Sample records for pharmacology section ireland

  1. Refusal of emergency caesarean section in Ireland: a relational approach. (United States)

    Wade, Katherine


    This article examines the issue of emergency caesarean section refusal. This raises complex legal and ethical issues surrounding autonomy, capacity, and the right to refuse treatment. In Ireland, the situation is complicated further by the constitutional right to life of the unborn. While cases involving caesarean section refusal have occurred in other jurisdictions, a case of this nature has yet to be reported in Ireland. This article examines possible ways in which the interaction of a woman's right to refuse treatment and the right to life of the unborn could be approached in Ireland in the context of caesarean section refusal. The central argument of the article is that the liberal individualistic approach to autonomy evident in the caesarean section cases in England and Wales is difficult to apply in the Irish context, due to the conflicting constitutional rights of the woman and foetus. Thus, alternative visions of autonomy which take the interests and rights of others into account in medical decision-making are examined. In particular, this article focuses on the concept of relational consent, as developed by Alasdair Maclean and examines how such an approach could be applied in the context of caesarean section refusal in Ireland. The article explains why this approach is particularly appropriate and identifies mechanisms through which such a theory of consent could be applied. It is argued that this approach enhances a woman's right to autonomy, while at the same time allows the right to life of the unborn to be defended.

  2. National Variation in Caesarean Section Rates: A Cross Sectional Study in Ireland.

    LENUS (Irish Health Repository)

    Sinnott, Sarah-Jo


    Internationally, caesarean section (CS) rates are rising. However, mean rates of CS across providers obscure extremes of CS provision. We aimed to quantify variation between all maternity units in Ireland.

  3. Robust resilience and substantial interest: a survey of pharmacological cognitive enhancement among university students in the UK and Ireland.

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    Ilina Singh

    Full Text Available Use of 'smart drugs' among UK students is described in frequent media reports as a rapidly increasing phenomenon. This article reports findings from the first large-scale survey of pharmacological cognitive enhancement (PCE among students in the UK and Ireland. Conducted from February to September 2012, a survey of a convenience sample of 877 students measured PCE prevalence, attitudes, sources, purposes and ethics. Descriptive and logistic regression statistical methods were used to analyse the data. Lifetime prevalence of PCE using modafinil, methylphenidate or Adderall was under 10%, while past regular and current PCE users of these substances made up between 0.3%-4% of the survey population. A substantial majority of students was unaware of and/or uninterested in PCE; however about one third of students were interested in PCE. PCE users were more likely to be male, British and older students; predictors of PCE use included awareness of other students using PCEs, ADHD symptomatology, ethical concerns, and alcohol and cannabis use. The survey addresses the need for better evidence about PCE prevalence and practices among university students in the UK. We recommend PCE-related strategies for universities based on the survey findings.

  4. Usage of unscheduled hospital care by homeless individuals in Dublin, Ireland: a cross-sectional study. (United States)

    Ní Cheallaigh, Clíona; Cullivan, Sarah; Sears, Jess; Lawlee, Ann Marie; Browne, Joe; Kieran, Jennifer; Segurado, Ricardo; O'Carroll, Austin; O'Reilly, Fiona; Creagh, Donnacha; Bergin, Colm; Kenny, Rose Anne; Byrne, Declan


    Homeless people lack a secure, stable place to live and experience higher rates of serious illness than the housed population. Studies, mainly from the USA, have reported increased use of unscheduled healthcare by homeless individuals.We sought to compare the use of unscheduled emergency department (ED) and inpatient care between housed and homeless hospital patients in a high-income European setting in Dublin, Ireland. A large university teaching hospital serving the south inner city in Dublin, Ireland. Patient data are collected on an electronic patient record within the hospital. We carried out an observational cross-sectional study using data on all ED visits (n=47 174) and all unscheduled admissions under the general medical take (n=7031) in 2015. The address field of the hospital's electronic patient record was used to identify patients living in emergency accommodation or rough sleeping (hereafter referred to as homeless). Data on demographic details, length of stay and diagnoses were extracted. In comparison with housed individuals in the hospital catchment area, homeless individuals had higher rates of ED attendance (0.16 attendances per person/annum vs 3.0 attendances per person/annum, respectively) and inpatient bed days (0.3 vs 4.4 bed days/person/annum). The rate of leaving ED before assessment was higher in homeless individuals (40% of ED attendances vs 15% of ED attendances in housed individuals). The mean age of homeless medical inpatients was 44.19 years (95% CI 42.98 to 45.40), whereas that of housed patients was 61.20 years (95% CI 60.72 to 61.68). Homeless patients were more likely to terminate an inpatient admission against medical advice (15% of admissions vs 2% of admissions in homeless individuals). Homeless patients represent a significant proportion of ED attendees and medical inpatients. In contrast to housed patients, the bulk of usage of unscheduled care by homeless people occurs in individuals aged 25-65 years. © Article author

  5. Pressure ulcer prevalence and prevention practices: a cross-sectional comparative survey in Norway and Ireland. (United States)

    Moore, Z; Johansen, E; Etten, M van; Strapp, H; Solbakken, T; Smith, B Eskerud; Faulstich, J


    This study explored whether the risk assessment method, structured versus clinical judgment, influences pressure ulcer (PU) prevalence or prevention strategies. A cross section survey design was employed with use of a pre-designed data collection instrument. Following ethical approval and consent, data was gathered from two acute care settings, one in Norway (clinical judgment) and one in Ireland (structured risk assessment using the Maelor Score). Data were obtained from 180 patients, 59 in Norway and 121 in Ireland. Of the patients 48% were male and 49% were female, gender was not recorded for 3%. The most common age bracket was 70-99 years of age, 46% of the study population. PU prevalence was 54% in the Norwegian site with the majority of PUs (69%) being category 1, and 12% in the Irish site with the majority (50%) being category 2. Only 8% of patients in the Norwegian site were risk assessed on admission compared with 85% in the Irish site. No dynamic mattresses and four pressure redistribution cushions were in use in the Norwegian site, whereas, in the Irish site, 27 dynamic mattresses and 11 pressure redistribution cushions were used, the majority (44%) for high-risk individuals. Of those at risk of PU development, 15% in the Norwegian site and 56% in the Irish site had a documented repositioning care plan when in bed, and 0% in the Norwegian site and 13% in the Irish site for when seated on a chair. There were inconsistencies in approach to PU risk assessment and prevention across the two clinical settings. However, prevalence rates differed, mainly relating to category 1 PU damage. Even though formal risk assessment is well established in the Irish site, this is not necessarily followed up with appropriated PU prevention. Thus, the method of risk assessment does not seem to influence subsequent care planning, questioning the role of formal risk assessment; however, despite this, risk assessment does put a focus on an important clinical problem. In the

  6. The influence of ethnicity on breastfeeding rates in Ireland: a cross-sectional study. (United States)

    Ladewig, Emma L; Hayes, Catherine; Browne, John; Layte, Richard; Reulbach, Udo


    Historically, breastfeeding rates in Ireland have been low compared with international averages. It has been suggested that maternal ethnicity and citizenship may influence breastfeeding rates, with ethnic minorities thought more likely to breast feed. The aim of this study is to investigate the association among maternal citizenship, ethnicity, birthplace and breast feeding. It is hypothesised that Irish mothers (identified through Irish citizenship, self-identified Irish ethnicity or Irish birthplace) are less likely to breast feed than non-Irish mothers. The study population of Growing Up in Ireland: the National Longitudinal Study of Children was used for this study. Analysis was restricted to 11 092 biological mother and infant pairs with a complete breastfeeding history. Logistic regression analysis was used to estimate ORs and 95% CIs for breast feeding relative to maternal citizenship and ethnicity, controlling for the confounding effects of other maternal variables. Results indicated that 55.9% (6202 of 11 092) of mothers had initiated breast feeding, with only 7.9% (874 of 11 092) of mothers currently breast feeding their infant (at 9 months of age). Irish citizens (4693 of 9368, 50.0%) were significantly less likely to have initiated breast feeding compared with non-Irish citizens (1503 of 1695, 88.7%). Irish born mothers (4179 of 8627, 48.8%) were also significantly less likely to have initiated breast feeding than mothers born elsewhere (2023 of 2462, 82.2%). Maternal citizenship and ethnicity appear to be the strongest influencing factors on breastfeeding initiation and duration. However, this raises a possibility that the increase in breastfeeding rates seen recently may be the result of increased immigration into Ireland, rather than the success of policy and research efforts.

  7. Codeine use, dependence and help-seeking behaviour in the UK and Ireland: an online cross-sectional survey. (United States)

    Kimergård, A; Foley, M; Davey, Z; Dunne, J; Drummond, C; Deluca, P


    Codeine misuse and dependence poses a clinical and public health challenge. However, little is known about dependence and treatment needs in the UK and Ireland. To characterize codeine use, dependence and help-seeking behaviour. An online cross-sectional survey advertised on Facebook, Twitter, health and drug websites and e-mail circulars. The survey collected data on demographics and codeine use amongst adults from the UK and Ireland. The Severity of Dependence Scale measured the level of codeine dependence. The sample of 316 respondents had a mean age of 35.3 years (SD = 12.3) and 67% were women. Of the 316 respondents, 54 scored ≥5 on the Severity of Dependence Scale indicating codeine dependence (17.1%). Our study found that codeine dependence is a problem with both prescribed and 'over-the-counter' codeine. Codeine dependence was associated with daily use of codeine, faking or exaggerating symptoms to get a prescription for codeine and 'pharmacy shopping' ( P addiction treatment demand through increased identification and referrals in primary care. © The Author 2017. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email:

  8. Completeness and timeliness of Salmonella notifications in Ireland in 2008: a cross sectional study

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    Cormican Martin


    Full Text Available Abstract Background In Ireland, salmonellosis is the second most common cause of bacterial gastroenteritis. A new electronic system for reporting (Computerised Infectious Disease Reporting - CIDR of Salmonella cases was established in 2004. It collates clinical (and/or laboratory data on confirmed and probable Salmonella cases. The authors studied the completeness and the timeliness of Salmonella notifications in 2008. Methods This analysis was based upon laboratory confirmed cases of salmonella gastroenteritis. Using data contained in CIDR, we examined completeness for certain non-mandatory fields (country of infection, date of onset of illness, organism, outcome, patient type, and ethnicity. We matched the CIDR data with the dataset provided by the national Salmonella reference laboratory (NSRL to which all Salmonella spp. isolates are referred for definitive typing. We calculated the main median time intervals in the flow of events of the notification process. Results In total, 416 laboratory confirmed Salmonella cases were captured by the national surveillance system and the NSRL and were included in the analysis. Completeness of non mandatory fields varied considerably. Organism was the most complete field (98.8%, ethnicity the least (11%. The median time interval between sample collection (first contact of the patient with the healthcare professional to the first notification to the regional Department of Public Health (either a clinical or a laboratory notification was 6 days (Interquartile 4-7 days. The median total identification time interval, time between sample collections to availability of serotyping and phage-typing results on the system was 25 days (Interquartile 19-32 days. Timeliness varied with respect to Salmonella species. Clinical notifications occurred more rapidly than laboratory notifications. Conclusions Further feedback and education should be given to health care professionals to improve completeness of reporting of

  9. Completeness and timeliness of Salmonella notifications in Ireland in 2008: a cross sectional study

    LENUS (Irish Health Repository)

    Nicolay, Nathalie


    Abstract Background In Ireland, salmonellosis is the second most common cause of bacterial gastroenteritis. A new electronic system for reporting (Computerised Infectious Disease Reporting - CIDR) of Salmonella cases was established in 2004. It collates clinical (and\\/or laboratory) data on confirmed and probable Salmonella cases. The authors studied the completeness and the timeliness of Salmonella notifications in 2008. Methods This analysis was based upon laboratory confirmed cases of salmonella gastroenteritis. Using data contained in CIDR, we examined completeness for certain non-mandatory fields (country of infection, date of onset of illness, organism, outcome, patient type, and ethnicity). We matched the CIDR data with the dataset provided by the national Salmonella reference laboratory (NSRL) to which all Salmonella spp. isolates are referred for definitive typing. We calculated the main median time intervals in the flow of events of the notification process. Results In total, 416 laboratory confirmed Salmonella cases were captured by the national surveillance system and the NSRL and were included in the analysis. Completeness of non mandatory fields varied considerably. Organism was the most complete field (98.8%), ethnicity the least (11%). The median time interval between sample collection (first contact of the patient with the healthcare professional) to the first notification to the regional Department of Public Health (either a clinical or a laboratory notification) was 6 days (Interquartile 4-7 days). The median total identification time interval, time between sample collections to availability of serotyping and phage-typing results on the system was 25 days (Interquartile 19-32 days). Timeliness varied with respect to Salmonella species. Clinical notifications occurred more rapidly than laboratory notifications. Conclusions Further feedback and education should be given to health care professionals to improve completeness of reporting of non

  10. Implementation of guidelines on oxytocin use at caesarean section: a survey of practice in Great Britain and Ireland.

    LENUS (Irish Health Repository)

    Sheehan, Sharon R


    OBJECTIVE: Caesarean section is one of the most commonly performed major operations on women worldwide. Operative morbidity includes haemorrhage, anaemia, blood transfusion and in severe cases, maternal death. Various clinical guidelines address oxytocin use at the time of caesarean section. We previously reported wide variation in practice amongst clinicians in the United Kingdom in the use of oxytocin at caesarean section. The aim of this current study was to determine whether the variation in approach is universal across the individual countries of Great Britain and Ireland and whether this reflects differences in interpretation and implementation of clinical practice guidelines. STUDY DESIGN: We conducted a survey of practice in the five individual countries of Great Britain and Ireland. A postal questionnaire was sent to all lead consultant obstetricians and anaesthetists with responsibility for the labour ward. We explored the use of oxytocin bolus and infusion, the measurement of blood loss at caesarean section and the rates of major haemorrhage. Existing clinical guidelines from the National Institute for Clinical Excellence (NICE), the Royal College of Obstetricians and Gynaecologists (RCOG) and ALSO (Advanced Life Support in Obstetrics) were used to benchmark reported practice against recommended practice for the management of blood loss at caesarean section. RESULTS: The response rate was 82% (391 respondents). Use of a 5 IU oxytocin bolus was reported by 346 respondents (85-95% for individual countries). In some countries, up to 14% used a 10 IU oxytocin bolus despite recommendations against this. Routine use of an oxytocin infusion varied greatly between countries (11% lowest-55% highest). Marked variations in choice of oxytocin regimens were noted with inconsistencies in the country-specific recommendations, e.g. NICE (which covers England and Wales) recommends a 30 IU oxytocin infusion over 4h, but only 122 clinicians (40%) used this. CONCLUSIONS

  11. Anesthetic pharmacology

    National Research Council Canada - National Science Library

    Evers, Alex S; Maze, M; Kharasch, Evan D


    ...: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology...

  12. Nine-year comparison of presentation and management of acute coronary syndromes in Ireland: a national cross-sectional survey

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    Shelley Emer


    Full Text Available Abstract Background Shorter time to treatment is associated with lower mortality in acute coronary syndromes (ACS. A previous (1994 survey showed substantial delays for acute myocardial infarction (AMI in Ireland. The present study compared current practice with 1994 and surveyed acute coronary syndromes as a more complete contemporary evaluation of critical cardiac care than assessing AMI alone. Methods Following ethics committee approval, all centres (N = 39 admitting acute cardiac patients to intensive/coronary care unit provided information on 1365 episodes. A cross-sectional survey design was employed. Results Since 1994, median hospital arrival to thrombolysis time was reduced by 41% (76 to 45 minutes. Thrombolysis was delivered more often in the emergency department in 2003 (48% vs 2%. Thrombolysis when delivered in the emergency department was achieved faster than thrombolysis delivered in intensive/coronary care (35 mins v 60 mins; z = 5.62, p Conclusions Substantial improvements in time to thrombolysis have occurred since 1994, probably relating to treatment provision in emergency departments. Patient delay pre-hospital is still the principal impediment to effective treatment of ACS. A recent change of definition of AMI may have precluded an exact comparison between 1994 and 2003 data.

  13. What's up doc? A national cross-sectional study of psychological wellbeing of hospital doctors in Ireland. (United States)

    Hayes, Blánaid; Prihodova, Lucia; Walsh, Gillian; Doyle, Frank; Doherty, Sally


    To measure levels of psychological distress, psychological wellbeing and self-stigma in hospital doctors in Ireland. National cross-sectional study of randomised sample of hospital doctors. Participants provided sociodemographic data (age, sex, marital status), work grade (consultant, higher/basic specialist trainee), specialty and work hours and completed well-being questionnaires (the Depression Anxiety Stress Scale, WHO Well-being Index, General Health Questionnaire) and single-item scales on self-rated health and self-stigma. Irish publicly funded hospitals and residential institutions. 1749 doctors (response rate of 55%). All hospital specialties were represented except radiology. Half of participants were men (50.5%). Mean hours worked per week were 57 hours. Over half (52%) rated their health as very good/excellent, while 50.5% reported positive subjective well-being (WHO-5). Over a third (35%) experienced psychological distress (General Health Questionnaire 12). Severe/extremely severe symptoms of depression, anxiety and stress were evident in 7.2%, 6.1% and 9.5% of participants (Depression, Anxiety, Stress Scale 21). Symptoms of distress, depression, anxiety and stress were significantly higher and levels of well-being were significantly lower in trainees compared with consultants, and this was not accounted for by differences in sociodemographic variables. Self-stigma was present in 68.4%. The work hours of doctors working in Irish hospitals were in excess of European Working Time Directive's requirements. Just over half of hospital doctors in Ireland had positive well-being. Compared with international evidence, they had higher levels of psychological distress but slightly lower symptoms of depression and anxiety. Two-thirds of respondents reported self-stigma, which is likely to be a barrier to accessing care. These findings have implications for the design of support services for doctors, for discussions on quality of patient care and for future

  14. Children in hospital in Ireland - what do they eat and what do they weigh: a cross-sectional study

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    Flinn Aisling


    Full Text Available Abstract Background Overweight and obesity is a growing problem in Ireland. Many parents are unaware when their child is overweight or obese. Our objectives were to examine parents’ perceptions of a healthy diet and their children’s BMI; and to evaluate the food offered to children in our paediatric in-patient unit. Findings A retrospective questionnaire was distributed to 95 patients and their families admitted over one month. Seventy-eight had BMI values calculated (42 males, 36 females. Twenty-one children (26.9% were overweight/obese: 14/21 parents (66.7% thought their child had a normal weight. Sixty percent of children served dinner in the hospital were given fried potatoes. Four had fruit/vegetables. Forty-six parents brought food into hospital, of these 14 brought purchased food. Conclusions This study highlights the problem of child obesity in Ireland and parental underestimation of this problem. The nutritional value of food served to children in hospital needs to be improved and hospital admissions used as opportunities to promote healthy eating habits.

  15. Children in hospital in Ireland - what do they eat and what do they weigh: a cross-sectional study

    LENUS (Irish Health Repository)

    Flinn, Aisling


    AbstractBackgroundOverweight and obesity is a growing problem in Ireland. Many parents are unaware when their child is overweight or obese. Our objectives were to examine parents’ perceptions of a healthy diet and their children’s BMI; and to evaluate the food offered to children in our paediatric in-patient unit.FindingsA retrospective questionnaire was distributed to 95 patients and their families admitted over one month. Seventy-eight had BMI values calculated (42 males, 36 females). Twenty-one children (26.9%) were overweight\\/obese: 14\\/21 parents (66.7%) thought their child had a normal weight. Sixty percent of children served dinner in the hospital were given fried potatoes. Four had fruit\\/vegetables. Forty-six parents brought food into hospital, of these 14 brought purchased food.ConclusionsThis study highlights the problem of child obesity in Ireland and parental underestimation of this problem. The nutritional value of food served to children in hospital needs to be improved and hospital admissions used as opportunities to promote healthy eating habits.

  16. Health Care Utilisation by Bullying Victims: A Cross-Sectional Study of A 9-Year-Old Cohort in Ireland


    Catherine Hayes; Dervla Kelly; Cristina Taut; Elizabeth Nixon; Lina Zgaga; James Williams; Thomas O’Dowd; Udo Reulbach


    Children frequently refrain from disclosing being bullied. Early identification of bullying by healthcare professionals in children may prevent adverse health consequences. The aim of our study was to determine whether Health Care Utilisation (HCU) is higher in 9-year-olds who report being bullied and factors influencing type of HCU. The study consists of cross-sectional surveys of Child Cohort of Irish National Longitudinal Study of Children (Wave 1), 8,568 9-year-olds, and their carers. Bei...

  17. A Cross-Sectional Survey of Near-Infrared Spectroscopy Use in Pediatric Cardiac ICUs in the United Kingdom, Ireland, Italy, and Germany. (United States)

    Hoskote, Aparna U; Tume, Lyvonne N; Trieschmann, Uwe; Menzel, Christoph; Cogo, Paola; Brown, Katherine L; Broadhead, Michael W


    Despite the increasing use of near-infrared spectroscopy across pediatric cardiac ICUs, there is significant variability and equipoise with no universally accepted management algorithms. We aimed to explore the use of near-infrared spectroscopy in pediatric cardiac ICUs in the United Kingdom, Ireland, Italy, and Germany. A cross-sectional multicenter, multinational electronic survey of one consultant in each pediatric cardiac ICU. Pediatric cardiac ICUs in the United Kingdom and Ireland (n = 13), Italy (n = 12), and Germany (n = 33). Questionnaire targeted to establish use, targets, protocols/thresholds for intervention, and perceived usefulness of near-infrared spectroscopy monitoring. Overall, 42 of 58 pediatric cardiac ICUs (72%) responded: United Kingdom and Ireland, 11 of 13 (84.6%); Italy, 12 of 12 (100%); and Germany, 19 of 33 (57%, included all major centers). Near-infrared spectroscopy usage varied with 35% (15/42) reporting that near-infrared spectroscopy was not used at all (7/42) or occasionally (8/42); near-infrared spectroscopy use was much less common in the United Kingdom (46%) when compared with 78% in Germany and all (100%) in Italy. Only four units had a near-infrared spectroscopy protocol, and 18 specifically used near-infrared spectroscopy in high-risk patients; 37 respondents believed that near-infrared spectroscopy added value to standard monitoring and 23 believed that it gave an earlier indication of deterioration, but only 19 would respond based on near-infrared spectroscopy data alone. Targets for absolute values and critical thresholds for intervention varied widely between units. The reasons cited for not or occasionally using near-infrared spectroscopy were expense (n = 6), limited evidence and uncertainty on how it guides management (n = 4), difficulty in interpretation, and unreliability of data (n = 3). Amongst the regular or occasional near-infrared spectroscopy users (n = 35), 28 (66%) agreed that a multicenter study is warranted

  18. General practitioners' attitudes and preparedness towards Clinical Decision Support in e-Prescribing (CDS-eP adoption in the West of Ireland: a cross sectional study

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    O'Brien Timothy


    Full Text Available Abstract Background Electronic clinical decision support (CDS is increasingly establishing its role in evidence-based clinical practice. Considerable evidence supports its enhancement of efficiency in e-Prescribing, but some controversy remains. This study evaluated the practicality and identified the perceived benefits of, and barriers to, its future adoption in the West of Ireland. Methods This cross sectional study was carried out by means of a 27-part questionnaire sent to 262 registered general practitioners in Counties Galway, Mayo and Roscommon. The survey domains encompassed general information of individual's practice, current use of CDS and the practitioner's attitudes towards adoption of CDS-eP. Descriptive and inferential analyses were performed to analyse the data collected. Results The overall response rate was 37%. Nearly 92% of respondents employed electronic medical records in their practice. The majority acknowledged the value of electronic CDS in improving prescribing quality (71% and reducing prescribing errors (84%. Despite a high degree of unfamiliarity (73%, the practitioners were open to the use of CDS-eP (94% and willing to invest greater resources for its implementation (62%. Lack of a strategic implementation plan (78% is the main perceived barrier to the incorporation of CDS-eP into clinical practice, followed by i lack of financial incentives (70%, ii lack of standardized product software (61%, iii high sensitivity of drug-drug interaction or medication allergy markers (46%, iv concern about overriding physicians' prescribing decisions(44% and v lack of convincing evidence on the systems' effectiveness (22%. Conclusions Despite favourable attitudes towards the adoption of CDS-eP, multiple perceived barriers impede its incorporation into clinical practice. These merit further exploration, taking into consideration the structure of the Irish primary health care system, before CDS-eP can be recommended for routine

  19. Health Care Utilisation by Bullying Victims: A Cross-Sectional Study of A 9-Year-Old Cohort in Ireland. (United States)

    Hayes, Catherine; Kelly, Dervla; Taut, Cristina; Nixon, Elizabeth; Zgaga, Lina; Williams, James; O'Dowd, Thomas; Reulbach, Udo


    Children frequently refrain from disclosing being bullied. Early identification of bullying by healthcare professionals in children may prevent adverse health consequences. The aim of our study was to determine whether Health Care Utilisation (HCU) is higher in 9-year-olds who report being bullied and factors influencing type of HCU. The study consists of cross-sectional surveys of Child Cohort of Irish National Longitudinal Study of Children (Wave 1), 8,568 9-year-olds, and their carers. Being bullied was assessed by a self-reported questionnaire completed by children at home. HCU outcomes consisted of the following: visits to GP, Mental Health Practitioner (MHP), Emergency Department (ED), and nights in hospital by parent interview. Bivariate logistic regression and gender-stratified Poisson models were used to determine association. Victimisation by bullying independently increased visits to GP (OR 1.13, 95% confidence interval (CI): 1.03 to 1.25; p = 0.02), MHP (OR 1.31, 95% CI: 1.05 to 1.63; p = 0.02), though not ED visits (OR 0.99, 95% CI: 0.87 to 1.13; p = 0.8) or nights in hospital (OR 1.07 95% CI: 0.97 to 1.18; p = 0.2), adjusting for underlying chronic condition(s) and socio-demographic confounders. Victimised girls made higher GP visits (RR 1.14, 95% CI: 1.06 to 1.23; p according to gender and gender differences in the presentation of victimisation. Our findings may lead to the development of clinical practice guidelines for early detection and appropriate management of bullied children.

  20. Health Care Utilisation by Bullying Victims: A Cross-Sectional Study of A 9-Year-Old Cohort in Ireland

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    Catherine Hayes


    Full Text Available Children frequently refrain from disclosing being bullied. Early identification of bullying by healthcare professionals in children may prevent adverse health consequences. The aim of our study was to determine whether Health Care Utilisation (HCU is higher in 9-year-olds who report being bullied and factors influencing type of HCU. The study consists of cross-sectional surveys of Child Cohort of Irish National Longitudinal Study of Children (Wave 1, 8,568 9-year-olds, and their carers. Being bullied was assessed by a self-reported questionnaire completed by children at home. HCU outcomes consisted of the following: visits to GP, Mental Health Practitioner (MHP, Emergency Department (ED, and nights in hospital by parent interview. Bivariate logistic regression and gender-stratified Poisson models were used to determine association. Victimisation by bullying independently increased visits to GP (OR 1.13, 95% confidence interval (CI: 1.03 to 1.25; p = 0.02, MHP (OR 1.31, 95% CI: 1.05 to 1.63; p = 0.02, though not ED visits (OR 0.99, 95% CI: 0.87 to 1.13; p = 0.8 or nights in hospital (OR 1.07 95% CI: 0.97 to 1.18; p = 0.2, adjusting for underlying chronic condition(s and socio-demographic confounders. Victimised girls made higher GP visits (RR 1.14, 95% CI: 1.06 to 1.23; p < 0.001 and spent more nights in hospital (RR 1.10, 95% CI: 1.04 to 1.15; p < 0.001. Victimised boys were more likely to contact MHPs (RR 1.21, 95% CI: 1.02 to 1.44; p = 0.03. 9-year-old bullied subjects were more likely to utilise primary care services than non-bullied 9-year-olds. Different HCU patterns were observed according to gender and gender differences in the presentation of victimisation. Our findings may lead to the development of clinical practice guidelines for early detection and appropriate management of bullied children.

  1. Pattern of Frequent But Nontargeted Pharmacologic Thromboprophylaxis for Hospitalized Patients With Cancer at Academic Medical Centers: A Prospective, Cross-Sectional, Multicenter Study (United States)

    Zwicker, Jeffrey I.; Rojan, Adam; Campigotto, Federico; Rehman, Nadia; Funches, Renee; Connolly, Gregory; Webster, Jonathan; Aggarwal, Anita; Mobarek, Dalia; Faselis, Charles; Neuberg, Donna; Rickles, Frederick R.; Wun, Ted; Streiff, Michael B.; Khorana, Alok A.


    Purpose Hospitalized patients with cancer are considered to be at high risk for venous thromboembolism (VTE). Despite strong recommendations in numerous clinical practice guidelines, retrospective studies have shown that pharmacologic thromboprophylaxis is underutilized in hospitalized patients with cancer. Patients and Methods We conducted a prospective, cross-sectional study of hospitalized patients with cancer at five academic hospitals to determine prescription rates of thromboprophylaxis and factors influencing its use during hospitalization. Results A total of 775 patients with cancer were enrolled across five academic medical centers. Two hundred forty-seven patients (31.9%) had relative contraindications to pharmacologic prophylaxis. Accounting for contraindications to anticoagulation, the overall rate of pharmacologic thromboprophylaxis was 74.2% (95% CI, 70.4% to 78.0%; 392 of 528 patients). Among the patients with cancer without contraindications for anticoagulation, individuals hospitalized with nonhematologic malignancies were significantly more likely to receive pharmacologic thromboprophylaxis than those with hematologic malignancies (odds ratio [OR], 2.34; 95% CI, 1.43 to 3.82; P = .007). Patients with cancer admitted for cancer therapy were significantly less likely to receive pharmacologic thromboprophylaxis than those admitted for other reasons (OR, 0.37; 95% CI, 0.22 to 0.61; P < .001). Sixty-three percent of patients with cancer classified as low risk, as determined by the Padua Scoring System, received anticoagulant thromboprophylaxis. Among the 136 patients who did not receive anticoagulation, 58.8% were considered to be high risk by the Padua Scoring System. Conclusion We conclude that pharmacologic thromboprophylaxis is frequently administered to hospitalized patients with cancer but that nearly one third of patients are considered to have relative contraindications for prophylactic anticoagulation. Pharmacologic thromboprophylaxis in

  2. Cross-sectional Analysis of the Standards of Consent Applied to Anaesthesia in Ireland: Are Anaesthetists Aware of their Legal and Ethical Obligations?

    LENUS (Irish Health Repository)


    Consent to a medical intervention has legally and ethically evolved to a process prioritising autonomy and patient-led decision-making. This cross-sectional analysis investigated Irish anaesthetists’ practices of taking consent. Following ethical approval, trainees and fellows of the College of Anaesthetists of Ireland were invited to participate in a 33 question online survey. One hundred and sixty responses (11.8%) were received, an equal number coming from consultants and trainees. The majority (93.7%) worked in a teaching hospital. Fifteen percent said their department had guidelines on obtaining consent for anaesthesia, but only 4.5% said their department used a separate consent form. Most (63.8%) do not usually document consent. A significant number rarely (21.8%) or never (27.8%) explained risks to patients. Lack of time was identified as the most frequent barrier (77.6%), with just under half first meeting the patient in the theatre holding-bay or the anaesthetic room. Forty-one percent felt the ultimate decision regarding which anaesthetic technique is employed should usually lie with the anaesthetist alone. These results suggest a wide variation in the practice of obtaining consent for anaesthesia. Less than half deemed their practice to be adequate in this regard, while 50% were concerned about litigation stemming from inadequate consent.

  3. Online versus paper-based screening for depression and anxiety in adults with cystic fibrosis in Ireland: a cross-sectional exploratory study. (United States)

    Cronly, Jennifer; Duff, Alistair J; Riekert, Kristin A; Perry, Ivan J; Fitzgerald, Anthony P; Horgan, Aine; Lehane, Elaine; Howe, Barbara; Ni Chroinin, Muireann; Savage, Eileen


    To compare online and paper-based screening for depression and anxiety in adults with cystic fibrosis (CF). Cross-sectional study in CF clinics in Ireland and through the Cystic Fibrosis Ireland online community. 160 adult patients aged 18 or above were recruited. Of these, 147 were included in the analysis; 83 online and 64 paper-based. The remaining 13 were excluded because of incomplete data. Depression and anxiety were measured using the Hospital Anxiety and Depression Scale (HADS). Data on pulmonary function (forced expiratory volume in 1 s %) and body mass index were self-reported based on clinical assessments. Sociodemographic data were collected. Compared with the paper-based participants, the online participants were more likely to be female (61.7% vs 48.4%), older (mean 32.2 vs 28.2 years) and were more likely to be married (32.5% vs 15.6%), living with their spouse or partner (42.5% vs 22.6%) and working either full time (33.7% vs 15.9%) or part time (30.1%vs 17.5%). The prevalence rates of elevated anxiety and depression were not significantly different (P=0.71 and P=0.56). HADS anxiety and depression scores were not statistically different between online (P=0.83) and paper-based (P=0.92) participants based on Mann-Whitney U test. A significant negative correlation was found between depression and pulmonary function (r=-0.39, P=0.01) and anxiety and pulmonary function (r=-0.36, P=0.02). Based on Cronbach's alpha, there were no statistically significant differences between the online and paper-based participants on the internal consistency of the HADS anxiety (P=0.073) and depression (P=0.378) scales. Our findings suggest that online and paper-based screening for depression and anxiety in adult patients with CF yield comparable findings on prevalence rates and scores, associations with health and internal consistency of subscales. This study highlights that online screening offers an alternative method to paper-based screening. Further research with a

  4. Trends and interaction of polypharmacy and potentially inappropriate prescribing in primary care over 15 years in Ireland: a repeated cross-sectional study.

    LENUS (Irish Health Repository)

    Moriarty, Frank


    To examine: (1) changes in polypharmacy in 1997, 2002, 2007 and 2012 and; (2) changes in potentially inappropriate prescribing (PIP) prevalence and the relationship between PIP and polypharmacy in individuals aged ≥65 years over this period in Ireland.

  5. Are the special educational needs of children in their first year in primary school in Ireland being identified: a cross-sectional study. (United States)

    Curtin, Margaret; Baker, Denise; Staines, Anthony; Perry, Ivan J


    If the window of opportunity presented by the early years is missed, it becomes increasingly difficult to create a successful life-course. A biopsychosocial model of special educational need with an emphasis on participation and functioning moves the frame of reference from the clinic to the school and the focus from specific conditions to creating supportive environments cognisant of the needs of all children. However, evidence suggests that an emphasis on diagnosed conditions persists and that the needs of children who do not meet these criteria are not identified.The Early Development Instrument (EDI) is a well-validated, teacher-completed population-level measure of five domains of child development. It is uniquely placed, at the interface between health and education, to explore the developmental status of children with additional challenges within a typically developing population. The aim of this study was to examine the extent to which the special educational needs of children in their first year of formal education have been identified. This cross-sectional study was conducted in Ireland in 2011. EDI (teacher completed) scores were calculated for 1344 children. Data were also collected on special needs and on children identified by the teacher as needing assessment. Mean developmental scores were compared using one-way ANOVA. Eighty-three children in the sample population (6.2%) had identified special educational needs. A further 132 children were judged by the teacher as needing assessment. Children with special needs had lower mean scores than typically developing children, in all five developmental domains. Children considered by the teacher as needing assessment also had lower scores, which were not significantly different from those of children with special needs. Speech, emotional or behavioural difficulties were the most commonly reported problems among children needing further assessment. There was also a social gradient among this group. A small

  6. Frequency of Self-Reported Concussion Amongst Professional and Semi-Professional Footballers in Ireland During the 2014 Season: a Cross-Sectional Study. (United States)

    Coffey, Nicola; Lawless, Martin; Kelly, Seamus; Buggy, Conor


    This paper examines the occupational risk of concussion amongst professional and semi-professional footballers in Ireland during the 2014 League of Ireland season. As part of a broader nationally representative study examining occupational safety and health (OSH) awareness amongst professional footballers, this empirical quantitative study, utilising a convenience sample is the first and largest investigation of the frequency of, and attitudes towards, concussion and concussion reporting amongst Irish senior professional and semi-professional footballers. A census survey using an anonymous questionnaire was provided to available League of Ireland clubs between March and May 2015. Permission to access players was provided by the Professional Footballers Association of Ireland. This convenience sample was determined by club availability in relation to match fixtures. Participation by the footballers was voluntary. At the time, there were 250 professional and semi-professional players within the League available to participate. A total of 149 footballers participated in the study. Sixty percent of the participants were employed on a semi-professional basis and the majority of all participants were aged between 18 and 30. 15.7% of the participants reported having received a concussion in the 2014 season with semi-professional players having a noticeably higher (though not significant) reporting rate. Analysis indicated that there was a significant association between playing position and concussion reporting with defenders having the greater odds of reporting a concussion than other playing positions. Professional and semi-professional footballers have a relatively equal risk of receiving a concussion. This research is the first major investigation of the self-reported frequency of, and attitudes towards, concussion amongst Irish senior professional and semi-professional footballers. The results have important implications for coaches, clinicians, parents, players and

  7. Harriet Martineau and Ireland


    Conway, Brian; Hill, Michael R.


    The Victorian sociologist-novelist Harriet Martineau visited Ireland on two different occasions, first in 1832 and again, twenty years later, in 1852, just six years after the Great Famine of 1846, when the country was still very much visibly affected by that event. Her latter journey covered some 1,200 miles and encompassed all four provinces that make up the island of Ireland, north and south. Martineau was not the first foreign visitor to nineteenth century Ireland, of co...

  8. African Journals Online: Ireland

    African Journals Online (AJOL)

    African Journals Online: Ireland. Home > African Journals Online: Ireland. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register · Browse By Category · Browse Alphabetically · Browse By Country · List All Titles · Free to read Titles This Journal is Open Access. Afghanistan ...

  9. Cuisine Ireland 'APP'


    Seberry, Dermot


    Description Cuisine Ireland contains 15 samplerecipes from renowned Irish chef and author Dermot Seberry. Taking you to the heart of ancient Ireland, from the most northern beauty of the Mourne & Cooley peninsula along the magnificent east coastline and across to the Boyne Valley, the focus of this app is on the very best the region has to offer food tourists and local chefs. This app was developed as a companion piece to Dermot’s new book “Ireland, A Culinary Journey of the North East”. T...

  10. Ireland's Competitiveness Challenge 2011



    The NCC publishes two annual competitiveness reports. Ireland's Competitiveness Challenge focuses on the national competitiveness issues of most importance to the enterprise sector and identifies policy recommendations required to address these issues. The report focuses on pursuing policies to improve competitiveness, particularly those to reduce the cost base for enterprise, to enhance the performance of the entire education system, and to deliver meaningful public sector reform. Ireland's ...

  11. New Apprenticeships in Ireland


    Deegan, Mark


    Short Abstract: There are twenty-seven statutory Apprenticeships in Ireland. The Department of Education and Skills has a strategy to develop over a hundred new Apprenticeships. This paper addresses the steps being taken to develop these programmes and to encourage stakeholders to engage with Apprenticeship as a mode of education. Full Abstract: There are twenty-seven statutory Apprenticeships in Ireland. The Department of Education and Skills has a strategy to develop over a hundred...

  12. A cross-sectional study on the prevalence and risk factors for foot and limb lesions in piglets on commercial farms in Ireland


    Quinn, Amy Jean; Boyle, L. A.; Kilbride, A. L. (Amy L.); Green, Laura E.


    A cross-sectional survey of 68 integrated Irish pig farms was conducted to determine the prevalence and risk factors for foot and limb lesions in 2948 piglets from 272 litters. One litter was selected per age category; 3–7 days, 8–14 days, 15–21 days and 22–28 days per farm. All piglets were examined for sole bruising, sole erosion, coronary band injuries, limb abrasions, alopecia, swollen limbs and swollen feet and scored from 0 to 3 based on relative size. Environmental parameters were reco...

  13. Northern Ireland gas industry

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, R S [Belfast City Council Gas Dept.; Asquith, R S; Brown, J M; McKay, G


    Throughout Northern Ireland the production of town gas is derived from hydrocarbon feedstocks. In the larger undertakings in Northern Ireland the feedstock is light distillate; a light petroleum feedstock which is a crude gasoline comprised mainly of pentanes, reformed in catalytic plants. The remaining gas undertakings produce a liquefied petroleum gas (LPG)/air mixture using a mixture of either butane or propane and air. The individual gas units and the type of reforming feedstock are shown. A review of the oil-dependence of town gas and electricity production in Northern Ireland has been considered and is mainly responsible for the high fuel prices experienced in the community. A detailed description of the reforming process has been described, and considerable efforts have been made to optimize the process. In spite of substantial economic savings being made on the processing unit, the gas industry is very susceptible to the changes in oil prices which have escalated rapidly in recent years. The difference in gas prices between the United Kingdom and Northern Ireland indicates that North Sea gas would offer major economic benefits to the gas industry in Northern Ireland, which is operating at a substantial loss at the moment. The industrial concerns, which are dependent on gas and therefore paying high fuel costs, suffer in competition with outside companies. The injection of a moderately cheap natural gas supply to the community may encourage industrial expansion and provide work in a high unemployment area. Although substantial costs must be incurred in distribution pipelines and burner conversions if Northern Ireland changes to natural gas, there appears to be a strong case to introduce North Sea gas in the near future.

  14. [Primary care in Ireland]. (United States)

    Sánchez-Sagrado, T

    Spanish doctors are still leaving the country to look for quality work. Ireland is not a country with many Spanish professionals but it is interesting to know its particular Health care system. Ireland is one of the countries with a national health care system, although it has a mixture of private health care insurance schemes. People have a right to health care if they have been living in Ireland at least for a year. Access to the primary care health system depends on age and income: free of charge for Category 1 and co-payments for the rest. This division generates great inequalities among the population. Primary Care doctors are self-employed, and they work independently. However, since 2001 they have tended to work in multidisciplinary teams in order to strengthen the Primary Care practice. Salary is gained from a combination of public and private incomes which are not differentiated. The role of the General Practitioner consists in the treatment of acute and chronic diseases, minor surgery, child care, etc. There is no coordination between Primary and Secondary care. Access to specialised medicine is regulated by the price of consultation. Primary Care doctors are not gatekeepers. To be able to work here, doctors must have three years of training after medical school. After that, Continuing Medical Education is compulsory, and the college of general practitioners monitors it annually. The Irish health care system does not fit into the European model. Lack of a clear separation between public and private health care generates great inequalities. The non-existence of coordination between primary and specialised care leads to inefficiencies, which Ireland cannot allow itself after a decade of economic crisis. Copyright © 2017 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España, S.L.U. All rights reserved.

  15. [Pharmacological treatment]. (United States)

    Arriola Manchola, Enrique; Álaba Trueba, Javier


    Alzheimer's disease (AD) is a chronic degenerative and inflammatory process leading to synapticdysfunction and neuronal death. A review about the pharmacological treatment alternatives is made: acetylcholinesterase inhibitors (AChEI), a nutritional supplement (Souvenaid) and Ginkgo biloba. A special emphasis on Ginkgo biloba due to the controversy about its use and the approval by the European Medicines Agency is made. Copyright © 2016 Sociedad Española de Geriatría y Gerontología. Publicado por Elsevier España, S.L.U. All rights reserved.

  16. Pharmacology and Therapeutics Education in the European Union Needs Harmonization and Modernization: A Cross-sectional Survey Among 185 Medical Schools in 27 Countries. (United States)

    Brinkman, D J; Tichelaar, J; Okorie, M; Bissell, L; Christiaens, T; Likic, R; Mačìulaitis, R; Costa, J; Sanz, E J; Tamba, B I; Maxwell, S R; Richir, M C; van Agtmael, M A


    Effective teaching in pharmacology and clinical pharmacology and therapeutics (CPT) is necessary to make medical students competent prescribers. However, the current structure, delivery, and assessment of CPT education in the European Union (EU) is unknown. We sent an online questionnaire to teachers with overall responsibility for CPT education in EU medical schools. Questions focused on undergraduate teaching and assessment of CPT, and students' preparedness for prescribing. In all, 185 medical schools (64%) from 27 EU countries responded. Traditional learning methods were mainly used. The majority of respondents did not provide students with the opportunity to practice real-life prescribing and believed that their students were not well prepared for prescribing. There is a marked difference in the quality and quantity of CPT education within and between EU countries, suggesting that there is considerable scope for improvement. A collaborative approach should be adopted to harmonize and modernize the undergraduate CPT education across the EU. © 2017 The Authors Clinical Pharmacology & Therapeutics published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.

  17. PREFACE: Kelvin and Ireland (United States)

    Flood, Raymond; McCartney, Mark; Whitaker, Andrew


    Sir Joseph Larmor unveiling the Kelvin memorial in the Botanic Gardens, Belfast on a rainy day in 1913 Sir Joseph Larmor unveiling the Kelvin memorial in the Botanic Gardens, Belfast on a rainy day in 1913 © The Ulster Museum: Hogg collection William Thomson, later Lord Kelvin, was born in Belfast in 1824, and his family had lived near Ballynahinch in the north of Ireland, quite close to Belfast, from the seventeenth century. At the time of Kelvin's birth, James Thomson, his father, was Professor of Mathematics at the Belfast Royal Academical Institution (Inst). However, following the death of his wife in 1830, James took up a new position as Professor at the University of Glasgow, and he and his children moved there in 1832. Apart from three years studying at Cambridge, and a very brief period immediately afterwards travelling and teaching in Cambridge, Kelvin was to spend the rest of his life in Glasgow, where he occupied the Chair of Natural Philosophy (or Physics) for 53 years. The natural assumption might be that his birth in Ireland was irrelevant to Kelvin's life and work, and that the fine monument erected in his honour in Belfast's Botanic Gardens, which is pictured on the front cover of this volume, was more a demonstration of civic pride than a recognition of an aspect of Kelvin's life which was important to him. The purpose of the meeting was to demon strate that this was not the case, that, great Glaswegian as he undoubtedly became, Kelvin always delighted in the title of Irishman. The influence of his father, very much an Ulsterman, was immense, and Kelvin and his siblings were to follow his non-sectarian and reforming approach. Also important for Kelvin was his Christian upbringing, which began in Belfast, and his beliefs were to play a role of importance in his life and indeed in much of his most important work, in particular that on thermodynamics. Two of his siblings returned to Belfast and spent much of their lives there, and Kelvin was a

  18. Iodine intake in Ireland

    International Nuclear Information System (INIS)

    Smith, P.P.A.; Hetherton, A.M.; O'Carroll, D.; Smith, D.F.; O'Halloran, M.J.; O'Donovan, D.K.


    A study of urinary iodine excretion and thyroid gland uptake of radioactive iodine 131 I was undertaken in the Dublin area with a view to providing data on the current iodine status in Ireland. A mean urinary iodine excretion of 118±82μg/gram creatinine (Median 96) obtained from 821 subjects attending general hospital outpatient clinics in the Dublin area in 1987, while excluding severe iodine deficiency in this particular cohort, obscured the fact that 250 (30%) had iodine excretion values ≤70 μ/g creatinine, a value approximating to the minimum daily iodine requirement. The results provide sufficient evidence of sporadic iodine deficiency to justify a more widespread study of the iodine status of the Irish population with a view to making recommendations on the possible need for iodine prophylaxis

  19. Space Pharmacology

    CERN Document Server

    Wotring, Virginia E


    “Space Pharmacology” is a review of the current knowledge regarding the use of pharmaceuticals during spaceflights. It is a comprehensive review of the literature, addressing each area of pharmacokinetics and each major physiological system in turn. Every section begins with a topic overview, and is followed by a discussion of published data from spaceflight, and from ground experiments meant to model the spaceflight situation. Includes a discussion looking forward to the new medical challenges we are likely to face on longer duration exploration missions. This book is a snapshot of our current knowledge that also highlights areas of unknown.

  20. Ireland unveils petroleum tax measures

    International Nuclear Information System (INIS)



    This paper reports that Ireland's government has introduced detailed petroleum tax legislation designed to boost offshore exploration and development. The petroleum tax measures, published last week and included in the government's omnibus finance bill for 1992, will provide Ireland for the first time a comprehensive petroleum tax regime. They include elements which, in tax terms, will make Ireland a most attractive location for oil and gas exploration and development, the Irish Energy Minister Robert Molloy. He the, Exploration companies will now have the benefit of the certainty of a detailed tax framework and attractive tax rates. Debate on the finance bill has begun in the Irish Dail (parliament). Under Ireland's constitution, the budget bill must be approved and signed by the president by the end of May. Failure to approve a budget bill within that time would mean the current government's collapse

  1. Introducing LIR (Lithotheque Ireland, a reference collection of flaked stone tool raw materials from Ireland

    Directory of Open Access Journals (Sweden)

    Killian Driscoll


    Full Text Available The LIR (Lithotheque Ireland reference collection of flaked stone tool raw materials from Ireland began in 2013, and is based on the geological prospection from two projects. The first (2013-2015 focused attention primarily on Carboniferous cherts from the northwest of Ireland, collecting 405 samples. The second (2015-2017 is currently collecting samples of the Cretaceous flint primarily from in situ contexts in the northeast of Ireland, but also includes beach surveys of Cretaceous flint from around the island; the first phase of geological prospection in Autumn 2015 collected 239 samples, with the geological prospection continuing in 2016. Therefore, to date the collection contains over 600 hand samples of chert and flint, along with a small number of other materials (siliceous limestone, tuff, mudstone. The physical reference collection is housed at the UCD School of Archaeology, University College Dublin and contains the geological hand samples along with the various thin sections of the samples that are used for petrographic analysis. The physical collection is complemented by an online database that is to be used alongside the physical collection, or can be used as a stand-alone resource. This paper provides an overview of the database’s metadata and the processes of data entry and editing, to serve as a reference point for the database and the fieldwork undertaken to date, and to serve as a template for other researchers undertaking similar work on lithic reference collections.

  2. Restitution from public authorities in Ireland


    Cleary, Niamh


    This thesis examines the law of restitution from public authorities in Ireland. It operates on two levels. First, it is the first large scale research project on the law of restitution in Ireland. It also analyses the law of restitution in Ireland and considers how Ireland has integrated traditional principles of restitution that have been developed in other common law jurisdictions. Second, it examines the law of restitution as it applies to public authorities in Ireland. It considers the re...

  3. Kelvin and industry in Ireland (United States)

    Crossland, Bernard; Whitaker, Andrew


    Kelvin was a great mathematician, theoretical and experimental physicist, and educator, founding the first physical laboratory. He worked tirelessly for the creation of a reproducible set of physical units, and he was also an experienced and enthusiastic sailor. All these talents were linked to his extensive technological work, of which the most important examples were the laying of the Atlantic cable, and the marine compass. In Ireland his most important contributions were the occulting nature of the Holywood lighthouse, and his connection with the Giant's Causeway tramway. Kelvin's work on cabling and national maritime projects may have stimulated his later strong support of the British Empire and opposition to Home Rule in Ireland.

  4. Using the ICF in Ireland.

    LENUS (Irish Health Repository)

    Good, Anne


    This paper reflects on the use of ICF in Ireland, taking as a case study the experience of the first National Disability Survey (NDS). There were four clear effects in Ireland of using ICF as a framework for the NDS: a) that a broader range of people with disabilities was encompassed; b) that the environmental factors included from the ICF were comprehensive and policy relevant; c) that both barriers and facilitators were incorporated into the model; and d) that a focus on research ethics was encouraged. Some general conclusions regarding the benefits and limitations of ICF based on this experience are also drawn.

  5. Kelvin and industry in Ireland

    International Nuclear Information System (INIS)

    Crossland, Bernard; Whitaker, Andrew


    Kelvin was a great mathematician, theoretical and experimental physicist, and educator, founding the first physical laboratory. He worked tirelessly for the creation of a reproducible set of physical units, and he was also an experienced and enthusiastic sailor. All these talents were linked to his extensive technological work, of which the most important examples were the laying of the Atlantic cable, and the marine compass. In Ireland his most important contributions were the occulting nature of the Holywood lighthouse, and his connection with the Giant's Causeway tramway. Kelvin's work on cabling and national maritime projects may have stimulated his later strong support of the British Empire and opposition to Home Rule in Ireland.

  6. Kelvin and industry in Ireland

    Energy Technology Data Exchange (ETDEWEB)

    Crossland, Bernard [Department of Mechanical Engineering, Queen' s University, Belfast BT7 1NN, Northern Ireland (United Kingdom); Whitaker, Andrew, E-mail:, E-mail: [Department of Physics, Queen' s University, Belfast BT7 1NN, Northern Ireland (United Kingdom)


    Kelvin was a great mathematician, theoretical and experimental physicist, and educator, founding the first physical laboratory. He worked tirelessly for the creation of a reproducible set of physical units, and he was also an experienced and enthusiastic sailor. All these talents were linked to his extensive technological work, of which the most important examples were the laying of the Atlantic cable, and the marine compass. In Ireland his most important contributions were the occulting nature of the Holywood lighthouse, and his connection with the Giant's Causeway tramway. Kelvin's work on cabling and national maritime projects may have stimulated his later strong support of the British Empire and opposition to Home Rule in Ireland.

  7. Burnout among Accounting and Finance Academics in Ireland (United States)

    Byrne, Marann; Chughtai, Aamir; Flood, Barbara; Murphy, Evelyn; Willis, Pauline


    Purpose: The purpose of this paper is to assess the levels of burnout experienced by accounting and finance academics in Ireland. Design/methodology/approach: Data for this cross-sectional survey study were collected from 100 accounting and finance academics teaching in Irish third level institutions. Independent sample "t"-tests, one…

  8. Biological and Pharmacological properties

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Biological and Pharmacological properties. NOEA inhibits Ceramidase. Anandamide inhibits gap junction conductance and reduces sperm fertilizing capacity. Endogenous ligands for Cannabinoid receptors (anandamide and NPEA). Antibacterial and antiviral ...

  9. Ethnopharmacology in Ireland: an overview

    Directory of Open Access Journals (Sweden)

    Yvonne Coady

    Full Text Available The aim of this review was to extract information of the book Medicinal Plants in Folk Tradition: An Ethnobotany of Britain & Ireland published in 2004 by Allen and Hatfield, to give an overview of plants with medicinal potential and their applications. This study attempts to attest, observe and comment on the diversity of plants, as well as the accompanying information which inevitably is vital for the future development of herbal medicines for human therapy. Initially, the information in relation to medicinal plants in Ireland only was extracted from the above-mentioned book and organised in tables. Afterwards, it was analysed through the construction of maps and the positioning of each piece of information in specific geographical regions of the country. Its division into provinces was taken into consideration as well as into counties within the provinces. These maps and graphs illustrate the most predominantly reported botanical families identified and utilised (Asteraceae, Scrophulariaceae and Lamiaceae, and to the most frequently cited medicinal uses were attributed to topical applications. As a result we can see that the uses of traditional medicines vary among these different geographical areas of the country. Not only different uses were reported but also different plants used to treat the same condition, or different conditions treated with the same plant depending on the county. Various phytopharmaceuticals date back several decades and despite the existing evolving technology, without a doubt herbal medicines can and still do provide exceptional and efficacious outcomes like many of the conventional remedies available today.

  10. What would encourage blood donation in Ireland? (United States)

    Harrington, M; Sweeney, M R; Bailie, K; Morris, K; Kennedy, A; Boilson, A; O'Riordan, J; Staines, A


    Recent changes have resulted in the loss of 4% of the donor panel in the Republic of Ireland and 3% in Northern Ireland. In order to increase the number of donors in these two regions, it is important that transfusion service providers explore and understand the reasons, which prevent individuals from donating. The aim of this study was to explore these issues particularly in non-donors and those who had lapsed. This 7-month all-Ireland study was conducted by computer-assisted telephone interview. Data collected included sociodemographic history, donation status, as well as barriers/deterrents to donation. There were 4166 completed questionnaires (44% donors; 56% non-donors). Of the donors, 13% had donated blood within the last 2 years. Current donors cited 'awareness of patients needs' (88%), 'trust in the blood transfusion service' (70%), and 'an advertising campaign' (70%) as reasons encouraging them to donate blood. Lapsed donors and non-donors cited 'more frequent mobile clinics/sessions' (30% lapsed donors; 53% non-donors), 'if I was asked' (28% lapsed donors; 53% non-donors), and 'more flexible opening hours' (23% lapsed donors; 44% non-donors) as reasons that would encourage them to donate. The main reasons cited by non-donors for never having donated included 'medical reasons' (41% Republic of Ireland; 43% Northern Ireland), 'lack of information' (20% Republic of Ireland; 22% Northern Ireland), 'fear of needles' (15% Republic of Ireland; 17% Northern Ireland), and 'time constraints' (12% Republic of Ireland; 13% Northern Ireland). Among the non-donor group, 10% (Republic of Ireland) and 6% (Northern Ireland) claimed that they are not permitted to donate. Replacing regular donors is a major challenge for the transfusion service providers. This study shows that by facilitating the general public by introducing more mobile clinics/sessions, more flexible opening hours and having a better level of knowledge in the community about blood donation may encourage

  11. A Survey entrepreneurship in Ireland 2016.


    Fitzsimons, Paula; O'Gorman, Colm


    A survey of entrepreneurship in Ireland, using the Global Entrepreneurship Monitor data. Data is collected from a representative sample of 2,000 adults. Key findings include that Ireland had relatively high rates of entrepreneurship in 2016, as measured by the TEA index. The levels of entrepreneurship in Ireland have now returned to the levels observed pre-recession. In many developed European economies, such as France, Germany, Spain and Sweden rates of entrepreneurship are much lower tha...

  12. Simulating Climate Change in Ireland (United States)

    Nolan, P.; Lynch, P.


