Por lo tanto, la mayor parte de los diagnósticos de enfermería identificados son similares a los problemas de adaptación de acuerdo con Roy.

Diagnósticos de enfermagem e modelo adaptativo de Roy: análise em pacientes críticos

Directory of Open Access Journals (Sweden)

Anna Lívia de Medeiros Dantas

2017-01-01

Full Text Available Objetivo: establecer relación de los diagnósticos de enfermería presentes en el dominio seguridad y protección de NANDA Internacional con los problemas adaptativos del modelo de Roy para pacientes en unidad de cuidados intensivos (UCI. Métodos: estudio transversal, llevado a cabo en la UCI de un hospital universitario en una capital del noreste brasileño. La muestra fue de 86 individuos. Los datos, recolectados entre octubre del 2013 y mayo del 2014, mediante formato de entrevista y prueba física, se analizaron por medio de estadística descriptiva e inferencial. Resultados: entre los diagnósticos de enfermería del dominio seguridad y protección, 29 estuvieron presentes con frecuencias variables. En cuanto a los relacionados con los problemas adaptativos propuestos por Roy, se evidenciaron 12 problemas adaptativos en cuanto al modo adaptativo fisiológico, que abarca las categorías de sentidos, protección, oxigenación, actividad y reposo y nutrición. Conclusiones: se encontró relación entre los diagnósticos de enfermería del dominio seguridad y protección y los problemas adaptativos del modelo de Roy para pacientes en cuidados intensivos.

CERN Library | Roy Calne presents: "The Ratchet of Science - Curiosity killed the cat" | 26 October

CERN Multimedia

CERN Library

2015-01-01

Sir Roy Calne will discuss his most recent book: “The Ratchet of Science - Curiosity killed the cat. Can human nature cope with the rapid and accelerated advances of science?”   Monday, 26 October - 4.30 p.m. CERN Filtration plant, Room 222-R-001 There is a limited number of seats. Please register here. The book’s premise is that huge scientific advances throughout history occur in spurts or “ratchets”. It reflects on the good and the evil consequences of discoveries. Due to the worrying nature of human beings, each ratchet in our knowledge is too often accompanied by dangerous applications. Knowledge, once established by a reliable scientific method, cannot be unlearned. The cat is out of the bag and the curiosity may kill the cat – so to speak. Professor Roy Calne illustrates this with the example of the young physicist known to all at CERN: Lise Meitner, who discovered and named nucle...

[People with venous ulcers: a study of the psychosocial aspects of the Roy Adaptation Model].

Science.gov (United States)

Costa, Isabelle Katherinne Fernandes; da Nóbrega, Walkíria Gomes; Costa, Isabel Karolyne Fernandes; Torres, Gilson de Vasconcelos; Lira, Ana Luiza Brandão de Carvalho; Tourinho, Francis Solange Vieira; Enders, Bertha Cruz

2011-09-01

A transversal descriptive quantitative study, conducted with 50 people with Venous Ulcer (VU) at an University Hospital, that aimed to ascertain the level of psychosocial adaptation of the Roy Model of people with VU. The study was approved by the Ethics Committee. The data were collected with a structured form. After organizing the data, composed of changes in the lives of people with VU, we classified it according to Roy's psychosocial aspects. We found that in the self-concept mode, 36% felt dissatisfied with physical appearance, and 18% had negative feelings; in the role-function mode: change in the working role (52.0%), housework (34.0%), marital (6.0%), leisure, pain, social, educational and transportation restrictions (82.0%); interdependence mode: support in treatment (82.0%), discrimination (58.0%). The identification of the psychosocial aspects directs nursing actions to consider the whole of the person receiving care in its relations with the environment, thus promoting a better level of adaptation.

Método canguru: práticas investigativas e de cuidado de enfermagem no modelo de adaptação de Roy Método canguro: prácticas de investigación y de atención en enfermería en el modelo de adaptación de Roy Kangaroo method: investigative practices and nursing care in the Roy adaptation model

Directory of Open Access Journals (Sweden)

Márcia Borck

2012-06-01

Full Text Available Trata-se de uma pesquisa convergente-assistencial, de natureza qualitativa, que teve como objetivos: investigar a experiência no processo de adaptação de seis famílias na terceira etapa do Método Canguru com recém-nascidos pré-termo e/ou de baixo peso, no período de outubro/06 a fevereiro/07; e implementar a consulta de enfermagem dentro dos quatro modos adaptativos da Teoria de Roy. A coleta de dados foi realizada através do processo de cuidar do modelo adaptativo de Roy, utilizando as técnicas de observação e da entrevista semiestruturada. O processo de análise ocorreu por meio da apreensão, síntese, teorização e transferência. Os resultados mostram a necessidade de fortalecer o papel da família na desospitalização e a comunicação entre a equipe interdisciplinar e rever critérios de alta da terceira etapa. Este estudo evidencia a terceira etapa como oportunidade para retroalimentar o sistema de cuidado e apoiar as famílias para sobreporem seus conflitos, preocupações, medos, inseguranças e o próprio comportamento imaturo do bebê.Se trata de una Investigación Convergente y Asistencial, cualitativa. Sus objetivos fueron investigar la experiencia en el proceso de adaptación de seis familias en la tercera etapa del Método Canguro con recién nacidos pre término y/o de bajo peso, en el periodo de Octubre /06 a Febrero /07 e implementar la consulta de enfermería dentro de los cuatro modos adaptativos de la Teoría de Roy. La recolección de los datos fue realizada a través del proceso de cuidar del modelo adaptativo de Roy, utilizando las técnicas de observación y la entrevista parcialmente estructurada. El proceso de análisis se hizo por medio de la aprehensión, síntesis, teorización y transferencia. Los resultados muestran la necesidad de fortalecer el papel de la familia en la deshospitalización, la comunicación entre el equipo disciplinario y rever criterios de alta de la tercera etapa. En este estudio

Roy-Steiner equations for pion-nucleon scattering

Science.gov (United States)

Ditsche, C.; Hoferichter, M.; Kubis, B.; Meißner, U.-G.

2012-06-01

Starting from hyperbolic dispersion relations, we derive a closed system of Roy-Steiner equations for pion-nucleon scattering that respects analyticity, unitarity, and crossing symmetry. We work out analytically all kernel functions and unitarity relations required for the lowest partial waves. In order to suppress the dependence on the high energy regime we also consider once- and twice-subtracted versions of the equations, where we identify the subtraction constants with subthreshold parameters. Assuming Mandelstam analyticity we determine the maximal range of validity of these equations. As a first step towards the solution of the full system we cast the equations for the π π to overline N N partial waves into the form of a Muskhelishvili-Omnès problem with finite matching point, which we solve numerically in the single-channel approximation. We investigate in detail the role of individual contributions to our solutions and discuss some consequences for the spectral functions of the nucleon electromagnetic form factors.

Roy's safety-first portfolio principle in financial risk management of disastrous events.

Science.gov (United States)

Chiu, Mei Choi; Wong, Hoi Ying; Li, Duan

2012-11-01

Roy pioneers the concept and practice of risk management of disastrous events via his safety-first principle for portfolio selection. More specifically, his safety-first principle advocates an optimal portfolio strategy generated from minimizing the disaster probability, while subject to the budget constraint and the mean constraint that the expected final wealth is not less than a preselected disaster level. This article studies the dynamic safety-first principle in continuous time and its application in asset and liability management. We reveal that the distortion resulting from dropping the mean constraint, as a common practice to approximate the original Roy's setting, either leads to a trivial case or changes the problem nature completely to a target-reaching problem, which produces a highly leveraged trading strategy. Recognizing the ill-posed nature of the corresponding Lagrangian method when retaining the mean constraint, we invoke a wisdom observed from a limited funding-level regulation of pension funds and modify the original safety-first formulation accordingly by imposing an upper bound on the funding level. This model revision enables us to solve completely the safety-first asset-liability problem by a martingale approach and to derive an optimal policy that follows faithfully the spirit of the safety-first principle and demonstrates a prominent nature of fighting for the best and preventing disaster from happening. © 2012 Society for Risk Analysis.

The Generalized Roy Model and the Cost-Benefit Analysis of Social Programs*

Science.gov (United States)

Eisenhauer, Philipp; Heckman, James J.; Vytlacil, Edward

2015-01-01

The literature on treatment effects focuses on gross benefits from program participation. We extend this literature by developing conditions under which it is possible to identify parameters measuring the cost and net surplus from program participation. Using the generalized Roy model, we nonparametrically identify the cost, benefit, and net surplus of selection into treatment without requiring the analyst to have direct information on the cost. We apply our methodology to estimate the gross benefit and net surplus of attending college. PMID:26709315

The Generalized Roy Model and the Cost-Benefit Analysis of Social Programs.

Science.gov (United States)

Eisenhauer, Philipp; Heckman, James J; Vytlacil, Edward

2015-04-01

The literature on treatment effects focuses on gross benefits from program participation. We extend this literature by developing conditions under which it is possible to identify parameters measuring the cost and net surplus from program participation. Using the generalized Roy model, we nonparametrically identify the cost, benefit, and net surplus of selection into treatment without requiring the analyst to have direct information on the cost. We apply our methodology to estimate the gross benefit and net surplus of attending college.

Roy-Steiner equations for {pi}N scattering - The Muskhelishvili-Omnes problem for the t-channel partial waves

Energy Technology Data Exchange (ETDEWEB)

Ditsche, Christoph; Hoferichter, Martin; Kubis, Bastian [Helmholtz-Institut fuer Strahlen- und Kernphysik (Theorie), Universitaet Bonn (Germany); Bethe Center for Theoretical Physics, Bonn (Germany); Meissner, Ulf G. [Helmholtz-Institut fuer Strahlen- und Kernphysik (Theorie), Universitaet Bonn (Germany); Institut fuer Kernphysik (Theorie), Institute for Advanced Simulations, and Juelich Center for Hadron Physics, Forschungszentrum Juelich, D-52425 Juelich (Germany); Bethe Center for Theoretical Physics, Bonn (Germany)

2011-07-01

Starting from (subtracted) hyperbolic dispersion relations for {pi}N scattering, which are based on the general principles of Lorentz invariance, unitarity, crossing and analyticity as well as isospin symmetry, we propose a closed system of (subtracted) hyperbolic partial wave dispersion relations for the partial waves f{sup I}{sub l{+-}}({radical}(s)) of the s-channel reaction {pi}N{yields}{pi}N and the partial waves f{sup J}{sub {+-}}(t) of the t-channel reaction {pi}{pi}{yields} anti NN in the spirit of Roy and Steiner. A key step to the ultimate goal of solving this Roy-Steiner system is to first solve the corresponding (subtracted) Muskhelishvili-Omnes problem with inelasticities and a finite matching point for the lowest t-channel partial waves f{sup 0}{sub +}(t), f{sup 1}{sub {+-}}(t). The recent status of this ongoing effort is presented.

Effect of a care plan based on Roy adaptation model biological dimension on stroke patients' physiologic adaptation level.

Science.gov (United States)

Alimohammadi, Nasrollah; Maleki, Bibi; Shahriari, Mohsen; Chitsaz, Ahmad

2015-01-01

Stroke is a stressful event with several functional, physical, psychological, social, and economic problems that affect individuals' different living balances. With coping strategies, patients try to control these problems and return to their natural life. The aim of this study is to investigate the effect of a care plan based on Roy adaptation model biological dimension on stroke patients' physiologic adaptation level. This study is a clinical trial in which 50 patients, affected by brain stroke and being admitted in the neurology ward of Kashani and Alzahra hospitals, were randomly assigned to control and study groups in Isfahan in 2013. Roy adaptation model care plan was administered in biological dimension in the form of four sessions and phone call follow-ups for 1 month. The forms related to Roy adaptation model were completed before and after intervention in the two groups. Chi-square test and t-test were used to analyze the data through SPSS 18. There was a significant difference in mean score of adaptation in physiological dimension in the study group after intervention (P adaptation in the patients affected by brain stroke in the study and control groups showed a significant increase in physiological dimension in the study group by 47.30 after intervention (P adaptation model biological dimension care plan can result in an increase in adaptation in patients with stroke in physiological dimension. Nurses can use this model for increasing patients' adaptation.

Trans fatty acid isomers and the trans-9/trans-11 index in fat containing foods

Science.gov (United States)

Kuhnt, Katrin; Baehr, Melanie; Rohrer, Carsten; Jahreis, Gerhard

2011-01-01

To determine trans fatty acid (TFA) distribution of contemporary foods, especially regarding individual trans octadecenoic acids (trans C18:1), 339 German foods of six categories (semi-solid fats, deep-fried potato products, bakery products, confectioneries, instant products and butter) were analysed using two GC methods. Results showed a high variation of TFA content between and within the categories containing between 0 and 40.5% of FAME except in butter, which is a source of natural TFA. The mean TFA values were below 2.0% of FAME, however, bakery products contained 4.5% and butter fat 3.2%, respectively. In addition, the distribution of individual trans C18:1 differed. In samples containing ruminant fat (butter and various confectioneries), vaccenic acid (t11-C18:1, t11) predominated, while in foods containing industrially hydrogenated fats, elaidic acid (trans-9, t9-) and t10-C18:1 were the major trans isomers.. This was reflected by a low t9/t11 index of 0.3 and 0.5 in butter and ruminant fat containing confectioneries, respectively, whilst the highest index was observed in shortenings and deep-fried potato products at 5.2 and 6.8, respectively. In conclusion, the TFA content of foods available on the German market is generally declining, but substantial variations are present. The t9/t11 index could be used as an indicator to determine ruminant fat. Practical applications: A number of studies provide evidence that a high TFA intake, particularly of industrial origin, adversely affects human health. The TFA content of foods could be reduced due to the introduction of several mandatory regulations and modifications regarding the hydrogenation process of oils. The most abundant dietary TFA are the isomers of trans C18:1. Unfortunately, the differentiation of these isomers is not yet very common, though the trans C18:1 profile differs depending on its origin (bacterial hydrogenation in the rumen or industrial hydrogenation). To date, data for TFA content

Matching Pion-Nucleon Roy-Steiner Equations to Chiral Perturbation Theory

Science.gov (United States)

Hoferichter, Martin; Ruiz de Elvira, Jacobo; Kubis, Bastian; Meißner, Ulf-G.

2015-11-01

We match the results for the subthreshold parameters of pion-nucleon scattering obtained from a solution of Roy-Steiner equations to chiral perturbation theory up to next-to-next-to-next-to-leading order, to extract the pertinent low-energy constants including a comprehensive analysis of systematic uncertainties and correlations. We study the convergence of the chiral series by investigating the chiral expansion of threshold parameters up to the same order and discuss the role of the Δ (1232 ) resonance in this context. Results for the low-energy constants are also presented in the counting scheme usually applied in chiral nuclear effective field theory, where they serve as crucial input to determine the long-range part of the nucleon-nucleon potential as well as three-nucleon forces.

Trans-Planckian wimpzillas

CERN Document Server

Kolb, E W; Tkachev, I I

2007-01-01

Two previously proposed conjectures--gravitational trans-Planckian particle creation in the expanding universe, and the existence of ultra-heavy stable particles with masses up to the Planck scale (wimpzillas)--are combined in a proposal for trans-Planckian particle creation of wimpzillas. It is shown that the trans-Planckian particle creation parameter should be rather small to avoid overproduction of such particles. This ensures that wimpzillas are mainly created at the end of primordial inflation. Conditions under which trans-Planckian wimpzillas can constitute the present dark matter are determined.

Effect of Trans, Trans-Farnesol on Pseudogymnoascus destructans and Several Closely Related Species.

Science.gov (United States)

Raudabaugh, Daniel B; Miller, Andrew N

2015-12-01

Bat white-nose syndrome, caused by the psychrophilic fungus Pseudogymnoascus destructans, has dramatically reduced the populations of many hibernating North American bat species. The search for effective biological control agents targeting P. destructans is of great importance. We report that the sesquiterpene trans, trans-farnesol, which is also a Candida albicans quorum sensing compound, prevented in vitro conidial germination for at least 14 days and inhibited growth of preexisting hyphae of five P. destructans isolates in filtered potato dextrose broth at 10 °C. Depending on the inoculation concentrations, both spore and hyphal inhibition occurred upon exposure to concentrations as low as 15-20 µM trans, trans-farnesol. In contrast, most North American Pseudogymnoascus isolates were more tolerant to the exposure of trans, trans-farnesol. Our results suggest that some Candida isolates may have the potential to inhibit the growth of P. destructans and that the sesquiterpene trans, trans-farnesol has the potential to be utilized as a biological control agent.

Influence of temperature on the starvation threshold of nauplii of barnacle Balanus amphitrite (Cirripedia: Thoracica)

Digital Repository Service at National Institute of Oceanography (India)

Desai, D.V.; Anil, A.C.

& Rohlf F J , Biometry: The principles and practice of statistics in biological research , (W H Freeman & Comp, San Francisco), 1981. 12 Walley L J, Phil. Trans. R. Soc. (B).256 (1969) 237. 13 Storch V & Anger K, Helgolander Meeresunters, 36 (1983) 67. 14...

Pion-nucleon scattering: from chiral perturbation theory to Roy-Steiner equations

Science.gov (United States)

Kubis, Bastian; Hoferichter, Martin; de Elvira, Jacobo Ruiz; Meißner, Ulf-G.

2016-11-01

Ever since Weinberg's seminal predictions of the pion-nucleon scattering amplitudes at threshold, this process has been of central interest for the study of chiral dynamics involving nucleons. The scattering lengths or the pion-nucleon σ-term are fundamental quantities characterizing the explicit breaking of chiral symmetry by means of the light quark masses. On the other hand, pion-nucleon dynamics also strongly affects the long-range part of nucleon-nucleon potentials, and hence has a far-reaching impact on nuclear physics. We discuss the fruitful combination of dispersion-theoretical methods, in the form of Roy-Steiner equations, with chiral dynamics to determine pion-nucleon scattering amplitudes at low energies with high precision.*

Acute oral toxicity and anti-inflammatory activity of hydroalcoholic extract from Lampaya medicinalis Phil in rats.

Science.gov (United States)

Morales, Glauco; Paredes, Adrián; Olivares, Alberto; Bravo, Jaime

2014-03-26

Algesia and inflammation are related with several pathological conditions. It is known that many drugs available for the treatment of these problems cause unwanted side effects. This study was aimed at evaluating acute toxicity and anti-inflammatory activity of Lampaya medicinalis Phil. (Verbenaceae) widely used in the folk medicine of Northern Chile against rheumatism, arthritis and body joints pain. Oral administration of hydroalcoholic extract (HAE) at the highest dose of 3000 mg/ Kg body weight resulted in no mortalities or evidence of significant behavioral changes. Histological examination revealed normal architecture and no significant adverse effects were observed on the liver, kidney, heart, lung or ovaries and testicles. The results suggest that the oral administration of hydroalcoholic extract (HAE) from Lampaya medicinalis did not produce any toxic effect in rats. Hydroalcoholic extract (HAE) significantly inhibited the carrageenan-induced rat paw edema in dose - response relationship, at test doses of 37.5, 75, 150 and 300 mg/Kg body weight. Maximum inhibition (61.98 ± 2.69%) was noted at 300 mg/Kg after 2 h of drug treatment carrageenan induced paw edema, whereas indomethacin produced 47.90 ± 1.16% of inhibition. The inhibitory values of edema at 3 h postcarrageenan were 31.04 ± 0.75%, 40.51 ± 2.36%, 48.97 ± 1.14% and 56.87 ± 0.41% for 37.5, 75, 150, and 300 mg/kg of extract respectively. Indomethacin (10 mg/Kg) gave a percentage inhibition of 49.44 ± 1.44. HAE (300 and 150 mg/kg) induced an anti-inflammatory effect greater than (or comparable) with the effect of indomethacin from 2nd to 4th hours of the experiment. Our results reveal for first time that compounds contained in the hydroalcoholic extract of Lampaya medicinalis Phil exert anti-inflammatory effect and the oral administration is safe and non toxic up to dose level 3000 mg/kg body weight. The anti-inflammatory activity may be associated with the presence of flavonoids. These

Dr Phil Mjwara Director General, Department of Science and Technology (DST) Ministry of Science and Technology Republic of South Africa visit the Alice experiment introduce by Prof. Jurgen Schukraft, spokeperson for Alice.

CERN Multimedia

Maximilien Brice

2007-01-01

Dr Phil Mjwara Director General, Department of Science and Technology (DST) Ministry of Science and Technology Republic of South Africa visit the Alice experiment introduce by Prof. Jurgen Schukraft, spokeperson for Alice.

Trans-Cultural, Trans-Language Practices: Potentialities for Rethinking Doctoral Education Pedagogies

Directory of Open Access Journals (Sweden)

Sarojni Choy

2017-01-01

Full Text Available Over the last decade, there has been a rapid increase in doctoral enrolments of Asian international students in Australian universities. While policies have been developed to meet the needs of these students, there seems to be some confusion around the terms internationalisation, globalisation, bi-cultural, inter-cultural, multi-cultural, and trans-cultural within these policies. In this paper, we define these terms and advocate for a policy position which orients to a futurist definition of culture. We then review the work of Michael Singh and his research team at Western Sydney University who have responded to this rapid increase in Asian international student doctoral enrolments in Australian universities by developing pedagogic principles around notions of trans-language and trans-cultural practices. In the final section of the paper, we then draw on our own experiences of doctoral supervision in Australian universities to reflect on our positioning within the pedagogic principles around trans-language and trans-cultural practices.

Effect of Roy's Adaptation Model-Guided Education on Coping Strategies of the Veterans with Lower Extremities Amputation: A Double-Blind Randomized Controlled Clinical Trial.

Science.gov (United States)

Farsi, Zahra; Azarmi, Somayeh

2016-04-01

Any defect in the extremities of the body can affect different life aspects. The purpose of this study was to investigate the effect of Roy's adaptation model-guided education on coping strategies of the veterans with lower extremities amputation. In a double-blind randomized controlled clinical trial, 60 veterans with lower extremities amputation referring to Kowsar Orthotics and Prosthetics Center of Veterans Clinic in Tehran, Iran were recruited using convenience method and randomly assigned to intervention and control groups in 2013-2014. Lazarus and Folkman coping strategies questionnaire was used to collect the data. After completing the questionnaires in both groups, maladaptive behaviours were determined in the intervention group and an education program based on Roy's adaptation model was implemented. After 2 months, both groups completed the questionnaires again. Data were analyzed using SPSS software. Independent T-test showed that the score of the dimensions of coping strategies did not have a statistically significant difference between the intervention and control groups in the pre-intervention stage (P>0.05). This test showed a statistically significant difference between the two groups in the post-intervention stage in terms of the scores of different dimensions of coping strategies (P>0.05), except in dimensions of social support seeking and positive appraisal (P>0.05). The findings of this research indicated that the Roy's adaptation model-guided education improved the majority of coping strategies in veterans with lower extremities amputation. It is recommended that further interventions based on Roy's adaptation model should be performed to improve the coping of the veterans with lower extremities amputation. IRCT2014081118763N1.

Trans* Leadership.

Science.gov (United States)

Jourian, T J; Simmons, Symone L

2017-06-01

Focusing on emerging literature on trans* and gender-nonconforming students and their leadership, this chapter outlines the ways trans* students are engaged in leadership in educational institutions and outside of them and discusses implications for staff and faculty regarding how to support and engage these students and their leadership. © 2017 Wiley Periodicals, Inc., A Wiley Company.

Solomon Islands Botany

NARCIS (Netherlands)

Steenis, van C.G.G.J.

1969-01-01

A discussion of the Results of the Royal Society Expedition to the British Solomon Islands Protectorate, 1965. Organized by E.J.H. Corner. Phil. Trans. R. Soc. B 255 (1969) 185-631, 196 fig. University Printing House, Shaftesbury Road, Cambridge. Obtainable through booksellers or direct to the Royal

Biotransformation of trans-1-chloro-3,3,3-trifluoropropene (trans-HCFO-1233zd)

International Nuclear Information System (INIS)

Schmidt, Tobias; Bertermann, Rüdiger; Rusch, George M.; Tveit, Ann; Dekant, Wolfgang

2013-01-01

trans-1-Chloro-3,3,3-trifluoropropene (trans-HCFO-1233zd) is a novel foam blowing and precision cleaning agent with a very low impact for global warming and ozone depletion. trans-HCFO-1233zd also has a low potential for toxicity in rodents and is negative in genotoxicity testing. The biotransformation of trans-HCFO-1233zd and kinetics of metabolite excretion with urine were assessed in vitro and in animals after inhalation exposures. For in vitro characterization, liver microsomes from rats, rabbits and humans were incubated with trans-HCFO-1233zd. Male Sprague Dawley rats and female New Zealand White rabbits were exposed to 2,000, 5,000 and 10,000 ppm for 6 h and urine was collected for 48 h after the end of the exposure. Study specimens were analyzed for metabolites using 19 F NMR, LC-MS/MS and GC/MS. S-(3,3,3-trifluoro-trans-propenyl)-glutathione was identified as predominant metabolite of trans-HCFO-1233zd in all microsomal incubation experiments in the presence of glutathione. Products of the oxidative biotransformation of trans-HCFO-1233zd were only minor metabolites when glutathione was present. In rats, both 3,3,3-trifluorolactic acid and N-acetyl-(3,3,3-trifluoro-trans-propenyl)-L-cysteine were observed as major urinary metabolites. 3,3,3-Trifluorolactic acid was not detected in the urine of rabbits. Quantitation showed rapid excretion of both metabolites in both species (t 1/2 1/2 < 6 h). ► Glutathione adduct as predominant in vitro metabolite in all tested species. ► Toxic metabolites could not be detected in any great extent

Biotransformation of trans-1-chloro-3,3,3-trifluoropropene (trans-HCFO-1233zd)

Energy Technology Data Exchange (ETDEWEB)

Schmidt, Tobias [Institut für Toxikologie, Universität Würzburg, Versbacher Str. 9, 97078 Würzburg (Germany); Bertermann, Rüdiger [Institut für Anorganische Chemie, Universität Würzburg, Am Hubland, 97074 Würzburg (Germany); Rusch, George M.; Tveit, Ann [Honeywell, P.O. Box 1057, Morristown, NJ 07962-1057 (United States); Dekant, Wolfgang, E-mail: dekant@toxi.uni-wuerzburg.de [Institut für Toxikologie, Universität Würzburg, Versbacher Str. 9, 97078 Würzburg (Germany)

2013-05-01

trans-1-Chloro-3,3,3-trifluoropropene (trans-HCFO-1233zd) is a novel foam blowing and precision cleaning agent with a very low impact for global warming and ozone depletion. trans-HCFO-1233zd also has a low potential for toxicity in rodents and is negative in genotoxicity testing. The biotransformation of trans-HCFO-1233zd and kinetics of metabolite excretion with urine were assessed in vitro and in animals after inhalation exposures. For in vitro characterization, liver microsomes from rats, rabbits and humans were incubated with trans-HCFO-1233zd. Male Sprague Dawley rats and female New Zealand White rabbits were exposed to 2,000, 5,000 and 10,000 ppm for 6 h and urine was collected for 48 h after the end of the exposure. Study specimens were analyzed for metabolites using {sup 19}F NMR, LC-MS/MS and GC/MS. S-(3,3,3-trifluoro-trans-propenyl)-glutathione was identified as predominant metabolite of trans-HCFO-1233zd in all microsomal incubation experiments in the presence of glutathione. Products of the oxidative biotransformation of trans-HCFO-1233zd were only minor metabolites when glutathione was present. In rats, both 3,3,3-trifluorolactic acid and N-acetyl-(3,3,3-trifluoro-trans-propenyl)-L-cysteine were observed as major urinary metabolites. 3,3,3-Trifluorolactic acid was not detected in the urine of rabbits. Quantitation showed rapid excretion of both metabolites in both species (t{sub 1/2} < 6 h) and the extent of biotransformation of trans-HCFO-1233zd was determined as approximately 0.01% of received dose in rabbits and approximately 0.002% in rats. trans-HCFO-1233zd undergoes both oxidative biotransformation and glutathione conjugation at very low rates. The low extent of biotransformation and the rapid excretion of metabolites formed are consistent with the very low potential for toxicity of trans-HCFO-1233zd in mammals. - Highlights: ► No lethality and clinical signs were observed. ► Glutathione S-transferase and cytochrome P-450 dependent

Powdered activated carbon adsorption of two fishy odorants in water: Trans,trans-2,4-heptadienal and trans,trans-2,4-decadienal.

Science.gov (United States)

Li, Xin; Wang, Jun; Zhang, Xiaojian; Chen, Chao

2015-06-01

Powdered activated carbon (PAC) adsorption of two fishy odorants, trans,trans-2,4-heptadienal (HDE) and trans,trans-2,4-decadienal (DDE), was investigated. Both the pseudo first-order and the pseudo second-order kinetic models well described the kinetics curves, and DDE was more readily removed by PAC. In isotherm tests, both Freundlich and Modified Freundlich isotherms fitted the experimental data well. PAC exhibited a higher adsorption capacity for DDE than for HDE, which could be ascribed to the difference in their hydrophobicity. The calculated thermodynamic parameters (ΔG0, ΔH0, and ΔS0) indicated an exothermic and spontaneous adsorption process. PAC dosage, pH, and natural organic matter (NOM) presence were found to influence the adsorption process. With increasing PAC dosage, the pseudo first-order and pseudo second-order rate constants both increased. The value of pH had little influence on HDE or DDE molecules but altered the surface charge of PAC, and the maximum adsorption capacity occurred at pH9. The presence of NOM, especially the fraction with molecular weight less than 1k Dalton, hindered the adsorption. The study showed that preloaded NOM impaired the adsorption capacity of HDE or DDE more severely than simultaneously fed NOM did. Copyright © 2015. Published by Elsevier B.V.

Acute oral toxicity and anti-inflammatory activity of hydroalcoholic extract from Lampaya medicinalis Phil in rats

Directory of Open Access Journals (Sweden)

Glauco Morales

2014-01-01

Full Text Available BACKGROUND: Algesia and inflammation are related with several pathological conditions. It is known that many drugs available for the treatment of these problems cause unwanted side effects. This study was aimed at evaluating acute toxicity and anti-inflammatory activity of Lampaya medicinalis Phil. (Verbenaceae widely used in the folk medicine of Northern Chile against rheumatism, arthritis and body joints pain. RESULTS: Oral administration of hydroalcoholic extract (HAE at the highest dose of 3000 mg/ Kg body weight resulted in no mortalities or evidence of significant behavioral changes. Histological examination revealed normal architecture and no significant adverse effects were observed on the liver, kidney, heart, lung or ovaries and testicles. The results suggest that the oral administration of hydroalcoholic extract (HAE from Lampaya medicinalis did not produce any toxic effect in rats. Hydroalcoholic extract (HAE significantly inhibited the carrageenan-induced rat paw edema in dose - response relationship, at test doses of 37.5, 75, 150 and 300 mg/Kg body weight. Maximum inhibition (61.98 ± 2.69% was noted at 300 mg/Kg after 2 h of drug treatment carrageenan induced paw edema, whereas indomethacin produced 47.90 ± 1.16% of inhibition. The inhibitory values of edema at 3 h postcarrageenan were 31.04±0.75%, 40.51 ± 2.36%, 48.97 ± 1.14% and 56.87 ± 0.41% for 37.5, 75, 150, and 300 mg/kg of extract respectively. Indomethacin (10 mg/Kg gave a percentage inhibition of 49.44 ± 1.44. HAE (300 and 150 mg/kg induced an anti-inflammatory effect greater than (or comparable with the effect of indomethacin from 2nd to 4th hours of the experiment. CONCLUSIONS: Our results reveal for first time that compounds contained in the hydroalcoholic extract ofLampaya medicinalis Phil exert anti-inflammatory effect and the oral administration is safe and non toxic up to dose level 3000 mg/kg body weight. The anti

Survey of the trans-resveratrol and trans-piceid content of cocoa-containing and chocolate products.

Science.gov (United States)

Hurst, W Jeffrey; Glinski, Jan A; Miller, Kenneth B; Apgar, Joan; Davey, Matthew H; Stuart, David A

2008-09-24

Dietary resveratrol (3,4',5-trihydroxystilbene) has been implicated in the health benefits associated with grapes and red wine, more specifically with potential benefits for metabolic syndrome, energy use, and increased endurance. Levels of trans-resveratrol and its glucoside, trans-piceid, were determined in 19 top selling commercially available cocoa-containing and chocolate products from the U.S. market. Amounts of trans-resveratrol and trans-piceid were closely correlated with the amount of nonfat cocoa solids (NFCS) in the cocoa-containing products. Among these products, trans-resveratrol levels were highest in cocoa powders (1.85 +/- 0.43 microg/g), followed by unsweetened baking chocolates (1.24 +/- 0.22), semisweet chocolate baking chips (0.52 +/- 0.14), dark chocolates (0.35 +/- 0.08), milk chocolates (0.10 +/- 0.05), and chocolate syrups (0.09 +/- 0.02). These cocoa-containing and chocolate products have about 3-5 times more trans-piceid than trans-resveratrol. Levels of trans-piceid were highest in the cocoa powders (7.14 +/- 0.80 microg/g), followed by unsweetened baking chocolates (4.04 +/- 0.14), semisweet chocolate baking chips (2.01 +/- 0.18), dark chocolates (1.82 +/- 0.36), milk chocolates (0.44 +/- 0.06), and chocolate syrups (0.35 +/- 0.06). On an equal weight basis, cocoa powder had about half as much trans-resveratrol as the average California red wine. On a per serving basis, cocoa-containing and chocolate products had less trans-resveratrol than red wine and grape juice but more than roasted peanuts. Overall, these cocoa-containing and chocolate products rank second after red wines and grape juice in foods with the highest levels of total trans-resveratrol in the diet.

Homologous SV40 RNA trans-splicing: Special case or prime example of viral RNA trans-splicing?

Directory of Open Access Journals (Sweden)

Sushmita Poddar

2014-06-01

Full Text Available To date the Simian Virus 40 (SV40 is the only proven example of a virus that recruits the mechanism of RNA trans-splicing to diversify its sequences and gene products. Thereby, two identical viral transcripts are efficiently joined by homologous trans-splicing triggering the formation of a highly transforming 100 kDa super T antigen. Sequences of other viruses including HIV-1 and the human adenovirus type 5 were reported to be involved in heterologous trans-splicing towards cellular or viral sequences but the meaning of these events remains unclear. We computationally and experimentally investigated molecular features associated with viral RNA trans-splicing and identified a common pattern: Viral RNA trans-splicing occurs between strong cryptic or regular viral splice sites and strong regular or cryptic splice sites of the trans-splice partner sequences. The majority of these splice sites are supported by exonic splice enhancers. Splice sites that could compete with the trans-splicing sites for cis-splice reactions are weaker or inexistent. Finally, all but one of the trans-splice reactions seem to be facilitated by one or more complementary binding domains of 11 to 16 nucleotides in length which, however occur with a statistical probability close to one for the given length of the involved sequences. The chimeric RNAs generated via heterologous viral RNA trans-splicing either did not lead to fusion proteins or led to proteins of unknown function. Our data suggest that distinct viral RNAs are highly susceptible to trans-splicing and that heterologous viral trans-splicing, unlike homologous SV40 trans-splicing, represents a chance event.

The role of strength anisotropy in the development of deep-seated gravitational slope deformation features in schist at Roys Peak, South Island, New Zealand

Science.gov (United States)

Brideau, M.

2013-12-01

This study looked at the interaction between the rock strength anisotropy and discontinuity orientations on the development of well-expressed deep-seated gravitational slope deformation (DSGSD) features around Roys Peak. The project area is located near the town of Wanaka in the Otago region of New Zealand's South Island. The Roys Peak area has well defined geomorphological features (antislope scarps and split ridges) typically associated with DSGSD over a distance extending almost 4.5 km along the Lake Wanaka Valley. The summit corresponds with the intersection of two prominent ridges running approximately north-south and east-west and has an elevation of 1580 metres above sea level with a local relief of 1250 m. The bedrock geology at Roys Peak consists of Late Paleozoic to Mid Mesozoic pelitic schist having a granitic protolith. The study area has been glaciated several times during the Quaternary Period. Glaciers have strongly influenced the landscape by rounding the spurs in the valley bottom and steepening the lower parts of mountains. Roys Peak is located approximately 75km south from the Alpine Fault (boundary between the Pacific and Australian plates) and as such the project area is not particularly seismically active with only 52 earthquakes with a magnitude greater than 4 within a 50km radius of the project area listed in the New Zealand Historical Earthquake Database. Engineering geological mapping at Roys Peak identified three discontinuity sets and a pervasive schistose fabric in a dip-slope position with the main valley orientation. The rock mass quality was described in the field using the Geological Strength Index (GSI). The observed rock mass quality at Roys Peak had a GSI range between 30-45. This corresponds to a blocky/disturbed/seamy structure with fair quality discontinuity surfaces. The intact rock strength of the schist rock was evaluated using field estimates, Schmidt hammer rebound values, and point load tests. The three methods overlap

Abordagem assistencial ao neonato portador de mielomeningocele segundo o modelo de adaptação de Roy Abordaje asistencial al neonato portador de mielomeningocele según el modelo de adaptación de Roy Care delivery to newborns with myelomeningocele according to Roy's adaptation model

Directory of Open Access Journals (Sweden)

Eloah de Paula Pessoa Gurgel

2010-09-01

Full Text Available O objetivo deste estudo de caso foi identificar os diagnósticos de Enfermagem de um bebê portador de mielomeningocele, internado na Unidade de Terapia Intensiva Neonatal (UTIN, abordando os aspectos fisiológicos segundo a Teoria de Adaptação de Roy, e elaborar ações de enfermagem pertinentes a estes aspectos. O estudo foi desenvolvido na UTIN da Maternidade Escola Assis Chateaubriand, na cidade de Fortaleza, Ceará, Brasil, nos meses de dezembro de 2007 a março de 2008, quando foi utilizado um roteiro de levantamento de dados. Na análise, reconheceram-se os diagnósticos: padrão respiratório ineficaz; nutrição desequilibrada: menos do que as necessidades corporais; integridade da pele prejudicada; risco para infecção e percepção sensorial perturbada. A utilização desta teoria permitiu reconhecer que o RN pode desencadear respostas positivas ou negativas mediante estímulos, e que as metas e intervenções implementadas foram importantes para a substituição de respostas ineficazes por respostas adaptativas.El objetivo de este estudio de caso fue identificar los diagnósticos de Enfermería, abordando los aspectos fisiológicos según la Teoría de Adaptación de Roy, de un bebé portador de mielomeningocele, internado en la Unidad de Terapia Intensiva Neonatal (UTIN, y elaborar acciones de enfermería pertinentes a tales aspectos. El estudio fue desarrollado en al UTIN de la Maternidad Escuela Assis Chateubriand, en la ciudad de Fortaleza-Ceará-Brasil, en los mese de diciembre de 2007 a marzo de 2008, momento en el cual fue utilizado un cuestionario para la colecta de datos. En el análisis, se reconocieron los diagnósticos: patrón diagnóstico ineficaz, nutrición desequilibrada (inferior a las necesidades corporales, integridad de la piel afectada, riesgo de infección y percepción sensorial perturbada. La utilización de esta teoría permitió reconocer que el RN puede desencadenar respuestas positivas o negativas a

Arundhati Roy, a One-woman Dissident Force against the Instant-Mix Imperial Democracy Arundhati Roy, la force d’une seule femme face à la démocratie impériale prête à l’emploi

Directory of Open Access Journals (Sweden)

Geetha Ganapathy-Doré

2009-10-01

Full Text Available Mieux connu pour son roman Le Dieu des petits riens qui a ébloui le monde anglophone par son style novateur et choqué les lecteurs indiens en mettant en scène l’amour entre une femme de haute caste et un paria, Arundhati Roy est une écrivaine engagée qui dénonce les dérives pronucléaires et néolibérales du gouvernement indien et mène une lutte contre la mondialisation capitaliste là où elle se manifeste. Les essais polémiques que Roy a écrits après les attentats du 11 septembre s’attaquent de façon virulente à l’impérialisme américain. Elle déconstruit l’Empire en exposant les piliers invisibles de son architecture et en décodant sa rhétorique. Elle en analyse les  présupposés éthiques, les rouages économiques, la pénétration culturelle et les implications juridiques afin de définir les stratégies de résistance pour réaffirmer les valeurs de la dignité humaine, de la justice sociale et de la paix. Dans le projet d’assiéger l’Empire, elle est appuyée par des dissidents célèbres tels que Noam Chomsky, Howard Zinn, Amy Goodman et d’autres.

Roy Ellen, Stephen J. Lycett, Sarah E. Johns, eds., 2013, Understanding Cultural Transmission in Anthropology: A Critical Synthesis New York and Oxford: Berghahn Books

Directory of Open Access Journals (Sweden)

Clelia Viecelli

2015-10-01

Full Text Available recensione: Roy Ellen, Stephen J. Lycett, Sarah E. Johns, eds., 2013, Understanding Cultural Transmission in Anthropology: A Critical Synthesis New York and Oxford: Berghahn Books di Clelia Viecelli

"There's no chasing involved": cis/trans relationships, "tranny chasers," and the future of a sex-positive trans politics.

Science.gov (United States)

Tompkins, Avery Brooks

2014-01-01

This article adds to a small, but growing, body of work on trans sexualities and partnerships, and provides a much-needed inquiry into the complex and contested politics of desire when we take trans identities, bodies, and sexualities into account. Using digital ethnographic data from YouTube videos along with in-person observational data from LGBTQ and trans conferences in the U.S., Tompkins argues that a sex-positive trans politics cannot emerge in trans and trans-allied communities if the rhetoric of the "tranny chaser" continues to inform discourses of desire and attraction to trans people.

Obituary: Roy Henry Garstang (1925-2009)

Science.gov (United States)

Malville, J.

2011-12-01

Roy Henry Garstang 84 passed away on November 1, 2009 in Boulder Colorado. He was born in Southport, England in September of 1925 to Percy Brocklehurst and Eunice (Gledhill) Garstang. He won a scholarship to Caius College in Cambridge University. Because it was wartime, he could spend only two years at his studies. However, he managed to complete three years of required work during that time, and then spent 1945-46 as a Junior Scientific Officer at the Royal Aircraft Establishment at Farnborough. He received his BA in 1946 from Cambridge, his MA in 1950, and his PhD in Mathematics in 1954, with a thesis: "Atomic Transitions in Astrophysics," working under D. R. Hartree. He also received a ScD from Cambridge in Physics and Chemistry in 1983. He married Ann in August 1959. She and two daughters, Jennifer and Susan, survive him. While still pursuing his PhD, Roy Garstang served as a Research Associate at the Yerkes Observatory, from 1951-1952, working under Subrahmanyan Chandrasekhar. During that time he continued with his own calculations of atomic structure and transition probabilities, although these were not part of Chandra's research interests. After earning his PhD, he went to teach at the University of London, where he also served as the Assistant Director of the University of London Observatory (1959-1964). He was editor of "The Observatory" Magazine form 1953-1960. The continuing theme of this research was to help meet the needs of astrophysicists for atomic data. In 1964, he left England for the United States, where he joined the faculty at the University of Colorado, Boulder, where he would remain for the rest of his professional career. It was entirely fitting, considering his interest in performing calculations of interest to astrophysicists, that soon after arriving in Boulder he was appointed Chairman of JILA - Joint Institute for Laboratory Astrophysics (1966-1967). He was Director of the Division of Physics and AstroGeophysics (1979-80), acting

TransAlta: More than a utility

International Nuclear Information System (INIS)

Mikalson, D.A.

1991-01-01

TransAlta Utilities Corporation is Canada's largest privately owned utility and is also a major coal mining company. In 1989, TransAlta produced 20.9% of all coal mined in Canada. A brief history of TransAlta is presented along with TransAlta's present coal operations and plans for the next three years. An overview is presented of how TransAlta Fuel Supply is organized to utilize contracted mining operation, engineering and environmental services and in-house capabilities. Recent strategic initiatives to improve organizational efficiency and the mining operations are discussed. These range from developing a common departmental vision to modifying major mining equipment. TransAlta's proactive role in clean coal combustion such as low NOx-SOx burner, integrated combined cycle gasification, and other energy research projects is reviewed. A summary is provided of recent participation of TransAlta in environmental management initiatives. Recent successes of TransAlta's unregulated subsidiary in the development of cogeneration facilities and the future of this area of business are discussed. 8 refs., 4 figs

Facts about trans fats

Science.gov (United States)

Trans fat is a type of dietary fat . Of all the fats, trans fat is the worst for your health. Too much ... from solid margarine to soft margarine. Ask what type of fats foods are cooked in when you eat out ...

Exploración estocástica de las superficies de energía potencial de dímeros cis-trans y trans-trans del ácido fórmico

Directory of Open Access Journals (Sweden)

Said F. Figueredo

2014-01-01

Full Text Available Potential energy surface (PES of cis-trans and trans-trans formic acid dimers were sampled using a stochastic method, and the geometries, energies, and vibrational frequencies were computed at B3LYP/6-311++G(3df,2p level of theory. The results show that molar free energy of dimerization deviated up to 108.4% when basis set superposition error (BSSE and zero-point energy (ZPE were not considered. For cis-trans dimers, C=O and O - H bond weakened, whereas C - O bonds strengthened due to dimerization. Also, trans-trans FA dimers did not show a trend regarding strengthening or weakening of the C=O, O - H and C - O bonds.

Contraste de un modelo de envejecimiento exitoso derivado del modelo de Roy

Directory of Open Access Journals (Sweden)

María Amparo Kantún Marín

2017-01-01

Full Text Available Se formula y contrasta un modelo de envejecimiento exitoso derivado del modelo de adaptación de Roy. Se analizó una muestra no probabilística de 255 adultos mayores de seis centros sociales y un centro médico de consulta externa en Nuevo León, México. Se usó un modelamiento de ecuaciones estructurales. En el modelo final los estímulos focales de autopercepción del envejecimiento, entorno peatonal inmediato y el estímulo contextual de síntomas depresivos incidieron sobre el afrontamiento, que a su vez predijo el envejecimiento exitoso. El modelo tuvo buen ajuste al añadirse dos correlaciones entre residuos de medida de afrontamiento y envejecimiento exitoso. Los resultados obtenidos sugieren que el afrontamiento es un indicador directo del envejecimiento activo.

Cis By Trans

OpenAIRE

Rodovalho,Amara Moira

2017-01-01

Cis, trans: above all, metaphors. Cisjordan, region skirting the Jordan River. Cisplatin, Uruguay’s ancient name, region occupying one of the banks of the Prata River. Trans- Amazonian, that which crosses the Amazon; transatlantic, that which crosses the Atlantic. Cisalpine, transalpine. The geometric isomerism of Organic Chemistry, where “cis” are atoms that, when molecules are divided in half, remain on the same side, and “trans” those remaining on opposite sides. Ev...

Crystallinity and the effect of ionizing radiation in polyethylene. V. Distribution of trans-vinylene and trans, trans conjugated double bonds in linear polyethylene

International Nuclear Information System (INIS)

Patel, G.N.

1975-01-01

Freeze-dried chain folded single crystals and the single crystals without amorphous surface layers (crystalline cores) of different thicknesses of linear polyethylene were irradiated with 60 Co γ-rays up to 600 Mrad. Concentration of trans-vinylene double bonds and conjugated diene produced during irradiation of the crystals was measured by infrared. Concentrations of trans-vinylene and of the conjugated diene were independent of thickness of crystalline core which suggest that the double bonds were randomly distributed in the crystalline parts of the crystals. Concentrations of trans-vinylene and of conjugated double bonds were lower in chain-folded crystals than in the crystalline cores and this suggests that the folds (amorphous surface layers) are less preferential sites for formation of the double bonds. The zero-order growth and first-order decay kinetics of trans-vinylene double bonds was studied by the equation derived by Dole et al. The equation is strictly obeyed up to 300 Mrad and the results then deviate. Since there is the decay of trans-vinylene double bonds and though there are no crosslinks in the crystalline cores, it has been suggested that the decay of the double bond does not result in the crosslinks

PUTAS Y TRANS. ¿ESTÁN LAS MUJERES TRANS EN LAS NARRATIVAS SOBRE LA PROSTITUCIÓN?

Directory of Open Access Journals (Sweden)

Liza García Reyes

2015-06-01

Full Text Available Este artículo evidencia los principales resultados de la investigación cualitativa titulada: Putas y trans. Narrativas sobre mujeres trans en España –desarrollada en 2010–, la cual estudió su presencia en textos académicos sobre prostitución en España, producidos entre los años 2000-2009. El análisis de contenido de 34 narrativas evidenció que las referencias a mujeres trans resulta escasa en ellas, aun siendo ellas quienes tienen mayor presencia en la prostitución, en proporción con las mujeres biológicas. Solo nueve textos mencionan la experiencia trans al interior de la prostitución y, entre estos, el asunto solo aparece asertivamente descrito cuando son las propias mujeres trans quienes escriben. AbstractThis paper shows the results of a qualitative research entitled: Hookers and Trans Women: Narratives about trans women in Spain. This study was developed in 2010 and it is based on presence of trans women in the academic texts of prostitution in Spain produced between 2000 and 2009. The content analysis of thirty four narratives showed that the references to in transsexual women in these texts were few, although they have more presence into prostitution, in relation to the biological women. Only nine texts show an experience of prostitution and among these, transexperience only is described assertively when transsexual women write the texts themselves.

Radical feminists & trans activists truce

OpenAIRE

Mackay, F.

2014-01-01

#GenderWeek: Truce! When radical feminists and trans feminists empathise\\ud Feminist Times\\ud By Finn Mackay \\ud read all #GenderWeek articles.\\ud We wanted to explore the ground between the polarised, entrenched positions in the so-called “TERF-war”. Radical feminists on one pole, trans-inclusionary feminists and trans activists on the other. The disputed territory being women-only space, language and the ever changing legal framework surrounding gender.\\ud Entrenchment leads to stalemate. S...

Trans advanced surface laser ablation (TransPRK) outcomes using SmartPulseTechnology.

Science.gov (United States)

Aslanides, Ioannis M; Kymionis, George D

2017-02-01

To evaluate early visual rehabilitation, post-operative pain, epithelial healing and haze after transepithelial photorefractive keratectomy (TransPRK) using the SmartPulseTechnology (SPT) of Schwind Amaris (Schwind eye-tech-solutions GmbH, Kleinostheim, Germany). This was a retrospective comparative evaluation of a cohort of myopic patients undergoing TransPRK with SPT (group 1), with one matched control group that underwent conventional TransPRK (group 2). All cases had a 6-month post-operative follow-up including visual acuity and slit-lamp examination. Subjective evaluation of pain was recorded post-operatively. 49 eyes of 25 patients in group 1 and 40 eyes of 20 patients in group 2 were enrolled. The patients' visual rehabilitation was significantly faster in group 1, one day and one week post-operatively (P0.05). TransPRK using SPT provides promising results in the early post-operative period. Visual rehabilitation, re-epithelialization and pain were faster in the early post-operative period in group 1 in comparison with group 2. Haze formation was not significantly different between the two groups; however, it was consistently less in group 1. Copyright © 2016 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.

Trans as Contested Intelligibility

DEFF Research Database (Denmark)

Raun, Tobias

2014-01-01

Denne artikel rejser en række epistemologiske og metodologiske spørgsmål vedrørende læsningen af trans som identitetskategori. Disse spørgsmål er stærkt underbelyste i en skandinavisk akademisk kontekst, om end der el- lers i stigende grad produceres analyser af trans identitetsnarrativer. Artikl...

The Danish trans-fatty acids ban

DEFF Research Database (Denmark)

Vallgårda, Signild

2017-01-01

In 2003 an executive order was issued banning industrially produced trans-fatty acids above a low level in food items in Denmark. To date, only a few other countries have followed Denmark’s example. The way health consequences of trans fats were translated by the different actors enabled the crea......In 2003 an executive order was issued banning industrially produced trans-fatty acids above a low level in food items in Denmark. To date, only a few other countries have followed Denmark’s example. The way health consequences of trans fats were translated by the different actors enabled...

TransForm: TransAlta 2000 annual report

International Nuclear Information System (INIS)

2001-01-01

Financial information from TransAlta Corp. was presented along with a review of their operations throughout 2000 and a summary of the how the electric utility is doing in terms of power generation, independent power producers, transmission and energy marketing. The utility has changed from a regulated vertically integrated utility into one of Canada's largest non-regulated electric power generators. The utility sold its retail businesses in Alberta and New Zealand and now focuses on coal and hydro generation, gas generation, high-voltage transmission and energy marketing. The newly constructed Centralia, Washington generation facility was brought on line with 1,340 MW in May 2000, on time and on budget. This was the platform to diversify their generation into the United States. The utility reported a solid financial year with $177.9 million in earnings from continuing operations, an 83 per cent increase from 1999, driven mostly by the results of Centralia and power marketing and trading businesses. A financial loss was suffered when the Wabamum power plant in Alberta was shut down for several months to repair a boiler. The utility made excellent progress toward their goal of 15,000 megawatts by 2005 by starting with the construction of what will be one of Canada's largest cogeneration facilities at Sarnia, Ontario. TransAlta also commissioned a 360 MW cogeneration facility at Poplar Creek at Suncor's Fort McMurray oil sand facility. TransAlta also has an excellent track record in developing power generation projects internationally. refs., tabs., figs

High-Precision Determination of the Pion-Nucleon σ Term from Roy-Steiner Equations

Science.gov (United States)

Hoferichter, Martin; Ruiz de Elvira, Jacobo; Kubis, Bastian; Meißner, Ulf-G.

2015-08-01

We present a determination of the pion-nucleon (π N ) σ term σπ N based on the Cheng-Dashen low-energy theorem (LET), taking advantage of the recent high-precision data from pionic atoms to pin down the π N scattering lengths as well as of constraints from analyticity, unitarity, and crossing symmetry in the form of Roy-Steiner equations to perform the extrapolation to the Cheng-Dashen point in a reliable manner. With isospin-violating corrections included both in the scattering lengths and the LET, we obtain σπ N=(59.1 ±1.9 ±3.0 ) MeV =(59.1 ±3.5 ) MeV , where the first error refers to uncertainties in the π N amplitude and the second to the LET. Consequences for the scalar nucleon couplings relevant for the direct detection of dark matter are discussed.

TransCanada PipeLines Limited 1998 annual report : TransCanada energy solutions

International Nuclear Information System (INIS)

1999-01-01

Financial information from TransCanada PipeLines Limited and a review of the company's 1998 operations was made available for the benefit of shareholders. TransCanada's pipeline system transports natural gas and crude oil from Western Canada Sedimentary Basin to North America's major energy markets. Net earnings from continuing operations for 1998, before unusual charges, were $575 million ($ 355 million after unusual charges) compared to $522 million for 1997. Solid performances from the energy transmission and international business, when compared to 1997, were more than offset by a decreased contribution from energy processing. TransCanada recorded integration costs of $166 million, after tax, related to the merger with NOVA in 1998, which was the major operational accomplishment during the year, creating a seamless economic energy delivery, processing and marketing system from the wellhead to the market. tabs., figs

Comparative evaluation of capillary electrophoresis and high-performance liquid chromatography for the separation of cis-cis, cis-trans, and trans-trans isomers of atracurium besylate.

Science.gov (United States)

de Moraes, M de L; Polakiewicz, B; Mattua, M F; Tavares, M F

1998-01-01

Atracurium besylate is a highly selective nondepolarizing neuromuscular blocking agent routinely used during anesthetic procedures. The commercial presentation of this drug is a mixture of positional isomers, cis-cis, cis-trans, and trans-trans. Reversed-phase high-performance liquid chromatography has been the technique of choice for the analysis of atracurium besylate formulations at the quality control laboratory of Núcleo de Desenvolvimento Cristália (São Paulo, Brazil), a local pharmaceutical company. HPLC analysis is usually conducted under gradient elution using acetonitrile/0.1 M phosphate buffer eluent mixture as mobile phase and an octadecyl silica (ODS)-packed column. The complete elution of the three isomers takes about 1 hr. In this work, an alternative capillary electrophoresis methodology was developed. The complete resolution of all three isomers was accomplished in about 13 min (+20 kV/72 cm, 211 nm direct detection) using a 60-mM phosphate buffer solution (pH 4) containing 20 mM beta-cyclodextrin and 4 M urea. The isomer ratio was found to be 59.1% cis-cis, 35.9% cis-trans, and 5.02% trans-trans (expected ratio: 59:35:6). Laudanosine, a major metabolite of atracurium besylate, was identified in two commercially available formulations, Tracur (Núcleo de Desenvolvimento Cristália) and Tracrium (Glaxo Wellcome, S.A., Rio de Janeiro, Brazil). Its concentration increases considerably during storage of the product, even if the product is stored at low temperatures.

Afrontamientos de enfermeras al asumir la gerencia escolar: una mirada desde la teoría de Roy O afrontamento das enfermeiras ao assumirem a gerência escolar: um olhar a partir da teoria de Roy Confrontation of nurses when assuming the school management: a look from Roy's adaptation theory

Directory of Open Access Journals (Sweden)

Mariana Olizbeth Salinas Alvirde

2012-06-01

Full Text Available Esta investigación aborda la transición gerencial de las instituciones educativas de médicos a enfermeras con objetivo de delimitar mecanismos de afrontamiento y modos adaptativos al iniciar la gestión en el entorno académico. Se realizó estudio cualitativo de corte histórico-social sustentado por la teoría de adaptación de Roy. Los sujetos estudiados fueron las primeras profesoras que ocuparon la dirección de escuelas universitarias de enfermería, a través de entrevistas se recolectaron los datos. Los resultados revelaron que la incursión de enfermeras permitió abordar el proceso salud-enfermedad de manera distinta al acto médico, lo que significó generar mecanismos de afrontamiento para trabajar en la construcción de paradigmas que conformarán un pensamiento profesional y visión disciplinaria propia, a través de un plan de estudio solido. Concluímos que se renovaron los métodos de trabajo, creándose nuevos niveles académicos, especializaciones y titularidades en las materias en base a sacrificio y dedicación, iniciándose su autonomía profesional.Esta pesquisa aborda a transição gerencial das instituiçðes educativas de médicos às enfermeiras, com o objetivo de delimitar mecanismos de afrontamento e modos adaptativos ao iniciar a gestão no âmbito acadêmico. Realizou-se um estudo qualitativo de abordagem histórico-social, orientado pela teoria de adaptação de Roy. Os sujeitos estudados foram as primeiras professoras que ocuparam a direção das escolas universitárias de enfermagem; os dados foram recoletados por meio de entrevistas. Os resultados revelaram que a incursão de enfermeiras permitiu abordar o processo saúde-doença de maneira distinta ao ato médico, o que significou gerar mecanismos de afrontamento para trabalhar na construção de paradigmas que conformarão um pensamento profissional e uma visão disciplinar própria, a partir de um plano de estudo sólido. Concluiu-se que se renovarão os

Assistência de enfermagem a portadores de anemia falciforme, à luz do referencial de Roy Atención de enfermería a portadores de anemia falciforme apoyada en el modelo conceptual de Roy Nursing care to patiens with sickle cell disease in the light of Roy's model

Directory of Open Access Journals (Sweden)

Maria Lúcia Ivo

2003-03-01

Full Text Available O presente estudo busca aplicar os conceitos do modelo de Adaptação de Roy para identificar os comportamentos (adaptativos e inefetivos de pacientes portadores de anemia falciforme, bem como os estímulos focais, contextuais e residuais responsáveis por tais comportamentos. A coleta de dados foi realizada no Ambulatório de Hemoglobinopatias do HCFMRP-USP. Foram sujeitos 9 pacientes (8 mulheres e 1 homem. Evidenciou-se, no modo fisiológico, o comportamento inefetivo de baixa oxigenação e suas conseqüências (desenvolvimento físico comprometido, retardo sexual, icterícia por hemólise, alterações respiratórias. No modo psicossocial, o autoconceito teve a diminuição da auto-estima como o comportamento mais destacado; o desempenho de papel foi caracterizado por mudanças de ocupação; quanto à interdependência, a mãe foi referida como o outro significante mais freqüente. Identificou-se, predominantemente, como estímulo causador dos comportamentos inefetivos, a vaso-oclusão. Verificou-se que a função fisiológica afetada altera os outros modos adaptativos.Este estudio busca aplicar los conceptos del modelo de adaptación de Roy para identificar los comportamientos (adaptativos e inefectivos de pacientes portadores de anemia falciforme, así como también como los estímulos focales, contextuales y residuales responsables por estos comportamientos. La recolección de datos fue realizada en la consulta externa de Hemoglobinopatias del HCFMRP-USP. Fueron sujetos 9 pacientes (8 mujeres y 1 hombre. Los resultados evidenciaron, en el modo fisiológico, el comportamiento inefectivo de baja oxigenación y sus consecuencias (desarrollo físico comprometido, retardo sexual, ictericia por hemólisis, alteraciones respiratorias. En el modo psicosocial y considerando el autoconcepto, fue observada la disminución de la auto estima como el comportamiento más destacado; el desempeño del rol fue caracterizado por cambios de ocupaci

Introduction. Progress in astronomy: from gravitational waves to space weather.

Science.gov (United States)

Thompson, J Michael T

2008-12-13

This brief paper introduces and reviews the 'visions of the future' articles prepared by leading young scientists throughout the world for the first of two Christmas 2008 Triennial issues of Phil. Trans. R. Soc. A, devoted, respectively, to astronomy and Earth science. Contributions in astronomy include the very topical gamma-ray bursts, new ideas on stellar collapse and the unusual atmospheres of synchronized planets orbiting nearby stars.

Trans Ova Genetics, L.C.

Science.gov (United States)

The EPA is providing notice of a proposed Administrative Penalty Assessment against Trans Ova Genetics, L.C., a business located at 2938 380th Street Sioux Center, IA 51250, for alleged violations at the Trans Ova Genetics, L.C.’s facility located in 12425

The K*0(800) scalar resonance from Roy-Steiner representations of πK scattering

International Nuclear Information System (INIS)

Descotes-Genon, S.; Moussallam, B.

2006-01-01

We discuss the existence of the light scalar meson K * 0 (800) (also called κ) in a rigorous way, by showing the presence of a pole in the πK→πK amplitude on the second Riemann sheet. For this purpose, we study the domain of validity of two classes of Roy-Steiner representations in the complex energy plane. We prove that one of them is valid in a region sufficiently broad in the imaginary direction. From this representation, we compute the l=0 partial wave in the complex plane neither making any additional approximation nor having model dependence, relying only on experimental data. A scalar resonance with strangeness S=1 is found with the following mass and width: M κ =658±13 MeV and Γ κ =557±24 MeV. (orig.)

Spectroscopic and density functional theory studies of trans-3-(trans-4-imidazolyl)acrylic acid.

Science.gov (United States)

Arjunan, V; Remya, P; Sathish, U; Rani, T; Mohan, S

2014-08-14

The structural parameters, thermodynamic properties and vibrational frequencies of the optimised geometry of trans-3-(trans-4-imidazolyl)acrylic acid have been determined from B3LYP methods with 6-311++G(**) and cc-pVTZ basis sets. The effects of substituents (acrylyl group) on the imidazole vibrational frequencies are analysed. The vibrational frequencies of the fundamental modes of trans-3-(trans-4-imidazolyl)acrylic acid have been precisely assigned and analysed and the theoretical results are compared with the experimental vibrations. (1)H and (13)C NMR isotropic chemical shifts are calculated and the assignments made are compared with the experimental values. The energies of important MO's of the compound are also determined from DFT method. The total electron density and electrostatic potential of the compound are determined by natural bond orbital analysis. Various reactivity and selectivity descriptors such as chemical hardness, chemical potential, softness, electrophilicity, nucleophilicity and the appropriate local quantities employing natural population analysis (NPA) are calculated. Copyright © 2014 Elsevier B.V. All rights reserved.

