Silicon photonic integrated circuit swept-source optical coherence tomography receiver with dual polarization, dual balanced, in-phase and quadrature detection.

Science.gov (United States)

Wang, Zhao; Lee, Hsiang-Chieh; Vermeulen, Diedrik; Chen, Long; Nielsen, Torben; Park, Seo Yeon; Ghaemi, Allan; Swanson, Eric; Doerr, Chris; Fujimoto, James

2015-07-01

Optical coherence tomography (OCT) is a widely used three-dimensional (3D) optical imaging method with many biomedical and non-medical applications. Miniaturization, cost reduction, and increased functionality of OCT systems will be critical for future emerging clinical applications. We present a silicon photonic integrated circuit swept-source OCT (SS-OCT) coherent receiver with dual polarization, dual balanced, in-phase and quadrature (IQ) detection. We demonstrate multiple functional capabilities of IQ polarization resolved detection including: complex-conjugate suppressed full-range OCT, polarization diversity detection, and polarization-sensitive OCT. To our knowledge, this is the first demonstration of a silicon photonic integrated receiver for OCT. The integrated coherent receiver provides a miniaturized, low-cost solution for SS-OCT, and is also a key step towards a fully integrated high speed SS-OCT system with good performance and multi-functional capabilities. With further performance improvement and cost reduction, photonic integrated technology promises to greatly increase penetration of OCT systems in existing applications and enable new applications.

Phase-sensitive optical coherence tomography-based vibrometry using a highly phase-stable akinetic swept laser source

Energy Technology Data Exchange (ETDEWEB)

Applegate, Brian E.; Park, Jesung; Carbajal, Esteban [Department of Biomedical Engineering, Texas A& M University, College Station, Texas (United States); Oghalai, John S. [Department of Otolaryngology - Head and Neck Surgery, Stanford University, Stanford, California (United States)

2015-12-31

Phase-sensitive Optical Coherence Tomography (PhOCT) is an emerging tool for in vivo investigation of the vibratory function of the intact middle and inner ear. PhOCT is able to resolve micron scale tissue morphology in three dimensions as well as measure picometer scale motion at each spatial position. Most PhOCT systems to date have relied upon the phase stability offered by spectrometer detection. On the other hand swept laser source based PhOCT offers a number of advantages including balanced detection, long imaging depths, and high imaging speeds. Unfortunately the inherent phase instability of traditional swept laser sources has necessitated complex user developed hardware/software solutions to restore phase sensitivity. Here we present recent results using a prototype swept laser that overcomes these issues. The akinetic swept laser is electronically tuned and precisely controls sweeps without any mechanical movement, which results in high phase stability. We have developed an optical fiber based PhOCT system around the akinetic laser source that had a 1550 nm center wavelength and a sweep rate of 140 kHz. The stability of the system was measured to be 4.4 pm with a calibrated reflector, thus demonstrating near shot noise limited performance. Using this PhOCT system, we have acquired structural and vibratory measurements of the middle ear in a mouse model, post mortem. The quality of the results suggest that the akinetic laser source is a superior laser source for PhOCT with many advantages that greatly reduces the required complexity of the imaging system.

Vector method for strain estimation in phase-sensitive optical coherence elastography

Science.gov (United States)

Matveyev, A. L.; Matveev, L. A.; Sovetsky, A. A.; Gelikonov, G. V.; Moiseev, A. A.; Zaitsev, V. Y.

2018-06-01

A noise-tolerant approach to strain estimation in phase-sensitive optical coherence elastography, robust to decorrelation distortions, is discussed. The method is based on evaluation of interframe phase-variation gradient, but its main feature is that the phase is singled out at the very last step of the gradient estimation. All intermediate steps operate with complex-valued optical coherence tomography (OCT) signals represented as vectors in the complex plane (hence, we call this approach the ‘vector’ method). In comparison with such a popular method as least-square fitting of the phase-difference slope over a selected region (even in the improved variant with amplitude weighting for suppressing small-amplitude noisy pixels), the vector approach demonstrates superior tolerance to both additive noise in the receiving system and speckle-decorrelation caused by tissue straining. Another advantage of the vector approach is that it obviates the usual necessity of error-prone phase unwrapping. Here, special attention is paid to modifications of the vector method that make it especially suitable for processing deformations with significant lateral inhomogeneity, which often occur in real situations. The method’s advantages are demonstrated using both simulated and real OCT scans obtained during reshaping of a collagenous tissue sample irradiated by an IR laser beam producing complex spatially inhomogeneous deformations.

Optical Design in Phase-Space for the I13L X-Ray Imaging and Coherence Beamline at Diamond using XPHASY

International Nuclear Information System (INIS)

Wagner, Ulrich H.; Rau, Christoph

2010-01-01

I13L is a 250 m long beamline for imaging and coherent diffraction currently under construction at the Diamond Light Source. For modeling the beamline optics the phase-space based ray-tracing code XPHASY was developed, as general ray-tracing codes for x-rays do not easily allow studying the propagation of coherence along the beamline. In contrast to computational intensive wave-front propagation codes, which fully describe the propagation of a photon-beam along a beamline but obscure the impact of individual optical components onto the beamline performance, this code allows to quickly calculate the photon-beam propagation along the beamline and estimate the impact of individual components.In this paper we will discuss the optical design of the I13L coherence branch from the perspective of phase-space by using XPHASY. We will demonstrate how the phase-space representation of a photon-beam allows estimating the coherence length at any given position along the beamline. The impact of optical components on the coherence length and the effect of vibrations on the beamline performance will be discussed. The paper will demonstrate how the phase-space representation of photon-beams allows a more detailed insight into the optical performance of a coherence beamline than ray-tracing in real space.

Optical Coherence Tomography (OCT for Time-Resolved Imaging of Alveolar Dynamics in Mechanically Ventilated Rats

Directory of Open Access Journals (Sweden)

Christian Schnabel

2017-03-01

Full Text Available Though artificial ventilation is an essential life-saving treatment, the mechanical behavior of lung tissue at the alveolar level is still unknown. Therefore, we need to understand the tissue response during artificial ventilation at this microscale in order to develop new and more protective ventilation methods. Optical coherence tomography (OCT combined with intravital microscopy (IVM is a promising tool for visualizing lung tissue dynamics with a high spatial and temporal resolution in uninterruptedly ventilated rats. We present a measurement setup using a custom-made animal ventilator and a gating technique for data acquisition of time-resolved sequences.

Analytical Investigations on Carrier Phase Recovery in Dispersion-Unmanaged n-PSK Coherent Optical Communication Systems

Directory of Open Access Journals (Sweden)

Tianhua Xu

2016-09-01

Full Text Available Using coherent optical detection and digital signal processing, laser phase noise and equalization enhanced phase noise can be effectively mitigated using the feed-forward and feed-back carrier phase recovery approaches. In this paper, theoretical analyses of feed-back and feed-forward carrier phase recovery methods have been carried out in the long-haul high-speed n-level phase shift keying (n-PSK optical fiber communication systems, involving a one-tap normalized least-mean-square (LMS algorithm, a block-wise average algorithm, and a Viterbi-Viterbi algorithm. The analytical expressions for evaluating the estimated carrier phase and for predicting the bit-error-rate (BER performance (such as the BER floors have been presented and discussed in the n-PSK coherent optical transmission systems by considering both the laser phase noise and the equalization enhanced phase noise. The results indicate that the Viterbi-Viterbi carrier phase recovery algorithm outperforms the one-tap normalized LMS and the block-wise average algorithms for small phase noise variance (or effective phase noise variance, while the one-tap normalized LMS algorithm shows a better performance than the other two algorithms for large phase noise variance (or effective phase noise variance. In addition, the one-tap normalized LMS algorithm is more sensitive to the level of modulation formats.

Optical Coherence Tomography for Material Characterization

NARCIS (Netherlands)

Liu, P.

2014-01-01

Optical coherence tomography (OCT) is a non-invasive, contactless and high resolution imaging method, which allows the reconstruction of two or three dimensional depth-resolved images in turbid media. In the past 20 years, OCT has been extensively developed in the field of biomedical diagnostics,

Discrimination of optical coherent states using a photon number resolving detector

DEFF Research Database (Denmark)

Wittmann, C.; Andersen, Ulrik Lund; Leuchs, G.

2010-01-01

The discrimination of non-orthogonal quantum states with reduced or without errors is a fundamental task in quantum measurement theory. In this work, we investigate a quantum measurement strategy capable of discriminating two coherent states probabilistically with significantly smaller error...... probabilities than can be obtained using non-probabilistic state discrimination. We find that appropriate postselection of the measurement data of a photon number resolving detector can be used to discriminate two coherent states with small error probability. We compare our new receiver to an optimal...

Phase noise estimation and mitigation for DCT-based coherent optical OFDM systems.

Science.gov (United States)

Yang, Chuanchuan; Yang, Feng; Wang, Ziyu

2009-09-14

In this paper, as an attractive alternative to the conventional discrete Fourier transform (DFT) based orthogonal frequency division multiplexing (OFDM), discrete cosine transform (DCT) based OFDM which has certain advantages over its counterpart is studied for optical fiber communications. As is known, laser phase noise is a major impairment to the performance of coherent optical OFDM (CO-OFDM) systems. However, to our knowledge, detailed analysis of phase noise and the corresponding mitigation methods for DCT-based CO-OFDM systems have not been reported yet. To address these issues, we analyze the laser phase noise in the DCT-based CO-OFDM systems, and propose phase noise estimation and mitigation schemes. Numerical results show that the proposal is very effective in suppressing phase noise and could significantly improve the performance of DCT-based CO-OFDM systems.

Experimental study of coherence vortices: Local properties of phase singularities in a spatial coherence function

DEFF Research Database (Denmark)

Wang, W.; Duan, Z.H.; Hanson, Steen Grüner

2006-01-01

By controlling the irradiance of an extended quasimonochromatic, spatially incoherent source, an optical field is generated that exhibits spatial coherence with phase singularities, called coherence vortices. A simple optical geometry for direct visualization of coherence vortices is proposed, an...

Phase-controlled all-optical switching based on coherent population oscillation in a two-level system

International Nuclear Information System (INIS)

Liao, Ping; Yu, Song; Luo, Bin; Shen, Jing; Gu, Wanyi; Guo, Hong

2011-01-01

We theoretically propose a scheme of phase-controlled all-optical switching due to the effect of degenerate four-wave mixing (FWM) and coherent population oscillation (CPO) in a two-level system driven by a strong coupling field and two weak symmetrically detuned fields. The results show that the phase of the FWM field can be utilized to switch between constructive and destructive interference, which can lead to the transmission or attenuation of the probe field and thus switch the field on or off. We also find the intensity of the coupling field and the propagation distance have great influence on the performance of the switching. In our scheme, due to the quick response in semiconductor systems, a fast all-optical switching can be realized at low light level. -- Highlights: ► We study a new all-optical switching based on coherent population oscillation. ► The phase of the FWM field can be utilized to switch the probe field on or off. ► A fast and low-light-level switching can be realized in semiconductors.

Phase-controlled coherent population trapping in superconducting quantum circuits

International Nuclear Information System (INIS)

Cheng Guang-Ling; Wang Yi-Ping; Chen Ai-Xi

2015-01-01

We investigate the influences of the-applied-field phases and amplitudes on the coherent population trapping behavior in superconducting quantum circuits. Based on the interactions of the microwave fields with a single Δ-type three-level fluxonium qubit, the coherent population trapping could be obtainable and it is very sensitive to the relative phase and amplitudes of the applied fields. When the relative phase is tuned to 0 or π, the maximal atomic coherence is present and coherent population trapping occurs. While for the choice of π/2, the atomic coherence becomes weak. Meanwhile, for the fixed relative phase π/2, the value of coherence would decrease with the increase of Rabi frequency of the external field coupled with two lower levels. The responsible physical mechanism is quantum interference induced by the control fields, which is indicated in the dressed-state representation. The microwave coherent phenomenon is present in our scheme, which will have potential applications in optical communication and nonlinear optics in solid-state devices. (paper)

Three-dimensional optical coherence micro-elastography of skeletal muscle tissue

OpenAIRE

Chin, Lixin; Kennedy, Brendan F.; Kennedy, Kelsey M.; Wijesinghe, Philip; Pinniger, Gavin J.; Terrill, Jessica R.; McLaughlin, Robert A.; Sampson, David D.

2014-01-01

In many muscle pathologies, impairment of skeletal muscle function is closely linked to changes in the mechanical properties of the muscle constituents. Optical coherence micro-elastography (OCME) uses optical coherence tomography (OCT) imaging of tissue under a quasi-static, compressive mechanical load to map variations in tissue mechanical properties on the micro-scale. We present the first study of OCME on skeletal muscle tissue. We show that this technique can resolve features of muscle t...

Detailed Vascular Anatomy of the Human Retina by Projection-Resolved Optical Coherence Tomography Angiography

Science.gov (United States)

Campbell, J. P.; Zhang, M.; Hwang, T. S.; Bailey, S. T.; Wilson, D. J.; Jia, Y.; Huang, D.

2017-02-01

Optical coherence tomography angiography (OCTA) is a noninvasive method of 3D imaging of the retinal and choroidal circulations. However, vascular depth discrimination is limited by superficial vessels projecting flow signal artifact onto deeper layers. The projection-resolved (PR) OCTA algorithm improves depth resolution by removing projection artifact while retaining in-situ flow signal from real blood vessels in deeper layers. This novel technology allowed us to study the normal retinal vasculature in vivo with better depth resolution than previously possible. Our investigation in normal human volunteers revealed the presence of 2 to 4 distinct vascular plexuses in the retina, depending on location relative to the optic disc and fovea. The vascular pattern in these retinal plexuses and interconnecting layers are consistent with previous histologic studies. Based on these data, we propose an improved system of nomenclature and segmentation boundaries for detailed 3-dimensional retinal vascular anatomy by OCTA. This could serve as a basis for future investigation of both normal retinal anatomy, as well as vascular malformations, nonperfusion, and neovascularization.

MULTILEVEL ISCHEMIA IN DISORGANIZATION OF THE RETINAL INNER LAYERS ON PROJECTION-RESOLVED OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.

Science.gov (United States)

Onishi, Alex C; Ashraf, Mohammed; Soetikno, Brian T; Fawzi, Amani A

2018-04-10

To examine the relationship between ischemia and disorganization of the retinal inner layers (DRIL). Cross-sectional retrospective study of 20 patients (22 eyes) with diabetic retinopathy presenting to a tertiary academic referral center, who had DRIL on structural optical coherence tomography (OCT) using Spectralis HRA + OCT (Heidelberg Engineering, Heidelberg, Germany) and OCT angiography with XR Avanti (Optovue Inc, Fremont, CA) on the same day. Optical coherence tomography angiography images were further processed to remove flow signal projection artifacts using a software algorithm adapted from recent studies. Retinal capillary perfusion in the superficial capillary plexuses, middle capillary plexuses, and deep capillary plexuses, as well as integrity of the photoreceptor lines on OCT was compared in areas with DRIL to control areas without DRIL in the same eye. Qualitative assessment of projection-resolved OCT angiography of eyes with DRIL on structural OCT demonstrated significant perfusion deficits compared with adjacent control areas (P < 0.001). Most lesions (85.7%) showed superimposed superficial capillary plexus and/or middle capillary plexus nonperfusion in addition to deep capillary plexus nonflow. Areas of DRIL were significantly associated with photoreceptor disruption (P = 0.035) compared with adjacent DRIL-free areas. We found that DRIL is associated with multilevel retinal capillary nonperfusion, suggesting an important role for ischemia in this OCT phenotype.

Optical coherence tomography angiography changes in radial peripapillary capillaries in Leber hereditary optic neuropathy

Directory of Open Access Journals (Sweden)

Mitsuhiro Matsuzaki

2018-03-01

Conclusions and importance: Optical coherence tomography angiography showed LHON from the presymptomatic stage. The results indicate that temporal RPC defects and RFT thinning start to spread once the pseudoedema begins to resolve.

Towards non-invasive 3D hepatotoxicity assays with optical coherence phase microscopy

Science.gov (United States)

Nelson, Leonard J.; Koulovasilopoulos, Andreas; Treskes, Philipp; Hayes, Peter C.; Plevris, John N.; Bagnaninchi, Pierre O.

2015-03-01

Three-dimensional tissue-engineered models are increasingly recognised as more physiologically-relevant than standard 2D cell culture for pre-clinical drug toxicity testing. However, many types of conventional toxicity assays are incompatible with dense 3D tissues. This study investigated the use of optical coherence phase microscopy (OCPM) as a novel approach to assess cell death in 3D tissue culture. For 3D micro-spheroid formation Human hepatic C3A cells were encapsulated in hyaluronic acid gels and cultured in 100μl MEME/10%FBS in 96-well plates. After spheroid formation the 3D liver constructs were exposed to acetaminophen on culture day 8. Acetaminophen hepatotoxicity in 3D cultures was evaluated using standard biochemical assays. An inverted OCPM in common path configuration was developed with a Callisto OCT engine (Thorlabs), centred at 930nm and a custom scanning head. Intensity data were used to perform in-depth microstructural imaging. In addition, phase fluctuations were measured by collecting several successive B scans at the same location, and statistics on the first time derivative of the phase, i.e. time fluctuations, were analysed over the acquisition time interval to retrieve overall cell viability. OCPM intensity (cell cluster size) and phase fluctuation statistics were directly compared with biochemical assays. In this study, we investigated optical coherence phase tomography to assess cell death in a 3d liver model after exposure to a prototypical hepatotoxin, acetaminophen. We showed that OCPM has the potential to assess noninvasively and label-free drug toxicity in 3D tissue models.

Overlapped optics induced perfect coherent effects

Science.gov (United States)

Li, Jian Jie; Zang, Xiao Fei; Mao, Jun Fa; Tang, Min; Zhu, Yi Ming; Zhuang, Song Lin

2013-12-01

For traditional coherent effects, two separated identical point sources can be interfered with each other only when the optical path difference is integer number of wavelengths, leading to alternate dark and bright fringes for different optical path difference. For hundreds of years, such a perfect coherent condition seems insurmountable. However, in this paper, based on transformation optics, two separated in-phase identical point sources can induce perfect interference with each other without satisfying the traditional coherent condition. This shifting illusion media is realized by inductor-capacitor transmission line network. Theoretical analysis, numerical simulations and experimental results are performed to confirm such a kind of perfect coherent effect and it is found that the total radiation power of multiple elements system can be greatly enhanced. Our investigation may be applicable to National Ignition Facility (NIF), Inertial Confined Fusion (ICF) of China, LED lighting technology, terahertz communication, and so on.

Optimization of genetic algorithm for reconstruction of cross-phase modulation frequency-resolved optical gating data

Czech Academy of Sciences Publication Activity Database

Vraný, Boleslav; Honzátko, Pavel; Kaňka, Jiří

2011-01-01

Roč. 24, č. 5 (2011), 448-456 ISSN 0894-3370 R&D Projects: GA MŠk OE08021 Institutional research plan: CEZ:AV0Z20670512 Keywords : frequency resolved optical gating, FROG * amplitude and phase retrieval * genetic algorithm, GA Subject RIV: BH - Optics, Masers, Lasers Impact factor: 0.600, year: 2011

Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography (Conference Presentation)

Science.gov (United States)

Tang, Qinggong; Frank, Aaron; Wang, Jianting; Chen, Chao-wei; Jin, Lily; Lin, Jon; Chan, Joanne M.; Chen, Yu

2016-03-01

Early detection of neoplastic changes remains a critical challenge in clinical cancer diagnosis and treatment. Many cancers arise from epithelial layers such as those of the gastrointestinal (GI) tract. Current standard endoscopic technology is unable to detect those subsurface lesions. Since cancer development is associated with both morphological and molecular alterations, imaging technologies that can quantitative image tissue's morphological and molecular biomarkers and assess the depth extent of a lesion in real time, without the need for tissue excision, would be a major advance in GI cancer diagnostics and therapy. In this research, we investigated the feasibility of multi-modal optical imaging including high-resolution optical coherence tomography (OCT) and depth-resolved high-sensitivity fluorescence laminar optical tomography (FLOT) for structural and molecular imaging. APC (adenomatous polyposis coli) mice model were imaged using OCT and FLOT and the correlated histopathological diagnosis was obtained. Quantitative structural (the scattering coefficient) and molecular imaging parameters (fluorescence intensity) from OCT and FLOT images were developed for multi-parametric analysis. This multi-modal imaging method has demonstrated the feasibility for more accurate diagnosis with 87.4% (87.3%) for sensitivity (specificity) which gives the most optimal diagnosis (the largest area under receiver operating characteristic (ROC) curve). This project results in a new non-invasive multi-modal imaging platform for improved GI cancer detection, which is expected to have a major impact on detection, diagnosis, and characterization of GI cancers, as well as a wide range of epithelial cancers.

Optical Coherence and Quantum Optics

CERN Document Server

Mandel, Leonard

1995-01-01

This book presents a systematic account of optical coherence theory within the framework of classical optics, as applied to such topics as radiation from sources of different states of coherence, foundations of radiometry, effects of source coherence on the spectra of radiated fields, coherence theory of laser modes, and scattering of partially coherent light by random media. The book starts with a full mathematical introduction to the subject area and each chapter concludes with a set of exercises. The authors are renowned scientists and have made substantial contributions to many of the topi

IQ imbalance tolerable parallel-channel DMT transmission for coherent optical OFDMA access network

Science.gov (United States)

Jung, Sang-Min; Mun, Kyoung-Hak; Jung, Sun-Young; Han, Sang-Kook

2016-12-01

Phase diversity of coherent optical communication provides spectrally efficient higher-order modulation for optical communications. However, in-phase/quadrature (IQ) imbalance in coherent optical communication degrades transmission performance by introducing unwanted signal distortions. In a coherent optical orthogonal frequency division multiple access (OFDMA) passive optical network (PON), IQ imbalance-induced signal distortions degrade transmission performance by interferences of mirror subcarriers, inter-symbol interference (ISI), and inter-channel interference (ICI). We propose parallel-channel discrete multitone (DMT) transmission to mitigate transceiver IQ imbalance-induced signal distortions in coherent orthogonal frequency division multiplexing (OFDM) transmissions. We experimentally demonstrate the effectiveness of parallel-channel DMT transmission compared with that of OFDM transmission in the presence of IQ imbalance.

Generation of equal-intensity coherent optical beams by binary geometrical phase on metasurface

Energy Technology Data Exchange (ETDEWEB)

Wang, Zheng-Han; Jiang, Shang-Chi; Xiong, Xiang; Peng, Ru-Wen, E-mail: rwpeng@nju.edu.cn, E-mail: muwang@nju.edu.cn; Wang, Mu, E-mail: rwpeng@nju.edu.cn, E-mail: muwang@nju.edu.cn [National Laboratory of Solid State Microstructures and School of Physics, and Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093 (China)

2016-06-27

We report here the design and realization of a broadband, equal-intensity optical beam splitter with a dispersion-free binary geometric phase on a metasurface with unit cell consisting of two mirror-symmetric elements. We demonstrate experimentally that two identical beams can be efficiently generated with incidence of any polarization. The efficiency of the device reaches 80% at 1120 nm and keeps larger than 70% in the range of 1000–1400 nm. We suggest that this approach for generating identical, coherent beams have wide applications in diffraction optics and in entangled photon light source for quantum communication.

Optical coherence tomography angiography in age-related macular degeneration: The game changer.

Science.gov (United States)

Lupidi, Marco; Cerquaglia, Alessio; Chhablani, Jay; Fiore, Tito; Singh, Sumit Randhir; Cardillo Piccolino, Felice; Corbucci, Roberta; Coscas, Florence; Coscas, Gabriel; Cagini, Carlo

2018-04-01

Optical coherence tomography angiography is one of the biggest advances in ophthalmic imaging. It enables a depth-resolved assessment of the retinal and choroidal blood flow, far exceeding the levels of detail commonly obtained with dye angiographies. One of the first applications of optical coherence tomography angiography was in detecting the presence of choroidal neovascularization in age-related macular degeneration and establishing its position in relation to the retinal pigmented epithelium and Bruch's membrane, and thereby classifying the CNV as type 1, type 2, type 3, or mixed lesions. Optical coherence tomography angiograms, due to the longer wavelength used by optical coherence tomography, showed a more distinct choroidal neovascularization vascular pattern than fluorescein angiography, since there is less suffering from light scattering or is less obscured by overlying subretinal hemorrhages or exudation. Qualitative and quantitative assessments of optical coherence tomography angiography findings in exudative and nonexudative age-related macular degeneration have been largely investigated within the past 3 years both in clinical and experimental settings. This review constitutes an up-to-date of all the potential applications of optical coherence tomography angiography in age-related macular degeneration in order to better understand how to translate its theoretical usefulness into the current clinical practice.

Thermo-elastic optical coherence tomography.

Science.gov (United States)

Wang, Tianshi; Pfeiffer, Tom; Wu, Min; Wieser, Wolfgang; Amenta, Gaetano; Draxinger, Wolfgang; van der Steen, Antonius F W; Huber, Robert; Soest, Gijs van

2017-09-01

The absorption of nanosecond laser pulses induces rapid thermo-elastic deformation in tissue. A sub-micrometer scale displacement occurs within a few microseconds after the pulse arrival. In this Letter, we investigate the laser-induced thermo-elastic deformation using a 1.5 MHz phase-sensitive optical coherence tomography (OCT) system. A displacement image can be reconstructed, which enables a new modality of phase-sensitive OCT, called thermo-elastic OCT. An analysis of the results shows that the optical absorption is a dominating factor for the displacement. Thermo-elastic OCT is capable of visualizing inclusions that do not appear on the structural OCT image, providing additional tissue type information.

Absolute measurement of subnanometer scale vibration of cochlear partition of an excised guinea pig cochlea using spectral-domain phase-sensitive optical coherence tomography

Science.gov (United States)

Subhash, Hrebesh M.; Choudhury, Niloy; Jacques, Steven L.; Wang, Ruikang K.; Chen, Fangyi; Zha, Dingjun; Nuttall, Alfred L.

2012-01-01

Direct measurement of absolute vibration parameters from different locations within the mammalian organ of Corti is crucial for understanding the hearing mechanics such as how sound propagates through the cochlea and how sound stimulates the vibration of various structures of the cochlea, namely, basilar membrane (BM), recticular lamina, outer hair cells and tectorial membrane (TM). In this study we demonstrate the feasibility a modified phase-sensitive spectral domain optical coherence tomography system to provide subnanometer scale vibration information from multiple angles within the imaging beam. The system has the potential to provide depth resolved absolute vibration measurement of tissue microstructures from each of the delay-encoded vibration images with a noise floor of ~0.3nm at 200Hz.

Geometric phases for nonlinear coherent and squeezed states

International Nuclear Information System (INIS)

Yang Dabao; Chen Ying; Chen Jingling; Zhang Fulin

2011-01-01

The geometric phases for standard coherent states which are widely used in quantum optics have attracted considerable attention. Nevertheless, few physicists consider the counterparts of nonlinear coherent states, which are useful in the description of the motion of a trapped ion. In this paper, the non-unitary and non-cyclic geometric phases for two nonlinear coherent and one squeezed states are formulated, respectively. Moreover, some of their common properties are discussed, such as gauge invariance, non-locality and nonlinear effects. The nonlinear functions have dramatic impacts on the evolution of the corresponding geometric phases. They speed the evolution up or down. So this property may have an application in controlling or measuring geometric phase. For the squeezed case, when the squeezed parameter r → ∞, the limiting value of the geometric phase is also determined by a nonlinear function at a given time and angular velocity. In addition, the geometric phases for standard coherent and squeezed states are obtained under a particular condition. When the time evolution undergoes a period, their corresponding cyclic geometric phases are achieved as well. And the distinction between the geometric phases of the two coherent states may be regarded as a geometric criterion.

Near-infrared optical coherence tomography for the inspection of fiber composites

NARCIS (Netherlands)

Liu, P.; Yao, L.; Groves, R.M.

2015-01-01

Optical coherence tomography (OCT) is a non-invasive imaging method, which allows the econstruction of three dimensional depth-resolved images with microscale resolution. Originally developed for biomedical diagnostics, nowadays it also shows a high potential for applications in the field of

Principles of optical fibre communication techniques: Noncoherent and coherent

International Nuclear Information System (INIS)

Jain, V.K.

1990-01-01

In this paper a brief historical description of optical fibre communication system (OFCS) has been presented and the main characteristics of the basic components used in it are summarized. Introduction of noncoherent and coherent (homodyne and heterodyne) system is given. In coherent OFCS, source linewidth requirement, phase and polarization - diversity and combined phase and polarization - diversity receivers are described. (author). 16 refs, 8 figs, 1 tab

Path-length-resolved measurements of multiple scattered photons in static and dynamic turbid media using phase-modulated low-coherence interferometry

NARCIS (Netherlands)

Varghese, Babu; Rajan, Vinayakrishnan; van Leeuwen, Ton G.; Steenbergen, Wiendelt

2007-01-01

In optical Doppler measurements, the path length of the light is unknown. To facilitate quantitative measurements, we develop a phase-modulated Mach-Zehnder interferometer with separate fibers for illumination and detection. With this setup, path-length-resolved dynamic light scattering measurements

Widely Linear Equalization for IQ Imbalance and Skew Compensation in Optical Coherent Receivers

DEFF Research Database (Denmark)

Porto da Silva, Edson; Zibar, Darko

2016-01-01

In this paper, an alternative approach to design linear equalization algorithms for optical coherent receivers is introduced. Using widely linear complex analysis, a general analytical model it is shown, where In-phase/quadrature (IQ) imbalances and IQ skew at the coherent receiver front-end are ......In this paper, an alternative approach to design linear equalization algorithms for optical coherent receivers is introduced. Using widely linear complex analysis, a general analytical model it is shown, where In-phase/quadrature (IQ) imbalances and IQ skew at the coherent receiver front...

Monitoring of temperature-mediated phase transitions of adipose tissue by combined optical coherence tomography and Abbe refractometry.

Science.gov (United States)

Yanina, Irina Y; Popov, Alexey P; Bykov, Alexander V; Meglinski, Igor V; Tuchin, Valery V

2018-01-01

Observation of temperature-mediated phase transitions between lipid components of the adipose tissues has been performed by combined use of the Abbe refractometry and optical coherence tomography. The phase transitions of the lipid components were clearly observed in the range of temperatures from 24°C to 60°C, and assessed by quantitatively monitoring the changes of the refractive index of 1- to 2-mm-thick porcine fat tissue slices. The developed approach has a great potential as an alternative method for obtaining accurate information on the processes occurring during thermal lipolysis. (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE).

Optical coherence tomography in gastroenterology: a review and future outlook

Science.gov (United States)

Tsai, Tsung-Han; Leggett, Cadman L.; Trindade, Arvind J.; Sethi, Amrita; Swager, Anne-Fré; Joshi, Virendra; Bergman, Jacques J.; Mashimo, Hiroshi; Nishioka, Norman S.; Namati, Eman

2017-12-01

Optical coherence tomography (OCT) is an imaging technique optically analogous to ultrasound that can generate depth-resolved images with micrometer-scale resolution. Advances in fiber optics and miniaturized actuation technologies allow OCT imaging of the human body and further expand OCT utilization in applications including but not limited to cardiology and gastroenterology. This review article provides an overview of current OCT development and its clinical utility in the gastrointestinal tract, including disease detection/differentiation and endoscopic therapy guidance, as well as a discussion of its future applications.

Digital coherent superposition of optical OFDM subcarrier pairs with Hermitian symmetry for phase noise mitigation.

Science.gov (United States)

Yi, Xingwen; Chen, Xuemei; Sharma, Dinesh; Li, Chao; Luo, Ming; Yang, Qi; Li, Zhaohui; Qiu, Kun

2014-06-02

Digital coherent superposition (DCS) provides an approach to combat fiber nonlinearities by trading off the spectrum efficiency. In analogy, we extend the concept of DCS to the optical OFDM subcarrier pairs with Hermitian symmetry to combat the linear and nonlinear phase noise. At the transmitter, we simply use a real-valued OFDM signal to drive a Mach-Zehnder (MZ) intensity modulator biased at the null point and the so-generated OFDM signal is Hermitian in the frequency domain. At receiver, after the conventional OFDM signal processing, we conduct DCS of the optical OFDM subcarrier pairs, which requires only conjugation and summation. We show that the inter-carrier-interference (ICI) due to phase noise can be reduced because of the Hermitain symmetry. In a simulation, this method improves the tolerance to the laser phase noise. In a nonlinear WDM transmission experiment, this method also achieves better performance under the influence of cross phase modulation (XPM).

Photothermal optical coherence tomography for depth-resolved imaging of mesenchymal stem cells via single wall carbon nanotubes

Science.gov (United States)

Subhash, Hrebesh M.; Connolly, Emma; Murphy, Mary; Barron, Valerie; Leahy, Martin

2014-03-01

The progress in stem cell research over the past decade holds promise and potential to address many unmet clinical therapeutic needs. Tracking stem cell with modern imaging modalities are critically needed for optimizing stem cell therapy, which offers insight into various underlying biological processes such as cell migration, engraftment, homing, differentiation, and functions etc. In this study we report the feasibility of photothermal optical coherence tomography (PT-OCT) to image human mesenchymal stem cells (hMSCs) labeled with single-walled carbon nanotubes (SWNTs) for in vitro cell tracking in three dimensional scaffolds. PT-OCT is a functional extension of conventional OCT with extended capability of localized detection of absorbing targets from scattering background to provide depth-resolved molecular contrast imaging. A 91 kHz line rate, spectral domain PT-OCT system at 1310nm was developed to detect the photothermal signal generated by 800nm excitation laser. In general, MSCs do not have obvious optical absorption properties and cannot be directly visualized using PT-OCT imaging. However, the optical absorption properties of hMSCs can me modified by labeling with SWNTs. Using this approach, MSC were labeled with SWNT and the cell distribution imaged in a 3D polymer scaffold using PT-OCT.

The Atomic, Molecular and Optical Science instrument at the Linac Coherent Light Source

Energy Technology Data Exchange (ETDEWEB)

Ferguson, Ken R. [Linac Coherent Light Source, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States); Department of Applied Physics, Stanford University, 348 Via Pueblo, Stanford, CA 94305 (United States); Bucher, Maximilian; Bozek, John D.; Carron, Sebastian; Castagna, Jean-Charles [Linac Coherent Light Source, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States); Coffee, Ryan [Linac Coherent Light Source, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States); Pulse Institute, Stanford University and SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States); Curiel, G. Ivan; Holmes, Michael; Krzywinski, Jacek; Messerschmidt, Marc; Minitti, Michael; Mitra, Ankush; Moeller, Stefan; Noonan, Peter; Osipov, Timur; Schorb, Sebastian; Swiggers, Michele; Wallace, Alexander; Yin, Jing [Linac Coherent Light Source, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States); Bostedt, Christoph, E-mail: bostedt@slac.stanford.edu [Linac Coherent Light Source, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States); Pulse Institute, Stanford University and SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States)

2015-04-17

A description of the Atomic, Molecular and Optical Sciences (AMO) instrument at the Linac Coherent Light Source is presented. Recent scientific highlights illustrate the imaging, time-resolved spectroscopy and high-power density capabilities of the AMO instrument. The Atomic, Molecular and Optical Science (AMO) instrument at the Linac Coherent Light Source (LCLS) provides a tight soft X-ray focus into one of three experimental endstations. The flexible instrument design is optimized for studying a wide variety of phenomena requiring peak intensity. There is a suite of spectrometers and two photon area detectors available. An optional mirror-based split-and-delay unit can be used for X-ray pump–probe experiments. Recent scientific highlights illustrate the imaging, time-resolved spectroscopy and high-power density capabilities of the AMO instrument.

Performance improvement of coherent free-space optical communication with quadrature phase-shift keying modulation using digital phase estimation.

Science.gov (United States)

Li, Xueliang; Geng, Tianwen; Ma, Shuang; Li, Yatian; Gao, Shijie; Wu, Zhiyong

2017-06-01

The performance of coherent free-space optical (CFSO) communication with phase modulation is limited by both phase fluctuations and intensity scintillations induced by atmospheric turbulence. To improve the system performance, one effective way is to use digital phase estimation. In this paper, a CFSO communication system with quadrature phase-shift keying modulation is studied. With consideration of the effects of log-normal amplitude fluctuations and Gauss phase fluctuations, a two-stage Mth power carrier phase estimation (CPE) scheme is proposed. The simulation results show that the phase noise can be suppressed greatly by this scheme, and the system symbol error rate performance with the two-stage Mth power CPE can be three orders lower than that of the single-stage Mth power CPE. Therefore, the two-stage CPE we proposed can contribute to the performance improvements of the CFSO communication system and has determinate guidance sense to its actual application.

Three-Dimensional Optical Coherence Tomography (3D OCT), Phase II

Data.gov (United States)

National Aeronautics and Space Administration — Applied Science Innovations, Inc. proposes a new tool of 3D optical coherence tomography (OCT) for cellular level imaging at video frame rates and dramatically...

Phase-Sensitive Coherence and the Classical-Quantum Boundary in Ghost Imaging

Science.gov (United States)

Erkmen, Baris I.; Hardy, Nicholas D.; Venkatraman, Dheera; Wong, Franco N. C.; Shapiro, Jeffrey H.

2011-01-01

The theory of partial coherence has a long and storied history in classical statistical optics. the vast majority of this work addresses fields that are statistically stationary in time, hence their complex envelopes only have phase-insensitive correlations. The quantum optics of squeezed-state generation, however, depends on nonlinear interactions producing baseband field operators with phase-insensitive and phase-sensitive correlations. Utilizing quantum light to enhance imaging has been a topic of considerable current interest, much of it involving biphotons, i.e., streams of entangled-photon pairs. Biphotons have been employed for quantum versions of optical coherence tomography, ghost imaging, holography, and lithography. However, their seemingly quantum features have been mimicked with classical-sate light, questioning wherein lies the classical-quantum boundary. We have shown, for the case of Gaussian-state light, that this boundary is intimately connected to the theory of phase-sensitive partial coherence. Here we present that theory, contrasting it with the familiar case of phase-insensitive partial coherence, and use it to elucidate the classical-quantum boundary of ghost imaging. We show, both theoretically and experimentally, that classical phase-sensitive light produces ghost imaging most closely mimicking those obtained in biphotons, and we derived the spatial resolution, image contrast, and signal-to-noise ratio of a standoff-sensing ghost imager, taking into account target-induced speckle.

Phase contrast imaging with coherent high energy X-rays

Energy Technology Data Exchange (ETDEWEB)

Snigireva, I. [ESRF, Grenoble (France)

1997-02-01

X-ray imaging concern high energy domain (>6 keV) like a contact radiography, projection microscopy and tomography is used for many years to discern the features of the internal structure non destructively in material science, medicine and biology. In so doing the main contrast formation is absorption that makes some limitations for imaging of the light density materials and what is more the resolution of these techniques is not better than 10-100 {mu}m. It was turned out that there is now way in which to overcome 1{mu}m or even sub-{mu}m resolution limit except phase contrast imaging. It is well known in optics that the phase contrast is realised when interference between reference wave front and transmitted through the sample take place. Examples of this imaging are: phase contrast microscopy suggested by Zernike and Gabor (in-line) holography. Both of this techniques: phase contrast x-ray microscopy and holography are successfully progressing now in soft x-ray region. For imaging in the hard X-rays to enhance the contrast and to be able to resolve phase variations across the beam the high degree of the time and more importantly spatial coherence is needed. Because of this it was reasonable that the perfect crystal optics was involved like Bonse-Hart interferometry, double-crystal and even triple-crystal set-up using Laue and Bragg geometry with asymmetrically cut crystals.

Assessment of wave propagation on surfaces of crystalline lens with phase sensitive optical coherence tomography

International Nuclear Information System (INIS)

Manapuram, R K; Larin, K V; Baranov, S A; Manne, V G R; Mashiatulla, M; Sudheendran, N; Aglyamov, S; Emelianov, S

2011-01-01

We propose a real-time technique based on phase-sensitive swept source optical coherence tomography (PhS-SSOCT) modality for noninvasive quantification of very small optical path length changes produced on the surface of a mouse crystalline lens. Propagation of submicron mechanical waves on the surface of the lens was induced by periodic mechanical stimulation. Obtained results demonstrate that the described method is capable of detecting minute damped vibrations with amplitudes as small as 30 nanometers on the lens surface and hence, PhS-SSOCT could be potentially used to assess biomechanical properties of a crystalline lens with high accuracy and sensitivity

Experimental generation of optical coherence lattices

Energy Technology Data Exchange (ETDEWEB)

Chen, Yahong; Cai, Yangjian, E-mail: serpo@dal.ca, E-mail: yangjiancai@suda.edu.cn [College of Physics, Optoelectronics and Energy and Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215006 (China); Key Lab of Advanced Optical Manufacturing Technologies of Jiangsu Province and Key Lab of Modern Optical Technologies of Education Ministry of China, Soochow University, Suzhou 215006 (China); Ponomarenko, Sergey A., E-mail: serpo@dal.ca, E-mail: yangjiancai@suda.edu.cn [Department of Electrical and Computer Engineering, Dalhousie University, Halifax, Nova Scotia B3J 2X4 (Canada)

2016-08-08

We report experimental generation and measurement of recently introduced optical coherence lattices. The presented optical coherence lattice realization technique hinges on a superposition of mutually uncorrelated partially coherent Schell-model beams with tailored coherence properties. We show theoretically that information can be encoded into and, in principle, recovered from the lattice degree of coherence. Our results can find applications to image transmission and optical encryption.

Optical phase nanoscopy in red blood cells using low-coherence spectroscopy.

Science.gov (United States)

Shock, Itay; Barbul, Alexander; Girshovitz, Pinhas; Nevo, Uri; Korenstein, Rafi; Shaked, Natan T

2012-10-01

We propose a low-coherence spectral-domain phase microscopy (SDPM) system for accurate quantitative phase measurements in red blood cells (RBCs) for the prognosis and monitoring of disease conditions that affect the visco-elastic properties of RBCs. Using the system, we performed time-recordings of cell membrane fluctuations, and compared the nano-scale fluctuation dynamics of healthy and glutaraldehyde-treated RBCs. Glutaraldehyde-treated RBCs possess lower amplitudes of fluctuations, reflecting an increased membrane stiffness. To demonstrate the ability of our system to measure fluctuations of lower amplitudes than those measured by the commonly used holographic phase microscopy techniques, we also constructed wide-field digital interferometry (WFDI) system and compared the performances of both systems. Due to its common-path geometry, the optical-path-delay stability of SDPM was found to be less than 0.3 nm in liquid environment, at least three times better than WFDI under the same conditions. In addition, due to the compactness of SDPM and its inexpensive and robust design, the system possesses a high potential for clinical applications.

Optical coherence tomography technology and applications

CERN Document Server

Fujimoto, James

2015-01-01

Optical coherence tomography (OCT) is the optical analog of ultrasound imaging and is a powerful imaging technique that enables non-invasive, in vivo, high resolution, cross-sectional imaging in biological tissue.  Between 30 to 40 Million OCT imaging procedures are performed per year in ophthalmology.  The overall market is estimated at more than 0.5 Billion USD.  A new generation OCT technology was developed, dramatically increasing resolution and speed, achieving in vivo optical biopsy, i.e. the visualization of tissue architectural morphology in situ and in real time.  Functional extensions of OCT technology enable non-invasive, depth resolved functional assessment and imaging of tissue.  The book introduces OCT technology and applications not only from an optical and technological viewpoint, but also from the biomedical and clinical perspective. This second edition is widely extended and covers significantly more topics then the first edition of this book. The chapters are written leading intern...

Optical coherence elastography for evaluating customized riboflavin/UV-A corneal collagen crosslinking

Science.gov (United States)

Singh, Manmohan; Li, Jiasong; Vantipalli, Srilatha; Han, Zhaolong; Larin, Kirill V.; Twa, Michael D.

2017-09-01

UV-induced collagen cross-linking is a promising treatment for keratoconus that stiffens corneal tissue and prevents further degeneration. Since keratoconus is generally localized, the efficacy of collagen cross-linking (CXL) treatments could be improved by stiffening only the weakened parts of the cornea. Here, we demonstrate that optical coherence elastography (OCE) can spatially resolve transverse variations in corneal stiffness. A short duration (≤1 ms) focused air-pulse induced low amplitude (≤10 μm) deformations in the samples that were detected using a phase-stabilized optical coherence tomography system. A two-dimensional map of material stiffness was generated by measuring the damped natural frequency (DNF) of the air-pulse induced response at various transverse locations of a heterogeneous phantom mimicking a customized CXL treatment. After validation on the phantoms, similar OCE measurements were made on spatially selective CXL-treated in situ rabbit corneas. The results showed that this technique was able to clearly distinguish the untreated and CXL-treated regions of the cornea, where CXL increased the DNF of the cornea by ˜51%. Due to the noncontact nature and minimal excitation force, this technique may be valuable for in vivo assessments of corneal biomechanical properties.

Phase-Modulated Optical Communication Systems

CERN Document Server

Ho, Keang-Po

2005-01-01

Fiber-optic communication systems have revolutionized our telecommunication infrastructures – currently, almost all telephone land-line, cellular, and internet communications must travel via some form of optical fibers. In these transmission systems, neither the phase nor frequency of the optical signal carries information – only the intensity of the signal is used. To transmit more information in a single optical carrier, the phase of the optical carrier must be explored. As a result, there is renewed interest in phase-modulated optical communications, mainly in direct-detection DPSK signals for long-haul optical communication systems. When optical amplifiers are used to maintain certain signal level among the fiber link, the system is limited by amplifier noises and fiber nonlinearities. Phase-Modulated Optical Communication Systems surveys this newly popular area, covering the following topics: The transmitter and receiver for phase-modulated coherent lightwave systems Method for performance analysis o...

Investigation of optical currents in coherent and partially coherent vector fields

DEFF Research Database (Denmark)

Angelsky, O. V.; Gorsky, M. P.; Maksimyak, P. P.

2011-01-01

We present the computer simulation results of the spatial distri-bution of the Poynting vector and illustrate motion of micro and nanopar-ticles in spatially inhomogeneously polarized fields. The influence of phase relations and the degree of mutual coherence of superimposing waves...... by polarization characteristics of an optical field alone, using nanoscale me-tallic particles has been shown experimentally....

Coherent hard x-ray focusing optics and applications

Energy Technology Data Exchange (ETDEWEB)

Yun, W.B.; Viccaro, P.J.; Chrzas, J.; Lai, B.

1991-01-01

Coherent hard x-ray beams with a flux exceeding 10{sup 9} photons/second with a bandwidth of 0.1% will be provided by the undulator at the third generation synchrotron radiation sources such as APS, ESRF, and Spring-8. The availability of such high flux coherent x-ray beams offers excellent opportunities for extending the coherence-based techniques developed in the visible and soft x-ray part of the electromagnetic spectrum to the hard x-rays. These x-ray techniques (e.g., diffraction limited microfocusing, holography, interferometry, phase contrast imaging and signal enhancement), may offer substantial advantages over non-coherence-based x-ray techniques currently used. For example, the signal enhancement technique may be used to enhance an anomalous x-ray or magnetic x-ray scattering signal by several orders of magnitude. Coherent x-rays can be focused to a very small (diffraction-limited) spot size, thus allowing high spatial resolution microprobes to be constructed. The paper will discuss the feasibility of the extension of some coherence-based techniques to the hard x-ray range and the significant progress that has been made in the development of diffraction-limited focusing optics. Specific experimental results for a transmission Fresnel phase zone plate that can focus 8.2 keV x-rays to a spot size of about 2 microns will be briefly discussed. The comparison of measured focusing efficiency of the zone plate with that calculated will be made. Some specific applications of zone plates as coherent x-ray optics will be discussed. 17 refs., 4 figs.

On marginally resolved objects in optical interferometry

Science.gov (United States)

Lachaume, R.

2003-03-01

With the present and soon-to-be breakthrough of optical interferometry, countless objects shall be within reach of interferometers; yet, most of them are expected to remain only marginally resolved with hectometric baselines. In this paper, we tackle the problem of deriving the properties of a marginally resolved object from its optical visibilities. We show that they depend on the moments of flux distribution of the object: centre, mean angular size, asymmetry, and curtosis. We also point out that the visibility amplitude is a second-order phenomenon, whereas the phase is a combination of a first-order term, giving the location of the photocentre, and a third-order term, more difficult to detect than the visibility amplitude, giving an asymmetry coefficient of the object. We then demonstrate that optical visibilities are not a good model constraint while the object stays marginally resolved, unless observations are carried out at different wavelengths. Finally, we show an application of this formalism to circumstellar discs.

Experimental demonstration of spatially coherent beam combining using optical parametric amplification.

Science.gov (United States)

Kurita, Takashi; Sueda, Keiichi; Tsubakimoto, Koji; Miyanaga, Noriaki

2010-07-05

We experimentally demonstrated coherent beam combining using optical parametric amplification with a nonlinear crystal pumped by random-phased multiple-beam array of the second harmonic of a Nd:YAG laser at 10-Hz repetition rate. In the proof-of-principle experiment, the phase jump between two pump beams was precisely controlled by a motorized actuator. For the demonstration of multiple-beam combining a random phase plate was used to create random-phased beamlets as a pump pulse. Far-field patterns of the pump, the signal, and the idler indicated that the spatially coherent signal beams were obtained on both cases. This approach allows scaling of the intensity of optical parametric chirped pulse amplification up to the exa-watt level while maintaining diffraction-limited beam quality.

Imaging of Phase Objects using Partially Coherent Illumination

Energy Technology Data Exchange (ETDEWEB)

Ravizza, F. L. [Univ. of Arizona, Tucson, AZ (United States)

2013-01-01

Screening high-power laser optics for light intensifying phase objects that cause laserinduced damage on downstream optics is critical to sustaining laser operation. Identifying such flaws on large-apertures is quite challenging since they are relatively small and invisible to conventional inspection methods. A Linescan Phase Differential Imaging (LPDI) system was developed to rapidly identify these flaws on large-aperture optics within a single full-aperture dark-field image. We describe a two-step production phase object screening process consisting of LPDI mapping and image analysis, followed by high-resolution interferometry and propagation based evaluation of the downstream damage potential of identified flaws. An image simulation code capable of modeling the LPDI partially coherent illumination was used to optimize its phase object sensitivity.