    At the Meteorology & Climate Centre at University College Dublin, we are using the CLM-Community's COSMO-CLM Regional Climate Model (RCM) and the WRF RCM (developed at NCAR) to simulate the climate of Ireland at high spatial resolution. To address the issue of model uncertainty, a Multi-Model Ensemble (MME) approach is used. The ensemble method uses different RCMs, driven by several Global Climate Models (GCMs), to simulate climate change. Through the MME approach, the uncertainty in the RCM projections is quantified, enabling us to estimate the probability density function of predicted changes, and providing a measure of confidence in the predictions. The RCMs were validated by performing a 20-year simulation of the Irish climate (1981-2000), driven by ECMWF ERA-40 global re-analysis data, and comparing the output to observations. Results confirm that the output of the RCMs exhibit reasonable and realistic features as documented in the historical data record. Projections for the future Irish climate were generated by downscaling the Max Planck Institute's ECHAM5 GCM, the UK Met Office HadGEM2-ES GCM and the CGCM3.1 GCM from the Canadian Centre for Climate Modelling. Simulations were run for a reference period 1961-2000 and future period 2021-2060. The future climate was simulated using the A1B, A2, B1, RCP 4.5 & RCP 8.5 greenhouse gas emission scenarios. Results for the downscaled simulations show a substantial overall increase in precipitation and wind speed for the future winter months and a decrease during the summer months. The predicted annual change in temperature is approximately 1.1°C over Ireland. To date, all RCM projections are in general agreement, thus increasing our confidence in the robustness of the results.

  13. Patterns of psychotropic prescribing and polypharmacy in older hospitalized patients in Ireland: the influence of dementia on prescribing.

    LENUS (Irish Health Repository)

    Walsh, Kieran Anthony


    Neuropsychiatric Symptoms (NPS) are ubiquitous in dementia and are often treated pharmacologically. The objectives of this study were to describe the use of psychotropic, anti-cholinergic, and deliriogenic medications and to identify the prevalence of polypharmacy and psychotropic polypharmacy, among older hospitalized patients in Ireland, with and without dementia.

  14. Project Plan IRRS Ireland 2015

    International Nuclear Information System (INIS)

    Ryan, T.


    The IAEA Integrated Regulatory Review Service, IRRS was established to strengthen and enhance the effectiveness of national regulatory infrastructure for nuclear safety, radiation safety, radioactive waste and transport safety, and the security of radioactive sources, while recognising the ultimate responsibility of each Member State to ensure safety in these areas. The IRRS process sets out to accomplish this expressed purpose through consideration of both technical and policy issues of a regulatory nature against IAEA safety standards and, where appropriate, good practice elsewhere. The regulatory review process directly draws upon the wide-ranging international experience and expertise of IRRS review team members. Peer exchange on technical and policy issues gives insight into the efficiency and effectiveness of the legal and governmental framework and regulatory infrastructure for safety. Through this process, opportunities for improvement are explored and potential improvement strategies identified which may be shared with other States. IRRS missions provide an opportunity for sharing regulatory experiences, harmonising regulatory approaches among States, and creating mutual learning opportunities among regulators. IRRS discussions focus on issues arising from the State's self-assessment and the evaluation of technical areas and policy issues. There are binding legal requirements in both the Euratom Nuclear Safety and Radioactive Waste Directives that the national regulatory framework, including the regulatory body, is subject to a periodic international peer review. In practice these peer reviews are organised by the IAEA through an agreement with the EU and comprise a detailed examination of national provisions against the IAEA's Safety Standards. Ireland applied for its peer review mission on the 28th September 2010 and in an exchange of letters, 2015 was agreed between the IAEA and Ireland with a follow up mission foreseen for 2018 Appendix 1

  15. PPO.02 Severe maternal morbidity in Ireland

    NARCIS (Netherlands)

    Manning, E.; Lutomski, J.E.; O'Connor, L.; Corcoran, P.; Greene, R.


    OBJECTIVE: To assess the incidence of severe maternal morbidity (SMM) and examine associated factors in Ireland. METHODS: In 2011, 67,806 maternities were reported from 19 maternity units, representing 93% of maternities in Ireland. SMM was classified as the presence of one or more of 15 categories

  16. Cyber-Bullying: The Situation in Ireland (United States)

    O'Moore, Mona


    This paper reports on the first major survey of cyber-bullying undertaken in Ireland. While preliminary results have been published they were based on a smaller and incomplete sample of 12-16 year olds living in Ireland. The preliminary results addressed the incidence level of cyber-bullying and that of the different subcategories of…

  17. The Future of Renewable Gas in Ireland

    International Nuclear Information System (INIS)


    An outline is given how grass and waste can be converted into natural gas and can then be used locally or piped into the national grid for distribution around Ireland. The report estimates that 7.5% of Ireland's natural gas demand could be met by renewable gas, the equivalent of heating 300,000 homes each year.


    Directory of Open Access Journals (Sweden)

    I. V. Soldatenko


    Full Text Available Clinical pharmacology of diuretics in the international system of ATC (anatomic-therapeutic-chemical is presented. Classification of this group by the action mechanism and caused effects is provided. Pharmacokinetics and pharmacodynamics features, indications and principles of diuretics usage in clinics are considered. Contraindications, side effects and interaction with other drugs of this group are discussed in detail.

  19. Developmental paediatric anaesthetic pharmacology

    DEFF Research Database (Denmark)

    Hansen, Tom Giedsing


    Safe and effective drug therapy in neonates, infants and children require detailed knowledge about the ontogeny of drug disposition and action as well how these interact with genetics and co-morbidity of children. Recent advances in developmental pharmacology in children follow the increased...

  20. Pharmacological management of panic disorder

    Directory of Open Access Journals (Sweden)

    Carlo Marchesi


    Full Text Available Carlo MarchesiPsychiatric Section, Department of Neuroscience, University of Parma, Parma, ItalyAbstract: Panic disorder (PD is a disabling condition which appears in late adolescence or early adulthood and affects more frequently women than men. PD is frequently characterized by recurrences and sometimes by a chronic course and, therefore, most patients require longterm treatments to achieve remission, to prevent relapse and to reduce the risks associated with comorbidity. Pharmacotherapy is one of the most effective treatments of PD. In this paper, the pharmacological management of PD is reviewed. Many questions about this effective treatment need to be answered by the clinician and discussed with the patients to improve her/his collaboration to the treatment plan: which is the drug of choice; when does the drug become active; which is the effective dose; how to manage the side effects; how to manage nonresponse; and how long does the treatment last. Moreover, the clinical use of medication in women during pregnancy and breastfeeding or in children and adolescents was reviewed and its risk-benefit balance discussed.Keywords: panic disorder, pharmacological treatment, treatment guidelines

  1. Pharmacological interactions of vasoconstrictors. (United States)

    Gómez-Moreno, Gerardo; Guardia, Javier; Cutando, Antonio; Calvo-Guirado, José Luis


    This article is the first of a series on pharmacological interactions involving medicaments commonly prescribed and/or used in odontology: vasoconstrictors in local anaesthetics and anti-inflammatory and anti-microbial analgesics. The necessity for the odontologist to be aware of adverse reactions as a result of the pharmacological interactions is due to the increase in medicament consumption by the general population. There is a demographic change with greater life expectancy and patients have increased chronic health problems and therefore have increased medicament intake. The presence of adrenaline (epinephrine) and other vasoconstrictors in local odontological anaesthetics is beneficial in relation to the duration and depth of anaesthesia and reduces bleeding and systemic toxicity of the local anaesthetic. However, it might produce pharmacological interactions between the injected vasoconstrictors and the local anaesthetic and adrenergic medicament administered exogenically which the odontologist should be aware of, especially because of the risk of consequent adverse reactions. Therefore the importance of conducting a detailed clinical history of the general state of health and include all medicaments, legal as well as illegal, taken by the patient.

  2. Pharmacological effects of biotin. (United States)

    Fernandez-Mejia, Cristina


    In the last few decades, more vitamin-mediated effects have been discovered at the level of gene expression. Increasing knowledge on the molecular mechanisms of these vitamins has opened new perspectives that form a connection between nutritional signals and the development of new therapeutic agents. Besides its role as a carboxylase prosthetic group, biotin regulates gene expression and has a wide repertoire of effects on systemic processes. The vitamin regulates genes that are critical in the regulation of intermediary metabolism: Biotin has stimulatory effects on genes whose action favors hypoglycemia (insulin, insulin receptor, pancreatic and hepatic glucokinase); on the contrary, biotin decreases the expression of hepatic phosphoenolpyruvate carboxykinase, a key gluconeogenic enzyme that stimulates glucose production by the liver. The findings that biotin regulates the expression of genes that are critical in the regulation of intermediary metabolism are in agreement with several observations that indicate that biotin supply is involved in glucose and lipid homeostasis. Biotin deficiency has been linked to impaired glucose tolerance and decreased utilization of glucose. On the other hand, the diabetic state appears to be ameliorated by pharmacological doses of biotin. Likewise, pharmacological doses of biotin appear to decrease plasma lipid concentrations and modify lipid metabolism. The effects of biotin on carbohydrate metabolism and the lack of toxic effects of the vitamin at pharmacological doses suggest that biotin could be used in the development of new therapeutics in the treatment of hyperglycemia and hyperlipidemia, an area that we are actively investigating.

  3. Carotenoids: biochemistry, pharmacology and treatment. (United States)

    Milani, Alireza; Basirnejad, Marzieh; Shahbazi, Sepideh; Bolhassani, Azam


    Carotenoids and retinoids have several similar biological activities such as antioxidant properties, the inhibition of malignant tumour growth and the induction of apoptosis. Supplementation with carotenoids can affect cell growth and modulate gene expression and immune responses. Epidemiological studies have shown a correlation between a high carotenoid intake in the diet with a reduced risk of breast, cervical, ovarian, colorectal cancers, and cardiovascular and eye diseases. Cancer chemoprevention by dietary carotenoids involves several mechanisms, including effects on gap junctional intercellular communication, growth factor signalling, cell cycle progression, differentiation-related proteins, retinoid-like receptors, antioxidant response element, nuclear receptors, AP-1 transcriptional complex, the Wnt/β-catenin pathway and inflammatory cytokines. Moreover, carotenoids can stimulate the proliferation of B- and T-lymphocytes, the activity of macrophages and cytotoxic T-cells, effector T-cell function and the production of cytokines. Recently, the beneficial effects of carotenoid-rich vegetables and fruits in health and in decreasing the risk of certain diseases has been attributed to the major carotenoids, β-carotene, lycopene, lutein, zeaxanthin, crocin (/crocetin) and curcumin, due to their antioxidant effects. It is thought that carotenoids act in a time- and dose-dependent manner. In this review, we briefly describe the biological and immunological activities of the main carotenoids used for the treatment of various diseases and their possible mechanisms of action. This article is part of a themed section on Principles of Pharmacological Research of Nutraceuticals. To view the other articles in this section visit © 2016 The British Pharmacological Society.

  4. Energy in Ireland: context, management and research

    International Nuclear Information System (INIS)

    Saintherant, N.; Lerouge, Ch.; Welcker, A.


    In the framework of the climatic change and the fossil fuels shortage, the Ireland defined a new energy policy. The priority is the energy supply security and the research programs present a great interest in the ocean energies, which represent an important source in Ireland. The report presents the context, the irish energy policy, the research programs on energy and the different actors of the domain. (A.L.B.)

  5. Pharmacological Profile of Quinoxalinone

    Directory of Open Access Journals (Sweden)

    Youssef Ramli


    Full Text Available Quinoxalinone and its derivatives are used in organic synthesis for building natural and designed synthetic compounds and they have been frequently utilized as suitable skeletons for the design of biologically active compound. This review covers updated information on the most active quinoxalinone derivatives that have been reported to show considerable pharmacological actions such as antimicrobial, anti-inflammatory, antidiabetic, antiviral, antitumor, and antitubercular activity. It can act as an important tool for chemists to develop newer quinoxalinone derivatives that may prove to be better agents in terms of efficacy and safety.

  6. Cyberbullying, Schools and the Law: A Comparative Study in Northern Ireland and the Republic of Ireland (United States)

    Purdy, Noel; Mc Guckin, Conor


    Background: This study addresses the fast developing behavioural issue of cyberbullying in schools and its complex legal context. Purpose: This study set out to investigate teachers' perceptions of the extent of cyberbullying and the extent to which school leaders in Northern Ireland and the Republic of Ireland feel knowledgeable and confident…

  7. Renewable Energy Policy Fact sheet - Ireland

    International Nuclear Information System (INIS)


    The EurObserv'ER policy profiles give a snapshot of the renewable energy policy in the EU Member States. With Ireland's current 'trajectory' of renewable energy growth, it is likely to slightly fall short of its 2020 nationally binding renewable energy target. Ireland initiated a 'moratorium' on its REFIT (Renewable Energy Feed-in Tariff) support scheme in December 2015, with the aim of introducing a revised scheme in 2017 in line with market developments. Grants and tax relief remain in place for renewable heat promotion. An Offshore Renewable Energy Development Plan (OREDP) was introduced in 2014, which sets out Government policy in relation to the sustainable development of Ireland's abundant offshore renewable energy resource

  8. Pharmacological therapy for amblyopia

    Directory of Open Access Journals (Sweden)

    Anupam Singh


    Full Text Available Amblyopia is the most common cause of preventable blindness in children and young adults. Most of the amblyopic visual loss is reversible if detected and treated at appropriate time. It affects 1.0 to 5.0% of the general population. Various treatment modalities have been tried like refractive correction, patching (both full time and part time, penalization and pharmacological therapy. Refractive correction alone improves visual acuity in one third of patients with anisometropic amblyopia. Various drugs have also been tried of which carbidopa & levodopa have been popular. Most of these agents are still in experimental stage, though levodopa-carbidopa combination therapy has been widely studied in human amblyopes with good outcomes. Levodopa therapy may be considered in cases with residual amblyopia, although occlusion therapy remains the initial treatment choice. Regression of effect after stoppage of therapy remains a concern. Further studies are therefore needed to evaluate the full efficacy and side effect profile of these agents.

  9. Pharmacological therapy for amblyopia (United States)

    Singh, Anupam; Nagpal, Ritu; Mittal, Sanjeev Kumar; Bahuguna, Chirag; Kumar, Prashant


    Amblyopia is the most common cause of preventable blindness in children and young adults. Most of the amblyopic visual loss is reversible if detected and treated at appropriate time. It affects 1.0 to 5.0% of the general population. Various treatment modalities have been tried like refractive correction, patching (both full time and part time), penalization and pharmacological therapy. Refractive correction alone improves visual acuity in one third of patients with anisometropic amblyopia. Various drugs have also been tried of which carbidopa & levodopa have been popular. Most of these agents are still in experimental stage, though levodopa-carbidopa combination therapy has been widely studied in human amblyopes with good outcomes. Levodopa therapy may be considered in cases with residual amblyopia, although occlusion therapy remains the initial treatment choice. Regression of effect after stoppage of therapy remains a concern. Further studies are therefore needed to evaluate the full efficacy and side effect profile of these agents. PMID:29018759

  10. Lignite boost for North. [Northern Ireland

    Energy Technology Data Exchange (ETDEWEB)

    Clerkin, H.


    Reserves of lignite, estimated at around 500 million tonnes, have been discovered on the shores of Lough Neagh, Northern Ireland. The Government has granted a mining licence and planning permission to Burnett and Hallamshire Holdings to start work on the deposit. It is proposed to mine the lignite using opencast methods. Much of this deposit will be consumed in a purpose-built mine mouth power station with further reserves being dried in the approved processing plant to produce a range of industrial and domestic fuels. Carbonising the lignite may eliminate pollution. However, large scale investment will be required before Ireland's economy can switch to lignite.

  11. The visual arts in Northern Ireland hospitals. (United States)

    Cromie, H


    Since 1989 there has been a burgeoning of the visual arts in Northern Ireland hospitals. This paper compares the three organisational models for hospital arts currently operating within the Province and in an overview discusses ways to coordinate working practice for future development of the visual arts in local hospitals.

  12. The visual arts in Northern Ireland hospitals. (United States)

    Cromie, H.


    Since 1989 there has been a burgeoning of the visual arts in Northern Ireland hospitals. This paper compares the three organisational models for hospital arts currently operating within the Province and in an overview discusses ways to coordinate working practice for future development of the visual arts in local hospitals. Images Fig 1 Fig 2 Fig 3 PMID:8533183

  13. The Times and the Northern Ireland Conflict

    Directory of Open Access Journals (Sweden)

    Zouhaïr Abassi


    Full Text Available Abstract: In societies in conflict the role of the media is supposed to be neutral and to report conflicts fairly and with balanced analyses. By their public debates on conflicts they are also supposed to take part in pacifying societies and in helping to bring peace. Cottle (1997, for instance, explained that even though some findings related to the British media and its reporting of the Northern Ireland conflict were relevant, he argued that they needed revision. Consequently, he proposed new paradigms of media studies. Elliott (1977 and Curtis(1996 showed that the British media concentrated on violence in general and on republican violence in particular. Moreover, they argued that the British media neglected social and political contexts in their reporting of the conflict. The aim of this paper is then to examine some aspects of how the British media cover the Northern Ireland conflict. We studied the coverage of the Northern Ireland conflict by The (London Times (1990-1995. We used a discourse analysis method to study the paper’s discourse structure in its representation of the Northern Ireland conflict.

  14. Entrepreneurship Education: Ireland's Solution to Economic Regeneration? (United States)

    O'Connor, John; Fenton, Mary; Barry, Almar


    The significance of entrepreneurship has come into sharper focus as enterprise and innovation are being flagged as solutions to regenerate the Irish economy. The Irish Innovation Task Force believes that Ireland could become an "innovation hub", attracting foreign risk capital and international and indigenous entrepreneurs to start and…

  15. Climate change: potential implications for Ireland's biodiversity (United States)

    Donnelly, Alison


    A national biodiversity and climate change adaptation plan is being developed for Ireland by the Department of Communications, Climate Action, and Environment. In order to inform such a plan, it was necessary to review and synthesize some of the recent literature pertaining to the impact of climate change on biodiversity in Ireland. Published research on this topic fell within three broad categories: (i) changes in the timing of life-cycle events (phenology) of plants, birds, and insects; (ii) changes in the geographic range of some bird species; and (iii) changes in the suitable climatic zones of key habitats and species. The synthesis revealed evidence of (i) a trend towards earlier spring activity of plants, birds, and insects which may result in a change in ecosystem function; (ii) an increase in the number of bird species; and (iii) both increases and decreases in the suitable climatic area of key habitats and species, all of which are expected to impact Ireland's future biodiversity. This process identified data gaps and limitations in available information both of which could be used to inform a focused research strategy. In addition, it raises awareness of the potential implications of climate change for biodiversity in Ireland and elsewhere and demonstrates the need for biodiversity conservation plans to factor climate change into future designs.


    African Journals Online (AJOL)


    of modern research and the continued focus on the role of Irish Nationalism, the ... The absence of innovation amongst higher-ranked officers added to ... Chief, General Sir Redvers Buller, relieved the British garrison 118 days later. In ..... Yeomanry by aiding its organisation in Ireland, providing financial assistance to.

  17. Nursing care after death in Northern Ireland. (United States)

    Pearce, Lynne


    Essential facts According to the Registrar General Annual Report published in August 2016 there were 15,548 deaths in Northern Ireland in 2015, with almost two thirds being of people aged 75 or more. Almost half (48%) occurred in NHS hospitals, with a further 20% in other hospitals or nursing homes.

  18. Cancer mortality in Ireland, 1976-1986

    International Nuclear Information System (INIS)

    Seymour, C.; Herity, B.; Moriarty, M.J.


    This volume brings together in easily accessible form up-to-date mortality statistics for cancer for the Republic of Ireland. Because of small numbers in many of the malignant neoplasms studied rates and standardised mortality ratios have been calculated for the 11 year period 1976-86. Basic data only is presented, based on cancer type, location, sex and age group

  19. Many Voices: Building a Biblioblogosphere in Ireland (United States)

    Dalton, Michelle; Kouker, Alexander; O'Connor, Martin


    Blogging has been associated with the Library and Information Science (LIS) community for some time now. is an online blog that was founded in 2011. Its goal was to create a communal communication space for LIS professionals in Ireland and beyond, to share and discuss issues and ideas. The content of the blog is curated by an…

  20. Postgraduate training in Ireland: expectations and experience.

    LENUS (Irish Health Repository)

    Bennett, D


    Postgraduate medical training in Ireland has been compared unfavourably with training abroad and blamed for an "exodus" of graduates of Irish medical schools. Exploration of features of a good training environment and development of tools to measure it have been the focus of much published research. There have been no Irish studies examining training environment using such validated tools.

  1. Strategic Planning in Ireland's Institutes of Technology (United States)

    Elwood, Larry; Rainnie, Al


    This article focuses upon Ireland's institute of technology sector, which has been transformed from a 1970s technical orientation to its broader current role of research and higher education provision. The transformational shifts experienced by institutes over the previous three decades have been profound: increased autonomy, new managerial and…

  2. Randomised controlled trials of psychological & pharmacological treatments for body dysmorphic disorder: A systematic review. (United States)

    Phillipou, Andrea; Rossell, Susan L; Wilding, Helen E; Castle, David J


    Treatment for body dysmorphic disorder (BDD) often involves a combination of psychological and pharmacological interventions. However, only a small number of randomised controlled trials (RCTs) have been undertaken examining the efficacy of different therapeutic interventions. The aim of this study was to systematically review the RCTs involving psychological and pharmacological interventions for the treatment of BDD. The literature was searched to June 2015, and studies were included if they were written in English, empirical research papers published in peer-review journals, specifically assessed BDD patients, and involved a RCT assessing BDD symptoms pre- and post-intervention. Nine studies were identified: six involving psychological and three involving pharmacological interventions. Cognitive behaviour therapy, metacognitive therapy and selective serotonin reuptake inhibitors were identified as treatments with potential benefit. The small number of RCTs and the heterogeneity of findings emphasises the need for more high quality RCTs assessing both psychological and pharmacological interventions for BDD. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  3. A profile of physiotherapy supply in Ireland. (United States)

    Eighan, James; Walsh, Brendan; Smith, Samantha; Wren, Maev-Ann; Barron, Steve; Morgenroth, Edgar


    The lack of information on public and private physiotherapy supply in Ireland makes current and future resource allocation decisions difficult. This paper estimates the supply of physiotherapists in Ireland and profiles physiotherapists across acute and non-acute sectors, and across public and private practice. It examines geographic variation in physiotherapist supply, examining the implications of controlling for healthcare need. Physiotherapist headcounts are estimated using Health Service Personnel Census (HSPC) and Irish Society of Chartered Physiotherapists (ISCP) Register data. Headcounts are converted to whole-time equivalents (WTEs) using the HSPC and a survey of ISCP members to account for full- and part-time working practices. Non-acute supply per 10,000 population in each county is estimated to examine geographic inequalities and the raw population is adjusted in turn for a range of need indicators. An estimated 3172 physiotherapists were practising in Ireland in 2015; 6.8 physiotherapists per 10,000, providing an estimated 2620 WTEs. Females accounted for 74% of supply. Supply was greater in the non-acute sector; 1774 WTEs versus 846 WTEs in the acute sector. Physiotherapists in the acute sector were located mainly in publicly financed institutions (89%) with an even public/private split observed in the non-acute sector. Non-acute physiotherapist supply is unequally distributed across Ireland (Gini coefficient = 0.12; 95% CI 0.08-0.15), and inequalities remain after controlling for variations in healthcare needs across counties. The supply of physiotherapists in Ireland is 30% lower than the EU-28 average. Substantial inequality in the distribution of physiotherapists across counties is observed.

  4. [Pharmacological treatment of obesity]. (United States)

    Gomis Barbará, R


    The pharmacological treatment of obesity should be considered when cannot be achieved a 10% weight loss with diet therapy and physical activity. The drugs effective in obesity treatment may act by different mechanisms such as reduction in food intake, inhibition of fat absorption, increase of thermogenesis and stimulation of adipocyte apoptosis. At present, we only have two marketed drugs for obesity treatment. Sibutramine is an inhibitor of norepinephrine, dopamine and serotonina reuptake which inhibits food intake and increases thermogenesis. Sibutramine administration for a year can induce a weight loss of 4-7%. Its main side effects are hypertension, headache, insomnia and constipation. Orlistat is an inhibitor of pancreatic lipase which is able to block the absorption of 30% of ingested fat. Its administration induces weight loss and reduction of ulterior weight regain. Also, this drug improves hypertension dyslipdaemia and helps to prevent diabetes in 52% of cases when administered over four years. The increase in frequency of stools and interference with vitamin absorption are its main side effects. Glucagon-like peptide 1, which increases insulin sensitivity and satiety, adiponectin and PPAR-gamma agonists which reduce insulin resistance and modulates adipocyte generation are the basis for future therapeutic approaches of obesity. Phosphatase inhibitors induce PPAR-gamma phosphorylation and UCP-1 expression leading to an increase in thermogenesis and reduction in appetite.

  5. Pharmacological therapy of spondyloarthritis. (United States)

    Palazzi, Carlo; D'Angelo, Salvatore; Gilio, Michele; Leccese, Pietro; Padula, Angela; Olivieri, Ignazio


    The current pharmacological therapy of spondyloarthritis (SpA) includes several drugs: Non-steroidal anti-inflammatory drugs, corticosteroids, traditional disease-modifying antirheumatic drugs and biologic drugs. A systematic literature search was completed using the largest electronic databases (Medline, Embase and Cochrane), starting from 1995, with the aim to review data on traditional and biologic agents commercialised for SpA treatment. Randomised controlled trials and large observational studies were considered. In addition, studies performed in SpA patients treated with other, still unapproved, drugs (rituximab, anti-IL6 agents, apremilast, IL17 inhibitors and anakinra) were also taken into account. Biologic agents, especially anti-TNF drugs, have resulted in significant progress in improving clinical symptoms and signs, reducing inflammatory features in laboratory tests and imaging findings, and recovering all functional indexes. Anti-TNF drugs have radically changed the evolution of radiographic progression in peripheral joints; the first disappointing data concerning their efficacy on new bone formation of axial SpA has been recently challenged by studies enrolling patients who have been earlier diagnosed and treated. The opportunity to extend the interval of administration or to reduce the doses of anti-TNF agents can favourably influence the costs. Ustekinumab, the first non-anti-TNF biologic drug commercialised for psoriatic arthritis, offers new chances to patients that are unresponsive to anti-TNF.

  6. Pharmacology of midazolam. (United States)

    Pieri, L; Schaffner, R; Scherschlicht, R; Polc, P; Sepinwall, J; Davidson, A; Möhler, H; Cumin, R; Da Prada, M; Burkard, W P; Keller, H H; Müller, R K; Gerold, M; Pieri, M; Cook, L; Haefely, W


    8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine (midazolam, Ro 21-3981, Dormicum) is an imidazobenzodiazepine whose salts are soluble and stable in aqueous solution. It has a quick onset and, due to rapid metabolic inactivation, a rather short duration of action in all species studied. Midazolam has a similar pharmacologic potency and broad therapeutic range as diazepam. It produces all the characteristic effects of the benzodiazepine class, i.e., anticonvulsant, anxiolytic, sleep-inducing, muscle relaxant, and "sedative" effects. The magnitude of the anticonflict effect of midazolam is smaller than that of diazepam in rats and squirrel monkeys, probably because a more pronounced sedative component interferes with the increase of punished responses. In rodents, surgical anaesthesia is not attained with midazolam alone even in high i.v. doses, whereas this state is obtained in monkeys. The drug potentiates the effect of various central depressant agents. Midazolam is virtually free of effects on the cardiovascular system in conscious animals and produces only slight decreases in cardiac performance in dogs anaesthetized with barbiturates. No direct effects of the drugs on autonomic functions were found, however, stress-induced autonomic disturbances are prevented, probably by an effect on central regulatory systems. All animal data suggest the usefulness of midazolam as a sleep-inducer and i.v. anaesthetic of rapid onset and short duration.

  7. Pharmacology of pediatric resuscitation. (United States)

    Ushay, H M; Notterman, D A


    The resuscitation of children from cardiac arrest and shock remains a challenging goal. The pharmacologic principles underlying current recommendations for intervention in pediatric cardiac arrest have been reviewed. Current research efforts, points of controversy, and accepted practices that may not be most efficacious have been described. Epinephrine remains the most effective resuscitation adjunct. High-dose epinephrine is tolerated better in children than in adults, but its efficacy has not received full analysis. The preponderance of data continues to point toward the ineffectiveness and possible deleterious effects of overzealous sodium bicarbonate use. Calcium chloride is useful in the treatment of ionized hypocalcemia but may harm cells that have experienced asphyxial damage. Atropine is an effective agent for alleviating bradycardia induced by increased vagal tone, but because most bradycardia in children is caused by hypoxia, improved oxygenation is the intervention of choice. Adenosine is an effective and generally well-tolerated agent for the treatment of supraventricular tachycardia. Lidocaine is the drug of choice for ventricular dysrhythmias, and bretylium, still relatively unexplored, is in reserve. Many pediatricians use dopamine for shock in the postresuscitative period, but epinephrine is superior. Most animal research on cardiac arrest is based on models with ventricular fibrillation that probably are not reflective of cardiac arrest situations most often seen in pediatrics.

  8. The pharmacology of regenerative medicine. (United States)

    Christ, George J; Saul, Justin M; Furth, Mark E; Andersson, Karl-Erik


    Regenerative medicine is a rapidly evolving multidisciplinary, translational research enterprise whose explicit purpose is to advance technologies for the repair and replacement of damaged cells, tissues, and organs. Scientific progress in the field has been steady and expectations for its robust clinical application continue to rise. The major thesis of this review is that the pharmacological sciences will contribute critically to the accelerated translational progress and clinical utility of regenerative medicine technologies. In 2007, we coined the phrase "regenerative pharmacology" to describe the enormous possibilities that could occur at the interface between pharmacology, regenerative medicine, and tissue engineering. The operational definition of regenerative pharmacology is "the application of pharmacological sciences to accelerate, optimize, and characterize (either in vitro or in vivo) the development, maturation, and function of bioengineered and regenerating tissues." As such, regenerative pharmacology seeks to cure disease through restoration of tissue/organ function. This strategy is distinct from standard pharmacotherapy, which is often limited to the amelioration of symptoms. Our goal here is to get pharmacologists more involved in this field of research by exposing them to the tools, opportunities, challenges, and interdisciplinary expertise that will be required to ensure awareness and galvanize involvement. To this end, we illustrate ways in which the pharmacological sciences can drive future innovations in regenerative medicine and tissue engineering and thus help to revolutionize the discovery of curative therapeutics. Hopefully, the broad foundational knowledge provided herein will spark sustained conversations among experts in diverse fields of scientific research to the benefit of all.

  9. Pharmacology Portal: An Open Database for Clinical Pharmacologic Laboratory Services. (United States)

    Karlsen Bjånes, Tormod; Mjåset Hjertø, Espen; Lønne, Lars; Aronsen, Lena; Andsnes Berg, Jon; Bergan, Stein; Otto Berg-Hansen, Grim; Bernard, Jean-Paul; Larsen Burns, Margrete; Toralf Fosen, Jan; Frost, Joachim; Hilberg, Thor; Krabseth, Hege-Merete; Kvan, Elena; Narum, Sigrid; Austgulen Westin, Andreas


    More than 50 Norwegian public and private laboratories provide one or more analyses for therapeutic drug monitoring or testing for drugs of abuse. Practices differ among laboratories, and analytical repertoires can change rapidly as new substances become available for analysis. The Pharmacology Portal was developed to provide an overview of these activities and to standardize the practices and terminology among laboratories. The Pharmacology Portal is a modern dynamic web database comprising all available analyses within therapeutic drug monitoring and testing for drugs of abuse in Norway. Content can be retrieved by using the search engine or by scrolling through substance lists. The core content is a substance registry updated by a national editorial board of experts within the field of clinical pharmacology. This ensures quality and consistency regarding substance terminologies and classification. All laboratories publish their own repertoires in a user-friendly workflow, adding laboratory-specific details to the core information in the substance registry. The user management system ensures that laboratories are restricted from editing content in the database core or in repertoires within other laboratory subpages. The portal is for nonprofit use, and has been fully funded by the Norwegian Medical Association, the Norwegian Society of Clinical Pharmacology, and the 8 largest pharmacologic institutions in Norway. The database server runs an open-source content management system that ensures flexibility with respect to further development projects, including the potential expansion of the Pharmacology Portal to other countries. Copyright © 2016 Elsevier HS Journals, Inc. All rights reserved.

  10. An overview of Ireland's National Radon Policy

    International Nuclear Information System (INIS)

    Long, S.; Fenton, D.


    In Ireland radon is a significant public health issue and is linked to 150-200 lung cancer deaths each year. Irish National Radon Policy aims to reduce individual risk by identifying and remediating buildings with high radon concentrations and also to reduce collective dose through radon prevention as required by revised building regulations. Achievements to date are significant and include the completion of the National Radon Survey, the testing of every school in Ireland, the on-going testing of social housing, collaboration between the public health and radiation protection authorities and the inclusion of radon in inspections of workplaces. However, this work now needs to be drawn together centrally to comprehensively address the radon problem. The RPII and the relevant central governing department, the Dept. of Environment, Heritage and Local Government are currently working to constitute a group of key experts from relevant public authorities to drive the development of a National Radon Control Strategy. (authors)

  11. Food irradiation - a Northern Ireland dimension

    International Nuclear Information System (INIS)

    McMurray, C.H.; Stevenson, M.H.


    Irradiation is a technology which has been exploited in a wide variety of industries ranging from sterilization of medical products and polymer modification to applications with respect to food. Whilst food irradiation has recently become a controversial subject, the process has been studied for many years. Many products could be irradiated to advantage and these need to be thoroughly investigated before final recommendations can be made as to the commercial feasibility and suitability of the processing technology in the Northern Ireland context

  12. The Catholic Church and revolution in Ireland


    Ó hAdhmaill, Féilim


    Despite the involvement of radical socialists like James Connolly and the Irish Citizen Army in the 1916 Rising and the unanimous passing of the Democratic Programme (a socialist manifesto for the new Government) by the First Dáil in 1919, the Irish state has since its inception exhibited a highly conservative approach to social and economic policy, and politics generally in Ireland, North or South, have never faced a serious challenge from those seeking radical change. Several factors have p...

  13. Care of epidermolysis bullosa in Ireland.

    LENUS (Irish Health Repository)

    Watson, Rosemarie


    Advances in the medical care of epidermolysis bullosa (EB) have led to the development of National Service Centers for EB in many countries worldwide. The exemplary model of care to children and adults with EB in the United Kingdom, combined with the knowledge that people with EB were travelling to the United Kingdom for treatment, encouraged the development of the Irish national service. Dystrophic Epidermolysis Bullosa Research Association of Ireland, founded in 1988 played a pivotal role in this development.

  14. Enterprise Ireland: Student Creativity Day Design Competition


    Dee, Peter


    Peter Dee - Strategic Design & Marketing Consultant, was responsible for the design and development of the brand identity for the Enterprise Ireland Student Creativity Day which was used on business cards, letterhead, appliction forms, information literature, large format posters, t-shirts and website. Competing in multi-disciplinary teams, students provided an innovative & creative solution to an exacting design brief. The design brief reflected the following themes: interface, learning, sci...

  15. ENTERPRISE IRELAND: Design for Competitive Advantage Conference


    Dee, Peter


    A stimulating conference bringing together world leading experts on design to address the importance of brand development strategies to achieve competitive advantage. Peter Dee - Strategic Design and Marketing Consultant, specialised in the creation of brand development strategies for Enterprise Ireland’s Design Unit. Peter was responsible for the design and development of the the brand identity for the Enterprise Ireland Design for Competitive Advantage Conference in Dublin.

  16. Fuzzy pharmacology: theory and applications. (United States)

    Sproule, Beth A; Naranjo, Claudio A; Türksen, I Burhan


    Fuzzy pharmacology is a term coined to represent the application of fuzzy logic and fuzzy set theory to pharmacological problems. Fuzzy logic is the science of reasoning, thinking and inference that recognizes and uses the real world phenomenon that everything is a matter of degree. It is an extension of binary logic that is able to deal with complex systems because it does not require crisp definitions and distinctions for the system components. In pharmacology, fuzzy modeling has been used for the mechanical control of drug delivery in surgical settings, and work has begun evaluating its use in other pharmacokinetic and pharmacodynamic applications. Fuzzy pharmacology is an emerging field that, based on these initial explorations, warrants further investigation.

  17. Individual Education Plans in the Republic of Ireland: An Emerging System (United States)

    Rose, Richard; Shevlin, Michael; Winter, Eileen; O'Raw, Paul; Zhao, Yu


    The Education for Persons with Special Educational Needs Act in Ireland advocated the development of individual education plans (IEPs). However, this section of the Act has never been fully implemented and there is no obligation upon schools to develop IEPs. Research conducted across the country by Richard Rose and Yu Zhao of the University of…

  18. 19 CFR 10.69 - Samples to Great Britain and Ireland under reciprocal agreement. (United States)


    ... the United States and one for the use of the foreign customs authorities. The latter copy must have... 19 Customs Duties 1 2010-04-01 2010-04-01 false Samples to Great Britain and Ireland under reciprocal agreement. 10.69 Section 10.69 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF...

  19. Patterns of Substance Use among Young People Attending Colleges of Further Education in Northern Ireland (United States)

    McCrystal, Patrick; Percy, Andrew


    Aims: Substance use and misuse amongst young people attending colleges of further education (FE) has received little attention in the drug use literature in the UK. This article aims to explore the patterns of drug use amongst young people attending colleges of further education in Northern Ireland. Methods: A cross-sectional questionnaire survey…

  20. Microseism Source Distribution Observed from Ireland (United States)

    Craig, David; Bean, Chris; Donne, Sarah; Le Pape, Florian; Möllhoff, Martin


    Ocean generated microseisms (OGM) are recorded globally with similar spectral features observed everywhere. The generation mechanism for OGM and their subsequent propagation to continental regions has led to their use as a proxy for sea-state characteristics. Also many modern seismological methods make use of OGM signals. For example, the Earth's crust and upper mantle can be imaged using ``ambient noise tomography``. For many of these methods an understanding of the source distribution is necessary to properly interpret the results. OGM recorded on near coastal seismometers are known to be related to the local ocean wavefield. However, contributions from more distant sources may also be present. This is significant for studies attempting to use OGM as a proxy for sea-state characteristics such as significant wave height. Ireland has a highly energetic ocean wave climate and is close to one of the major source regions for OGM. This provides an ideal location to study an OGM source region in detail. Here we present the source distribution observed from seismic arrays in Ireland. The region is shown to consist of several individual source areas. These source areas show some frequency dependence and generally occur at or near the continental shelf edge. We also show some preliminary results from an off-shore OBS network to the North-West of Ireland. The OBS network includes instruments on either side of the shelf and should help interpret the array observations.

  1. National survey of MRSA: Ireland, 1995.

    LENUS (Irish Health Repository)

    Johnson, Z


    The objective of this survey was to obtain an indication of the size of the methicillin-resistant Staphylococcus aureus (MRSA) problem in Ireland prior to introducing national MRSA control guidelines. A survey of all microbiology laboratories in Ireland was carried out over two weeks in Spring 1995. For patients from whom MRSA was isolated during the study period standard demographic and clinical data were requested and period prevalence\\/1000 discharges was calculated. All 45 microbiology laboratories surveyed responded. MRSA was isolated from 448 patients during the two-week period. The period prevalence of MRSA was 16.5\\/1000 discharges. Males aged > or = 65 had the highest rate (50\\/1000 discharges). Half of all isolates were from patients in surgical or medical wards, but 4% were from community-based sources such as GPs, nursing homes and hospices. Thirty-two percent of MRSA patients were infected rather than colonized. MRSA is clearly a significant problem in Ireland. While it is largely a hospital problem at present, the increasing trend towards day procedures and shorter hospital stay means that infection will increase in the community.

  2. The pharmacology of gynaecology. (United States)

    Tothill, A


    Focus in this discussion of the pharmacology of gynecology is on the following: vaginal infections; genital herpes; genital warts; pelvic inflammatory disease; urinary infections; pruritus vulvae; menstrual problems; infertility; oral contraception; and hormone replacement therapy. Doctors in England working in Local Authority Family Planning Clinics are debarred from prescribing, and any patient with a vaginal infection has to be referred either to a special clinic or to her general practitioner which is often preferable as her medical history will be known. Vaginal discharge is a frequent complaint, and it is necessary to obtain full details. 1 of the most common infections is vaginal candidosis. Nystatin pessaries have always been a useful 1st-line treatment and are specific for this type of infection. Trichomonas infection also occurs frequently and responds well to metronidazole in a 200 mg dosage, 3 times daily for 7 days. It is necessary to treat the consort at the same time. Venereal diseases such as syphilis and gonorrhea always require vigorous treatment. Patients are now presenting with herpes genitalis far more often. The only treatment which is currently available, and is as good as any, is the application of warm saline to the vaginal area. Genital warts may be discovered on routine gynecological examination or may be reported to the doctor by the patient. 1 application of a 20% solution of podophyllum, applied carefully to each wart, usually effects a cure. Pelvic inflammatory disease seems to be on the increase. Provided any serious disease is ruled out a course of systemic antibiotics is often effective. Urinary infections are often seen in the gynecologic clinic, and many of these will respond well to 2 tablets of co-trimoxazole, 2 times daily for 14 days. In pruritus vulvae it is important to determine whether the cause is general or local. Menstrual problems regularly occur and have been increased by the IUD and the low-dose progesterone pill

  3. Migrants and racial minorities in the labour market in Ireland


    Vasquez del Aguila, Ernesto; Cantillon, Sara


    This report analyses the situation of migrant workers and ethnic minorities in Ireland over the post-economic boom period. From the mid-1990s to the mid-2000s, Ireland experienced extraordinary economic growth and this brought with it an unprecedented increase in the migrant population. As a result of the economic crisis, the total number of migrants coming to Ireland has fallen dramatically. However, despite this situation, Ireland is likely to remain a multicultural society and ethnic diver...

  4. Benchmarking care for very low birthweight infants in Ireland and Northern Ireland.

    LENUS (Irish Health Repository)

    Murphy, B P


    BACKGROUND: Benchmarking is that process through which best practice is identified and continuous quality improvement pursued through comparison and sharing. The Vermont Oxford Neonatal Network (VON) is the largest international external reference centre for very low birth weight (VLBW) infants. This report from 2004-7 compares survival and morbidity throughout Ireland and benchmarks these results against VON. METHODS: A standardised VON database for VLBW infants was created in 14 participating centres across Ireland and Northern Ireland. RESULTS: Data on 716 babies were submitted in 2004, increasing to 796 babies in 2007, with centres caring for from 10 to 120 VLBW infants per year. In 2007, mortality rates in VLBW infants varied from 4% to 19%. Standardised mortality ratios indicate that the number of deaths observed was not significantly different from the number expected, based on the characteristics of infants treated. There was no difference in the incidence of severe intraventricular haemorrhage between all-Ireland and VON groups (5% vs 6%, respectively). All-Ireland rates for chronic lung disease (CLD; 15-21%) remained lower than rates seen in the VON group (24-28%). The rates of late onset nosocomial infection in the all-Ireland group (25-26%) remained double those in the VON group (12-13%). DISCUSSION: This is the first all-Ireland international benchmarking report in any medical specialty. Survival, severe intraventricular haemorrhage and CLD compare favourably with international standards, but rates of nosocomial infection in neonatal units are concerning. Benchmarking clinical outcomes is critical for quality improvement and informing decisions concerning neonatal intensive care service provision.

  5. [Pharmacological therapy of obesity]. (United States)

    Pagotto, Uberto; Vanuzzo, Diego; Vicennati, Valentina; Pasquali, Renato


    Obesity is reaching epidemic proportions worldwide and it is correlated with various comorbidities, among which the most relevant are diabetes mellitus, arterial hypertension, and cardiovascular diseases. Obesity management is a modern challenge because of the rapid evolution of unfavorable lifestyles and unfortunately there are no effective treatments applicable to the large majority of obese/overweight people. The current medical attitude is to treat the complications of obesity (e.g. dyslipidemia, hypertension, diabetes, and cardiovascular diseases). However, the potential of treating obesity is enormous, bearing in mind that a volitional weight loss of 10 kg is associated with important risk factor improvement: blood pressure -10 mmHg, total cholesterol -10%, LDL cholesterol -15%, triglycerides -30%, fasting glucose -50%, HDL cholesterol +8%. Drug treatment for obesity is an evolving branch of pharmacology, burdened by severe side effects and consequences of the early drugs, withdrawn from the market, and challenged by the lack of long-term data on the effect of medications on obesity-related morbidity and mortality, first of all cardiovascular diseases. In Europe three antiobesity drugs are currently licensed: sibutramine, orlistat, and rimonabant; important trials with clinical endpoints are ongoing for sibutramine and rimonabant. While waiting for their results, it is convenient to evaluate these drugs for their effects on body weight and cardiometabolic risk factors. Sibutramine is a centrally acting serotonin/noradrenaline reuptake inhibitor that mainly increases satiety. At the level of brown adipose tissue, sibutramine can also facilitate energy expenditure by increasing thermogenesis. The long-term studies (five) documented a mean differential weight reduction of 4.45 kg for sibutramine vs placebo. Considering the principal studies, attrition rate was 43%. This drug not only reduces body weight and waist circumference, but it decreases triglycerides and

  6. Entrepreneurship in Ireland 2012: global entrepreneurship monitor (GEM)


    Fitzsimons, Paula; O'Gorman, Colm


    Report on entrepreneurship in Ireland in the year 2012. Data used is the Global Entrepreneurship Monitor (GEM) data for Ireland and selected comparative countries. The report profiles entrepreneurs, reports on the rate of entrepreneurship in Ireland, discusses female entrepreneurship, and positions these results in the context of Irish entrepreneurship policy.

  7. The impact of comorbid post-traumatic stress disorder in patients with major depressive disorder on clinical features, pharmacological treatment strategies, and treatment outcomes - Results from a cross-sectional European multicenter study. (United States)

    Dold, Markus; Bartova, Lucie; Kautzky, Alexander; Souery, Daniel; Mendlewicz, Julien; Serretti, Alessandro; Porcelli, Stefano; Zohar, Joseph; Montgomery, Stuart; Kasper, Siegfried


    This international, multicenter, cross-sectional study comprising 1346 adult in- and outpatients with major depressive disorder (MDD) investigated the association between MDD as primary diagnosis and comorbid post-traumatic stress disorder (PTSD). In a cross-sectional data collection process, the presence of comorbid PTSD was determined by the Mini International Neuropsychiatric Interview (MINI) and the patients' socio-demographic, clinical, psychopharmacological, and response information were obtained. Clinical features between MDD with and without concurrent PTSD were compared using descriptive statistics, analyses of covariance (ANCOVA), and binary logistic regression analyses. 1.49% of the MDD patients suffered from comorbid PTSD. Significantly more MDD + comorbid PTSD patients exhibited atypical features, comorbid anxiety disorders (any comorbid anxiety disorder, panic disorder, agoraphobia, and social phobia), comorbid bulimia nervosa, current suicide risk, and augmentation treatment with low-dose antipsychotic drugs. In the binary logistic regression analyses, the presence of atypical features (odds ratio (OR) = 4.49, 95%CI:1.01-20.12; p≤.05), any comorbid anxiety disorder (OR = 3.89, 95%CI:1.60-9.44; p = .003), comorbid panic disorder (OR = 6.45, 95%CI:2.52-16.51; p = .001), comorbid agoraphobia (OR = 6.51, 95%CI:2.54-16.68; p≤.001), comorbid social phobia (OR = 6.16, 95%CI:1.71-22.17; p≤.001), comorbid bulimia nervosa (OR = 10.39, 95%CI:1.21-88.64; p = .03), current suicide risk (OR = 3.58, 95%CI:1.30-9.91; p = .01), and augmentation with low-potency antipsychotics (OR = 6.66, 95%CI:2.50-17.77; pdisorders, and (3.) the increased suicide risk due to concurrent PTSD. Copyright © 2017 Elsevier B.V. and ECNP. All rights reserved.

  8. International trends in health science librarianship Part 8: the UK and the Republic of Ireland Northern Ireland.

    LENUS (Irish Health Repository)

    Latimer, Karen


    This is the 8th in a series of articles exploring international trends in health science librarianship with a focus on the UK and Ireland in the first decade of the 21st century. The invited authors are from Northern Ireland and the Republic of Ireland. Future issues will track trends from Scotland and Wales.

  9. Quality management of pharmacology and safety pharmacology studies

    DEFF Research Database (Denmark)

    Spindler, Per; Seiler, Jürg P


    to safety pharmacology studies, and, when indicated, to secondary pharmacodynamic studies, does not influence the scientific standards of studies. However, applying formal GLP standards will ensure the quality, reliability and integrity of studies, which reflect sound study management. It is important...... to encourage a positive attitude among researchers and academics towards these lines, whenever possible. GLP principles applied to the management of non-clinical safety studies are appropriate quality standards when studies are used in the context of protecting public health, and these quality standards...... of pharmacology studies (ICH S7A): primary pharmacodynamic, secondary pharmacodynamic and safety pharmacology studies, and guidance on the quality standards (expectations for GLP conformity) for these study types have been provided. Primary pharmacodynamic studies are the only study types that are fully exempt...

  10. Pregnancy risk assessment monitoring system in Ireland: methods and response rates

    LENUS (Irish Health Repository)

    O’Keeffe, Linda M.


    To describe response rates and characteristics associated with response to the Pregnancy Risk Assessment Monitoring System study in Ireland (PRAMS Ireland). Using hospital discharge records of live births at a large, urban, obstetric hospital, a sampling frame of approximately 2,400 mother-infant pairs were used to alternately sample 1,200 women. Mothers’ information including name, address, parity, age and infant characteristics such as sex and gestational age at delivery were extracted from records. Modes of contact included an invitation letter with option to opt out of the study, three mail surveys, a reminder letter and text message reminder for remaining non-respondents. Sixty-one per cent of women responded to the PRAMS Ireland survey over a 133 day response period. Women aged <30, single women, multiparous women and women with a preterm delivery were less likely to respond. Women participating in PRAMS Ireland were similar to the national birth profile in 2011 which had a mean age of 32, were 40 % primiparous, 33 % single or never married and had a 28 % caesarean section rate. Survey and protocol changes are required to increase response rates above recommended Centers for Disease Control and Prevention (CDC) thresholds of 65 % within the recommended 90 day data collection cycle. Additional efforts such as stratification and over-sampling are required to increase representativeness among hard to reach groups such as younger, single and multiparous women before expanding the project to an ongoing, national surveillance system in Ireland.


    Directory of Open Access Journals (Sweden)

    Gataullina, K.N.


    Full Text Available The globalization processes put a number of regional languages on the verge of extinction, therefore, they have raised awareness of protecting and maintaining the minority languages among a great number of foreign and Russian scholars. The paper deals with Irish that is under protection of the European Charter for regional and Minority Languages in UK and is an official language of Ireland. The research is aimed at comparing the Irish language position in both regions: Ireland and Northern Ireland. Reviewing the quantitative data in the regions under the study allows us to see clearly the language situation, monitor development, and relying on the achieved results, assess the current state and predict the future of Irish in both regions. The research results are considered to be of practical use for further language planning, improving the efficiency of language policies.

  12. Stress among nurses working in an acute hospital in Ireland.

    LENUS (Irish Health Repository)

    Donnelly, Teresa


    Stress among nurses leads to absenteeism, reduced efficiency, long-term health problems and a decrease in the quality of patient care delivered. A quantitative cross-sectional study was conducted. The study\\'s aim was to identify perceived stressors and influencing factors among nurses working in the critical and non-critical care practice areas. A convenience sample of 200 nurses were invited to complete the Bianchi Stress Questionnaire. Information was collected on demographics and daily nursing practice. Findings indicated that perceived stressors were similar in both groups. The most severe stressors included redeployment to work in other areas and staffing levels. Results from this study suggest that age, job title, professional experience and formal post-registration qualifications had no influence on stress perception. These results will increase awareness of nurses\\' occupational stress in Ireland.

  13. Natural radioactivity in groundwater sources in Ireland

    Energy Technology Data Exchange (ETDEWEB)

    Currivan, L.; Dowdall, A.; Mcginnity, P.; Ciara, M. [Radiological Protection Institute of Ireland (Ireland); Craig, M. [Environmental Protection Agency (Ireland)


    The Radiological Protection Institute of Ireland (RPII) in collaboration with the Irish Environmental Protection Agency (EPA) undertook a national survey of radioactivity in groundwater sources for compliance with parameters set out in the European Communities Drinking Water Directive. The Directive outlines the minimum requirements for the quality of drinking water and water intended for human consumption. Over two hundred samples were screened for radioactivity. Where indicated, analysis for individual radionuclide activity was undertaken and the radiation dose arising calculated. Furthermore, samples were analysed for radon concentration. This survey is the first comprehensive national survey of radioactivity in groundwater sources in Ireland. Approximately 18 per cent of drinking water in Ireland originates from groundwater and springs with the remainder from surface water. Between 2007 and 2011, water samples from a representative network of groundwater sources were analysed and assessed for compliance with the radioactivity parameters set out in the Drinking Water Directive. The assessment was carried out using the methodology for screening drinking water set out by the WHO. For practical purposes the WHO recommended screening levels for drinking water below which no further action is required of 100 mBq/l for gross alpha activity and 1000 mBq/l for gross beta activity were applied. Of the 203 groundwater sources screened for gross alpha and gross beta all met the gross beta activity criteria of less than 1000 mBq/l and 175 supplies had gross alpha activity concentrations of less than 100 mBq/l. For these sources no further analysis was required. The remaining 28 sources required further (radionuclide-specific) analysis from an alpha activity perspective. Results on ranges and distributions of radionuclide concentrations in groundwater as well as ingestion doses estimated for consumers of these water supplies will be presented. Document available in abstract

  14. Energy in Ireland: context, strategy and research

    International Nuclear Information System (INIS)

    Saintherant, N.; Lerouge, Ch.; Welcker, A.


    In the present day situation of sudden awareness about climatic change and announced fossil fuels shortage, Ireland has defined a new strategy for its energy future. Context: Ireland is strongly dependent of oil and gas imports which increase regularly to meet the demand. A small part of the electricity consumed is imported from Ulster. The share of renewable energies remains weak but is increasing significantly. Therefore, from 1990 to 2006, the proportion of renewable energies increased from 1.9% (mainly of hydroelectric origin) to 4.5%. Wind power represents now the main renewable energy source. The transportation sector is the most energy consuming and the biggest source of greenhouse gases. Strategy: the Irish policy is driven by pluri-annual strategic plans which define the objectives and means. Priority is given to the security of supplies at affordable prices: 8.5 billion euros will be invested during the 2007-2013 era for the modernization of existing energy infrastructures and companies, and in a lesser extent for the development of renewable energy sources. During this period, 415 million euros more will be devoted to the research, development and demonstration (RD and D) of new energy solutions. Research: in 2005 the energy RD and D expenses reached 12.8 million euros shared between 54% for R and D and 46% for demonstration projects. Half of the financing is given to higher education schools and is devoted to energy saving purposes (33%) and to renewable energies (29%, mainly wind power and biomass). Academic research gives a particular attention to ocean energy which represents an important potential resource in Ireland and which has already led to the creation of innovative companies. The integration of renewable energy sources to the power grid and the stability of supplies are also the object of active researches. (J.S.)

  15. Space Radar Image of County Kerry, Ireland (United States)


    The Iveragh Peninsula, one of the four peninsulas in southwestern Ireland, is shown in this spaceborne radar image. The lakes of Killarney National Park are the green patches on the left side of the image. The mountains to the right of the lakes include the highest peaks (1,036 meters or 3,400 feet) in Ireland. The patchwork patterns between the mountains are areas of farming and grazing. The delicate patterns in the water are caused by refraction of ocean waves around the peninsula edges and islands, including Skellig Rocks at the right edge of the image. The Skelligs are home to a 15th century monastery and flocks of puffins. The region is part of County Kerry and includes a road called the 'Ring of Kerry' that is one of the most famous tourist routes in Ireland. This image was acquired by the Spaceborne Imaging Radar-C/X-band Synthetic Aperture Radar (SIR-C/X-SAR) onboard the Space Shuttle Endeavour on April 12, 1994. The image is 82 kilometers by 42 kilometers (51 miles by 26 miles) and is centered at 52.0 degrees north latitude, 9.9 degrees west longitude. North is toward the lower left. The colors are assigned to different radar frequencies and polarizations of the radar as follows: red is L-band, horizontally transmitted and received; green is L-band, vertically transmitted and received; and blue is C-band, vertically transmitted and received. SIR-C/X-SAR, a joint mission of the German, Italian and United States space agencies, is part of NASA's Mission to Planet Earth program.

  16. A Multi-Level Analysis of World Scientific Output in Pharmacology


    Olmeda-Gómez, Carlos; Ovalle-Perandones, María Antonia; Perianes-Rodríguez, Antonio


    The purpose of this chapter is to analyse international research in “pharmacology, toxicology and pharmaceutics” (hereafter pharmacology) on the basis of the scientific papers listed in the Scopus multidisciplinary database. This primary objective is reached by answering the following questions (in the section on results). What weight does the subject area “pharmacology, toxicology and pharmaceutics” carry in world-wide science? What is the percentage contribution made by the various regions ...

  17. Modelling the wind climate of Ireland

    DEFF Research Database (Denmark)

    Frank, H.P.; Landberg, L.


    The wind climate of Ireland has been calculated using the Karlsruhe Atmospheric Mesoscale Model KAMM. The climatology is represented by 65 frequency classes of geostrophic wind that were selected as equiangular direction sectors and speed intervals with equal frequency in a sector. The results...... are compared with data from the European Wind Atlas which have been analyzed using the Wind Atlas Analysis and Application Program, WA(S)P. The prediction of the areas of higher wind power is fair. Stations with low power are overpredicted....

  18. The Criminal justice system in Northern Ireland


    Carr, Nicola


    As with any country, crime and justice and the contours of criminal justice have to be situated within the particular historical, social, and political context. Nowhere is this truer than in Northern Ireland, where the criminal justice system that has emerged has been shaped by a violent political conflict which spanned over three decades (from the late 1960s to the late 1990s). In the transition to peace, the reform of criminal justice agencies has been central—to a wider project of state le...