A new analysis of π K scattering from Roy and Steiner type equations

International Nuclear Information System (INIS)

Buettiker, P.; Descotes-Genon, S.; Moussallam, B.

2004-01-01

With the aim of generating new constraints on the OZI suppressed couplings of chiral perturbation theory a set of six equations of the Roy and Steiner type for the S- and P-waves of the πK scattering amplitudes is derived. The range of validity and the multiplicity of the solutions are discussed. Precise numerical solutions are obtained in the range E or sim 1 GeV for both πK→πK and ππ→ KK amplitudes. Our main result is the determination of a narrow allowed region for the two S-wave scattering lengths. Present experimental data below 1 GeV are found to be in generally poor agreement with our results. A set of threshold expansion parameters, as well as sub-threshold parameters are computed. For the latter, a matching with the SU(3) chiral expansion at NLO is performed. (orig.)

Epoxidation of the methamphetamine pyrolysis product, trans-phenylpropene, to trans-phenylpropylene oxide by CYP enzymes and stereoselective glutathione adduct formation

International Nuclear Information System (INIS)

Sanga, Madhu; Younis, Islam R.; Tirumalai, Padma S.; Bland, Tina M.; Banaszewska, Monica; Konat, Gregory W.; Tracy, Timothy S.; Gannett, Peter M.; Callery, Patrick S.

2006-01-01

Pyrolytic products of smoked methamphetamine hydrochloride are well established. Among the various degradation products formed, trans-phenylpropene (trans-β-methylstyrene) is structurally similar to styrene analogues known to be bioactivated by CYP enzymes. In human liver microsomes, trans-phenylpropene was converted to the epoxide trans-phenylpropylene oxide (trans-2-methyl-3-phenyloxirane) and cinnamyl alcohol. Incubation of trans-phenylpropene with microsomes in the presence of enzyme-specific P450 enzyme inhibitors indicated the involvement of CYP2E1, CYP1A2, and CYP3A4 enzymes. Both (R,R)-phenylpropylene oxide and (S,S)-phenylpropylene oxide were formed in human liver microsomal preparations. Enantiomers of trans-phenylpropylene oxide were stereoselectively and regioselectively conjugated in a Phase II drug metabolism reaction catalyzed by human liver cytosolic enzymes consisting of conjugation with glutathione. The structure of the phenylpropylene oxide-glutathione adduct is consistent with nucleophilic ring-opening by attack at the benzylic carbon. Exposure of cultured C6 glial cells to (S,S)-phenylpropylene oxide produced a cytotoxic response in a concentration-dependent manner based on cell degeneration and death

A comparison of trans-cranial and trans-sphenoidal approaches for vision improvement due to pitutary adenomas

Directory of Open Access Journals (Sweden)

Fakhr Tabatabai SA

1997-07-01

Full Text Available To improve visual disturbance, optic nerve decompression can be performed via transcranial or tran-sphenoidal approaches. Although the surgical exposure in transcranial approach is favourable, yet the optic nerve's presence in the field may make it vulnerable to damage. Of fighty patients with different types of pituitary adenomas, 35 cases with medium-sized (1-3 cm tumors have been studied in a randomized clinical trial during a three year period, to compare the applicability of these approaches. While short hospital stay with better visual outcome was observed in fifteen trans-sphenoidal cases, in comparison to 20 trans-cranial cases, however the preoperative visual status and underlying disorders were similar in both groups. Decompressing the optic apparatus, trans-sphenoidally, seems beneficial, where there are no contraindications for the procedure in medium-sized pituitary adenomas

Reasons for decision in the matter of Trans Mountain Pipeline Inc. (formerly Terasen Pipelines (Trans Mountain) Inc.) : tariffs

International Nuclear Information System (INIS)

2007-01-01

In 2006 and 2007 Terasen Pipelines (Trans Mountain) Inc. (now Trans Mountain Pipeline Inc.) submitted a series of applications to the National Energy Board for revisions to the Trans Mountain Tariffs. They were filed in response to apportionment concerns on the Trans Mountain pipeline. Four of the applications involved pronounced and contentious changes to the capacity allocation procedures on the pipeline system. For ease of reference, the Board amalgamated its 4 decisions on these applications into a single document. A map of the Trans Mountain pipeline system as a whole was presented along with a detailed map indicating the delivery locations served by the system in the lower mainland of British Columbia and the state of Washington. The issues considered by the Board in each of these decisions included capacity allocation for Westridge Dock; capacity allocations to export destinations; common carriage requirements; and the need for creating a new barge subcategory. Relevant sections of the National Energy Board Act referred to in the decisions were highlighted. This document also listed the Trans Mountain Tariffs that have introduced notable revisions to the capacity allocation procedures on the system since September 2003. 16 refs., 2 figs., 3 appendices

Cathode materials review

Science.gov (United States)

Daniel, Claus; Mohanty, Debasish; Li, Jianlin; Wood, David L.

2014-06-01

The electrochemical potential of cathode materials defines the positive side of the terminal voltage of a battery. Traditionally, cathode materials are the energy-limiting or voltage-limiting electrode. One of the first electrochemical batteries, the voltaic pile invented by Alessandro Volta in 1800 (Phil. Trans. Roy. Soc. 90, 403-431) had a copper-zinc galvanic element with a terminal voltage of 0.76 V. Since then, the research community has increased capacity and voltage for primary (nonrechargeable) batteries and round-trip efficiency for secondary (rechargeable) batteries. Successful secondary batteries have been the lead-acid with a lead oxide cathode and a terminal voltage of 2.1 V and later the NiCd with a nickel(III) oxide-hydroxide cathode and a 1.2 V terminal voltage. The relatively low voltage of those aqueous systems and the low round-trip efficiency due to activation energies in the conversion reactions limited their use. In 1976, Wittingham (J. Electrochem. Soc., 123, 315) and Besenhard (J. Power Sources 1(3), 267) finally enabled highly reversible redox reactions by intercalation of lithium ions instead of by chemical conversion. In 1980, Goodenough and Mizushima (Mater. Res. Bull. 15, 783-789) demonstrated a high-energy and high-power LiCoO2 cathode, allowing for an increase of terminal voltage far beyond 3 V. Over the past four decades, the international research community has further developed cathode materials of many varieties. Current state-of-the-art cathodes demonstrate voltages beyond any known electrolyte stability window, bringing electrolyte research once again to the forefront of battery research.

2013 Estorm - Invited Paper - Cathode Materials Review

Energy Technology Data Exchange (ETDEWEB)

Daniel, Claus [ORNL; Mohanty, Debasish [ORNL; Li, Jianlin [ORNL; Wood III, David L [ORNL

2014-01-01

The electrochemical potential of cathode materials defines the positive side of the terminal voltage of a battery. Traditionally, cathode materials are the energy-limiting or voltage-limiting electrode. One of the first electrochemical batteries, the voltaic pile invented by Alessandro Volta in 1800 (Phil. Trans. Roy. Soc. 90, 403 431) had a copper-zinc galvanic element with a terminal voltage of 0.76 V. Since then, the research community has increased capacity and voltage for primary (nonrechargeable) batteries and round-trip efficiency for secondary (rechargeable) batteries. Successful secondary batteries have been the lead acid with a lead oxide cathode and a terminal voltage of 2.1 V and later the NiCd with a nickel(III) oxide hydroxide cathode and a 1.2 V terminal voltage. The relatively low voltage of those aqueous systems and the low round-trip efficiency due to activation energies in the conversion reactions limited their use. In 1976, Wittingham (J. Electrochem. Soc., 123, 315) and Besenhard (J Power Sources 1(3), 267) finally enabled highly reversible redox reactions by intercalation of lithium ions instead of by chemical conversion. In 1980, Goodenough and Mizushima (Mater. Res. Bull. 15, 783 789) demonstrated a high-energy and high-power LiCoO2 cathode, allowing for an increase of terminal voltage far beyond 3 V. Over the past four decades, the international research community has further developed cathode materials of many varieties. Current state-of-the-art cathodes demonstrate voltages beyond any known electrolyte stability window, bringing electrolyte research once again to the forefront of battery research.

Cathode materials review

International Nuclear Information System (INIS)

Daniel, Claus; Mohanty, Debasish; Li, Jianlin; Wood, David L.

2014-01-01

The electrochemical potential of cathode materials defines the positive side of the terminal voltage of a battery. Traditionally, cathode materials are the energy-limiting or voltage-limiting electrode. One of the first electrochemical batteries, the voltaic pile invented by Alessandro Volta in 1800 (Phil. Trans. Roy. Soc. 90, 403-431) had a copper-zinc galvanic element with a terminal voltage of 0.76 V. Since then, the research community has increased capacity and voltage for primary (nonrechargeable) batteries and round-trip efficiency for secondary (rechargeable) batteries. Successful secondary batteries have been the lead-acid with a lead oxide cathode and a terminal voltage of 2.1 V and later the NiCd with a nickel(III) oxide-hydroxide cathode and a 1.2 V terminal voltage. The relatively low voltage of those aqueous systems and the low round-trip efficiency due to activation energies in the conversion reactions limited their use. In 1976, Wittingham (J. Electrochem. Soc., 123, 315) and Besenhard (J. Power Sources 1(3), 267) finally enabled highly reversible redox reactions by intercalation of lithium ions instead of by chemical conversion. In 1980, Goodenough and Mizushima (Mater. Res. Bull. 15, 783-789) demonstrated a high-energy and high-power LiCoO 2 cathode, allowing for an increase of terminal voltage far beyond 3 V. Over the past four decades, the international research community has further developed cathode materials of many varieties. Current state-of-the-art cathodes demonstrate voltages beyond any known electrolyte stability window, bringing electrolyte research once again to the forefront of battery research

Cathode materials review

Energy Technology Data Exchange (ETDEWEB)

Daniel, Claus, E-mail: danielc@ornl.gov; Mohanty, Debasish, E-mail: danielc@ornl.gov; Li, Jianlin, E-mail: danielc@ornl.gov; Wood, David L., E-mail: danielc@ornl.gov [Oak Ridge National Laboratory, 1 Bethel Valley Road, MS6472 Oak Ridge, TN 37831-6472 (United States)

2014-06-16

The electrochemical potential of cathode materials defines the positive side of the terminal voltage of a battery. Traditionally, cathode materials are the energy-limiting or voltage-limiting electrode. One of the first electrochemical batteries, the voltaic pile invented by Alessandro Volta in 1800 (Phil. Trans. Roy. Soc. 90, 403-431) had a copper-zinc galvanic element with a terminal voltage of 0.76 V. Since then, the research community has increased capacity and voltage for primary (nonrechargeable) batteries and round-trip efficiency for secondary (rechargeable) batteries. Successful secondary batteries have been the lead-acid with a lead oxide cathode and a terminal voltage of 2.1 V and later the NiCd with a nickel(III) oxide-hydroxide cathode and a 1.2 V terminal voltage. The relatively low voltage of those aqueous systems and the low round-trip efficiency due to activation energies in the conversion reactions limited their use. In 1976, Wittingham (J. Electrochem. Soc., 123, 315) and Besenhard (J. Power Sources 1(3), 267) finally enabled highly reversible redox reactions by intercalation of lithium ions instead of by chemical conversion. In 1980, Goodenough and Mizushima (Mater. Res. Bull. 15, 783-789) demonstrated a high-energy and high-power LiCoO{sub 2} cathode, allowing for an increase of terminal voltage far beyond 3 V. Over the past four decades, the international research community has further developed cathode materials of many varieties. Current state-of-the-art cathodes demonstrate voltages beyond any known electrolyte stability window, bringing electrolyte research once again to the forefront of battery research.

Micro-Sugar-Snap and -Wire-Cut Cookie Baking with Trans- and Zero-Trans-Fat Shortenings

Science.gov (United States)

The effect of trans- and zero-trans-fat shortenings on cookie-baking performance was evaluated, using the two AACC micro-cookie-baking methods. Regardless of fat type, sugar-snap cookies made with a given flour were larger in diameter, smaller in height, and greater in weight loss during baking tha...

Understanding the complexity of trans fatty acid reduction in the American diet: American Heart Association Trans Fat Conference 2006: report of the Trans Fat Conference Planning Group.

Science.gov (United States)

Eckel, Robert H; Borra, Susan; Lichtenstein, Alice H; Yin-Piazza, Shirley Y

2007-04-24

A 2-day forum was convened to discuss the current status and future implications of reducing trans fatty acids without increasing saturated fats in the food supply while maintaining functionality and consumer acceptance of packaged, processed, and prepared foods. Attendees represented the agriculture and oilseed industry and oil processing, food manufacturing, food service, government, food technology, and health and nutrition disciplines. Presentations included food science behind fatty acid technology, the health science of dietary fatty acids, alternatives to trans fatty acids, and the use of alternatives in food manufacturing and food service. The reduction of trans fatty acids in the food supply is a complex issue involving interdependent and interrelated stakeholders. Actions to reduce trans fatty acids need to carefully consider both intended and unintended consequences related to nutrition and public health. The unintended consequence of greatest concern is that fats and oils high in saturated fats, instead of the healthier unsaturated fats, might be used to replace fats and oils with trans fatty acids. Many different options of alternative oils and fats to replace trans fatty acids are available or in development. Decisions on the use of these alternatives need to consider availability, health effects, research and development investments, reformulated food quality and taste, supply-chain management, operational modifications, consumer acceptance, and cost. The conference demonstrated the value of collaboration between the food industry and health and nutrition professionals, and this conference model should be used to address other food development, processing, and/or technology issues.

Becoming lesbian: Monique Wittig's queer-trans-feminism.

Science.gov (United States)

Henderson, Kevin

2018-04-03

Inspired by Lynne Huffer's queer feminist genealogy, this article explores queer-trans-feminism as a project that would bring together queer, feminist, and transgender theory and politics into a shared critical lineage. I suggest that Monique Wittig is a neglected thinker who could re-enliven connections and debates within queer, feminist, and trans theory and politics. Utilizing recent historiographies of queer and feminist theory, I imagine what it would mean to hold on to the figure of the lesbian as a figure for queer-trans-feminist politics rather than render the lesbian anachronistic. I then explore the implications of Wittig's notion that "lesbians are not women" for a queer-trans-feminism. I argue that Wittig's critique of the language of the social sciences offers queer-trans-feminist scholars a source for contemporary self-critique and coalition.

Trans-Kullo jagatakse tükkideks / Kadrin Karner

Index Scriptorium Estoniae

Karner, Kadrin

2008-01-01

Primos OÜ omanik ja Trans-Kullo osanik Endel Siff ütles, et Trans-Kullo on aktsionäride erinevate ärihuvide tõttu läinud jagunemisele, mis võib lõppeda ettevõtte likvideerimisega. Lisa: Trans-Kullo

Sexual desire in trans persons: associations with sex reassignment treatment.

Science.gov (United States)

Wierckx, Katrien; Elaut, Els; Van Hoorde, Birgit; Heylens, Gunter; De Cuypere, Griet; Monstrey, Stan; Weyers, Steven; Hoebeke, Piet; T'Sjoen, Guy

2014-01-01

Sex steroids and genital surgery are known to affect sexual desire, but little research has focused on the effects of cross-sex hormone therapy and sex reassignment surgery on sexual desire in trans persons. This study aims to explore associations between sex reassignment therapy (SRT) and sexual desire in a large cohort of trans persons. A cross-sectional single specialized center study including 214 trans women (male-to-female trans persons) and 138 trans men (female-to-male trans persons). Questionnaires assessing demographics, medical history, frequency of sexual desire, hypoactive sexual desire disorder (HSDD), and treatment satisfaction. In retrospect, 62.4% of trans women reported a decrease in sexual desire after SRT. Seventy-three percent of trans women never or rarely experienced spontaneous and responsive sexual desire. A third reported associated personal or relational distress resulting in a prevalence of HSDD of 22%. Respondents who had undergone vaginoplasty experienced more spontaneous sexual desire compared with those who planned this surgery but had not yet undergone it (P = 0.03). In retrospect, the majority of trans men (71.0%) reported an increase in sexual desire after SRT. Thirty percent of trans men never or rarely felt sexual desire; 39.7% from time to time, and 30.6% often or always. Five percent of trans men met the criteria for HSDD. Trans men who were less satisfied with the phalloplasty had a higher prevalence of HSDD (P = 0.02). Trans persons who were more satisfied with the hormonal therapy had a lower prevalence of HSDD (P = 0.02). HSDD was more prevalent in trans women compared with trans men. The majority of trans women reported a decrease in sexual desire after SRT, whereas the opposite was observed in trans men. Our results show a significant sexual impact of surgical interventions and both hormonal and surgical treatment satisfaction on the sexual desire in trans persons. © 2013 International Society for Sexual

Roy-Steiner equations for γγ→ππ

International Nuclear Information System (INIS)

Hoferichter, Martin; Phillips, Daniel R.; Schat, Carlos

2011-01-01

Starting from hyperbolic dispersion relations, we derive a system of Roy-Steiner equations for pion Compton scattering that respects analyticity, unitarity, gauge invariance, and crossing symmetry. It thus maintains all symmetries of the underlying quantum field theory. To suppress the dependence of observables on high-energy input, we also consider once- and twice-subtracted versions of the equations, and identify the subtraction constants with dipole and quadrupole pion polarizabilities. Based on the assumption of Mandelstam analyticity, we determine the kinematic range in which the equations are valid. As an application, we consider the resolution of the γγ→ππ partial waves by a Muskhelishvili-Omnes representation with finite matching point. We find a sum rule for the isospin-two S-wave, which, together with chiral constraints, produces an improved prediction for the charged-pion quadrupole polarizability (α 2 -β 2 ) π± =(15.3±3.7) x 10 -4 fm 5 . We investigate the prediction of our dispersion relations for the two-photon coupling of the σ-resonance Γ σγγ . The twice-subtracted version predicts a correlation between this width and the isospin-zero pion polarizabilities, which is largely independent of the high-energy input used in the equations. Using this correlation, the chiral perturbation theory results for pion polarizabilities, and our new sum rule, we find Γ σγγ =(1.7 ±0.4) keV. (orig.)

Download this PDF file

African Journals Online (AJOL)

Urquhart GM, Armour J, Duncan JL, Dunn AM, and Jennings F.W., 1994. Veterinary. Parasitology. 1st edition.Singapore, Longmann. Urquhart, G.M., Murray M., Murray P. K., Jennings F.W. and Bate, E., 1973. Immunosuppressant in Trypanosoma brucei infections in rats and mice. Trans Roy. Soc. Trop. Med., 67, 528-535.

Starch plus sunflower oil addition to the diet of dry dairy cows results in a trans-11 to trans-10 shift of biohydrogenation.

Science.gov (United States)

Zened, A; Enjalbert, F; Nicot, M C; Troegeler-Meynadier, A

2013-01-01

Trans fatty acids (FA), exhibit different biological properties. Among them, cis-9,trans-11 conjugated linoleic acid has some interesting putative health properties, whereas trans-10,cis-12 conjugated linoleic acid has negative effects on cow milk fat production and would negatively affect human health. In high-yielding dairy cows, a shift from trans-11 to trans-10 pathway of biohydrogenation (BH) can occur in the rumen of cows receiving high-concentrate diets, especially when the diet is supplemented with unsaturated fat sources. To study this shift, 4 rumen-fistulated nonlactating Holstein cows were assigned to a 4×4 Latin square design with 4 different diets during 4 periods. Cows received 12 kg of dry matter per day of 4 diets based on corn silage during 4 successive periods: a control diet (22% starch, diet supplemented with wheat plus barley (35% starch, diet supplemented with 5% of sunflower oil (20% starch, 7.6% crude fat), and a high-starch plus sunflower oil diet (33% starch, 7.3% crude fat). Five hours after feeding, proportions of trans-11 BH isomers greatly increased in the rumen content with the addition of sunflower oil, without change in ruminal pH compared with the control diet. Addition of starch to the control diet had no effect on BH pathways but decreased ruminal pH. The addition of a large amount of starch in association with sunflower oil increased trans-10 FA at the expense of trans-11 FA in the rumen content, revealing a trans-11 to trans-10 shift. Interestingly, with this latter diet, ruminal pH did not change compared with a single addition of starch. This trans-11 to trans-10 shift occurred progressively, after a decrease in the proportion of trans-11 FA in the rumen, suggesting that this shift could result from a dysbiosis in the rumen in favor of trans-10-producing bacteria at the expense of those producing trans-11 or a modification of bacterial activities. Copyright © 2013 American Dairy Science Association. Published by Elsevier

Analysis of Trans Fat in Edible Oils with Cooking Process

Science.gov (United States)

Song, Juhee; Park, Joohyeok; Jung, Jinyeong; Lee, Chankyu; Gim, Seo Yeoung; Ka, HyeJung; Yi, BoRa; Kim, Mi-Ja; Kim, Cho-il

2015-01-01

Trans fat is a unsaturated fatty acid with trans configuration and separated double bonds. Analytical methods have been introduced to analyze trans fat content in foods including infrared (IR) spectroscopy, gas chromatography (GC), Fourier transform-infrared (FT-IR) spectroscopy, reverses-phase silver ion high performance liquid chromatography, and silver nitrate thin layer chromatography. Currently, FT-IR spectroscopy and GC are mostly used methods. Trans fat content in 6 vegetable oils were analyzed and processing effects including baking, stir-frying, pan-frying, and frying on the formation of trans fat in corn oil was evaluated by GC. Among tested vegetable oils, corn oil has 0.25 g trans fat/100 g, whereas other oils including rapeseed, soybean, olive, perilla, and sesame oils did not have detectable amount of trans fat content. Among cooking methods, stir-frying increased trans fat in corn oil whereas baking, pan-frying, and frying procedures did not make changes in trans fat content compared to untreated corn oils. However, the trans fat content was so low and food label can be declared as ‘0’ trans based on the regulation of Ministry of Food ad Drug Safety (MFDS) (edible oil). PMID:26483890

Ácidos graxos trans: implicações nutricionais e fontes na dieta Trans fatty acids: nutritional implications and sources in the diet

Directory of Open Access Journals (Sweden)

Clayton Antunes Martin

2004-09-01

Full Text Available Este artigo revisa as principais fontes de ácidos graxos trans na dieta e as implicações nutricionais da ingestão elevada destes isômeros. São apresentados resumidamente os métodos analíticos utilizados na identificação e quantificação dos ácidos graxos trans, sendo abordados as suas vantagens e desvantagens. Os alimentos que empregam gordura parcialmente hidrogenada na sua produção, são fontes importantes de isômeros trans na dieta da maior parte da população em países industrializados. Este estudo compara os níveis de ácidos graxos trans em gorduras hidrogenadas, margarinas e batatas frita, analisados em diversos países, incluindo o Brasil. Esta avaliação indica a presença de níveis elevados de isômeros trans em alimentos produzidos no Brasil.This article review the main sources of trans fatty acids in the diet and nutritional implications of the high intake of these isomers. Analytical methods for the identification and quantification of trans fatty acids are presented briefly with regard to advantages and drawbacks of each method. Foods make with partially hidrogenated fats are important sources of trans isomers in the diets of most people in industrialized countries. It is made a comparison between levels of trans fatty acids in shortenings, margarines and potato chips evaluated in Brazil and in other countries. High levels of trans isomers are noted in Brazilian foods.

Trans-nationalisation Processes in the Ukrainian Economy

OpenAIRE

Bolharova Natalya K.; Panevnyk Tetyana M.

2013-01-01

The article considers main processes of trans-nationalisation of Ukrainian economy, identifies specific features of trans-national production and explains some theoretical aspects of these issues. It provides main stages of theoretical comprehension of activity of trans-national corporations (TNC), specific features of the theory of competitive advantages of TNC and specifies the basic ones of them. The article conducts analysis of flows of direct foreign investments into the Ukrainian econom...

Finding a Trans-Affirmative Provider: Challenges Faced by Trans and Gender Diverse Psychologists and Psychology Trainees.

Science.gov (United States)

Dickey, Lore M; Singh, Anneliese A

2017-08-01

This article explores some of the challenges faced by trans and gender diverse (TGD) individuals who not only are attempting to access trans-affirmative care, but who are also members of the very profession from which they are seeking services. The authors explore challenges related to finding supervision, accessing care for assessment services, and finding a provider for personal counseling. With each example, the authors unpack the challenges and also address the implications for training for all involved. Based on these challenges that TGD psychologists and trainees face in attempting to access care, the authors provide recommendations related to trans-affirmative training for psychologists. © 2017 Wiley Periodicals, Inc.

Metabolism of trans, trans-muconaldehyde, a cytotoxic metabolite of benzene, in mouse liver by alcohol dehydrogenase Adh1 and aldehyde reductase AKR1A4

International Nuclear Information System (INIS)

Short, Duncan M.; Lyon, Robert; Watson, David G.; Barski, Oleg A.; McGarvie, Gail; Ellis, Elizabeth M.

2006-01-01

The reductive metabolism of trans, trans-muconaldehyde, a cytotoxic metabolite of benzene, was studied in mouse liver. Using an HPLC-based stopped assay, the primary reduced metabolite was identified as 6-hydroxy-trans, trans-2,4-hexadienal (OH/CHO) and the secondary metabolite as 1,6-dihydroxy-trans, trans-2,4-hexadiene (OH/OH). The main enzymes responsible for the highest levels of reductase activity towards trans, trans-muconaldehyde were purified from mouse liver soluble fraction first by Q-sepharose chromatography followed by either blue or red dye affinity chromatography. In mouse liver, trans, trans-muconaldehyde is predominantly reduced by an NADH-dependent enzyme, which was identified as alcohol dehydrogenase (Adh1). Kinetic constants obtained for trans, trans-muconaldehyde with the native Adh1 enzyme showed a V max of 2141 ± 500 nmol/min/mg and a K m of 11 ± 4 μM. This enzyme was inhibited by pyrazole with a K I of 3.1 ± 0.57 μM. Other fractions were found to contain muconaldehyde reductase activity independent of Adh1, and one enzyme was identified as the NADPH-dependent aldehyde reductase AKR1A4. This showed a V max of 115 nmol/min/mg and a K m of 15 ± 2 μM and was not inhibited by pyrazole

Trans issues in Liz Lochhead's 'Not Changed'

OpenAIRE

Kaličanin Milena M.

2017-01-01

The paper is divided into four sections. In the first section entitled 'Introducing and Defining Trans (Issues)', the basic terms of transgender, transvestite, and transsexual are defined by relying on Stryker's Transgender History (2008). The second part of the paper, 'Trans Studies: In-Between Feminist and Queer Theory?', places transgender studies into an academic context by referring to the theoretical framework provided by trans theorists Stryker, Stone, and Ranck who unanimously claim t...

Trans fats in New Zealand: time for labelling regulations?

Science.gov (United States)

Gladding, Patrick; Benatar, Jocelyne R

2007-11-09

Trans fats (trans fatty acids) are commonly used for deep frying in restaurants and in the fast food, snack food, fried food, and baked goods industries, often to extend the shelf life of foods. However they are widely considered to be harmful to health. Trans fats were banned in New York City restaurants from 1 July 2007, and there is growing vocal opposition to trans fats in the European Union. Denmark became the first country, in March 2003, to introduce laws regulating the content of trans fats in food (maximum of 2% of edible fats and oils). What are trans fats, what harm do they cause, and should New Zealand also consider imposing mandatory regulations on their use in food? This article explores the issues.

Physics of Trans-Planckian Gravity

CERN Document Server

Dvali, Gia; Germani, Cristiano

2011-01-01

We study aspects of the phenomenon of gravitational UV-self-completeness and its implications for deformations of Einstein gravity. In a ghost-free theory flowing to Einstein gravity in the IR trans-Planckian propagating quantum degrees of freedom cannot exist. The only physical meaning of a trans-Planckian pole is the one of a classical state (Black Hole) which is fully described by the light IR quantum degrees of freedom and gives exponentially-suppressed contributions to virtual processes. In this sense Einstein gravity is UV self-complete, although not Wilsonian. We show that this UV/IR correspondence puts a severe constraint on any attempt of conventional Wilsonian UV-completion of trans-Planckian gravity. In particular, there is no well-defined energy domain in which gravity could become asymptotically weak or safe.

(Gmelin, 1791) and Patella concolor Krauss, 1848 (Gastropoda

African Journals Online (AJOL)

1986-11-21

Nov 21, 1986 ... Trans Roy. Soc. S. Afr. 41: 111-160. BRANCH, G.M. 1975. Notes on the ecology of Patella concolor and Cellana capensis and the effects of human consumption on limpet populations. 2001 Afr. 10: 75-85. BRANCH, G.M. 1981. The biology of limpets: physical factors, energy flow, and ecological interactions.

Is there such a thing as Tech Trans?

DEFF Research Database (Denmark)

Helms, Niels Henrik

2009-01-01

This short paper is an attempt to start a discussion on some basic issues within the concept of Tech Trans especially the relationship between flow and structure within the concept. The background to this paper is first of all an academic interest in the relationship between flow and structure...... explores the concept of Tech Trans, show rooms and innovation systems, and it suggests that the notion of Tech Trans should be defined in the fix point of vertical and horizontal innovation. Finally this paper suggests a mathematical formula for evaluating Tech Trans....

Acetylcholinesterase Inhibition and Antioxidant Activity of N-trans-Caffeoyldopamine and N-trans-Feruloyldopamine

Directory of Open Access Journals (Sweden)

Muamer Dizdar

2018-04-01

Full Text Available Phenolic acids and their derivatives found in nature are well-known for their potential biological activity. In this study, two amides derived from trans-caffeic/ferulic acid and dopamine were synthesized and characterized by Fourier-transform infrared spectroscopy (FTIR, mass spectrometry, proton and carbon-13 nuclear magnetic resonance spectroscopy. The compounds were tested for the inhibition of acetylcholinesterase (AChE from Electrophorus electricus and for antioxidant activity by scavenging 2,2-diphenyl-1-pycrylhydrazyl free radical (DPPH• and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulphonic acid radical cation (ABTS•+, reducing ferric ions, and ferrous ions chelation. N-trans-Feruloyldopamine displayed the highest inhibitory effect on AChE with half-maximal inhibitory concentration (IC50 values of 8.52 μM. In addition, an in silico study was done to determine the most favorable AChE cluster with the synthesized compounds. Further, these clusters were investigated for binding positions at the lowest free binding energy. Both synthesized hydroxycinnamates were found to be better antioxidants than the parent acids in in vitro tests applied. N-trans-Caffeoyldopamine showed the best antioxidant activity in the three tested methods—against non-biological stable free radicals IC50 5.95 μM for DPPH•, 0.24 μM for the ABTS•+ method, and for reducing power (ascorbic acid equivalent (AAE 822.45 μmol/mmol—while for chelation activity against Fe2+ ions N-trans-feruloyldopamine had slightly better antioxidant activity (IC50 3.17 mM.

Trans issues in Liz Lochhead's 'Not Changed'

Directory of Open Access Journals (Sweden)

Kaličanin Milena M.

2017-01-01

Full Text Available The paper is divided into four sections. In the first section entitled 'Introducing and Defining Trans (Issues', the basic terms of transgender, transvestite, and transsexual are defined by relying on Stryker's Transgender History (2008. The second part of the paper, 'Trans Studies: In-Between Feminist and Queer Theory?', places transgender studies into an academic context by referring to the theoretical framework provided by trans theorists Stryker, Stone, and Ranck who unanimously claim that transgender studies should have a place of its own within the academia and that trans theory should solely be written by transsexuals. These ideas are applied in the interpretation of Lochhead's story 'Not Changed' in the third segment of the paper. The critical insights of Butler (Gender Trouble, 1990; Undoing Gender, 2004 are found to be most helpful in the interpretation of Lochhead's story about Michael who has willingly undergone Hormone Replacement Therapy to become transsexual Michele. Finally, in the concluding remarks, Lochhead's story is viewed as a trans woman manifesto, urging both non-transsexual and transsexual persons to embrace new beginnings in their relationship.

Trans-nationalisation Processes in the Ukrainian Economy

Directory of Open Access Journals (Sweden)

Bolharova Natalya K.

2013-12-01

Full Text Available The article considers main processes of trans-nationalisation of Ukrainian economy, identifies specific features of trans-national production and explains some theoretical aspects of these issues. It provides main stages of theoretical comprehension of activity of trans-national corporations (TNC, specific features of the theory of competitive advantages of TNC and specifies the basic ones of them. The article conducts analysis of flows of direct foreign investments into the Ukrainian economy. It shows distribution of direct foreign investments into Ukraine by main countries-investors, regions-recipients and types of economic activity. It conducts review and analysis of the modern state of trans-national corporations of foreign origin in the Ukrainian market. It considers functioning of domestic TNC in Ukraine and main tendencies of entering of Ukrainian companies into the world environment and also identifies directions of further development of these phenomena. Prospects of further studies in this direction are identification of the degree of trans-nationalisation processes in the Ukrainian economy and identification of the positive effect, in particular, synergy from integration and globalisation.

Formation of trans fats during food preparation.

Science.gov (United States)

Przybylski, Oman; Aladedunye, Felix A

2012-01-01

An investigation was completed to determine how typical cooking procedures used in food preparation, such as baking and stir-frying, affect trans fats formation. Canola oil was used as the main fat ingredient. Zucchini cake and gingersnap cookies were baked at 180o C and 200o C, while stir-fried chicken was prepared at 200o C and 275o C. The lipids from the food were extracted following the Folch procedure, and analyzed for trans fatty acids according to ISO official method 15304. Minimal changes were observed in the amount of trans fats during baking. Application of extreme temperatures during baking, which caused carbonization of the outer layer of products, yielded an insignificant increase in the amount of trans isomers. As with baking, stir-frying did not result in significant isomerization of the fatty acids, even when the oil was heated to 275o C and smoking heavily before the food was placed in it. Irrespective of the cooking procedure, linolenic acid was the most prone to isomerization with the highest amount of trans isomers formation. Baking and stir-frying at normal and/or extreme temperatures do not significantly affect the amounts of trans fats. Likewise, heating oil to the smoking point during stir-frying may decrease the amount of polyunsaturated fatty acids because of oxidative degradation.

Binge-type behavior in rats consuming trans-fat-free shortening.

Science.gov (United States)

Wojnicki, F H E; Charny, G; Corwin, R L W

2008-07-05

Studies from this and another laboratory involving an animal model of binge-type behavior have used vegetable shortening containing trans-fats. Due to reformulations by vegetable shortening manufacturers to remove trans-fats from their products, only trans-fat-free shortenings are now available. The goal of the present study was to assess binge-type behavior in rats with trans-fat and trans-free vegetable shortening. Trans-fat-free shortening was provided to three different groups of non-food-deprived male Sprague Dawley rats on different schedules of access: continuous access (24 h/day-7 days/week), daily access (1 h every day), and intermittent access (1 h on Mondays, Wednesdays, Fridays). Trans-fat shortening was provided to a fourth group on the intermittent access schedule. A fifth group had no shortening access (chow only). Both intermittent groups (trans-fat-free and trans-fat) consumed significantly more shortening during the 1-h period of availability than did the daily group, and there was no difference in shortening intakes between the intermittent groups. These results are identical to previous reports of binge-type behavior in rats using this model. Thus, binge-type behavior in the present behavioral model depends upon the schedule of access, not the presence of trans-fats in the shortening.

Cis-trans photoisomerization of abscisic acid

International Nuclear Information System (INIS)

Brabham, D.E.; Biggs, R.H.

1981-01-01

An important regulator of numerous physiological processes in higher plants is abscisic acid (ABA), which is photoisomerized from the more biologically active cis isomer to the nearly inactive trans isomer by natural sunlight. It is possible that this photoisomerization is a UV control mechanism in functions regulated by ABA. The quantum yields of both the cis to trans and trans to cis photoisomerizations were measured under various conditions of pH and oxygen concentration at room temperature. The yield for photoisomerization of cis-ABA ranged from 0.25 at pH 3.0 to 0.11 at pH 7.0. Oxygen partially quenched the process. The quantum yield varied only slightly with wavelength. The quantum yield of photolysis of cis-ABA was reported for pH 3.0 as 0.06. This yield also varied slightly with wavelength and was relatively insensitive to oxygen. This relatively high yield explains the loss of potency of ABA during UV irradiation. Phosphorescence of cis- and trans-ABA was observed in methanol at 77 K. Onset of the emission was at 350 nm. The emission spectra were the same for both isomers. From these results a mechanism of UV action on plants based on the photoisomerization of the inactive trans-ABA to the biologically active cis isomer is proposed. (author)

Statement of Roy F. Pruett, Mayor, City of Oak Ridge, TN

International Nuclear Information System (INIS)

Anon.

1987-01-01

Thank you very much, Mr. Chairman, and Members of the Committee. My name is Roy Pruett, mayor of the city of Oak Ridge, TN, and an executive committee member on the Clinch River MRS task force. It is my pleasure to be here today to testify before this distinguished Committee and present the findings of the Clinch River task force as they relate to subtitle C of the Nuclear Waste Policy Act of 1982, and to the Department of Energy proposal on the Monitored Retrievable Storage facility, the MRS. I represent the city of Oak Ridge, which has been selected for the primary and the first alternative for the siting of an integrated MRS facility for the preparation and packaging of high-level nuclear waste and spent reactor fuel. Of civic and governmental leaders, we concluded that an MRS could safely be built and operated in Oak Ridge. We further concluded, however, that the facility would not be generally perceived as being safe unless the recommendations of the task force were adopted to address concerns and help mitigate impact. Indeed the MRS would not be viewed as a net economic benefit to the site's community, the region, or the State of Tennessee without such appropriate conditions

Sero-prevalence of hepatitis B surface antigen among primary ...

African Journals Online (AJOL)

of 2-7% in Southern and Eastern Europe to low rates of less than 2%, in .... Table 2. Distribution of HBsAg by Age and Gender amongst Primary School Pupils in the Hawal valley ... effective manner and the global assessment of hepatitis B. 13 ... settlement in the Middle Hawal Valley, Nigeria, Trans Roy. Soc Trop Med Hyg ...

A CONTRIBUTION TOWARDS A REVISION OF THE AQUATIC ...

African Journals Online (AJOL)

in the rather small number of papers dealing with the fauna of Africa, including Madagascar. New material has ... u ced b y Sa b in et G a tew a. y u n d er licen ce gra n ted b y th e P u b lish er (d a ted. 2010). ...... flora and fauna. Trans. roy. Soc.

[CONTENT OF TRANS FATTY ACIDS IN FOOD PRODUCTS IN SPAIN].

Science.gov (United States)

Robledo de Dios, Teresa; Dal Re Saavedra, M Ángeles; Villar Villalba, Carmen; Pérez-Farinós, Napoleón

2015-09-01

trans fatty acids are associated to several health disorders, as ischemic heart disease or diabetes mellitus. to assess the content of trans fatty acids in products in Spain, and the percentage of trans fatty acids respecting total fatty acids. 443 food products were acquired in Spain, and they were classified into groups. The content in fatty acids was analyzed using gas chromatography. Estimates of central tendency and variability of the content of trans fatty acids in each food group were computed (in g of trans fatty acids/100 g of product). The percentage of trans fatty acids respecting total fatty acids was calculated in each group. 443 products were grouped into 42 groups. Median of trans fatty acids was less than 0.55 g / 100 g of product in all groups except one. 83 % of groups had less than 2 % of trans fatty acids, and 71 % of groups had less than 1 %. the content of trans fatty acids in Spain is low, and it currently doesn't play a public health problem. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

Trans-nationalizing the African Public Sphere: What Role for Trans ...

African Journals Online (AJOL)

seriane.camara

2011-03-09

Mar 9, 2011 ... At a time when the notion of 'trans-national public spheres' is gaining .... ple refer specifically to the language and its speakers in Senegal and Mauri- .... of the Pulaar language and the improvement of the social and economic.

Peel Region TransHelp's experience

Energy Technology Data Exchange (ETDEWEB)

NONE

2009-09-15

TransHelp was founded in the Peel Region of Ontario in 1981 to provide paratransit service to individuals unable to use conventional transit. The TransHelp vehicle fleet consists of 40 buses that make over 220,000 one way trips annually. Each vehicle has a typical life span of between 375,000 and 425,000 km. TransHelp vehicles spend much of their time idling in emissions-sensitive areas, such as outside hospitals. In order to reduce fuel costs, TransHelp adopted the use of propane to fuel its vehicles. However, difficulties were experienced with this technology, particularly on V-10 engines where increased maintenance was a problem. SFI Technologies Inc. provided a solution with their SEQUIN System which allows seamless transitioning between gasoline and propane under all conditions without any operator involvement in fuel selection. The technology favours propane as the fuel of choice and automatically switches between propane and gasoline based on the ideal conditions at the time of operation. The technology has received certification from the Environmental Protection Agency in the United States and the Canadian Standards Association. The use of the SEQUIN System has proven to successful for TransHelp. It has allowed the use of propane to be continued, meaning that vehicle emissions are greatly reduced relative to gasoline or diesel fuelled vehicles. TransHelp has realized a fuel savings of 15-20 per cent over gasoline and receives an additional federal transit rebate of 15 per cent for the conversion cost.

Trans Women Doing Sex in San Francisco.

Science.gov (United States)

Williams, Colin J; Weinberg, Martin S; Rosenberger, Joshua G

2016-10-01

This research investigates the sexuality of trans women (individuals who were assigned male status at birth who currently identify as women), by focusing on the "bodily techniques" (Crossley, 2006) they use in "doing" sexuality. The "doing sexuality" framework not only is modeled after the "doing gender" approach of West and Zimmerman (1987), but also utilizes the idea of "sexual embodiment" to emphasize the agency of trans women as they conceptualize and organize their sexuality in a socially recognized way. This is often difficult as they confront discrimination from medical and legal professionals as well as intimate partners who may find it difficult to adapt to the trans woman's atypical body and conception of gender. However, with a study group of 25 trans women from San Francisco, we found the study participants to be adept at overcoming such hurdles and developing techniques to "do" their sexuality. At the same time, we found trans women's agency constrained by the erotic habitus (Green, 2008) of the wider society. The interplay between innovation and cultural tradition provides an opportunity to fashion a more general model of "doing" sexuality.

Trans-Z-source Neutral Point Clamped inverter

DEFF Research Database (Denmark)

Mo, W.; Loh, P. C.; Li, D.

2012-01-01

Transformer based Z-source (trans-Z-source) inverters are recently proposed by extending the traditional Z-source inverter with higher buck-boost capability as well as reducing the passive components at the same time. Multi-Level Z-source inverters are single-stage topological solutions used...... for buck-boost energy conversion with all the favourable advantages of multi-level switching retained. This paper presents three-level trans-Z-source Neutral Point Clamped (NPC) inverter topology, which achieves both the advantages of trans-Z-source and three-level NPC inverter configuration. With proper...... modulation scheme, the three-level trans-Z-source inverter can function with minimum of six device commutations per half carrier cycle (same as the traditional buck NPC inverter), while maintaining to produce the designed volt-sec average and inductive voltage boosting at ac output terminals. The designed...

Repair Activity of trans-Resveratrol toward 2'-Deoxyguanosine Radicals.

Science.gov (United States)

Cheng, Xing; An, Ping; Li, Shujin; Zhou, Liping

2018-04-26

In the present study, the repair activity of trans-resveratrol toward 2'-deoxyguanosine (dGuo) radicals in polar and nonpolar solvents was studied using density functional theory. The hydrogen transfer/proton coupled electron transfer and single electron transfer (SET) mechanisms between trans-resveratrol and dGuo-radicals were considered. Taking into consideration the molar fraction of neutral trans-resveratrol (ROH) and anionic trans-resveratrol (RO - ), the overall rate constants for repairing dGuo-radicals by trans-resveratrol are 9.94 × 10 8 and 2.01 × 10 9 dm 3 mol -1 s -1 in polar and nonpolar solvents, respectively, and the overall rate constant of repairing cation radical (dGuo •+ ) by trans-resveratrol via an SET mechanism is 7.17 × 10 9 dm 3 mol -1 s -1 . The repair activity of RO - toward dGuo-radicals is better than that of ROH, but the repair activity of ROH toward dGuo •+ is better than that of RO - . Unfortunately, neither ROH nor RO - can repair the 2'-deoxyribose radicals of dGuo. It can therefore be concluded that trans-resveratrol is an effective antioxidant for repairing base radicals of dGuo and dGuo •+ . The study can help us understand the repair activity of trans-resveratrol toward dGuo radicals.

"Violence" in Sport and the Violenti non fit Iniuria Defence: A Perspective on the Death of the Cricket Player Phil Hughes

Directory of Open Access Journals (Sweden)

Pieter Labuschagne

2018-03-01

Full Text Available This article evaluates the defence of violenti non fit inuiria in sport with specific reference to the principle of bonos mores or the “good morals” in society to tolerate injuries in sport. The increased prevalence of serious injuries in sport in the professional era, in which sportsmen earn their livelihood from sport, necessitate a review of the existing situation. The death of the Australian cricket player, Phil Hughes, as a result of fast, short-pitched bowling in cricket, has again put the spotlight on the aggressive and excessive use of "violence" in sport. The malicious intent in sport, to harm or even to kill an opponent, has made it necessary to ask if there should be any difference in the manner in which the perpetrator of violence in sport should be treated as against ordinary criminal law assault and murder offenders. A two-pronged approach is suggested in the article as a possible way of dealing with wrongfulness in cricket.

The importance of trans-generational effects in Lepidoptera.

Science.gov (United States)

Woestmann, Luisa; Saastamoinen, Marjo

2016-10-01

The importance of trans-generational effects in shaping an individuals' phenotype and fitness, and consequently even impacting population dynamics is increasingly apparent. Most of the research on trans-generational effects still focuses on plants, mammals, and birds. In the past few years, however, increasing number of studies, especially on maternal effects, have highlighted their importance also in many insect systems. Lepidoptera, specifically butterflies, have been used as model systems for studying the role of phenotypic plasticity within generations. As ectotherms, they are highly sensitive to environmental variation, and indeed many butterflies show adaptive phenotypic plasticity in response to environmental conditions. Here, we synthesize what is known about trans-generational effects in Lepidoptera, compile evidence for different environmental cues that are important drivers of trans-generational effects, and point out which offspring traits are mainly impacted. Finally, we emphasize directions for future research that are needed for better understanding of the adaptive nature of trans-generational effects in Lepidoptera in particular, but potentially also in other organisms.

Bringing critical realism to nursing practice: Roy Bhaskar's contribution.

Science.gov (United States)

Williams, Lynne; Rycroft-Malone, Jo; Burton, Christopher R

2017-04-01

In the context of modern nursing practice that is embedded within complex social situations, critical discussions about the contribution of major philosophers are relevant and important. Whilst nurse theorists have advanced and shaped nursing as a discipline, other major philosophers can offer much to advance nursing enquiry. In this paper, we focus on philosopher Roy Bhaskar who, amongst others, developed critical realism, a philosophy for social science which connects with how many of us think about the world. Bhaskar's work focuses our attention on the interplay between structure and agency and on the search for the causative or generative mechanisms that explain the social world. Bhaskar was interested in human emancipation, and we suggest his work is of great importance to advance understanding of complex social situations. Critical realism has already been endorsed by a range of disciplines, especially in research which focuses on real problems and acknowledges the complexities of the social world. In recent evidence from healthcare literature, there has been a surge in research using realist methodology (realist evaluation and realist synthesis), which is underpinned by the philosophy of critical realism and which offers a different perspective to understanding nursing and healthcare problems through the realist lens. However, we suggest that sufficient attention is not always paid to the philosophical roots of this methodology. In this paper, we provide insight into Bhaskar's work and demonstrate how research positioned within critical realism and realist methodology can advance nursing and healthcare-related knowledge. Through shining a light on Bhaskar, we illustrate how critical realism philosophy is a natural fit with human and health science enquiry, including nursing. © 2016 John Wiley & Sons Ltd.

Sexualidade e experiências trans: do hospital à alcova Sexuality and trans experiences: from the hospital to the bedroom

Directory of Open Access Journals (Sweden)

Berenice Bento

2012-10-01

Full Text Available Depois dos estudos das masculinidades, não é possível pensar a produção das identidades de gênero sem referenciá-las ao caráter relacional. Esta mudança deveu-se à incorporação da perspectiva relacional nesse campo de estudos e à crítica ao conceito de gênero assentado em uma suposta natureza feminina e masculina para construir as interpretações sobre o lugar dos corpos da ordem de gênero. Os objetivos desse artigo são: 1 apontar como um determinado conceito de gênero pode visibilizar múltiplas expressões de gênero, a exemplo das identidades trans (transexuais, travestis, cross dress, drag queen, drag king, transgêneros ou invisibilizá-las e contribuir para sua patologização. O segundo objetivo será apresentar narrativas de homens trans e de mulheres trans, que nos contarão suas vivências sexuais. Os saberes médicos-psi advogam a inexistência de sexualidade em seus corpos, sendo este um dos indicadores para produção do diagnóstico de transexua­lidade. Tentarei argumentar que a base teórica que sustenta a patologização das identidades trans e a afirmação que as pessoas trans são assexuadas tem como fundamento uma concepção que atrela e condiciona as identidades de gênero às estruturas biológicas.In the aftermath of studies on masculinity, it is impossible to consider the production of gender identities without linking them to the relationship aspect. This change was due to the incorporation of the relationship perspective in this field of study and criticism of the concept of gender founded upon an alleged concept of femininity and masculinity to create interpretations of the place of bodies in the gender order. The objectives of this paper are: 1 to show how a given concept of gender can render multiple expressions of gender visible, like the trans identities (transsexuals, transvestites, cross dressers, drag queens, drag kings, transgenders or sublimate them and contribute to their pathologization

Are Fast Food “Trans-Fat” Claims True? An Infraspec VFA-IR Spectrometer Analysis of Trans-fat content in select food items purchased from Long John Silver’s

Directory of Open Access Journals (Sweden)

Sharron Jenkins

2014-10-01

Full Text Available Studies linking high trans-fat diets to coronary heart disease (CHD have prompted the need to regulate, limit, or completely ban trans-fat from all commercial food products, including fast foods. Many U.S. fast food chains now claim that their food items, particularly French fries, have "no trans-fat". In a previous study, our lab tested the validity of trans-fat claims made by several popular fast food restaurants by experimentally determining the %trans-fat in oil extracted from fast food French fries. In some cases, the trans-fat content was nearly twice as high as the amount reported by the restaurant in their literature. Long John Silver's, for example, reported a trans-fat content of 25% for their French fries, while our lab actually found over 40% trans-fat. The purpose of this study is to broaden our study of Long John Silver's trans-fat claims by analyzing a variety of their food items and comparing our findings with the %trans-fat reported by the restaurant literature (nutrition fact tables. Variable Filter Array (VFA IR spectroscopy was used to assess the trans-fat content of oil extracted from food samples. Our preliminary findings suggest that nearly every food item under study contained considerably more trans-fat than the amount reported in the restaurant’s literature.

Asymmetrically doped one-dimensional trans-polymers

International Nuclear Information System (INIS)

Caldas, Heron

2009-01-01

More than 30 years ago [H. Shirakawa, E.J. Louis, A.G. MacDiarmid, C.K. Chiang, A.J. Heeger, J. Chem. Soc. Chem. Comm. 578 (1977); S. Etemad, A.J. Heeger, Ann. Rev. Phys. Chem. 33 (1982) 443] it was discovered that doped trans-polyacetylene (CH) x , a one-dimensional (1D) conjugated polymer, exhibits electrical conductivity. In this work we show that an asymmetrically doped 1D trans-polymer has non-conventional properties, as compared to symmetrically doped systems. Depending on the level of asymmetry between the chemical potentials of the two involved fermionic species, the polymer can be in a partially or fully spin polarized state. Some possible experimental consequences of doped 1D trans-polymers used as 1D organic polarized conductors are discussed.

Bioavailability of trans-resveratrol from red wine in humans.

Science.gov (United States)

Vitaglione, Paola; Sforza, Stefano; Galaverna, Gianni; Ghidini, Cristiana; Caporaso, Nicola; Vescovi, Pier Paolo; Fogliano, Vincenzo; Marchelli, Rosangela

2005-05-01

Many in vitro studies demonstrated significant biological effects of trans-resveratrol. Thus, understanding the rate of intestinal absorption and metabolization in vivo of trans-resveratrol is the prerequisite to evaluate its potential health impact. Bioavailability studies mainly in animals or in humans using the pure compound at very high doses were performed. In this work, trans-resveratrol bioavailability from a moderate consumption of red wine in 25 healthy humans has been studied by three different experiments. The wine ingestion was associated to three different dietary approaches: fasting, a standard meal, a meal with high and low amount of lipids. Trans-resveratrol 3- and 4'-glucuronides were synthesized, purified, and characterized as pure standards. Bioavailability data were obtained by measuring the concentration of free, 3-glucuronide and 4'-glucuronide trans-resveratrol by high-performance liquid chromatography (HPLC), both with ultraviolet (UV) and mass spectrometry (MS) detection, in serum samples taken at different times after red wine administration. Free trans-resveratrol was found, in trace amounts, only in some serum samples collected 30 min after red wine ingestion while after longer times resveratrol glucuronides predominated. Trans-resveratrol bioavailability was shown to be independent from the meal or its lipid content. The finding in human serum of trans-resveratrol glucuronides, rather than the free form of the compound, with a high interindividual variability, raises some doubts about the health effects of dietary resveratrol consumption and suggests that the benefits associated to red wine consumption could be probably due to the whole antioxidant pool present in red wine.

Comparison of the patient radiation exposure during coronary angiography and angioplasty procedures using trans-radial and trans-femoral access

Directory of Open Access Journals (Sweden)

Ali Tarighatnia

2016-06-01

Conclusion: On the basis of the results obtained in this study, no differences were found in patients’ radiation dose in both access groups, therefore with regard to comparatively more clinical advantages associated with the Trans-radial access technique it might be a good substitute for Trans-femoral access.

The inverse-trans-influence in tetravalent lanthanide and actinide bis(carbene) complexes

Science.gov (United States)

Gregson, Matthew; Lu, Erli; Mills, David P.; Tuna, Floriana; McInnes, Eric J. L.; Hennig, Christoph; Scheinost, Andreas C.; McMaster, Jonathan; Lewis, William; Blake, Alexander J.; Kerridge, Andrew; Liddle, Stephen T.

2017-02-01

Across the periodic table the trans-influence operates, whereby tightly bonded ligands selectively lengthen mutually trans metal-ligand bonds. Conversely, in high oxidation state actinide complexes the inverse-trans-influence operates, where normally cis strongly donating ligands instead reside trans and actually reinforce each other. However, because the inverse-trans-influence is restricted to high-valent actinyls and a few uranium(V/VI) complexes, it has had limited scope in an area with few unifying rules. Here we report tetravalent cerium, uranium and thorium bis(carbene) complexes with trans C=M=C cores where experimental and theoretical data suggest the presence of an inverse-trans-influence. Studies of hypothetical praseodymium(IV) and terbium(IV) analogues suggest the inverse-trans-influence may extend to these ions but it also diminishes significantly as the 4f orbitals are populated. This work suggests that the inverse-trans-influence may occur beyond high oxidation state 5f metals and hence could encompass mid-range oxidation state actinides and lanthanides. Thus, the inverse-trans-influence might be a more general f-block principle.

Physics of trans-Planckian gravity

International Nuclear Information System (INIS)

Dvali, Gia; Folkerts, Sarah; Germani, Cristiano

2011-01-01

We study the field theoretical description of a generic theory of gravity flowing to Einstein general relativity in IR. We prove that, if ghost-free, in the weakly-coupled regime such a theory can never become weaker than general relativity. Using this fact, as a by-product, we suggest that in a ghost-free theory of gravity trans-Planckian propagating quantum degrees of freedom cannot exist. The only physical meaning of a trans-Planckian pole is the one of a classical state (black hole) which is described by the light IR quantum degrees of freedom and gives exponentially-suppressed contributions to virtual processes. In this picture Einstein gravity is UV self-complete, although not Wilsonian, and sub-Planckian distances are unobservable in any healthy theory of gravity. We then finally show that this UV/IR correspondence puts a severe constraint on any attempt of conventional Wilsonian UV-completion of trans-Planckian gravity. Specifically, there is no well-defined energy domain in which gravity could become asymptotically weak or safe.

Ruminant and industrial trans-fatty acid uptake in the heart.

Science.gov (United States)

Ganguly, Riya; LaVallee, Renee; Maddaford, Thane G; Devaney, Brittany; Bassett, Chantal M C; Edel, Andrea L; Pierce, Grant N

2016-05-01

Dietary trans-fats are strongly associated with heart disease. However, the capacity for the tissues of the body, and specifically the heart, to take up trans-fats is unknown. It is also unknown if different trans-fats have different uptake capacities in the heart and other tissues of the body. Diets of low-density lipoprotein receptor-deficient mice were supplemented for 14weeks with foods that contained 1.5% of the trans-fat elaidic acid or vaccenic acid. Tissues were extracted and frozen in liquid nitrogen, and then lipids were analyzed by gas chromatography for fatty acid content. Isolated cardiomyocytes were also exposed to elaidic or vaccenic acid in cell culture media for 24h. Dietary supplementation with vaccenic or elaidic acid resulted in a 20-fold higher accumulation of these TFAs in fat deposits in the body in comparison to liver. Liver tissue accumulated about twice as much per gram tissue as heart. Similar quantities of both elaidic acid and vaccenic acid were taken up by the tissues. Isolated cardiomyocytes exhibited an unusually large uptake of trans-fat, and this was dependent upon both the concentration and duration of exposure to the trans-fats but not upon the type of trans-fat. Expression levels of CD36 and FATP4 were not significantly changed during dietary interventions or exposure of cells to trans-fats. We conclude that fat, liver and heart (including cardiomyocytes) are all capable of accumulating trans-fat in response to dietary supplementation without changes in fatty acid transport protein expression. Copyright © 2016 Elsevier Inc. All rights reserved.

Trans-Spatial Utopias

Science.gov (United States)

Kramsch, Claire

2018-01-01

The "trans-" perspectives offered in this special issue are heady stuff. Post-structuralism (philosophy) meets the digital age (electronics), meets globalization (economics), and meets translingual practice (linguistics) to create a perfectly utopian or placeless space for future exploration. I want to first add my voice to the…

Writing the Past: Le Roy Ladurie and the Voice of the New History

Directory of Open Access Journals (Sweden)

Philippe Carrard

1985-09-01

Full Text Available Just as in fiction, discursive strategies in history can reveal the very nature of a project. The positivist historiography that prevailed in the late 19th and early 20th centuries regarded historical facts as givens. Accordingly, it held as its ideal of writing the objective text, that is. the text from which the historian's mediation would be carefully erased. The New History, on the other hand, considers all research to be grounded in a researcher and seeks to indicate by various means that the text does not generate itself. In Carnival in Romans , for example, Le Roy Ladurie explicitly resorts to various facets of the "I": that of the histor , going about the job of uncovering the evidence: that of the commentator, providing historical parallels and explanations; and even that of the emotional self (Barthes' personne passionnelle , making judgments on events and people in the narrative. These changes in writing conventions point to the emergence of a new historical paradigm. At the same time, they overturn the view of the historical text as a non-problematic vehicle for reporting "reality": this text, for the New Historians, becomes a construct, and is presented as such.

transPLANT Resources for Triticeae Genomic Data

Directory of Open Access Journals (Sweden)

Manuel Spannagl

2016-03-01

Full Text Available The genome sequences of many important Triticeae species, including bread wheat ( L. and barley ( L., remained uncharacterized for a long time because their high repeat content, large sizes, and polyploidy. As a result of improvements in sequencing technologies and novel analyses strategies, several of these have recently been deciphered. These efforts have generated new insights into Triticeae biology and genome organization and have important implications for downstream usage by breeders, experimental biologists, and comparative genomicists. transPLANT ( is an EU-funded project aimed at constructing hardware, software, and data infrastructure for genome-scale research in the life sciences. Since the Triticeae data are intrinsically complex, heterogenous, and distributed, the transPLANT consortium has undertaken efforts to develop common data formats and tools that enable the exchange and integration of data from distributed resources. Here we present an overview of the individual Triticeae genome resources hosted by transPLANT partners, introduce the objectives of transPLANT, and outline common developments and interfaces supporting integrated data access.

Dietary trans-fatty acids and metabolic syndrome

Directory of Open Access Journals (Sweden)

Zdzisław Kochan

2010-12-01

Full Text Available Trans-fatty acids (TFAs, products of partial hydrogenation of vegetable oils, have become more prevalent in our diet since the 1960s, when they replaced animal fats. TFAs also occur naturally in meat and dairy products from ruminants. There is growing evidence that dietary trans-fatty acids may increase the risk of metabolic syndrome. Several studies have demonstrated adverse effects of TFAs on plasma lipids and lipoproteins. In dietary trials, trans-fatty acids have been shown to raise the total cholesterol/HDL cholesterol ratio and Lp(a levels in blood. Moreover, a high intake of TFAs has been associated with an increased risk of coronary heart disease. Prospective cohort studies have shown that dietary trans-fatty acids promote abdominal obesity and weight gain. In addition, it appears that TFA consumption may be associated with the development of insulin resistance and type 2 diabetes. The documented adverse health effects of TFAs emphasise the importance of efforts to reduce the content of partially hydrogenated vegetable oils in foods.

The evolutionary landscape of intergenic trans-splicing events in insects

Science.gov (United States)

Kong, Yimeng; Zhou, Hongxia; Yu, Yao; Chen, Longxian; Hao, Pei; Li, Xuan

2015-01-01

To explore the landscape of intergenic trans-splicing events and characterize their functions and evolutionary dynamics, we conduct a mega-data study of a phylogeny containing eight species across five orders of class Insecta, a model system spanning 400 million years of evolution. A total of 1,627 trans-splicing events involving 2,199 genes are identified, accounting for 1.58% of the total genes. Homology analysis reveals that mod(mdg4)-like trans-splicing is the only conserved event that is consistently observed in multiple species across two orders, which represents a unique case of functional diversification involving trans-splicing. Thus, evolutionarily its potential for generating proteins with novel function is not broadly utilized by insects. Furthermore, 146 non-mod trans-spliced transcripts are found to resemble canonical genes from different species. Trans-splicing preserving the function of ‘breakup' genes may serve as a general mechanism for relaxing the constraints on gene structure, with profound implications for the evolution of genes and genomes. PMID:26521696

READING COLONIZATION IN CONRAD'S TRANS-RACIAL LOVE PLOTS

Directory of Open Access Journals (Sweden)

Sandra Lilyana

2017-07-01

Full Text Available The study is about a close look at Conrad's trans-racial romance related to the Victorian period. Trans-racial love between white men and non-white women becomes a popular theme in the early works of Josep Conrad, a famous writer of the late Victorian period. Using a closely technical reading in the three of Conrad's works Lord Jim, Almayer's Folly, and An Outcast of the Island, we can show that such a trans-racial romance is not merely meant for appreciating equivalence. In turn, the trans-racial romance of Conrad's can be understood as the reflection of the Western colonization on the East where the white men take a role as subjects who had dominately explored while the non-white women as objects who are passively being explored. Key words: colonization, race, romance plot, subject, object, and dominance

Technical aspects of trans reduction in margarines

Directory of Open Access Journals (Sweden)

Van Duijn Gerrit

2000-01-01

Full Text Available The opinion of nutritional science on the effect of trans fatty acids on blood cholesterol has drastically changed during the last decade. As a reaction to these new findings, the European margarine industry decided in the mid nineties to eliminate trans containing components from their margarine fat phase compositions. This excluded practically the use of partially hydrogenated oils and fats. Trans-free margarines have been introduced with optimised fat crystal structures stabilising a maximum of water in oil emulsion with a minimum of solid fat phase. These fat crystal structures are formed by fat phase components obtained from interesterification and/or fractionation of non-hydrogenated and/or fully hydrogenated feedstocks.