IMAGING WITH MULTIMODAL ADAPTIVE-OPTICS OPTICAL COHERENCE TOMOGRAPHY IN MULTIPLE EVANESCENT WHITE DOT SYNDROME: THE STRUCTURE AND FUNCTIONAL RELATIONSHIP.

Science.gov (United States)

Labriola, Leanne T; Legarreta, Andrew D; Legarreta, John E; Nadler, Zach; Gallagher, Denise; Hammer, Daniel X; Ferguson, R Daniel; Iftimia, Nicusor; Wollstein, Gadi; Schuman, Joel S

2016-01-01

To elucidate the location of pathological changes in multiple evanescent white dot syndrome (MEWDS) with the use of multimodal adaptive optics (AO) imaging. A 5-year observational case study of a 24-year-old female with recurrent MEWDS. Full examination included history, Snellen chart visual acuity, pupil assessment, intraocular pressures, slit lamp evaluation, dilated fundoscopic exam, imaging with Fourier-domain optical coherence tomography (FD-OCT), blue-light fundus autofluorescence (FAF), fundus photography, fluorescein angiography, and adaptive-optics optical coherence tomography. Three distinct acute episodes of MEWDS occurred during the period of follow-up. Fourier-domain optical coherence tomography and adaptive-optics imaging showed disturbance in the photoreceptor outer segments (PR OS) in the posterior pole with each flare. The degree of disturbance at the photoreceptor level corresponded to size and extent of the visual field changes. All findings were transient with delineation of the photoreceptor recovery from the outer edges of the lesion inward. Hyperautofluorescence was seen during acute flares. Increase in choroidal thickness did occur with each active flare but resolved. Although changes in the choroid and RPE can be observed in MEWDS, Fourier-domain optical coherence tomography, and multimodal adaptive optics imaging localized the visually significant changes seen in this disease at the level of the photoreceptors. These transient retinal changes specifically occur at the level of the inner segment ellipsoid and OS/RPE line. En face optical coherence tomography imaging provides a detailed, yet noninvasive method for following the convalescence of MEWDS and provides insight into the structural and functional relationship of this transient inflammatory retinal disease.

Optical Coherence Tomography

DEFF Research Database (Denmark)

Mogensen, Mette; Themstrup, Lotte; Banzhaf, Christina

2014-01-01

Optical coherence tomography (OCT) has developed rapidly since its first realisation in medicine and is currently an emerging technology in the diagnosis of skin disease. OCT is an interferometric technique that detects reflected and backscattered light from tissue and is often described as the o......Optical coherence tomography (OCT) has developed rapidly since its first realisation in medicine and is currently an emerging technology in the diagnosis of skin disease. OCT is an interferometric technique that detects reflected and backscattered light from tissue and is often described...

Numerical modeling of optical coherent transient processes with complex configurations-III: Noisy laser source

International Nuclear Information System (INIS)

Chang Tiejun; Tian Mingzhen

2007-01-01

A previously developed numerical model based on Maxwell-Bloch equations was modified to simulate optical coherent transient and spectral hole burning processes with noisy laser sources. Random walk phase noise was simulated using laser-phase sequences generated numerically according to the normal distribution of the phase shift. The noise model was tested by comparing the simulated spectral hole burning effect with the analytical solution. The noise effects on a few typical optical coherence transient processes were investigated using this numerical tool. Flicker and random walk frequency noises were considered in accumulation process

In vivo imaging of human photoreceptor mosaic with wavefront sensorless adaptive optics optical coherence tomography.

Science.gov (United States)

Wong, Kevin S K; Jian, Yifan; Cua, Michelle; Bonora, Stefano; Zawadzki, Robert J; Sarunic, Marinko V

2015-02-01

Wavefront sensorless adaptive optics optical coherence tomography (WSAO-OCT) is a novel imaging technique for in vivo high-resolution depth-resolved imaging that mitigates some of the challenges encountered with the use of sensor-based adaptive optics designs. This technique replaces the Hartmann Shack wavefront sensor used to measure aberrations with a depth-resolved image-driven optimization algorithm, with the metric based on the OCT volumes acquired in real-time. The custom-built ultrahigh-speed GPU processing platform and fast modal optimization algorithm presented in this paper was essential in enabling real-time, in vivo imaging of human retinas with wavefront sensorless AO correction. WSAO-OCT is especially advantageous for developing a clinical high-resolution retinal imaging system as it enables the use of a compact, low-cost and robust lens-based adaptive optics design. In this report, we describe our WSAO-OCT system for imaging the human photoreceptor mosaic in vivo. We validated our system performance by imaging the retina at several eccentricities, and demonstrated the improvement in photoreceptor visibility with WSAO compensation.

Optimization of phase-variation measurements in low-coherence methods: implications for OCE

Science.gov (United States)

Zaitsev, Vladimir Y.; Matveyev, Alexandr L.; Matveev, Lev A.; Gelikonov, Grigory V.; Sovetsky, Alexander A.; Vitkin, Alex

2016-04-01

Phase-resolved measurements found numerous applications in low-coherence methods, in particular in OCT-based compressional elastography, where phase-variation gradients are used for estimating strains produced by the OCT probe pressed onto the tissue. Conventionally, for the reference and deformed pixelated OCT scans, one performs comparison of phases taken from pixels with the same coordinates. This is reasonable in regions of sufficiently small sub-pixel displacements, for which the so-compared pixels contain the same scatterers. Furthermore, to avoid error-prone multiple phase unwrapping for reconstructing displacements, one have to ensure even smaller sub-wavelength displacements. This limits the allowable strains to less than ~10-4-10-3, although such weak phase gradients can be strongly corrupted by measurement noises. Here, we discuss how creation of an order of magnitude greater strains can be used for increasing the signal-to noise ratio in estimating phase gradients by obviating the phase-unwrapping procedures and reducing the influence of decorrelation noise for supra-pixel displacements. This optimized phase-variation measurement makes it possible to perform strain mapping in optical coherence elastography with exceptionally high tolerance to noises due to possibility of using significantly increased strains. We also discuss the effect of "frozen-phase zones" associated with displaced strong scatterers. This effect can result in appearance of artifacts in the form of false stiff inclusions in elastograms in the vicinity of bright scatterers in OCT scans. We present analytical arguments, numerical simulations and experimental examples illustrating the above-mentioned features of the "frozen-phase" effect and advantages of using the proposed optimized phase-variation measurement with pixel-scale displacement compensation in the compared OCT scans.

Optimization of a coherent soft x-ray beamline for coherent scattering experiments at NSLS-II

Energy Technology Data Exchange (ETDEWEB)

Shapiro D.; Chubar, O.; Kaznatcheev, K.; Reininger, R.; Sanchez-Hanke, C.; Wang, S.

2011-08-21

The coherent soft x-ray and full polarization control (CSX) beamline at the National Synchrotron Light Source - II (NSLS-II) will deliver 1013 coherent photons per second in the energy range of 0.2-2 keV with a resolving power of 2000. The source, a dual elliptically polarizing undulator (EPU), and beamline optics should be optimized to deliver the highest possible coherent flux in a 10-30 {micro}m spot for use in coherent scattering experiments. Using the computer code Synchrotron Radiation Workshop (SRW), we simulate the photon source and focusing optics in order to investigate the conditions which provide the highest usable coherent intensity on the sample. In particular, we find that an intermediate phasing magnet is needed to correct for the relative phase between the two EPUs and that the optimum phase setting produces a spectrum in which the desired wavelength is slightly red-shifted thus requiring a larger aperture than originally anticipated. This setting is distinct from that which produces an on-axis spectrum similar to a single long undulator. Furthermore, partial coherence calculations, utilizing a multiple electron approach, indicate that a high degree of spatial coherence is still obtained at the sample location when such an aperture is used. The aperture size which maximizes the signal-to-noise ratio of a double-slit experiment is explored. This combination of high coherence and intensity is ideally suited for x-ray ptychography experiments which reconstruct the scattering density from micro-diffraction patterns. This technique is briefly reviewed and the effects on the image quality of proximity to the beamline focus are explored.

Atmospheric free-space coherent optical communications with adaptive optics

Science.gov (United States)

Ting, Chueh; Zhang, Chengyu; Yang, Zikai

2017-02-01

Free-space coherent optical communications have a potential application to offer last mile bottleneck solution in future local area networks (LAN) because of their information carrier, information security and license-free status. Coherent optical communication systems using orthogonal frequency division multiplexing (OFDM) digital modulation are successfully demonstrated in a long-haul tens Giga bits via optical fiber, but they are not yet available in free space due to atmospheric turbulence-induced channel fading. Adaptive optics is recognized as a promising technology to mitigate the effects of atmospheric turbulence in free-space optics. In this paper, a free-space coherent optical communication system using an OFDM digital modulation scheme and adaptive optics (FSO OFDM AO) is proposed, a Gamma-Gamma distribution statistical channel fading model for the FSO OFDM AO system is examined, and FSO OFDM AO system performance is evaluated in terms of bit error rate (BER) versus various propagation distances.

Using the phase-space imager to analyze partially coherent imaging systems: bright-field, phase contrast, differential interference contrast, differential phase contrast, and spiral phase contrast

Science.gov (United States)

Mehta, Shalin B.; Sheppard, Colin J. R.

2010-05-01

Various methods that use large illumination aperture (i.e. partially coherent illumination) have been developed for making transparent (i.e. phase) specimens visible. These methods were developed to provide qualitative contrast rather than quantitative measurement-coherent illumination has been relied upon for quantitative phase analysis. Partially coherent illumination has some important advantages over coherent illumination and can be used for measurement of the specimen's phase distribution. However, quantitative analysis and image computation in partially coherent systems have not been explored fully due to the lack of a general, physically insightful and computationally efficient model of image formation. We have developed a phase-space model that satisfies these requirements. In this paper, we employ this model (called the phase-space imager) to elucidate five different partially coherent systems mentioned in the title. We compute images of an optical fiber under these systems and verify some of them with experimental images. These results and simulated images of a general phase profile are used to compare the contrast and the resolution of the imaging systems. We show that, for quantitative phase imaging of a thin specimen with matched illumination, differential phase contrast offers linear transfer of specimen information to the image. We also show that the edge enhancement properties of spiral phase contrast are compromised significantly as the coherence of illumination is reduced. The results demonstrate that the phase-space imager model provides a useful framework for analysis, calibration, and design of partially coherent imaging methods.

Optical coherence tomography findings of quinine poisoning

Directory of Open Access Journals (Sweden)

John Christoforidis

2011-01-01

Full Text Available John Christoforidis, Robert Ricketts, Theodore Loizos, Susie ChangThe Ohio State University College of Medicine, Columbus, OH, USAPurpose: To report a case of acute quinine poisoning, document acute and chronic macular changes with optical coherence tomography imaging and fluorescein angiography (FA, and to review the literature on ocular toxicity of quinine.Methods: A 32-year-old white female presented to our Emergency Department after ingesting over 7.5 g of quinine. She underwent a complete ophthalmologic examination, fluorescein angiography, Stratus time-domain optical coherence tomography (OCT, and electroretinography at 72 hours and 15 months postingestion. Stratus time-domain and Cirrus spectral-domain OCT, fundus autofluorescence, and FA were obtained at 28 months postingestion.Results: Fluorescein angiography at 72 hours postingestion revealed normal filling times and vasculature. OCT showed marked thickening of the inner retina bilaterally. At 15 and 28 months follow-up, fundus photography and fluorescein angiography demonstrated optic nerve pallor, severely attenuated retinal vessels while OCT showed inner retinal atrophy. Fundus autofluorescence did not reveal any retinal pigmentary abnormalities.Conclusions: Quinine toxicity as seen by OCT reveals increased thickness with inner retinal hyperreflectivity acutely with development of significant retinal atrophy in the long-term. Fundus autofluorescence reveals an intact retinal pigment epithelial layer at 28 months. These findings suggest that quinine poisoning may produce a direct toxic effect on the inner retina in the acute phase resulting in long-term retinal atrophy.Keywords: retinal, optical coherence tomography, quinine toxicity 

Optical coherence tomography of dental structures

Science.gov (United States)

Baumgartner, Angela; Hitzenberger, Christoph K.; Dichtl, Sabine; Sattmann, Harald; Moritz, Andreas; Sperr, Wolfgang; Fercher, Adolf F.

1998-04-01

In the past ten years Partial Coherence Interferometry (PCI) and Optical Coherence Tomography (OCT) have been successfully developed for high precision biometry and tomography of biological tissues. OCT employs the partial coherence properties of a superluminescent diode and the Doppler principle yielding resolution and precision figures of the order of a few microns. Presently, the main application fields of this technique are biometry and imaging of ocular structures in vivo, as well as its clinical use in dermatology and endoscopic applications. This well established length measuring and imaging technique has now been applied to dentistry. First in vitro OCT images of the cemento (dentine) enamel junction of extracted sound and decayed human teeth have been recorded. These images distinguish dentine and enamel structures that are important for assessing enamel thickness and diagnosing caries. Individual optical A-Scans show that the penetration depth into enamel is considerably larger than into dentine. First polarization sensitive OCT recordings show localized changes of the polarization state of the light backscattered by dental material. Two-dimensional maps of the magnitude of the interference intensity and of the total phase difference between two orthogonal polarization states as a function of depth can reveal important structural information.

Optical Coherence Tomography of the Aging Kidney.

Science.gov (United States)

Andrews, Peter M; Wang, Hsing-Wen; Guo, Hengchang; Anderson, Erik; Falola, Reuben; Chen, Yu

2016-12-01

The aging kidney exhibits a progressive decline in renal function with characteristic histopathologic changes and is a risk factor for renal transplant. However, the degree to which the kidney exhibits this decline depends on several factors that vary from one individual to the next. Optical coherence tomography is an evolving noninvasive imaging technology that has recently been used to evaluate acute tubular necrosis of living-human donor kidneys before their transplant. With the increasing use of kidneys from older individuals, it is important to determine whether optical coherence tomography also can distinguish the histopathology associated with aging. In this investigation, we used Munich-Wistar rats to evaluate the ability of optical coherence tomography to detect histopathologic changes associated with aging. Optical coherence tomography observations were correlated with renal function and conventional light microscopic evaluation of these same kidneys. With the onset of severe proteinuria at 10 to 12 months of age, optical coherence tomography revealed tubular necrosis/atrophy, interstitial fibrosis, tubular dilation, and glomerulosclerosis. With a further deterioration in kidney function at 16 to 18 months of age (as indicated by rising creatinine levels), optical coherence tomography revealed more extensive interstitial fibrosis and tubular atrophy, increased tubular dilation with cyst formation and more sclerotic glomeruli. The foregoing observations suggest that optical coherence tomography can be used to detect the histopathology of progressive nephropathy associated with aging.

Label-free imaging of developing vasculature in zebrafish with phase variance optical coherence microscopy

Science.gov (United States)

Chen, Yu; Fingler, Jeff; Trinh, Le A.; Fraser, Scott E.

2016-03-01

A phase variance optical coherence microscope (pvOCM) has been created to visualize blood flow in the vasculature of zebrafish embryos, without using exogenous labels. The pvOCM imaging system has axial and lateral resolutions of 2 μm in tissue, and imaging depth of more than 100 μm. Imaging of 2-5 days post-fertilization zebrafish embryos identified the detailed structures of somites, spinal cord, gut and notochord based on intensity contrast. Visualization of the blood flow in the aorta, veins and intersegmental vessels was achieved with phase variance contrast. The pvOCM vasculature images were confirmed with corresponding fluorescence microscopy of a zebrafish transgene that labels the vasculature with green fluorescent protein. The pvOCM images also revealed functional information of the blood flow activities that is crucial for the study of vascular development.

Equalization Enhanced Phase Noise in Coherent Optical Systems with Digital Pre- and Post-Processing

Directory of Open Access Journals (Sweden)

Aditya Kakkar

2016-03-01

Full Text Available We present an extensive study of equalization enhanced phase noise (EEPN in coherent optical system for all practical electronic dispersion compensation configurations. It is shown that there are only eight practicable all-electronic impairment mitigation configurations. The non-linear and time variant analysis reveals that the existence and the cause of EEPN depend on the digital signal processing (DSP schemes. There are three schemes that in principle do not cause EEPN. Analysis further reveals the statistical equivalence of the remaining five system configurations resulting in EEPN. In three of them, EEPN is due to phase noise of the transmitting laser, while in the remaining two, EEPN is caused by the local oscillator. We provide a simple look-up table for the system designer to make an informative decision regarding practicable configuration choice and design.

Advanced Optical Technologies for Defense Trauma and Critical Care

Science.gov (United States)

2014-02-04

Imaging and quantifying Brownian motion of micro- and nanoparticles using phase resolved Doppler variance optical coherence tomography,” J. of...Optical traps can stop movements of Mesostoma spermatocyte kinetochores. Am. Soc. Cell Biol. Mtg., Denver, CO, December 3-7, 2011. 22 8. Gioux, S

On the performance of joint iterative detection and decoding in coherent optical channels with laser frequency fluctuations

Science.gov (United States)

Castrillón, Mario A.; Morero, Damián A.; Agazzi, Oscar E.; Hueda, Mario R.

2015-08-01

The joint iterative detection and decoding (JIDD) technique has been proposed by Barbieri et al. (2007) with the objective of compensating the time-varying phase noise and constant frequency offset experienced in satellite communication systems. The application of JIDD to optical coherent receivers in the presence of laser frequency fluctuations has not been reported in prior literature. Laser frequency fluctuations are caused by mechanical vibrations, power supply noise, and other mechanisms. They significantly degrade the performance of the carrier phase estimator in high-speed intradyne coherent optical receivers. This work investigates the performance of the JIDD algorithm in multi-gigabit optical coherent receivers. We present simulation results of bit error rate (BER) for non-differential polarization division multiplexing (PDM)-16QAM modulation in a 200 Gb/s coherent optical system that includes an LDPC code with 20% overhead and net coding gain of 11.3 dB at BER = 10-15. Our study shows that JIDD with a pilot rate ⩽ 5 % compensates for both laser phase noise and laser frequency fluctuation. Furthermore, since JIDD is used with non-differential modulation formats, we find that gains in excess of 1 dB can be achieved over existing solutions based on an explicit carrier phase estimator with differential modulation. The impact of the fiber nonlinearities in dense wavelength division multiplexing (DWDM) systems is also investigated. Our results demonstrate that JIDD is an excellent candidate for application in next generation high-speed optical coherent receivers.

Digital processing optical transmission and coherent receiving techniques

CERN Document Server

Binh, Le Nguyen

2013-01-01

With coherent mixing in the optical domain and processing in the digital domain, advanced receiving techniques employing ultra-high speed sampling rates have progressed tremendously over the last few years. These advances have brought coherent reception systems for lightwave-carried information to the next stage, resulting in ultra-high capacity global internetworking. Digital Processing: Optical Transmission and Coherent Receiving Techniques describes modern coherent receiving techniques for optical transmission and aspects of modern digital optical communications in the most basic lines. The

Modulating the amplitude and phase of the complex spectral degree of coherence with plasmonic interferometry

Science.gov (United States)

Li, Dongfang; Pacifici, Domenico

The spectral degree of coherence describes the correlation of electromagnetic fields, which plays a key role in many applications, including free-space optical communications and speckle-free bioimaging. Recently, plasmonic interferometry, i.e. optical interferometry that employs surface plasmon polaritons (SPPs), has enabled enhanced light transmission and high-sensitivity biosensing, among other applications. It offers new ways to characterize and engineer electromagnetic fields using nano-structured thin metal films. Here, we employ plasmonic interferometry to demonstrate full control of spatial coherence at length scales comparable to the wavelength of the incident light. Specifically, by measuring the diffraction pattern of several double-slit plasmonic structures etched on a metal film, the amplitude and phase of the degree of spatial coherence is determined as a function of slit-slit separation distance and incident wavelength. When the SPP contribution is turned on (i.e., by changing the polarization of the incident light from TE to TM illumination mode), strong modulation of both amplitude and phase of the spatial coherence is observed. These findings may help design compact modulators of optical spatial coherence and other optical elements to shape the light intensity in the far-field.

Coherent feedback control of multipartite quantum entanglement for optical fields

Energy Technology Data Exchange (ETDEWEB)

Yan, Zhihui; Jia, Xiaojun; Xie, Changde; Peng, Kunchi [State Key Laboratory of Quantum Optics and Quantum Optics Devices, Institute of Opto-Electronics, Shanxi University, Taiyuan, 030006 (China)

2011-12-15

Coherent feedback control (CFC) of multipartite optical entangled states produced by a nondegenerate optical parametric amplifier is theoretically studied. The features of the quantum correlations of amplitude and phase quadratures among more than two entangled optical modes can be controlled by tuning the transmissivity of the optical beam splitter in the CFC loop. The physical conditions to enhance continuous variable multipartite entanglement of optical fields utilizing the CFC loop are obtained. The numeric calculations based on feasible physical parameters of realistic systems provide direct references for the design of experimental devices.

Nonadiabatic Dynamics May Be Probed through Electronic Coherence in Time-Resolved Photoelectron Spectroscopy.

Science.gov (United States)

Bennett, Kochise; Kowalewski, Markus; Mukamel, Shaul

2016-02-09

We present a hierarchy of Fermi golden rules (FGRs) that incorporate strongly coupled electronic/nuclear dynamics in time-resolved photoelectron spectroscopy (TRPES) signals at different levels of theory. Expansion in the joint electronic and nuclear eigenbasis yields the numerically most challenging exact FGR (eFGR). The quasistatic Fermi Golden Rule (qsFGR) neglects nuclear motion during the photoionization process but takes into account electronic coherences as well as populations initially present in the pumped matter as well as those generated internally by coupling between electronic surfaces. The standard semiclassical Fermi Golden Rule (scFGR) neglects the electronic coherences and the nuclear kinetic energy during the ionizing pulse altogether, yielding the classical Condon approximation. The coherence contributions depend on the phase-profile of the ionizing field, allowing coherent control of TRPES signals. The photoelectron spectrum from model systems is simulated using these three levels of theory. The eFGR and the qsFGR show temporal oscillations originating from the electronic or vibrational coherences generated as the nuclear wave packet traverses a conical intersection. These oscillations, which are missed by the scFGR, directly reveal the time-evolving splitting between electronic states of the neutral molecule in the curve-crossing regime.

X-ray diffraction and imaging with a coherent beam: application to X-ray optical elements and to crystals exhibiting phase inhomogeneities

International Nuclear Information System (INIS)

Masiello, F.

2011-05-01

The exceptional properties of synchrotron light sources have been exploited in very different disciplines, from archaeology to chemistry, from material science to biology, from medicine to physics. Among these properties it is important to mention the high brilliance, continuum spectrum, high degree of polarization, time structure, small source size and divergence of the beam, the last resulting in a high transversal coherence of the produced radiation. This high transversal coherence of the synchrotron sources has permitted the development of new techniques, e.g. phase contrast imaging, X-ray photon correlation spectroscopy and coherent X-ray diffraction imaging (CXDI). This thesis work will consist essentially of three parts. In the first part it will be presented the work done as a member of the X-ray Optics Group of ESRF in the characterization of high quality diamond crystals foreseen as X-ray optical elements. The characterization has been done using different complementary X-ray techniques, such as high resolution diffraction, topography, grazing incidence diffraction, reflectivity and measurements of the coherence preservation using the Talbot effect. In the second part, I will show the result obtained in the study of the temperature behaviours of the domain in periodically poled ferroelectrics crystals. This type of measurements, based on Bragg-Fresnel diffraction, are possible only thanks to the high degree of coherence of the beam. In the third part, I will present the results obtained in the characterization of diamonds foreseen for applications other than X-ray optical elements. (author)

Transient Evolutional Dynamics of Quantum-Dot Molecular Phase Coherence for Sensitive Optical Switching

Science.gov (United States)

Shen, Jian Qi; Gu, Jing

2018-04-01

Atomic phase coherence (quantum interference) in a multilevel atomic gas exhibits a number of interesting phenomena. Such an atomic quantum coherence effect can be generalized to a quantum-dot molecular dielectric. Two quantum dots form a quantum-dot molecule, which can be described by a three-level Λ-configuration model { |0> ,|1> ,|2> } , i.e., the ground state of the molecule is the lower level |0> and the highly degenerate electronic states in the two quantum dots are the two upper levels |1> ,|2> . The electromagnetic characteristics due to the |0>-|1> transition can be controllably manipulated by a tunable gate voltage (control field) that drives the |2>-|1> transition. When the gate voltage is switched on, the quantum-dot molecular state can evolve from one steady state (i.e., |0>-|1> two-level dressed state) to another steady state (i.e., three-level coherent-population-trapping state). In this process, the electromagnetic characteristics of a quantum-dot molecular dielectric, which is modified by the gate voltage, will also evolve. In this study, the transient evolutional behavior of the susceptibility of a quantum-dot molecular thin film and its reflection spectrum are treated by using the density matrix formulation of the multilevel systems. The present field-tunable and frequency-sensitive electromagnetic characteristics of a quantum-dot molecular thin film, which are sensitive to the applied gate voltage, can be utilized to design optical switching devices.

Multi-kW coherent combining of fiber lasers seeded with pseudo random phase modulated light

Science.gov (United States)

Flores, Angel; Ehrehreich, Thomas; Holten, Roger; Anderson, Brian; Dajani, Iyad

2016-03-01

We report efficient coherent beam combining of five kilowatt-class fiber amplifiers with a diffractive optical element (DOE). Based on a master oscillator power amplifier (MOPA) configuration, the amplifiers were seeded with pseudo random phase modulated light. Each non-polarization maintaining fiber amplifier was optically path length matched and provides approximately 1.2 kW of near diffraction-limited output power (measured M2polarization control. A low power sample of the combined beam after the DOE provided an error signal for active phase locking which was performed via Locking of Optical Coherence by Single-Detector Electronic-Frequency Tagging (LOCSET). After phase stabilization, the beams were coherently combined via the 1x5 DOE. A total combined output power of 4.9 kW was achieved with 82% combining efficiency and excellent beam quality (M2splitter loss was 5%. Similarly, losses due in part to non-ideal polarization, ASE content, uncorrelated wavefront errors, and misalignment errors contributed to the efficiency reduction.

Active control on high-order coherence and statistic characterization on random phase fluctuation of two classical point sources.

Science.gov (United States)

Hong, Peilong; Li, Liming; Liu, Jianji; Zhang, Guoquan

2016-03-29

Young's double-slit or two-beam interference is of fundamental importance to understand various interference effects, in which the stationary phase difference between two beams plays the key role in the first-order coherence. Different from the case of first-order coherence, in the high-order optical coherence the statistic behavior of the optical phase will play the key role. In this article, by employing a fundamental interfering configuration with two classical point sources, we showed that the high- order optical coherence between two classical point sources can be actively designed by controlling the statistic behavior of the relative phase difference between two point sources. Synchronous position Nth-order subwavelength interference with an effective wavelength of λ/M was demonstrated, in which λ is the wavelength of point sources and M is an integer not larger than N. Interestingly, we found that the synchronous position Nth-order interference fringe fingerprints the statistic trace of random phase fluctuation of two classical point sources, therefore, it provides an effective way to characterize the statistic properties of phase fluctuation for incoherent light sources.

Dental optical coherence domain reflectometry explorer

Energy Technology Data Exchange (ETDEWEB)

Everett, Matthew J. (Livermore, CA); Colston, Jr., Billy W. (Livermore, CA); Sathyam, Ujwal S. (Livermore, CA); Da Silva, Luiz B. (Pleasanton, CA)

2001-01-01

A hand-held, fiber optic based dental device with optical coherence domain reflectometry (OCDR) sensing capabilities provides a profile of optical scattering as a function of depth in the tissue at the point where the tip of the dental explorer touches the tissue. This system provides information on the internal structure of the dental tissue, which is then used to detect caries and periodontal disease. A series of profiles of optical scattering or tissue microstructure are generated by moving the explorer across the tooth or other tissue. The profiles are combined to form a cross-sectional, or optical coherence tomography (OCT), image.

Coherence enhanced quantum metrology in a nonequilibrium optical molecule

Science.gov (United States)

Wang, Zhihai; Wu, Wei; Cui, Guodong; Wang, Jin

2018-03-01

We explore the quantum metrology in an optical molecular system coupled to two environments with different temperatures, using a quantum master equation beyond secular approximation. We discover that the steady-state coherence originating from and sustained by the nonequilibrium condition can enhance quantum metrology. We also study the quantitative measures of the nonequilibrium condition in terms of the curl flux, heat current and entropy production at the steady state. They are found to grow with temperature difference. However, an apparent paradox arises considering the contrary behaviors of the steady-state coherence and the nonequilibrium measures in relation to the inter-cavity coupling strength. This paradox is resolved by decomposing the heat current into a population part and a coherence part. Only the latter, the coherence part of the heat current, is tightly connected to the steady-state coherence and behaves similarly with respect to the inter-cavity coupling strength. Interestingly, the coherence part of the heat current flows from the low-temperature reservoir to the high-temperature reservoir, opposite to the direction of the population heat current. Our work offers a viable way to enhance quantum metrology for open quantum systems through steady-state coherence sustained by the nonequilibrium condition, which can be controlled and manipulated to maximize its utility. The potential applications go beyond quantum metrology and extend to areas such as device designing, quantum computation and quantum technology in general.

Strategies to improve phase-stability of ultrafast swept source optical coherence tomography for single shot imaging of transient mechanical waves at 16 kHz frame rate

Energy Technology Data Exchange (ETDEWEB)

Song, Shaozhen; Wei, Wei; Hsieh, Bao-Yu; Pelivanov, Ivan; O' Donnell, Matthew [Department of Bioengineering, University of Washington, Seattle, Washington 98195 (United States); Shen, Tueng T.; Wang, Ruikang K., E-mail: wangrk@uw.edu [Department of Bioengineering, University of Washington, Seattle, Washington 98195 (United States); Department of Ophthalmology, University of Washington, Seattle, Washington 98104 (United States)

2016-05-09

We present single-shot phase-sensitive imaging of propagating mechanical waves within tissue, enabled by an ultrafast optical coherence tomography (OCT) system powered by a 1.628 MHz Fourier domain mode-locked (FDML) swept laser source. We propose a practical strategy for phase-sensitive measurement by comparing the phases between adjacent OCT B-scans, where the B-scan contains a number of A-scans equaling an integer number of FDML buffers. With this approach, we show that micro-strain fields can be mapped with ∼3.0 nm sensitivity at ∼16 000 fps. The system's capabilities are demonstrated on porcine cornea by imaging mechanical wave propagation launched by a pulsed UV laser beam, promising non-contact, real-time, and high-resolution optical coherence elastography.

Spatially-resolved in-situ quantification of biofouling using optical coherence tomography (OCT) and 3D image analysis in a spacer filled channel

KAUST Repository

Fortunato, Luca

2016-11-21

The use of optical coherence tomography (OCT) to investigate biomass in membrane systems has increased with time. OCT is able to characterize the biomass in-situ and non-destructively. In this study, a novel approach to process three-dimensional (3D) OCT scans is proposed. The approach allows obtaining spatially-resolved detailed structural biomass information. The 3D biomass reconstruction enables analysis of the biomass only, obtained by subtracting the time zero scan to all images. A 3D time series analysis of biomass development in a spacer filled channel under representative conditions (cross flow velocity) for a spiral wound membrane element was performed. The flow cell was operated for five days with monitoring of ultrafiltration membrane performance: feed channel pressure drop and permeate flux. The biomass development in the flow cell was detected by OCT before a performance decline was observed. Feed channel pressure drop continuously increased with increasing biomass volume, while flux decline was mainly affected in the initial phase of biomass accumulation. The novel OCT imaging approach enabled the assessment of spatial biomass distribution in the flow cell, discriminating the total biomass volume between the membrane, feed spacer and glass window. Biomass accumulation was stronger on the feed spacer during the early stage of biofouling, impacting the feed channel pressure drop stronger than permeate flux.

Numerical modeling of optical coherent transient processes with complex configurations - II. Angled beams with arbitrary phase modulations

International Nuclear Information System (INIS)

Chang Tiejun; Tian Mingzhen; Barber, Zeb W.; Randall Babbitt, Wm.

2004-01-01

This work is a continuation of the development of the theoretical model for optical coherent transient (OCT) processes with complex configurations. A theoretical model for angled beams with arbitrary phase modulation has been developed based on the model presented in our previous work for the angled beam geometry. A numerical tool has been devised to simulate the OCT processes involving angled beams with the frequency detuning, chirped, and phase-modulated laser pulses. The simulations for pulse shaping and arbitrary waveform generation (AWG) using OCT processes have been performed. The theoretical analysis of programming and probe schemes for pulse shaper and AWG is also presented including the discussions on the rephasing condition and the phase compensation. The results from the analysis, the simulation, and the experiment show very good agreement

Online monitoring of printed electronics by Spectral-Domain Optical Coherence Tomography

KAUST Repository

Alarousu, Erkki

2013-03-28

Spectral-Domain Optical Coherence Tomography (SD-OCT) is an optical method capable of 3D imaging of object\\'s internal structure with micron-scale resolution. Modern SD-OCT tools offer the speed capable of online monitoring of printed devices. This paper demonstrates the use of SD-OCT in a simulated roll-to-roll (R2R) process through monitoring some structural properties of moving screen printed interdigitated electrodes. It is shown that structural properties can be resolved for speeds up to ca. 1m/min, which is the first step towards application of this method in real manufacturing processes, including roll-to-roll (R2R) printing.

Extended depth of focus adaptive optics spectral domain optical coherence tomography

Science.gov (United States)

Sasaki, Kazuhiro; Kurokawa, Kazuhiro; Makita, Shuichi; Yasuno, Yoshiaki

2012-01-01

We present an adaptive optics spectral domain optical coherence tomography (AO-SDOCT) with a long focal range by active phase modulation of the pupil. A long focal range is achieved by introducing AO-controlled third-order spherical aberration (SA). The property of SA and its effects on focal range are investigated in detail using the Huygens-Fresnel principle, beam profile measurement and OCT imaging of a phantom. The results indicate that the focal range is extended by applying SA, and the direction of extension can be controlled by the sign of applied SA. Finally, we demonstrated in vivo human retinal imaging by altering the applied SA. PMID:23082278

Tuned Optical Front-End MMIC Amplifiers for a Coherent Optical Receiver

DEFF Research Database (Denmark)

Petersen, Anders Kongstad; Jagd, A M

1992-01-01

Two low noise tuned optical front-end GaAs MESFET MMIC amplifiers for a coherent optical CPFSK (Continuous Phase Frequency Shift Keying) receiver are presented. The receiver operates at 2.5 Gbit/s at an IF of approx. 9 GHz. The front-ends are based on full-custom designed MMICs and a commercially...... available GaInAs/InP pin photo diode. The procedure for measuring the transimpedance and the equivalent input noise current density is outlined in this paper and demonstrated using one of the MMICs. The MMICs were fabricated using the Plessey F20 process by GEC-Marconi through the ESPRIT programme EUROCHIP...

Nanosecond retinal structure changes in K-590 during the room-temperature bacteriorhodopsin photocycle: picosecond time-resolved coherent anti-stokes Raman spectroscopy

OpenAIRE

Weidlich, O.; Ujj, L.; Jäger, F.; Atkinson, G.H.

1997-01-01

Time-resolved vibrational spectra are used to elucidate the structural changes in the retinal chromophore within the K-590 intermediate that precedes the formation of the L-550 intermediate in the room-temperature (RT) bacteriorhodopsin (BR) photocycle. Measured by picosecond time-resolved coherent anti-Stokes Raman scattering (PTR/CARS), these vibrational data are recorded within the 750 cm-1 to 1720 cm-1 spectral region and with time delays of 50-260 ns after the RT/BR photocycle is optical...

Challenges in Scale-Resolving Simulations of turbulent wake flows with coherent structures

Science.gov (United States)

Pereira, Filipe S.; Eça, Luís; Vaz, Guilherme; Girimaji, Sharath S.

2018-06-01

The objective of this work is to investigate the challenges encountered in Scale-Resolving Simulations (SRS) of turbulent wake flows driven by spatially-developing coherent structures. SRS of practical interest are expressly intended for efficiently computing such flows by resolving only the most important features of the coherent structures and modelling the remainder as stochastic field. The success of SRS methods depends upon three important factors: i) ability to identify key flow mechanisms responsible for the generation of coherent structures; ii) determine the optimum range of resolution required to adequately capture key elements of coherent structures; and iii) ensure that the modelled part is comprised nearly exclusively of fully-developed stochastic turbulence. This study considers the canonical case of the flow around a circular cylinder to address the aforementioned three key issues. It is first demonstrated using experimental evidence that the vortex-shedding instability and flow-structure development involves four important stages. A series of SRS computations of progressively increasing resolution (decreasing cut-off length) are performed. An a priori basis for locating the origin of the coherent structures development is proposed and examined. The criterion is based on the fact that the coherent structures are generated by the Kelvin-Helmholtz (KH) instability. The most important finding is that the key aspects of coherent structures can be resolved only if the effective computational Reynolds number (based on total viscosity) exceeds the critical value of the KH instability in laminar flows. Finally, a quantitative criterion assessing the nature of the unresolved field based on the strain-rate ratio of mean and unresolved fields is examined. The two proposed conditions and rationale offer a quantitative basis for developing "good practice" guidelines for SRS of complex turbulent wake flows with coherent structures.

Contribution to coherent atom optics - Design of multiple wave devices

International Nuclear Information System (INIS)

Impens, F.

2008-03-01

The theoretical work presented in this manuscript addresses two complementary issues in coherent atom optics. The first part addresses the perspectives offered by coherent atomic sources through the design of two experiment involving the levitation of a cold atomic sample in a periodic series of light pulses, and for which coherent atomic clouds are particularly well-suited. These systems appear as multiple wave atom interferometers. A striking feature of these experiments is that a unique system performs both the sample trapping and interrogation. To obtain a transverse confinement, a novel atomic lens is proposed, relying on the interaction between an atomic wave with a spherical light wave. The sensitivity of the sample trapping towards the gravitational acceleration and towards the pulse frequencies is exploited to perform the desired measurement. These devices constitute atomic wave resonators in momentum space, which is a novel concept in atom optics. A second part develops new theoretical tools - most of which inspired from optics - well-suited to describe the propagation of coherent atomic sources. A phase-space approach of the propagation, relying on the evolution of moments, is developed and applied to study the low-energy dynamics of Bose-Einstein condensates. The ABCD method of propagation for atomic waves is extended beyond the linear regime to account perturbatively for mean-field atomic interactions in the atom-optical aberration-less approximation. A treatment of the atom laser extraction enabling one to describe aberrations in the atomic beam, developed in collaboration with the Atom Optics group at the Institute of Optics, is exposed. Last, a quality factor suitable for the characterization of diluted matter waves in a general propagation regime has been proposed. (author)

Dimensioning BCH codes for coherent DQPSK systems with laser phase noise and cycle slips

DEFF Research Database (Denmark)

Leong, Miu Yoong; Larsen, Knud J.; Jacobsen, Gunnar

2014-01-01

Forward error correction (FEC) plays a vital role in coherent optical systems employing multi-level modulation. However, much of coding theory assumes that additive white Gaussian noise (AWGN) is dominant, whereas coherent optical systems have significant phase noise (PN) in addition to AWGN...... approach for a target post-FEC BER of 10-5. Codes dimensioned with our bivariate binomial model meet the target within 0.2-dB signal-to-noise ratio....

Magneto-motive detection of tissue-based macrophages by differential phase optical coherence tomography.

Science.gov (United States)

Oh, Junghwan; Feldman, Marc D; Kim, Jihoon; Kang, Hyun Wook; Sanghi, Pramod; Milner, Thomas E

2007-03-01

A novel method to detect tissue-based macrophages using a combination of superparamagnetic iron oxide (SPIO) nanoparticles and differential phase optical coherence tomography (DP-OCT) with an external oscillating magnetic field is reported. Magnetic force acting on iron-laden tissue-based macrophages was varied by applying a sinusoidal current to a solenoid containing a conical iron core that substantially focused and increased magnetic flux density. Nanoparticle motion was detected with DP-OCT, which can detect tissue movement with nanometer resolution. Frequency response of iron-laden tissue movement was twice the modulation frequency since the magnetic force is proportional to the product of magnetic flux density and gradient. Results of our experiments indicate that DP-OCT can be used to identify tissue-based macrophage when excited by an external focused oscillating magnetic field. (c) 2007 Wiley-Liss, Inc

Phase-controlled localization and directed transport in an optical bipartite lattice.

Science.gov (United States)

Hai, Kuo; Luo, Yunrong; Lu, Gengbiao; Hai, Wenhua

2014-02-24

We investigate coherent control of a single atom interacting with an optical bipartite lattice via a combined high-frequency modulation. Our analytical results show that the quantum tunneling and dynamical localization can depend on phase difference between the modulation components, which leads to a different route for the coherent destruction of tunneling and a convenient phase-control method for stabilizing the system to implement the directed transport of atom. The similar directed transport and the phase-controlled quantum transition are revealed for the corresponding many-particle system. The results can be referable for experimentally manipulating quantum transport and transition of cold atoms in the tilted and shaken optical bipartite lattice or of analogical optical two-mode quantum beam splitter, and also can be extended to other optical and solid-state systems.

Optical Coherence Tomography

DEFF Research Database (Denmark)

Fercher, A.F.; Andersen, Peter E.

2017-01-01

Optical coherence tomography (OCT) is a technique that is used to peer inside a body noninvasively. Tissue structure defined by tissue absorption and scattering coefficients, and the speed of blood flow, are derived from the characteristics of light remitted by the body. Singly backscattered light...... detected by partial coherence interferometry (PCI) is used to synthesize the tomographic image coded in false colors. A prerequisite of this technique is a low time-coherent but high space-coherent light source, for example, a superluminescent diode or a supercontinuum source. Alternatively, the imaging...... technique can be realized by using ultrafast wavelength scanning light sources. For tissue imaging, the light source wavelengths are restricted to the red and near-infrared (NIR) region from about 600 to 1300 nm, the so-called therapeutic window, where absorption (μa ≈ 0.01 mm−1) is small enough. Transverse...

Propagation of coherent light pulses with PHASE

Science.gov (United States)

Bahrdt, J.; Flechsig, U.; Grizzoli, W.; Siewert, F.

2014-09-01

The current status of the software package PHASE for the propagation of coherent light pulses along a synchrotron radiation beamline is presented. PHASE is based on an asymptotic expansion of the Fresnel-Kirchhoff integral (stationary phase approximation) which is usually truncated at the 2nd order. The limits of this approximation as well as possible extensions to higher orders are discussed. The accuracy is benchmarked against a direct integration of the Fresnel-Kirchhoff integral. Long range slope errors of optical elements can be included by means of 8th order polynomials in the optical element coordinates w and l. Only recently, a method for the description of short range slope errors has been implemented. The accuracy of this method is evaluated and examples for realistic slope errors are given. PHASE can be run either from a built-in graphical user interface or from any script language. The latter method provides substantial flexibility. Optical elements including apertures can be combined. Complete wave packages can be propagated, as well. Fourier propagators are included in the package, thus, the user may choose between a variety of propagators. Several means to speed up the computation time were tested - among them are the parallelization in a multi core environment and the parallelization on a cluster.

Parametric imaging of viscoelasticity using optical coherence elastography

Science.gov (United States)

Wijesinghe, Philip; McLaughlin, Robert A.; Sampson, David D.; Kennedy, Brendan F.

2015-03-01

We demonstrate imaging of soft tissue viscoelasticity using optical coherence elastography. Viscoelastic creep deformation is induced in tissue using step-like compressive loading and the resulting time-varying deformation is measured using phase-sensitive optical coherence tomography. From a series of co-located B-scans, we estimate the local strain rate as a function of time, and parameterize it using a four-parameter Kelvin-Voigt model of viscoelastic creep. The estimated viscoelastic strain and time constant are used to visualize viscoelastic creep in 2D, dual-parameter viscoelastograms. We demonstrate our technique on six silicone tissue-simulating phantoms spanning a range of viscoelastic parameters. As an example in soft tissue, we report viscoelastic contrast between muscle and connective tissue in fresh, ex vivo rat gastrocnemius muscle and mouse abdominal transection. Imaging viscoelastic creep deformation has the potential to provide complementary contrast to existing imaging modalities, and may provide greater insight into disease pathology.

Determination of the depth-resolved Stokes parameters of light backscattered from turbid media by use of polarization-sensitive optical coherence tomography

International Nuclear Information System (INIS)

Boer, J.F. de; Milner, T.E.; Nelson, J.S.

1999-01-01

Polarization-sensitive optical coherence tomography (PS-OCT) was used to characterize completely the polarization state of light backscattered from turbid media. Using a low-coherence light source, one can determine the Stokes parameters of backscattered light as a function of optical path in turbid media. To demonstrate the application of this technique we determined the birefringence and the optical axis in fibrous tissue (rodent muscle) and in vivo rodent skin. PS-OCT has potentially useful applications in biomedical optics by imaging simultaneously the structural properties of turbid biological materials and their effects on the polarization state of backscattered light. This method may also find applications in material science for investigation of polarization properties (e.g., birefringence) in opaque media such as ceramics and crystals. copyright 1999 Optical Society of America

Ultrafast optical responses of {beta}-carotene and lycopene probed by sub-20-fs time-resolved coherent spectroscopy

Energy Technology Data Exchange (ETDEWEB)

Fujiwara, M.; Sugisaki, M. [CREST-JST and Department of Physics, Osaka City University, Osaka 558-8585 (Japan); Gall, A.; Robert, B. [CEA, Institut de Biologie et Technologies de Saclay, and CNRS, Gif-sur-Yvette F-91191 (France); Cogdell, R.J. [IBLS, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8QQ, Scotland (United Kingdom); Hashimoto, H., E-mail: hassy@sci.osaka-cu.ac.j [CREST-JST and Department of Physics, Osaka City University, Osaka 558-8585 (Japan)

2009-12-15

We investigate how structural distortions in carotenoid cause decoherences of its high-frequency vibrational modes by applying the sub-20-fs time-resolved transient grating spectroscopy to {beta}-carotene and lycopene. The results indicate that the C=C central stretching mode shows significant loss of coherence under the effects of the steric hindrance between {beta}-ionone ring and polyene backbone, whereas the other high-frequency modes do not show such dependency on the structural distortions.

Ultrafast optical responses of β-carotene and lycopene probed by sub-20-fs time-resolved coherent spectroscopy

International Nuclear Information System (INIS)

Fujiwara, M.; Sugisaki, M.; Gall, A.; Robert, B.; Cogdell, R.J.; Hashimoto, H.

2009-01-01

We investigate how structural distortions in carotenoid cause decoherences of its high-frequency vibrational modes by applying the sub-20-fs time-resolved transient grating spectroscopy to β-carotene and lycopene. The results indicate that the C=C central stretching mode shows significant loss of coherence under the effects of the steric hindrance between β-ionone ring and polyene backbone, whereas the other high-frequency modes do not show such dependency on the structural distortions.

Multiple Scattering Model for Optical Coherence Tomography with Rytov Approximation

KAUST Repository

Li, Muxingzi

2017-04-24

Optical Coherence Tomography (OCT) is a coherence-gated, micrometer-resolution imaging technique that focuses a broadband near-infrared laser beam to penetrate into optical scattering media, e.g. biological tissues. The OCT resolution is split into two parts, with the axial resolution defined by half the coherence length, and the depth-dependent lateral resolution determined by the beam geometry, which is well described by a Gaussian beam model. The depth dependence of lateral resolution directly results in the defocusing effect outside the confocal region and restricts current OCT probes to small numerical aperture (NA) at the expense of lateral resolution near the focus. Another limitation on OCT development is the presence of a mixture of speckles due to multiple scatterers within the coherence length, and other random noise. Motivated by the above two challenges, a multiple scattering model based on Rytov approximation and Gaussian beam optics is proposed for the OCT setup. Some previous papers have adopted the first Born approximation with the assumption of small perturbation of the incident field in inhomogeneous media. The Rytov method of the same order with smooth phase perturbation assumption benefits from a wider spatial range of validity. A deconvolution method for solving the inverse problem associated with the first Rytov approximation is developed, significantly reducing the defocusing effect through depth and therefore extending the feasible range of NA.

Theoretical calculation on ICI reduction using digital coherent superposition of optical OFDM subcarrier pairs in the presence of laser phase noise.

Science.gov (United States)

Yi, Xingwen; Xu, Bo; Zhang, Jing; Lin, Yun; Qiu, Kun

2014-12-15

Digital coherent superposition (DCS) of optical OFDM subcarrier pairs with Hermitian symmetry can reduce the inter-carrier-interference (ICI) noise resulted from phase noise. In this paper, we show two different implementations of DCS-OFDM that have the same performance in the presence of laser phase noise. We complete the theoretical calculation on ICI reduction by using the model of pure Wiener phase noise. By Taylor expansion of the ICI, we show that the ICI power is cancelled to the second order by DCS. The fourth order term is further derived out and only decided by the ratio of laser linewidth to OFDM subcarrier symbol rate, which can greatly simplify the system design. Finally, we verify our theoretical calculations in simulations and use the analytical results to predict the system performance. DCS-OFDM is expected to be beneficial to certain optical fiber transmissions.

Adaptive restoration of a partially coherent blurred image using an all-optical feedback interferometer with a liquid-crystal device.