  19. Country policy profile - Ireland. December 2015

    International Nuclear Information System (INIS)


    In Ireland, electricity from renewable sources is mainly promoted through a feed-in-tariff scheme (REFIT). There is also a tax relief scheme for corporate investments in projects generating electricity from renewable sources (solar, wind, biomass, and hydro). Renewable Energy sources for heating purposes have two main support schemes: a grant to homeowners for the installation of solar thermal installations and a tax return to Irish companies of 100% of the purchase value of certain energy efficient equipment. The main incentive for renewable energy use in transport is a quota system (RES-Legal Europe, 2014)

  20. MhicMathúna v Ireland


    Thornton, Liam


    This is a feminist re-imagining of the Supreme Court decision MhicMathúna v Ireland [1995] 1 I.R. 454. The actual Supreme Court decision in this case continues to have a profound impact upon how the Irish superior courts view constitutional socio-economic rights claims. This feminist judgment seeks to re-situate the legal analysis of constitutionalised socio-economic rights claims. However, this, as is seen from the feminist judgment, has not been an easy task. The plaintiffs' in this case at...

  1. Country policy profile - Ireland. August 2015

    International Nuclear Information System (INIS)


    In Ireland, electricity from renewable sources is mainly promoted through a feed-in-tariff scheme (REFIT). There is also a tax relief scheme for corporate investments in projects generating electricity from renewable sources (solar, wind, biomass, and hydro). Renewable Energy sources for heating purposes have two main support schemes: a grant to homeowners for the installation of solar thermal installations and a tax return to Irish companies of 100% of the purchase value of certain energy efficient equipment. The main incentive for renewable energy use in transport is a quota system (RES-Legal Europe, 2014)

  2. The Coming Out Experience in Ireland


    Rooney, Andrew J


    The following thesis will tackle research into the coming out experience in Ireland and the affects of such experience. Such a topic is of importance to social care workers as the LGBT community are more likely to experience stress, depression, suicide ideation and drug use. The research reviewed was divided up into the following themes, in order to answer the research question; ‘age of realisation versus age of coming out, the ‘LGBT stereotype’, ‘experience of homophobia, the ‘acceptance ...

  3. Security of supply in Ireland 2006

    International Nuclear Information System (INIS)

    Bazilian, Morgan; O'Leary, Fergal; O Gallachoir, Brian; Howley, Martin


    This is the second annual report on the title theme from SEI. Since SEI's initial security of supply publication there has been considerable attention paid to the security of supply aspects of energy policy worldwide. This reports updates and refines the metrics used to consider security of supply in Ireland. It also presents new analysis in three areas; the development of a supply/demand index, use of mean variance portfolio analysis for the electricity sector and a high oil price energy forecast scenario

  4. Radioactivity in Northern Ireland soils - December 1986

    International Nuclear Information System (INIS)

    Jenkins, D.W.K.


    The main objective of the survey was to establish the radionuclide content of permanent pasture soils. The extent of contamination from the Chernobyl accident was also studied with the use of Cs-134 as an indicator of Chernobyl fallout. A preliminary radiological assessment was performed by referring to the generalised derived limits. Results of the grassland grid survey show that Chernobyl-derived radiocaesium was widely spread throughout Northern Ireland with the exception of the East Coast where the deposition was more localised reflecting the showery-rainfall pattern on the 3rd May 1986. Accumulation of Chernobyl material showed a high correlation with rainfall on that day, which resulted in a substantial increase in Cs-137 levels compared to estimated pre-Chernobyl concentrations in many areas. The main areas affected lay in a band across the country from the North East to the South with a smaller incursion to the North. The plutonium content in soils from Northern Ireland arising from nuclear weapons fallout was similar to levels found in other surveys completed in Great Britain before Chernobyl. (author)

  5. The genus Psiadia: Review of traditional uses, phytochemistry and pharmacology. (United States)

    Mahadeo, Keshika; Grondin, Isabelle; Kodja, Hippolyte; Soulange Govinden, Joyce; Jhaumeer Laulloo, Sabina; Frederich, Michel; Gauvin-Bialecki, Anne


    of growth of Plasmodium falciparum. However, pharmacological data on this particular genus is quite limited. Further research is necessary to determine the active compounds and the underlying mechanisms. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

  6. Ethnobotany, phytochemistry and pharmacology of Stephania rotunda Lour. (United States)

    Desgrouas, Camille; Taudon, Nicolas; Bun, Sok-Siya; Baghdikian, Beatrice; Bory, Sothavireak; Parzy, Daniel; Ollivier, Evelyne


    ailments. Pharmacological investigations have validated different uses of Stephania rotunda in folk medicine. The present review highlights the three most promising compounds of Stephania rotunda, which could constitute potential leads in various medicinal fields, including malaria and cancer. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  7. Passing through - reasons why migrant doctors in Ireland plan to stay, return home or migrate onwards to new destination countries. (United States)

    Brugha, Ruairí; McAleese, Sara; Dicker, Pat; Tyrrell, Ella; Thomas, Steve; Normand, Charles; Humphries, Niamh


    International recruitment is a common strategy used by high-income countries to meet their medical workforce needs. Ireland, despite training sufficient doctors to meet its internal demand, continues to be heavily dependent on foreign-trained doctors, many of whom may migrate onwards to new destination countries. A cross-sectional study was conducted to measure and analyse the factors associated with the migratory intentions of foreign doctors in Ireland. A total of 366 non-European nationals registered as medical doctors in Ireland completed an online survey assessing their reasons for migrating to Ireland, their experiences whilst working and living in Ireland, and their future plans. Factors associated with future plans - whether to remain in Ireland, return home or migrate to a new destination country - were tested by bivariate and multivariate analyses, including discriminant analysis. Of the 345 foreign doctors who responded to the question regarding their future plans, 16 % of whom were Irish-trained, 30 % planned to remain in Ireland, 23 % planned to return home and 47 % to migrate onwards. Country of origin, personal and professional reasons for migrating, experiences of training and supervision, opportunities for career progression, type of employment contract, citizenship status, and satisfaction with life in Ireland were all factors statistically significantly associated with the three migratory outcomes. Reported plans may not result in enacted emigration. However, the findings support a growing body of evidence highlighting dissatisfaction with current career opportunities, contributing to the emigration of Irish doctors and onward migration of foreign doctors. Implementation of the WHO Global Code, which requires member states to train and retain their own health workforce, could also help reduce onward migration of foreign doctors to new destination countries. Ireland has initiated the provision of tailored postgraduate training to doctors from

  8. Pharmacology Experiments on the Computer. (United States)

    Keller, Daniel


    A computer program that replaces a set of pharmacology and physiology laboratory experiments on live animals or isolated organs is described and illustrated. Five experiments are simulated: dose-effect relationships on smooth muscle, blood pressure and catecholamines, neuromuscular signal transmission, acetylcholine and the circulation, and…

  9. Pharmacology of Marihuana (Cannabis sativa) (United States)

    Maickel, Roger P.


    A detailed discussion of marihuana (Cannabis sativa) providing the modes of use, history, chemistry, and physiologic properties of the drug. Cites research results relating to the pharmacologic effects of marihuana. These effects are categorized into five areas: behavioral, cardiovascular-respiratory, central nervous system, toxicity-toxicology,…

  10. Chemotaxonomy and pharmacology of Gentianaceae

    DEFF Research Database (Denmark)

    Jensen, Søren Rosendal; Schripsema, Jan


    the remaining six are members of the Gentianeae. Based on the above results, a tentative list of chemical characteristics for the tribes of the Gentianaceae is presented. Finally, some pharmacologically interesting properties of plant extracts or compounds from taxa within Gentianaceae are listed....

  11. 21 CFR 320.28 - Correlation of bioavailability with an acute pharmacological effect or clinical evidence. (United States)


    ... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Correlation of bioavailability with an acute pharmacological effect or clinical evidence. 320.28 Section 320.28 Food and Drugs FOOD AND DRUG ADMINISTRATION... Correlation of bioavailability with an acute pharmacological effect or clinical evidence. Correlation of in...

  12. Factors influencing initiation and duration of breast feeding in Ireland.

    LENUS (Irish Health Repository)

    Leahy-Warren, Patricia


    The aim of this research was to identify factors associated with mothers breast feeding and to identify, for those who breast fed, factors associated with breast feeding for as long as planned. BACKGROUND: breast-feeding rates in Ireland are amongst the lowest in Europe. Research evidence indicates that in order for mothers to be successful at breast feeding, multiplicities of supports are necessary for both initiation and duration. The nature of these supports in tandem with other influencing factors requires analysis from an Irish perspective. DESIGN: cross-sectional study involving public health nurses and mothers in Ireland. This paper presents the results of the mothers\\' evaluation. METHOD: mothers (n=1715) with children less than three years were offered a choice of completing the self-report questionnaires online or by mail. Data were analysed and reported using descriptive and inferential statistics. FINDINGS: four in every five participants breast fed their infant and two thirds of them breast fed as long as planned. The multivariate logistic regression analysis identified that third level education, being a first time mother or previously having breast fed, participating online, having more than two public health nurse visits, and having a positive infant feeding attitude were independently and statistically significantly associated with breast feeding. Among mothers who breast fed, being aged at least 35 years, participating online, having a positive infant feeding attitude and high breast-feeding self-efficacy were independently and statistically significantly associated with breast feeding for as long as planned. CONCLUSIONS: findings from this study reinforce health inequalities therefore there needs to be a renewed commitment to reducing health inequalities in relation to breast feeding. RELEVANCE TO CLINICAL PRACTICE: this study has identified factors associated with initiation and duration of breast feeding that are potentially modifiable through

  13. United Kingdom Ireland coal ports directory

    Energy Technology Data Exchange (ETDEWEB)


    The directory gives details of ports at 65 locations in the UK and Ireland. For each port, the directory lists the name of the terminal; the name, address, contact name and numbers of the terminal owner and of the terminal operator; and the name and telephone/fax numbers of ship's agents. It also give details, for each terminal, where available, of tidal rise, access routes, vessel maxima, working hours, coal traders and handlers, discharge facilities, daily discharge rate, coal loading facilities, daily loading rate, stocking area dimensions and capacity, stocking area facilities and inland transport infrastructure. Research for the directory was undertaken by S. Fazal and C. Measham of Sheffield Hallam University, Business School.

  14. Energy use and appliance ownership in Ireland

    International Nuclear Information System (INIS)

    Leahy, Eimear; Lyons, Sean


    This paper examines household energy use and appliance ownership in Ireland. Logit regression analyses on a large micro-dataset reveal how household characteristics can help explain the ownership of energy using appliances. Using OLS regression models, we explore the factors affecting residential energy demand conditional on appliance ownership. Results suggest that the methods of space and water heating employed by a household are even more important than electrical appliances in explaining domestic energy usage. However, the stock of appliances must be included in such models so that results will not be biased. The methods employed in this paper can be easily adopted for studies of household energy use in other countries where household expenditure survey data are available.

  15. The current epidemiology of SIDS in Ireland.

    LENUS (Irish Health Repository)

    Mehanni, M


    This paper examines some epidemiological factors associated with SIDS to give a general profile of SIDS cases occurring in Ireland between the years 1993 to 1997. There has been a dramatic decrease in the incidence of the Sudden Infant Death Syndrome (SIDS) in the Republic of Ireland in the last decade from an average rate of 2.2\\/1000 live-births in the 1980s to 0.8\\/1000 live-births in the years 1993-1997, a decrease of 100 deaths a year. The fall in the SIDS rate has been seen in many countries and is felt to be associated with Reduce The Risks (RTR) of SIDS campaigns and the avoidance of the prone sleeping position. The use of the prone sleep position averaged at 6% of children being put prone in the years 1993-1997 but the prone position has progressively decreased from 13% of children being put prone in 1994 to only 2% in 1997. The profile of the Irish SIDS cases is similar to that of SIDS cases in other countries following similar RTR campaigns with a male predominance, the characteristic clustering of deaths in the first six months of life and the majority of cases (75%) occuring in the night sleep period. The loss of the seasonal variation of the time of death is also shown and factors such as lower socio-economic status, unemployment and medical card eligibility were seen in higher proportions in SIDS families than in the general population. A high percentage of SIDS mothers smoked (73%). Higher smoking rates were seen among younger and single mothers and smoking rates were inversely related to educational level and socioeconomic grouping. An urgent question that needs to be addressed is how socioeconomic disadvantage increases the SIDS risk and what factors influence socioeconomically disadvantaged families to adopt life style and parenting practices such as smoking that influence their children\\'s health.

  16. Societal costs of multiple sclerosis in Ireland. (United States)

    Carney, Peter; O'Boyle, Derek; Larkin, Aidan; McGuigan, Christopher; O'Rourke, Killian


    This paper evaluates the impact of multiple sclerosis (MS) in Ireland, and estimates the associated direct, indirect, and intangible costs to society based on a large nationally representative sample. A questionnaire was developed to capture the demographics, disease characteristics, healthcare use, informal care, employment, and wellbeing. Referencing international studies, standardized survey instruments were included (e.g. CSRI, MFIS-5, EQ-5D) or adapted (EDSS) for inclusion in an online survey platform. Recruitment was directed at people with MS via the MS Society mailing list and social media platforms, as well as in traditional media. The economic costing was primarily conducted using a 'bottom-up' methodology, and national estimates were achieved using 'prevalence-based' extrapolation. A total of 594 people completed the survey in full. The sample had geographic, disease, and demographic characteristics indicating good representativeness. At an individual level, average societal cost was estimated at €47,683; the average annual costs for those with mild, moderate, and severe MS were calculated as €34,942, €57,857, and €100,554, respectively. For a total Irish MS population of 9,000, the total societal costs of MS amounted to €429m. Direct costs accounted for just 30% of the total societal costs, indirect costs amounted to 50% of the total, and intangible or QoL costs represented 20%. The societal cost associated with a relapse in the sample is estimated as €2,438. The findings highlight that up to 70% of the total costs associated with MS are not routinely counted. These "hidden" costs are higher in Ireland than the rest of Europe, due in part to significantly lower levels of workforce participation, a higher likelihood of permanent workforce withdrawal, and higher levels of informal care needs. The relationship between disease progression and costs emphasize the societal importance of managing and slowing the progression of the illness.

  17. The current epidemiology of SIDS in Ireland. (United States)

    Mehanni, M; Cullen, A; Kiberd, B; McDonnell, M; O'Regan, M; Matthews, T


    This paper examines some epidemiological factors associated with SIDS to give a general profile of SIDS cases occurring in Ireland between the years 1993 to 1997. There has been a dramatic decrease in the incidence of the Sudden Infant Death Syndrome (SIDS) in the Republic of Ireland in the last decade from an average rate of 2.2/1000 live-births in the 1980s to 0.8/1000 live-births in the years 1993-1997, a decrease of 100 deaths a year. The fall in the SIDS rate has been seen in many countries and is felt to be associated with Reduce The Risks (RTR) of SIDS campaigns and the avoidance of the prone sleeping position. The use of the prone sleep position averaged at 6% of children being put prone in the years 1993-1997 but the prone position has progressively decreased from 13% of children being put prone in 1994 to only 2% in 1997. The profile of the Irish SIDS cases is similar to that of SIDS cases in other countries following similar RTR campaigns with a male predominance, the characteristic clustering of deaths in the first six months of life and the majority of cases (75%) occuring in the night sleep period. The loss of the seasonal variation of the time of death is also shown and factors such as lower socio-economic status, unemployment and medical card eligibility were seen in higher proportions in SIDS families than in the general population. A high percentage of SIDS mothers smoked (73%). Higher smoking rates were seen among younger and single mothers and smoking rates were inversely related to educational level and socioeconomic grouping. An urgent question that needs to be addressed is how socioeconomic disadvantage increases the SIDS risk and what factors influence socioeconomically disadvantaged families to adopt life style and parenting practices such as smoking that influence their children's health.

  18. Alcohol use among amateur sportsmen in Ireland

    Directory of Open Access Journals (Sweden)

    Kenny Susan C


    Full Text Available Abstract Background The objective of this study was to establish baseline data on alcohol consumption patterns, behaviours and harms among amateur sportsmen in the Republic of Ireland. Findings The study presents findings from the baseline survey for a cluster randomised controlled trial to evaluate the effectiveness of a community intervention programme to reduce problem alcohol use among a representative sample of Gaelic Athletic Association (GAA clubs in two counties in the Republic of Ireland. Self reported alcohol use, prevalence of binge drinking, AUDIT scores and alcohol-related harms were assessed in amateur GAA sportsmen aged 16 years and over. Nine hundred and sixty (960 players completed questionnaires (72% response rate. Mean age was 24.0 years (S.D. 5.2. Of those aged 18 years or over, 75% had post-primary education; most (864, 90% were current drinkers and 8.2% were regular smokers. The self-reported average yearly alcohol consumption was 12.5 litres. Almost one third (31% of current drinkers reported drinking over the recommended limit of 21 standard drinks per week and just over half (54.3% reported drinking 6 or more standard drinks in a row at least once a week (regular binge drinking. Of those who (self completed the Alcohol Use Disorder Identification Test (AUDIT questionnaire, three-quarters (74.7% had a score of 8 or more; 11.5% had a score of 20 or above warranting referral for diagnostic evaluation and treatment. Almost all (87.6% of the 864 drinkers reported experiencing at least one harm due to their drinking. These alcohol misuse outcomes were higher than those found in a nationally representative sample of males of a similar age. There were strong associations between regular binge drinking and reporting harms such as being in a fight (adjusted odds ratio (OR 2.02, p Conclusions These male amateur sportsmen reported high rates of alcohol consumption and alcohol-related harm.

  19. Pricing and reimbursement of drugs in Ireland. (United States)

    Barry, Michael; Tilson, Lesley; Ryan, Máirín


    Expenditure on healthcare in Ireland, which is mainly derived from taxation, has increased considerably in recent years to an estimated 9.2 billion euro in 2003. Pharmaceuticals account for approximately 10% of total healthcare expenditure. Approximately one-third of patients receive their medications free of charge whilst the remaining two-thirds are subject to a co-payment threshold of 78 euro per month, i.e. 936 euro per year. The price of medications in Ireland is linked to those of five other member states where the price to the wholesaler of any medication will not exceed the lesser of the currency-adjusted wholesale price in the United Kingdom or the average of wholesale prices in Denmark, France, Germany, The Netherlands and the United Kingdom. A price freeze at the introduction price has been in existence since 1993. Despite the price freeze, expenditure on medicines on the community drugs scheme has increased from 201 million euro in 1993 to 898 million euro in 2002. The two main factors contributing to the increased expenditure on medicines include "product mix", the prescribing of new and more expensive medication, and "volume effect" comprising growth in the number of prescription items. Changing demographics and the extension of the General Medical Services (GMS) Scheme to provide free medicines for all those over the age of 70 years have also contributed. Prior to reimbursement under the community drugs schemes, a medicine must be included in the GMS code book or positive list. A demonstration of cost-effectiveness is not a pre-requisite for reimbursement.

  20. "Managed competition" for Ireland? The single versus multiple payer debate.

    LENUS (Irish Health Repository)

    Mikkers, Misja


    A persistent feature of international health policy debate is whether a single-payer or multiple-payer system can offer superior performance. In Ireland, a major reform proposal is the introduction of \\'managed competition\\' based on the recent reforms in the Netherlands, which would replace many functions of Ireland\\'s public payer with a system of competing health insurers from 2016. This article debates whether Ireland meets the preconditions for effective managed competition, and whether the government should implement the reform according to its stated timeline. We support our arguments by discussing the functioning of the Dutch and Irish systems.

  1. Poles Living in Ireland and their Quality of Life

    Directory of Open Access Journals (Sweden)

    Agnieszka NOLKA


    Full Text Available The economic growth of Ireland resulted in a significant number of Poles migrating to Ireland following the EU enlargement in 2004. The article explores the quality of life of Poles living in Ireland. Using data from a preliminary survey conducted in 2006, several dimensions of living conditions are analysed, including interpersonal relations, material security, health and healthcare. The study shows that evaluations of almost all aspects of quality of life improved, apart from components such as healthcare and the ability to acquire help from social organisations. Also interpersonal relations, contrary to the initial assumption, were enhanced by migration to Ireland.

  2. International trends in health science librarianship Part 8: the UK and the Republic of Ireland Northern Ireland. (United States)

    Latimer, Karen; Lawton, Aoife


    This is the 8th in a series of articles exploring international trends in health science librarianship with a focus on the UK and Ireland in the first decade of the 21st century. The invited authors are from Northern Ireland and the Republic of Ireland. Future issues will track trends from Scotland and Wales. © 2013 The authors. Health Information and Libraries Journal © 2013 Health Libraries Group.

  3. Renewables integration, flexibility measures and operational tools for the Ireland and Northern Ireland power system

    International Nuclear Information System (INIS)

    Flynn, Damian; Power, Michael; O'Malley, Mark


    The Ireland and Northern Ireland power system is pursuing ambitious renewable energy (mainly wind generation) targets for 2020. A range of system-wide initiatives are being developed as part of the DS3 (Delivering a Secure, Sustainable Electricity System) programme, and, in particular, a bespoke suite of ancillary services incentivising fast frequency response, dynamic reactive power and ramping margin, and other, (future) system needs. With approximately half of the wind generation connected at distribution level, network development at both distribution and transmission levels is a key challenge for both the transmission system operators (TSO) and distribution system operators (DSO): a wide range of technical options are being examined, including under-grounding, HVDC connection and series compensation, supported by a public and stakeholder engagement programme. The experience gained is highlighted, while also indicating solutions and strategies which have been proposed, and ongoing challenges for the future. (Authors)

  4. Pharmacological Treatment for Atrial Fibrillation

    Directory of Open Access Journals (Sweden)

    Kaoru Sugi, MD PhD


    Full Text Available Pharmacological treatment for atrial fibrillation has a variety of purposes, such as pharmacological defibrillation, maintenance of sinus rhythm, heart rate control to prevent congestive heart failure and prevention of both cerebral infarction and atrial remodeling. Sodium channel blockers are superior to potassium channel blockers for atrial defibrillation, while both sodium and potassium channel blockers are effective in the maintenance of sinus rhythm. In general, digitalis or Ca antagonists are used to control heart rate during atrial fibrillation to prevent congestive heart failure, while amiodarone or bepridil also reduce heart rates during atrial fibrillation. Anticoagulant therapy with warfarin is recommended to prevent cerebral infarction and angiotensin converting enzyme antagonists or angiotensin II receptor blockers are also used to prevent atrial remodeling. One should select appropriate drugs for treatment of atrial fibrillation according to the patient's condition.

  5. Pharmacological challenges in chronic pancreatitis


    Olesen, Anne Estrup; Brokjaer, Anne; Fisher, Iben Wendelboe; Larsen, Isabelle Myriam


    Drug absorption in patients with chronic pancreatitis might be affected by the pathophysiology of the disease. The exocrine pancreatic insufficiency is associated with changes in gastrointestinal intraluminal pH, motility disorder, bacterial overgrowth and changed pancreatic gland secretion. Together these factors can result in malabsorption and may also affect the efficacy of pharmacological intervention. The lifestyle of chronic pancreatitis patients may also contribute to gastrointestinal ...

  6. Applications of stable isotopes in clinical pharmacology

    NARCIS (Netherlands)

    Schellekens, Reinout C A; Stellaard, Frans; Woerdenbag, Herman J; Frijlink, Henderik W; Kosterink, Jos G W


    This review aims to present an overview of the application of stable isotope technology in clinical pharmacology. Three main categories of stable isotope technology can be distinguished in clinical pharmacology. Firstly, it is applied in the assessment of drug pharmacology to determine the

  7. The Castleisland radon Survey (Sw Ireland)

    Energy Technology Data Exchange (ETDEWEB)

    Organo, C. [Radiological Protection Institute of Ireland, Dublin (Ireland); O' sullivan, F. [London Univ. College, Dept of Geomatic Engineering, London, (United Kingdom)


    Full text: In September 2003, following the identification of a house near Castleisland in County Kerry (Sw Ireland) with a seasonally adjusted annual average radon concentration of 49,000 Bq/m{sup 3}, the Radiological Protection of Ireland (R.P.I.I.) undertook to carry out a localised radon survey, the so-called 'Castleisland Radon Survey' (C.R.S.). The aim was to investigate the possibility that similarly extreme radon concentrations could be present in other houses in the surrounding area. A studied area of 400 km{sup 2} was designated around the town of Castleisland, divided in four 10 x 10 km{sup 2} grid squares, and all of the approximately 2,500 householders living in this area were invited to participate. Four hundred and eighteen householders responded to the invitation (17% response rate) but only 383 completed the survey. Fourteen percent of these 383 homes were found to have an annual average radon concentration above the Irish national Reference Level for domestic dwellings of 200 Bq/m{sup 3} while 2% were found to be above 800 Bq/m{sup 3}. An arithmetic mean of 147 Bq/m{sup 3} and a geometric mean of 70 Bq/m{sup 3} were calculated for the four studied grid squares. These can be compared with the respective values of 98 and 56 Bq/m3 calculated for the same area by the Irish National Radon Survey (N.R.S.). Similar trends are observed on a grid square by grid square basis where in one of them in particular, the C.R.S. allowed us to predict that 21% of all houses would have radon concentrations in excess of 200 Bq/m{sup 3}, against 6% predicted by the N.R.S.. This clearly indicates that the extent of the radon problem in the area has been underestimated by the N.R.S.. Two of the four grid squares investigated are currently designated as High Radon Areas (where 10% or more of all houses are predicted to exceed 200 Bq/m{sup 3}) based on the results from the N.R.S.. If one was to use predictions based on the results from the C.R.S., all four grid

  8. Dietary behaviour and health in Northern Ireland: an exploration of biochemical and haematological associations.


    Barker, M E; McClean, S I; Strain, J J; Thompson, K A


    STUDY OBJECTIVE--The aim was to determine the relationships between dietary behaviour and biochemical and haematological measures. DESIGN--This was a cross sectional population study. SETTING--The study took place in the general community within Northern Ireland. SUBJECTS--522 randomly selected adults aged 18-64 years took part (65% of the eligible sample). MEASUREMENTS AND MAIN RESULTS--Four dietary behaviours were identified using principal components analysis from 7 d weighed dietary recor...

  9. Alcohol use among amateur sportsmen in Ireland.

    LENUS (Irish Health Repository)

    O'Farrell, Anne M


    ABSTRACT: BACKGROUND: The objective of this study was to establish baseline data on alcohol consumption patterns, behaviours and harms among amateur sportsmen in the Republic of Ireland. FINDINGS: The study presents findings from the baseline survey for a cluster randomised controlled trial to evaluate the effectiveness of a community intervention programme to reduce problem alcohol use among a representative sample of Gaelic Athletic Association (GAA) clubs in two counties in the Republic of Ireland. Self reported alcohol use, prevalence of binge drinking, AUDIT scores and alcohol-related harms were assessed in amateur GAA sportsmen aged 16 years and over. Nine hundred and sixty (960) players completed questionnaires (72% response rate). Mean age was 24.0 years (S.D. 5.2). Of those aged 18 years or over, 75% had post-primary education; most (864, 90%) were current drinkers and 8.2% were regular smokers. The self-reported average yearly alcohol consumption was 12.5 litres. Almost one third (31%) of current drinkers reported drinking over the recommended limit of 21 standard drinks per week and just over half (54.3 %) reported drinking 6 or more standard drinks in a row at least once a week (regular binge drinking). Of those who (self) completed the Alcohol Use Disorder Identification Test (AUDIT) questionnaire, three-quarters (74.7%) had a score of 8 or more; 11.5% had a score of 20 or above warranting referral for diagnostic evaluation and treatment. Almost all (87.6%) of the 864 drinkers reported experiencing at least one harm due to their drinking. These alcohol misuse outcomes were higher than those found in a nationally representative sample of males of a similar age. There were strong associations between regular binge drinking and reporting harms such as being in a fight (adjusted odds ratio (OR) 2.02, p<0.001), missing time from work or college (adjusted OR 1.39, p=0.04) or being in an accident (adjusted OR 1.78, p=0.04). CONCLUSIONS: These male amateur

  10. Radiological Protection Institute of Ireland Strategic Plan 2008 to 2010

    International Nuclear Information System (INIS)


    The RPII recognises that Ireland is now entering a time of transition and change, with many uncertain variables in economic and environmental issues emerging. Against this background, this strategy document seeks to ensure that the high level of radiation protection that already exists in Ireland is sustained and built upon over the next three years

  11. Sexually transmitted infection incidence among adolescents in Ireland.

    LENUS (Irish Health Repository)

    Davoren, Martin P


    The burden of sexually transmitted infections (STIs) rests with young people, yet in Ireland there has been very little research into this population. The purpose of this study was to determine the incidence rate and establish risk factors that predict STI occurrence among adolescents in Ireland.

  12. Ireland's South African War 1899–1902 | Diver | Scientia Militaria ...

    African Journals Online (AJOL)

    The dearth in research is perhaps due to Irish Nationalist historiography and sensitivity during the twentieth century, which has arguably distorted our perspective of Ireland's shared history with the British Empire. Therefore, it is the purpose of this article to present an alternative Ireland, which has largely been ignored, ...

  13. Family and Family Change in Ireland: An Overview (United States)

    Canavan, John


    In Ireland, historically and in the current era, family has been a central concern for society and the State. This article provides a descriptive overview of family life in Ireland and of major family-related changes over the past 40 years. It presents a general framework of analysis within which these changes can be understood, considers the…

  14. Pharmacological chaperoning: a primer on mechanism and pharmacology. (United States)

    Leidenheimer, Nancy J; Ryder, Katelyn G


    Approximately forty percent of diseases are attributable to protein misfolding, including those for which genetic mutation produces misfolding mutants. Intriguingly, many of these mutants are not terminally misfolded since native-like folding, and subsequent trafficking to functional locations, can be induced by target-specific, small molecules variably termed pharmacological chaperones, pharmacoperones, or pharmacochaperones (PCs). PC targets include enzymes, receptors, transporters, and ion channels, revealing the breadth of proteins that can be engaged by ligand-assisted folding. The purpose of this review is to provide an integrated primer of the diverse mechanisms and pharmacology of PCs. In this regard, we examine the structural mechanisms that underlie PC rescue of misfolding mutants, including the ability of PCs to act as surrogates for defective intramolecular interactions and, at the intermolecular level, overcome oligomerization deficiencies and dominant negative effects, as well as influence the subunit stoichiometry of heteropentameric receptors. Not surprisingly, PC-mediated structural correction of misfolding mutants normalizes interactions with molecular chaperones that participate in protein quality control and forward-trafficking. A variety of small molecules have proven to be efficacious PCs and the advantages and disadvantages of employing orthostatic antagonists, active-site inhibitors, orthostatic agonists, and allosteric modulator PCs are considered. Also examined is the possibility that several therapeutic agents may have unrecognized activity as PCs, and this chaperoning activity may mediate/contribute to therapeutic action and/or account for adverse effects. Lastly, we explore evidence that pharmacological chaperoning exploits intrinsic ligand-assisted folding mechanisms. Given the widespread applicability of PC rescue of mutants associated with protein folding disorders, both in vitro and in vivo, the therapeutic potential of PCs is vast

  15. Nurse teacher stress in Northern Ireland. (United States)

    Hunter, P; Houghton, D M


    Occupational stress among a 60% sample of all nurse tutors in Northern Ireland was investigated by means of the General Health Questionnaire (GHQ), Maslach Burnout Inventory and a stress questionnaire. Seventy per cent of tutors judged themselves to be worse or much worse than usual on 45% of GHQ items. Significant levels of moderate and high burnout were discovered on the sub-scales of emotional exhaustion and depersonalization, with an almost unanimous (95%) report of high burnout arising out of feelings of lack of personal accomplishment. Male nurse tutors reported more frequent and more intense signs of burnout than their female counterparts at a statistically significant level of difference in emotional exhaustion (P = 0.028 and P = 0.003 respectively) and in depersonalization (P work stressor most commonly identified by tutors (72%) was that of experiencing too little time to perform their duties to their satisfaction. The most common request for help to alleviate workplace stress (61%) was for more support and appreciation from their seniors.

  16. Hepatitis E Virus (HEV) Infection in Ireland

    LENUS (Irish Health Repository)

    Hickey, C


    Hepatitis E virus (HEV) is a single stranded RNA virus causing infection worldwide. In developing countries HEV genotypes 1 and 2 spread faeco-orally via water. Recently, infections with HEV have been detected in Europe and North America in patients with no travel history. These are food-borne HEV genotypes 3 and 4, a pig-associated zoonosis. Most infections are asymptomatic but morbidity and chronic infection may occur with prior liver disease or immunosuppression. International seroprevalence rates vary and with improved diagnostics have increased. To determine the current prevalence in this region we studied anonymised serum samples submitted in 2015 for routine testing. We detected anti-HEV IgG in 16\\/198 (8%) individuals, highest rate in 40-59 year olds (43.8%). This is higher than reported for the same region in 1995 (0.4%) using a previous generation assay. This study provides evidence of HEV circulation in Ireland and reinforces the need for ongoing surveillance.

  17. Carbon monoxide measurements at Mace Head, Ireland (United States)

    Doddridge, Bruce G.; Dickerson, Russell R.; Spain, T. Gerard; Oltmans, Samuel J.; Novelli, Paul C.


    The North Atlantic Ocean is bordered by continents which may each, under the influence of seasonal weather patterns, act as sources of natural and anthropogenic trace gas and particulate species. Photochemically active species such as carbon monoxide (CO) react to form ozone (O3), a species of critical importance in global climate change. CO is sparingly soluble in water, and the relatively long lifetime of CO in the troposphere makes this species an ideal tracer of air masses with origin over land. We have measured CO using a nondispersive infrared gas filter correlation analyzer at Mace Head on the west coast of Ireland nearly continuously since August 9, 1991. Measurements of CO were acquired at 20-sec resolution and recorded as 60-sec averages. Daily, monthly, and diurnal variation data characteristics of CO mixing ratios observed at this site are reported. Depending on source regions of air parcels passing over this site, 60-min concentrations of CO range from clean air values of approximately 90 ppbv to values in excess of 300 ppbv. Data characterizing the correlation between 60-min CO and O3 mixing ratio data observed at this site are reported also.

  18. CLP activities and control in Ireland

    Directory of Open Access Journals (Sweden)

    Caroline Walsh


    Full Text Available The 10th December 2010 marked a new beginning for Regulation (EC no. 1272/2008 on the classification, labelling and packaging of substances and mixtures (CLP in Ireland with the start of its operational phase. It was on this date that the administrative and enforcement provisions for CLP were encompassed in the new Chemicals Amendment Act, 2010. In this Act, the Health and Safety Authority, known as the "the Authority" is named as Competent Authority (CA for CLP, along with the Minister for Agriculture, Fisheries and Food, in respect of pesticides and plant protection products and the Beaumont Hospital Board with responsibility for receiving information relating to emergency health response. In practice, the Authority has been de facto CA for CLP since its publication on the 31st December 2008, given its role in existing classification and labelling regimes. This article focuses on the work undertaken by the Authority on CLP at a National, European and International level including its implementation, training, helpdesk, guidance, enforcement and awareness raising activities.

  19. Policy analysis: palliative care in Ireland.

    LENUS (Irish Health Repository)

    Larkin, P


    Palliative care for patients with advanced illness is a subject of growing importance in health services, policy and research. In 2001 Ireland became one of the first nations to publish a dedicated national palliative care policy. This paper uses the \\'policy analysis triangle\\' as a framework to examine what the policy entailed, where the key ideas originated, why the policy process was activated, who were the key actors, and what were the main consequences. Although palliative care provision expanded following publication, priorities that were unaddressed or not fully embraced on the national policy agenda are identified. The factors underlying areas of non-fulfilment of policy are then discussed. In particular, the analysis highlights that policy initiatives in a relatively new field of healthcare face a trade-off between ambition and feasibility. Key policy goals could not be realised given the large resource commitments required; the competition for resources from other, better-established healthcare sectors; and challenges in expanding workforce and capacity. Additionally, the inherently cross-sectoral nature of palliative care complicated the co-ordination of support for the policy. Policy initiatives in emerging fields such as palliative care should address carefully feasibility and support in their conception and implementation.

  20. Young Adolescents' Positioning of Human Rights: Findings from Colombia, Northern Ireland, Republic of Ireland and the United States (United States)

    Barton, Keith C.


    This study investigated how young adolescents thought about the location of human rights issues and the nature of violations in differing geographic regions. Open-ended, task-based interviews were conducted with 116 students in Colombia, Northern Ireland, the Republic of Ireland and the United States. Although students in each location pointed to…

  1. Energy drinks available in Ireland: a description of caffeine and sugar content. (United States)

    Keaver, Laura; Gilpin, Susannah; Fernandes da Silva, Joana Caldeira; Buckley, Claire; Foley-Nolan, Cliodhna


    To describe the caffeine and sugar content of all energy drinks available on the island of Ireland. Two retail outlets were selected from each of: multinational, convenience and discount stores in Northern Ireland and the Republic of Ireland, and all available single-serve energy drinks were purchased. The cross-sectional survey was conducted in February 2015 and brand name, price, volume, caffeine and sugar content were recorded for each product. Descriptive analysis was performed. Seventy-eight products were identified on the island of Ireland (regular, n 59; diet/sugar-free/light, n 19). Caffeine and sugar content was in the range of 14-35 mg and 2·9-15·6 g per 100 ml, respectively. Mean caffeine content of 102·2 mg per serving represents 25·6 % of the maximum intake advised for adults by the European Food Safety Authority. Per serving, mean sugar content of regular energy drinks was 37 g. This exceeds WHO recommendations for maximum daily sugar intake of energy intake (25 g for adults consuming 8368 kJ (2000 kcal) diet). If displaying front-of-pack labelling, fifty-seven of the fifty-nine regular energy drinks would receive a Food Standards Agency 'red' colour-coded label for sugar. Energy drinks are freely available on the island of Ireland and all products surveyed can be defined as highly caffeinated products. This has potential health issues particularly for children and adolescents where safe limits of caffeine have not been determined. Energy drinks surveyed also contained high levels of sugar and could potentially contribute to weight gain and adverse dental health effects.

  2. Work-related ill-health: Republic of Ireland, Northern Ireland, Great Britain 2005-2012. (United States)

    Money, A; Carder, M; Noone, P; Bourke, J; Hayes, J; Turner, S; Agius, R


    Data on work-related ill-health (WRIH) in the Republic of Ireland is inconsistent. To compare the incidence of WRIH in the Republic of Ireland (ROI), Northern Ireland (NI) and Great Britain (GB) reported by clinical specialists in skin and respiratory medicine and by specialist occupational physicians (OPs). Analysis of data reported to three surveillance schemes in The Health and Occupation Research (THOR) network in ROI and corresponding UK schemes. Contact dermatitis was the most frequently reported skin disease in the three areas. Asthma was the most frequently-reported respiratory disease in the ROI, while asbestos-related cases predominate in GB and NI. Mental health disorders, followed by musculoskeletal disorders were reported most frequently by OPs. Annual average incidence rates for skin disease were 2 per 100000 employed (95% confidence interval [CI] 1.9-2.8) in the ROI and 7 per 100000 for GB (95% CI 4.8-9.4). Unadjusted incidence rates for respiratory disease were 1 (95% CI 0.3-1) and 8 (95% CI 6.1-10.7) per 100000 in the ROI and GB, respectively; adjusted for reporter non-response, these figures increased to 15 (95% CI 11.3-19.6) and 32 (95% CI 28.4-35.6) per 100000 respectively. This is the first paper to include THOR data on WRIH from the ROI, NI and GB. Consistent and dedicated data collection in the ROI via the THOR schemes is viable and important in the light of a deficit of occupational ill-health data. Sustained efforts to improve participation are underway. © The Author 2014. Published by Oxford University Press on behalf of the Society of Occupational Medicine. All rights reserved. For Permissions, please email:

  3. Iomazenil: pharmacological and animal data

    International Nuclear Information System (INIS)

    Beer, H.F.; Blaeuenstein, P.A.; Hasler, P.H.; Schubiger, P.A.; Hunkeler, W.; Bibettu, E.P.; Pieri, L.; Grayson Richards, J.


    The flumazenil analogue Ro 16-0154 (Iomazenil), a benzodiazepine partial inverse agonist, has been labelled by halogen exchange to enable SPECT investigations of central benzodiazepine receptors in human brain. The purified 123 I-Ro 16-0154 was found to be stable in rat brain preparations and to be metabolized in rat liver preparations. Its pharmacological properties were comparable to those of flumazenil with the exception of the antagonism of diazepam versus pentylenetetrazol. Biodistribution in rats (1 h p.i.) resulted in a high brain to blood ratio of 16. Clinical studies revealed images of the bezodiazepine receptor density in the brain. (author) 9 figs., 3 tabs., 27 refs

  4. Pharmacological approach to acute pancreatitis

    DEFF Research Database (Denmark)

    Bang, U.C.; Semb, S.; Nøjgaard, Camilla


    The aim of the present review is to summarize the current knowledge regarding pharmacological prevention and treatment of acute pancreatitis (AP) based on experimental animal models and clinical trials. Somatostatin (SS) and octreotide inhibit the exocrine production of pancreatic enzymes and may...... be useful as prophylaxis against post endoscopic retrograde cholangiopancreatography pancreatitis (PEP). The protease inhibitor gabexate mesilate (GM) is used routinely as treatment to AP in some countries, but randomized clinical trials and a meta-analysis do not support this practice. Nitroglycerin (NGL...

  5. Pharmacological approach to acute pancreatitis

    DEFF Research Database (Denmark)

    Bang, Ulrich-Christian; Semb, Synne; Nojgaard, Camilla


    -steroidal anti-inflammatory drugs (NSAID) indomethacin and diclofenac have in randomized studies showed potential as prophylaxis against PEP. Interleukin 10 (IL-10) is a cytokine with anti-inflammatory properties but two trials testing IL-10 as prophylaxis to PEP have returned conflicting results. Antibodies...... pharmacological treatment of AP is limited and studies on the effect of potent anti-inflammatory drugs are warranted....... against tumor necrosis factor-alpha (TNF-alpha) have a potential as rescue therapy but no clinical trials are currently being conducted. The antibiotics beta-lactams and quinolones reduce mortality when necrosis is present in pancreas and may also reduce incidence of infected necrosis. Evidence based...

  6. Gaultheria: Phytochemical and Pharmacological Characteristics

    Directory of Open Access Journals (Sweden)

    Ren-Bing Shi


    Full Text Available The genus Gaultheria, comprised of approximately 134 species, is mostly used in ethnic drugs to cure rheumatism and relieve pain. Phytochemical investigations of the genus Gaultheria have revealed the presence of methyl salicylate derivatives, C6-C3 constituents, organic acids, terpenoids, steroids, and other compounds. Methyl salicylate glycoside is considered as a characteristic ingredient in this genus, whose anti-rheumatic effects may have a new mechanism of action. In this review, comprehensive information on the phytochemistry, volatile components and the pharmacology of the genus Gaultheria is provided to explore its potential and advance research.

  7. EWTD compliance amongst Anaesthesia trainees in Ireland. (United States)

    Brohan, J; Moore, D


    The implications of the EWTD include a limit of 48 h working week and 11 consecutive hours rest every 24 h. This survey was designed to assess EWTD compliance over designated 1-week and 1-month periods amongst College of Anaesthesetists of Ireland (CAI) trainees and non-training Anaesthesia NCHDs. The two key elements of EWTD compliance were assessed; the compliance to a 48 h working week, and a minimizing of shift duration to 24 h. Existence of protected training time and teaching time were also assessed. This survey was completed by 191 Anaesthesia NCHDs, including 151 responses from CAI trainees; 75 % response rate from CAI trainees. 71 % of respondents worked in excess of 48 h. 37 % of respondents reported to have worked a shift >24 h duration. The average hours worked was 66 h (range 48.5-103 h). Our figures are a contrast to the reported figures in the HSE "Performance Assurance Report". 49 % of respondents reported a change in their working patterns to facilitate EWTD compliance. There appears to be a negative impact on training however, with 68 % respondents missing departmental teaching sessions and 30 % not receiving protected training time. 33 % of respondents were not in favour of full EWTD compliance. As work patterns change, it is vital to ensure that training is not compromised. Previous reports have recommended an increase in consultant numbers, which has yet to be achieved. This may provide a solution to allow service provision, NCHD training and EWTD compliance amongst NCHDs.

  8. Epidemiological study of soft-tissue sarcomas in Ireland.

    LENUS (Irish Health Repository)

    Bhatt, Nikita


    Soft-tissue sarcomas (STS) account for 1% of adult and 7% of pediatric malignancies. Histopathology and classification of these rare tumors requires further refinements. The aim of this paper is to describe the current incidence and survival of STS from 1994 to 2012 in Ireland and compare these with comparably coded international published reports. This is a retrospective, population study based on the data from the National Cancer Registry of Ireland (NCRI). Incidence and relative survival rates for STS in Ireland were generated. Incidence of STS based on gender, age and anatomical location was examined. Annual mean incidence rate (European Age Standardized) in Ireland between 1994 and 2012 was 4.48 ± 0.15 per 100,000 person-years. The overall relative 5-year survival rate of STS for the period 1994-2011 in Ireland was 56%, which was similar to that reported in the U.K. but lower than in most of Europe and U.S.A. Survival rate fluctuated over the period examined, declining slightly in females but showing an increase in males. STS incidence trends in Ireland were comparable to international reports. Survival trends of STS were significantly different between Ireland and other European countries, requiring further study to understand causation.

  9. Self-Esteem and Self-Efficacy: Associations with Alcohol Consumption in a Sample of Adolescents in Northern Ireland (United States)

    McKay, Michael T.; Sumnall, Harry R.; Cole, Jon C.; Percy, Andrew


    Cross-sectional and longitudinal studies have reported equivocal findings regarding the association between self-esteem, self-efficacy and adolescent alcohol use. Data were collected from a sample of 11-16-year olds in Northern Ireland (n = 4088) over two consecutive academic years measuring global self-esteem, academic, social and emotional…

  10. Pharmacologic therapy for acute pancreatitis (United States)

    Kambhampati, Swetha; Park, Walter; Habtezion, Aida


    While conservative management such as fluid, bowel rest, and antibiotics is the mainstay of current acute pancreatitis management, there is a lot of promise in pharmacologic therapies that target various aspects of the pathogenesis of pancreatitis. Extensive review of preclinical studies, which include assessment of therapies such as anti-secretory agents, protease inhibitors, anti-inflammatory agents, and anti-oxidants are discussed. Many of these studies have shown therapeutic benefit and improved survival in experimental models. Based on available preclinical studies, we discuss potential novel targeted pharmacologic approaches that may offer promise in the treatment of acute pancreatitis. To date a variety of clinical studies have assessed the translational potential of animal model effective experimental therapies and have shown either failure or mixed results in human studies. Despite these discouraging clinical studies, there is a great clinical need and there exist several preclinical effective therapies that await investigation in patients. Better understanding of acute pancreatitis pathophysiology and lessons learned from past clinical studies are likely to offer a great foundation upon which to expand future therapies in acute pancreatitis. PMID:25493000

  11. Ireland or the Netherlands: Which country is more entrepreneurial?


    O'Gorman, Colm; Diaz-Moriana, Vanessa


    What country was ranked the most entrepreneurial of the EU-15 countries in 2005? Ireland. In 2005, Ireland ranked 1st of the EU-15 countries in terms of the rate of entrepreneurship. The Dutch ranked jointed 9th. Which of the EU-15 countries was the most entrepreneurial in 2012? The Netherlands. Since 2005, the rate of entrepreneurship in the Netherlands has increased. They now rank 1stof the EU-15 countries. Ireland’s rate of entrepreneurship has decreased. By 2012, Ireland ranked 9th of the...

  12. Radon in dwellings in Northern Ireland. 1993 review

    International Nuclear Information System (INIS)

    Green, B.; Lomas, P.; O'Riordan, M.


    Measurements of radon made in some 1500 dwellings throughout Northern Ireland by the autumn of 1993 show that the average concentration is 19 Bq m -3 with some values up to fifty times higher. Around 30 of these dwellings are above the Action Level of 200 Bq m -3 adopted by the Government. Data are presented in considerable detail and various forms. Several hundred dwellings in Northern Ireland are estimated to exceed the Action Level, most of which are in a separately designated Affected Area in the southeast. Recommendations are made to promote the discovery and remedy of dwellings above the Action Level throughout Northern Ireland. (author)

  13. Pharmacological and non- pharmacological treatment of hypertension: A review article

    Directory of Open Access Journals (Sweden)

    Marjan Seyedmazhari


    Full Text Available BACKGROUND: Hypertension is a worldwide epidemic disease. It is more common and more severe in elderly persons. Various studies however have estimated 41.9 million men and 27.8 million women to have prehypertension. Diagnosis and early treatment of prehypertension are of utmost importance. Although hypertension is usually divided into 2 general categories of essential (primary and secondary hypertension, the initial treatment for hypertension often depends on its stage which is determined by systolic and diastolic blood pressure. Lifestyle modification is the first step in treating stage one hypertension. Pharmaceutical treatments including diuretics, angiotensin converting enzyme (ACE inhibitors, calcium blockers, beta blockers, and angiotensin receptor blockers will be recommended if lifestyle modification fails to control blood pressure.    METHODS: The PubMed database was searched by a number of keywords including hypertension, pharmaceutical treatment, and non-pharmaceutical treatment. The results were limited by determining a date range of 2008-11.    RESULTS: High blood pressure causes major health problems for many people around the world. It should be controlled because of its high mortality and morbidity. However, in order to select an appropriate treatment modality, it is initially important to diagnose the kinds and stages of hypertension. Pharmaceutical or non-pharmaceutical treatments can then be employed to control this serious disease.    CONCLUSION: Treating hypertension depends on the kinds and stages of this disease. Several tips should be considered when selecting a method of treatment.       Keywords: Hypertension, Pharmacological treatment, Non-pharmacological treatment

  14. Caries status in 16 year-olds with varying exposure to water fluoridation in Ireland.

    LENUS (Irish Health Repository)

    Mullen, J


    Most of the Republic of Ireland\\'s public water supplies have been fluoridated since the mid-1960s while Northern Ireland has never been fluoridated, apart from some small short-lived schemes in east Ulster.

  15. Ireland, Shaded Relief and Colored Height (United States)


    The island of Ireland comprises a large central lowland of limestone with a relief of hills surrounded by a discontinuous border of coastal mountains which vary greatly in geological structure. The mountain ridges of the south are composed of old red sandstone separated by limestone river valleys. Granite predominates in the mountains of Galway, Mayo and Donegal in the west and north-west and in Counties Down and Wicklow on the east coast, while a basalt plateau covers much of the north-east of the country. The central plain, which is broken in places by low hills, is extensively covered with glacial deposits of clay and sand. It has considerable areas of bog and numerous lakes. The island has seen at least two general glaciations and everywhere ice-smoothed rock, mountain lakes, glacial valleys and deposits of glacial sand, gravel and clay mark the passage of the ice. Two visualization methods were combined to produce this image: shading and color coding of topographic height. The shade image was derived by computing topographic slope in the northwest-southeast direction, so that northwest slopes appear bright and southeast slopes appear dark. Color coding is directly related to topographic height, with green at the lower elevations, rising through yellow and tan, to white at the highest elevations. Elevation data used in this image were acquired by the Shuttle Radar Topography Mission aboard the Space Shuttle Endeavour, launched on Feb. 11, 2000. SRTM used the same radar instrument that comprised the Spaceborne Imaging Radar-C/X-Band Synthetic Aperture Radar (SIR-C/X-SAR) that flew twice on the Space Shuttle Endeavour in 1994. SRTM was designed to collect 3-D measurements of the Earth's surface. To collect the 3-D data, engineers added a 60-meter (approximately 200-foot) mast, installed additional C-band and X-band antennas, and improved tracking and navigation devices. The mission is a cooperative project between NASA, the National Geospatial-Intelligence Agency

  16. Ethnobotany, phytochemistry, and pharmacology of the genus Litsea: An update. (United States)

    Wang, Yun-Song; Wen, Zheng-Qi; Li, Bi-Tao; Zhang, Hong-Bin; Yang, Jing-Hua


    modern pharmacology research. Deep and systematic phytochemical investigation of the genus Litsea and the pharmacological properties, especially its mechanism of action and toxicology, to illustrate its ethnomedicinal use, explore the therapeutic potential and support further health-care product development will undoubtedly be the focus of further research. Therefore, detailed and extensive studies and clinical evaluation of Litsea species should be carried out in future for the safety approval of therapeutic applications. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  17. The first prospective injury audit of League of Ireland footballers (United States)

    Fitzharris, Nigel; Jones, Ashley; Francis, Peter


    Objectives Football has the highest sports participation (10.6%) in Ireland ahead of its Gaelic counterpart (3.9%). Research into injury incidence and patterns in Irish football is non-existent. The aim of this study was to conduct a prospective injury audit of League of Ireland (semiprofessional) footballers during the 2014 season (8 months, 28 games). Methods A total of 140 semiprofessional League of Ireland footballers were prospectively followed between March and November 2014. Data were collected in accordance with the international consensus on football injury epidemiology. Results The injury rate was 9.2/1000 hour exposure to football (95% CI 6.2 to 12.9, pLeague of Ireland football is similar to that of European professional football, although the incidence of injury is higher. The incidence of injury is in line with that of Dutch amateur football. PMID:29071112

  18. Pharmacoeconomic evaluation in Ireland: A review of the process

    LENUS (Irish Health Repository)

    Tilson, Lesley


    The aim of this review is to describe the pharmacoeconomic assessment process in Ireland and to provide examples of recent appraisals and the subsequent impact on pricing and reimbursement decisions.\\r\

  19. Squaring the Circle: Attempting Peace in Northern Ireland

    National Research Council Canada - National Science Library

    Marchi, Gina


    Finding a political framework for self-government in Northern Ireland that will be supported by both nationalists and unionists is referred to as a modern day attempt to do the impossible-to 'square the circle...

  20. Poisonings and clinical toxicology: a template for Ireland.

    LENUS (Irish Health Repository)

    Tormey, W P


    Poisons information is accessed around the clock in the British Isles from six centres of which two are in Ireland at Dublin and Belfast accompanied by consultant toxicologist advisory service. The numbers of calls in Ireland are down to about 40 per day due to easy access to online data bases. Access to Toxbase, the clinical toxicology database of the National Poisons Information Service is available to National Health Service (NHS) health professionals and to Emergency Departments and Intensive Care units in the Republic of Ireland. There are 59 Toxbase users in the Republic of Ireland and 99 % of activity originates in Emergency Departments. All United States Poison Control Centres primarily use Poisindex which is a commercial database from Thomson Reuters.

  1. Review: Questioning Ireland: debates in political philosophy and public policy


    Sheehan, Helena


    This is a review of a collection of essays entitled Questioning Ireland: debates in political philosophy and public policy, edited by Joseph Dunne, Attracta Ingram and Frank Litton, published in Dublin by the Institute of Public Administration in 2000.

  2. Ireland and immigration: explaining the absence of the far right


    Garner, Steve


    This article seeks to explain the absence of far-right political formations in the history of the Republic of Ireland, especially in relation to immigration. I argue that the ‘mainstream’ nationalist parties have implemented a racialized governance of Ireland via the issue of citizenship (in the referendum of 2004). While hegemonic ideas on the racial purity of indigenous populations and the highly ambivalent attitudes and policies on immigration pursued over the last decade are characteristi...

  3. Export marketing strategies for the Northern Ireland seed potato industry


    Lamont, Jeffrey


    This thesis is concerned primarily with the export marketing performance of the Northern Ireland seed potato industry. The Industry has shown a dramatic decline in exports over the past twenty years, and this thesis proposes strategies aimed at regaining, and maintaining, a competitive advantage for the industry in world markets. A comparative analysis is conducted of the strategic and organisational export capabilities of the Northern Ireland industry and its main compet...

  4. Is fuel poverty in Ireland a distinct type of deprivation?


    Watson, Dorothy; Maitre, Bertrand


    In this paper, we draw on the Central Statistics Office SILC data for Ireland to ask whether fuel poverty is a distinctive type of deprivation that warrants a fundamentally different policy response than poverty in general. We examine the overlap between fuel poverty (based on three self-report items) and poverty in general – with a particular emphasis on the national indicator of basic deprivation which is used in the measurement of poverty for policy purposes in Ireland. We examine changes ...

  5. Estimating the economic cost of disability in Ireland


    Cullinan, John; Gannon, Brenda; Lyons, Seán


    Addressing the extra economic costs of disability seems a logical step towards alleviating elements of social exclusion for people with disabilities. This paper estimates the economic cost of disability in Ireland in terms of the additional spending needs that arise due to disability. It defines and estimates models of the private costs borne by families with individuals who have a disability in Ireland when compared to the wider population, both in general and by severity of illness. Our mod...

  6. Pertussis outbreak in northwest Ireland, January - June 2010.

    LENUS (Irish Health Repository)

    Barret, A S


    We report a community pertussis outbreak that occurred in a small town located in the northwest of Ireland. Epidemiological investigations suggest that waning immunity and the absence of a booster dose during the second year of life could have contributed to the outbreak. The report also highlights the need to reinforce the surveillance of pertussis in Ireland and especially to improve the clinical and laboratory diagnosis of cases.

  7. Pharmacological challenges in chronic pancreatitis

    DEFF Research Database (Denmark)

    Olesen, Anne Estrup; Brokjaer, Anne; Fischer, Iben Wendelboe Deleuran


    food intake is more or less substituted with alcohol, tobacco and coffee. Alcohol and drug interaction are known to influence the pharmacokinetics by altering either drug absorption or by affecting liver metabolism. Since patients suffering from chronic pancreatitis experience severe pain, opioids......Drug absorption in patients with chronic pancreatitis might be affected by the pathophysiology of the disease. The exocrine pancreatic insufficiency is associated with changes in gastrointestinal intraluminal pH, motility disorder, bacterial overgrowth and changed pancreatic gland secretion....... Together these factors can result in malabsorption and may also affect the efficacy of pharmacological intervention. The lifestyle of chronic pancreatitis patients may also contribute to gastrointestinal changes. Many patients limit their food intake because of the pain caused by eating and in some cases...