High-performance marketing: an interview with Nike's Phil Knight. Interview by Geraldine E. Willigan.

Science.gov (United States)

Knight, P

1992-01-01

Nike's advertising slogans--"Bo Knows," "Just Do It," and "There Is No Finish Line"--have moved beyond advertising into popular expression. Its athletic footwear and clothing have become a piece of Americana. Its brand name is as well known around the world as IBM and Coke. Behind the slogans and the flashy TV commercials is the vision of its founder, chairman, and CEO, Phil Knight. Since forming the company in 1962, Knight has taken Nike from a small-time distributor of Japanese track shoes to the top of the athletic shoe and apparel market. But not without a stumble. Along the way, Knight discovered that technological innovation alone could not continue to drive growth. When sales stagnated in the mid-1980s, Knight and Nike learned several hard lessons on how to build brands and understand consumers, and they transformed their technology company into a marketing company whose product is its most important marketing tool. "Ultimately," says Knight, "we wanted Nike to be the world's best sports and fitness company. Once you say that, you have a focus. You don't end up making wing tips or sponsoring the next Rolling Stones world tour." To keep the company growing, Nike began splitting its brands into sub-brands. In tennis, Nike divided its shoes into Challenge Court--for younger, more active players--and Supreme Court--for older, more mature players. That approach brought the company to a broader range of consumers while preserving the customer base. And to create an emotional tie with the consumer, Nike started advertising on TV. "Sports is at the heart of American culture," Knight says. "You can't explain much in 60 seconds, but when you show Michael Jordan, you don't have to. It's that simple."

ANALYSIS ON THE TRANSLATION OF WORDPLAYS IN “THE GOD OF SMALL THINGS” BY ARUNDHATI ROY (Studies on the Wordplay Shifts and the Translation Quality

Directory of Open Access Journals (Sweden)

Nur Saptaningsih

2017-04-01

Full Text Available Wordplay commonly appears in literary works to enrich the works themselves with certain effect and nuance, either to make a joke or to conceal anything taboo. However, problems frequently occur in translation of wordplay and this becomes an obstacle for a translator to find proper equivalent. Moreover, the translation of wordplay is closely related to different language systems (source and target languages. Novel of ―The God of Small Things‖ by Arundhati Roy is rich in the use of wordplays, but there are a number of shifts found in the translated version of the wordplays. This paper deals with descriptivequalitative research aiming at investigating the shifts of wordplays in the novel of ―The God of Small Things‖ by Arundhati Roy and in the translated version. This study also highlights the contribution of the shifts on the translation quality, in terms of accuracy and acceptability. This product-oriented study applies embedded-case method. The first data for this research are documents, consisting of source text and the translated text. The other data are obtained from informants (raters and respondents, consisting of information dealing with accuracy and acceptability. The data are collected using document analyses, questionnaire, and interview. Purposive sampling and content analysis are applied.

Unscripting Curriculum: Toward a Critical Trans Pedagogy

Science.gov (United States)

Keenan, Harper Benjamin

2017-01-01

In this essay, Harper B. Keenan draws on his own experience as a white queer and trans educator to consider the meaning of a critical trans pedagogy. Amid dissonant narratives of equal rights and subjection, he explores how his classroom teaching is shaped by his own experience of gender conditioning as well as by the contemporary political…

Relative Stability of cis- and trans-Hydrindanones

Directory of Open Access Journals (Sweden)

Motoo Tori

2015-01-01

Full Text Available The relative stabilities of several cis- and trans-hydrindanones were compared using both isomerization experiments and MM2 calculations. The generally believed rule that cis-hydrindanones are more stable than trans-isomers is applicable, but is not always true. This review introduces examples, mainly from studies in our laboratory, to explain these facts.

Structural modification of trans-cinnamic acid using Colletotrichum acutatum

OpenAIRE

Velasco B., Rodrigo; Gil G., Jesús H.; García P., Carlos M.; Durango R., Diego L.

2012-01-01

The biotransformation of trans-cinnamic acid by whole cells of the Colombian native phytopathogenic fungus Colletotrichum acutatum was studied. Initially, fungitoxicity of this compound against C. acutatum was evaluated; trans-cinnamic acid exhibited a moderate to weak toxicity against the microorganism and apparently a detoxification mechanism was present. Then, in order to study such mechanism and explore the capacity of this fungus to biotransform trans-cinnamic acid into value-added produ...

2,3-trans-3,4-trans-3,4-Dihydroxy-L-proline: An amino acid in toxic peptides of Amanita virosa mushrooms

Science.gov (United States)

Buku, A.; Faulstich, H.; Wieland, T.; Dabrowski, J.

1980-01-01

Among the four possible stereoisomers of 3,4-dihydroxy-L-proline,2,3-trans-3,4-trans-3,4-dihydroxy-L-proline (IV) had not been found in nature previously. It has now been detected as a component of virotoxins, toxic peptides of Amanita virosa mushrooms. Because periodate failed to effect an oxidative glycol splitting reaction, the two hydroxyl groups in positions 3 and 4 were expected to be in a trans configuration. Furthermore, the formation of a 4-lactone on treatment with acids pointed to the carboxyl group and the hydroxyl group at position 4 being in a cis configuration. These results are in agreement with structure IV only. Final proof for structure IV was given by NMR spectroscopy and direct comparison with the 2,3-cis-3,4-trans-3,4-dihydroxy-L-proline isomer. PMID:16592813

Epicuro e o tema da amizade: a philía vinculada ao érôs da tradição e ao êthos cívico da pólis

Directory of Open Access Journals (Sweden)

Miguel Spinelli

2011-06-01

Full Text Available Central to the so-called ethical doctrine of Epicurus, the theme of friendship in this paper is analyzed under three aspects: a in regards to its link to the traditional principles (the so-called golden rule with which several cultures have sought to govern friendly relations; b how Epicurus, in a sense different from that of Plato’s Academy took to the Garden the practice of philía as a test for reconstituting the pólis; c how the concept of utility (the opheleía is linked to interest and reciprocity.

TransPlanckian Particles and the Quantization of Time

NARCIS (Netherlands)

Hooft, G. 't

1999-01-01

Trans-Planckian particles are elementary particles accelerated such that their energies surpass the Planck value. There are several reasons to believe that trans-Planckian particles do not represent independent degrees of freedom in Hilbert space, but they are controlled by the cis-Planckian

Low Trans Hydrogenation

Science.gov (United States)

Although hydrogenation has been the technology of choice for fat formulation for many years recent concerns over the health and nutrition of trans fatty acids have had a profound effect on the edible oil industry. Since Jan. 1, 2006, TFA has been required on nutrition labels along with saturated an...

Perfil nutricional de alimentos com alegação de zero gordura trans Nutritional profile of foods with zero trans fatty acids claim

Directory of Open Access Journals (Sweden)

Ana Carolina Moron Gagliardi

2009-01-01

Full Text Available OBJETIVO: Avaliar a composição de ácidos graxos de alguns alimentos industrializados disponíveis no mercado brasileiro nos quais houve redução da quantidade de ácidos graxos trans. Verificar também se estes alimentos atendem às quantidades recomendadas de consumo de gordura saturada, após redução de gordura trans. MÉTODOS: Alimentos industrializados (margarina cremosa A e B, margarina com fitosterol, biscoito doce recheado, biscoito salgado sem recheio, batata frita e lanche com hambúrguer de fast food multinacional com alegação de 0% de gordura trans foram adquiridos em pontos comerciais e analisados em cromatógrafo gasoso. RESULTADOS: Apesar da redução nas quantidades de ácidos graxos trans, os alimentos analisados contêm grandes quantidades de gorduras saturadas principalmente o ácido palmítico. Além disso, alguns dos alimentos estudados apresentam uma razão n-3/n-6 fora do recomendado para a prevenção da aterosclerose. CONCLUSÃO: O consumo irrestrito desses alimentos tem forte potencial deletério para a saúde. O rótulo de ausência de ácidos graxos trans deve ser visto com cuidado e não significa uma liberação para o consumo irrestrito desses alimentos.OBJECTIVE: To evaluate the composition of fatty acids in some foods available in the Brazilian market in which there was a claimed reduction in the amount of trans fatty acids. Also evaluate whether these foods meet recommended amounts for saturated fat consumption, after reduction of trans fat amounts. METHODS: Industrialized food (creamy margarine A and B, plant sterol margarine, stuffed sweet biscuit, salty biscuit without stuffing, French fried potatoes and a burger lunch from a multinational chain of "fast food" all with the allegation of 0% trans fat content were purchased in commercial points and analyzed by gas chromatography. RESULTS: Despite the reduction in trans fatty acid amounts, analyzed foods contained large concentrations of saturated fats

Crise hipertensiva: estudo de caso com utilização da classificação das intervenções de enfermagem para alcançar respostas adaptativas baseadas no Modelo Teórico de Roy Crisis hipertensiva: estudio de caso con utilización de la clasificación de las intervenciones de enfermería para alcanzar respuestas adaptativas basadas en el Modelo Teórico de Roy Hypertensive crisis: case study with use of the nursing interventions classification in order to reach adaptive responses based in the Roy’s Theoretic Model

Directory of Open Access Journals (Sweden)

Maria Vilaní Cavalcante Guedes

2005-09-01

Full Text Available INTRODUÇÃO: Por acreditarmos que as complicações da hipertensão arterial surgem em decorrência da falta de adaptação do cliente à doença e ao tratamento, neste estudo trabalharemos com o modelo conceitual de enfermagem proposto por Roy e Andrews, conhecido como Modelo de Adaptação, na tentativa de descobrir meios de cuidar destas pessoas, ajudando-as a se manterem adaptadas e integradas. OBJETIVO: Este trabalho objetivou descrever as intervenções de enfermagem coerentes com a situação de crise hipertensiva, com apoio na Classificação das Intervenções de Enfermagem (NIC, buscando a interface com o Modelo de Adaptação de Roy. MÉTODO: Trata-se de pesquisa tipo estudo de caso realizada com cliente em crise hipertensiva atendida em um serviço especializado em hipertensão e diabetes em Fortaleza, no período de setembro a novembro de 2003, com dados coletados no serviço e no domicílio da cliente. RESULTADOS: Como apontam os resultados, existem dificuldades adaptativas em todos os modos. Por isto, as intervenções de enfermagem selecionadas da NIC foram implementadas com o apoio da família. CONCLUSÃO: Conclui-se ser viável a abordagem de cliente tendo por base os conceitos do Modelo Adaptativo de Roy e as intervenções de enfermagem da referida classificação.INTRODUCCIÓN: Por creermos que las complicaciones de la hipertensión arterial en decurrencia de la falta de adaptación del cliente a la enfermedad y al tratamiento, trabajaremos en este trabajo con el modelo conceptual de enfermería propuesto por Roy y Andrews, conocido como Modelo de Adaptación, intentando descubrir medios de cuidar de estas personas, ayudándolas a se manteneren adaptadas e integradas. OBJETIVO: Este trabajo ha objetivado describir las intervenciones de enfermería coherentes con la situación de crisis de hipertensión, con apoyo en la Clasificación de las Intervenciones de Enfermería (NIC, buscando la interfaz con el Modelo de Adaptaci

Design of Trypanosoma rangeli sialidase mutants with improved trans-sialidase activity.

Directory of Open Access Journals (Sweden)

Christian Nyffenegger

Full Text Available A sialidase (EC 3.2.1.18 from the non-pathogenic Trypanosoma rangeli, TrSA, has been shown to exert trans-sialidase activity after mutation of five specific amino acids in the active site (M96V, A98P, S120Y, G249Y, Q284P to form the so-called TrSA5mut enzyme. By computational and hypothesis driven approaches additional mutations enhancing the trans-sialidase activity have been suggested. In the present work, we made a systematic combination of these mutations leading to seven new variants of the T. rangeli sialidase, having 6-16 targeted amino acid mutations. The resulting enzyme variants were analyzed via kinetics for their ability to carry out trans-sialidase reaction using CGMP and D-lactose as substrates. The sialidase variants with 15 and 16 mutations, respectively, exhibited significantly improved trans-sialidase activity for D-lactose sialylation. Our results corroborate, that computational studies of trans-glycosylation can be a valuable input in the design of novel trans-glycosidases, but also highlight the importance of experimental validation in order to assess the performance. In conclusion, two of the seven mutants displayed a dramatic switch in specificity from hydrolysis towards trans-sialylation and constitute the most potent trans-sialidase mutants of TrSA described in literature to date.

Coupling of dimethylsulfide oxidation to biomass production by a marine flavobacterium

Digital Repository Service at National Institute of Oceanography (India)

Green, D.H.; Shenoy, D.M.; Hart, M.C.; Hatton, A.D.

. Stirling, and J. R. Quayle. 1982. Co-metabolism [and discussion]. Phil Trans R Soc Lond B 297:481-496. 7. del Valle, D. A., D. J. Kieber, and R. P. Kiene. 2007. Depth-dependent fate of biologically- consumed dimethylsulfide in the Sargasso Sea. Mar Chem.... Klenk. 1985. Measurement of protein using bicinchoninic acid. Anal Biochem 150:76-85. 27. Vila-Costa, M., D. A. del Valle, J. M. Gonzalez, D. Slezak, R. P. Kiene, O. Sanchez, and R. Simo. 2006. Phylogenetic identification and metabolism of marine...

Interesterificação química: alternativa para obtenção de gorduras zero trans Chemical interresterification: alternative to production of zero trans fats

Directory of Open Access Journals (Sweden)

Ana Paula Badan Ribeiro

2007-10-01

Full Text Available The function of lipids in human nutrition has been intensively debated in the last decade.This context reinforces the concern about controlling the trans fat ingestion, due to its negative implications on health. Interesterification provides an important alternative to modify the consistency of oils and fats without causing formation of trans isomers. This article reports research done towards production of zero trans fats by chemical interesterification, for different industrial purposes. Aspects related to the effect of trans fats on diet, their impact on health and modifications in Brazilian legislation are also covered.

Trans-dinitroglycoluril isomers-A DFT treatment

Directory of Open Access Journals (Sweden)

Lemi Türker

2017-02-01

Full Text Available Isomers of trans-1,4-Dinitroglycoluril (trans-DINGU and their 1,3-tautomers are considered within the constraints of B3LYP/6-31++G (d,p and B3LYP/CC-PVTZ levels of DFT calculations. Additionally, the interactions of these isomers and proton in vacuum are investigated. The data have revealed that two of the three isomers undergo CH bond cleavage as the result of interaction with proton in vacuum. The total energies, some structural properties, the calculated IR and UV spectra are discussed.

Aplicación del Modelo de Adaptación de Callista Roy en Latinoamérica: revisión de la literatura

OpenAIRE

María Elisa Moreno-Fergusson; Alejandra María Alvarado-García

2009-01-01

Con el propósito de conocer los avances en la aplicación del Modelo de Adaptación de Callista Roy en Latinoamérica, se realizó una revisión de la literatura en el período comprendido entre 1996 y 2009. De los 163 documentos encontrados, se seleccionaron 45, que los autores clasificaron en siete categorías, según el propósito de los estudios. Los resultados señalan que el Modelo ha sido aplicado principalmente en Brasil, México y Colombia. La mayoría de los estudios reportados son de tipo desc...

A simplified study of trans-mitral Doppler patterns

Directory of Open Access Journals (Sweden)

Thomas George

2008-11-01

Full Text Available Abstract Background Trans-mitral Doppler produces complex patterns with a great deal of variability. There are several confusing numerical measures and indices to study these patterns. However trans-mitral Doppler produces readymade data visualization by pattern generation which could be interpreted by pattern analysis. By following a systematic approach we could create an order and use this tool to study cardiac function. Presentation of the hypothesis In this new approach we eliminate the variables and apply pattern recognition as the main criterion of study. Proper terminologies are also devised to avoid confusion. In this way we can get some meaningful information. Testing the hypothesis Trans-mitral Doppler should be seen as patterns rather than the amplitude. The hypothesis can be proven by logical deduction, extrapolation and elimination of variables. Trans-mitral flow is also analyzed vis-à-vis the Starling's Law applied to the left atrium. Implications of the hypothesis Trans-mitral Doppler patterns are not just useful for evaluating diastolic function. They are also useful to evaluate systolic function. By following this schema we could get useful diagnostic information and therapeutic options using simple pattern recognition with minimal measurements. This simplified but practical approach will be useful in day to day clinical practice and help in understanding cardiac function better. This will also standardize research and improve communication.

Trans-sphenoidal excision of craniopharyngiomas.

Directory of Open Access Journals (Sweden)

Nagpal R

1991-04-01

Full Text Available Craniopharyngiomas have been by and large excised by the transcranial route. Since 1982, 11 patients have been operated by the traus-sphensidal route in the department. The clinical features with which they were presented, diagnostic investigations, details of surgical procedures and follow-up analysis is being presented here. A retrospective study of radiological investigation was done to determine the features that help decide the choice of surgical approach to these lesions. Only lesions that were primarily intrasellar, cystic and those that expanded the sella could be treated by the trans-sphenoidal route. Associated suprasellar extensions could also be removed. Predominantly calcified or firm, fleshy tumours lent themselves poorly to removal by the trans-sphenoidal route.

TransAlta Corporation 1996 annual report : new directions, new opportunities

International Nuclear Information System (INIS)

Anon.

1997-01-01

TransAlta Corp. is an energy management company that operates through two subsidiaries: (1) TransAlta Utilities Corp. which owns and operates electricity generation, transmission and distribution assets in Alberta, and (2) TransAlta Energy Corp. which is in the business of electric and thermal energy supply, gas and electricity distribution, energy services and energy marketing in regions of Canada, New Zealand, Australia, Argentina and the United States. This report presents a summary of operations, and provides consolidated financial statements and common share information for 1996. During the year the corporation advanced three significant initiatives (1) operational effectiveness, as shown by impressive productivity increases, and major investments in three independent power projects, (2) improved strategic direction through a review of plans and options, resulting in a clearer, more focused vision of the future, and (3) realignment of the organizational structure by centralizing marketing and sales functions, and establishing a corporate business development group. Details of operational and financial results were provided for both subsidiaries, i. e. TransAlta Utilities and TransAlta Energy. Sales of electric energy for TransAlta Utilities amounted to 27.8 billion kWh; 4.6 billion kWh for TransAlta Energy. Return on equity was 11.4 per cent, down from 11.8 per cent in 1995. Net earnings per common share were $1.14 per share (including one-time items), the same as in 1995. tabs., figs

Biscoitos recheados: quanto mais baratos maior teor de gordura trans? = Filled cookies: the cheaper the higher trans fat content?

Directory of Open Access Journals (Sweden)

Galdino, Tatiana Pizzato

2010-01-01

Conclusões: quanto maior a quantidade de gorduras trans, menor a quantidade de gordura saturada e menor preço. Sugere-se uma revisão na legislação quanto à inserção da quantidade exata de gorduras trans no rótulo, uma vez que o consumo elevado dessas gorduras está associado a dislipidemias, um fator de risco para doença cardiovascular

Mapping Discrimination Experienced by Indonesian Trans* FtM Persons.

Science.gov (United States)

Gordon, Danny; Pratama, Mario Prajna

2017-01-01

This work sought to document how Indonesian trans* FtM persons experienced discrimination across the interlinked domains of social networks, religious and educational institutions, employment and the workplace, and health care institutions. Objectives were (1) to map the discrimination experienced by trans* FtM individuals in Indonesia, and (2) to establish the specific priorities of the Indonesian trans* FtM community. In-depth interviews, focus groups, and participant observation was used involving 14 respondents. Findings revealed that respondents experienced othering through rejection, misidentification, harassment, "correction," and bureaucratic discrimination across the five preestablished domains. Health care and a lack of information emerged as areas of particular concern for respondents. This work calls for health care that is sensitive to the needs of trans* FtM people coupled with high-quality information to alleviate the cycles through which discrimination is sustained.

Assistência de enfermagem a idosos que realizam cateterismo cardíaco: uma proposta a partir do modelo de adaptação de Calista Roy Asistencia de enfermería a ancianos que realizan cateterismo cardíaco: una propuesta a partir del modelo de adaptación de Calista Roy Nursing care to elderly patients undergoing heart catheterization: a proposal according to the Adaptation model of Calista Roy

Directory of Open Access Journals (Sweden)

Maria Célia de Freitas

2006-10-01

Full Text Available O estudo objetivou identificar os diagnósticos de enfermagem de idosos que realizam cateterismo cardíaco, abordando os aspectos psicossociais, segundo a Teoria de Adaptação de Roy. Desenvolveu-se em hospital de pronto-atendimento em cardiologia de Fortaleza-CE, de janeiro a julho de 2005. Utilizou-se entrevista semi-estruturada, com 18 idosos de ambos os sexos, no pré-cateterismo. Na análise reconheceram-se os diagnósticos: alteração na manutenção da saúde, ansiedade, medo e alteração no processo familiar. Como intervenções propõe-se: criar um clima de confiança, antes do exame; escutar e respeitar sentimentos, crenças e valores, orientar quanto ao procedimento. A utilização desta teoria permitiu reconhecer que as pessoas, mediante estímulos, podem desencadear respostas positivas ou negativas, cabendo ao enfermeiro atuar como mediador.El estúdio objetivó identificar los diagnósticos de enfermería abordando los aspectos psico-sociales de los pacientes que realizan cateterismo cardiaco, según la Teoría de Adaptación de Roy. Se desarrolló en la sección de cardiología de un hospital de Fortaleza-CE, de Janeiro a Julio de 2005. Se utilizó la entrevista semi-estructurada, con 18 ancianos, en el pre-cateterismo. En el análisis reconocieron los diagnósticos: alteración en la manutención de la salud, ansiedad, miedo y alteración en el proceso familiar. Entre las acciones se elaboraron las siguientes: crearse un clima de confianza para el paciente después del examen; escuchar y respetar sentimientos, creencias y valores referentes a la situación; orientar el paciente cuanto al procedimiento. La utilización de esta teoría permitió reconocer que las personas, mediante estímulos, pueden desencadenar respuestas ora positivas ora negativas, cabiendo al enfermero actuar como mediador.The study aimed at identifying the nursing diagnoses related to the psychological and social aspects of elderly patients undergoing

Evolution of cichlid vision via trans-regulatory divergence

Directory of Open Access Journals (Sweden)

O’Quin Kelly E

2012-12-01

Full Text Available Abstract Background Phenotypic evolution may occur through mutations that affect either the structure or expression of protein-coding genes. Although the evolution of color vision has historically been attributed to structural mutations within the opsin genes, recent research has shown that opsin regulatory mutations can also tune photoreceptor sensitivity and color vision. Visual sensitivity in African cichlid fishes varies as a result of the differential expression of seven opsin genes. We crossed cichlid species that express different opsin gene sets and scanned their genome for expression Quantitative Trait Loci (eQTL responsible for these differences. Our results shed light on the role that different structural, cis-, and trans-regulatory mutations play in the evolution of color vision. Results We identified 11 eQTL that contribute to the divergent expression of five opsin genes. On three linkage groups, several eQTL formed regulatory “hotspots” associated with the expression of multiple opsins. Importantly, however, the majority of the eQTL we identified (8/11 or 73% occur on linkage groups located trans to the opsin genes, suggesting that cichlid color vision has evolved primarily via trans-regulatory divergence. By modeling the impact of just two of these trans-regulatory eQTL, we show that opsin regulatory mutations can alter cichlid photoreceptor sensitivity and color vision at least as much as opsin structural mutations can. Conclusions Combined with previous work, we demonstrate that the evolution of cichlid color vision results from the interplay of structural, cis-, and especially trans-regulatory loci. Although there are numerous examples of structural and cis-regulatory mutations that contribute to phenotypic evolution, our results suggest that trans-regulatory mutations could contribute to phenotypic divergence more commonly than previously expected, especially in systems like color vision, where compensatory changes in the

Effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid (CLA) isomers on immune function in healthy men

NARCIS (Netherlands)

Albers, R.; Wielen, R.P.J. van der; Brink, E.J.; Hendriks, H.F.J.; Dorovska-Taran, V.N.; Mohede, I.C.M.

2003-01-01

Objectives: To study the effects of two different mixtures of the main conjugated linoleic acid (CLA) isomers cis-9, trans-11 CLA and trans-10, cis-12 CLA on human immune function. Design: Double-blind, randomized, parallel, reference-controlled intervention study. Subjects and intervention:

Structural modification of trans-cinnamic acid using Colletotrichum acutatum

OpenAIRE

Rodrigo Velasco B.; Jesús H. Gil G.; Carlos M. García P.; Diego L. Durango R.

2012-01-01

Se estudió la biotransformación de ácido trans-cinámico mediante células completas del hongo fitopatógeno nativo colombiano Colletotrichum acutatum. Inicialmente, se evaluó la fungitoxicidad de este compuesto contraC. acutatum; el ácido trans-cinámico exhibió una toxicidad moderada a débil contra el microorganismo y aparentemente se presentó un mecanismo de detoxificación. Luego, para estudiar tal mecanismo y explorar la capacidad de este hongo para biotransformar el ácido trans-cinámico en ...

She's always a woman: Butch lesbian trans women in the lesbian community.

Science.gov (United States)

Rossiter, Hannah

2016-01-01

While the visibility and acceptance of trans women have grown globally in recent years, this progress has primarily been within a traditional, heteronormative narrative. But a growing number of trans women identify as butch lesbians and challenge this heteronormative narrative. The existence of butch trans women has created a debate on where they fit within queer and lesbian communities and how their gender performance fits within traditional butch/femme understandings of lesbian or queer relationships. This article seeks to explore the intersections of gender identity and sexual orientation that butch trans women experience when they engage with lesbian and trans communities.

Trans-jugular catheter-directed thrombolysis combined with trans-dorsalis pedis vein thrombolysis for the treatment of deep venous thrombosis of the lower limbs

International Nuclear Information System (INIS)

Qian Jiesheng; Li Zhengran; Jiang Zaibo; Zhu Kangshun; Guan Shouhai; Zhou Bing; Xu Changmou; He Keke; Shang Hong

2009-01-01

Objective: To investigate the feasibility and efficacy of trans-jugular catheter-directed thrombolysis (CDT) together with trans-dorsalis pedis vein thrombolysis for the treatment of deep venous thrombosis (DVT) of the lower limbs. Methods: Jugular vein puncture, indwelling catheter and placement of IVC filter were performed in 18 patients with DVT (study group) followed by continuous trans-jugular CDT together with trans-dorsalis pedis vein thrombolysis. During the corresponding period, 16 patients with DVT (control group) received trans-dorsalis pedis vein thrombolysis only. Results: The thrombolytic time and total dose of urokinase in study group and control group were (6.6 ± 2.3) days, (5.52 ± 2.24) x 106 units and (8.2 ± 1.4) days, (7.00 ± 1.66) x 106 units respectively. The thrombolytic time and total dose of urokinase in study group were significantly lower than that in control group (P < 0.05). After the treatment the thigh circumference and calf circumference in study group showed a reduction of (4.6 ± 2.1) cm and (4.0 ± 2.1) cm respectively, which were (3.2 ± 1.7) cm and (2.7 ± 1.5) cm respectively in control group, the difference between two groups was statistically significant (P < 0.05). The complete patent of the veins was 66.7% in study group and 31.3% in control group, the difference between two groups was significant (P < 0.05). In four cases of the study group, the filters were withdrawn through the original puncture site after the thrombus was completely dissolved. Conclusion: Trans-jugular CDT combined with trans-dorsalis pedis vein thrombolysis is an effective and safe therapeutic technique for the treatment of deep venous thrombosis of the lower extremities, moreover, the filter can be taken back via the original puncture site when the thrombus is completely dissolved. (authors)

Design of Trypanosoma rangeli sialidase mutants with improved trans-sialidase activity

DEFF Research Database (Denmark)

Nyffenegger, Christian; Nordvang, Rune Thorbjørn; Jers, Carsten

2017-01-01

were analyzed via kinetics for their ability to carry out trans-sialidase reaction using CGMP and D-lactose as substrates. The sialidase variants with 15 and 16 mutations, respectively, exhibited significantly improved trans-sialidase activity for D-lactose sialylation. Our results corroborate......, that computational studies of trans-glycosylation can be a valuable input in the design of novel trans-glycosidases, but also highlight the importance of experimental validation in order to assess the performance. In conclusion, two of the seven mutants displayed a dramatic switch in specificity from hydrolysis...

Teores de ácidos graxos trans de alguns alimentos consumidos no Rio de Janeiro Trans fatty acids of some foods consumed in Rio de Janeiro, Brazil

Directory of Open Access Journals (Sweden)

Vera Lúcia Chiara

2003-06-01

Full Text Available Desconhecem-se os teores de ácidos graxos trans em diversos alimentos. Este estudo analisou os teores de ácidos graxos trans, saturados, monoinsaturados e poliinsaturados em batatas fritas, biscoitos e sorvetes. As batatas fritas foram dos tipos chips e de duas redes de fast food, os sorvetes, de duas marcas comerciais e de duas lojas de fast food, e os biscoitos, de marcas diferentes. As amostras de batatas chips e de biscoitos pertenciam a lotes distintos e foram adquiridas em supermercados da região. Analisaram-se seis amostras por produto, através de cromatografia gasosa. O valor médio dos ácidos trans de batatas fritas de redes de fast food foi de 4,74g/100g, enquanto em batatas chips estes ácidos graxos não foram detectados. Nos sorvetes os valores variaram de 0,041g a 1,41g e em biscoitos, de 2,81g a 5,60g. Biscoitos tipo cream cracker apresentaram teores de ácidos graxos trans mais altos e de insaturados mais baixos. Concluiu-se que alguns produtos apresentaram, em 100g, teores de ácidos graxos trans superiores aos recomendados para ingestão total diária em diversos países.The content of trans fatty acids in most consumed foods in Brazil is unknown. This study assessed trans saturated, monounsaturated and polyunsaturated fatty acids in samples of fried potatoes, cookies and ice cream. The analysis included: potato chips and fried potatoes from two popular fast food restaurants, ice cream of two different trademarks and from two fast food restaurants, and cookies of different trademarks. The samples of potato chips and cookies were acquired in different supermarkets in the city of Rio de Janeiro, and distinct manufacture dates were chosen. Six samples of each product were analyzed through gas chromatography. The average trans fatty acids content in fried potatoes from fast food restaurants was 4.74g/100g; in ice cream the values varied from 0.041g to 1.41g; and in cookies the values varied from 2.81g to 5.60g. No trans fatty

Biochemical characterization of trans-sialidase TS1 variants from Trypanosoma congolense

Directory of Open Access Journals (Sweden)

Dietz Frank

2011-07-01

Full Text Available Abstract Background Animal African trypanosomiasis, sleeping sickness in humans and Nagana in cattle, is a resurgent disease in Africa caused by Trypanosoma parasites. Trans-sialidases expressed by trypanosomes play an important role in the infection cycle of insects and mammals. Whereas trans-sialidases of other trypanosomes like the American T. cruzi are well investigated, relatively little research has been done on these enzymes of T. congolense. Results Based on a partial sequence and an open reading frame in the WTSI database, DNA sequences encoding for eleven T. congolense trans-sialidase 1 variants with 96.3% overall amino acid identity were amplified. Trans-sialidase 1 variants were expressed as recombinant proteins, isolated and assayed for trans-sialylation activity. The purified proteins produced α2,3-sialyllactose from lactose by desialylating fetuin, clearly demonstrating their trans-sialidase activity. Using an HPLC-based assay, substrate specificities and kinetic parameters of two variants were characterized in detail indicating differences in substrate specificities for lactose, fetuin and synthetic substrates. Both enzymes were able to sialylate asialofetuin to an extent, which was sufficient to reconstitute binding sites for Siglec-4. A mass spectrometric analysis of the sialylation pattern of glycopeptides from fetuin revealed clear but generally similar changes in the sialylation pattern of the N-glycans on fetuin catalyzed by the trans-sialidases investigated. Conclusions The identification and characterization of a trans-sialidase gene family of the African parasite T. congolense has opened new perspectives for investigating the biological role of these enzymes in Nagana and sleeping sickness. Based on this study it will be interesting to address the expression pattern of these genes and their activities in the different stages of the parasite in its infection cycle. Furthermore, these trans-sialidases have the

Formation of trans-caffeoyl-CoA from trans-4-coumaroyl-CoA by Zn2+-dependent enzymes in cultured plant cells and its activation by an elicitor-induced pH shift

NARCIS (Netherlands)

Kneusel, R.; Matern, U.; Nicolaij, K.

1989-01-01

A novel hydroxylase activity catalyzing the formation of trans-caffeoyl-CoA from trans-4-coumaroyl-CoA was identified in crude extracts from cultured parsley cells. The extracts were less active (Vmax/Km) in converting trans-4-coumaric to trans-caffeic acid. Optimal hydroxylase activity was found at

Trans-kingdom cross-talk

DEFF Research Database (Denmark)

Knip, Marijn; Constantin, Maria-Ermioni; Thordal-Christensen, Hans

2014-01-01

This review focuses on the mobility of small RNA (sRNA) molecules from the perspective of trans-kingdom gene silencing. Mobility of sRNA molecules within organisms is a well-known phenomenon, facilitating gene silencing between cells and tissues. sRNA signals are also transmitted between organism...

A trans world journey

DEFF Research Database (Denmark)

Stender, Steen; Dyerberg, Jørn; Bysted, Anette

2006-01-01

to a maximum of 2% of fat content from 2004. We assessed the potential exposure of consumers to IP-TFA by analysing popular foods in Denmark, and in 25 other countries. Fifty-five servings of French fries and chicken nuggets, 87 packages of microwave popcorn, and 393 samples of biscuits....../cakes/wafers with "partially hydrogenated vegetable fat" listed high on the food label were bought between November 2004, and February 2006. The content of IP-TFA was analysed by standardized methodology. We defined a "high trans menu" as a large size serving of French fries and nuggets, 100 g of microwave popcorn, and 100 g......A high intake of industrially produced trans fatty acids (IP-TFA) is associated with increased risk of coronary heart disease (CHD), and a daily intake as low as possible is required to minimize health risks. To achieve this at the individual level in Denmark, legislation limited IP-TFA in foods...

Regional Cooperation Towards Trans-country Natural Gas Market

DEFF Research Database (Denmark)

Shukla, P.R.; Dhar, Subash

2009-01-01

India began gas imports since 2004 through liquified natural gas (LNG) route. Imports through trans-country gas pipelines could help in bringing gas directly into the densely populated Northern part of India, which are far from domestic gas resources as well as coastal LNG terminals. The purpose ...... of this paper is to report scenarios, which quantify the impacts for India of regional cooperation to materialize trans-country pipelines. The analysis covers time period from 2005 to 2030.......India began gas imports since 2004 through liquified natural gas (LNG) route. Imports through trans-country gas pipelines could help in bringing gas directly into the densely populated Northern part of India, which are far from domestic gas resources as well as coastal LNG terminals. The purpose...

Thiyl radical-induced cis-trans-isomerization of arachidonic acid inhibits prostaglandin metabolism

International Nuclear Information System (INIS)

Kratzsch, S.; Droessler, K.; Sprinz, H.; Brede, O.

2002-01-01

Complete text of publication follows. Thiyl radicals radiolytically generated from thiophenol in methanolic solution are known to isomerise double bonds of poly-unsaturated fatty acids (PUFA). γ-irradiating of such a system containing all-cis 5,8,11,14 eicosatetraenoic acid (arachidonic acid, AA) with low doses (0.1-0.8 kGy) results in a mixture of 8 to 32% mono-trans-isomers. Here we report about the influence of mono-trans-AA on the primary steps of AA-metabolism and prostaglandin synthesis, catalysed by cyclooxygenase (COX). In the cell-free model system the reaction of COX-1 with AA was analysed by controlling the oxygen level during the enzymatic reaction. As an example, a mixture of a low quantity of mono-trans-isomerized AA (10%) and 90% all-cis-isomer exhibits a marked reduced oxygen consumption by 45%. As further proofs - the yield of reactive oxygen species (ROS) generated by the COX-coupled peroxidase reaction was detected, - and the COX-1 activity in presence of different amounts of trans-AA was characterized using a photometric assay based on the oxidation of TMPD. All these methods indicated semiquantitatively a reduced activity of COX-1, depending on the trans-isomer yield. Therefore, an inhibition of COX-1 activity by only one trans-double-bond in AA could be concluded. Furthermore, in vitro cell-line experiments were performed analysing the influence of mono-trans-isomerized AA on the activity of the cell-own COX-2. Hence, VD 3 -differentiated and LPS-stimulated monocyte-like cells were incubated with mono-trans-AA and ROS-production was detected by the chemiluminescence measurements mentioned above. Compared to the reaction with all-cis-AA we found a considerable lowered formation of ROS. Likewise, we obtained a reduced PGE 2 -expression between 15 and 40% for cells treated with 8 to 29% trans-AA. The model as well as in vivo experiments demonstrate an inhibition effect of mono-trans-AA and give rise for postulating an enzyme blocking mechanism

Disintegration of aerobic granules induced by trans-2-decenoic acid.

Science.gov (United States)

Cai, Pei-Jie; Xiao, Xiang; He, Yan-Rong; Li, Wen-Wei; Yu, Lei; Yu, Han-Qing

2013-01-01

One current major hurdle to practical implementation of aerobic granule technology is the frequent occurrence of granule disintegration during long-term operation. However, the mechanism behind this is largely unclear today. Here, 2-decenoic acid, which has been previously demonstrated to be released by Pseudomonas aeruginosa and disperse biofilms, was found to also induce the disintegration of aerobic granules. A comparison of the solution compositions from samples of only trans-2-decenoic acid, only aerobic granules, and granules added with trans-2-decenoic acid shows that bacteria and extracellular polymeric substances (EPS) were stripped from granule surface upon trans-2-decenoic acid dosing. Due to the possible toxicity of trans-2-decenoic acid at a saturation concentration, the disintegrated granules and the milky suspension in the disintegration test showed a significantly lower oxygen uptake rate than the un-integrated granules. This work suggests that trans-2-decenoic acid released by microbes might play a critical role in regulating the disintegration of aerobic granules. Copyright © 2012 Elsevier Ltd. All rights reserved.

EFECTIVIDAD DEL PROGRAMA EDUCATIVO: “ADOPTANDO UNA DIETA SALUDABLE” BASADA EN ROY EN PREESCOLARES DE LA INSTITUCIÓN EDUCATIVA: “UN NUEVO MUNDO”. PIMENTEL- 2014

OpenAIRE

Chirinos Fernández, Jennifer Melissa; Universidad Señor de Sipán; Rodríguez Cabrejos, Iris Janet; Universidad Señor de Sípán

2015-01-01

 El estudio de tipo cuantitativo tuvo como objetivo determinar la efectividad del programa educativo: Adoptando una dieta saludable basada en Callista Roy en preescolares de la I.E. Un nuevo mundo. El diseño fue cuasi experimental. La población fue no probabilística siendo 60 personas, la muestra fue a conveniencia, distribuyéndose en 2 grupos de 20 preescolares, control y experimental respectivamente. El instrumento utilizado fue el Cuestionario de Valoración Nutricional por dimensiones segú...

Shifting Paradigms: Moving beyond "Trans 101" in Sexuality Education

Science.gov (United States)

Green, Eli R.

2010-01-01

Trans-inclusive sexuality education can be complex, confusing, and outright intimidating for even the most seasoned sexuality educator to teach. Historically, standalone "Trans 101" sessions have successfully raised awareness about the highly marginalized transgender community. However, their potential success has been limited by being taught in…

Illela border market: origin and contributions to trans-border ...

African Journals Online (AJOL)

Illela border market: origin and contributions to trans-border relations between Nigeria and Niger republic. ... cordial relations between her and her immediate neighbours and thus stem the scourge of smuggling and other trans-border crimes which have negatively affected the Nigerian economy and her international image.

Genetic variation within three populations of Phycella australis (Phil. Ravenna from Biobío Region, Chile, evaluated using ISSR markers

Directory of Open Access Journals (Sweden)

Cristian Flores

2013-03-01

Full Text Available Phycella australis (Phil. Ravenna is a Chilean plant with high ornamental potential; however, the intensive extraction as a cut flower might be detrimental for the conservational state by ignoring the state of genetic variation. The objective of this investigation was to assess genetic variability within and between three populations of P. australis in the Biobío Region using inter-simple sequence repeat (ISSR markers. The evaluated areas correspond to three locations in the province of Concepción, Biobío Region: Desembocadura (36°48' S, 73°10' W, Santa Juana (36°58' S, 72°58' W, and Lipinhue (37°00' S, 72°58' W. Six ISSR primers were used obtaining 51 fragments, from which 72.5% were polymorphic. From the three evaluated sites Santa Juana showed a higher percentage of polymorphic loci (76.47%. From this variability, 83% belong to within population variability and only 17% belong to variability between populations. The dendrogram generated using the unweighted pair group method with arithmetic mean (UPGMA method, grouped Lipinhue and Santa Juana sites together, which agrees with the geographic locations. This investigation proved that P. australis has high genetic variability despite the exploitation for economic purposes.

Metabolism of all-trans-retinoic acid and all-trans-retinyl acetate. Demonstration of common physiological metabolites in rat small intestinal mucosa and circulation

International Nuclear Information System (INIS)

Cullum, M.E.; Zile, M.H.

1985-01-01

The kinetics and metabolism of physiological doses of all-trans-retinoic acid were examined in blood and small intestinal mucosa of vitamin A-depleted rats. A major portion of intrajugularly injected retinoic acid is rapidly (within 2 min) sequestered by tissues; subsequently 13-cis-retinoic acid and polar metabolites are released into circulation. All-trans-retinoic acid appears in small intestinal epithelium within 2 min after dosing and is the major radioactive compound there for at least 2 h. Retinoyl glucuronide and 13-cis-retinoic acid are early metabolites of all-trans-retinoic acid in the small intestine of bile duct-cannulated rats. Retinoyl glucuronide, the major metabolite of retinoic acid intestinal epithelium, in contrast to other polar metabolites, was not detected in circulation. An examination of [ 3 H]retinyl acetate metabolites under steady state conditions in vitamin A-repleted rats demonstrates the occurrence of all-trans-retinoic acid and 13-cis-retinoic acid in circulation and in intestinal epithelium, in a pattern similar to that found after injection of retinoic acid into vitamin A-depleted rats. These data establish that all-trans-retinoic acid, 13-cis-retinoic acid, and retinoyl glucuronide are physiological metabolites of vitamin A in target tissues, and therefore are important candidates as mediators of the biological effect of the vitamin

Reprogramming the Dynamin 2 mRNA by Spliceosome-mediated RNA Trans-splicing

Directory of Open Access Journals (Sweden)

Delphine Trochet

2016-01-01

Full Text Available Dynamin 2 (DNM2 is a large GTPase, ubiquitously expressed, involved in membrane trafficking and regulation of actin and microtubule cytoskeletons. DNM2 mutations cause autosomal dominant centronuclear myopathy which is a rare congenital myopathy characterized by skeletal muscle weakness and histopathological features including nuclear centralization in absence of regeneration. No curative treatment is currently available for the DNM2-related autosomal dominant centronuclear myopathy. In order to develop therapeutic strategy, we evaluated here the potential of Spliceosome-Mediated RNA Trans-splicing technology to reprogram the Dnm2-mRNA in vitro and in vivo in mice. We show that classical 3′-trans-splicing strategy cannot be considered as accurate therapeutic strategy regarding toxicity of the pre-trans-splicing molecules leading to low rate of trans-splicing in vivo. Thus, we tested alternative strategies devoted to prevent this toxicity and enhance frequency of trans-splicing events. We succeeded to overcome the toxicity through a 5′-trans-splicing strategy which also allows detection of trans-splicing events at mRNA and protein levels in vitro and in vivo. These results suggest that the Spliceosome-Mediated RNA Trans-splicing strategy may be used to reprogram mutated Dnm2-mRNA but highlight the potential toxicity linked to the molecular tools which have to be carefully investigated during preclinical development.

Trans-dissemination of exosomes from HIV-1-infected cells fosters both HIV-1 trans-infection in resting CD4+ T lymphocytes and reactivation of the HIV-1 reservoir.

Science.gov (United States)

Chiozzini, Chiara; Arenaccio, Claudia; Olivetta, Eleonora; Anticoli, Simona; Manfredi, Francesco; Ferrantelli, Flavia; d'Ettorre, Gabriella; Schietroma, Ivan; Andreotti, Mauro; Federico, Maurizio

2017-09-01

Intact HIV-1 and exosomes can be internalized by dendritic cells (DCs) through a common pathway leading to their transmission to CD4 + T lymphocytes by means of mechanisms defined as trans-infection and trans-dissemination, respectively. We previously reported that exosomes from HIV-1-infected cells activate both uninfected quiescent CD4 + T lymphocytes, which become permissive to HIV-1, and latently infected cells, with release of HIV-1 particles. However, nothing is known about the effects of trans-dissemination of exosomes produced by HIV-1-infected cells on uninfected or latently HIV-1-infected CD4 + T lymphocytes. Here, we report that trans-dissemination of exosomes from HIV-1-infected cells induces cell activation in resting CD4 + T lymphocytes, which appears stronger with mature than immature DCs. Using purified preparations of both HIV-1 and exosomes, we observed that mDC-mediated trans-dissemination of exosomes from HIV-1-infected cells to resting CD4 + T lymphocytes induces efficient trans-infection and HIV-1 expression in target cells. Most relevant, when both mDCs and CD4 + T lymphocytes were isolated from combination anti-retroviral therapy (ART)-treated HIV-1-infected patients, trans-dissemination of exosomes from HIV-1-infected cells led to HIV-1 reactivation from the viral reservoir. In sum, our data suggest a role of exosome trans-dissemination in both HIV-1 spread in the infected host and reactivation of the HIV-1 reservoir.

After runaway: The trans-Hill stage of planetesimal growth

International Nuclear Information System (INIS)

Lithwick, Yoram

2014-01-01

When planetesimals begin to grow by coagulation, they first enter an epoch of runaway, during which the biggest bodies grow faster than all the others. The questions of how runaway ends and what comes next have not been answered satisfactorily. We show that runaway is followed by a new stage—the 'trans-Hill stage'—that commences when the bodies that dominate viscous stirring ('big bodies') become trans-Hill, i.e., when their Hill velocity matches the random speed of the small bodies they accrete. Subsequently, the small bodies' random speed grows in lockstep with the big bodies' sizes, such that the system remains in the trans-Hill state. Trans-Hill growth is crucial for determining the efficiency of growing big bodies, as well as their growth timescale and size spectrum. Trans-Hill growth has two sub-stages. In the earlier one, which occurs while the stirring bodies remain sufficiently small, the evolution is collisionless, i.e., collisional cooling among all bodies is irrelevant. The efficiency of forming big bodies in this collisionless sub-stage is very low, ∼10α << 1, where α ∼ 0.005(a/AU) –1 is the ratio between the physical size of a body and its Hill radius. Furthermore, the size spectrum is flat (equal mass per size decade, i.e., q = 4). This collisionless trans-Hill solution explains results from previous coagulation simulations for both the Kuiper Belt and the asteroid belt. The second trans-Hill sub-stage commences once the stirring bodies grow big enough (>α –1 × the size of the accreted small bodies). After that time, collisional cooling among small bodies controls the evolution. The efficiency of forming big bodies rises and the size spectrum becomes more top heavy. Trans-Hill growth can terminate in one of two ways, depending on the sizes of the small bodies. First, mutual accretion of big bodies can become significant and conglomeration proceeds until half of the total mass is converted into big bodies

Monoclonal antibodies to DNA modified with cis- or trans-diamminedichloroplatinum(II)

International Nuclear Information System (INIS)

Sundquist, W.I.; Lippard, S.J.; Stollar, B.D.

1987-01-01

Murine monoclonal antibodies that bind selectively to adducts formed on DNA by the antitumor drug cis-diamminedichloroplatinum(II), cis-DDP, or to the chemothrapeutically inactive trans isomer trans-DDP were elicited by immunization with calf thymus DNA modified with either cis- or trans-DDP at ratios of bound platinum per nucleotide, (D/N)/sub b/, of 0.06-0.08. The binding of two monoclonal antibodies to cis-DDP-modified DNA was competitively inhibited in an enzyme-linked immunosorbent assay (ELISA) by 4-6 nM concentrations of cis-DDP bound to DNA. Adducts formed by cis-DDP on other synthetic DNA polymers did not inhibit antibody binding to cis-DDP-DNA. The biologically active compounds [Pt(en)Cl 2 ], [Pt(dach)Cl 2 ], and [Pt(NH 3 ) 2 (cbdca)] (carboplatin) all formed antibody-detectable adducts on DNA, whereas the inactive platinum complexes trans-DDP and [Pt(dien)Cl]Cl (dien, diethylenetriamine) did not. The monoclonal antibodies therefore recognize a bifunctional Pt-DNA adduct with cis stereochemistry in which platinum is coordinated by two adjacent guanines or, to a lesser degree, by adjacent adenine and guanine. A monoclonal antibody raised against trans-DDP-DNA was competitively inhibited in an ELISA by 40 nM trans-DDP bound to DNA. This antibody crossreacted with unmodified, denatured DNA. The recognition of cis- or trans-DDP-modified DNAs by monoclonal antibodies thus parallels the known modes of DNA binding of these compounds and may correlate with their biological activities

Transparent and Stretchable High-Performance Supercapacitors Based on Wrinkled Graphene Electrodes

Science.gov (United States)

2013-12-18

2, 870–875. 38. Chen, T.; Dai, L. Carbon Nanomaterials for High- Performance Supercapacitors . Mater. Today 2013, 16, 272–280. 39. Stoller, M. D...High-Performance Supercapacitors Based onWrinkledGraphene Electrodes Tao Chen,† Yuhua Xue,† Ajit K. Roy,‡ and Liming Dai†,* †Center of Advanced Science...electrodes and the associated supercapacitor cells cannot be both trans- parent and stretchable.1318 It is highly desirable to integrate the

Trans people's experiences with assisted reproduction services: a qualitative study.

Science.gov (United States)

James-Abra, S; Tarasoff, L A; Green, D; Epstein, R; Anderson, S; Marvel, S; Steele, L S; Ross, L E

2015-06-01

What are the experiences of trans persons (i.e. those whose gender identity does not match the gender assigned to them at birth) who sought or accessed assisted reproduction (AR) services in Ontario, Canada, between 2007 and 2010? The majority of trans persons report negative experiences with AR service providers. Apart from research examining desire to have children among trans people, most of the literature on this topic has debated the ethics of assisting trans persons to become parents. To-date, all of the published research concerning trans persons' experiences with AR services is solely from the perspective of service providers; no studies have examined the experiences of trans people themselves. Secondary qualitative research study of data from nine trans-identified people and their partners (total n = 11) collected as part of a community-based study of access to AR services for sexual and gender minority people between 2010 and 2012. Trans-identified volunteers (and their partners, when applicable) who had used or attempted to access AR services since 2007 from across Ontario, Canada, participated in a 60-90 minute, semi-structured qualitative interview. Qualitative analysis was performed using a descriptive phenomenological approach. Emerging themes were continually checked against the data as part of an iterative process. The data highlight barriers to accessing AR services for trans people. Participant recommendations for improving AR service provision to better meet the needs of this population are presented. These recommendations address the following areas: (i) AR service provider education and training; (ii) service provider and clinic practices and (iii) clinic environment. The majority of study participants were trans people who identified as men and who resided in major urban areas; those living in smaller communities may have different experiences that were not adequately captured in this analysis. While existing literature debates the ethics of

The importance of trans-generational effects in Lepidoptera

OpenAIRE

Woestmann, Luisa; Saastamoinen, Marjo

2016-01-01

The importance of trans-generational effects in shaping an individuals' phenotype and fitness, and consequently even impacting population dynamics is increasingly apparent. Most of the research on trans-generational effects still focuses on plants, mammals, and birds. In the past few years, however, increasing number of studies, especially on maternal effects, have highlighted their importance also in many insect systems. Lepidoptera, specifically butterflies, have been used as model systems ...

Science and trans-science in standard setting

International Nuclear Information System (INIS)

Majone, G.

1984-01-01

Standard-setting is a blending of scientific, trans-scientific, and political elements which result in a number of consequences. Health standards, for example, are influenced by biological and philosophical assumptions and scientific traditions, with the dose-response function treated as a trans-scientific question because of scientific uncertainties. Costs and benefits and other values besides health, safety, or environment also enter into the balancing of regulatory decisions and keep regulations from a purely scientific knowledge is desirable. Recommendations that industry be self-regulatory reflect a shift in emphasis from legal enforcement to information-based compliance

TransAlta 2003 annual report

International Nuclear Information System (INIS)

2004-01-01

This annual report presents financial information from TransAlta Corp., along with a review of its operations throughout 2003 and a summary of the how the electric utility has performed in terms of power generation, independent power producers, transmission and energy marketing. TransAlta is one of the largest non-regulated power generation and wholesale marketing companies in Canada. It's assets include coal-fired, gas-fired, hydro and renewable generation facilities in Canada, the United States, Mexico and Australia. Reported earnings in 2003 were $1.26 per share compared to $1.17 in 2002. The strong first quarter was followed by harsh market conditions, low water levels which affected hydro production, and pricing restrictions in Ontario that reduced contribution from the Sarnia plant. This report outlines the utility's progress in increasing revenue and producing more power. In 2003, unplanned outages were reduced by 7 per cent and injury frequency rate was reduced by 27 per cent. The installation of 114 wind turbines in Fort Macleod, Alberta, increased TransAlta's renewable energy capacity to 3.7 per cent in 2003. The wind farm produces 75 MW of electricity, enough to power more than 32,500 homes annually. This report summarized the company's energy resource activities and presented an operations review as well as consolidated financial statements and common share information. This included the utility's assets, liabilities, revenues, expenses and cash flows. Revenue and expenditure statements were summarized by source. refs., tabs., figs

Strange Bedfellows: Anachronisms, Identity Politics, and the Queer Case of Trans.

Science.gov (United States)

Gailey, Nerissa

2017-01-01

This article explores trans identities, as articulated within a few historical texts. From early literary depictions of gender difference, to medicalized conceptions of transsexualism, to a proliferation of trans and queer identities represented by an ever-expanding "alphabet soup" of identity labels, our understandings of identities, sexualities, and queer community-building continue to change. I use the notion of "kind-making," as elaborated on in the work of Ian Hacking, to illustrate that some queer and trans identifications are affiliative, whereas others are contrastive or oppositional in nature, and these structural differences have important implications with respect to understanding identity and sexuality, and also trans inclusion within LGBT communities and activist efforts.

Differential effect of corn oil-based low trans structured fat on the plasma and hepatic lipid profile in an atherogenic mouse model: comparison to hydrogenated trans fat

Directory of Open Access Journals (Sweden)

Kim Hye-Jin

2011-01-01

Full Text Available Abstract Background Trans fat are not desirable in many aspects on health maintenance. Low trans structured fats have been reported to be relatively more safe than trans fats. Methods We examined the effects of low trans structured fat from corn oil (LC, compared with high trans fat shortening, on cholesterol and fatty acid metabolism in apo E deficient mice which is an atherogenic animal model. The animals were fed a high trans fat (10% fat: commercial shortening (CS or a low trans fat (LC diet for 12 weeks. Results LC decreased apo B and hepatic cholesterol and triglyceride concentration compared to the CS group but significantly increased plasma total cholesterol and triglyceride concentration and fecal lipids with a simultaneous increase in HDL-cholesterol level, apo A-I, and the ratio of HDL-cholesterol to total cholesterol (HTR. Reduction of hepatic lipid levels by inclusion of LC intake was observed alongside modulation of hepatic enzyme activities related to cholesterol esterification, fatty acid metabolism and fecal lipids level compared to the CS group. The differential effects of LC intake on the plasma and hepatic lipid profile seemed to be partly due to the fatty acid composition of LC which contains higher MUFA, PUFA and SFA content as well as lower content of trans fatty acids compared to CS. Conclusions We suggest that LC may exert a dual effect on plasma and hepatic lipid metabolism in an atherogenic animal model. Accordingly, LC, supplemented at 10% in diet, had an anti-atherogenic effect on these apo E-/- mice, and increased fecal lipids, decreased hepatic steatosis, but elevated plasma lipids. Further studies are needed to verify the exact mode of action regarding the complex physiological changes and alteration in lipid metabolism caused by LC.

Differential effect of corn oil-based low trans structured fat on the plasma and hepatic lipid profile in an atherogenic mouse model: comparison to hydrogenated trans fat

Science.gov (United States)

2011-01-01

Background Trans fat are not desirable in many aspects on health maintenance. Low trans structured fats have been reported to be relatively more safe than trans fats. Methods We examined the effects of low trans structured fat from corn oil (LC), compared with high trans fat shortening, on cholesterol and fatty acid metabolism in apo E deficient mice which is an atherogenic animal model. The animals were fed a high trans fat (10% fat: commercial shortening (CS)) or a low trans fat (LC) diet for 12 weeks. Results LC decreased apo B and hepatic cholesterol and triglyceride concentration compared to the CS group but significantly increased plasma total cholesterol and triglyceride concentration and fecal lipids with a simultaneous increase in HDL-cholesterol level, apo A-I, and the ratio of HDL-cholesterol to total cholesterol (HTR). Reduction of hepatic lipid levels by inclusion of LC intake was observed alongside modulation of hepatic enzyme activities related to cholesterol esterification, fatty acid metabolism and fecal lipids level compared to the CS group. The differential effects of LC intake on the plasma and hepatic lipid profile seemed to be partly due to the fatty acid composition of LC which contains higher MUFA, PUFA and SFA content as well as lower content of trans fatty acids compared to CS. Conclusions We suggest that LC may exert a dual effect on plasma and hepatic lipid metabolism in an atherogenic animal model. Accordingly, LC, supplemented at 10% in diet, had an anti-atherogenic effect on these apo E-/- mice, and increased fecal lipids, decreased hepatic steatosis, but elevated plasma lipids. Further studies are needed to verify the exact mode of action regarding the complex physiological changes and alteration in lipid metabolism caused by LC. PMID:21247503

Trans*Forming College Masculinities: Carving out Trans*Masculine Pathways through the Threshold of Dominance

Science.gov (United States)

Jourian, T. J.

2017-01-01

Men and masculinities studies are gaining prominence in higher education literature, illuminating how cisgender college men understand and grapple with masculinity. Additionally, the increased visibility of trans* students has fueled the expanding scholarship and attention to their experiences, often however centering on white gender-conforming…

Mechanically induced cis to trans reisomerization of azobenzene

Science.gov (United States)

Turansky, Robert; Konopka, Martin; Stich, Ivan; Marx, Dominik

2007-03-01

Using density functional techniques we study mechanochemistry of the azobenzene molecule. Azobenzene is an optically switchable molecule. Laser light is normally used to achieve molecular switching between the cis and trans isomers. We use mechanochemistry to achieve the switching. Thiolate-gold bond can used to exert mechanical energy on the molecule bonded between two gold electrodes in static AFM apparatus. Our model consists of two realistic gold electrodes bridged by dithioazobenzene. We find that pulling the transisomer leads just to formation of gold nanowires and mechanical breakage of the electrodes. However, mechanochemistry with modest applied forces leads to cis trans reisomerization via rotation mechanism. Contrary, use of simple constraints instead of realistic gold electrodes, leads to cis trans reisomerization, albeit with significantly larger applied forces and via inversion mechanism. Important experimental and theoretical ramifications of these simulations will be discussed.

It All Starts with a Sandwich: Identification of Sialidases with Trans-Glycosylation Activity

DEFF Research Database (Denmark)

Nordvang, Rune Thorbjørn; Nyffenegger, Christian; Holck, Jesper

2016-01-01

structure of two amino acids proximal to the active site of the T. cruzi trans-sialidase infers trans-sialidase activity. On this basis, four enzymes with putative trans-sialidase activity were identified through an iterative alignment from 2909 native sialidases available in GenBank, which were cloned...... and expressed in Escherichia coli. Of these, one enzyme, SialH, derived from Haemophilus parasuis had an aromatic sandwich structure on the protein surface facing the end of the catalytic site (Phe168; Trp366), and was indeed found to exhibit trans-sialidase activity. SialH catalyzed production of the human...... provided data that help understand structure-function relations of trans-sialidases....

Siegel discs via trans-quasiconformal surgery

DEFF Research Database (Denmark)

Petersen, Carsten Lunde

2014-01-01

kompleksstruktur kan integreres, det vil sige definerer en kompleksstruktur. I denne komplekse struktur er den nye afbildning holomorf og har en Siegel disk. Der findes imidlertid masser af tilfælde hvor dette ikke lader sig gøre, men hvor man istedet kan finde en trans-kvasikonform udvidelse til enheds-disken af...... mængde af rotationstal med fuldt mål på cirklen har konjugationen en trans-kvasi-konform udvidelse til disken. Dette er et skridt i beviset for at for næsten alle (i Lebeguemåls forstand) rotations tal, er randen af Siegel-disken for et kvadratisk polynomium med en Siegel disk med et sådant rotationstal...

Endoscopic treatment of trans-sellar trans-sphenoidal encephalocele associated with morning glory syndrome presenting with non-traumatic cerebrospinal fluid rhinorrhea.

Science.gov (United States)

Sasani, M; Ozer, A F; Aydin, A L

2009-03-01

Basal encephaloceles are rare, accounting for about 1.5% of all encephaloceles. The trans-sellar trans-sphenoidal encephalocele variety is the rarest. Morning glory syndrome is often associated with basal encephalocele. Spontaneous cerebrospinal fluid (CSF) rhinorrheas are the least common of these, accounting for only 3% to 5% of all CSF rhinorrheas. The authors describe the outcome of a 10-year follow-up study of a 26-year-old male patient with a spontaneous CSF rhinorrhea occurring trans-sphenoidal encephalocele associated with bilateral morning glory syndrome that was treated with an endoscopic endonasal approach. Endoscopic exploration of the sella floor was performed and closed with abdomen fat packing and muscle fascia. The postoperative course was uneventful. A follow-up magnetic resonance (MR) image at 6 months postoperatively showed extension of encephalocele in the sphenoidal sinus, which was repaired. The patient had no further CSF rhinorrhea and showed no ophthalmologic changes over a follow-up period of over 10 years. Ophthalmologic findings such as strabismus, in association with anomalies of the optic nerve, should alert the physician to the possible presence of an unrecognized skull base midline defect and encephalocele before CSF leakage is seen. The authors believe that a surgeon who has equal confidence in performing the endoscopic endonasal and conventional microscopic trans-sphenoidal approaches should choose the less invasive surgery.

Reprogramming Acyl Carrier Protein Interactions of an Acyl-CoA Promiscuous trans-Acyltransferase

DEFF Research Database (Denmark)

Ye, Zhixia; Musiol-Kroll, Ewa Maria; Weber, Tilmann

2014-01-01

Protein interactions between acyl carrier proteins (ACPs) and trans-acting acyltransferase domains (trans-ATs) are critical for regioselective extender unit installation by many polyketide synthases, yet little is known regarding the specificity of these interactions, particularly for trans-ATs w...