Science.gov (United States)

Shirai, Tomohiro; Barnes, Thomas H

2002-02-01

A liquid-crystal adaptive optics system using all-optical feedback interferometry is applied to partially coherent imaging through a phase disturbance. A theoretical analysis based on the propagation of the cross-spectral density shows that the blurred image due to the phase disturbance can be restored, in principle, irrespective of the state of coherence of the light illuminating the object. Experimental verification of the theory has been performed for two cases when the object to be imaged is illuminated by spatially coherent light originating from a He-Ne laser and by spatially incoherent white light from a halogen lamp. We observed in both cases that images blurred by the phase disturbance were successfully restored, in agreement with the theory, immediately after the adaptive optics system was activated. The origin of the deviation of the experimental results from the theory, together with the effect of the feedback misalignment inherent in our optical arrangement, is also discussed.

The application of cost-effective lasers in coherent UDWDM-OFDM-PON aided by effective phase noise suppression methods.

Science.gov (United States)

Liu, Yue; Yang, Chuanchuan; Yang, Feng; Li, Hongbin

2014-03-24

Digital coherent passive optical network (PON), especially the coherent orthogonal frequency division multiplexing PON (OFDM-PON), is a strong candidate for the 2nd-stage-next-generation PON (NG-PON2). As is known, OFDM is very sensitive to the laser phase noise which severely limits the application of the cost-effective distributed feedback (DFB) lasers and more energy-efficient vertical cavity surface emitting lasers (VCSEL) in the coherent OFDM-PON. The current long-reach coherent OFDM-PON experiments always choose the expensive external cavity laser (ECL) as the optical source for its narrow linewidth (usuallyOFDM-PON and study the possibility of the application of the DFB lasers and VCSEL in coherent OFDM-PON. A typical long-reach coherent ultra dense wavelength division multiplexing (UDWDM) OFDM-PON has been set up. The numerical results prove that the OBE method can stand severe phase noise of the lasers in this architecture and the DFB lasers as well as VCSEL can be used in coherent OFDM-PON. In this paper, we have also analyzed the performance of the RF-pilot-aided (RFP) phase noise suppression method in coherent OFDM-PON.

Extracting subsurface fingerprints using optical coherence tomography

CSIR Research Space (South Africa)

Akhoury, SS

2015-02-01

Full Text Available Subsurface Fingerprints using Optical Coherence Tomography Sharat Saurabh Akhoury, Luke Nicholas Darlow Modelling and Digital Science, Council for Scientific and Industrial Research, Pretoria, South Africa Abstract Physiologists have found... approach to extract the subsurface fingerprint representation using a high-resolution imaging technology known as Optical Coherence Tomography (OCT). ...

Imaging granulomatous lesions with optical coherence tomography

DEFF Research Database (Denmark)

Banzhaf, Christina; Jemec, Gregor B E

2012-01-01

To investigate and compare the presentation of granulomatous lesions in optical coherence tomography (OCT) images and compare this to previous studies of nonmelanoma skin tumors.......To investigate and compare the presentation of granulomatous lesions in optical coherence tomography (OCT) images and compare this to previous studies of nonmelanoma skin tumors....

Holonomic Quantum Control by Coherent Optical Excitation in Diamond

Energy Technology Data Exchange (ETDEWEB)

Zhou, Brian B.; Jerger, Paul C.; Shkolnikov, V. O.; Heremans, F. Joseph; Burkard, Guido; Awschalom, David D.

2017-10-01

Although geometric phases in quantum evolution are historically overlooked, their active control now stimulates strategies for constructing robust quantum technologies. Here, we demonstrate arbitrary singlequbit holonomic gates from a single cycle of nonadiabatic evolution, eliminating the need to concatenate two separate cycles. Our method varies the amplitude, phase, and detuning of a two-tone optical field to control the non-Abelian geometric phase acquired by a nitrogen-vacancy center in diamond over a coherent excitation cycle. We demonstrate the enhanced robustness of detuned gates to excited-state decoherence and provide insights for optimizing fast holonomic control in dissipative quantum systems.

Holonomic Quantum Control by Coherent Optical Excitation in Diamond.

Science.gov (United States)

Zhou, Brian B; Jerger, Paul C; Shkolnikov, V O; Heremans, F Joseph; Burkard, Guido; Awschalom, David D

2017-10-06

Although geometric phases in quantum evolution are historically overlooked, their active control now stimulates strategies for constructing robust quantum technologies. Here, we demonstrate arbitrary single-qubit holonomic gates from a single cycle of nonadiabatic evolution, eliminating the need to concatenate two separate cycles. Our method varies the amplitude, phase, and detuning of a two-tone optical field to control the non-Abelian geometric phase acquired by a nitrogen-vacancy center in diamond over a coherent excitation cycle. We demonstrate the enhanced robustness of detuned gates to excited-state decoherence and provide insights for optimizing fast holonomic control in dissipative quantum systems.

Digital Signal Processing for Optical Coherent Communication Systems

DEFF Research Database (Denmark)

Zhang, Xu

spectrum narrowing tolerance 112-Gb/s DP-QPSK optical coherent systems using digital adaptive equalizer. The demonstrated results show that off-line DSP algorithms are able to reduce the bit error rate (BER) penalty induced by signal spectrum narrowing. Third, we also investigate bi...... wavelength division multiplex (U-DWDM) optical coherent systems based on 10-Gbaud QPSK. We report U-DWDM 1.2-Tb/s QPSK coherent system achieving spectral efficiency of 4.0-bit/s/Hz. In the experimental demonstration, digital decision feed back equalizer (DFE) algorithms and a finite impulse response (FIR......In this thesis, digital signal processing (DSP) algorithms are studied to compensate for physical layer impairments in optical fiber coherent communication systems. The physical layer impairments investigated in this thesis include optical fiber chromatic dispersion, polarization demultiplexing...

Spectrally resolved modal characteristics of leaky-wave-coupled quantum cascade phase-locked laser arrays

Science.gov (United States)

Sigler, Chris; Gibson, Ricky; Boyle, Colin; Kirch, Jeremy D.; Lindberg, Donald; Earles, Thomas; Botez, Dan; Mawst, Luke J.; Bedford, Robert

2018-01-01

The modal characteristics of nonresonant five-element phase-locked arrays of 4.7-μm emitting quantum cascade lasers (QCLs) have been studied using spectrally resolved near- and far-field measurements and correlated with results of device simulation. Devices are fabricated by a two-step metal-organic chemical vapor deposition process and operate predominantly in an in-phase array mode near threshold, although become multimode at higher drive levels. The wide spectral bandwidth of the QCL's core region is found to be a factor in promoting multispatial-mode operation at high drive levels above threshold. An optimized resonant-array design is identified to allow sole in-phase array-mode operation to high drive levels above threshold, and indicates that for phase-locked laser arrays full spatial coherence to high output powers does not require full temporal coherence.

Vortex phase-induced changes of the statistical properties of a partially coherent radially polarized beam.

Science.gov (United States)

Guo, Lina; Chen, Yahong; Liu, Xianlong; Liu, Lin; Cai, Yangjian

2016-06-27

Partially coherent radially polarized (PCRP) beam was introduced and generated in recent years. In this paper, we investigate the statistical properties of a PCRP beam embedded with a vortex phase (i.e., PCRP vortex beam). We derive the analytical formula for the cross-spectral density matrix of a PCRP vortex beam propagating through a paraxial ABCD optical system and analyze the statistical properties of a PCRP vortex beam focused by a thin lens. It is found that the statistical properties of a PCRP vortex beam on propagation are much different from those of a PCRP beam. The vortex phase induces not only the rotation of the beam spot, but also the changes of the beam shape, the degree of polarization and the state of polarization. We also find that the vortex phase plays a role of resisting the coherence-induced degradation of the intensity distribution and the coherence-induced depolarization. Furthermore, we report experimental generation of a PCRP vortex beam for the first time. Our results will be useful for trapping and rotating particles, free-space optical communications and detection of phase object.

Probing Photoinduced Structural Phase Transitions by Fast or Ultra-Fast Time-Resolved X-Ray Diffraction

Science.gov (United States)

Cailleau, Hervé Collet, Eric; Buron-Le Cointe, Marylise; Lemée-Cailleau, Marie-Hélène Koshihara, Shin-Ya

molecules transform in an independent way each other. Actually the photoinduced phase transition with the establishment of the new electronic and structural oscopic order is preceded by precursor co-operative phenomena due to the formation of nano-scale correlated objects. These are the counterpart of pre-transitional fluctuations at thermal equilibrium which take place above the transition temperature (short range order preceding long range one). Moreover ultra-fast X-ray scattering will play a central role within the fascinating field of manipulating coherence, for instance to directly observe coherent atomic motions induced by a light pulse, such as optical phonons. In the first part of this contribution we present what experimental features are accessible by X-ray scattering to describe the physical picture for a photoinduced structural phase transition. The second part shows how a time-resolved X-ray scattering experiment can be performed with regards to the different pulsed X-ray sources. The first time-resolved X-ray diffraction experiments on photoinduced phase transitions are described and discussed in the third part. Finally some challenges for future are briefly indicated in the conclusion.

Acoustical holographic recording with coherent optical read-out and image processing

Science.gov (United States)

Liu, H. K.

1980-10-01

New acoustic holographic wave memory devices have been designed for real-time in-situ recording applications. The basic operating principles of these devices and experimental results through the use of some of the prototypes of the devices are presented. Recording media used in the device include thermoplastic resin, Crisco vegetable oil, and Wilson corn oil. In addition, nonlinear coherent optical image processing techniques including equidensitometry, A-D conversion, and pseudo-color, all based on the new contact screen technique, are discussed with regard to the enhancement of the normally poor-resolved acoustical holographic images.

Bit-rate-transparent optical RZ-to-NRZ format conversion based on linear spectral phase filtering

DEFF Research Database (Denmark)

Maram, Reza; Da Ros, Francesco; Guan, Pengyu

2017-01-01

We propose a novel and strikingly simple design for all-optical bit-rate-transparent RZ-to-NRZ conversion based on optical phase filtering. The proposed concept is experimentally validated through format conversion of a 640 Gbit/s coherent RZ signal to NRZ signal.......We propose a novel and strikingly simple design for all-optical bit-rate-transparent RZ-to-NRZ conversion based on optical phase filtering. The proposed concept is experimentally validated through format conversion of a 640 Gbit/s coherent RZ signal to NRZ signal....

Autofluorescence and spectral-domain optical coherence tomography of optic disk melanocytoma.

Science.gov (United States)

Guerra, Ricardo Luz Leitão; Marback, Eduardo Ferrari; Silva, Igor Sandes Pessoa da; Maia Junior, Otacílio de Oliveira; Marback, Roberto Lorens

2014-01-01

The authors report fundus autofluorescence (FAF) and spectral-domain optical coherence tomography (OCT) findings of two consecutive patients who presented with optic disk melanocytoma (ODM). A retrospective study was performed by reviewing medical records and ophthalmic imaging examinations. Optical coherence tomography findings were sloped and brightly reflective anterior tumor surface, adjacent retinal desorganization and abrupt posterior optical shadowing. Vitreous seeds were found in one patient. Fundus autofluorescence revealed outstanding hypoautofluorescence at the tumor area and isoautofluorescence at the remaining retina. Optical coherence tomography findings of the reported cases are consistent with those reported in the reviewed literature. Fundus autofluorescence has been used in the assessment of choroidal melanocytic tumors, but not yet in melanocytomas. We assume that this is the first report of these findings and believe that when its pattern has become clearly defined, fundus autofluorescence will be a useful tool to avoid misdiagnosis in suspicious cases and for follow-up.

Autofluorescence and spectral-domain optical coherence tomography of optic disk melanocytoma

Directory of Open Access Journals (Sweden)

Ricardo Luz Leitão Guerra

2014-12-01

Full Text Available The authors report fundus autofluorescence (FAF and spectral-domain optical coherence tomography (OCT findings of two consecutive patients who presented with optic disk melanocytoma (ODM. A retrospective study was performed by reviewing medical records and ophthalmic imaging examinations. Optical coherence tomography findings were sloped and brightly reflective anterior tumor surface, adjacent retinal desorganization and abrupt posterior optical shadowing. Vitreous seeds were found in one patient. Fundus autofluorescence revealed outstanding hypoautofluorescence at the tumor area and isoautofluorescence at the remaining retina. Optical coherence tomography findings of the reported cases are consistent with those reported in the reviewed literature. Fundus autofluorescence has been used in the assessment of choroidal melanocytic tumors, but not yet in melanocytomas. We assume that this is the first report of these findings and believe that when its pattern has become clearly defined, fundus autofluorescence will be a useful tool to avoid misdiagnosis in suspicious cases and for follow-up.

640 Gbit/s RZ-to-NRZ format conversion based on optical phase filtering

DEFF Research Database (Denmark)

Maram, Reza; Kong, Deming; Galili, Michael

2014-01-01

We propose a novel approach for all optical RZ-to-NRZ conversion based on optical phase filtering. The proposed concept is experimentally validated through format conversion of a 640 Gbit/s coherent RZ signal to NRZ signal using a simple phase filter implemented by a commercial optical waveshaper....

Evaluation of microfluidic channels with optical coherence tomography

KAUST Repository

Czajkowski, J.; Prykä ri, T.; Alarousu, E.; Lauri, J.; Myllylä , R.

2010-01-01

Application of time domain, ultra high resolution optical coherence tomography (UHR-OCT) in evaluation of microfluidic channels is demonstrated. Presented study was done using experimental UHR-OCT device based on a Kerr-lens mode locked Ti:sapphire femtosecond laser, a photonic crystal fibre and modified, free-space Michelson interferometer. To show potential of the technique, microfluidic chip fabricated by VTT Center for Printed Intelligence (Oulu, Finland) was measured. Ability for full volumetric reconstruction in non-contact manner enabled complete characterization of closed entity of a microfluidic channel without contamination and harm for the sample. Measurement, occurring problems, and methods of postprocessing for raw data are described. Results present completely resolved physical structure of the channel, its spatial dimensions, draft angles and evaluation of lamination quality.

Optical Coherence Tomographic Findings in Berlin′s Edema

Directory of Open Access Journals (Sweden)

Leila El Matri

2010-01-01

Full Text Available Purpose: To describe optical coherence tomography (OCT findings in a patient with Berlin′s edema following blunt ocular trauma. Case Report: A 26-year-old man presented with acute loss of vision in his left eye following blunt trauma. He underwent a complete ophthalmologic examination and OCT. Fundus examination revealed abnormal yellow discoloration in the macula. OCT disclosed thickening of outer retinal structures and increased reflectivity in the area of photoreceptor outer segments with preservation of inner retinal architecture. Re-examination was conducted one month later at the time which OCT changes resolved leading to a surprisingly normal appearance. Conclusion: OCT can be a useful tool in the diagnosis and follow-up of eyes with Berlin′s edema and may reveal ultrastructural macular changes.

Evaluation of microfluidic channels with optical coherence tomography

KAUST Repository

Czajkowski, J.

2010-06-25

Application of time domain, ultra high resolution optical coherence tomography (UHR-OCT) in evaluation of microfluidic channels is demonstrated. Presented study was done using experimental UHR-OCT device based on a Kerr-lens mode locked Ti:sapphire femtosecond laser, a photonic crystal fibre and modified, free-space Michelson interferometer. To show potential of the technique, microfluidic chip fabricated by VTT Center for Printed Intelligence (Oulu, Finland) was measured. Ability for full volumetric reconstruction in non-contact manner enabled complete characterization of closed entity of a microfluidic channel without contamination and harm for the sample. Measurement, occurring problems, and methods of postprocessing for raw data are described. Results present completely resolved physical structure of the channel, its spatial dimensions, draft angles and evaluation of lamination quality.

Evaluation of microfluidic channels with optical coherence tomography

Science.gov (United States)

Czajkowski, J.; Prykäri, T.; Alarousu, E.; Lauri, J.; Myllylä, R.

2010-11-01

Application of time domain, ultra high resolution optical coherence tomography (UHR-OCT) in evaluation of microfluidic channels is demonstrated. Presented study was done using experimental UHR-OCT device based on a Kerr-lens mode locked Ti:sapphire femtosecond laser, a photonic crystal fibre and modified, free-space Michelson interferometer. To show potential of the technique, microfluidic chip fabricated by VTT Center for Printed Intelligence (Oulu, Finland) was measured. Ability for full volumetric reconstruction in non-contact manner enabled complete characterization of closed entity of a microfluidic channel without contamination and harm for the sample. Measurement, occurring problems, and methods of postprocessing for raw data are described. Results present completely resolved physical structure of the channel, its spatial dimensions, draft angles and evaluation of lamination quality.

Intracoronary optical coherence tomography

DEFF Research Database (Denmark)

Tenekecioglu, Erhan; Albuquerque, Felipe N; Sotomi, Yohei

2017-01-01

By providing valuable information about the coronary artery wall and lumen, intravascular imaging may aid in optimizing interventional procedure results and thereby could improve clinical outcomes following percutaneous coronary intervention (PCI). Intravascular optical coherence tomography (OCT...

Intra-operative application of optical coherence tomography with an operating microscope.

Science.gov (United States)

Just, T; Lankenau, E; Hüttmann, G; Pau, H W

2009-09-01

To introduce the use of optical coherence tomography with an operating microscope for intra-operative evaluation of the human larynx. A specially equipped operating microscope with integrated spectral domain optical coherence tomography apparatus was used during microlaryngoscopy. Technical improvements in optical coherence tomography equipment (e.g. pilot beam, variable focal distance, improved image quality and integration into an operating microscope) have enabled greater sensitivity and imaging speed and a non-contact approach. Spectral domain optical coherence tomography now enables a better correlation between optical coherence tomography images and histological findings. With this new technology, the precision of biopsy can be improved during microlaryngoscopy. Use of this new optical coherence tomography technology, integrated into an operating microscope, enables the surgeon to define the biopsy site location and resection plane precisely, while the optical zoom of the operating microscope can be used over the complete range.

Full-field parallel interferometry coherence probe microscope for high-speed optical metrology.

Science.gov (United States)

Safrani, A; Abdulhalim, I

2015-06-01

Parallel detection of several achromatic phase-shifted images is used to obtain a high-speed, high-resolution, full-field, optical coherence probe tomography system based on polarization interferometry. The high enface imaging speed, short coherence gate, and high lateral resolution provided by the system are exploited to determine microbump height uniformity in an integrated semiconductor chip at 50 frames per second. The technique is demonstrated using the Linnik microscope, although it can be implemented on any polarization-based interference microscopy system.

Fourier-domain angle-resolved low coherence interferometry for clinical detection of dysplasia

Science.gov (United States)

Terry, Neil G.; Zhu, Yizheng; Wax, Adam

2010-02-01

Improved methods for detecting dysplasia, or pre-cancerous growth are a current clinical need, particularly in the esophagus. The currently accepted method of random biopsy and histological analysis provides only a limited examination of tissue in question while being coupled with a long time delay for diagnosis. Light scattering spectroscopy, in contrast, allows for inspection of the cellular structure and organization of tissue in vivo. Fourier-domain angle-resolved low-coherence interferometry (a/LCI) is a novel light scattering spectroscopy technique that provides quantitative depth-resolved morphological measurements of the size and optical density of the examined cell nuclei, which are characteristic biomarkers of dysplasia. Previously, clinical viability of the a/LCI system was demonstrated through analysis of ex vivo human esophageal tissue in Barrett's esophagus patients using a portable a/LCI, as was the development of a clinical a/LCI system. Data indicating the feasibility of the technique in other organ sites (colon, oral cavity) will be presented. We present an adaptation of the a/LCI system that will be used to investigate the presence of dysplasia in vivo in Barrett's esophagus patients.

Broadband demonstrations of true-time delay using linear sideband chirped programming and optical coherent transients

International Nuclear Information System (INIS)

Reibel, R.R.; Barber, Z.W.; Fischer, J.A.; Tian, M.; Babbitt, W.R.

2004-01-01

Linear sideband chirped (LSC) programming is introduced as a means of configuring spatial-spectral holographic gratings for optical coherent transient processors. Similar to linear frequency chirped programming, LSC programming allows the use of broadband integrated electro-optic phase modulators to produce chirps instead of using elaborate broadband chirped lasers. This approach has several advantages including the ability to use a stabilized laser for the optical carrier as well as stable, reproducible chirped optical signals when the modulator is driven digitally. Using LSC programming, we experimentally demonstrate broadband true-time delay as a proof of principle for the optical control of phased array radars. Here both cw phase modulated and binary phase shift keyed probe signals are true-time delayed with bandwidths of 1 GHz and delay resolutions better than 60 ps

Non-Markovian response of ultrafast coherent electronic ring currents in chiral aromatic molecules in a condensed phase

International Nuclear Information System (INIS)

Mineo, H.; Lin, S. H.; Fujimura, Y.; Xu, J.; Xu, R. X.; Yan, Y. J.

2013-01-01

Results of a theoretical study on non-Markov response for femtosecond laser-driven coherent ring currents in chiral aromatic molecules embedded in a condensed phase are presented. Coherent ring currents are generated by coherent excitation of a pair of quasi-degenerated π-electronic excited states. The coherent electronic dynamical behaviors are strongly influenced by interactions between the electronic system and phonon bath in a condensed phase. Here, the bath correlation time is not instantaneous but should be taken to be a finite time in ultrashort time-resolved experiments. In such a case, Markov approximation breaks down. A hierarchical master equation approach for an improved semiclassical Drude dissipation model was adopted to examine the non-Markov effects on ultrafast coherent electronic ring currents of (P)-2,2 ′ -biphenol in a condensed phase. Time evolution of the coherent ring current derived in the hierarchical master equation approach was calculated and compared with those in the Drude model in the Markov approximation and in the static limit. The results show how non-Markovian behaviors in quantum beat signals of ring currents depend on the Drude bath damping constant. Effects of temperatures on ultrafast coherent electronic ring currents are also clarified

Optics for coherent X-ray applications

Energy Technology Data Exchange (ETDEWEB)

Yabashi, Makina, E-mail: yabashi@spring8.or.jp [RIKEN SPring-8 Center, Kouto 1-1-1, Sayo, Hyogo 679-5148 (Japan); Tono, Kensuke [Japan Synchrotron Radiation Research Institute (JASRI), Kouto 1-1-1, Sayo, Hyogo 679-5198 (Japan); Mimura, Hidekazu [The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656 (Japan); Matsuyama, Satoshi; Yamauchi, Kazuto [Osaka University, 2-1 Yamada-oka, Suita, Osaka 565-0871 (Japan); Tanaka, Takashi; Tanaka, Hitoshi; Tamasaku, Kenji [RIKEN SPring-8 Center, Kouto 1-1-1, Sayo, Hyogo 679-5148 (Japan); Ohashi, Haruhiko; Goto, Shunji [Japan Synchrotron Radiation Research Institute (JASRI), Kouto 1-1-1, Sayo, Hyogo 679-5198 (Japan); Ishikawa, Tetsuya [RIKEN SPring-8 Center, Kouto 1-1-1, Sayo, Hyogo 679-5148 (Japan)

2014-08-27

Developments of optics for coherent X-ray applications and their role in diffraction-limited storage rings are described. Developments of X-ray optics for full utilization of diffraction-limited storage rings (DLSRs) are presented. The expected performance of DLSRs is introduced using the design parameters of SPring-8 II. To develop optical elements applicable to manipulation of coherent X-rays, advanced technologies on precise processing and metrology were invented. With propagation-based coherent X-rays at the 1 km beamline of SPring-8, a beryllium window fabricated with the physical-vapour-deposition method was found to have ideal speckle-free properties. The elastic emission machining method was utilized for developing reflective mirrors without distortion of the wavefronts. The method was further applied to production of diffraction-limited focusing mirrors generating the smallest spot size in the sub-10 nm regime. To enable production of ultra-intense nanobeams at DLSRs, a low-vibration cooling system for a high-heat-load monochromator and advanced diagnostic systems to characterize X-ray beam properties precisely were developed. Finally, new experimental schemes for combinative nano-analysis and spectroscopy realised with novel X-ray optics are discussed.

Phase-space evolution of x-ray coherence in phase-sensitive imaging.

Science.gov (United States)

Wu, Xizeng; Liu, Hong

2008-08-01

X-ray coherence evolution in the imaging process plays a key role for x-ray phase-sensitive imaging. In this work we present a phase-space formulation for the phase-sensitive imaging. The theory is reformulated in terms of the cross-spectral density and associated Wigner distribution. The phase-space formulation enables an explicit and quantitative account of partial coherence effects on phase-sensitive imaging. The presented formulas for x-ray spectral density at the detector can be used for performing accurate phase retrieval and optimizing the phase-contrast visibility. The concept of phase-space shearing length derived from this phase-space formulation clarifies the spatial coherence requirement for phase-sensitive imaging with incoherent sources. The theory has been applied to x-ray Talbot interferometric imaging as well. The peak coherence condition derived reveals new insights into three-grating-based Talbot-interferometric imaging and gratings-based x-ray dark-field imaging.

Radio over fiber link with adaptive order n‐QAM optical phase modulated OFDM and digital coherent detection

DEFF Research Database (Denmark)

Arlunno, Valeria; Borkowski, Robert; Guerrero Gonzalez, Neil

2011-01-01

Successful digital coherent demodulation of asynchronous optical phase‐modulated adaptive order QAM (4, 16, and 64) orthogonal frequency division multiplexing signals is achieved by a single reconfigurable digital receiver after 78 km of optical deployed fiber transmission....

Coherent Control of Multiphoton Transitions in the Gas and Condensed Phases with Shaped Ultrashort Pulses

International Nuclear Information System (INIS)

Dantus, Marcos

2008-01-01

Controlling laser-molecule interactions has become an integral part of developing devices and applications in spectroscopy, microscopy, optical switching, micromachining and photochemistry. Coherent control of multiphoton transitions could bring a significant improvement of these methods. In microscopy, multi-photon transitions are used to activate different contrast agents and suppress background fluorescence; coherent control could generate selective probe excitation. In photochemistry, different dissociative states are accessed through two, three, or more photon transitions; coherent control could be used to select the reaction pathway and therefore the yield-specific products. For micromachining and processing a wide variety of materials, femtosecond lasers are now used routinely. Understanding the interactions between the intense femtosecond pulse and the material could lead to technologically important advances. Pulse shaping could then be used to optimize the desired outcome. The scope of our research program is to develop robust and efficient strategies to control nonlinear laser-matter interactions using ultrashort shaped pulses in gas and condensed phases. Our systematic research has led to significant developments in a number of areas relevant to the AMO Physics group at DOE, among them: generation of ultrashort phase shaped pulses, coherent control and manipulation of quantum mechanical states in gas and condensed phases, behavior of isolated molecules under intense laser fields, behavior of condensed phase matter under intense laser field and implications on micromachining with ultrashort pulses, coherent control of nanoparticles their surface plasmon waves and their nonlinear optical behavior, and observation of coherent Coulomb explosion processes at 10 16 W/cm 2 . In all, the research has resulted in 36 publications (five journal covers) and nine invention disclosures, five of which have continued on to patenting

Simultaneous topography and tomography of latent fingerprints using full-field swept-source optical coherence tomography

Science.gov (United States)

Dubey, Satish Kumar; Singh Mehta, Dalip; Anand, Arun; Shakher, Chandra

2008-01-01

We demonstrate simultaneous topography and tomography of latent fingerprints using full-field swept-source optical coherence tomography (OCT). The swept-source OCT system comprises a superluminescent diode (SLD) as broad-band light source, an acousto-optic tunable filter (AOTF) as frequency tuning device, and a compact, nearly common-path interferometer. Both the amplitude and the phase map of the interference fringe signal are reconstructed. Optical sectioning of the latent fingerprint sample is obtained by selective Fourier filtering and the topography is retrieved from the phase map. Interferometry, selective filtering, low coherence and hence better resolution are some of the advantages of the proposed system over the conventional fingerprint detection techniques. The present technique is non-invasive in nature and does not require any physical or chemical processing. Therefore, the quality of the sample does not alter and hence the same fingerprint can be used for other types of forensic test. Exploitation of low-coherence interferometry for fingerprint detection itself provides an edge over other existing techniques as fingerprints can even be lifted from low-reflecting surfaces. The proposed system is very economical and compact.

Revisiting Bragg's X-ray microscope: scatter based optical transient grating detection of pulsed ionising radiation.

Science.gov (United States)

Fullagar, Wilfred K; Paganin, David M; Hall, Chris J

2011-06-01

Transient optical gratings for detecting ultrafast signals are routine for temporally resolved photochemical investigations. Many processes can contribute to the formation of such gratings; we indicate use of optically scattering centres that can be formed with highly variable latencies in different materials and devices using ionising radiation. Coherent light scattered by these centres can form the short-wavelength-to-optical-wavelength, incoherent-to-coherent basis of a Bragg X-ray microscope, with inherent scope for optical phasing. Depending on the dynamics of the medium chosen, the way is open to both ultrafast pulsed and integrating measurements. For experiments employing brief pulses, we discuss high-dynamic-range short-wavelength diffraction measurements with real-time optical reconstructions. Applications to optical real-time X-ray phase-retrieval are considered. Copyright © 2010 Elsevier B.V. All rights reserved.

Measurement of Sub-Picosecond Electron Bunches via Electro-Optic Sampling of Coherent Transition Radiation

Energy Technology Data Exchange (ETDEWEB)

Maxwell, Timothy John [Northern Illinois U.

2012-01-01

Future collider applications as well as present high-gradient laser plasma wakefield accelerators and free-electron lasers operating with picosecond bunch durations place a higher demand on the time resolution of bunch distribution diagnostics. This demand has led to significant advancements in the field of electro-optic sampling over the past ten years. These methods allow the probing of diagnostic light such as coherent transition radiation or the bunch wakefields with sub-picosecond time resolution. We present results on the single-shot electro-optic spectral decoding of coherent transition radiation from bunches generated at the Fermilab A0 photoinjector laboratory. A longitudinal double-pulse modulation of the electron beam is also realized by transverse beam masking followed by a transverse-to-longitudinal phase-space exchange beamline. Live profile tuning is demonstrated by upstream beam focusing in conjunction with downstream monitoring of single-shot electro-optic spectral decoding of the coherent transition radiation.

Revisiting Bragg's X-ray microscope: Scatter based optical transient grating detection of pulsed ionising radiation

International Nuclear Information System (INIS)

Fullagar, Wilfred K.; Paganin, David M.; Hall, Chris J.

2011-01-01

Transient optical gratings for detecting ultrafast signals are routine for temporally resolved photochemical investigations. Many processes can contribute to the formation of such gratings; we indicate use of optically scattering centres that can be formed with highly variable latencies in different materials and devices using ionising radiation. Coherent light scattered by these centres can form the short-wavelength-to-optical-wavelength, incoherent-to-coherent basis of a Bragg X-ray microscope, with inherent scope for optical phasing. Depending on the dynamics of the medium chosen, the way is open to both ultrafast pulsed and integrating measurements. For experiments employing brief pulses, we discuss high-dynamic-range short-wavelength diffraction measurements with real-time optical reconstructions. Applications to optical real-time X-ray phase-retrieval are considered. -- Research highlights: → It is timely that the concept of Bragg's X-ray microscope be revisited. → Transient gratings can be used for X-ray all-optical information processing. → Applications to optical real-time X-ray phase-retrieval are considered.

Depth-resolved phase retardation measurements for laser-assisted non-ablative cartilage reshaping

Energy Technology Data Exchange (ETDEWEB)

Youn, Jong-In [Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92612 (United States); Vargas, Gracie [Center for Bioengineering, University of Texas Medical Branch, Galveston, TX 77555 (United States); Wong, Brian J F [Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92612 (United States); Milner, Thomas E [Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712 (United States)

2005-05-07

Since polarization-sensitive optical coherence tomography (PS-OCT) is emerging as a new technique for determining phase retardation in biological materials, we measured phase retardation changes in cartilage during local laser heating for application to laser-assisted cartilage reshaping. Thermally-induced changes in phase retardation of nasal septal cartilage following Nd:YAG laser irradiation were investigated using a PS-OCT system. A PS-OCT system and infrared imaging radiometer were used to record, respectively, depth-resolved images of the Stokes parameters of light backscattered from ex vivo porcine nasal septal cartilage and radiometric temperature changes following laser irradiation. PS-OCT images of cartilage were recorded before (control), during and after laser irradiation. From the measured Stokes parameters (I, Q, U and V), an estimate of the relative phase retardation between two orthogonal polarizations was computed to determine birefringence in cartilage. Phase retardation images of light backscattered from cartilage show significant changes in retardation following laser irradiation. To investigate the origin of retardation changes in response to local heat generation, we differentiated two possible mechanisms: dehydration and thermal denaturation. PS-OCT images of cartilage were recorded after dehydration in glycerol and thermal denaturation in heated physiological saline. In our experiments, observed retardation changes in cartilage are primarily due to dehydration. Since dehydration is a principal source for retardation changes in cartilage over the range of heating profiles investigated, our studies suggest that the use of PS-OCT as a feedback control methodology for non-ablative cartilage reshaping requires further investigation.

Depth-resolved phase retardation measurements for laser-assisted non-ablative cartilage reshaping

International Nuclear Information System (INIS)

Youn, Jong-In; Vargas, Gracie; Wong, Brian J F; Milner, Thomas E

2005-01-01

Since polarization-sensitive optical coherence tomography (PS-OCT) is emerging as a new technique for determining phase retardation in biological materials, we measured phase retardation changes in cartilage during local laser heating for application to laser-assisted cartilage reshaping. Thermally-induced changes in phase retardation of nasal septal cartilage following Nd:YAG laser irradiation were investigated using a PS-OCT system. A PS-OCT system and infrared imaging radiometer were used to record, respectively, depth-resolved images of the Stokes parameters of light backscattered from ex vivo porcine nasal septal cartilage and radiometric temperature changes following laser irradiation. PS-OCT images of cartilage were recorded before (control), during and after laser irradiation. From the measured Stokes parameters (I, Q, U and V), an estimate of the relative phase retardation between two orthogonal polarizations was computed to determine birefringence in cartilage. Phase retardation images of light backscattered from cartilage show significant changes in retardation following laser irradiation. To investigate the origin of retardation changes in response to local heat generation, we differentiated two possible mechanisms: dehydration and thermal denaturation. PS-OCT images of cartilage were recorded after dehydration in glycerol and thermal denaturation in heated physiological saline. In our experiments, observed retardation changes in cartilage are primarily due to dehydration. Since dehydration is a principal source for retardation changes in cartilage over the range of heating profiles investigated, our studies suggest that the use of PS-OCT as a feedback control methodology for non-ablative cartilage reshaping requires further investigation

Fundamental characteristics of a synthesized light source for optical coherence tomography.

Science.gov (United States)

Sato, Manabu; Wakaki, Ichiro; Watanabe, Yuuki; Tanno, Naohiro

2005-05-01

We describe the fundamental characteristics of a synthesized light source (SLS) consisting of two low-coherence light sources to enhance the spatial resolution for optical coherence tomography (OCT). The axial resolution of OCT is given by half the coherence length of the light source. We fabricated a SLS with a coherence length of 2.3 microm and a side-lobe intensity of 45% with an intensity ratio of LED1:LED2 = 1:0.5 by combining two light sources, LED1, with a central wavelength of 691 nm and a spectral bandwidth of 99 nm, and LED2, with a central wavelength of 882 nm and a spectral bandwidth of 76 nm. The coherence length of 2.3 microm was 56% of the shorter coherence length in the two LEDs, which indicates that the axial resolution is 1.2 microm. The lateral resolution was measured at less than 4.4 microm by use of the phase-shift method and with a test pattern as a sample. The measured rough surfaces of a coin are illustrated and discussed.

Performance Evaluation of Digital Coherent Receivers for Phase-Modulated Radio-Over-Fiber Links

DEFF Research Database (Denmark)

Caballero Jambrina, Antonio; Zibar, Darko; Tafur Monroy, Idelfonso

2011-01-01

The performance of optical phase-modulated (PM) radio-over-fiber (RoF) links assisted with coherent detection and digital signal processing (PM-Coh) is analyzed and experimentally demonstrated for next-generation wireless-over-fiber systems. PM-Coh offers high linearity for transparent transport ...

Experimental characterization of X-ray transverse coherence in the presence of beam transport optics

DEFF Research Database (Denmark)

Chubar, O.; Fluerasu, A.; Chu, Y.S.

2013-01-01

A simple Boron fiber based interference scheme [1] and other similar schemes are currently routinely used for X-ray coherence estimation at 3rd generation synchrotron radiation sources. If such a scheme is applied after a perfect monochromator and without any focusing / transport optics...... in the optical path, the interpretation of the measured interference pattern is relatively straightforward and can be done in terms of the basic parameters of the source [2]. However, if the interference scheme is used after some focusing optics, e.g. close to the X-ray beam waist, the visibility of fringes can...... be significantly affected by the new shape of the focused beam phase-space. At the same time, optical element imperfections still have a negative impact on the transverse coherence. In such situations, which are frequently encountered in experiments at beamlines, the quantitative interpretation of a measured...

Self-Mixing Demodulation for Coherent Phase-Sensitive OTDR System

Directory of Open Access Journals (Sweden)

Haijun He

2016-05-01

Full Text Available Phase-sensitive optical time domain reflectometry (Ф-OTDR attracts much attention due to its capability of telling the type and position of an intrusion simultaneously. In recent decades, coherent Ф-OTDR has been demonstrated to realize long-distance detection. For coherent Ф-OTDR, there are three typical demodulation schemes in the reported studies. However, they still cannot realize real-time monitoring to satisfy practical demands. A simple and effective demodulation method based on self-mixing has been put forward to demodulate the beat signal in coherent Ф-OTDR. It not only saves a local electrical oscillator and frequency locked loop, but also demodulates the beat signal without residual frequency. Several vibrations with different frequency were separately applied at the same location of a 42.5 km fiber. The spatial resolution of 10 m and frequency response range from 8 Hz to 980 Hz have been achieved. The precise location with signal-to-noise ratio of 21.4 dB and broadband measurement demonstrate the self-mixing scheme can demodulate the coherent Ф-OTDR signal effectively.

Temporal characterization of FEL micropulses as function of cavity length detuning using frequency-resolved optical gating

Energy Technology Data Exchange (ETDEWEB)

Richman, B.A. [Stanford Univ., CA (United States); DeLong, K.W.; Trebino, R. [Sandia National Lab., Livermore, CA (United States)

1995-12-31

Results of frequency resolved optical gating (FROG) measurements on the Stanford mid-IR FEL system show the effect of FEL cavity length detuning on the micropulse temporal structure. The FROG technique enables the acquisition of complete and uniquely invertible amplitude and phase temporal dependence of optical pulses. Unambiguous phase and amplitude profiles are recovered from the data. The optical pulses are nearly transform limited, and the pulse length increases with cavity length detuning.

Depth-resolved incoherent and coherent wide-field high-content imaging (Conference Presentation)

Science.gov (United States)

So, Peter T.

2016-03-01

Recent advances in depth-resolved wide-field imaging technique has enabled many high throughput applications in biology and medicine. Depth resolved imaging of incoherent signals can be readily accomplished with structured light illumination or nonlinear temporal focusing. The integration of these high throughput systems with novel spectroscopic resolving elements further enable high-content information extraction. We will introduce a novel near common-path interferometer and demonstrate its uses in toxicology and cancer biology applications. The extension of incoherent depth-resolved wide-field imaging to coherent modality is non-trivial. Here, we will cover recent advances in wide-field 3D resolved mapping of refractive index, absorbance, and vibronic components in biological specimens.

Doppler optical coherence microscopy and tomography applied to inner ear mechanics

Energy Technology Data Exchange (ETDEWEB)

Page, Scott; Freeman, Dennis M. [Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts (United States); Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts (United States); Ghaffari, Roozbeh [Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts (United States)

2015-12-31

While it is clear that cochlear traveling waves underlie the extraordinary sensitivity, frequency selectivity, and dynamic range of mammalian hearing, the underlying micromechanical mechanisms remain unresolved. Recent advances in low coherence measurement techniques show promise over traditional laser Doppler vibrometry and video microscopy, which are limited by low reflectivities of cochlear structures and restricted optical access. Doppler optical coherence tomography (DOCT) and Doppler optical coherence microscopy (DOCM) both utilize a broadband source to limit constructive interference of scattered light to a small axial depth called a coherence gate. The coherence gate can be swept axially to image and measure sub-nanometer motions of cochlear structures throughout the cochlear partition. The coherence gate of DOCT is generally narrower than the confocal gate of the focusing optics, enabling increased axial resolution (typically 15 μm) within optical sections of the cochlear partition. DOCM, frequently implemented in the time domain, centers the coherence gate on the focal plane, achieving enhanced lateral and axial resolution when the confocal gate is narrower than the coherence gate. We compare these two complementary systems and demonstrate their utility in studying cellular and micromechanical mechanisms involved in mammalian hearing.

Coherence-Multiplexed Optical RF Feeder Networks

NARCIS (Netherlands)

Meijerink, Arjan; Taniman, R.O.; van Etten, Wim

2007-01-01

An optical RF feeding system for wireless access is proposed, in which the radio access points are distinguished by means of coherence multiplexing (CM). CM is a rather unknown and potentially inexpensive optical code division multiple access technique, which is particularly suitable for relatively

Optical coherence tomography in conjunction with bronchoscopy

International Nuclear Information System (INIS)

Rodrigues, Ascedio Jose; Takimura, Celso Kiyochi; Lemos Neto, Pedro Alves; Figueiredo, Viviane Rossi

2012-01-01

To evaluate the feasibility of and the potential for using optical coherence tomography in conjunction with conventional bronchoscopy in the evaluation of the airways. Methods: This was a pilot study based on an ex vivo experimental model involving three animals: one adult New Zealand rabbit and two Landrace pigs. An optical coherence tomography imaging catheter was inserted through the working channel of a flexible bronchoscope in order to reach the distal trachea of the animals. Images of the walls of the trachea were systematically taken along its entire length, from the distal to the proximal portion. Results: The imaging catheter was easily adapted to the working channel of the bronchoscope. High-resolution images of cross sections of the trachea were taken in real time, precisely delineating microstructures, such as the epithelium, submucosa, and cartilage, as well as the adventitia of the anterior and lateral tracheal walls. The corresponding layers of the epithelium, mucosa, and cartilage were clearly differentiated. The mucosa, submucosa, and trachealis muscle were clearly identified in the posterior wall. Conclusions: It is feasible to use an optical coherence tomography imaging catheter in combination with a flexible bronchoscope. Optical coherence tomography produces high resolution images that reveal the microanatomy of the trachea, including structures that are typically seen only on images produced by conventional histology. (author)

Optical coherence tomography in conjunction with bronchoscopy

Energy Technology Data Exchange (ETDEWEB)

Rodrigues, Ascedio Jose; Takimura, Celso Kiyochi; Lemos Neto, Pedro Alves; Figueiredo, Viviane Rossi, E-mail: ascedio@gmail.com [Servico de Endoscopia Respiratoria, Hospital das Clinicas, Universidade de Sao Paulo (FM/USP), SP (Brazil)

2012-07-01

To evaluate the feasibility of and the potential for using optical coherence tomography in conjunction with conventional bronchoscopy in the evaluation of the airways. Methods: This was a pilot study based on an ex vivo experimental model involving three animals: one adult New Zealand rabbit and two Landrace pigs. An optical coherence tomography imaging catheter was inserted through the working channel of a flexible bronchoscope in order to reach the distal trachea of the animals. Images of the walls of the trachea were systematically taken along its entire length, from the distal to the proximal portion. Results: The imaging catheter was easily adapted to the working channel of the bronchoscope. High-resolution images of cross sections of the trachea were taken in real time, precisely delineating microstructures, such as the epithelium, submucosa, and cartilage, as well as the adventitia of the anterior and lateral tracheal walls. The corresponding layers of the epithelium, mucosa, and cartilage were clearly differentiated. The mucosa, submucosa, and trachealis muscle were clearly identified in the posterior wall. Conclusions: It is feasible to use an optical coherence tomography imaging catheter in combination with a flexible bronchoscope. Optical coherence tomography produces high resolution images that reveal the microanatomy of the trachea, including structures that are typically seen only on images produced by conventional histology. (author)

On the estimation of wall pressure coherence using time-resolved tomographic PIV

Science.gov (United States)

Pröbsting, Stefan; Scarano, Fulvio; Bernardini, Matteo; Pirozzoli, Sergio

2013-07-01

Three-dimensional time-resolved velocity field measurements are obtained using a high-speed tomographic Particle Image Velocimetry (PIV) system on a fully developed flat plate turbulent boundary layer for the estimation of wall pressure fluctuations. The work focuses on the applicability of tomographic PIV to compute the coherence of pressure fluctuations, with attention to the estimation of the stream and spanwise coherence length. The latter is required for estimations of aeroacoustic noise radiation by boundary layers and trailing edge flows, but is also of interest for vibro-structural problems. The pressure field is obtained by solving the Poisson equation for incompressible flows, where the source terms are provided by time-resolved velocity field measurements. Measured 3D velocity data is compared to results obtained from planar PIV, and a Direct Numerical Simulation (DNS) at similar Reynolds number. An improved method for the estimation of the material based on a least squares estimator of the velocity derivative along a particle trajectory is proposed and applied. Computed surface pressure fluctuations are further verified by means of simultaneous measurements by a pinhole microphone and compared to the DNS results and a semi-empirical model available from literature. The correlation coefficient for the reconstructed pressure time series with respect to pinhole microphone measurements attains approximately 0.5 for the band-pass filtered signal over the range of frequencies resolved by the velocity field measurements. Scaled power spectra of the pressure at a single point compare favorably to the DNS results and those available from literature. Finally, the coherence of surface pressure fluctuations and the resulting span- and streamwise coherence lengths are estimated and compared to semi-empirical models and DNS results.

High-definition optical coherence tomography

DEFF Research Database (Denmark)

Boone, Marc; Norrenberg, Sarah; Jemec, Gregor

2013-01-01

to those described for reflectance confocal microscopy but with the advantages not only to visualize individual cells up to a depth of 570 μm but also in both slice and en face mode. An adapted algorithmic method for pattern analysis of common inflammatory skin diseases could be proposed. This new......High-definition optical coherence tomography (HD-OCT) is a non-invasive technique for morphological investigation of tissue with cellular resolution filling the imaging gap between reflectance confocal microscopy and conventional optical coherence tomography. The aim of this study is first...... dermatitis. Additional studies to test the sensitivity and specificity of the proposed algorithm for pattern analysis are essential. The other categories of Ackerman's pattern recognition need to be evaluated. This study provides a set of morphological features generated by HD-OCT imaging very similar...

Characterisation of optically cleared paper by optical coherence tomography

International Nuclear Information System (INIS)

Fabritius, T; Alarousu, E; Prykaeri, T; Hast, J; Myllylae, Risto

2006-01-01

Due to the highly light scattering nature of paper, the imaging depth of optical methods such as optical coherence tomography (OCT) is limited. In this work, we study the effect of refractive index matching on improving the imaging depth of OCT in paper. To this end, four different refractive index matching liquids (ethanol, 1-pentanol, glycerol and benzyl alcohol) with a refraction index between 1.359 and 1.538 were used in experiments. Low coherent light transmission was studied in commercial copy paper sheets, and the results indicate that benzyl alcohol offers the best improvement in imaging depth, while also being sufficiently stable for the intended purpose. Constructed cross-sectional images demonstrate visually that the imaging depth of OCT is considerably improved by optical clearing. Both surfaces of paper sheets can be detected along with information about the sheet's inner structure. (laser applications and other topics in quantum electronics)

In-vivo imaging of blood flow dynamics using color Doppler optical coherence tomography

Science.gov (United States)

Yazdanfar, Siavash; Rollins, Andrew M.; Izatt, Joseph A.

2000-04-01

Noninvasive quantitation of blood flow in the retinal micro circulation may elucidate the progression and treatment of ocular disorders including diabetic retinopathy, age-related degeneration, and glaucoma. Color Doppler optical coherence tomography was recently introduced as a technique allowing simultaneous micron-scale resolution cross-sectional imaging of tissue micro structure and blood flow in the human retina. Here, time-resolved imaging of dynamics of blood flow profiles was performed to measure cardiac pulsatility within retinal vessels. Retinal pulsatility has been shown to decrease throughout the progression of diabetic retinopathy.

Endoscopic optical coherence tomography for imaging the tympanic membrane

Science.gov (United States)

Burkhardt, Anke; Walther, Julia; Cimalla, Peter; Bornitz, Matthias; Koch, Edmund

2011-06-01

Optical coherence tomography (OCT) is an imaging modality that enables micrometer-scale contactless subsurface imaging of biological tissue. Endoscopy, as another imaging method, has the potential of imaging tubular organs and cavities and therefore has opened up several application areas not accessible before. The combination of OCT and endoscopy uses the advantages of both methods and consequently allows additional imaging of structures beneath surfaces inside cavities. Currently, visual investigations on the surface of the human tympanic membrane are possible but only with expert eyes. up to now, visual imaging of the outer ear up to the tympanic membrane can be carried out by an otoscope, an operating microscope or an endoscope. In contrast to these devices, endoscopy has the advantage of imaging the whole tympanic membrane with one view. The intention of this research is the development of an endoscopic optical coherence tomography (EOCT) device for imaging the tympanic membrane depth-resolved and structures behind it. Detection of fluids in the middle ear, which function as an indicator for otitis media, could help to avoid the application of antibiotics. It is possible to detect a congeries of fluids with the otoscope but the ambition is to the early detection by OCT. The developed scanner head allows imaging in working distances in the range from zero up to 5 mm with a field of view of 2 mm. In the next step, the scanner head should be improved to increase the working distance and the field of view.

Optical Phase Recovery and Locking in a PPM Laser Communication Link

Science.gov (United States)

Aveline, David C.; Yu, Nan; Farr, William H.