  8. Pharmacological challenges in chronic pancreatitis

    DEFF Research Database (Denmark)

    Olesen, Anne Estrup; Brokjaer, Anne; Fischer, Iben Wendelboe Deleuran


    food intake is more or less substituted with alcohol, tobacco and coffee. Alcohol and drug interaction are known to influence the pharmacokinetics by altering either drug absorption or by affecting liver metabolism. Since patients suffering from chronic pancreatitis experience severe pain, opioids....... Together these factors can result in malabsorption and may also affect the efficacy of pharmacological intervention. The lifestyle of chronic pancreatitis patients may also contribute to gastrointestinal changes. Many patients limit their food intake because of the pain caused by eating and in some cases......Drug absorption in patients with chronic pancreatitis might be affected by the pathophysiology of the disease. The exocrine pancreatic insufficiency is associated with changes in gastrointestinal intraluminal pH, motility disorder, bacterial overgrowth and changed pancreatic gland secretion...

  9. Pharmacology of human experimental anxiety

    Directory of Open Access Journals (Sweden)

    F.G. Graeff


    Full Text Available This review covers the effect of drugs affecting anxiety using four psychological procedures for inducing experimental anxiety applied to healthy volunteers and patients with anxiety disorders. The first is aversive conditioning of the skin conductance responses to tones. The second is simulated public speaking, which consists of speaking in front of a video camera, with anxiety being measured with psychometric scales. The third is the Stroop Color-Word test, in which words naming colors are painted in the same or in a different shade, the incongruence generating a cognitive conflict. The last test is a human version of a thoroughly studied animal model of anxiety, fear-potentiated startle, in which the eye-blink reflex to a loud noise is recorded. The evidence reviewed led to the conclusion that the aversive conditioning and potentiated startle tests are based on classical conditioning of anticipatory anxiety. Their sensitivity to benzodiazepine anxiolytics suggests that these models generate an emotional state related to generalized anxiety disorder. On the other hand, the increase in anxiety determined by simulated public speaking is resistant to benzodiazepines and sensitive to drugs affecting serotonergic neurotransmission. This pharmacological profile, together with epidemiological evidence indicating its widespread prevalence, suggests that the emotional state generated by public speaking represents a species-specific response that may be related to social phobia and panic disorder. Because of scant pharmacological data, the status of the Stroop Color-Word test remains uncertain. In spite of ethical and economic constraints, human experimental anxiety constitutes a valuable tool for the study of the pathophysiology of anxiety disorders.

  10. An overview of cleaner fish use in Ireland. (United States)

    Bolton-Warberg, M


    Sea lice infestations represent one of the most significant challenges facing the salmon farming industry, giving rise to lost production, additional costs of treatment and potential negative interactions with wild stocks. At present, cleaner fish, which actively remove lice from salmon, are an effective, biological, long-term option which has been adopted by many countries. In Ireland, several key studies were conducted in the 1990s on the use of wild-caught wrasse (corkwing, goldsinny and rock cook) as cleaner fish in experimental and commercial scale trials. More recently, the National University of Ireland Galway (NUIG), at their marine research facility in Carna (CRS), has undertaken applied research on ballan wrasse and lumpsucker. Currently, CRS is providing lumpsucker juveniles and research and development for the Irish salmon industry with support from BIM (Ireland's Seafood Development Agency) and Marine Harvest Ireland. There is a large amount of research currently being carried out in this area in all countries that are utilizing cleaner fish technology. The current focus in Ireland is the development of a native lumpsucker broodstock to facilitate its sustainable production. The aim of this article was to provide an overview of the research, challenges and use of cleaner fish in Ireland. © 2017 The Authors Journal of Fish Diseases Published by John Wiley & Sons Ltd.

  11. Systems pharmacology-based drug discovery for marine resources: an example using sea cucumber (Holothurians). (United States)

    Guo, Yingying; Ding, Yan; Xu, Feifei; Liu, Baoyue; Kou, Zinong; Xiao, Wei; Zhu, Jingbo


    Sea cucumber, a kind of marine animal, have long been utilized as tonic and traditional remedies in the Middle East and Asia because of its effectiveness against hypertension, asthma, rheumatism, cuts and burns, impotence, and constipation. In this study, an overall study performed on sea cucumber was used as an example to show drug discovery from marine resource by using systems pharmacology model. The value of marine natural resources has been extensively considered because these resources can be potentially used to treat and prevent human diseases. However, the discovery of drugs from oceans is difficult, because of complex environments in terms of composition and active mechanisms. Thus, a comprehensive systems approach which could discover active constituents and their targets from marine resource, understand the biological basis for their pharmacological properties is necessary. In this study, a feasible pharmacological model based on systems pharmacology was established to investigate marine medicine by incorporating active compound screening, target identification, and network and pathway analysis. As a result, 106 candidate components of sea cucumber and 26 potential targets were identified. Furthermore, the functions of sea cucumber in health improvement and disease treatment were elucidated in a holistic way based on the established compound-target and target-disease networks, and incorporated pathways. This study established a novel strategy that could be used to explore specific active mechanisms and discover new drugs from marine sources. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  12. Pharmacologic treatment of depression in multiple sclerosis

    NARCIS (Netherlands)

    Koch, Marcus W.; Glazenborg, Arjon; Uyttenboogaart, Maarten; Mostert, Jop; De Keyser, Jacques


    Background Depression is a common problem in patients with multiple sclerosis (MS). It is unclear which pharmacologic treatment is the most effective and the least harmful. Objectives To investigate the efficacy and tolerability of pharmacologic treatments for depression in patients with MS. Search

  13. Complex Pharmacology of Free Fatty Acid Receptors

    DEFF Research Database (Denmark)

    Milligan, Graeme; Shimpukade, Bharat; Ulven, Trond


    pharmacology have shaped understanding of the complex pharmacology of receptors that recognize and are activated by nonesterified or "free" fatty acids (FFAs). The FFA family of receptors is a recently deorphanized set of GPCRs, the members of which are now receiving substantial interest as novel targets...

  14. The Dutch vision of clinical pharmacology

    NARCIS (Netherlands)

    Schellens, J H M; Grouls, R; Guchelaar, H J; Touw, D J; Rongen, G A; de Boer, A; Van Bortel, L M

    Recent position papers addressing the profession of clinical pharmacology have expressed concerns about the decline of interest in the field among clinicians and medical educators in the United Kingdom and other Western countries, whether clinical pharmacology is actually therapeutics, and whether

  15. Adult orthodontics in the Republic of Ireland: specialist orthodontists' opinions. (United States)

    McMorrow, Siobhán Mary; Millett, Declan T


    To report the opinions of specialist orthodontists regarding the profile, characteristics and treatment of adults currently undergoing orthodontic treatment in the Republic of Ireland (ROI) Design/setting: A national cross-sectional questionnaire study in the ROI. A pilot-tested questionnaire was distributed to 122 specialist orthodontists in the ROI. Questions addressed general and treatment information for current adult orthodontic patients. Those whose treatment involved orthognathic surgery were not excluded. A response of 83% was obtained. Ninety-five per cent of specialists reported treating adults, most of whom were self-referred and were typically professional, female and aged 25-35 years. The overall ratio quoted of professionals to non-professionals was almost 3:2. For 50% of specialists, males were estimated to account for 20-40% of their adult cases and for 23%, this increased to an estimated 40-60%. Class II division 1 malocclusion and skeletal II were considered the most common dentofacial characteristics. Occlusal features encountered in decreasing frequency were generalised crowding, increased overjet, deep overbite, late lower incisor crowding, spacing and impacted teeth. Fifteen per cent reported that at least 10% of their adult cases required orthodontics with maxillofacial surgery but 8% reported that this was at least 50%. Treatment challenges commonly acknowledged were overbite reduction, anchorage management, 'black triangles' and overjet reduction. Tooth whitening was reckoned to be used by 19% of specialists. Aesthetic upper and stainless steel lower brackets were indicated to be used most often whereas only 19% used clear aligners and 10% used lingual appliances often. The profile and characteristics of adults currently undergoing orthodontic treatment in the ROI were diverse. Higher estimates were quoted for self- than for general dental practitioner-referral. A high percentage of treatment was reported to be undertaken for non

  16. INFOMAR, Ireland's National Seabed Mapping Programme; Sharing Valuable Insights. (United States)

    Judge, M. T.; McGrath, F.; Cullen, S.; Verbruggen, K.


    Following the successful high-resolution deep-sea mapping carried out as part of the Irish National Seabed Survey (INSS), a strategic, long term programme was established: INtegrated mapping FOr the sustainable development of Ireland MArine Resources (INFOMAR). Funded by Ireland's Department of Communication, Climate Action and Environment, INFOMAR comprises a multi-platform approach to completing Ireland's marine mapping, and is a key action in the integrated marine plan, Harnessing Our Ocean Wealth. Co-managed by Geological Survey Ireland and the Marine Institute, the programme has three work strands: Data Acquisition; Data Exchange and Integration; Value Added Exploitation.The Data Acquisition strand includes collection of geological, hydrographic, oceanographic, habitat and heritage datasets that underpin sustainable development and management of Ireland's marine resources. INFOMAR operates a free data policy; data and outputs are delivered online through the Data Exchange and Integration strand. Uses of data and outputs are wide-ranging and multipurpose. In order to address the evolution and diversification of user requirements, further data product development is facilitated through the Value Added Exploitation strand.Ninety percent of Ireland's territory lies offshore. Therefore, strategic national seabed mapping continues to provide critical, high-resolution baseline datasets for numerous economic sectors and societal needs. From these we can glean important geodynamic knowledge of Ireland's vast maritime territory. INFOMAR remains aligned with national and European policies and directives. Exemplified by our commitment to EMODnet, a European Commission funded project that supports the collection, standardisation and sharing of available marine information, data and data products across all European Seas. As EMODnet Geology Minerals leaders we have developed a framework for mapping marine minerals. Furthermore, collaboration with the international research

  17. Pharmacology of sexually compulsive behavior. (United States)

    Codispoti, Victoria L


    In a meta-analysis on controlled outcomes evaluations of 22,000 sex offenders, Losel and Schmucker found 80 comparisons between treatment and control groups. The recidivism rate averaged 19% in treated groups, and 27% in controls. Most other reviews reported a lower rate of sexual recidivism in treated sexual offenders. Of 2039 citations in this study (including literature in five languages), 60 studies held independent comparisons. Problematic issues included the control groups; various hormonal, surgical, cognitive behavioral, and psychotherapeutic treatments; and sample sizes. In the 80 studies compared after the year 2000, 32% were reported after 2000, 45% originated in the United States, 45% were reported in journals, and 36% were unpublished. Treatment characteristics showed a significant lack of pharmacologic treatment (7.5%), whereas use cognitive and classical behavioral therapy was 64%. In 68% of the studies, no information was available on the integrity of the treatment implementation; 36% of the treatment settings were outpatient only, 31% were prison settings, and 12% were mixed settings (prison, hospital, and outpatient). Integrating research interpretations is complicated by the heterogeneity of sex offenders, with only 56% being adult men and 17.5% adolescents. Offense types reported included 74% child molestation, 48% incest, and 30% exhibitionism. Pedophilia was not singled out. Follow-up periods varied from 12 months to greater than 84 months. The definition of recidivism ran the gamut from arrest (24%), conviction (30%), charges (19%), and no indication (16%). Results were difficult to interpret because of the methodological problems with this type of study. Overall, a positive outcome was noted with sex offender treatment. Cognitive-behavioral and hormonal treatment were the most promising. Voluntary treatment led to a slightly better outcome than mandatory participation. When accounting for a low base rate of sexual recidivism, the reduction

  18. Future pharmacological therapy in hypertension. (United States)

    Stewart, Merrill H; Lavie, Carl J; Ventura, Hector O


    Hypertension (HTN) is a widespread and growing disease, with medication intolerance and side-effect present among many. To address these obstacles novel pharmacotherapy is an active area of drug development. This review seeks to explore future drug therapy for HTN in the preclinical and clinical arenas. The future of pharmacological therapy in HTN consists of revisiting old pathways to find new targets and exploring wholly new approaches to provide additional avenues of treatment. In this review, we discuss the current status of the most recent drug therapy in HTN. New developments in well trod areas include novel mineralocorticoid antagonists, aldosterone synthase inhibitors, aminopeptidase-A inhibitors, natriuretic peptide receptor agonists, or the counter-regulatory angiotensin converting enzyme 2/angiotensin (Ang) (1-7)/Mas receptor axis. Neprilysin inhibitors popularized for heart failure may also still hold HTN potential. Finally, we examine unique systems in development never before used in HTN such as Na/H exchange inhibitors, vasoactive intestinal peptide agonists, and dopamine beta hydroxylase inhibitors. A concise review of future directions of HTN pharmacotherapy.

  19. [History and pharmacology of trazodone]. (United States)

    Agnoli, A


    Trazodone, a non-tricyclic molecule, represents the first of a new generation of antidepressants. It is currently marketed in a number of European countries, in the United States and in Latin America. The pharmacological and biochemical data, the mechanism of action and the preferential indications of trazodone are presented and compared to those of imipramine and other tricyclics. Unlike imipramine, trazodone inhibits the adrenergic system. The two molecules have anti-nociceptive properties, similar effects on the serotoninergic system and, after repeated administrations, they both reduce the density of beta-receptors. The clinical implications of the alpha-blocking activity of trazodone are reported. Trazodone is preferable to tricyclic anti-depressants in the treatment of depression in elderly subjects in general, and especially when they present closed angle glaucoma, prostatic hypertrophy, tremor or cardiovascular problems due to hyperactivity of the adrenergic system, as well as in organic depressions and in depression secondary to schizophrenia, alcoholism and in patients with Parkinson's disease.

  20. Cardiovascular Safety Pharmacology of Sibutramine. (United States)

    Yun, Jaesuk; Chung, Eunyong; Choi, Ki Hwan; Cho, Dae Hyun; Song, Yun Jeong; Han, Kyoung Moon; Cha, Hey Jin; Shin, Ji Soon; Seong, Won-Keun; Kim, Young-Hoon; Kim, Hyung Soo


    Sibutramine is an anorectic that has been banned since 2010 due to cardiovascular safety issues. However, counterfeit drugs or slimming products that include sibutramine are still available in the market. It has been reported that illegal sibutramine-contained pharmaceutical products induce cardiovascular crisis. However, the mechanism underlying sibutramine-induced cardiovascular adverse effect has not been fully evaluated yet. In this study, we performed cardiovascular safety pharmacology studies of sibutramine systemically using by hERG channel inhibition, action potential duration, and telemetry assays. Sibutramine inhibited hERG channel current of HEK293 cells with an IC50 of 3.92 μM in patch clamp assay and increased the heart rate and blood pressure (76 Δbpm in heart rate and 51 ΔmmHg in blood pressure) in beagle dogs at a dose of 30 mg/kg (per oral), while it shortened action potential duration (at 10 μM and 30 μM, resulted in 15% and 29% decreases in APD50, and 9% and 17% decreases in APD90, respectively) in the Purkinje fibers of rabbits and had no effects on the QTc interval in beagle dogs. These results suggest that sibutramine has a considerable adverse effect on the cardiovascular system and may contribute to accurate drug safety regulation.

  1. Pharmacological challenges in chronic pancreatitis. (United States)

    Olesen, Anne Estrup; Brokjaer, Anne; Fisher, Iben Wendelboe; Larsen, Isabelle Myriam


    Drug absorption in patients with chronic pancreatitis might be affected by the pathophysiology of the disease. The exocrine pancreatic insufficiency is associated with changes in gastrointestinal intraluminal pH, motility disorder, bacterial overgrowth and changed pancreatic gland secretion. Together these factors can result in malabsorption and may also affect the efficacy of pharmacological intervention. The lifestyle of chronic pancreatitis patients may also contribute to gastrointestinal changes. Many patients limit their food intake because of the pain caused by eating and in some cases food intake is more or less substituted with alcohol, tobacco and coffee. Alcohol and drug interaction are known to influence the pharmacokinetics by altering either drug absorption or by affecting liver metabolism. Since patients suffering from chronic pancreatitis experience severe pain, opioids are often prescribed as pain treatment. Opioids have intrinsic effects on gastrointestinal motility and hence can modify the absorption of other drugs taken at the same time. Furthermore, the increased fluid absorption caused by opioids will decrease water available for drug dissolution and may hereby affect absorption of the drug. As stated above many factors can influence drug absorption and metabolism in patients with chronic pancreatitis. The factors may not have clinical relevance, but may explain inter-individual variations in responses to a given drug, in patients with chronic pancreatitis.

  2. [Pharmacologic treatment of osteoporosis--2011]. (United States)

    Lakatos, Péter


    Osteoporosis affects approximately 9% of the population in Hungary resulting in about 100 000 osteoporotic fractures annually. Thirty-five percent of patients with hip fractures due to osteoporosis will die within 1 year. Direct costs of osteoporosis exceed 25 billion forints per year. Apparently, cost-effective reduction of bone loss and consequent fracture risk will add up to not only financial savings but improvement in quality of life, as well. A number of pharmacological modalities are available for this purpose. The mainstay of the treatment of osteoporosis is the bisphosphonate group that includes effective anti-resorptive compounds mitigating bone loss and fragility. The recently registered denosumab exhibits similar efficacy by neutralizing RANK ligand, however, marked differences can be observed between the two drug classes. Strontium has a unique mechanism of action by rebalancing bone turnover, and thus, providing an efficient treatment option for the not fast bone losers who are at high fracture risk. The purely anabolic teriparatide is available for the extremely severe osteoporotic patients and for those who do not respond to other types of therapy. Older treatment options such as hormone replacement therapy, raloxifene, tibolone or calcitonin may also have a restricted place in the management of osteoporosis.

  3. Pharmacological Fingerprints of Contextual Uncertainty.

    Directory of Open Access Journals (Sweden)

    Louise Marshall


    Full Text Available Successful interaction with the environment requires flexible updating of our beliefs about the world. By estimating the likelihood of future events, it is possible to prepare appropriate actions in advance and execute fast, accurate motor responses. According to theoretical proposals, agents track the variability arising from changing environments by computing various forms of uncertainty. Several neuromodulators have been linked to uncertainty signalling, but comprehensive empirical characterisation of their relative contributions to perceptual belief updating, and to the selection of motor responses, is lacking. Here we assess the roles of noradrenaline, acetylcholine, and dopamine within a single, unified computational framework of uncertainty. Using pharmacological interventions in a sample of 128 healthy human volunteers and a hierarchical Bayesian learning model, we characterise the influences of noradrenergic, cholinergic, and dopaminergic receptor antagonism on individual computations of uncertainty during a probabilistic serial reaction time task. We propose that noradrenaline influences learning of uncertain events arising from unexpected changes in the environment. In contrast, acetylcholine balances attribution of uncertainty to chance fluctuations within an environmental context, defined by a stable set of probabilistic associations, or to gross environmental violations following a contextual switch. Dopamine supports the use of uncertainty representations to engender fast, adaptive responses.

  4. Energy policies of IEA countries: Ireland 2007 review

    Energy Technology Data Exchange (ETDEWEB)



    Ireland's remarkable economic growth over the last 15 years had strong effects on the energy sector. Due to rapidly increasing demand, Ireland has become much more dependent on international energy markets than it was in the past. For Irish energy policy, 2007 marks the end of the transition in market liberalisation with the introduction of a unified national electricity market. In addition, the publication of a new energy policy should help to ensure future security of supply and bring environmental improvements of energy use. Ireland is highly dependent on oil and increasingly dependent on natural gas. The price of these two commodities has strongly increased recently, which results in a heavy burden for the Irish economy and a risk for energy security. The main alternative in the supply side is coal and peat, which causes greenhouse gas emissions to rise much faster than expected. This review analyses the energy challenges facing Ireland and suggests solutions, focussing on moving ahead with market reform and increasing the energy efficiency of the Irish economy. Establishing the 'all-island' electricity market will be of critical importance. Sharper focus on energy efficiency in all sectors of the economy, but in particular in transport and buildings, must be a priority. Finally, to achieve its ambitious goals for renewables in energy supply, Ireland will have to provide ample resources for research and development, to allow technologies such as ocean power to move from the laboratory to the market. 23 figs., 26 tabs., 4 annexes

  5. 9 CFR 93.432 - Cattle from the Republic of Ireland. (United States)


    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Cattle from the Republic of Ireland... Cattle from the Republic of Ireland. (a) All cattle to be imported from the Republic of Ireland shall be... that the cattle originated from a herd which is officially certified by the Republic of Ireland as a...

  6. Medicinal uses, phytochemistry and pharmacology of the genus Uncaria. (United States)

    Zhang, Qian; Zhao, Jiao Jiao; Xu, Jian; Feng, Feng; Qu, Wei


    at C-10 and C-11. Preliminary investigations on pharmacological properties of the Uncaria species have enlightened their efficacious remedy for hypertension, asthma, cancer, diabetes, rheumatism and neurodegenerative diseases. To ensure the safety and effectiveness in clinical application, research on bioactive compounds, pharmacological mechanisms and toxicity of the genus Uncaria as well as the stereo-chemistry and structure-activity relationships of indole alkaloids seem very important. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  7. All Christians? Experiences of science educators in Northern Ireland (United States)

    Murphy, Colette; Hickey, Ivor; Beggs, Jim


    In this paper we respond to Staver's article (this issue) on an attempt to resolve the discord between science and religion. Most specifically, we comment on Staver's downplaying of difference between Catholics and Protestants in order to focus on the religion-science question. It is our experience that to be born into one or other of these traditions in some parts of the world (especially Northern Ireland) resulted in starkly contrasting opportunities, identities and practices in becoming and being science educators. The paper starts with a short contextual background to the impact of religion on schooling and higher education in Northern Ireland. We then explore the lives and careers of three science/religious educators in Northern Ireland: Catholic (Jim) and Protestant (Ivor) males who are contemporaries and whose experience spans pre-Troubles to post-conflict and a Catholic female (Colette) who moved to Northern Ireland during the Troubles as a teenager. Finally, we discuss the situation regarding the teaching of creationism and evolution in Northern Ireland—an issue has recently generated high public interest. The Chair of the Education Committee of the Northern Ireland Assembly recently stated that "creationism is not for the RE class because I believe that it can stand scientific scrutiny and that is a debate which I am quite happy to encourage and be part of…" (News Letter 2008). It could be the case that the evolution debate is being fuelled as a deliberate attempt to undermine some of the post-conflict collaboration projects between schools and communities in Northern Ireland.

  8. Review of the Chemistry and Pharmacology of 7-Methyljugulone ...

    African Journals Online (AJOL)

    Review of the Chemistry and Pharmacology of 7-Methyljugulone. ... Methods: The chemical and pharmacological data were retrieved from the well-known scientific websites such as Pubmed, Google Scholar, Reaxys, Scirus, Scopus, ... Keywords: 7-methyljugulone; biosynthesis; in vitro synthesis; pharmacology

  9. Pharmacology education in North American dental schools: the basic science survey series. (United States)

    Gautam, Medha; Shaw, David H; Pate, Ted D; Lambert, H Wayne


    As part of the Basic Science Survey Series (BSSS) for Dentistry, members of the American Dental Education Association (ADEA) Physiology, Pharmacology, and Therapeutics Section surveyed course directors of basic pharmacology courses in North American dental schools. The survey was designed to assess, among other things, faculty affiliation and experience of course directors, teaching methods, general course content and emphasis, extent of interdisciplinary (shared) instruction, and impact of recent curricular changes. Responses were received from forty-nine of sixty-seven (73.1 percent) U.S. and Canadian dental schools. The findings suggest the following: 1) substantial variation exists in instructional hours, faculty affiliation, placement within curriculum, class size, and interdisciplinary nature of pharmacology courses; 2) pharmacology course content emphasis is similar among schools; 3) the number of contact hours in pharmacology has remained stable over the past three decades; 4) recent curricular changes were often directed towards enhancing the integrative and clinically relevant aspects of pharmacology instruction; and 5) a trend toward innovative content delivery, such as use of computer-assisted instruction applications, is evident. Data, derived from this study, may be useful to pharmacology course directors, curriculum committees, and other dental educators with an interest in integrative and interprofessional education.


    Bondarchuk, N G; Fisenko, V P


    Various stages of scientific research activity of Prof. Vladimir V. Nikolaev are analyzed. The importance of Prof. Nikolaev's discovery of the two-neuron parasympathetic nervous system and some new methods of pharmacological substances evaluation is shown. Prof. Nikolaev is known as the editor of the first USSR Pharmacopoeia. Peculiarities of pharmacology teaching at the First Moscow Medical institute under conditions of changing social demands are described. Successful research of Prof. Nikolaev with colleagues in studying new mechanisms of drug action and developing original pharmacological substances is summarized.

  11. Problems of pharmacological supply of disaster medicine

    International Nuclear Information System (INIS)

    Sabaev, V.V.; Il'ina, S.L.


    The paper reviews a number of pharmacological problems, being important for the disaster medicine, of theoretical and practical nature, the settlement of which would promote more efficient rendering emergency medical aid to the injured persons in the conditions of emergency situations and further expert medical care. On the example of radiation accidents there are studied methodical approaches to organization of drug prophylaxis and therapy of the injured persons in emergency situations. The authors have proved the necessity of arranging proper pharmacological supply of disaster medicine which is to settle the whole complex of scientific-applied and organizational questions relating to the competence of pharmacology and pharmacy. 17 refs

  12. [Contribution of animal experimentation to pharmacology]. (United States)

    Sassard, Jean; Hamon, Michel; Galibert, Francis


    Animal experimentation is of considerable importance in pharmacology and cannot yet be avoided when studying complex, highly integrated physiological functions. The use of animals has been drastically reduced in the classical phases of pharmacological research, for example when comparing several compounds belonging to the same pharmacological class. However, animal experiments remain crucial for generating and validating new therapeutic concepts. Three examples of such research, conducted in strict ethical conditions, will be used to illustrate the different ways in which animal experimentation has contributed to human therapeutics.

  13. Invasive meningococcal disease in children in Ireland, 2001-2011.

    LENUS (Irish Health Repository)

    Ó Maoldomhnaigh, Cilian


    In 1999, invasive meningococcal disease was hyperendemic in Ireland at 14.75\\/100 000 population, with 60% group B and 30% group C diseases. National sepsis guidelines and meningococcal C vaccines were introduced in 2000. Despite a spontaneous decline in group B infection, invasive meningococcal disease remains a leading cause of sepsis. This study characterises the epidemiology of invasive meningococcal disease in children in Ireland since the introduction of meningococcal C vaccine and reviews its clinical presentation, hospital course and outcome in anticipation of meningococcal B vaccine introduction.

  14. Lucas and patriotism in mid-eighteenth century Ireland. (United States)

    Magennis, E


    This paper explores the extent to which Charles Lucas can be described as a typical patriot in mid-eighteenth century Ireland. The political ideas and practices of Irish patriots of the mid-eighteenth century belong to broad spectrum including opposition MPs, anti-Catholic rhetoricians and questioners of the usefulness of the penal laws, economic pamphleteers and individuals interested in recovering Ireland's history and antiquities. Lucas was significant in that he sometimes inhabited all of these political and cultural guises, but also mobilised the Dublin public in political campaigns and was striking in his voluminous output in newspapers and pamphlets.

  15. Female role models in physics education in Ireland (United States)

    Chormaic, Síle Nic; Fee, Sandra; Tobin, Laura; Hennessy, Tara


    In this paper we consider the statistics on undergraduate student representation in Irish universities and look at student numbers in secondary (high) schools in one region in Ireland. There seems to be no significant change in female participation in physics from 2002 to 2011. Additionally, we have studied the influence of an educator's gender on the prevalence of girls studying physics in secondary schools in Co. Louth, Ireland, and at the postgraduate level in Irish universities. It would appear that strong female role models have a positive influence and lead to an increase in girls' participation in physics.

  16. Phytochemical and pharmacological overview on Liriopes radix

    African Journals Online (AJOL)

    Department of Pharmacology and Toxicology, Metabolic Diseases Research Laboratory, School of Dentistry, Kyung Hee. University ... has been used as a therapeutic drug for the treatment of ..... Alzheimer's disease (AD) is characterized by.

  17. Ethnobotanical, phytochemical and pharmacological properties of ...

    African Journals Online (AJOL)

    Electronic search engines such as Google, Google scholar, publishing sites such as Elsevier .... A number of pharmacological activities of C. bulbispermum have been ..... bulbispermum using the direct plate method and minimum inhibitory ...

  18. Bioanalysis, metabolism & clinical pharmacology of antiretroviral drugs

    NARCIS (Netherlands)

    Heine, R. ter


    The aims of all studies described in this thesis were to develop new bioanalytical and more patient friendly methods for studying the clinical pharmacology of antiretroviral drugs and to ultimately improve antiretroviral treatment.

  19. Medicinal, Pharmacological and Phytochemical Potentials of ...

    African Journals Online (AJOL)

    Medicinal, Pharmacological and Phytochemical Potentials of Annona Comosus linn. ... Therapeutic plants, and the drugs derived from them, are the most important ... also as treatment to: diarrhea, indigestion, pneumonia, bronchitis, arthritis, ...

  20. Disrupting reconsolidation: pharmacological and behavioral manipulations

    NARCIS (Netherlands)

    Soeter, M.; Kindt, M.


    We previously demonstrated that disrupting reconsolidation by pharmacological manipulations "deleted" the emotional expression of a fear memory in humans. If we are to target reconsolidation in patients with anxiety disorders, the disruption of reconsolidation should produce content-limited

  1. Pharmaceutical and pharmacological approaches for bioavailability

    Indian Academy of Sciences (India)


    Jan 27, 2014 ... Etoposide posses high plasma protein binding (97%) and is degraded via ... The present article gives insight on pharmaceutical and pharmacological .... caprolactone and were found efficient as drug delivery vehicles.

  2. ORIGINAL ARTICLES Pharmacological testing in Horner's syndrome

    African Journals Online (AJOL)

    topical cocaine 10% in both eyes gave an odds ratio of 1 050:1 that. Horner's syndrome ... nerve endings and therefore do not stimulate the effector cells directly. ... Pharmacological testing in Horner's syndrome – a new paradigm. Derrick P ...

  3. [Adherence to pharmacological treatment in adult patients undergoing hemodialysis]. (United States)

    Sgnaolin, Vanessa; Figueiredo, Ana Elizabeth Prado Lima


    Adherence to treatment in patients on hemodialysis is not a simple process. Strategies to promote adherence will meet the need for improvements in the process of orientation concerning the disease and its pharmacological treatment. To identify compliance with pharmacological treatment of patients on hemodialysis and the main factors related to it we used the Adherence Scale. Observational, descriptive and cross-sectional study. Interviews were conducted to collect socioeconomic, pharmacological data, as well as those regarding self-reported adherence to drug. Out of the 65 participants, 55.4% showed non-compliance. The mean number of drugs used was 4.1 ± 2.5 (self-report) and 6.2 ± 3.0 (prescription). Statistical analysis showed significant differences concerning compliance at different ages (> 60 years are more adherent). A significant proportion of patients have difficulty to comply with treatment and the main factor was forgetfulness. Regarding age, elderly patients are more adherent to treatment. The low level of knowledge about the used drugs may be one of the reasons for the lack of adherence, and the patient's orientation process by a team of multiprofessionals involved in assisting is a strategy to promote adherence.

  4. Precision pharmacology for Alzheimer's disease. (United States)

    Hampel, Harald; Vergallo, Andrea; Aguilar, Lisi Flores; Benda, Norbert; Broich, Karl; Cuello, A Claudio; Cummings, Jeffrey; Dubois, Bruno; Federoff, Howard J; Fiandaca, Massimo; Genthon, Remy; Haberkamp, Marion; Karran, Eric; Mapstone, Mark; Perry, George; Schneider, Lon S; Welikovitch, Lindsay A; Woodcock, Janet; Baldacci, Filippo; Lista, Simone


    The complex multifactorial nature of polygenic Alzheimer's disease (AD) presents significant challenges for drug development. AD pathophysiology is progressing in a non-linear dynamic fashion across multiple systems levels - from molecules to organ systems - and through adaptation, to compensation, and decompensation to systems failure. Adaptation and compensation maintain homeostasis: a dynamic equilibrium resulting from the dynamic non-linear interaction between genome, epigenome, and environment. An individual vulnerability to stressors exists on the basis of individual triggers, drivers, and thresholds accounting for the initiation and failure of adaptive and compensatory responses. Consequently, the distinct pattern of AD pathophysiology in space and time must be investigated on the basis of the individual biological makeup. This requires the implementation of systems biology and neurophysiology to facilitate Precision Medicine (PM) and Precision Pharmacology (PP). The regulation of several processes at multiple levels of complexity from gene expression to cellular cycle to tissue repair and system-wide network activation has different time delays (temporal scale) according to the affected systems (spatial scale). The initial failure might originate and occur at every level potentially affecting the whole dynamic interrelated systems within an organism. Unraveling the spatial and temporal dynamics of non-linear pathophysiological mechanisms across the continuum of hierarchical self-organized systems levels and from systems homeostasis to systems failure is key to understand AD. Measuring and, possibly, controlling space- and time-scaled adaptive and compensatory responses occurring during AD will represent a crucial step to achieve the capacity to substantially modify the disease course and progression at the best suitable timepoints, thus counteracting disrupting critical pathophysiological inputs. This approach will provide the conceptual basis for effective

  5. Punishment, Pharmacological Treatment, and Early Release

    DEFF Research Database (Denmark)

    Ryberg, Jesper


    Recent studies have shown that pharmacological treatment may have an impact on aggressive and impulsive behavior. Assuming that these results are correct, would it be morally acceptable to instigate violent criminals to accept pharmacological rehabilitation by offering this treatment in return fo...... relates to the acceptability of the fact that those criminals who accepted the treatment would be exempted from the punishment they rightly deserved. It is argued that none of these reasons succeeds in rejecting this sort of offer....

  6. Radon Gas in Ireland Joint Position Statement by the Radiological Protection Institute of Ireland and the Health Service Executive

    International Nuclear Information System (INIS)

    Part, A.M.; Colgan, P.A.; Fenton, D.; Kelly, I.; Long, S.; O'Mahony, M.; Pollard, D.


    This position statement is written by the Health Service Executive and the Radiological Protection Institute of Ireland with a view to forming and influencing policy in this area. It provides a summary of the health risks associated with radon exposure in Ireland and the steps that can be taken to reduce those risks. It outlines suggested ongoing work to reduce both the population dose from radon and the individual dose to those most at risk and considers future work needed to improve national policy to achieve these objectives

  7. A comparison of medical and pharmacy students' knowledge and skills of pharmacology and pharmacotherapy. (United States)

    Keijsers, Carolina J P W; Brouwers, Jacobus R B J; de Wildt, Dick J; Custers, Eugene J F M; Ten Cate, Olle Th J; Hazen, Ankie C M; Jansen, Paul A F


    Pharmacotherapy might be improved if future pharmacists and physicians receive a joint educational programme in pharmacology and pharmacotherapeutics. This study investigated whether there are differences in the pharmacology and pharmacotherapy knowledge and skills of pharmacy and medical students after their undergraduate training. Differences could serve as a starting point from which to develop joint interdisciplinary educational programmes for better prescribing. In a cross-sectional design, the knowledge and skills of advanced pharmacy and medical students were assessed, using a standardized test with three domains (basic pharmacology knowledge, clinical or applied pharmacology knowledge and pharmacotherapy skills) and eight subdomains (pharmacodynamics, pharmacokinetics, interactions and side-effects, Anatomical Therapeutic Chemical Classification groups, prescribing, prescribing for special groups, drug information, regulations and laws, prescription writing). Four hundred and fifty-one medical and 151 pharmacy students were included between August 2010 and July 2012. The response rate was 81%. Pharmacy students had better knowledge of basic pharmacology than medical students (77.0% vs. 68.2% correct answers; P students had better skills than pharmacy students in writing prescriptions (68.6% vs. 50.7%; P students had similar knowledge of applied pharmacology (73.8% vs. 72.2%, P = 0.124, δ = 0.15). Pharmacy students have better knowledge of basic pharmacology, but not of the application of pharmacology knowledge, than medical students, whereas medical students are better at writing prescriptions. Professional differences in knowledge and skills therefore might well stem from their undergraduate education. Knowledge of these differences could be harnessed to develop a joint interdisciplinary education for both students and professionals. © 2014 The British Pharmacological Society.

  8. Women and the Struggle for Daytime Adult Education in Ireland. (United States)

    Inglis, Tom


    Daytime adult education has emerged in Ireland in the form of voluntary, locally based groups of working class women providing education for themselves and others. A survey of 96 groups illuminated their struggles with finding suitable space, day care, and advertising. They thrive because of disenchantment with the content, scheduling, and form of…

  9. Decomposing socioeconomic inequality in child vaccination: results from Ireland. (United States)

    Doherty, Edel; Walsh, Brendan; O'Neill, Ciaran


    There is limited knowledge of the extent of or factors underlying inequalities in uptake of childhood vaccination in Ireland. This paper aims to measure and decompose socioeconomic inequalities in childhood vaccination in the Republic of Ireland. The analysis was performed using data from the first wave of the Growing Up in Ireland survey, a nationally representative survey of the carers of over 11,000 nine-month old babies collected in 2008 and 2009. Multivariate analysis was conducted to explore the child and parental factors, including socioeconomic factors that were associated with non-vaccination of children. A concentration index was calculated to measure inequality in childhood vaccination. Subsequent decomposition analysis identified key factors underpinning observed inequalities. Overall the results confirm a strong socioeconomic gradient in childhood vaccination in the Republic of Ireland. Concentration indices of vaccination (CI=-0.19) show a substantial pro-rich gradient. Results from the decomposition analysis suggest that a substantial proportion of the inequality is explained by household level variables such as socioeconomic status, household structure, income and entitlement to publicly funded care (29.9%, 24% 30.6% and 12.9% respectively). Substantial differences are also observed between children of Irish mothers and immigrant mothers from developing countries. Vaccination was less likely in lower than in higher income households. Access to publicly funded services was an important factor in explaining inequalities. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. The customized fetal growth potential: a standard for Ireland.

    LENUS (Irish Health Repository)

    Unterscheider, Julia


    To identify maternal and pregnancy-related physiological and pathological variables associated with fetal growth and birthweight in Ireland and to develop customized birthweight centile charts for the Irish population that will aid in appropriate identification and selection of growth-restricted fetuses requiring increased antenatal surveillance.

  11. It's Not an Exact Science: Teaching Entrepreneurship in Northern Ireland (United States)

    Hegarty, Cecilia


    Purpose: The purpose of this paper is to evaluate the approach to embedding entrepreneurship within third level education in Northern Ireland by assessing the perceptions of lecturers and learners and monitoring the effectiveness of teaching methods. Design/methodology/approach: Surveys and focus groups were conducted with lecturers and learners…

  12. Ireland's pathway towards a 100% renewable energy-system

    DEFF Research Database (Denmark)

    Connolly, David; Leahy, Martin; Lund, Henrik


    Ireland has an abundant supply of renewable energy, a dangerous reliance on imported fossil fuels, as well as very demanding energy and CO2 targets to reach. All of these indicate that a major alternation to the current energy system is necessary, especially an increase in the utilisation of rene...

  13. Just a Phase? Youth Unemployment in the Republic of Ireland (United States)

    Smyth, Emer


    Ireland has experienced an unprecedented level of economic growth since the mid-1990s. The present article assesses the extent to which this phenomenon has altered the level and nature of youth unemployment, using data from six waves of a nationally representative survey of school-leavers. The main impact of the "Celtic Tiger" has been…

  14. Survey of diagnostic radiology in the Republic of Ireland

    International Nuclear Information System (INIS)

    Cunningham, J.D.; Howett, D.; Hone, C.; Mulholland, C.


    This survey examined a number of aspects of the practice of diagnostic radiology in Ireland. These included the frequency of examinations, the gonadal and active bone marrow doses to patients, the genetically significant dose, the standard of design of x-ray rooms and of performance of equipment, and an inventory of equipment currently in use (author)

  15. How Do Teachers in Ireland and England Conceptualise Dyslexia? (United States)

    Bell, Sheena; McPhillips, Therese; Doveston, Mary


    This paper presents the findings of a comparative study using data from questionnaire surveys carried out in England (n = 57) and Ireland (n = 72). The researchers examine how teachers and teaching assistants who are currently teaching pupils with dyslexia in primary schools describe dyslexia and what may have influenced their conceptualisation.…

  16. Hearing Voices: Lessons from the History of Psychiatry in Ireland. (United States)

    Kelly, B D


    The history of psychiatry is a history of therapeutic enthusiasm, with all of the triumph and tragedy, hubris and humility that such enthusiasm brings. During the 1800s and early 1900s, Ireland-s public asylums were routinely overcrowded, unhygienic and, quite commonly, fatal. The asylums became all-too-convenient options for a society with an apparently insatiable hunger for institutions, incarceration and control. The emergence of clinical professionals, both medical and nursing, was inevitably a factor in this complex mix, but the effects of any search for professional prestige were dwarfed by asylum doctors' clear outrage at what the asylum system became. There were powerful, non-medical, vested interests in keeping large asylums open. Irish society consistently failed to generate solutions to real human suffering (mental illness, disability, disease, poverty, ill fortune) other than the extraordinary network of institutions that characterised so much of Irish history: orphanages, industrial schools, reformatories, workhouses, laundries, borstals, prisons and asylums. As a result, Ireland's remarkable asylum system was primarily a social creation rather than a medical one. Notwithstanding this complex history, Ireland's mental health services have been transformed over the past five decades, although real challenges remain, especially in relation to the homeless mentally ill, the mentally ill in prison, and providing meaningful support to families.

  17. A Strategy for the Digital Content Industry in Ireland



    There is a real opportunity for Ireland to develop a significant strength in the digital content industries of the future and to develop strong digital content clusters of high-growth, high-value digital businesses. This report identifies five key target areas: e-Learning, Games, Business and Consumer Wireless Services, Digital Libraries, and Non-Media Digital Applications

  18. Reviving a Community, Modernizing an Industry: Ireland's Furniture College. (United States)

    Regional Technology Strategies, Inc., Carrboro, NC.

    Connemara, a rural region in Ireland, is characterized by high unemployment, high emigration, poor infrastructure, inadequate public services, and a low rate of transfer to third-level education. To address the situation, the Galway-Mayo Institute of Technology (GMIT), joined forces with Connemara West (a community-owned development organization…

  19. Religious Education and the Law in Northern Ireland's Controlled Schools (United States)

    Armstrong, David


    This article examines the legislation under which religious education operates in Northern Ireland's schools. A brief historical sketch identifies the Irish Churches' interest in the educational debates of the 1920s and 1930s. The legislation that established religious education in the curriculum is traced from those debates to the present…

  20. Trends in air pollution in Ireland : A decomposition analysis

    NARCIS (Netherlands)

    Tol, Richard S.J.


    Trends in the emissions to air of sulphur dioxide, nitrogen oxides, carbon monoxide, volatile organic compounds and ammonia in Ireland are analysed with a logarithmic mean Divisia index decomposition for the period of 1990-2009. Emissions fell for four of the five pollutants, with ammonia being

  1. Nontuberculous mycobacteria: incidence in Southwest Ireland from 1987 to 2000.

    LENUS (Irish Health Repository)

    Kennedy, M P


    SETTING: The Southwest of Ireland (Counties Cork and Kerry) 1987-2000, average population 549,500. OBJECTIVE: Nontuberculous mycobacteria (NTM) cause significant morbidity worldwide and the study of epidemiology and characteristics helps in their prevention and treatment. This study was performed to determine the incidence of NTM disease in comparison to Mycobacterium tuberculosis (M. tuberculosis) and Mycobacterium bovis (M. bovis) in Southwest Ireland, over the above time period. DESIGN: A retrospective study was carried out in all human isolates of NTM, M. tuberculosis and M. bovis between 1987 and 2000, in the Southwest Region of Ireland. RESULTS: The mean incidence of NTM (0.4\\/100,000 population) has risen since 1995, principally of pulmonary Mycobacterium avium intracellulare complex (MAC). The annual incidence of M. tuberculosis in humans over 14 years in the same region was 971\\/100,000 population with a significant reduction since 1994 and M. bovis remained constant at 0.5\\/100,000 population. CONCLUSION: The increasing incidence of disease causing NTM noted in Southwest Ireland reflects global data and is surmised to be due to an ageing population, increased incidence related to chronic fibrotic lung disease, and environmental mycobacterial factors.

  2. The Changing Family in Northern Ireland: Young People and Divorce. (United States)

    Fawcett, Margaret I.


    Interviewed adolescents in Northern Ireland to investigate their experiences with the divorce process and help provided by family, friends, and professionals. They considered the separation/divorce process long, frequently underpinned by acrimony and violence. Extended family and peers provided great support. Many teens used specialist counselors…

  3. Relationships of People with Learning Disabilities in Ireland (United States)

    Bane, Geraldine; Deely, Marie; Donohoe, Brian; Dooher, Martin; Flaherty, Josephine; Iriarte, Edurne Garcia; Hopkins, Rob; Mahon, Ann; Minogue, Ger; Mc Donagh, Padraig; O'Doherty, Siobhain; Curry, Martin; Shannon, Stephen; Tierney, Edel; Wolfe, Marie


    This study explored the perspectives of people with learning disabilities on relationships and supports in the Republic of Ireland. A national research network consisting of 21 researchers with learning disabilities, 12 supporters, and 7 university researchers conducted the study. Researchers with learning disabilities and their supporters ran 16…

  4. Logistic regression model for detecting radon prone areas in Ireland. (United States)

    Elío, J; Crowley, Q; Scanlon, R; Hodgson, J; Long, S


    A new high spatial resolution radon risk map of Ireland has been developed, based on a combination of indoor radon measurements (n=31,910) and relevant geological information (i.e. Bedrock Geology, Quaternary Geology, soil permeability and aquifer type). Logistic regression was used to predict the probability of having an indoor radon concentration above the national reference level of 200Bqm -3 in Ireland. The four geological datasets evaluated were found to be statistically significant, and, based on combinations of these four variables, the predicted probabilities ranged from 0.57% to 75.5%. Results show that the Republic of Ireland may be divided in three main radon risk categories: High (HR), Medium (MR) and Low (LR). The probability of having an indoor radon concentration above 200Bqm -3 in each area was found to be 19%, 8% and 3%; respectively. In the Republic of Ireland, the population affected by radon concentrations above 200Bqm -3 is estimated at ca. 460k (about 10% of the total population). Of these, 57% (265k), 35% (160k) and 8% (35k) are in High, Medium and Low Risk Areas, respectively. Our results provide a high spatial resolution utility which permit customised radon-awareness information to be targeted at specific geographic areas. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Pharmacological interventions for acute pancreatitis. (United States)

    Moggia, Elisabetta; Koti, Rahul; Belgaumkar, Ajay P; Fazio, Federico; Pereira, Stephen P; Davidson, Brian R; Gurusamy, Kurinchi Selvan


    In people with acute pancreatitis, it is unclear what the role should be for medical treatment as an addition to supportive care such as fluid and electrolyte balance and organ support in people with organ failure. To assess the effects of different pharmacological interventions in people with acute pancreatitis. We searched the Cochrane Central Register of Controlled Trials (CENTRAL, 2016, Issue 9), MEDLINE, Embase, Science Citation Index Expanded, and trial registers to October 2016 to identify randomised controlled trials (RCTs). We also searched the references of included trials to identify further trials. We considered only RCTs performed in people with acute pancreatitis, irrespective of aetiology, severity, presence of infection, language, blinding, or publication status for inclusion in the review. Two review authors independently identified trials and extracted data. We did not perform a network meta-analysis as planned because of the lack of information on potential effect modifiers and differences of type of participants included in the different comparisons, when information was available. We calculated the odds ratio (OR) with 95% confidence intervals (CIs) for the binary outcomes and rate ratios with 95% CIs for count outcomes using a fixed-effect model and random-effects model. We included 84 RCTs with 8234 participants in this review. Six trials (N = 658) did not report any of the outcomes of interest for this review. The remaining 78 trials excluded 210 participants after randomisation. Thus, a total of 7366 participants in 78 trials contributed to one or more outcomes for this review. The treatments assessed in these 78 trials included antibiotics, antioxidants, aprotinin, atropine, calcitonin, cimetidine, EDTA (ethylenediaminetetraacetic acid), gabexate, glucagon, iniprol, lexipafant, NSAIDs (non-steroidal anti-inflammatory drugs), octreotide, oxyphenonium, probiotics, activated protein C, somatostatin, somatostatin plus omeprazole, somatostatin

  6. Pharmacological potential and conservation prospect of the genus Eucomis (Hyacinthaceae) endemic to southern Africa. (United States)

    Masondo, Nqobile A; Finnie, Jeffrey F; Van Staden, Johannes


    The genus Eucomis (Hyacinthaceae) consists of 10 species that are extensively used in African traditional medicine. This review is an appraisal of current information on the distribution and morphology, traditional uses, pharmacology, toxicology and approaches devised to enhance the conservation of the genus. A systematic and comprehensive literature search using electronic searches such as Scopus, Google Scholar, Web of Science and ethnobotanical books was conducted. Evidence from traditional medicine usage shows wide utilization of this genus for ailments such as respiratory, venereal diseases, rheumatism as well as kidney and bladder infections. Pharmacological screening reported antimicrobial, antiplasmodial, antitumor, cytotoxic, phytotoxic and anti-inflammatory properties. The potential of the genus Eucomis especially in terms of pharmacology cannot be overemphasized. Apart from the anti-inflammatory properties, the antifungal activity of Eucomis remains a valuable reservoir with potential application in the agriculture sector as a source of an affordable biocontrol agent. Based on the speculated toxic constituents in the genus Eucomis, it will be valuable to conduct detailed toxicological studies. Extensive utilization of members of the genus Eucomis is causing severe strain on wild populations. Although conventional propagation has been relatively effective in the alleviation of the declining status, micropropagation of members may be vital to guarantee the conservation of wild populations. © 2013 Elsevier Ireland Ltd. All rights reserved.

  7. Illicium verum: a review on its botany, traditional use, chemistry and pharmacology. (United States)

    Wang, Guo-Wei; Hu, Wen-Ting; Huang, Bao-Kang; Qin, Lu-Ping


    The fruit of Illicium verum Hook. f. (Chinese star anise) has long been used in traditional Chinese medicine and food industry with the actions of dispelling cold, regulating the flow of Qi and relieving pain. A bibliographic investigation was carried out by analyzing recognized books including Chinese herbal classic, and worldwide accepted scientific databases (Pubmed, SciFinder, Scopus and Web of Science) were searched for the available information on I. verum. I. verum is an aromatic evergreen tree of the family Illiciaceae. It is sometimes contaminated with highly toxic Japanese star anise (I. anisatum L.) and poisonous star anise (I. lanceolatum A. C. Smith), which contain several neurotoxic sesquiterpenes. Traditional uses of I. verum are recorded throughout Asia and Northern America, where it has been used for more than 10 types of disorders. Numerous compounds including volatiles, seco-prezizaane-type sesquiterpenes, phenylpropanoids, lignans, flavonoids and other constituents have been identified from I. verum. Modern pharmacology studies demonstrated that its crude extracts and active compounds possess wide pharmacological actions, especially in antimicrobial, antioxidant, insecticidal, analgesic, sedative and convulsive activities. In addition, it is the major source of shikimic acid, a primary ingredient in the antiflu drug (Tamiflu). This review summarizes the up-to-date and comprehensive information concerning the botany, traditional use, phytochemistry and pharmacology of I. verum together with the toxicology, and discusses the possible trend and scope for future research of I. verum. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  8. Parental knowledge, attitudes and beliefs on fever: a cross-sectional study in Ireland.

    LENUS (Irish Health Repository)

    Kelly, Maria


    Fever is a common symptom of mostly benign illness in young children, yet concerning for parents. The aim of this study was to describe parental knowledge, attitudes and beliefs regarding fever in children aged ≤5 years of age.

  9. Hazardous alcohol consumption among university students in Ireland: a cross-sectional study.

    LENUS (Irish Health Repository)

    Davoren, Martin P


    There is considerable evidence of a cultural shift towards heavier alcohol consumption among university students, especially women. The aim of this study is to investigate the prevalence and correlates of hazardous alcohol consumption (HAC) among university students with particular reference to gender and to compare different modes of data collection in this population.

  10. Pharmacological stress agents in nuclear cardiology

    International Nuclear Information System (INIS)

    Buscombe, J.R.


    Treadmill test combined with myocardial perfusion scintigraphy (MPS) is a commonly used technique in the assessment of coronary artery disease. However there are a group of patients who may not be able to undergo treadmill tests. Patients with underlying conditions like neuromuscular disease, musculoskeletal disorder, heart failure and end-stage renal disease (ESRD) on renal dialysis would find it difficult to perform exercise on a treadmill or bicycle ergometer. These conditions prevent them from performing adequate exercise. Such patients would benefit from pharmacological stress procedures combined with MPS. Nuclear medicine departments use various pharmacological agents while performing stress tests on cardiac patients. The most commonly used pharmacological agents for cardiac stress are coronary vasodilators and catecholamines. In addition to these agents, adjuvant use of nitrates and atropine is also a common practice in nuclear cardiology. This review addresses various physiological and pharmacological properties of the commonly used pharmacological stress agents in MPS and critically analyses their advantages and disadvantages, as well as their safety and efficacy. (author)

  11. Non Pharmacological Cognitive Enhancers - Current Perspectives. (United States)

    Sachdeva, Ankur; Kumar, Kuldip; Anand, Kuljeet Singh


    Cognition refers to the mental processes involved in thinking, knowing, remembering, judging, and problem solving. Cognitive dysfunctions are an integral part of neuropsychiatric disorders as well as in healthy ageing. Cognitive Enhancers are molecules that help improve aspects of cognition like memory, intelligence, motivation, attention and concentration. Recently, Non Pharmacological Cognitive Enhancers have gained popularity as effective and safe alternative to various established drugs. Many of these Non Pharmacological Cognitive Enhancers seem to be more efficacious compared to currently available Pharmacological Cognitive Enhancers. This review describes and summarizes evidence on various Non Pharmacological Cognitive Enhancers such as physical exercise, sleep, meditation and yoga, spirituality, nutrients, computer training, brain stimulation, and music. We also discuss their role in ageing and different neuro-psychiatric disorders, and current status of Cochrane database recommendations. We searched the Pubmed database for the articles and reviews having the terms 'non pharmacological and cognitive' in the title, published from 2000 till 2014. A total of 11 results displayed, out of which 10 were relevant to the review. These were selected and reviewed. Appropriate cross-references within the articles along with Cochrane reviews were also considered and studied.

  12. Pharmacological screening technologies for venom peptide discovery. (United States)

    Prashanth, Jutty Rajan; Hasaballah, Nojod; Vetter, Irina


    Venomous animals occupy one of the most successful evolutionary niches and occur on nearly every continent. They deliver venoms via biting and stinging apparatuses with the aim to rapidly incapacitate prey and deter predators. This has led to the evolution of venom components that act at a number of biological targets - including ion channels, G-protein coupled receptors, transporters and enzymes - with exquisite selectivity and potency, making venom-derived components attractive pharmacological tool compounds and drug leads. In recent years, plate-based pharmacological screening approaches have been introduced to accelerate venom-derived drug discovery. A range of assays are amenable to this purpose, including high-throughput electrophysiology, fluorescence-based functional and binding assays. However, despite these technological advances, the traditional activity-guided fractionation approach is time-consuming and resource-intensive. The combination of screening techniques suitable for miniaturization with sequence-based discovery approaches - supported by advanced proteomics, mass spectrometry, chromatography as well as synthesis and expression techniques - promises to further improve venom peptide discovery. Here, we discuss practical aspects of establishing a pipeline for venom peptide drug discovery with a particular emphasis on pharmacology and pharmacological screening approaches. This article is part of the Special Issue entitled 'Venom-derived Peptides as Pharmacological Tools.' Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Only connect: the merger of BMC Pharmacology and BMC Clinical Pharmacology. (United States)

    Moylan, Elizabeth C; Morrey, Christopher; Appleford-Cook, Joanne M


    This editorial celebrates the launch of BMC Pharmacology and Toxicology within the BMC series of journals published by BioMed Central. The scope of the journal is interdisciplinary encompassing toxicology, experimental and clinical pharmacology including clinical trials. In this editorial we discuss the origins of this new journal and the ethos and policies under which it will operate.

  14. Smoking prevalence among qualified nurses in the Republic of Ireland and their role in smoking cessation. (United States)

    O'Donovan, Geraldine


    Smoking is the leading preventable cause of premature mortality, killing approximately 6000 people in Ireland each year. On 29 March 2004, the Republic of Ireland became the first country in the world to ban smoking in all workplaces, including bars and restaurants. This study took place after the introduction of this smoking ban. An admission to hospital provides an opportunity to help people stop smoking. Nurses' role and wide availability puts them in a prime position to encourage people to quit smoking. To examine the smoking prevalence among qualified nurses at a large university teaching hospital in Cork Southern Ireland and their role in smoking cessation. This was a descriptive cross-sectional study using a calculated sample of 430 qualified nurses (with a 70% response rate). A structured questionnaire was used. It was found that 21% (n = 63) of nurses were smokers, 23% (n = 70) were ex-smokers and 56% (n = 167) were non-smokers. The highest prevalence of smokers was found in the age groups 20-25 years (28%, n = 17) and 26-30 years (34%, n = 21). Nurses working within psychiatric care (47.4%) and coronary care (33.3%) had the highest smoking prevalence among the nurses who smoked. The study found that there was a significant difference between the attitudes of smokers and non-smokers, 89% (n = 211) of non-smokers strongly agreed that cigarette smoke represents a major risk to health in comparison with only 65% (n = 41) of smokers. Only 14% (n = 43) of the nurses surveyed had received training in smoking cessation. Lack of time (74%) and lack of training (65%) were the two main reasons given by nurses for not giving smoking cessation advice to patients. Nurses' potential in preventive health care has been largely under-utilized. Lack of time and training are major factors inhibiting nurses' role in smoking cessation with their patients.