The TransPetro emergency response system

Energy Technology Data Exchange (ETDEWEB)

Filho, A.T.F.; Cardoso, V.F.; Carbone, R.; Berardinelli, R.P. [Petrobras-TransPetro, Rio de Janeiro (Brazil); Carvalho, M.T.M.; Casanova, M.A. [Pontificia Univ. Catolica, Rio de Janeiro (Brazil). Dept. de Informatica, TeCGraf

2004-07-01

Petrobras-TransPetro developed the TransPetro Emergency Response System in response to emergency situations at large oil pipelines or at terminal facilities located in sea or river harbour areas. The standard of excellence includes full compliance with environmental regulations set by the federal government. A distributed workflow management software called InfoPAE forms the basis of the system in which actions are defined, along with geographic and conventional data. The first prototype of InfoPAE was installed in 1999. Currently it is operational in nearly 80 installations. The basic concepts and functionality of the TransPetro Emergency Response System were outlined in this paper with reference to the mitigative actions that are based on an evaluation of the organization of the emergency teams; the communication procedures; characterization of the installations; definition of accidental scenarios; environmental sensitivity maps; simulation of oil spill trajectories and dispersion behaviour; geographical data of the area surrounding the installations; and, other conventional data related to the installations, including available equipment. The emergency response team can take action as soon as an accident is detected. The action plan involves characterizing several scenarios and delegating mitigative actions to specific sub-teams, each with access to geographic data on the region where the emergency occurred. 13 refs., 3 figs.

Stream traffic data archival, querying, and analysis with TransDec.

Science.gov (United States)

2011-01-01

The goal of research was to extend the traffic data analysis of the TransDec (short for : Transportation Decision-Making) system, which was developed under METRANS 09-26 : research grant. The TransDec system is a real-data driven system to support de...

Antioxidant capacity of trans-resveratrol dietary supplements alone or combined with the mycotoxin beauvericin.

Science.gov (United States)

Mallebrera, Beatriz; Maietti, Annalisa; Tedeschi, Paola; Font, Guillermina; Ruiz, Maria-Jose; Brandolini, Vincenzo

2017-07-01

Trans-resveratrol (trans-RSV) is a polyphenol with multiples biological properties, such as anti-inflammatory, antioxidant, anti-aging, anti-diabetic, and antiplatelet. It occurs naturally in grapes and derivate, peanuts and berries. Beauvericin (BEA) is a mycotoxin present in cereals that produces cytotoxicity, intracellular reactive oxygen species and lipid peroxidation. The general objective of this research was to evaluate whether trans-RSV could be used as a good polyphenol against damages produced by BEA. Because trans-RSV can be ingested through dietary supplements, to reach this goal, the following specific objectives were proposed: to determine a) the trans-RSV content in different polyphenol dietary supplements by capillary electrophoresis, b) the antioxidant capacity of the trans-RSV in polyphenol supplements, and c) the influence of BEA in the antioxidant capacity of trans-RSV when they are in combination by photochemioluminiscence assay. The results obtained in this study showed that all polyphenol dietary supplements present higher RSV content that the content of the label. The polyphenol supplements present antioxidant capacity. And the combination of trans-RSV and BEA did not affect the antioxidant capacity of trans-RSV. Thus, RSV could contribute to decrease oxidant effects produced by BEA. Copyright © 2017 Elsevier Ltd. All rights reserved.

Trans Fat Intake and Its Dietary Sources in General Populations Worldwide: A Systematic Review

Science.gov (United States)

Wanders, Anne J.; Zock, Peter L.; Brouwer, Ingeborg A.

2017-01-01

After the discovery that trans fat increases the risk of coronary heart disease, trans fat content of foods have considerably changed. The aim of this study was to systematically review available data on intakes of trans fat and its dietary sources in general populations worldwide. Data from national dietary surveys and population studies published from 1995 onward were searched via Scopus and websites of national public health institutes. Relevant data from 29 countries were identified. The most up to date estimates of total trans fat intake ranged from 0.3 to 4.2 percent of total energy intake (En%) across countries. Seven countries had trans fat intakes higher than the World Health Organization recommendation of 1 En%. In 16 out of 21 countries with data on dietary sources, intakes of trans fat from animal sources were higher than that from industrial sources. Time trend data from 20 countries showed substantial declines in industrial trans fat intake since 1995. In conclusion, nowadays, in the majority of countries for which data are available, average trans fat intake is lower than the recommended maximum intake of 1 En%, with intakes from animal sources being higher than from industrial sources. In the past 20 years, substantial reductions in industrial trans fat have been achieved in many countries. PMID:28783062

Perfil de ácidos graxos trans de óleo e gordura hidrogenada de soja no processo de fritura Fatty acids trans profile of oil and hidrogenated soy fat in frying process

Directory of Open Access Journals (Sweden)

Elaine Abrão Assef Sanibal

2004-03-01

Full Text Available O objetivo desse estudo foi avaliar as alterações dos ácidos graxos e a formação de isômeros trans, durante o aquecimento de óleo de soja (OS e gordura parcialmente hidrogenada de soja (GPHS no processo de fritura de batata por 100 horas com reposição lipídica. O perfil de ácidos graxos foi avaliado através de cromatografia gasosa em coluna capilar de 100m. Os ácidos graxos monoinsaturados trans foram os predominantes entre os isômeros trans. A partir de 10 horas de fritura, o OS formou 2,1% de isômeros mono trans e ao final de 50 horas este valor passou a 14,3% contra uma diminuição do total de ácidos graxos poliinsaturados, que passou de 59,9% antes do processamento para 32,6% após 50h de fritura. Entretanto, a GPHS apresentou 20,2% de ácidos graxos mono trans antes de ser submetida à fritura e após 50 horas apresentou uma concentração de 28%. Houve também, uma diminuição do total de ácidos graxos essenciais séries ômega6 e ômega3, de 12,8% para 7,3% no mesmo período. Os resultados obtidos revelaram que isômeros trans são formados no óleo e na gordura durante o processo de fritura, sendo que a formação de isômeros trans, ocorreu em menor proporção na GPHS, confirmando a sua maior estabilidade em relação ao OS. Estes resultados indicam a importância de se identificar os ácidos graxos trans nos óleos e gorduras ulizadas em processos de fritura.The objective of this study, was to examine the alterations of the fatty acids profile and the formation of trans fatty acids isomers during heating of soy oil (SO and partially hydrogenated soy fat (PHSF in the process of french frying. The fatty acids profile was examined by gas chromatography with a 100m capillary column. The fatty acids trans monounsaturated were the predominant among trans isomers. The isomers trans monounsaturated corresponded to 2.1% of the total, after 10 hours of frying, and 14.3% after 50h - frying. Poliunsaturated fatty acids

Study of reactions of isotopic exchange of trans-zeatin with tritium

International Nuclear Information System (INIS)

Sidorov, G.V.; Myasoedov, N.F.

2006-01-01

Reactions of isotopic exchange of trans-zeatin with high-radioactive tritium water, with gaseous tritium in solution and solid-phase catalytic hydrogenation are studied to prepare trans-zeatin and dihydrozeatin labelled with tritium. It is shown that reaction of isotopic exchange of trans-zeatin with gaseous tritium both in solutions and without solvents at 160 Deg C and above leads to practically total hydrogenation of initial compound with formation of dihydrozeatin labelled with tritium. Isotopic exchange with tritium water permits to prepare zeatin labelled with tritium with 67 % yield and specific radioactivity 0.68 PBq/mol. It is determined that in the case of solid-phase isotopic exchange within 150-155 Deg C temperature interval both dihydrozeatin and trans-zeatin labelled with tritium are formed [ru

Trans-African Identity: Cultural Globalization and the Role of the ...

African Journals Online (AJOL)

Globalization entails a process, in any case irreversible, of intensification of transnational, trans-societal and trans-cultural spaces, events, problems, economic transactions, conflicts and biographies, a process not necessarily unfolding in a centripetal, homogeneous and single way towards the formation of a single world ...

Trans Ova Genetics, L.C. - Clean Water Act Public Notice

Science.gov (United States)

The EPA is providing notice of a proposed Administrative Penalty Assessment against Trans Ova Genetics, L.C., a business located at 2938 380th Street Sioux Center, IA 51250, for alleged violations at the Trans Ova Genetics, L.C.’s facility located in 12425

Genders and Individual Treatment Progress in (Non-)Binary Trans Individuals.

Science.gov (United States)

Koehler, Andreas; Eyssel, Jana; Nieder, Timo O

2018-01-01

Health care for transgender and transsexual (ie, trans) individuals has long been based on a binary understanding of gender (ie, feminine vs masculine). However, the existence of non-binary or genderqueer (NBGQ) genders is increasingly recognized by academic and/or health care professionals. To gain insight into the individual health care experiences and needs of binary and NBGQ individuals to improve their health care outcomes and experience. Data were collected using an online survey study on experiences with trans health care. The non-clinical sample consisted of 415 trans individuals. An individual treatment progress score was calculated to report and compare participants' individual progress toward treatment completion and consider the individual treatment needs and definitions of completed treatment (ie, amount and types of different treatments needed to complete one's medical transition). Main outcome measures were (i) general and trans-related sociodemographic data and (ii) received and planned treatments. Participants reported binary (81.7%) and different NBGQ (18.3%) genders. The 2 groups differed significantly in basic demographic data (eg, mean age; P < .05). NBGQ participants reported significantly fewer received treatments compared with binary participants. For planned treatments, binary participants reported more treatments related to primary sex characteristics only. Binary participants required more treatments for a completed treatment than NBGQ participants (6.0 vs 4.0). There were no differences with regard to individual treatment progress score. Because traditional binary-focused treatment practice could have hindered NBGQ individuals from accessing trans health care or sufficiently articulating their needs, health care professionals are encouraged to provide a holistic and individual treatment approach and acknowledge genders outside the gender binary to address their needs appropriately. Because the study was made inclusive for non

Ruminant and industrially produced trans fatty acids

DEFF Research Database (Denmark)

Stender, Steen; Astrup, Arne; Dyerberg, Jørn

2008-01-01

% of the fatty acids in trans form compared to the content in ruminant fat which generally does not exceed 6%. In Western Europe, including Scandinavia, the average daily intake of IP-TFA has decreased during the recent decade due to societal pressure and a legislative ban, whereas the intake of RP-TFA has......Fatty acids of trans configuration in our food come from two different sources - industrially produced partially hydrogenated fat (IP-TFA) used in frying oils, margarines, spreads, and in bakery products, and ruminant fat in dairy and meat products (RP-TFA). The first source may contain up to 60...

In Search of a Trans-national Climate Change Law

International Nuclear Information System (INIS)

Lassus Saint-Genies, Geraud de

2016-01-01

Private entities engagement in the battle against climate change is a well-established fact, and a source of intense and diversified normative activity. A certain type of climate rules has thus arisen, with a private origin and an international scope, as they transcend the borders of existing territories. In this context, one could wonder about the possible existence of a trans-national climate change law, as a relatively autonomous body of law, which would exist at the margins of international and national climate change law. Building on the discussions that have been conducted about the trans-national law in other areas of regulations, this study intends to provide answers about the possible existence of a trans-national climate change law

Trans Fat Intake and Its Dietary Sources in General Populations Worldwide: A Systematic Review

Directory of Open Access Journals (Sweden)

Anne J. Wanders

2017-08-01

Full Text Available After the discovery that trans fat increases the risk of coronary heart disease, trans fat content of foods have considerably changed. The aim of this study was to systematically review available data on intakes of trans fat and its dietary sources in general populations worldwide. Data from national dietary surveys and population studies published from 1995 onward were searched via Scopus and websites of national public health institutes. Relevant data from 29 countries were identified. The most up to date estimates of total trans fat intake ranged from 0.3 to 4.2 percent of total energy intake (En% across countries. Seven countries had trans fat intakes higher than the World Health Organization recommendation of 1 En%. In 16 out of 21 countries with data on dietary sources, intakes of trans fat from animal sources were higher than that from industrial sources. Time trend data from 20 countries showed substantial declines in industrial trans fat intake since 1995. In conclusion, nowadays, in the majority of countries for which data are available, average trans fat intake is lower than the recommended maximum intake of 1 En%, with intakes from animal sources being higher than from industrial sources. In the past 20 years, substantial reductions in industrial trans fat have been achieved in many countries.

Biscoitos recheados: quanto mais baratos maior teor de gordura trans? = Filled cookies: the cheaper the higher trans fat content?

OpenAIRE

Galdino, Tatiana Pizzato

2010-01-01

Objetivos: identificar a quantidade de gorduras totais, saturadas e trans descritas nos rótulos de biscoitos recheados e verificar se existe associação entre o preço e a quantidade de gorduras trans Métodos: a amostra foi composta por 25 pacotes de biscoitos recheados de diferentes tipos e marcas, copiando-se de cada rótulo as informações necessárias. Para análise dos resultados foram efetuados cálculos de estatística descritiva, análise de variância e correlação de Spearmann Resultados...

Las Opiniones sacadas de los más auténticos y antigos philósofos que sobre la alma escrivieron i sus definiciones, de Daniel Arón Afia.

Directory of Open Access Journals (Sweden)

2008-06-01

Full Text Available Included in a volume published in 1568 in Venice alongside the first Spanish translation of Leon Hebreo’s Diálogos de amor, the Opiniones sacadas de los más auténticos y antigos philósofos que sobre la alma escrivieron y sus difiniciones, were written by Aron Daniel Afia, an important Latin and Philosophy scholar in the Salonika of the second half of the 16th c. Descendant of a Converso family returned to Judaism after settlement in Ottoman lands, his short twelve folio work is a compendium of definitions of the soul proposed by thinkers from Antiquity to Renaissance, being a precious example of the intellectual activity (in Latin, Spanish and Hebrew of the Conversos who chose exile in the Levant. The volume, dedicated to Philip II, shows the attachment of former Conversos to Spanish culture.Las Opiniones sacadas de los más auténticos y antigos philósofos que sobre la alma escrivieron y sus definiciones fueron publicadas en 1568 en Venecia, junto con la primera traducción española de los Diálogos de amor de León Hebreo. Escritas por Daniel Arón Afia, profesor de latín y filosofía establecido en la Salónica de la segunda mitad del siglo XVI, este autor de familia conversa vuelta al judaísmo tras su establecimiento en tierras otomanas. El opúsculo de apenas doce folios es un compendio de definiciones del alma propuestas por pensadores, desde la Antigüedad hasta el Renacimiento, muestra de la actividad intelectual desarrollada en hebreo, latín y castellano de los conversos que escogieron la vía del exilio en el Levante mediterráneo. El volumen fue dedicado a Felipe II y muestra el apego de su promotor a la cultura hispánica.

Polarization in high Psub(trans) and cumulative hadron production

International Nuclear Information System (INIS)

Efremov, A.V.

1978-01-01

The final hadron polarization in the high Psub(trans) processes is analyzed in the parton hard scattering picture. Scaling assumption allows a correct qualitative description to be given for the Psub(trans)-behaviour of polarization or escape angle behaviour in cumulative production. The energy scaling and weak dependence on the beam and target type is predicted. A method is proposed for measuring the polarization of hadron jets

HIV Prevalence, Sexual Partners, Sexual Behavior and HIV Acquisition Risk Among Trans Men, San Francisco, 2014.

Science.gov (United States)

McFarland, Willi; Wilson, Erin C; Raymond, Henry F

2017-12-01

We surveyed 122 trans men using a hybrid sampling method that included randomly selected physical and online venues and peer referral to measure HIV prevalence and risk behaviors. HIV prevalence was 0% (one-sided 97.5% confidence interval 0-3.3%). Of 366 partnerships described, 44.8% were with cisgender women, 23.8% with cisgender men, 20.8% with trans men, and 10.7% with trans women. Condomless receptive anal and front hole/vaginal sex averaged one to three episodes per six months. HIV prevalence in trans men is likely closer to heterosexual cisgender men and women in San Francisco than trans women or MSM. Prevention prioritizing trans women and MSM, coupled with individualized and relevant sexual health education for trans men with partners from these populations, may best address the HIV prevention needs of trans men. Systematic collection of transgender status in Census and health data is needed to understand other health disparities among trans men.

Patient radiation exposure in right versus left trans-radial approach for coronary procedures

Energy Technology Data Exchange (ETDEWEB)

Rigattieri, Stefano; Di Russo, Cristian; Cera, Maria; Fedele, Silvio; Sciahbasi, Alessandro [Interventional Cardiology Unit, Sandro Pertini Hospital, Rome (Italy); Pugliese, Francesco Rocco [Emergency Department Sandro Pertini Hospital, Rome (Italy)

2015-01-15

Objectives: The aim of this study was to compare radiation exposure, assessed by dose-area product (DAP), in right trans-radial approach (RR) versus left trans-radial approach (LR) for coronary procedures. Background: In LR the catheter course is more similar to trans-femoral approach, thus allowing an easier negotiation of coronary ostia which, in turn, might translate into reduced fluoroscopy time (FT) and radiation exposure as compared to RR. Methods: We retrospectively selected diagnostic and interventional procedures (PCI) performed by RR or LR at our center from May 2009 to May 2014. We only included in the analysis the procedures in which DAP values were available. Results: We analyzed 1464 procedures, 1175 of which performed by RR (80.3%) and 289 by LR (19.7%). Median DAP values were significantly higher in RR as compared to LR for diagnostic and interventional procedures (4482 vs. 3540 cGy.cm{sup 2} and 11523 vs. 10086 cGy.cm{sup 2}, respectively; p < 0.05). No significant differences were observed in FT and in contrast volume (CV). In the propensity-matched cohort, consisting of 269 procedures for each group, no significant differences between LR and RR were observed in median DAP values for both diagnostic and interventional procedures (3990 vs. 3542 cGy.cm{sup 2} and 9964 vs. 10216 cGy.cm{sup 2}, respectively; p = ns); FT and CV were also similar. At multiple linear regression analysis laterality of trans-radial approach was not associated with DAP. Conclusions: In an experienced trans-radial center LR is not associated with a reduction in radiation exposure, FT or CV as compared to RR. - Highlights: • Right trans-radial approach is by far more commonly used than left trans-radial approach. • Left trans-radial approach has the advantage of an easier catheter manipulation, more similar to trans-femoral approach. • This could reduce fluoroscopy time and radiation exposure. • We conducted a retrospective study to investigate patient radiation

TransCanada Corporation 2003 annual report

International Nuclear Information System (INIS)

2004-01-01

This annual report presents financial information from TransCanada Corp., along with a review of its operations throughout 2003 and a summary of the how the company performed in terms of providing natural gas transmission and power services in North America. In 2003, TransCanada increased earnings from continuing operations by 7 per cent. It maintained a strong cash flow and continued to strengthen its balance sheet. More than 1.2 billion was invested and dividends were increased by 7 per cent in January 2004, for a total return to shareholders of 27 per cent, including dividends. In 2003, TransCanada also increased its ownership interest in Foothills Pipe Lines Ltd. to 100 per cent from 50 per cent. It secured a position in the Mackenzie Gas Pipeline Project and progressed the development of multiple liquefied natural gas projects in the northeast United States and eastern Canada. The company acquired 31.6 per cent interest in Bruce Power, adding nearly 1,500 megawatts base load generation to its portfolio. Plans are underway for cogeneration plants in Quebec, New Brunswick and Alberta. This report summarized the company's energy resource activities and presented an operations review as well as consolidated financial statements and common share information. This included the utility's assets, liabilities, revenues, expenses and cash flows. Revenue and expenditure statements were summarized by source. tabs., figs

TransCanada Corporation 2004 annual report

International Nuclear Information System (INIS)

2005-01-01

TransCanada is a leading North American energy company dealing with natural gas transmission, power generation and marketing opportunities. Financial information from TransCanada was presented in this annual report along with a review of its operations in 2004 and a summary of how the company performed in terms of providing natural gas transmission and power services in North America. In 2004, TransCanada increased earnings from continuing operations and maintained a strong cash flow and continued to strengthen its balance sheet. Achievements in 2004 included the acquisition of the Gas Transmission Northwest Pipeline System and the North Baja Pipeline System; the purchase of hydroelectric generation assets in New England with a total generating capacity of more than 500 MW; and the completed construction of two new gas-fired cogeneration plants, the 165 MW MacKay River facility in Alberta and the 90 MW Grandview facility in New Brunswick. The challenges in 2004 included the performance of the company's existing asset-based businesses and the new initiatives to produce another year of solid operating and financial results. This report summarized the company's energy resource activities and presented an operations review as well as consolidated financial statements and common share information. This included the utility's assets, liabilities, revenues, expenses and cash flows. Revenue and expenditure statements were summarized by source. tabs., figs

75 FR 33799 - EasTrans, LLC; Notice of Baseline Filing

Science.gov (United States)

2010-06-15

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR10-30-000] EasTrans, LLC; Notice of Baseline Filing June 8, 2010. Take notice that on June 4, 2010, EasTrans, LLC submitted a baseline filing of its Statement of Operating Conditions for services provided under section 311 of the...

PREDIKSI PENGGUNA BUS TRANS SARBAGITA DENGAN METODE ADAPTIVE NEURO FUZZY INFERENCE SYSTEM

Directory of Open Access Journals (Sweden)

SLAMET SAMSUL HIDAYAT

2013-08-01

Full Text Available Trans Sarbagita is a public transportation services people at Denpasar, Badung, Gianyar and Tabanan. Trans Sarbagita is aimed to resolve a problems caused by accretion volume of vehicles in Bali. This study conducted to forecast the number of Trans Sarbagita passengers in 2013 using ANFIS. The ANFIS system composed by five layers where each layers has a different function and its divide in two phases, i.e. forward and backward phases. The ANFIS uses a hybrid learning algorithm which is a combination of Least Squares Estimator (LSE on forwards phases and Error Backpropagation (EBP on the backward phases. The results show, ANFIS with six inputs with M.F of  Pi  produces smallest error, compared to seven and eight input and M.F gauss and generalizedbell. Forecast of Trans Sarbagita passenger numbers in 2013 have to fluctuated every day and the average of passenger’s Trans Sarbagita for a day is 1627 passengers with MSE equal to 10210 and MAPE is 4.01%.

PREDIKSI PENGGUNA BUS TRANS SARBAGITA DENGAN METODE ADAPTIVE NEURO FUZZY INFERENCE SYSTEM

Directory of Open Access Journals (Sweden)

SLAMET SAMSUL HIDAYAT

2013-11-01

Full Text Available Trans Sarbagita is a public transportation services people at Denpasar, Badung, Gianyar and Tabanan. Trans Sarbagita is aimed to resolve a problems caused by accretion volume of vehicles in Bali. This study conducted to forecast the number of Trans Sarbagita passengers in 2013 using ANFIS. The ANFIS system composed by five layers where each layers has a different function and its divide in two phases, i.e. forward and backward phases. The ANFIS uses a hybrid learning algorithm which is a combination of Least Squares Estimator (LSE on forwards phases and Error Backpropagation (EBP on the backward phases. The results show, ANFIS with six inputs with M.F of  Pi  produces smallest error, compared to seven and eight input and M.F gauss and generalizedbell. Forecast of Trans Sarbagita passenger numbers in 2013 have to fluctuated every day and the average of passenger’s Trans Sarbagita for a day is 1627 passengers with MSE equal to 10210 and MAPE is 4.01%.

Trans-acting translational regulatory RNA binding proteins.

Science.gov (United States)

Harvey, Robert F; Smith, Tom S; Mulroney, Thomas; Queiroz, Rayner M L; Pizzinga, Mariavittoria; Dezi, Veronica; Villenueva, Eneko; Ramakrishna, Manasa; Lilley, Kathryn S; Willis, Anne E

2018-05-01

The canonical molecular machinery required for global mRNA translation and its control has been well defined, with distinct sets of proteins involved in the processes of translation initiation, elongation and termination. Additionally, noncanonical, trans-acting regulatory RNA-binding proteins (RBPs) are necessary to provide mRNA-specific translation, and these interact with 5' and 3' untranslated regions and coding regions of mRNA to regulate ribosome recruitment and transit. Recently it has also been demonstrated that trans-acting ribosomal proteins direct the translation of specific mRNAs. Importantly, it has been shown that subsets of RBPs often work in concert, forming distinct regulatory complexes upon different cellular perturbation, creating an RBP combinatorial code, which through the translation of specific subsets of mRNAs, dictate cell fate. With the development of new methodologies, a plethora of novel RNA binding proteins have recently been identified, although the function of many of these proteins within mRNA translation is unknown. In this review we will discuss these methodologies and their shortcomings when applied to the study of translation, which need to be addressed to enable a better understanding of trans-acting translational regulatory proteins. Moreover, we discuss the protein domains that are responsible for RNA binding as well as the RNA motifs to which they bind, and the role of trans-acting ribosomal proteins in directing the translation of specific mRNAs. This article is categorized under: RNA Interactions with Proteins and Other Molecules > RNA-Protein Complexes Translation > Translation Regulation Translation > Translation Mechanisms. © 2018 Medical Research Council and University of Cambridge. WIREs RNA published by Wiley Periodicals, Inc.

Le rôle de l’intertexte et du palimpseste dans la création d’une Écosse mythique dans Waverley et Rob Roy de Walter Scott

Directory of Open Access Journals (Sweden)

Céline SABIRON

2010-03-01

Full Text Available L’Écosse des Lumières, récemment rattachée à sa puissante voisine anglaise par l’Acte d’Union de 1707, connaît une crise identitaire qui l’amène à une redéfinition de son image. Sa représentation, tant tangible, physique que mentale, nationale, passe par une réécriture de son Histoire par le mythe, ce récit imaginaire populaire ou littéraire mettant en scène des êtres surhumains et des actions remarquables qui est, selon Roland Barthes, « un discours, un système de communication, un message » (Mythologies. Ce message d’une re-construction identitaire est transmis par Walter Scott dans ses romans écossais, en particulier Waverley et Rob Roy qui dépeignent l’Écosse et ses habitants à travers les yeux naïfs d’érudits anglais. Ce portrait textuel, loin d’être un tableau réaliste, est brossé à l’aide d’une superposition d’images mythiques et littéraires, notamment dans la description des paysages des Highlands. De plus, les personnages, tel le héros populaire historique et hors-la-loi écossais Rob Roy, sont transformés, romancés, mythifiés dans ces fictions qui retracent, sous forme d’épopée, les grandes révoltes jacobites de 1715 et 1745. Enfin, le langage pictural et imagé contribue à véhiculer une vision mythique de l’Écosse. Nous chercherons donc à comprendre et à expliquer les motivations et les répercussions de ce maillage d’images fictives connues, tirées de mythes ou d’ouvrages littéraires, et tissées au moyen d’images rhétoriques au texte scottien pour créer nouveau visage écossais.Recently united to its powerful English twin sister through the 1707 Union Act, Scotland experiences a major identity crisis in the Enlightenment. Politically, religiously, and socially divided, it is led to redefine its image by rewriting history through mythology. A myth is “a speech, a system of communication, a message”, Roland Barthes explains in Mythologies. This message

Trans-ligand-dependent arrangement (bent or linear) of Pt II-bound dialkylcyanamide ligands: Molecular structure of trans-dichloro(dimethylcyanamide)(dimethyl sulfoxide)platinum(II)

Science.gov (United States)

Anisimova, Tatyana B.; Bokach, Nadezhda A.; Fritsky, Igor O.; Haukka, Matti

2011-11-01

The title compound, trans-[PtCl 2(NCNMe 2)(Me 2SO)], is the first example of the structurally characterized Pt II species having the nitrile and the sulfoxide ligands in the trans-position to each other. The most significant feature of this structure is the non-linear arrangement of the Pt sbnd N1 sbnd C1 fragment providing the rare case of the bent form of the dialkylcyanamide ligand.

cis–trans Isomerization of silybins A and B

Directory of Open Access Journals (Sweden)

Michaela Novotná

2014-05-01

Full Text Available Methods were developed and optimized for the preparation of the 2,3-cis- and the 10,11-cis-isomers of silybin by the Lewis acid catalyzed (BF3∙OEt2 isomerization of silybins A (1a and B (1b (trans-isomers. The absolute configuration of all optically pure compounds was determined by using NMR and comparing their electronic circular dichroism data with model compounds of known absolute configurations. Mechanisms for cis–trans-isomerization of silybin are proposed and supported by quantum mechanical calculations.

Mandatory food labeling of trans fat acids: qualitative analysis of the public consultation

Directory of Open Access Journals (Sweden)

Vanessa Fernandes Davies

Full Text Available The objective of this paper is to identify the stakeholders and their contributions to the public consultation carried out with regard to the mandatory trans fat acids food labeling proposal in Brazil. Methodology thematic analysis of the documents. Results 25 stakeholders made suggestions regarding the proposed law, and the majority belonged to the food industry sector. The following issues were raised: lack of knowledge among the consumers about trans fat acids; lack of information about trans fat acids in food composition tables and infrastructure to analyse the trans fat content of foods; voluntary trans fat labelling. Conclusions The stakeholders addressed important issues, such as improving nutritional knowledge among the population. However, few stakeholders linked to consumers took part in the public consultation, which might lead to disproportionate influence of the food industry on the development of future food policies.

A trans European Union difference in the decline in trans fatty acids in popular foods

DEFF Research Database (Denmark)

Stender, Steen; Astrup, Arne; Dyerberg, Jørn

2012-01-01

To minimise the intake of industrial trans fatty acids (I-TFA) some countries have introduced labelling, while others have introduced legislative limits on the content of I-TFA in food. However, most countries still rely on food producers to voluntarily reduce the I-TFA content in food. The objec...

Use of Trans Fat Information on Food Labels and Its Determinants in a Multiethnic College Student Population

Science.gov (United States)

Jasti, Sunitha; Kovacs, Szilvia

2010-01-01

Objectives: To examine the correlates of trans fat knowledge and trans fat label use; to examine the influence of trans fat knowledge, trans fat label use, and dietary attitudes on intake of high trans fat food. Design: Cross-sectional survey. Setting: An urban commuter college. Subjects: Two hundred twenty-two college students. Variables…

Better faster cheaper: TransCanada PipeLines Ltd. 2000 annual report

International Nuclear Information System (INIS)

2000-01-01

Financial information from TransCanada was presented along with a review of their operations throughout 2000, including a summary of actions in the area of management, strategy, and policy. The company's efforts in 2000 were directed at restoring and strengthening their financial position by strengthening their balance sheet, restoring earnings, establishing a growth platform for future earnings and positioning the company with discretionary cash flow. In 2000, TransCanada substantially completed its divestiture program and sold assets for proceeds of nearly $3.4 billion. These proceeds have been used mainly to reduce debt and associated financial charges. TransCanada also made successful bids in Alberta's power auctions, increased ownership in Ocean State power and TransCanada Power, L.P. In addition, the company began development of two new power plants in Alberta. These initiatives are expected to contribute to an increase in earnings. tabs., figs

Few atom chemistry of the trans actinide element rutherfordium (Rf)

International Nuclear Information System (INIS)

Nagame, Y.

2002-01-01

Studies of chemical properties of the trans actinide elements - starting with element 104 (Rf) - offer the unique opportunity to obtain information about trends in the Periodic Table at the limits of nuclear stability and to assess the magnitude of the influence of relativistic effects on chemical properties. To explore experimentally the influence of relativistic effects of electron shell structure, we study the chemical properties of the trans actinide elements. So far, we have developed some experimental apparatuses for the study of chemical properties of the trans actinide elements: a beam-line safety system for the usage of the gas-jet coupled radioactive 248 Cm target chamber for the production of trans actinides, a rotating wheel catcher apparatus for the measurement of α particles and spontaneous fission decay of trans actinides and an automated rapid chemical separation apparatus based on high performance liquid chromatography. The trans actinide nuclide, the element 104, 261 Rf (t 1/2 = 78 s) has been successfully produced via the reactions of 248 Cm( 18 O,5n) at the JAERI (Japan Atomic Energy Research Institute) tandem accelerator. The evaluated production cross section was about 10 nb, indicating that the production rate was approximately 2 atoms per min. Because of the short half-life and the low production rate of Rf, each atom produced decays before a new atom is synthesized. It means that any chemistry to be performed must be done on an 'atom-at-a-time' basis. Therefore rapid, very efficient and selective chemical procedures are indispensable to isolate the desired trans actinide 261 Rf. To perform fast and repetitive ion-exchange separation of Rf, we have developed the apparatus AIDA (Automated Ion exchange separation system coupled with the Detection apparatus for Alpha spectroscopy). Recently, ion-exchange behavior of Rf in acidic solutions has been studied with AIDA, and the results indicate that anion-exchange behavior of Rf is quite similar

Acides gras polyinsaturés trans : aspects métaboliques

Directory of Open Access Journals (Sweden)

Sebedio Jean-Louis

2000-01-01

Full Text Available Les acides gras trans polyinsaturés sont formés à partir des acides gras indispensables (acides linoléique et a-linolénique au cours des traitements technologiques comme par exemple le raffinage des huiles ou la friture [1, 2]. L’acide linolénique est plus sensible à l’isomérisation que l’acide linoléique. En effet, comme l’a montré Wolff dans une revue récente [3], le degré d’isomérisation de l’acide linolénique peut atteindre 30 à 35 %. On retrouve également ces pourcentages dans les formules infantiles et le lait de femme [1]. Les principaux isomères formés sont les composés monotrans, à savoir les 18 :2-9trans,12cis, 18 :2-9cis,12trans, 18 :3-9trans,12cis,15cis, et le 18 :3-9cis,12cis,15-trans. Cependant, une température de désodorisation supérieure à 220 °C entraîne la formation d’isomères di-trans [4]. À titre d’exemple, nous avons représenté dans le tableau le contenu de quelques huiles végétales en isomères des acides linoléique et a-linolénique. Compte tenu de leur présence dans l’alimentation, on peut s’interroger sur les conséquences nutritionnelles et biochimiques de leur ingestion.

Uncovering the Boundary-spanning Role of Information Systems Research in Trans-Disciplinary Knowledge Advancement

DEFF Research Database (Denmark)

Liu, Fei; Lim, Eric T. K.; Tan, Chee-Wee

2017-01-01

Intrigued by the important yet underexplored inter-disciplinary impact of IS discipline, this study investigates the inter-disciplinary role played by IS discipline in trans-disciplinary knowledge advancement. To achieve this objective, this study firstly advanced a Model of Trans-Disciplinary Kn......Intrigued by the important yet underexplored inter-disciplinary impact of IS discipline, this study investigates the inter-disciplinary role played by IS discipline in trans-disciplinary knowledge advancement. To achieve this objective, this study firstly advanced a Model of Trans......-Disciplinary Knowledge Advancement that posits a process that consists of three stages of thesis, antithesis, and synthesis with two transitions, namely knowledge liquidization and crystallization, in two modes, namely boundary-reinforcing and boundary-spanning. In light of this model, this study conducted...... elicited. Results from an in-depth bibliographic analysis on these central articles shed light on four distinct trans-disciplinary roles (i.e., spanner, innovator, aggregator, and reinforcer) and trans-disciplinary characteristics of IS research....

Rancang Bangun Aplikasi Angkutan Trans Sarbagita Provinsi Bali Berbasis Perangkat Bergerak

Directory of Open Access Journals (Sweden)

I Made Aditya Pradnyadipa Mustika

2017-03-01

Full Text Available Trans Sarbagita merupakan salah satu upaya pemerintah Bali dalam menyediakan fasilitas angkutan umum untuk mengurangi kemacetan. Trans Sarbagita adalah sebuah fasilitas BRT (Bus Rapid Transit yang memiliki angkutan pengumpan tersendiri untuk mengangkut penumpang ke halte-halte bus terdekat. Trans Sarbagita sendiri sudah memiliki rencana rute untuk armada bus dan pengumpan mereka. Dari sebagian rute yang sudah beroperasi, informasi seputar rute, dan halte yang sudah beroperasi dirasa belum terpublikasi dengan baik sehingga dapat menjadi masalah bukan hanya untuk masyarakat Bali, tapi juga untuk para wisatawan yang ingin menggunakan fasilitas tersebut. Salah satu cara mengatasi permasalahan tersebut adalah dengan membangun sebuah aplikasi yang berisikan informasi mengenai halte dan rute-rute yang dapat ditempuh untuk mencapai tujuan yang dapat diakses melalui perangkat bergerak. Aplikasi Trans Sarbagita dapat memberikan rute terpendek yang dapat dilalui trayek pengumpan berdasarkan lokasi awal dan tujuan pengguna yang dikalkulasikan dengan algoritma Dijkstra. Selain menampilkan rute terpendek, aplikasi ini juga dapat menampilkan rute trayek serta lokasi halte Trans Sarbagita yang sudah beroperasi. Hasil uji coba sistem sudah menunjukkan berjalannya sistem dengan baik sesuai dengan perancangan awal. Meskipun demikian pengembangan lebih lanjut masih dibutuhkan untuk mengimbangi berkembangnya teknologi, serta berubahnya kebutuhan pengguna yang dapat diaplikasikan pada aplikasi ini.

News media coverage of trans fat: health risks and policy responses.

Science.gov (United States)

Jarlenski, Marian; Barry, Colleen L

2013-01-01

Prior research indicates that the news media play a critical role in transmitting information to the public about the most pressing public health problems, and framing attributions about who in society is responsible for solving these problems. In this article, we use content analysis methods to study the agenda-setting and framing functions of the news media in shaping perceptions about the health risks posed by trans fat in the U.S. diet. A census of news stories focusing on trans fat was collected from the two largest circulation U.S. newspapers and three major television networks from 1998 to 2008 (N = 156). The content of news coverage was analyzed using a 23-item instrument. Findings indicated that the news media served an important agenda-setting role in educating the public about the presence of trans fat in the U.S. diet and describing the health risks these foods pose. In addition, results indicate that news media coverage framed attributions of responsibility for solving the problem of trans fat in the food supply. News stories noting the heart disease risks of trans fat were significantly more likely to mention governmental responses aimed at curbing consumption than news coverage that did not note these health risks.

Conjugated linoleic acid (CLA. Cis 9, trans 11 and trans 10, cis 12 isomer detection in crude and refined corn oils by capillary GC

Directory of Open Access Journals (Sweden)

Özlem Tokuşoğlu

2008-06-01

Full Text Available Conjugated linoleic acids (CLAs exhibit protective effects against various types of cancer and heart diseases. With the newly developed capillary gas chromatographic method (GC, cis9, trans11 and trans10, cis12 octadecadienoic acid isomers of CLA (C18:2 were determined in crude and refined corn oils as qualitative and quantitative measurements. Cis 9, trans11 C18:2 (c9, t11 CLA was the major CLA isomer in both oils. It was found that c9, t11 CLA was 0.62% of the total lipid in crude oil and 1.24% of the total lipid in refined oil. Using the refining process, the total CLA was 1.38% whereas that of crude corn oil was 0.62%. An approximate 2.2 fold increase in the total CLA was found in refined oil (n = 9 (p y = 2.782x + 0.046 (R2 = 0.9999] were performed (p El ácido linoleico conjugado (CLA parece exhibir efecto protector frente a enfermedades cardiovasculares y varios tipos de cáncer. En este trabajo, se establece un mátodo analítico mediante cromatografía de gases con columna capilar para la determinación cualitativa y cuantitativa de los isómeros cis 9,trans 11 y trans 10, cis 12 en aceites de maiz crudo y refinado. El isómero cis 9, trans11 C18:2 fue el mayoritario encontrándose en concentraciones de 0.62% en el aceite cru,do y de 1.24 % en el aceite refinado. La cantidad total de CLA encontrada en el aceite refinado (n = 9 (p 2 = 0.9999 y de recuperación [y = 2.782x+0.046 (R2 = 0.9999]. El método cromatográfico propuesto podría ser usado para el control de calidad de los aceites vegetales.

A prospective study of trans fat intake and risk of preeclampsia in Denmark

DEFF Research Database (Denmark)

Chavarro, J. E.; Halldorsson, T. I.; Leth, Torben

2011-01-01

Association of intake of trans fatty acids in the 2nd trimester of pregnancy with risk of preeclampsia was studied by following 67 186 pregnancies of women participating in the Danish National Birth Cohort between 1998 and 2003. Diet was assessed with a food frequency questionnaire at gestation wk...... 25; preeclampsia diagnosis was obtained by linkage with the Danish National Patient Registry. 1804 cases of preeclampsia and 402 cases of severe preeclampsia were identified in the cohort. Intake of trans fats decreased during the study period as a consequence of reduction in industrial trans fat...... intake. Intake of trans fats in the 2nd trimester was unrelated to risk of preeclampsia or severe preeclampsia. Relative risk (95% confidence interval; P, trend) of preeclampsia and severe preeclampsia comparing top to bottom quintiles of trans fat intake were 0.95 (0.81; 1.11, 0.33) and 1.07 (0.78; 1...

Effects of diabetic peripheral neuropathy on gait in vascular trans-tibial amputees.

Science.gov (United States)

Nakajima, Hiroshi; Yamamoto, Sumiko; Katsuhira, Junji

2018-07-01

Patients with diabetes often develop diabetic peripheral neuropathy, which is a distal symmetric polyneuropathy, so foot function on the non-amputated side is expected to affect gait in vascular trans-tibial amputees. However, there is little information on the kinematics and kinetics of gait or the effects of diabetic peripheral neuropathy in vascular trans-tibial amputees. This study aimed to clarify these effects, including the biomechanics of the ankle on the non-amputated side. Participants were 10 vascular trans-tibial amputees with diabetic peripheral neuropathy (group V) and 8 traumatic trans-tibial amputees (group T). Each subject's gait was analyzed at a self-selected speed using a three-dimensional motion analyzer and force plates. Ankle plantarflexion angle, heel elevation angle, and peak and impulse of anterior ground reaction force were smaller on the non-amputated side during pre-swing in group V than in group T. Center of gravity during pre-swing on the non-amputated side was lower in group V than in group T. Hip extension torque during loading response on the prosthetic side was greater in group V than in group T. These findings suggest that the biomechanical function of the ankle on the non-amputated side during pre-swing is poorer in vascular trans-tibial amputees with DPN than in traumatic trans-tibial amputees; the height of the center of gravity could not be maintained during this phase in vascular trans-tibial amputees with diabetic peripheral neuropathy. The hip joint on the prosthetic side compensated for this diminished function at the ankle during loading response. Copyright © 2018 Elsevier Ltd. All rights reserved.

Hybrid e-learning tool TransLearning

NARCIS (Netherlands)

Meij, van der Marjoleine G.; Kupper, Frank; Beers, P.J.; Broerse, Jacqueline E.W.

2016-01-01

E-learning and storytelling approaches can support informal vicarious learning within geographically widely distributed multi-stakeholder collaboration networks. This case study evaluates hybrid e-learning and video-storytelling approach ‘TransLearning’ by investigation into how its storytelling

Solvent-dependent regioselective oxidation of trans-chalcones using aqueous hydrogen peroxide

Energy Technology Data Exchange (ETDEWEB)

Peng, Wang; Jiabin, Yang; Lushen, Li, E-mail: jimin@seu.edu.cn [Southeast University, Nanjing (China). School of Biological Science and Medical Engineering; Jin, Cai; Chunlong, Sun; Min, Ji [Southeast University, Nanjing (China). School of Chemistry and Chemical Engineering

2013-03-15

A novel method for regioselective oxidation of trans-chalcones with hydrogen peroxide in acetonitrile to afford cinnamic acids is reported. Only trans-b-arylacrylic acids were observed. A wide range of functionalized products can be effectively produced from various chalcones in good to excellent yields. (author)

Letter to the editor: healthy alternatives to trans fats

Directory of Open Access Journals (Sweden)

Moulin Julie

2007-04-01

Full Text Available Abstract Consumption of trans fats is associated with an increase of cardiovascular disease (CVD risk. To comply with regulatory policies and public health authorities recommendations, trans fats should be replaced in food products. The study by Sundram et al. (Nutrition & Metabolism 2007, 4:3 reporting the effect on CVD risk factors of interesterified fat (IE and partially hydrogenated soybean oil (PHSO compared to palm olein (POL has been critically analyzed. The study design and in particular the composition of the tested fats was not suitable to properly answer the question raised regarding the effect of alternative ingredients to trans fats on plasma lipids. The observed effects are divergent with predicted data derived from the literature model consolidated using the individual results of 60 randomized clinical trials. The results of the study published by Sundram and co-workers have to be considered with awareness.

Structural modification of trans-cinnamic acid using Colletotrichum acutatum

Directory of Open Access Journals (Sweden)

Rodrigo Velasco B.

2012-01-01

Full Text Available Se estudió la biotransformación de ácido trans-cinámico mediante células completas del hongo fitopatógeno nativo colombiano Colletotrichum acutatum. Inicialmente, se evaluó la fungitoxicidad de este compuesto contraC. acutatum; el ácido trans-cinámico exhibió una toxicidad moderada a débil contra el microorganismo y aparentemente se presentó un mecanismo de detoxificación. Luego, para estudiar tal mecanismo y explorar la capacidad de este hongo para biotransformar el ácido trans-cinámico en productos con valor agregado, el microorganismo se incubó con el sustrato usando tres medios de cultivo diferentes (Czapeck-Dox, Sabouraud y PDB a condiciones ambientales. Usando el medio Czapeck-Dox, los cultivos completos de C.acutatum redujeron el ácido trans-cinámico, primero a aldehídos (transcinamaldehido y 3-fenilpropanal, luego a alcoholes (alcohol cinamílico y 3-fenil-1-propanol. Posteriormente, estos alcoholes fueron transformados a los correspondientes ésteres de acetilo. Sin embargo, algunos de estos productos estuvieron ausentes o presentes a una concentración diferente cuando se cambió el medio de cultivo. Los resultados sugieren un mecanismo de detoxificación en el cual el sistema carbonílico α,β-insaturado es afectado.Por otra parte, los productos metabólicos formados son compuestos útiles usados como fragancias y sabores. Por consiguiente, el metabolismo del ácido trans-cinámico usando C. acutatum puede proporcionar nuevos blancos metabólicos para controlar C. acutatum así como también una forma simple y eficiente para obtener sabores y perfumes, tales como el alcohol cinamílico y el 3-fenil-1-propanol, y sus ésteres de acetilo.

Relic dark energy from the trans-Planckian regime

International Nuclear Information System (INIS)

Mersini, Laura; Bastero-Gil, Mar; Kanti, Panagiota

2001-01-01

As yet, there is no underlying fundamental theory for the trans-Planckian regime. There is a need to address the issue of how the observables in our present Universe are affected by processes that may have occurred at super-Planckian energies (referred to as the trans-Planckian regime). Specifically, we focus on the impact the trans-Planckian regime has on two observables: namely, dark energy and the cosmic microwave background radiation (CMBR) spectrum. We model the trans-Planckian regime by introducing a 1-parameter family of smooth non-linear dispersion relations which modify the frequencies at very short distances. A particular feature of the family of dispersion functions chosen is the production of ultralow frequencies at very high momenta k (for k>M P ). We name the range of the ultralow energy modes (of very short distances) that have frequencies equal to or less than the current Hubble rate H 0 as the tail modes. These modes are still frozen today due to the expansion of the Universe. We calculate their energy today and show that the tail provides a strong candidate for the dark energy of the Universe. During inflation, their energy is about 122 to 123 orders of magnitude smaller than the total energy, for any random value of the free parameter in the family of dispersion relations. For this family of dispersions, we present the exact solutions and show that the CMBR spectrum is that of a (nearly) blackbody, and that the adiabatic vacuum is the only choice for the initial conditions

Effect of phenolic extracts on trans fatty acid formation during frying

Directory of Open Access Journals (Sweden)

Gamel, TH

1999-12-01

Full Text Available Olive oil (blend of refined and virgin and sunflower oil containing added methanol phenolic extracts of dry rosemary and olive vegetable water or the synthetic antioxidant BHA in combination with the extracts, were used in a frying process. Eight frying operations were performed at 180 °C with 24 hr intervals between fryings. During the frying period the trans fatty acids (TFA by capillary column gas chromatography (CC-GC were determined. Trans fatty acids of oleic and linoleic were increased with frying time in both the control oil samples. The rosemary additives (extracts alone and in combination with BHA decreased the level of trans fatty acids (mainly elaidic acid, while the addition of olive vegetable water did not have any effect.

Aceite de oliva (mezcla de virgen y refinado y aceite de girasol con extractos fenólicos de romero seco y aguas de vegetación de aceituna, o con el antioxidante sintético BHA en combinación con los extractos, se usaron en proceso de fritura. Se realizaron 8 operaciones de fritura a 180°C con intervalos de 24 h. Se determinaron los ácidos grasos trans (TFA por cromatografía de gases en columna capilar (CC-GC. Los ácidos grasos trans de oleico y linoleico aumentaron con el tiempo de fritura en las muestras de aceite control. Los extractos de romero, solos y en combinación con BHA, disminuyeron los niveles de ácidos grasos trans (principalmente ácido elaídico mientras que la adicción de aguas de vegetación de aceituna no tuvo ningún efecto.

[Application of individually designed trans-fissure approach in brain surgery: analysis of 90 cases].

Science.gov (United States)

Zhao, Ji-Zong; Wang, Shuo; Zhang, Mao-Zhi; Wang, Lei; Wang, Rong; Tang, Ya-Juan

2009-01-06

To explore the feasibility and value of trans-fissure approaches in brain surgery through individually designed craniotomy. Ninety patients with intracranial space-occupying lesions, 47 males and 58 females, aged (43 +/- 14) (1 - 68), were treated by individualized trans-fissure approach surgeries. Linear scalp incision or "horseshoe shape" scalp incision were designed to perform the operation, with a bone flap 3 - 4 cm in diameter. The shortest approach to reach the lesion was decided under the guidance of neuro-navigation and real-time B-mode ultrasonography. Then the lesions were removed through natural cortical fissures. Another 79 patients with intracranial space-occupying lesions, 53 males and 51 females, aged (42 +/- 11) (15 -73), undergoing classical surgeries in the same period were used as control group. The average operation time, size of bone flap, amount of blood loss, hospitalization time, and hospitalization cost were compared between these 2 groups. The operation time of the individually designed trans-fissure approach group was (3.1 +/- 1.6) hours (1.33 - 10.83 hours), significantly shorter than that of the control group [(4.8 +/- 1.9) hrs, P trans-fissure approach group was (173 +/- 168) ml (20 m - 500 ml), significantly less than that of the control group [(410 +/- 61) ml, P trans-fissure approach group was (12 +/- 5) cm2 [(1 - 25) cm2], significantly smaller than that of the control group [(20. +/- 9) cm2, P trans-fissure approach group received retransfusion, compared to 15 in the control group, during operation. No infection or other significant complications occurred after operation in the individually designed trans-fissure approach group. The hospitalization time of the individually designed trans-fissure approach group was (20 +/- 6) days (9 - 39 days), significantly shorter than that of the control group [(24 +/- 7) days, P trans-fissure approach group was (23171 +/- 7280) yuan RMB; significantly lower than that of the control group

Consideraciones taxonómicas en especies de Senecio de Argentina Taxonomic considerations on Argentine species of Senecio

Directory of Open Access Journals (Sweden)

Roberto D. Tortosa

2010-12-01

Full Text Available Se incluyen algunas especies de Senecio de Argentina, reconocidas hasta el presente como especies válidas, en la sinonimia de otras: S. francisci Phil. en S. polygaloides Phil.; S. gymnocaulos Phil. en S. kingii Hook. f.; S. molinae Phil. en S. glaber Less.; S. mustersii Speg. y su var. dentatus Cabrera en S. subumbellatus Phil. Senecio microcephalus Phil. y su var. angustifolius Cabrera son consideradas una variedad de S. subumbellatus y S. schreiteri Cabrera una variedad de S. leucostachys Baker. No se acepta la validez de las variedades Senecio gilliesii Hook. et Arn. var. dasycarpus Cabrera, S. glaber Less. var. pratensis (Phil. Cabrera, S. gnidioides Phil. var. gilvus (Phil. Cabrera, S. kingii Hook. f. var. paradoxus (Albov ex Kurtz Cabrera, S. leucomallus A. Gray var. incisus A. Gray, S. linariifolius Poepp. ex DC. var. heliophytoides (Phil. Reiche y var. subtomentosus Cabrera y de la forma S. perezii Cabrera fo. integerrimus Cabrera.

TRANS-NEPTUNIAN OBJECT LIGHTCURVES V1.1

Data.gov (United States)

National Aeronautics and Space Administration — This data set includes a collection of published lightcurves of trans-Neptunian objects published through December 2002. The collection includes lightcurves of 18...

The need for multisectoral food chain approaches to reduce trans fat consumption in India.

Science.gov (United States)

Downs, Shauna M; Singh, Archna; Gupta, Vidhu; Lock, Karen; Ghosh-Jerath, Suparna

2015-07-22

The World Health Organization (WHO) recommends virtually eliminating trans fat from the global food supply. Although several high-income countries have successfully reduced trans fat levels in foods, low- and middle-income countries such as India face additional challenges to its removal from the food supply. This study provides a systems analysis of the Indian food chain to assess intervention options for reducing trans fat intake in low-income consumers. Data were collected at the manufacturer, retailer and consumer levels. Qualitative interviews were conducted with vanaspati manufacturers (n = 13) and local food vendors (n = 44). Laboratory analyses (n = 39) of street foods/snacks sold by the vendors were also conducted. Trans fat and snack intakes were also examined in low-income consumers in two rural villages (n = 260) and an urban slum (n = 261). Manufacturers of vanaspati described reducing trans fat levels as feasible but identified challenges in using healthier oils. The fat content of sampled oils from street vendors contained high levels of saturated fat (24.7-69.3 % of total fat) and trans fat (0.1-29.9 % of total fat). Households were consuming snacks high in trans fat as part of daily diets (31 % village and 84.3 % of slum households) and 4 % of rural and 13 % of urban households exceeded WHO recommendations for trans fat intakes. A multisectoral food chain approach to reducing trans fat is needed in India and likely in other low- and middle-income countries worldwide. This will require investment in development of competitively priced bakery shortenings and economic incentives for manufacturing foods using healthier oils. Increased production of healthier oils will also be required alongside these investments, which will become increasingly important as more and more countries begin investing in palm oil production.

A first-in-man phase 1 trial for long-acting TransCon Growth Hormone.

Science.gov (United States)

Gilfoyle, David; Mortensen, Eva; Christoffersen, Eva Dam; Leff, Jonathan A; Beckert, Michael

2018-04-01

TransCon growth hormone (GH) is a sustained-release inactive prodrug consisting of unmodified GH transiently bound to an inert carrier molecule designed to release fully active GH over a one-week period. This was a first-in-man phase 1 randomized trial was to evaluate the safety, tolerability, immunogenicity, pharmacokinetics (PK), and pharmacodynamics (PD) of a single dose of TransCon GH as compared to equivalent doses of daily GH (Omnitrope) or placebo in healthy adults. Forty-four healthy male adults were randomized to 4 cohorts of 11 subjects, distributed in a 7:2:2 ratio (TransCon GH: Omnitrope: placebo). A single injection of 4 possible TransCon GH doses (i.e., 0.04, 0.08, 0.16, or 0.24mg GH/kg/wk) or two different Omnitrope doses (i.e., 0.08 or 0.16mg GH/kg/wk divided into 7 equal daily doses) were administered with subjects evaluated for adverse events, immunogenicity, and GH and insulin-like growth factor-1 (IGF-1) levels. TransCon GH was well tolerated; no serious adverse events occurred, no injection site reaction differences between TransCon GH, Omnitrope, or placebo were identified, no nodules or lipoatrophy were reported, and no anti-GH binding antibodies or ECG changes were detected. Overall, the exposure of GH (C max ) and IGF-1 (AUC 0-168h ) following administration of equivalent doses of TransCon GH and Omnitrope were similar. GH and IGF-1 kinetics showed a dose-proportional increase following a single SC administration of TransCon GH and indicated that the prodrug is suitable for weekly administration. These results support advancement of TransCon GH to pediatric and adult GHD trials. Clinical trial registration numbers: NCT01010425 (clinicaltrials.gov). Copyright © 2017 Elsevier Ltd. All rights reserved.

Comparing Trans-Spectrum and Same-Sex-Attracted Youth in Australia: Increased Risks, Increased Activisms

Science.gov (United States)

Jones, Tiffany; Hillier, Lynne

2013-01-01

Tran-spectrum youth include those who are gender questioning, transgender, intersex, genderqueer, and androgynous. Drawing on data from an Australian study of more than 3,000 same-sex-attracted and trans-spectrum youth aged 14 to 21, this article compares a group of 91 trans-spectrum youth from the study to "cisgender" same-sex-attracted…

Does your organization use gender inclusive forms? Nurses' confusion about trans* terminology.

Science.gov (United States)

Carabez, Rebecca; Pellegrini, Marion; Mankovitz, Andrea; Eliason, Mickey; Scott, Megan

2015-11-01

To describe nurses confusion around trans* terminology and to provide a lesson in Trans* 101 for readers. Of the estimated 9 million persons in the United States of America who are identified as lesbian, gay, bisexual and transgender, about 950,000 (0.2-0.5% of adult population) are identified as trans* (a term that encompasses the spectrum, including transgender, transsexual, trans man, trans woman and other terms). The Institute of Medicine (2011, The health of lesbian, gay, bisexual and transgender people: Building a foundation for better understanding. The National Academies Press, Washington, DC) identified transgender persons as an understudied population with significant need for health research, yet the nursing literature contains little guidance for educating nurses on trans* issues. This is a mixed methods structured interview design with nurse key informants. The scripted interview was based on the Health Care Equality Index, which evaluates patient-centred care to lesbian, gay, bisexual and transgender patients and families. These data were part of a larger research study that explored the current state of lesbian, gay, bisexual and transgender-sensitive nursing practice. Undergraduate nursing students recruited and interviewed 268 nurse key informants about gender inclusive forms (capable of identifying trans* patients) at their agencies. Only 5% reported use of gender inclusive forms, 44% did not know about inclusive forms, 37% did not understand what a gender inclusive form was and 14% confused gender with sexual orientation. The study demonstrated a critical need for education in gender identity and sexual orientation terminology. The lack of understanding of concepts and terminology may affect basic care of lesbian, gay, bisexual and transgender patients especially those who identify as transgender. © 2015 John Wiley & Sons Ltd.

Biscoito integral: fonte de fibra, isento de lactose e gordura trans. = Integral cookie: fiber source, free of lactose and trans fats.

Directory of Open Access Journals (Sweden)

Meire Ferrari de Castro

2008-12-01

Full Text Available A demanda por produtos isentos de lactose, gordura trans e rico em fi bra é crescente no mercado alimentício. O presente estudo de natureza transversal, com coleta de dados primários, teve como objetivo desenvolver um tipo de biscoito rico em fibras, isento de lactose e livre de gorduras trans. Os biscoitos foram submetidos à avaliação sensorial com 144 consumidores, freqüentadores de uma panifi cadora de Maringá, Paraná, sendo 61% (n = 88 sexo femininoe 39% (n = 56 do sexo masculino, na faixa etária de 15 a 80 anos de idades. Para o teste de aceitação do produto, utilizou-se a escala hedônica de nove pontos (1 a 9 e a intenção de compra do produto com uma escala de cinco pontos. Participaram da pesquisa 144 pessoas que relataram 59% de aceitação de 8 a 9 pontos na escala hedônica. Somente 1% desgostaram, em diferentes níveis, dos biscoitos produzidos. Para a intenção de compra, 79% dos julgadores apresentaram-se propensos a compra do produto. Em 21% dos casos, os julgadores ou estariam em dúvida (15% ou defi nitivamente não comprariam o produto (6%. O produto final apresentou quantidades satisfatórias de fibras, ficando insento de lactose e gordura trans. = The demand for products free of lactose, trans fats and high in fiber is increasing in the food market. The present study of transverse nature, with primary data collect, aimed to develop a type of cookie rich in fibers, exempt of lactos, free from trans fats. The cookies were submitted to sensory evaluation with 144 consumers, who attend a bakery in Maringá of Paraná State - Brazil, 61% (n = 88 female and 39% (n = 56 male, aged 15-80 years ages. For the test of acceptance of the product, been used the hedonic scale of nine points (1 to 9, and the intention of purchase of the product with a scale of fivepoints. Hundred and forty four people have participated in the research that told as acceptance from 8 to 9 points in the scale of 59%. Only 1% disgusted et

77 FR 22576 - Possible Revocation of Ocean Transportation Intermediary License No. 021899-Trans World Logistics...

Science.gov (United States)

2012-04-16

... Intermediary License No. 021899--Trans World Logistics Corporation; Order To Show Cause Trans World Logistics Corporation (Trans World Logistics) is an Indiana corporation, incorporated in October 2006. Records... Logistics maintains its principal offices at 702 Penny Lane, Plainfield, Indiana. BCL records identify the...

Standing balance in people with trans-tibial amputation due to vascular causes: A literature review.

Science.gov (United States)

Seth, Mayank; Lamberg, Eric

2017-08-01

Balance is an important variable to consider during the rehabilitation process of individuals with trans-tibial amputation. Limited evidence exists on the balance abilities of people with trans-tibial amputation due to vascular causes. The purpose of this article is to review literature and determine if standing balance is diminished in people with trans-tibial amputation due to vascular causes. Literature review. Data were obtained from PubMed, Google Scholar, OandP.org , CINHAL, and Science Direct. Studies were selected only if they included standing balance assessment of people with unilateral trans-tibial amputation due to vascular causes. The review yielded seven articles that met the inclusion criteria. The general test methodology required participants to stand still on force platforms, with feet together, while center of pressure or postural sway was recorded. According to the findings of this review, individuals with trans-tibial amputees due to vascular causes have diminished balance abilities. Limited evidence suggests their balance might be further diminished as compared to individuals with trans-tibial amputation due to trauma. Although the evidence is limited, because of the underlying pathology and presence of comorbidities in individuals with trans-tibial amputation due to vascular causes, one cannot ignore these findings, as even a minor injury from a fall may develop into a non-healing ulcer and affect their health and well-being more severely than individuals with trans-tibial amputation due to trauma. Clinical relevance Individuals with trans-tibial amputation due to vascular causes have diminished balance abilities compared to healthy individuals and individuals with trans-tibial amputation due to trauma. This difference should be considered when designing and fabricating prostheses. Prosthetists and rehabilitation clinicians should consider designing amputation cause-specific rehabilitation interventions, focussing on balance and other

Trans-abdominal ultrasound evaluation of high-intensity focused ultrasound treatment of uterine leiomyoma

International Nuclear Information System (INIS)

Miao Wei; Huang Jin; Wang Junhua; Wang Yuling

2010-01-01

Objective: To determine the value of dynamic trans-abdominal ultrasound after high-intensity focused ultrasound (HIFU) treatment of uterine leiomyomas. Methods: The trans-abdominal ultrasound images of 63 patients before and after HIFU treatment of uterine leiomyomas were compared. Results: The volume and blood flow of leiomyomas were reduced after the HIFU treatment. Conclusion: Trans-abdominal ultrasound is a valuable method for evaluating the results of HIFU treatment of uterine leiomyomas. (authors)

Componentes do modelo teórico de Roy em pacientes submetidos à hemodiálise

Directory of Open Access Journals (Sweden)

Cecília Maria Farias de Queiroz Frazão

Full Text Available Estudo transversal, objetivando identificar os componentes do modelo teórico de Roy em pacientes submetidos à hemodiálise em um centro de diálise. Participaram 178 pacientes de um centro dialítico no Nordeste do Brasil. A coleta de dados ocorreu de outubro/2011 a fevereiro/2012, por entrevista e exame físico. Os componentes identificados foram: problemas adaptativos, comportamentos e estímulos. Os principais problemas adaptativos foram: retenção de líquido intracelular, hipercalemia, hipotermia, edema, intolerância à atividade. Os comportamentos foram: anúria, desequilíbrio hidroeletrolítico, aumento de peso em curto período, aumento do potássio sérico, temperatura corporal abaixo de 36°C, retenção de líquidos, fadiga, dificuldade em realizar atividades de vida diária. Os estímulos foram: lesão renal, circulação extracorpórea, hemodiálise, não seguimento da restrição hídrica, distúrbio eletrolítico, ambiente frio, efeitos adversos relacionados ao tratamento. Conclui-se que a identificação desses componentes, enquadrados no modo fisiológico, contribui para o planejamento de intervenções de enfermagem específicas e voltadas para a adaptação da clientela.