2012-01-01

Free-space optical communication holds great promise for future space missions requiring high data rates. For data communication in deep space, the current architecture employs pulse position modulation (PPM). In this scheme, the light is transmitted and detected as pulses within an array of time slots. While the PPM method is efficient for data transmission, the phase of the laser light is not utilized. The phase coherence of a PPM optical signal has been investigated with the goal of developing a new laser communication and ranging scheme that utilizes optical coherence within the established PPM architecture and photon-counting detection (PCD). Experimental measurements of a PPM modulated optical signal were conducted, and modeling code was developed to generate random PPM signals and simulate spectra via FFT (Fast Fourier Transform) analysis. The experimental results show very good agreement with the simulations and confirm that coherence is preserved despite modulation with high extinction ratios and very low duty cycles. A real-time technique has been developed to recover the phase information through the mixing of a PPM signal with a frequency-shifted local oscillator (LO). This mixed signal is amplified, filtered, and integrated to generate a voltage proportional to the phase of the modulated signal. By choosing an appropriate time constant for integration, one can maintain a phase lock despite long dark times between consecutive pulses with low duty cycle. A proof-of-principle demonstration was first achieved with an RF-based PPM signal and test setup. With the same principle method, an optical carrier within a PPM modulated laser beam could also be tracked and recovered. A reference laser was phase-locked to an independent pulsed laser signal with low-duty-cycle pseudo-random PPM codes. In this way, the drifting carrier frequency in the primary laser source is tracked via its phase change in the mixed beat note, while the corresponding voltage feedback

Task-and phase-related changes in cortico-muscular coherence

DEFF Research Database (Denmark)

Masakado, Yoshihisa; Nielsen, Jens Bo

2008-01-01

-level tonic dorsiflexion. In all subjects coherence disappeared during the ramp phase for both isometric and quasi-isotonic contraction. Coherence at other frequencies was also not observed in any of the subjects during the ramp phase. During the hold phase at the stronger level of contraction coherence...... reappeared quickly and had the same size as at the low level of contraction. However, a significantly larger level of coherence was found during quasi-isotonic than during the isometric contraction. This demonstrates that cortico-muscular coherence in the 15-35 Hz frequency band is phase- and task......-related. The decrease in 15-35 Hz coherence during the ramp phase may be related to event-related desynchronization of EEG activity. The larger level of coherence during quasi-isotonic contraction may reflect a higher demand of precise control of the joint position. It may also reflect a greater need for binding...

Audio frequency in vivo optical coherence elastography

Science.gov (United States)

Adie, Steven G.; Kennedy, Brendan F.; Armstrong, Julian J.; Alexandrov, Sergey A.; Sampson, David D.

2009-05-01

We present a new approach to optical coherence elastography (OCE), which probes the local elastic properties of tissue by using optical coherence tomography to measure the effect of an applied stimulus in the audio frequency range. We describe the approach, based on analysis of the Bessel frequency spectrum of the interferometric signal detected from scatterers undergoing periodic motion in response to an applied stimulus. We present quantitative results of sub-micron excitation at 820 Hz in a layered phantom and the first such measurements in human skin in vivo.

Audio frequency in vivo optical coherence elastography

International Nuclear Information System (INIS)

Adie, Steven G; Kennedy, Brendan F; Armstrong, Julian J; Alexandrov, Sergey A; Sampson, David D

2009-01-01

We present a new approach to optical coherence elastography (OCE), which probes the local elastic properties of tissue by using optical coherence tomography to measure the effect of an applied stimulus in the audio frequency range. We describe the approach, based on analysis of the Bessel frequency spectrum of the interferometric signal detected from scatterers undergoing periodic motion in response to an applied stimulus. We present quantitative results of sub-micron excitation at 820 Hz in a layered phantom and the first such measurements in human skin in vivo.

Optical Coherence Tomography Technology and Quality Improvement Methods for Optical Coherence Tomography Images of Skin: A Short Review

Science.gov (United States)

Adabi, Saba; Turani, Zahra; Fatemizadeh, Emad; Clayton, Anne; Nasiriavanaki, Mohammadreza

2017-01-01

Optical coherence tomography (OCT) delivers 3-dimensional images of tissue microstructures. Although OCT imaging offers a promising high-resolution method, OCT images experience some artifacts that lead to misapprehension of tissue structures. Speckle, intensity decay, and blurring are 3 major artifacts in OCT images. Speckle is due to the low coherent light source used in the configuration of OCT. Intensity decay is a deterioration of light with respect to depth, and blurring is the consequence of deficiencies of optical components. In this short review, we summarize some of the image enhancement algorithms for OCT images which address the abovementioned artifacts. PMID:28638245

Optical Coherence Tomography Technology and Quality Improvement Methods for Optical Coherence Tomography Images of Skin: A Short Review

Directory of Open Access Journals (Sweden)

Saba Adabi

2017-06-01

Full Text Available Optical coherence tomography (OCT delivers 3-dimensional images of tissue microstructures. Although OCT imaging offers a promising high-resolution method, OCT images experience some artifacts that lead to misapprehension of tissue structures. Speckle, intensity decay, and blurring are 3 major artifacts in OCT images. Speckle is due to the low coherent light source used in the configuration of OCT. Intensity decay is a deterioration of light with respect to depth, and blurring is the consequence of deficiencies of optical components. In this short review, we summarize some of the image enhancement algorithms for OCT images which address the abovementioned artifacts.

Spectral-domain optical coherence tomography staging and autofluorescence imaging in achromatopsia.

Science.gov (United States)

Greenberg, Jonathan P; Sherman, Jerome; Zweifel, Sandrine A; Chen, Royce W S; Duncker, Tobias; Kohl, Susanne; Baumann, Britta; Wissinger, Bernd; Yannuzzi, Lawrence A; Tsang, Stephen H

2014-04-01

IMPORTANCE Evidence is mounting that achromatopsia is a progressive retinal degeneration, and treatments for this condition are on the horizon. OBJECTIVES To categorize achromatopsia into clinically identifiable stages using spectral-domain optical coherence tomography and to describe fundus autofluorescence imaging in this condition. DESIGN, SETTING, AND PARTICIPANTS A prospective observational study was performed between 2010 and 2012 at the Edward S. Harkness Eye Institute, New York-Presbyterian Hospital. Participants included 17 patients (aged 10-62 years) with full-field electroretinography-confirmed achromatopsia. MAIN OUTCOMES AND MEASURES Spectral-domain optical coherence tomography features and staging system, fundus autofluorescence and near-infrared reflectance features and their correlation to optical coherence tomography, and genetic mutations served as the outcomes and measures. RESULTS Achromatopsia was categorized into 5 stages on spectral-domain optical coherence tomography: stage 1 (2 patients [12%]), intact outer retina; stage 2 (2 patients [12%]), inner segment ellipsoid line disruption; stage 3 (5 patients [29%]), presence of an optically empty space; stage 4 (5 patients [29%]), optically empty space with partial retinal pigment epithelium disruption; and stage 5 (3 patients [18%]), complete retinal pigment epithelium disruption and/or loss of the outer nuclear layer. Stage 1 patients showed isolated hyperreflectivity of the external limiting membrane in the fovea, and the external limiting membrane was hyperreflective above each optically empty space. On near infrared reflectance imaging, the fovea was normal, hyporeflective, or showed both hyporeflective and hyperreflective features. All patients demonstrated autofluorescence abnormalities in the fovea and/or parafovea: 9 participants (53%) had reduced or absent autofluorescence surrounded by increased autofluorescence, 4 individuals (24%) showed only reduced or absent autofluorescence, 3

Bandwidth scalable, coherent transmitter based on the parallel synthesis of multiple spectral slices using optical arbitrary waveform generation.

Science.gov (United States)

Geisler, David J; Fontaine, Nicolas K; Scott, Ryan P; He, Tingting; Paraschis, Loukas; Gerstel, Ori; Heritage, Jonathan P; Yoo, S J B

2011-04-25

We demonstrate an optical transmitter based on dynamic optical arbitrary waveform generation (OAWG) which is capable of creating high-bandwidth (THz) data waveforms in any modulation format using the parallel synthesis of multiple coherent spectral slices. As an initial demonstration, the transmitter uses only 5.5 GHz of electrical bandwidth and two 10-GHz-wide spectral slices to create 100-ns duration, 20-GHz optical waveforms in various modulation formats including differential phase-shift keying (DPSK), quaternary phase-shift keying (QPSK), and eight phase-shift keying (8PSK) with only changes in software. The experimentally generated waveforms showed clear eye openings and separated constellation points when measured using a real-time digital coherent receiver. Bit-error-rate (BER) performance analysis resulted in a BER < 9.8 × 10(-6) for DPSK and QPSK waveforms. Additionally, we experimentally demonstrate three-slice, 4-ns long waveforms that highlight the bandwidth scalable nature of the optical transmitter. The various generated waveforms show that the key transmitter properties (i.e., packet length, modulation format, data rate, and modulation filter shape) are software definable, and that the optical transmitter is capable of acting as a flexible bandwidth transmitter.

Phase resolved and coherence gated en face reflection imaging of multilayered embryonal carcinoma cells

Science.gov (United States)

Yamauchi, Toyohiko; Fukami, Tadashi; Iwai, Hidenao; Yamashita, Yutaka

2012-03-01

Embryonal carcinoma (EC) cells, which are cell lines derived from teratocarcinomas, have characteristics in common with stem cells and differentiate into many kinds of functional cells. Similar to embryonic stem (ES) cells, undifferentiated EC cells form multi-layered spheroids. In order to visualize the three-dimensional structure of multilayered EC cells without labeling, we employed full-field interference microscopy with the aid of a low-coherence quantitative phase microscope, which is a reflection-type interference microscope employing the digital holographic technique with a low-coherent light source. Owing to the low-coherency of the light-source (halogen lamp), only the light reflected from reflective surface at a specific sectioning height generates an interference image on the CCD camera. P19CL6 EC cells, derived from mouse teratocarcinomas, formed spheroids that are about 50 to 200 micrometers in diameter. Since the height of each cell is around 10 micrometers, it is assumed that each spheroid has 5 to 20 cell layers. The P19CL6 spheroids were imaged in an upright configuration and the horizontally sectioned reflection images of the sample were obtained by sequentially and vertically scanning the zero-path-length height. Our results show the threedimensional structure of the spheroids, in which plasma and nuclear membranes were distinguishably imaged. The results imply that our technique is further capable of imaging induced pluripotent stem (iPS) cells for the assessment of cell properties including their pluripotency.

Measurement of ciliary beat frequency using Doppler optical coherence tomography.

Science.gov (United States)

Lemieux, Bryan T; Chen, Jason J; Jing, Joseph; Chen, Zhongping; Wong, Brian J F

2015-11-01

Measuring ciliary beat frequency (CBF) is a technical challenge and difficult to perform in vivo. Doppler optical coherence tomography (D-OCT) is a mesoscopic noncontact imaging modality that provides high-resolution tomographic images and detects micromotion simultaneously in living tissues. In this work we used D-OCT to measure CBF in ex vivo tissue as the first step toward translating this technology to clinical use. Fresh ex vivo samples of rabbit tracheal mucosa were imaged using both D-OCT and phase-contrast microscopy (n = 5). The D-OCT system was designed and built to specification in our lab (1310-nm swept source vertical-cavity surface-emitting laser [VCSEL], 6-μm axial resolution). The samples were placed in culture and incubated at 37°C. A fast Fourier transform was performed on the D-OCT signal recorded on the surface of the samples to gauge CBF. High-speed digital video of the epithelium recorded via phase-contrast microscopy was analyzed to confirm the CBF measurements. The D-OCT system detected Doppler signal at the epithelial layer of ex vivo rabbit tracheal samples suggestive of ciliary motion. CBF was measured at 9.36 ± 1.22 Hz using D-OCT and 9.08 ± 0.48 Hz using phase-contrast microscopy. No significant differences were found between the 2 methods (p > 0.05). D-OCT allows for the quantitative measurement of CBF without the need to resolve individual cilia. Furthermore, D-OCT technology can be incorporated into endoscopic platforms that allow clinicians to readily measure CBF in the office and provide a direct measurement of mucosal health. © 2015 ARS-AAOA, LLC.

Machine learning concepts in coherent optical communication systems

DEFF Research Database (Denmark)

Zibar, Darko; Schäffer, Christian G.

2014-01-01

Powerful statistical signal processing methods, used by the machine learning community, are addressed and linked to current problems in coherent optical communication. Bayesian filtering methods are presented and applied for nonlinear dynamic state tracking. © 2014 OSA.......Powerful statistical signal processing methods, used by the machine learning community, are addressed and linked to current problems in coherent optical communication. Bayesian filtering methods are presented and applied for nonlinear dynamic state tracking. © 2014 OSA....

Strain Wave Acquisition by a Fiber Optic Coherent Sensor for Impact Monitoring.

Science.gov (United States)

Sbarufatti, Claudio; Beligni, Alessio; Gilioli, Andrea; Ferrario, Maddalena; Mattarei, Marco; Martinelli, Mario; Giglio, Marco

2017-07-13

A novel fiber optic sensing technology for high frequency dynamics detection is proposed in this paper, specifically tailored for structural health monitoring applications based on strain wave analysis, for both passive impact identification and active Lamb wave monitoring. The sensing solution relies on a fiber optic-based interferometric architecture associated to an innovative coherent detection scheme, which retrieves in a completely passive way the high-frequency phase information of the received optical signal. The sensing fiber can be arranged into different layouts, depending on the requirement of the specific application, in order to enhance the sensor sensitivity while still ensuring a limited gauge length if punctual measures are required. For active Lamb wave monitoring, this results in a sensing fiber arranged in multiple loops glued on an aluminum thin panel in order to increase the phase signal only in correspondence to the sensing points of interest. Instead, for passive impact identification, the required sensitivity is guaranteed by simply exploiting a longer gauge length glued to the structure. The fiber optic coherent (FOC) sensor is exploited to detect the strain waves emitted by a piezoelectric transducer placed on the aluminum panel or generated by an impulse hammer, respectively. The FOC sensor measurements have been compared with both a numerical model based on Finite Elements and traditional piezoelectric sensors, confirming a good agreement between experimental and simulated results for both active and passive impact monitoring scenarios.

Optical technologies for extreme-ultraviolet and soft X-ray coherent sources

International Nuclear Information System (INIS)

Canova, Federico; Poletto, Luca

2015-01-01

The book reviews the most recent achievements in optical technologies for XUV and X-ray coherent sources. Particular attention is given to free-electron-laser facilities, but also to other sources available at present, such as synchrotrons, high-order laser harmonics and X-ray lasers. The optical technologies relevant to each type of source are discussed. In addition, the main technologies used for photon handling and conditioning, namely multilayer mirrors, adaptive optics, crystals and gratings are explained. Experiments using coherent light received during the last decades a lot of attention for the X-ray regime. Strong efforts were taken for the realization of almost fully coherent sources, e.g. the free-electron lasers, both as independent sources in the femtosecond and attosecond regimes and as seeding sources for free-electron-lasers and X-ray gas lasers. In parallel to the development of sources, optical technologies for photon handling and conditioning of such coherent and intense X-ray beams advanced. New problems were faced for the realization of optical components of beamlines demanding to manage coherent X-ray photons, e.g. the preservation of coherence and time structure of ultra short pulses.

In-line optical fiber metallic mirror reflector for monolithic common path optical coherence tomography probes.

Science.gov (United States)

Singh, Kanwarpal; Reddy, Rohith; Sharma, Gargi; Verma, Yogesh; Gardecki, Joseph A; Tearney, Guillermo

2018-03-01

Endoscopic optical coherence tomography probes suffer from various artifacts due to dispersion imbalance and polarization mismatch between reference and sample arm light. Such artifacts can be minimized using a common path approach. In this work, we demonstrate a miniaturized common path probe for optical coherence tomography using an inline fiber mirror. A common path optical fiber probe suitable for performing high-resolution endoscopic optical coherence tomography imaging was developed. To achieve common path functionality, an inline fiber mirror was fabricated using a thin gold layer. A commercially available swept source engine was used to test the designed probe in a cadaver human coronary artery ex vivo. We achieved a sensitivity of 104 dB for this probe using a swept source optical coherence tomography system. To test the probe, images of a cadaver human coronary artery were obtained, demonstrating the quality that is comparable to those obtained by OCT systems with separate reference arms. Additionally, we demonstrate recovery of ranging depth by use of a Michelson interferometer in the detection path. We developed a miniaturized monolithic inline fiber mirror-based common path probe for optical coherence tomography. Owing to its simplicity, our design will be helpful in endoscopic applications that require high-resolution probes in a compact form factor while reducing system complexity. Lasers Surg. Med. 50:230-235, 2018. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

Optical generation and control of quantum coherence in semiconductor nanostructures

CERN Document Server

Slavcheva, Gabriela

2010-01-01

The unprecedented control of coherence that can be exercised in quantum optics of atoms and molecules has stimulated increasing efforts in extending it to solid-state systems. One motivation to exploit the coherent phenomena comes from the emergence of the quantum information paradigm, however many more potential device applications ranging from novel lasers to spintronics are all bound up with issues in coherence. The book focuses on recent advances in the optical control of coherence in excitonic and polaritonic systems as model systems for the complex semiconductor dynamics towards the goal

Coherent gigahertz phonons in Ge₂Sb₂Te₅ phase-change materials.

Science.gov (United States)

Hase, Muneaki; Fons, Paul; Kolobov, Alexander V; Tominaga, Junji

2015-12-09

Using ≈40 fs ultrashort laser pulses, we investigate the picosecond acoustic response from a prototypical phase change material, thin Ge2Sb2Te5 (GST) films with various thicknesses. After excitation with a 1.53 eV-energy pulse with a fluence of ≈5 mJ cm(-2), the time-resolved reflectivity change exhibits transient electronic response, followed by a combination of exponential-like strain and coherent acoustic phonons in the gigahertz (GHz) frequency range. The time-domain shape of the coherent acoustic pulse is well reproduced by the use of the strain model by Thomsen et al 1986 (Phys. Rev. B 34 4129). We found that the decay rate (the inverse of the relaxation time) of the acoustic phonon both in the amorphous and in the crystalline phases decreases as the film thickness increases. The thickness dependence of the acoustic phonon decay is well modeled based on both phonon-defect scattering and acoustic phonon attenuation at the GST/Si interface, and it is revealed that those scattering and attenuation are larger in crystalline GST films than those in amorphous GST films.

Depth-resolved multilayer pigment identification in paintings: combined use of laser-induced breakdown spectroscopy (LIBS) and optical coherence tomography (OCT).

Science.gov (United States)

Kaszewska, Ewa A; Sylwestrzak, Marcin; Marczak, Jan; Skrzeczanowski, Wojciech; Iwanicka, Magdalena; Szmit-Naud, Elżbieta; Anglos, Demetrios; Targowski, Piotr

2013-08-01

A detailed feasibility study on the combined use of laser-induced breakdown spectroscopy with optical coherence tomography (LIBS/OCT), aiming at a realistic depth-resolved elemental analysis of multilayer stratigraphies in paintings, is presented. Merging a high spectral resolution LIBS system with a high spatial resolution spectral OCT instrument significantly enhances the quality and accuracy of stratigraphic analysis. First, OCT mapping is employed prior to LIBS analysis in order to assist the selection of specific areas of interest on the painting surface to be examined in detail. Then, intertwined with LIBS, the OCT instrument is used as a precise profilometer for the online determination of the depth of the ablation crater formed by individual laser pulses during LIBS depth-profile analysis. This approach is novel and enables (i) the precise in-depth scaling of elemental concentration profiles, and (ii) the recognition of layer boundaries by estimating the corresponding differences in material ablation rate. Additionally, the latter is supported, within the transparency of the object, by analysis of the OCT cross-sectional views. The potential of this method is illustrated by presenting results on the detailed analysis of the structure of an historic painting on canvas performed to aid planned restoration of the artwork.

INTRASURGICAL MICROSCOPE-INTEGRATED SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY-ASSISTED MEMBRANE PEELING.

Science.gov (United States)

Falkner-Radler, Christiane I; Glittenberg, Carl; Gabriel, Max; Binder, Susanne

2015-10-01

To evaluate microscope-integrated intrasurgical spectral domain optical coherence tomography during macular surgery in a prospective monocenter study. Before pars plana vitrectomy and before, during, and after membrane peeling, 512 × 128 macular cube scans were performed using a Carl Zeiss Meditec Cirrus high-definition OCT system adapted to the optical pathway of a Zeiss OPMI VISU 200 surgical microscope and compared with retinal staining. The study included 51 patients with epiretinal membranes, with 8 of those having additional lamellar macular holes, 11 patients with vitreomacular traction, and 8 patients with full-thickness macular holes. Intraoperative spectral domain optical coherence tomography allowed performing membrane peeling without using retinal dyes in 40% of cases (28 of 70 patients). No residual membranes were found in 94.3% of patients (66 of 70 patients) in intrasurgical spectral domain optical coherence tomography and subsequent (re)staining. In patients with vitreomacular traction, intrasurgical spectral domain optical coherence tomography scans facilitated decisions on the need for an intraocular tamponade after membrane peeling. Intraoperative spectral domain optical coherence tomography was comparable with retinal dyes in confirming success after membrane peeling. However, the visualization of flat membranes was better after staining.

Interference electron microscopy of one-dimensional electron-optical phase objects

International Nuclear Information System (INIS)

Fazzini, P.F.; Ortolani, L.; Pozzi, G.; Ubaldi, F.

2006-01-01

The application of interference electron microscopy to the investigation of electron optical one-dimensional phase objects like reverse biased p-n junctions and ferromagnetic domain walls is considered. In particular the influence of diffraction from the biprism edges on the interference images is analyzed and the range of applicability of the geometric optical equation for the interpretation of the interference fringe shifts assessed by comparing geometric optical images with full wave-optical simulations. Finally, the inclusion of partial spatial coherence effects are discussed

Gaussian cloning of coherent states with known phases

International Nuclear Information System (INIS)

Alexanian, Moorad

2006-01-01

The fidelity for cloning coherent states is improved over that provided by optimal Gaussian and non-Gaussian cloners for the subset of coherent states that are prepared with known phases. Gaussian quantum cloning duplicates all coherent states with an optimal fidelity of 2/3. Non-Gaussian cloners give optimal single-clone fidelity for a symmetric 1-to-2 cloner of 0.6826. Coherent states that have known phases can be cloned with a fidelity of 4/5. The latter is realized by a combination of two beam splitters and a four-wave mixer operated in the nonlinear regime, all of which are realized by interaction Hamiltonians that are quadratic in the photon operators. Therefore, the known Gaussian devices for cloning coherent states are extended when cloning coherent states with known phases by considering a nonbalanced beam splitter at the input side of the amplifier

Tunable optical setup with high flexibility for spectrally resolved coherent anti-Stokes Raman scattering microscopy

International Nuclear Information System (INIS)

Bergner, G; Akimov, D; Bartelt, H; Dietzek, B; Popp, J; Schlücker, S

2011-01-01

A simplified setup for coherent anti-Stokes Raman scattering (CARS) microscopy is introduced, which allows for recording CARS images with 30 cm -1 excitation bandwidth for probing Raman bands between 500 and 900 cm -1 with minimal requirements for alignment. The experimental arrangement is based on electronic switching between CARS images recorded at different Raman resonances by combining a photonic crystal fiber (PCF) as broadband light source and an acousto-optical programmable dispersive filter (AOPDF) as tunable wavelength filter. Such spatial light modulator enables selection of a narrow-band spectrum to yield high vibrational contrast and hence chemical contrast in the resultant CARS images. Furthermore, an experimental approach to reconstruct spectral information from CARS image contrast is introduced

Optical coherence tomography of basal cell carcinoma

DEFF Research Database (Denmark)

Yücel, D.; Themstrup, L.; Manfredi, Maddalena

2016-01-01

Background: Basal cell carcinoma (BCC) is the most prevalent malignancy in Caucasians. Optical coherence tomography (OCT) is a non-invasive optical imaging technology using the principle of interferometry. OCT has shown a great potential in diagnosing, monitoring, and follow-up of BCC. So far most...

Improved ultrashort pulse-retrieval algorithm for frequency-resolved optical gating

International Nuclear Information System (INIS)

DeLong, K.W.; Trebino, R.

1994-01-01

We report on significant improvements in the pulse-retrieval algorithm used to reconstruct the amplitude and the phase of ultrashort optical pulses from the experimental frequency-resolved optical gating trace data in the polarization-gate geometry. These improvements involve the use of an intensity constraint, an overcorrection technique, and a multidimensional minimization scheme. While the previously published, basic algorithm converged for most common ultrashort pulses, it failed to retrieve pulses with significant intensity substructure. The improved composite algorithm successfully converges for such pulses. It can now retrieve essentially all pulses of practical interest. We present examples of complex waveforms that were retrieved by the improved algorithm

Measurement of the temperature dependence of Young's modulus of cartilage by phase-sensitive optical coherence elastography

Energy Technology Data Exchange (ETDEWEB)

Liu, C H; Li, J; Singh, M; Larin, K V [Department of Biomedical Engineering, University of Houston, Houston, Texas (United States); Skryabina, M N [Department of Physics, M.V. Lomonosov Moscow State University (Russian Federation); Sobol, E N [Institute of Laser and Information Technologies, Russian Academy of Sciences, Troitsk, Moscow Region (Russian Federation)

2014-08-31

The development of an effective system to monitor the changes in the elastic properties of cartilage tissue with increasing temperature in laser reconstruction is an urgent practical task. In this paper, the use of phase-sensitive optical coherence elastography for detection of elastic waves in the sample has allowed Young's modulus of cartilage tissue to be measured directly during heating. Young's modulus was calculated from the group velocity of propagation of elastic waves excited by means of a system supplying focused air pulses. The measurement results are in agreement with the results of measurements of the modulus of elasticity under mechanical compression. The technique developed allows for noninvasive measurements; its development is promising for the use in vivo. (laser biophotonics)

Photoreceptor inner segment ellipsoid band integrity on spectral domain optical coherence tomography

Directory of Open Access Journals (Sweden)

Saxena S

2014-12-01

Full Text Available Sandeep Saxena,1 Khushboo Srivastav,1 Chui M Cheung,2 Joanne YW Ng,3 Timothy YY Lai3 1Retina Service, Department of Ophthalmology, King George’s Medical University Lucknow, India; 2Singapore National Eye Centre, Singapore; 3Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Kowloon, Hong Kong Abstract: Spectral domain optical coherence tomography cross-sectional imaging of the macula has conventionally been resolved into four bands. However, some doubts were raised regarding authentication of the existence of these bands. Recently, a number of studies have suggested that the second band appeared to originate from the inner segment ellipsoids of the foveal cone photoreceptors, and therefore the previously called inner segment-outer segment junction is now referred to as inner segment ellipsoidband. Photoreceptor dysfunction may be a significant predictor of visual acuity in a spectrum of surgical and medical retinal diseases. This review aims to provide an overview and summarizes the role of the photoreceptor inner segment ellipsoid band in the management and prognostication of various vitreoretinal diseases. Keywords: spectral domain optical coherence tomography, inner segment-outer segment junction, external limiting membrane, macular hole, diabetic macular edema, age relate macular degeneration

Probing molecular chirality by coherent optical absorption spectra

Energy Technology Data Exchange (ETDEWEB)

Jia, W. Z. [Quantum Optoelectronics Laboratory, School of Physics and Technology, Southwest Jiaotong University, Chengdu 610031 (China); Wei, L. F. [Quantum Optoelectronics Laboratory, School of Physics and Technology, Southwest Jiaotong University, Chengdu 610031 (China); State Key Laboratory of Optoelectronic Materials and Technologies, School of Physics and Engineering, Sun Yat-Sen University, Guangzhou 510275 (China)

2011-11-15

We propose an approach to sensitively probe the chirality of molecules by measuring their coherent optical-absorption spectra. It is shown that quantum dynamics of the cyclic three-level chiral molecules driven by appropriately designed external fields is total-phase dependent. This will result in chirality-dependent absorption spectra for the probe field. As a consequence, the charality-dependent information in the spectra (such as the locations and relative heights of the characteristic absorption peaks) can be utilized to identify molecular chirality and determinate enantiomer excess (i.e., the percentages of different enantiomers). The feasibility of the proposal with chiral molecules confined in hollow-core photonic crystal fiber is also discussed.

The Development, Commercialization, and Impact of Optical Coherence Tomography.

Science.gov (United States)

Fujimoto, James; Swanson, Eric

2016-07-01

This review was written for the special issue of IOVS to describe the history of optical coherence tomography (OCT) and its evolution from a nonscientific, historic perspective. Optical coherence tomography has become a standard of care in ophthalmology, providing real-time information on structure and function - diagnosing disease, evaluating progression, and assessing response to therapy, as well as helping to understand disease pathogenesis and create new therapies. Optical coherence tomography also has applications in multiple clinical specialties, fundamental research, and manufacturing. We review the early history of OCT describing how research and development evolves and the important role of multidisciplinary collaboration and expertise. Optical coherence tomography had its origin in femtosecond optics, but used optical communications technologies and required advanced engineering for early OCT prototypes, clinical feasibility studies, entrepreneurship, and corporate development in order to achieve clinical acceptance and clinical impact. Critical advances were made by early career researchers, clinician scientists, engineering experts, and business leaders, which enabled OCT to have a worldwide impact on health care. We introduce the concept of an "ecosystem" consisting of research, government funding, collaboration and competition, clinical studies, innovation, entrepreneurship and industry, and impact - all of which must work synergistically. The process that we recount is long and challenging, but it is our hope that it might inspire early career professionals in science, engineering, and medicine, and that the clinical and research community will find this review of interest.

The Development, Commercialization, and Impact of Optical Coherence Tomography

Science.gov (United States)

Fujimoto, James; Swanson, Eric

2016-01-01

This review was written for the special issue of IOVS to describe the history of optical coherence tomography (OCT) and its evolution from a nonscientific, historic perspective. Optical coherence tomography has become a standard of care in ophthalmology, providing real-time information on structure and function – diagnosing disease, evaluating progression, and assessing response to therapy, as well as helping to understand disease pathogenesis and create new therapies. Optical coherence tomography also has applications in multiple clinical specialties, fundamental research, and manufacturing. We review the early history of OCT describing how research and development evolves and the important role of multidisciplinary collaboration and expertise. Optical coherence tomography had its origin in femtosecond optics, but used optical communications technologies and required advanced engineering for early OCT prototypes, clinical feasibility studies, entrepreneurship, and corporate development in order to achieve clinical acceptance and clinical impact. Critical advances were made by early career researchers, clinician scientists, engineering experts, and business leaders, which enabled OCT to have a worldwide impact on health care. We introduce the concept of an “ecosystem” consisting of research, government funding, collaboration and competition, clinical studies, innovation, entrepreneurship and industry, and impact – all of which must work synergistically. The process that we recount is long and challenging, but it is our hope that it might inspire early career professionals in science, engineering, and medicine, and that the clinical and research community will find this review of interest. PMID:27409459

Erbium-based optical coherent transient correlator for the 1.5-micron communication bands

Science.gov (United States)

Harris, Todd Louis

2001-08-01

Correlators are needed in communications, memory, and signal processing applications to perform cross- correlations for tasks such as address-header decoding for data-packet switching, spread spectrum and code division multiple access communication, associative memory, database searching, and pattern recognition. Correlators based on optical coherent transients, Fourier theory, and holography can potentially perform real-time correlations with multi-phase encoded information at gigahertz bandwidths, a capability conventional electronics lack. The first operation of spatial-spectral holographic correlators in the 1.5-gm communication bands was demonstrated at 1536 nm using Er3+:Y 2SiO5 and the correlator processed multi-phase encoded optical pulses. Real-time decoding of 20-bit binary-phase-shift key encoded address-header pulses is demonstrated using stimulated photon echoes in a phase-matched crossed-beam configuration; this function is required for coherent transient optical data routing and packet switching. Optical 30-symbol quadriphase-shift keyed (QPSK) and binary-phase-shift keyed (BPSK) codes were processed, and the results demonstrated the ability of such correlators to process QPSK codes and BPSK codes with the same apparatus. The high-fidelity correlations exhibit the low sidelobe characteristics expected for the codes used. The 4I15/2 and 4I13/2 crystal field levels of 0.005% Er3+:Y2O3 were measured by absorption and laser excited fluorescence on oriented samples. Site selective fluorescence distinguished transitions of Er3+ in crystallographic sites of C2 and C3i symmetry. The paramagnetic g-tensors for ions in sites of C2 symmetry were measured by orientation dependent Zeeman absorption spectroscopy. For the lowest crystal field level of 4I15/2 the g-tensor principal x-axis in the (100) plane is tipped +2.06° from [001] and principal g-values are: gz = 11.93, gx = 1.603, and gy = 4.711. For the lowest crystal field level of 4I13/2 the g

Optical coherence elastography assesses tissue modifications in laser reshaping of cornea and cartilages

Science.gov (United States)

Zaitsev, V. Y.; Matveyev, A. L.; Matveev, L. A.; Gelikonov, G. V.; Omelchenko, A. I.; Shabanov, D. V.; Sovetsky, A. A.; Baum, O. I.; Vitkin, A.; Sobol, E. N.

2018-02-01

Non-surgical thermo-mechanical reshaping of avascular collagenous tissues (cartilages and cornea) using moderate heating by IR-laser irradiation is an emerging technology that can find important applications in visioncorrection problems and preparation of cartilaginous implants in otolaryngology. To estimate both transient interframe strains and cumulative resultant strains produced by the laser irradiation of the tissue we use and improved version of strain mapping developed in our previous work related to compressional phase-sensitive optical coherence tomography. To reveal microstructural changes in the tissue regions where irradiation-produced strains do not disappear after temperature equilibration, we apply compressional optical coherence elastography in order to visualize the resultant variations in the tissue stiffness. The so-found regions of the stiffness reduction are attributed to formation of microscopic pores, existence of which agree with independent data obtained using methods of high-resolution microscopy.

Towards phase-coherent caloritronics in superconducting circuits

Science.gov (United States)

Fornieri, Antonio; Giazotto, Francesco

2017-10-01

The emerging field of phase-coherent caloritronics (from the Latin word calor, heat) is based on the possibility of controlling heat currents by using the phase difference of the superconducting order parameter. The goal is to design and implement thermal devices that can control energy transfer with a degree of accuracy approaching that reached for charge transport by contemporary electronic components. This can be done by making use of the macroscopic quantum coherence intrinsic to superconducting condensates, which manifests itself through the Josephson effect and the proximity effect. Here, we review recent experimental results obtained in the realization of heat interferometers and thermal rectifiers, and discuss a few proposals for exotic nonlinear phase-coherent caloritronic devices, such as thermal transistors, solid-state memories, phase-coherent heat splitters, microwave refrigerators, thermal engines and heat valves. Besides being attractive from the fundamental physics point of view, these systems are expected to have a vast impact on many cryogenic microcircuits requiring energy management, and possibly lay the first stone for the foundation of electronic thermal logic.

Development of a phase-sensitive Fourier domain optical coherence tomography system to measure mouse organ of Corti vibrations in two cochlear turns

Energy Technology Data Exchange (ETDEWEB)

Ramamoorthy, Sripriya [Oregon Hearing Research Center, Oregon Health & Science University, Portland, Oregon (United States); Zhang, Yuan; Jacques, Steven [Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon (United States); Petrie, Tracy; Wang, Ruikang [Department of Bioengineering, University of Washington, Seattle, Washington (United States); Nuttall, Alfred L. [Oregon Hearing Research Center, Oregon Health & Science University, Portland, Oregon (United States); Kresge Hearing Research Institute, The University of Michigan, Ann Arbor, Michigan (United States)

2015-12-31

In this study, we have developed a phase-sensitive Fourier-domain optical coherence tomography system to simultaneously measure the in vivo inner ear vibrations in the hook area and second turn of the mouse cochlea. This technical development will enable measurement of intra-cochlear distortion products at ideal locations such as the distortion product generation site and reflection site. This information is necessary to un-mix the complex mixture of intra-cochlear waves comprising the DPOAE and thus leads to the non-invasive identification of the local region of cochlear damage.

Characterization of dynamic physiology of the bladder by optical coherence tomography

Science.gov (United States)

Yuan, Zhijia; Keng, Kerri; Pan, Rubin; Ren, Hugang; Du, Congwu; Kim, Jason; Pan, Yingtian

2012-03-01

Because of its high spatial resolution and noninvasive imaging capabilities, optical coherence tomography has been used to characterize the morphological details of various biological tissues including urinary bladder and to diagnose their alternations (e.g., cancers). In addition to static morphology, the dynamic features of tissue morphology can provide important information that can be used to diagnose the physiological and functional characteristics of biological tissues. Here, we present the imaging studies based on optical coherence tomography to characterize motion related physiology and functions of rat bladder detrusor muscles and compared the results with traditional biomechanical measurements. Our results suggest that optical coherence tomography is capable of providing quantitative evaluation of contractile functions of intact bladder (without removing bladder epithelium and connective tissue), which is potentially of more clinical relevance for future clinical diagnosis - if incorporated with cystoscopic optical coherence tomography.

Optical Coherence Tomography Angiography: Employing a Novel Technique for Investigation in Vogt-Koyanagi-Harada Disease.

Science.gov (United States)

Giannakouras, Panagiotis; Andreanos, Konstantinos; Giavi, Barbara; Diagourtas, Andreas

2017-01-01

To report a case of Vogt-Koyanagi-Harada (VKH) disease and describe the imaging findings by means of optical coherence tomography angiography (OCTA). Medical and ophthalmological history, ophthalmological examination, laboratory evaluation, B-scan ultrasonography, fluorescein and indocyanine angiography, and optical coherence tomography (OCT) were performed at baseline, as well as OCTA. A 50-year-old healthy female presented with decreased vision in both eyes. A Topcon DRI OCT Triton Plus swept source OCT system was used to visualize and evaluate the retinal and choroidal vascular plexus. Patchy and confluent dark areas in the superficial and deep retinal capillary plexus and choriocapillaris corresponded to areas of hypoperfusion, analyzed as areas of ischemia. VKH disease is characterized by ocular, neurological, and integumentary findings in its complete form. We present a case of incomplete disease in a 50-year-old female evaluated by means of OCTA which is a novel technique that provides depth-resolved images of the retina and choroidal microvasculature without dye injection that allows better visualization and detailed evaluation of the retinal and choroidal vascular plexus.

The effect of jitter on the performance of space coherent optical communication system with Costas loop

Science.gov (United States)

Li, Xin; Hong, Yifeng; Wang, Jinfang; Liu, Yang; Sun, Xun; Li, Mi

2018-01-01

Numerous communication techniques and optical devices successfully applied in space optical communication system indicates a good portability of it. With this good portability, typical coherent demodulation technique of Costas loop can be easily adopted in space optical communication system. As one of the components of pointing error, the effect of jitter plays an important role in the communication quality of such system. Here, we obtain the probability density functions (PDF) of different jitter degrees and explain their essential effect on the bit error rate (BER) space optical communication system. Also, under the effect of jitter, we research the bit error rate of space coherent optical communication system using Costas loop with different system parameters of transmission power, divergence angle, receiving diameter, avalanche photodiode (APD) gain, and phase deviation caused by Costas loop. Through a numerical simulation of this kind of communication system, we demonstrate the relationship between the BER and these system parameters, and some corresponding methods of system optimization are presented to enhance the communication quality.

Spectroscopic Doppler analysis for visible-light optical coherence tomography

Science.gov (United States)

Shu, Xiao; Liu, Wenzhong; Duan, Lian; Zhang, Hao F.

2017-12-01

Retinal oxygen metabolic rate can be effectively measured by visible-light optical coherence tomography (vis-OCT), which simultaneously quantifies oxygen saturation and blood flow rate in retinal vessels through spectroscopic analysis and Doppler measurement, respectively. Doppler OCT relates phase variation between sequential A-lines to the axial flow velocity of the scattering medium. The detectable phase shift is between -π and π due to its periodicity, which limits the maximum measurable unambiguous velocity without phase unwrapping. Using shorter wavelengths, vis-OCT is more vulnerable to phase ambiguity since flow induced phase variation is linearly related to the center wavenumber of the probing light. We eliminated the need for phase unwrapping using spectroscopic Doppler analysis. We split the whole vis-OCT spectrum into a series of narrow subbands and reconstructed vis-OCT images to extract corresponding Doppler phase shifts in all the subbands. Then, we quantified flow velocity by analyzing subband-dependent phase shift using linear regression. In the phantom experiment, we showed that spectroscopic Doppler analysis extended the measurable absolute phase shift range without conducting phase unwrapping. We also tested this method to quantify retinal blood flow in rodents in vivo.

[Evaluation of diabetic microangiopathy using optical coherence tomography angiography].

Science.gov (United States)

Czakó, Cecília; Sándor, Gábor László; Ecsedy, Mónika; Szepessy, Zsuzsanna; Borbándy, Ágnes; Resch, Miklós; Papp, András; Récsán, Zsuzsa; Horváth, Hajnalka; Nagy, Zoltán Zsolt; Kovács, Illés

2018-02-01

Optical coherence tomography angiography is a non-invasive imaging technique that is able to visualize the different retinal vascular layers using motion contrast to detect blood flow without intravenous dye injection. This method might help to assess microangiopathy in diabetic retinopathy during screening and follow-up. To quantify retinal microvasculature alterations in both eyes of diabetic patients in relation to systemic risk factors using optical coherence tomography angiography. Both eyes of 36 diabetic patients and 45 individuals without diabetes were examined. Duration of diabetes, insulin therapy, blood pressure, HbA 1c , dyslipidemia, axial length and the presence of diabetic retinopathy were recorded. Retinal vessel density was measured by optical coherence tomography angiography. The effect of risk factors on vessel density and between-eye asymmetry was assessed using multivariable regression analysis. Vessel density was significantly lower and between-eye difference was significantly higher in diabetic patients compared to controls (pdiabetes duration (pdiabetic retinopathy compared to control subjects (pdiabetes compared to healthy subjects. By using optical coherence tomography angiography, the detection of these microvascular alterations is possible before clinically detectable diabetic retinopathy and might serve as a useful tool in both screening and timing of treatment. Orv Hetil. 2018; 159(8): 320-326.

Optical biopsy of lymph node morphology using optical coherence tomography.

Science.gov (United States)

Luo, Wei; Nguyen, Freddy T; Zysk, Adam M; Ralston, Tyler S; Brockenbrough, John; Marks, Daniel L; Oldenburg, Amy L; Boppart, Stephen A

2005-10-01

Optical diagnostic imaging techniques are increasingly being used in the clinical environment, allowing for improved screening and diagnosis while minimizing the number of invasive procedures. Diffuse optical tomography, for example, is capable of whole-breast imaging and is being developed as an alternative to traditional X-ray mammography. While this may eventually be a very effective screening method, other optical techniques are better suited for imaging on the cellular and molecular scale. Optical Coherence Tomography (OCT), for instance, is capable of high-resolution cross-sectional imaging of tissue morphology. In a manner analogous to ultrasound imaging except using optics, pulses of near-infrared light are sent into the tissue while coherence-gated reflections are measured interferometrically to form a cross-sectional image of tissue. In this paper we apply OCT techniques for the high-resolution three-dimensional visualization of lymph node morphology. We present the first reported OCT images showing detailed morphological structure and corresponding histological features of lymph nodes from a carcinogen-induced rat mammary tumor model, as well as from a human lymph node containing late stage metastatic disease. The results illustrate the potential for OCT to visualize detailed lymph node structures on the scale of micrometastases and the potential for the detection of metastatic nodal disease intraoperatively.

Practical somewhat-secure quantum somewhat-homomorphic encryption with coherent states

Science.gov (United States)

Tan, Si-Hui; Ouyang, Yingkai; Rohde, Peter P.

2018-04-01

We present a scheme for implementing homomorphic encryption on coherent states encoded using phase-shift keys. The encryption operations require only rotations in phase space, which commute with computations in the code space performed via passive linear optics, and with generalized nonlinear phase operations that are polynomials of the photon-number operator in the code space. This encoding scheme can thus be applied to any computation with coherent-state inputs, and the computation proceeds via a combination of passive linear optics and generalized nonlinear phase operations. An example of such a computation is matrix multiplication, whereby a vector representing coherent-state amplitudes is multiplied by a matrix representing a linear optics network, yielding a new vector of coherent-state amplitudes. By finding an orthogonal partitioning of the support of our encoded states, we quantify the security of our scheme via the indistinguishability of the encrypted code words. While we focus on coherent-state encodings, we expect that this phase-key encoding technique could apply to any continuous-variable computation scheme where the phase-shift operator commutes with the computation.

COHERENT DETECTION FOR SPECTRAL AMPLITUDE-CODED OPTICAL LABEL SWITCHING SYSTEMS

DEFF Research Database (Denmark)

Osadchiy, Alexey Vladimirovich; Tafur Monroy, Idelfonso

2010-01-01

Coherent detection for spectrally encoded optical labels is proposed and experimentally demonstrated for three label tones spectrally spaced at 1 GHz. The proposed method utilizes a frequency swept local oscillator in a coherent receiver supported by digital signal processing for improved...... flexibility and upgradeability while reducing label detection subsystem complexity as compared with the conventional optical autocorrelation based approaches....

Creation of Long-Term Coherent Optical Memory via Controlled Nonlinear Interactions in Bose-Einstein Condensates

International Nuclear Information System (INIS)

Zhang Rui; Garner, Sean R.; Hau, Lene Vestergaard

2009-01-01

A Bose-Einstein condensate confined in an optical dipole trap is used to generate long-term coherent memory for light, and storage times of more than 1 s are observed. Phase coherence of the condensate as well as controlled manipulations of elastic and inelastic atomic scattering processes are utilized to increase the storage fidelity by several orders of magnitude over previous schemes. The results have important applications for creation of long-distance quantum networks and for generation of entangled states of light and matter.

Optical coherence tomography and optical coherence domain reflectometry for deep brain stimulation probe guidance

Science.gov (United States)

Jeon, Sung W.; Shure, Mark A.; Baker, Kenneth B.; Chahlavi, Ali; Hatoum, Nagi; Turbay, Massud; Rollins, Andrew M.; Rezai, Ali R.; Huang, David

2005-04-01

Deep Brain Stimulation (DBS) is FDA-approved for the treatment of Parkinson's disease and essential tremor. Currently, placement of DBS leads is guided through a combination of anatomical targeting and intraoperative microelectrode recordings. The physiological mapping process requires several hours, and each pass of the microelectrode into the brain increases the risk of hemorrhage. Optical Coherence Domain Reflectometry (OCDR) in combination with current methodologies could reduce surgical time and increase accuracy and safety by providing data on structures some distance ahead of the probe. For this preliminary study, we scanned a rat brain in vitro using polarization-insensitive Optical Coherence Tomography (OCT). For accurate measurement of intensity and attenuation, polarization effects arising from tissue birefringence are removed by polarization diversity detection. A fresh rat brain was sectioned along the coronal plane and immersed in a 5 mm cuvette with saline solution. OCT images from a 1294 nm light source showed depth profiles up to 2 mm. Light intensity and attenuation rate distinguished various tissue structures such as hippocampus, cortex, external capsule, internal capsule, and optic tract. Attenuation coefficient is determined by linear fitting of the single scattering regime in averaged A-scans where Beer"s law is applicable. Histology showed very good correlation with OCT images. From the preliminary study using OCT, we conclude that OCDR is a promising approach for guiding DBS probe placement.

Handbook of coherent domain optical methods biomedical diagnostics, environmental and material science

CERN Document Server

2004-01-01

For the first time in one set of books, coherent-domain optical methods are discussed in the framework of various applications, which are characterized by a strong light scattering. A few chapters describe basic research containing the updated results on coherent and polarized light non-destructive interactions with a scattering medium, in particular, diffraction, interference, and speckle formation at multiple scattering. These chapters allow for understanding coherent-domain diagnostic techniques presented in later chapters. A large portion of Volume I is dedicated to analysis of various aspects of optical coherence tomography (OCT) - a very new and growing field of coherent optics. Two chapters on laser scanning confocal microscopy give insight to recent extraordinary results on in vivo imaging and compare the possibilities and achievements of confocol, excitation multiphoton, and OCT microscopy. This two volume reference contains descriptions of holography, interferometry and optical heterodyning techniqu...

Phase coherence induced by correlated disorder.

Science.gov (United States)

Hong, Hyunsuk; O'Keeffe, Kevin P; Strogatz, Steven H

2016-02-01

We consider a mean-field model of coupled phase oscillators with quenched disorder in the coupling strengths and natural frequencies. When these two kinds of disorder are uncorrelated (and when the positive and negative couplings are equal in number and strength), it is known that phase coherence cannot occur and synchronization is absent. Here we explore the effects of correlating the disorder. Specifically, we assume that any given oscillator either attracts or repels all the others, and that the sign of the interaction is deterministically correlated with the given oscillator's natural frequency. For symmetrically correlated disorder with zero mean, we find that the system spontaneously synchronizes, once the width of the frequency distribution falls below a critical value. For asymmetrically correlated disorder, the model displays coherent traveling waves: the complex order parameter becomes nonzero and rotates with constant frequency different from the system's mean natural frequency. Thus, in both cases, correlated disorder can trigger phase coherence.

Optical Coherence Tomography Angiography of Retinal Cavernous Hemangioma.

Science.gov (United States)

Pierro, Luisa; Marchese, Alessandro; Gagliardi, Marco; Bandello, Francesco

2017-08-01

Retinal cavernous hemangioma is a rare, benign, retinal tumor characterized by angiomatous proliferation of vessels within the inner retina or the optic disc.1 Here we report a case of retinal cavernous hemangioma on the margin of the optic disc in the right eye of a 61-year-old asymptomatic female. The lesion was studied with multimodal imaging which included structural optical coherence tomography, fluorescein angiography, blue fundus auto-fluorescence, optical coherence tomography angiography (OCTA) (DRI OCT Triton; Topcon, Tokyo, Japan) and visual field examination. Blood circulation inside retinal cavernous hemangioma lesion is typically low-stagnant.2 However, OCTA demonstrated blood flow inside the lesion, illustrating its vascular circulation.3 Visual field was within the normal limits, except from a slight enlargement of the blind spot. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:684-685.]. Copyright 2017, SLACK Incorporated.