  15. Examining the breastfeeding support resources of the public health nursing services in Ireland. (United States)

    Mulcahy, Helen; Phelan, Agnes; Corcoran, Paul; Leahy-Warren, Patricia


    The aim of the study was to review breastfeeding support provided by Public Health Nurses in Ireland. The objectives were to identify the availability of appropriate guiding policies, educational preparation, attitude of Public Health Nurses and the availability and use of other supportive services. Breastfeeding rates in Ireland are among the lowest in Europe. The main source of formal support for breastfeeding mothers in the community in Ireland is from Public Health Nurses who can make referral to other non-statutory resources. The nature of this support is determined by policies guiding clinical practice and education that increases breastfeeding confidence and competence of all personnel. Consequently, an assessment of breastfeeding resources requires an analysis of all these variables. A large quantitative, cross-sectional study was conducted, involving Public Health Nurses and mothers. This paper represents the results from the perspective of Public Health Nurses. Directors of Public Health Nursing (n = 24) and Public Health Nurses (n = 204) completed self-report questionnaires by mail and online. Data were analysed using the Statistical Package for Social Sciences and reported using descriptive and inferential statistics. Public Health Nurses are well educated to support breastfeeding and have a positive attitude and a high degree of self-assessed confidence and competence. A wide variety of non-statutory support exists for breastfeeding but is not always used to their full potential. Standardising educational requirements for Public Health Nurses in supporting breastfeeding is an area that requires attention. Ultimately, service delivery in relation to supporting breastfeeding mothers would benefit from being more timely and responsive. Awareness of support resources is necessary for Public Health Nurses to make appropriate referrals for breastfeeding mothers. Furthermore, Directors of Public Health Nursing need to encourage the breastfeeding supportive

  16. 3,4-methylenedioxypyrovalerone (MDPV): chemistry, pharmacology and toxicology of a new designer drug of abuse marketed online. (United States)

    Coppola, M; Mondola, R


    The illicit marketplace of substances of abuse continually offers for sale legal alternatives to controlled drugs to a large public. In recent years, a new group of designer drugs, the synthetic cathinones, has emerged as a new trend, particularly among young people. The 3,4-methylenedioxypyrovalerone (MDPV), one of this synthetic compounds, caused an international alert for its cardiovascular and neurological toxicity. This substance, sold as bath salts, has caused many serious intoxications and some deaths in several countries. The aim of this paper is summarise the clinical, pharmacological and toxicological information about this new designer drug. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  17. Perinatal pharmacology: applications for neonatal neurology. (United States)

    Smits, Anne; Allegaert, Karel


    The principles of clinical pharmacology also apply to neonates, but their characteristics warrant a tailored approach. We focus on aspects of both developmental pharmacokinetics (concentration/time relationship) and developmental pharmacodynamics (concentration/effect relationship) in neonates. We hereby aimed to link concepts used in clinical pharmacology with compound-specific observations (anti-epileptics, analgosedatives) in the field of neonatal neurology. Although in part anecdotal, we subsequently illustrate the relevance of developmental pharmacology in the field of neonatal neurology by a specific intervention (e.g. whole body cooling), specific clinical presentations (e.g. short and long term outcome following fetal exposure to antidepressive agents, the development of new biomarkers for fetal alcohol syndrome) and specific clinical needs (e.g. analgosedation in neonates, excitocytosis versus neuro-apoptosis/impaired synaptogenesis). Copyright © 2011 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

  18. Personal and professional challenges of nurse prescribing in Ireland. (United States)

    McBrien, Barry

    This article presents the challenges regarding the development of a collaborative practice agreement in order to undertake nurse prescribing in an emergency department in a large teaching hospital. Nurse prescribing has been introduced quite recently in Ireland. Although there is a plethora of knowledge regarding the topic, there are many personal and professional challenges in relation to this emerging role. The nurse prescribing initiative in Ireland is continually developing and many nurses now have the authority to prescribe from almost the same range of medicines as doctors. Prescribing has the potential to improve job satisfaction, autonomy and ultimately improves patient outcomes. However, nurses need to be cognisant of the impact it can have on the dynamics of the healthcare team. An analysis of some complexities of nurse prescribing is given, in conjunction with reflective thoughts on a clinical incident in the area of morphine prescribing.

  19. Detecting internet search activity for mouth cancer in Ireland. (United States)

    Murray, G; O'Rourke, C; Hogan, J; Fenton, J E


    Mouth Cancer Awareness Day in Ireland was launched in September 2010 by survivors of the disease to promote public awareness of suspicious signs of oral cancer and to provide free dental examinations. To find out whether its introduction had increased public interest in the disease, we used Google Trends to find out how often users in Ireland had searched for "oral cancer" and "mouth cancer" across all Google domains between January 2005 and December 2013. The number of internet searches for these cancers has increased significantly (p increase in public awareness of mouth cancer could result in earlier presentation and better prognosis. Copyright © 2015 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

  20. Seroprevalence of chlamydial infection in cattle in Ireland. (United States)

    Wilson, Kim; Sammin, Donal; Harmeyer, Silke; Nath, Mintu; Livingstone, Morag; Longbottom, David


    Although few studies have investigated the prevalence of chlamydial infections in cattle, reported prevalence rates vary hugely. In order to assess the prevalence of this infection in cattle in Ireland, serum samples (100 herds, 20 samples/herd) collected for statutory screening for brucellosis were examined by soluble chlamydial antigen indirect ELISA. The assay detects antibodies to the two most common Chlamydiaceae spp. affecting cattle, namely Chlamydia abortus and Chlamydia pecorum. A total of 95 samples from 57 herds were seropositive, representing an observed prevalence rate of 4.75%. The parametric bootstrap estimate of the mean disease prevalence in the population was 6.04% (95%, CI 4.70-7.50). The results suggest the prevalence of chlamydial infection is low in cattle in Ireland. Copyright © 2012 Elsevier Ltd. All rights reserved.

  1. Ireland's recent contribution to the radiological literature; a bibliometric analysis

    LENUS (Irish Health Repository)

    Redmond, CE


    The aim of this study was to identify and analyse all articles published by Irish radiology departments in the medical literature since the year 2000. The PubMed database was searched to identify and review all articles published by radiologists based in the Republic of Ireland or Northern Ireland. Citation counts were then obtained and the top ten most cited articles were identified. There were 781 articles published during the study period. Of these, 558 (71%) were published in radiology journals and the remaining 223 (29%) were published in general medical journals. Abdominal radiology was the most represented sub-specialty (33% of all articles). There was a general trend of increased publications per year. Only 75 (9.6%) of articles were collaborative efforts by more than one radiology department. Irish radiology departments have a considerable research output and this has increased since the year 2000. More collaborative research between Irish radiology departments is encouraged

  2. Northern Ireland in Transition: The Role of Justice

    Directory of Open Access Journals (Sweden)

    Christian Mailhes


    Full Text Available All post-conflict societies switching to constitutional liberal democracies have to deal with their past through transitional justice mechanisms that offer to hear the victims, try the perpetrators of all types of abuses, introduce peace and reconciliation schemes. It is time for state and non-state organs to account for past crimes. Several countries have successfully tested such mechanisms. Northern Ireland is the ideal ground for transitional justice to operate but it dispels foreign tailor-made models. However, a number of major reforms and projects have addressed sensitive issues in the wake of the Good Friday Agreement. Two key institutions, the police and the criminal justice system, whose responsibility in the conflict was undeniable, have been reformed. Law and lawyers are concerned with these changes and the introduction of a Human Rights culture in Northern Ireland. A clear break with the past must be achieved for transitional justice mechanisms to work successfully.

  3. Comparison of family planning in Cuba and Ireland. (United States)

    Smyth, Suzie; Stronge, Shirley


    Family planning gives individuals and couples control and choice over the number of children they have and the timing of their births. Developments in reproductive health have resulted in major changes in the options for family planning, providing more choice and control over fertility. This article explores reproductive health in the Republic of Cuba and the Republic of Ireland, with a focus on contraceptive use and termination of pregnancy as methods of family planning. The predominant religion in both countries is Catholicism, which promotes the right to life of the unborn child. The two countries have adopted different approaches to the availability of both contraception and termination of pregnancy. Cuba has offered free access to contraception and termination of pregnancy since the 1960s to reduce maternal mortality. In Ireland, contraception was not widely available until 1995 and termination of pregnancy is available only in extremely limited circumstances.

  4. Identification and analysis of needs: the situation in Ireland

    International Nuclear Information System (INIS)

    Hone, C.


    In this paper I commence by outlining the arrangements for controlling and regulating the use of sources of ionizing radiation in Ireland. I then go on to describe the type and scope of training of various categories of personnel who are occupationally exposed. In doing so, I have distinguished between training received as part of general education and training programmes for different trades and professions and training given in dedicated courses. I have highlighted some of the shortcomings in training which, from the standpoint of the regulatory authority, have been noted and made suggestions as to how these might be remedied. I also briefly discuss the implications that the absence of a nuclear power facility in Ireland has for training

  5. Leptospirosis in Ireland: annual incidence and exposures associated with infection.

    LENUS (Irish Health Repository)

    Garvey, P


    SUMMARY Human leptospirosis is found throughout the world, albeit with a higher incidence in tropical regions. In temperate regions it is associated with certain occupational and recreational activities. This paper reports both on the incidence of human leptospirosis in Ireland and on possible associated exposures, using leptospirosis case notification, enhanced surveillance, hospital discharge data and death registrations. Based on official notification data, there was a threefold increase in the reported incidence of leptospirosis in Ireland between 1995-1999 and 2004-2009, which appears partially to be due to improved reporting. The exposures most associated with infection were those involving contact with livestock or water-based recreational sports, in particular kayaking. Advice on prevention should continue to be targeted in the first instance at these groups. The variety of potential transmission routes reported should inform clinicians to consider leptospirosis in individuals with a compatible clinical profile who were not from occupational groups historically considered at risk.

  6. Undergraduate Courses in Family Medicine in the UK, Ireland, the Netherlands and the Nordic Countries

    DEFF Research Database (Denmark)

    Larsen, Jan-Helge


    Almen medicin, Family Medicine, undergraduate Courses, the UK, Ireland, the Netherlands, the Nordic Countries......Almen medicin, Family Medicine, undergraduate Courses, the UK, Ireland, the Netherlands, the Nordic Countries...

  7. Radiological Protection Institute of Ireland activities and responsibilities

    International Nuclear Information System (INIS)


    This brochure describes the Radiological Protection Institute of Ireland's functions and responsibilities which relate principally to the monitoring of radioactivity in the environment and of radiation doses received by people occupationally or otherwise; regulation of the uses of ionising radiation in medicine, industry and elsewhere; assistance in developing national preparedness for response to a radiological emergency; and providing information and advice to government, other organisations and the general public on matters relating to ionising radiation. ills

  8. Using the IRRS to Strengthen Regulatory Competence in Ireland

    International Nuclear Information System (INIS)

    Smith, K.


    In 2015, Ireland underwent an IRRS (Integrated Regulatory Review Service) review mission. The purpose of the mission was to review Ireland’s radiation and nuclear safety regulatory framework and activities against the relevant IAEA safety standards, to report on the regulatory effectiveness and to exchange information and experience in the areas covered by the IRRS. The review mission was well-timed as there had been recent changes in the regulatory infrastructure with the merger of the Radiological Protection Institute of Ireland (RPII) and the Environmental Protection Agency (EPA) in 2014, as well as the upcoming implementation of the new Euratom Basic Safety Standards (BSS) Directive. The key objectives of the mission were to enhance the national legal, governmental and regulatory framework for nuclear and radiation safety, and national arrangements for emergency preparedness and response. The agreed scope of the review covered all relevant facilities and activities regulated in Ireland and also included medical exposures and public exposure to radon. In advance of the mission, Ireland completed a process of self-assessment and review. This process identified strengths and weaknesses in the national regulatory framework compared with the international standards. In addition to the value of having Ireland’s radiation protection framework peer reviewed by senior international experts, the mission helped to further strengthen links between all the national bodies (government, licensees, regulatory) with a role in the regulation of radiation safety. The findings from the IRRS review team’s objective evaluation of Ireland’s regulatory infrastructure are being used to prioritise actions for strengthening the regulatory framework, to provide input into the transposition of the Euratom BSS, and to support the revision of the national emergency plan for nuclear accidents. It is planned to have addressed the findings of the IRRS mission in advance of a follow up

  9. The bedrock electrical conductivity structure of Northern Ireland


    Beamish, David


    An airborne geophysical survey of the whole of Northern Ireland has provided over 4.8 M estimates of the bedrock conductivity over the wide range of geological formations present. This study investigates how such data can be used to provide additional knowledge in relation to existing digital geological map information. A by-product of the analysis is a simplification of the spatially aggregated information obtained in such surveys. The methodology used is a GIS-based attribution of the condu...

  10. Censorship in the two Irelands 1922-1939


    Martin, Peter


    This thesis was based on archival research in the repositories named in the bibliography. This was supplemented by secondary sources where primary sources were inadequate or unavailable. Archival research has been supplemented by statistical analysis. In the case of film censorship this has been compiled from the Record of films Censored, the Film Censor’s Notebooks and the Reserve Books in the National Archives of Ireland. In the case of book censorship a database was prepared of all the ...

  11. Education, Training and the Role of Logistic Managers in Ireland


    Mangan, John; Gregory, Orla


    The paper is based on the analysis of the responses of a questionnaire survey of logistics managers working in manufacturing firms in Ireland. The objectives of the survey were to establish the educational and training needs of the practicing logistics manager. The questionnaire was designed to address issues including the various logistics practices undertaken by the respondents' company and the time spent by respondents on these activities; the skills currently required by logistics manager...

  12. The consequences of Ireland's culture of medical migration. (United States)

    Humphries, Niamh; Crowe, Sophie; McDermott, Cian; McAleese, Sara; Brugha, Ruairi


    In recent years, Ireland has experienced a large-scale, outward migration of doctors. This presents a challenge for national policy makers and workforce planners seeking to build a self-sufficient medical workforce that trains and retains enough doctors to meet demand. Although, traditionally, medical migration has been considered beneficial to the Irish health system, austerity has brought a greater level of uncertainty to the health system and, with it, a need to reappraise the professional culture of migration and its impact on the Irish health system. This paper illustrates how a culture of migration informs career and migration plans. It draws on quantitative data-registration and migration data from source and destination countries-and qualitative data-in-depth interviews with 50 doctors who had undertaken postgraduate medical training in Ireland. Of 50 respondents, 42 highlighted the importance of migration. The culture of medical migration rests on two assumptions-that international training/experience is beneficial to all doctors and that those who emigrate will return to Ireland with additional skills and experience. This assumption of return is challenged by a new generation of doctors whose professional lives have been shaped by globalisation and by austerity. Global comparisons reveal the comparatively poor working conditions, training and career opportunities in Ireland and the relative attractiveness of a permanent career abroad. In light of these changes, there is a need to critically appraise the culture of medical migration to determine if and in what circumstances migration is appropriate to the needs of the Irish health system. The paper considers the need to reappraise the culture of medical migration and the widespread emigration that it promotes.

  13. Listening to Identity: Music in 21st century Ireland


    Blake, Andrew


    This paper firstly reviews recent scholarship on music and identity in Ireland. The review detects and discusses a set of issues around the identification of genre and nationality in a country which continues to experience a rapidly changing population structure, against which the mapping of a communal Irishness onto existing categories such as ‘traditional music’ becomes increasingly difficult. Against the grain of this recent scholarship, the paper argues that, in a postmodern and globalise...

  14. Mental health law profile on the Republic of Ireland. (United States)

    Datta, Anna; Frewen, Justin


    This article provides a brief overview of the legislation that has been enacted in Ireland with respect to mental health, in particular the 2001 Mental Health Act. Although that Act was a positive step towards developing an Irish mental health service that protects the human rights of service users, a number of concerns remain, including issues related to consent and capacity, involuntary out-patient treatment and admission, the adversarial nature and timing of tribunals, and the lack of safeguards for voluntary patients.

  15. A National Study of Wellbeing of Hospital Doctors in Ireland


    Hayes, Blanaid


    The working environment for hospital doctors in Ireland has undergone radical change in recent years with hospital posts becoming unattractive to doctors in training and to consultants. For young medical graduates, the tensions between training requirements and service demands have contributed to a ‘brain drain’ with over half leaving to work abroad after graduation. Many consultant posts are vacant or are filled on a temporary basis, impacting on the quality of patient care. This study se...

  16. Incidence of lead poisoning in calves in Northern Ireland

    Energy Technology Data Exchange (ETDEWEB)

    Todd, J R


    The concentrations of lead in kidneys of slaughtered calves from three slaughterhouses in Northern Ireland were analyzed for lead content to determine the frequency of lead-poisoning-attributable deaths. It was found that about 4% of the calves had concentrations of lead exceeding 25 ppm in the kidney, a level generally accepted to indicate lethality. This finding is substantially higher than previous estimates. 6 references, 1 table.

  17. Ireland's medical brain drain: migration intentions of Irish medical students.

    LENUS (Irish Health Repository)

    Gouda, Pishoy


    To provide the optimum level of healthcare, it is important that the supply of well-trained doctors meets the demand. However, despite many initiatives, Ireland continues to have a shortfall of physicians, which has been projected to persist. Our study aimed to investigate the migration intentions of Irish medical students and identify the factors that influence their decisions in order to design appropriate interventions to sustain the supply of trained doctors in order to maintain a viable medical system.

  18. Traumatic brain injury pharmacological treatment: recommendations

    Directory of Open Access Journals (Sweden)

    Renato Anghinah

    Full Text Available ABSTRACT This article presents the recommendations on the pharmacological treatment employed in traumatic brain injury (TBI at the outpatient clinic of the Cognitive Rehabilitation after TBI Service of the Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil. A systematic assessment of the consensus reached in other countries, and of articles on TBI available in the PUBMED and LILACS medical databases, was carried out. We offer recommendations of pharmacological treatments in patients after TBI with different symptoms.

  19. Ptolemy's Britain and Ireland: A New Digital Reconstruction (United States)

    Abshire, Corey; Durham, Anthony; Gusev, Dmitri A.; Stafeyev, Sergey K.


    In this paper, we expand application of our mathematical methods for translating ancient coordinates from the classical Geography by Claudius Ptolemy into modern coordinates from India and Arabia to Britain and Ireland, historically important islands on the periphery of the ancient Roman Empire. The methods include triangulation and flocking with subsequent Bayesian correction. The results of our work can be conveniently visualized in modern GIS tools, such as ArcGIS, QGIS, and Google Earth. The enhancements we have made include a novel technique for handling tentatively identified points. We compare the precision of reconstruction achieved for Ptolemy's Britain and Ireland with the precisions that we had computed earlier for his India before the Ganges and three provinces of Arabia. We also provide improved validation and comparison amongst the methods applied. We compare our results with the prior work, while utilizing knowledge from such important ancient sources as the Antonine Itinerary, Tabula Peutingeriana, and the Ravenna Cosmography. The new digital reconstruction of Claudius Ptolemy's Britain and Ireland presented in this paper, along with the accompanying linguistic analysis of ancient toponyms, contributes to improvement of understanding of our cultural cartographic heritage by making it easier to study the ancient world using the popular and accessible GIS programs.

  20. Epilepsy in Ireland: towards the primary-tertiary care continuum. (United States)

    Varley, Jarlath; Delanty, Norman; Normand, Charles; Coyne, Imelda; McQuaid, Louise; Collins, Claire; Boland, Michael; Grimson, Jane; Fitzsimons, Mary


    Epilepsy is a chronic neurological disease affecting people of every age, gender, race and socio-economic background. The diagnosis and optimal management relies on contribution from a number of healthcare disciplines in a variety of healthcare settings. To explore the interface between primary care and specialist epilepsy services in Ireland. Using appreciative inquiry, focus groups were held with healthcare professionals (n=33) from both primary and tertiary epilepsy specialist services in Ireland. There are significant challenges to delivering a consistent high standard of epilepsy care in Ireland. The barriers that were identified are: the stigma of epilepsy, unequal access to care services, insufficient human resources, unclear communication between primary-tertiary services and lack of knowledge. Improving the management of people with epilepsy requires reconfiguration of the primary-tertiary interface and establishing clearly defined roles and formalised clinical pathways. Such initiatives require resources in the form of further education and training and increased usage of information communication technology (ICT). Epilepsy services across the primary-tertiary interface can be significantly enhanced through the implementation of a shared model of care underpinned by an electronic patient record (EPR) system and information communication technology (ICT). Better chronic disease management has the potential to halt the progression of epilepsy with ensuing benefits for patients and the healthcare system. Copyright 2009 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

  1. National survey of CT colonography practice in Ireland

    LENUS (Irish Health Repository)

    Smyth, A.E.


    CT Colonography was first introduced to Ireland in 1999. Our aim of this study is to review current CT Colonography practices in the Republic of Ireland. A questionnaire on CT Colonography practice was sent to all non-maternity adult radiology departments in the Republic of Ireland with a CT scanner. The results are interpreted in the context of the recommendations on CT Colonography quality standards as published by the European Society of Gastrointestinal and Abdominal Radiology (ESGAR) consensus statement in the journal of European Radiology in 2013. Thirty centres provide CT Colonography; 21 of which responded (70%). Each centre performs median 90 studies per year; the majority follow accepted patient preparation and image acquisition protocols. Seventy-six percent of the centres repsonded that the majority of patients imaged are symptomatic. Of the 51 consultant radiologists reading CT Colonography, 37 (73%) have attended a CT Colonography course. In 17 (81%) of the centres the studies are single read although 81% of the centres have access to a second radiologist’s opinion. Fourteen (67%) of the centres reported limited access to CT scanner time as the major limiting factor to expanding their service. CT Colonography is widely

  2. Supervised classification of continental shelf sediment off western Donegal, Ireland (United States)

    Monteys, X.; Craven, K.; McCarron, S. G.


    Managing human impacts on marine ecosystems requires natural regions to be identified and mapped over a range of hierarchically nested scales. In recent years (2000-present) the Irish National Seabed Survey (INSS) and Integrated Mapping for the Sustainable Development of Ireland's Marine Resources programme (INFOMAR) (Geological Survey Ireland and Marine Institute collaborations) has provided unprecedented quantities of high quality data on Ireland's offshore territories. The increasing availability of large, detailed digital representations of these environments requires the application of objective and quantitative analyses. This study presents results of a new approach for sea floor sediment mapping based on an integrated analysis of INFOMAR multibeam bathymetric data (including the derivatives of slope and relative position), backscatter data (including derivatives of angular response analysis) and sediment groundtruthing over the continental shelf, west of Donegal. It applies a Geographic-Object-Based Image Analysis software package to provide a supervised classification of the surface sediment. This approach can provide a statistically robust, high resolution classification of the seafloor. Initial results display a differentiation of sediment classes and a reduction in artefacts from previously applied methodologies. These results indicate a methodology that could be used during physical habitat mapping and classification of marine environments.

  3. A review of traditional uses, phytochemistry and pharmacology of Portulaca oleracea L. (United States)

    Iranshahy, Milad; Javadi, Behjat; Iranshahi, Mehrdad; Jahanbakhsh, Seyedeh Pardis; Mahyari, Saman; Hassani, Faezeh Vahdati; Karimi, Gholamreza


    Portulaca oleracea L. is a widespread medicinal plant that is used not only as an edible plant, but also as a traditional medicine for alleviating a wide spectrum of diseases. It is a well-known plant in the European Traditional Medicine. PA is mentioned by Dioscorides (40-90 CE), with the name of "andrachne". In this study, we provide detailed information on botany, traditional uses, phytochemistry, pharmacological uses, pharmacokinetics and safety of P. oleracea. An extensive search on electronic databases including PubMed, Web of Science, Google Scholar, ScienceDirect, Scopus, conference papers, local herbal encyclopedias, articles, books (in English, French, Arabic, Persian, etc.) and also a number of unpublished handwritten manuscripts was done to find articles have been published between 1956 and 2015 on pharmacology and phytochemistry of P. oleracea. P. oleracea has been addressed in De Materia Medica as an astringent, and a remedy for headaches, inflammation of the eyes and other organs, burning of the stomach, erysipela, disorders of the bladder, numbness of the teeth, excessive sexual desire, burning fevers, worms, dysentery, hemorrhoids, eruptions of blood, and bites. Phytochemical investigations revealed that this plant a wide range of secondary metabolites including alkaloids, terpenoids, flavonoids and organic acids. The most important pharmacological activities are renoprotective activities and effects on metabolism. P. oleracea could successfully decrease blood glucose and lipid profile of patients with metabolic syndrome. The safety of P. oleracea has been reported in many clinical trials. Modern pharmacological studies have now proven many traditional uses of P. oleracea, including anti-hyperglycemic and anti-hyperlipidemic, renoprotective and hepatoprotective effects. In addition, in many clinical trials P. oleracea showed no adverse effects and constipation was reported as the most frequent adverse effect. Copyright © 2017 Elsevier Ireland Ltd

  4. Botany, traditional uses, phytochemistry and pharmacology of Apocynum venetum L. (Luobuma): A review. (United States)

    Xie, Wenyan; Zhang, Xiaoying; Wang, Tian; Hu, Jianjun


    pharmacological effects and the mode of actions. Further safety assessments and clinical trials should be performed before it can be integrated into medicinal practices. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  5. Domestic violence education for UK and Ireland undergraduate dental students: a five-year perspective. (United States)

    Patel, Neil; Bailey, Edmund; Mahdmina, Ayeh; Lomax, Alastair; Coulthard, Paul


    The purpose of this cross-sectional study was to ascertain whether undergraduate dental students in the United Kingdom and Ireland are receiving formal teaching on recognizing and managing domestic violence (DV) as part of their curricula. A questionnaire was sent to all dental schools in the UK and Ireland in 2007 and again in 2012, requesting information on whether the subject was taught, by which specialty it was taught, and whether schools felt it was important to include in the curriculum. In 2007, twelve of the fifteen dental schools completed and returned the questionnaire, for a response rate of 80 percent; in 2012, eleven of the sixteen dental schools responded, for a response rate of 69 percent. The main findings were that, in 2007, 50 percent of the responding schools were providing teaching about DV and the majority of this teaching was delivered by oral surgery and pediatric dentistry departments. In 2012, only 45 percent of the responding schools were teaching DV, with 60 percent of this teaching being delivered by pediatric dentists. This study's findings suggest that DV is an undertaught area in UK and Irish undergraduate dental curricula. Some schools recognized the importance of DV teaching; however, they have been unable to implement it because of a full curriculum and lack of appropriately trained staff amongst other reasons.

  6. Leadership and leadership development within the profession of physiotherapy in Ireland. (United States)

    McGowan, Emer; Stokes, Emma


    Health service reform, physiotherapy graduate unemployment, and the impending introduction of state regulation mean that physiotherapists in Ireland today are facing many challenges. Leadership is needed to ensure that the profession will be able to adapt to the demands and inevitable changes ahead. To investigate the perceptions of physiotherapists in Ireland of leadership and leadership characteristics, and to explore their participation in leadership development training. In this cross-sectional nationwide study, an Internet-based survey was administered via e-mail to members of the Irish Society of Chartered Physiotherapists (n = 2,787). There were 615 responses to the survey. A high proportion of respondents (74.0%) perceived themselves to be a leader. Factors associated with self-declaration as a leader were time since graduation, highest qualification attained, and leadership training. Leadership training was also associated with placing greater importance on achieving a leadership position. Some form of leadership training had been completed by 41.5% of respondents. Communication and professionalism were the most highly rated leadership characteristics in all three settings. Physiotherapists who have had leadership training were more likely to perceive themselves to be leaders. Leadership training may support physiotherapists to assume leadership roles both clinically and nonclinically.

  7. Ethnomedicinal uses, phytochemistry and pharmacological properties of the genus Boerhavia. (United States)

    Patil, Kapil S; Bhalsing, Sanjivani R


    The genus Boerhavia is widely distributed in tropical, subtropical and temperate regions of the world including Mexico, America, Africa, Asia, Indian Ocean Islands, Pacific Islands and Australia. The genus Boerhavia is extensively used by local peoples and medicinal practitioners for treatments of hepatitis, urinary disorders, gastro intestinal diseases, inflammations, skin problems, infectious diseases and asthma. Present review focused on traditional uses, phytochemistry, pharmacology and toxicology of Boerhavia genus to support potential scope for advance ethnopharmacological study. Information on the Boerhavia species was collected from classical books on medicinal plants, pharmacopoeias and scientific databases like PubMed, Scopus, GoogleScholar, Web of Science and others. Also scientific literatures based on ethnomedicinal surveys, Ph.D. and M.Sc. dissertations, published papers from Elsevier, Taylor and Francis, Springer, ACS as well as Wiley publishers and reports by government bodies and documentations were assessed. A total of 180 compounds from Boerhavia genus were isolated of which B. diffusa alone shared around 131 compounds and for most of which it is currently an exclusive source. In the genus, phenolic glycosides and flavonoids contribute approximately 97 compounds. These includes eupalitin, rotenoids like boeravinones, coccineons, alkaloid i.e. betanin and punarnavine etc., showing vital pharmaceutical activities such as anticancer, anti-inflammatory, antioxidant and immunomodulatory. Boerhavia is an important genus with wide range of medicinal uses. However, most of the available scientific literatures have lacked relevant doses, duration and positive controls for examining bioefficacy of extracts and its active compounds. In some studies, taxonomic errors were encountered. Moreover, there is need for accurate methods in testing the safety and ethnomedicinal validity of Boerhavia species. Copyright © 2016. Published by Elsevier Ireland Ltd.

  8. Older people--recipients but also providers of informal care: an analysis among community samples in the Republic of Ireland and Northern Ireland.

    LENUS (Irish Health Repository)

    McGee, Hannah M


    Data on both the provision and receipt of informal care among populations of older adults are limited. Patterns of both informal care provided and received by older adults in the Republic of Ireland (RoI) and Northern Ireland (NI) were evaluated. A cross-sectional community-based population survey was conducted. Randomly selected older people (aged 65+, n = 2033, mean age (standard deviation): 74.1 years (6.8), 43% men, 68% response rate) provided information on the provision and receipt of care, its location, and the person(s) who provided the care. Twelve per cent of the sample (251\\/2033) identified themselves as informal caregivers (8% RoI and 17% NI). Caregivers were more likely to be women, married, have less education and have less functional impairment. Forty-nine per cent (1033\\/2033, 49% RoI and 48% NI) reported receiving some form of care in the past year. Care recipients were more likely to be older, married, have more functional impairment, and poorer self-rated health. Receiving regular informal care (help at least once a week) from a non-resident relative was the most common form of help received [28% overall (578\\/2033); 27% RoI and 30% NI]. Five per cent (n = 102\\/2033) of the sample reported both providing and receiving informal care. Levels of informal care provided by community-dwelling older adults were notably higher than reported in single-item national census questions. The balance of formal and informal health and social care will become increasingly important as populations age. It is essential, therefore, to evaluate factors facilitating or impeding informal care delivery.

  9. Sarcoidosis in Ireland: regional differences in prevalence and mortality from 1996-2005.

    LENUS (Irish Health Repository)

    Nicholson, T T


    Sarcoidosis is a common multisystem disease of unknown cause and Ireland is among the countries with the highest reported prevalence of disease worldwide. Despite this, reports on the geographical distribution of disease and differences in mortality due to sarcoidosis within Northern Ireland (NI) and the Republic of Ireland (ROI) are currently lacking.

  10. Invasive Group A streptococcal disease in Ireland, 2004 to 2010.

    LENUS (Irish Health Repository)

    Martin, J


    Invasive group A streptococcal infections (iGAS) are a major clinical and public health challenge. iGAS is a notifiable disease in Ireland since 2004. The aim of this paper is to describe the epidemiology of iGAS in Ireland for the first time over the seven-year period from 2004 to 2010. The Irish national electronic infectious disease reporting system was used by laboratories to enter the source of iGAS isolates, and by departments of public health to enter clinical and epidemiological details. We extracted and analysed data from 1 January 2004 to 31 December 2010. Over the study period, 400 iGAS cases were notified. The annual incidence of iGAS doubled, from 0.8 per 100,000 population in 2004 to 1.6 in 2008, and then remained the same in 2009 and 2010. The reported average annual incidence rates were highest among children up to five years of age (2.3\\/100,000) and adults aged over 60 years (3.2\\/100,000). The most common risk factors associated with iGAS were skin lesions or wounds. Of the 174 people for whom clinical syndrome information was available, 28 (16%) cases presented with streptococcal toxic shock syndrome and 19 (11%) with necrotising fasciitis. Of the 141 cases for whom seven-day outcomes were recorded, 11 people died with iGAS identified as the main cause of death (seven-day case fatality rate 8%). The notification rate of iGAS in Ireland was lower than that reported in the United Kingdom, Nordic countries and North America but higher than southern and eastern European countries. The reasons for lower notification rates in Ireland compared with other countries may be due to a real difference in incidence, possibly due to prescribing practices, or due to artefacts resulting from the specific Irish case definition and\\/or low reporting in the early stages of a new surveillance system. iGAS disease remains an uncommon but potentially severe disease in Ireland. Ongoing surveillance is required in order to undertake appropriate control measures and

  11. Ireland's contribution to orthopaedic literature: a bibliometric analysis. (United States)

    Kennedy, C; O Sullivan, P; Bilal, M; Walsh, A


    Bibliometric analysis of scientific performance within a country or speciality, facilitate the recognition of factors that may further enhance research activity and performance. Our aim was to illicit the current state of Irelands orthopaedic research output in terms of quantity and quality. We performed a retrospective bibliometric analysis of all Irish orthopaedic publications over the past 5 years, in the top 20 peer-reviewed orthopaedic journals. Utilising the MEDLINE database, each journal was evaluated for articles that were published over the study period. Reviews, editorials, reports and letters were excluded. Each article abstract was analysed for research content, and country of origin. A nation's mean IF was defined by multiplying each journal's IF by the number of articles. Publications per million (PmP) was calculated by dividing the total number of publications by the population of each country. We analysed a total of 25,595 article abstracts. Ireland contributed 109 articles in total (0.42% of all articles), however ranking according to population per million was 10th worldwide. Ireland ranked 18th worldwide in relation to mean impact factor, which was 2.91 over the study period. Ireland published in 16 of the top 20 journals, 9 of these were of European origin, and 1 of the top 5 was of American origin. In total, 61 Irish articles were assignable to clinical orthopaedic units. Clinical based studies (randomised controlled trials, observational, and epidemiology/bibliometric articles) and research based studies (In vivo, In vitro, and biomechanical) numbered 76 (69.7%) and 33 (30.2%) articles, respectively. This study provides a novel overview of current Irish orthopaedic related research, and how our standards translate to the worldwide orthopaedic community. In order to maintain our publication productivity, academic research should continue to be encouraged at post graduate level. Copyright © 2013 Royal College of Surgeons of Edinburgh

  12. Delirium in the elderly: A systematic review of pharmacological and non-pharmacological treatments

    Directory of Open Access Journals (Sweden)

    Cecília Carboni Tardelli Cerveira

    Full Text Available ABSTRACT Delirium is a common disorder associated with poor prognosis, especially in the elderly. The impact of different treatment approaches for delirium on morbimortality and long-term welfare is not completely understood. OBJECTIVE: To determine the efficacy of pharmacological and non-pharmacological treatments in elderly patients with delirium. METHODS: This systematic review compared pharmacological and non-pharmacological treatments in patients over 60 years old with delirium. Databases used were: MEDLINE (PubMed, EMBASE, Cochrane CENTRAL and LILACS from inception to January 6th, 2016. RESULTS: A total of ten articles were selected. The six non-pharmacological intervention studies showed no impact on duration of delirium, mortality or institutionalization, but a decrease in severity of delirium and improvement in medium-term cognitive function were observed. The most commonly used interventions were temporal-spatial orientation, orientation to self and others, early mobilization and sleep hygiene. The four studies with pharmacological interventions found that rivastigmine reduced the duration of delirium, improved cognitive function and reduced caregiver burden; olanzapine and haloperidol decreased the severity of delirium; droperidol reduced length of hospitalization and improved delirium remission rate. CONCLUSION: Although the pharmacological approach has been used in the treatment of delirium among elderly, there have been few studies assessing its efficacy, involving a small number of patients. However, the improvements in delirium duration and severity suggest these drugs are effective in treating the condition. Once delirium has developed, non-pharmacological treatment seems less effective in controlling symptoms, and there is a lack of studies describing different non-pharmacological interventions.

  13. Traditional uses, botany, phytochemistry, pharmacology and toxicology of Panax notoginseng (Burk.) F.H. Chen: A review. (United States)

    Wang, Ting; Guo, Rixin; Zhou, Guohong; Zhou, Xidan; Kou, Zhenzhen; Sui, Feng; Li, Chun; Tang, Liying; Wang, Zhuju


    Panax notoginseng (Burk.) F.H. Chen is a widely used traditional Chinese medicine known as Sanqi or Tianqi in China. This plant, which is distributed primarily in the southwest of China, has wide-ranging pharmacological effects and can be used to treat cardiovascular diseases, pain, inflammation and trauma as well as internal and external bleeding due to injury. This paper provides up-to-date information on investigations of this plant, including its botany, ethnopharmacology, phytochemistry, pharmacology and toxicology. The possible uses and perspectives for future investigation of this plant are also discussed. The relevant information on Panax notoginseng (Burk.) F.H. Chen was collected from numerous resources, including classic books about Chinese herbal medicine, and scientific databases, including Pubmed, SciFinder, ACS, Ebsco, Elsevier, Taylor, Wiley and CNKI. More than 200 chemical compounds have been isolated from Panax notoginseng (Burk.) F.H. Chen, including saponins, flavonoids and cyclopeptides. The plant has pharmacological effects on the cardiovascular system, immune system as well as anti-inflammatory, anti-atherosclerotic, haemostatic and anti-tumour activities, etc. Panax notoginseng is a valuable traditional Chinese medical herb with multiple pharmacological effects. This review summarizes the botany, ethnopharmacology, phytochemistry, pharmacology and toxicology of P. notoginseng, and presents the constituents and their corresponding chemical structures found in P. notoginseng comprehensively for the first time. Future research into its phytochemistry of bio-active components should be performed by using bioactivity-guided isolation strategies. Further work on elucidation of the structure-function relationship among saponins, understanding of multi-target network pharmacology of P. notoginseng, as well as developing its new clinical usage and comprehensive utilize will enhance the therapeutic potentials of P. notoginseng. Copyright © 2016

  14. Animal Health Ireland: providing national leadership and coordination of non-regulatory animal health issues in Ireland. (United States)

    More, S J; Doherty, M L; Downey, L; McKenzie, K; Devitt, C; O'Flaherty, J


    Livestock production plays an important role in the Irish economy. Regulatory animal health issues are the responsibility of government, but until recently there has been no national coordination of non-regulatory animal health issues. This gap has recently been filled with the establishment of Animal Health Ireland (AHI), a not-for-profit, partnership-based organisation providing national leadership and coordination of non-regulatory animal health issues in Ireland. Animal Health Ireland provides benefits to livestock producers and processors by providing the knowledge, education and coordination required to establish effective control strategies, both on-farm and nationally. This paper presents a brief overview of the context for AHI, and of its establishment and initial activities. Non-regulatory animal health issues have been prioritised. A series of work programmes (each focusing on a high-priority issue) have been established. Partnership is critical to success, both for AHI as an organisation and for effective farm-level transfer of knowledge. This model for national leadership and coordination of non-regulatory animal health issues may be of relevance elsewhere.

  15. Pharmacological therapy of chronic obstructive pulmonary disease

    African Journals Online (AJOL)

    patients with COPD require pharmacological therapy. ... pulmonary dysfunction. Clearly the patient's tolerance to the various drugs will influence the choice of long-term maintenance treatment. The other important factor in the .... blocking cervical immune responses might leave her less protected against other infections.

  16. Multidimensional Screening as a Pharmacology Laboratory Experience. (United States)

    Malone, Marvin H.; And Others


    A multidimensional pharmacodynamic screening experiment that addresses drug interaction is included in the pharmacology-toxicology laboratory experience of pharmacy students at the University of the Pacific. The student handout with directions for the procedure is reproduced, drug compounds tested are listed, and laboratory evaluation results are…

  17. Radioreceptor assay: theory and applications to pharmacology

    International Nuclear Information System (INIS)

    Perret, G.; Simon, P.


    The aim of the first part of this work is to present the theory of the radioreceptor assay and to compare it to the other techniques of radioanalysis (radioimmunoassay, competitive protein binding assays). The technology of the radioreceptor assay is then presented and its components (preparation of the receptors, radioligand, incubation medium) are described. The analytical characteristics of the radioreceptor assay (specificity, sensitivity, reproductibility, accuracy) and the pharmacological significance of the results are discussed. The second part is devoted to the description of the radioreceptor assays of some pharmacological classes (neuroleptics, tricyclic antidepressants, benzodiazepines, β-blockers, anticholinergic drugs) and to their use in therapeutic drug monitoring. In conclusion, by their nature, radioreceptor assays are highly sensitive, reliable, precise, accurate and simple to perform. Their chief disadvantage relates to specificity, since any substance having an appreciable affinity to the receptor site will displace the specifically bound radioligand. Paradoxically in some cases, this lack of specificity may be advantageous in that it allows for the detection of not only the apparent compound but of active metabolites and endogenous receptor agonists as well and in that radioreceptors assays can be devised for a whole pharmacological class and not only for one drug as it is the case for classical physico-chemical techniques. For all these reasons future of radioreceptor assay in pharmacology appears promising [fr

  18. Ethnomedicinal uses and pharmacological activities of Croton ...

    African Journals Online (AJOL)

    Abstract. Purpose: To provide an overview of the ethnomedicinal uses and ... calls for detailed phytochemical and pharmacological properties of the species aimed at identifying the ... urban communities throughout its native ... sized, densely leafy tree reaching 15 m tall [17] ..... Williams College, United States; 1998; p 133.

  19. Pharmacological Interventions for Students with ADD. (United States)

    Austin, Vance L.


    A review of the research on pharmacological interventions for students with attention deficit disorder finds that psychostimulants such as methylphenidate (Ritalin) are effective in improving focus and impulse control, but should be used in conjunction with psychosocial and behavioral interventions. Comprehensive medical screenings and guidelines…

  20. Jatropha Tanjorensis - Review of Phytochemistry, Pharmacology ...

    African Journals Online (AJOL)

    Based on the findings of this work, future study on the phytochemistry and chemical constituents in relation to certain other biological activities are required to fully understand the phytochemical and complex pharmacological effect of the plant specie. Further work to isolate active compounds from the plant is also necessary.

  1. Current status and challenges of cytokine pharmacology

    Czech Academy of Sciences Publication Activity Database

    Zídek, Zdeněk; Anzenbacher, P.; Kmoníčková, Eva


    Roč. 157, č. 3 (2009), s. 342-361 ISSN 0007-1188 R&D Projects: GA ČR GA305/08/0535; GA MŠk 1M0508 Institutional research plan: CEZ:AV0Z50390512 Keywords : cytokines * immunotherapy * immunopharmacology Subject RIV: FR - Pharmacology ; Medidal Chemistry Impact factor: 5.204, year: 2009

  2. International Journal of Herbs and Pharmacological Research

    African Journals Online (AJOL)

    International Journal of Herbs and Pharmacological Research (IJHPR) [ISSN: 2315-537X; E- ISSN: 2384-6836] is a peer reviewed journal publication of Anthonio Research Center. The Journal is intended to serve as a medium for the publication of research findings in the field of Herbal medication in developing countries ...

  3. Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology. (United States)

    Pirazzini, Marco; Rossetto, Ornella; Eleopra, Roberto; Montecucco, Cesare


    The study of botulinum neurotoxins (BoNT) is rapidly progressing in many aspects. Novel BoNTs are being discovered owing to next generation sequencing, but their biologic and pharmacological properties remain largely unknown. The molecular structure of the large protein complexes that the toxin forms with accessory proteins, which are included in some BoNT type A1 and B1 pharmacological preparations, have been determined. By far the largest effort has been dedicated to the testing and validation of BoNTs as therapeutic agents in an ever increasing number of applications, including pain therapy. BoNT type A1 has been also exploited in a variety of cosmetic treatments, alone or in combination with other agents, and this specific market has reached the size of the one dedicated to the treatment of medical syndromes. The pharmacological properties and mode of action of BoNTs have shed light on general principles of neuronal transport and protein-protein interactions and are stimulating basic science studies. Moreover, the wide array of BoNTs discovered and to be discovered and the production of recombinant BoNTs endowed with specific properties suggest novel uses in therapeutics with increasing disease/symptom specifity. These recent developments are reviewed here to provide an updated picture of the biologic mechanism of action of BoNTs, of their increasing use in pharmacology and in cosmetics, and of their toxicology. Copyright © 2017 by The Author(s).

  4. International Journal of Herbs and Pharmacological Research ...

    African Journals Online (AJOL)

    PROMOTING ACCESS TO AFRICAN RESEARCH ... International Journal of Herbs and Pharmacological Research: Advanced Search ... either term; e.g., education OR research; Use parentheses to create more complex queries; ... African Journal of Biomedical Research, African Journal of Biotechnology, African Journal of ...

  5. Pharmacological management of chronic obstructive pulmonary ...

    African Journals Online (AJOL)

    The main objective of treatment is to relieve daily symptoms, improve quality of life and importantly decrease the risk of future exacerbations. Current guidelines are based on grade A and B evidence. Pneumococcal and annual influenza vaccinations are encouraged. A holistic approach that augments pharmacological ...

  6. Emerging pharmacological therapy for functional dyspepsia. (United States)

    Hojo, Mariko; Nagahara, Akihito; Asaoka, Daisuke; Watanabe, Sumio


    Functional dyspepsia (FD) is a multifactorial disease with complex underlying pathophysiology. To date, there is no established treatment for FD. This review summarizes recent progress in pharmacological therapy for the disease. A newly developed drug, acotiamide, is expected to improve symptoms of postprandial distress syndrome. Herbal medicines are also expected to become options for FD treatment.

  7. Clinical pharmacology of novel anticancer drug formulations

    NARCIS (Netherlands)

    Stuurman, F.E.


    Studies outlined in this thesis describe the impact of drug formulations on pharmacology of anticancer drugs. It consists of four parts and starts with a review describing the mechanisms of low oral bioavailability of anti-cancer drugs and strategies for improvement of the bioavailability. The

  8. Kinship and interaction in neuromuscular pharmacology

    NARCIS (Netherlands)

    Schiere, Sjouke


    The background of this thesis is presented in the introductory chapters and stafts with a brief history of neuromuscular relaxants. It is followed by a short description of the neuromuscular physiology and pharmacology in chapters 2 and 3, respectively. In chapter 4 the aim of the thesis is

  9. Pharmaceutical and pharmacological approaches for bioavailability

    Indian Academy of Sciences (India)

    Much research has been done to determine drug–drug and herb–drug interactions for improving the bioavailability of etoposide. The present article gives insight on pharmaceutical and pharmacological attempts made from time to time to overcome the erratic inter- and intra-patient variability for improving the bioavailability ...

  10. Chemical constituents, and pharmacological and toxicological ...

    African Journals Online (AJOL)

    Methods: A large number of research articles related to “Cynomorium songaricum” “pharmacological effects” .... contents in C. songaricum at different stages of its growth are varied in a .... Oral water-soluble polysaccharides of C. ... tested strains, mouse somatic cells and germ cells. .... change under the influence of heating.

  11. Pharmacological Evaluation of the Antidiarrhoeal Activity of ...

    African Journals Online (AJOL)

    This study presents the pharmacological evaluation of the effects of intraperitoneal injection of aqueous seed extract of Aframomum melegueta (AM) on diarrhoea, intestinal fluid secretion and gastrointestinal transit time, induced by castor oil in rodents. The results of the study revealed that AM (50-200 mg/kg) produced a ...

  12. Some Pharmacological Aspects of Antimalarial Drugs

    African Journals Online (AJOL)


    Jun 15, 1974 ... Some Pharmacological Aspects of Antimalarial. Drugs. D.BOTHA. SUMMARY. A short review is given of antimalarial drugs currently in use. S. Air. Med. l., 48, 1263 (1974). CLASSIFICATION. The chemotherapy of malaria may be conveniently classi- fied as (i) casual prophylaxis; (ii) suppressive treatment;.

  13. Systems Pharmacology in Small Molecular Drug Discovery

    Directory of Open Access Journals (Sweden)

    Wei Zhou


    Full Text Available Drug discovery is a risky, costly and time-consuming process depending on multidisciplinary methods to create safe and effective medicines. Although considerable progress has been made by high-throughput screening methods in drug design, the cost of developing contemporary approved drugs did not match that in the past decade. The major reason is the late-stage clinical failures in Phases II and III because of the complicated interactions between drug-specific, human body and environmental aspects affecting the safety and efficacy of a drug. There is a growing hope that systems-level consideration may provide a new perspective to overcome such current difficulties of drug discovery and development. The systems pharmacology method emerged as a holistic approach and has attracted more and more attention recently. The applications of systems pharmacology not only provide the pharmacodynamic evaluation and target identification of drug molecules, but also give a systems-level of understanding the interaction mechanism between drugs and complex disease. Therefore, the present review is an attempt to introduce how holistic systems pharmacology that integrated in silico ADME/T (i.e., absorption, distribution, metabolism, excretion and toxicity, target fishing and network pharmacology facilitates the discovery of small molecular drugs at the system level.

  14. Ethnobotanical, phytochemical and pharmacological properties of ...

    African Journals Online (AJOL)

    Purpose: To present an overview of the ethnobotany, phytochemistry and pharmacology of Crinum bulbispermum so as to understand its importance and potential in primary healthcare systems. Methods: A review of the literature was undertaken and an in-depth analysis of previous research on ethnobotany, phytochemistry ...

  15. Plant cannabinoids: a neglected pharmacological treasure trove. (United States)

    Mechoulam, Raphael


    Most of the cannabinoids in Cannabis sativa L. have not been fully evaluated for their pharmacological activity. A publication in this issue presents evidence that a plant cannabinoid, Delta(9)-tetrahydrocannabivarin is a potent antagonist of anandamide, a major endogenous cannabinoid. It seems possible that many of the non-psychoactive constituents of this plant will be of biological interest.

  16. Molecular Pharmacology of CXCR4 inhibition

    DEFF Research Database (Denmark)

    Steen, Anne; Rosenkilde, Mette Marie


    pharmacology of well-known CXCR4 antagonists in order to augment the potency and affinity and to increase the specificity of future CXCR4-targeting compounds. In this chapter, binding modes of CXCR4 antagonists that have been shown to mobilize stem cells are discussed. In addition, comparisons between results...

  17. Botany, phytochemistry, pharmacology, and potential application of Polygonum cuspidatum Zucc.: a review. (United States)

    Peng, Wei; Qin, Rongxin; Li, Xiaoli; Zhou, Hong


    chemical constituent or multiple ingredients contributes its pharmacological effects. Additionally, chemicals and their pharmacological effects of the other parts such as the aerial part of this plant should be exploited in order to avoid resource waste and find new chemical constituents. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  18. Pharmacology and function of melatonin receptors

    International Nuclear Information System (INIS)

    Dubocovich, M.L.


    The hormone melatonin is secreted primarily from the pineal gland, with highest levels occurring during the dark period of a circadian cycle. This hormone, through an action in the brain, appears to be involved in the regulation of various neural and endocrine processes that are cued by the daily change in photoperiod. This article reviews the pharmacological characteristics and function of melatonin receptors in the central nervous system, and the role of melatonin in mediating physiological functions in mammals. Melatonin and melatonin agonists, at picomolar concentrations, inhibit the release of dopamine from retina through activation of a site that is pharmacologically different from a serotonin receptor. These inhibitory effects are antagonized by the novel melatonin receptor antagonist luzindole (N-0774), which suggests that melatonin activates a presynaptic melatonin receptor. In chicken and rabbit retina, the pharmacological characteristics of the presynaptic melatonin receptor and the site labeled by 2-[125I]iodomelatonin are identical. It is proposed that 2-[125I]iodomelatonin binding sites (e.g., chicken brain) that possess the pharmacological characteristics of the retinal melatonin receptor site (order of affinities: 2-iodomelatonin greater than 6-chloromelatonin greater than or equal to melatonin greater than or equal to 6,7-di-chloro-2-methylmelatonin greater than 6-hydroxymelatonin greater than or equal to 6-methoxymelatonin greater than N-acetyltryptamine greater than or equal to luzindole greater than N-acetyl-5-hydroxytryptamine greater than 5-methoxytryptamine much greater than 5-hydroxytryptamine) be classified as ML-1 (melatonin 1). The 2-[125I]iodomelatonin binding site of hamster brain membranes possesses different binding and pharmacological characteristics from the retinal melatonin receptor site and should be classified as ML-2. 64 references

  19. Cesarean Sections (United States)

    ... birth after a C-section, called a VBAC ) Emergency C-Sections Some C-sections are unexpected emergency ... side to nurse or using the clutch (or football) hold can take the pressure off your abdomen. ...

  20. A study of needle stick injuries among non-consultant hospital doctors in Ireland.

    LENUS (Irish Health Repository)

    O'Connor, M B


    INTRODUCTION: NCHDs are exposed to a great number of blood-borne infections. Needle stick injuries are possibly the main route of acquiring such infections from a non-consultant hospital doctors (NCHDs) perspective. This study examines NCHDs experiences surrounding needle stick injuries. METHODS: A cross-sectional self-administered anonymous questionnaire survey was conducted on 185 NCHDs working in a clinical setting among seven teaching hospitals in Ireland. Implied consent was obtained. The data was analysed using Excel spreadsheets. Ethical approval was received. RESULTS: A response rate of 85.4% (158\\/185) was achieved. Findings of the study are shown in the manuscript table. CONCLUSIONS: A needle stick injury (NI) history is greater among surgical NCHDs than medical NCHDs. The level of disposable glove usage is worryingly poor. Training in sharps handling and dealing with a NI needs to be addressed. HIV is the blood-borne infection most fear of being contracting as a consequence of a NI.

  1. Angiotensin receptors in Dupuytren's disease: a target for pharmacological treatment? (United States)

    Stephen, Christopher; Touil, Leila; Vaiude, Partha; Singh, Jaipaul; McKirdy, Stuart


    Attempts at the pharmacological treatment of Dupuytren's disease have so far been unsuccessful, and the disease is not yet fully understood on a cellular level. The Renin-Angiotensin System has long been understood to play a circulating hormonal role. However, there is much evidence showing Angiotensin II to play a local role in wound healing and fibrosis, with ACE inhibitors being widely used as an anti-fibrotic agent in renal and cardiac disease. This study was designed to investigate the presence of Angiotensin II receptors 1 (AT1) and 2 (AT2) in Dupuytren's tissue to form a basis for further study into the pharmacological treatment of this condition. Tissue was harvested from 11 patients undergoing surgery for Dupuytren's disease. Each specimen was processed into frozen sections and immunostaining was employed to identify AT1 and AT2 receptors. Immunostaining for AT1 receptors was mildly positive in one patient and negative in all the remaining patients. However, all specimens stained extensively for AT2 receptors. This suggests that the expression of AT2 receptors is more prominent than AT1 receptors in Dupuytren's disease. These findings have opened a new avenue for future research involving ACE inhibitors, AT2 agonists, and AT2 antagonists in Dupuytren's disease.

  2. Hegemonic Shifts: The Latest from the Walls of Northern Ireland

    Directory of Open Access Journals (Sweden)

    Tony Crowley


    Full Text Available This essay considers the changes that have taken place in the murals of Northern Ireland over the past decade or so. It will be argued that although there have been important developments in the murals that reflect the consolidation of ‘peace’ during this period, the walls also tell a different story.  It will be shown that, perhaps predictably, given the paralysis and stagnation that have characterised the power-sharing arrangements, and the disillusionment, cynicism and bitterness towards the political settlement which is now evident, a number of murals offer representations that indicate the growth of tendencies that present latent but real dangers.

  3. The distributional implications of a carbon tax in Ireland

    International Nuclear Information System (INIS)

    Callan, Tim; Lyons, Sean; Scott, Susan; Tol, Richard S.J.; Verde, Stefano


    We study the effects of carbon tax and revenue recycling across the income distribution in the Republic of Ireland. In absolute terms, a carbon tax of EUR20/tCO 2 would cost the poorest households less than EUR3/week and the richest households more than EUR4/week. A carbon tax is regressive, therefore. However, if the tax revenue is used to increase social benefits and tax credits, households across the income distribution can be made better off without exhausting the total carbon tax revenue. (author)

  4. Shiitake Flagellate Dermatitis: the First Case Reported in Ireland

    LENUS (Irish Health Repository)

    Byrne, N


    Shiitake (Lentinula edodes) is the second most commonly consumed mushroom worldwide1. It is used in Asian medicine for its anticarcinogenic, antihypertensive and lipid lowering properties2. Furthermore, extracts of these mushrooms are used in over-the-counter dietary supplements designed to improve the immune system1. The first case of shiitake mushroom induced flagellate dermatitis was described in Japan in 1977 and it is now being reported in the western world3. After literary review and consultation with the Irish National Poisons Information Centre, we believe this is the first reported case of shiitake flagellate dermatitis in Ireland

  5. The epidemiology of rubella in the Republic of Ireland.

    LENUS (Irish Health Repository)

    Jennings, S


    The trend in notified cases of rubella in the Republic of Ireland from 1950 to 1990 has been downward, with a mean interval of four years between peak periods. Vaccine uptake and antenatal immunity levelled out in the 1980s at 85% and 87%, respectively. One hundred and six cases of congenital rubella were recorded between 1975 and 1990, 66 being reported by paediatricians. The fact that cases of congenital rubella still occur highlights the need for a continued and aggressive immunisation policy, up-to-date and cohort-based data on vaccine uptake, and the introduction of a congenital rubella register.