Adaptación en pacientes con diabetes Mellitus Tipo 2, según Modelo de Roy

Directory of Open Access Journals (Sweden)

Margarita Lazcano-Ortiz

2009-01-01

Full Text Available Objetivo. Determinar la influencia entre estímulos focales y contextuales, y la adaptación fisiológica y psicosocial en personas con diabetes Mellitus Tipo 2 (DMT2. Material y método. El diseño fue descriptivo, transversal, predictivo. El muestreo fue probabilístico, sistemático. La muestra con 200 participantes de ambos géneros de 30 a 65 años, se determinó para un 95% de confianza, con una potencia de prueba de 90%. Resultados. Los resultados mostraron que el tiempo desde diagnóstico explicó la adaptación fisiológica F (1,198 = 9,18, p = ,003. Se observó efecto entre complicaciones y adaptación psicosocial F (4,195 = 4,97, p = ,001, con un coeficiente de determinación del 74%. Los estímulos contextuales influyeron en la adaptación fisiológica y psicosocial, F (6,193 = 2,89, p = ,010, y F (6, 193 = 2,41, p = ,029. Conclusiones. Los resultados de este estudio permiten sugerir relaciones entre las proposiciones teóricas propuestas y derivadas del Modelo de Adaptación de Roy, particularmente entre los estímulos y la adaptación fisiológica y psicosocial en pacientes con diabetes Mellitus Tipo 2.

Non-suicidal self-injury in trans people: associations with psychological symptoms, victimization, interpersonal functioning, and perceived social support.

Science.gov (United States)

Claes, Laurence; Bouman, Walter Pierre; Witcomb, Gemma; Thurston, Megan; Fernandez-Aranda, Fernando; Arcelus, Jon

2015-01-01

There is a paucity of systematic research in the area of non-suicidal self-injury (NSSI) in trans people. The aim of this study was to investigate the prevalence of NSSI in trans people and the associations with intra- and interpersonal problems. Participants were 155 untreated individuals with a diagnosis of transsexualism (according to International Classification of Disease-10 criteria) attending a national gender identity clinic. All participants completed the Self-Injury Questionnaire, the Symptom Checklist-90-Revised, the Rosenberg Self-Esteem Scale, the Hamburg Body Drawing Scale, the Experiences of Transphobia Scale, the Inventory of Interpersonal Problems-32, and the Multidimensional Scale of Perceived Social Support. The sample consisted of 66.5% trans women and 33.5% trans men and 36.8% of them had a history of engaging in NSSI. The prevalence of NSSI was significantly higher in trans men (57.7%) compared with trans women (26.2%). Trans individuals with NSSI reported more psychological and interpersonal problems and perceived less social support compared with trans individuals without NSSI. Moreover, the probability of having experienced physical harassment related to being trans was highest in trans women with NSSI (compared with those without NSSI). The study found that with respect to psychological symptoms, trans women reported significantly more intrapersonal and interpersonal symptoms compared with trans men. Finally, the results of the regression analysis showed that the probability of engaging in NSSI by trans individuals was significantly positively related to a younger age, being trans male, and reporting more psychological symptoms. The high levels of NSSI behavior and its association with interpersonal and interpersonal difficulties and lack of social support need to be taken into consideration when assessing trans individuals. The effect of cross-sex hormones and sex reassignment surgery on psychological functioning, including NSSI behavior

FACTS ABOUT TRANS FATTY ACIDS

Directory of Open Access Journals (Sweden)

Sedighe Asgary

2010-12-01

Full Text Available Introduction Fatty acids constitute the main class of lipids in the human diet, being found in nature mainly as glycerol esters that originate triacylglycerols. In the vegetal and animal kingdoms, fatty acids generally have cis unsaturations. In this form, the hydrogens bound to the double bond carbons are on the same side. In another possible configuration, called trans, the hydrogens are bound to un saturations, carbons on opposing sides. Fatty acids with one or more un saturations in the trans configuration are called trans fatty acids (TFAs.1-4      There are two major sources of TFA, those that come from ruminant animals and those that are industrially produced.      The majority of TFAs are found in partially hydrogenated vegetable oils, which contain 10–40% as TFA.5 Hydrogenation is based on the reaction of unsaturated fatty acids of either vegetable or marine oil in the presence of a catalyst, in general nickel. The objective is to increase the oxidative stability of oils by reduction of the concentration of more unsaturated fatty acids and changing their physical properties, thus extending their application. Hydrogenation depends mainly on oil temperature, hydrogen pressure, stirring speed, reaction time, and the catalyst type and concentration. According to the process conditions, hydrogenation is classified as either partial or total and either selective or nonselective.6 It has been estimated that dietary TFAs from partially hydrogenated oils may be responsible for between 30,000 and 100,000 premature coronary deaths per year in the United States.7      The concentration of TFA in meat and milk from ruminants (i.e., cattle, sheep, goats, etc. contain 3 to 8% of total fat.5 It is hypothesized that ruminant TFAs, or certain TFA isomers from ruminant sources, may confer some health benefits; however, since TFA from animal sources accompany saturated fatty acids (SFA, an increase in a single ruminant TFA in the diet is not

Synthesis, spectroscopic and TD-DFT quantum mechanical study of azo-azomethine dyes. A laser induced trans-cis-trans photoisomerization cycle.

Science.gov (United States)

Georgiev, Anton; Kostadinov, Anton; Ivanov, Deyan; Dimov, Deyan; Stoyanov, Simeon; Nedelchev, Lian; Nazarova, Dimana; Yancheva, Denitsa

2018-03-05

This paper describes the synthesis, spectroscopic characterization and quantum mechanical calculations of three azo-azomethine dyes. The dyes were synthesized via condensation reaction between 4-(dimethylamino)benzaldehyde and three different 4-aminobenzene azo dyes. Quantum chemical calculations on the optimized molecular geometry and electron densities of the trans (E) and cis (Z) isomers and their vibrational frequencies have been computed by using DFT/B3LYP density-functional theory with 6-311++G(d,p) basis set in vacuo. The thermodynamic parameters such as total electronic energy E (RB3LYP), enthalpy H 298 (sum of electronic and thermal enthalpies), free Gibbs energy G 298 (sum of electronic and thermal free Gibbs energies) and dipole moment μ were computed for trans (E) and cis (Z) isomers in order to estimate the ΔE trans→cis , Δμ trans→cis, ΔH trans→cis , ΔG trans→cis and ΔS trans→cis values. After molecular geometry optimization the electronic spectra have been obtained by TD-DFT calculations at same basis set and correlated with the spectra of vapour deposited nanosized films of the dyes. The NBO analysis was performed in order to understand the intramolecular charge transfer and energy of resonance stabilization. Solvatochromism was investigated by UV-VIS spectroscopy in five different organic solvents with increasing polarity. The dynamic photoisomerization experiments have been performed in DMF by pump lasers λ=355nm (mostly E→Z) and λ=491nm (mostly Z→E) in spectral region 300nm - 800nm at equal concentrations and times of illumination in order to investigate the photodynamical trans-cis-trans properties of the CHN and NN chromophore groups of the dyes. Copyright © 2017 Elsevier B.V. All rights reserved.

Energetics and Kinetics of trans-SNARE Zippering

Science.gov (United States)

Rebane, Aleksander A.; Shu, Tong; Krishnakumar, Shyam; Rothman, James E.; Zhang, Yongli

Synaptic exocytosis relies on assembly of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins into a four-helix bundle to drive membrane fusion. Complementary SNAREs anchored to the synaptic vesicle (v-SNARE) and the plasma membrane (t-SNARE) associate from their N-termini, transiting a half-assembled intermediate (trans-SNARE), and ending at their C-termini with a rapid power stroke that leads to membrane fusion. Although cytosolic SNARE assembly has been characterized, it remains unknown how membranes modulate the energetics and kinetics of SNARE assembly. Here, we present optical tweezers measurements on folding of single membrane proteins in phospholipid bilayers. To our knowledge, this is the first such report. We measured the energetics, kinetics, and assembly intermediates of trans-SNAREs formed between a t-SNARE inserted into a bead-supported bilayer and a v-SNARE in a nanodisc. We found that the repulsive force of the apposed membranes increases the lifetime of the half-assembled intermediate. Our findings provide a single-molecule platform to study the regulation of trans-SNARE assembly by proteins that act on the half-assembled state, and thus reveal the mechanistic basis of the speed and high fidelity of synaptic transmission. This work was supported by US National Institutes of Health Grants F31 GM119312-01 (to A.A.R) and R01 GM093341 (to Y.Z.).

Trigemino-cardiac reflex: occurrence of asystole during trans-sphenoidal adenomectomy: a case report.

Science.gov (United States)

Jeon, Dae Geun; Kang, Bong Jin; Hur, Tae Won

2014-09-01

The trigemino-cardiac reflex has been reported to occur during various craniofacial surgeries or procedures including manipulation of the trigeminal ganglion, tumor resection in the cerebellopontine angle, various facial reconstructions and trans-sphenoidal adenomectomy. Regarding risk factors during trans-sphenoidal adenomectomy, invasiveness closely related to the size of tumor and the degree of manipulation of cavernous sinus wall have been reported. We report the case of a 40-year-old female patient who had a relatively small-sized (trans-sphenoidal operation of the wall of the cavernous sinus, which strongly suggests the importance of careful manipulation of the cavernous sinus wall. In addition to reporting this rare complication of trans-sphenoidal adenomectomy, we reviewed its clinical management by performing a literature search.

Chemometric analysis of mass spectra of cis and trans fatty acid picolinyl esters

DEFF Research Database (Denmark)

Leth, Torben

1997-01-01

and trans fatty acids of C16:1, C18:1,n-9, C18:1,n-12, C18:2 and C22:1 in two- and three-dimensional score plots. With Soft Independent Modelling of Class Analogy (SIMCA), it is possible to calculate models that can predict from the mass spectra of unknown fatty acids whether they are of the cis or trans...... configuration, which is demonstrated for C18:1 trans from hardened margarine and butter....

A "Trans-Dyadic" Perspective on the Goldwater Rule.

Science.gov (United States)

Plakun, Eric M

2017-11-01

The Goldwater Rule has been debated, redefined, and debated further since the election of Donald Trump as President of the United States. This column offers a perspective on the Goldwater Rule that moves beyond psychiatry's current preoccupation with precision DSM-5 diagnosis of individuals, which ethically requires consent or other legal authorization for release of diagnostic information to others, and into the realm of leadership as seen through the "trans-dyadic" lens of psychoanalytic understanding of large group processes on a societal level. Concepts from large group psychology are introduced to illustrate "trans-dyadic" perspectives on leadership that do not challenge the Goldwater Rule.

Synthesis of racemic [methyl-d3]-labeled cis- and trans-3'-hydroxycotinine

International Nuclear Information System (INIS)

Ravard, A.; Crooks, P.A.

1994-01-01

A method is described for the synthesis of the racemic [methyl-d 3 ] forms of the nicotine metabolites cis-3'-hydroxycotinine and trans-3'-hydroxycotinine. The key intermediate was [methyl-d 3 ]-N-methylhydroxylamine, obtained from a selective hydrogenation of d 3 -nitro-methane. This intermediate was converted to [methyl-d 3 ]-α-3-pyridyl-N-methylnitrone, which was condensed with methyl acrylate to give a mixture of isomeric isoxazolidines. The hydrogenolysis of this mixture afforded a 70:30 mixture of [methyl-d 3 ] cis- and trans-3'-hydroxycotinine, from which the pure cis-isomer could be isolated by recrystallization from acetone. [Methyl-d 3 ]-trans-3'-hydroxycotinine could be prepared in high yield from the cis-isomer via chiral inversion utilizing a Mitsunobu reaction, or by chromatographic separation from a mixture of the cis- and trans-3'-benzoyloxycotinine, followed by O-debenzoylation in methanolic NaOH. (author)

Efficient hierarchical trans-dimensional Bayesian inversion of magnetotelluric data

Science.gov (United States)

Xiang, Enming; Guo, Rongwen; Dosso, Stan E.; Liu, Jianxin; Dong, Hao; Ren, Zhengyong

2018-06-01

This paper develops an efficient hierarchical trans-dimensional (trans-D) Bayesian algorithm to invert magnetotelluric (MT) data for subsurface geoelectrical structure, with unknown geophysical model parameterization (the number of conductivity-layer interfaces) and data-error models parameterized by an auto-regressive (AR) process to account for potential error correlations. The reversible-jump Markov-chain Monte Carlo algorithm, which adds/removes interfaces and AR parameters in birth/death steps, is applied to sample the trans-D posterior probability density for model parameterization, model parameters, error variance and AR parameters, accounting for the uncertainties of model dimension and data-error statistics in the uncertainty estimates of the conductivity profile. To provide efficient sampling over the multiple subspaces of different dimensions, advanced proposal schemes are applied. Parameter perturbations are carried out in principal-component space, defined by eigen-decomposition of the unit-lag model covariance matrix, to minimize the effect of inter-parameter correlations and provide effective perturbation directions and length scales. Parameters of new layers in birth steps are proposed from the prior, instead of focused distributions centred at existing values, to improve birth acceptance rates. Parallel tempering, based on a series of parallel interacting Markov chains with successively relaxed likelihoods, is applied to improve chain mixing over model dimensions. The trans-D inversion is applied in a simulation study to examine the resolution of model structure according to the data information content. The inversion is also applied to a measured MT data set from south-central Australia.

The european Trans-Tools transport model

NARCIS (Netherlands)

Rooijen, T. van; Burgess, A.

2008-01-01

The paper presents the use of ArcGIS in the Transtools Transport Model, TRANS-TOOLS, created by an international consortium for the European Commission. The model describe passenger as well as freight transport in Europe with all medium and long distance modes (cars, vans, trucks, train, inland

Alterations in cholesterol metabolism restrict HIV-1 trans infection in nonprogressors.

Science.gov (United States)

Rappocciolo, Giovanna; Jais, Mariel; Piazza, Paolo; Reinhart, Todd A; Berendam, Stella J; Garcia-Exposito, Laura; Gupta, Phalguni; Rinaldo, Charles R

2014-04-29

ABSTRACT HIV-1-infected nonprogressors (NP) inhibit disease progression for years without antiretroviral therapy. Defining the mechanisms for this resistance to disease progression could be important in determining strategies for controlling HIV-1 infection. Here we show that two types of professional antigen-presenting cells (APC), i.e., dendritic cells (DC) and B lymphocytes, from NP lacked the ability to mediate HIV-1 trans infection of CD4(+) T cells. In contrast, APC from HIV-1-infected progressors (PR) and HIV-1-seronegative donors (SN) were highly effective in mediating HIV-1 trans infection. Direct cis infection of T cells with HIV-1 was comparably efficient among NP, PR, and SN. Lack of HIV-1 trans infection in NP was linked to lower cholesterol levels and an increase in the levels of the reverse cholesterol transporter ABCA1 (ATP-binding cassette transporter A1) in APC but not in T cells. Moreover, trans infection mediated by APC from NP could be restored by reconstitution of cholesterol and by inhibiting ABCA1 by mRNA interference. Importantly, this appears to be an inherited trait, as it was evident in APC obtained from NP prior to their primary HIV-1 infection. The present study demonstrates a new mechanism wherein enhanced lipid metabolism in APC results in remarkable control of HIV-1 trans infection that directly relates to lack of HIV-1 disease progression. IMPORTANCE HIV-1 can be captured by antigen-presenting cells (APC) such as dendritic cells and transferred to CD4 helper T cells, which results in greatly enhanced viral replication by a mechanism termed trans infection. A small percentage of HIV-1-infected persons are able to control disease progression for many years without antiretroviral therapy. In our study, we linked this lack of disease progression to a profound inability of APC from these individuals to trans infect T cells. This effect was due to altered lipid metabolism in their APC, which appears to be an inherited trait. These

Trans Fat Bans and Human Freedom

Science.gov (United States)

Resnik, David

2014-01-01

A growing body of evidence has linked consumption of trans fatty acids to cardiovascular disease. To promote public health, numerous state and local governments in the United States have banned the use of artificial trans fats in restaurant foods, and additional bans may follow. Although these policies may have a positive impact on human health, they open the door to excessive government control over food, which could restrict dietary choices, interfere with cultural, ethnic, and religious traditions, and exacerbate socioeconomic inequalities. These slippery slope concerns cannot be dismissed as far-fetched, because the social and political pressures are place to induce additional food regulations. To protect human freedom and other values, policies that significantly restrict food choices, such as bans on types of food, should be adopted only when they are supported by substantial scientific evidence, and when policies that impose fewer restrictions on freedom, such as educational campaigns and product labeling, are likely to be ineffective. PMID:20229412

Boycunts and bonus holes: trans men's bodies, neoliberalism, and the sexual productivity of genitals.

Science.gov (United States)

Edelman, Elijah Adiv; Zimman, Lal

2014-01-01

Recent theorizations of trans embodiment have brought attention to the ways neoliberalism limits the productivity of nonnormatively gendered bodies. This article deals with the discursive framing of embodiment and sexual desirability among trans men and other transmasculine persons negotiating Internet-mediated homoerotic spaces. Micro-level analysis of discourse structure and macro-level analysis of socio-political context together show how trans men navigate homonormative sexual economies by linguistically recuperating their bodies' sexually productivity. Instead of undermining claims of embodied masculinity and homoerotic value, potential sites of exclusion-i.e., trans genitals-become sites of flexible accumulation that enhance rather than detract from their bearers' desirability.

Selective amygdalohippocampectomy via trans-superior temporal gyrus keyhole approach.

Science.gov (United States)

Mathon, Bertrand; Clemenceau, Stéphane

2016-04-01

Hippocampal sclerosis is the most common cause of drug-resistant epilepsy amenable for surgical treatment and seizure control. The rationale of the selective amygdalohippocampectomy is to spare cerebral tissue not included in the seizure generator. Describe the selective amygdalohippocampectomy through the trans-superior temporal gyrus keyhole approach. Selective amygdalohippocampectomy for temporal lobe epilepsy is performed when the data (semiology, neuroimaging, electroencephalography) point to the mesial temporal structures. The trans-superior temporal gyrus keyhole approach is a minimally invasive and safe technique that allows disconnection of the temporal stem and resection of temporomesial structures.

Trans-European transport networks and urban systems in European Union

OpenAIRE

Maksin-Mićić Marija

2003-01-01

The trans-European transport network has different effects at interregional macro-regional and mezzo-regional level, and its effectiveness rises at the lower regional levels. Possible approaches to the trans-European transport network impact and effect survey and policy options have been pointed out. In that respect the brief review of survies, strategic framework and policies in European Union has been given. The importance of increased accessibility and mobility for regional expansion and f...

A Gene Gun-mediated Nonviral RNA trans-splicing Strategy for Col7a1 Repair

Directory of Open Access Journals (Sweden)

Patricia Peking

2016-01-01

Full Text Available RNA trans-splicing represents an auspicious option for the correction of genetic mutations at RNA level. Mutations within COL7A1 causing strong reduction or absence of type VII collagen are associated with the severe skin blistering disease dystrophic epidermolysis bullosa. The human COL7A1 mRNA constitutes a suitable target for this RNA therapy approach, as only a portion of the almost 9 kb transcript has to be delivered into the target cells. Here, we have proven the feasibility of 5′ trans-splicing into the Col7a1 mRNA in vitro and in vivo. We designed a 5′ RNA trans-splicing molecule, capable of replacing Col7a1 exons 1–15 and verified it in a fluorescence-based trans-splicing model system. Specific and efficient Col7a1 trans-splicing was confirmed in murine keratinocytes. To analyze trans-splicing in vivo, we used gene gun delivery of a minicircle expressing a FLAG-tagged 5′ RNA trans-splicing molecule into the skin of wild-type mice. Histological and immunofluorescence analysis of bombarded skin sections revealed vector delivery and expression within dermis and epidermis. Furthermore, we have detected trans-spliced type VII collagen protein using FLAG-tag antibodies. In conclusion, we describe a novel in vivo nonviral RNA therapy approach to restore type VII collagen expression for causative treatment of dystrophic epidermolysis bullosa.

El Acuerdo TransPacífico y su efecto en América Latina/ The TransPacific Partnership Agreement and its effects on Latin America

Directory of Open Access Journals (Sweden)

Sergio Caballero Santos

2013-12-01

Full Text Available Actualmente se están negociando un Acuerdo TransPacífico en comercio e inversión, que abarca a un gran número de países bañados por el océano del mismo nombre, al mismo tiempo que se avanza en un acuerdo trans-Atlántico entre Estados Unidos y la Unión Europea. En este trabajo se aborda este escenario de megabloques comerciales desde la óptica de los efectos que pueda acarrear para América Latina y se visibiliza cómo estas formas de inserción internacional también ponen de manifiesto las diferentes lógicas existentes en el contexto latinoamericano. A TransPacific Trade and Investment Partnership Agreement is currently being negotiated among a great amount of countries in both sides of the Pacific ocean, while developing a TransAtlantic Partnership between the US and the EU. In this work this commercial scenario, covering several continents, is presented from a Latin American perspective, emphasizing the effects that these agreements could produce on this region. And furthermore, the analysis of these ways of international insertion shows us the competing logics which coexist across the Latin American region.

Changes in Trans Fat and Fatty Acids in Fast Food Menu Items

Science.gov (United States)

Recent interest in trans fatty acid intake and subsequent recommendations included in the 2005 Dietary Guidelines for Americans to decrease intake has led to extensive product reformulations of widely consumed foods high in trans fat. As part of these efforts to provide current and accurate nutrien...

Can trans-generational experiments be used to enhance species resilience to ocean warming and acidification?

Science.gov (United States)

Chakravarti, Leela J; Jarrold, Michael D; Gibbin, Emma M; Christen, Felix; Massamba-N'Siala, Gloria; Blier, Pierre U; Calosi, Piero

2016-10-01

Human-assisted, trans-generational exposure to ocean warming and acidification has been proposed as a conservation and/or restoration tool to produce resilient offspring. To improve our understanding of the need for and the efficacy of this approach, we characterized life-history and physiological responses in offspring of the marine polychaete Ophryotrocha labronica exposed to predicted ocean warming (OW: + 3°C), ocean acidification (OA: pH -0.5) and their combination (OWA: + 3°C, pH -0.5), following the exposure of their parents to either control conditions ( within-generational exposure ) or the same conditions ( trans-generational exposure ). Trans-generational exposure to OW fully alleviated the negative effects of within-generational exposure to OW on fecundity and egg volume and was accompanied by increased metabolic activity. While within-generational exposure to OA reduced juvenile growth rates and egg volume, trans-generational exposure alleviated the former but could not restore the latter. Surprisingly, exposure to OWA had no negative impacts within- or trans-generationally. Our results highlight the potential for trans-generational laboratory experiments in producing offspring that are resilient to OW and OA. However, trans-generational exposure does not always appear to improve traits and therefore may not be a universally useful tool for all species in the face of global change.

Transsynaptic Mapping of Second-Order Taste Neurons in Flies by trans-Tango.

Science.gov (United States)

Talay, Mustafa; Richman, Ethan B; Snell, Nathaniel J; Hartmann, Griffin G; Fisher, John D; Sorkaç, Altar; Santoyo, Juan F; Chou-Freed, Cambria; Nair, Nived; Johnson, Mark; Szymanski, John R; Barnea, Gilad

2017-11-15

Mapping neural circuits across defined synapses is essential for understanding brain function. Here we describe trans-Tango, a technique for anterograde transsynaptic circuit tracing and manipulation. At the core of trans-Tango is a synthetic signaling pathway that is introduced into all neurons in the animal. This pathway converts receptor activation at the cell surface into reporter expression through site-specific proteolysis. Specific labeling is achieved by presenting a tethered ligand at the synapses of genetically defined neurons, thereby activating the pathway in their postsynaptic partners and providing genetic access to these neurons. We first validated trans-Tango in the Drosophila olfactory system and then implemented it in the gustatory system, where projections beyond the first-order receptor neurons are not fully characterized. We identified putative second-order neurons within the sweet circuit that include projection neurons targeting known neuromodulation centers in the brain. These experiments establish trans-Tango as a flexible platform for transsynaptic circuit analysis. Copyright © 2017 Elsevier Inc. All rights reserved.

Minimally invasive endoscope-assisted trans-oral excision of huge parapharyngeal space tumors.

Science.gov (United States)

Li, Shang-Yi; Hsu, Ching-Hui; Chen, Mu-Kuan

2015-04-01

Parapharyngeal space tumors are rare head and neck neoplasms, and most are benign lesions. Complete excision of these tumors is difficult because of the complexity of the surrounding anatomic structures. The algorithm for excision of these tumors is typically based on the tumor's characteristics; excision is performed via approaches such as the trans-oral route, the trans-cervical route, and even a combination of the trans-parotid route and mandibulotomy. However, each of these approaches is associated with some complications. Endoscope-assisted minimally invasive surgery is being increasingly employed for surgeries in the head and neck regions. It has the advantage of leaving no facial scars, and ensures better patient comfort after the operation. Here, we report the use of endoscope-assisted trans-oral surgery for excision of parapharyngeal space tumors. The technique yields an excellent outcome and should be a feasible, safe, and economic method for these patients. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Were policies in Brazil effective to reducing trans fat from industrial origin in foods?

Science.gov (United States)

Dias, Flávia da Silva Lima; Lima, Mário Ferreira; Velasco, Patricia Coelho de; Salles-Costa, Rosana; Sardinha, Fátima Lúcia de Carvalho; Carmo, Maria das Graças Tavares do

2018-04-09

To determine the trans fatty acids content of processed foods frequently consumed by adults living in a Rio de Janeiro, Brazil, after the enactment of a mandatory trans fatty acids labelling policy. Between February 2014 and January 2015, a specifically dietary questionnaire was completed by 107 adults to assess the frequency of processed foods consumption. The most commonly consumed products from the survey, including vegetable oils, margarine, biscuits, snacks, cheese bread (pão de queijo), french fries, cheeseburger and ice cream, were then analyzed for their trans fatty acids content using gas chromatography with a flame ionization detector. Differences in the levels of trans fatty acids were observed among 22 products analyzed, considering that trans fatty acids content ranged between 0.0 g/100 g in samples of cream cracker biscuit 1 and olive oil to 0.83 g/100 g in samples of cheeseburger (fast food), 0.51 g/100 g in samples of frozen pão de queijo and 12.92 g/100 g in samples of chocolate sandwich cookies with cream filling 2. The overall trans fatty acids content of the different samples of margarine brands was 0.20 g/100 g for brand 1 and 0.0 g/100 g for brand 2. These data are significantly lower than those observed in a survey conducted in 2003, when the regulation had been enacted. Our data indicate that Brazilian regulation is very likely implicated in the observed drop in trans fatty acids of the most processed foods but has yet to eliminate them, which reinforces the urgent need to revise the legislation, since a minimum amount of trans fat does not mean that the food product does not contain this type of fat.

Were policies in Brazil effective to reducing trans fat from industrial origin in foods?

Directory of Open Access Journals (Sweden)

Flávia da Silva Lima Dias

2018-04-01

Full Text Available ABSTRACT OBJECTIVE To determine the trans fatty acids content of processed foods frequently consumed by adults living in a Rio de Janeiro, Brazil, after the enactment of a mandatory trans fatty acids labelling policy. METHODS Between February 2014 and January 2015, a specifically dietary questionnaire was completed by 107 adults to assess the frequency of processed foods consumption. The most commonly consumed products from the survey, including vegetable oils, margarine, biscuits, snacks, cheese bread (pão de queijo, french fries, cheeseburger and ice cream, were then analyzed for their trans fatty acids content using gas chromatography with a flame ionization detector. RESULTS Differences in the levels of trans fatty acids were observed among 22 products analyzed, considering that trans fatty acids content ranged between 0.0 g/100 g in samples of cream cracker biscuit 1 and olive oil to 0.83 g/100 g in samples of cheeseburger (fast food, 0.51 g/100 g in samples of frozen pão de queijo and 12.92 g/100 g in samples of chocolate sandwich cookies with cream filling 2. The overall trans fatty acids content of the different samples of margarine brands was 0.20 g/100 g for brand 1 and 0.0 g/100 g for brand 2. These data are significantly lower than those observed in a survey conducted in 2003, when the regulation had been enacted. CONCLUSIONS Our data indicate that Brazilian regulation is very likely implicated in the observed drop in trans fatty acids of the most processed foods but has yet to eliminate them, which reinforces the urgent need to revise the legislation, since a minimum amount of trans fat does not mean that the food product does not contain this type of fat.

Cis/trans Coordination in olefin metathesis by static and molecular dynamic DFT calculations

KAUST Repository

Poater, Albert; Correa, Andrea; Pump, Eva; Cavallo, Luigi

2014-01-01

In regard to [(N-heterocyclic carbene)Ru]-based catalysts, it is still a matter of debate if the substrate binding is preferentially cis or trans to the N-heterocyclic carbene ligand. By means of static and molecular dynamic DFT calculations, a simple olefin, like ethylene, is shown to be prone to the trans binding. Bearing in mind the higher reactivity of trans isomers in olefin metathesis, this insight helps to construct small alkene substrates with increased reactivity. © 2014 Springer Science+Business Media New York.

Cis/trans Coordination in olefin metathesis by static and molecular dynamic DFT calculations

KAUST Repository

Poater, Albert

2014-05-25

In regard to [(N-heterocyclic carbene)Ru]-based catalysts, it is still a matter of debate if the substrate binding is preferentially cis or trans to the N-heterocyclic carbene ligand. By means of static and molecular dynamic DFT calculations, a simple olefin, like ethylene, is shown to be prone to the trans binding. Bearing in mind the higher reactivity of trans isomers in olefin metathesis, this insight helps to construct small alkene substrates with increased reactivity. © 2014 Springer Science+Business Media New York.

Trans-methylation reactions in plants: focus on the activated methyl cycle.

Science.gov (United States)

Rahikainen, Moona; Alegre, Sara; Trotta, Andrea; Pascual, Jesús; Kangasjärvi, Saijaliisa

2018-02-01

Trans-methylation reactions are vital in basic metabolism, epigenetic regulation, RNA metabolism, and posttranslational control of protein function and therefore fundamental in determining the physiological processes in all living organisms. The plant kingdom is additionally characterized by the production of secondary metabolites that undergo specific hydroxylation, oxidation and methylation reactions to obtain a wide array of different chemical structures. Increasing research efforts have started to reveal the enzymatic pathways underlying the biosynthesis of complex metabolites in plants. Further engineering of these enzymatic machineries offers significant possibilities in the development of bio-based technologies, but necessitates deep understanding of their potential metabolic and regulatory interactions. Trans-methylation reactions are tightly coupled with the so-called activated methyl cycle (AMC), an essential metabolic circuit that maintains the trans-methylation capacity in all living cells. Tight regulation of the AMC is crucial in ensuring accurate trans-methylation reactions in different subcellular compartments, cell types, developmental stages and environmental conditions. This review addresses the organization and posttranslational regulation of the AMC and elaborates its critical role in determining metabolic regulation through modulation of methyl utilization in stress-exposed plants. © 2017 Scandinavian Plant Physiology Society.

Targeted Victimization and Suicidality Among Trans People: A Web-Based Survey.

Science.gov (United States)

Zeluf, Galit; Dhejne, Cecilia; Orre, Carolina; Mannheimer, Louise Nilunger; Deogan, Charlotte; Höijer, Jonas; Winzer, Regina; Thorson, Anna Ekéus

2018-04-01

The aim of this study was to investigate the associations between a series of empirically known risk and protective factors and suicidality among trans people in Sweden. Participants were self-selected anonymously to a web-based survey conducted in 2014. Univariable and multivariable logistic regression analyses were performed to assess associations between contributing factors and suicide ideation in the past 12 months and lifetime suicide attempts. The analysis included 796 trans individuals, between 15 and 94 years of age, who live in Sweden. A total of 37% of respondents reported that they have seriously considered suicide during the past 12 months and 32% had ever attempted a suicide. Offensive treatment during the past three months and lifetime exposure to trans-related violence were significantly associated with suicidality. Less satisfaction with contacts with friends and acquaintances and with one's own psychological wellbeing were associated with suicide ideation in the past 12 months. Lack of practical support was associated with lifetime suicide attempts. Our findings show that suicidality is directly correlated with trans-related victimization. Preventing targeted victimization is, therefore, a key preventive intervention against this elevated suicidality.

Landscape of the spliced leader trans-splicing mechanism in Schistosoma mansoni.

Science.gov (United States)

Boroni, Mariana; Sammeth, Michael; Gava, Sandra Grossi; Jorge, Natasha Andressa Nogueira; Macedo, Andréa Mara; Machado, Carlos Renato; Mourão, Marina Moraes; Franco, Glória Regina

2018-03-01

Spliced leader dependent trans-splicing (SLTS) has been described as an important RNA regulatory process that occurs in different organisms, including the trematode Schistosoma mansoni. We identified more than seven thousand putative SLTS sites in the parasite, comprising genes with a wide spectrum of functional classes, which underlines the SLTS as a ubiquitous mechanism in the parasite. Also, SLTS gene expression levels span several orders of magnitude, showing that SLTS frequency is not determined by the expression level of the target gene, but by the presence of particular gene features facilitating or hindering the trans-splicing mechanism. Our in-depth investigation of SLTS events demonstrates widespread alternative trans-splicing (ATS) acceptor sites occurring in different regions along the entire gene body, highlighting another important role of SLTS generating alternative RNA isoforms in the parasite, besides the polycistron resolution. Particularly for introns where SLTS directly competes for the same acceptor substrate with cis-splicing, we identified for the first time additional and important features that might determine the type of splicing. Our study substantially extends the current knowledge of RNA processing by SLTS in S. mansoni, and provide basis for future studies on the trans-splicing mechanism in other eukaryotes.

ELEVATED TRANS-MAMMARY TRANSMISSION OF Toxocara canis LARVAE IN BALB/c MICE

Directory of Open Access Journals (Sweden)

Paula de Lima Telmo

2015-02-01

Full Text Available Toxocariasis is a widespread zoonosis and is considered an important worldwide public health problem. The aim of this study was to investigate the frequency of trans-mammary Toxocara canis infection in newborn BALB/c mice nursed by females experimentally infected with 1,200 eggs after delivery. After 50 days of age, the presence of larvae in different organs of the offspring was investigated. Trans-mammary infection was confirmed in 73.9% of the mice that had been nursed by infected females. These data show a high trans-mammary transmission of T. canis and confirm the significance of this transmission route in paratenic hosts.

Detection of trans-cis flips and peptide-plane flips in protein structures

NARCIS (Netherlands)

Touw, W.G.; Joosten, R.P.; Vriend, G.

2015-01-01

A coordinate-based method is presented to detect peptide bonds that need correction either by a peptide-plane flip or by a trans-cis inversion of the peptide bond. When applied to the whole Protein Data Bank, the method predicts 4617 trans-cis flips and many thousands of hitherto unknown

Resisting Coherence: Trans Men's Experiences and the Use of Grounded Theory Methods

Science.gov (United States)

Catalano, D. Chase J.

2017-01-01

In this methodological reflective manuscript, I explore my decision to use a grounded theoretical approach to my dissertation study on trans* men in higher education. Specifically, I question whether grounded theory as a methodology is capable of capturing the complexity and capaciousness of trans*-masculine experiences. Through the lenses of…

Interdisciplinary research and trans-disciplinary validity claims

CERN Document Server

Gethmann, C F; Hanekamp, G; Kaiser, M; Kamp, G; Lingner, S; Quante, M; Thiele, F

2015-01-01

Interdisciplinarity has seemingly become a paradigm for modern and meaningful research. Clearly, the interdisciplinary modus of deliberation enables to unfold relevant but quite different disciplinary perspectives to the reflection of broader scientific questions or societal problems. However, whether the comprehensive results of interdisciplinary reflection prove to be valid or to be acceptable in trans-disciplinary terms depends upon certain preconditions, which have to be fulfilled for securing scientific quality and social trust in advisory contexts. The present book is written by experts and practitioners of interdisciplinary research and policy advice. It analyses topical and methodological approaches towards interdisciplinarity, starting with the current role of scientific research in society. The volume continues with contributions to the issues of knowledge and acting and to trans-disciplinary deliberation. The final conclusions address the scientific system as substantial actor itself as well as the...

Sequential analysis of trans-SNARE formation in intracellular membrane fusion.

Directory of Open Access Journals (Sweden)

Kannan Alpadi

2012-01-01

Full Text Available SNARE complexes are required for membrane fusion in the endomembrane system. They contain coiled-coil bundles of four helices, three (Q(a, Q(b, and Q(c from target (t-SNAREs and one (R from the vesicular (v-SNARE. NSF/Sec18 disrupts these cis-SNARE complexes, allowing reassembly of their subunits into trans-SNARE complexes and subsequent fusion. Studying these reactions in native yeast vacuoles, we found that NSF/Sec18 activates the vacuolar cis-SNARE complex by selectively displacing the vacuolar Q(a SNARE, leaving behind a Q(bcR subcomplex. This subcomplex serves as an acceptor for a Q(a SNARE from the opposite membrane, leading to Q(a-Q(bcR trans-complexes. Activity tests of vacuoles with diagnostic distributions of inactivating mutations over the two fusion partners confirm that this distribution accounts for a major share of the fusion activity. The persistence of the Q(bcR cis-complex and the formation of the Q(a-Q(bcR trans-complex are both sensitive to the Rab-GTPase inhibitor, GDI, and to mutations in the vacuolar tether complex, HOPS (HOmotypic fusion and vacuolar Protein Sorting complex. This suggests that the vacuolar Rab-GTPase, Ypt7, and HOPS restrict cis-SNARE disassembly and thereby bias trans-SNARE assembly into a preferred topology.

Transmutation of a trans-series: the Gross-Witten-Wadia phase transition

Science.gov (United States)

Ahmed, Anees; Dunne, Gerald V.

2017-11-01

We study the change in the resurgent asymptotic properties of a trans-series in two parameters, a coupling g 2 and a gauge index N, as a system passes through a large N phase transition, using the universal example of the Gross-Witten-Wadia third-order phase transition in the unitary matrix model. This transition is well-studied in the immediate vicinity of the transition point, where it is characterized by a double-scaling limit Painlevé II equation, and also away from the transition point using the pre-string difference equation. Here we present a complementary analysis of the transition at all coupling and all finite N, in terms of a differential equation, using the explicit Tracy-Widom mapping of the Gross-Witten-Wadia partition function to a solution of a Painlevé III equation. This mapping provides a simple method to generate trans-series expansions in all parameter regimes, and to study their transmutation as the parameters are varied. For example, at any finite N the weak coupling expansion is divergent, with a non-perturbative trans-series completion; on the other hand, the strong coupling expansion is convergent, and yet there is still a non-perturbative trans-series completion. We show how the different instanton terms `condense' at the transition point to match with the double-scaling limit trans-series. We also define a uniform large N strong-coupling expansion (a non-linear analogue of uniform WKB), which is much more precise than the conventional large N expansion through the transition region, and apply it to the evaluation of Wilson loops.

Trans women and Michfest: An ethnophenomenology of attendees' experiences.

Science.gov (United States)

McConnell, Elizabeth A; Odahl-Ruan, Charlynn A; Kozlowski, Christine; Shattell, Mona; Todd, Nathan R

2016-01-01

The rise of queer and transgender studies has greatly contributed to feminist and lesbian understandings of sex, gender, and sexuality and also has resulted in rifts, tensions, and border wars. One such tension is around the inclusion of trans women in women-only space, such as the Michigan Womyn's Music Festival (Michfest). In this ethnophenomenological study, we interviewed and surveyed 43 cisgender women who attended Michfest in 2013. Participants had a variety of perspectives on trans inclusion and on the dialogue surrounding it, and these paralleled intersections, frictions, and tensions between feminism, queer theory, and transgender studies.

Trans-fatty acid consumption and heart rate variability in two separate cohorts of older and younger adults

Science.gov (United States)

Soares-Miranda, Luisa; Stein, Phyllis K; Imamura, Fumiaki; Sattelmair, Jacob; Lemaitre, Rozenn N; Siscovick, David S; Mota, Jorge; Mozaffarian, Dariush

2014-01-01

Background Trans-fatty acid (TFA) consumption is associated with risk of coronary heart disease, and trans-18:2, but not trans-18:1, in red blood cells membranes has been associated with sudden cardiac arrest. Abnormal heart rate variability (HRV) reflects autonomic dysfunction and predicts cardiac death. Relationships between TFA consumption and HRV remain under-studied. We determined whether total TFA consumption, as well as trans-18:1 and trans-18:2 TFA consumption, were independently associated with HRV in two independent cohorts in the US and Portugal. Methods and Results In two independent cohorts of older US adults (Cardiovascular Health Study ([CHS], age=72±5yrs, 1989/1995) and young Portuguese adults (Porto, age=19±2yrs, 2008/2010), we assessed habitual TFA intake by food frequency questionnaires in CHS (separately estimating trans-18:1 and trans-18:2) and multiple 24-hour recalls in Porto (estimating total TFA only, which in a subset correlated with circulating trans-18:2, but not trans-18:1, suggesting that we captured the former). HRV was assessed using 24-hour Holters in CHS (N=1,076) and repeated short-term (5-min) ECGs in Porto (N=160). We used multivariate-adjusted linear regression to relate TFA consumption to HRV cross-sectionally (CHS, Porto) and longitudinally (CHS). In CHS, higher trans-18:2 consumption was associated with lower 24-hour standard-deviation-of-all-normal-to-normal-intervals (SDNN) both cross-sectionally (−12%, 95%CI=6–19%, p=0.001) and longitudinally (−15%, 95%CI=4–25 %, p= 0.009), and lower 24-hour SDANN and SDNN-index (pHRV, in particular time-domain indices (SDNN, SDANN, SDNN-index; pHRV in both older and young adults. Trans-18:1 consumption is associated with more favorable HRV indices in older adults. Our results support the need to investigate potential HRV related mechanisms whereby trans-18:2 may increase arrhythmic risk. PMID:22772898

Novel 9-cis/all-trans β-carotene isomerases from plastidic oil bodies in Dunaliella bardawil catalyze the conversion of all-trans to 9-cis β-carotene.

Science.gov (United States)

Davidi, Lital; Pick, Uri

2017-06-01

We identified and demonstrated the function of 9-cis/all-trans β-carotene isomerases in plastidic globules of Dunaliella bardawil, the species accumulating the highest levels of 9-cis β-carotene that is essential for humans. The halotolerant alga Dunaliella bardawil is unique in that it accumulates under light stress high levels of β-carotene in plastidic lipid globules. The pigment is composed of two major isomers: all-trans β-carotene, the common natural form of this pigment, and 9-cis β-carotene. The biosynthetic pathway of β-carotene is known, but it is not clear how the 9-cis isomer is formed. We identified in plastidic lipid globules that were isolated from D. bardawil two proteins with high sequence homology to the D27 protein-a 9-cis/all-trans β-carotene isomerase from rice (Alder et al. Science 335:1348-1351, 2012). The proteins are enriched in the oil globules by 6- to 17-fold compared to chloroplast proteins. The expression of the corresponding genes, 9-cis-βC-iso1 and 9-cis-βC-iso2, is enhanced under light stress. The synthetic proteins catalyze in vitro conversion of all-trans to 9-cis β-carotene. Expression of the 9-cis-βC-iso1 or of 9-cis-βC-iso2 genes in an E. coli mutant line that harbors β-carotene biosynthesis genes enhanced the conversion of all-trans into 9-cis β-carotene. These results suggest that 9-cis-βC-ISO1 and 9-cis-βC-ISO2 proteins are responsible for the formation of 9-cis β-carotene in D. bardawil under stress conditions.

Rigid nonproteinogenic cyclic amino acids as ligands for glutamate receptors: trans-tris(homoglutamic) acids

DEFF Research Database (Denmark)

Meyer, Udo; Bisel, Philippe; Bräuner-Osborne, Hans

2005-01-01

The second-generation asymmetric synthesis of the trans-tris(homoglutamic) acids reported herein proceeds via Strecker reaction of chiral ketimines, obtained from condensation of racemic 2-ethoxycarbonylmethylcyclopentanone and commercially available (S)- and (R)-1-phenylethylamine, respectively......) yielded diastereomeric mixtures of secondary alpha-amino amido-esters, which after separation were hydrogenolyzed and hydrolyzed each to the enantiomeric trans-1-amino-2-carboxymethylcyclopentanecarboxylic acids. Their configuration was completely established by NMR methods, CD spectra, and X-ray analysis...... of the trans-1S,2R-configured secondary alpha-amino amido-ester. In receptor binding assays and functional tests, trans-1S,2R-1-amino-2-carboxymethylcyclopentanecarboxylic acid hydrochloride was found to behave as a selective mGluR(2)-antagonist without relevant binding properties at iGluRs....

The trans-kingdom identification of negative regulators of pathogen hypervirulence.

Science.gov (United States)

Brown, Neil A; Urban, Martin; Hammond-Kosack, Kim E

2016-01-01

Modern society and global ecosystems are increasingly under threat from pathogens, which cause a plethora of human, animal, invertebrate and plant diseases. Of increasing concern is the trans-kingdom tendency for increased pathogen virulence that is beginning to emerge in natural, clinical and agricultural settings. The study of pathogenicity has revealed multiple examples of convergently evolved virulence mechanisms. Originally described as rare, but increasingly common, are interactions where a single gene deletion in a pathogenic species causes hypervirulence. This review utilised the pathogen-host interaction database (www.PHI-base.org) to identify 112 hypervirulent mutations from 37 pathogen species, and subsequently interrogates the trans-kingdom, conserved, molecular, biochemical and cellular themes that cause hypervirulence. This study investigates 22 animal and 15 plant pathogens including 17 bacterial and 17 fungal species. Finally, the evolutionary significance and trans-kingdom requirement for negative regulators of hypervirulence and the implication of pathogen hypervirulence and emerging infectious diseases on society are discussed. © FEMS 2015.

Synthesis through Trans-disciplinarity

DEFF Research Database (Denmark)

Hansen, Hanne Tine Ring

2006-01-01

synthesis is a requirement for creating successful ‘environmentally sustainable' architecture through the application of trans-disciplinarity, which leads to an increased awareness of the differences in decision-making as well as that of communication barriers between the different professions......When looking up the word ‘synthesis' in a dictionary, one comes across the following definition: "The combining of separate elements or substances to form a coherent whole."[1] Based on this definition one could argue that all great architectureis achieved through synthesis in one way or another...

Endoscopic versus microscopic trans-sphenoidal pituitary surgery: a systematic review and meta-analysis

NARCIS (Netherlands)

Goudakos, J. K.; Markou, K. D.; Georgalas, C.

2011-01-01

Endoscopic trans-sphenoidal surgery has been increasingly replacing microscopic surgery as the state of the art trans-sphenoidal approach. To assess the efficacy and safety of pure endoscopic approach in comparison with microscopic approach in pituitary surgery. Literature review and meta-analysis.

Trans fatty acid intake among the population of the city of São Paulo, Brazil Consumo de ácidos grasos trans en la población de la ciudad de Sao Paulo, Sureste de Brasil Consumo de ácidos graxos trans na população da cidade de São Paulo, Brasil

Directory of Open Access Journals (Sweden)

Michelle Alessandra de Castro

2009-12-01

Full Text Available OBJECTIVE: To analyze the monounsaturated and polyunsaturated trans fatty acid intake among the general population. METHODS: A cross-sectional study was conducted in São Paulo, Southeastern Brazil, in 2003, on a representative sample of 2,298 male and female subjects, including 803 adolescents (12 to 19 years, 713 adults (20 to 59 years and 782 elderly people (60 years or over. Food intake was measured using 24-hour recall. Mean trans fatty acid intake was described according to gender and age group. RESULTS: The mean trans fatty acid intake was 5.0 g/day (SE = 0.1, accounting for 2.4% (SE = 0.1 of total energy and 6.8% (SE = 0.1 of total lipids. The adolescents had the highest mean intake levels (7.4 g/day; 2.9% of energy while the adults and the elderly had similar intake (2.2% of energy for both; 6.4% of lipids and 6.5% of lipids, respectively. The mean trans fatty acid intake among adult and elderly women (approximately 2.5% of energy and 7.0% of lipids was higher than among men in the same age group. The food item with the highest contribution towards trans fatty acids was margarine, accounting for more than 30% of total intake, followed by filled cookies among adolescents and meat among adults and the elderly. CONCLUSIONS: The trans fatty acid intake is above the level recommended by the World Health Organization. Replacement of the trans fatty acids in manufactured food items may be an effective measure for reducing trans fatty acid intake in Brazil.OBJETIVO: Analizar el consumo de ácidos grasos moninsaturados y polinsaturados de configuración trans en la población general. MÉTODOS: Estudio transversal realizado en Sao Paulo, Sureste de Brasil, 2003, con muestra representativa de 2.298 individuos, siendo 803 adolescentes (12 a 19 años, 713 adultos (20 a 59 años y 782 ancianos (60 años o más, de ambos sexos. El consumo alimentario fue medido por medio del recordatorio alimentario de 24 horas. Los valores promedios de ingestión de

Structural Elucidation of cis / trans Dicaffeoylquinic Acid Photoisomerization Using Ion Mobility Spectrometry-Mass Spectrometry

Energy Technology Data Exchange (ETDEWEB)

Zheng, Xueyun; Renslow, Ryan S.; Makola, Mpho M.; Webb, Ian K.; Deng, Liulin; Thomas, Dennis G.; Govind, Niranjan; Ibrahim, Yehia M.; Kabanda, Mwadham M.; Dubery, Ian A.; Heyman, Heino M.; Smith, Richard D.; Madala, Ntakadzeni E.; Baker, Erin S.

2017-03-15

Due to the recently uncovered health benefits and anti-HIV activities of dicaffeoylquinic acids (diCQAs), understanding their structures and functions is of great interest for drug discovery efforts. DiCQAs are analytically challenging to identify and quantify since they commonly exist as a diverse mixture of positional and geometric (cis/trans) isomers. In this work, we utilized ion mobility spectrometry coupled with mass spectrometry to separate the various isomers before and after UV irradiation. The experimental collision cross sections were then compared with theoretical structures to differentiate and identify the diCQA isomers. Our analyses found that naturally the diCQAs existed predominantly as trans/trans isomers, but after 3 h of UV irradiation, cis/cis, cis/trans, trans/cis, and trans/trans isomers were all present in the mixture. This is the first report of successful differentiation of cis/trans diCQA isomers individually, which shows the great promise of IMS coupled with theoretical calculations for determining the structure and activity relationships of different isomers in drug discovery studies.

Cardiology Centre Patients’ Awareness of the Negative Effects of Trans Fatty Acids on Cardiovascular Diseases

Directory of Open Access Journals (Sweden)

Plociņa Lāsma

2017-12-01

Full Text Available It is very important to promote public awareness of the negative effects on health — trans fatty acid effects on cardiovascular disease. The study included 70 patients of the Latvian Centre of Cardiology, Pauls Stradiņš Clinical University Hospital (PSCUH. The PSCUH research institute gave permission to conduct the study. The patients answered questions about their awareness of trans fatty acids. The questionnaire used was obtained from the study “Use of Trans Fat Information on Food Labels and Its Determinants in a Multiethnic College Student Population” and modified for survey of the cardiology unit patients. The majority (74% of the respondents had heard and read something about trans fatty acids, but 62% women and 54% men were poorly informed about trans fatty acids and their negative effect on cardiovascular diseases. Unclear issues for patients were discussed after the questionnaire.

Crystallization and preliminary X-ray analysis of the bacillaene synthase trans-acting acyltransferase PksC

International Nuclear Information System (INIS)

Cuskin, Fiona; Solovyova, Alexandra S.; Lewis, Richard J.; Race, Paul R.

2011-01-01

The expression, purification and crystallization of the trans-acting acyltransferase PksC from the bacillaene hybrid polyketide synthase/nonribosomal peptide synthetase is described. The crystals belonged to the orthorhombic space group P2 1 2 1 2 1 and diffracted to 1.44 Å resolution. The antibiotic bacillaene is biosynthesized in Bacillus subtilis by a hybrid type 1 modular polyketide synthase/nonribosomal peptide synthetase of the trans-acyltransferase (trans-AT) class. Within this system, the essential acyl-group loading activity is provided by the action of three free-standing trans-acting acyltransferases. Here, the recombinant expression, purification and crystallization of the bacillaene synthase trans-acting acyltransferase PksC are reported. A diffraction data set has been collected from a single PksC crystal to 1.44 Å resolution and the crystal was found to belong to the orthorhombic space group P2 1 2 1 2 1

Attention modulates trans-saccadic integration.

Science.gov (United States)

Stewart, Emma E M; Schütz, Alexander C

2018-01-01

With every saccade, humans must reconcile the low resolution peripheral information available before a saccade, with the high resolution foveal information acquired after the saccade. While research has shown that we are able to integrate peripheral and foveal vision in a near-optimal manner, it is still unclear which mechanisms may underpin this important perceptual process. One potential mechanism that may moderate this integration process is visual attention. Pre-saccadic attention is a well documented phenomenon, whereby visual attention shifts to the location of an upcoming saccade before the saccade is executed. While it plays an important role in other peri-saccadic processes such as predictive remapping, the role of attention in the integration process is as yet unknown. This study aimed to determine whether the presentation of an attentional distractor during a saccade impaired trans-saccadic integration, and to measure the time-course of this impairment. Results showed that presenting an attentional distractor impaired integration performance both before saccade onset, and during the saccade, in selected subjects who showed integration in the absence of a distractor. This suggests that visual attention may be a mechanism that facilitates trans-saccadic integration. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Sodium 4-phenylbutyrate prevents murine dietary steatohepatitis caused by trans-fatty acid plus fructose.

Science.gov (United States)

Morinaga, Maki; Kon, Kazuyoshi; Saito, Hiroaki; Arai, Kumiko; Kusama, Hiromi; Uchiyama, Akira; Yamashina, Shunhei; Ikejima, Kenichi; Watanabe, Sumio

2015-11-01

Excess consumption of trans-fatty acid could increase the risk of non-alcoholic steatohepatitis (NASH); however, treatment targeting trans-fatty acid-induced NASH has not been examined. Here we focused on the influence of trans-fatty acid intake on endoplasmic reticulum (ER) stress in hepatocytes, so we investigated the effect of the chemical chaperone 4-phenylbutyric acid (PBA), on trans-fatty acid-caused steatohepatitis using diabetic KK-A(y) mice. Elaidic acid (EA, trans-fatty acid) alone did not cause definitive liver injury. In contrast, EA plus low-dose fructose induced extensive apoptosis in hepatocytes with severe fat accumulation. EA plus fructose significantly increased ER stress markers such as glucose-regulated protein 78 (GRP78), eukaryotic initiation factor 2α (eIF2α) and phosphorylated c-jun N-terminal kinase (JNK), while PBA significantly reduced this response. In vitro, EA promoted expression of GRP78 and phosphorylation of eIF2α in primary-cultured hepatocytes. EA also increased hepatocellular susceptibility to low-dose tert-butyl hydroperoxide. Treatment with PBA significantly reduced these responses. In conclusion, EA potentiates susceptibly to non-hazardous dose of fructose, and increases ER and oxidative stress. PBA improved steatohepatitis induced by EA plus fructose through amelioration of ER stress. Therefore, ER stress-targeted therapy using a chemical chaperone is a promising novel strategy for trans-fatty acid-induced steatohepatitis.

The Lauricella functions and exact string scattering amplitudes

International Nuclear Information System (INIS)

Lai, Sheng-Hong; Lee, Jen-Chi; Yang, Yi

2016-01-01

We discover that the 26D open bosonic string scattering amplitudes (SSA) of three tachyons and one arbitrary string state can be expressed in terms of the D-type Lauricella functions with associated SL(K+3,ℂ) symmetry. As a result, SSA and symmetries or relations among SSA of different string states at various limits calculated previously can be rederived. These include the linear relations first conjectured by Gross http://dx.doi.org/10.1016/0370-2693(87)90355-8; http://dx.doi.org/10.1016/0550-3213(88)90390-2; http://dx.doi.org/10.1103/PhysRevLett.60.1229D.J. Gross and J.R. Ellis, Strings at superplanckian energies: in search of the string symmetry, Phil. Trans. Roy. Soc. Lond. A 329 (1989) 401. http://dx.doi.org/10.1016/0550-3213(89)90435-5 and later corrected and proved in http://dx.doi.org/10.1016/j.physletb.2005.02.034; http://arxiv.org/abs/hep-th/0303012; http://dx.doi.org/10.1016/j.nuclphysb.2004.04.022; http://dx.doi.org/10.1016/j.nuclphysb.2004.11.032; http://dx.doi.org/10.1103/PhysRevLett.96.171601; http://dx.doi.org/10.1016/j.nuclphysb.2005.07.018; http://dx.doi.org/10.1016/j.nuclphysb.2005.12.025 in the hard scattering limit, the recurrence relations in the Regge scattering limit with associated SL(5,ℂ) symmetry http://dx.doi.org/10.1088/1126-6708/2009/06/028; http://dx.doi.org/10.1007/JHEP04(2013)082; http://dx.doi.org/10.1016/j.physletb.2014.11.017 and the extended recurrence relations in the nonrelativistic scattering limit with associated SL(4,ℂ) symmetry http://dx.doi.org/10.1007/JHEP05(2016)186 discovered recently. Finally, as an application, we calculate a new recurrence relation of SSA which is valid for all energies.

Lightlike Hypersurfaces in Indefinite Trans-Sasakian Manifolds

International Nuclear Information System (INIS)

Massamba, Fortune

2010-07-01

This paper deals with lightlike hypersurfaces of indefinite trans-Sasakian manifolds of type (α, β), tangent to the structure vector field. Characterization Theorems on parallel vector fields, integrable distributions, minimal distributions, Ricci-semi symmetric, geodesibility of lightlike hypersurfaces are obtained. The geometric configuration of lightlike hypersurfaces is established. We prove, under some conditions, that there are no parallel and totally contact umbilical lightlike hypersurfaces of trans-Sasakian space forms, tangent to the structure vector field. We show that there exists a totally umbilical distribution in an Einstein parallel lightlike hypersurface which does not contain the structure vector field. We characterize the normal bundle along any totally contact umbilical leaf of an integrable screen distribution. We finally prove that the geometry of any leaf of an integrable distribution is closely related to the geometry of a normal bundle and its image under φ-bar. (author)

Introduction to Trans Australia Airlines CRM training

Science.gov (United States)

Davidson, Jim

1987-01-01

Trans Australia believes that its excellent accident rate record is due to a number of factors. It has a good group of standard operating procedures, and its crews are pretty well self-disciplined and adhere to those procedures. But the other thing that it believes is a factor in its safety record is that perhaps it is also due to its preparedness to be innovative, to keep up with what is going on in the rest of the world and, if it looks to have value, then to be amongst the first to try it out. Trans Australia commenced a program similar to Line Oriented Flight Training (LOFT) fairly early in 1979--that being its first windshear program-- which leads to why they are doing a course of resource management training, which we have chosen to call Aircrew Team Management (ATM). This course is detailed in another presentation.

Corrosion of silicon-containing austenitic stainless steels under trans-passive conditions

International Nuclear Information System (INIS)

Stolarz, Jacek

1989-01-01

This research thesis addresses austenitic stainless steels which are used in installations for the chemical treatment of nuclear fuels, and are there in contact with nitric acid solutions the oxidising character of which generally promotes metal passivity. However, if this nitric environment becomes too oxidising, these steels may face severe corrosion problems. More particularly, this thesis addresses the study of intergranular corrosion, and aims at analysing various aspects of the corrosion of these austenitic stainless steels in trans-passive conditions. The author aims at determining and distinguishing the contributions due to silicon and those related to the presence of other impurities and addition elements by comparing the behaviours of industrial grade steels and high purity alloys in rigorously controlled electrochemical conditions. Another objective is to study the influence of the intergranular structure on silicon segregation by means of an attack technique in trans-passive conditions. After a report of a bibliographical study on the addressed topics and a presentation of the studied materials and implemented experimental techniques, the author reports the study of steel behaviour with respect to generalised dissolution in trans-passive conditions, as well in the nitric environment as in a sulphuric acid solution at imposed potential. Localised intragranular corrosion phenomena are discussed. A trans-passive intragranular corrosion model is proposed, and its possibilities in the analysis of intergranular segregation analysis are discussed. Experimental results of trans-passive intergranular corrosion of stainless steels are presented and interpreted by using the McLean segregation model. The influence of steel composition and of experimental conditions is discussed, as well as the role of grain boundary structure in the corrosion process [fr

Sociodemographic Variables, Clinical Features, and the Role of Preassessment Cross-Sex Hormones in Older Trans People.

Science.gov (United States)

Bouman, Walter Pierre; Claes, Laurence; Marshall, Ellen; Pinner, Gill T; Longworth, Julia; Maddox, Victoria; Witcomb, Gemma; Jimenez-Murcia, Susana; Fernandez-Aranda, Fernando; Arcelus, Jon

2016-04-01

As referrals to gender identity clinics have increased dramatically over the last few years, no studies focusing on older trans people seeking treatment are available. The aim of this study was to investigate the sociodemographic and clinical characteristics of older trans people attending a national service and to investigate the influence of cross-sex hormones (CHT) on psychopathology. Individuals over the age of 50 years old referred to a national gender identity clinic during a 30-month period were invited to complete a battery of questionnaires to measure psychopathology and clinical characteristics. Individuals on cross-sex hormones prior to the assessment were compared with those not on treatment for different variables measuring psychopathology. Sociodemographic and clinical variables and measures of depression and anxiety (Hospital Anxiety and Depression Scale), self-esteem (Rosenberg Self-Esteem Scale), victimization (Experiences of Transphobia Scale), social support (Multidimensional Scale of Perceived Social Support), interpersonal functioning (Inventory of Interpersonal Problems), and nonsuicidal self-injury (Self-Injury Questionnaire). The sex ratio of trans females aged 50 years and older compared to trans males was 23.7:1. Trans males were removed for the analysis due to their small number (n = 3). Participants included 71 trans females over the age of 50, of whom the vast majority were white, employed or retired, and divorced and had children. Trans females on CHT who came out as trans and transitioned at an earlier age were significantly less anxious, reported higher levels of self-esteem, and presented with fewer socialization problems. When controlling for socialization problems, differences in levels of anxiety but not self-esteem remained. The use of cross-sex hormones prior to seeking treatment is widespread among older trans females and appears to be associated with psychological benefits. Existing barriers to access CHT for older trans

Reference values of urinary trans,trans-muconic acid: Italian Multicentric Study.