Optical laser systems at the Linac Coherent Light Source

Energy Technology Data Exchange (ETDEWEB)

Minitti, Michael P.; Robinson, Joseph S.; Coffee, Ryan N.; Edstrom, Steve; Gilevich, Sasha; Glownia, James M.; Granados, Eduardo; Hering, Philippe; Hoffmann, Matthias C.; Miahnahri, Alan; Milathianaki, Despina; Polzin, Wayne; Ratner, Daniel; Tavella, Franz; Vetter, Sharon; Welch, Marc; White, William E.; Fry, Alan R., E-mail: alanfry@slac.stanford.edu [Linac Coherent Light Source, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States)

2015-04-22

This manuscript serves as a reference to describe the optical laser sources and capabilities at the Linac Coherent Light Source. Ultrafast optical lasers play an essential role in exploiting the unique capabilities of recently commissioned X-ray free-electron laser facilities such as the Linac Coherent Light Source (LCLS). Pump–probe experimental techniques reveal ultrafast dynamics in atomic and molecular processes and reveal new insights in chemistry, biology, material science and high-energy-density physics. This manuscript describes the laser systems and experimental methods that enable cutting-edge optical laser/X-ray pump–probe experiments to be performed at LCLS.

Dynamic coherent backscattering mirror

Energy Technology Data Exchange (ETDEWEB)

Zeylikovich, I.; Xu, M., E-mail: mxu@fairfield.edu [Physics Department, Fairfield University, Fairfield, CT 06824 (United States)

2016-02-15

The phase of multiply scattered light has recently attracted considerable interest. Coherent backscattering is a striking phenomenon of multiple scattered light in which the coherence of light survives multiple scattering in a random medium and is observable in the direction space as an enhancement of the intensity of backscattered light within a cone around the retroreflection direction. Reciprocity also leads to enhancement of backscattering light in the spatial space. The random medium behaves as a reciprocity mirror which robustly converts a diverging incident beam into a converging backscattering one focusing at a conjugate spot in space. Here we first analyze theoretically this coherent backscattering mirror (CBM) phenomenon and then demonstrate the capability of CBM compensating and correcting both static and dynamic phase distortions occurring along the optical path. CBM may offer novel approaches for high speed dynamic phase corrections in optical systems and find applications in sensing and navigation.

Optical Coherence Tomography Technology and Quality Improvement Methods for Optical Coherence Tomography Images of Skin: A Short Review

OpenAIRE

Adabi, Saba; Turani, Zahra; Fatemizadeh, Emad; Clayton, Anne; Nasiriavanaki, Mohammadreza

2017-01-01

Optical coherence tomography (OCT) delivers 3-dimensional images of tissue microstructures. Although OCT imaging offers a promising high-resolution method, OCT images experience some artifacts that lead to misapprehension of tissue structures. Speckle, intensity decay, and blurring are 3 major artifacts in OCT images. Speckle is due to the low coherent light source used in the configuration of OCT. Intensity decay is a deterioration of light with respect to depth, and blurring is the conseque...

Full-field optical coherence tomography using immersion Mirau interference microscope.

Science.gov (United States)

Lu, Sheng-Hua; Chang, Chia-Jung; Kao, Ching-Fen

2013-06-20

In this study, an immersion Mirau interference microscope was developed for full-field optical coherence tomography (FFOCT). Both the reference and measuring arms of the Mirau interferometer were filled with water to prevent the problems associated with imaging a sample in air with conventional FFOCT systems. The almost-common path interferometer makes the tomographic system less sensitive to environmental disturbances. En face OCT images at various depths were obtained with phase-shifting interferometry and Hariharan algorithm. This immersion interferometric method improves depth and quality in three-dimensional OCT imaging of scattering tissue.

All-optically integrated photoacoustic and optical coherence tomography: A review

Directory of Open Access Journals (Sweden)

Wei Qiao

2017-07-01

Full Text Available All-optically integrated photoacoustic (PA and optical coherence tomography (OCT dual-mode imaging technology that could offer comprehensive pathological information for accurate diagnosis in clinic has gradually become a promising imaging technology in the aspect of biomedical imaging during the recent years. This review refers to the technology aspects of all-optical PA detection and system evolution of optically integrated PA and OCT, including Michelson interferometer dual-mode imaging system, Fabry–Perot (FP interferometer dual-mode imaging system and Mach–Zehnder interferometer dual-mode imaging system. It is believed that the optically integrated PA and OCT has great potential applications in biomedical imaging.

Acute Solar Retinopathy Imaged With Adaptive Optics, Optical Coherence Tomography Angiography, and En Face Optical Coherence Tomography.

Science.gov (United States)

Wu, Chris Y; Jansen, Michael E; Andrade, Jorge; Chui, Toco Y P; Do, Anna T; Rosen, Richard B; Deobhakta, Avnish

2018-01-01

Solar retinopathy is a rare form of retinal injury that occurs after direct sungazing. To enhance understanding of the structural changes that occur in solar retinopathy by obtaining high-resolution in vivo en face images. Case report of a young adult woman who presented to the New York Eye and Ear Infirmary with symptoms of acute solar retinopathy after viewing the solar eclipse on August 21, 2017. Results of comprehensive ophthalmic examination and images obtained by fundus photography, microperimetry, spectral-domain optical coherence tomography (OCT), adaptive optics scanning light ophthalmoscopy, OCT angiography, and en face OCT. The patient was examined after viewing the solar eclipse. Visual acuity was 20/20 OD and 20/25 OS. The patient was left-eye dominant. Spectral-domain OCT images were consistent with mild and severe acute solar retinopathy in the right and left eye, respectively. Microperimetry was normal in the right eye but showed paracentral decreased retinal sensitivity in the left eye with a central absolute scotoma. Adaptive optics images of the right eye showed a small region of nonwaveguiding photoreceptors, while images of the left eye showed a large area of abnormal and nonwaveguiding photoreceptors. Optical coherence tomography angiography images were normal in both eyes. En face OCT images of the right eye showed a small circular hyperreflective area, with central hyporeflectivity in the outer retina of the right eye. The left eye showed a hyperreflective lesion that intensified in area from inner to middle retina and became mostly hyporeflective in the outer retina. The shape of the lesion on adaptive optics and en face OCT images of the left eye corresponded to the shape of the scotoma drawn by the patient on Amsler grid. Acute solar retinopathy can present with foveal cone photoreceptor mosaic disturbances on adaptive optics scanning light ophthalmoscopy imaging. Corresponding reflectivity changes can be seen on en face OCT, especially

Integrated tunable quantum-dot laser for optical coherence tomography in the 1.7 μm wavelength region

NARCIS (Netherlands)

Tilma, B.W.; Jiao, Y.; Kotani, J.; Smalbrugge, B.; Ambrosius, H.P.M.M.; Thijs, P.J.A.; Leijtens, X.J.M.; Nötzel, R.; Smit, M.K.; Bente, E.A.J.M.

2012-01-01

In this paper we present the design and characterization of a monolithically integrated tunable laser for optical coherence tomography in medicine. This laser is the first monolithic photonic integrated circuit containing quantum-dot amplifiers, phase modulators and passive components. We

The analysis of time-resolved optically stimulated luminescence: I. Theoretical considerations

International Nuclear Information System (INIS)

Chithambo, M L

2007-01-01

This is the first of two linked papers on the analysis of time-resolved optically stimulated luminescence. This paper focusses on a theoretical basis of analytical methods and on methods for interpretation of time-resolved luminescence spectra and calculation of luminescence throughput. Using a comparative analysis of the principal features of time-resolved luminescence and relevant analogues from steady state optical stimulation, formulae for configuring a measurement system for optimum performance are presented. We also examine the possible use of stretched-exponential functions for analysis of time-resolved optically stimulated luminescence spectra

Detecting phase synchronization between coupled non-phase-coherent oscillators

International Nuclear Information System (INIS)

Follmann, Rosangela; Macau, Elbert E.N.; Rosa, Epaminondas

2009-01-01

We compare two methods for detecting phase synchronization in coupled non-phase-coherent oscillators. One method is based on the locking of self-sustained oscillators with an irregular signal. The other uses trajectory recurrences in phase space. We identify the pros and cons of both methods and propose guidelines to detect phase synchronization in data series.

All fiber optics circular-state swept source polarization-sensitive optical coherence tomography.

Science.gov (United States)

Lin, Hermann; Kao, Meng-Chun; Lai, Chih-Ming; Huang, Jyun-Cin; Kuo, Wen-Chuan

2014-02-01

A swept source (SS)-based circular-state (CS) polarization-sensitive optical coherence tomography (PS-OCT) constructed entirely with polarization-maintaining fiber optics components is proposed with the experimental verification. By means of the proposed calibration scheme, bulk quarter-wave plates can be replaced by fiber optics polarization controllers to, therefore, realize an all-fiber optics CS SSPS-OCT. We also present a numerical dispersion compensation method, which can not only enhance the axial resolution, but also improve the signal-to-noise ratio of the images. We demonstrate that this compact and portable CS SSPS-OCT system with an accuracy comparable to bulk optics systems requires less stringent lens alignment and can possibly serve as a technology to realize PS-OCT instrument for clinical applications (e.g., endoscopy). The largest deviations in the phase retardation (PR) and fast-axis (FA) angle due to sample probe in the linear scanning and a rotation angle smaller than 65 deg were of the same order as those in stationary probe setups. The influence of fiber bending on the measured PR and FA is also investigated. The largest deviations of the PR were 3.5 deg and the measured FA change by ~12 to 21 deg. Finally, in vivo imaging of the human fingertip and nail was successfully demonstrated with a linear scanning probe.

Noncontact measurement of elasticity for the detection of soft-tissue tumors using phase-sensitive optical coherence tomography combined with a focused air-puff system.

Science.gov (United States)

Wang, Shang; Li, Jiasong; Manapuram, Ravi Kiran; Menodiado, Floredes M; Ingram, Davis R; Twa, Michael D; Lazar, Alexander J; Lev, Dina C; Pollock, Raphael E; Larin, Kirill V

2012-12-15

We report on an optical noncontact method for the detection of soft-tissue tumors based on the measurement of their elasticity. A focused air-puff system is used to excite surface waves (SWs) on soft tissues with transient static pressure. A high-speed phase-sensitive optical coherence tomography system is used to measure the SWs as they propagate from the point of excitation. To evaluate the stiffness of soft tissues, the Young's modulus is quantified based on the group velocity of SWs. Pilot experiments were performed on ex vivo human myxoma and normal fat. Results demonstrate the feasibility of the proposed method to measure elasticity and differentiate soft-tissue tumors from normal tissues.

Optical pulse shaping approaches to coherent control

International Nuclear Information System (INIS)

Goswami, Debabrata

2003-01-01

The last part of the twentieth century has experienced a huge resurge of activity in the field of coherent light-matter interaction, more so in attempting to exert control over such interactions. Birth of coherent control was originally spurred by the theoretical understanding of the quantum interferences that lead to energy randomization and experimental developments in ultrafast laser spectroscopy. The theoretical predictions on control of reaction channels or energy randomization processes are still more dramatic than the experimental demonstrations, though this gap between the two is consistently reducing over the recent years with realistic theoretical models and technological developments. Experimental demonstrations of arbitrary optical pulse shaping have made some of the previously impracticable theoretical predictions possible to implement. Starting with the simple laser modulation schemes to provide proof-of-the-principle demonstrations, feedback loop pulse shaping systems have been developed that can actively manipulate some atomic and molecular processes. This tremendous experimental boost of optical pulse shaping developments has prospects and implications into many more new directions, such as quantum computing and terabit/sec data communications. This review captures certain aspects and impacts of optical pulse shaping into the fast developing areas of coherent control and other related fields. Currently available reviews focus on one or the other detailed aspects of coherent control, and the reader will be referred to such details as and when necessary for issues that are dealt in brief here. We will focus on the current issues including control of intramolecular dynamics and make connections to the future concepts, such as, quantum computation, biomedical applications, etc

Spectral domain optical coherence tomography findings in tamoxifen retinopathy--a case report.

Science.gov (United States)

Nair, Sandhya Narayanan; Anantharaman, Giridhar; Gopalakrishnan, Mahesh; Vyas, Jyothiprakash

2013-01-01

To report spectral domain optical coherence tomography findings in a case of typical tamoxifen retinopathy. In this observational case report, a patient with tamoxifen retinopathy was imaged with spectral domain optical coherence tomography and fundus auto fluorescence. Spectral domain optical coherence tomography showed numerous hyperreflective spots within the retina, mainly in the inner retinal layers in both the eyes. The external limiting membrane, the Inner Segment-Outer Segment junction, and the photoreceptors were not discernable at the fovea in the right eye. In the left eye, there was foveal atrophy with total loss of photoreceptors. The autofluorescent images showed macular hypofluorescence with foveal hyperfluorescence. Spectral domain optical coherence tomography demonstrated abnormalities in the outer retinal layers in tamoxifen retinopathy. There were also characteristic alterations in the autofluorescence pattern at the macula in tamoxifen retinopathy.

BER Analysis of Coherent Free-Space Optical Communication Systems with a Focal-Plane-Based Wavefront Sensor

Science.gov (United States)

Cao, Jingtai; Zhao, Xiaohui; Liu, Wei; Gu, Haijun

2018-03-01

A wavefront sensor is one of most important units for an adaptive optics system. Based on our previous works, in this paper, we discuss the bit-error-rate (BER) performance of coherent free space optical communication systems with a focal-plane-based wavefront sensor. Firstly, the theory of a focal-plane-based wavefront sensor is given. Then the relationship between the BER and the mixing efficiency with a homodyne receiver is discussed on the basis of binary-phase-shift-keying (BPSK) modulation. Finally, the numerical simulation results are shown that the BER will be decreased obviously after aberrations correction with the focal-plane-based wavefront sensor. In addition, the BER will decrease along with increasing number of photons received within a single bit. These analysis results will provide a reference for the design of the coherent Free space optical communication (FSOC) system.

Spatially-resolved in-situ quantification of biofouling using optical coherence tomography (OCT) and 3D image analysis in a spacer filled channel

KAUST Repository

Fortunato, Luca; Bucs, Szilard; Valladares Linares, Rodrigo; Cali, Corrado; Vrouwenvelder, Johannes S.; Leiknes, TorOve

2016-01-01

The use of optical coherence tomography (OCT) to investigate biomass in membrane systems has increased with time. OCT is able to characterize the biomass in-situ and non-destructively. In this study, a novel approach to process three-dimensional (3D

Optical coherent tomography in diagnoses of peripheral retinal degenarations

Directory of Open Access Journals (Sweden)

O. G. Pozdeyeva

2013-01-01

Full Text Available Purpose: Studying the capabilities of optical coherence tomography (RTVue-100, OPTOVUE, USA in evaluation of peripheral retinal degenerations, vitreoretinal adhesions, adjacent vitreous body as well as measurement of morphometric data.Methods: The study included 189 patients (239 eyes with peripheral retinal degeneration. 77 men and 112 women aged 18 to 84 underwent an ophthalmologic examination since November 2012 until October 2013. The peripheral retina was visualized with the help of optical coherence tomography («RTVue-100,» USA. The fundography was carried out using a Nikon NF505‑AF (Japan fundus camera. All patients were examined with a Goldmann lens.Results: Optical coherence tomography was used to evaluate different kinds of peripheral retinal degenerations, such as lattice and snail track degeneration, isolated retinal tears, cystoid retinal degeneration, pathological hyperpigmentation, retinoschisis and cobblestone degeneration. The following morphometric data were studied: dimensions of the lesion (average length, retinal thickness along the edge of the lesion, retinal thickness at the base of the lesion and the vitreoretinal interface.Conclusion: Optical coherence tomography is a promising in vivo visualization method which is useful in evaluation of peripheral retinal degenerations, vitreoretinal adhesions and tractions. It also provides a comprehensive protocolling system and monitoring. It will enable ophthalmologists to better define laser and surgical treatment indications and evaluate therapy effectiveness.

Optical coherent tomography in diagnoses of peripheral retinal degenarations

Directory of Open Access Journals (Sweden)

O. G. Pozdeyeva

2014-07-01

Full Text Available Purpose: Studying the capabilities of optical coherence tomography (RTVue-100, OPTOVUE, USA in evaluation of peripheral retinal degenerations, vitreoretinal adhesions, adjacent vitreous body as well as measurement of morphometric data.Methods: The study included 189 patients (239 eyes with peripheral retinal degeneration. 77 men and 112 women aged 18 to 84 underwent an ophthalmologic examination since November 2012 until October 2013. The peripheral retina was visualized with the help of optical coherence tomography («RTVue-100,» USA. The fundography was carried out using a Nikon NF505‑AF (Japan fundus camera. All patients were examined with a Goldmann lens.Results: Optical coherence tomography was used to evaluate different kinds of peripheral retinal degenerations, such as lattice and snail track degeneration, isolated retinal tears, cystoid retinal degeneration, pathological hyperpigmentation, retinoschisis and cobblestone degeneration. The following morphometric data were studied: dimensions of the lesion (average length, retinal thickness along the edge of the lesion, retinal thickness at the base of the lesion and the vitreoretinal interface.Conclusion: Optical coherence tomography is a promising in vivo visualization method which is useful in evaluation of peripheral retinal degenerations, vitreoretinal adhesions and tractions. It also provides a comprehensive protocolling system and monitoring. It will enable ophthalmologists to better define laser and surgical treatment indications and evaluate therapy effectiveness.

Simultaneous measurement of group refractive index and thickness of optical samples using optical coherence tomography

International Nuclear Information System (INIS)

Cheng, Hsu-Chih; Liu, Yi-Cheng

2010-01-01

Optical coherence tomography (OCT), based on a Michelson interferometer and utilizing low coherence light as the optical source, is a novel technique for the noninvasive imaging of optical scattering media. A simple OCT scheme based on a 3x3 fiber coupler is presented for the simultaneous measurement of the refractive index and thickness of optical samples. The proposed system enables the refractive index and thickness to be determined without any prior knowledge of the sample parameters and is characterized by a simple and compact configuration, a straightforward measurement procedure, and a low cost. The feasibility of the proposed approach is demonstrated experimentally using BK7 and B270 optical glass samples.

Coherent phonon optics in a chip with an electrically controlled active device.

Science.gov (United States)

Poyser, Caroline L; Akimov, Andrey V; Campion, Richard P; Kent, Anthony J

2015-02-05

Phonon optics concerns operations with high-frequency acoustic waves in solid media in a similar way to how traditional optics operates with the light beams (i.e. photons). Phonon optics experiments with coherent terahertz and sub-terahertz phonons promise a revolution in various technical applications related to high-frequency acoustics, imaging, and heat transport. Previously, phonon optics used passive methods for manipulations with propagating phonon beams that did not enable their external control. Here we fabricate a phononic chip, which includes a generator of coherent monochromatic phonons with frequency 378 GHz, a sensitive coherent phonon detector, and an active layer: a doped semiconductor superlattice, with electrical contacts, inserted into the phonon propagation path. In the experiments, we demonstrate the modulation of the coherent phonon flux by an external electrical bias applied to the active layer. Phonon optics using external control broadens the spectrum of prospective applications of phononics on the nanometer scale.

Digital adaptive optics for achieving space-invariant lateral resolution in optical coherence tomography

International Nuclear Information System (INIS)

Kumar, A.

2015-01-01

Optical coherence tomography (OCT) is a non-invasive optical interferometric imaging technique that provides reflectivity profiles of the sample structures with high axial resolution. The high axial resolution is due to the use of low coherence (broad-band) light source. However, the lateral resolution in OCT depends on the numerical aperture (NA) of the focusing/imaging optics and it is affected by defocus and other higher order optical aberrations induced by the imperfect optics, or by the sample itself.Hardware based adaptive optics (AO) has been successfully combined with OCT to achieve high lateral resolution in combination with high axial resolution provided by OCT. AO, which conventionally uses Shack-Hartmann wavefront sensor (SH WFS) and deformable mirror for wavefront sensing and correction respectively, can compensate for optical aberration and can enable diffraction-limited resolution in OCT. Visualization of cone photoreceptors in 3-D has been successfully demonstrated using AO-OCT. However, OCT being an interferometric imaging technique can provide access to phase information.This phase information can be exploited by digital adaptive optics (DAO) techniques to correct optical aberration in the post-processing step to obtain diffraction-limited space invariant lateral resolution throughout the image volume. Thus, the need for hardware based AO can be eliminated, which in turn can reduce the system complexity and economical cost. In the first paper of this thesis, a novel DAO method based on sub-aperture correlation is presented which is the digital equivalent of SH WFS. The advantage of this method is that it is non-iterative in nature and it does not require a priori knowledge of any system parameters such wavelength, focal length, NA or detector pixel size. For experimental proof, a FF SS OCT system was used and the sample consisted of resolution test target and a plastic plate that introduced random optical aberration. Experimental results show that

Determination of characteristics of degenerative joint disease using optical coherence tomography and polarization sensitive optical coherence tomography.

Science.gov (United States)

Xie, Tuqiang; Guo, Shuguang; Zhang, Jun; Chen, Zhongping; Peavy, George M

2006-10-01

Previous studies have demonstrated that optical coherence tomography (OCT) could be used to delineate alterations in the microstructure of cartilage, and have suggested that changes in the polarization state of light as detected by OCT could provide information on the birefringence properties of articular cartilage as influenced by disease. In this study we have used both OCT and polarization sensitive optical coherence tomography (PS-OCT) technologies to evaluate normal and abnormal bovine articular cartilage according to established structural, organizational, and birefringent characteristics of degenerative joint disease (DJD) in order to determine if this technology can be used to differentiate various stages of DJD as a minimally invasive imaging tool. Fresh bovine femoral-tibial joints were obtained from an abattoir, and 45 cartilage specimens were harvested from 8 tibial plateaus. Whole ex vivo specimens of normal and degenerative articular cartilage were imaged by both OCT and PS-OCT, then fixed and processed for histological evaluation. OCT/PS-OCT images and corresponding histology sections of each specimen were scored according to a modified Mankin structural grading scale and compared. OCT and PS-OCT imaging allowed structural evaluation of intact articular cartilage along a 6 mm surface length to a depth of 2 mm with a transverse resolution of 12 microm and an axial resolution of 10 microm. The OCT and PS-OCT images demonstrated characteristic alterations in the structure of articular cartilage with a high correlation to histological evaluation (kappa = 0.776). The OCT images were able to demonstrate early to advanced structural changes of articular cartilage while the optical phase retardation images obtained by PS-OCT imaging were able to discriminate areas where disorganization of the cartilage matrix was present, however, these characteristics are much different than those reported where OCT images alone were used to characterize tissue

Coherent beam combination using self-phase locked stimulated Brillouin scattering phase conjugate mirrors with a rotating wedge for high power laser generation.

Science.gov (United States)

Park, Sangwoo; Cha, Seongwoo; Oh, Jungsuk; Lee, Hwihyeong; Ahn, Heekyung; Churn, Kil Sung; Kong, Hong Jin

2016-04-18

The self-phase locking of a stimulated Brillouin scattering-phase conjugate mirror (SBS-PCM) allows a simple and scalable coherent beam combination of existing lasers. We propose a simple optical system composed of a rotating wedge and a concave mirror to overcome the power limit of the SBS-PCM. Its phase locking ability and the usefulness on the beam-combination laser are demonstrated experimentally. A four-beam combination is demonstrated using this SBS-PCM scheme. The relative phases between the beams were measured to be less than λ/24.7.

Face to phase: pitfalls in time delay estimation from coherency phase

NARCIS (Netherlands)

Campfens, S.F.; van der Kooij, Herman; Schouten, Alfred Christiaan

2014-01-01

Coherency phase is often interpreted as a time delay reflecting a transmission delay between spatially separated neural populations. However, time delays estimated from corticomuscular coherency are conflicting and often shorter than expected physiologically. Recent work suggests that

Field transients of coherent terahertz synchrotron radiation accessed via time-resolving and correlation techniques

Energy Technology Data Exchange (ETDEWEB)

Pohl, A.; Hübers, H.-W. [Humboldt-Universität zu Berlin, Institute of Physics, Newtonstraße 15, 12489 Berlin (Germany); Institute of Optical Sensor Systems, German Aerospace Center (DLR), Rutherfordstrasse 29, 12489 Berlin (Germany); Semenov, A. [Institute of Optical Sensor Systems, German Aerospace Center (DLR), Rutherfordstrasse 29, 12489 Berlin (Germany); Hoehl, A.; Ulm, G. [Physikalisch-Technische Bundesanstalt (PTB), Abbestraße 2-12, 10587 Berlin (Germany); Ries, M.; Wüstefeld, G. [Helmholz-Zentrum Berlin, Albert-Einstein-Str. 15, 12489 Berlin (Germany); Ilin, K.; Thoma, P.; Siegel, M. [Institute of Micro- and Nanoelectronic Systems, Karlsruhe Institute of Technology (KIT), Hertzstrasse 16, 76187 Karlsruhe (Germany)

2016-03-21

Decaying oscillations of the electric field in repetitive pulses of coherent synchrotron radiation in the terahertz frequency range was evaluated by means of time-resolving and correlation techniques. Comparative analysis of real-time voltage transients of the electrical response and interferograms, which were obtained with an ultrafast zero-bias Schottky diode detector and a Martin-Puplett interferometer, delivers close values of the pulse duration. Consistent results were obtained via the correlation technique with a pair of Golay Cell detectors and a pair of resonant polarisation-sensitive superconducting detectors integrated on one chip. The duration of terahertz synchrotron pulses does not closely correlate with the duration of single-cycle electric field expected for the varying size of electron bunches. We largely attribute the difference to the charge density oscillations in electron bunches and to the low-frequency spectral cut-off imposed by both the synchrotron beamline and the coupling optics of our detectors.

Towards spectral-domain optical coherence tomography on a silicon chip

NARCIS (Netherlands)

Akça, B.I.; Worhoff, Kerstin; Nguyen, V.D.; Kalkman, J.; van Leeuwen, Ton; de Ridder, R.M.; Pollnau, Markus

Optical coherence tomography (OCT) is a widely used optical imaging technology, particularly in the medical field, since it can provide non-invasive, sub-micrometer resolution diagnostic images of tissue. Current OCT systems contain optical fibers and free-space optical components which make these

Nondestructive analysis of automotive paints with spectral domain optical coherence tomography.

Science.gov (United States)

Dong, Yue; Lawman, Samuel; Zheng, Yalin; Williams, Dominic; Zhang, Jinke; Shen, Yao-Chun

2016-05-01

We have demonstrated for the first time, to our knowledge, the use of optical coherence tomography (OCT) as an analytical tool for nondestructively characterizing the individual paint layer thickness of multiple layered automotive paints. A graph-based segmentation method was used for automatic analysis of the thickness distribution for the top layers of solid color paints. The thicknesses measured with OCT were in good agreement with the optical microscope and ultrasonic techniques that are the current standard in the automobile industry. Because of its high axial resolution (5.5 μm), the OCT technique was shown to be able to resolve the thickness of individual paint layers down to 11 μm. With its high lateral resolution (12.4 μm), the OCT system was also able to measure the cross-sectional area of the aluminum flakes in a metallic automotive paint. The range of values measured was 300-1850  μm2. In summary, the proposed OCT is a noncontact, high-resolution technique that has the potential for inclusion as part of the quality assurance process in automobile coating.

Submicron Resolution Spectral-Domain Optical Coherence Tomography

KAUST Repository

Alarousu, Erkki; Jabbour, Ghassan

2013-01-01

Apparatuses and systems for submicron resolution spectral-domain optical coherence tomography (OCT) are disclosed. The system may use white light sources having wavelengths within 400-1000 nanometers, and achieve resolution below 1 .mu

Optical Coherence Tomography Angiography: Employing a Novel Technique for Investigation in Vogt-Koyanagi-Harada Disease

Directory of Open Access Journals (Sweden)

Panagiotis Giannakouras

2017-07-01

Full Text Available Purpose: To report a case of Vogt-Koyanagi-Harada (VKH disease and describe the imaging findings by means of optical coherence tomography angiography (OCTA. Methods: Medical and ophthalmological history, ophthalmological examination, laboratory evaluation, B-scan ultrasonography, fluorescein and indocyanine angiography, and optical coherence tomography (OCT were performed at baseline, as well as OCTA. Results: A 50-year-old healthy female presented with decreased vision in both eyes. A Topcon DRI OCT Triton Plus swept source OCT system was used to visualize and evaluate the retinal and choroidal vascular plexus. Patchy and confluent dark areas in the superficial and deep retinal capillary plexus and choriocapillaris corresponded to areas of hypoperfusion, analyzed as areas of ischemia. Conclusions and Importance: VKH disease is characterized by ocular, neurological, and integumentary findings in its complete form. We present a case of incomplete disease in a 50-year-old female evaluated by means of OCTA which is a novel technique that provides depth-resolved images of the retina and choroidal microvasculature without dye injection that allows better visualization and detailed evaluation of the retinal and choroidal vascular plexus.

Techniques for depth-resolved imaging through turbid media including coherence-gated imaging

International Nuclear Information System (INIS)

Dunsby, C; French, P M W

2003-01-01

This article aims to review the panoply of techniques for realising optical imaging through turbid media such as biological tissue. It begins by briefly discussing optical scattering and outlines the various approaches that have been developed to image through scattering media including spatial filtering, time-gated imaging and coherence-based techniques. The discussion includes scanning and wide-field techniques and concentrates on techniques to discriminate in favour of unscattered ballistic light although imaging with scattered light is briefly reviewed. Wide-field coherence-gated imaging techniques are discussed in some detail with particular emphasis placed on techniques to achieve real-time high-resolution three-dimensional imaging including through turbid media, providing rapid whole-field acquisition and high depth and transverse spatial resolution images. (topical review)

Dynamic Optical Coherence Tomography in Dermatology

DEFF Research Database (Denmark)

Ulrich, Martina; Themstrup, Lotte; De Carvalho, Nathalie

2016-01-01

Optical coherence tomography (OCT) represents a non-invasive imaging technology, which may be applied to the diagnosis of non-melanoma skin cancer and which has recently been shown to improve the diagnostic accuracy of basal cell carcinoma. Technical developments of OCT continue to expand the app...

High-speed asynchronous optical sampling for high-sensitivity detection of coherent phonons

International Nuclear Information System (INIS)

Dekorsy, T; Taubert, R; Hudert, F; Schrenk, G; Bartels, A; Cerna, R; Kotaidis, V; Plech, A; Koehler, K; Schmitz, J; Wagner, J

2007-01-01

A new optical pump-probe technique is implemented for the investigation of coherent acoustic phonon dynamics in the GHz to THz frequency range which is based on two asynchronously linked femtosecond lasers. Asynchronous optical sampling (ASOPS) provides the performance of on all-optical oscilloscope and allows us to record optically induced lattice dynamics over nanosecond times with femtosecond resolution at scan rates of 10 kHz without any moving part in the set-up. Within 1 minute of data acquisition time signal-to-noise ratios better than 10 7 are achieved. We present examples of the high-sensitivity detection of coherent phonons in superlattices and of the coherent acoustic vibration of metallic nanoparticles

Optical coherence tomography: Technique and applications

DEFF Research Database (Denmark)

Thomsen, Jakob Borup; Sander, Birgit; Mogensen, Mette

2009-01-01

Optical coherence tomography (OCT) is a noninvasive optical imaging modality providing real-time video rate images in two and three dimensions of biological tissues with micrometer resolution. OCT fills the gap between ultrasound and confocal microscopy, since it has a higher resolution than...... of retinal diseases. The potential of OCT in many other applications is currently being explored, such as in developmental biology, skin cancer diagnostics, vulnerable plaque detection in cardiology, esophageal diagnostics and a number of other applications within oncology....

A first demonstration of audio-frequency optical coherence elastography of tissue

Science.gov (United States)

Adie, Steven G.; Alexandrov, Sergey A.; Armstrong, Julian J.; Kennedy, Brendan F.; Sampson, David D.

2008-12-01

Optical elastography is aimed at using the visco-elastic properties of soft tissue as a contrast mechanism, and could be particularly suitable for high-resolution differentiation of tumour from surrounding normal tissue. We present a new approach to measure the effect of an applied stimulus in the kilohertz frequency range that is based on optical coherence tomography. We describe the approach and present the first in vivo optical coherence elastography measurements in human skin at audio excitation frequencies.

[Dome-shaped macula: appearance on ultrasound and optical coherence tomography].

Science.gov (United States)

Chéour, M; Ben Aleya, N; Brour, J; Falfoul, Y; Agrebi, S; Skhiri, M; Kraïem, A

2013-10-01

The purpose of our work is to demonstrate the role of optical coherence tomography and ocular ultrasound in the diagnosis of the dome-shaped macula in high myopia. We report the case of a patient with high myopia who presented with a decrease in visual acuity and metamorphopsia in the left eye. She underwent visual acuity measurement, biomicroscopic examination and measurement of axial length. B-mode ultrasound and optical coherence tomography showed a projection of the macula in the convexity of the myopic staphyloma confirming the diagnosis of dome-shaped macula. Dome-shaped macula is a recently discovered entity, which may be responsible for a decrease in visual acuity in patients with high myopic posterior staphyloma. Ultrasound and optical coherence tomography are very helpful in making the diagnosis. Copyright © 2013. Published by Elsevier Masson SAS.

Adaptive optics parallel spectral domain optical coherence tomography for imaging the living retina

Science.gov (United States)

Zhang, Yan; Rha, Jungtae; Jonnal, Ravi S.; Miller, Donald T.

2005-06-01

Although optical coherence tomography (OCT) can axially resolve and detect reflections from individual cells, there are no reports of imaging cells in the living human retina using OCT. To supplement the axial resolution and sensitivity of OCT with the necessary lateral resolution and speed, we developed a novel spectral domain OCT (SD-OCT) camera based on a free-space parallel illumination architecture and equipped with adaptive optics (AO). Conventional flood illumination, also with AO, was integrated into the camera and provided confirmation of the focus position in the retina with an accuracy of ±10.3 μm. Short bursts of narrow B-scans (100x560 μm) of the living retina were subsequently acquired at 500 Hz during dynamic compensation (up to 14 Hz) that successfully corrected the most significant ocular aberrations across a dilated 6 mm pupil. Camera sensitivity (up to 94 dB) was sufficient for observing reflections from essentially all neural layers of the retina. Signal-to-noise of the detected reflection from the photoreceptor layer was highly sensitive to the level of cular aberrations and defocus with changes of 11.4 and 13.1 dB (single pass) observed when the ocular aberrations (astigmatism, 3rd order and higher) were corrected and when the focus was shifted by 200 μm (0.54 diopters) in the retina, respectively. The 3D resolution of the B-scans (3.0x3.0x5.7 μm) is the highest reported to date in the living human eye and was sufficient to observe the interface between the inner and outer segments of individual photoreceptor cells, resolved in both lateral and axial dimensions. However, high contrast speckle, which is intrinsic to OCT, was present throughout the AO parallel SD-OCT B-scans and obstructed correlating retinal reflections to cell-sized retinal structures.

Silver nanoparticles (AgNPs) as a contrast agent for imaging of animal tissue using swept-source optical coherence tomography (SSOCT)

Science.gov (United States)

Mondal, Indranil; Raj, Shipra; Roy, Poulomi; Poddar, Raju

2018-01-01

We present noninvasive three-dimensional depth-resolved imaging of animal tissue with a swept-source optical coherence tomography system at 1064 nm center wavelength and silver nanoparticles (AgNPs) as a potential contrast agent. A swept-source laser light source is used to enable an imaging rate of 100 kHz (100 000 A-scans s-1). Swept-source optical coherence tomography is a new variant of the optical coherence tomography (OCT) technique, offering unique advantages in terms of sensitivity, reduction of motion artifacts, etc. To enhance the contrast of an OCT image, AgNPs are utilized as an exogeneous contrast agent. AgNPs are synthesized using a modified Tollens method and characterization is done by UV-vis spectroscopy, dynamic light scattering, scanning electron microscopy and energy dispersive x-ray spectroscopy. In vitro imaging of chicken breast tissue, with and without the application of AgNPs, is performed. The effect of AgNPs is studied with different exposure times. A mathematical model is also built to calculate changes in the local scattering coefficient of tissue from OCT images. A quantitative estimation of scattering coefficient and contrast is performed for tissues with and without application of AgNPs. Significant improvement in contrast and increase in scattering coefficient with time is observed.

Fiber optic coherent laser radar 3d vision system

International Nuclear Information System (INIS)

Sebastian, R.L.; Clark, R.B.; Simonson, D.L.

1994-01-01

Recent advances in fiber optic component technology and digital processing components have enabled the development of a new 3D vision system based upon a fiber optic FMCW coherent laser radar. The approach includes a compact scanner with no moving parts capable of randomly addressing all pixels. The system maintains the immunity to lighting and surface shading conditions which is characteristic of coherent laser radar. The random pixel addressability allows concentration of scanning and processing on the active areas of a scene, as is done by the human eye-brain system

High speed all optical shear wave imaging optical coherence elastography (Conference Presentation)

Science.gov (United States)

Song, Shaozhen; Hsieh, Bao-Yu; Wei, Wei; Shen, Tueng; O'Donnell, Matthew; Wang, Ruikang K.

2016-03-01

Optical Coherence Elastography (OCE) is a non-invasive testing modality that maps the mechanical property of soft tissues with high sensitivity and spatial resolution using phase-sensitive optical coherence tomography (PhS-OCT). Shear wave OCE (SW-OCE) is a leading technique that relies on the speed of propagating shear waves to provide a quantitative elastography. Previous shear wave imaging OCT techniques are based on repeated M-B scans, which have several drawbacks such as long acquisition time and repeated wave stimulations. Recent developments of Fourier domain mode-locked high-speed swept-source OCT system has enabled enough speed to perform KHz B-scan rate OCT imaging. Here we propose ultra-high speed, single shot shear wave imaging to capture single-shot transient shear wave propagation to perform SW-OCE. The frame rate of shear wave imaging is 16 kHz, at A-line rate of ~1.62 MHz, which allows the detection of high-frequency shear wave of up to 8 kHz. The shear wave is generated photothermal-acoustically, by ultra-violet pulsed laser, which requires no contact to OCE subjects, while launching high frequency shear waves that carries rich localized elasticity information. The image acquisition and processing can be performed at video-rate, which enables real-time 3D elastography. SW-OCE measurements are demonstrated on tissue-mimicking phantoms and porcine ocular tissue. This approach opens up the feasibility to perform real-time 3D SW-OCE in clinical applications, to obtain high-resolution localized quantitative measurement of tissue biomechanical property.

Blunt ocular trauma at the posterior pole in optical coherence tomography and fluorescein angiography

International Nuclear Information System (INIS)

Meyer, C.H.; Eter, N.; Mennel, S.; Kroll, P.

2007-01-01

Blunt ocular trauma at the posterior pole may involve a variety of retinal structures. We examined the most frequent retinal trauma (choroidal folds, commotion retinae, choroidal rupture, valsalva retinopathy, PPE-tears, Purtscher's Retinopathy etc.) by optical coherence tomography (OCT). The damaged pre-, intra- or subretinal structures were clearly visible. The OCT is during acute and chronic phases of different traumatic events an important diagnostic tool. (author) [de

Quantum teleportation of an arbitrary two-mode coherent state using only linear optics elements

International Nuclear Information System (INIS)

Ho Ngoc Phien; Nguyen Ba An

2008-01-01

We propose a linear optics scheme to teleport an arbitrary two-mode coherent state. The devices used are beam-splitters, phase-shifters and ideal photo-detectors capable of distinguishing between even and odd photon numbers. The scheme achieves faithful teleportation with a probability of 1/4. However, with additional use of an appropriate displacement operator, the teleported state can always be made near-faithful

Single myelin fiber imaging in living rodents without labeling by deep optical coherence microscopy

Science.gov (United States)

Ben Arous, Juliette; Binding, Jonas; Léger, Jean-François; Casado, Mariano; Topilko, Piotr; Gigan, Sylvain; Claude Boccara, A.; Bourdieu, Laurent

2011-11-01

Myelin sheath disruption is responsible for multiple neuropathies in the central and peripheral nervous system. Myelin imaging has thus become an important diagnosis tool. However, in vivo imaging has been limited to either low-resolution techniques unable to resolve individual fibers or to low-penetration imaging of single fibers, which cannot provide quantitative information about large volumes of tissue, as required for diagnostic purposes. Here, we perform myelin imaging without labeling and at micron-scale resolution with >300-μm penetration depth on living rodents. This was achieved with a prototype [termed deep optical coherence microscopy (deep-OCM)] of a high-numerical aperture infrared full-field optical coherence microscope, which includes aberration correction for the compensation of refractive index mismatch and high-frame-rate interferometric measurements. We were able to measure the density of individual myelinated fibers in the rat cortex over a large volume of gray matter. In the peripheral nervous system, deep-OCM allows, after minor surgery, in situ imaging of single myelinated fibers over a large fraction of the sciatic nerve. This allows quantitative comparison of normal and Krox20 mutant mice, in which myelination in the peripheral nervous system is impaired. This opens promising perspectives for myelin chronic imaging in demyelinating diseases and for minimally invasive medical diagnosis.

Single myelin fiber imaging in living rodents without labeling by deep optical coherence microscopy.

Science.gov (United States)

Ben Arous, Juliette; Binding, Jonas; Léger, Jean-François; Casado, Mariano; Topilko, Piotr; Gigan, Sylvain; Boccara, A Claude; Bourdieu, Laurent

2011-11-01

Myelin sheath disruption is responsible for multiple neuropathies in the central and peripheral nervous system. Myelin imaging has thus become an important diagnosis tool. However, in vivo imaging has been limited to either low-resolution techniques unable to resolve individual fibers or to low-penetration imaging of single fibers, which cannot provide quantitative information about large volumes of tissue, as required for diagnostic purposes. Here, we perform myelin imaging without labeling and at micron-scale resolution with >300-μm penetration depth on living rodents. This was achieved with a prototype [termed deep optical coherence microscopy (deep-OCM)] of a high-numerical aperture infrared full-field optical coherence microscope, which includes aberration correction for the compensation of refractive index mismatch and high-frame-rate interferometric measurements. We were able to measure the density of individual myelinated fibers in the rat cortex over a large volume of gray matter. In the peripheral nervous system, deep-OCM allows, after minor surgery, in situ imaging of single myelinated fibers over a large fraction of the sciatic nerve. This allows quantitative comparison of normal and Krox20 mutant mice, in which myelination in the peripheral nervous system is impaired. This opens promising perspectives for myelin chronic imaging in demyelinating diseases and for minimally invasive medical diagnosis.

Optical Coherent Receiver Enables THz Wireless Bridge

DEFF Research Database (Denmark)

Yu, Xianbin; Liu, Kexin; Zhang, Hangkai

2016-01-01

We experimentally demonstrated a 45 Gbit/s 400 GHz photonic wireless communication system enabled by an optical coherent receiver, which has a high potential in fast recovery of high data rate connections, for example, in disaster....

Optical coherent control in semiconductors

DEFF Research Database (Denmark)

Østergaard, John Erland; Vadim, Lyssenko; Hvam, Jørn Märcher

2001-01-01

of quantum control including the recent applications to semiconductors and nanostructures. We study the influence of inhomogeneous broadening in semiconductors on CC results. Photoluminescence (PL) and the coherent emission in four-wave mixing (FWM) is recorded after resonant excitation with phase...

DS-OCDMA Encoder/Decoder Performance Analysis Using Optical Low-Coherence Reflectometry

Science.gov (United States)

Fsaifes, Ihsan; Lepers, Catherine; Obaton, Anne-Francoise; Gallion, Philippe

2006-08-01

Direct-sequence optical code-division multiple-access (DS-OCDMA) encoder/decoder based on sampled fiber Bragg gratings (S-FBGs) is characterized using phase-sensitive optical low-coherence reflectometry (OLCR). The OLCR technique allows localized measurements of FBG wavelength and physical length inside one S-FBG. This paper shows how the discrepancies between specifications and measurements of the different FBGs have some impact on spectral and temporal pulse responses of the OCDMA encoder/decoder. The FBG physical lengths lower than the specified ones are shown to affect the mean optical power reflected by the OCDMA encoder/decoder. The FBG wavelengths that are detuned from each other induce some modulations of S-FBG reflectivity resulting in encoder/decoder sensitivity to laser wavelength drift of the OCDMA system. Finally, highlighted by this OLCR study, some solutions to overcome limitations in performance with the S-FBG technology are suggested.

Noise study of all-normal dispersion supercontinuum sources for potential application in optical coherence tomography

DEFF Research Database (Denmark)

Bravo Gonzalo, Ivan; Engelsholm, Rasmus Dybbro; Bang, Ole

2017-01-01

bandwidths, such sources are characterized by large intensity fluctuations, limiting their performance for applications in imaging such as optical coherence tomography (OCT). An approach to eliminate the influence of noise sensitive effects is to use a so-called all-normal dispersion (ANDi) fiber, in which...... the dispersion is normal for all the wavelengths of interest. Pumping these types of fibers with short enough femtosecond pulses allows to suppress stimulated Raman scattering (SRS), which is known to be as noisy process as modulation instability (MI), and coherent SC is generated through self-phase modulation...... (SPM) and optical wave breaking (OWB). In this study, we show the importance of the pump laser and fiber parameters in the design of low-noise ANDi based SC sources, for application in OCT. We numerically investigate the pulse-to-pulse fluctuations of the SC, calculating the relative intensity noise...

Comparison of optic area measurement using fundus photography and optical coherence tomography between optic nerve head drusen and control subjects.

Science.gov (United States)

Flores-Rodríguez, Patricia; Gili, Pablo; Martín-Ríos, María Dolores; Grifol-Clar, Eulalia

2013-03-01

To compare optic disc area measurement between optic nerve head drusen (ONHD) and control subjects using fundus photography, time-domain optical coherence tomography (TD-OCT) and spectral-domain optical coherence tomography (SD-OCT). We also made a comparison between each of the three techniques. We performed our study on 66 eyes (66 patients) with ONHD and 70 healthy control subjects (70 controls) with colour ocular fundus photography at 20º (Zeiss FF 450 IR plus), TD-OCT (Stratus OCT) with the Fast Optic Disc protocol and SD-OCT (Cirrus OCT) with the Optic Disc Cube 200 × 200 protocol for measurement of the optic disc area. The measurements were made by two observers and in each measurement a correction of the image magnification factor was performed. Measurement comparison using the Student's t-test/Mann-Whitney U test, the intraclass correlation coefficient, Pearson/Spearman rank correlation coefficient and the Bland-Altman plot was performed in the statistical analysis. Mean and standard deviation (SD) of the optic disc area in ONHD and in controls was 2.38 (0.54) mm(2) and 2.54 (0.42) mm(2), respectively with fundus photography; 2.01 (0.56) mm(2) and 1.66 (0.37) mm(2), respectively with TD-OCT, and 2.03 (0.49) mm(2) and 1.75 (0.38) mm(2), respectively with SD-OCT. In ONHD and controls, repeatability of optic disc area measurement was excellent with fundus photography and optical coherence tomography (TD-OCT and SD-OCT), but with a low degree of agreement between both techniques. Optic disc area measurement is smaller in ONHD compared to healthy subjects with fundus photography, unlike time-domain and spectral-domain optical coherence tomography in which the reverse is true. Both techniques offer good repeatability, but a low degree of correlation and agreement, which means that optic disc area measurement is not interchangeable or comparable between techniques. Ophthalmic & Physiological Optics © 2013 The College of Optometrists.

All-optical microwave signal processing based on optical phase modulation

Science.gov (United States)

Zeng, Fei

This thesis presents a theoretical and experimental study of optical phase modulation and its applications in all-optical microwave signal processing, which include all-optical microwave filtering, all-optical microwave mixing, optical code-division multiple-access (CDMA) coding, and ultrawideband (UWB) signal generation. All-optical microwave signal processing can be considered as the use of opto-electronic devices and systems to process microwave signals in the optical domain, which provides several significant advantages such as low loss, low dispersion, light weight, high time bandwidth products, and immunity to electromagnetic interference. In conventional approaches, the intensity of an optical carrier is modulated by a microwave signal based on direct modulation or external modulation. The intensity-modulated optical signal is then fed to a photonic circuit or system to achieve specific signal processing functionalities. The microwave signal being processed is usually obtained based on direct detection, i.e., an opto-electronic conversion by use of a photodiode. In this thesis, the research efforts are focused on the optical phase modulation and its applications in all-optical microwave signal processing. To avoid using coherent detection which is complicated and costly, simple and effective phase modulation to intensity modulation (PM-IM) conversion schemes are pursued. Based on a theoretical study of optical phase modulation, two approaches to achieving PM-IM conversions are proposed. In the first approach, the use of chromatic dispersion induced by a dispersive device to alter the phase relationships among the sidebands and the optical carrier of a phase-modulated optical signal to realize PM-IM conversion is investigated. In the second approach, instead of using a dispersive device, the PM-IM conversion is realized based on optical frequency discrimination implemented using an optical filter. We show that the proposed PM-IM conversion schemes can be

Fundus autofluorescence and optical coherence tomography findings in thiamine responsive megaloblastic anemia.

Science.gov (United States)

Ach, Thomas; Kardorff, Rüdiger; Rohrschneider, Klaus

2015-01-01

To report ophthalmologic fundus autofluorescence and spectral domain optical coherence tomography findings in a patient with thiamine responsive megaloblastic anemia (TRMA). A 13-year-old girl with genetically proven TRMA was ophthalmologically (visual acuity, funduscopy, perimetry, electroretinogram) followed up over >5 years. Fundus imaging also included autofluorescence and spectral domain optical coherence tomography. During a 5-year follow-up, visual acuity and visual field decreased, despite a special TRMA diet. Funduscopy revealed bull's eye appearance, whereas fundus autofluorescence showed central and peripheral hyperfluorescence and perifoveal hypofluorescence. Spectral domain optical coherence tomography revealed affected inner segment ellipsoid band and irregularities in the retinal pigment epithelium and choroidea. Autofluorescence and spectral domain optical coherence tomography findings in a patient with TRMA show retinitis pigmentosa-like retina, retinal pigment epithelium, and choroid alterations. These findings might progress even under special TRMA diet, indispensable to life. Ophthalmologist should consider TRMA in patients with deafness and ophthalmologic disorders.