  6. The role of citizen science in monitoring biodiversity in Ireland (United States)

    Donnelly, Alison; Crowe, Olivia; Regan, Eugenie; Begley, Sinead; Caffarra, Amelia


    Citizen science is proving to be an effective tool in tracking the rapid pace at which our environment is changing over large geographic areas. It is becoming increasingly popular, in places such as North America and some European countries, to engage members of the general public and school pupils in the collection of scientific data to support long-term environmental monitoring. Participants in such schemes are generally volunteers and are referred to as citizen scientists. The Christmas bird count in the US is one of the worlds longest running citizen science projects whereby volunteers have been collecting data on birds on a specific day since 1900. Similar volunteer networks in Ireland have been in existence since the 1960s and were established to monitor the number and diversity of birds throughout the country. More recently, initiatives such as Greenwave (2006) and Nature Watch (2009) invite school children and members of the general public respectively, to record phenology data from a range of common species of plant, insect and bird. In addition, the Irish butterfly and bumblebee monitoring schemes engage volunteers to record data on sightings of these species. The primary purpose of all of these networks is to collect data by which to monitor changes in wildlife development and diversity, and in the case of Greenwave to involve children in hands-on, inquiry-based science. Together these various networks help raise awareness of key environmental issues, such as climate change and loss of biodiversity, while at the same time promote development of scientific skills among the general population. In addition, they provide valuable scientific data by which to track environmental change. Here we examine the role of citizen science in monitoring biodiversity in Ireland and conclude that some of the data collected in these networks can be used to fulfil Ireland's statutory obligations for nature conservation. In addition, a bee thought previously to be extinct

  7. Pharmacists' and general practitioners' pharmacology knowledge and pharmacotherapy skills

    NARCIS (Netherlands)

    Keijsers, Carolina J P W; Leendertse, Anne J; Faber, Adrianne; Brouwers, Jacobus R B J; de Wildt, Dick J; Jansen, Paul A F

    Understanding differences in the pharmacology knowledge and pharmacotherapy skills of pharmacists and physicians is vital to optimizing interprofessional collaboration and education. This study investigated these differences and the potential influence of work experience. The pharmacology knowledge

  8. Schools as institutions for peace in Northern Ireland: pupils’, parents’ and teachers’ perspectives on the community relations dimension

    Directory of Open Access Journals (Sweden)

    Ron Smith


    Full Text Available Abstract: The aim of the research reported in this paper is to inform the processes of school improvement for better intercommunal relations in Northern Ireland. Notwithstanding the present peace process, the quality of community relations remains a crucial concern for those interested in long-term stability. The research strategy drew on data from nine case study schools and was considered to be part of an interpretist-constructivist paradigm involving an inductive or grounded theory approach to analysis. The views of pupils, parents and teachers on the contribution of schooling towards improved inter-group relationships were explored in some depth and the wealth of rich data shed light on school practices and key institutional factors implicated in effectiveness and improvement. Nineteen themes were identified which appeared not to be discrete or self-contained but interact in complex ways creating different patterns at different organisational sites. Furthermore, the patterns spun by these factors appeared to vary in nature through relationship with identities such as geographical location, socio-economic status, ethnicity and gender. It is argued that this study contributes towards the existing literatures on school effectiveness and improvement and schooling and sectarianism in Northern Ireland. The results suggested that education for community relations in N. Ireland required an alternative concept of school effectiveness to the received model. The emerging organisational picture was more consistent with sensitivity to context models of effectiveness and improvement. The analysis in the final section was designed to offer some broad pointers for school improvement.

  9. Pharmacologic Treatments for Binge-Eating Disorder. (United States)

    McElroy, Susan L


    Binge-eating disorder (BED) is the most common eating disorder and is associated with poor physical and mental health outcomes. Psychological and behavioral interventions have been a mainstay of treatment for BED, but as understanding of this disorder has grown, pharmacologic agents have become promising treatment options for some patients. At this time, only one drug-the stimulant prodrug lisdexamfetamine-is approved for the treatment of BED. Numerous classes of medications including antidepressants, anticonvulsants, and antiobesity drugs have been explored as off-label treatments for BED with variable success. Although not all patients with BED may be suitable candidates for pharmacotherapy, all patients should be considered for and educated about pharmacologic treatment options. © Copyright 2017 Physicians Postgraduate Press, Inc.

  10. Pharmacology profiling of chemicals and proteins

    DEFF Research Database (Denmark)

    Kringelum, Jens Vindahl

    between pharmaceuticals and proteins in vivo potential leads to unwanted adverse effects, toxicity and reduced half-life, but can also lead to novel therapeutic effects of already approved pharmaceuticals. Hence identification of in vivo targets is of importance in discovery, development and repurposing....... This limitation complicates adverse effect assessment in the early drug-development phase, thus contributing to drugattrition. Prediction models offer the possibility to close these gaps and provide more complete pharmacology profiles, however improvements in performances are required for these tools to serve...... to its nonself origin, which potentially alters the pharmacology profile of the substance. The neutralization of biopharmaceuticals by antidrug antibodies (ADAs) is an important element in the immune response cascade, however studies of ADA binding site on biopharmaceuticals, referred to as B...

  11. Common mullein, pharmacological and chemical aspects

    Directory of Open Access Journals (Sweden)

    Muhammad Riaz

    Full Text Available Verbascum thapsus L. [Khardhag or Common mullein], a member of the family Scrophulariaceae, is a famous herb that is found all over Europe, in temperate Asia, in North America and is well-reputed due to its medicinal properties. This medicinal herb contains various chemical constituents like saponins, iridoid and phenylethanoid glycosides, flavonoids, vitamin C and minerals. It is famous in various communities worldwide for the treatment of various disorders of both humans and animals aliments. A number of pharmacological activities such as anti-inflammatory, antioxidant, anticancer, antimicrobial, antiviral, antihepatotoxic and anti-hyperlipidemic activity have been ascribed to this plant. The plant is used to treat tuberculosis also, earache and bronchitis. In the present paper botanical and ethnomedicinal description, pharmacological profile and phytochemistry of this herb is being discussed.

  12. Pharmacologic management of chronic neuropathic pain (United States)

    Mu, Alex; Weinberg, Erica; Moulin, Dwight E.; Clarke, Hance


    Abstract Objective To provide family physicians with a practical clinical summary of the Canadian Pain Society (CPS) revised consensus statement on the pharmacologic management of neuropathic pain. Quality of evidence A multidisciplinary interest group within the CPS conducted a systematic review of the literature on the current treatments of neuropathic pain in drafting the revised consensus statement. Main message Gabapentinoids, tricyclic antidepressants, and serotonin-norepinephrine reuptake inhibitors are the first-line agents for treating neuropathic pain. Tramadol and other opioids are recommended as second-line agents, while cannabinoids are newly recommended as third-line agents. Other anticonvulsants, methadone, tapentadol, topical lidocaine, and botulinum toxin are recommended as fourth-line agents. Conclusion Many pharmacologic analgesics exist for the treatment of neuropathic pain. Through evidence-based recommendations, the CPS revised consensus statement helps guide family physicians in the management of patients with neuropathic pain. PMID:29138154

  13. Pharmacological evaluation of bee venom and melittin

    Directory of Open Access Journals (Sweden)

    Camila G. Dantas

    Full Text Available The objective of this study was to identify the pharmacological effects of bee venom and its major component, melittin, on the nervous system of mice. For the pharmacological analysis, mice were treated once with saline, 0.1 or 1.2 mg/kg of bee venom and 0.1 mg/kg of melittin, subcutaneously, 30 min before being submitted to behavioral tests: locomotor activity and grooming (open-field, catalepsy, anxiety (elevated plus-maze, depression (forced swimming test and apomorphine-induced stereotypy. Haloperidol, imipramine and diazepam were administered alone (positive control or as a pre-treatment (haloperidol.The bee venom reduced motor activity and promoted cataleptic effect, in a similar manner to haloperidol.These effects were decreased by the pretreatment with haloperidol. Both melittin and bee venom decreased the apomorphine-induced stereotypies. The data indicated the antipsychotic activity of bee venom and melittin in a murine model.

  14. A national survey (NAP5-Ireland baseline) to estimate an annual incidence of accidental awareness during general anaesthesia in Ireland.

    LENUS (Irish Health Repository)

    Jonker, W R


    As part of the 5th National Audit Project of the Royal College of Anaesthetists and the Association of Anaesthetists of Great Britain and Ireland concerning accidental awareness during general anaesthesia, we issued a questionnaire to every consultant anaesthetist in each of 46 public hospitals in Ireland, represented by 41 local co-ordinators. The survey ascertained the number of new cases of accidental awareness becoming known to them for patients under their care or supervision for a calendar year, as well as their career experience. Consultants from all hospitals responded, with an individual response rate of 87% (299 anaesthetists). There were eight new cases of accidental awareness that became known to consultants in 2011; an estimated incidence of 1:23 366. Two out of the eight cases (25%) occurred at or after induction of anaesthesia, but before surgery; four cases (50%) occurred during surgery; and two cases (25%) occurred after surgery was complete, but before full emergence. Four cases were associated with pain or distress (50%), one after an experience at induction and three after experiences during surgery. There were no formal complaints or legal actions that arose in 2011 related to awareness. Depth of anaesthesia monitoring was reported to be available in 33 (80%) departments, and was used by 184 consultants (62%), 18 (6%) routinely. None of the 46 hospitals had a policy to prevent or manage awareness. Similar to the results of a larger survey in the UK, the disparity between the incidence of awareness as known to anaesthetists and that reported in trials warrants explanation. Compared with UK practice, there appears to be greater use of depth of anaesthesia monitoring in Ireland, although this is still infrequent.

  15. Local Anesthetics: Review of Pharmacological Considerations (United States)

    Becker, Daniel E; Reed, Kenneth L


    Local anesthetics have an impressive history of efficacy and safety in medical and dental practice. Their use is so routine, and adverse effects are so infrequent, that providers may understandably overlook many of their pharmacotherapeutic principles. The purpose of this continuing education article is to provide a review and update of essential pharmacology for the various local anesthetic formulations in current use. Technical considerations will be addressed in a subsequent article. PMID:22822998

  16. Conception of pharmacological knowledge and needs amongst ...

    African Journals Online (AJOL)

    Students who are taking/have taken the medical pharmacology course completed an 18-question survey within 10min by marking one/more choices from ... and 31.1% different drugs in a group; 45.8% prefer to study lecturers' notes, 26.7% textbooks, 9.8% the Internet, and 2.7% journals; 46.7% use standard textbooks, ...

  17. Electronic cigarettes and nicotine clinical pharmacology


    Schroeder, Megan J; Hoffman, Allison C


    Objective To review the available literature evaluating electronic cigarette (e-cigarette) nicotine clinical pharmacology in order to understand the potential impact of e-cigarettes on individual users, nicotine dependence and public health. Methods Literature searches were conducted between 1 October 2012 and 30 September 2013 using key terms in five electronic databases. Studies were included in the review if they were in English and publicly available; non-clinical studies, conference abst...

  18. Pharmacological interventions to treat phlebitis: systematic review. (United States)

    dos Reis, Paula Elaine Diniz; Silveira, Renata Cristina de Campos Pereira; Vasques, Christiane Inocêncio; de Carvalho, Emilia Campos


    This study presents a systematic review for evaluating effective pharmacological actions for the treatment of phlebitis stemming from infusion therapy. The studies reviewed were categorized according to the type of therapeutic approach proposed by the author and by the level of evidence presented. The review found that topical nitroglycerin and notoginseny were more effective in the reduction of the inflammatory process when compared with other proposed alternatives. Nevertheless, the development of research related to possible alternatives for the treatment of phlebitis is important.

  19. Pharmacological Aspects of Neuro-Immune Interactions. (United States)

    Tarasov, Vadim V; Kudryashov, Nikita V; Chubarev, Vladimir N; Kalinina, Tatiana S; Barreto, George E; Ashraf, Ghulam Md; Aliev, Gjumrakch


    The use of systematic approach for the analysis of mechanism of action of drugs at different levels of biological organization of organisms is an important task in experimental and clinical pharmacology for drug designing and increasing the efficacy and safety of drugs. The analysis of published data on pharmacological effects of psychotropic drugs possessing immunomodulatory and/or antiviral properties have shown a correlation between central effects of examined drugs associated with the impact on the processes of neurogenesis of adult brain and survival of neurons, and their ability to alter levels of key proinflammatory cytokines. The changes that occur as a result of the influence of pharmacological agents at one of the systems should inevitably lead to the functional reorganization at another. Integrative mechanisms underlying the neuro-immune interactions may explain the "pleiotropic" pharmacological effects of some antiviral and immunomodulatory drugs. Amantadine, which was originally considered as an antiviral agent, was approved as anti-parkinsonic drug after its wide medical use. The prolonged administration of interferon alpha caused depression in 30-45% of patients, thus limiting its clinical use. The antiviral drug "Oseltamivir" may provoke the development of central side effects, including abnormal behavior, delirium, impaired perception and suicides. Anti-herpethetical drug "Panavir" shows pronounced neuroprotective properties. The purpose of this review is to analyze the experimental and clinical data related to central effects of drugs with antiviral or/and immunotropic activity, and to discover the relationship of these effects with changes in reactivity of immune system and proinflammatory response. Copyright© Bentham Science Publishers; For any queries, please email at

  20. Ireland and Spain 1931-1933. Divergent Republics

    Directory of Open Access Journals (Sweden)

    Alvaro Jaspe


    Full Text Available This paper will examine the development of the fledgling diplomatic ties between the new Irish state and the recently established Spanish legation based in Dublin.  It will analyse the formal establishment of political, cultural and social links developed in contemporary times between the two old historical allies that had previously been limited to polite lip-service; conditioned, in part, as they were by  monarchical Madrid’s caution in regard to London and previous Spanish reluctance to engage with a rebellious state.  1931 signified a volte face in the relationship developing between Dublin and Madrid since the establishment of a Spanish consulate in Dublin in March 1924, facilitated by their commitment to the League of Nations, to which both were strongly committed in the 1920s.  This paper will illustrate how the declaration of the II Republic in Spain was a crossroads in the relationship between these two nations.  The roles of ‘rebel’ and ‘traditionalist’ state had been instantly switched.  The Church and much of the new political elite in Ireland viewed republican reforms in Spain with ever growing and public distaste creating conflict among Irish republicanism, post-independence.  The main Spanish republican representative in Ireland in this 1931-33 period, Emilio Sanz y Tovar, became very sensitive to these schisms as he tried to cement political and socio-economic ties with his Irish hosts.

  1. Environmental tax reform: an assessment of social responses in Ireland

    International Nuclear Information System (INIS)

    Clinch, J. Peter; Dunne, Louise


    Environmental tax reform (ETR) is widely accepted to be a policy with desirable environmental, and other economic effects. The question arises then as to why its implementation has been so patchy. There is a broad literature on the economic impact of ETR, however, there have been very few research efforts devoted to understanding the roles and imperatives of the public, policy makers, businesses and other stakeholders who are addressed by ETR. This paper examines the impediments to ETR in Ireland. Focus groups were formed comprising of members of the general public and these provided a forum for detailed reactions to the ETR concept. Interviews were conducted with policy makers and key business people in an attempt to identify both the patterns of thinking behind ETR and the main obstacles to its introduction. Having presented the results, a theory of the main impediments to ETR is developed. The opinions of the members of the public, the business community and the policy makers highlight a number of issues that need to be addressed in the future design of ETR in Ireland. The principal potential impediments to ETR include: mistrust of the government, implausibility of the policy, means of hypothecation, information asymmetries, the political system, the structure of government, the macroeconomic environment, the impact on competitiveness, inequity between sectors, regressivity, elasticities and the level of the tax, terminology, and the marketing of ETR

  2. Burning peat in Ireland: An electricity market dispatch perspective

    International Nuclear Information System (INIS)

    Tuohy, Aidan; Bazilian, Morgan; Doherty, Ronan; Gallachoir, Brian O; O'Malley, Mark


    This paper examines peat power production in Ireland under the three pillars of energy policy-security, competitiveness and environment. Peat contributes to energy security-as an indigenous fuel, it reduces dependency on imports. During a period of low capacity margins, the operation of the peat plants is useful from a system security perspective. Peat generation is being financially supported by consumers through an electricity levy. The fuel also has high carbon intensity. It is not politically viable to consider peat on equal economic criteria to other plant types because of history and location. This paper reviews electricity generation through combustion of peat in Ireland, and quantifies the costs of supporting peat utilising economic dispatch tools, finding the subsidy is not insignificant from a cost or carbon perspective. It shows that while peat is beneficial for one pillar of energy policy (security), the current usage of peat is not optimal from a competitiveness or environmental perspective. By switching from the current 'must-run' mode of operation for peat to the 'dispatched' mode used for the other generation, significant societal savings (in the range Euro 21 m per annum) can be achieved, as well as reducing system emissions by approximately 5% per year.

  3. Environmental tax reform: an assessment of social responses in Ireland

    Energy Technology Data Exchange (ETDEWEB)

    Clinch, J. Peter; Dunne, Louise [Department of Environmental Studies/Urban Institute of Ireland, University College Dublin, Richview, Clonskeagh, Dublin 14 (Ireland)


    Environmental tax reform (ETR) is widely accepted to be a policy with desirable environmental, and other economic effects. The question arises then as to why its implementation has been so patchy. There is a broad literature on the economic impact of ETR, however, there have been very few research efforts devoted to understanding the roles and imperatives of the public, policy makers, businesses and other stakeholders who are addressed by ETR. This paper examines the impediments to ETR in Ireland. Focus groups were formed comprising of members of the general public and these provided a forum for detailed reactions to the ETR concept. Interviews were conducted with policy makers and key business people in an attempt to identify both the patterns of thinking behind ETR and the main obstacles to its introduction. Having presented the results, a theory of the main impediments to ETR is developed. The opinions of the members of the public, the business community and the policy makers highlight a number of issues that need to be addressed in the future design of ETR in Ireland. The principal potential impediments to ETR include: mistrust of the government, implausibility of the policy, means of hypothecation, information asymmetries, the political system, the structure of government, the macroeconomic environment, the impact on competitiveness, inequity between sectors, regressivity, elasticities and the level of the tax, terminology, and the marketing of ETR. (author)

  4. Nazis on the State Payroll in 1930s Ireland

    Directory of Open Access Journals (Sweden)

    David O’Donoghue


    Full Text Available The Austro-German population of Ireland in 1936 was 529. Approximately 25% of the adult male cohort were, or became, members of Hitler’s Nazi Party (NSDAP. A small cadre of senior figures in the party were active in recruiting new members as Nazi Germany’s fortunes rose from 1933 to 1939. Some 32 Germans and Austrians resident in pre-war Ireland have been identified as Nazi Party members, although a small number of these were exchange students rather than full-time residents. This paper examines the six NSDAP members who held senior positions in the Irish public service. As Irish state employees they were in a contradictory position: swearing loyalty to Adolf Hitler’s Third Reich while attempting to hold down important jobs on the Irish state payroll. Dr. David O’Donoghue’s article scrutinises the activities of these six men, as well as explaining how they tried, by varying degrees, to serve two masters. The paper also examines their wartime and post-war lives.

  5. Women's right to health and Ireland's abortion laws. (United States)

    Taylor, Maeve


    The provision of the Irish Constitution that guarantees "the unborn" a right to life equal to that of a pregnant woman has consequences for access to abortion and the care of women in pregnancy generally. Long-awaited legislation to give effect to the narrow constitutional right to abortion was enacted into law in 2013. In 2014, a guidance document for health professionals' implementation of the legislation was published. However, the legislation and guidance document fall far short of international human rights bodies' recommendations: they fail to deliver effective procedural rights to all of the women eligible for lawful abortion within the state and create new legal barriers to women's reproductive rights. At the same time, cases continue to highlight that the Irish Constitution imposes an unethical and rights-violating legal regime in non-abortion-related contexts. Recent developments suggest that both the failure to put guidelines in place and the development of guidelines that are not centered on women or based on rights further reduce women's access to rights and set unacceptable limitations on women's reproductive autonomy. Nevertheless, public and parliamentary scrutiny of cases involving Ireland's abortion laws is increasingly focusing on the need for reform. Copyright © 2015 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

  6. Modelling future private car energy demand in Ireland

    International Nuclear Information System (INIS)

    Daly, Hannah E.; Ó Gallachóir, Brian P.


    Targeted measures influencing vehicle technology are increasingly a tool of energy policy makers within the EU as a means of meeting energy efficiency, renewable energy, climate change and energy security goals. This paper develops the modelling capacity for analysing and evaluating such legislation, with a focus on private car energy demand. We populate a baseline car stock and car activity model for Ireland to 2025 using historical car stock data. The model takes account of the lifetime survival profile of different car types, the trends in vehicle activity over the fleet and the fuel price and income elasticities of new car sales and total fleet activity. The impacts of many policy alternatives may only be simulated by such a bottom-up approach, which can aid policy development and evaluation. The level of detail achieved provides specific insights into the technological drivers of energy consumption, thus aiding planning for meeting climate targets. This paper focuses on the methodology and baseline scenario. Baseline results for Ireland forecast a decline in private car energy demand growth (0.2%, compared with 4% in the period 2000–2008), caused by the relative growth in fleet efficiency compared with activity. - Highlights: ► Bottom-up private car energy forecasting model developed. ► The demographic and technological distribution of vehicle activity is a key veriable. ► Irish car energy demand growth predicted to slow steadily. ► Change in vehicle taxation forecast to save 10% energy.

  7. Activities of Intellectual Disability Clinical Nurse Specialists in Ireland. (United States)

    Doody, Owen; Slevin, Eamonn; Taggart, Laurence

    The aim of this study was to identify the contribution of Irish intellectual disability clinical nurse specialists (ID CNSs) to service delivery. A nonexperimental descriptive design was selected to survey ID CNSs presently working in Ireland. The questionnaire was developed based on focus group interviews, available literature, and expert panel views. Ethical approval and access were granted to all ID CNSs in Ireland. Thirty-two responded (33.68% response rate) from all work areas (voluntary organizations or health service executive) practicing within residential, community, or school services. Respondents were surveyed across a range of areas (demographic details and support to client, staff, family, organization, community, other agencies, and professional development). Findings identify that ID CNSs are active in all aspects of their roles as clinical specialist, educator, communicator, researcher, change agent, and leader, thus supporting person-centered care and improving service delivery. To meet changing healthcare demands, promote person-centered care, and improve service delivery, the CNS role in ID should be developed and supported. The findings merit a further study on ID CNS role activity, possible variables influencing role activity, and team members' views.

  8. Krypton-85 and other airborne radioactivity measurements throughout Ireland

    International Nuclear Information System (INIS)

    Smith, K.J.; Murray, M.; Wong, J.; Sequeira, S.; Long, S.C.; Rafferty, B.


    In compliance with articles 35 and 36 of the EURATOM Treaty, the Radiological Protection Institute of Ireland (RPII) undertakes a comprehensive programme of radioactivity monitoring in the Irish terrestrial environment. Radioactivity is present in the terrestrial environment due to natural processes, the testing of nuclear weapons in the atmosphere, accidents such as the Chernobyl accident and the routine discharge of radionuclides from nuclear installations. The RPII monitors airborne radioactivity concentrations at ten stations throughout Ireland, of which, nine are equipped with low volume particulate samplers and one, in Dublin, with a high volume particulate sampler. The low volume particulate samples are assessed for total beta activity and high volume samples for gamma emitting radionuclides such as caesium-137 and beryllium-7. In addition, air sampled at the RPII laboratory in Dublin, is monitored for krypton-85, a radioactive noble gas, released into the environment primarily as a result of the reprocessing of nuclear fuel at installations such as Sellafield in the UK and La Hague in France. Since the inception of the krypton measurements in 1993 a trend of increasing atmospheric concentrations has been observed. The results of the krypton-85 monitoring, as well as the airborne radioactivity concentration measurements, will be presented and discussed in this paper. (author)


    de Londras, Fiona


    Under the Irish Constitution abortion is allowed only where the life of the pregnant woman is at risk. The provision in question, Article 40.3.3 (or the 8th Amendment) has long been criticised for failing to respect women's autonomy, and in Mellet v Ireland, the UN Human Rights Committee found that Amanda Jane Mellet, who travelled to Liverpool to access abortion following a finding that her foetus suffered a fatal abnormality, had suffered a violation of her rights under the International Covenant on Civil and Political Rights (ICCPR). In this commentary I demonstrate the value of Mellet when compared to the possible legal findings in such circumstances under both the Constitution and the European Convention on Human Rights, and argue that the findings are not restricted to cases of fatal foetal abnormality. Rather, the Committee's decision illustrates the suffering that all women in Ireland who travel to access abortion experience, arguably constituting a violation of their right to be free from cruel, inhuman, and degrading treatment. On that reading, Mellet signifies the need to implement a comprehensive rethink of Irish abortion law including, but going beyond, access to abortion in cases of fatal foetal abnormality. © The Author 2016. Published by Oxford University Press; all rights reserved. For Permissions, please email:

  10. Frequency and consequences of violence in community pharmacies in Ireland.

    LENUS (Irish Health Repository)

    Fitzgerald, D


    BackgroundViolence in community pharmacies in Ireland is thought to be common but underreported. The frequency and consequences of violence has not been studied previously.AimsTo establish the frequency and nature of violence in community pharmacies over 12 months, and to investigate the impact of violence on employees and possible consequence for the industry.MethodsA two-part survey was distributed to community pharmacies in Ireland in 2011 (n = 200). The first part related to pharmacy demographics, the frequency of various violent events (verbal abuse, threats etc.), the respondents\\' worry regarding violence and its impact on their co-workers. The second part concerned individual employees\\' subjective response to a violent event, using the Impact of Event Scale-Revised (IES-R).ResultsFifty-seven per cent of the pharmacies responded, with 77% reporting some violent event (verbal or physical), over the past year. Eighteen per cent reported physical assault, and 63% were worried about workplace violence. There was no association between late night opening hours or pharmacy size and violence frequency. Positive statistically significant correlations were present between all types of violence and absenteeism and employee fear levels. An IES-R score could be calculated for 75 respondents; the median IES-R score was 8 with 19% reporting clinically significant scores.ConclusionsViolence is common in Irish community pharmacies and impacts on employees and the industry.

  11. Molecular epidemiology of Mycobacterium tuberculosis clinical isolates in Southwest Ireland.

    LENUS (Irish Health Repository)

    Ojo, Olabisi O


    Tuberculosis has had significant effects on Ireland over the past two centuries, causing persistently higher morbidity and mortality than in neighbouring countries until the last decade. This study describes the results of genotyping and drug susceptibility testing of 171 strains of Mycobacterium tuberculosis complex isolated between January 2004 and December 2006 in a region of Ireland centred on the city of Cork. Spoligotype comparisons were made with the SpolDB4 database and clustered 130 strains in 23 groups, forty-one strains showed unique Spoligotyping patterns. The commonest spoligotypes detected were ST0137 (X2) (16.9%), and ST0351 (15.8%) (\\'U\\' clade). The major spoligotype clades were X (26.2%), U (19.3%), T (15.2%), Beijing (5.9%), Haarlem (4.7%), LAM (4.1%), BOVIS (1.75%), with 12.9% unassigned strains. A 24-locus VNTR genotyping produced 15 clusters containing 49 isolates, with high discrimination index (HGDI>0.99). A combination of Spoligotyping and VNTR reduced the number of clustered isolates to 47 in 15 clusters (27.5%). This study identified ST351 as common among Irish nationals, and found a low rate of drug resistance with little evidence of transmission of drug resistant strains. Strain clustering was significantly associated with age under 55 years and Irish nationality. Only strains of Euro-American lineage formed clusters. Molecular typing did not completely coincide with the results of contact investigations.

  12. vCJD risk in the Republic of Ireland.

    LENUS (Irish Health Repository)

    Harney, Michael S


    BACKGROUND: The Republic of Ireland has the second highest incidence of BSE worldwide. Only a single case of vCJD has been identified to date. METHODS: We estimate the total future number of clinical cases of vCJD using an established mathematical model, and based on infectivity of bovine tissue calculated from UK data and on the relative exposure to BSE contaminated meat. RESULTS: We estimate 1 future clinical case (95% CI 0-15) of vCJD in the Republic of Ireland. Irish exposure is from BSE infected indigenous beef products and from imported UK beef products. Additionally, 2.5% of the Irish population was exposed to UK beef through residing in the UK during the \\'at-risk\\' period. The relative proportion of risk attributable to each of these three exposures individually is 2:2:1 respectively. CONCLUSIONS: The low numbers of future vCJD cases estimated in this study is reassuring for the Irish population and for other countries with a similar level of BSE exposure.

  13. Pharmacological Effects of Biotin in Animals. (United States)

    Riveron-Negrete, Leticia; Fernandez-Mejia, Cristina


    In recent decades, it was found that vitamins affect biological functions in ways other than their long-known functions; niacin is the best example of a water-soluble vitamin known to possess multiple actions. Biotin, also known as vitamin B7 or vitamin H, is a water-soluble B-complex vitamin that serves as a covalently-bound coenzyme of carboxylases. It is now well documented that biotin has actions other than participating in classical enzyme catalysis reactions. Several lines of evidence have demonstrated that pharmacological concentrations of biotin affect glucose and lipid metabolism, hypertension, reproduction, development, and immunity. The effect of biotin on these functions is related to its actions at the transcriptional, translational, and post-translational levels. The bestsupported mechanism involved in the genetic effects of biotin is the soluble guanylate cyclase/protein kinase G (PKG) signaling cascade. Although there are commercially-available products containing pharmacological concentrations of biotin, the toxic effects of biotin have been poorly studied. This review summarizes the known actions and molecular mechanisms of pharmacological doses of biotin in animals and current information regarding biotin toxicity. Copyright© Bentham Science Publishers; For any queries, please email at

  14. Phage Therapy: Eco-Physiological Pharmacology

    Directory of Open Access Journals (Sweden)

    Stephen T. Abedon


    Full Text Available Bacterial virus use as antibacterial agents, in the guise of what is commonly known as phage therapy, is an inherently physiological, ecological, and also pharmacological process. Physiologically we can consider metabolic properties of phage infections of bacteria and variation in those properties as a function of preexisting bacterial states. In addition, there are patient responses to pathogenesis, patient responses to phage infections of pathogens, and also patient responses to phage virions alone. Ecologically, we can consider phage propagation, densities, distribution (within bodies, impact on body-associated microbiota (as ecological communities, and modification of the functioning of body “ecosystems” more generally. These ecological and physiological components in many ways represent different perspectives on otherwise equivalent phenomena. Comparable to drugs, one also can view phages during phage therapy in pharmacological terms. The relatively unique status of phages within the context of phage therapy as essentially replicating antimicrobials can therefore result in a confluence of perspectives, many of which can be useful towards gaining a better mechanistic appreciation of phage therapy, as I consider here. Pharmacology more generally may be viewed as a discipline that lies at an interface between organism-associated phenomena, as considered by physiology, and environmental interactions as considered by ecology.

  15. Pharmacological enhancement of treatment for amblyopia

    Directory of Open Access Journals (Sweden)

    Rashad MA


    Full Text Available Mohammad A RashadOphthalmology Department, Faculty of Medicine, Ain Shams University, Cairo, EgyptBackground: The purpose of this study was to compare a weight-adjusted dose of carbidopa-levodopa as treatment adjunctive to occlusion therapy with occlusion therapy alone in children and adults with different types of amblyopia.Methods: This prospective study included 63 patients with amblyopia classified into two groups, ie, an occlusion group which included 35 patients who received occlusion therapy only and a pharmacological enhancement group which included 28 patients who received oral carbidopa-levodopa together with occlusion therapy for 6 weeks.Results: The mean logarithm of the minimal angle of resolution (logMAR of the eyes with amblyopia was not significantly different in the occlusion group (0.52, 0.52, and 0.51 than in the pharmacological enhancement group (0.58, 0.49, and 0.56 at three follow-up visits (at months 1, 3, and 12, respectively. There was a highly significant improvement in mean logMAR of amblyopic eyes compared with baseline in both occlusion groups (from 0.68 to 0.52, from 0.68 to 0.52, and from 0.68 to 0.51 and in the pharmacological enhancement group (from 0.81 to 0.58, from 0.81 to 0.49, and from 0.81 to 0.56 at the month 1, 3, and 12 visits (P = 0.01, P = 0.01, and P = 0.001, respectively. The improvement of mean logMAR in the subgroup of patients older than 12 years was greater in the pharmacological enhancement group (42.5% than in the occlusion group (30%. The improvement of mean logMAR in the subgroup of patients with severe amblyopia was greater in the pharmacological enhancement group (34.3% than in the occlusion group (22%.Conclusion: Significant improvement was reported in both groups at all follow-up visits over 1 year. Regardless of the etiology of amblyopia, levodopa-carbidopa may be added to part-time occlusion in older patients as a means of increasing the plasticity of the visual cortex. Levodopa may add

  16. Pharmacological enhancement of treatment for amblyopia (United States)

    Rashad, Mohammad A


    Background The purpose of this study was to compare a weight-adjusted dose of carbidopa- levodopa as treatment adjunctive to occlusion therapy with occlusion therapy alone in children and adults with different types of amblyopia. Methods This prospective study included 63 patients with amblyopia classified into two groups, ie, an occlusion group which included 35 patients who received occlusion therapy only and a pharmacological enhancement group which included 28 patients who received oral carbidopa-levodopa together with occlusion therapy for 6 weeks. Results The mean logarithm of the minimal angle of resolution (logMAR) of the eyes with amblyopia was not significantly different in the occlusion group (0.52, 0.52, and 0.51) than in the pharmacological enhancement group (0.58, 0.49, and 0.56) at three follow-up visits (at months 1, 3, and 12, respectively). There was a highly significant improvement in mean logMAR of amblyopic eyes compared with baseline in both occlusion groups (from 0.68 to 0.52, from 0.68 to 0.52, and from 0.68 to 0.51) and in the pharmacological enhancement group (from 0.81 to 0.58, from 0.81 to 0.49, and from 0.81 to 0.56) at the month 1, 3, and 12 visits (P = 0.01, P = 0.01, and P = 0.001, respectively). The improvement of mean logMAR in the subgroup of patients older than 12 years was greater in the pharmacological enhancement group (42.5%) than in the occlusion group (30%). The improvement of mean logMAR in the subgroup of patients with severe amblyopia was greater in the pharmacological enhancement group (34.3%) than in the occlusion group (22%). Conclusion Significant improvement was reported in both groups at all follow-up visits over 1 year. Regardless of the etiology of amblyopia, levodopa-carbidopa may be added to part-time occlusion in older patients as a means of increasing the plasticity of the visual cortex. Levodopa may add to the effect of occlusion in severe amblyopia and bilateral amblyopia. PMID:22536029

  17. Traditional uses, phytochemistry and pharmacology of wild banana (Musa acuminata Colla): A review. (United States)

    Mathew, Nimisha Sarah; Negi, Pradeep Singh


    role of M. acuminata plant parts used by various tribes and ethnic groups across the geographical areas of the world. This review presents information on phytochemicals and pharmacological activities of M. acuminata plant parts. Pharmacological studies support the traditional uses of the plant, and probably validate the uses of M. acuminata by the indigenous people to treat and heal many infections and diseases. Some studies on animal models have been carried out, which also provide evidence of efficacy of the M. acuminata plant as a therapeutic agent. These observations suggest that M. acuminata plant parts possesses pluripharmacological properties, and can be used in designing potent therapeutic agents. However, individual bioactive constituent(s) from different parts of this plant need further investigations to confirm various pharmacological claims, and to explore the potential of M. acuminata in the development of drugs and use in functional foods. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  18. Traditional uses, phytochemistry, and pharmacology of the genus Acer (maple): A review. (United States)

    Bi, Wu; Gao, Ying; Shen, Jie; He, Chunnian; Liu, Haibo; Peng, Yong; Zhang, Chunhong; Xiao, Peigen


    the major safety concern of these plants is in the veterinary field. Based on our systematic review, Acer species can be used to treat rheumatism, hepatic disorders, eye disease, pain, etc. effectively. Some indications from ethnomedicine have been validated by pharmacological activities, such as the anti-inflammatory and hepatoprotective activities of the species. The available literature showed that most of the activities of these species can be attributed to flavonoids and tannins. To ensure the safety and efficacy in clinical practice in the future, studies identifying active molecules and clarifying their pharmacological mechanisms as well as toxicity are needed. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  19. Predictors of adherence to pharmacological and behavioral treatment in a cessation trial among smokers in Aleppo, Syria. (United States)

    Ben Taleb, Ziyad; Ward, Kenneth D; Asfar, Taghrid; Bahelah, Raed; Maziak, Wasim


    The development of evidence-based smoking cessation programs is in its infancy in developing countries, which continue to bear the main brunt of the tobacco epidemic. Adherence to treatment recommendations is an important determinant of the success of smoking cessation programs, but little is known about factors influencing adherence to either pharmacological or behavioral treatment in developing countries settings. Our study represents the first attempt to examine the predictors of adherence to cessation treatment in a low-income developing country. Predictors of adherence to pharmacological and behavioral treatment were identified by analyzing data from a multi-site, two-group, parallel-arm, double-blind, randomized, placebo-controlled smoking cessation trial in primary care clinics in Aleppo, Syria. Participants received 3 in-person behavioral counseling sessions plus 5 brief follow-up phone counseling sessions, and were randomized to either 6 weeks of nicotine or placebo patch. Of the 269 participants, 68% adhered to pharmacological treatment, while 70% adhered to behavioral counseling. In logistic regression modeling, lower adherence to pharmacological and behavioral treatment was associated with higher daily smoking at baseline, greater withdrawal symptoms, and perception of receiving placebo instead of active nicotine patch. Women showed lower adherence than men to behavioral treatment, while being assigned to placebo condition and baseline waterpipe use were associated with lower adherence to pharmacological treatment. Adherence to cessation treatment for cigarette smokers in low-income countries such as Syria may benefit from integrated cessation components that provide intensive treatment for subjects with higher nicotine dependence, and address concurrent waterpipe use at all stages. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  20. Process Pharmacology: A Pharmacological Data Science Approach to Drug Development and Therapy. (United States)

    Lötsch, Jörn; Ultsch, Alfred


    A novel functional-genomics based concept of pharmacology that uses artificial intelligence techniques for mining and knowledge discovery in "big data" providing comprehensive information about the drugs' targets and their functional genomics is proposed. In "process pharmacology", drugs are associated with biological processes. This puts the disease, regarded as alterations in the activity in one or several cellular processes, in the focus of drug therapy. In this setting, the molecular drug targets are merely intermediates. The identification of drugs for therapeutic or repurposing is based on similarities in the high-dimensional space of the biological processes that a drug influences. Applying this principle to data associated with lymphoblastic leukemia identified a short list of candidate drugs, including one that was recently proposed as novel rescue medication for lymphocytic leukemia. The pharmacological data science approach provides successful selections of drug candidates within development and repurposing tasks. © 2016 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.

  1. Pharmacologic and non-pharmacologic treatments for chronic pain in individuals with HIV: a systematic review (United States)

    Merlin, Jessica S.; Bulls, Hailey W.; Vucovich, Lee A.; Edelman, E. Jennifer; Starrels, Joanna L.


    Chronic pain occurs in as many as 85% of individuals with HIV and is associated with substantial functional impairment. Little guidance is available for HIV providers seeking to address their patients’ chronic pain. We conducted a systematic review to identify clinical trials and observational studies that examined the impact of pharmacologic or non-pharmacologic interventions on pain and/or functional outcomes among HIV-infected individuals with chronic pain in high-development countries. Eleven studies met inclusion criteria and were mostly low or very low quality. Seven examined pharmacologic interventions (gabapentin, pregabalin, capsaicin, analgesics including opioids) and four examined non-pharmacologic interventions (cognitive behavioral therapy, self-hypnosis, smoked cannabis). The only controlled studies with positive results were of capsaicin and cannabis, and had short-term follow-up (≤12 weeks). Among the seven studies of pharmacologic interventions, five had substantial pharmaceutical industry sponsorship. These findings highlight several important gaps in the HIV/chronic pain literature that require further research. PMID:27267445

  2. Methicillin-resistant Staphylococcus aureus: laboratory detection methods in use in the Republic of Ireland and Northern Ireland.

    LENUS (Irish Health Repository)

    Humphreys, H


    There is no universally agreed laboratory protocol for the detection of methicillin-resistant Staphylococcus aureus (MRSA) and hence a variety of approaches are used. As part of an all-island survey of MRSA in the Republic of Ireland (the South) and Northern Ireland (the North), a questionnaire was circulated to 14 participating laboratories in the North and 49 in the South, to determine the methods used to isolate MRSA from clinical specimens, identify S. aureus and test for susceptibility to methicillin. Almost two-thirds (64%) of laboratories in the North but only 16% of laboratories in the South use enrichment culture. There is heavy reliance on commercial kits to confirm the identification of S. aureus in the South but all laboratories in the North use the staphylocoagulase test. More than 90% of all laboratories use a disc method for susceptibility testing and 71% of laboratories in the North supplement this with the E-test; however, a range of methicillin disk concentrations are in use. There is a need to review current laboratory methods used to detect MRSA, with follow-up audit on their implementation. Additional resources may be needed in some laboratories to comply with revised guidelines, and reference facilities are required to assess new commercially available techniques and to confirm the identification of unusual or difficult strains.

  3. The genus Desmodium (Fabaceae)-traditional uses in Chinese medicine, phytochemistry and pharmacology. (United States)

    Ma, Xueqin; Zheng, Chengjian; Hu, Changling; Rahman, Khalid; Qin, Luping


    Plants of the genus Desmodium (Fabaceae), such as Desmodium styracifolium (Osbeck) Merr. and Desmodium gyrans (L. f.) DC., have a long history of medical use in Traditional Chinese Medicine to treat various ailments including rheumatism, pyrexia, dysentery, wounds, cough, malaria, hepatitis, hemoptysis, etc. In the theory of Traditional Chinese Medicine, most species have the effect of relieving internal heat or fever, neutralizing toxins, inhibiting pain, invigorating blood circulation, suppressing cough and alleviating dyspnea. A bibliographic investigation was accomplished by analyzing secondary sources including Chinese Herbal Classics, and worldwide accepted scientific databases (Pubmed, Scopus and Web of Science, SciFinder) were scrutinized for the available information on the ethnopharmacological uses in Chinese medicine, phytochemistry, pharmacology and toxicology of Desmodium species. The genus Desmodium is a large member of the Papilionaceae (Fabaceae) family. It contains about 350 plant species used for both feeding stuffs and herbal medicines, of which only about 30 species have been phytochemically or pharmacologically investigated. Desmodium plant extracts, as well as the active principles, have been experimentally studied for their anti-inflammatory, cytotoxic, antidiabetic, antinephrolithic, antibacterial, and nootropic activities in vitro or in vivo. And so far, a total of 212 compounds have been isolated from 15 Desmodium species and characterized mainly as flavonoids and alkaloids, followed by terpenoids, steroids, phenols, phenylpropanoids, glycosides and a number of volatile oils. The remaining unrevealed species are recorded chiefly in Asia and Africa being used in empirical treatment for various diseases. Desmodium species have long been used in TCM to treat various ailments. Available scientific references revealed that the traditional medical uses of some important Desmodium species in TCM have been evaluated by modern pharmacological

  4. A review on traditional uses, phytochemistry, pharmacology, pharmacokinetics and toxicology of the genus Peganum. (United States)

    Li, Shuping; Cheng, Xuemei; Wang, Changhong


    The plants of the genus Peganum have a long history as a Chinese traditional medicine for the treatment of cough, hypertension, diabetes, asthma, jaundice, colic, lumbago, and many other human ailments. Additionally, the plants can be used as an amulet against evil-eye, dye and so on, which have become increasingly popular in Asia, Iran, Northwest India, and North Africa. The present paper reviewed the ethnopharmacology, phytochemistry, analytical methods, biological activities, metabolism, pharmacokinetics, toxicology, and drug interaction of the genus Peganum in order to assess the ethnopharmacological use and to explore therapeutic potentials and future opportunities for research. Information on studies of the genus Peganum was gathered via the Internet (using Google Scholar, Baidu Scholar, Elsevier, ACS, Pudmed, Web of Science, CNKI and EMBASE) and libraries. Additionally, information was also obtained from some local books, PhD and MS's dissertations. The genus Peganum has played an important role in traditional Chinese medicine. The main bioactive metabolites of the genus include alkaloids, flavonoids, volatile oils, etc. Scientific studies on extracts and formulations revealed a wide range of pharmacological activities, such as cholinesterase and monoamine oxidase inhibitory activities, antitumor, anti-hypertension, anticoagulant, antidiabetic, antimicrobial, insecticidal, antiparasidal, anti-leishmaniasis, antioxidant, and anti-inflammatory. Based on this review, there is some evidence for extracts' pharmacological effects on Alzheimer's and Parkinson's diseases, cancer, diabetes, hypertension. Some indications from ethnomedicine have been confirmed by pharmacological effects, such as the cholinesterase, monoamine oxidase and DNA topoisomerase inhibitory activities, hypoglycemic and vasodilation effects of this genus. The available literature showed that most of the activities of the genus Peganum can be attributed to the active alkaloids. Data regarding

  5. Recent trends in phytochemistry, ethnobotany and pharmacological significance of Alchornea cordifolia (Schumach. & Thonn.) Muell. Arg. (United States)

    Boniface, Pone Kamdem; Ferreira, Sabrina Baptista; Kaiser, Carlos Roland


    phytoconstituents. The present review indicated that A. cordifolia is a valuable medicinal plant with multiple pharmacological effects. However, further research on the pharmacological mechanism of action of this plant is recommended in order to unravel the pharmacokinetics, pharmacodynamics, clinical relevance and toxicity of its extracts as well as constituents. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  6. Pharmacology Goes Concept-Based: Course Design, Implementation, and Evaluation. (United States)

    Lanz, Amelia; Davis, Rebecca G

    Although concept-based curricula are frequently discussed in the nursing education literature, little information exists to guide the development of a concept-based pharmacology course. Traditionally, nursing pharmacology courses are taught with an emphasis on drug class where a prototype drug serves as an exemplar. When transitioning pharmacology to a concept-based course, special considerations are in order. How can educators successfully integrate essential pharmacological content into a curriculum structured around nursing concepts? This article presents one approach to the design and implementation of a concept-based undergraduate pharmacology course. Planning methods, supportive teaching strategies, and course evaluation procedures are discussed.

  7. Palaeoflood evidence on the River Nore, South East Ireland (United States)

    Fleming, Ciara; Turner, Jonathan; Bourke, Mary


    Past geomorphic changes can be detected in sediment sinks, through the investigation of natural sediment archives. Since the advent of palaeoflood hydrology in the 1980s, numerous authors have demonstrated that such sediment deposits record valuable evidence of past flooding events. Many of these studies have focussed on fluvial systems in arid environments, with bedrock channels proving to be particularly successful field sites. In some districts, the collected datasets are now routinely employed to augment analyses of flood frequency and magnitude, which have traditionally relied on extrapolation of short hydrometric datasets. This study targets river reaches in a temperate humid environment, with a predominantly alluvial channel. The River Nore is one of the largest catchments draining South East Ireland. It is situated in a valley with an inherited glacial legacy and is principally a lowland river catchment. Specific morphological zones have been targeted which are optimal for flood deposit preservation, including palaeochannels, tributary junctions and floodplain overbank settings.There are a variety of anthropogenic pressures evident in this landscape. Among them are channelisation of select tributaries, a legacy of coal mining in the upland Carboniferous limestones, and the installation of man-made obstacles or modifications along the length of the river channel such as sluices and weirs. Regarding land-use, the majority of the catchment is dominated by agriculture, mainly pasture with some tillage. This study investigates palaeoflood evidence in the River Nore catchment and examines the development of the river floodplain using a variety of complementary field and desk-based methods. The sub-surface and micro-topography of river reaches are investigated using Ground Penetrating Radar (GPR) and Unmanned Aerial Vehicle (UAV) technology. Flood deposits have been characterised by examination of bank exposures and sediment cores. Installation of sediment traps

  8. Annual Report and Accounts 2000 Radiological Protection Institute of Ireland

    International Nuclear Information System (INIS)


    This report outlines the work of the Radiological Protection Institute of Ireland (RPII) during 2000. The report highlights its report published a year ago on the safety of the storage tanks holding liquid high-level radioactive waste at Sellafield. This report has gained heightened relevance from the fear, following September 11, of a terrorist attack on Sellafield. Also detailed in the report is the programme of monitoring of the radioactive contamination of the Irish sea caused by discharges from Sellafield which continues to be an important area of the Institute's work. A major focus is on the levels of technetium-99, which rose sharply from 1994 to 1998. Since 1998 these levels have begun to decrease, but are still considerably above pre-1994 levels, and remain a significant cause of concern. Also of considerable current interest is the key role assigned to the Institute under the National Emergency Plan for Nuclear Accidents. The Institute has further developed the capability of the computer model ARGOS (Accident Reporting and Guiding Operational System), which would enable it to predict the dispersion pattern of a plume of radioactive material being transported in the atmosphere towards Ireland from a disaster at a nuclear installation overseas. This prediction would be a vital element in ensuring an optimum response to a nuclear disaster affecting Ireland. The lung cancer risk associated with exposure to high levels of naturally occurring radon gas in buildings continues to be an important concern for the Institute. The Institute's nationwide survey of radon levels in primary and secondary level schools, commissioned by the Minister for Education and Science, and aimed at eliminating the exposure of children and staff to elevated radon levels in schools, has been highly successful and is entering its final stages. New legislation introduced in 2000 addresses the issue of radon in workplaces, and the Institute's implementation of this legislation has got

  9. Discursive Representations of Asylum Seekers and Illegal Immigrants in Ireland

    Directory of Open Access Journals (Sweden)

    Elaine Burroughs


    Full Text Available Migrants are often referred to as an all encompassing group of people and the “many faces of migration”, the variety of people, legalities and complexities involved, can be overlooked. The same can be said for non-EU migrants in the Irish context. Non-EU migrants (or those that are not Caucasian are generally viewed to be a distinct cohort of comparable migrants. Indeed, these migrants are often portrayed in a broadly negative way by key Irish institutions (such as the parliament or the media, and these representations impact upon how Irish society views non-EU migration and indeed migration in general. While Ireland is by no means the only European country in which this type of practice occurs, this paper aims to draw attention to generalized, inaccurate and misleading representations of non-EU migrants in Ireland, by specifically examining representations of asylum seekers and illegal immigrants. There can be an overlap in how these “types” of migrants are conceptualized and this paper therefore aims to develop an understanding of the implications involved for migrants categorized as an “asylum seeker” or an “illegal immigrant.” Furthermore, these topics are under-researched within the Irish context, yet they receive much political and public attention. At the same time however, this paper aims to challenge the labels assigned to non-EU migrants and the terminology that is used to define their identity so concretely. In the Irish context there is much confusion in relation to the multiple “faces” of non-EU migration, as a range of terminology is used to refer to them. This terminology is often used in an interchangeable manner, in an array of societal contexts. There is a consistent (whether this happens intentionally or unintentionally is debatable misuse of categories and migration terminology in Irish institutional discourses. Quite often those seeking asylum are referred to as illegal immigrants and vice versa

  10. World-Ecology and Ireland: The Neoliberal Ecological Regime

    Directory of Open Access Journals (Sweden)

    Sharae Deckard


    Full Text Available Since the collapse of the Celtic Tiger, the socio-economic particularity of neoliberal capitalism in its Irish manifestation has increasingly been critiqued, but little attention has been paid to neoliberalism as ecology within Ireland. This article conducts an exploratory survey of the characteristics of the Irish neoliberal ecological regime during and after the Celtic Tiger, identifying the opening of new commodity frontiers (such as fracking, water, agro-biotechnology, and biopharma constituted in the neoliberal drive to appropriate and financialize nature. I argue for the usefulness of applying not only the tools of world-systems analysis, but also Jason W. Moore’s world-ecological paradigm, to analysis of Ireland as a semi-periphery. What is crucial to a macro-ecological understanding of Ireland’s role in the neoliberal regime of the world-ecology is the inextricability of its financial role as a tax haven and secrecy jurisdiction zone from its environmental function as a semi-peripheral pollution and water haven. We can adapt Jason W. Moore’s slogan that “Wall Street…becomes a way of organizing all of nature, characterized by the financialization of any income-generating activity” (Moore 2011b: 39 to say that to say that the “IFSC is a way of organizing nature,” with pernicious consequences for water, energy, and food systems in Ireland. Financial service centers and pharmaceutical factories, plantations and cattle ranches, tax havens and pollution havens, empires and common markets are all forms of environment-making that constellate human relations and extra-human processes into new ecological regimes. More expansive, dialectical understandings of “ecology” as comprising the whole of socio-ecological relations within the capitalist world-ecology—from farming to pharma to financialization—are crucial to forming configurations of knowledge able not only to take account of Ireland’s role in the environmental

  11. Interprofessional education in pharmacology using high-fidelity simulation. (United States)

    Meyer, Brittney A; Seefeldt, Teresa M; Ngorsuraches, Surachat; Hendrickx, Lori D; Lubeck, Paula M; Farver, Debra K; Heins, Jodi R


    This study examined the feasibility of an interprofessional high-fidelity pharmacology simulation and its impact on pharmacy and nursing students' perceptions of interprofessionalism and pharmacology knowledge. Pharmacy and nursing students participated in a pharmacology simulation using a high-fidelity patient simulator. Faculty-facilitated debriefing included discussion of the case and collaboration. To determine the impact of the activity on students' perceptions of interprofessionalism and their ability to apply pharmacology knowledge, surveys were administered to students before and after the simulation. Attitudes Toward Health Care Teams scale (ATHCT) scores improved from 4.55 to 4.72 on a scale of 1-6 (p = 0.005). Almost all (over 90%) of the students stated their pharmacology knowledge and their ability to apply that knowledge improved following the simulation. A simulation in pharmacology is feasible and favorably affected students' interprofessionalism and pharmacology knowledge perceptions. Pharmacology is a core science course required by multiple health professions in early program curricula, making it favorable for incorporation of interprofessional learning experiences. However, reports of high-fidelity interprofessional simulation in pharmacology courses are limited. This manuscript contributes to the literature in the field of interprofessional education by demonstrating that an interprofessional simulation in pharmacology is feasible and can favorably affect students' perceptions of interprofessionalism. This manuscript provides an example of a pharmacology interprofessional simulation that faculty in other programs can use to build similar educational activities. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Dental caries experience and barriers to care in young children with disabilities in Ireland. (United States)

    Sagheri, Darius; McLoughlin, Jacinta; Nunn, June H


    Dental caries among preschool children remains a significant dental public health problem. In Ireland, there are no national data available regarding dental caries levels in preschool children. Furthermore, the number of young children with disabilities and their dental caries levels remains unknown. The aim of the present study was to measure the dental caries levels in a sample of preschool children with disabilities. A team of trained and calibrated dentists examined a sample of all 0- to 6-year old preschool children with disabilities in two health service administrative areas under standardized conditions. Dental caries was recorded using WHO criteria. Of a total of 422 participants, 337 datasets were included in the study. Of these 337 examined children, approximately 75.1% had a cognitive disability and 12.9% had a noncognitive disability. In 12% of the children, a diagnosis had not yet been established. Dental caries at dentin level was detected from the age of 4 years. The overall mean decayed/missing/ filled teeth (dmft) was 0.49 (SD, 1.39). The analysis of mean dmft levels in children with positive (dmft > 0) scores revealed a mean dmft of 1.14. The evidence from this study demonstrated that dental caries levels in preschool children with disabilities in Ireland are low when compared with the general population. Furthermore, children aged 3 years or younger exhibited no dental caries at dentin level and therefore were not affected by early childhood caries. An adjustment of current oral health prevention practice may lead to a further reduction in dental caries levels in this section of the child population.

  13. A longitudinal study through adolescence to adulthood: the Young Hearts Project, Northern Ireland. (United States)

    Gallagher, A M; Savage, J M; Murray, L J; Davey Smith, G; Young, I S; Robson, P J; Neville, C E; Cran, G; Strain, J J; Boreham, C A


    The Young Hearts (YH) Project is an ongoing study of biological and behavioural risk factors for cardiovascular disease in a representative sample of young people from Northern Ireland, a region of high coronary mortality. This article describes the cross-sectional clinical, dietary and lifestyle data obtained from individuals (aged 20-25 y) who participated in phase 3 of the project (YH3). A total of 489 individuals (251 males, 238 females) participated in YH3 (48.2% response rate). Some 31.1% of participants at YH3 were overweight (BMI >25 kg/m(2)) with 4.4% of males and 8.0% of females were obese (BMI >30 kg/m(2)). More females than males had a very poor fitness (55.0 vs 22.1%, chi-squared 51.70, d.f. 1, P5.2 mmol/l). More females had a raised serum LDL-cholesterol (>3.0 mmol/l) than males (44.6 vs 34.6%, chi-squared 4.39, d.f. 1, Pevil: the medical consequences of alcohol abuse. Tavistock: London, 1987), with 36.7% of males and 13.4% of females reporting intakes over twice these recommended limits. A total of 37% of the study population smoked. During young adulthood, individuals may be less amenable to attend a health-related study and recruitment of participants to the current phase of the study proved a major problem. However, these data constitute a unique developmental record from adolescence to young adulthood in a cohort from Northern Ireland and provide additional information on the impact of early life, childhood and young adulthood on the development of risk for chronic disease.

  14. Session 1: Public health nutrition. Breast-feeding practices in Ireland.

    LENUS (Irish Health Repository)

    Tarrant, R C


    Breast-feeding is the superior infant feeding method from birth, with research consistently demonstrating its numerous short- and long-term health benefits for both mother and infant. As a global recommendation the WHO advises that mothers should exclusively breast-feed for the first 6-months of life, thus delaying the introduction of solids during this time. Historically, Irish breast-feeding initiation rates have remained strikingly low in comparison with international data and there has been little improvement in breast-feeding duration rates. There is wide geographical variation in terms of breast-feeding initiation both internationally and in Ireland. Some of these differences in breast-feeding rates may be associated with differing socio-economic characteristics. A recent cross-sectional prospective study of 561 pregnant women attending a Dublin hospital and followed from the antenatal period to 6 months post partum has found that 47% of the Irish-national mothers initiated breast-feeding, while only 24% were still offering \\'any\\' breast milk to their infants at 6 weeks. Mothers\\' positive antenatal feeding intention to breast-feed is indicated as one of the most important independent determinants of initiation and \\'any\\' breast-feeding at 6 weeks, suggesting that the antenatal period should be targeted as an effective time to influence and affect mothers\\' attitudes and beliefs pertaining to breast-feeding. These results suggest that the \\'cultural\\' barrier towards breast-feeding appears to still prevail in Ireland and consequently an environment that enables women to breast-feed is far from being achieved. Undoubtedly, a shift towards a more positive and accepting breast-feeding culture is required if national breast-feeding rates are to improve.