Science.gov (United States)

Aprea, C; Sciarra, G; Bozzi, N; Pagliantini, M; Perico, A; Bavazzano, P; Leandri, A; Carrieri, M; Scapellato, M L; Bettinelli, M; Bartolucci, G B

2008-08-01

This article reports the results of a study, conducted in the framework of the scientific activities of the Italian Society for Reference Values, aimed at defining reference values of urinary trans,trans-muconic acid (t,t-MA) in the general population not occupationally exposed to benzene. t,t-MA concentrations detected in 376 subjects of the resident population in three areas of Italy, two in central (Florence and southern Tuscany) and one in northern Italy (Padua), by three laboratories, compared by repeated interlaboratory controls, showed an interval of 14.4-225.0 microg/L (5th-95th percentile) and a geometric mean of 52.5 microg/L. The concentrations measured were influenced by tobacco smoking in a statistically significant way: Geometric mean concentrations were 44.8 microg/L and 76.1 microg/Ll in nonsmokers (264 subjects) and smokers (112 subjects), respectively. In the nonsmoking population, a significant influence of gender was found when concentrations were corrected for urinary creatinine, geometric mean concentrations being 36.7 microg/g creatinine in males (128 subjects) and 44.7 microg/g creatinine in females (136 subjects). The place of residence of subjects did not seem to influence urinary excretion of the metabolite, although personal inhalation exposure to benzene over a 24-h period showed slightly higher concentrations in Padua and Florence (geometric means of 6.5 microg/m(3) and 6.6 microg/m(3), respectively) than in southern Tuscany (geometric mean of 3.9 microg/m(3)). Concentration of t,t-MA in urine samples collected at the end of personal air sampling showed little relationship to personal inhalation exposure to benzene, confirming the importance of other factors in determining excretion of t,t-MA when concentrations in personal air samples are very low.

Trans-triquetral Perilunate fracture dislocation

OpenAIRE

John-Henry Rhind; Abhinav Gulihar; Andrew Smith

2018-01-01

Perilunate dislocations and perilunate fracture dislocations are rare and serious injuries. Perilunate dislocations represent less than 10% of all carpal injuries of which 61% represent transcaphoid fractures. Because of their rarity, up to 25% of perilunate dislocations are initially missed on first assessment. We present the case of a 66-year-old-gentleman who sustained an isolated trans-triquetral perilunate fracture dislocation while walking his dog. This was diagnosed in the emergency de...

trans-2-Tritylcyclohexanol as a chiral auxiliary in permanganate-mediated oxidative cyclization of 2-methylenehept-5-enoates: application to the synthesis of trans-(+)-linalool oxide.

Science.gov (United States)

Al Hazmi, Ali M; Sheikh, Nadeem S; Bataille, Carole J R; Al-Hadedi, Azzam A M; Watkin, Sam V; Luker, Tim J; Camp, Nicholas P; Brown, Richard C D

2014-10-03

The permanganate-mediated oxidative cyclization of a series of 2-methylenehept-5-eneoates bearing different chiral auxiliaries was investigated, leading to the discovery of trans-2-tritylcyclohexanol (TTC) as a highly effective chiral controller for the formation of the 2,5-substituted THF diol product with high diastereoselectivity (dr ∼97:3). Chiral resolution of (±)-TTC, prepared in one step from cyclohexene oxide, afforded (-)-(1S,2R)-TTC (er >99:1), which was applied to the synthesis of (+)-trans-(2S,5S)-linalool oxide.

Trans-umbilical Laparoscopic Appendectomy for Acute Appendicitis ...

African Journals Online (AJOL)

Trans-umbilical Laparoscopic Appendectomy for Acute Appendicitis without Raising Skin-flaps: An Easy-to-use Modification Applied to the Series of 164 Patients from a Rural Institute of Central India. Priyadarshan Anand Jategaonkar, Sudeep Pradeep Yadav1. INTRODUCTION. Laparoscopic appendectomy (LA) is widely ...

Carnivore-caused livestock mortality in Trans-Himalaya

NARCIS (Netherlands)

Namgail, T.; Fox, J.L.; Bhatnagar, Y.V.

2007-01-01

The loss of livestock to wild predators is an important livelihood concern among Trans-Himalayan pastoralists. Because of the remoteness and inaccessibility of the region, few studies have been carried out to quantify livestock depredation by wild predators. In the present study, we assessed the

Distribution of trans-resveratrol and its metabolites after acute or sustained administration in mouse heart, brain, and liver.

Science.gov (United States)

Menet, Marie-Claude; Baron, Stephanie; Taghi, Meryam; Diestra, Remi; Dargère, Delphine; Laprévote, Olivier; Nivet-Antoine, Valérie; Beaudeux, Jean-Louis; Bédarida, Tatiana; Cottart, Charles-Henry

2017-08-01

Trans-resveratrol is widely studied for its potentially beneficial effects on numerous disorders. It is rapidly metabolized and its metabolites can exhibit biological activity. The present study aimed to investigate whether acute or sustained trans-resveratrol administration impacted on the distribution of trans-resveratrol and its metabolites in brain, heart, and liver. We used ultra-HPLC quadrupole-TOF (UHPLC-Q-TOF) in a full-scan mode to identify and assess large numbers of resveratrol metabolites. For acute intake, mice were overfed with a single dose of trans-resveratrol (150 mg/kg) and organs were collected after 30 and 60 min. For sustained intake, trans-resveratrol was given in the chow (0.04% w/w corresponding to 40 mg/kg/day), and plasma and the organs were collected after 3 months of this resveratrol diet. We found that trans-resveratrol-3-O-glucuronide and resveratrol-3-sulfate were the main metabolites found after acute intake, and free trans-resveratrol (in the brain and heart) and dihydroresveratrol derivatives were found after sustained administration CONCLUSIONS: Our results show notable differences between acute and sustained administration of trans-resveratrol and distribution of trans-resveratrol and its metabolites in mouse heart, brain, and liver. The results suggest a strategy for development of galenic forms of resveratrol. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Effect of ultrasonic waves on the stability of all-trans lutein and its degradation kinetics.

Science.gov (United States)

Song, Jiang-Feng; Li, Da-Jing; Pang, Hui-Li; Liu, Chun-Quan

2015-11-01

Ultrasound treatment has been widely applied in the extraction of biologically active compounds including carotenoids. However, there are few reports on their effects on the stability of these compounds. In the present study, the stability of all-trans lutein, one of the carotenoids, was investigated under the action of ultrasound. Results showed that ultrasound induced the isomerization of all-trans lutein to its isomers, namely to 13-cis lutein, 13'-cis lutein, 9-cis lutein and 9'-cis lutein as analyzed by HPLC coupled with DAD and LC-MS; and the percentage of the isomerization increased with increasing both ultrasonic frequency and power. The stability of all-trans lutein in dichloromethane was worst among multiple kinds of solvents. Interestingly, the retention rate of all-trans lutein improved as the temperature increased, which runs counter to the Arrhenius law. Under ultrasound irradiation, the degradation mechanism might be different with various temperatures, the degradation of all-trans lutein followed first-order kinetics at 20°C, while second-order kinetics was followed at 30-50°C. As the ultrasonic reaction time prolonged, lutein epoxidation nearly occurred. Those results presented here emphasized that UAE techniques should be carefully used in the extraction of all-trans lutein. Copyright © 2015 Elsevier B.V. All rights reserved.

Calderas and mineralization: volcanic geology and mineralization in the Chianti caldera complex, Trans-Pecos Texas

Energy Technology Data Exchange (ETDEWEB)

Duex, T.W.; Henry, C.D.

1981-01-01

This report describes preliminary results of an ongoing study of the volcanic stratigraphy, caldera activity, and known and potential mineralization of the Chinati Mountains area of Trans-Pecos Texas. Many ore deposits are spatially associated with calderas and other volcanic centers. A genetic relationship between calderas and base and precious metal mineralization has been proposed by some and denied by others. Steven and others have demonstrated that calderas provide an important setting for mineralization in the San Juan volcanic field of Colorado. Mineralization is not found in all calderas but is apparently restricted to calderas that had complex, postsubsidence igneous activity. A comparison of volcanic setting, volcanic history, caldera evolution, and evidence of mineralization in Trans-Pecos to those of the San Juan volcanic field, a major mineral producer, indicates that Trans-Pecos Texas also could be an important mineralized region. The Chianti caldera complex in Trans-Pecos Texas contains at least two calderas that have had considerable postsubsidence activity and that display large areas of hydrothermal alteration and mineralization. Abundant prospects in Trans-Pecos and numerous producing mines immediately south of the Trans-Pecos volcanic field in Mexico are additional evidence that ore-grade deposits could occur in Texas.

'Homens trans': novos matizes na aquarela das masculinidades? 'Trans men': new colours in the masculinities picture?

Directory of Open Access Journals (Sweden)

Guilherme Almeida

2012-08-01

Full Text Available O artigo discute de forma exploratória a emergência de uma nova categoria identitária no Brasil, a de 'homem trans'. Essa se constrói diferenciando-se da identidade lésbica e, também, de expressões de gênero de outros grupos que tiveram seus corpos assignados como femininos ao nascimento, mas que contestam essa assignação sem, contudo, se afirmarem 'homens' de forma constante. Afirma-se que a emergência dos 'homens trans' tem sido potencializada pelo estabelecimento do processo transexualizador no SUS. Discutem-se o uso do termo "homem trans" e algumas características comuns a tais sujeitos. Problematizam-se a complexidade de seus processos de autorreconhecimento e construção de masculinidades, sua rápida capacidade de indiferenciação a partir de modificações corporais e, alguns dos efeitos políticos e subjetivos, da visibilidade e da indiferenciação.The article discusses in an exploratory form the emergence of a new identity category in Brazil, namely "transmen". This identity is constructed as a differentiation from the lesbian identity and also from gender expressions of other groups that had their bodies assigned as female upon birth, but that later refuted this assignment without, however, affirming themselves as "men" on a permanent way. The article claims that the emergence of "transmen" has been made possible by the establishment of the transexualization process in the Public Health Care System. Furthermore, the article discusses the use of the term "transman" and some common characteristics related to those persons. The author critiques their complex processes of self-knowledge and construction of masculinities, as well as their quick capacity for non-differentiation from the stand-point of bodily modifications. Finally, the author discusses the political and subjective consequences of their visibility and non-differentiation.

Effects of SMILE and Trans-PRK on corneal higher order aberrations after myopic correction

Directory of Open Access Journals (Sweden)

Jiao Zhao

2018-02-01

Full Text Available AIM:To observe the effects of small incision lenticule extraction(SMILEand trans-epithelial photorefractive keratectomy(Trans-PRKon corneal horizontal coma, vertical coma, and spherical aberration and total higher order aberrations after refractive correction for myopia. METHODS: This was a prospective non-randomized cohort study. The cohort included 40 patients(80 eyeswith myopia, who received refraction correction surgery from December 2016 to February 2017 in Leshan Ophthalmic Center. Twenty patients(40 eyesreceived SMILE surgery and the other 20 patients(40 eyesreceived Trans-PRK surgery. Corneal aberrations were determined by a high-resolution Pentacam Scheimpflug camera before the surgery and at 1 and 3mo after the operation. Statistical analyses were performed using analysis of variance of repeated measures. RESULTS: At 1 and 3mo post-operation, the uncorrected visual acuity in both groups was better than or equal to the preoperative best corrected visual acuity. The preoperative corneal aberrations showed no significant difference between the two groups(P>0.05. Significantly higher aberration was found after the surgery in both groups(PP>0.05. Post-operation, horizontal and vertical coma had no significant difference between the two groups(P>0.05, while SMILE group showed lower spherical aberration and lower total higher order aberration than Trans-PRK group(PCONCLUSION: Both SMILE and Trans-PRK increase corneal aberration and their effects on horizontal and vertical coma are similar. However, SMILE has a minor influence on spherical aberration and total high order aberration than Trans-PRK.

Improvement of arbutin trans-epidermal delivery using ...

African Journals Online (AJOL)

Purpose: To assess the ability of radiofrequency (RF) microporation to promote trans-epidermal delivery of arbutin. Methods: To investigate the enhancing effect of RF microchannels on skin permeation of arbutin, in vitro skin permeability studies were performed with RF microporation-treated Hartley albino guinea pig skin ...

Chronic consumption of trans fat can facilitate the development of hyperactive behavior in rats.

Science.gov (United States)

Pase, C S; Roversi, Kr; Trevizol, F; Kuhn, F T; Dias, V T; Roversi, K; Vey, L T; Antoniazzi, C T; Barcelos, R C S; Bürger, M E

2015-02-01

In recent decades, the increased consumption of processed foods, which are rich in hydrogenated vegetable fat (HVF), has led to a decreased consumption of fish and oilseed, rich in omega-3 fatty acids. This eating habit provides an increased intake of trans fatty acids (TFA), which may be related to neuropsychiatric conditions, including inattention and hyperactivity. In this study, we evaluated the potential connection between prolonged trans fat consumption and development of hyperactivity-like symptoms in rats using different behavioral paradigms. Trans fat intake for 10 months (Experiment 1), as well as during pregnancy and lactation across two sequential generations of rats, (Experiment 4) induced active coping in the forced swimming task (FST). In addition, HVF supplementation was associated with increased locomotion before and after amphetamine (AMPH) administration (Experiment 2). Similarly, HVF supplementation during pregnancy and lactation were associated with increased locomotion in both young and adult rats (Experiment 3). Furthermore, trans fat intake across two sequential generations increased locomotor and exploratory activities following stressors (Experiment 4). From these results, we suggest that chronic consumption of trans fat is able to enhance impulsiveness and reactivity to novelty, facilitating hyperactive behaviors. Copyright © 2014 Elsevier Inc. All rights reserved.

Formation of trans fatty acids during the frying of chicken fillet in corn oil.

Science.gov (United States)

Yang, Meiyan; Yang, Ying; Nie, Shaoping; Xie, Mingyong; Chen, Feng; Luo, Pengju George

2014-05-01

To assess effects of heated edible oils on intake of trans fatty acids (TFAs); the formation of TFAs in cooking conditions was investigated by a frying system model, in which chicken fillet was fried in a commercial corn oil at 170 °C, for 12 frying cycles. The main TFAs detected in chicken fillet were trans C18:2 fatty acids (FAs) and trans C18:3 FAs, which exhibited no significant differences among the frying cycles. Besides, the content of trans C18:1 FAs were very low in all samples on different frying cycles. The intake of TFAs was estimated to be 0.06 g/100 g when chicken fillet fried in this process was consumed. These results suggest that an ordinary frying process upon a commercial corn oil has little impact on the daily TFAs intake.

Breaking down barriers: exploring the potential for social care practice with trans survivors of domestic abuse.

Science.gov (United States)

Rogers, Michaela

2016-01-01

There is increasing recognition that domestic abuse takes place outside the heteronormative paradigm of social life. This paper presents a discussion of the findings of doctoral research which explores trans people's experiences of domestic abuse, their social care needs and whether these are met by domestic abuse agencies. This paper foregrounds debate on the intersections of domestic abuse, trans communities and social care provision as this research, and previous studies, suggests that trans survivors do not seek out or benefit from social care intervention. Qualitative data, collected via narrative interviews, were collected during 2012 from participants mainly located in the United Kingdom (two participants were based in the United States). A total of 24 interviews were undertaken with trans people (n = 15) and social care practitioners (n = 9). Data were examined using a voice-centred relational technique. The findings reveal that barriers are multiple and complex but work could be undertaken to encourage help-seeking behaviours. Barriers include expectations of a transphobic response and 'Othering' practices; lack of entitlement felt by trans people; lack of knowledge/misunderstandings about trans social care needs; heteronormative bias of existing services; and practitioner attitudes fixed to notions about gender as binary. The paper ends by proposing a framework for practice with trans survivors which incorporates a person-centred, narrative approach. © 2015 John Wiley & Sons Ltd.

Fatty acids trans profile of oil and hidrogenated soy fat in frying process

OpenAIRE

Sanibal, Elaine Abrão Assef; Mancini Filho, Jorge

2004-01-01

O objetivo desse estudo foi avaliar as alterações dos ácidos graxos e a formação de isômeros trans, durante o aquecimento de óleo de soja (OS) e gordura parcialmente hidrogenada de soja (GPHS) no processo de fritura de batata por 100 horas com reposição lipídica. O perfil de ácidos graxos foi avaliado através de cromatografia gasosa em coluna capilar de 100m. Os ácidos graxos monoinsaturados trans foram os predominantes entre os isômeros trans. A partir de 10 horas de fritura, o OS formou 2,1...

Synthesis of (+-)-[1,1'-15N2, 2'-13C]-trans-3'-methylnicotine

International Nuclear Information System (INIS)

Sirimanne, S.R.; Maggio, V.L.; Patterson, D.G. Jr.

1992-01-01

The synthesis of (±)- [1,1'- 15 N 2 , 2'- 13 C]-trans-3'-methylnicotine is reported. 15 N-3-Bromopyridine obtained from bromination of pyridine was formylated with nBuLi/[carbonyl- 13 C]-methyl formate. The resulting 15 n-Pyridine-3-[ 13 C-carbonyl]-carboxaldehyde was reacted with 15 N-methylamine and then the resulting Schiff's base was condensed with succinic anhydride to give (±)- [1,1'- 15 N 2 , 5'- 13 C]-trans-4'-carboxycotinine. Reduction with lithium aluminum hydride and mesylation followed by reduction with Zn/NaI gave (±)-[1,1'- 15 N 2 , 2'- 13 C]-trans-3'-methylnicotine. (Author)

Trans-complex formation by proteolipid channels in the terminal phase of membrane fusion

DEFF Research Database (Denmark)

Peters, C; Bayer, M J; Bühler, S

2001-01-01

-complex formation occurs downstream from trans-SNARE pairing, and depends on both the Rab-GTPase Ypt7 and calmodulin. The maintenance of existing complexes and completion of fusion are independent of trans-SNARE pairs. Reconstituted proteolipids form sealed channels, which can expand to form aqueous pores in a Ca2...

TransDetect Identifies a New Regulatory Module Controlling Phosphate Accumulation.

Science.gov (United States)

Pal, Sikander; Kisko, Mushtak; Dubos, Christian; Lacombe, Benoit; Berthomieu, Pierre; Krouk, Gabriel; Rouached, Hatem

2017-10-01

Identifying transcription factor (TFs) cooperation controlling target gene expression is still an arduous challenge. The accuracy of current methods at genome scale significantly drops with the increase in number of genes, which limits their applicability to more complex genomes, like animals and plants. Here, we developed an algorithm, TransDetect, able to predict TF combinations controlling the expression level of a given gene. TransDetect was used to identify novel TF modules regulating the expression of Arabidopsis ( Arabidopsis thaliana ) phosphate transporter PHO1;H3 comprising MYB15, MYB84, bHLH35, and ICE1. These TFs were confirmed to interact between themselves and with the PHO1;H3 promoter. Phenotypic and genetic analyses of TF mutants enable the organization of these four TFs and PHO1;H3 in a new gene regulatory network controlling phosphate accumulation in zinc-dependent manner. This demonstrates the potential of TransDetect to extract directionality in nondynamic transcriptomes and to provide a blueprint to identify gene regulatory network involved in a given biological process. © 2017 American Society of Plant Biologists. All Rights Reserved.

Trans-European transport networks and urban systems in European Union

Directory of Open Access Journals (Sweden)

Maksin-Mićić Marija

2003-01-01

Full Text Available The trans-European transport network has different effects at interregional macro-regional and mezzo-regional level, and its effectiveness rises at the lower regional levels. Possible approaches to the trans-European transport network impact and effect survey and policy options have been pointed out. In that respect the brief review of survies, strategic framework and policies in European Union has been given. The importance of increased accessibility and mobility for regional expansion and for more balanced and polycentric system of city networks has been underlined. The question is how the new major transport infrastructure affects the development of functional complementarity between cities and regions. The new trans-European or major transport infrastructure does not per se create regional and urban system network development, although it can affect the conditions for the processes that create growth and development. The effects can be increased by co-ordination of measures of regional and urban policy, land use, transport and other policies. The necessary measure is the introduction of spatial impact assessment as sectorial policy instrument for the large transport infrastructure projects.

Quantum generalized observables framework for psychological data: a case of preference reversals in US elections

Science.gov (United States)

Khrennikova, Polina; Haven, Emmanuel

2017-10-01

Politics is regarded as a vital area of public choice theory, and it is strongly relying on the assumptions of voters' rationality and as such, stability of preferences. However, recent opinion polls and real election outcomes in the USA have shown that voters often engage in `ticket splitting', by exhibiting contrasting party support in Congressional and Presidential elections (cf. Khrennikova 2014 Phys. Scripta T163, 014010 (doi:10.1088/0031-8949/2014/T163/014010); Khrennikova & Haven 2016 Phil. Trans. R. Soc. A 374, 20150106 (doi:10.1098/rsta.2015.0106); Smith et al. 1999 Am. J. Polit. Sci. 43, 737-764 (doi:10.2307/2991833)). Such types of preference reversals cannot be mathematically captured via the formula of total probability, thus showing that voters' decision making is at variance with the classical probabilistic information processing framework. In recent work, we have shown that quantum probability describes well the violation of Bayesian rationality in statistical data of voting in US elections, through the so-called interference effects of probability amplitudes. This paper is proposing a novel generalized observables framework of voting behaviour, by using the statistical data collected and analysed in previous studies by Khrennikova (Khrennikova 2015 Lect. Notes Comput. Sci. 8951, 196-209) and Khrennikova & Haven (Khrennikova & Haven 2016 Phil. Trans. R. Soc. A 374, 20150106 (doi:10.1098/rsta.2015.0106)). This framework aims to overcome the main problems associated with the quantum probabilistic representation of psychological data, namely the non-double stochasticity of transition probability matrices. We develop a simplified construction of generalized positive operator valued measures by formulating special non-orthonormal bases with respect to these operators. This article is part of the themed issue `Second quantum revolution: foundational questions'.

New York City trans fat ban: improving the default option when purchasing foods prepared outside the home

Science.gov (United States)

The adverse effects of trans fatty acid (trans fat) on cardiovascular health have been known for at least 2 decades. During that time, both the Dietary Guidelines for Americans and the Institute of Medicine’s Dietary Reference Intake guidelines have recommended restricting trans fat intake to the ex...

Challenges of implementing collaborative models of decision making with trans-identified patients.

Science.gov (United States)

Dewey, Jodie M

2015-10-01

Factors health providers face during the doctor-patient encounter both impede and assist the development of collaborative models of treatment. I investigated decision making among medical and therapeutic professionals who work with trans-identified patients to understand factors that might impede or facilitate the adoption of the collaborative decision-making model in their clinical work. Following a grounded theory approach, I collected and analysed data from semi-structured interviews with 10 U.S. physicians and 10 U.S. mental health professionals. Doctors and therapists often desire collaboration with their patients but experience dilemmas in treating the trans-identified patients. Dilemmas include lack of formal education, little to no institutional support and inconsistent understanding and application of the main documents used by professionals treating trans-patients. Providers face considerable risk in providing unconventional treatments due to the lack of institutional and academic support relating to the treatment for trans-people, and the varied interpretation and application of the diagnostic and treatment documents used in treating trans-people. To address this risk, the relationship with the patient becomes crucial. However, trust, a component required for collaboration, is thwarted when the patients feel obliged to present in ways aligned with these documents in order to receive desired treatments. When trust cannot be established, medical and mental health providers can and do delay or deny treatments, resulting in the imbalance of power between patient and provider. The documents created to assist in treatment actually thwart professional desire to work collaboratively with patients. © 2013 John Wiley & Sons Ltd.

Dexmedetomidine could enhance surgical satisfaction in Trans-sphenoidal resection of pituitary adenoma.

Science.gov (United States)

Salimi, Alireza; Sharifi, Guive; Bahrani, Houshang; Mohajerani, Seyed A; Jafari, Alireza; Safari, Farhad; Jalessi, Maryam; Mirkheshti, Alireza; Mottaghi, Kamran

2017-02-01

Excessive bleeding is an unwanted complication of trans-sphenoidal resection of pituitary adenoma due to increases in intracranial pressure (ICP) and hemodynamic instability. Dexmedetomidine (Dex) anα2-agonists is the drug of choice in intensive care units (ICU) and cardiac surgeries to control abrupt changes in hemodynamic. Severe cardiovascular responses occur during trans-sphenoidal resection (TSR) of the pituitary adenoma despite adequate depth of anesthesia. The aim of this paper was to determine the effect of Dexmedetomidine on bleeding as primary outcome, and surgeon's satisfaction and hemodynamic stability as secondary outcomes in patients undergoing trans-sphenoidal resection of pituitary adenoma. Total numbers of 60 patients between 18-65 years old and candidate for elective trans-sphenoidal resection of pituitary adenoma were randomLy allocated to two groups; Dexmedetomidine infusion (0.6µg/kg/hour) or normal saline infusion. Mean arterial pressure (MAP), heart rate (HR), dose of hypnotics and narcotics during surgery, bleeding, and surgeon's satisfaction were recorded. Propofol maintenance dose (µg/kg/min) and total Fentanyl use (µg) were significantly lower in Dex group compare to control group (P=0.01 and 0.003, respectively). Total bleeding amount during operation in Dex group was significantly lower than control group (P=0.012). Surgeon's satisfaction was significantly higher in Dex group at the end of surgery. MAP and heart rate throughout surgery were significantly lower in Dex group compare to control group (P=0.001). Dexmedetomidine infusion (0.6µg/kg/hour) could reduce bleeding and provide surgeon's satisfaction during trans-sphenoidal resection of pituitary adenoma.

Improving the Stability and Accuracy of Power Hardware-in-the-Loop Simulation Using Virtual Impedance Method

Directory of Open Access Journals (Sweden)

Xiaoming Zha

2016-11-01

Full Text Available Power hardware-in-the-loop (PHIL systems are advanced, real-time platforms for combined software and hardware testing. Two paramount issues in PHIL simulations are the closed-loop stability and simulation accuracy. This paper presents a virtual impedance (VI method for PHIL simulations that improves the simulation’s stability and accuracy. Through the establishment of an impedance model for a PHIL simulation circuit, which is composed of a voltage-source converter and a simple network, the stability and accuracy of the PHIL system are analyzed. Then, the proposed VI method is implemented in a digital real-time simulator and used to correct the combined impedance in the impedance model, achieving higher stability and accuracy of the results. The validity of the VI method is verified through the PHIL simulation of two typical PHIL examples.

Coevolution within a transcriptional network by compensatory trans and cis mutations

KAUST Repository

Kuo, D.

2010-10-26

Transcriptional networks have been shown to evolve very rapidly, prompting questions as to how such changes arise and are tolerated. Recent comparisons of transcriptional networks across species have implicated variations in the cis-acting DNA sequences near genes as the main cause of divergence. What is less clear is how these changes interact with trans-acting changes occurring elsewhere in the genetic circuit. Here, we report the discovery of a system of compensatory trans and cis mutations in the yeast AP-1 transcriptional network that allows for conserved transcriptional regulation despite continued genetic change. We pinpoint a single species, the fungal pathogen Candida glabrata, in which a trans mutation has occurred very recently in a single AP-1 family member, distinguishing it from its Saccharomyces ortholog. Comparison of chromatin immunoprecipitation profiles between Candida and Saccharomyces shows that, despite their different DNA-binding domains, the AP-1 orthologs regulate a conserved block of genes. This conservation is enabled by concomitant changes in the cis-regulatory motifs upstream of each gene. Thus, both trans and cis mutations have perturbed the yeast AP-1 regulatory system in such a way as to compensate for one another. This demonstrates an example of “coevolution” between a DNA-binding transcription factor and its cis-regulatory site, reminiscent of the coevolution of protein binding partners.

Structural and mechanistic analysis of trans-3-chloroacrylic acid dehalogenase activity

Energy Technology Data Exchange (ETDEWEB)

Pegan, Scott D., E-mail: pegan@uic.edu [Center of Pharmaceutical Biotechnology and the Department of Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago (United States); Serrano, Hector; Whitman, Christian P. [Division of Medicinal Chemistry, College of Pharmacy, The University of Texas, Austin (United States); Mesecar, Andrew D., E-mail: pegan@uic.edu [Center of Pharmaceutical Biotechnology and the Department of Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago (United States)

2008-12-01

The X-ray structure of a noncovalently modified trans-3-chloroacrylic acid dehalogenase with a substrate-homolog acetate bound in the active site has been determined to 1.7 Å resolution. Elucidation of catalytically important water is reported and multiple conformations of the catalytic residue αGlu52 are observed. Trans-3-chloroacrylic acid dehalogenase (CaaD) is a critical enzyme in the trans-1, 3-dichloropropene (DCP) degradation pathway in Pseudomonas pavonaceae 170. This enzyme allows bacteria to use trans-DCP, a common component in commercially produced fumigants, as a carbon source. CaaD specifically catalyzes the fourth step of the pathway by cofactor-independent dehalogenation of a vinyl carbon–halogen bond. Previous studies have reported an X-ray structure of CaaD under acidic conditions with a covalent modification of the catalytic βPro1 residue. Here, the 1.7 Å resolution X-ray structure of CaaD under neutral (pH 6.5) conditions is reported without the presence of the covalent adduct. In this new structure, a substrate-like acetate molecule is bound within the active site in a position analogous to the putative substrate-binding site. Additionally, a catalytically important water molecule was identified, consistent with previously proposed reaction schemes. Finally, flexibility of the catalytically relevant side chain αGlu52 is observed in the structure, supporting its role in the catalytic mechanism.

[Trans fatty acids in the nutrition of children with neurological disorders].

Science.gov (United States)

Cortés, E; Aguilar, M J; Rizo, M M; Hidalgo, M J

2013-01-01

Trans-fatty acids are present in various foods, being the only source of the same in humans. Its presence in high concentrations is a risk factor for health, being involved in a series of events, cardiovascular, inflammatory, etc. Therefore, steps have been taken for its decrease in the diet. The aim is to determine serum and phospholipids of membranes in healthy children and neurological alterations. It has analyzed the fatty acids trans in 34 healthy children and 374 with various neurological pathologies. Serum and blood cells, making the lipid extraction, samples have been separation of the phospholipids of cells membranes, methylation of fatty acids, separation by gas chromatography and quantification using mass detector. The data have been processed statistically. The distribution of trans fatty acids and their sum is not normally distributed, so its nonparemetric tests were used. The values are higher than in serum phospholipids and membrane with a weak but significant correlation. The tC18: 1 is in a double proportion in children with neurological disorders in healthy children, both in serum and membrane phospholipids, with significant differences. The highest proportion of trans-fatty acids in the group of children with neurological disorders is caused no doubt by an increase in intake, due to less adequate food. Copyright © AULA MEDICA EDICIONES 2013. Published by AULA MEDICA. All rights reserved.

LA POLITIZACIÓN DEL CUERPO: SUBJETIVIDADES TRANS EN RESISTENCIA

Directory of Open Access Journals (Sweden)

Manuel Roberto Escobar C

2013-01-01

Full Text Available Se indaga por la experiencia del cuerpo trans (transgénero o transexual, cuya “artificialidad” interpela los órdenes del sujeto en la modernidad. El estudio se ubica en el contexto de dos ciudades latinoamericanas: México D. F. y Bogotá. Se plantea un vínculo entre la corporalidad trans, la biografía y los nombramientos de unas subjetividades que devienen tensión al orden somático moderno, tanto en sus versiones de docilidad y disciplinamiento, como también de hiperestesia y consumo. Así, la intervención singular sobre un cuerpo se torna en politización macro en el ámbito de lo público.

A modern trans-ionospheric propagation sensing system

Science.gov (United States)

Bishop, G. J.; Klobuchar, J. A.; Ronn, A. E.; Bedard, M. G.

1989-09-01

One of the most important potential problems with modern military systems which utilize spacecraft is the effect of the ionosphere on the radio signals which pass to and from the spacecraft. Such systems include active communications and navigation satellites as well as both ground-based and potential space-based ranging systems. The major effects the ionosphere can have on such systems are the additional time delay the electrons in the earth's ionosphere add to the free space path delay, the short term rate of change of this additional delay, amplitude scintillation or fading effects the signal encounters due to irregularities in the ionosphere, and Faraday rotation of linearly polarized radio waves transmitted through the ionosphere. While some of these effects were studied adequate models of these effects on military systems still do not exist. A modern trans-ionospheric sensing system, called TISS, is being procured which will consist of a number of stations located throughout the world, making real time measurements of the time delay of the ionosphere, and its rate of change, as well as amplitude scintillation, along several different viewing directions from each station. These trans-ionospheric measurements will be used to allow models, which currently provide only monthly propagation parameters. The real-time specifications of these parameters can then be used as decision aids in both the tactical and the strategic military environments. The TISS will include first order artificial intelligence design to aid in gathering the most appropriate sets of available real-time trans-ionospheric propagation data, and will communicate these data sets to the Air Weather Service Forecasting Center where they will be tailored to specific military customers.

Surgical outcomes of patients with superficial esophageal cancer. A comparison between trans-thoracic esophagectomy and trans-hiatal esophagectomy

International Nuclear Information System (INIS)

Matsumoto, Hideo; Kubota, Hisako; Murakami, Haruaki

2010-01-01

We inspected the feasibility of minimally invasive surgery for superficial esophageal cancer, the trans-hiatal approach without thoracotomy. We examined the surgical outcomes of 33 superficial esophageal cancer whose cancer had invaded the submucosal layer and who underwent resection in our hospital between April 2003 and April 2009. The patients who had tumor invasion of within the sm1 and no metastasis to the upper and middle mediastinum lymph nodes were operated on by the trans-hiatal esophagectomy (THE). The other patients were underwent ordinary trans-thoracic esophagectomy (TTE). After the operations, we recommended adjuvant chemoradiation therapy for all patients whose tumor were histopathologically proved to involve the sm2 layer as well as the vessels and/or lymphatic duct. Of our 33 cases, nine were diagnosed as pM1 or pM2. Two were diagnosed as pM3, one of which had lymph node metastasis. Eleven cases were diagnosed as pSM1, four as pSM2, and seven as pSM3; and lymph node metastasis was observed in 4 pSM1 cases (36%), 2 pSM2 cases (50%) and 5 pSM3 cases (71.4%). The five-year survival rate in all cases was 89.6%. The five-year survival rate by operating method was 100% in THE cases or 80.9% in TTE cases. The rates by tumor depth of invasion was 100% in pM1-2 cases, 92.3% in pM3-SM1 cases and 78.8% in pSM2-3 cases. It is concluded that the surgical outcome of THE in accordance with our indication criteria is equal to that of TTE for superficial esophageal cancer. (author)

Modelo de Adaptação de Roy: revisão integrativa dos estudos realizados à luz da teoria

Directory of Open Access Journals (Sweden)

Lays Pinheiro de Medeiros

2015-01-01

Full Text Available identificar las evidencias científicas acerca de los componentes del Modelo de Adaptación de Roy en poblaciones estudiadas a la luz de esta teoría. Método: revisión integradora de la literatura en las bases de datos Literatura Latinoamericana y Ciencias de la Salud del Caribe, Medical Literature Analysis and Retrieval System Online, Índice Bibliográfico Español de Ciencias de la Salud, Base de Datos de Enfermería, PubMed Central, Cumulative Index to Nursing and Allied Health Literature, Web Of Science eSciVerse Scopus. La muestra constó de 20 artículos publicados entre años 2005-2013. Resultados: se identificaron tres tipos de estímulos, 38 de los 82 problemas de adaptación, los cuatro modos de adaptación y los seis pasos del proceso de enfermería. Conclusión: hay necesidad de estudios sobre esta teoría que aborden todo el proceso de enfermería, culminándose en aumento de conocimientos específicos de enfermería y afirmación de esta ciencia en salud.

THE IMPACT OF CONSTRUCTION AND GENTRIFICATION ON AN OUTDOOR TRANS SEX WORK ENVIRONMENT: VIOLENCE, DISPLACEMENT AND POLICING.

Science.gov (United States)

Lyons, Tara; Krüsi, Andrea; Pierre, Leslie; Small, Will; Shannon, Kate

2017-12-01

The objective of this study was to investigate how environmental and structural changes to a trans outdoor work environment impacted sex workers in Vancouver, Canada. The issue of changes to the work area arose during qualitative interviews with 33 trans sex workers. In response, ethnographic walks that incorporated photography were undertaken with trans sex workers. Changes to the work environment were found to increase vulnerabilities to client violence, displace trans sex workers, and affect policing practices. Within a criminalized context, construction and gentrification enhanced vulnerabilities to violence and harassment from police and residents.

Trans-Saharan geopolitics. The game and the stakes

International Nuclear Information System (INIS)

Chegrouche, L.

2010-01-01

The geopolitics of energy exports from the trans-Saharan region are similar to the Caspian great game' at the end of the last century. In North/West Africa as in West/Central Asia, the question of control over hydrocarbon reserves and lines of access to those reserves lies at the source of various conflicts. Rivalries are expressed through open and complex conflicts in which powers confront one another over oil-rich zones through proxy ethnic, religious or cultural groups, as dictated by the colossal economic interests at stake. The increasing number of conflicts - the Niger Delta, Darfur, the Azawak, etc. - is an illustration of this. The shock waves from this rivalry undermine regional peace and security, as well as the security of international energy supplies. The question here is to understand the game and the stakes of this trans-Saharan chess-board, to study its principal features and its energetic consequences. The national oil companies and states of the region can work around or through the geopolitical rifts caused by local rivalries and extra-regional appetites. There is therefore a need to understand the ways in which the players in the trans-Saharan 'great game' interact with one another, an to identifies the effects these interactions may have in the field of energy, in terms of potential reserves and transport projects. The TSGP is presented as an illustration of this geopolitical dynamics. (author)

The Portuguese Cinema, Trans-temporality and the Myth

Directory of Open Access Journals (Sweden)

Sara Castelo Branco

2016-02-01

Full Text Available Eduardo Lourenço has focused some of his research on the historical-mythical relationship of the Portuguese with their country, claiming that they have been living in a kind of hyper-identity, incorporating an obsession with the past, which co-exists with a waiting utopian by future, as is demonstrates the Sebastianism myth. Focused on the representations of trans-temporality, identity, collective memory and myth, The Portuguese Cinema, Trans-temporality and the Myth, concentrated especially in Eduardo Lourenço's work to propose a research on how the identity myths – created and disseminated by Portuguese literature over the centuries – earned imagistic representations in the twentieth and twenty-first century’s, through a cinema that built or deconstructed these historical and patriotic mythological, inscribing image capacities to continually rebuild one mythologized common heritage.

FROM ADVANCE TO TRANS-PROFESSIONAL EDUCATION

Directory of Open Access Journals (Sweden)

A. G. Kislov

2018-01-01

Full Text Available Introduction. For several decades, the gap of vocational education with quickly changing realities in labour market, in the field of technologies and socio-economic sphere, and the need for the advancing vocational training, have been considered as the topical and steadily growing problems. Numerous attempts to overcome the presented above problems by means of fundamentalization and predictive methods have not led to anything so far. It is obvious that other education opportunities for in-demand, highly skilled, competitive specialists are needed.The aims of the publication are to discuss the potential of trans-professional education; to come up with arguments in favour of its introduction as the most perspective direction which might allow university and college graduates: to be guided better on labour market; to be more confident in unstable, unpredictable reality; to adapt quickly to dynamically changing situations in the world of professions.Methodology and research methods. The research paper is based on comparative analysis that provided an opportunity to find out the conceptual grounds of traditional mono-professional education and trans-professional education appropriate for challenges of modern Russia.Results and scientific novelty. It is emphasized that mono-professionalism as a paradigm reference point of professional education content is called for global reconsideration; for many years, preservation of traditional forms and methods have prevented mono-professionalism of good intentions to give it the advancing character, especially, at its initial stage.For the first time, trans-professional education has been considered as a result of considerably heterogeneous (as opposed to homogeneous bi- and polyprofessional training; the essence of that training consists in learning not related specialties concerned to one professional group, but professions that are absolutely far apart. Such approach will promote not only expansion of

A trans-disciplinary review of deep learning research for water resources scientists

OpenAIRE

Shen, Chaopeng

2017-01-01

Deep learning (DL), a new-generation artificial neural network research, has made profound strides in recent years. This review paper is intended to provide water resources scientists with a simple technical overview, trans-disciplinary progress update, and potentially inspirations about DL. Effective architectures, more accessible data, advances in regularization, and new computing power enabled the success of DL. A trans-disciplinary review reveals that DL is rapidly transforming myriad sci...

Problemas adaptativos segundo Roy e diagnósticos fundamentados na CIPE® em hipertensos com doenças associadas

Directory of Open Access Journals (Sweden)

Denizielle de Jesus Moreira Moura

2013-06-01

Full Text Available O objetivo do presente estudo foi identificar os problemas adaptativos e estímulos fundamentados no modelo teórico de Roy, bem como os diagnósticos de enfermagem segundo a CIPE® Versão 1. Estudo de casos múltiplos, realizado com 45 hipertensos com doenças associadas assistidos em uma unidade de saúde da Secretaria Executiva Regional V - Fortaleza. Dentre os problemas adaptativos identificados o sedentarismo é o mais presente (84,4% dos indivíduos, seguido de sobrepeso/obesidade (57,8% e distúrbios no padrão de sono (42,2%. 64,3% dos diagnósticos de enfermagem identificados encontram-se no âmbito biológico, sendo os de maior prevalência: Autocuidado Parcial (93,3%, Padrão de Exercício Diminuído (84,4%, Dentição Comprometida (82,2%, Aprendizagem Baixa (60,0%, Sobrepeso/Obesidade (57,7%. Concluiu-se que a identificação de problemas adaptativos auxiliam-nos na elaboração de diagnósticos, os quais, por sua vez, conferem uma linguagem própria à enfermagem além de maior autonomia profissional e qualidade na assistência.

Blood omega-3 and trans fatty acids in middle-aged acute coronary syndrome patients.

Science.gov (United States)

Harris, William S; Reid, Kimberly J; Sands, Scott A; Spertus, John A

2007-01-15

We tested the hypothesis that lower blood omega-3 (omega-3) fatty acids (FAs) and/or higher trans FAs are associated with the risk of an acute coronary syndrome (ACS). Higher levels of omega-3 FA have been associated with decreased risk of sudden cardiac death. However, their association with ACS risk is unclear. Although higher self-reported intakes of trans FAs have been linked to increased coronary risk, the association between blood levels of trans FA and ACS risk is also unknown. We analyzed the FA composition of whole blood from 94 subjects with ACS and 94 age-, gender-, and race-matched controls. Omega-3 and trans FA associations with ACS were assessed using multivariable models after adjusting for smoking status, alcohol use, diabetes, body mass index, serum lipids, and history of myocardial infarction or revascularization. Subjects' mean age was 47 years, 54% were men, and 80% were Caucasian. Whole blood long-chain omega-3 FA (eicosapentaenoic acid [EPA] plus docosahexaenoic acid [DHA]) content was 29% lower in patients than in controls (1.7 +/- 0.9% vs 2.4 +/- 1.4%, p ACS, but higher blood trans FA content is not. Blood EPA + DHA may serve as a new, modifiable risk factor for ACS.

Trans-Disciplinary Education for Sustainable Marine and Coastal Management: A Case Study in Taiwan

Directory of Open Access Journals (Sweden)

Hsiao-Chien Lee

2016-10-01

Full Text Available The present study aims to investigate the effect of a trans-disciplinary design of curricula, deemed a powerful tool for teaching and research on complex environmental problems, with a goal to help solve the real problems that climate change has brought to the coastal environment in Taiwan. Three major real-life problems in southern Taiwan—declining mullet fisheries, flooding, and coral bleaching—were integrated into four courses. Adopting a qualitative case study method, the researchers investigated the student perceptions of the trans-disciplinary learning experiences, their attitudes toward marine and coastal environmental protection, and their capability of solving the problems related to marine and coastal environments. The researchers employed various methods to analyze the student reflection reports, student self-evaluation forms, and the tape-recorded class meetings. The findings suggest the following: the trans-disciplinary curriculum stands to be an innovative yet indispensable design for coastal management education; such a curriculum benefits students by equipping them with essential knowledge and skills to succeed in future marine conservation; action learning for marine and coastal sustainability serves as the final goal of trans-disciplinary learning project; a trans-disciplinary case study on the design of curricula provides effective knowledge integration of marine and coastal sustainability.

Synthesis and bacterial metabolism of cis- and trans-2-alkyl analogues of sodium cyclamate.

Science.gov (United States)

Wiley, R A; Pearson, D A; Schmidt, V; Wesche, S B; Roxon, J J

1983-07-01

Sodium cyclamate is an effective artificial sweetner, which has been banned from the U.SD. market because of alleged carcinogenic properties. It appears that cyclohexylamine, liberated from cyclamate as a result of bacterial mtabolism, is the proximate carcinogen. In an effort to elucidate the extent to which analogues of cyclamate would enter into the bacterial metabolic pathway, as well as any stereochemical requirements which might exist, several 2-alkaly analogues of sodium cyclamate were prepared. It was found that trans-N-(2-methylcyclohexyl)sulfamate (trans-2a) and trans-N-(2-ethylcyclohexyl)sulfamate were hydrolyzed by freshly collected fecal suspensions from rats fed cyclamate, but not from control rats, at the same rate as cyclamate itself. trans-N-(2-Isopropylcyclohexyl)sulfamate (trans-2c) was not hydrolyzed at all. Surprisingly, two of the analogous cis compounds (cis-2a and cis-2c, respectively) were hydrolyzed by fecal suspensions from control, as well as from cyclamate-fed, rats. Moreover, cis-2a was hydrolyzed by incubating it in medium only. Thus, it is apparent that stereochemical influences on the chemical properties of these compounds are substantial. These results do not appear to point the way toward a safe, nonmetabolizable sweetening agent.

"It's a Hard Line to Walk": Black Non-Binary Trans* Collegians' Perspectives on Passing, Realness, and Trans*-Normativity

Science.gov (United States)

Nicolazzo, Z.

2016-01-01

Being labeled as "abnormal, or deviant, or not being one of the rest of us" has real effects for one's life chances. Trans* people are one such group who have continually been codified as abnormal, abject, weird, deceptive, and social pariahs. The purpose of the following study was to explore how the concepts of passing, realness, and…

Synthesis, resolution and radioiodination of S(-)trans-5-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)amino]tet ralin-S(-)trans-5-OH-PIPAT: a new dopamine D2-like receptor ligand

International Nuclear Information System (INIS)

Chumpradit, Sumalee; Meiping Kung; Vessotskie, Janet; Kung, H.F.

1995-01-01

A new dopamine D2-like receptor ligand, (R,S)trans-5-hydroxy-2-[N-n0propyl-N-(3'-iodo-2'-propeny)amino]tet ralin ((R,S)trans-5-OH-PIPAT,3), based on high affinity dopamine receptor agonist 5-hydroxy-2-[N,N-(di-n-propyl)-2-amino]tetralin (5-OH-DPAT,1), was prepared. The synthesis was achieved by a reductive amination of 5-methoxy-2-tetralone with n-propylamine, followed by N-alkylation, to afford 5-methoxy-N-propyl-N-2'-aminotetralin,7. Reduction of 7 with tributyltin hydride gave the tri-n-butyl tin derivative,8, which was converted to 9 by an iododemetalation reaction. Demethylation of 9 gave the desired compound, (R,S)trans-5-OH-PIPAT,3. The resolved (R) and (S)trans-5-OH-PIPAT,3 were also quantitatively prepared. (author)

Trans-Selective Rhodium Catalysed Conjugate Addition of Organoboron Reagents to Dihydropyranones

Directory of Open Access Journals (Sweden)

Hannah J. Edwards

2015-04-01

Full Text Available The selective synthesis of 2,6-trans-tetrahydropyran derivatives employing the rhodium catalysed addition of organoboron reagents to dihydropyranone templates, derived from a zinc-catalysed hetero-Diels-Alder reaction, is reported. The addition of both arylboronic acids and potassium alkenyltrifluoroborates have been accomplished in high yields using commercially-available [Rh(cod(OH]2 catalyst. The selective formation of the 2,6-trans-tetrahydropyran stereoisomer is consistent with a mechanism involving alkene association and carbometalation on the less hindered face of the dihydropyranone.

Protein trans-splicing of multiple atypical split inteins engineered from natural inteins.

Directory of Open Access Journals (Sweden)

Ying Lin

Full Text Available Protein trans-splicing by split inteins has many uses in protein production and research. Splicing proteins with synthetic peptides, which employs atypical split inteins, is particularly useful for site-specific protein modifications and labeling, because the synthetic peptide can be made to contain a variety of unnatural amino acids and chemical modifications. For this purpose, atypical split inteins need to be engineered to have a small N-intein or C-intein fragment that can be more easily included in a synthetic peptide that also contains a small extein to be trans-spliced onto target proteins. Here we have successfully engineered multiple atypical split inteins capable of protein trans-splicing, by modifying and testing more than a dozen natural inteins. These included both S1 split inteins having a very small (11-12 aa N-intein fragment and S11 split inteins having a very small (6 aa C-intein fragment. Four of the new S1 and S11 split inteins showed high efficiencies (85-100% of protein trans-splicing both in E. coli cells and in vitro. Under in vitro conditions, they exhibited reaction rate constants ranging from ~1.7 × 10(-4 s(-1 to ~3.8 × 10(-4 s(-1, which are comparable to or higher than those of previously reported atypical split inteins. These findings should facilitate a more general use of trans-splicing between proteins and synthetic peptides, by expanding the availability of different atypical split inteins. They also have implications on understanding the structure-function relationship of atypical split inteins, particularly in terms of intein fragment complementation.

PENYUSUNAN SKENARIO KEBIJAKAN UNTUK PENGEMBANGAN BRT TRANS SEMARANG DENGAN PENDEKATAN SISTEM DINAMIK

Directory of Open Access Journals (Sweden)

Aries Susanty

2014-10-01

Full Text Available [Preparation for Policy Scenarios for Developing the Bus Rapid Transit (BRT Trans Semarang with Dynamic System Approach] Related to the complexity of the problem faced by Bus Rapid Transit (BRT Trans Semarang, this research attempts to develop a framework for dynamic development of BRT Trans Semarang and provide a platform to support policy making related to performance improvement of BRT Trans Semarang. This research use system dynamics (SD methodology. There are three scenarios constructed in this research and then a system dynamics model built based on them for the next five years. The first scenario is providing some feeder that will take the passenger on the bus, the second scenario is providing some new bus, and the third scenario is a combination of providing a number of feeders and also some new bus. There are three criteria which are used to evaluate the result of each scenario, i. e the achievement of the target of load factor (greater than 70%, the amount of total subsidy for operational of BRT, and percentage of the number of people that change their moda of transportation, from using private vehicles to BRT. The result of simulation with system dynamic indicated that scenario 1 is better than the existing condition; scenario 1 also better than scenario 2 or scenario 3. By providing some feeder, operational BRT can achieve the target of load factor at month 15, the government also does not need to issue subsidies for operational of BRT Trans Semarang, as well as the percentage of the number of people who moved from using private vehicles reached 26%.

Consumo de ácidos grasos trans y riesgo cardiovascular Consumption of trans fatty acids and cardiovascular risk

Directory of Open Access Journals (Sweden)

Fernando Manzur J

2009-06-01

Full Text Available Los ácidos grasos con configuración trans poco se encuentran en los alimentos de manera natural, sino que se incorporan a éstos como consecuencia de modificaciones principalmente debidas a los procesos industriales de hidrogenación a que se someten los aceites para convertirlos en grasas sólidas. Aún cuando su estructura incluye dobles enlaces, el tipo de configuración permite un comportamiento biológico similar al de los ácidos grasos saturados, con efectos negativos sobre múltiples funciones celulares. La evidencia demuestra que son perjudiciales para la salud, en especial a lo que se refiere a riesgo de enfermedad cardiovascular, razón por la cual es importante disminuir su consumo. Teniendo en consideración la evidencia obtenida de investigaciones sobre las alteraciones del metabolismo producidas por los ácidos grasos trans, es posible plantear una precaución lógica hacia el consumo de dietas ricas en dichos ácidos. Sus efectos deletéreos serían incluso peores en aquellas poblaciones que consumen bajas cantidades de ácidos grasos esenciales. De ahí surge la importancia de iniciar con prontitud políticas sanitarias orientadas a controlar la aterosclerosis en nuestro país. Las mismas deben estar necesariamente sustentadas sobre un conocimiento profundo de las características o condiciones particulares a las que nuestra población se encuentra sometida. Sólo así podrá darse inicio a una intervención efectiva sobre nuestros cuestionados hábitos alimentarios.Trans fatty acids are scarcely found naturally in food; they are incorporated to it as a result of modifications mainly due to hydrogenation industrial processes to which oils are submitted in order to obtain solid fats. Even when its structure includes double bonds, the type of configuration allows a biological behavior similar to that of saturated fatty acids, with negative effects on multiple cellular functions. The evidence shows that they are harmful to health

Trans-apical aortic valve implantation in a patient with stentless valve degeneration.

Science.gov (United States)

Kapetanakis, Emmanouil I; MacCarthy, Philip; Monaghan, Mark; Wendler, Olaf

2011-06-01

Trans-apical valve-in-valve trans-catheter aortic valve implantation (TAVI) has successfully been performed in selected, high-risk patients, who suffered prosthetic degeneration after aortic valve replacement using stented xenografts. We report the case of a 79-year-old male patient who underwent one of the first successful TAVIs in a failing stentless bioprosthesis. Copyright © 2010 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.

Health, disability and quality of life among trans people in Sweden-a web-based survey.

Science.gov (United States)

Zeluf, Galit; Dhejne, Cecilia; Orre, Carolina; Nilunger Mannheimer, Louise; Deogan, Charlotte; Höijer, Jonas; Ekéus Thorson, Anna

2016-08-30

Swedish research concerning the general health of trans people is scarce. Despite the diversity of the group, most Swedish research has focused on gender dysphoric people seeking medical help for their gender incongruence, or on outcomes after medical gender-confirming interventions. This paper examines self-rated health, self-reported disability and quality of life among a diverse group of trans people including trans feminine, trans masculine, and gender nonbinary people (identifying with a gender in between male of female, or identify with neither of these genders) as well as people self-identifying as transvestites. Participants were self-selected anonymously to a web-based survey conducted in 2014. Univariable and multivariable regression analyses were performed. Three backward selection regression models were conducted in order to identify significant variables for the outcomes self-rated health, self-reported disability and quality of life. Study participants included 796 individuals, between 15 and 94 years of age who live in Sweden. Respondents represented a heterogeneous group with regards to trans experience, with the majority being gender nonbinary (44 %), followed by trans masculine (24 %), trans feminine (19 %) and transvestites (14 %). A fifth of the respondents reported poor self-rated health, 53 % reported a disability and 44 % reported quality of life scores below the median cut-off value of 6 (out of 10). Nonbinary gender identity (adjusted Odds Ratio (aOR) = 2.19; 95 % CI: 1.24, 3.84), negative health care experiences (aOR = 1.92; 95 % CI: 1.26, 2.91) and not accessing legal gender recognition (aOR = 3.06; 95 % CI: 1.64, 5.72) were significant predictors for self-rated health. Being gender nonbinary (aOR = 2.18; 95 % CI: 1.35, 3.54) and history of negative health care experiences (aOR = 2.33; 95 % CI: 1.54, 3.52) were, in addition, associated with self-reported disability. Lastly, not accessing legal gender

Health, disability and quality of life among trans people in Sweden–a web-based survey

Directory of Open Access Journals (Sweden)

Galit Zeluf

2016-08-01

Full Text Available Abstract Background Swedish research concerning the general health of trans people is scarce. Despite the diversity of the group, most Swedish research has focused on gender dysphoric people seeking medical help for their gender incongruence, or on outcomes after medical gender-confirming interventions. This paper examines self-rated health, self-reported disability and quality of life among a diverse group of trans people including trans feminine, trans masculine, and gender nonbinary people (identifying with a gender in between male of female, or identify with neither of these genders as well as people self-identifying as transvestites. Methods Participants were self-selected anonymously to a web-based survey conducted in 2014. Univariable and multivariable regression analyses were performed. Three backward selection regression models were conducted in order to identify significant variables for the outcomes self-rated health, self-reported disability and quality of life. Results Study participants included 796 individuals, between 15 and 94 years of age who live in Sweden. Respondents represented a heterogeneous group with regards to trans experience, with the majority being gender nonbinary (44 %, followed by trans masculine (24 %, trans feminine (19 % and transvestites (14 %. A fifth of the respondents reported poor self-rated health, 53 % reported a disability and 44 % reported quality of life scores below the median cut-off value of 6 (out of 10. Nonbinary gender identity (adjusted Odds Ratio (aOR = 2.19; 95 % CI: 1.24, 3.84, negative health care experiences (aOR = 1.92; 95 % CI: 1.26, 2.91 and not accessing legal gender recognition (aOR = 3.06; 95 % CI: 1.64, 5.72 were significant predictors for self-rated health. Being gender nonbinary (aOR = 2.18; 95 % CI: 1.35, 3.54 and history of negative health care experiences (aOR = 2.33; 95 % CI: 1.54, 3.52 were, in addition, associated with self

Modelling post-depositional transport of PAHs in aquatic bed sediments using CoReTranS

Energy Technology Data Exchange (ETDEWEB)

Go, Jason [Imperial College London, London (United Kingdom). Dept. of Earth Science and Engineering; Stegemann, Julia A. [Imperial College London, London (United Kingdom). Dept. of Civil, Environmental and Geomatic Engineering

2012-12-15

Purpose: Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous and persistent contaminants in aquatic bed sediments. A better understanding of their in-bed fate and transport is therefore key in minimising the risk to the environment over time through various remediation and monitoring strategies. Since ecological effects and risks are related to contaminant concentrations, this study developed CoReTranS, a predictive model that simulates one-dimensional organic contaminant reaction and transport in bed sediments. Materials and methods: CoReTranS was benchmarked against analytical solutions of simplified reactive transport models and validated using a published study of marsh sediments contaminated with petroleum-derived hydrocarbons from Wild Harbour, West Falmouth, MA, USA. Results and discussion: The CoReTranS model effectively predicted the vertical distribution of PAHs in the Wild Harbour sediments as confirmed by the modelling results from the published study. The CoReTranS model was also used to interpret results from a published study of PAH-contaminated fjord sediments from Kitimat Arm in British Columbia, Canada. Specific insights into the post-depositional fate and transport of selected PAHs in the Kitimat fjord sediments were obtained by comparing the measured concentration-depth profiles with the numerical results from the CoReTranS model. Key parameters such as effective diffusivity of contaminants and burial velocities of sediment particles were shown to possibly account for the predicted concentrations-depth profiles in the Kitimat fjord sediments. Conclusions: As demonstrated, CoReTranS can simulate reactive transport models in order to predict PAH concentration profiles in porewater under site-specific conditions. The information derived from the use of the CoReTranS model highlighted practical application of such information by engineers to site-specific risk assessment and remediation. (orig.)

Photocytotoxic trans-diam(m)ine platinum(IV) diazido complexes more potent than their cis isomers.

Science.gov (United States)

Farrer, Nicola J; Woods, Julie A; Munk, Vivienne P; Mackay, Fiona S; Sadler, Peter J

2010-02-15

The photocytotoxicity of a series of anticancer trans-dihydroxido [Pt(N(3))(2)(OH)(2)(NH(3))(X)] (X = alkyl or aryl amine) platinum(IV) diazido complexes has been examined, and the influence of cis-trans isomerism has been investigated. A series of photoactivatable Pt(IV)-azido complexes has been synthesized: The synthesis, characterization, and photocytotoxicity of six mixed-ligand ammine/amine Pt(IV) diazido complexes, cis,trans,cis-[Pt(N(3))(2)(OH)(2)(NH(3))(X)] where X = propylamine (4c), butylamine (5c), or pentylamine (6c) and aromatic complexes where X = pyridine (7c), 2-methylpyridine (8c), or 3-methylpyridine (9c) are reported. Six all-trans isomers have also been studied where X = methylamine (2t), ethylamine (3t), 2-methylpyridine (8t), 4-methylpyridine (10t), 3-methylpyridine (9t), and 2-bromo-3-methylpyridine (11t). All of the complexes exhibit intense azide-to-Pt(IV) LMCT bands (ca. 290 nm for trans and ca. 260 nm for cis). When irradiated with UVA light (365 nm), the Pt(IV) complexes undergo photoreduction to Pt(II) species, as monitored by UV-vis spectroscopy. The trans isomers of complexes containing aliphatic or aromatic amines were more photocytotoxic than their cis isomers. One of the cis complexes (9c) was nonphotocytotoxic despite undergoing photoreduction. Substitution of NH(3) ligands by MeNH(2) or EtNH(2) results in more potent photocytotoxicity for the all-trans complexes. The complexes were all nontoxic toward human keratinocytes (HaCaT) and A2780 human ovarian cancer cells in the dark, apart from the 3-methylpyridine (9t), 2-bromo-3-methylpyridine (11t), and 4-methylpyridine (10t) derivatives.

Modelo de adaptación de Roy en el baño en cama

Directory of Open Access Journals (Sweden)

José Manuel Flórez Ramos

2016-09-01

Full Text Available Objetivo: Evaluar los efectos de dos tipos de baño en cama: seco y tradicional, frente a la respuesta adaptativa en modo fisiológico de Roy en paciente crítico cardiovascular (pccv. Metodología: Estudio de diseño cuasi-experimental, de intervención con preprueba y posprueba, realizado en la Unidad de Cuidados Intensivos (uci de la Clínica Medellín. El grupo experimental fue de 36 pacientes, a quienes se les realizó baño en cama seco; el grupo control fue de 36 pacientes, a quienes se les realizó baño en cama tradicional. Se utilizaron los estadísticos Wilcoxon, u de Mann Whitney y el Modelo de dos factores, con medidas repetidas en un factor. Resultados: Se encontró un efecto benéfico durante la realización del baño en cama en seco, puesto que los indicadores de tensión arterial y frecuencia respiratoria no presentaron respuestas inefectivas (p = 0,03 y p = 0,013, respectivamente. Por otra parte, las variables duración del baño y cuidados adicionales fueron satisfactorias en comparación con el baño en cama tradicional. Conclusiones: Los resultados permiten recomendar el uso del baño en cama en seco en paciente crítico cardiovascular (pccv, en virtud de los efectos benéficos que facilitan los procesos de adaptación, contribuyendo así a cualificar el cuidado de enfermería en este tipo de pacientes.

Gender identification and sex reassignment surgery in the trans population: a survey study in France.

Science.gov (United States)

Giami, Alain; Beaubatie, Emmanuelle

2014-11-01

Drawing from controversies between medical, legal, and associative actors about the obligation of sex reassignment surgeries (SRS) for people who intend to change their civil status, this article discusses the role that medical procedures, and particularly SRS, play in contemporary gender identifications and transition pathways in France. In 2010, the French National Institute of Health and Medical Research conducted a national survey in order to study the sociodemographic characteristics, access to medical, and psychological care, and state of health among trans individuals. After a long period of ethnographic work during which a partnership was established with trans actors to map the social, medical, and political landscape of trans communities, a questionnaire was developed and distributed between July and October 2010 in collaboration with most of the trans organizations and public and private health professionals operating in France. Overall, 381 self-identified trans individuals returned the anonymous self-administered questionnaire. The results highlighted the heterogeneity of the trans population, whose definition cannot be reduced to a group of individuals undergoing standardized hormonal treatments and SRS. Two central indicators, sex assigned at birth and gender self-identification, enabled us to describe and analyze different medical and legal pathways with a particular focus on SRS, which is often compulsory for a change of civil status in France. Although SRS remains an important factor in an individual's subjective evaluation of the success of the transition pathway, its practice varies depending on one's sex assigned at birth and gender identification.