Remote Raman microimaging using an AOTF and a spatially coherent microfiber optical probe

International Nuclear Information System (INIS)

Trey Skinner, H.; Cooney, T.F.; Sharma, S.K.; Angel, S.M.

1996-01-01

A fiber-optic Raman microimaging probe is described that is suitable for acquiring high-spatial-resolution Raman images in sampling situations with no clear line of sight. A high-power near-infrared diode laser combined with an acousto-optic tunable filter and a spatially coherent optical fiber bundle allow fluorescence-free Raman images of remotely located samples to be acquired at distances up to several meters. The feasibility of this technique is demonstrated with Raman images of (1) a pellet containing a mixture of a highly scattering sample, bis-methylstyrylbenzene (BMSB), KCl, and graphite, and (2) a partially graphitized diamond. These images clearly show phase boundaries over an area of approximately 0.1 mm 2 with ∼4-μm resolution. copyright 1996 Society for Applied Spectroscopy

Coherent Microwave-to-Optical Conversion via Six-Wave Mixing in Rydberg Atoms

Science.gov (United States)

Han, Jingshan; Vogt, Thibault; Gross, Christian; Jaksch, Dieter; Kiffner, Martin; Li, Wenhui

2018-03-01

We present an experimental demonstration of converting a microwave field to an optical field via frequency mixing in a cloud of cold 87Rb atoms, where the microwave field strongly couples to an electric dipole transition between Rydberg states. We show that the conversion allows the phase information of the microwave field to be coherently transferred to the optical field. With the current energy level scheme and experimental geometry, we achieve a photon-conversion efficiency of ˜0.3 % at low microwave intensities and a broad conversion bandwidth of more than 4 MHz. Theoretical simulations agree well with the experimental data, and they indicate that near-unit efficiency is possible in future experiments.

Quantum state engineering, purification, and number-resolved photon detection with high-finesse optical cavities

DEFF Research Database (Denmark)

Nielsen, Anne E. B.; Muschik, Christine A.; Giedke, Geza

2010-01-01

We propose and analyze a multifunctional setup consisting of high-finesse optical cavities, beam splitters, and phase shifters. The basic scheme projects arbitrary photonic two-mode input states onto the subspace spanned by the product of Fock states |n>|n> with n=0,1,2,.... This protocol does no...... is especially attractive as a generalization to many modes allows for distribution and purification of entanglement in networks. In an alternative working mode, the setup allows for quantum nondemolition number resolved photodetection in the optical domain....

Nonlinear intermodulation distortion suppression in coherent analog fiber optic link using electro-optic polymeric dual parallel Mach-Zehnder modulator.

Science.gov (United States)

Kim, Seong-Ku; Liu, Wei; Pei, Qibing; Dalton, Larry R; Fetterman, Harold R

2011-04-11

A linearized dual parallel Mach-Zehnder modulator (DPMZM) based on electro-optic (EO) polymer was both fabricated, and experimentally used to suppress the third-order intermodulation distortion (IMD3) in a coherent analog fiber optic link. This optical transmitter design was based on a new EO chromophore called B10, which was synthesized for applications dealing with the fiber-optic communication systems. The chromophore was mixed with amorphous polycarbonate (APC) to form the waveguide's core material. The DPMZM was configured with two MZMs, of different lengths in parallel, with unbalanced input and output couplers and a phase shifter in one arm. In this configuration each of the MZMs carried a different optical power, and imposed a different depth of optical modulation. When the two optical beams from the MZMs were combined to generate the transmitted signal it was possible to set the IMD3 produced by each modulator to be equal in amplitude but 180° out of phase from the other. Therefore, the resulting IMD3 of the DPMZM transmitter was effectively canceled out during two-tone experiments. A reduction of the IMD3 below the noise floor was observed while leaving fifth-order distortion (IMD5) as the dominant IMD product. This configuration has the capability of broadband operation and shot-noise limited operation simultaneously. © 2011 Optical Society of America

Robust intravascular optical coherence elastography by line correlations

International Nuclear Information System (INIS)

Soest, Gijs van; Mastik, Frits; Jong, Nico de; Steen, Anton F W van der

2007-01-01

We present a new method for intravascular optical coherence elastography, which is robust against motion artefacts. It employs the correlation between adjacent lines, instead of subsequent frames. Pressure to deform the tissue is applied synchronously with the line scan rate of the optical coherence tomography (OCT) instrument. The viability of the method is demonstrated with a simulation study. We find that the root mean square (rms) error of the displacement estimate is 0.55 μm, and the rms error of the strain is 0.6%. It is shown that high-strain spots in the vessel wall, such as observed at the sites of vulnerable atherosclerotic lesions, can be detected with the technique

Physical-layer network coding in coherent optical OFDM systems.

Science.gov (United States)

Guan, Xun; Chan, Chun-Kit

2015-04-20

We present the first experimental demonstration and characterization of the application of optical physical-layer network coding in coherent optical OFDM systems. It combines two optical OFDM frames to share the same link so as to enhance system throughput, while individual OFDM frames can be recovered with digital signal processing at the destined node.

Unconditional quantum cloning of coherent states with linear optics

International Nuclear Information System (INIS)

Leuchs, G.; Andersen, U.L.; Josse, V.

2005-01-01

Intense light pulses with non-classical properties are used to implement protocols for quantum communication. Most of the elements in the tool box needed to assemble the experimental set-ups for these protocols are readily described by Bogoliubov transformations corresponding to Gaussian transformations that map Gaussian states onto Gaussian states. One particularly interesting application is quantum cloning of a coherent state. A scheme for optimal Gaussian cloning of optical coherent states is proposed and experimentally demonstrated. Its optical realization is based entirely on simple linear optical elements and homodyne detection. The optimality of the presented scheme is only limited by detection inefficiencies. Experimentally we achieved a cloning fidelity of about 65%, which almost touches the optimal value of 2/3. (author)

Coherent time-stretch transformation for real-time capture of wideband signals.

Science.gov (United States)

Buckley, Brandon W; Madni, Asad M; Jalali, Bahram

2013-09-09

Time stretch transformation of wideband waveforms boosts the performance of analog-to-digital converters and digital signal processors by slowing down analog electrical signals before digitization. The transform is based on dispersive Fourier transformation implemented in the optical domain. A coherent receiver would be ideal for capturing the time-stretched optical signal. Coherent receivers offer improved sensitivity, allow for digital cancellation of dispersion-induced impairments and optical nonlinearities, and enable decoding of phase-modulated optical data formats. Because time-stretch uses a chirped broadband (>1 THz) optical carrier, a new coherent detection technique is required. In this paper, we introduce and demonstrate coherent time stretch transformation; a technique that combines dispersive Fourier transform with optically broadband coherent detection.

Spectral phase encoding of ultra-short optical pulse in time domain for OCDMA application.

Science.gov (United States)

Wang, Xu; Wada, Naoya

2007-06-11

We propose a novel reconfigurable time domain spectral phase encoding (SPE) scheme for coherent optical code-division-multiple-access application. In the proposed scheme, the ultra-short optical pulse is stretched by dispersive device and the SPE is done in time domain using high speed phase modulator. The time domain SPE scheme is robust to wavelength drift of the light source and is very flexible and compatible with the fiber optical system. Proof-of-principle experiments of encoding with 16-chip, 20 GHz/chip binary-phase-shift-keying codes and 1.25 Gbps data transmission have been successfully demonstrated together with an arrayed-wave-guide decoder.

Quantum-coherent coupling of a mechanical oscillator to an optical cavity mode.

Science.gov (United States)

Verhagen, E; Deléglise, S; Weis, S; Schliesser, A; Kippenberg, T J

2012-02-01

Optical laser fields have been widely used to achieve quantum control over the motional and internal degrees of freedom of atoms and ions, molecules and atomic gases. A route to controlling the quantum states of macroscopic mechanical oscillators in a similar fashion is to exploit the parametric coupling between optical and mechanical degrees of freedom through radiation pressure in suitably engineered optical cavities. If the optomechanical coupling is 'quantum coherent'--that is, if the coherent coupling rate exceeds both the optical and the mechanical decoherence rate--quantum states are transferred from the optical field to the mechanical oscillator and vice versa. This transfer allows control of the mechanical oscillator state using the wide range of available quantum optical techniques. So far, however, quantum-coherent coupling of micromechanical oscillators has only been achieved using microwave fields at millikelvin temperatures. Optical experiments have not attained this regime owing to the large mechanical decoherence rates and the difficulty of overcoming optical dissipation. Here we achieve quantum-coherent coupling between optical photons and a micromechanical oscillator. Simultaneously, coupling to the cold photon bath cools the mechanical oscillator to an average occupancy of 1.7 ± 0.1 motional quanta. Excitation with weak classical light pulses reveals the exchange of energy between the optical light field and the micromechanical oscillator in the time domain at the level of less than one quantum on average. This optomechanical system establishes an efficient quantum interface between mechanical oscillators and optical photons, which can provide decoherence-free transport of quantum states through optical fibres. Our results offer a route towards the use of mechanical oscillators as quantum transducers or in microwave-to-optical quantum links.

Fundus autofluorescence and optical coherence tomography of congenital grouped albinotic spots.

Science.gov (United States)

Kim, David Y; Hwang, John C; Moore, Anthony T; Bird, Alan C; Tsang, Stephen H

2010-09-01

The purpose of this study was to describe the findings of fundus autofluores-cence (FAF) and optical coherence tomography in a series of patients with congenital grouped albinotic spots. Three eyes of three patients with congenital grouped albinotic spots were evaluated with FAF and optical coherence tomography imaging to evaluate the nature of the albinotic spots. In all three eyes with congenital grouped albinotic spots, FAF imaging showed autofluorescent spots corresponding to the albinotic spots seen on stereo biomicroscopy. One eye also had additional spots detected on FAF imaging that were not visible on stereo biomicroscopy or color fundus photographs. Fundus autofluorescence imaging of the spots showed decreased general autofluorescence and decreased peripheral autofluorescence surrounding central areas of retained or increased autofluorescence. Optical coherence tomography showed a disruption in signal from the hyperreflective layer corresponding to the inner and outer segment junction and increased signal backscattering from the choroid in the area of the spots. Fluorescein angiography showed early and stable hyperfluorescence of the spots without leakage. In this case series, FAF showed decreased autofluorescence of the spots consistent with focal retinal pigment epithelium atrophy or abnormal material blocking normal autofluorescence and areas of increased autofluorescence suggesting retinal pigment epithelium dysfunction. The findings of optical coherence tomography and fluorescein angiography suggest photoreceptor and retinal pigment epithelium layer abnormalities. Fundus autofluorescence and optical coherence tomography are useful noninvasive diagnostic adjuncts that can aid in the diagnosis of congenital grouped albinotic spots, help determine extent of disease, and contribute to our understanding of its pathophysiology.

Morpho-functional evaluation of torpedo maculopathy with optical coherence tomography angiography and microperimetry

Directory of Open Access Journals (Sweden)

Gabriela Grimaldi

2018-06-01

Full Text Available Purpose: To report the case of a 13-year-old girl with torpedo maculopathy, evaluated with multimodal morpho-functional retinal imaging, including fundus photography, infra-red and blue fundus autofluorescence, swept-source optical coherence tomography (OCT, en face OCT, OCT angiography and microperimetry (MP. Observations: On fundus examination, a torpedo-like hypopigmented lesion was observed temporal to the fovea in the left eye. OCT showed disruption of outer retinal layers and the presence of a subretinal cleft. On OCTA, a diffuse attenuation of signal from choriocapillaris was observed along the lesion. Functional analysis with MP revealed a reduction of retinal sensitivity over the lesion. Conclusions: and importance: On OCTA, torpedo maculopathy is characterized by vascular alterations of the choriocapillaris along the lesion. Keywords: Optical coherence tomography angiography, Torpedo maculopathy, Microperimetry, Swept-source optical coherence tomography, En face optical coherence tomography

Optical coherence tomography findings and retinal changes after vitrectomy for optic disc pit maculopathy

Directory of Open Access Journals (Sweden)

Gaurav Sanghi

2014-01-01

Full Text Available Purpose : To study the optical coherence tomography (OCT patterns in optic disc pit maculopathy and retinal changes after vitreous surgery. Materials and Methods : Retrospective review of consecutive cases with optic disc pit maculopathy seen at two tertiary eye institutes from January 2005 to June 2009. Results : Twenty-four eyes of 23 patients are included. The presenting visual acuity ranged from 20/400 to 20/20 (median:20/80. The median age at presentation was 24 years (range, 6-57 years. Optical coherence tomography demonstrated a combination of retinoschisis and outer layer detachment (OLD in 19 (79.17% eyes, OLD only in 3 (12.5% eyes and retinoschisis only in 2 (8.33% eyes. An obvious communication (outer layer hole between the schisis and OLD was seen in 14 (73.68% of the 19 eyes with both features. Of the 21 eyes with retinoschisis, schisis was present in multiple layers in 15 (71.43% and single layer in 6 (28.57% eyes. Eleven eyes underwent pars plana vitrectomy including creation of posterior vitreous detachment (PVD, fluid-air exchange, low intensity laser photocoagulation at the temporal edge of the optic disc pit and non-expansile perfluoropropane gas (14% injection. Five (45.45% of 11 eyes undergoing vitrectomy had complete resolution and 4 (36.36% eyes had partial resolution of maculopathy. Visual acuity improved in 8 (72.72% of 11 eyes. Conclusion : Optical coherence tomography demonstrates multiple layer schisis and outer layer detachment as main features of optic disc pit maculopathy. Vitrectomy with PVD induction, laser photocoagulation and gas tamponade results in anatomical and visual improvement in most cases with optic disc pit maculopathy.

A coherent free space optical link for long distance clock comparison, navigation, and communication: The Mini-Doll project

Science.gov (United States)

Djerroud, K.; Samain, E.; Clairon, A.; Acef, O.; Man, N.; Lemonde, P.; Wolf, P.

2017-11-01

We describe the realization of a 5 km free space coherent optical link through the turbulent atmosphere between a telescope and a ground target. We present the phase noise of the link, limited mainly by atmospheric turbulence and mechanical vibrations of the telescope and the target. We discuss the implications of our results for applications, with particular emphasis on optical Doppler ranging to satellites and long distance frequency transfer.

Dental diagnostics using optical coherence techniques

Energy Technology Data Exchange (ETDEWEB)

Nathel, H. [Lawrence Livermore National Lab., CA (United States); Colston, B. [Univ. of California, San Francisco, CA (United States); Armitage, G. [Univ. of California, Davis, CA (United States)] [and others

1994-11-15

Optical radiation can be used for diagnostic purposes in oral medicine. However, due to the turbid, amorphous, and inhomogeneous nature of dental tissue conventional techniques used to transilluminate materials are not well suited to dental tissues. Optical coherence techniques either in the time- of frequency-domain offer the capabilities of discriminating scattered from unscattered light, thus allowing for imaging through turbid tissue. Currently, using optical time-domain reflectometry we are able to discriminate specular from diffuse reflections occurring at tissue boundaries. We have determined the specular reflectivity of enamel and dentin to be approximately 6.6 x 10{sup -5} and 1.3 x 10{sup -6}, respectively. Implications to periodontal imaging will be discussed.

Mesoscopic non-coherence as phase diffusion

International Nuclear Information System (INIS)

Milman, Perola; Davidovich, Luiz; Castin, Yvan

1997-01-01

In this work, we approach to the question whether it is possible to describe the process of non-coherence in terms of phase diffusion ψ. We will show that this can be done, for an electromagnetic field mode in a cavity interacting with a continuum of modes outside the cavity, for any value of α, where |α> is an eigenstate of the lowering operator for the harmonic oscillator. The description in terms of phase diffusion will occurs however in context of continuous observation of the field exiting the cavity. In this sense, the non-coherence process description as a quantum phase diffusion corresponds to an realization of the evolution described by the master equation, in terms of a stochastic Schroedinger equation. We will demonstrate that the average on many realizations corresponds exactly to the result obtained from the master equation

Diffraction coherence in optics

CERN Document Server

Françon, M; Green, L L

2013-01-01

Diffraction: Coherence in Optics presents a detailed account of the course on Fraunhofer diffraction phenomena, studied at the Faculty of Science in Paris. The publication first elaborates on Huygens' principle and diffraction phenomena for a monochromatic point source and diffraction by an aperture of simple form. Discussions focus on diffraction at infinity and at a finite distance, simplified expressions for the field, calculation of the path difference, diffraction by a rectangular aperture, narrow slit, and circular aperture, and distribution of luminous flux in the airy spot. The book th

Imaging actinic keratosis by high-definition optical coherence tomography. Histomorphologic correlation

DEFF Research Database (Denmark)

Boone, Marc A L M; Norrenberg, Sarah; Jemec, Gregor B E

2013-01-01

With the continued development of non-invasive therapies for actinic keratosis such as PDT and immune therapies, the non-invasive diagnosis and monitoring become increasingly relevant. High-definition optical coherence tomography is a high-resolution imaging tool, with micrometre resolution in both...... transversal and axial directions, enable to visualize individual cells up to a depth of around 570 μm filling the imaging gap between conventional optical coherence tomography and reflectance confocal microscopy. We sought to determine the feasibility of detecting and grading of actinic keratosis...... by this technique using criteria defined for reflectance confocal microscopy compared to histology. In this pilot study, skin lesions of 17 patients with a histologically proven actinic keratosis were imaged by high-definition optical coherence tomography just before excision and images analysed qualitatively...

Evaluation of coherence interference in optical wireless communication through multiscattering channels.

Science.gov (United States)

Kedar, Debbie; Arnon, Shlomi

2006-05-10

Optical wireless communication has been the subject of much research in recent years because of the increasing interest in laser satellite-ground links and urban optical wireless communication. The major sources of performance degradation have been identified as the spatial, angular, and temporal spread of the propagating beam when the propagation channel is multiscattering, resulting in reduced power reception and intersignal interference, as well as turbulence-induced scintillations and noise due to receiver circuitry and background illumination. However, coherence effects due to multipath interference caused by a scattering propagation channel do not appear to have been treated in detail in the scientific literature. We attempt a theoretical analysis of coherence interference in optical wireless communication through scattering channels and try to quantify the resultant performance degradation for different media. We conclude that coherence interference is discernible in optical wireless communication through scattering channels and is highly dependent on the microscopic nature of the propagation medium.

Posterior lattice degeneration characterized by spectral domain optical coherence tomography.

Science.gov (United States)

Manjunath, Varsha; Taha, Mohammed; Fujimoto, James G; Duker, Jay S

2011-03-01

The purpose of this study was to use high-resolution spectral domain optical coherence tomography in the characterization of retinal and vitreal morphological changes overlying posterior lattice degeneration. A cross-sectional retrospective analysis was performed on 13 eyes of 13 nonconsecutive subjects with posterior lattice degeneration seen at the New England Eye Center, Tufts Medical Center between October 2009 and January 2010. Spectral domain optical coherence tomography images taken through the region of lattice degeneration were qualitatively analyzed. Four characteristic changes of the retina and vitreous were seen in the 13 eyes with lattice degeneration: 1) anterior/posterior U-shaped vitreous traction; 2) retinal breaks; 3) focal retinal thinning; and 4) vitreous membrane formation. The morphologic appearance of vitreous traction and retinal breaks were found to be consistent with previous histologic reports. It is possible to image posterior lattice degeneration in many eyes using spectral domain optical coherence tomography and to visualize the spectrum of retinal and vitreous changes throughout the area of lattice degeneration.

Spectral-domain optical coherence tomography on a silicon chip

NARCIS (Netherlands)

Akça, B.I.

2012-01-01

Optical coherence tomography (OCT) is a non-invasive optical technique for high-resolution cross-sectional imaging of specimens, with many applications in clinical medicine and industry (e.g. materials testing, quality assurance, and process control). Current state-of-the-art OCT systems operate in

Performance analysis of coherent free space optical communications with sequential pyramid wavefront sensor

Science.gov (United States)

Liu, Wei; Yao, Kainan; Chen, Lu; Huang, Danian; Cao, Jingtai; Gu, Haijun

2018-03-01

Based-on the previous study on the theory of the sequential pyramid wavefront sensor (SPWFS), in this paper, the SPWFS is first applied to the coherent free space optical communications (FSOC) with more flexible spatial resolution and higher sensitivity than the Shack-Hartmann wavefront sensor, and with higher uniformity of intensity distribution and much simpler than the pyramid wavefront sensor. Then, the mixing efficiency (ME) and the bit error rate (BER) of the coherent FSOC are analyzed during the aberrations correction through numerical simulation with binary phase shift keying (BPSK) modulation. Finally, an experimental AO system based-on SPWFS is setup, and the experimental data is used to analyze the ME and BER of homodyne detection with BPSK modulation. The results show that the AO system based-on SPWFS can increase ME and decrease BER effectively. The conclusions of this paper provide a new method of wavefront sensing for designing the AO system for a coherent FSOC system.

Optical coherence tomography as a diagnostic tool

CSIR Research Space (South Africa)

Singh, A

2011-07-01

Full Text Available Optical Coherence Tomography (OCT) has been used in biomedical applications as a method to non-invasively detect changes occurring in tissue such as the detection of skin cancer. The effect of skin tone on detection of skin cancer has however...

Damping coherent phase oscillations by means of path-length modulation

International Nuclear Information System (INIS)

Rees, J.R.

1978-06-01

Multi-bunch storage rings and synchrotrons are typically plagued by a tendency for the bunches to indulge in unstable coherent phase oscillations engendered by their electromagnetic interactions with the vacuum chamber. In many machines feedback systems have been used successfully to damp these oscillations using a signal proportional to the coherent phase motion or the concomitant energy motion to control an auxiliary longitudinal electric field. The purpose of this note is to describe an alternative feedback system which, using the same kind of a signal, modulates the path length of the orbit of the reference particle (the synchronous particle in the absence of coherent phase oscillations) in such a way as to damp coherent oscillations. 2 refs., 1 fig

Measurement of morphing wing deflection by a cross-coherence fiber optic interferometric technique

Science.gov (United States)

Tomić, Miloš C.; Djinović, Zoran V.; Scheerer, Michael; Petricevic, Slobodan J.

2018-01-01

A fiber-optic interferometric technique aimed at measuring the deflection of aircrafts’ morphing wings is presented. The wing deflection induces a strain in the sensing fiber optic coils that are firmly fixed onto the wing. A change of the phase angle of the light propagating through the fiber is measured by an ‘all-in-fiber’ Michelson interferometer based on a 3 × 3 fiber-optic coupler. Two light sources of different coherence lengths and wavelengths are simultaneously used to ensure a wide measurement range and high accuracy. A new technique for determination of the zero deflection point using the cross-correlation of the two interferograms is proposed. The experiments performed on a specimen made of a carbon-fiber-reinforced plastic honeycomb structure demonstrated a relative uncertainty morphing wing deflection.

International workshop on phase retrieval and coherent scattering. Coherence 2005

International Nuclear Information System (INIS)

Nugent, K.A.; Fienup, J.R.; Van Dyck, D.; Van Aert, S.; Weitkamp, T.; Diaz, A.; Pfeiffer, F.; Cloetens, P.; Stampanoni, M.; Bunk, O.; David, C.; Bronnikov, A.V.; Shen, Q.; Xiao, X.; Gureyev, T.E.; Nesterets, Ya.I.; Paganin, D.M.; Wilkins, S.W.; Mokso, R.; Cloetens, P.; Ludwig, W.; Hignette, O.; Maire, E.; Faulkner, H.M.L.; Rodenburg, J.M.; Wu, X.; Liu, H.; Grubel, G.; Ludwig, K.F.; Livet, F.; Bley, F.; Simon, J.P.; Caudron, R.; Le Bolloc'h, D.; Moussaid, A.; Gutt, C.; Sprung, M.; Madsen, A.; Tolan, M.; Sinha, S.K.; Scheffold, F.; Schurtenberger, P.; Robert, A.; Madsen, A.; Falus, P.; Borthwick, M.A.; Mochrie, S.G.J.; Livet, F.; Sutton, M.D.; Ehrburger-Dolle, F.; Bley, F.; Geissler, E.; Sikharulidze, I.; Jeu, W.H. de; Lurio, L.B.; Hu, X.; Jiao, X.; Jiang, Z.; Lurio, L.B.; Hu, X.; Jiao, X.; Jiang, Z.; Naryanan, S.; Sinha, S.K.; Lal, J.; Naryanan, S.; Sinha, S.K.; Lal, J.; Robinson, I.K.; Chapman, H.N.; Barty, A.; Beetz, T.; Cui, C.; Hajdu, J.; Hau-Riege, S.P.; He, H.; Stadler, L.M.; Sepiol, B.; Harder, R.; Robinson, I.K.; Zontone, F.; Vogl, G.; Howells, M.; London, R.; Marchesini, S.; Shapiro, D.; Spence, J.C.H.; Weierstall, U.; Eisebitt, S.; Shapiro, D.; Lima, E.; Elser, V.; Howells, M.R.; Huang, X.; Jacobsen, C.; Kirz, J.; Miao, H.; Neiman, A.; Sayre, D.; Thibault, P.; Vartanyants, I.A.; Robinson, I.K.; Onken, J.D.; Pfeifer, M.A.; Williams, G.J.; Pfeiffer, F.; Metzger, H.; Zhong, Z.; Bauer, G.; Nishino, Y.; Miao, J.; Kohmura, Y.; Yamamoto, M.; Takahashi, Y.; Koike, K.; Ebisuzaki, T.; Ishikawa, T.; Spence, J.C.H.; Doak, B.

2005-01-01

The contributions of the participants have been organized into 3 topics: 1) phase retrieval methods, 2) X-ray photon correlation spectroscopy, and 3) coherent diffraction imaging. This document gathers the abstracts of the presentations and of the posters

International workshop on phase retrieval and coherent scattering. Coherence 2005

Energy Technology Data Exchange (ETDEWEB)

Nugent, K.A.; Fienup, J.R.; Van Dyck, D.; Van Aert, S.; Weitkamp, T.; Diaz, A.; Pfeiffer, F.; Cloetens, P.; Stampanoni, M.; Bunk, O.; David, C.; Bronnikov, A.V.; Shen, Q.; Xiao, X.; Gureyev, T.E.; Nesterets, Ya.I.; Paganin, D.M.; Wilkins, S.W.; Mokso, R.; Cloetens, P.; Ludwig, W.; Hignette, O.; Maire, E.; Faulkner, H.M.L.; Rodenburg, J.M.; Wu, X.; Liu, H.; Grubel, G.; Ludwig, K.F.; Livet, F.; Bley, F.; Simon, J.P.; Caudron, R.; Le Bolloc' h, D.; Moussaid, A.; Gutt, C.; Sprung, M.; Madsen, A.; Tolan, M.; Sinha, S.K.; Scheffold, F.; Schurtenberger, P.; Robert, A.; Madsen, A.; Falus, P.; Borthwick, M.A.; Mochrie, S.G.J.; Livet, F.; Sutton, M.D.; Ehrburger-Dolle, F.; Bley, F.; Geissler, E.; Sikharulidze, I.; Jeu, W.H. de; Lurio, L.B.; Hu, X.; Jiao, X.; Jiang, Z.; Lurio, L.B.; Hu, X.; Jiao, X.; Jiang, Z.; Naryanan, S.; Sinha, S.K.; Lal, J.; Naryanan, S.; Sinha, S.K.; Lal, J.; Robinson, I.K.; Chapman, H.N.; Barty, A.; Beetz, T.; Cui, C.; Hajdu, J.; Hau-Riege, S.P.; He, H.; Stadler, L.M.; Sepiol, B.; Harder, R.; Robinson, I.K.; Zontone, F.; Vogl, G.; Howells, M.; London, R.; Marchesini, S.; Shapiro, D.; Spence, J.C.H.; Weierstall, U.; Eisebitt, S.; Shapiro, D.; Lima, E.; Elser, V.; Howells, M.R.; Huang, X.; Jacobsen, C.; Kirz, J.; Miao, H.; Neiman, A.; Sayre, D.; Thibault, P.; Vartanyants, I.A.; Robinson, I.K.; Onken, J.D.; Pfeifer, M.A.; Williams, G.J.; Pfeiffer, F.; Metzger, H.; Zhong, Z.; Bauer, G.; Nishino, Y.; Miao, J.; Kohmura, Y.; Yamamoto, M.; Takahashi, Y.; Koike, K.; Ebisuzaki, T.; Ishikawa, T.; Spence, J.C.H.; Doak, B

2005-07-01

The contributions of the participants have been organized into 3 topics: 1) phase retrieval methods, 2) X-ray photon correlation spectroscopy, and 3) coherent diffraction imaging. This document gathers the abstracts of the presentations and of the posters.

Dispersion free full range spectral intensity optical coherence tomography

DEFF Research Database (Denmark)

Jensen, Mikkel; Israelsen, Niels Møller; Maria, Michael

2017-01-01

Optical coherence tomography (OCT) is a non-invasive imaging technique with many applications and widespread use in ophthalmology [1]. The axial resolution in OCT is inversely proportional to the bandwidth of the optical source used, but the improved axial resolution comes at the price of more...

MEMS-based non-rotatory circumferential scanning optical probe for endoscopic optical coherence tomography

Science.gov (United States)

Xu, Yingshun; Singh, Janak; Siang, Teo Hui; Ramakrishna, Kotlanka; Premchandran, C. S.; Sheng, Chen Wei; Kuan, Chuah Tong; Chen, Nanguang; Olivo, Malini C.; Sheppard, Colin J. R.

2007-07-01

In this paper, we present a non-rotatory circumferential scanning optical probe integrated with a MEMS scanner for in vivo endoscopic optical coherence tomography (OCT). OCT is an emerging optical imaging technique that allows high resolution cross-sectional imaging of tissue microstructure. To extend its usage to endoscopic applications, a miniaturized optical probe based on Microelectromechanical Systems (MEMS) fabrication techniques is currently desired. A 3D electrothermally actuated micromirror realized using micromachining single crystal silicon (SCS) process highlights its very large angular deflection, about 45 degree, with low driving voltage for safety consideration. The micromirror is integrated with a GRIN lens into a waterproof package which is compatible with requirements for minimally invasive endoscopic procedures. To implement circumferential scanning substantially for diagnosis on certain pathological conditions, such as Barret's esophagus, the micromirror is mounted on 90 degree to optical axis of GRIN lens. 4 Bimorph actuators that are connected to the mirror on one end via supporting beams and springs are selected in this micromirror design. When actuators of the micromirror are driven by 4 channels of sinusoidal waveforms with 90 degree phase differences, beam focused by a GRIN is redirected out of the endoscope by 45 degree tilting mirror plate and achieve circumferential scanning pattern. This novel driving method making full use of very large angular deflection capability of our micromirror is totally different from previously developed or developing micromotor-like rotatory MEMS device for circumferential scanning.

High-speed optical coherence tomography by circular interferometric ranging

Science.gov (United States)

Siddiqui, Meena; Nam, Ahhyun S.; Tozburun, Serhat; Lippok, Norman; Blatter, Cedric; Vakoc, Benjamin J.

2018-02-01

Existing three-dimensional optical imaging methods excel in controlled environments, but are difficult to deploy over large, irregular and dynamic fields. This means that they can be ill-suited for use in areas such as material inspection and medicine. To better address these applications, we developed methods in optical coherence tomography to efficiently interrogate sparse scattering fields, that is, those in which most locations (voxels) do not generate meaningful signal. Frequency comb sources are used to superimpose reflected signals from equispaced locations through optical subsampling. This results in circular ranging, and reduces the number of measurements required to interrogate large volumetric fields. As a result, signal acquisition barriers that have limited speed and field in optical coherence tomography are avoided. With a new ultrafast, time-stretched frequency comb laser design operating with 7.6 MHz to 18.9 MHz repetition rates, we achieved imaging of multi-cm3 fields at up to 7.5 volumes per second.

Fiber optic-based optical coherence tomography (OCT) for dental applications

Science.gov (United States)

Everett, Matthew J.; Colston, Bill W., Jr.; Da Silva, Luiz B.; Otis, Linda L.

1998-09-01

We have developed a hand-held fiber optic based optical coherence tomography (OCT) system for scanning of the oral cavity. We have produced, using this scanning device, in vivo cross-sectional images of hard and soft dental tissues in human volunteers. Clinically relevant anatomical structures, including the gingival margin, periodontal sulcus, and dento- enamel junction, were visible in all the images. The cemento- enamel junction and the alveolar bone were identified in approximately two thirds of the images. These images represent, or our knowledge, the first in vivo OCT images of human dental tissue.

Fiber optic based optical coherence tomography (OCT) for dental applications

Energy Technology Data Exchange (ETDEWEB)

Everett, M. J., LLNL

1998-06-02

We have developed a hand-held fiber optic based optical coherence tomography (OCT) system for scanning of the oral cavity We have produced, using this scanning device, in viva cross-sectional images of hard and soft dental tissues in human volunteers Clinically relevant anatomical structures, including the gingival margin, periodontal sulcus, and dento-enamel junction, were visible in all the images The dento-enamel junction and the alveolar bone were identifiable in approximately two thirds of the images These images represent, to our knowledge, the first in viva OCT images of human dental tissue.

Coherent and squeezed states in phase space

International Nuclear Information System (INIS)

Jannussis, A.; Bartzis, V.; Vlahos, E.

1990-01-01

In the present paper, the coherent and the squeezed states in phase space have been studied. From the wave functions of the coherent and the squeezed state, their corresponding Wigner distribution functions are calculated. Especially the calculation of the corresponding Wigner functions for the above states permits the determination of the mean values of position and momentum and thus the Heisenberg uncertainty relation. In fact, from the related results, it is concluded that the uncertainty relation of the coherent and associated squeezed states is the same

Coherent dynamics of interwell excitons in GaAs/AlxGa1-xAs superlattices

DEFF Research Database (Denmark)

Mizeikis, V.; Birkedal, Dan; Langbein, Wolfgang Werner

1997-01-01

Coherent exciton dynamics in a GaAs/AlxGa1-xAs narrow-miniband superlattice is studied by spectrally resolved transient four-wave mixing. Coherent optical properties of the investigated structure are found to be strongly affected by the existence of two different heavy-hole excitonic states. One...

Gated frequency-resolved optical imaging with an optical parametric amplifier for medical applications

Energy Technology Data Exchange (ETDEWEB)

Cameron, S.M.; Bliss, D.E.

1997-02-01

Implementation of optical imagery in a diffuse inhomogeneous medium such as biological tissue requires an understanding of photon migration and multiple scattering processes which act to randomize pathlength and degrade image quality. The nature of transmitted light from soft tissue ranges from the quasi-coherent properties of the minimally scattered component to the random incoherent light of the diffuse component. Recent experimental approaches have emphasized dynamic path-sensitive imaging measurements with either ultrashort laser pulses (ballistic photons) or amplitude modulated laser light launched into tissue (photon density waves) to increase image resolution and transmissive penetration depth. Ballistic imaging seeks to compensate for these {open_quotes}fog-like{close_quotes} effects by temporally isolating the weak early-arriving image-bearing component from the diffusely scattered background using a subpicosecond optical gate superimposed on the transmitted photon time-of-flight distribution. The authors have developed a broadly wavelength tunable (470 nm -2.4 {mu}m), ultrashort amplifying optical gate for transillumination spectral imaging based on optical parametric amplification in a nonlinear crystal. The time-gated image amplification process exhibits low noise and high sensitivity, with gains greater than 104 achievable for low light levels. We report preliminary benchmark experiments in which this system was used to reconstruct, spectrally upcovert, and enhance near-infrared two-dimensional images with feature sizes of 65 {mu}m/mm{sup 2} in background optical attenuations exceeding 10{sup 12}. Phase images of test objects exhibiting both absorptive contrast and diffuse scatter were acquired using a self-referencing Shack-Hartmann wavefront sensor in combination with short-pulse quasi-ballistic gating. The sensor employed a lenslet array based on binary optics technology and was sensitive to optical path distortions approaching {lambda}/100.

Fiber-optic polarization diversity detection for rotary probe optical coherence tomography.

Science.gov (United States)

Lee, Anthony M D; Pahlevaninezhad, Hamid; Yang, Victor X D; Lam, Stephen; MacAulay, Calum; Lane, Pierre

2014-06-15

We report a polarization diversity detection scheme for optical coherence tomography with a new, custom, miniaturized fiber coupler with single mode (SM) fiber inputs and polarization maintaining (PM) fiber outputs. The SM fiber inputs obviate matching the optical lengths of the X and Y OCT polarization channels prior to interference and the PM fiber outputs ensure defined X and Y axes after interference. Advantages for this scheme include easier alignment, lower cost, and easier miniaturization compared to designs with free-space bulk optical components. We demonstrate the utility of the detection system to mitigate the effects of rapidly changing polarization states when imaging with rotating fiber optic probes in Intralipid suspension and during in vivo imaging of human airways.

Complex regression Doppler optical coherence tomography

Science.gov (United States)

Elahi, Sahar; Gu, Shi; Thrane, Lars; Rollins, Andrew M.; Jenkins, Michael W.

2018-04-01

We introduce a new method to measure Doppler shifts more accurately and extend the dynamic range of Doppler optical coherence tomography (OCT). The two-point estimate of the conventional Doppler method is replaced with a regression that is applied to high-density B-scans in polar coordinates. We built a high-speed OCT system using a 1.68-MHz Fourier domain mode locked laser to acquire high-density B-scans (16,000 A-lines) at high enough frame rates (˜100 fps) to accurately capture the dynamics of the beating embryonic heart. Flow phantom experiments confirm that the complex regression lowers the minimum detectable velocity from 12.25 mm / s to 374 μm / s, whereas the maximum velocity of 400 mm / s is measured without phase wrapping. Complex regression Doppler OCT also demonstrates higher accuracy and precision compared with the conventional method, particularly when signal-to-noise ratio is low. The extended dynamic range allows monitoring of blood flow over several stages of development in embryos without adjusting the imaging parameters. In addition, applying complex averaging recovers hidden features in structural images.

XIX International Youth School on Coherent Optics and Optical Spectroscopy

International Nuclear Information System (INIS)

2016-01-01

The XIX International Youth School on Coherent Optics and Optical Spectroscopy (COOS2015) was held in Kazan, Russia, from October 5 to October 7 at the Nikolai Lobachevsky Scientific Library of Kazan Federal University. The School follows the global tendency toward comprehensive studies of matter properties and its interaction with electromagnetic fields. Since 1997 more than 100 famous scientists from USA, Germany, Ukraine, Belarussia and Russia had plenary lecture presentations. This is the right place, where over 1000 young scientists had an opportunity to participate in hot discussions regarding the latest scientific news. Many young people have submitted interesting reports on photonics, quantum electronics, laser physics, quantum optics, traditional optical and laser spectroscopy, non-linear optics, material science and nanotechnology. Here we are publishing the full-size papers prepared from the most interesting lectures and reports selected by the Program Committee of the School. (paper)

Classifying murine glomerulonephritis using optical coherence tomography and optical coherence elastography.

Science.gov (United States)

Liu, Chih-Hao; Du, Yong; Singh, Manmohan; Wu, Chen; Han, Zhaolong; Li, Jiasong; Chang, Anthony; Mohan, Chandra; Larin, Kirill V

2016-08-01

Acute glomerulonephritis caused by antiglomerular basement membrane marked by high mortality. The primary reason for this is delayed diagnosis via blood examination, urine analysis, tissue biopsy, or ultrasound and X-ray computed tomography imaging. Blood, urine, and tissue-based diagnoses can be time consuming, while ultrasound and CT imaging have relatively low spatial resolution, with reduced sensitivity. Optical coherence tomography is a noninvasive and high-resolution imaging technique that provides superior spatial resolution (micrometer scale) as compared to ultrasound and CT. Changes in tissue properties can be detected based on the optical metrics analyzed from the OCT signals, such as optical attenuation and speckle variance. Furthermore, OCT does not rely on ionizing radiation as with CT imaging. In addition to structural changes, the elasticity of the kidney can significantly change due to nephritis. In this work, OCT has been utilized to quantify the difference in tissue properties between healthy and nephritic murine kidneys. Although OCT imaging could identify the diseased tissue, its classification accuracy is clinically inadequate. By combining optical metrics with elasticity, the classification accuracy improves from 76% to 95%. These results show that OCT combined with OCE can be a powerful tool for identifying and classifying nephritis. Therefore, the OCT/OCE method could potentially be used as a minimally invasive tool for longitudinal studies during the progression and therapy of glomerulonephritis as well as complement and, perhaps, substitute highly invasive tissue biopsies. Elastic-wave propagation in mouse healthy and nephritic kidneys. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Optical coherence tomography a clinical and technical update

CERN Document Server

Cunha-Vaz, José

2012-01-01

Optical Coherence Tomography represents the ultimate noninvasive  ocular imaging technique although being in the field for over two-decades. This book encompasses both medical and technical developments and recent achievements. Here, the authors cover the field of application from the anterior to the posterior ocular segments (Part I) and present a comprehensive review on the development of OCT. Important developments towards  clinical applications are covered in Part II, ranging from the adaptive optics to the integration on a slit-lamp, and passing through new structural  and functional information extraction from OCT data. The book is intended to be informative, coherent and comprehensive for both the medical and technical communities and aims at easing the communication between the two fields and bridging the gap between the two scientific communities.

Experimental study of non-binary LDPC coding for long-haul coherent optical QPSK transmissions.

Science.gov (United States)

Zhang, Shaoliang; Arabaci, Murat; Yaman, Fatih; Djordjevic, Ivan B; Xu, Lei; Wang, Ting; Inada, Yoshihisa; Ogata, Takaaki; Aoki, Yasuhiro

2011-09-26

The performance of rate-0.8 4-ary LDPC code has been studied in a 50 GHz-spaced 40 Gb/s DWDM system with PDM-QPSK modulation. The net effective coding gain of 10 dB is obtained at BER of 10(-6). With the aid of time-interleaving polarization multiplexing and MAP detection, 10,560 km transmission over legacy dispersion managed fiber is achieved without any countable errors. The proposed nonbinary quasi-cyclic LDPC code achieves an uncoded BER threshold at 4×10(-2). Potential issues like phase ambiguity and coding length are also discussed when implementing LDPC in current coherent optical systems. © 2011 Optical Society of America

Novel coherent supercontinuum light sources based on all-normal dispersion fibers

Energy Technology Data Exchange (ETDEWEB)

Heidt, Alexander

2011-07-05

The concept of broadband coherent supercontinuum (SC) generation in all-normal dispersion (ANDi) fibers in the near-infrared, visible and ultraviolet (UV) spectral regions is introduced and investigated in detail. In numerical studies, explicit design criteria are established for ANDi photonic crystal fiber (PCF) designs that allow the generation of flat and smooth ultrabroad spectral profiles without significant fine structure and with excellent stability and coherence properties. The key benefit of SC generation in ANDi fibers is the conservation of a single ultrashort pulse in the time domain with smooth and recompressible phase distribution. In the numerical investigation of the SC generation dynamics self-phase modulation and optical wave breaking are identified as the dominant nonlinear effects responsible for the nonlinear spectral broadening. It is further demonstrated that coherence properties, spectral bandwidth and temporal compressibility are independent of input pulse duration for constant peak power. The numerical predictions are in excellent agreement with experimental results obtained in two realizations of ANDi PCF optimized for the near-infrared and visible spectral region. In these experiments, the broadest SC spectrum generated in the normal dispersion regime of an optical fiber to date is achieved. The exceptional temporal properties of the generated SC pulses are verified experimentally and their applicability for the time-resolved study of molecular dynamics in ultrafast transient absorption spectroscopy is demonstrated. In an additional nonlinear pulse compression experiment, the SC pulses obtained in a short piece of ANDi PCF could be temporally recompressed to sub-two cycle durations by linear chirp compensation. Numerical simulations show that even shorter pulse durations with excellent quality can be achieved by full phase compensation. The concept is further extended into the UV spectral regime by considering tapered optical fibers with

Imaging of basal cell carcinoma by high-definition optical coherence tomography

DEFF Research Database (Denmark)

Boone, M A L M; Norrenberg, S; Jemec, G B E

2012-01-01

With the continued development of noninvasive therapies for basal cell carcinoma (BCC) such as photodynamic therapy and immune therapies, noninvasive diagnosis and monitoring become increasingly relevant. High-definition optical coherence tomography (HD-OCT) is a high-resolution imaging tool, wit......, with micrometre resolution in both transversal and axial directions, enabling visualization of individual cells up to a depth of around 570 μm, and filling the imaging gap between conventional optical coherence tomography (OCT) and reflectance confocal microscopy (RCM)....

Squeezed light in an optical parametric oscillator network with coherent feedback quantum control.

Science.gov (United States)

Crisafulli, Orion; Tezak, Nikolas; Soh, Daniel B S; Armen, Michael A; Mabuchi, Hideo

2013-07-29

We present squeezing and anti-squeezing spectra of the output from a degenerate optical parametric oscillator (OPO) network arranged in different coherent quantum feedback configurations. One OPO serves as a quantum plant, the other as a quantum controller. The addition of coherent feedback enables shaping of the output squeezing spectrum of the plant, and is found to be capable of pushing the frequency of maximum squeezing away from the optical driving frequency and broadening the spectrum over a wider frequency band. The experimental results are in excellent agreement with the developed theory, and illustrate the use of coherent quantum feedback to engineer the quantum-optical properties of the plant OPO output.

Coherent Femtosecond Spectroscopy and Nonlinear Optical Imaging on the Nanoscale

Science.gov (United States)

Kravtsov, Vasily

Optical properties of many materials and macroscopic systems are defined by ultrafast dynamics of electronic, vibrational, and spin excitations localized on the nanoscale. Harnessing these excitations for material engineering, optical computing, and control of chemical reactions has been a long-standing goal in science and technology. However, it is challenging due to the lack of spectroscopic techniques that can resolve processes simultaneously on the nanometer spatial and femtosecond temporal scales. This thesis describes the fundamental principles, implementation, and experimental demonstration of a novel type of ultrafast microscopy based on the concept of adiabatic plasmonic nanofocusing. Simultaneous spatio-temporal resolution on a nanometer-femtosecond scale is achieved by using a near-field nonlinear optical response induced by ultrafast surface plasmon polaritons nanofocused on a metal tip. First, we study the surface plasmon response in metallic structures and evaluate its prospects and limitations for ultrafast near-field microscopy. Through plasmon emission-based spectroscopy, we investigate dephasing times and interplay between radiative and non-radiative decay rates of localized plasmons and their modification due to coupling. We identify a new regime of quantum plasmonic coupling, which limits the achievable spatial resolution to several angstroms but at the same time provides a potential channel for generating ultrafast electron currents at optical frequencies. Next, we study propagation of femtosecond wavepackets of surface plasmon polaritons on a metal tip. In time-domain interferometric measurements we detect group delays that correspond to slowing of the plasmon polaritons down to 20% of the speed of light at the tip apex. This provides direct experimental verification of the plasmonic nanofocusing mechanism and suggests enhanced nonlinear optical interactions at the tip apex. We then measure a plasmon-generated third-order nonlinear optical

Functional imaging and assessment of the glucose diffusion rate in epithelial tissues in optical coherence tomography

International Nuclear Information System (INIS)

Larin, K V; Tuchin, V V

2008-01-01

Functional imaging, monitoring and quantitative description of glucose diffusion in epithelial and underlying stromal tissues in vivo and controlling of the optical properties of tissues are extremely important for many biomedical applications including the development of noninvasive or minimally invasive glucose sensors as well as for therapy and diagnostics of various diseases, such as cancer, diabetic retinopathy, and glaucoma. Recent progress in the development of a noninvasive molecular diffusion biosensor based on optical coherence tomography (OCT) is described. The diffusion of glucose was studied in several epithelial tissues both in vitro and in vivo. Because OCT provides depth-resolved imaging of tissues with high in-depth resolution, the glucose diffusion is described not only as a function of time but also as a function of depth. (special issue devoted to application of laser technologies in biophotonics and biomedical studies)

Physical optics simulations with PHASE for SwissFEL beamlines

Energy Technology Data Exchange (ETDEWEB)

Flechsig, U.; Follath, R.; Reiche, S. [Paul Scherrer Institut, Swiss Light Source, 5232 Villigen PSI (Switzerland); Bahrdt, J. [Helmholtz Zentrum Berlin (Germany)

2016-07-27

PHASE is a software tool for physical optics simulation based on the stationary phase approximation method. The code is under continuous development since about 20 years and has been used for instance for fundamental studies and ray tracing of various beamlines at the Swiss Light Source. Along with the planning for SwissFEL a new hard X-ray free electron laser under construction, new features have been added to permit practical performance predictions including diffraction effects which emerge with the fully coherent source. We present the application of the package on the example of the ARAMIS 1 beamline at SwissFEL. The X-ray pulse calculated with GENESIS and given as an electrical field distribution has been propagated through the beamline to the sample position. We demonstrate the new features of PHASE like the treatment of measured figure errors, apertures and coatings of the mirrors and the application of Fourier optics propagators for free space propagation.

Discrimination of binary coherent states using a homodyne detector and a photon number resolving detector

DEFF Research Database (Denmark)

Wittmann, Christoffer; Andersen, Ulrik Lund; Takeoka, Masahiro

2010-01-01

We investigate quantum measurement strategies capable of discriminating two coherent states probabilistically with significantly smaller error probabilities than can be obtained using nonprobabilistic state discrimination. We apply a postselection strategy to the measurement data of a homodyne...... detector as well as a photon number resolving detector in order to lower the error probability. We compare the two different receivers with an optimal intermediate measurement scheme where the error rate is minimized for a fixed rate of inconclusive results. The photon number resolving (PNR) receiver...

Miniature endoscopic optical coherence tomography for calculus detection.