  15. Self-rated health literacy is associated with exercise frequency among adults aged 50+ in Ireland. (United States)

    Gibney, S; Doyle, G


    The aim of this study was to investigate the relationship between self-rated health literacy and self-reported exercise frequency among people aged 50+ in Ireland. Data were from the European Health Literacy Survey (2011) a nationally representative, cross-sectional survey of adults aged 15+ from eight countries. Health literacy was measured using composite indices (0-50, low to high) in three domains: healthcare, disease prevention and health promotion. Participants reported how often they exercised for 30 min or longer in the month prior to survey. Multivariate logistic regression analysis was used to examine the association between exercise frequency (almost daily activity vs. weekly or less) and health literacy among participants aged 50+ in Ireland (n = 389). All models were fully adjusted for age, gender, employment status, marital status, social status, education, financial deprivation and having a physically limiting illness. An increased odds of exercising almost daily was associated with understanding disease prevention (OR = 1.18, 95% CI 1.03-1.35) and health promotion information (OR = 1.15, 95% CI 1.01-1.32) and accessing (OR = 1.13, 95% CI 1.00-1.29) and evaluating health promotion information (OR = 1.12, 95% CI 1.00-1.26) with ease. Public health approaches to promoting exercise often include providing information about the benefits of regular exercise, promoting affordable options and enhancing the accessibility of the built environment. Public health policy should also consider measures to improve interactive health literacy skills in order to achieve positive behavioural change. © The Author 2017. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved.

  16. Adolescent self-harm: a school-based study in Northern Ireland. (United States)

    O'Connor, Rory C; Rasmussen, Susan; Hawton, Keith


    The prevalence of adolescent self-harm in Northern Ireland (NI) and its associated factors are unknown. Given the established relationship between conflict and mental health, and NI׳s recent history of conflict, it is important to investigate the factors associated with self-harm in NI. This study aimed to determine the prevalence of self-harm in NI adolescents and the factors associated with it, including exposure to the NI conflict. Observational study of 3596 school pupils employing an anonymous self-report survey. Information was obtained on demographic characteristics, lifestyle, life events and problems, exposure to the NI conflict, social and internet influences, and psychological variables. Self-harm was reported by 10% of respondents. In univariate analyses, exposure to the NI conflict was associated with self-harm alongside established risk factors. In multivariate analyses, bullying and exposure to self-harm were associated with lifetime self-harm in both girls and boys. Alcohol use, drug use, physical and sexual abuse, and self-esteem were also associated with self-harm in girls. In boys, absence of exercise, sexual orientation concerns, anxiety and impulsivity were additional risk factors. The internet/social media and the self-harm of others were also key influences. This is a cross-sectional study. The rate of self-harm was lower than elsewhere in the UK/Ireland. The study highlights the factors which should be considered in terms of risk assessment. In addition to established risk factors, the findings suggest that more research on the legacy of the NI conflict as well as the influence of new technologies warrant urgent attention. Copyright © 2014 Elsevier B.V. All rights reserved.

  17. Chernobyl - 10 years on. Proceedings of a conference organised by the Radiological Protection Institute of Ireland

    Energy Technology Data Exchange (ETDEWEB)



    The consequences of the Chernobyl nuclear accident from an Irish perspective was the focus of a conference organised by the Radiological Protection Institute of Ireland to mark the tenth anniversary of the accident. The health consequences of Chernobyl were discussed along with presentations on such issues as the hazards to the Irish population from Sellafield; the radiation hazard posed by radon gas; radiation hazards in medicine, industry and education, and Ireland`s National Emergency Plan for Nuclear Accidents.

  18. An assessment of aquatic radiation pathways in Ireland, 2008 Environment Report RL 16/08

    International Nuclear Information System (INIS)

    Clyne, F.J.; Garrod, C.J.; Jeffs, T.M; Jenkinson, S.B


    This report provides an assessment of aquatic radiation exposure pathways in Ireland relating to anthropogenic radioactivity in the Irish Sea. It comprises the results of a habits survey undertaken on the north east coast of Ireland; a dose assessment using the habits survey data; 2007 monitoring data provided by the RPII; and recommendations for changes to the 2007 east coast of Ireland marine monitoring programme conducted by the RPII

  19. Soldiers of Destiny: The Fianna Fail Party, The Irish Republican Army and a United Ireland (United States)


    Republicas sead aside and let the Treaty cme into force, it eans acguiescen in and the aba n nt of the national sovereignty and in the partition of our...prevented the bipolar divisions that have plagued Ireland Sn . 2. Basil Cuibb, The Goveninent and Politics of Ireland, 2rd ed. (Stanford: Stanford...p 2_0 15. Paul Arthur and Keith Jeffery, Northern Ireland Since ~ (Oxford: Basil Blackwell, 1988), p. 37. 16. Kelley, p. 127. 17. Ibid., p. 128. 101

  20. Urinary phthalate concentrations in mothers and their children in Ireland

    DEFF Research Database (Denmark)

    Cullen, Elizabeth; Evans, David; Griffin, Chris


    . This study aimed to determine the extent of phthalate exposure among mothers and their children in both rural and urban areas in Ireland, and to identify factors associated with elevated concentrations. It formed part of the ‘Demonstration of a study to Co-ordinate and Perform Human Biomonitoring...... on a European Scale’ (DEMOCOPHES) pilot biomonitoring study. Methods: the concentration of phthalate metabolites were determined from a convenience sample of 120 mother/child pairs. The median age of the children was 8 years. A questionnaire was used to collect information regarding lifestyle and environmental...... conditions of the children and mothers. Rigorous quality assurance within DEMOCOPHES guaranteed the accuracy and international comparability of results. Results: Phthalate metabolites were detected in all of the samples from both children and mothers. Concentrations were significantly higher in respondents...

  1. The development of IVF practice in Ireland: a personal view.

    LENUS (Irish Health Repository)

    Harrison, Robert F


    This paper traces the development of in vitro fertilization (IVF) in the Republic of Ireland from when the first attempts at using this technique were carried out in 1985 up to the present. Clinical changes are chronicled principally using the personal work of the author and his colleagues as representative of the day. The impact of the Catholic Church and the alterations in Medical Council governance guidelines over the years as these reflect societal changes are highlighted. The potential role of other regulators including Irish case law and the EU Tissue directive are discussed as well as the almost invariable private practice nature of the services provided and the various ways in which costs have been alleviated.

  2. An economic assessment of potential ethanol production pathways in Ireland

    Energy Technology Data Exchange (ETDEWEB)

    Deverell, Rory; McDonnell, Kevin; Ward, Shane; Devlin, Ger [Department of Biosystems Engineering, Agriculture and Food Science Building, University College Dublin 4, Belfield (Ireland)


    An economic assessment was conducted on five biomass-to-ethanol production pathways utilising the feedstock: wheat, triticale, sugarbeet, miscanthus and straw. The analysis includes the costs and margins for all the stakeholders along the economic chain. This analysis reveals that under current market situations in Ireland, the production of ethanol under the same tax regime as petrol makes it difficult to compete against that fuel, with tax breaks, however, it can compete against petrol. On the other hand, even under favourable tax breaks it will be difficult for indigenously produced ethanol to compete against cheaper sources of imported ethanol. Therefore, the current transport fuel market has no economic reason to consume indigenously produced ethanol made from the indigenously grown feedstock analysed at a price that reflects all the stakeholders' costs. To deliver a significant penetration of indigenous ethanol into the market would require some form of compulsory inclusion or else considerable financial supports to feedstock and ethanol producers. (author)

  3. Transforming youth mental health services and supports in Ireland. (United States)

    Illback, Robert J; Bates, Tony


    Young people in the Republic of Ireland do not have access to appropriate mental health services and supports, necessitating transformational change in delivery systems. Describe ongoing development and change efforts facilitated by Headstrong--The National Centre for Youth Mental Health. Discusses findings from a national needs assessment, core strategies within the change initiative, progress in system-building, and preliminary descriptive and outcome data. Five demonstration sites comprised of four counties and a city neighbourhood are operational and preliminary data are promising with respect to implementation and outcomes. Effective change initiatives require vision and leadership, competence- and capacity-building, participative planning and engagement, adequate and thoughtfully deployed resources, and a comprehensive change management approach. © 2011 Blackwell Publishing Asia Pty Ltd.

  4. Domestic hot water and solar energy in Ireland

    Energy Technology Data Exchange (ETDEWEB)

    Hand, F; Asare, B; Haslett, J


    Two systems are discussed which involve the use of solar energy to supply domestic hot-water requirements and their usefulness in Ireland is examined. The systems are evaluated for thermal performance and cost-effectiveness by the use of a computer simulation model of a system involving a typical commercially available solar panel. It is shown that such systems may be economically justified when compared with electricity, but only if the water supply is directly heated by solar panels and only if the installed cost of such panels is low. Further, it appears that the system performance is relatively insensitive to the panel orientation and consequently that retro-fit installations on existing houses are unlikely to cause difficulties.

  5. Occupational noise exposure of nightclub bar employees in Ireland

    Directory of Open Access Journals (Sweden)

    Aoife C Kelly


    Full Text Available Due to the transposition of the EU Directive 2003/10/EC into Irish Law, the entertainment sector was obligated to comply with the requirements of the Safety, Health and Welfare at Work (General Application Regulations 2007, Chapter 1 Part 5: Control of Noise at Work since February 2008. Compliance with the Noise Regulations was examined in 9 nightclubs in Ireland. The typical daily noise exposure of 19 bar employees was measured using 2 logging dosimeters and a Type 1 fixed position sound level meter. Physical site inspections identified nightclub noise control measures. Interviews and questionnaires were used to assess the managers and employees awareness of the noise legislation. The average bar employee daily noise exposure (L EX, 8h was 92 dBA, almost 4 times more than the accepted legal limit. None of the venues examined were fully compliant with the requirements of the 2007 Noise Regulations, and awareness of this legislation was limited.

  6. Health insurance and health services utilization in Ireland. (United States)

    Harmon, C; Nolan, B


    The numbers buying private health insurance in Ireland have continued to grow, despite a broadening in entitlement to public care. About 40% of the population now have insurance, although everyone has entitlement to public hospital care. In this paper, we examine in detail the growth in insurance coverage and the factors underlying the demand for insurance. Attitudinal responses reveal the importance of perceptions about waiting times for public care, as well as some concerns about the quality of that care. Individual characteristics, such as education, age, gender, marital status, family composition and income all influence the probability of purchasing private insurance. We also examine the relationship between insurance and utilization of hospital in-patient services. The positive effect of private insurance appears less than that of entitlement to full free health care from the state, although the latter is means-tested, and may partly represent health status. Copyright 2001 John Wiley & Sons, Ltd.

  7. Occupational noise exposure of nightclub bar employees in Ireland. (United States)

    Kelly, Aoife C; Boyd, Sara M; Henehan, Gary T M; Chambers, Gordon


    Due to the transposition of the EU Directive 2003/10/EC into Irish Law, the entertainment sector was obligated to comply with the requirements of the Safety, Health and Welfare at Work (General Application) Regulations 2007, Chapter 1 Part 5: Control of Noise at Work since February 2008. Compliance with the Noise Regulations was examined in 9 nightclubs in Ireland. The typical daily noise exposure of 19 bar employees was measured using 2 logging dosimeters and a Type 1 fixed position sound level meter. Physical site inspections identified nightclub noise control measures. Interviews and questionnaires were used to assess the managers and employees awareness of the noise legislation. The average bar employee daily noise exposure (L(EX, 8h)) was 92 dBA, almost 4 times more than the accepted legal limit. None of the venues examined were fully compliant with the requirements of the 2007 Noise Regulations, and awareness of this legislation was limited.

  8. An economic assessment of potential ethanol production pathways in Ireland

    International Nuclear Information System (INIS)

    Deverell, Rory; McDonnell, Kevin; Ward, Shane; Devlin, Ger


    An economic assessment was conducted on five biomass-to-ethanol production pathways utilising the feedstock: wheat, triticale, sugarbeet, miscanthus and straw. The analysis includes the costs and margins for all the stakeholders along the economic chain. This analysis reveals that under current market situations in Ireland, the production of ethanol under the same tax regime as petrol makes it difficult to compete against that fuel, with tax breaks, however, it can compete against petrol. On the other hand, even under favourable tax breaks it will be difficult for indigenously produced ethanol to compete against cheaper sources of imported ethanol. Therefore, the current transport fuel market has no economic reason to consume indigenously produced ethanol made from the indigenously grown feedstock analysed at a price that reflects all the stakeholders' costs. To deliver a significant penetration of indigenous ethanol into the market would require some form of compulsory inclusion or else considerable financial supports to feedstock and ethanol producers.

  9. Comparison Of Development: Ireland, South Korea, Finland And Costa Rica


    Jiménez Gómez, Roberto


    The article compares the development followed by Finland, South Korea and Ireland and compares in some ways with which Costa Rica has had. The initial situation starts in the 1960s, the policies pursued by each country in the context of their models and then, sets the current situation of these countries. Finally, define some lessons learned by the nations, the result of the achievements and challenges of development. El artículo compara, en ciertos aspectos, el desarrollo que ha tenido Fi...

  10. Trailblazers and Cassandras: Other Voices in Northern Ireland

    DEFF Research Database (Denmark)

    McQuaid, Sara Dybris


    ’ voices and alternative positions in the process of conflict interpretation and resolution. This essay will outline a ‘thumbnail’ sketch of three areas in which ‘other’ voices are sidelined or silenced: in terms of political discourses; community discourses; and wider academic and public discourses......’ and ‘Cassandras’ the essay concludes that the arguments forwarded by other voices are not disappeared but adapted and realigned to the reigning discourses, and that there is not so much a culture of silence surrounding ‘other’ voices as a certain selective and sectarian hearing in picking them up. Whilst...... it follows that ‘other’ voices have failed to dissolve the magnetic field of Northern Irish politics, the essay suggests that in order to rise to current political challenges in Northern Ireland it is worthwhile sounding out the historical and contemporary ‘other’ voices for carefully thought out and non...

  11. Suicide and changing values and beliefs in Ireland. (United States)

    Cleary, Anne; Brannick, Teresa


    This paper addresses some of the generalized theories explaining rising suicide rates in Ireland. The conclusion here is that linking suicide patterns to changing beliefs and values is problematic. Church attendance as well as adherence to traditional values remain high in this country compared to European levels, and variations in beliefs and values, especially rural/urban differences, do not fit with general explanations. Moreover, attitudes to value areas fluctuate in that justification for suicide--which showed an upward trend in the 1980s--was reversed in the 1990s, and this may have resulted from increased public focus and debate. Generalized explanations are unlikely to decipher complex phenomena such as suicidal behavior. Religious belief, if protective in relation to suicide, is unlikely to act alone. Social transformations have a differential impact depending on one's socio-economic positioning, which translates ideas of a general male vulnerability to suicide into focused areas of male distress.

  12. Publication productivity of neurosurgeons in Great Britain and Ireland. (United States)

    Wilkes, Fiona A; Akram, Harith; Hyam, Jonathan A; Kitchen, Neil D; Hariz, Marwan I; Zrinzo, Ludvic


    Bibliometrics are the methods used to quantitatively analyze scientific literature. In this study, bibliometrics were used to quantify the scientific output of neurosurgical departments throughout Great Britain and Ireland. A list of neurosurgical departments was obtained from the Society of British Neurological Surgeons website. Individual departments were contacted for an up-to-date list of consultant (attending) neurosurgeons practicing in these departments. Scopus was used to determine the h-index and m-quotient for each neurosurgeon. Indices were measured by surgeon and by departmental mean and total. Additional information was collected about the surgeon's sex, title, listed superspecialties, higher research degrees, and year of medical qualification. Data were analyzed for 315 neurosurgeons (25 female). The median h-index and m-quotient were 6.00 and 0.41, respectively. These were significantly higher for professors (h-index 21.50; m-quotient 0.71) and for those with an additional MD or PhD (11.0; 0.57). There was no significant difference in h-index, m-quotient, or higher research degrees between the sexes. However, none of the 16 British neurosurgery professors were female. Neurosurgeons who specialized in functional/epilepsy surgery ranked highest in terms of publication productivity. The 5 top-scoring departments were those in Addenbrooke's Hospital, Cambridge; St. George's Hospital, London; Great Ormond Street Hospital, London; National Hospital for Neurology and Neurosurgery, Queen Square, London; and John Radcliffe Hospital, Oxford. The h-index is a useful bibliometric marker, particularly when comparing between studies and individuals. The m-quotient reduces bias toward established researchers. British academic neurosurgeons face considerable challenges, and women remain underrepresented in both clinical and academic neurosurgery in Britain and Ireland.

  13. A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris. (United States)

    Zhu, Wenyi; Du, Yijie; Meng, Hong; Dong, Yinmao; Li, Li


    Tribulus terrestris L. (TT) is an annual plant of the family Zygophyllaceae that has been used for generations to energize, vitalize, and improve sexual function and physical performance in men. The fruits and roots of TT have been used as a folk medicine for thousands of years in China, India, Sudan, and Pakistan. Numerous bioactive phytochemicals, such as saponins and flavonoids, have been isolated and identified from TT that are responsible alone or in combination for various pharmacological activities. This review provides a comprehensive overview of the traditional applications, phytochemistry, pharmacology and overuse of TT and provides evidence for better medicinal usage of TT.

  14. Pharmacological studies of the lung with PET

    International Nuclear Information System (INIS)

    Syrota, A.


    Positron emission tomography (PET), known to be used for lung ventilation and perfusion studies, can also be used in pharmacology to obtain information that is otherwise not available. The lung takes up biologically active substances which can be inactivated or activated, and synthesises and releases others. Such information in man has been obtained from samples of human lungs, or from in vivo first-pass studies, invasive or not, as well as from in vivo kinetic studies using external detection methods with scintillation cameras. PET provides now quantitative regional data in the human lung

  15. Chemistry and Pharmacology of Citrus sinensis

    Directory of Open Access Journals (Sweden)

    Juan Manuel J. Favela-Hernández


    Full Text Available Presently the search for new drugs from natural resources is of growing interest to the pharmaceutical industry. Natural products have been the source of new drugs since ancient times. Plants are a good source of secondary metabolites which have been found to have beneficial properties. The present study is a review of the chemistry and pharmacology of Citrus sinensis. This review reveals the therapeutic potential of C. sinensis as a source of natural compounds with important activities that are beneficial for human health that could be used to develop new drugs.

  16. [Pharmacological aspects of pain research in Germany]. (United States)

    Niederberger, E; Kuner, R; Geißlinger, G


    In spite of several approved analgesics, the therapy of pain still constitutes a challenge due to the fact that the drugs do not exert sufficient efficacy or are associated with severe side effects. Therefore, the development of new and improved painkillers is still of great importance. A number of highly qualified scientists in Germany are investigating signal transduction pathways in pain, effectivity of new drugs and the so far incompletely investigated mechanisms of well-known analgesics in preclinical and clinical studies. The highlights of pharmacological pain research in Germany are summarized in this article.

  17. Reappraisal of GIP Pharmacology for Metabolic Diseases

    DEFF Research Database (Denmark)

    Finan, Brian; Müller, Timo D; Clemmensen, Christoffer


    Glucagon-like peptide-1 (GLP-1) analogs are considered the best current medicines for type 2 diabetes (T2D) and obesity due to their actions in lowering blood glucose and body weight. Despite similarities to GLP-1, glucose-dependent insulinotropic polypeptide (GIP) has not been extensively pursue...... be beneficial for metabolic diseases. However, a growing body of new evidence - including data based on refined genetically modified models and improved pharmacological agents - suggests a paradigm shift on how the GIP system should be manipulated for metabolic benefits....

  18. The pharmacological management of metabolic syndrome. (United States)

    Rask Larsen, Julie; Dima, Lorena; Correll, Christoph U; Manu, Peter


    The metabolic syndrome includes a constellation of several well-established risk factors, which need to be aggressively treated in order to prevent overt type 2 diabetes and cardiovascular disease. While recent guidelines for the treatment of individual components of the metabolic syndrome focus on cardiovascular benefits as resulted from clinical trials, specific recent recommendations on the pharmacological management of metabolic syndrome are lacking. The objective of present paper was to review the therapeutic options for metabolic syndrome and its components, the available evidence related to their cardiovascular benefits, and to evaluate the extent to which they should influence the guidelines for clinical practice. Areas covered: A Medline literature search was performed to identify clinical trials and meta-analyses related to the therapy of dyslipidemia, arterial hypertension, glucose metabolism and obesity published in the past decade. Expert commentary: Our recommendation for first-line pharmacological are statins for dyslipidemia, renin-angiotensin-aldosteron system inhibitors for arterial hypertension, metformin or sodium/glucose cotransporter 2 inhibitors or glucagon-like peptide 1 receptor agonists (GLP-1RAs) for glucose intolerance, and the GLP-1RA liraglutide for achieving body weight and waist circumference reduction.

  19. Electronic cigarettes and nicotine clinical pharmacology. (United States)

    Schroeder, Megan J; Hoffman, Allison C


    To review the available literature evaluating electronic cigarette (e-cigarette) nicotine clinical pharmacology in order to understand the potential impact of e-cigarettes on individual users, nicotine dependence and public health. Literature searches were conducted between 1 October 2012 and 30 September 2013 using key terms in five electronic databases. Studies were included in the review if they were in English and publicly available; non-clinical studies, conference abstracts and studies exclusively measuring nicotine content in e-cigarette cartridges were excluded from the review. Nicotine yields from automated smoking machines suggest that e-cigarettes deliver less nicotine per puff than traditional cigarettes, and clinical studies indicate that e-cigarettes deliver only modest nicotine concentrations to the inexperienced e-cigarette user. However, current e-cigarette smokers are able to achieve systemic nicotine and/or cotinine concentrations similar to those produced from traditional cigarettes. Therefore, user experience is critically important for nicotine exposure, and may contribute to the products' ability to support and maintain nicotine dependence. Knowledge about e-cigarette nicotine pharmacology remains limited. Because a user's e-cigarette experience may significantly impact nicotine delivery, future nicotine pharmacokinetic and pharmacodynamic studies should be conducted in experienced users to accurately assess the products' impact on public health.

  20. Electronic cigarettes and nicotine clinical pharmacology (United States)

    Schroeder, Megan J; Hoffman, Allison C


    Objective To review the available literature evaluating electronic cigarette (e-cigarette) nicotine clinical pharmacology in order to understand the potential impact of e-cigarettes on individual users, nicotine dependence and public health. Methods Literature searches were conducted between 1 October 2012 and 30 September 2013 using key terms in five electronic databases. Studies were included in the review if they were in English and publicly available; non-clinical studies, conference abstracts and studies exclusively measuring nicotine content in e-cigarette cartridges were excluded from the review. Results Nicotine yields from automated smoking machines suggest that e-cigarettes deliver less nicotine per puff than traditional cigarettes, and clinical studies indicate that e-cigarettes deliver only modest nicotine concentrations to the inexperienced e-cigarette user. However, current e-cigarette smokers are able to achieve systemic nicotine and/or cotinine concentrations similar to those produced from traditional cigarettes. Therefore, user experience is critically important for nicotine exposure, and may contribute to the products’ ability to support and maintain nicotine dependence. Conclusions Knowledge about e-cigarette nicotine pharmacology remains limited. Because a user's e-cigarette experience may significantly impact nicotine delivery, future nicotine pharmacokinetic and pharmacodynamic studies should be conducted in experienced users to accurately assess the products’ impact on public health. PMID:24732160

  1. Neuro-pharmacological functional MRI of epilepsy

    Energy Technology Data Exchange (ETDEWEB)

    Kiriyama, Hideki; Makabe, Tetsuo; Tomita, Susumu; Omoto, Takashi; Asari, Shoji [Okayama Univ. (Japan). School of Medicine; Aihara, Hiroshi; Kinugasa, Kazushi; Nishimoto, Akira; Ito, Takahiko


    We studied patients with epilepsy by neuro-pharmacological functional MRI technique using diazepam. Five normal volunteers and 7 patients with epilepsy were investigated. MRI was performed by a 1.5 T unit (SIGNA Horizon, GE) using the following parameters: TR/TE 5000 msec/80 msec, FA 90 deg, FOV 200 mm, matrix 128 x 128, slice thickness 7 mm. We performed MRI scanning over 5 minutes (2 minutes before and 3 minutes after injection of diazepam) for each 1 session; we scanned 3 sessions for each patient at intervals of 5 minutes. The diazepam was injected rapidly from the antecubital vein. The dose of diazepam was 0.05 mg/kg/injection (total dose was 0.15 mg/kg). The data were analyzed statistically using t-test. Signal change after administration of diazepam was less than 1 to 2% in healthy volunteers. By contrast, in patient with epilepsy, the signal change was almost 3%, which was significantly greater than that of the normal area (p=0.01). The neuro-pharmacological functional MRI technique using diazepam might be a useful method to identify epileptic foci. (author)

  2. Pharmacological Effects of Niacin on Acute Hyperlipemia. (United States)

    la Paz, Sergio Montserrat-de; Bermudez, Beatriz; Naranjo, M Carmen; Lopez, Sergio; Abia, Rocio; Muriana, Francisco J G


    The well-known changes in modern lifestyle habits including over nutrition and physical inactivity have led to striking adverse effects on public health (e.g., obesity, diabetes, and metabolic syndrome) over recent decades. One noticeable consequence is exaggerated and prolonged state of postprandial hyperlipemia due to the ingestion of multiple fat-enriched meals during the course of a day. Postprandial (non-fasting) hyperlipemia is characterized by increased blood levels of exogenous triglycerides (TG) in the form of apolipoprotein (apo) B48-containing TG-rich lipoproteins (TRL), which have a causal role in the pathogenesis and progression of cardiovascular disease (CVD). The cardiovascular benefits of lifestyle modification (healthy diet and exercise) and conventional lipid-lowering therapies (e.g., statins, fibrates, and niacin) could involve their favourable effects on postprandial metabolism. Pharmacologically, niacin has been used as an athero-protective drug for five decades. Studies have since shown that niacin may decrease fasting levels of plasma verylow- density lipoproteins (VLDL), low-density lipoprotein cholesterol (LDL-C), and lipoprotein [a] (Lp[a]), while may increase high-density lipoprotein cholesterol (HDL-C). Herein, the purpose of this review was to provide an update on effects and mechanisms related to the pharmacological actions of niacin on acute hyperlipemia.

  3. Phytochemical and pharmacological review of Lagenaria sicereria. (United States)

    Prajapati, Rakesh P; Kalariya, Manisha; Parmar, Sachin K; Sheth, Navin R


    Lagenaria siceraria (Molina) standley (LS) (Family: Cucurbitaceae) is an annual herbaceous climbing plant with a long history of traditional medicinal uses in many countries, especially in tropical and subtropical regions. Since ancient times the climber has been known for its curative properties, and has been utilized for treatment of various ailments, including jaundice, diabetes, ulcer, piles, colitis, insanity, hypertension, congestive cardiac failure (CCF), and skin diseases. Its fruit pulp is used both as an emetic and purgative, and for its cooling, diuretic, antibilious, and pectoral properties. Boiled in oil this pulp is used to treat rheumatism and insomnia. A wide range of chemical compounds including sterols, terpenoids, flavonoids, and saponins have been isolated from the species. Its extracts have been found to possess various pharmacological activities. Below, we give a comprehensive review of its ethnomedical uses, chemical constituents, and pharmacological profile as a medicinal plant. Particular attention is given to its analgesic, anti-inflammatory, antihyperlipidemic, diuretic, hepatoprotective, anthelmintic, and antibacterial effects so that its potential uses in pharmaceutics can be better evaluated.

  4. Phytochemical and pharmacological review of Lagenaria sicereria

    Directory of Open Access Journals (Sweden)

    Rakesh P Prajapati


    Full Text Available Lagenaria siceraria (Molina standley (LS (Family: Cucurbitaceae is an annual herbaceous climbing plant with a long history of traditional medicinal uses in many countries, especially in tropical and subtropical regions. Since ancient times the climber has been known for its curative properties, and has been utilized for treatment of various ailments, including jaundice, diabetes, ulcer, piles, colitis, insanity, hypertension, congestive cardiac failure (CCF, and skin diseases. Its fruit pulp is used both as an emetic and purgative, and for its cooling, diuretic, antibilious, and pectoral properties. Boiled in oil this pulp is used to treat rheumatism and insomnia. A wide range of chemical compounds including sterols, terpenoids, flavonoids, and saponins have been isolated from the species. Its extracts have been found to possess various pharmacological activities. Below, we give a comprehensive review of its ethnomedical uses, chemical constituents, and pharmacological profile as a medicinal plant. Particular attention is given to its analgesic, anti-inflammatory, antihyperlipidemic, diuretic, hepatoprotective, anthelmintic, and antibacterial effects so that its potential uses in pharmaceutics can be better evaluated.

  5. Multiple sclerosis: general features and pharmacologic approach

    International Nuclear Information System (INIS)

    Nielsen Lagumersindez, Denis; Martinez Sanchez, Gregorio


    Multiple sclerosis is an autoimmune, inflammatory and desmyelinization disease central nervous system (CNS) of unknown etiology and critical evolution. There different etiological hypotheses talking of a close interrelation among predisposing genetic factors and dissimilar environmental factors, able to give raise to autoimmune response at central nervous system level. Hypothesis of autoimmune pathogeny is based on study of experimental models, and findings in biopsies of affected patients by disease. Accumulative data report that the oxidative stress plays a main role in pathogenesis of multiple sclerosis. Oxygen reactive species generated by macrophages has been involved as mediators of demyelinization and of axon damage, in experimental autoimmune encephalomyelitis and strictly in multiple sclerosis. Disease diagnosis is difficult because of there is not a confirmatory unique test. Management of it covers the treatment of acute relapses, disease modification, and symptoms management. These features require an individualized approach, base on evolution of this affection, and tolerability of treatments. In addition to diet, among non-pharmacologic treatments for multiple sclerosis it is recommended physical therapy. Besides, some clinical assays have been performed in which we used natural extracts, nutrition supplements, and other agents with promising results. Pharmacology allowed neurologists with a broad array of proved effectiveness drugs; however, results of research laboratories in past years make probable that therapeutical possibilities increase notably in future. (Author)


    Directory of Open Access Journals (Sweden)

    Anju Meshram


    Full Text Available Arginine is metabolically flexible amino acid with major role in protein synthesis and detoxification of ammonia. It is involved in several metabolic pathways for the production of biologically active compounds such as creatine, nitric oxide, ornithine, glutamate, agmatine, citrulline and polyamines. Regarding this all, we review the crucial role of arginine in metabolism, diversified prospective uses and pharmacological applications. Arginine plays an important role in the treatment of tumorigenesis, asthama, gastric, erectile dysfunction, apoptosis, melanoma and congestive heart failure. Ability to produce nitric oxide offers various applications as in the prevention of age and hair loss. It serves as a precursor of creatine with ergogenic potential. The ability to increase endogenous growth hormone makes arginine a preferred supplement for the improvement of physical performance. In the present study details about the pharmacological applications of arginine based on modern scientific investigations have been discussed. There are immense properties hidden in arginine that need to be explored using the scientific investigations to make it beneficial for the medicine and human health. More research is needed to evaluate the role of arginine supplementation on exercise performance and training adaptations in healthy and diseased populations before taking any conclusions.

  7. Pharmacological treatment of diabetic neuropathic pain. (United States)

    Smith, Howard S; Argoff, Charles E


    Neuropathic pain continues to be a difficult and challenging clinical issue to deal with effectively. Painful diabetic polyneuropathy is a complex pain condition that occurs with reasonable frequency in the population and it may be extremely difficult for clinicians to provide patients with effective analgesia. Chronic neuropathic pain may occur in approximately one of every four diabetic patients. The pain may be described as burning or a deep-seated ache with sporadic paroxysms of lancinating painful exacerbations. The pain is often constant, moderate to severe in intensity, usually primarily involves the feet and generally tends to worsen at night. Treatment may be multimodal but largely involves pharmacological approaches. Pharmacological therapeutic options include antidepressants (tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors), α2δ ligands and topical (5%) lidocaine patch. Other agents may be different antiepileptic drugs (carbamazepine, lamotrigine, topiramate), topical capsaicin, tramadol and other opioids. Progress continues with respect to understanding various mechanisms that may contribute to painful diabetic neuropathy. Agents that may hold some promise include neurotrophic factors, growth factors, immunomodulators, gene therapy and poly (adenosine diphosphate-ribose) polymerase inhibitors. It is hoped that in the future clinicians will be able to assess patient pathophysiology, which may help them to match optimal therapeutic agents to target individual patient aberrant mechanisms.

  8. Phytochemistry and Pharmacology of Berberis Species (United States)

    Mokhber-Dezfuli, Najmeh; Saeidnia, Soodabeh; Gohari, Ahmad Reza; Kurepaz-Mahmoodabadi, Mahdieh


    The genus Berberis (Berberidaceae) includes about 500 species worldwide, some of which are widely cultivated in the north-eastern regions of Iran. This genus consists of spiny deciduous evergreen shrubs, characterized by yellow wood and flowers. The cultivation of seedless barberry in South Khorasan goes back to two hundred years ago. Medicinal properties for all parts of these plants have been reported, including: Antimicrobial, antiemetic, antipyretic, antioxidant, anti-inflammatory, anti-arrhythmic, sedative, anti-cholinergic, cholagogic, anti-leishmaniasis, and anti-malaria. The main compounds found in various species of Berberis, are berberine and berbamine. Phytochemical analysis of various species of this genus revealed the presence of alkaloids, tannins, phenolic compounds, sterols and triterpenes. Although there are some review articles on Berberis vulgaris (as the most applied species), there is no review on the phytochemical and pharmacological activities of other well-known species of the genus Berberis. For this reason, the present review mainly focused on the diverse secondary metabolites of various species of this genus and the considerable pharmacological and biological activities together with a concise story of the botany and cultivation. PMID:24600191

  9. Pharmacological modulation of mitochondrial calcium homeostasis. (United States)

    Arduino, Daniela M; Perocchi, Fabiana


    Mitochondria are pivotal organelles in calcium (Ca 2+ ) handling and signalling, constituting intracellular checkpoints for numerous processes that are vital for cell life. Alterations in mitochondrial Ca 2+ homeostasis have been linked to a variety of pathological conditions and are critical in the aetiology of several human diseases. Efforts have been taken to harness mitochondrial Ca 2+ transport mechanisms for therapeutic intervention, but pharmacological compounds that direct and selectively modulate mitochondrial Ca 2+ homeostasis are currently lacking. New avenues have, however, emerged with the breakthrough discoveries on the genetic identification of the main players involved in mitochondrial Ca 2+ influx and efflux pathways and with recent hints towards a deep understanding of the function of these molecular systems. Here, we review the current advances in the understanding of the mechanisms and regulation of mitochondrial Ca 2+ homeostasis and its contribution to physiology and human disease. We also introduce and comment on the recent progress towards a systems-level pharmacological targeting of mitochondrial Ca 2+ homeostasis. © 2018 The Authors. The Journal of Physiology © 2018 The Physiological Society.

  10. Neuro-pharmacological functional MRI of epilepsy

    International Nuclear Information System (INIS)

    Kiriyama, Hideki; Makabe, Tetsuo; Tomita, Susumu; Omoto, Takashi; Asari, Shoji; Aihara, Hiroshi; Kinugasa, Kazushi; Nishimoto, Akira; Ito, Takahiko


    We studied patients with epilepsy by neuro-pharmacological functional MRI technique using diazepam. Five normal volunteers and 7 patients with epilepsy were investigated. MRI was performed by a 1.5 T unit (SIGNA Horizon, GE) using the following parameters: TR/TE 5000 msec/80 msec, FA 90 deg, FOV 200 mm, matrix 128 x 128, slice thickness 7 mm. We performed MRI scanning over 5 minutes (2 minutes before and 3 minutes after injection of diazepam) for each 1 session; we scanned 3 sessions for each patient at intervals of 5 minutes. The diazepam was injected rapidly from the antecubital vein. The dose of diazepam was 0.05 mg/kg/injection (total dose was 0.15 mg/kg). The data were analyzed statistically using t-test. Signal change after administration of diazepam was less than 1 to 2% in healthy volunteers. By contrast, in patient with epilepsy, the signal change was almost 3%, which was significantly greater than that of the normal area (p=0.01). The neuro-pharmacological functional MRI technique using diazepam might be a useful method to identify epileptic foci. (author)

  11. Harnessing Big Data for Systems Pharmacology. (United States)

    Xie, Lei; Draizen, Eli J; Bourne, Philip E


    Systems pharmacology aims to holistically understand mechanisms of drug actions to support drug discovery and clinical practice. Systems pharmacology modeling (SPM) is data driven. It integrates an exponentially growing amount of data at multiple scales (genetic, molecular, cellular, organismal, and environmental). The goal of SPM is to develop mechanistic or predictive multiscale models that are interpretable and actionable. The current explosions in genomics and other omics data, as well as the tremendous advances in big data technologies, have already enabled biologists to generate novel hypotheses and gain new knowledge through computational models of genome-wide, heterogeneous, and dynamic data sets. More work is needed to interpret and predict a drug response phenotype, which is dependent on many known and unknown factors. To gain a comprehensive understanding of drug actions, SPM requires close collaborations between domain experts from diverse fields and integration of heterogeneous models from biophysics, mathematics, statistics, machine learning, and semantic webs. This creates challenges in model management, model integration, model translation, and knowledge integration. In this review, we discuss several emergent issues in SPM and potential solutions using big data technology and analytics. The concurrent development of high-throughput techniques, cloud computing, data science, and the semantic web will likely allow SPM to be findable, accessible, interoperable, reusable, reliable, interpretable, and actionable.

  12. As easy as A, B and C: will A, B and C v. Ireland be Ireland's wake-up call for abortion rights? (United States)

    Staunton, Ciara


    This article examines the development of Ireland's abortion policy from 1861 to the present day. It explores the reasoning for this policy as well as the inherent problems with this policy. It examines in detail the A, B and C v. Ireland judgement and its impact, (if any) on Irish abortion law. Finally, it discusses the margin of appreciation doctrine used by the European Court of Human Rights in deciding cases of a moral nature.

  13. Neuropathic pain in people with cancer (part 2): pharmacological and non-pharmacological management. (United States)

    Taverner, Tarnia


    The aim of this paper is to provide an overview of the management of neuropathic pain associated with cancer and to provide helpful clinical advice for nurses working with patients who may have neuropathic pain. While cancer pain is a mixed-mechanism pain, this article will focus only on neuropathic pain management. The impact of neuropathic pain on patients' quality of life is great and while many patients recover from their cancer, a significant number continue to suffer from a neuropathic pain syndrome. Management of neuropathic pain is significantly different from management of nociceptive pain with respect to pharmacological and non-pharmacological strategies. Neuropathic pain is complex, and as such requires complex management using pharmacological as well as non-pharmacological approaches. Specific drugs for neuropathic pain may be effective for some patients, but not all; therefore, ongoing and comprehensive assessment and management are required. Furthermore, these patients may require trials of several drugs before they find one that works for them. It is important for nurses to understand neuropathic pain, its manifestation, impact on quality of life and management when nursing patients with neuropathic pain associated with cancer.

  14. Publication trends in Naunyn-Schmiedeberg's Archives of Pharmacology: focus on pharmacology in Egypt

    NARCIS (Netherlands)

    El-Mas, Mahmoud M.; El-Gowelli, Hanan M.; Michel, Martin C.


    In a previous analysis of the country of origin of papers published in Naunyn-Schmiedeberg's Archives of Pharmacology, a major shift toward contributions from emerging market countries, was noticed in comparison of 2010 to 2001 publications. Repeating such analysis for 2012 publications in the

  15. The bedrock electrical conductivity structure of Northern Ireland (United States)

    Beamish, David


    An airborne geophysical survey of the whole of Northern Ireland has provided over 4.8 M estimates of the bedrock conductivity over the wide range of geological formations present. This study investigates how such data can be used to provide additional knowledge in relation to existing digital geological map information. A by-product of the analysis is a simplification of the spatially aggregated information obtained in such surveys. The methodology used is a GIS-based attribution of the conductivity estimates using a lithological classification of the bedrock formations. A 1:250k geological classification of the data is performed leading to a 56 unit lithological and geostatistical analysis of the conductivity information. The central moments (medians) of the classified data are used to provide a new digital bedrock conductivity map of Northern Ireland with values ranging from 0.32 to 41.36 mS m-1. This baseline map of conductivities displays a strong correspondence with an existing 4 quadrant, chrono-geological description of Northern Ireland. Once defined, the baseline conductivity map allows departures from the norm to be assessed across each specific lithological unit. Bulk electrical conductivity is controlled by a number of petrophysical parameters and it is their variation that is assessed by the procedures employed. The igneous rocks are found to display the largest variability in conductivity values and many of the statistical distributions are multi-modal. A sequence of low-value modes in these data are associated with intrusives within volcanic complexes. These and much older Neoproterzoic rocks appear to represent very low porosity formations that may be the product of rapid cooling during emplacement. By way of contrast, extensive flood basalts (the Antrim lavas) record a well-defined and much higher median value (12.24 mS m-1) although they display complex spatial behaviour in detail. Sedimentary rocks appear to follow the broad behaviours anticipated

  16. Ensemble of regional climate model projections for Ireland (United States)

    Nolan, Paul; McGrath, Ray


    The method of Regional Climate Modelling (RCM) was employed to assess the impacts of a warming climate on the mid-21st-century climate of Ireland. The RCM simulations were run at high spatial resolution, up to 4 km, thus allowing a better evaluation of the local effects of climate change. Simulations were run for a reference period 1981-2000 and future period 2041-2060. Differences between the two periods provide a measure of climate change. To address the issue of uncertainty, a multi-model ensemble approach was employed. Specifically, the future climate of Ireland was simulated using three different RCMs, driven by four Global Climate Models (GCMs). To account for the uncertainty in future emissions, a number of SRES (B1, A1B, A2) and RCP (4.5, 8.5) emission scenarios were used to simulate the future climate. Through the ensemble approach, the uncertainty in the RCM projections can be partially quantified, thus providing a measure of confidence in the predictions. In addition, likelihood values can be assigned to the projections. The RCMs used in this work are the COnsortium for Small-scale MOdeling-Climate Limited-area Modelling (COSMO-CLM, versions 3 and 4) model and the Weather Research and Forecasting (WRF) model. The GCMs used are the Max Planck Institute's ECHAM5, the UK Met Office's HadGEM2-ES, the CGCM3.1 model from the Canadian Centre for Climate Modelling and the EC-Earth consortium GCM. The projections for mid-century indicate an increase of 1-1.6°C in mean annual temperatures, with the largest increases seen in the east of the country. Warming is enhanced for the extremes (i.e. hot or cold days), with the warmest 5% of daily maximum summer temperatures projected to increase by 0.7-2.6°C. The coldest 5% of night-time temperatures in winter are projected to rise by 1.1-3.1°C. Averaged over the whole country, the number of frost days is projected to decrease by over 50%. The projections indicate an average increase in the length of the growing season

  17. Radiation levels in milk and meat in Ireland after Chernobyl

    International Nuclear Information System (INIS)

    Dodd, Kevin; Hannan, John


    The island of Ireland has no nuclear energy industry and national power requirements are met by a combination of peat, gas and imported oil. We are acutely conscious of the proximity of nuclear installations on the West Coast of Britain and much effort is expended on monitoring the marine environment, particularly seaweed, fish and sediment. The Nuclear Energy Board is a government appointed body charged with the responsibility of regulating the use of radioactive materials in Irish hospitals laboratories and industry and with monitoring the radioactivity of food and in the air. It is very well recognised in Ireland that our reputation for clean food is crucial for our economic development and recent events have ensured increased emphasis on food monitoring for levels of radioactivity. Since the Chernobyl accident and with increased awareness of the vulnerability of our agriculture industry to airborne contamination, the resources of the Nuclear Energy Board has been stretched to the limit and there is an increased level of co-operative work with the physics department of the universities. University College Dublin Physics Department have monitored the milk used in the greater Dublin area since Chernobyl and it's in this area I wish to report. The sampling techniques were based on a random sampling of milk over a wide area and a detailed sampling on a daily basis of milk from the University Farm which is situated about 12 kilometers from Dublin, and have continued to date. Results: In the random milk supply the level of I131 and Cs137 rose from a background level of approx. 2-3bq/litre to approx. 300 bq/litre shortly after the plume reached Ireland on May 2nd 1986. One sample with 400 bq/litre I131 was observed. These levels fell rapidly over the next 2 weeks and settled down to levels of about 10-20 bq/litre. On the University Farm there was a difference between the levels in the morning and evening milk production as illustrated, probably due to the time

  18. A review of 4 norm industries in Ireland

    International Nuclear Information System (INIS)

    Organo, C.


    Full text: This presentation will review the progress achieved so far by the Irish national regulatory agency, the Radiological Protection Institut e of Ireland (R.P.I.I.) in the investigation of work activities where the presence of natural radiation sources (NORM) could lead to a significant increase in exposure to workers or members of the public which cannot be disregarded from the radiation protection point of view. Since the coming into force in Ma y 2000 of the Radiological Protection Act, 1991 (Ionising Radiation) Order, 2000 (S.I. No. 125 of 2000) which implements the Eu B.S.S. Directive 96/29/EURATOM, four major NORM industries currently active in Ireland have been investigated. According to the literature, they are all considered liable to involve work practices resulting in exposure to NORM. They include: the gas extraction and production industry, the peat- and coal-firing power generation industry and the bauxite/alumina refining industry. For the gas industry, monitoring of the radon concentrations in the extracted gas was carried out over a two-year period using Cr-39 passive alpha track detectors and sludge samples collected offshore in a separator were analysed by gamma spectrometry. Gamma dose rate measurements were also carried out at an onshore facility where disused equipment such as pipes is stored. The results will be presented and indicate that doses to workers or members of the public will not exceed the national regulatory limit of 1 mSv per year. The occupational dose received by any worker at the largest peat-fired power plant of the country was assessed. Preliminary results were presented at the IRPA 2004 conference (Organo et al. 2004) and have since been updated. An annual effective dose of less than 150 mSv was calculated taking into account external and internal pathways (gamma dose rate measurements, radon gas and peat dust inhalation) and plausible exposure scenarios. The use of coal fly ash in the manufacturing of building

  19. Pharmacology national board examinations: factors that may influence performance. (United States)

    Neidle, E A; Kahn, N


    Data from a survey of pharmacology courses in 60 dental schools were used to determine whether certain teaching variables affect performance in pharmacology National Board examinations. In addition, three-year class-averaged pharmacology scores and, rarely, one-year averaged scores were correlated with several admissions variables. While correlations between some admissions variables and pharmacology scores were quite good, the averaged pharmacology scores were not powerfully affected by course length, placement of the course in the curriculum, length of the curriculum, or the presence of a dentally trained pharmacologist in the department. It is suggested that other factors, related to the student and his capabilities, influence performance on National Boards. Dental pharmacology courses should be designed to given students the best possible exposure to an important basic science, not to make them perform well on National Boards, because student performance on National Boards may be independent of the nature of the didactic courses.

  20. Efficacy of Neurofeedback Versus Pharmacological Support in Subjects with ADHD. (United States)

    González-Castro, Paloma; Cueli, Marisol; Rodríguez, Celestino; García, Trinidad; Álvarez, Luis


    Behavioral training in neurofeedback has proven to be an essential complement to generalize the effects of pharmacological support in subjects who have attention deficit with hyperactivity disorder (ADHD). Therefore, this investigation attempts to analyze the efficacy of neurofeedback compared with pharmacological support and the combination of both. Participants were 131 students, classified into four groups: control (did not receive neurofeedback or pharmacological support), neurofeedback group, pharmacological support group, and combined group (neurofeedback + pharmacological support). Participants' executive control and cortical activation were assessed before and after treatment. Results indicate that the combined group obtained more benefits and that the neurofeedback group improved to a greater extent in executive control than the pharmacological support group. It is concluded that this kind of training may be an alternative to stimulate activation in subjects with ADHD.

  1. Radon in dwellings in selected areas of Ireland

    International Nuclear Information System (INIS)

    Madden, J.S.; Duffy, J.T.; Mackin, G.A.; Colgan, P.A.; McGarry, A.T.


    This report presents and interprets the results of surveys of domestic radon concentrations carried out by the Radiological Protection Institute of Ireland between 1989 and 1992. Data from low-density monitoring surveys in counties Mayo, Galway (including the Aran Island of Inis Mor) and Clare and in north Kerry, in addition to more detailed surveys in Moycullen and Salthill in Co. Galway and south Cork city are presented. The highest seasonally-corrected radon level found in any of the 1755 dwellings surveyed was 2399 Bq/m 3 . This is twelve times the national Reference Level of 200 Bq/m 3 , and corresponds to an annual radiation dose to occupants of the house of 60 mSv, three times the maximum dose which radiation workers are allowed to receive under internationally-accepted standards. Statistical evaluation of the data has allowed classification of 10 km grid square areas on the basis of the predicted proportion of houses in each grid square with radon levels in excess of the national Reference Level, 200 Bq/m 3 . The most affected areas occur in counties Mayo and Galway, and to a lesser extent in south-east Cork city. In county Galway six grid squares are predicted to have more than 20% of houses with radon concentrations in excess of 200 Bq/m 3 . In the most affected grid square 30% of houses are predicted to have radon concentrations in excess of this level. It is important that householders in these areas be strongly encouraged to have the radon levels in their houses measured in order to identify the individual houses in which remedial measures are required. The risk associated with longterm exposure to radon has been calculated using the latest risk factor recommended by the International Commission on Radiological Protection. For average residents exposed to indoor radon concentrations of 200 Bq/m 3 the estimated lifetime risk of premature death from lung cancer, due to radon, is about 2%. This risk is a significant addition to the prevailing lifetime

  2. Regulatory control of radiation sources and radioactive materials in Ireland

    International Nuclear Information System (INIS)

    McGarry, A.T.; Fenton, D.; O'Flaherty, T.


    The primary legislation governing safety in uses of ionizing radiation in Ireland is the Radiological Protection Act, 1991. This Act provided for the establishment in 1992 of the Radiological Protection Institute of Ireland, and gives the Institute the functions and powers which enable it to be the regulatory body for all matters relating to ionizing radiation. A Ministerial Order made under the Act in 2000 consolidates previous regulations and, in particular, provides for the implementation in Irish law of the 1996 European Union Directive which lays down basic safety standards for the protection of the health of workers and the general public against the dangers arising from ionizing radiation. Under the legislation, the custody, use and a number of other activities involving radioactive substances and irradiating apparatus require a licence issued by the Institute. Currently some 1260 licences are in force. Of these, some 850 are in respect of irradiating apparatus only and are issued principally to dentists and veterinary surgeons. The remaining licences involve sealed radiation sources and/or unsealed radioactive substances used in medicine, industry or education. A schedule attached to each licence fully lists the sealed sources to which the licence applies, and also the quantities of radioactive substances which may be acquired or held under the licence. It is an offence to dispose of, or otherwise relinquish possession of, any licensable material other than in accordance with terms and conditions of the licence. Disused sources are returned to the original supplier or, where this is not possible, stored under licence by the licensee who used them. Enforcement of the licensing provisions relies primarily on the programme of inspection of licensees, carried out by the Institute's inspectors. The Institute's Regulatory Service has a complement of four inspectors, one of whom is the Manager of the Service. The Manager reports to one of the Institute's Principal

  3. The detection of heterozygous familial hypercholesterolemia in Ireland.

    LENUS (Irish Health Repository)

    O'Kane, Maurice J


    Heterozygous familial hypercholesterolemia (HeFH) is an autosomal dominant condition with a population prevalence of 1 in 500, and is associated with significant cardiovascular morbidity and mortality. It may be caused by mutations in the low-density lipoprotein (LDL) receptor, apolipoprotein B100 (Apo B100), or proprotein convertase subtilisin\\/kexin type 9 (PCSK9) genes, with over 1,000 causative mutations described. Statin therapy in HeFH is considered effective and safe. Audit data suggest that approximately 80% of the putative HeFH population remains unidentified and, therefore, there is a need to develop a strategy for the identification of affected individuals so that early lipid-lowering treatment may be offered. There is good evidence showing the effectiveness and acceptability of HeFH screening programs in Europe. The authors describe a protocol for an all island approach to HeFH detection in the Republic of Ireland\\/Northern Ireland. Index cases will be identified by opportunistic screening using the Simon Broome, or Make Early Diagnosis to Prevent Early Death (MedPed) and World Health Organization (WHO) criteria. Patients identified as "definite," "probable," or "possible" HeFH criteria will be offered genetic testing. The authors expect causative mutations to be identified in approximately 80% of patients with "definite" HeFH but in only approximately 20% of patients with "possible" HeFH. Cascade screening will be undertaken in first-degree relatives of the index case using genetic testing (where a causative mutation has been identified), or otherwise using LDL cholesterol concentration. The establishment of a HeFH screening program on an all-island basis will require: expansion of the existing molecular genetics diagnostic services, the establishment of a cohort of nurses\\/genetic counselors, a HeFH database to support cascade testing, the development of a network of lipid clinics (in a primary or secondary care setting), and an educational

  4. Continuing Professional Development - Why Bother? Perceptions and Motivations of Teachers in Ireland (United States)

    McMillan, Dorothy J.; McConnell, Barbara; O'Sullivan, Helen


    In a larger study carried out by O'Sullivan "et al." to explore the perceptions and experiences of teachers in the Republic of Ireland and Northern Ireland who were engaged in continuing professional development (CPD), one of the significant findings to emerge was the key role of teacher motivation. The current study therefore focuses on…

  5. The first step towards a 100% renewable energy-system for Ireland

    DEFF Research Database (Denmark)

    Connolly, D.; Lund, Henrik; Mathiesen, Brian Vad


    , it is essential that Ireland begins to utilise its renewable resources more effectively. Therefore, this study presents the first step towards a 100% renewable energy-system for Ireland. The energy-system analysis tool used was EnergyPLAN, as it accounts for all sectors of the energy-system that need...

  6. Exposure to Community Violence and Political Socialization among Adolescents in Northern Ireland (United States)

    Shepherd, Linda


    This study evaluates the effects of adolescent exposure to cross-community violence, intense paramilitary operations, aggression, and intimidation in Northern Ireland. Using publicly available survey data gathered by agencies in Northern Ireland, the research examines the effects of exposure to political violence with focus upon the manner by…

  7. The Accelerating Campus Entrepreneurship (ACE) Initiative: Creating Entrepreneurial Graduates for Ireland (United States)

    Coleman, Maebh; Hamouda, Angela; Cormican, Kathryn


    According to the GEM Ireland Report (2009), those who have exposure to entrepreneurship education in Ireland have an increased propensity to start a new venture. The importance of entrepreneurial skills was picked up by the European Union which, in its Lisbon Strategy of March 2000, declared its objective of transforming Europe into the most…

  8. English as an Additional Language and Initial Teacher Education: Views and Experiences from Northern Ireland (United States)

    Skinner, Barbara


    This paper addresses training for teaching English as an Additional Language (EAL) at initial teacher education (ITE) level in Northern Ireland. This small-scale qualitative study describes 15 primary and post-primary teachers' perspectives on their preparation for teaching EAL in Northern Ireland. It explores reflections on EAL content in ITE…

  9. The Economic Impact of Higher Education Institutions in Ireland: Evidence from Disaggregated Input-Output Tables (United States)

    Zhang, Qiantao; Larkin, Charles; Lucey, Brian M.


    While there has been a long history of modelling the economic impact of higher education institutions (HEIs), little research has been undertaken in the context of Ireland. This paper provides, for the first time, a disaggregated input-output table for Ireland's higher education sector. The picture painted overall is a higher education sector that…

  10. Young adult type 1 diabetes care in the West of Ireland: an audit of hospital practice.

    LENUS (Irish Health Repository)

    Casey, R


    It is well recognised that management of young adults with type 1 diabetes (T1DM) poses difficult challenges for physicians and health care organisations as a whole. In Ireland and in particular the west of Ireland there has been little audit or research on young adults with T1DM and the services available to them.

  11. Self-rated health and quality of life in adults attending regional disability services in Ireland.

    LENUS (Irish Health Repository)

    Boland, Máirín C


    There is limited background information on self-rated health in people with disability in Ireland. This paper examines self-rated health scores and dimensions of functioning in people attending disability services and compares scores to the general population in Ireland, which has not been done before.

  12. Identity Dystopias, Empire Framing and Theoretical Hegemonies: Two Case Studies, India and Ireland (United States)

    Allender, Tim; O'Donoghue, Tom


    This article explores the connections between official contemporary identity formation and colonial pasts. Using the case studies of India and Ireland the article explores how different traditions of theorisation are powerful in these formations. India and Ireland were two colonial domains that had many linkages outside the ambit of the British.…

  13. The spider fauna of Scragh Bog in Co Westmeath, Ireland (Arachnida: Araneae)

    NARCIS (Netherlands)

    Helsdingen, van P.J.


    The spider fauna of Scragh Bog, a quacking bog in Co Westmeath, Ireland, was investigated for the first time. The presence of 53 species could be established, two of which are new to Ireland (Carorita limnaea (Crosby & Bishop), Porrhomma oblitum (O.P.-Cambridge)), while 30 represent new county

  14. Religious Diversity in Primary Schools: Reflections from the Republic of Ireland (United States)

    Faas, Daniel; Darmody, Merike; Sokolowska, Beata


    Growing secularisation of the population and the arrival of new culturally and religiously diverse migrants are posing new challenges to schools in the Republic of Ireland (Ireland). These challenges are particularly acute in Irish primary schools, the majority of which are under Catholic patronage. Recent changes have necessitated an extensive…

  15. Religion and Primary School Choice in Ireland: School Institutional Identities and Student Profile (United States)

    Darmody, Merike; Smyth, Emer


    Ireland's demographic profile has changed significantly in the past 20 years, being now characterised by increasing cultural, ethnic and religious diversity. However, primary schooling in Ireland has remained highly denominational, mostly Roman Catholic, in nature, with a small number of minority faith schools and multi-denominational schools.…

  16. Primary Geography in the Republic of Ireland: Practices, Issues and Possible Futures (United States)

    Pike, Susan


    In the Republic of Ireland, geography is recognized as an important subject for children to learn and all pupils take it throughout their primary school years. The current curriculum, the Primary School Curriculum-Geography, follows a tradition of innovative, child-centered geography curricula in Ireland. This article outlines the history of…

  17. Mental Health Law Reform: The Impact on Children and Young People in Northern Ireland (United States)

    Niwa, Laura


    The Bamford Review of Mental Health and Learning Disability (Northern Ireland) was established in October 2002 to examine all aspects of the law, policy and provisions that affect people with mental health needs or a learning disability in Northern Ireland. Its report "A Comprehensive Legislative Framework," which deals with the reform…

  18. Ten Years after Patten: Young People and Policing in Northern Ireland (United States)

    Byrne, Jonny; Jarman, Neil


    Through a comprehensive review of existing literature, this article documents young people's experiences of policing during the period of political transition and extensive reform of the structures of policing in Northern Ireland since the publication of the Independent Commission on Policing for Northern Ireland (The Patten Report) in 1999. The…

  19. Factors associated with duration of breastfeeding in ireland: potential areas for improvement.

    LENUS (Irish Health Repository)

    Tarrant, R C


    There is a need to comprehensively examine why mothers in Ireland discontinue breastfeeding early and to explore the factors influencing duration of breastfeeding during the first 6 months postpartum. Findings from this study provide valuable direction for future strategies and interventions aimed at increasing breastfeeding duration rates in Ireland.