Trans?generational plasticity in response to immune challenge is constrained by heat stress

OpenAIRE

Roth, Olivia; Landis, Susanne H.

2017-01-01

Trans-generational plasticity is the adjustment of phenotypes to changing habitat conditions that persist longer than the individual lifetime. Fitness benefits (adaptive TGP) are expected upon matching parent-offspring environments. In a global change scenario, several performance-related environmental factors are changing simultaneously. This lowers the predictability of offspring environmental conditions, potentially hampering the benefits of trans-generational plasticity. For the first tim...

Participatory Disease Surveillance in the Detection of Trans ...

African Journals Online (AJOL)

This paper reports the detection of trans-boundary animal diseases using participatory disease surveillance in Borno State. Participatory epidemiology is an emerging field that is based on the use of participatory techniques for harvesting qualitative epidemiological intelligence contained within community observations, ...

Variability in the Content of Trans-Resveratrol, Trans-ε-Viniferin and R2-Viniferin in Grape Cane of Seven Vitis vinifera L. Varieties during a Three-Year Study.

Science.gov (United States)

Tříska, Jan; Vrchotová, Naděžda; Balík, Josef; Soural, Ivo; Sotolář, Radek

2017-06-03

Grape canes are a waste product from viticulture that show potential as an industrially extractable source of stilbenes, which are valuable for medical and other purposes. In this work, grape canes collected in three consecutive years (2014-2016) at six different places in South Moravia, Czech Republic were extracted, and the contents of trans -resveratrol, trans -ε-viniferin, and r2-viniferin were determined by high-performance liquid chromatography. The study included three blue grape varieties of Vitis vinifera L. (Cabernet Moravia, Blaufränkisch, and Piwi variety Laurot) and four white grape varieties (Chardonnay, Green Veltliner, Piwi variety Hibernal, and Piwi variety Malverina). From the viewpoint of producing extracts with high stilbenes content, the Hibernal variety is clearly the best. The mean amounts of the stilbenes for this variety at all localities and for all three years were 4.99 g/kg for trans -resveratrol, 3.24 g/kg for trans -ε-viniferin, and 1.73 g/kg for r2-viniferin. The influence of vintage, locality, and variety on the amounts of stilbenes was studied using PCA analysis. In contrast to expectations, there was no strong impact of locality on stilbenes content. The differences were varietal for most varieties, regardless of the area of cultivation. Laurot and Hibernal varieties did differ significantly in that respect, however, as they exhibited clear dependence on location.

Naturally occurring and process-induced trans fatty acids and ...

African Journals Online (AJOL)

CHOKRI

2013-05-22

May 22, 2013 ... Key words: Trans-fatty acids, conjugated linoleic acid, butter oil. INTRODUCTION ... important role in determining risk of coronary heart diseases (CHD) than ... performance liquid chromatography (HPLC) grade, supplied by.

Endoscopic trans-sphenoidal drainage of petrous apex cholesterol ...

African Journals Online (AJOL)

Cholesterol granulomas of the petrous apex are rare lesions that pose challenging surgical decisions and approaches when attempting surgical drainage. In this article we present 2 cases of successful surgical management using an endoscopic trans-sphenoidal approach and review the requirements and considerations ...

Cis- and trans-perfluorodecalin: Infrared spectra, radiative efficiency and global warming potential

Science.gov (United States)

Le Bris, Karine; DeZeeuw, Jasmine; Godin, Paul J.; Strong, Kimberly

2017-12-01

Perfluorodecalin (PFD) is a molecule used in various medical applications for its capacity to dissolve gases. This potent greenhouse gas was detected for the first time in the atmosphere in 2005. We present infrared absorption cross-section spectra of a pure vapour of cis- and trans-perfluorodecalin at a resolution of 0.1 cm-1. Measurements were performed in the 560-3000 cm-1 spectral range using Fourier transform spectroscopy. The spectra have been compared with previous experimental data and theoretical calculations by density functional theory. The new experimental absorption cross-sections have been used to calculate a lifetime-corrected radiative efficiency at 300 K of 0.62 W m-2 ppb-1 and 0.57 W.m-2.ppb-1 for the cis and trans isomers respectively. This leads to a 100-year time horizon global warming potential of 8030 for cis-PFD and 7440 for trans-PFD.

RegTransBase - A Database Of Regulatory Sequences and Interactionsin a Wide Range of Prokaryotic Genomes

Energy Technology Data Exchange (ETDEWEB)

Kazakov, Alexei E.; Cipriano, Michael J.; Novichkov, Pavel S.; Minovitsky, Simon; Vinogradov, Dmitry V.; Arkin, Adam; Mironov, AndreyA.; Gelfand, Mikhail S.; Dubchak, Inna

2006-07-01

RegTransBase, a manually curated database of regulatoryinteractions in prokaryotes, captures the knowledge in publishedscientific literature using a controlled vocabulary. Although a number ofdatabases describing interactions between regulatory proteins and theirbinding sites are currently being maintained, they focus mostly on themodel organisms Escherichia coli and Bacillus subtilis, or are entirelycomputationally derived. RegTransBase describes a large number ofregulatory interactions reported in many organisms and contains varioustypes of experimental data, in particular: the activation or repressionof transcription by an identified direct regulator; determining thetranscriptional regulatory function of a protein (or RNA) directlybinding to DNA (RNA); mapping or prediction of binding site for aregulatory protein; characterization of regulatory mutations. Currently,the RegTransBase content is derived from about 3000 relevant articlesdescribing over 7000 experiments in relation to 128 microbes. It containsdata on the regulation of about 7500 genes and evidence for 6500interactions with 650 regulators. RegTransBase also contains manuallycreated position weight matrices (PWM) that can be used to identifycandidate regulatory sites in over 60 species. RegTransBase is availableat http://regtransbase.lbl.gov.

Study on expansion power recovery in CO2 trans-critical cycle

International Nuclear Information System (INIS)

Tian Hua; Ma Yitai; Li Minxia; Wang Wei

2010-01-01

Due to the ozone depletion potential and global warming potential of CFCs and HCFCs, CO 2 is considered as most potential alternative refrigerant. However, there are serious throttle losses and low system efficiency to CO 2 trans-critical cycle because of its low critical temperature and high operating pressure. The aim of this paper is to design an expander to recover expansion power in CO 2 trans-critical cycle. The theoretical analysis and calculation show that 14-23% of input power of compressor can be recovered. A prototype of rolling piston expander is designed and manufactured and its test facility is established. The test facility consists of CO 2 trans-critical cycle, the expander, the chilling water system and the cooling water system. The experimental results show that the recovery ratio and expander efficiency are affected by rotational speed, inlet temperature and mass flow of expander. The highest recovery ratio can reach to 0.145, which means 14.5% of input power of compressor can be recovered. The expander efficiency can reach to 45%.

Experiences of stigma and discrimination in social and healthcare settings among trans people living with HIV in the UK.

Science.gov (United States)

Hibbert, M; Wolton, A; Crenna-Jennings, W; Benton, L; Kirwan, P; Lut, I; Okala, S; Ross, M; Furegato, M; Nambiar, K; Douglas, N; Roche, J; Jeffries, J; Reeves, I; Nelson, M; Weerawardhana, C; Jamal, Z; Hudson, A; Delpech, V

2018-07-01

The People Living with HIV StigmaSurvey UK 2015 was a community led national survey investigating experiences of people living with HIV in the UK in the past 12 months. Participants aged 18 and over were recruited through over 120 cross-sector community organisations and 46 HIV clinics to complete an anonymous online survey. Trans is an umbrella term which refers to individuals whose current gender identity is different to the gender they were assigned at birth. Trans participants self-identified via gender identity and gender at birth questions. Descriptive analyses of reported experiences in social and health care settings were conducted and multivariate logistic regression analyses were used to identify sociodemographic predictors of reporting being treated differently to non-HIV patients, and being delayed or refused healthcare treatment in the past 12 months. 31 out of 1576 participants (2%) identified as trans (19 trans women, 5 trans men, 2 gender queer/non-binary, 5 other). High levels of social stigma were reported for all participants, with trans participants significantly more likely to report worrying about verbal harassment (39% vs. 23%), and exclusion from family gatherings (23% vs. 9%) in the last 12 months, compared to cisgender participants. Furthermore, 10% of trans participants reported physical assault in the last 12 months, compared to 4% of cisgender participants. Identifying as trans was a predictor of reporting being treated differently to non-HIV patients (48% vs. 30%; aOR 2.61, CI 1.06, 6.42) and being delayed or refused healthcare (41% vs. 16%; aOR 4.58, CI 1.83, 11.44). Trans people living with HIV in the UK experience high levels of stigma and discrimination, including within healthcare settings, which is likely to impact upon health outcomes. Trans-specific education and awareness within healthcare settings could help to improve service provision for this demographic.

2006 marketplace survey of trans-fatty acid content of margarines and butters, cookies and snack cakes, and savory snacks.

Science.gov (United States)

Albers, Matthew J; Harnack, Lisa J; Steffen, Lyn M; Jacobs, David R

2008-02-01

In recent years, newer technologies have been developed to reduce the trans-fat content of fats and oils used in manufacturing food products. To examine the implications of these changes on foods in the marketplace, a survey was conducted to assess current levels of trans and saturated fat in three food categories: margarines and butters; cookies and snack cakes; and savory snacks. A sampling of products from each category was conducted at a Wal-Mart Supercenter in the Minneapolis-St Paul, MN, metropolitan area in July of 2006. All information was obtained from product labels, except price, which was recorded from price listings on product shelving. Most margarines and butters (21 of 29), cookies and snack cakes (34 of 44), and savory snacks (31 of 40) were labeled as containing 0 g trans fat. However, some products contained substantial amounts of trans fat. Most notably, 3 of 40 savory snack products were labeled as containing > or =3 g trans fat. Significant inverse correlations were found between product price and the saturated and trans-fat content of margarines (r=-0.45) and savory snacks (r=-0.32). In conclusion, it appears that the food industry has made progress in reducing the trans-fat content in a variety of products. Nonetheless, consumers need to read product labels because the trans-fat content of individual products can vary considerably. Products that are lower in trans and saturated fat tend to cost more, which may be a barrier to their purchase for price-conscious consumers.

UMTRA water sampling technical (peer) review: Responses to observations, comments, and recommendations submitted by Don Messinger (Roy F. Weston, Inc.)

International Nuclear Information System (INIS)

1993-08-01

An independent technical review (peer review) was conducted during the period of September 15--17, 1992. The review was conducted by C. Warren Ankerberg (Geraghty and Miller, Inc., Tampa, Florida) and Don Messinger (Roy F. Weston, Inc., West Chester, Pennsylvania). The review was held at Jacobs Engineering in Albuquerque, New Mexico, and at the Shiprock, New Mexico, site. The peer review included a review of written documentation [water sampling standard operating procedures (SOP)], an inspection of technical reports and other deliverables, a review of staff qualifications and training, and a field visit to evaluate the compliance of field procedures with SOPS. Upon completion of the peer review, each reviewer independently prepared a report of findings from the review. The reports listed findings and recommended actions. This document responds to the observations, comments, and recommendations submitted by Don Messinger following his review. The format of this document is to present the findings and recommendations verbatim from Mr. Messinger's report, followed by responses from the UMTRA Project staff. Included in the responses from the UMTRA Project staff are recommended changes in SOPs and strategies for implementing the charges

Overexpression of an isopentenyl diphosphate isomerase gene to enhance trans-polyisoprene production in Eucommia ulmoides Oliver

Directory of Open Access Journals (Sweden)

Chen Ren

2012-10-01

Full Text Available Abstract Background Natural rubber produced by plants, known as polyisoprene, is the most widely used isoprenoid polymer. Plant polyisoprenes can be classified into two types; cis-polyisoprene and trans-polyisoprene, depending on the type of polymerization of the isoprene unit. More than 2000 species of higher plants produce latex consisting of cis-polyisoprene. Hevea brasiliensis (rubber tree produces cis-polyisoprene, and is the key source of commercial rubber. In contrast, relatively few plant species produce trans-polyisoprene. Currently, trans-polyisoprene is mainly produced synthetically, and no plant species is used for its commercial production. Results To develop a plant-based system suitable for large-scale production of trans-polyisoprene, we selected a trans-polyisoprene-producing plant, Eucommia ulmoides Oliver, as the target for genetic transformation. A full-length cDNA (designated as EuIPI, Accession No. AB041629 encoding isopentenyl diphosphate isomerase (IPI was isolated from E. ulmoides. EuIPI consisted of 1028 bp with a 675-bp open reading frame encoding a protein with 224 amino acid residues. EuIPI shared high identity with other plant IPIs, and the recombinant protein expressed in Escherichia coli showed IPI enzymatic activity in vitro. EuIPI was introduced into E. ulmoides via Agrobacterium-mediated transformation. Transgenic lines of E. ulmoides overexpressing EuIPI showed increased EuIPI expression (up to 19-fold that of the wild-type and a 3- to 4-fold increase in the total content of trans-polyisoprenes, compared with the wild-type (non-transgenic root line control. Conclusions Increasing the expression level of EuIPI by overexpression increased accumulation of trans-polyisoprenes in transgenic E. ulmoides. IPI catalyzes the conversion of isopentenyl diphosphate to its highly electrophilic isomer, dimethylallyl diphosphate, which is the first step in the biosynthesis of all isoprenoids, including polyisoprene. Our

Risk Factors for Non-Suicidal Self-Injury Among Trans Youth.

Science.gov (United States)

Arcelus, Jon; Claes, Laurence; Witcomb, Gemma L; Marshall, Ellen; Bouman, Walter Pierre

2016-03-01

Previous research has reported high levels of non-suicidal self-injury (NSSI) in trans populations and younger age has been identified as a risk factor. To explore the prevalence of NSSI in a large group of young trans people and to identify risk factors for this group. Sociodemographic variables and measurements of NSSI (Self-Injury Questionnaire), psychopathology (Symptom Checklist-90-Revised), self-esteem (Rosenberg Self-Esteem Scale), victimization (Experiences of Transphobia Scale), interpersonal functioning (Inventory of Interpersonal Problems), and social support (Multidimensional Scale of Perceived Social Support). Two hundred sixty-eight young people attending a national gender clinic completed questionnaires assessing presence and frequency of NSSI and levels of general psychopathology, depression, anxiety, interpersonal problems, self-esteem, social support, transphobia, and information on hormone treatment. A lifetime presence of NSSI was identified in 46.3% of patients and 28.73% reported currently engaging in NSSI (within at least the past few months). Analyses showed that those with a lifetime presence of NSSI had significantly greater general psychopathology, lower self-esteem, had suffered more transphobia, and experienced greater interpersonal problems than those without NSSI. Findings were similar when comparing current with non-current NSSI. Overall, natal male patients reported less social support than natal female patients, but current NSSI was more common in natal female patients. Regression analyses confirmed that natal female gender and greater general psychopathology predicted current and lifetime NSSI. Further analyses confirmed that general psychopathology itself could be predicted by transphobic experiences, low self-esteem, and interpersonal problems, but not by the use of cross-sex hormones. These findings confirm that NSSI is common in trans youth and emphasize the need for interventions that decrease transphobia, increase social

Trans-sinusoidal maxillary distraction in three cleft patients.

NARCIS (Netherlands)

Wenghoefer, M.H.; Martini, M.; Nadjmi, N.; Schutyser, F.A.C.; Jagtman, A.K.; Bergé, S.J.

2006-01-01

The trans-sinusoidal maxillary distractor (TS-MD) was used to achieve maxillary advancement in three patients with repaired cleft lip and palate. After preoperative computer-aided planning of the distraction vectors, each TS-MD was bent on a stereolithographic model of the maxilla of the patient.

Electrochemical Evaluation of trans-Resveratrol Levels in Red Wine Based on the Interaction between Resveratrol and Graphene.

Science.gov (United States)

Liu, Lantao; Zhou, Yanli; Kang, Yiyu; Huang, Haihong; Li, Congming; Xu, Maotian; Ye, Baoxian

2017-01-01

trans -Resveratrol is often considered as one of the quality standards of red wine, and the development of a sensitive and reliable method for monitoring the trans -resveratrol levels in red wine is an urgent requirement for the quality control. Here, a novel voltammetric approach was described for probing trans -resveratrol using a graphene-modified glassy carbon (GC) electrode. The proposed electrode was prepared by one-step electrodeposition of reduced graphene oxide (ERGO) at a GC electrode. Compared with the bare GC electrode, the introduced graphene film on the electrode surface dramatically improved the sensitivity of the sensor response due to the π - π interaction between the graphene and trans -resveratrol. The developed sensor exhibited low detection limit of 0.2  μ M with wide linear range of 0.8-32  μ M and high stability. For the analysis of trans -resveratrol in red wine, the high anti-interference ability and the good recoveries indicated the great potential for practical applications.

Electrochemical Evaluation of trans-Resveratrol Levels in Red Wine Based on the Interaction between Resveratrol and Graphene

Directory of Open Access Journals (Sweden)

Lantao Liu

2017-01-01

Full Text Available trans-Resveratrol is often considered as one of the quality standards of red wine, and the development of a sensitive and reliable method for monitoring the trans-resveratrol levels in red wine is an urgent requirement for the quality control. Here, a novel voltammetric approach was described for probing trans-resveratrol using a graphene-modified glassy carbon (GC electrode. The proposed electrode was prepared by one-step electrodeposition of reduced graphene oxide (ERGO at a GC electrode. Compared with the bare GC electrode, the introduced graphene film on the electrode surface dramatically improved the sensitivity of the sensor response due to the π-π interaction between the graphene and trans-resveratrol. The developed sensor exhibited low detection limit of 0.2 μM with wide linear range of 0.8–32 μM and high stability. For the analysis of trans-resveratrol in red wine, the high anti-interference ability and the good recoveries indicated the great potential for practical applications.

Effects of irradiation on trans fatty acids formation in ground beef

International Nuclear Information System (INIS)

Brito, M.S.; Villavicencio, A.L.C.H.; Mancini-filho, Jorge

2002-01-01

In order to give the consumer the assurance that meat processed by irradiation is a safe product, a great deal of research has been developed in the world. The effect of irradiation on the hygienic quality of meat and meat products is considered as related to the control of meat-borne parasites of humans; elimination of pathogens from fresh meat and poultry; and elimination of pathogens from processed meat. Lipid oxidation and associated changes are the major causes of the quality deterioration of meat during storage. Irradiation of lipids induces the production of free radicals, which react with oxygen, leading to the formation of carbonyls, responsible for alterations in food nutritional and sensorial characteristics. Trans fatty acids are present in ground beef and can also be formed during its processing. Interestingly, the trans fatty acids, due to their chemical and physical characteristics, show more resistance to the oxidizing process. This property motivated us to investigate the level of the trans fatty acids, as well as the level of oxidation in irradiated ground beef. Irradiation of ground beef was performed by gamma rays from a 60 Co source. The applied radiation doses were 0; 1.0; 2.0; 3.0; 4.0; 5.0; 6.0; 7.0 and 8.0 kGy. Lipid peroxidation in terms of TBA number and carbonyl content was monitored during storage. The sample characteristics and trans fatty acids composition were measured, following irradiation and after 60 and 90 days of storage at -10 deg. C

Z-LASIK and Trans-PRK for correction of high-grade myopia: safety, efficacy, predictability and clinical outcomes.

Science.gov (United States)

Gershoni, Assaf; Mimouni, Michael; Livny, Eitan; Bahar, Irit

2018-03-12

The aim of the study was to examine the outcomes of transepithelial photorefractive keratectomy (Trans-PRK) and Femtosecond Laser-assisted in situ keratomileusis (Z-LASIK) for the correction of high myopia. A retrospective cohort study design was used. The study group included 792 eyes with high-grade myopia (- 6.0 diopters or higher) or high-grade myopia with astigmatism that were treated with Z-LASIK or Trans-PRK in 2013 through 2014 in an optical outpatient clinic of a large private medical service. The Trans-PRK group comprised of 674 eyes with a spherical equivalent (SE) of - 7.87 ± 1.46 and the Z-LASIK group comprised of 118 eyes with a SE of - 7.19 ± 0.81 (P PRK group was - 0.06 and - 0.02 in the Z-LASIK group (P = 0.545). Efficacy index values were 0.92 in the Trans-PRK group and 0.95 in the Z-LASIK group (P = 0.083), and corresponding safety index values were 0.95 and 0.97 (P = 0.056). An UCVA of 20/40 or better was achieved in 94.20% of eyes in the Trans-PRK group, and 98.31% in the Z-LASIK group (P = 0.063). The majority of eyes in both the Trans-PRK and Z-LASIK groups were within ± 0.5D of attempted correction: 59.35 and 64.71%, respectively (P = 0.271). Both Trans-PRK and Z-LASIK demonstrated excellent efficacy, safety and predictability profiles, with results comparable and in some cases superior to the current literature. Results of Z-LASIK were slightly better than those of Trans-PRK, though the preoperative SE of the latter was higher.

trans-Caryophyllene, a Natural Sesquiterpene, Causes Tracheal Smooth Muscle Relaxation through Blockade of Voltage-Dependent Ca2+ Channels

Directory of Open Access Journals (Sweden)

Jader Santos Cruz

2012-10-01

Full Text Available trans-Caryophyllene is a major component in the essential oils of various species of medicinal plants used in popular medicine in Brazil. It belongs to the chemical class of the sesquiterpenes and has been the subject of a number of studies. Here, we evaluated the effects of this compound in airway smooth muscle. The biological activities of trans-caryophyllene were examined in isolated bath organs to investigate the effect in basal tonus. Electromechanical and pharmacomechanical couplings were evaluated through the responses to K+ depolarization and exposure to acetylcholine (ACh, respectively. Isolated cells of rat tracheal smooth muscle were used to investigate trans-caryophyllene effects on voltage-dependent Ca2+ channels by using the whole-cell voltage-clamp configuration of the patch-clamp technique. trans-Caryophyllene showed more efficiency in the blockade of electromechanical excitation-contraction coupling while it has only minor inhibitory effect on pharmacomechanical coupling. Epithelium removal does not modify tracheal smooth muscle response elicited by trans-caryophyllene in the pharmacomechanical coupling. Under Ca2+-free conditions, pre-exposure to trans-caryophyllene did not reduce the contraction induced by ACh in isolated rat tracheal smooth muscle, regardless of the presence of intact epithelium. In the whole-cell configuration, trans-caryophyllene (3 mM, inhibited the inward Ba2+ current (IBa to approximately 50% of control levels. Altogether, our results demonstrate that trans-caryophyllene has anti-spasmodic activity on rat tracheal smooth muscle which could be explained, at least in part, by the voltage-dependent Ca2+ channels blockade.

Synthesis of cis - and trans-diisothiocyanato-bis(NHC) complexes of nickel(II) and applications in the Kumada-Corriu reaction

KAUST Repository

Jothibasu, Ramasamy

2010-09-13

Metathetical reaction of AgSCN with a series of trans-dihalido-bis(carbene) nickel(II) complexes in CH3CN readily afforded the novel diisothiocyanato-bis(carbene) complexes [Ni(NCS)2(NHC)2] (trans-2a, NHC = 1,3-diisopropylbenzimidazolin-2-ylidene; trans-2b, NHC = 1,3-diisobutylbenzimidazolin-2-ylidene; trans-2c, NHC = 1,3- dibenzylbenzimidazolin-2-ylidene; cis-2d, NHC = 1,3-di(2-propenyl) benzimidazolin-2-ylidene; cis-2e, NHC = 1-propyl-3-methylbenzimidazolin-2- ylidene) as greenish-yellow powders in moderate to good yields. While dihalido-bis(carbene) Ni(II) complexes exclusively form trans-complexes, a trans-cis isomerization occurs upon halido-isothiocyanato exchange with complexes bearing less bulky carbene ligands, i.e., cis-2d/e. DFT calculations indicated that this isomerization can be attributed to a reduced energy difference between trans- and cis-isomers of diisothiocyanato complexes. All complexes have been characterized by multinuclear NMR spectroscopy, ESI mass spectrometry, and X-ray diffraction analysis. A catalytic study revealed that cis-complexes generally exhibit greater activities in the Kumada-Corriu coupling reaction. © 2010 American Chemical Society.

Perfil lipídico de ovos desidratados com ênfase no seu teor de gorduras trans Lipid profile of dehydrated eggs with emphasis on the contents of trans fatty acids

Directory of Open Access Journals (Sweden)

Silce Adeline Danelon Guassi

2008-03-01

Full Text Available O presente trabalho objetivou a determinação do perfil lipídico de ovos integrais desidratados, bem como de gemas desidratadas, a fim de enfatizar seu conteúdo de ácidos graxos de configuração trans. A fração lipídica das amostras foi extraída com hexano/isopropanol e, a seguir, metilada. Os ácidos graxos foram identificados via cromatografia gasosa. Constatou-se que a natureza lipídica dos ovos tem caráter predominantemente insaturado: 63,65% dos lipídios totais nos ovos integrais e 62,63% nas gemas. Além disso, foram identificados apenas traços de gorduras trans (0,24% nos ovos integrais e 0,27% nas gemas.The objective of this work was to determine fatty acids composition in dehydrated eggs and egg yolks emphasizing its contents of trans fatty acids. The fatty acids fraction of the samples was extracted with hexane/isopropanol (3:2 and then methylated. The profile of the fatty acids was identified by gas chromatography with predominant evidence of insaturated character: 63.65 and 62.63% of the lipids were unsatureted in the eggs and in the egg yolks, respectively. Traces of trans fatty were also identified (0.24% in the hole eggs and 0.27% in the egg yolks.

La politización del cuerpo: subjetividades trans en resistencia

Directory of Open Access Journals (Sweden)

Manuel Roberto Escobar C.

2013-04-01

Full Text Available Se indaga por la experiencia del cuerpo trans (transgénero o transexual, cuya “artificialidad” interpela los órdenes del sujeto en la modernidad. El estudio se ubica en el contexto de dos ciudades latinoamericanas: México D. F. y Bogotá. Se plantea un vínculo entre la corporalidad trans, la biografía y los nombramientos de unas subjetividades que devienen tensión al orden somático moderno, tanto en sus versiones de docilidad y disciplinamiento, como también de hiperestesia y consumo. Así, la intervención singular sobre un cuerpo se torna en politización macro en el ámbito de lo público.

Regulatory Coherence and Standardization Mechanisms in the Trans-Pacific Partnership

Directory of Open Access Journals (Sweden)

Cai Phoenix X. F.

2016-12-01

Full Text Available This article posits a new taxonomy and framework for assessing regulatory coherence in the new generation of mega-regional, cross-cutting free trade agreements. Using the Trans-Pacific Partnership as the primary example, this article situates the rise of regulatory coherence within the current trade landscape, provides clear definitions of regulatory coherence, and argues that the real engine of regulatory coherence lies in the work of international standard setting organizations. This work has been little examined in the current literature. The article provides a detailed examination of the mechanics by which the Trans-Pacific Partnership promotes regulatory standardization and concludes with some normative implications and calls for future research.

Building coalitions: The interconnections between feminism and trans* activism in Spain.

Science.gov (United States)

Lucas Platero, R; Ortega-Arjonilla, Esther

2016-01-01

What made current Spanish feminism shift toward transfeminism? Based on in-depth interviews and literature reviews, we explore what factors facilitated the participation of trans* women in Spanish feminism. Tracing the history through relevant events such as the National Feminist Conferences, it becomes clear that trans* women participated in the 1993, 2000, and 2009 conferences, posing relevant issues regarding prostitution, transgenderism, and the political subject of feminism. Our research allows a break with global oppositional narratives, in which these movements are in conflict, and highlights the importance of understanding the vernacular nuances that take place in a particular geopolitical context.

Trigemino-cardiac reflex: occurrence of asystole during trans-sphenoidal adenomectomy: a case report

OpenAIRE

Jeon, Dae Geun; Kang, Bong Jin; Hur, Tae Won

2014-01-01

The trigemino-cardiac reflex has been reported to occur during various craniofacial surgeries or procedures including manipulation of the trigeminal ganglion, tumor resection in the cerebellopontine angle, various facial reconstructions and trans-sphenoidal adenomectomy. Regarding risk factors during trans-sphenoidal adenomectomy, invasiveness closely related to the size of tumor and the degree of manipulation of cavernous sinus wall have been reported. We report the case of a 40-year-old fem...

Structure, stability, and properties of the trans peroxo nitrate radical: the importance of nondynamic correlation.

Science.gov (United States)

Dutta, Achintya Kumar; Dar, Manzoor; Vaval, Nayana; Pal, Sourav

2014-02-27

We report a comparative single-reference and multireference coupled-cluster investigation on the structure, potential energy surface, and IR spectroscopic properties of the trans peroxo nitrate radical, one of the key intermediates in stratospheric NOX chemistry. The previous single-reference ab initio studies predicted an unbound structure for the trans peroxo nitrate radical. However, our Fock space multireference coupled-cluster calculation confirms a bound structure for the trans peroxo nitrate radical, in accordance with the experimental results reported earlier. Further, the analysis of the potential energy surface in FSMRCC method indicates a well-behaved minima, contrary to the shallow minima predicted by the single-reference coupled-cluster method. The harmonic force field analysis, of various possible isomers of peroxo nitrate also reveals that only the trans structure leads to the experimentally observed IR peak at 1840 cm(-1). The present study highlights the critical importance of nondynamic correlation in predicting the structure and properties of high-energy stratospheric NOx radicals.

Para-muscular and trans-muscular approaches to the lumbar inter-vertebral foramen: an anatomical comparison.

Science.gov (United States)

Poetscher, Arthur Werner; Ribas, Guilherme Carvalhal; Yasuda, Alexandre; Nishikuni, Koshiro

2005-03-01

Foraminal and extra-foraminal disc herniations comprise up to 11.7% of all lumbar disc herniations. Facetectomy, which had been the classic approach, is now recognized as cause of pain and instability after surgery. Otherwise, posterior lateral approaches through a trans-muscular or a para-muscular technique offer no significant damage to key structures for spinal stability. The surgical anatomy of these approaches has already been described, but they were not compared. In order to quantify the angle of vision towards the intervertebral foramen offered by each technique, 12 fresh cadavers were dissected and studied regarding these approaches. The angle presented by trans-muscular approach was wider in all studied lumbar levels. Surgery through the trans-muscular approach is performed with a better working angle, requiring a smaller resection of surrounding tissues. Therefore, minor surgical trauma can be expected. Our measurements support previously published data that point the trans-muscular approach as the best surgical option.

Biotransformation of d-Limonene to (+) trans-Carveol by Toluene-Grown Rhodococcus opacus PWD4 Cells

Science.gov (United States)

Duetz, Wouter A.; Fjällman, Ann H. M.; Ren, Shuyu; Jourdat, Catherine; Witholt, Bernard

2001-01-01

The toluene-degrading strain Rhodococcus opacus PWD4 was found to hydroxylate d-limonene exclusively in the 6-position, yielding enantiomerically pure (+) trans-carveol and traces of (+) carvone. This biotransformation was studied using cells cultivated in chemostat culture with toluene as a carbon and energy source. The maximal specific activity of (+) trans-carveol formation was 14.7 U (g of cells [dry weight])−1, and the final yield was 94 to 97%. Toluene was found to be a strong competitive inhibitor of the d-limonene conversion. Glucose-grown cells did not form any trans-carveol from d-limonene. These results suggest that one of the enzymes involved in toluene degradation is responsible for this allylic monohydroxylation. Another toluene degrader (Rhodococcus globerulus PWD8) had a lower specific activity but was found to oxidize most of the formed trans-carveol to (+) carvone, allowing for the biocatalytic production of this flavor compound. PMID:11375201

Trans-European transport networks influence on the regional development and urban systems: Serbian experience

Directory of Open Access Journals (Sweden)

Maksin-Mićić Marija

2004-01-01

Full Text Available The trans-European transport network has different effects at macro-regional, mezzo-regional and micro-regional level, and on urban systems development, and its effectiveness rises at the lower regional levels. Possible approaches to the trans-European transport network impact and effect survey and policy options have been pointed out. The importance of increased accessibility and mobility for regional expansion and for more balanced and polycentric system of city networks has been underlined. The question is how the new major transport infrastructure affects the development of functional complementarity between cities and regions. Changes of the spatial organization, utilization and structure of cities, as well as of social benefits and losses subsequent to impacts of trans-European transport corridor "X" on urban system Ćuprija-Jagodina-Paraćin at section Belgrade-Nis have been analysed. The new trans-European or major transport infrastructure does not per se create regional and urban system network development, although it can affect the conditions for the processes that create growth and development. The effects can be increased by co-ordination of measures of regional and urban policy, land use, transport and other policies. The guidances and options of urban systems and urban centres development policies in trans-European transport corridor, as well as possibilities to improve our planning system have been given. The necessary measure is the introduction of spatial impact assessment as sectorial policy instrument for the large transport infrastructure projects.

trans-Dichloridobis(3,4-dimethylpyridineplatinum(II

Directory of Open Access Journals (Sweden)

Alexander N. Chernyshev

2009-01-01

Full Text Available In the title compound, trans-[PtCl2(C7H9N2], the PtII atom is located on an inversion center and is coordinated by two 3,4-dimethylpyridine ligands and two chloride ligands, resulting in a typical slightly distorted square-planar geometry. The crystallographic inversion centre forces the value of the C—N—N—C torsion angle to be linear and the 3,4-dimethyl-pyridine ligands to be coplanar.

When Care and Concern Are Not Enough: School Personnel’s Development as Allies for Trans and Gender Non-Conforming Students

Directory of Open Access Journals (Sweden)

Robert A. Marx

2017-01-01

Full Text Available Trans people—and particularly trans youth—have come to the forefront of political and educational discussions, especially as legislation has aimed to ensure that school personnel act as enforcers of state-level policies targeting trans youth. For this reason, and because research demonstrates that youth in schools form attachments to and receive support from school personnel, our research looks at school personnel’s development as allies. By analyzing focus group data following a training workshop, we explore how participants understand their roles as allies to trans and gender non-conforming youth. We found that trans issues were salient and participants expressed new knowledge about and openness towards transgender youth, as well as care and concern for their wellbeing. Nonetheless, many participants retained frames of understanding that relied on trans people as Other and that situated their roles as allies through the frameworks of protection and care. We argue that these understandings of trans youth and the role of allies reinforces cisnormativity, and we push for a more nuanced understanding of allyship that moves beyond knowledge, beliefs, attitudes and intended behaviors as markers of allyship to ensure that allies do not reproduce cisnormativity even in their support of trans and gender non-conforming youth.

Control of Pollutants in the Trans-Boundary Area of Taihu Basin, Yangtze Delta

Directory of Open Access Journals (Sweden)

Xiao Wang

2016-12-01

Full Text Available This work focuses on pollution control in the trans-boundary area of Taihu Basin. Considering the unique characteristics of the river network in the study area, a new methodology of pollution control is proposed aiming at improving the water quality in the trans-boundary area and reducing conflicts between up and downstream regions. Based on monitoring data and statistical analysis, important trans-boundary cross sections identified by the regional government were selected as important areas for consideration in developing management objectives; using a 1-D mathematicmodel and an effective weight evaluation model, the trans-boundary effective control scope (TECS of the study area was identified as the scope for pollutant control; the acceptable pollution load was then estimated using an established model targeting bi-directional flow. The results suggest that the water environmental capacity for chemical oxygen demand (COD, in order to guarantee reaching the target water quality standard in the TECS, is 160,806 t/year, and amounts to 16,098 t/year, 3493 t/year, and 39,768 t/year for ammonia nitrogen, total nitrogen, and total phosphorus, respectively. Our study method and results have been incorporated into the local government management project, and have been proven to be useful in designing a pollution control strategy and management policy.

Production of Methyl Ester (Biodiesel from Used Cooking Oils via Trans-esterification process

Directory of Open Access Journals (Sweden)

Sameer Mohammed Salman

2016-06-01

Full Text Available Used cooking oil was undergoing trans-esterification reaction to produce biodiesel fuel. Method of production consisted of pretreatment steps, trans-esterification, separation, washing and drying. Trans-esterification of treated oils was studied at different operation conditions, the methanol to oil mole ratio were 6:1, 8:1, 10:1, and 12:1, at different temperature 30, 40, 50, and 60 º C, reaction time 40, 60, 80, and 120 minutes, amount of catalyst 0.5, 1, 1.5, and 2 wt.% based on oil and mixing speed 400 rpm. The maximum yield of biodiesel was 91.68 wt.% for treated oils obtained by trans-esterification reaction with 10:1 methanol to oil mole ratio, 60 º C reaction temperature, 80 minute reaction time and 0.5 wt.% of NaOH catalyst. The physical properties such as specific gravity, kinematic viscosity, acid number, flash point, pour point, and water content, were measured and compared them with American Standard Test Methods (ASTM D6751. The results of these properties for biodiesel product at (6:1, 8:1, 10:1, and 12:1 of methanol to oil mole ratio were within the range of American Standard Test Methods (ASTM D6751.

Oxidation of nitrite by a trans-dioxoruthenium(VI) complex: direct evidence for reversible oxygen atom transfer.

Science.gov (United States)

Man, Wai-Lun; Lam, William W Y; Wong, Wai-Yeung; Lau, Tai-Chu

2006-11-15

Reaction of trans-[Ru(VI)(L)(O)(2)](2+) (1, L = 1,12-dimethyl-3,4:9,10-dibenzo-1,12-diaza-5,8-dioxacyclopentadecane, a tetradentate macrocyclic ligand with N(2)O(2) donor atoms) with nitrite in aqueous solution or in H(2)O/CH(3)CN produces the corresponding (nitrato)oxoruthenium(IV) species, trans-[Ru(IV)(L)(O)(ONO(2))](+) (2), which then undergoes relatively slow aquation to give trans-[Ru(IV)(L)(O)(OH(2))](2+). These processes have been monitored by both ESI/MS and UV/vis spectrophotometry. The structure of trans-[Ru(IV)(L)(O)(ONO(2))](+) (2) has been determined by X-ray crystallography. The ruthenium center adopts a distorted octahedral geometry with the oxo and the nitrato ligands trans to each other. The Ru=O distance is 1.735(3) A, the Ru-ONO(2) distance is 2.163(4) A, and the Ru-O-NO(2) angle is 138.46(35) degrees . Reaction of trans-[Ru(VI)(L)((18)O)(2)](2+) (1-(18)O(2)) with N(16)O(2)(-) in H(2)O/CH(3)CN produces the (18)O-enriched (nitrato)oxoruthenium(IV) species 2-(18)O(2). Analysis of the ESI/MS spectrum of 2-(18)O(2) suggests that scrambling of the (18)O atoms has occurred. A mechanism that involves linkage isomerization of the nitrato ligand and reversible oxygen atom transfer is proposed.

TransQUAL Online User's Guide: Improving Student Transitions to Life after School. Version 3.0

Science.gov (United States)

Brewer, David

2006-01-01

TransQUAL Online is designed to assist school districts collaborate with others and continuously improve their transition practices for youth. TransQUAL incorporates New York State Education Department Transition Quality Indicators (TQI), based on the work of Paula Kolher from Western Michigan University. The TQI assesses program structure,…

Experiences of female partners of masculine-identifying trans persons.

Science.gov (United States)

Theron, Liesl; Collier, Kate L

2013-01-01

This paper explores the intimate relationship experiences of the cisgender (i.e., not transgender) female partners of masculine-identifying transgender persons, with a particular focus on these partners' self-understanding of their sexual orientation. Limited research about this topic has been conducted to date. Semi-structured interviews were conducted with eight South African women who are or have been cisgender female partners of masculine-identifying trans persons. Although the interviews showed that the relationship experiences of female partners of masculine-identifying trans persons are diverse, several common themes emerged in the narratives. The way that participants labelled their sexual orientation did not change from before to after their relationship with a transgender partner. The participants reported varied family and community responses to their relationships. Specific emotional and informational support needs for women with transgender partners were identified.

trans-Carbonylchloridobis[diphenyl(4-vinylphenylphosphane-κP]rhodium(I

Directory of Open Access Journals (Sweden)

Reinout Meijboom

2012-05-01

Full Text Available In the title compound, trans-[RhCl(C20H17P2(CO], the RhI atom is situated on a center of symmetry, resulting in a statistical 1:1 disorder of the chloride [Rh—Cl = 2.383 (2 Å] and carbonyl [Rh—C = 1.752 (7 Å] ligands. The distorted trans square-planar environment is completed by two P atoms [Rh—P = 2.3251 (4 Å] from two diphenyl(4-vinylphenylphosphane ligands. The vinyl group is disordered over two sets of sites in a 0.668 (10:0.332 (10 ratio. The crystal packing exhibits weak C—H...Cl and C—H...O hydrogen bonds and π–π interactions between the phenyl rings of neighbouring molecules, with a centroid–centroid distance of 3.682 (2 Å.

Identifying cis-mediators for trans-eQTLs across many human tissues using genomic mediation analysis.

Science.gov (United States)

Yang, Fan; Wang, Jiebiao; Pierce, Brandon L; Chen, Lin S

2017-11-01

The impact of inherited genetic variation on gene expression in humans is well-established. The majority of known expression quantitative trait loci (eQTLs) impact expression of local genes ( cis -eQTLs). More research is needed to identify effects of genetic variation on distant genes ( trans -eQTLs) and understand their biological mechanisms. One common trans -eQTLs mechanism is "mediation" by a local ( cis ) transcript. Thus, mediation analysis can be applied to genome-wide SNP and expression data in order to identify transcripts that are " cis -mediators" of trans -eQTLs, including those " cis -hubs" involved in regulation of many trans -genes. Identifying such mediators helps us understand regulatory networks and suggests biological mechanisms underlying trans -eQTLs, both of which are relevant for understanding susceptibility to complex diseases. The multitissue expression data from the Genotype-Tissue Expression (GTEx) program provides a unique opportunity to study cis -mediation across human tissue types. However, the presence of complex hidden confounding effects in biological systems can make mediation analyses challenging and prone to confounding bias, particularly when conducted among diverse samples. To address this problem, we propose a new method: Genomic Mediation analysis with Adaptive Confounding adjustment (GMAC). It enables the search of a very large pool of variables, and adaptively selects potential confounding variables for each mediation test. Analyses of simulated data and GTEx data demonstrate that the adaptive selection of confounders by GMAC improves the power and precision of mediation analysis. Application of GMAC to GTEx data provides new insights into the observed patterns of cis -hubs and trans -eQTL regulation across tissue types. © 2017 Yang et al.; Published by Cold Spring Harbor Laboratory Press.

TransCut: interactive rendering of translucent cutouts.

Science.gov (United States)

Li, Dongping; Sun, Xin; Ren, Zhong; Lin, Stephen; Tong, Yiying; Guo, Baining; Zhou, Kun

2013-03-01

We present TransCut, a technique for interactive rendering of translucent objects undergoing fracturing and cutting operations. As the object is fractured or cut open, the user can directly examine and intuitively understand the complex translucent interior, as well as edit material properties through painting on cross sections and recombining the broken pieces—all with immediate and realistic visual feedback. This new mode of interaction with translucent volumes is made possible with two technical contributions. The first is a novel solver for the diffusion equation (DE) over a tetrahedral mesh that produces high-quality results comparable to the state-of-art finite element method (FEM) of Arbree et al. but at substantially higher speeds. This accuracy and efficiency is obtained by computing the discrete divergences of the diffusion equation and constructing the DE matrix using analytic formulas derived for linear finite elements. The second contribution is a multiresolution algorithm to significantly accelerate our DE solver while adapting to the frequent changes in topological structure of dynamic objects. The entire multiresolution DE solver is highly parallel and easily implemented on the GPU. We believe TransCut provides a novel visual effect for heterogeneous translucent objects undergoing fracturing and cutting operations.

Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent.

Science.gov (United States)

Tetri, Laura H; Basaranoglu, Metin; Brunt, Elizabeth M; Yerian, Lisa M; Neuschwander-Tetri, Brent A

2008-11-01

The aims of this study were to determine whether combining features of a western lifestyle in mice with trans fats in a high-fat diet, high-fructose corn syrup in the water, and interventions designed to promote sedentary behavior would cause the hepatic histopathological and metabolic abnormalities that characterize nonalcoholic steatohepatitis (NASH). Male C57BL/6 mice fed ad libitum high-fat chow containing trans fats (partially hydrogenated vegetable oil) and relevant amounts of a high-fructose corn syrup (HFCS) equivalent for 1-16 wk were compared with mice fed standard chow or mice with trans fats or HFCS omitted. Cage racks were removed from western diet mice to promote sedentary behavior. By 16 wk, trans fat-fed mice became obese and developed severe hepatic steatosis with associated necroinflammatory changes. Plasma alanine aminotransferase levels increased, as did liver TNF-alpha and procollagen mRNA, indicating an inflammatory and profibrogenic response to injury. Glucose intolerance and impaired fasting glucose developed within 2 and 4 wk, respectively. Plasma insulin, resistin, and leptin levels increased in a profile similar to that seen in patients with NASH. The individual components of this diet contributed to the phenotype independently; isocaloric replacement of trans fats with lard established that trans fats played a major role in promoting hepatic steatosis and injury, whereas inclusion of HFCS promoted food consumption, obesity, and impaired insulin sensitivity. Combining risk factors for the metabolic syndrome by feeding mice trans fats and HFCS induced histological features of NASH in the context of a metabolic profile similar to patients with this disease. Because dietary trans fats promoted liver steatosis and injury, their role in the epidemic of NASH needs further evaluation.

Trans generational ethics: protecting future generations against nuclear waste hazards. Some ethical considerations

International Nuclear Information System (INIS)

Cornelis, G.C.

2002-01-01

This paper describes the activities launched at SCK x CEN, intended to explore ethical and other non-technical aspects when dealing with the time scales considered in the high-level waste disposal program. Especially the issues of retrievability and precaution will be focused on which will be philosophically contextualised. Many questions will be raised in order to sensitize all stakeholders for the trans-disciplinary character of the trans-generational problem at hand. (author)

Trans-Agency Early-Life Exposures and Cancer Working Group

Science.gov (United States)

The Trans-Agency Early-Life Exposures and Cancer Working Group promotes integration of early-life events and exposures into public health cancer research, control, prevention, and policy strategies to reduce the cancer burden in the United States and globally.

Characterization of chromosome instability in interspecific somatic hybrids obtained by X-ray fusion between potato (Solanum tuberosum L.) and S. brevidens Phil

International Nuclear Information System (INIS)

Fehér, A.; Preiszner, J.; Litkey, Z.; Csanádi, G; Dudits, D.

1992-01-01

Asymmetric somatic hybrids between Solanum tuberosum L. and S. brevidens Phil. have been obtained via the fusion of protoplasts from potato leaves and from cell suspension culture of S. brevidens. The wild Solanum species served as donor after irradiation of its protoplasts with a lethal X-ray dose (200 Gy). Selection of the putative hybrids was based on the kanamycin-resistance marker gene previously introduced into the genome of Solanum brevidens by Agrobacterium-mediated gene transfer. Thirteen out of the 45 selected clones exhibited reduced morphogenic potential. The morphological abnormalities of the regenerated plantlets were gradually eliminated during the extended in vitro culture period. Cytological investigations revealed that the number of chromosomes in the cultured S. brevidens cells used as protoplast source ranged between 28-40 instead of the basic 2n=24 value. There was a high degree of aneuploidy in all of the investigated hybrid clones, and at least 12 extra chromosomes were observed in addition to the potato chromosomes (2n=48). Interand intraclonal variation and segregation during vegetative propagation indicated the genetic instability of the hybrids, which can be ascribed to the pre-existing and X-ray irradiation-induced chromosomal abnormalities in the donor S. brevidens cells. The detection of centromeric chromosome fragments and long, poly-constrictional chromosomes in cytological preparations as well as non-parental bands in Southern hybridizations with restriction fragment length polymorphism (RFLP) markers revealed extensive chromosome rearrangements in most of the regenerated clones. On the basis of the limited number of RFLP probes used, preferential loss of S. brevidens specific markers with a non-random elimination pattern could be detected in hybrid regenerants

DESENVOLVIMENTO, LIBERDADE E GÊNERO: EXPERIÊNCIAS TRANS / DEVELOPMENT, FREEDOM AND GENDER: TRANS EXPERIENCES

Directory of Open Access Journals (Sweden)

Tuanny Soeiro Sousa

2017-04-01

Full Text Available This essay seeks to make an examination on how the gender category influences in the development process, based on the concept of development as freedom by Amartya Sen. In view of this purpose, we analyze the main human rights violations suffered by travesties and transsexuals due to the female and male identity construction in contrast to social norms establishing hierarchical positions of men and women as constituents of male and female categories. In other words, conflicts made in the wake of gender relations. This study is the result of a literature review and analysis of data on homophobic violence against trans experience.

Chemical and Nutritional Composition of Copao Fruit (Eulychnia acida Phil. Unswe Thee Environmental Conditions in the Coquimbo Region Características Químicas y Composición Nutricional de los Frutos de Copao (Eulychnia acida Phil. Bajo tres Condiciones Ambientales de la Región de Coquimbo

Directory of Open Access Journals (Sweden)

Lilia Masson S

2011-12-01

Full Text Available Copao (Eulychnia acida Phil. is an endemic arborescent cactus restricted mainly to the semi-arid Coquimbo Region (29°54'28" S, 71°15'15" W, Chile. The area of distribution is from sea level to 1200 m.a.s.l. The edible fruit called rumpa is generally round, with green or pink peel and small scales on its surface, showing wide variability in size and weight. The aim of this work was to characterize the rumpa harvested in January 2009 and 2010 in three sectors of Coquimbo Region to determine chemical and nutritional composition in three fractions: pulp with seeds, juice, and peel. The research showed that this fruit is a good natural source of mainly soluble dietary fiber, which has a jellied texture and is present in the three fractions analyzed: 2% for juice, 3% for pulp with seeds, and approximately 5% for peel, making it potentially a good source of hydrocolloids for the food industry. The fruit is also a good source of vitamin C; around 55 mg 100 g-1 in peel, and 30 mg 100 g-1 in pulp with seeds and juice, values considered high compared to 18 mg 100 g-1 for prickly pear (Opuntiaficus-indica [L.] Mill. The main minerals were: K, Mg, Ca, and P. Total polyphenols and betalain pigments were also determined in the pulp with seeds and pink peel fractions, respectively. The nutritional characteristics, together with its high water content of around 96%, make rumpa a promising raw material for agro-industrial development of natural juices or isotonic drinks. This characterization helps in the recovery of an endemic native species by reducing potential threats to destroy wild populations of E. acid, especially near agricultural areas, and by promoting habitat conservation of the species in the region.El copao (Eulychnia acida Phil. es un cactus arborescente endémico restringido principalmente a la región semi árida de Coquimbo (29°54'28" S, 71°15'15" O, Chile. El área de distribución comprende desde el nivel del mar hasta los 1200 m de

Electrochemical Evaluation of trans-Resveratrol Levels in Red Wine Based on the Interaction between Resveratrol and Graphene

OpenAIRE

Liu, Lantao; Zhou, Yanli; Kang, Yiyu; Huang, Haihong; Li, Congming; Xu, Maotian; Ye, Baoxian

2017-01-01

trans-Resveratrol is often considered as one of the quality standards of red wine, and the development of a sensitive and reliable method for monitoring the trans-resveratrol levels in red wine is an urgent requirement for the quality control. Here, a novel voltammetric approach was described for probing trans-resveratrol using a graphene-modified glassy carbon (GC) electrode. The proposed electrode was prepared by one-step electrodeposition of reduced graphene oxide (ERGO) at a GC electrode....

Computer code TRANS-ACE predicting for fire and explosion accidents in nuclear fuel reprocessing plants

International Nuclear Information System (INIS)

Abe, Hitoshi; Nishio; Gunji; Naito, Yoshitaka

1993-11-01

The accident analysis code TRANS-ACE was developed to evaluate the safety of a ventilation system in a reprocessing plant in the event of fire and explosion accidents. TRANS-ACE can evaluate not only the integrity of a ventilation system containing HEPA filters but also the source term of radioactive materials for release out of a plant. It calculates the temperature, pressure, flow rate, transport of combustion materials and confinement of radioactive materials in the network of a ventilation system that might experience a fire or explosion accident. TRANS-ACE is based on the one-dimensional compressible thermo-fluid analysis code EVENT developed by Los Alamos National Laboratory (LANL). Calculational functions are added for the radioactive source term, heat transfer and radiation to cell and duct walls and HEPA filter integrity. For the second edition in the report, TRANS-ACE has been improved incorporating functions for the initial steady-state calculation to determine the flow rates, pressure drops and temperature in the network before an accident mode analysis. It is also improved to include flow resistance calculations of the filters and blowers in the network and to have an easy to use code by simplifying the input formats. This report is to prepare an explanation of the mathematical model for TRANS-ACE code and to be the user's manual. (author)

Coastal livelihood transitions under globalization with implications for trans-ecosystem interactions.

Science.gov (United States)

Kramer, Daniel B; Stevens, Kara; Williams, Nicholas E; Sistla, Seeta A; Roddy, Adam B; Urquhart, Gerald R

2017-01-01

Anthropogenic threats to natural systems can be exacerbated due to connectivity between marine, freshwater, and terrestrial ecosystems, complicating the already daunting task of governance across the land-sea interface. Globalization, including new access to markets, can change social-ecological, land-sea linkages via livelihood responses and adaptations by local people. As a first step in understanding these trans-ecosystem effects, we examined exit and entry decisions of artisanal fishers and smallholder farmers on the rapidly globalizing Caribbean coast of Nicaragua. We found that exit and entry decisions demonstrated clear temporal and spatial patterns and that these decisions differed by livelihood. In addition to household characteristics, livelihood exit and entry decisions were strongly affected by new access to regional and global markets. The natural resource implications of these livelihood decisions are potentially profound as they provide novel linkages and spatially-explicit feedbacks between terrestrial and marine ecosystems. Our findings support the need for more scientific inquiry in understanding trans-ecosystem tradeoffs due to linked-livelihood transitions as well as the need for a trans-ecosystem approach to natural resource management and development policy in rapidly changing coastal regions.

Trans individuals' facilitative coping: An analysis of internal and external processes.

Science.gov (United States)

Budge, Stephanie L; Chin, Mun Yuk; Minero, Laura P

2017-01-01

Existing research on trans individuals has primarily focused on their negative experiences and has disproportionately examined coming-out processes and identity development stages. Using a grounded theory approach, this qualitative study sought to examine facilitative coping processes among trans-identified individuals. Facilitative coping was operationalized as processes whereby individuals seek social support, learn new skills, change behaviors to positively adapt, and find alternative means to seek personal growth and acceptance. The sample included 15 participants who self-identified with a gender identity that was different from their assigned sex at birth. Results yielded a total of nine overarching themes: Accepting Support from Others, Actions to Increase Protection, Active Engagement Throughout the Transition Process, Actively Seeking Social Interactions, Engaging in Exploration, Internal Processes Leading to Self-Acceptance, Self-Efficacy, Shifts Leading to Embracing Change and Flexibility, and Utilization of Agency. Based on the analysis, a theoretical model emerged that highlighted the importance of internal and external coping processes in facilitating gender identity development and navigating stressors among trans individuals. Clinical implications focusing on how to implement facilitative coping processes are discussed. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Coastal livelihood transitions under globalization with implications for trans-ecosystem interactions.

Directory of Open Access Journals (Sweden)

Daniel B Kramer

Full Text Available Anthropogenic threats to natural systems can be exacerbated due to connectivity between marine, freshwater, and terrestrial ecosystems, complicating the already daunting task of governance across the land-sea interface. Globalization, including new access to markets, can change social-ecological, land-sea linkages via livelihood responses and adaptations by local people. As a first step in understanding these trans-ecosystem effects, we examined exit and entry decisions of artisanal fishers and smallholder farmers on the rapidly globalizing Caribbean coast of Nicaragua. We found that exit and entry decisions demonstrated clear temporal and spatial patterns and that these decisions differed by livelihood. In addition to household characteristics, livelihood exit and entry decisions were strongly affected by new access to regional and global markets. The natural resource implications of these livelihood decisions are potentially profound as they provide novel linkages and spatially-explicit feedbacks between terrestrial and marine ecosystems. Our findings support the need for more scientific inquiry in understanding trans-ecosystem tradeoffs due to linked-livelihood transitions as well as the need for a trans-ecosystem approach to natural resource management and development policy in rapidly changing coastal regions.

Trans-dimensional matched-field geoacoustic inversion with hierarchical error models and interacting Markov chains.

Science.gov (United States)

Dettmer, Jan; Dosso, Stan E

2012-10-01

This paper develops a trans-dimensional approach to matched-field geoacoustic inversion, including interacting Markov chains to improve efficiency and an autoregressive model to account for correlated errors. The trans-dimensional approach and hierarchical seabed model allows inversion without assuming any particular parametrization by relaxing model specification to a range of plausible seabed models (e.g., in this case, the number of sediment layers is an unknown parameter). Data errors are addressed by sampling statistical error-distribution parameters, including correlated errors (covariance), by applying a hierarchical autoregressive error model. The well-known difficulty of low acceptance rates for trans-dimensional jumps is addressed with interacting Markov chains, resulting in a substantial increase in efficiency. The trans-dimensional seabed model and the hierarchical error model relax the degree of prior assumptions required in the inversion, resulting in substantially improved (more realistic) uncertainty estimates and a more automated algorithm. In particular, the approach gives seabed parameter uncertainty estimates that account for uncertainty due to prior model choice (layering and data error statistics). The approach is applied to data measured on a vertical array in the Mediterranean Sea.

Trans-European transport networks influence on the regional development and urban systems: Serbian experience

Directory of Open Access Journals (Sweden)

Maksin-Mićić Marija

2004-01-01

Full Text Available The trans-European transport network has different effects at macro regional mezzo-regional and micro-regional level, and its effectiveness rises with the lower regional levels. Possible approaches to the trans-European transport network impact and effect survey and policy options have been pointed out. The importance of increased accessibility and mobility for regional expansion and for a more balanced and polycentric system of city networks has been underlined. Changes in the spatial organization utilization and structure of cities, as well as in social benefits and losses subsequent to impacts of trans-European transport corridor "X" section Belgrade-Niš have been analyzed. The new trans-European or major transport infrastructure does not per se create regional and urban system network development, although it can affect the conditions for the processes that create growth and development. The effects can be increased by co-ordination of measures of regional, spatial and urban policy, land use transport, environmental and other policies. The necessary measure is the introduction of spatial impact assessment as sartorial policy instrument for the large transport infrastructure plans and projects.

The Oral Bioavailability of Trans-Resveratrol from a Grapevine-Shoot Extract in Healthy Humans is Significantly Increased by Micellar Solubilization.

Science.gov (United States)

Calvo-Castro, Laura A; Schiborr, Christina; David, Franziska; Ehrt, Heidi; Voggel, Jenny; Sus, Nadine; Behnam, Dariush; Bosy-Westphal, Anja; Frank, Jan

2018-05-01

Grapevine-shoot extract Vineatrol30 contains abundant resveratrol monomers and oligomers with health-promoting potential. However, the oral bioavailability of these compounds in humans is low (˂1-2%). The aim of this study was to improve the oral bioavailability of resveratrol from vineatrol by micellar solubilization. Twelve healthy volunteers (six women, six men) randomly ingested a single dose of 500 mg vineatrol (30 mg trans-resveratrol, 75 mg trans-ε-viniferin) as native powder or liquid micelles. Plasma and urine were collected at baseline and over 24 h after intake. Resveratrol and viniferin were analyzed by HPLC. The area under the plasma concentration-time curve (AUC) and mean maximum plasma trans-resveratrol concentrations were 5.0-fold and 10.6-fold higher, respectively, after micellar supplementation relative to the native powder. However, no detectable amounts of trans-ε-viniferin were found in either plasma or urine. The transepithelial permeability of trans-resveratrol and trans-ε-viniferin across differentiated Caco-2 monolayers was consistent to the absorbed fractions in vivo. The oral bioavailability of trans-resveratrol from the grapevine-shoot extract Vineatrol30 was significantly increased using a liquid micellar formulation, without any treatment-related adverse effects, making it a suitable system for improved supplementation of trans-resveratrol. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Correlation of Erythrocyte Trans Fatty Acids with Ovulatory Disorder Infertility in Polycystic Ovarian Syndrome

Directory of Open Access Journals (Sweden)

Aisa Ghaffarzad

2014-07-01

Full Text Available Trans fatty acids are considered to be the important modifiable factor of the ovulatory infertility disorder. The purpose of this study was to test the hypothesis that higher trans fatty acids of erythrocytes (RBC are associated with the risk of ovulatory infertility disorder in polycystic ovarian syndrome (PCOS. Thirty five infertile women with polycystic ovarian syndrome, defined by AES criteria and 29 age-matched healthy women as a control group were recruited for the study. After physical measurements and nutritional assessment, blood samples were collected. Fasting serum glucose and insulin were measured, and then insulin resistance was calculated by homeostasis model assessment (HOMA-IR. Erythrocyte fatty acids were measured by gas chromatography. The patients group had higher waist circumference (WC, insulin levels, HOMA-IR than controls (p< 0.05. Also, case group had lower percentage of normal BMI (BMI<25, physical activity and education levels than healthy women (p< 0.05. Among RBC trans fatty acids only trans linoleate (18:2t were significantly higher in case group than control women (p= 0.019. PCOS group tended to consume more food rich in TFAs than the control group. Logistic regression analysis also showed that only 18:2t is positively associated with risk of ovulatory disorder infertility in PCOS (OR= 1.225, 95% CI. 1.024-1.465; P= 0.026, which was not affected after adjustment for BMI, physical activity and education levels. The results suggested that RBC trans fatty acids might be a predictor of increased risk for ovulatory infertility disorder in women with PCOS.

Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation

DEFF Research Database (Denmark)

Herth, Matthias Manfred; Andersen, Valdemar L.; Lehel, Szabolcs

2013-01-01

Tetrazine–trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful developm......Tetrazine–trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful...

Image guidance in trans-sphenoidal surgery for giant pituitary adenomas: Luxury or necessity?

OpenAIRE

Deepak Agrawal

2012-01-01

Background: In spite of availability of image guidance (neuronavigation) at major centers around the world, most trans-sphenoidal surgeries for pituitary adenomas continue to be done under fluoroscopic control. On the other hand, the high mortality and morbidity for giant pituitary adenomas is mainly due to inadequate tumor removal. Aims and Objectives: The objective of this study was to study to utility of image guidance in trans-sphenoidal surgeries for optimizing tumor removal in giant pit...

tranSMART: An Open Source and Community-Driven Informatics and Data Sharing Platform for Clinical and Translational Research.