Science.gov (United States)

Kao, Meng-Chun; Lin, Chun-Li; Kung, Che-Yen; Huang, Yi-Fung; Kuo, Wen-Chuan

2015-08-20

The effective treatment of periodontitis involves the detection and removal of subgingival dental calculus. However, subgingival calculus is more difficult to detect than supragingival calculus because it is firmly attached to root surfaces within periodontal pockets. To achieve a smooth root surface, clinicians often remove excessive amounts of root structure because of decreased visibility. In addition, enamel pearl, a rare type of ectopic enamel formation on the root surface, can easily be confused with dental calculus in the subgingival environment. In this study, we developed a fiber-probe swept-source optical coherence tomography (SSOCT) technique and combined it with the quantitative measurement of an optical parameter [standard deviation (SD) of the optical coherence tomography (OCT) intensity] to differentiate subgingival calculus from sound enamel, including enamel pearl. Two-dimensional circumferential images were constructed by rotating the miniprobe (0.9 mm diameter) while acquiring image lines, and the adjacent lines in each rotation were stacked to generate a three-dimensional volume. In OCT images, compared to sound enamel and enamel pearls, dental calculus showed significant differences (Pdental calculus.

In-vivo imaging of blood flow in human retinal vessels using color Doppler optical coherence tomography

Science.gov (United States)

Yazdanfar, Siavash; Rollins, Andrew M.; Izatt, Joseph A.

1999-04-01

Quantification of retinal blood flow may lead to a better understanding of the progression and treatment of several ocular disorders, including diabetic retinopathy, age- related macular degeneration, and glaucoma. Current techniques, such as fluorescein angiography and laser Doppler velocimetry are limited, failing to provide sufficient information to the clinician. Color Doppler optical coherence tomography (CDOCT) is a novel technique using coherent heterodyne detection for simultaneous cross- sectional imaging of tissue microstructure and blood flow. This technique is capable of high spatial and velocity resolution imaging in highly scattering media. We implemented CDOCT for retinal blood flow mapping in human subjects. No dilation of the pupil was necessary. CDOCT is demonstrated for determining bidirectional flow in sub- 100micrometers diameter vessels in the retina. Additionally, we calculated Doppler broadening using the variance of depth- resolved spectra to identify regions with large velocity gradients within the Xenopus heart. This technique may be useful in quantifying local tissue perfusion in highly vascular retinal tissue.

Stimulated coherent transition radiation

International Nuclear Information System (INIS)

Hung-chi Lihn.

1996-03-01

Coherent radiation emitted from a relativistic electron bunch consists of wavelengths longer than or comparable to the bunch length. The intensity of this radiation out-numbers that of its incoherent counterpart, which extends to wavelengths shorter than the bunch length, by a factor equal to the number of electrons in the bunch. In typical accelerators, this factor is about 8 to 11 orders of magnitude. The spectrum of the coherent radiation is determined by the Fourier transform of the electron bunch distribution and, therefore, contains information of the bunch distribution. Coherent transition radiation emitted from subpicosecond electron bunches at the Stanford SUNSHINE facility is observed in the far-infrared regime through a room-temperature pyroelectric bolometer and characterized through the electron bunch-length study. To measure the bunch length, a new frequency-resolved subpicosecond bunch-length measuring system is developed. This system uses a far-infrared Michelson interferometer to measure the spectrum of coherent transition radiation through optical autocorrelation with resolution far better than existing time-resolved methods. Hence, the radiation spectrum and the bunch length are deduced from the autocorrelation measurement. To study the stimulation of coherent transition radiation, a special cavity named BRAICER is invented. Far-infrared light pulses of coherent transition radiation emitted from electron bunches are delayed and circulated in the cavity to coincide with subsequent incoming electron bunches. This coincidence of light pulses with electron bunches enables the light to do work on electrons, and thus stimulates more radiated energy. The possibilities of extending the bunch-length measuring system to measure the three-dimensional bunch distribution and making the BRAICER cavity a broadband, high-intensity, coherent, far-infrared light source are also discussed

Evaluation of retinal nerve fiber layer thickness measurements using optical coherence tomography in patients with tobacco-alcohol-induced toxic optic neuropathy

Directory of Open Access Journals (Sweden)

Moura Frederico

2010-01-01

Full Text Available Three patients with progressive visual loss, chronic alcoholism and tabagism were submitted to a complete neuro-ophthalmic examination and to retinal nerve fiber layer (RNFL measurements using optical coherence tomography (OCT scanning. Two patients showed marked RNFL loss in the temporal sector of the optic disc. However, a third patient presented RNFL measurements within or above normal limits, based on the Stratus-OCT normative database. Such findings may be due to possible RNFL edema similar to the one that may occur in the acute phase of toxic optic neuropathies. Stratus-OCT was able to detect RNFL loss in the papillomacular bundle of patients with tobacco-alcohol-induced toxic optic neuropathy. However, interpretation must be careful when OCT does not show abnormality in order to prevent diagnostic confusion, since overestimation of RNFL thickness measurements is possible in such cases.

Optical coherence tomographic view of persistent primary fetal vasculature

International Nuclear Information System (INIS)

Shenoy, R.; Al-Kharousi, Nadia S.; Bialasiewicz, Alexander A.

2006-01-01

Purpose was to report on the posterior segment changes in a patient with bilateral persistent primary fetal vasculature as detected by optical coherence tomography. An 18-year-old lady with poor vision, left esotropia and bilateral posterior polar cataract was found to have dysplasia of the macula in the both eyes. Fundus fluorescein angiography, optical coherence tomography, ''A'' scan biometry and genetic work up was performed as a part of investigation. There was increase in thickness of the macular area in both the eyes (450-500mm). The left eye showed a ''sail like'' fold extending over macula, from nasal to temporal side. The tissue had the same sensitivity and thickness as inner the retinal layers (180-200). There was no detectable nerve fibre layer in the macula of either eye. Fundus fluorescein angiography was normal in the right eye, and showed hyperfluorescence at the inferior pole of the disk in the left eye corresponding to the Bergmeister papilla. There was no staining of the membrane with the dye. Evaluation of the posterior segment is important in predicting the visual outcome in patients with any from of PFV. Optical coherence tomography is an adjuvant to direct visualization and aids in further delineating posterior segment changes seen in this condition. (author)

MMIC tuned front-end for a coherent optical receiver

DEFF Research Database (Denmark)

Petersen, Anders Kongstad; Jagd, A. M.; Ebskamp, F.

1993-01-01

A low-noise transformer tuned optical front-end for a coherent optical receiver is described. The front-end is based on a GaInAs/InP p-i-n photodiode and a full custom designed GaAs monolithic microwave integrated circuit (MMIC). The measured equivalent input noise current density is between 5-16 p...

Quantum mechanics in coherent algebras on phase space

International Nuclear Information System (INIS)

Lesche, B.; Seligman, T.H.

1986-01-01

Quantum mechanics is formulated on a quantum mechanical phase space. The algebra of observables and states is represented by an algebra of functions on phase space that fulfills a certain coherence condition, expressing the quantum mechanical superposition principle. The trace operation is an integration over phase space. In the case where the canonical variables independently run from -infinity to +infinity the formalism reduces to the representation of quantum mechanics by Wigner distributions. However, the notion of coherent algebras allows to apply the formalism to spaces for which the Wigner mapping is not known. Quantum mechanics of a particle in a plane in polar coordinates is discussed as an example. (author)

Femtosecond Time-resolved Optical Polarigraphy (FTOP)

International Nuclear Information System (INIS)

Aoshima, S.; Fujimoto, M.; Hosoda, M.; Tsuchiya, Y.

2000-01-01

A novel time-resolved imaging technique named FTOP (Femtosecond Time-resolved Optical Polarigraphy) for visualizing the ultrafast propagation dynamics of intense light pulses in a medium has been proposed and demonstrated. Femtosecond snapshot images can be created with a high spatial resolution by imaging only the polarization components of the probe pulse; these polarization components change due to the instantaneous birefringence induced by the pump pulse in the medium. Ultrafast temporal changes in the two-dimensional spatial distribution of the optical pulse intensity were clearly visualized in consecutive images by changing the delay between the pump and probe. We observe that several filaments appear and then come together before the vacuum focus due to nonlinear effects in air. We also prove that filamentation dynamics such as the formation position and the propagation behavior are complex and are strongly affected by the pump energy. The results collected clearly show that this method FTOP succeeds for the first time in directly visualizing the ultrafast dynamics of the self-modulated nonlinear propagation of light. (author)

Three-dimensional, time-resolved profiling of ferroelectric domain wall dynamics by spectral-domain optical coherence tomography

International Nuclear Information System (INIS)

Haussmann, Alexander; Schmidt, Sebastian; Wehmeier, Lukas; Eng, Lukas M.; Kirsten, Lars; Cimalla, Peter; Koch, Edmund

2017-01-01

We apply here spectral-domain optical coherence tomography (SD-OCT) for the precise detection and temporal tracking of ferroelectric domain walls (DWs) in magnesium-doped periodically poled lithium niobate (Mg:PPLN). We reproducibly map static DWs at an axial (depth) resolution down to ∝ 0.6 μm, being located up to 0.5 mm well inside the single crystalline Mg:PPLN sample. We show that a full 3-dimensional (3D) reconstruction of the DW geometry is possible from the collected data, when applying a special algorithm that accounts for the nonlinear optical dispersion of the material. Our OCT investigation provides valuable reference information on the DWs' polarization charge distribution, which is known to be the key to the electrical conductivity of ferroelectric DWs in such systems. Hence, we carefully analyze the SD-OCT signal dependence both when varying the direction of incident polarization, and when applying electrical fields along the polar axis. Surprisingly, the large backreflection intensities recorded under extraordinary polarization are not affected by any electrical field, at least for field strengths below the switching threshold, while no significant signals above noise floor are detected under ordinary polarization. Finally, we employed the high-speed SD-OCT setup for the real-time DW tracking upon ferroelectric domain switching under high external fields. (copyright 2017 by WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

Three-dimensional, time-resolved profiling of ferroelectric domain wall dynamics by spectral-domain optical coherence tomography

Energy Technology Data Exchange (ETDEWEB)

Haussmann, Alexander; Schmidt, Sebastian; Wehmeier, Lukas; Eng, Lukas M. [Technische Universitaet Dresden, Institute of Applied Physics and Center for Advancing Electronics Dresden (cfaed), Dresden (Germany); Kirsten, Lars; Cimalla, Peter; Koch, Edmund [Technische Universitaet Dresden, Faculty of Medicine Carl Gustav Carus, Anesthesiology and Intensive Care Medicine, Clinical Sensoring and Monitoring, Dresden (Germany)

2017-08-15

We apply here spectral-domain optical coherence tomography (SD-OCT) for the precise detection and temporal tracking of ferroelectric domain walls (DWs) in magnesium-doped periodically poled lithium niobate (Mg:PPLN). We reproducibly map static DWs at an axial (depth) resolution down to ∝ 0.6 μm, being located up to 0.5 mm well inside the single crystalline Mg:PPLN sample. We show that a full 3-dimensional (3D) reconstruction of the DW geometry is possible from the collected data, when applying a special algorithm that accounts for the nonlinear optical dispersion of the material. Our OCT investigation provides valuable reference information on the DWs' polarization charge distribution, which is known to be the key to the electrical conductivity of ferroelectric DWs in such systems. Hence, we carefully analyze the SD-OCT signal dependence both when varying the direction of incident polarization, and when applying electrical fields along the polar axis. Surprisingly, the large backreflection intensities recorded under extraordinary polarization are not affected by any electrical field, at least for field strengths below the switching threshold, while no significant signals above noise floor are detected under ordinary polarization. Finally, we employed the high-speed SD-OCT setup for the real-time DW tracking upon ferroelectric domain switching under high external fields. (copyright 2017 by WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

XX International Youth Scientific School “Coherent Optics and Optical Spectroscopy”

International Nuclear Information System (INIS)

2017-01-01

The XX International Youth School on Coherent Optics and Optical Spectroscopy (COOS2016) was held in Kazan, Russia, from October 18 to October 20 on the Nikolai Lobachevsky Scientific Library of Kazan Federal University. The School follows the global tendency to comprehensive studies of matter properties and its interaction with electromagnetic fields. Since 1997 more than 100 famous scientists from USA, Germany, Ukraine, Belarus and Russia had plenary lectures presentations. This is the right place, where over 1000 young scientists had an opportunity to participate in hot discussions of the latest scientific news. Many young people have submitted interesting reports on photonics, quantum electronics, laser physics, quantum optics, traditional optical and laser spectroscopy, non-linear optics, material science and nanotechnology. Here we are publishing the full-size papers prepared from the most interesting lectures and reports selected by the Program Committee of the School. Plenary sessions were offered by the following invited speakers: Ildar Gabitov, University of Arizona, USA. • Error statistics in coherent communication lines Andrei Naumov, Institute for Spectroscopy RAS, Troitsk, Moscow, Russia. • Revisiting the question of the experimental realization of a nonclassical light source on the basis of single organic molecules of dyes Gerd Hermann, University of Giessien, Germany. • Applications of Coherent Spectroscopy Askhat Basharov, National Research Center ‘Kurchatov Institute’, Moscow, Russia. • Low-frequency emission in resonant processes • Evolution of a two-level quantum particle in the noise classical e.-m. field within and beyond the resonant approximation Anastas Bukharaev, Kazan E. K. Zavoisky Physical-Technical Institute, Kazan, Russia. • Straintronics Maxim Gladush, Institute for Spectroscopy RAS, Troitsk, Moscow, Russia. • Fluorescent properties of single quantum emitters and their ensembles in dielectric media Sergey Sazonov

SUPERORBITAL PHASE-RESOLVED ANALYSIS OF SMC X-1

Energy Technology Data Exchange (ETDEWEB)

Hu, Chin-Ping; Chou, Yi; Yang, Ting-Chang; Su, Yi-Hao, E-mail: m929011@astro.ncu.edu.tw, E-mail: yichou@astro.ncu.edu.tw [Graduate Institute of Astronomy, National Central University, Jhongli 32001, Taiwan (China)

2013-08-10

The high-mass X-ray binary SMC X-1 is an eclipsing binary with an orbital period of 3.89 days. This system exhibits a superorbital modulation with a period varying between {approx}40 days and {approx}65 days. The instantaneous frequency and the corresponding phase of the superorbital modulation can be obtained by a recently developed time-frequency analysis technique, the Hilbert-Huang transform (HHT). We present a phase-resolved analysis of both the spectra and the orbital profiles with the superorbital phase derived from the HHT. The X-ray spectra observed by the Proportional Counter Array on board the Rossi X-ray Timing Explorer are fitted well by a blackbody plus a Comptonized component. The plasma optical depth, which is a good indicator of the distribution of material along the line of sight, is significantly anti-correlated with the flux detected at 2.5-25 keV. However, the relationship between the plasma optical depth and the equivalent width of the iron line is not monotonic. There is no significant correlation for fluxes higher than {approx}35 mCrab but clear positive correlation when the intensity is lower than {approx}20 mCrab. This indicates that the iron line production is dominated by different regions of this binary system in different superorbital phases. To study the dependence of the orbital profile on the superorbital phase, we obtained the eclipse profiles by folding the All Sky Monitor light curve with the orbital period for different superorbital states. A dip feature, similar to the pre-eclipse dip in Her X-1, lying at orbital phase {approx}0.6-0.85, was discovered during the superorbital transition state. This indicates that the accretion disk has a bulge that absorbs considerable X-ray emission in the stream-disk interaction region. The dip width is anti-correlated with the flux, and this relation can be interpreted by the precessing tilted accretion disk scenario.

Benign familial fleck retina: multimodal imaging including optical coherence tomography angiography.

Science.gov (United States)

Garcia, Jose Mauricio Botto de Barros; Isaac, David Leonardo Cruvinel; Sardeiro, Tainara; Aquino, Érika; Avila, Marcos

2017-01-01

This report presents multimodal imaging of a 27-year-old woman diagnosed with benign familial fleck retina (OMIM 228980), an uncommon disorder. Fundus photographs revealed retinal flecks that affected her post-equatorial retina but spared the macular area. Fundus autofluorescence and infrared imaging demonstrated a symmetrical pattern of yellow-white fleck lesions that affected both eyes. Her full-field electroretinogram and electrooculogram were normal. An optical coherence tomography B-scan was performed for both eyes, revealing increased thickness of the retinal pigmented epithelium leading to multiple small pigmented epithelium detachments. The outer retina remained intact in both eyes. Spectral-domain optical coherence tomography angiography with split-spectrum amplitude decorrelation algorithm and 3 × 3 mm structural en face optical coherence tomography did not show macular lesions. Benign familial fleck retina belongs to a heterogenous group of so-called flecked retina syndromes, and should be considered in patients with yellowish-white retinal lesions without involvement of the macula.

Benign familial fleck retina: multimodal imaging including optical coherence tomography angiography

Directory of Open Access Journals (Sweden)

Jose Mauricio Botto de Barros Garcia

Full Text Available ABSTRACT This report presents multimodal imaging of a 27-year-old woman diagnosed with benign familial fleck retina (OMIM 228980, an uncommon disorder. Fundus photographs revealed retinal flecks that affected her post-equatorial retina but spared the macular area. Fundus autofluorescence and infrared imaging demonstrated a symmetrical pattern of yellow-white fleck lesions that affected both eyes. Her full-field electroretinogram and electrooculogram were normal. An optical coherence tomography B-scan was performed for both eyes, revealing increased thickness of the retinal pigmented epithelium leading to multiple small pigmented epithelium detachments. The outer retina remained intact in both eyes. Spectral-domain optical coherence tomography angiography with split-spectrum amplitude decorrelation algorithm and 3 × 3 mm structural en face optical coherence tomography did not show macular lesions. Benign familial fleck retina belongs to a heterogenous group of so-called flecked retina syndromes, and should be considered in patients with yellowish-white retinal lesions without involvement of the macula.

High-resolution retinal imaging using adaptive optics and Fourier-domain optical coherence tomography

Science.gov (United States)

Olivier, Scot S.; Werner, John S.; Zawadzki, Robert J.; Laut, Sophie P.; Jones, Steven M.

2010-09-07

This invention permits retinal images to be acquired at high speed and with unprecedented resolution in three dimensions (4.times.4.times.6 .mu.m). The instrument achieves high lateral resolution by using adaptive optics to correct optical aberrations of the human eye in real time. High axial resolution and high speed are made possible by the use of Fourier-domain optical coherence tomography. Using this system, we have demonstrated the ability to image microscopic blood vessels and the cone photoreceptor mosaic.

Retinal pigment epithelium findings in patients with albinism using wide-field polarization-sensitive optical coherence tomography.

Science.gov (United States)

Schütze, Christopher; Ritter, Markus; Blum, Robert; Zotter, Stefan; Baumann, Bernhard; Pircher, Michael; Hitzenberger, Christoph K; Schmidt-Erfurth, Ursula

2014-11-01

To investigate pigmentation characteristics of the retinal pigment epithelium (RPE) in patients with albinism using wide-field polarization-sensitive optical coherence tomography compared with intensity-based spectral domain optical coherence tomography and fundus autofluorescence imaging. Five patients (10 eyes) with previously genetically diagnosed albinism and 5 healthy control subjects (10 eyes) were imaged by a wide-field polarization-sensitive optical coherence tomography system (scan angle: 40 × 40° on the retina), sensitive to melanin contained in the RPE, based on the polarization state of backscattered light. Conventional intensity-based spectral domain optical coherence tomography and fundus autofluorescence examinations were performed. Retinal pigment epithelium-pigmentation was analyzed qualitatively and quantitatively based on depolarization assessed by polarization-sensitive optical coherence tomography. This study revealed strong evidence of polarization-sensitive optical coherence tomography to specifically image melanin in the RPE. Depolarization of light backscattered by the RPE in patients with albinism was reduced compared with normal subjects. Heterogeneous RPE-specific depolarization characteristics were observed in patients with albinism. Reduction of depolarization observed in the light backscattered by the RPE in patients with albinism corresponds to expected decrease of RPE pigmentation. The degree of depigmentation of the RPE is possibly associated with visual acuity. Findings suggest that different albinism genotypes result in heterogeneous levels of RPE pigmentation. Polarization-sensitive optical coherence tomography showed a heterogeneous appearance of RPE pigmentation in patients with albinism depending on different genotypes.

method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands

NARCIS (Netherlands)

Boer, JF De; Tearney, G. J.; Bouma, BE

2008-01-01

Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and loW coher ence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split

Optical coherence tomography of the rat cochlea

NARCIS (Netherlands)

Wong, B. J. F.; de Boer, JF; Park, B.H.; Chen, ZP; Nelson, JS

2000-01-01

Optical coherence tomography (OCT) was used to image the internal structure of a rat cochlea (ex vivo). Immediately following sacrifice, the temporal bone of a Sprague-Dawley rat was harvested. Axial OCT cross sectional images lover regions of interest, 1x1 mm-2x8 mm) were obtained with a spatial

Intermodulation and harmonic distortion in slow light Microwave Photonic phase shifters based on Coherent Population Oscillations in SOAs.

Science.gov (United States)

Gasulla, Ivana; Sancho, Juan; Capmany, José; Lloret, Juan; Sales, Salvador

2010-12-06

We theoretically and experimentally evaluate the propagation, generation and amplification of signal, harmonic and intermodulation distortion terms inside a Semiconductor Optical Amplifier (SOA) under Coherent Population Oscillation (CPO) regime. For that purpose, we present a general optical field model, valid for any arbitrarily-spaced radiofrequency tones, which is necessary to correctly describe the operation of CPO based slow light Microwave Photonic phase shifters which comprise an electrooptic modulator and a SOA followed by an optical filter and supplements another recently published for true time delay operation based on the propagation of optical intensities. The phase shifter performance has been evaluated in terms of the nonlinear distortion up to 3rd order, for a modulating signal constituted of two tones, in function of the electrooptic modulator input RF power and the SOA input optical power, obtaining a very good agreement between theoretical and experimental results. A complete theoretical spectral analysis is also presented which shows that under small signal operation conditions, the 3rd order intermodulation products at 2Ω1 + Ω2 and 2Ω2 + Ω1 experience a power dip/phase transition characteristic of the fundamental tones phase shifting operation.

Coherence properties and quantum state transportation in an optical conveyor belt.

Science.gov (United States)

Kuhr, S; Alt, W; Schrader, D; Dotsenko, I; Miroshnychenko, Y; Rosenfeld, W; Khudaverdyan, M; Gomer, V; Rauschenbeutel, A; Meschede, D

2003-11-21

We have prepared and detected quantum coherences of trapped cesium atoms with long dephasing times. Controlled transport by an "optical conveyor belt" over macroscopic distances preserves the atomic coherence with slight reduction of coherence time. The limiting dephasing effects are experimentally identified, and we present an analytical model of the reversible and irreversible dephasing mechanisms. Our experimental methods are applicable at the single-atom level. Coherent quantum bit operations along with quantum state transport open the route towards a "quantum shift register" of individual neutral atoms.

Phase coherence and Rabi frequency induced ultranarrow spectral line

International Nuclear Information System (INIS)

Dutta, Bibhas Kumar; Panchadhyayee, Pradipta; Mahapatra, Prasanta Kumar

2012-01-01

A scheme is proposed to achieve ultranarrow spectral line in the fluorescence spectrum of a lifetime broadened multilevel phase-coherent atom. It is shown that for weak-field coupling, ultranarrow spectral feature in the fluorescence spectrum can be generated by controlling the values of the Rabi frequencies involved in the coherent mechanism of the system. For fixed values of the Rabi frequencies in the weak-field limit, ultranarrow feature appears in the spectrum through the adjustment of the relative phase of the coherent fields. The results highlight that, larger the values of the decay rates associated with the field-driven channels, more pronounced is the phenomenon of narrowing in the spectrum.

Combatting nonlinear phase noise in coherent optical systems with an optimized decision processor based on machine learning

Science.gov (United States)

Wang, Danshi; Zhang, Min; Cai, Zhongle; Cui, Yue; Li, Ze; Han, Huanhuan; Fu, Meixia; Luo, Bin

2016-06-01

An effective machine learning algorithm, the support vector machine (SVM), is presented in the context of a coherent optical transmission system. As a classifier, the SVM can create nonlinear decision boundaries to mitigate the distortions caused by nonlinear phase noise (NLPN). Without any prior information or heuristic assumptions, the SVM can learn and capture the link properties from only a few training data. Compared with the maximum likelihood estimation (MLE) algorithm, a lower bit-error rate (BER) is achieved by the SVM for a given launch power; moreover, the launch power dynamic range (LPDR) is increased by 3.3 dBm for 8 phase-shift keying (8 PSK), 1.2 dBm for QPSK, and 0.3 dBm for BPSK. The maximum transmission distance corresponding to a BER of 1 ×10-3 is increased by 480 km for the case of 8 PSK. The larger launch power range and longer transmission distance improve the tolerance to amplitude and phase noise, which demonstrates the feasibility of the SVM in digital signal processing for M-PSK formats. Meanwhile, in order to apply the SVM method to 16 quadratic amplitude modulation (16 QAM) detection, we propose a parameter optimization scheme. By utilizing a cross-validation and grid-search techniques, the optimal parameters of SVM can be selected, thus leading to the LPDR improvement by 2.8 dBm. Additionally, we demonstrate that the SVM is also effective in combating the laser phase noise combined with the inphase and quadrature (I/Q) modulator imperfections, but the improvement is insignificant for the linear noise and separate I/Q imbalance. The computational complexity of SVM is also discussed. The relatively low complexity makes it possible for SVM to implement the real-time processing.

Wave packet interferometry and quantum state reconstruction by acousto-optic phase modulation

International Nuclear Information System (INIS)

Tekavec, Patrick F.; Dyke, Thomas R.; Marcus, Andrew H.

2006-01-01

Studies of wave packet dynamics often involve phase-selective measurements of coherent optical signals generated from sequences of ultrashort laser pulses. In wave packet interferometry (WPI), the separation between the temporal envelopes of the pulses must be precisely monitored or maintained. Here we introduce a new (and easy to implement) experimental scheme for phase-selective measurements that combines acousto-optic phase modulation with ultrashort laser excitation to produce an intensity-modulated fluorescence signal. Synchronous detection, with respect to an appropriately constructed reference, allows the signal to be simultaneously measured at two phases differing by 90 deg. Our method effectively decouples the relative temporal phase from the pulse envelopes of a collinear train of optical pulse pairs. We thus achieve a robust and high signal-to-noise scheme for WPI applications, such as quantum state reconstruction and electronic spectroscopy. The validity of the method is demonstrated, and state reconstruction is performed, on a model quantum system - atomic Rb vapor. Moreover, we show that our measurements recover the correct separation between the absorptive and dispersive contributions to the system susceptibility

Dual-comb spectroscopy of molecular electronic transitions in condensed phases

Science.gov (United States)

Cho, Byungmoon; Yoon, Tai Hyun; Cho, Minhaeng

2018-03-01

Dual-comb spectroscopy (DCS) utilizes two phase-locked optical frequency combs to allow scanless acquisition of spectra using only a single point detector. Although recent DCS measurements demonstrate rapid acquisition of absolutely calibrated spectral lines with unprecedented precision and accuracy, complex phase-locking schemes and multiple coherent averaging present significant challenges for widespread adoption of DCS. Here, we demonstrate Global Positioning System (GPS) disciplined DCS of a molecular electronic transition in solution at around 800 nm, where the absorption spectrum is recovered by using a single time-domain interferogram. We anticipate that this simplified dual-comb technique with absolute time interval measurement and ultrabroad bandwidth will allow adoption of DCS to tackle molecular dynamics investigation through its implementation in time-resolved nonlinear spectroscopic studies and coherent multidimensional spectroscopy of coupled chromophore systems.

Simple and versatile long range swept source for optical coherence tomography applications

International Nuclear Information System (INIS)

Bräuer, Bastian; Lippok, Norman; Murdoch, Stuart G; Vanholsbeeck, Frédérique

2015-01-01

We present a versatile long coherence length swept-source laser design for optical coherence tomography applications. This design consists of a polygonal spinning mirror and an optical gain chip in a modified Littman–Metcalf cavity. A narrowband intra-cavity filter is implemented through multiple passes off a diffraction grating set at grazing incidence. The key advantage of this design is that it can be readily adapted to any wavelength regions for which broadband gain chips are available. We demonstrate this by implementing sources at 1650 nm, 1550 nm, 1310 nm and 1050 nm. In particular, we present a 1310 nm swept source laser with 24 mm coherence length, 95 nm optical bandwidth, 2 kHz maximum sweep frequency and 7.5 mW average output power. These parameters make it a suitable source for the imaging of biological samples. (paper)

Effects of absorption on coherence domain path length resolved dynamic light scattering in the diffuse regime

NARCIS (Netherlands)

Petoukhova, A. L.; Steenbergen, W.; van Leeuwen, T. G.; de Mul, F. F. M.

2002-01-01

A low coherence Mach-Zehnder interferometer is developed for path length resolved dynamic light scattering in highly turbid media. The path length distribution of multiply scattered photons in Intralipid is changed by the addition of absorbing dyes. Path length distributions obtained for various

Effects of absorption on coherence domain path length resolved dynamic light scattering in the diffuse regime

NARCIS (Netherlands)

Petoukhova, Anna; Steenbergen, Wiendelt; van Leeuwen, Ton; de Mul, F.F.M.

2002-01-01

A low coherence Mach–Zehnder interferometer is developed for path length resolved dynamic light scattering in highly turbid media. The path length distribution of multiply scatteredphotons in Intralipid is changed by the addition of absorbing dyes. Path length distributions obtained for various

Performance improvement of 64-QAM coherent optical communication system by optimizing symbol decision boundary based on support vector machine

Science.gov (United States)

Chen, Wei; Zhang, Junfeng; Gao, Mingyi; Shen, Gangxiang

2018-03-01

High-order modulation signals are suited for high-capacity communication systems because of their high spectral efficiency, but they are more vulnerable to various impairments. For the signals that experience degradation, when symbol points overlap on the constellation diagram, the original linear decision boundary cannot be used to distinguish the classification of symbol. Therefore, it is advantageous to create an optimum symbol decision boundary for the degraded signals. In this work, we experimentally demonstrated the 64-quadrature-amplitude modulation (64-QAM) coherent optical communication system using support-vector machine (SVM) decision boundary algorithm to create the optimum symbol decision boundary for improving the system performance. We investigated the influence of various impairments on the 64-QAM coherent optical communication systems, such as the impairments caused by modulator nonlinearity, phase skew between in-phase (I) arm and quadrature-phase (Q) arm of the modulator, fiber Kerr nonlinearity and amplified spontaneous emission (ASE) noise. We measured the bit-error-ratio (BER) performance of 75-Gb/s 64-QAM signals in the back-to-back and 50-km transmission. By using SVM to optimize symbol decision boundary, the impairments caused by I/Q phase skew of the modulator, fiber Kerr nonlinearity and ASE noise are greatly mitigated.

Improvements in brain activation detection using time-resolved diffuse optical means

Science.gov (United States)

Montcel, Bruno; Chabrier, Renee; Poulet, Patrick

2005-08-01

An experimental method based on time-resolved absorbance difference is described. The absorbance difference is calculated over each temporal step of the optical signal with the time-resolved Beer-Lambert law. Finite element simulations show that each step corresponds to a different scanned zone and that cerebral contribution increases with the arrival time of photons. Experiments are conducted at 690 and 830 nm with a time-resolved system consisting of picosecond laser diodes, micro-channel plate photo-multiplier tube and photon counting modules. The hemodynamic response to a short finger tapping stimulus is measured over the motor cortex. Time-resolved absorbance difference maps show that variations in the optical signals are not localized in superficial regions of the head, which testify for their cerebral origin. Furthermore improvements in the detection of cerebral activation is achieved through the increase of variations in absorbance by a factor of almost 5 for time-resolved measurements as compared to non-time-resolved measurements.

Functional optical coherence tomography: principles and progress

International Nuclear Information System (INIS)

Kim, Jina; Levinson, Howard; Brown, William; Maher, Jason R.; Wax, Adam

2015-01-01

In the past decade, several functional extensions of optical coherence tomography (OCT) have emerged, and this review highlights key advances in instrumentation, theoretical analysis, signal processing and clinical application of these extensions. We review five principal extensions: Doppler OCT (DOCT), polarization-sensitive OCT (PS-OCT), optical coherence elastography (OCE), spectroscopic OCT (SOCT), and molecular imaging OCT. The former three have been further developed with studies in both ex vivo and in vivo human tissues. This review emphasizes the newer techniques of SOCT and molecular imaging OCT, which show excellent potential for clinical application but have yet to be well reviewed in the literature. SOCT elucidates tissue characteristics, such as oxygenation and carcinogenesis, by detecting wavelength-dependent absorption and scattering of light in tissues. While SOCT measures endogenous biochemical distributions, molecular imaging OCT detects exogenous molecular contrast agents. These newer advances in functional OCT broaden the potential clinical application of OCT by providing novel ways to understand tissue activity that cannot be accomplished by other current imaging methodologies. (topical review)

Determination of Optical-Field Ionization Dynamics in Plasmas through the Direct Measurement of the Optical Phase Change

International Nuclear Information System (INIS)

Taylor, A.J.; Omenetto, G.; Rodriguez, G.; Siders, C.W.; Siders, J.L.W.; Downer, C.

1999-01-01

This is the final report of a three-year Laboratory Directed Research and Development (LDRD) Project at Los Alamos National Laboratory (LANL). The detailed dynamics of an atom in a strong laser field is rich in both interesting physics and potential applications. The goal of this project was to develop a technique for characterizing high-field laser-plasma interactions with femtosecond resolution based on the direct measurement of the phase change of an optical pulse. The authors developed the technique of Multi-pulse Interferometric Frequency Resolved Optical Gating (MI-FROG), which recovers (to all orders) the phase difference between pumped and unpumped probe pulses, enabling the determination of sub-pulsewidth time-resolved phase and frequency shifts impressed by a pump pulse on a weak probe pulse. Using MI-FROG, the authors obtained the first quantitative measurements of high-field ionization rates in noble gases and diatomic molecules. They obtained agreement between the measured ionization rates an d those calculated for the noble gases and diatomic nitrogen and hydrogen using a one-dimensional fluid model and rates derived from tunneling theory. However, much higher rates are measured for diatomic oxygen than predicted by tunneling theory calculations

Common-path low-coherence interferometry fiber-optic sensor guided microincision

Science.gov (United States)

Zhang, Kang; Kang, Jin U.

2011-09-01

We propose and demonstrate a common-path low-coherence interferometry (CP-LCI) fiber-optic sensor guided precise microincision. The method tracks the target surface and compensates the tool-to-surface relative motion with better than +/-5 μm resolution using a precision micromotor connected to the tool tip. A single-fiber distance probe integrated microdissector was used to perform an accurate 100 μm incision into the surface of an Intralipid phantom. The CP-LCI guided incision quality in terms of depth was evaluated afterwards using three-dimensional Fourier-domain optical coherence tomography imaging, which showed significant improvement of incision accuracy compared to free-hand-only operations.

Novel adaptive fiber-optics collimator for coherent beam combination.

Science.gov (United States)

Zhi, Dong; Ma, Pengfei; Ma, Yanxing; Wang, Xiaolin; Zhou, Pu; Si, Lei

2014-12-15

In this manuscript, we experimentally validate a novel design of adaptive fiber-optics collimator (AFOC), which utilizes two levers to enlarge the movable range of the fiber end cap. The enlargement of the range makes the new AFOC possible to compensate the end-cap/tilt aberration in fiber laser beam combining system. The new AFOC based on flexible hinges and levers was fabricated and the performance of the new AFOC was tested carefully, including its control range, frequency response and control accuracy. Coherent beam combination (CBC) of two 5-W fiber amplifiers array with simultaneously end-cap/tilt control and phase-locking control was implemented successfully with the novel AFOC. Experimental results show that the average normalized power in the bucket (PIB) value increases from 0.311 to 0.934 with active phasing and tilt aberration compensation simultaneously, and with both controls on, the fringe contrast improves to more than 82% from 0% for the case with both control off. This work presents a promising structure for tilt aberration control in high power CBC system.

Adaptive optics scanning laser ophthalmoscopy in combination with en-face optical coherence tomography

International Nuclear Information System (INIS)

Felberer, F.

2014-01-01

The human retina is a most important tissue and plays a fundamental role for the vision. Diseases of the eye affect the normal retinal function which, if untreated, may lead to vision loss or ultimately to blindness. Thus, in vivo diagnostic tools that provide detailed information on the retinal status are required in order to improve diagnosis and treatment. In recent years, several new optical imaging methods of the human retina have been developed and now represent the key part in a standard ophthalmic examination process. One of these technologies is optical coherence tomography (OCT), which provides images of the retina noninvasively and with a high axial resolution. However, imperfections of the eye's optics cause aberrations of the wavefront of the imaging light, thus limiting the transverse resolution of such systems. Improvements in the resolution of retinal images are necessary to resolve individual cells (e.g. photoreceptors) which may provide new opportunities in retinal diagnostics and therapy control. Adaptive optics (AO), a technology known from astronomy, may be used to increase image resolution. Aberrations of the imaging light are measured and corrected, resulting in an increase of lateral resolution up to the diffraction limit. Within this thesis, AO was combined with a scanning laser ophthalmoscope (SLO) that enables high resolution imaging of the retina. Measurements on healthy subjects demonstrated the ability of the system to resolve foveal cones (the smallest cone photoreceptors within the retina) and even rod photoreceptors. However, the depth resolution of the system remained limited compared to OCT instruments. Thus, in a second step, the instrument was extended to a combined AO-SLO/OCT system. The OCT system is based on transversal scanning (TS)-OCT which records en-face images of the retina and incorporates a high-speed axial eye tracking device. Together with transverse motion correction based on the AO-SLO images, the system

Optical coherence tomography for the diagnosis of human otitis media

Science.gov (United States)

Cho, Nam Hyun; Jung, Unsang; Jang, Jeong Hun; Jung, Woonggyu; Kim, Jeehyun; Lee, Sang Heun; Boppart, Stephen A.

2013-05-01

We report the application of Optical Coherence Tomography (OCT) to various types of human cases of otitis media (OM). Whereas conventional diagnostic modalities for OM, including standard and pneumatic otoscopy, are limited to visualizing the surface information of the tympanic membrane (TM), OCT is able to effectively reveal the depth-resolved microstructural below the TM with a very high spatial resolution. With the potential advantage of using OCT for diagnosing different types of OM, we examined in-vivo the use of 840 nm wavelength, and OCT spectral domain OCT (SDOCT) techniques, in several human cases including normal ears, and ears with adhesive and effusion types of OM. Peculiar positions were identified in two-dimensional OCT images of abnormal TMs compared to images of a normal TM. Analysis of A-scan (axial depth-scans) data from these positions could successfully identify unique patterns for different constituents within effusions. These OCT images may not only be used for constructing a database for the diagnosis and classification of OM, but they may also demonstrate the feasibility and advantages for upgrading the current otoscopy techniques.

Sub-nanosecond time-resolved near-field scanning magneto-optical microscope.

Science.gov (United States)

Rudge, J; Xu, H; Kolthammer, J; Hong, Y K; Choi, B C

2015-02-01

We report on the development of a new magnetic microscope, time-resolved near-field scanning magneto-optical microscope, which combines a near-field scanning optical microscope and magneto-optical contrast. By taking advantage of the high temporal resolution of time-resolved Kerr microscope and the sub-wavelength spatial resolution of a near-field microscope, we achieved a temporal resolution of ∼50 ps and a spatial resolution of microscope, the magnetic field pulse induced gyrotropic vortex dynamics occurring in 1 μm diameter, 20 nm thick CoFeB circular disks has been investigated. The microscope provides sub-wavelength resolution magnetic images of the gyrotropic motion of the vortex core at a resonance frequency of ∼240 MHz.

Integrated coherent matter wave circuits

International Nuclear Information System (INIS)

Ryu, C.; Boshier, M. G.

2015-01-01

An integrated coherent matter wave circuit is a single device, analogous to an integrated optical circuit, in which coherent de Broglie waves are created and then launched into waveguides where they can be switched, divided, recombined, and detected as they propagate. Applications of such circuits include guided atom interferometers, atomtronic circuits, and precisely controlled delivery of atoms. We report experiments demonstrating integrated circuits for guided coherent matter waves. The circuit elements are created with the painted potential technique, a form of time-averaged optical dipole potential in which a rapidly moving, tightly focused laser beam exerts forces on atoms through their electric polarizability. Moreover, the source of coherent matter waves is a Bose-Einstein condensate (BEC). Finally, we launch BECs into painted waveguides that guide them around bends and form switches, phase coherent beamsplitters, and closed circuits. These are the basic elements that are needed to engineer arbitrarily complex matter wave circuitry

Application of Soft Computing in Coherent Communications Phase Synchronization

Science.gov (United States)

Drake, Jeffrey T.; Prasad, Nadipuram R.

2000-01-01

The use of soft computing techniques in coherent communications phase synchronization provides an alternative to analytical or hard computing methods. This paper discusses a novel use of Adaptive Neuro-Fuzzy Inference Systems (ANFIS) for phase synchronization in coherent communications systems utilizing Multiple Phase Shift Keying (MPSK) modulation. A brief overview of the M-PSK digital communications bandpass modulation technique is presented and it's requisite need for phase synchronization is discussed. We briefly describe the hybrid platform developed by Jang that incorporates fuzzy/neural structures namely the, Adaptive Neuro-Fuzzy Interference Systems (ANFIS). We then discuss application of ANFIS to phase estimation for M-PSK. The modeling of both explicit, and implicit phase estimation schemes for M-PSK symbols with unknown structure are discussed. Performance results from simulation of the above scheme is presented.

Online monitoring of printed electronics by Spectral-Domain Optical Coherence Tomography

KAUST Repository

Alarousu, Erkki; Alsaggaf, Ahmed; Jabbour, Ghassan E.

2013-01-01

Spectral-Domain Optical Coherence Tomography (SD-OCT) is an optical method capable of 3D imaging of object's internal structure with micron-scale resolution. Modern SD-OCT tools offer the speed capable of online monitoring of printed devices

Research progress of free space coherent optical communication

Science.gov (United States)

Tan, Zhenkun; Ke, Xizheng

2018-02-01

This paper mainly introduces the research progress of free space coherent optical communication in Xi'an University of Technology. In recent years, the research on the outer modulation technology of the laser, free-space-to-fiber coupling technique, the design of transmitting and receiving optical antenna, adaptive optical technology with or without wave-front sensor, automatic polarization control technology, frequency stabilization technology, heterodyne detection technology and high speed signal processing technology. Based on the above related research, the digital signal modulation, transmission, detection and data recovery are realized by the heterodyne detection technology in the free space optical communication system, and finally the function of smooth viewing high-definition video is realized.

Temperature Measurements in Reacting Flows Using Time-Resolved Femtosecond Coherent Anti-Stokes Raman Scattering (fs-CARS) Spectroscopy (Postprint)

National Research Council Canada - National Science Library

Roy, Sukesh; Kinnius, Paul J; Lucht, Robert P; Gord, James R

2007-01-01

Time-resolved femtosecond coherent anti-Stokes Raman scattering (fs-CARS) spectroscopy of the nitrogen molecule is used for the measurement of temperature in atmospheric-pressure, near-adiabatic, hydrogen-air diffusion flames...

Quantitative assessment of hyaline cartilage elasticity during optical clearing using optical coherence elastography

Science.gov (United States)

Liu, Chih-Hao; Singh, Manmohan; Li, Jiasong; Han, Zhaolong; Wu, Chen; Wang, Shang; Idugboe, Rita; Raghunathan, Raksha; Zakharov, Valery P.; Sobol, Emil N.; Tuchin, Valery V.; Twa, Michael; Larin, Kirill V.

2015-03-01

We report the first study on using optical coherence elastography (OCE) to quantitatively monitor the elasticity change of the hyaline cartilage during the optical clearing administrated by glucose solution. The measurement of the elasticity is verified using uniaxial compression test, demonstrating the feasibility of using OCE to quantify the Young's modulus of the cartilage tissue. As the results, we found that the stiffness of the hyaline cartilage increases during the optical clearing of the tissue. This study might be potentially useful for the early detection of osteoarthritis disease.

Analysis of parallel optical sampling rate and ADC requirements in digital coherent receivers

DEFF Research Database (Denmark)

Lorences Riesgo, Abel; Galili, Michael; Peucheret, Christophe

2012-01-01

We comprehensively assess analog-to-digital converter requirements in coherent digital receiver schemes with parallel optical sampling. We determine the electronic requirements in accordance with the properties of the free running local oscillator.......We comprehensively assess analog-to-digital converter requirements in coherent digital receiver schemes with parallel optical sampling. We determine the electronic requirements in accordance with the properties of the free running local oscillator....

Engineering of Nanoscale Contrast Agents for Optical Coherence Tomography.

Science.gov (United States)

Gordon, Andrew Y; Jayagopal, Ashwath

2014-01-30

Optical coherence tomography has emerged as valuable imaging modalityin ophthalmology and other fields by enabling high-resolution three-dimensional imaging of tissue. In this paper, we review recent progress in the field of contrast-enhanced optical coherence tomography (OCT). We discuss exogenous and endogenous sources of OCT contrast, focusing on their use with standard OCT systems as well as emerging OCT-based imaging modalities. We include advances in the processing of OCT data that generate improved tissue contrast, including spectroscopic OCT (SOCT), as well as work utilizing secondary light sources and/or detection mechanisms to create and detect enhanced contrast, including photothermal OCT (PTOCT) and photoacoustic OCT (PAOCT). Finally, we conclude with a discussion of the translational potential of these developments as well as barriers to their clinical use.

Perfect-crystal x-ray optics to treat x-ray coherence

International Nuclear Information System (INIS)

Yamazaki, Hiroshi; Ishikawa, Tetsuya

2007-01-01

X-ray diffraction of perfect crystals, which serve as x-ray monochromator and collimator, modifies coherence properties of x-ray beams. From the time-dependent Takagi-Taupin equations that x-ray wavefields obey in crystals, the reflected wavefield is formulated as an integral transform of a general incident wavefield with temporal and spatial inhomogeneity. A reformulation of rocking-curve profiles from the field solution of the Takagi-Taupin equations allows experimental evaluation of the mutual coherence function of x-ray beam. The rigorous relationship of the coherence functions between before and after reflection clarifies how the coherence is transferred by a crystal. These results will be beneficial to developers of beamline optics for the next generation synchrotron sources. (author)

Spectral coherent-state quantum cryptography.

Science.gov (United States)

Cincotti, Gabriella; Spiekman, Leo; Wada, Naoya; Kitayama, Ken-ichi

2008-11-01

A novel implementation of quantum-noise optical cryptography is proposed, which is based on a simplified architecture that allows long-haul, high-speed transmission in a fiber optical network. By using a single multiport encoder/decoder and 16 phase shifters, this new approach can provide the same confidentiality as other implementations of Yuen's encryption protocol, which use a larger number of phase or polarization coherent states. Data confidentiality and error probability for authorized and unauthorized receivers are carefully analyzed.

Analysis of detection limit to time-resolved coherent anti-Stokes Raman scattering nanoscopy

International Nuclear Information System (INIS)

Liu Wei; Liu Shuang-Long; Chen Dan-Ni; Niu Han-Ben

2014-01-01

In the implementation of CARS nanoscopy, signal strength decreases with focal volume size decreasing. A crucial problem that remains to be solved is whether the reduced signal generated in the suppressed focal volume can be detected. Here reported is a theoretical analysis of detection limit (DL) to time-resolved CARS (T-CARS) nanoscopy based on our proposed additional probe-beam-induced phonon depletion (APIPD) method for the low concentration samples. In order to acquire a detailed shot-noise limited signal-to-noise (SNR) and the involved parameters to evaluate DL, the T-CARS process is described with full quantum theory to estimate the extreme power density levels of the pump and Stokes beams determined by saturation behavior of coherent phonons, which are both actually on the order of ∼ 10 9 W/cm 2 . When the pump and Stokes intensities reach such values and the total intensity of the excitation beams arrives at a maximum tolerable by most biological samples in a certain suppressed focal volume (40-nm suppressed focal scale in APIPD method), the DL correspondingly varies with exposure time, for example, DL values are 10 3 and 10 2 when exposure times are 20 ms and 200 ms respectively. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using phase sensitive Fourier domain optical coherence tomography

Science.gov (United States)

Ramamoorthy, Sripriya; Zhang, Yuan; Petrie, Tracy; Fridberger, Anders; Ren, Tianying; Wang, Ruikang; Jacques, Steven L.; Nuttall, Alfred L.

2015-02-01

In this study, we measure the in vivo apical-turn vibrations of the guinea pig organ of Corti in both axial and radial directions using phase-sensitive Fourier domain optical coherence tomography. The apical turn in guinea pig cochlea has best frequencies around 100 - 500 Hz which are relevant for human speech. Prior measurements of vibrations in the guinea pig apex involved opening the otic capsule, which has been questioned on the basis of the resulting changes to cochlear hydrodynamics. Here this limitation is overcome by measuring the vibrations through bone without opening the otic capsule. Furthermore, we have significantly reduced the surgery needed to access the guinea pig apex in the axial direction by introducing a miniature mirror inside the bulla. The method and preliminary data are discussed in this article.

Spectral-domain optical coherence tomography of roth spots.

Science.gov (United States)

Giovinazzo, Jerome; Mrejen, Sarah; Freund, K Bailey

2013-01-01

To describe the retinal findings of subacute bacterial endocarditis, their evolution after treatment, and analysis with spectral-domain optical coherence tomography. Retrospective chart review. A 21-year-old man presented with the sudden onset of a central scotoma in his left eye because of a sub-internal limiting membrane hemorrhage overlying the left fovea. When examined 2 weeks later, Roth spots were noted in his right eye. The patient was immediately referred to his internist and diagnosed with subacute bacterial endocarditis with cultures positive for Streptococcus viridans. He subsequently underwent aortic valve replacement surgery after 4 weeks of intravenous antibiotic therapy. When examined 4 weeks after valve replacement surgery, there was regression of the Roth spots. The present case demonstrates the importance of a funduscopic examination in the early diagnosis and management of subacute bacterial endocarditis. The analysis of Roth spots with spectral-domain optical coherence tomography suggested that they were septic emboli.

State-Resolved Metal Nanoparticle Dynamics Viewed through the Combined Lenses of Ultrafast and Magneto-optical Spectroscopies.