Science.gov (United States)

Athey, Brian D; Braxenthaler, Michael; Haas, Magali; Guo, Yike

2013-01-01

tranSMART is an emerging global open source public private partnership community developing a comprehensive informatics-based analysis and data-sharing cloud platform for clinical and translational research. The tranSMART consortium includes pharmaceutical and other companies, not-for-profits, academic entities, patient advocacy groups, and government stakeholders. The tranSMART value proposition relies on the concept that the global community of users, developers, and stakeholders are the best source of innovation for applications and for useful data. Continued development and use of the tranSMART platform will create a means to enable "pre-competitive" data sharing broadly, saving money and, potentially accelerating research translation to cures. Significant transformative effects of tranSMART includes 1) allowing for all its user community to benefit from experts globally, 2) capturing the best of innovation in analytic tools, 3) a growing 'big data' resource, 4) convergent standards, and 5) new informatics-enabled translational science in the pharma, academic, and not-for-profit sectors.

Transient nerve damage following intubation for trans-sphenoidal hypophysectomy

NARCIS (Netherlands)

Evers, KA; Eindhoven, GB; Wierda, JMKH

1999-01-01

Purpose: To describe a case of transient lingual and hypoglossal nerve damage following intubation for a transsphenoidal hypophysectomy. Clinical features: A 56-yr-old acromegalic man was scheduled for trans-sphenoidal hypophysectomy. He had been treated with octreotide six months previously which

SupraTrans II. Test drive facility for a superconductor-based maglev train; SupraTrans II. Fahrversuchsanlage fuer eine Magnetbahn mit Supraleitern

Energy Technology Data Exchange (ETDEWEB)

Kuehn, Lars; Haas, Oliver de [evico GmbH, Dresden (Germany); Berger, Dietmar; Schultz, Ludwig [IFW Dresden (Germany); Olsen, Henning; Roehlig, Steffen [ELBAS Elektrische Bahnsysteme Ingenieur-Gesellschaft mbH, DNV company, Dresden (Germany)

2012-08-15

The SupraTrans system was further developed and a test drive facility built up in Dresden. The latter permits complex drive tests to be made as well as the testing of components. Compared to the demonstrator, the facility is characterized by a higher loadability, higher speeds and a completely contactless energy transmission. (orig.)

The Evolution of Trans-Skeletal Method Osteosynthesis | Omeonu ...

African Journals Online (AJOL)

OBJECTIVE: The purpose of this article is to give a brief overview of the history of trans-skeletal method ostheosynthesis as it relates to the evolution of the Ilizarov external fixation device. BODY: The pin frame external fixators originated from the idea of bone reduction with pins fixed to fragments before applying the plaster ...

Paternally expressed Peg3 controls maternally expressed Zim1 as a trans factor.

Directory of Open Access Journals (Sweden)

An Ye

Full Text Available The expression of two adjacent imprinted genes, Peg3 and Zim1, is inversely correlated: down-regulation of Peg3 coinciding with up-regulation of Zim1. The current study characterized this inverse correlation using a mutant allele targeting Peg3. According to the results, the mutation on the paternal allele of Peg3 resulted in a dramatic increase in the transcription levels of the maternal allele of Zim1, suggesting the involvement of unknown trans factors in this trans-allelic event. Subsequent ChIP experiments revealed that the protein encoded by Peg3 itself binds to the zinc finger exon of Zim1, which is modified with the repression mark H3K9me3. Interestingly, the levels of H3K9me3 on Zim1 are also reduced in the mutant cells lacking the protein PEG3, suggesting potential roles for PEG3 in establishing H3K9me3 on Zim1. Reintroducing PEG3 into the mutant cell restored down-regulation of Zim1, confirming the predicted repressor role for Peg3 on Zim1. Overall, these results demonstrated that paternally expressed Peg3 controls maternally expressed Zim1 as a trans factor. The current study also provides the first case for the trans-allelic interaction of two oppositely imprinted genes through their gene products.

Preoperative clonidine use in trans-sphenoidal pituitary adenoma surgeries - a randomized controlled trial.

Science.gov (United States)

Bajaj, Jitin; Mittal, Radhe Shyam; Sharma, Achal

2017-02-01

Pituitary masses are common lesions accounting for about 15-20% of all brain tumours. Oozing blood is an annoyance in microscopic sublabial trans-sphenoidal approach for these masses. There have been many ways of reducing the ooze, having their own pros and cons. To find out the efficacy and safety of clonidine in reducing blood loss in pituitary adenoma surgery through a randomized masked trial. It was a prospective randomized controlled trial done. Total 50 patients of pituitary adenomas were randomized into two groups. Group A (25 patients) was given 200 μg clonidine orally, while Group B (25 patients) was given placebo. Surgeon, anaesthesiologist and patient were blinded for the trial. Sublabial trans-septal trans-sphenoidal approach to sella and excision of mass was performed in each patient. Patients were studied for pre-, intra- and post-operative blood pressure and heart rate, pre- and post-operative imaging findings, intra-operative blood loss, bleeding grading by surgeon, surgeon's satisfaction about condition of specific part and quality of surgical field, operative time and extent of resection. Blood loss during the surgery, operative time and bleeding grading by the surgeon were found significantly less in the clonidine group, while quality of surgical field, condition of the specific part and extent of resection were found significantly better in the clonidine group (p value trans-sphenoidal microscopic pituitary adenoma surgeries.

Fatty acid composition and contents of trans monounsaturated fatty acids in frying fats, and in margarines and shortenings marketed in Denmark

DEFF Research Database (Denmark)

Ovesen, L.; Leth, Torben; Hansen, K.

1998-01-01

This study examined trans monounsaturated fatty acid contents in all margarines and shortenings marketed in Denmark, and in frying fats used by the fast-food restaurants Burger King and McDonald's. Trans C-18:1 content was 4.1 +/- 3.8% (g per 100 g fatty acids) in hard margarines, significantly...... of trans long-chain fatty acids. Both fast-food frying fats contained large amounts of trans C-18:1, 21.9 +/- 2.9% in Burger King and 16.6 +/- 0.4% in McDonald's. In Denmark the per capita supply of trans C-18:1 from margarines and shortenings and frying fats has decreased steadily during recent years...

Triplet State Resonance Raman Spectrum of all-trans-diphenylbutadiene

DEFF Research Database (Denmark)

Wilbrandt, Robert Walter; Grossman, W.E.L.; Killough, P.M

1984-01-01

The resonance Raman spectrum of all-trans-diphenylbutadiene (DPB) in its ground state and the resonance Raman spectrum (RRS) of DPB in its short-lived electronically excited triplet state are reported. Transient spectra were obtained by a pump-probe technique using two pulsed lasers...

Obtenção de gorduras low trans por interesterificação quimica

OpenAIRE

Miluska Castillo Caceres

2008-01-01

Resumo: As gorduras trans, principalmente presentes nos alimentos industrializados como biscoitos, gorduras para fritura, margarinas, entre outros, são resultados da hidrogenação parcial, processo utilizado pela indústria há mais de 100 anos Abstract:Trans fats, most contained within food industrialized and biscuits, fats for frying, margarine and others, are the result of partial hydrogenation, a process used by the industry for more than 100 years

TransAtlasDB: an integrated database connecting expression data, metadata and variants

Science.gov (United States)

Adetunji, Modupeore O; Lamont, Susan J; Schmidt, Carl J

2018-01-01

Abstract High-throughput transcriptome sequencing (RNAseq) is the universally applied method for target-free transcript identification and gene expression quantification, generating huge amounts of data. The constraint of accessing such data and interpreting results can be a major impediment in postulating suitable hypothesis, thus an innovative storage solution that addresses these limitations, such as hard disk storage requirements, efficiency and reproducibility are paramount. By offering a uniform data storage and retrieval mechanism, various data can be compared and easily investigated. We present a sophisticated system, TransAtlasDB, which incorporates a hybrid architecture of both relational and NoSQL databases for fast and efficient data storage, processing and querying of large datasets from transcript expression analysis with corresponding metadata, as well as gene-associated variants (such as SNPs) and their predicted gene effects. TransAtlasDB provides the data model of accurate storage of the large amount of data derived from RNAseq analysis and also methods of interacting with the database, either via the command-line data management workflows, written in Perl, with useful functionalities that simplifies the complexity of data storage and possibly manipulation of the massive amounts of data generated from RNAseq analysis or through the web interface. The database application is currently modeled to handle analyses data from agricultural species, and will be expanded to include more species groups. Overall TransAtlasDB aims to serve as an accessible repository for the large complex results data files derived from RNAseq gene expression profiling and variant analysis. Database URL: https://modupeore.github.io/TransAtlasDB/ PMID:29688361

PBPK modeling of the cis- and trans-permethrin isomers and their major urinary metabolites in rats

Energy Technology Data Exchange (ETDEWEB)

Willemin, Marie-Emilie [Institut National de l' Environnement Industriel et des Risques (INERIS), Unité Modèles pour l' Ecotoxicologie et la Toxicologie (METO), Parc ALATA BP2, 60550, Verneuil en Halatte (France); Sorbonne University, Université de Technologie de Compiègne, CNRS, UMR 7338 Biomechanics and Bioengineering, Centre de recherche Royallieu CS 60319,60203 Compiègnee Cedex (France); Desmots, Sophie [Institut National de l' Environnement Industriel et des Risques (INERIS), Unité Toxicologie Expérimentale (TOXI), Parc ALATA BP2, 60550, Verneuil en Halatte (France); Le Grand, Rozenn [Centre Hospitalo-Universitaire de Limoges, Service de Pharmacologie et de Toxicologie — Pharmacovigilance, 2, avenue Martin Luther King, 87042 Limoges (France); Lestremau, François [Institut National de l' Environnement Industriel et des Risques (INERIS), Unité Innovation pour la Mesure (NOVA), Parc ALATA BP2, 60550, Verneuil en Halatte (France); Zeman, Florence A. [Institut National de l' Environnement Industriel et des Risques (INERIS), Unité Modèles pour l' Ecotoxicologie et la Toxicologie (METO), Parc ALATA BP2, 60550, Verneuil en Halatte (France); Leclerc, Eric [Sorbonne University, Université de Technologie de Compiègne, CNRS, UMR 7338 Biomechanics and Bioengineering, Centre de recherche Royallieu CS 60319,60203 Compiègnee Cedex (France); Moesch, Christian [Centre Hospitalo-Universitaire de Limoges, Service de Pharmacologie et de Toxicologie — Pharmacovigilance, 2, avenue Martin Luther King, 87042 Limoges (France); and others

2016-03-01

Permethrin, a pyrethroid insecticide, is suspected to induce neuronal and hormonal disturbances in humans. The widespread exposure of the populations has been confirmed by the detection of the urinary metabolites of permethrin in biomonitoring studies. Permethrin is a chiral molecule presenting two forms, the cis and the trans isomers. Because in vitro studies indicated a metabolic interaction between the trans and cis isomers of permethrin, we adapted and calibrated a PBPK model for trans- and cis-permethrin separately in rats. The model also describes the toxicokinetics of three urinary metabolites, cis- and trans-3-(2,2 dichlorovinyl)-2,2-dimethyl-(1-cyclopropane) carboxylic acid (cis- and trans-DCCA), 3-phenoxybenzoic acid (3-PBA) and 4′OH-phenoxybenzoic acid (4′-OH-PBA). In vivo experiments performed in Sprague–Dawley rats were used to calibrate the PBPK model in a Bayesian framework. The model captured well the toxicokinetics of permethrin isomers and their metabolites including the rapid absorption, the accumulation in fat, the extensive metabolism of the parent compounds, and the rapid elimination of metabolites in urine. Average hepatic clearances in rats were estimated to be 2.4 and 5.7 L/h/kg for cis- and trans-permethrin, respectively. High concentrations of the metabolite 4′-OH-PBA were measured in urine compared to cis- and trans-DCCA and 3-PBA. The confidence in the extended PBPK model was then confirmed by good predictions of published experimental data obtained using the isomers mixture. The extended PBPK model could be extrapolated to humans to predict the internal dose of exposure to permethrin from biomonitoring data in urine. - Highlights: • A PBPK model of isomers of permethrin and its urinary metabolites was developed. • A quantitative link was established for permethrin and its biomarkers of exposure. • The bayesian framework allows getting confidence interval on the estimated parameters. • The PBPK model can be extrapolated

PBPK modeling of the cis- and trans-permethrin isomers and their major urinary metabolites in rats

International Nuclear Information System (INIS)

Willemin, Marie-Emilie; Desmots, Sophie; Le Grand, Rozenn; Lestremau, François; Zeman, Florence A.; Leclerc, Eric; Moesch, Christian

2016-01-01

Permethrin, a pyrethroid insecticide, is suspected to induce neuronal and hormonal disturbances in humans. The widespread exposure of the populations has been confirmed by the detection of the urinary metabolites of permethrin in biomonitoring studies. Permethrin is a chiral molecule presenting two forms, the cis and the trans isomers. Because in vitro studies indicated a metabolic interaction between the trans and cis isomers of permethrin, we adapted and calibrated a PBPK model for trans- and cis-permethrin separately in rats. The model also describes the toxicokinetics of three urinary metabolites, cis- and trans-3-(2,2 dichlorovinyl)-2,2-dimethyl-(1-cyclopropane) carboxylic acid (cis- and trans-DCCA), 3-phenoxybenzoic acid (3-PBA) and 4′OH-phenoxybenzoic acid (4′-OH-PBA). In vivo experiments performed in Sprague–Dawley rats were used to calibrate the PBPK model in a Bayesian framework. The model captured well the toxicokinetics of permethrin isomers and their metabolites including the rapid absorption, the accumulation in fat, the extensive metabolism of the parent compounds, and the rapid elimination of metabolites in urine. Average hepatic clearances in rats were estimated to be 2.4 and 5.7 L/h/kg for cis- and trans-permethrin, respectively. High concentrations of the metabolite 4′-OH-PBA were measured in urine compared to cis- and trans-DCCA and 3-PBA. The confidence in the extended PBPK model was then confirmed by good predictions of published experimental data obtained using the isomers mixture. The extended PBPK model could be extrapolated to humans to predict the internal dose of exposure to permethrin from biomonitoring data in urine. - Highlights: • A PBPK model of isomers of permethrin and its urinary metabolites was developed. • A quantitative link was established for permethrin and its biomarkers of exposure. • The bayesian framework allows getting confidence interval on the estimated parameters. • The PBPK model can be extrapolated

An in vivo comparison of cis- and trans-[{sup 18}F]mefway in the nonhuman primate

Energy Technology Data Exchange (ETDEWEB)

Wooten, Dustin, E-mail: dwooten@wisc.edu [Department of Medical Physics, Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI 53705 (United States); Hillmer, Ansel; Murali, Dhanabalan; Barnhart, Todd [Department of Medical Physics, Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI 53705 (United States); Schneider, Mary L. [Department of Kinesiology, University of Wisconsin-Madison, Madison, WI 53706 (United States); Mukherjee, Jogeshwar [Preclinical Imaging Center, Department of Psychiatry and Human Behavior, University of California-Irvine, Irvine 92697 (United States); Christian, Bradley T. [Department of Medical Physics, Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI 53705 (United States)

2011-10-15

Introduction: [{sup 18}F]Mefway is a serotonin 5-HT{sub 1A} PET radiotracer with high specificity and favorable in vivo imaging properties. The chemical structure of [{sup 18}F]mefway permits {sup 18}F labeling in either the cis or trans positions at the 4-cyclohexyl site. We have previously reported on the in vivo kinetics of trans-[{sup 18}F]mefway in the nonhuman primate. In this work, we compare the in vivo binding of cis-[{sup 18}F]mefway and trans-[{sup 18}F]mefway to evaluate the properties of cis-[{sup 18}F]mefway for 5-HT{sub 1A} PET imaging. Methods: The cis- and trans-[{sup 18}F]mefway tracers were synthesized via nucleophilic substitution with their respective tosyl precursors. Two monkeys (one male, one female) were given bolus injections of both cis- and trans-labeled [{sup 18}F]mefway in separate experiments. Dynamic scans were acquired for 90 min with a microPET P4 scanner. Time-activity curves were extracted in the areas of the mesial temporal cortex (MTC), anterior cingulate gyrus (aCG), insular cortex (IC), raphe nuclei (RN) and cerebellum (CB). The in vivo behavior of the radiotracers was compared based upon the nondisplaceable binding potential (BP{sub ND}) using the CB as a reference region. Results: Averaged over the two subjects, BP{sub ND} values were as follows: MTC: 7.7, 0.58; aCG: 4.95, 0.32; IC: 3.27, 0.2; and RN: 3.05, 0.13, for trans-[{sup 18}F]mefway and cis-[{sup 18}F]mefway, respectively. Conclusion: The cis-labeled [{sup 18}F]mefway tracer has low specific binding throughout the 5-HT{sub 1A} regions of the brain compared to trans-[{sup 18}F]mefway, suggesting that the target-to-background binding of cis-[{sup 18}F]mefway may limit its use for in vivo assessment of 5-HT{sub 1A} binding.

Cis–Trans Configuration of Coumaric Acid Acylation Affects the Spectral and Colorimetric Properties of Anthocyanins

Directory of Open Access Journals (Sweden)

Gregory T. Sigurdson

2018-03-01

Full Text Available The color expression of anthocyanins can be affected by a variety of environmental factors and structural characteristics. Anthocyanin acylation (type and number of acids is known to be key, but the influence of acyl isomers (with unique stereochemistries remains to be explored. The objective of this study was to investigate the effects of cis–trans configuration of the acylating group on the spectral and colorimetric properties of anthocyanins. Petunidin-3-rutinoside-5-glucoside (Pt-3-rut-5-glu and Delphinidin-3-rutinoside-5-glucoside (Dp-3-rut-5-glu and their cis and trans coumaroylated derivatives were isolated from black goji and eggplant, diluted in pH 1–9 buffers, and analyzed spectrophotometrically (380–700 nm and colorimetrically (CIELAB during 72 h of storage (25 °C, dark. The stereochemistry of the acylating group strongly impacted the spectra, color, and stability of the Dp and Pt anthocyanins. Cis acylated pigments exhibited the greatest λmax in all pH, as much as 66 nm greater than their trans counterparts, showing bluer hues. Cis acylation seemed to reduce hydration across pH, increasing color intensity, while trans acylation generally improved color retention over time. Dp-3-cis-p-cou-rut-5-glu exhibited blue hues even in pH 5 (C*ab = 10, hab = 256° where anthocyanins are typically colorless. Cis or trans double bond configurations of the acylating group affected anthocyanin spectral and stability properties.

Potential energy profile, structural, vibrational and reactivity descriptors of trans-2-methoxycinnamic acid by FTIR, FT-Raman and quantum chemical studies

Science.gov (United States)

Arjunan, V.; Anitha, R.; Thenmozhi, S.; Marchewka, M. K.; Mohan, S.

2016-06-01

The stable conformers of trans-2-methoxycinnamic acid (trans-2MCA) are determined by potential energy profile analysis. The energies of the s-cis and s-trans conformers of trans-2MCA determined by B3LYP/cc-pVTZ method are -612.9788331 Hartrees and -612.9780953 Hartrees, respectively. The vibrational and electronic investigations of the stable s-cis and s-trans conformers of trans-2-methoxycinnamic acid have been carried out extensively with FTIR and FT-Raman spectral techniques. The s-cis conformer (I) with a (C16-C17-C18-O19) dihedral angle equal to 0° is found to be more favoured relative to the one s-trans (II) with (C16-C17-C18-O19) = 180°, possibly due to delocalization, hydrogen bonding and steric repulsion effects between the methoxy and acrylic acid groups. The DFT studies are performed with B3LYP method by utilizing 6-311++G** and cc-pVTZ basis sets to determine the structure, thermodynamic properties, vibrational characteristics and chemical shifts of the compound. The total dipole moments of the conformers determined by B3LYP/cc-pVTZ method are 3.35 D and 4.87 D for s-cis and s-trans, respectively. It reveals the higher polarity of s-trans conformer of trans-2MCA molecule. The electronic and steric influence of the methoxy group on the skeletal frequencies has been analysed. The energies of the frontier molecular orbitals and the LUMO-HOMO energy gap have been determined. The MEP of s-cis conformer lie in the range +1.374e × 10-2 to -1.374e × 10-2 while for s-trans it is +1.591e × 10-2 to -1.591e × 10-2. The total electron density of s-cis conformer lie in the range +5.273e × 10-2 to -5.273e × 10-2 while for s-trans it is +5.403e × 10-2 to -5.403e × 10-2. The MEP and total electron density shows that the s-cis conformer is less polar, less reactive and more stable than the s-trans conformer. All the reactivity descriptors of the molecule have been discussed. Intramolecular electronic interactions and their stabilisation energies have analysed

RevTrans: multiple alignment of coding DNA from aligned amino acid sequences

DEFF Research Database (Denmark)

Wernersson, Rasmus; Pedersen, Anders Gorm

2003-01-01

The simple fact that proteins are built from 20 amino acids while DNA only contains four different bases, means that the 'signal-to-noise ratio' in protein sequence alignments is much better than in alignments of DNA. Besides this information-theoretical advantage, protein alignments also benefit...... proteins. It is therefore preferable to align coding DNA at the amino acid level and it is for this purpose we have constructed the program RevTrans. RevTrans constructs a multiple DNA alignment by: (i) translating the DNA; (ii) aligning the resulting peptide sequences; and (iii) building a multiple DNA...

Intake of fatty acids in Western Europe with emphasis on trans fatty acids: The TRANSFAIR study

NARCIS (Netherlands)

Hulshof, K.F.A.M; Erp van - Baart, M.A.; Anttolainen, M.; Becker, W.; Church, S.M.; Couet, C.; Hermann-Kunz, E.; Kesteloot, H.; Leth, T.; Martins, I.; Moreiras, O.; Moschandreas, J.; Pizzoferrato, L.; Rimestad, A.H.; Thorgeirsdottir, H.; Amelsvoort, J.M.M. van; Aro, A.; Kafatos, A.G.; Lanzmann-Petithory, D.; Poppel, G. van

1999-01-01

Objective: To assess the intake of trans fatty acids (TFA) and other fatty acids in 14 Western European countries. Design and subjects: A maximum of 100 foods per country were sampled and centrally analysed. Each country calculated the intake of individual trans and other fatty acids, clusters of

Trans monounsaturated fatty acids and saturated fatty acids have similar effects on postprandial flow-mediated vasodilation

NARCIS (Netherlands)

Roos, de N.M.; Siebelink, E.; Bots, M.L.; Tol, van A.; Schouten, E.G.; Katan, M.B.

2002-01-01

Objective: Several studies suggest that a fatty meal impairs flow-mediated vasodilation (FMD), a measur9e of endothelial function. We tested whether the impairment was greater for trans fats than for saturated fats. We did this because we previously showed that replacement of saturated fats by trans

Intake of fatty acids in Western Europe with emphasis on trans fatty acids: The TRANSFAIR study

DEFF Research Database (Denmark)

Hulshof, K. F. A. M.; Erp-Baart, M. A. van; Anttolainen, M.

1999-01-01

Objective: To assess the intake of trans fatty acids (TFA) and other fatty acids in 14 Western European countries. Design and subjects: A maximum of 100 foods per country were sampled and centrally analysed. Each country calculated the intake of individual trans and other fatty acids, clusters of...

Change in trans fatty acid content of fast-food purchases associated with New York City's restaurant regulation: a pre-post study.

Science.gov (United States)

Angell, Sonia Y; Cobb, Laura K; Curtis, Christine J; Konty, Kevin J; Silver, Lynn D

2012-07-17

Dietary trans fat increases risk for coronary heart disease. In 2006, New York City (NYC) passed the first regulation in the United States restricting trans fat use in restaurants. To assess the effect of the NYC regulation on the trans and saturated fat content of fast-food purchases. Cross-sectional study that included purchase receipts matched to available nutritional information and brief surveys of adult lunchtime restaurant customers conducted in 2007 and 2009, before and after implementation of the regulation. 168 randomly selected NYC restaurant locations of 11 fast-food chains. Adult restaurant customers interviewed in 2007 and 2009. Change in mean grams of trans fat, saturated fat, trans plus saturated fat, and trans fat per 1000 kcal per purchase, overall and by chain type. The final sample included 6969 purchases in 2007 and 7885 purchases in 2009. Overall, mean trans fat per purchase decreased by 2.4 g (95% CI, -2.8 to -2.0 g; P restaurant was located was not associated with changes. Fast-food restaurants that were included may not be representative of all NYC restaurants. The introduction of a local restaurant regulation was associated with a substantial and statistically significant decrease in the trans fat content of purchases at fast-food chains, without a commensurate increase in saturated fat. Restaurant patrons from high- and low-poverty neighborhoods benefited equally. However, federal regulation will be necessary to fully eliminate population exposure to industrial trans fat sources. City of New York and the Robert Wood Johnson Foundation Healthy Eating Research program.

Preparation and characterization of trans-RhCl(CO)(TPPTS)2-intercalated layered double hydroxides

International Nuclear Information System (INIS)

Zhang Xian; Wei Min; Pu Min; Li Xianjun; Chen Hua; Evans, David G.; Duan Xue

2005-01-01

trans-RhCl(CO)(TPPTS) 2 (TPPTS=tris(m-sulfonatophenyl)phosphine) has been intercalated into Zn-Al layered double hydroxides (LDHs) by the method of ion exchange. The structure, composition and thermal stability of the composite material have been characterized by powder X-ray diffraction, Fourier transform infrared and 31 P solid-state magic-angle spinning nuclear magnetic resonance spectroscopy, elemental analysis, thermogravimetry, and differential thermal analysis. The geometry of trans-RhCl(CO)(TPPTS) 2 was fully optimized using the PM3 semiempirical molecular orbital method, and a schematic model for the intercalated species has been proposed. The thermal stability of trans-RhCl(CO)(TPPTS) 2 is significantly enhanced by intercalation, which suggests that such materials may have prospective application as the basis of a supported catalyst system for the hydroformylation of higher olefins

'Unladylike Commotion': Early feminism and nursing's role in gender/trans dialogue.

Science.gov (United States)

Fowler, Marsha D

2017-01-01

From nursing's history comes the impetus and grounding for our current voice in gender/trans dialogue. Modern nursing struggled its way into being against restrictive, unjust, and oppressive social structures. Many of the obstructions and constraints that nurses and nursing leaders faced were shared by the general populace of women, and yet nurses were different from other women. Nurses worked outside the home, caring for strangers, including unrelated men, in a period when women were otherwise confined to the home. Nurses fought for women's suffrage, for child labor laws, for the welfare of factory workers, for garment workers, for unionization, for vaccination, for housing reform, for the humane treatment of mentally ill persons, for access to birth control, for the amelioration of a panoramic terrain of terrible social injustices, and for the control of nursing education, registration, and practice. For 150 years, nursing has been intrinsically, practically, and politically feminist. The hard-fought gains would eventually position nursing in tension with emerging trans issues. And yet, its history is exactly what situates nursing for fruitful participation in the developing trans discourse and to address issues of transinvisibility and unjust social and health structures that impede dignified and respectful health care. © 2017 John Wiley & Sons Ltd.

Effect of Extruding Full-Fat Soy Flakes on Trans Fat Content

Directory of Open Access Journals (Sweden)

Hongxia Feng

2014-01-01

Full Text Available To evaluate the effects of extrusion process on the trans fatty acids (TFAs formation in soybean crude oils, three different extrusion parameters, namely, extrusion temperature (80–160°C, feed moisture (10–26%, and screw speed (100–500 rpm, were carried out. It was found that only five different types of TFAs were detected out using gas chromatography-mass spectrometry. Before the extrusion started, the initial amount of total TFAs was 3.04 g/100 g. However, after extruding under every level of any variable, the total amounts of TFAs were significantly higher than those in the control sample (P<0.05. For example, taking the effect of extrusion temperature into account, we can find that the highest amount of total of trans fatty acid (TTFA was 1.62 times the amount of that in the control sample, whereas the lowest amount of TTFA was 1.54 times the amount of that in the control sample. Importantly, it was observed that the amounts of every type of trans fatty acid were not continuously increasing with the increase of the level of any extrusion variable. This phenomenon demonstrated that the formation and diversification were intricate during extruding process and need to be further studied.

Trans-esterification of poultry skin fat to produce biodiesel

International Nuclear Information System (INIS)

Anees, H.; Shah, S.F.A.; Ali, Z.M.

2016-01-01

Chicken skin and its fat are sources of solid waste that are usually not utilized and add solid pollution. This research work deals with the production of useful biodiesel from utilizing the waste chicken (fat and its skins). Waste chicken fat and its skins (sourced from local shops of Hyderabad, Sindh, Pakistan) were extracted and trans-estrification was made. The product of trans-estrification was fatty acid methyl esters (FAME) commonly known as biodiesel. Sodium Hydroxide (NaOH) was used as catalyst and glycerol was obtained as a by-product. The FAME produced was tested for six parameters namely calorific value, cloud point, pour point, flash point, density and viscosity when compared to ASTM E2515-11 standard values. The results of this experiment showed that the calorific value, cloud point, pour point, flash point, density and viscosity values of FAME produced from chicken skin and its fat were close to that of petroleum derived diesel. (author)

Extended SVM algorithms for multilevel trans-Z-source inverter

Directory of Open Access Journals (Sweden)

Aida Baghbany Oskouei

2016-03-01

Full Text Available This paper suggests extended algorithms for multilevel trans-Z-source inverter. These algorithms are based on space vector modulation (SVM, which works with high switching frequency and does not generate the mean value of the desired load voltage in every switching interval. In this topology the output voltage is not limited to dc voltage source similar to traditional cascaded multilevel inverter and can be increased with trans-Z-network shoot-through state control. Besides, it is more reliable against short circuit, and due to several number of dc sources in each phase of this topology, it is possible to use it in hybrid renewable energy. Proposed SVM algorithms include the following: Combined modulation algorithm (SVPWM and shoot-through implementation in dwell times of voltage vectors algorithm. These algorithms are compared from viewpoint of simplicity, accuracy, number of switching, and THD. Simulation and experimental results are presented to demonstrate the expected representations.

Synthesis and crystal structure of trans-[Ni(pyzdcH)M 2 (H 2 O) 2 ...

African Journals Online (AJOL)

The determined structure of the title compound C24H20Ni2N8O20 consists of the mononuclear trans-[Ni(pyzdc)2(H2O)2], (pyzdc = pyrazine-2,3- dicarboxylate). The Ni(II) atom is hexa-coordinated by two (pyzdcH)- groups and two water molecules. The coordinated water molecules are in trans-diaxial positions and the ...

Expression of Herpes Simplex Virus Thymidine Kinase/Ganciclovir by RNA Trans-Splicing Induces Selective Killing of HIV-Producing Cells

Directory of Open Access Journals (Sweden)

Carin K. Ingemarsdotter

2017-06-01

Full Text Available Antiviral strategies targeting hijacked cellular processes are less easily evaded by the virus than viral targets. If selective for viral functions, they can have a high therapeutic index. We used RNA trans-splicing to deliver the herpes simplex virus thymidine kinase-ganciclovir (HSV-tk/GCV cell suicide system into HIV-producing cells. Using an extensive in silico bioinformatics and RNA structural analysis approach, ten HIV RNA trans-splicing constructs were designed targeting eight different HIV splice donor or acceptor sites and were tested in cells expressing HIV. Trans-spliced mRNAs were identified in HIV-expressing cells using qRT-PCR with successful detection of fusion RNA transcripts between HIV RNA and the HSV-tk RNA transcripts from six of ten candidate RNA trans-splicing constructs. Conventional PCR and Sanger sequencing confirmed RNA trans-splicing junctions. Measuring cell viability in the presence or absence of GCV expression of HSV-tk by RNA trans-splicing led to selective killing of HIV-producing cells using either 3′ exon replacement or 5′ exon replacement in the presence of GCV. Five constructs targeting four HIV splice donor and acceptor sites, D4, A5, A7, and A8, involved in regulating the generation of multiple HIV RNA transcripts proved to be effective for trans-splicing mediated selective killing of HIV-infected cells, within which individual constructs targeting D4 and A8 were the most efficient.

Modeling and Compensation Design for a Power Hardware-in-the-Loop Simulation of an AC Distribution System: Preprint

Energy Technology Data Exchange (ETDEWEB)

Prabakar, Kumaraguru [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Ainsworth, Nathan [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Pratt, Annabelle [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Baggu, Murali M [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Hariri, Ali [Formerly NREL

2017-10-06

Power hardware-in-the-loop (PHIL) simulation, where actual hardware under text is coupled with a real-time digital model in closed loop, is a powerful tool for analyzing new methods of control for emerging distributed power systems. However, without careful design and compensation of the interface between the simulated and actual systems, PHIL simulations may exhibit instability and modeling inaccuracies. This paper addresses issues that arise in the PHIL simulation of a hardware battery inverter interfaced with a simulated distribution feeder. Both the stability and accuracy issues are modeled and characterized, and a methodology for design of PHIL interface compensation to ensure stability and accuracy is presented. The stability and accuracy of the resulting compensated PHIL simulation is then shown by experiment.

Trans-pterostilbene and its derivative 2,4-dimethoxy-6 -hydroxyphenanthrene in the leaves of Parthenocissus tricuspidata

Czech Academy of Sciences Publication Activity Database

Vrchotová, Naděžda; Tříska, Jan

2017-01-01

Roč. 7, č. 2 (2017), s. 146-148 ISSN 1805-0174 R&D Projects: GA MŠk(CZ) LO1415 Institutional support: RVO:86652079 Keywords : resveratrol dimer * antioxidant * Parthenocissus tricuspidata * trans-pterostilbene * 2,4-dimethoxy-6-hydroxyphenanthrene * trans-resveratrol Subject RIV: EH - Ecology, Behaviour OBOR OECD: Biochemistry and molecular biology

TRAN-STAT: statistics for environmental studies

International Nuclear Information System (INIS)

Gilbert, R.O.

1984-09-01

This issue of TRAN-STAT discusses statistical methods for assessing the uncertainty in predictions of pollutant transport models, particularly for radionuclides. Emphasis is placed on radionuclide transport models but the statistical assessment techniques also apply in general to other types of pollutants. The report begins with an outline of why an assessment of prediction uncertainties is important. This is followed by an introduction to several methods currently used in these assessments. This in turn is followed by more detailed discussion of the methods, including examples. 43 references, 2 figures

Pengaruh Kualitas Pelayanan Dan Nilai Pelanggan Terhadap Kepuasan Dan Loyalitas Pelanggan Trans Metro Pekanbaru

OpenAIRE

Harpadeles, Ian; ', Jushermi; Nursanti, Aida

2016-01-01

This study aims to measure the impact of service quality and customer value on customer satisfaction and loyalty Trans Metro Pekanbaru. The population in this study is the Trans Metro Pekanbaru customers with a total sample of 100 respondents, using purposive sampling technique. Analysis of data using path analysis with SPSS version 17.0. The results showed that the variables of service quality significantly influence customer satisfaction. Customer value significantly influence customer sati...

Trans-European transport networks influence on the regional development and urban systems: Serbian experience

OpenAIRE

Maksin-Mićić Marija

2004-01-01

The trans-European transport network has different effects at macro-regional, mezzo-regional and micro-regional level, and on urban systems development, and its effectiveness rises at the lower regional levels. Possible approaches to the trans-European transport network impact and effect survey and policy options have been pointed out. The importance of increased accessibility and mobility for regional expansion and for more balanced and polycentric system of city networks has been underlined...

The effects of callus age, UV irradiation and incubation time on trans-resveratol production in grapevine callus culture

International Nuclear Information System (INIS)

Keskin, N.; Kunter, B.

2009-01-01

In this study, the effects of callus age, ultraviolet (UV) irradiation and incubation time were investigated for the induction of trans-resveratrol production in callus cultures of Kalecik karası (Clone 12) Vitis vinifera L. grape cultivar. Part of leaves (~1 cm 2 ) were taken from one year old grapevines grown in greenhouse and then were cultured in Gamborg B-5 media including 2% saccarose, 0.8% agar, 1.0 μM BAP (6-benzylaminopurine) and 0.1 μM 2, 4-D (2, 4-dichlorophenoxy-acetic acid). After the second subculture, 12 and 15 days old callus tissues were exposed to 254 nm UV light at 10 cm distance from the source for 10 and 15 min. Trans-resveratrol was measured at 0, 24, 48 and 72 hours of incubation by using High Pressure Liquid Chromatography (HPLC). Trans-resveratrol concentration of control callus ranged from 0.56 to 0.96 μg g fw -1 . The highest trans-resveratrol production was obtained from 12 and 15 days-old callus irradiated for 10 min. at the 48th hours of incubation (2.42 μg g fw -1 ). Considering the highest value of trans-resveratrol concentration in controls and experiments, it was determined that UV irraditation in Kalecik karası elicitated the trans-resveratrol production by 2.5 times. (author) [tr

Reactivity toward alcohols of (Ru/sup IV/ = O/sup 2-/) unit in trans-(RuCl(O)(py)/sub 4/)/sup +/

Energy Technology Data Exchange (ETDEWEB)

Aoyagi, Kimitake; Nagao, Hirotaka; Yukawa, Yasuhiko; Ogura, Mariko; Kuwayama, Akito; Howell, F S; Mukaida, Masao; Kakihana, Hidetake

1986-12-01

The reactivity with alcohol of trans-(RuCl(O)(py)/sub 4/)/sup +/ was investigated. In MeOH, trans-(RuCl(OH)(py)/sub 4/)/sup +/ was confirmed to exist as a precursor in the formation of trans-(RuCl(OMe)(py)/sub 4/)/sup +/. The reaction progress was traced by spectrometrical and /sup 18/O-labelling experiments.

Abscisic (ABA)-aldehyde is a precursor to, and 1',4'-trans-ABA-diol a catabolite of, ABA in apple

International Nuclear Information System (INIS)

Rock, C.D.; Zeevaart, J.A.D.

1990-01-01

Previous 18 O labeling studies of abscisic acid (ABA) have shown that apple (Malus domestica Borkh. cv Granny Smith) fruits synthesize a majority of [ 18 O]ABA with the label incorporated in the 1'-hydroxyl position and unlabeled in the carboxyl group (JAD Zeevaart, TG Heath, DA Gage [1989] Plant Physiol 91: 1594-1601). It was proposed that exchange of 18 O in the side chain with the medium occurred at an aldehyde intermediate stage of ABA biosynthesis. We have isolated ABA-aldehyde and 1'-4'-trans-ABA-diol (ABA-trans-diol) from 18 O-labeled apple fruit tissue and measured the extent and position of 18 O incorporation by tandem mass spectrometry. 18 O-Labeling patterns of ABA-aldehyde, ABA-trans-diol, and ABA indicate that ABA-aldehyde is a precursor to, and ABA-trans-diol a catabolite of, ABA. Exchange of 18 O in the carbonyl of ABA-aldehyde can be the cause of loss of 18 O from the side chain of [ 18 O]ABA. Results of feeding experiments with deuterated substrates provide further support for the precursor-product relationship of ABA-aldehyde → ABA → ABA-trans-diol. The ABA-aldehyde and ABA-trans-diol contents of fruits and leaves were low, approximately 1 and 0.02 nanograms per gram fresh weight for ABA-aldehyde and ABA-trans-diol, respectively, while ABA levels in fruits ranged from 10 to 200 nanograms per gram fresh weight. ABA biosynthesis was about 10-fold lower in fruits than in leaves. In fruits, the majority of ABA was conjugated to β-D-glucopyranosyl abscisate, whereas in leaves ABA was mainly hydroxylated to phaseic acid. Parallel pathways for ABA and trans-ABA biosynthesis and conjugation in fruits and leaves are proposed

Exploring the Trans-Neptunian Solar System

Science.gov (United States)

1998-01-01

A profound question for scientists, philosophers and, indeed, all humans concerns how the solar system originated and subsequently evolved. To understand the solar system's formation, it is necessary to document fully the chemical and physical makeup of its components today, particularly those parts thought to retain clues about primordial conditions and processes.] In the past decade, our knowledge of the outermost, or trans-neptunian, region of the solar system has been transformed as a result of Earth-based observations of the Pluto-Charon system, Voyager 2's encounter with Neptune and its satellite Triton, and recent discoveries of dozens of bodies near to or beyond the orbit of Neptune. As a class, these newly detected objects, along with Pluto, Charon, and Triton, occupy the inner region of a hitherto unexplored component of the solar system, the Kuiper Belt. The Kuiper Belt is believed to be a reservoir of primordial objects of the type that formed in the solar nebula and eventually accreted to form the major planets. The Kuiper Belt is also thought to be the source of short-period comets and a population of icy bodies, the Centaurs, with orbits among the giant planets. Additional components of the distant outer solar system, such as dust and the Oort comet cloud, as well as the planet Neptune itself, are not discussed in this report. Our increasing knowledge of the trans-neptunian solar system has been matched by a corresponding increase in our capabilities for remote and in situ observation of these distant regions. Over the next 10 to 15 years, a new generation of ground- and space-based instruments, including the Keck and Gemini telescopes and the Space Infrared Telescope Facility, will greatly expand our ability to search for and conduct physical and chemical studies on these distant bodies. Over the same time span, a new generation of lightweight spacecraft should become available and enable the first missions designed specifically to explore the icy

'It was like I had to fit into a category': Care-seekers' experiences of gender regulation in the Swedish trans-specific healthcare.

Science.gov (United States)

Linander, Ida; Alm, Erika; Goicolea, Isabel; Harryson, Lisa

2017-05-01

The few previous studies investigating regulation of gender in trans-specific healthcare are mainly based on text material and interviews with care-providers or consist solely of theoretical analyses. There is a lack of studies analysing how the regulation of gender is expressed in the care-seeker's own experiences, especially in a Nordic context. The aim of this study is to analyse narratives of individuals with trans experiences (sometimes called transgender people) to examine how gender performances can be regulated in trans-specific care in Sweden. The conceptual framework is inspired by trans studies, a Foucauldian analysis of power, queer phenomenology and the concept of cisnormativity. Fourteen interviews with people with trans experiences are analysed with constructivist grounded theory. The participants' experiences indicate that gender is constructed as norm-conforming, binary and stable in trans-specific healthcare. This gendered position is resisted, negotiated and embraced by the care-seekers. Norms and discourses both inside and outside trans-specific care contribute to the regulation and limit the room for action for care-users. We conclude that a trans-specific care that has a confirming approach to its care-users, instead of the current focus on gender norm conformity, has the potential to increase the self-determination of gender performance and increase the quality of care.

The initial experience of trans-rectal ultrasound and biopsy in ...

African Journals Online (AJOL)

The initial experience of trans-rectal ultrasound and biopsy in diagnosis of carcinoma prostate in Gezira Hospital for Renal Disease and Surgery (GHRDS). Walaa Eldin Ibraheem, Sami Mahjoub Taha, Mustafa Omran Mansour, Mohammed El Imam Mohamed Ahmed ...

Synthesis, characterization and evaluation of uniformly sized core-shell imprinted microspheres for the separation trans-resveratrol from giant knotweed

International Nuclear Information System (INIS)

Zhang Zhaohui; Liu Li; Li Hui; Yao Shouzhuo

2009-01-01

A novel core-shell molecularly imprinting microspheres (MIMs) with trans-resveratrol as the template molecule; acrylamide (AA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as cross-linker, was prepared based on SiO 2 microspheres with surface imprinting technique. These core-shell trans-resveratrol imprinted microspheres were characterized by infrared spectra (IR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and high performance liquid chromatography (HPLC). The results showed that these core-shell imprinted microspheres, which take on perfect spherical shape with average shell thickness of 150 nm, exhibit especially selective recognition for trans-resveratrol. These imprinted microspheres were applied as solid-phase extraction materials for selective extraction of trans-resveratrol from giant knotweed extracting solution successfully.

Synthesis, characterization and evaluation of uniformly sized core-shell imprinted microspheres for the separation trans-resveratrol from giant knotweed

Energy Technology Data Exchange (ETDEWEB)

Zhang Zhaohui, E-mail: zhaohuizhang77@hotmail.com [College of Chemistry and Chemical Engineering, Jishou University, Jishou, 416000 (China); State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, 410082 (China); Liu Li; Li Hui [College of Chemistry and Chemical Engineering, Jishou University, Jishou, 416000 (China); Yao Shouzhuo [State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, 410082 (China)

2009-09-15

A novel core-shell molecularly imprinting microspheres (MIMs) with trans-resveratrol as the template molecule; acrylamide (AA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as cross-linker, was prepared based on SiO{sub 2} microspheres with surface imprinting technique. These core-shell trans-resveratrol imprinted microspheres were characterized by infrared spectra (IR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and high performance liquid chromatography (HPLC). The results showed that these core-shell imprinted microspheres, which take on perfect spherical shape with average shell thickness of 150 nm, exhibit especially selective recognition for trans-resveratrol. These imprinted microspheres were applied as solid-phase extraction materials for selective extraction of trans-resveratrol from giant knotweed extracting solution successfully.

Meteoritic Evidence for Injection of Trans-Neptunian Objects into the Inner Solar System

Science.gov (United States)

Zolensky, M.; Johnson, J.; Ziegler, K.; Chan, Q.; Kebukawa, Y.; Bottke, W.; Fries, M.; Martinez, J.; Le, L.

2018-01-01

There is excellent evidence that a dynamical instability in the early solar system led to gravitational interactions between the giant planets and trans-Neptunian planetesimals. Giant planetary migration triggered by the instability dispersed a disk of primordial trans-Neptunian object (TNOs) and created a number of small body reservoirs (e.g. the Kuiper Belt, scattered disk, irregular satellites, and the Jupiter/Neptune Trojan populations). It also injected numerous bodies into the main asteroid belt, where modeling shows they can successfully reproduce the observed P and D-type asteroid populations.

The Studsvik power transient programs Demo-Ramp II and Trans-Ramp I

International Nuclear Information System (INIS)

Bergenlid, U.; Lysell, G.; Mogard, H.; Roennberg, G.

1984-01-01

The Studsvik Demo-Ramp II och Trans-Ramp I are internationally sponsored research programs. The main objectives are similar in both programs: to study the effects on the PCI/SCC failure process of short time power transients, above the failure threshold where cladding failure (FP leakage) is expected to occur after a sufficient hold time. Demo-Ramp II is completed, whereas, at present, Trans-Ramp I is in progress. Test fuel rods of standard BWR design are used. The fuel rods have been base-irradiated in a power reactor (burn-up in the range 18 to 29 MWd/kg U) and subsequently ramp tested in the R2 reactor. Extensive examinations of the rods have been performed. In the Demo-Ramp II program a large number of incipient cladding cracks were observed to be formed more rapidly than expected, based on previous knowledge. It was possible to operate one rod for a very short time above the failure threshold without SCC crack formation. One objective of the Trans-Ramp I program is to define more closely the power-time region above the failure threshold where the rods remain intact after power transients. (author)

The analgesic effect of trans-resveratrol is regulated by calcium channels in the hippocampus of mice.

Science.gov (United States)

Wang, Weijie; Yu, Yingcong; Li, Jing; Wang, Lin; Li, Zhi; Zhang, Chong; Zhen, Linlin; Ding, Lianshu; Wang, Gang; Sun, Xiaoyang; Xu, Ying

2017-08-01

Resveratrol has been widely studied in terms of it's potential to slow the progression of many diseases. But little is known about the mechanism of action in neuropathic pain. Neuropathic pain is the main type of chronic pain associated with tissue injury. Calcium channels and calcium/caffeine-sensitive pools are associated with analgesic pathway involving neuropathic pain. Our previous study suggested that the antinociceptive effect of resveratrol was involved in Ca 2+ /calmodulin-dependent signaling in the spinal cord of mice. The aim of this study was to explore the involvement of Ca 2+ in analgesic effects of trans-resveratrol in neuropathic pain and signal pathway in hippocampus. Hot plate test was used to assess antinociceptive response when mice were treated with trans-resveratrol alone or in combination with Mk 801, nimodipine, CaCl 2 , ryanodine or EGTA. The effects of trans-resveratrol and the combination on Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) and BDNF (brain-derived neurotrophic factor) expression in hippocampus were also investigated. The results showed that trans-resveratrol increased paw withdraw latency in the hot plate test. The effect of resveratrol was enhanced by Mk 801 and nimodipine. Central administration of Ca 2+ , however, abolished the antinociceptive effects of resveratrol. In contrast, centrally administered EGTA or ryanodine improved trans-resveratrol induced antinociception. There was a significant increase in p-CaMKII and BDNF expression in the hippocampus when resveratrol were combined with Mk 801, nimodipine, ryanodine and EGTA. Administration of CaCl 2 blocked changes in p-CaMKII and BDNF levels in the hippocampus. These findings suggest that trans-resveratrol exerts the effects of antinociception through regulation of calcium channels and calcium/caffeine-sensitive pools.

tRNA Is the Source of Low-Level trans-Zeatin Production in Methylobacterium spp.†‡

Science.gov (United States)

Koenig, Robbin L.; Morris, Roy O.; Polacco, Joe C.

2002-01-01

Pink-pigmented facultatively methylotrophic bacteria (PPFMs), classified as Methylobacterium spp., are persistent colonizers of plant leaf surfaces. Reports of PPFM-plant dialogue led us to examine cytokinin production by PPFMs. Using immunoaffinity and high-performance liquid chromatography (HPLC) purification, we obtained 22 to 111 ng of trans-zeatin per liter from culture filtrates of four PPFM leaf isolates (from Arabidopsis, barley, maize, and soybean) and of a Methylobacterium extorquens type culture originally recovered as a soil isolate. We identified the zeatin isolated as the trans isomer by HPLC and by a radioimmunoassay in which monoclonal antibodies specific for trans-hydroxylated cytokinins were used. Smaller and variable amounts of trans-zeatin riboside were also recovered. trans-Zeatin was recovered from tRNA hydrolysates in addition to the culture filtrates, suggesting that secreted trans-zeatin resulted from tRNA turnover rather than from de novo synthesis. The product of the miaA gene is responsible for isopentenylation of a specific adenine in some tRNAs. To confirm that the secreted zeatin originated from tRNA, we mutated the miaA gene of M. extorquens by single exchange of an internal miaA fragment into the chromosomal gene. Mutant exconjugants, confirmed by PCR, did not contain zeatin in their tRNAs and did not secrete zeatin into the medium, findings which are consistent with the hypothesis that all zeatin is tRNA derived rather than synthesized de novo. In germination studies performed with heat-treated soybean seeds, cytokinin-null (miaA) mutants stimulated germination as well as wild-type bacteria. While cytokinin production may play a role in the plant-PPFM interaction, it is not responsible for stimulation of germination by PPFMs. PMID:11889088

The synthesis and preliminary pharmacological evaluation of the racemic cis and trans 3-alkylfentanyl analogues

Directory of Open Access Journals (Sweden)

LJ. DOSEN-MICOVIC

2004-07-01

Full Text Available A general, five step method for the synthesis of 3-alkylfentanyl analogues (i.e., cis and trans 3-alkyl-4-anilidopiperidines 6.1–6.6 has been developed. The starting N-phenethyl-4-piperidone 1 was first converted into the cyclohexylimine derivative 2, a-deprotonated with butyllithium and the resulting imine anion efficiently monoalkylated with primary and secondary alkyl halides. After mild acid hydrolysis, the obtained 3-alkyl-4-piperidones 3.1–3.6 were isolated in good yields (79–85 %, then condensed with aniline to form imines 4.1–4.6. Subsequent reduction of the imines (LiAlH4/THF yielded cis/trans mixtures of 3-alkyl-4-anilinopiperidines 5.1–5.6. Quantitative separation of the diastereoisomers by column chromatography of Al2O3 gave pure cis 5.1–5.6 (29–51 % yield and trans 5.1–5.6 (19–27 % yield, with the cis/trans ratio in the range 7/3–6/4. The synthesis was concluded by N-acylation of the purified 5.1–5.6, with propionyl chloride, to afford cis and trans 3-alkyl-4-anilidopiperidines 6.1–6.6 (~95 % yield, as monooxalate salts. No enatioseparation was attempted at any stage. The relative cis/trans stereochemistry was provisionally assigned from the 1H-NMR spectra. Of the twelve synthesized 3-alkylfentanyls, ten compounds (two known and eight novel derivatives, all as the monooxalate salts were preliminarily tested as analgesics in rats, comparing the potency to fentanyl. Except for the known (±-cis-3-Me fentanyl 6.1cis, (8 × fentanyl, and the novel (±-cis-3-Et fentanyl 6.2cis, (1.5 × fentanyl, all of the others were less active than fentanyl or inactive. Some tentative conclusions on the structure-activity relationship (SAR in this series of derivatives have been made.

Trans-oral robotic surgery in oropharyngeal carcinoma - A guide for general practitioners and patients.

Science.gov (United States)

Liu, Wendy Sijia; Limmer, Alex; Jabbour, Joe; Clark, Jonathan

Trans-oral robotic surgery (TORS) is emerging as a minimally invasive alternative to open surgery, or trans-oral laser surgery, for the treatment of some head and neck pathologies, particularly oropharyngeal carcinoma, which is rapidly increasing in incidence. In this article we review current evidence regarding the use of TORS in head and neck surgery in a manner relevant to general practice. This information may be used to facilitate discussion with patients. Compared with open surgery or trans-oral laser surgery, TORS has numerous advantages, including no scarring, less blood loss, fewer complications, lower rates of admission to the intensive care unit, and reduced length of hospitalisation. The availability of TORS in Australia is currently limited and, therefore, public awareness about TORS is lacking. Details regarding the role of TORS and reliable, up-to-date, patient-friendly information sources are discussed in this article.

Relic gravitational wave spectrum, the trans-Planckian physics and Horava-Lifshitz gravity

International Nuclear Information System (INIS)

Koh, Seoktae

2010-01-01

We calculate the spectrum of the relic gravitational wave due to the trans-Planckian effect in which the standard linear dispersion relations may be modified. Of the modified dispersion relations suggested in the literature which has investigated the trans-Planckian effect, we especially use the Corley-Jacobson dispersion relations. The Corley-Jacobson-type modified dispersion relations can be obtained from Horava-Lifshitz gravity which is non-relativistic and UV complete. Although it is not clear how the transitions from Horava-Lifshitz gravity in the UV regime to Einstein gravity in the IR limit occur, we assume that the Horava-Lifshitz gravity regime is followed by the inflationary phase in Einstein gravity.

Distributional congruence of mammalian herbivores in the Trans-Himalayan Mountains

NARCIS (Netherlands)

Namgail, T.; Wieren, van S.E.; Prins, H.H.T.

2013-01-01

Large-scale distribution and diversity patterns of mammalian herbivores, especially less charismatic species in alpine environments remain little understood. We studied distributional congruence of mammalian herbivores in the Trans-Himalayan region of Ladakh to see if the distributions of less

Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects.

Science.gov (United States)

la Porte, Charles; Voduc, Nha; Zhang, Guijun; Seguin, Isabelle; Tardiff, Danielle; Singhal, Neera; Cameron, D William

2010-07-01

Trans-resveratrol is a polyphenol, which is found in red wine and has cancer chemo-preventive properties and disease-preventive properties. The pharmacokinetics of trans-resveratrol have been investigated in single-dose studies and in studies with relatively low dosages. The present study aimed to investigate the steady-state pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol). This was a two-period, open-label, single-arm, within-subject control study in eight healthy subjects. The steady-state 12-hour pharmacokinetics of trans-resveratrol 2000 mg twice daily were studied with a standard breakfast, a high-fat breakfast, quercetin 500 mg twice daily and 5% alcohol 100 mL. Trans-resveratrol plasma concentrations were determined using liquid chromatography with tandem mass spectrometry. The mean (SD) area under the plasma concentration-time curve from 0 to 12 hours (AUC(12)) and maximum plasma concentration (C(max)) of trans-resveratrol were 3558 (2195) ng * h/mL and 1274 (790) ng/mL, respectively, after the standard breakfast. The high-fat breakfast significantly decreased the AUC(12) and C(max) by 45% and 46%, respectively, when compared with the standard breakfast. Quercetin 500 mg twice daily or 5% alcohol 100 mL did not influence trans-resveratrol pharmacokinetics. Diarrhoea was reported in six of the eight subjects. Significant but not clinically relevant changes from baseline were observed in serum potassium and total bilirubin levels. Trans-resveratrol 2000 mg twice daily resulted in adequate exposure and was well tolerated by healthy subjects, although diarrhoea was frequently observed. In order to maximize trans-resveratrol exposure, it should be taken with a standard breakfast and not with a high-fat meal. Furthermore, combined intake with quercetin or alcohol did not influence trans-resveratrol exposure.

Excited State s-cis Rotamers Produced by Extreme Red Edge Excitation of all-trans-1,4-Diphenyl-1,3-butadiene

DEFF Research Database (Denmark)

Wallace-Williams, Stacie E.; Møller, Søren; Goldbeck, Robert A.

1993-01-01

with the wavelength independence observed for the excited singlet-state absorption and fluorescence emission spectra of 1,5-diphenyl-2,3,4,6,7,8- hexahydronaphthalene and for the fluorescence emission spectra of 1,4diphenyl-1,3-cyclopentadiene, s-trans and s-cis structural analogs of DPB, respectively. The spectral...... changes in DPB can be explained in terms of an excitation wavelength-dependent production of s-cis and s-trans rotamer populations in the excited state. The DPB fluorescence emission spectrum was resolved into s-cis and s-trans components. The vibronic structure of the s-cis fluorescence spectrum...... is similar to that of s-trans, but the band origin is red-shifted and there is a slightly larger amplitude on the red edge. The excited-state absorption spectrum of s-cis DPB appears to be red-shifted relative to that of s-trans DPB as well....

Enzymatic and free radical formation of cis- and trans- epoxyeicosatrienoic acids in vitro and in vivo.

Science.gov (United States)

Aliwarga, Theresa; Raccor, Brianne S; Lemaitre, Rozenn N; Sotoodehnia, Nona; Gharib, Sina A; Xu, Libin; Totah, Rheem A

2017-11-01

Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid (AA) oxidation that have important cardioprotective and signaling properties. AA is an ω-6 polyunsaturated fatty acid (PUFA) that is prone to autoxidation. Although hydroperoxides and isoprostanes are major autoxidation products of AA, EETs are also formed from the largely overlooked peroxyl radical addition mechanism. While autoxidation yields both cis- and trans-EETs, cytochrome P450 (CYP) epoxygenases have been shown to exclusively catalyze the formation of all regioisomer cis-EETs, on each of the double bonds. In plasma and red blood cell (RBC) membranes, cis- and trans-EETs have been observed, and both have multiple physiological functions. We developed a sensitive ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) assay that separates cis- and trans- isomers of EETs and applied it to determine the relative distribution of cis- vs. trans-EETs in reaction mixtures of AA subjected to free radical oxidation in benzene and liposomes in vitro. We also determined the in vivo distribution of EETs in several tissues, including human and mouse heart, and RBC membranes. We then measured EET levels in heart and RBC of young mice compared to old. Formation of EETs in free radical reactions of AA in benzene and in liposomes exhibited time- and AA concentration-dependent increase and trans-EET levels were higher than cis-EETs under both conditions. In contrast, cis-EET levels were overall higher in biological samples. In general, trans-EETs increased with mouse age more than cis-EETs. We propose a mechanism for the non-enzymatic formation of cis- and trans-EETs involving addition of the peroxyl radical to one of AA's double bonds followed by bond rotation and intramolecular homolytic substitution (S H i). Enzymatic formation of cis-EETs by cytochrome P450 most likely occurs via a one-step concerted mechanism that does not allow bond rotation. The ability to accurately measure

Can we conserve trans-resveratrol content and antioxidant activity during industrial production of chocolate?

Science.gov (United States)

Salvador, Izabela; Massarioli, Adna P; Silva, Anna Paula S; Malaguetta, Heloísa; Melo, Priscilla S; Alencar, Severino M

2018-05-23

Cocoa exhibits high content of phenolic compounds, among which trans-resveratrol stands out, associated with several bioactive activities such as antioxidant properties. Chocolate contains reduced amounts of these bioactive compounds due to losses during the production process. Therefore, this study aimed to assess changes in total phenolic content and specifically trans-resveratrol, as well as in the antioxidant activity of cocoa and its products during industrial production of chocolate. A total of ten different cocoa products were analyzed. The processes of fermentation and roasting caused significant loss of total phenolic compounds and antioxidant activity. However, due to high temperature, roasting had a major influence on this loss (71% for total phenolic compounds and 53% to 77% for antioxidant activity), except for trans-resveratrol. The content of trans-resveratrol formed after fermentation (9.8 μg kg -1 ) showed little variation during the processes, and it was detected in higher concentrations both in natural (11.4 μg kg -1 ) and in alkalized cocoa powder (13.5 μg kg -1 ). Alkalization of cocoa products led to loss of capacity of deactivating superoxide radical. These findings contribute to the optimization of the production process of chocolate and other food products containing cocoa and its derivatives aiming to better preserve their bioactive compounds. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Aplicação de gorduras "low trans" à base de soja, formuladas utilizando rede neural artificial, em biscoitos laminados

OpenAIRE

Alessandra Afonso Teixeira Penteado

2012-01-01

Resumo: Após as crescentes divulgações na mídia dos malefícios à saúde causados pela ingestão de gorduras trans e a Resolução RDC 360, de 23 de dezembro de 2003, que estabelece a obrigatoriedade de declaração dos níveis de gordura trans nos rótulos dos alimentos industrializados, nota-se uma crescente demanda por produtos sem ácidos graxos trans (¿low trans¿). O objetivo principal deste projeto foi aplicar a tecnologia de Redes Neurais Artificiais (RNAs) para a obtenção de blends de gorduras ...

Trans and cis influences and effects in cobalamins and in their simple models.

Science.gov (United States)

De March, Matteo; Demitri, Nicola; Geremia, Silvano; Hickey, Neal; Randaccio, Lucio

2012-11-01

The interligand interactions in coordination compounds have been principally interpreted in terms of cis and trans influences and effects, which can be defined as the ability of a ligand X to affect the bond of another ligand, cis or trans to X, to the metal. This review analyzes these effects/influences in cobalamins (XCbl) and their simple models cobaloximes, LCo(chel)X. Important properties of these complexes, such as geometry, stability, and reactivity, can be rationalized in terms of steric and electronic factors of the ligands. Experimental evidence of normal and inverse trans influence is described in alkylcobaloximes for the first time. The study of simple B(12) models has complemented that on the more complex cobalamins, with particular emphasis on the properties of the axial L-Co-X moiety. Some of the conclusions reached for the axial fragment of simple models have also been qualitatively detected in cobalamins and have furnished new insight into the as yet unestablished mechanism for the homolytic cleavage of the Co - C bond in the AdoCbl-based enzymes. Copyright © 2012 Elsevier Inc. All rights reserved.

PERSONAS TRANS Y SU ADHERENCIA A LA TERAPIA ANTIRRETROVIRAL PARA EL VIH/SIDA

Directory of Open Access Journals (Sweden)

Milagros Del Carmen Meléndez Sáez

2015-01-01

Full Text Available La población de personas Trans es una poco estudiada. Los escasos estudios publicados sugieren que las personas Trans que viven con Virus de Inmunodeficiencia Humana/Síndrome de Inmunodeficiencia Adquirida (VIH/SIDA se enfrentan a retos únicos en cuanto a la adherencia y los cuidados de tratamiento de esta enfermedad. La complejidad de los factores asociados con la adherencia está implicada en una interacción dinámica entre las variables de comportamiento y el desarrollo cognitivo y emocional. El presente estudio con metodología mixta, tuvo como objetivo analizar y describir la relación entre las variables apoyo social, creencias de salud y depresión con el nivel de adherencia a los tratamientos antirretrovirales (TAR en una muestra de ocho personas Trans (N = 8 que viven con VIH/SIDA en Puerto Rico (PR. Los hallazgos demuestran que el factor principal para la adherencia a TAR es el apoyo social, lo que implica tener significancia clínica.