Science.gov (United States)

Zhao, Tian; Herbert, Patrick J; Zheng, Hongjun; Knappenberger, Kenneth L

2018-05-08

Electronic carrier dynamics play pivotal roles in the functional properties of nanomaterials. For colloidal metals, the mechanisms and influences of these dynamics are structure dependent. The coherent carrier dynamics of collective plasmon modes for nanoparticles (approximately 2 nm and larger) determine optical amplification factors that are important to applied spectroscopy techniques. In the nanocluster domain (sub-2 nm), carrier coupling to vibrational modes affects photoluminescence yields. The performance of photocatalytic materials featuring both nanoparticles and nanoclusters also depends on the relaxation dynamics of nonequilibrium charge carriers. The challenges for developing comprehensive descriptions of carrier dynamics spanning both domains are multifold. Plasmon coherences are short-lived, persisting for only tens of femtoseconds. Nanoclusters exhibit discrete carrier dynamics that can persist for microseconds in some cases. On this time scale, many state-dependent processes, including vibrational relaxation, charge transfer, and spin conversion, affect carrier dynamics in ways that are nonscalable but, rather, structure specific. Hence, state-resolved spectroscopy methods are needed for understanding carrier dynamics in the nanocluster domain. Based on these considerations, a detailed understanding of structure-dependent carrier dynamics across length scales requires an appropriate combination of spectroscopic methods. Plasmon mode-specific dynamics can be obtained through ultrafast correlated light and electron microscopy (UCLEM), which pairs interferometric nonlinear optical (INLO) with electron imaging methods. INLO yields nanostructure spectral resonance responses, which capture the system's homogeneous line width and coherence dynamics. State-resolved nanocluster dynamics can be obtained by pairing ultrafast with magnetic-optical spectroscopy methods. In particular, variable-temperature variable-field (VTVH) spectroscopies allow quantification

Optical computing.

Science.gov (United States)

Stroke, G. W.

1972-01-01

Applications of the optical computer include an approach for increasing the sharpness of images obtained from the most powerful electron microscopes and fingerprint/credit card identification. The information-handling capability of the various optical computing processes is very great. Modern synthetic-aperture radars scan upward of 100,000 resolvable elements per second. Fields which have assumed major importance on the basis of optical computing principles are optical image deblurring, coherent side-looking synthetic-aperture radar, and correlative pattern recognition. Some examples of the most dramatic image deblurring results are shown.

Optical coherence refractometry.

Science.gov (United States)

Tomlins, Peter H; Woolliams, Peter; Hart, Christian; Beaumont, Andrew; Tedaldi, Matthew

2008-10-01

We introduce a novel approach to refractometry using a low coherence interferometer at multiple angles of incidence. We show that for plane parallel samples it is possible to measure their phase refractive index rather than the group index that is usually measured by interferometric methods. This is a significant development because it enables bulk refractive index measurement of scattering and soft samples, not relying on surface measurements that can be prone to error. Our technique is also noncontact and compatible with in situ refractive index measurements. Here, we demonstrate this new technique on a pure silica test piece and a highly scattering resin slab, comparing the results with standard critical angle refractometry.

Observation of long phase-coherence length in epitaxial La-doped CdO thin films

Science.gov (United States)

Yun, Yu; Ma, Yang; Tao, Songsheng; Xing, Wenyu; Chen, Yangyang; Su, Tang; Yuan, Wei; Wei, Jian; Lin, Xi; Niu, Qian; Xie, X. C.; Han, Wei

2017-12-01

The search for long electron phase-coherence length, which is the length that an electron can keep its quantum wavelike properties, has attracted considerable interest in the last several decades. Here, we report the long phase-coherence length of ˜3.7 μm in La-doped CdO thin films at 2 K. Systematical investigations of the La doping and the temperature dependences of the electron mobility and the electron phase-coherence length reveal contrasting scattering mechanisms for these two physical properties. Furthermore, these results show that the oxygen vacancies could be the dominant scatters in CdO thin films that break the electron phase coherence, which would shed light on further investigation of phase-coherence properties in oxide materials.

Hilbert and Blaschke phases in the temporal coherence function of stationary broadband light.

Science.gov (United States)

Fernández-Pousa, Carlos R; Maestre, Haroldo; Torregrosa, Adrián J; Capmany, Juan

2008-10-27

We show that the minimal phase of the temporal coherence function gamma (tau) of stationary light having a partially-coherent symmetric spectral peak can be computed as a relative logarithmic Hilbert transform of its amplitude with respect to its asymptotic behavior. The procedure is applied to experimental data from amplified spontaneous emission broadband sources in the 1.55 microm band with subpicosecond coherence times, providing examples of degrees of coherence with both minimal and non-minimal phase. In the latter case, the Blaschke phase is retrieved and the position of the Blaschke zeros determined.

Imaging vibration of the cochlear partition of an excised guinea pig cochlea using phase-sensitive Fourier domain optical coherence tomography

Science.gov (United States)

Choudhury, Niloy; Zeng, Yaguang; Fridberger, Anders; Chen, Fangyi; Zha, Dingjun; Nuttall, Alfred L.; Wang, Ruikang K.

2011-03-01

Studying the sound stimulated vibrations of various membranes that form the complex structure of the organ of Corti in the cochlea of the inner ear is essential for understanding how the travelling sound wave of the basilar membrane couples its energy to the organ structures. In this paper we report the feasibility of using phase-sensitive Fourier domain optical coherence tomography (FD-OCT) to image the vibration of various micro-structures of the cochlea at the same time. An excised cochlea of a guinea pig was stimulated using sounds at various frequencies and vibration image was obtained. When measuring the apex area, vibration signal from different turns, which have different best response frequencies are obtained in the same image. The method has the potential to measure the response from a much wider region of the cochlea than any other currently used method. The noise floor for vibration image for the system at 200 Hz was ~0.3nm.

Transverse phase space mapping of relativistic electron beams using optical transition radiation

Directory of Open Access Journals (Sweden)

G. P. Le Sage

1999-12-01

Full Text Available Optical transition radiation (OTR has proven to be a versatile and effective diagnostic for measuring the profile, divergence, and emittance of relativistic electron beams with a wide range of parameters. Diagnosis of the divergence of modern high brightness beams is especially well suited to OTR interference (OTRI techniques, where multiple dielectric or metal foils are used to generate a spatially coherent interference pattern. Theoretical analysis of measured OTR and OTRI patterns allows precise measurement of electron beam emittance characteristics. Here we describe an extension of this technique to allow mapping of divergence characteristics as a function of transverse coordinates within a measured beam. We present the first experimental analysis of the transverse phase space of an electron beam using all optical techniques. Comparing an optically masked portion of the beam to the entire beam, we measure different angular spread and average direction of the particles. Direct measurement of the phase-space ellipse tilt angle has been demonstrated using this optical masking technique.

In-situ biofouling assessment in spacer filled channels using optical coherence tomography (OCT): 3D biofilm thickness mapping

KAUST Repository

Fortunato, Luca

2017-01-13

Membrane systems for water purification can be seriously hampered by biofouling. The use of optical coherence tomography (OCT) to investigate biofilms in membrane systems has recently increased due to the ability to do the characterization in-situ and non-destructively The OCT biofilm thickness map is presented for the first time as a tool to assess biofilm spatial distribution on a surface. The map allows the visualization and evaluation of the biofilm formation and growth in membrane filtration systems through the use of a false color scale. The biofilm development was monitored with OCT to evaluate the suitability of the proposed approach. A 3D time series analysis of biofilm development in a spacer filled channel representative of a spiral-wound membrane element was performed. The biofilm thickness map enables the time-resolved and spatial-resolved evaluation and visualization of the biofilm deposition pattern in-situ non-destructively.

CAPILLARY NETWORK ANOMALIES IN BRANCH RETINAL VEIN OCCLUSION ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.

Science.gov (United States)

Rispoli, Marco; Savastano, Maria Cristina; Lumbroso, Bruno

2015-11-01

To analyze the foveal microvasculature features in eyes with branch retinal vein occlusion (BRVO) using optical coherence tomography angiography based on split spectrum amplitude decorrelation angiography technology. A total of 10 BRVO eyes (mean age 64.2 ± 8.02 range between 52 years and 76 years) were evaluated by optical coherence tomography angiography (XR-Avanti; Optovue). The macular angiography scan protocol covered a 3 mm × 3 mm area. The focus of angiography analysis were two retinal layers: superficial vascular network and deep vascular network. The following vascular morphological congestion parameters were assessed in the vein occlusion area in both the superficial and deep networks: foveal avascular zone enlargement, capillary non-perfusion occurrence, microvascular abnormalities appearance, and vascular congestion signs. Image analyses were performed by 2 masked observers and interobserver agreement of image analyses was 0.90 (κ = 0.225, P network of BRVO, a decrease in capillary density with foveal avascular zone enlargement, capillary non-perfusion occurrence, and microvascular abnormalities appearance was observed (P network showed the main vascular congestion at the boundary between healthy and nonperfused retina. Optical coherence tomography angiography in BRVO allows to detect foveal avascular zone enlargement, capillary nonperfusion, microvascular abnormalities, and vascular congestion signs both in the superficial and deep capillary network in all eyes. Optical coherence tomography angiography technology is a potential clinical tool for BRVO diagnosis and follow-up, providing stratigraphic vascular details that have not been previously observed by standard fluorescein angiography. The normal retinal vascular nets and areas of nonperfusion and congestion can be identified at various retinal levels. Optical coherence tomography angiography provides noninvasive images of the retinal capillaries and vascular networks.

Optical coherence tomography in the diagnosis of actinic keratosis

DEFF Research Database (Denmark)

Friis, K B E; Themstrup, L; Jemec, G B E

2017-01-01

BACKGROUND: Optical coherence tomography (OCT) is a real-time non-invasive imaging tool, introduced in dermatology in the late 1990s. OCT uses near-infrared light impulses to produce images which can be displayed in cross-sectional and en-face mode. The technique has been used to image skin...... of layers consistent with absence of normal layered architecture in the skin. Thickened epidermis was found in 14/16 studies and white (hyperreflective) streaks and dots were described in 11/16 studies. In High-definition optical coherence tomography (HD-OCT) images disarranged epidermis (cross......-sectional images) along with an atypical honeycomb pattern (en-face images) was found in 5/5 studies and well-demarcated dermo-epithelial junction (DEJ) (cross-sectional images) was described in 3/5 studies. CONCLUSION: Several morphological characteristics of AKs were identified using Conventional OCT and HD...

Fast Industrial Inspection of Optical Thin Film Using Optical Coherence Tomography

Directory of Open Access Journals (Sweden)

Muhammad Faizan Shirazi

2016-09-01

Full Text Available An application of spectral domain optical coherence tomography (SD-OCT was demonstrated for a fast industrial inspection of an optical thin film panel. An optical thin film sample similar to a liquid crystal display (LCD panel was examined. Two identical SD-OCT systems were utilized for parallel scanning of a complete sample in half time. Dual OCT inspection heads were utilized for transverse (fast scanning, while a stable linear motorized translational stage was used for lateral (slow scanning. The cross-sectional and volumetric images of an optical thin film sample were acquired to detect the defects in glass and other layers that are difficult to observe using visual inspection methods. The rapid inspection enabled by this setup led to the early detection of product defects on the manufacturing line, resulting in a significant improvement in the quality assurance of industrial products.

Self-imaging in first-order optical systems

NARCIS (Netherlands)

Alieva, T.; Bastiaans, M.J.; Nijhawan, O.P.; Guota, A.K.; Musla, A.K.; Singh, Kehar

1998-01-01

The structure and main properties of coherent and partially coherent optical fields that are self-reproducible under propagation through a first-order optical system are investigated. A phase space description of self-imaging in first-order optical systems is presented. The Wigner distribution

An intelligent despeckling method for swept source optical coherence tomography images of skin

Science.gov (United States)

Adabi, Saba; Mohebbikarkhoran, Hamed; Mehregan, Darius; Conforto, Silvia; Nasiriavanaki, Mohammadreza

2017-03-01

Optical Coherence Optical coherence tomography is a powerful high-resolution imaging method with a broad biomedical application. Nonetheless, OCT images suffer from a multiplicative artefacts so-called speckle, a result of coherent imaging of system. Digital filters become ubiquitous means for speckle reduction. Addressing the fact that there still a room for despeckling in OCT, we proposed an intelligent speckle reduction framework based on OCT tissue morphological, textural and optical features that through a trained network selects the winner filter in which adaptively suppress the speckle noise while preserve structural information of OCT signal. These parameters are calculated for different steps of the procedure to be used in designed Artificial Neural Network decider that select the best denoising technique for each segment of the image. Results of training shows the dominant filter is BM3D from the last category.

Partially coherent X-ray wavefront propagation simulations including grazing-incidence focusing optics.

Science.gov (United States)

Canestrari, Niccolo; Chubar, Oleg; Reininger, Ruben

2014-09-01

X-ray beamlines in modern synchrotron radiation sources make extensive use of grazing-incidence reflective optics, in particular Kirkpatrick-Baez elliptical mirror systems. These systems can focus the incoming X-rays down to nanometer-scale spot sizes while maintaining relatively large acceptance apertures and high flux in the focused radiation spots. In low-emittance storage rings and in free-electron lasers such systems are used with partially or even nearly fully coherent X-ray beams and often target diffraction-limited resolution. Therefore, their accurate simulation and modeling has to be performed within the framework of wave optics. Here the implementation and benchmarking of a wave-optics method for the simulation of grazing-incidence mirrors based on the local stationary-phase approximation or, in other words, the local propagation of the radiation electric field along geometrical rays, is described. The proposed method is CPU-efficient and fully compatible with the numerical methods of Fourier optics. It has been implemented in the Synchrotron Radiation Workshop (SRW) computer code and extensively tested against the geometrical ray-tracing code SHADOW. The test simulations have been performed for cases without and with diffraction at mirror apertures, including cases where the grazing-incidence mirrors can be hardly approximated by ideal lenses. Good agreement between the SRW and SHADOW simulation results is observed in the cases without diffraction. The differences between the simulation results obtained by the two codes in diffraction-dominated cases for illumination with fully or partially coherent radiation are analyzed and interpreted. The application of the new method for the simulation of wavefront propagation through a high-resolution X-ray microspectroscopy beamline at the National Synchrotron Light Source II (Brookhaven National Laboratory, USA) is demonstrated.

PHASE-RESOLVED TIMING ANALYSIS OF GRS 1915+105 IN ITS ρ STATE

International Nuclear Information System (INIS)

Yan, Shu-Ping; Wang, Na; Ding, Guo-Qiang; Qu, Jin-Lu

2013-01-01

We made a phase-resolved timing analysis of GRS 1915+105 in its ρ state and obtained detailed ρ cycle evolutions of the frequency, amplitude, and coherence of the low-frequency quasi-periodic oscillation (LFQPO). We combined our timing results with the spectral study by Neilsen et al. to perform an elaborate comparison analysis. Our analyses show that the LFQPO frequency does not scale with the inner disk radius, but it is related to the spectral index, indicating a possible correlation between the LFQPO and the corona. The LFQPO amplitude spectrum and other results are naturally explained by tying the LFQPO to the corona. The similarities of the spectra of variability parameters between the LFQPOs from ρ state and those from more steady states indicate that the LFQPOs of GRS 1915+105 in very different states seem to share the same origin.

PHASE-RESOLVED TIMING ANALYSIS OF GRS 1915+105 IN ITS {rho} STATE

Energy Technology Data Exchange (ETDEWEB)

Yan, Shu-Ping; Wang, Na; Ding, Guo-Qiang [Xinjiang Astronomical Observatory, Chinese Academy of Sciences, 150 Science 1-Street, Urumqi, Xinjiang 830011 (China); Qu, Jin-Lu, E-mail: yanshup@xao.ac.cn, E-mail: na.wang@xao.ac.cn [Key Laboratory for Particle Astrophysics, Institute of High Energy Physics, Chinese Academy of Sciences, 19B Yuquan Road, Beijing 100049 (China)

2013-04-10

We made a phase-resolved timing analysis of GRS 1915+105 in its {rho} state and obtained detailed {rho} cycle evolutions of the frequency, amplitude, and coherence of the low-frequency quasi-periodic oscillation (LFQPO). We combined our timing results with the spectral study by Neilsen et al. to perform an elaborate comparison analysis. Our analyses show that the LFQPO frequency does not scale with the inner disk radius, but it is related to the spectral index, indicating a possible correlation between the LFQPO and the corona. The LFQPO amplitude spectrum and other results are naturally explained by tying the LFQPO to the corona. The similarities of the spectra of variability parameters between the LFQPOs from {rho} state and those from more steady states indicate that the LFQPOs of GRS 1915+105 in very different states seem to share the same origin.

Submicron Resolution Spectral-Domain Optical Coherence Tomography

KAUST Repository

Alarousu, Erkki

2013-11-14

Apparatuses and systems for submicron resolution spectral-domain optical coherence tomography (OCT) are disclosed. The system may use white light sources having wavelengths within 400-1000 nanometers, and achieve resolution below 1 .mu.m. The apparatus is aggregated into a unitary piece, and a user can connect the apparatus to a user provided controller and/or light source. The light source may be a supercontinuum source.

Advances in optical coherence tomography in dermatology-a review

Science.gov (United States)

Olsen, Jonas; Holmes, Jon; Jemec, Gregor B. E.

2018-04-01

Optical coherence tomography (OCT) was introduced as an imaging system, but like ultrasonography, other measures, such as blood perfusion and polarization of light, have enabled the technology to approach clinical utility. This review aims at providing an overview of the advances in clinical research based on the improving technical aspects. OCT provides cross-sectional and en face images down to skin depths of 0.4 to 2.00 mm with optical resolution of 3 to 15 μm. Dynamic optical coherence tomography (D-OCT) enables the visualization of cutaneous microvasculature via detection of rapid changes in the interferometric signal of blood flow. Nonmelanoma skin cancer (NMSC) is the most comprehensively investigated topic, resulting in improved descriptions of morphological features and diagnostic criteria. A refined scoring system for diagnosing NMSC, taking findings from conventional and D-OCT into account, is warranted. OCT diagnosis of melanoma is hampered by the resolution and the optical properties of melanin. D-OCT may be of value in diseases characterized with dynamic changes in the vasculature of the skin and the addition of functional measures is strongly encouraged. In conclusion, OCT in dermatology is still an emerging technology that has great potential for improving further in the future.

Optical coherence tomography and subclinical optical neuritis in longitudinally extensive transverse myelitis

Directory of Open Access Journals (Sweden)

Prakash Kumar Sinha

2017-01-01

Full Text Available Objective: The aim is to compare the retinal nerve fiber layer (RNFL thickness of longitudinally extensive transverse myelitis (LETM eyes without previous optic neuritis with that of healthy control subjects. Methods: Over 20 LETM eyes and 20 normal control eyes were included in the study and subjected to optical coherence tomography to evaluate and compare the RNFL thickness. Result: Significant RNFL thinning was observed at 8 o'clock position in LETM eyes as compared to the control eyes (P = 0.038. No significant differences were seen in other RNFL measurements. Conclusion: Even in the absence of previous optic neuritis LETM can lead to subclinical axonal damage leading to focal RNFL thinning.

Modeling light–tissue interaction in optical coherence tomography systems

DEFF Research Database (Denmark)

Andersen, Peter E.; Jørgensen, Thomas Martini; Thrane, Lars

2015-01-01

Optical coherence tomography (OCT) performs high-resolution, cross-sectional tomographic imaging of the internal tissue microstructure by measuring backscattered or backreflected light. The scope of this chapter is to present analytical and numerical models that are able to describe light-tissue ...

Time-resolved measurements of coherent structures in the turbulent boundary layer

Science.gov (United States)

LeHew, J. A.; Guala, M.; McKeon, B. J.

2013-04-01

Time-resolved particle image velocimetry was used to examine the structure and evolution of swirling coherent structure (SCS), one interpretation of which is a marker for a three-dimensional coherent vortex structure, in wall-parallel planes of a turbulent boundary layer with a large field of view, 4.3 δ × 2.2 δ. Measurements were taken at four different wall-normal locations ranging from y/ δ = 0.08-0.48 at a friction Reynolds number, Re τ = 410. The data set yielded statistically converged results over a larger field of view than typically observed in the literature. The method for identifying and tracking swirling coherent structure is discussed, and the resulting trajectories, convection velocities, and lifespan of these structures are analyzed at each wall-normal location. The ability of a model in which the entirety of an individual SCS travels at a single convection velocity, consistent with the attached eddy hypothesis of Townsend (The structure of turbulent shear flows. Cambridge University Press, Cambridge, 1976), to describe the data is investigated. A methodology for determining whether such structures are "attached" or "detached" from the wall is also proposed and used to measure the lifespan and convection velocity distributions of these different structures. SCS were found to persist for longer periods of time further from the wall, particularly those inferred to be "detached" from the wall, which could be tracked for longer than 5 eddy turnover times.

Coherent optical DFT-spread OFDM transmission using orthogonal band multiplexing.

Science.gov (United States)

Yang, Qi; He, Zhixue; Yang, Zhu; Yu, Shaohua; Yi, Xingwen; Shieh, William

2012-01-30

Coherent optical OFDM (CO-OFDM) combined with orthogonal band multiplexing provides a scalable and flexible solution for achieving ultra high-speed rate. Among many CO-OFDM implementations, digital Fourier transform spread (DFT-S) CO-OFDM is proposed to mitigate fiber nonlinearity in long-haul transmission. In this paper, we first illustrate the principle of DFT-S OFDM. We then experimentally evaluate the performance of coherent optical DFT-S OFDM in a band-multiplexed transmission system. Compared with conventional clipping methods, DFT-S OFDM can reduce the OFDM peak-to-average power ratio (PAPR) value without suffering from the interference of the neighboring bands. With the benefit of much reduced PAPR, we successfully demonstrate 1.45 Tb/s DFT-S OFDM over 480 km SSMF transmission.

Qualitative investigation of fresh human scalp hair with full-field optical coherence tomography

Science.gov (United States)

Choi, Woo June; Pi, Long-Quan; Min, Gihyeon; Lee, Won-Soo; Lee, Byeong Ha

2012-03-01

We have investigated depth-resolved cellular structures of unmodified fresh human scalp hairs with ultrahigh-resolution full-field optical coherence tomography (FF-OCT). The Linnik-type white light interference microscope has been home-implemented to observe the micro-internal layers of human hairs in their natural environment. In hair shafts, FF-OCT has qualitatively revealed the cellular hair compartments of cuticle and cortex layers involved in keratin filaments and melanin granules. No significant difference between black and white hair shafts was observed except for absence of only the melanin granules in the white hair, reflecting that the density of the melanin granules directly affects the hair color. Anatomical description of plucked hair bulbs was also obtained with the FF-OCT in three-dimensions. We expect this approach will be useful for evaluating cellular alteration of natural hairs on cosmetic assessment or diagnosis of hair diseases.

Applications of expectation maximization algorithm for coherent optical communication

DEFF Research Database (Denmark)

Carvalho, L.; Oliveira, J.; Zibar, Darko

2014-01-01

In this invited paper, we present powerful statistical signal processing methods, used by machine learning community, and link them to current problems in optical communication. In particular, we will look into iterative maximum likelihood parameter estimation based on expectation maximization...... algorithm and its application in coherent optical communication systems for linear and nonlinear impairment mitigation. Furthermore, the estimated parameters are used to build the probabilistic model of the system for the synthetic impairment generation....

Investigation of optical coherence tomography as an imaging modality in tissue engineering

International Nuclear Information System (INIS)

Yang Ying; Dubois, Arnaud; Qin Xiangpei; Li Jian; Haj, Alicia El; Wang, Ruikang K

2006-01-01

Monitoring cell profiles in 3D porous scaffolds presents a major challenge in tissue engineering. In this study, we investigate optical coherence tomography (OCT) as an imaging modality to monitor non-invasively both structures and cells in engineered tissue constructs. We employ time-domain OCT to visualize macro-structural morphology, and whole-field optical coherence microscopy to delineate the morphology of cells and constructs in a developing in vitro engineered bone tissue. The results show great potential for the use of OCT in non-invasive monitoring of cellular activities in 3D developing engineered tissues

Experimental 2.5 Gbit/s QPSK WDM coherent phase modulated radio-over-fibre link with digital demodulation by a K-means algorithm

DEFF Research Database (Denmark)

Guerrero Gonzalez, Neil; Caballero Jambrina, Antonio; Amaya Fernández, Ferney Orlando

2009-01-01

Highest reported bit rate of 2.5 Gbit/s for optically phase modulated radio-over-fibre link employing coherent detection is demonstrated. Demodulation of 3·2.5 Gbit/s QPSK modulated WDM channels, is achieved after 79km of transmission through deployed fiber....

Coherent cavity-enhanced dual-comb spectroscopy.

Science.gov (United States)

Fleisher, Adam J; Long, David A; Reed, Zachary D; Hodges, Joseph T; Plusquellic, David F

2016-05-16

Dual-comb spectroscopy allows for the rapid, multiplexed acquisition of high-resolution spectra without the need for moving parts or low-resolution dispersive optics. This method of broadband spectroscopy is most often accomplished via tight phase locking of two mode-locked lasers or via sophisticated signal processing algorithms, and therefore, long integration times of phase coherent signals are difficult to achieve. Here we demonstrate an alternative approach to dual-comb spectroscopy using two phase modulator combs originating from a single continuous-wave laser capable of > 2 hours of coherent real-time averaging. The dual combs were generated by driving the phase modulators with step-recovery diodes where each comb consisted of > 250 teeth with 203 MHz spacing and spanned > 50 GHz region in the near-infrared. The step-recovery diodes are passive devices that provide low-phase-noise harmonics for efficient coupling into an enhancement cavity at picowatt optical powers. With this approach, we demonstrate the sensitivity to simultaneously monitor ambient levels of CO2, CO, HDO, and H2O in a single spectral region at a maximum acquisition rate of 150 kHz. Robust, compact, low-cost and widely tunable dual-comb systems could enable a network of distributed multiplexed optical sensors.

Agreement of angle closure assessments between gonioscopy, anterior segment optical coherence tomography and spectral domain optical coherence tomography

OpenAIRE

Tay, Elton Lik Tong; Yong, Vernon Khet Yau; Lim, Boon Ang; Sia, Stelson; Wong, Elizabeth Poh Ying; Yip, Leonard Wei Leon

2015-01-01

AIM: To determine angle closure agreements between gonioscopy and anterior segment optical coherence tomography (AS-OCT), as well as gonioscopy and spectral domain OCT (SD-OCT). A secondary objective was to quantify inter-observer agreements of AS-OCT and SD-OCT assessments. METHODS: Seventeen consecutive subjects (33 eyes) were recruited from the study hospital’s Glaucoma clinic. Gonioscopy was performed by a glaucomatologist masked to OCT results. OCT images were read independently by 2 ...

Control of phase transition dynamics in media with nanoscale nonuniformities by coherence loss spectroscopy

International Nuclear Information System (INIS)

Brodsky, Anatol M

2010-01-01

The optical nondestructive characterization of chemical transformation dynamics and diffusion kinetics, including phase transitions, in heterogeneous media with a random distribution of nanoparticles (nano-nonuniformities), is of great theoretical and practical importance. Such characterization, with the help of coherence loss spectroscopy, considered in this paper can be applied for the control of a number of industrial processes dynamics, environmental monitoring, and medical diagnostics and therapy. As a specific example, the growth of crystal nuclei (embrions) as a result of the diffusion to them of a substance from the surrounding supersaturated solution is considered

Heartbeat OCT: In vivo intravascular megahertz-optical coherence tomography

NARCIS (Netherlands)

T. Wang (Tianshi); A.F.H. Pfeiffer (Andreas); E.S. Regar (Eveline); W. Wieser (Wolfgang); H.M.M. van Beusekom (Heleen); C.T. Lancée (Charles); T. Springeling (Tirza); I. Krabbendam (Ilona); A.F.W. van der Steen (Ton); R. Huber (Roman); G. van Soest (Gijs)

2015-01-01

textabstractCardiac motion artifacts, non-uniform rotational distortion and undersampling affect the image quality and the diagnostic impact of intravascular optical coherence tomography (IV-OCT). In this study we demonstrate how these limitations of IV-OCT can be addressed by using an imaging

Application of optical coherence tomography angiography for diabetic retinopathy

Directory of Open Access Journals (Sweden)

Qing Liu

2016-04-01

Full Text Available Optical coherence tomography angiography(OCTAis a new emerging technology of the optical coherence tomography(OCTin recent years. It's a noninvasive and fast retinal vascular imaging technology with high resolution, and has been gradually applied to make diagnosis, gives treatment and follow-up for various types of retinal vascular diseases, such as diabetic retinopathy, choroid neovascularization, etc. OCTA has the unique advantages of layered observing the structure and shape of the chorioretinal vascular at different levels, and quantifying the blood flow index of designated scope and the flow area of lesions. However, OCTA requires high solid vision and good cooperation of patients, even has the limitations to observe the retinal scope and retinal vascular barrier function. With overcoming these limitations, it's helpful for us to improve the understanding of retinal vascular diseases, consummate the diagnosis and treatment and observation of retinal vascular diseases.

Stabilization of Phase of a Sinusoidal Signal Transmitted Over Optical Fiber

Science.gov (United States)

DAddario, Larry R.; Trink, Joseph T.

2010-01-01

In the process of connecting widely distributed antennas into a coherent array, it is necessary to synchronize the timing of signals at the various locations. This can be accomplished by distributing a common reference signal from a central source, usually over optical fiber. A high-frequency (RF or microwave) tone is a good choice for the reference. One difficulty is that the effective length of the optical fiber changes with temperature and mechanical stress, leading to phase instability in the received tone. This innovation provides a new way to stabilize the phase of the received tone, in spite of variations in the electrical length of the fiber. Stabilization is accomplished by two-way transmission in which part of the received signal is returned to the transmitting end over an identical fiber. The returned signal is detected and used to close an electrical servo loop whose effect is to keep constant the phase of the tone at the receiving end.

The Diamond Beamline I13L for Imaging and Coherence

International Nuclear Information System (INIS)

Rau, C.; Wagner, U.; Peach, A.; Singh, B.; Wilkin, G.; Jones, C.; Robinson, I. K.

2010-01-01

I13L is the first long beamline at Diamond dedicated to imaging and coherence. Two independent branches will operate in the energy range of 6-30 keV with spatial resolution on the micro- to nano-lengthscale. The Imaging branch is dedicated to imaging and tomography with In-line phase contrast and full-field microscopy on the micron to nano-length scale. Ultimate resolution will be achieved on the Coherence branch at I13L with imaging techniques in the reciprocal space. The experimental stations will be located about 250 m from the source, taking advantage of the coherence properties of the source. The beamline has some outstanding features such as the mini-beta layout of the storage ring's straight section. The optical layout is optimized for beam stability and high optical quality to preserve the coherent radiation. In the experimental stations several methods will be available, starting for the first user with in-line phase contrast imaging on the imaging branch and Coherent X-ray Diffraction (CXRD) on the coherence branch.

Optical Biopsy Using Tissue Spectroscopy and Optical Coherence Tomography

Directory of Open Access Journals (Sweden)

Norman S Nishioka

2003-01-01

Full Text Available ‘Optical biopsy’ or ‘optical diagnostics’ is a technique whereby light energy is used to obtain information about the structure and function of tissues without disrupting them. In fluorescence spectroscopy, light energy (usually provided by a laser is used to excite tissues and the resulting fluorescence provides information about the target tissue. Its major gastrointestinal application has been in the evaluation of colonic polyps, in which it can reliably distinguish malignant from benign lesions. Optical coherence tomography (OCT has been used in the investigation of Barrett’s epithelium (and dysplasia, although a variety of other applications are feasible. For example, OCT could assist in the identification and staging of mucosal and submucosal neoplasms, the grading of inflammation in the stomach and intestine, the diagnosis of biliary tumours and the assessment of villous architecture. OCT differs from endoscopic ultrasound, a complementary modality, in that it has a much higher resolution but lesser depth of penetration. The images correlate with the histopathological appearance of tissues, and the addition of Doppler methods may enable it to evaluate the vascularity of tumours and the amount of blood flow in varices. Refinements in these new optical techniques will likely make them valuable in clinical practice, although their specific roles have yet to be determined.

Time-Resolved Speckle Analysis: A New Approach to Coherence and Dephasing of Optical Excitations in Solids

DEFF Research Database (Denmark)

Langbein, Wolfgang Werner; Hvam, Jørn Märcher; Zimmermann, R.

1999-01-01

). This method determines the decays of intensity and coherence separately, thus distinguishing lifetime from pure dephasing. The secondary emission of excitons in semiconductor quantum wells is investigated. Here the combination of static disorder and inelastic scattering leads to a partially coherent emission....... The temperature dependence is well explained by phonon scattering....

Donor disc attachment assessment with intraoperative spectral optical coherence tomography during descemet stripping automated endothelial keratoplasty

Directory of Open Access Journals (Sweden)

Edward Wylegala

2013-01-01

Full Text Available Optical coherence tomography has already been proven to be useful for pre- and post-surgical anterior eye segment assessment, especially in lamellar keratoplasty procedures. There is no evidence for intraoperative usefulness of optical coherence tomography (OCT. We present a case report of the intraoperative donor disc attachment assessment with spectral-domain optical coherence tomography in case of Descemet stripping automated endothelial keratoplasty (DSAEK surgery combined with corneal incisions. The effectiveness of the performed corneal stab incisions was visualized directly by OCT scan analysis. OCT assisted DSAEK allows the assessment of the accuracy of the Descemet stripping and donor disc attachment.

Low-cost coherent receiver for long-reach optical access network using single-ended detection.

Science.gov (United States)

Zhang, Xuebing; Li, Zhaohui; Li, Jianping; Yu, Changyuan; Lau, Alan Pak Tao; Lu, Chao

2014-09-15

A low-cost coherent receiver using two 2×3 optical hybrids and single-ended detection is proposed for long-reach optical access network. This structure can detect the two polarization components of polarization division multiplexing (PDM) signals. Polarization de-multiplexing and signal-to-signal beat interference (SSBI) cancellation are realized by using only three photodiodes. Simulation results for 40 Gb/s PDM-OFDM transmissions indicate that the low-cost coherent receiver has 3.2 dB optical signal-to-noise ratio difference compared with the theoretical value.

Heterodyne detection using spectral line pairing for spectral phase encoding optical code division multiple access and dynamic dispersion compensation.

Science.gov (United States)

Yang, Yi; Foster, Mark; Khurgin, Jacob B; Cooper, A Brinton

2012-07-30

A novel coherent optical code-division multiple access (OCDMA) scheme is proposed that uses spectral line pairing to generate signals suitable for heterodyne decoding. Both signal and local reference are transmitted via a single optical fiber and a simple balanced receiver performs sourceless heterodyne detection, canceling speckle noise and multiple-access interference (MAI). To validate the idea, a 16 user fully loaded phase encoded system is simulated. Effects of fiber dispersion on system performance are studied as well. Both second and third order dispersion management is achieved by using a spectral phase encoder to adjust phase shifts of spectral components at the optical network unit (ONU).

LDRD final report on theory and exploration of quantum-dot optical nonlinearities and coherences

International Nuclear Information System (INIS)

Chow, Weng Wah

2008-01-01

A microscopic theory for investigating quantum-dot optical properties was developed. The theory incorporated advances on various aspects of quantum-dot physics developed at Sandia and elsewhere. Important components are a non-Markovian treatment of polarization dephasing due to carrier-carrier scattering (developed at Sandia) and a nonperturbative treatment within a polaron picture of the scattering of carriers by longitudinal-optical phonons (developed at Bremen University). A computer code was also developed that provides a detailed accounting of electronic structure influences and a consistent treatment of many-body effects, the latter via the incorporation of results from the microscopic theory. This code was used to explore quantum coherence physics in a quantum-dot system. The investigation furthers the understanding of the underlying differences between atomic quantum coherence and semiconductor quantum coherence, and helps improve the potential of using quantum coherences in quantum computing, coherent control and high-resolution spectroscopy

Time and spectrum-resolving multiphoton correlator for 300–900 nm

Energy Technology Data Exchange (ETDEWEB)

Johnsen, Kelsey D.; Thibault, Marilyne; Jennewein, Thomas [Institute for Quantum Computing and Department for Physics and Astronomy, University of Waterloo, 200 University Ave. West, Waterloo, Ontario N2L 3G1 (Canada); Kolenderski, Piotr, E-mail: kolenderski@fizyka.umk.pl [Institute for Quantum Computing and Department for Physics and Astronomy, University of Waterloo, 200 University Ave. West, Waterloo, Ontario N2L 3G1 (Canada); Faculty of Physics, Astronomy and Informatics, Institute of Physics, Nicolaus Copernicus University, Grudziadzka 5, 87-100 Torun (Poland); Scarcella, Carmelo; Tosi, Alberto [Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133 Milano (Italy)

2014-10-14

We demonstrate a single-photon sensitive spectrometer in the visible range, which allows us to perform time-resolved and multi-photon spectral correlation measurements at room temperature. It is based on a monochromator composed of two gratings, collimation optics, and an array of single photon avalanche diodes. The time resolution can reach 110 ps and the spectral resolution is 2 nm/pixel, limited by the design of the monochromator. This technique can easily be combined with commercial monochromators and can be useful for joint spectrum measurements of two photons emitted in the process of parametric down conversion, as well as time-resolved spectrum measurements in optical coherence tomography or medical physics applications.

Coherent spin-rotational dynamics of oxygen superrotors

Science.gov (United States)

Milner, Alexander A.; Korobenko, Aleksey; Milner, Valery

2014-09-01

We use state- and time-resolved coherent Raman spectroscopy to study the rotational dynamics of oxygen molecules in ultra-high rotational states. While it is possible to reach rotational quantum numbers up to N≈ 50 by increasing the gas temperature to 1500 K, low population levels and gas densities result in correspondingly weak optical response. By spinning {{O}2} molecules with an optical centrifuge, we efficiently excite extreme rotational states with N≤slant 109 in high-density room temperature ensembles. Fast molecular rotation results in the enhanced robustness of the created rotational wave packets against collisions, enabling us to observe the effects of weak spin-rotation coupling in the coherent rotational dynamics of oxygen. The decay rate of spin-rotational coherence due to collisions is measured as a function of the molecular angular momentum and its dependence on the collisional adiabaticity parameter is discussed. We find that at high values of N, the rotational decoherence of oxygen is much faster than that of the previously studied non-magnetic nitrogen molecules, pointing at the effects of spin relaxation in paramagnetic gases.

In vivo sweat film layer thickness measured with Fourier-domain optical coherence tomography

CSIR Research Space (South Africa)

Jonathan, E

2008-01-01

Full Text Available s Centre form the f th s pr t fi d id Keywords: Fourier-domain optical coherence tomography; Human sweat secretion; Sweat gland; Sweat duct; Hyperhidrosis growing list of triggers include cancer, glucose control disorder, mental stress, social..., that is, the gland, duct and pore(s). However, due to a slow imaging time, COCT is largely restricted to morphometry of human tissue and thickness measurement of biologic and biologic samples [12,13]. ARTICLE IN PRESS Fourier-domain optical coherence...

Resolving molecular vibronic structure using high-sensitivity two-dimensional electronic spectroscopy

Energy Technology Data Exchange (ETDEWEB)

Bizimana, Laurie A.; Brazard, Johanna; Carbery, William P.; Gellen, Tobias; Turner, Daniel B., E-mail: dturner@nyu.edu [Department of Chemistry, New York University, 100 Washington Square East, New York, New York 10003 (United States)

2015-10-28

Coherent multidimensional optical spectroscopy is an emerging technique for resolving structure and ultrafast dynamics of molecules, proteins, semiconductors, and other materials. A current challenge is the quality of kinetics that are examined as a function of waiting time. Inspired by noise-suppression methods of transient absorption, here we incorporate shot-by-shot acquisitions and balanced detection into coherent multidimensional optical spectroscopy. We demonstrate that implementing noise-suppression methods in two-dimensional electronic spectroscopy not only improves the quality of features in individual spectra but also increases the sensitivity to ultrafast time-dependent changes in the spectral features. Measurements on cresyl violet perchlorate are consistent with the vibronic pattern predicted by theoretical models of a highly displaced harmonic oscillator. The noise-suppression methods should benefit research into coherent electronic dynamics, and they can be adapted to multidimensional spectroscopies across the infrared and ultraviolet frequency ranges.

Optical-wireless-optical full link for polarization multiplexing quadrature amplitude/phase modulation signal transmission.

Science.gov (United States)

Li, Xinying; Yu, Jianjun; Chi, Nan; Zhang, Junwen

2013-11-15

We propose and experimentally demonstrate an optical wireless integration system at the Q-band, in which up to 40 Gb/s polarization multiplexing multilevel quadrature amplitude/phase modulation (PM-QAM) signal can be first transmitted over 20 km single-mode fiber-28 (SMF-28), then delivered over a 2 m 2 × 2 multiple-input multiple-output wireless link, and finally transmitted over another 20 km SMF-28. The PM-QAM modulated wireless millimeter-wave (mm-wave) signal at 40 GHz is generated based on the remote heterodyning technique, and demodulated by the radio-frequency transparent photonic technique based on homodyne coherent detection and baseband digital signal processing. The classic constant modulus algorithm equalization is used at the receiver to realize polarization demultiplexing of the PM-QAM signal. For the first time, to the best of our knowledge, we realize the conversion of the PM-QAM modulated wireless mm-wave signal to the optical signal as well as 20 km fiber transmission of the converted optical signal.

Optical coherence tomography of the newborn airway.

Science.gov (United States)

Ridgway, James M; Su, Jianping; Wright, Ryan; Guo, Shuguang; Kim, David C; Barretto, Roberto; Ahuja, Gurpreet; Sepehr, Ali; Perez, Jorge; Sills, Jack H; Chen, Zhongping; Wong, Brian J F

2008-05-01

Acquired subglottic stenosis in a newborn is often associated with prolonged endotracheal intubation. This condition is generally diagnosed during operative endoscopy after airway injury has occurred. Unfortunately, endoscopy is unable to characterize the submucosal changes observed in such airway injuries. Other modalities, such as magnetic resonance imaging, computed tomography, and ultrasound, do not possess the necessary level of resolution to differentiate scar, neocartilage, and edema. Optical coherence tomography (OCT) is an imaging modality that produces high-resolution, cross-sectional images of living tissue (8 to 20 microm). We examined the ability of this noninvasive technique to characterize the newborn airway in a prospective clinical trial. Twelve newborn patients who required ventilatory support underwent OCT airway imaging. Comparative analysis of intubated and non-intubated states was performed. Imaging of the supraglottis, glottis, subglottis, and trachea was performed in 12 patients, revealing unique tissue characteristics as related to turbidity, signal backscattering, and architecture. Multiple structures were identified, including the vocal folds, cricoid cartilage, tracheal rings, ducts, glands, and vessels. Optical coherence tomography clearly identifies in vivo tissue layers and regional architecture while offering detailed information concerning tissue microstructures. The diagnostic potential of this technology makes OCT a promising modality in the study and surveillance of the neonatal airway.

Detection and Diagnosis of Oral Neoplasia with an Optical Coherence Microscope

National Research Council Canada - National Science Library

Clark, Anne

2003-01-01

.... The technique combines the sub-cellular resolution of high numerical aperture (NA) confocal microscopy with the increased sensitivity and penetration depth of optical coherence tomography (OCT...

Contribution of optical coherence tomography imaging in management of iatrogenic coronary dissection

Energy Technology Data Exchange (ETDEWEB)

Barber-Chamoux, Nicolas, E-mail: nbarber-chamoux@chu-clermontferrand.fr [Department of Cardiology, Gabriel Montpied University Hospital, Clermont-Ferrand (France); Souteyrand, Géraud; Combaret, Nicolas [Department of Cardiology, Gabriel Montpied University Hospital, Clermont-Ferrand (France); ISIT, CaVITI, CNRS (UMR-6284), Auvergne University, Clermont-Ferrand (France); Ouedraogo, Edgar; Lusson, Jean René [Department of Cardiology, Gabriel Montpied University Hospital, Clermont-Ferrand (France); Motreff, Pascal [Department of Cardiology, Gabriel Montpied University Hospital, Clermont-Ferrand (France); ISIT, CaVITI, CNRS (UMR-6284), Auvergne University, Clermont-Ferrand (France)

2016-03-15

Iatrogenic coronary dissection is a rare but potentially serious complication of coronary angiography and angioplasty. Treatment with angioplasty guided only by angiography is often difficult. Optical coherence tomography imaging seems to be an interesting technique to lead the management of iatrogenic coronary dissection. Diagnosis can be made by optical coherence tomography; it can also eliminate differential diagnosis. Furthermore, this technique can guide safely the endovascular treatment. - Highlights: • Iatrogenic coronary dissection remains a challenging problem in angiography. • Endocoronary imaging is helpful for the diagnosis of iatrogenic coronary dissection. • OCT is a safe option to manage the endovascular treatment of coronary dissection.

Diffusion tensor optical coherence tomography

Science.gov (United States)

Marks, Daniel L.; Blackmon, Richard L.; Oldenburg, Amy L.

2018-01-01

In situ measurements of diffusive particle transport provide insight into tissue architecture, drug delivery, and cellular function. Analogous to diffusion-tensor magnetic resonance imaging (DT-MRI), where the anisotropic diffusion of water molecules is mapped on the millimeter scale to elucidate the fibrous structure of tissue, here we propose diffusion-tensor optical coherence tomography (DT-OCT) for measuring directional diffusivity and flow of optically scattering particles within tissue. Because DT-OCT is sensitive to the sub-resolution motion of Brownian particles as they are constrained by tissue macromolecules, it has the potential to quantify nanoporous anisotropic tissue structure at micrometer resolution as relevant to extracellular matrices, neurons, and capillaries. Here we derive the principles of DT-OCT, relating the detected optical signal from a minimum of six probe beams with the six unique diffusion tensor and three flow vector components. The optimal geometry of the probe beams is determined given a finite numerical aperture, and a high-speed hardware implementation is proposed. Finally, Monte Carlo simulations are employed to assess the ability of the proposed DT-OCT system to quantify anisotropic diffusion of nanoparticles in a collagen matrix, an extracellular constituent that is known to become highly aligned during tumor development.

Early detection of tooth wear by en-face optical coherence tomography

Science.gov (United States)

Mărcăuteanu, Corina; Negrutiu, Meda; Sinescu, Cosmin; Demjan, Eniko; Hughes, Mike; Bradu, Adrian; Dobre, George; Podoleanu, Adrian G.

2009-02-01

Excessive dental wear (pathological attrition and/or abfractions) is a frequent complication in bruxing patients. The parafunction causes heavy occlusal loads. The aim of this study is the early detection and monitoring of occlusal overload in bruxing patients. En-face optical coherence tomography was used for investigating and imaging of several extracted tooth, with a normal morphology, derived from patients with active bruxism and from subjects without parafunction. We found a characteristic pattern of enamel cracks in patients with first degree bruxism and with a normal tooth morphology. We conclude that the en-face optical coherence tomography is a promising non-invasive alternative technique for the early detection of occlusal overload, before it becomes clinically evident as tooth wear.

Resonant acoustic radiation force optical coherence elastography

OpenAIRE

Qi, Wenjuan; Li, Rui; Ma, Teng; Li, Jiawen; Kirk Shung, K.; Zhou, Qifa; Chen, Zhongping

2013-01-01

We report on a resonant acoustic radiation force optical coherence elastography (ARF-OCE) technique that uses mechanical resonant frequency to characterize and identify tissues of different types. The linear dependency of the resonant frequency on the square root of Young's modulus was validated on silicone phantoms. Both the frequency response spectrum and the 3D imaging results from the agar phantoms with hard inclusions confirmed the feasibility of deploying the resonant frequency as a mec...

A Micromotor Catheter for Intravascular Optical Coherence Tomography

Directory of Open Access Journals (Sweden)

Tianshi Wang

2015-03-01

Full Text Available We have developed a new form of intravascular optical coherence tomography (IV-OCT that allows the extremely fast acquisition of high-resolution images of the coronary arteries. This process leads to much better image quality by eliminating cardiac motion artefacts and undersampling. It relies on a catheter that incorporates a synchronous micromotor with a diameter of 1.0 mm and a rotational speed of up to 5600 revolutions per second, enabling an IV-OCT frame rate of 5.6 kHz. This speed is matched by a wavelength-swept laser that generates up to 2.8 million image lines per second. With this setup, our team achieved IV-OCT imaging of up to 5600 frames per second (fps in vitro and 4000 fps in vivo, deployed at a 100 mm·s−1 pullback velocity. The imaging session is triggered by the electrocardiogram of the subject, and can scan a coronary artery in the phase of the heartbeat where the heart is at rest, providing a name for this new technology: the “Heartbeat OCT.”

Simultaneous measurements of global vibrational spectra and dephasing times of molecular vibrational modes by broadband time-resolved coherent anti-Stokes Raman scattering spectrography

International Nuclear Information System (INIS)

Yin Jun; Yu Ling-Yao; Liu Xing; Wan Hui; Lin Zi-Yang; Niu Han-Ben

2011-01-01

In broadband coherent anti-Stokes Raman scattering (CARS) spectroscopy with supercontinuum (SC), the simultaneously detectable spectral coverage is limited by the spectral continuity and the simultaneity of various spectral components of SC in an enough bandwidth. By numerical simulations, the optimal experimental conditions for improving the SC are obtained. The broadband time-resolved CARS spectrography based on the SC with required temporal and spectral distributions is realised. The global molecular vibrational spectrum with well suppressed nonresonant background noise can be obtained in a single measurement. At the same time, the measurements of dephasing times of various molecular vibrational modes can be conveniently achieved from intensities of a sequence of time-resolved CARS signals. It will be more helpful to provide a complete picture of molecular vibrations, and to exhibit a potential to understand not only both the solvent dynamics and the solute-solvent interactions, but also the mechanisms of chemical reactions in the fields of biology, chemistry and material science. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)