  20. Phytochemistry, pharmacology and traditional uses of different Epilobium species (Onagraceae): a review. (United States)

    Granica, Sebastian; Piwowarski, Jakub P; Czerwińska, Monika E; Kiss, Anna K


    beneficial effect for this disorder, but the number of in vitro studies is not sufficient and the in vivo studies are not conclusive or too preliminary to draw a final conclusion about the efficacy of Epilobium preparations. More in vitro, in vivo and clinical studies to confirm this mode of action are strongly needed. Epilobium's extracts have also documented antioxidative and potential anti-inflammatory properties. Oenothein B can be considered as responsible for some of Epilobium pharmacological properties. Because of the lack of clinical data further studies are needed to provide an evidence base for traditional uses of plant materials belonging to the Epilobium genus. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  1. Physalis alkekengi L. var. franchetii (Mast.) Makino: An ethnomedical, phytochemical and pharmacological review. (United States)

    Li, Ai-Ling; Chen, Bang-Jiao; Li, Guo-Hui; Zhou, Ming-Xing; Li, Yan-Ru; Ren, Dong-Mei; Lou, Hong-Xiang; Wang, Xiao-Ning; Shen, Tao


    ingredients and structures, have been adequately verified. Modern pharmacological studies supported its uses in the traditional and folk medicines, however, the molecular mechanisms of purified compounds remained unclear and were worth of further exploration. Therefore, the researchers should be paid more attention to a better utilization of this plant. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

  2. Ethnobotany, phytochemistry, toxicology and pharmacological properties of Terminalia sericea Burch. ex DC. (Combretaceae) - A review. (United States)

    Mongalo, N I; McGaw, L J; Segapelo, T V; Finnie, J F; Van Staden, J


    The use of medicinal plants in the treatment of infections is ancient. A wide variety of ethnotherapeutic properties and pharmacological actions has been attributed to Terminalia sericea. Studies by various groups of investigators reveal that it is a multipurpose medicinal plant used mostly in the treatment of diarrhoea, sexually transmitted infections, skin rashes, tuberculosis and other infections. The current paper is aimed at providing an overview of the ethnomedicinal uses, toxicology, pharmacology and the phytochemistry of Terminalia sericea. Information was retrieved using various search engines, including Pubmed, Science Direct, Google Scholar, Scielo, SciFinder and Scopus. The key words used included Terminalia sericea, secondary metabolites, phytochemistry, biological activity, pharmacology, ethnobotanical survey, medicinal uses, safety, toxicology and other related words. Terminalia sericea is an important medicinal plant which possesses anti-HIV, anti-fungal, anti-bacterial, anticancer, lipolytic, wound healing, antiparasitic, anti-inflammatory and anti-oxidant activity, as the most valuable biological activities, thus lending pharmacological support to the plant's folkloric uses in indigenous medicine. Toxicologically, the extracts and isolated compounds from the plant species may have mild toxic effects. Phytochemically, the plant species possesses valuable compounds including triterpenes, alkaloids and flavonoids which may well contribute to its biological activity. Terminalia sericea contains secondary metabolites which are valuable in the treatment of a variety of human infections, including community acquired infections which may be prevalent in developing countries. The degree of toxicity reported in various extracts warrants further exploration of the cytotoxicity of the plant species, both against normal human cell lines and in vivo. Moreover, the acetylcholinesterase inhibitory and anti-inflammatory effects also need to be further

  3. Blended learning for reinforcing dental pharmacology in the clinical years: A qualitative analysis. (United States)

    Eachempati, Prashanti; Kiran Kumar, K S; Sumanth, K N


    Blended learning has become the method of choice in educational institutions because of its systematic integration of traditional classroom teaching and online components. This study aims to analyze student's reflection regarding blended learning in dental pharmacology. A cross-sectional study was conducted in Faculty of Dentistry, Melaka-Manipal Medical College among 3 rd and 4 th year BDS students. A total of 145 dental students, who consented, participate in the study. Students were divided into 14 groups. Nine online sessions followed by nine face-to-face discussions were held. Each session addressed topics related to oral lesions and orofacial pain with pharmacological applications. After each week, students were asked to reflect on blended learning. On completion of 9 weeks, reflections were collected and analyzed. Qualitative analysis was done using thematic analysis model suggested by Braun and Clarke. The four main themes were identified, namely, merits of blended learning, skill in writing prescription for oral diseases, dosages of drugs, and identification of strengths and weakness. In general, the participants had a positive feedback regarding blended learning. Students felt more confident in drug selection and prescription writing. They could recollect the doses better after the online and face-to-face sessions. Most interestingly, the students reflected that they are able to identify their strength and weakness after the blended learning sessions. Blended learning module was successfully implemented for reinforcing dental pharmacology. The results obtained in this study enable us to plan future comparative studies to know the effectiveness of blended learning in dental pharmacology.

  4. An observational study of clozapine induced sedation and its pharmacological management. (United States)

    Ramos Perdigués, Sònia; Sauras Quecuti, Rosa; Mané, Anna; Mann, Louisa; Mundell, Clare; Fernandez-Egea, Emilio


    Clozapine induced sedation is common but its management is unclear. We analyzed the factors associated with clozapine-induced sedation and the efficacy of common pharmacological strategies. We conducted a naturalistic observational study using two years electronic records of a cohort patients and three analyses: a cross sectional analysis of factors associated with total number of hours slept (as an objective proxy of sedation), and two prospective analyses of which factors were associated with changes in hours slept and the efficacy of two pharmacological strategies. 133 patients were included, of which 64.7% slept at least 9h daily. Among monotherapy patients (n=30), only norclozapine levels (r=.367, p=.03) correlated with hours slept. Using the prospective cohort (n=107), 42 patients decreased the number of hours slept, due to decreasing clozapine (40%) or augmenting with aripiprazole (36%). These two strategies were recommended to 22 (20.6%) and 23 (21.5%) subjects respectively but the majority (81.8% and 73.9%) did not reduce number of hours slept. Thus, pharmacological and non-pharmacological factors are involved in sedation. Norclozapine plasma levels correlated with total sleeping hours. Reducing clozapine and aripiprazole augmentation were associated to amelioration of sedation, although both strategies were effective only in a limited numbers of subjects. Copyright © 2015 Elsevier B.V. and ECNP. All rights reserved.

  5. Clozapine-resistant schizophrenia – non pharmacological augmentation methods

    Directory of Open Access Journals (Sweden)

    Gałaszkiewicz Joanna


    Full Text Available Clozapine is the drug of choice for drug-resistant schizophrenia, but despite its use, 30-40% patients fail to achieve satisfactory therapeutic effects. In such situations, augmentation attempts are made by both pharmacological and non-pharmacological methods. To date, most of the work has been devoted to pharmacological strategies, much less to augemantation of clozapine with electroconvulsive therapy (C+ECT, transcranial direct current stimulation (tDCS or transcranial magnetic stimulation (TMS.

  6. Quality of reporting statistics in two Indian pharmacology journals


    Jaykaran,; Yadav, Preeti


    Objective: To evaluate the reporting of the statistical methods in articles published in two Indian pharmacology journals. Materials and Methods: All original articles published since 2002 were downloaded from the journals′ (Indian Journal of Pharmacology (IJP) and Indian Journal of Physiology and Pharmacology (IJPP)) website. These articles were evaluated on the basis of appropriateness of descriptive statistics and inferential statistics. Descriptive statistics was evaluated on the basis of...

  7. A Review of Pharmacologic Treatment for Compulsive Buying Disorder


    Soares, Célia; Fernandes, Natália; Morgado, Pedro


    At present, no treatment recommendations can be made for compulsive buying disorder. Recent studies have found evidence for the efficacy of psychotherapeutic options, but less is known regarding the best pharmacologic treatment. The purpose of this review is to present and analyze the available published evidence on the pharmacological treatment of compulsive buying disorder. To achieve this, we conducted a review of studies focusing on the pharmacological treatment of compulsive buying by se...

  8. Play and play occupation: a survey of paediatric occupational therapy practice in Ireland

    Directory of Open Access Journals (Sweden)

    Alice Moore


    Full Text Available Purpose - Play occupation has been identified as an essential part of children’s lives, and it subsequently features in paediatric occupational therapy. However, few studies address the current place of play and play occupation in occupational therapy practice. This study aims to address this gap in knowledge by exploring paediatric occupational therapists’ perspectives on the place of play and play occupation in occupational therapy practice in Ireland. Design/methodology/approach - A cross-sectional online survey was conducted to gather data about the current use of play in the occupational therapy for children under 12 years. Convenience sampling and snowball recruitment techniques were used to recruit paediatric occupational therapists. Data were analysed using descriptive statistics and qualitative content analysis. Findings - In total, 65 therapists responded to the survey (estimated response rate, 32%. Results are organised into four sections: demographics and practice context, play assessment practices, use of play in practice and perceived barriers to play-centred practice. Respondents reported that they valued play as a childhood occupation. However, the survey findings identified that the primary focus was on play as a means to an end. Lack of education on play (research, theory and interventions and pressures in the workplace have been identified as barriers to play-centred practice. Research limitations/implications - Findings indicate that there is a mismatch between therapists valuing play as an occupation and how play is used in occupational therapy practice. Unless clarifications are made about play occupation as being different to skills acquisition in childhood, play occupation will continue to get overlooked as an authentic concern of occupation-centred practice. Thus, play as occupation deserves further attention from educators, researchers and practitioners as a means of strengthening occupation-centred practice, in

  9. The burden of motorcycle-related neuro-trauma in Ireland and associated helmet usage.

    LENUS (Irish Health Repository)

    Murphy, R K J


    Motorcycles represent less than 2% of the licensed vehicles but motorcyclists account for 12% of road deaths in Ireland. The British Road Safety Authority has introduced the Sharp programme, which hopes to save 50 lives in the U.K. each year alone by helping riders to choose the best-fitting and safest helmets. We evaluated the pattern of head injuries sustained by motorcyclists referred to the two neurosurgical centres Beaumont Hospital and Cork University Hospital in Ireland and ascertained if the new SHARP guidelines could be of benefit in reducing the burden of motorcycle related neurotrauma and disability in Ireland. Despite Ireland having mandatory helmet laws almost a quarter of our motorcyclists with traumatic brain injury were unhelmeted. A significant reduction in mortality and morbidity is predicted if all motorcyclists in Ireland were to wear helmets that satisfied the SHARP criteria.

  10. Artificial radioactivity on the coasts of Northern Ireland

    International Nuclear Information System (INIS)

    Garland, J.A.; McKay, W.A.; Burton, P.J.; Cambray, R.S.


    In Northern Ireland, measurements of artificial radioactivity have been made in inshore seawater, beach sand and mud, sea spray, the air and material deposited from the air, and in coastal soil. The objective was to determine the levels in the coastal environment and also to assess the magnitude of transport of radioactivity from sea to land in sea spray. The results would provide a basis for the development of a model describing sea to land transfer, and allowing the resulting population exposure to be assessed. The results showed the presence of plutonium isotopes, 241 Am and 137 Cs in some samples of each of the media measured, but concentrations were low in all cases. Large variation in the concentrations in seawater and beach sediment were attributed to variations in dispersion and in the characteristics of the sediment. Sea to land transfer of actinides was detected in samples of sea spray and in air and deposition measurements. Only at some sites on the east coast could the resulting accumulation in soil close to the beach be distinguished from fallout. Following May 1986 137 Cs from Chernobyl could be detected in air and in atmospheric deposition. A preliminary assessment of the exposure of the population to the actinides and 137 Cs in all the media showed that the resulting dose is a small fraction of the recognised limit. (author)

  11. Research priorities for nursing and midwifery in Southern Ireland. (United States)

    McCarthy, G; Savage, E; Lehane, E


    To identify research priorities for nursing and midwifery in the Southern Health Board area in Ireland for the immediate and long term. Ten focus groups were conducted over a 2-month period with 70 nurses and midwives working in clinical, managerial and educational roles participating. Based on focus group findings and a literature review a multi-item Likert type questionnaire was constructed and administered to 520 nurses and midwives (response rate 95%n=494). Research priorities were identified as: (1) impact of staff shortages on retention of RNs/RM's (80%); (2) quality of life of chronically ill patients (76%); (3) stress and bullying in the workplace (76%); (4) assessment and management of pain (75%); (5) skill mix and staff burnout (73%); (6) cardio-pulmonary resuscitation decision making (72%); (7) coordination of care between hospital and primary care settings (69%); (8) medication errors (67%); and (9) promoting healthy lifestyles (64%). Respondents also indicated that these priorities warranted immediate attention. Implications for practice include the need for: (1) emphasis on quality pain control; (2) recognition and exploration of the ethical issues relating to resuscitation; and (3) management of the context within which clinical care is given.

  12. Paediatric stoma care nursing in the UK and Ireland. (United States)

    Waller, Marie

    Improving quality of care and developing and maintaining high standards of care are issues that are high on the NHS, nursing, and paediatric care agendas. Stoma formation will have an impact on the wellbeing and lifestyle of the person and their family, whatever the person's age. The specialty of stoma care nursing in the UK and Ireland is well established. However, the sub-specialty of paediatric stoma care nursing is much smaller in its 'membership' and its client group. There are differences in the needs of, and the associated care of, paediatric stoma patients even within this overall patient group. Paediatric stoma care nurses are in an ideal position to increase awareness about the specialty and improve standards of nursing care for neonates, children, adolescents and their families. However, until the establishment of the Paediatric Stoma Nurse Group (PSNG) in 2005, this 'position' had not being utilized. This article discusses the ongoing work of the PSNG to devise standards of paediatric stoma care nursing, best practice guidelines, relevant patient/parental information and establish itself as a valuable, proactive and independent forum for all healthcare professionals involved in the care of children with stomas.

  13. Exploring Childcare: A North West of Ireland Study

    Directory of Open Access Journals (Sweden)

    Maureen O'Hara


    Full Text Available This study sought to explore and examine if the provision of full day care improves the quality of life for children and their parents. There are now 60.8% of women employed in the workforce (CSO, 2008. This means many changes for children, parents and families. Twenty-seven childcare managers in the north west of Ireland were interviewed. Also, 325 questionnaires were completed by working parents. Babies as young as four months are being cared for in childcare facilities from 6.45am until 6pm daily, five days per week. Some children are spending up to 11 hours per day in childcare facilities. The study concluded that full day care can have both positive and negative effects for children. Childcare facilities are providing good quality childcare encompassing various services. Parents are finding it difficult to manage work life balance. Health dominated quality of life issues. Two hundred and thirty five (235 (73% parents reported being stressed. The study also found that 315 (97% working parents feel that the government is not doing enough to support working parents. On a positive note, 241 (74% parents said they are happy in general with the quality of life for them, their family and their children.

  14. Assessment and Characterisation of Ireland's Green Tides (Ulva Species). (United States)

    Wan, Alex H L; Wilkes, Robert J; Heesch, Svenja; Bermejo, Ricardo; Johnson, Mark P; Morrison, Liam


    Enrichment of nutrients and metals in seawater associated with anthropogenic activities can threaten aquatic ecosystems. Consequently, nutrient and metal concentrations are parameters used to define water quality. The European Union's Water Framework Directive (WFD) goes further than a contaminant-based approach and utilises indices to assess the Ecological Status (ES) of transitional water bodies (e.g. estuaries and lagoons). One assessment is based upon the abundance of opportunistic Ulva species, as an indication of eutrophication. The objective of this study was to characterise Ireland's Ulva blooms through the use of WFD assessment, metal concentrations and taxonomic identity. Furthermore, the study assessed whether the ecological assessment is related to the metal composition in the Ulva. WFD algal bloom assessment revealed that the largest surveyed blooms had an estimated biomass of 2164 metric tonnes (w/w). DNA sequences identified biomass from all locations as Ulva rigida, with the exception of New Quay, which was Ulva rotundata. Some blooms contained significant amounts of As, Cu, Cr, Pb and Sn. The results showed that all metal concentrations had a negative relationship (except Se) with the Ecological Quality Ratio (EQR). However, only in the case of Mn were these differences significant (p = 0.038). Overall, the metal composition and concentrations found in Ulva were site dependent, and not clearly related to the ES. Nevertheless, sites with a moderate or poor ES had a higher variability in the metals levels than in estuaries with a high ES.

  15. Babesias of red deer (Cervus elaphus in Ireland

    Directory of Open Access Journals (Sweden)

    Zintl Annetta


    Full Text Available Abstract Blood samples were obtained from 38 wild red deer (Cervus elaphus at two sites in Ireland and subjected to PCR analysis of the 18S rRNA gene followed by sequencing. Two fragments of the 18S rRNA gene were generated by two different PCR protocols and subsequent sequencing suggested that at least six of the deer were infected by a babesia that, in those loci, is indistinguishable from Babesia divergens, an important tick-borne pathogen of cattle and of zoonotic significance. Additionally, a B. odocoilei-like parasite was detected in three samples and a babesia that did not match any sequences in the GenBank database was found in five samples. Neither B. capreoli nor B. venatorum (EU1 were found. There have been several reports of B. divergens occurring in deer species, including red deer, roe deer (Capreolus capreolus and reindeer (Rangifer tarandus. However, in view of recent re-sequencing of bovine-origin samples deposited previously in GenBank, it is unlikely that any of these sequences from deer are B. divergens. The present study describes the only deer piroplasm detected so far that shows complete identity with B. divergens, in just over half of the 18S rRNA gene. The entire gene of this deer parasite should be analysed and transmission experiments undertaken before the infectivity of B. divergens for red deer can be confirmed.

  16. The energy programme in Great Britain and Northern Ireland

    International Nuclear Information System (INIS)

    Fells, I.


    Great Britain and Northern Ireland are for the time being, thanks to North Sea oil and gas, self-supporting in energy supply (coal 36%, oil 34%, gas 23%, nuclear 6%, hydraulic 1%) a situation which may continue for 2 or 3 decades. By AD2101 it is expected that nuclear generation, including the use of fast-breeder reactors, will supply 50% of electrical energy (currently 14%). The article discusses primary energy sources with tabulated statistics from Government information, and mentions the 2000MW link with France now under construction. Among alternative resources the more promising appear to be wind generation and a Severn barrage; the latter could provide 2000-4000MW. Water power has very small potential but pumped storage (Dinorwic 1700MW) is important. The prospects for wave energy are poor. Acid rain is seen as a growing problem. Various ideas for energy saving are discussed and the present policy of examining the future of energy consumption in terms of 'scenarios' is briefly described. All of these include an increase in the proportion of electrical energy in the total consumption. (C.J.O.G.)

  17. Alcohol attributable hospitalisations and costs in Ireland, 2000-2004.

    LENUS (Irish Health Repository)

    Martin, J


    The aim of this study was to calculate the number and costs of hospital bed-days due to alcohol use in Ireland over the five year period 2000 to 2004. Age and sex specific Irish alcohol-attributable-fractions (AAFs) were developed by combining international risk estimates with Irish consumption data where available; where not available international AAFs were used. These were applied to national datasets to count the number and costs of bed-days wholly caused and prevented by alcohol and that proportion of bed-days that were partially caused and prevented by alcohol. Between 2000 and 2004, alcohol was estimated to have caused 3,428,973 (10.3%) and prevented 529,239 (1.6%) of hospital bed-days, giving a net number of bed-days due to alcohol of 2,899,734 (8.7%). Over this period the hospital inpatient costs attributed to the negative effects of alcohol were 953,126,381 euros, the costs attributed to hospitalisations prevented were 147,968,164 euros; giving net costs of alcohol-attributed bed-days of 805,158,217 euros. Chronic conditions accounted for 3,262,408 (95%) hospital bed-days due to the harmful effects of alcohol. Conditions not wholly due to alcohol accounted for 2,297,412 (67%) hospital bed-days due to the harmful effects of alcohol. The negative impacts of alcohol were greater than previously thought and spread across the whole population.

  18. Radiocaesium fallout in Ireland from the Chernobyl accident

    International Nuclear Information System (INIS)

    McAulay, I.R.; Moran, D.


    This paper presents a radiocaesium deposition pattern over Ireland resulting from the Chernobyl accident. Contaminated grassland soils from over 110 sites were analysed using gamma ray spectrometry. 134 Cs, 137 Cs and 40 K were measured in all samples. The Chernobyl 137 Cs was identified using an initial Chernobyl fallout 137 Cs to 134 Cs ratio of 1.90. The results show a mean deposition level of 3.2 kBq m -2 of 137 Cs due to Chernobyl. The range of deposition was from 0.3 to 14.2 kBq m -2 . The distribution pattern is presented both on a National grid sub-zone basis and a higher resolution shaded map. A similarly shaded map shows the rainfall levels responsible for most of the washout. It is pointed out that some areas on both east and west coasts with maximum rainfall did not have maximum caesium deposition. In other areas a better correlation between rainfall and caesium deposition exists. A mean figure for the pre-Chernobyl 137 Cs in surface soil is provided. (author)

  19. Benchmarking the financial performance of local councils in Ireland

    Directory of Open Access Journals (Sweden)

    Robbins Geraldine


    Full Text Available It was over a quarter of a century ago that information from the financial statements was used to benchmark the efficiency and effectiveness of local government in the US. With the global adoption of New Public Management ideas, benchmarking practice spread to the public sector and has been employed to drive reforms aimed at improving performance and, ultimately, service delivery and local outcomes. The manner in which local authorities in OECD countries compare and benchmark their performance varies widely. The methodology developed in this paper to rate the relative financial performance of Irish city and county councils is adapted from an earlier assessment tool used to measure the financial condition of small cities in the US. Using our financial performance framework and the financial data in the audited annual financial statements of Irish local councils, we calculate composite scores for each of the thirty-four local authorities for the years 2007–13. This paper contributes composite scores that measure the relative financial performance of local councils in Ireland, as well as a full set of yearly results for a seven-year period in which local governments witnessed significant changes in their financial health. The benchmarking exercise is useful in highlighting those councils that, in relative financial performance terms, are the best/worst performers.

  20. Radiological Protection Institute of Ireland Strategic Plan 2011 to 2013

    International Nuclear Information System (INIS)


    The RPII's remit is very broad. It includes three main pillars; regulating all uses of ionising radiation; assessing people's exposure to ionising radiation; advising Government and the public on the prevention of unnecessary exposure. This plan builds on the previous Strategic Plan for 2008 to 2012 and sets out clearly the developments we expect over the planning period, the strategic priorities we are commiting to, along with a clear description of how we will address these priorities. Four key strategic priorities and associated objectives have been developed for this period. The key themes underpinning all four strategic priorities are public value, transparency, communication and sustainability. The priorities are; to provide the expertise, technical capability and information essential to the protection of the Irish population and the environment; to regulate the safe and secure use of ionising radiation in Ireland in a sustainable and transparent manner; to work in partnership with others to implement national radiological protection initiatives; to deliver value to the public in everything we do

  1. High Radon Areas and lung cancer prevalence: Evidence from Ireland. (United States)

    Dempsey, Seraphim; Lyons, Seán; Nolan, Anne


    This paper examined the relationship between radon risk and lung cancer prevalence using a novel dataset combining spatially-coded survey data with a radon risk map. A logit model was employed to test for significant associations between a high risk of indoor radon and lung cancer prevalence using data on 5590 people aged 50+ from The Irish Longitudinal Study on Ageing (TILDA) and radon risk data from Ireland's Environmental Protection Agency (EPA). The use of data at the individual level allowed a wide range of potentially confounding factors (such as smoking) to be included. Results indicate that those who lived in an area in which 10%-20% of households were above the national reference level (200 Bq/m 3 ) were 2.9-3.1 times more likely to report a lung cancer diagnosis relative to those who lived in areas in which less than 1% of households were above the national reference level. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Determining the cost of genital warts: a study from Ireland.

    LENUS (Irish Health Repository)

    Dee, A


    OBJECTIVES: To determine the average cost of a case of genital warts, for both males and females, with a view to informing the current debate as to which Human papillomavirus vaccine would have maximum cost-effectiveness in the Irish population. METHODS: Contact time between patients and healthcare professionals was prospectively measured at five genitourinary medicine clinics in the south-west of Ireland, over a period of 3 weeks. By identifying all those with genital warts, it was possible to calculate the proportion of total time taken by patients with this condition, and from this to calculate a cost per incident case, by gender. RESULTS: A total of 25.5% of attendances were for genital warts, and these patients used 26.2% of total clinic time (CI 25.4 to 27.0%). The average cost calculated for genital warts was 335 euros per incident case, and by gender 300 euros per male case and 366 euros per female case. CONCLUSIONS: There are considerable costs associated with the treatment of genital warts, with female cases representing a higher cost than males. By vaccinating with the quadrivalent HPV vaccine, there are significant savings to be made.

  3. Flood vulnerability of critical infrastructure in Cork, Ireland

    Directory of Open Access Journals (Sweden)

    de Bruijn Karin M.


    Full Text Available Recent flood events in Ireland and particularly in County Cork have caused significant disruption to health service provisions, interruption of water and power supplies, and damage to roads and other transportation infrastructure, affecting the lives of hundreds of thousands of people over a prolonged period of weeks. These events clearly reveal- the vulnerability of the critical infrastructure to flooding and the dependence of society on critical infrastructure. In order to reduce the flood vulnerability and increase the resilience of the critical infrastructure networks in the future, detailed evidence-based analysis and assessment is essential. To this end a case study has been carried out on Cork City which analyses this vulnerability as it was in 2009, and as it is currently, and identifies adaptation options to reduce the future vulnerability of critical infrastructure to flooding and to build a more resilient society. This paper describes the storyline approach and CIrcle tool and their application to Cork City which focused on the analysis of the flood vulnerability of critical infrastructure and the impacts of failure of the infrastructure for other critical functions and on society.

  4. Public practice regarding disposal of unused medicines in Ireland. (United States)

    Vellinga, Akke; Cormican, Sarah; Driscoll, Jacqueline; Furey, Michelle; O'Sullivan, Mai; Cormican, Martin


    Over recent years, a global increase in the use of pharmaceutical products has been observed. EU directives state that "Member states shall ensure that appropriate collection systems are in place for medicinal products that are unused or have expired" (Directive 2001/83/EC and Directive 2004/27/EC). There is no published data on how people in Ireland dispose of unused medicines; therefore the purpose of this study is to establish baseline information on storage and disposal of medicines. Data was collected over two 2-week periods a year apart. People in the streets of Galway and Cork were approached randomly and invited to participate by filling out a questionnaire. The questionnaire was completed by 398 individuals (207 in Galway and 191 in Cork). Unused medicines were kept in the home by 88% of the respondents. The most cited reason for keeping unused medicines was "in case they are needed later" (68%). Of the respondents who had disposed of medicine in the past, 72% had done so inappropriately. Environmentally inappropriate disposal methods were through general waste disposal and via the sewage system. Interestingly, of the people who had received advice on disposal practices from a healthcare professional, 75% disposed of their medicine appropriately. There is little awareness among members of the public regarding appropriate ways to dispose of unused medicines. Our findings suggest that effective communication and established protocols will promote appropriate disposal practices. Copyright © 2014 Elsevier B.V. All rights reserved.

  5. Courts, legislators and human embryo research: lessons from Ireland. (United States)

    Binchy, William


    When it comes to the matter of human embryo research law plays a crucial role in its development by helping to set the boundaries of what may be done, the sanctions for acting outside those boundaries and the rights and responsibilities of key parties. Nevertheless, the philosophical challenges raised by human embryo research, even with the best will of all concerned, may prove too great for satisfactory resolution through the legal process. Taking as its focus the position of Ireland, this paper explores the distinctive constitutional approach taken on this issue and addresses the difficulty of translating sound philosophy into judicial decrees and the difficulty of establishing expert commissions to make law reform proposals on matters of profound normative controversy. It concludes that the Irish experience does have useful lessons for those in other countries who are concerned with the legal approach to research on human embryos and points to the desirability of a diversity of normative positions in order to enrich the quality of the analysis so as to encourage more informed debate in society.

  6. Victim support services in England, Wales and Northern Ireland

    Directory of Open Access Journals (Sweden)

    Ćopić Sanja M.


    Full Text Available In the paper, authors tried to present activities of one of the oldest European Victim Support Services - Victim Support for England, Wales and Northern Ireland. During 1970s, through practice and research projects, the need for recognizing the physical and psychological status of victims after the crime was committed, as well as the need of providing them with the (informal assistance and support were noticed. That has resulted in establishing numerous of local victim support services (schemes, which united in the National Association of the Victim Support Services in 1979. Significant support was given to the Service in 1980s through the recommendations of the Council of Europe on the assistance for victims of crime and prevention of victimization through direct support given to the victim immediately after the incident, including protection and safety, medical, mental, social and financial support, as well as providing the victim with information on his/her rights, support during the criminal proceeding, assistance in getting compensation etc. Organization and structure of the service, referral system, code of practice and two main programs: Victim Service and Witness Service are reviewed in the paper.

  7. An assessment of indoor radon exposure in Ireland

    International Nuclear Information System (INIS)

    McLaughlin, J.P.


    The results of measurements of indoor radon in over 700 dwellings chosen at ''random'' throughout the Republic of Ireland are presented. The median value of radon in these dwellings was found to be 37 Bq/m 3 (1 pCi/1). The distribution of indoor radon concentration appears to be approximately log-normal with about 2% of the dwellings surveyed having concentrations greater than 400 Bq/m 3 . High radon values were generally found to be more common in western and southern regions of the country than in the more densely populated eastern seabord. Using dose conversion factors in keeping with recent developments in lung dosimetry the median effective dose equivalent to occupants arising from the inhalation of radon daughters in the dwellings surveyed is estimated to be about 1.8 mSv per year. On the same basis for dwellings with indoor radon above 400 Bq/m 3 the continuous effective dose equivalent is estimated to be in excess of 20 mSv per year

  8. Network-based Approaches in Pharmacology. (United States)

    Boezio, Baptiste; Audouze, Karine; Ducrot, Pierre; Taboureau, Olivier


    In drug discovery, network-based approaches are expected to spotlight our understanding of drug action across multiple layers of information. On one hand, network pharmacology considers the drug response in the context of a cellular or phenotypic network. On the other hand, a chemical-based network is a promising alternative for characterizing the chemical space. Both can provide complementary support for the development of rational drug design and better knowledge of the mechanisms underlying the multiple actions of drugs. Recent progress in both concepts is discussed here. In addition, a network-based approach using drug-target-therapy data is introduced as an example. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Pharmacological management of spasticity in multiple sclerosis

    DEFF Research Database (Denmark)

    Otero-Romero, Susana; Sastre-Garriga, Jaume; Comi, Giancarlo


    Background and objectives: Treatment of spasticity poses a major challenge given the complex clinical presentation and variable efficacy and safety profiles of available drugs. We present a systematic review of the pharmacological treatment of spasticity in multiple sclerosis (MS) patients. Methods...... improvement is seen with the previous drugs. Nabiximols has a positive effect when used as add-on therapy in patients with poor response and/or tolerance to first-line oral treatments. Despite limited evidence, intrathecal baclofen and intrathecal phenol show a positive effect in severe spasticity...... and suboptimal response to oral drugs. Conclusion: The available studies on spasticity treatment offer some insight to guide clinical practice but are of variable methodological quality. Large, well-designed trials are needed to confirm the effectiveness of antispasticity agents and to produce evidence...

  10. Radioimmunoassay in basic and clinical pharmacology

    International Nuclear Information System (INIS)

    Patrono, C.; Peskar, B.A.


    The subject of the book is the development, validation and application of radioimmunoassay (RIA) techniques for the measurement of a variety of substances in animal and human body fluids. The book discusses methodological and conceptual issues related to the main classes of mediators of drug action and to drugs themselves, as assayed by this particular analytical technique. A number of introductory chapters provide basic information concerning production and characterization of antibodies, labeling techniques, statistical aspects and validation criteria, insight into problems related to the development and validation of RIA for the newly discovered mediator(s). In the following chapters, the emphasis is placed on the technical details relevant to each class of compounds and on specific aspects of their applications to basic and/or clinical pharmacological studies. New developments in this area, such as monoclonal antibodies and non-radioactive labeling techniques, are also covered

  11. Pharmacological Aspects of Vipera xantina palestinae Venom (United States)

    Momic, Tatjana; Arlinghaus, Franziska T.; Arien-Zakay, Hadar; Katzhendler, Jeoshua; Eble, Johannes A.; Marcinkiewicz, Cezary; Lazarovici, Philip


    In Israel, Vipera xantina palestinae (V.x.p.) is the most common venomous snake, accounting for several hundred cases of envenomation in humans and domestic animals every year, with a mortality rate of 0.5 to 2%. In this review we will briefly address the research developments relevant to our present understanding of the structure and function of V.x.p. venom with emphasis on venom disintegrins. Venom proteomics indicated the presence of four families of pharmacologically active compounds: (i) neurotoxins; (ii) hemorrhagins; (iii) angioneurin growth factors; and (iv) different types of integrin inhibitors. Viperistatin, a α1β1selective KTS disintegrin and VP12, a α2β1 selective C-type lectin were discovered. These snake venom proteins represent promising tools for research and development of novel collagen receptor selective drugs. These discoveries are also relevant for future improvement of antivenom therapy towards V.x.p. envenomation. PMID:22174978

  12. Safety pharmacology--current and emerging concepts. (United States)

    Hamdam, Junnat; Sethu, Swaminathan; Smith, Trevor; Alfirevic, Ana; Alhaidari, Mohammad; Atkinson, Jeffrey; Ayala, Mimieveshiofuo; Box, Helen; Cross, Michael; Delaunois, Annie; Dermody, Ailsa; Govindappa, Karthik; Guillon, Jean-Michel; Jenkins, Rosalind; Kenna, Gerry; Lemmer, Björn; Meecham, Ken; Olayanju, Adedamola; Pestel, Sabine; Rothfuss, Andreas; Sidaway, James; Sison-Young, Rowena; Smith, Emma; Stebbings, Richard; Tingle, Yulia; Valentin, Jean-Pierre; Williams, Awel; Williams, Dominic; Park, Kevin; Goldring, Christopher


    Safety pharmacology (SP) is an essential part of the drug development process that aims to identify and predict adverse effects prior to clinical trials. SP studies are described in the International Conference on Harmonisation (ICH) S7A and S7B guidelines. The core battery and supplemental SP studies evaluate effects of a new chemical entity (NCE) at both anticipated therapeutic and supra-therapeutic exposures on major organ systems, including cardiovascular, central nervous, respiratory, renal and gastrointestinal. This review outlines the current practices and emerging concepts in SP studies including frontloading, parallel assessment of core battery studies, use of non-standard species, biomarkers, and combining toxicology and SP assessments. Integration of the newer approaches to routine SP studies may significantly enhance the scope of SP by refining and providing mechanistic insight to potential adverse effects associated with test compounds. Copyright © 2013 Elsevier Inc. All rights reserved.

  13. Pharmacological Strategies to Retard Cardiovascular Aging (United States)

    Alfaras, Irene; Di Germanio, Clara; Bernier, Michel; Csiszar, Anna; Ungvari, Zoltan; Lakatta, Edward G.; de Cabo, Rafael


    Aging is the major risk factor for cardiovascular diseases (CVD), which are the leading cause of death in the United States. Traditionally, the effort to prevent CVD has been focused on addressing the conventional risk factors, including hypertension, hyperglycemia, hypercholesterolemia, and high circulating levels of triglycerides. However, recent preclinical studies have identified new approaches to combat CVD. Calorie restriction has been reproducibly shown to prolong lifespan in various experimental model animals. This has led to the development of calorie restriction mimetics and other pharmacological interventions capable to delay age-related diseases. In this review, we will address the mechanistic effects of aging per se on the cardiovascular system and focus on the pro-longevity benefits of various therapeutic strategies that support cardiovascular health. PMID:27174954

  14. Pharmacologic Implications of Marijuana Use During Pregnancy. (United States)

    Fantasia, Heidi Collins

    Marijuana is the most commonly used recreational drug in the United States, including among women of childbearing age and women who are pregnant. Changing legal statutes that allow for the use of medical marijuana and the decriminalization of marijuana for personal use reflect more permissive societal views on the use of this drug. Active compounds in marijuana cross the placenta rapidly and are excreted in breast milk. Results of studies of the effects of marijuana on a developing fetus and neonate are conflicting, but researchers have identified chronic marijuana exposure as a risk factor for preterm birth and small-for-gestational-age infants. This article reviews the pharmacology of marijuana and discusses implications for nurses who work with women of childbearing age. © 2017 AWHONN, the Association of Women’s Health, Obstetric and Neonatal Nurses.

  15. Anthraquinones As Pharmacological Tools and Drugs. (United States)

    Malik, Enas M; Müller, Christa E


    Anthraquinones (9,10-dioxoanthracenes) constitute an important class of natural and synthetic compounds with a wide range of applications. Besides their utilization as colorants, anthraquinone derivatives have been used since centuries for medical applications, for example, as laxatives and antimicrobial and antiinflammatory agents. Current therapeutic indications include constipation, arthritis, multiple sclerosis, and cancer. Moreover, biologically active anthraquinones derived from Reactive Blue 2 have been utilized as valuable tool compounds for biochemical and pharmacological studies. They may serve as lead structures for the development of future drugs. However, the presence of the quinone moiety in the structure of anthraquinones raises safety concerns, and anthraquinone laxatives have therefore been under critical reassessment. This review article provides an overview of the chemistry, biology, and toxicology of anthraquinones focusing on their application as drugs. © 2016 Wiley Periodicals, Inc.

  16. Targeting HIV latency: pharmacologic strategies toward eradication (United States)

    Xing, Sifei; Siliciano, Robert F.


    The latent reservoir for HIV-1 in resting CD4+ T cells remains a major barrier to HIV-1 eradication, even though highly active antiretroviral therapy (HAART) can successfully reduce plasma HIV-1 levels to below the detection limit of clinical assays and reverse disease progression. Proposed eradication strategies involve reactivation of this latent reservoir. Multiple mechanisms are believed to be involved in maintaining HIV-1 latency, mostly through suppression of transcription. These include cytoplasmic sequestration of host transcription factors and epigenetic modifications such as histone deacetylation, histone methylation and DNA methylation. Therefore, strategies targeting these mechanisms have been explored for reactivation of the latent reservoir. In this review, we discuss current pharmacological approaches toward eradication, focusing on small molecule latency-reversing agents, their mechanisms, advantages and limitations. PMID:23270785

  17. Pharmacological Needs of Nurses: Short Communication

    Directory of Open Access Journals (Sweden)

    Leila Nazari


    Full Text Available Background and objectives : This study was carried out to determine the most commonly used drugs in health centers. By identifying common medications, pharmacological educational needs of nurses gets clear and officials can provide nurses specific relevant training about common drugs. Material and Methods: In this descriptive report, the hospitals’ pharmacies were asked to name ten of the most widely used drugs in the past 6 months. The obtained data were analyzed by SPSS 13 software using descriptive tests. Results: Gastrointestinal drugs and antibiotics in all centers and oxytocin in obstetrics and gynecological centers were the most commonly used drugs. Conclusion: Due to the important and dangerous side-effects of these common medications, renewing nurses’ information in this field is required. ​

  18. Clinical Pharmacology and Pharmacokinetics of Levetiracetam

    Directory of Open Access Journals (Sweden)

    Chanin Clark Wright


    Full Text Available Status epilepticus and acute repetitive seizures still pose a management challenge despite the recent advances in the field of epilepsy. Parenteral formulations of old anticonvulsants are still a cornerstone in acute seizure management and are approved by the FDA. Intravenous levetiracetam, a second generation anticonvulsant, is approved by the FDA as an adjunctive treatment in patients 16 years or older when oral administration is not available. Data have shown that it has a unique mechanism of action, linear pharmacokinetics and no known drug interactions with other anticonvulsants. In this paper, we will review the current literature about the pharmacology and pharmacokinetics of intravenous levetiracetam and the safety profile of this new anticonvulsant in acute seizure management of both adults and children.

  19. Ethnobotany, biochemistry and pharmacology of Minthostachys (Lamiaceae). (United States)

    Schmidt-Lebuhn, A N


    The South American mint genus Minthostachys is of great importance in the Andes as a medicinal, aromatic, culinary and commercial essential oil plant. After decades of taxonomic confusion and virtual indeterminability of specimens, new systematic and taxonomic work has been conducted in recent years. The present paper attempts to summarize the state of knowledge about Minthostachys with a focus on ethnobotany, analyses of essential oil content and pharmacology, to identify the currently accepted species names for the plants examined in these previous studies, and to assess where additional research is needed. All available studies on Minthostachys were obtained and evaluated. Herbaria were contacted to identify voucher specimens cited in the respective publications. The great majority of published studies was conducted on a single species, Argentinean Minthostachys verticillata. In contrast, the most widely distributed and well-known species (Minthostachys mollis) as well as several locally important and intensively used species (e.g., Minthostachys acutifolia) have received disproportionately little attention, and virtually nothing is known about the local endemics among the 17 species currently recognized. In many cases, however, it is difficult to relate the results to taxonomic entities due to the lack of voucher specimens. Future research efforts should especially be directed at studying the chemistry and potential for use of several common but so far neglected species of the central and northern Andes, at disentangling environmental and genetic influences on essential oil composition, at prerequisites for cultivation, and at the pharmacological basis of the most important traditional uses. Because of the morphological complexity of the genus, future researchers are urged to deposit voucher specimens of the plants used in their studies to facilitate species identification and to make the results more comparable and reproducible.

  20. Clinical pharmacology of atovaquone and proguanil hydrochloride. (United States)

    Beerahee, M


    Atovaquone and proguanil hydrochloride is a new antimalarial combination that is used for treatment and prophylaxis of malaria. The clinical pharmacology of atovaquone and proguanil was reviewed. Atovaquone is a highly lipophilic compound with low aqueous solubility, the absorption of which is limited by the rate and extent of dissolution. Dietary fat increases the rate and extent of atovaquone absorption, increasing AUC two- to threefold and C(max) fivefold over fasting. Proguanil is rapidly and extensively absorbed regardless of food intake. Atovaquone is highly protein bound (> 99%) but does not displace other highly protein bound drugs in vitro, indicating significant drug interactions arising from displacement are unlikely. Atovaquone is predominantly eliminated unchanged in feces, with negligible excretion in urine. Proguanil is partially metabolized and partially excreted unchanged in urine. Its principal metabolite, cycloguanil, is also excreted in urine. Metabolism of proguanil is mediated in the liver by the cytochrome P450 3A and 2C subfamilies. The elimination half-life of atovaquone is 2 to 3 days in adults and 1 to 2 days in children. The elimination half-lives of proguanil and cycloguanil are 12 to 15 hours in adults and children. Dosage adjustments based on body weight categories in children (1/4 dose for 11-20 kg, 1/2 dose for > 20-30 kg, 3/4 dose for > 30-40 kg, and full dose for > 40 kg) achieve plasma concentrations that are safe and effective during prophylaxis and treatment of malaria. No dose adjustments for race, proguanil metabolizer status, gender, or elderly patients are needed, or for patients with mild to moderately impaired renal or hepatic function. The clinical pharmacology of atovaquone and proguanil provides a rationale for the dosing regimens recommended for treatment and prophylaxis of malaria.

  1. Pharmacological treatment of the benign prostatic hyperplasia

    International Nuclear Information System (INIS)

    Perez Guerra, Yohani; Molina Cuevas, Vivian; Oyarzabal Yera, Ambar; Mas Ferreiro, Rosa


    Benign prostatic hyperplasia is a common disease in over 50 years-old men consisting in uncontrolled and benign growth of prostatic gland that leads to lower urinary tract symptoms. The etiology of benign prostatic hyperplasia is multifactoral involving the increased conversion of testosterone in dihydrotestosterone by the prostatic 5α-reductase action, which brought about events that encourage the prostate growth (static component) and the increase of the bladder and prostate smooth muscle tone (dynamic component) regulated by the aα 1 -adrenoceptors (ADR). The pharmacological treatment of the benign prostatic hyperplasia includes the prostatic 5aα-reductase inhibitors, the aα 1 -adrenoreceptor blockers, their combined therapy and the phytotherapy. This paper was aimed at presenting the most relevant aspects of the pharmacology of drugs used for treating the benign prostatic hyperplasia, and providing elements to analyze their efficacy, safety and tolerability. To this end, a review was made of the different drugs for the treatment of this pathology and they were grouped according to their mechanism of action. Natural products were included as lipid extracts from Serenoa repens and Pygeum africanum as well as D-004, a lipid extract from Roystonea regia fruits, with proved beneficial effects on the main etiological factors of benign prostatic hyperplasia. D-004 is a prostatic 5a-reductase inhibitor, an aα 1 -adrenoceptor antagonist, aα 5-lipooxygenase inhibitor and has antioxidant action, all of which reveals a multifactoral mechanism. The results achieved till now indicate that D-004 is a safe and well-tolerated product

  2. The Safety Pharmacology Society salary survey. (United States)

    Pugsley, Michael K; Authier, Simon; Brabham, Tiffini; Soloviev, Maxim; Markgraf, Carrie G; Correll, Krystle; Traebert, Martin; Greiter-Wilke, Andrea; Valentin, Jean-Pierre; Vargas, Hugo; Botchway, Alfred; Leishman, Derek J; Curtis, Michael J


    Safety pharmacology is a growing discipline with scientists broadly distributed across international geographical regions. This electronic salary survey is the first to be distributed amongst the entire Safety Pharmacology Society (SPS) membership. An electronic survey was sent to all members of the Society. Categorical survey questions assessed membership employment types, annual incomes, and professional certifications, along with other associated career attributes. This survey was distributed to the SPS membership that is comprised of safety pharmacologists, toxicologists and pharmacologists working globally in the pharmaceutical industry, at contract research organizations (CRO), regulatory agencies, and academia or within the technology provider industry. The survey was open for responses from December 2015 to March 2016. The survey response rate was 28% (129/453). North America (68%) was the region with the largest number of respondents followed by Europe (28%). A preponderance of respondents (77%) had 12years of industry experience or more. 52% of responders earned annually between $40,000 and $120,000. As expected, salary was generally positively correlated with the number of years of experience in the industry or the educational background but there was no correlation between salary and the number of employee's directly supervised. The median salary was higher for male vs female respondents, but so was median age, indicative of no gender 'salary gap'. Our 2016 SPS salary survey results showcased significant diversity regarding factors that can influence salary compensation within this discipline. These data provided insights into the complex global job market trends. They also revealed the level of scientific specialization embedded within the organization, presently uniquely positioned to support the dynamic career paths of current and future safety pharmacologists. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. Pharmacological management of obesity in pediatric patients. (United States)

    Boland, Cassie L; Harris, John Brock; Harris, Kira B


    To review current evidence of pharmacological options for managing pediatric obesity and provide potential areas for future research. A MEDLINE search (1966 to October 2014) was conducted using the following keywords: exenatide, liraglutide, lorcaserin, metformin, obesity, orlistat, pediatric, phentermine, pramlintide, topiramate, weight loss, and zonisamide. Identified articles were evaluated for inclusion, with priority given to randomized controlled trials with orlistat, metformin, glucagon-like peptide-1 agonists, topiramate, and zonisamide in human subjects and articles written in English. References were also reviewed for additional trials. Whereas lifestyle modification is considered first-line therapy for obese pediatric patients, severe obesity may benefit from pharmacotherapy. Orlistat is the only Food and Drug Administration (FDA)-approved medication for pediatric obesity and reduced body mass index (BMI) by 0.5 to 4 kg/m(2), but gastrointestinal (GI) adverse effects may limit use. Metformin has demonstrated BMI reductions of 0.17 to 1.8 kg/m(2), with mild GI adverse effects usually managed with dose titration. Exenatide reduced BMI by 1.1 to 1.7 kg/m(2) and was well-tolerated with mostly transient or mild GI adverse effects. Topiramate and zonisamide reduced weight when used in the treatment of epilepsy. Future studies should examine efficacy and safety of pharmacological agents in addition to lifestyle modifications for pediatric obesity. Lifestyle interventions remain the treatment of choice in pediatric obesity, but concomitant pharmacotherapy may be beneficial in some patients. Orlistat should be considered as second-line therapy for pediatric obesity. Evidence suggests that other diabetes and antiepileptic medications may also provide weight-loss benefits, but safety should be further evaluated. © The Author(s) 2014.

  4. The Objective Structured Clinical Examination (OSCE) as a strategy for assessing clinical competence in midwifery education in Ireland: a critical review. (United States)

    Smith, Valerie; Muldoon, Kathryn; Biesty, Linda


    In Ireland, to register as a midwife, all student midwives must be deemed competent to practice with the assessment of competence an essential component of midwifery education. A variety of assessment strategies, including observed practice, clinical interviews, portfolios of reflection, the Objective Structured Clinical Examination (OSCE) and written examination papers, are utilised to assess midwifery students' clinical competence. In this paper, a critical review of the OSCE as a strategy for assessing clinical competence in one third level institution in Ireland is offered. Although utilised for assessing competence across a range of areas (e.g. obstetric emergencies and pharmacology/drug administration), the use of the OSCE for assessing midwifery students' competence in lactation and infant feeding practices, as an example for this paper, is described. The advantages, disadvantages, validity and reliability of the OSCE, as an assessment strategy, are critically explored. Recognising that no single assessment strategy can provide all the information required to assess something as complex as clinical performance, the OSCE, when viewed alongside other forms of assessment, and with relevance to the topic under examination, may be considered a valuable strategy for enhancing the assessment of students' clinical competence, and for embracing diversity within midwifery education and training. Copyright © 2012 Elsevier Ltd. All rights reserved.

  5. An exploration of the knowledge and attitudes towards breastfeeding among a sample of Chinese mothers in Ireland

    LENUS (Irish Health Repository)

    Zhou, Qianling


    Abstract Background Psychological factors are important in influencing breastfeeding practices. This retrospective study explored knowledge and attitudes related to breastfeeding of Chinese mothers living in Ireland. Methods A cross-sectional self-administrated survey written in Chinese was distributed to a convenience sample of 322 immigrant Chinese mothers mainly via Chinese supermarkets and Chinese language schools in Dublin, with the involvement of the snowball method to increase sample size. Maternal breastfeeding knowledge and attitudes were described, their associations with socio-demographic variables were explored by Chi-square analysis, and their independent associations with breastfeeding behaviours were estimated by binary logistic regression analyses. Results In spite of considerable awareness of the advantages of breastfeeding (mean score = 4.03 ± 0.73), some misconceptions (e.g. \\'mother should stop breastfeeding if she catches a cold\\') and negative attitudes (e.g. breastfeeding inconvenient, embarrassing, and adverse to mothers\\' figure) existed, especially among the less educated mothers. Cultural beliefs concerning the traditional Chinese postpartum diet were prevalent, particularly among those who had lived in Ireland for a shorter duration (P = 0.004). Psychological parameters had strong independent associations with breastfeeding practices in this study. Those who had lower awareness score (OR = 2.98, 95% CI: 1.87-4.73), more misconceptions and negative attitudes (P < 0.05), and weaker cultural beliefs (P < 0.05) were less likely to breastfeed. Conclusions Findings highlight a need to focus resources and education on correcting the misconceptions identified and reversing the negative attitudes towards breastfeeding among Chinese mothers in Ireland, in particular those with primary\\/secondary level of education. Mothers\\' cultural beliefs should also be acknowledged and understood by healthcare providers.

  6. Towards a ‘Journalism of Opposition’: BBC Northern Ireland, Hearts and Minds and the Good Friday Agreement

    Directory of Open Access Journals (Sweden)

    Julia Paul


    Full Text Available The signing of the 1998 Good Friday Agreement (GFA is regarded as the gateway to Northern Ireland’s path to a re-integrated society. However, it also presented a sizable challenge to the region’s journalists. Newspaper journalism was still divided along sectarian lines, while covering the conflict had led to re-active rather than pro-active reporting. The promise of devolution meant there would eventually be constitutional politics to cover at Stormont. BBC Northern Ireland had recognised this in 1996 with the launch of 'Hearts and Minds', the first television programme devoted to politics produced for a local audience. However, by the end of the first decade of the 21st century, the consociational system of government at Stormont meant the Assembly was beginning to stagnate. I argue that BBC 'Hearts and Minds' paved the way for a change in reporting on politics, which led to some sections of the Northern Ireland media developing a ‘journalism of opposition’. This research offers a departure from much of the previous literature examining the coverage of Northern Ireland focussing as it does on the local media after the GFA. In addition, it offers a unique perspective: I was the assistant producer of 'Hearts and Minds' between 2006 and 2012 when the programme ended. My involvement in the production process means I am uniquely placed to explore its significance. This research draws together my experience with a more analytical framing to draw on the work of, in particular, David Butler (1995 and situates the analysis within this context.

  7. Young people's perceptions of tobacco packaging: a comparison of EU Tobacco Products Directive & Ireland's Standardisation of Tobacco Act (United States)

    Babineau, Kate; Clancy, Luke


    Objectives To measure young people's perceptions of tobacco packaging according to two current pieces of legislation: The EU Tobacco Products Directive (TPD) and Ireland's Public Health (Standardisation of Tobacco Products) Act. Design Within-subject experimental cross-sectional survey of a representative sample of secondary school students. School-based pen and paper survey. Setting 27 secondary schools across Ireland, randomly stratified for size, geographic location, gender, religious affiliation and school-level socioeconomic status. Data were collected between March and May 2014. Participants 1378 fifth year secondary school students aged 16–17 in Ireland. Main outcome measures Young people's perceptions of attractiveness, health risk and smoker characteristics of packs according to EU and Irish branding and packaging guidelines. Results Packs with more branding elements were thought to be healthier than standardised packs for Silk Cut (χ2=158.58, p<0.001), Marlboro (χ2=113.65, p<0.001), and Benson and Hedges (χ2=137.95, p<0.001) brands. Generalized estimating equation binary regressions found that gender was a significant predictor of pack attractiveness for Silk Cut, with females being more likely to find the EU packs attractive (β=−0.45, p=0.007). Gender was a significant predictor for females with regards to the perceived popularity of the Silk Cut brand (β=−0.37, p=0.03). Conclusions The removal of brand identifiers, including colour, font and embossing, reduces the perceived appeal of cigarette packs for young people across all three tested brands. Packs standardised according to Irish legislation are perceived as less attractive, less healthy and smoked by less popular people than packs which conform to the EU TPD 2014 guidelines. PMID:26048206

  8. Pharmacological and non-pharmacological treatment options for depression and depressive symptoms in hemodialysis patients

    Directory of Open Access Journals (Sweden)

    Stefania S. Grigoriou


    Full Text Available Depression is a mental disorder with a high prevalence among patients with end stage renal disease (ESRD. It is reported that depression afflicts approximately 20-30% of this patient population, being associated, amongst other, with high mortality rate, low adherence to medication and low perceived quality of life. There is a variety of medications known to be effective for the treatment of depression but due to poor adherence to treatment as well as due to the high need for medications addressing other ESRD comorbidities, depression often remains untreated. According to the literature, depression is under-diagnosed and undertreated in the majority of the patients with chronic kidney disease. In the current review the main pharmacological and non-pharmacological approaches and research outcomes for the management of depressive symptoms in hemodialysis patients are discussed.

  9. Proposed Nuclear Power Plants in the UK-Potential Radiological Implications for Ireland

    Energy Technology Data Exchange (ETDEWEB)

    McMahon, C.; Kelleher, K.; McGinnity, P.; Organo, C.; Smith, K.; Currivan, L.; Ryan, T.


    The UK Government has identified up to eight locations for the construction of new nuclear power plants by 2025. Five of these locations are on the Irish Sea coast. The Radiological Protection Institute of Ireland, RPII was requested by the Minister for the Environment, Community and Local Government to undertake an assessment of the potential radiological impacts on Ireland from this New Build Programme. This report presents the findings of the potential impacts on Ireland of both the anticipated routine radioactive discharges and of a range of postulated nuclear accident scenarios. The following points are the principal findings of the report. Given the prevailing wind direction in Ireland, radioactive contamination in the air, either from routine operation of the proposed nuclear power plants or accidental releases, will most often be transported away from Ireland. The routine operation of the proposed nuclear power plants will have no measurable radiological impact on Ireland or the Irish marine environment. The severe accident scenarios assessed ranged in their estimated frequency of occurrance from 1 in 50,000 to 1 in 33 million per year. The assessment used a weather pattern that maximised the transfer of radioactivity to Ireland. For the severe accident scenarios assessed, food controls or agriculture protective measures would generally be required in Ireland to reduce exposure of the population so as to mitigate potential long-term health effects. In the accident scenario with an estimated 1 in 33 million chance of occurring, short-term measures such as staying indoors would also be advised as a precautionary measure. In general, the accidents with higher potential impact on Ireland are the ones least likely to occur. Regardless of the radiological impact, any accident at the proposed nuclear power plants leading to an increase of radioactivity levels in Ireland would have a socio-economic impact on Ireland. A major accidental release of radioactivity to

  10. Proposed Nuclear Power Plants in the UK-Potential Radiological Implications for Ireland

    International Nuclear Information System (INIS)

    McMahon, C.; Kelleher, K.; McGinnity, P.; Organo, C.; Smith, K.; Currivan, L.; Ryan, T.


    The UK Government has identified up to eight locations for the construction of new nuclear power plants by 2025. Five of these locations are on the Irish Sea coast. The Radiological Protection Institute of Ireland, RPII was requested by the Minister for the Environment, Community and Local Government to undertake an assessment of the potential radiological impacts on Ireland from this New Build Programme. This report presents the findings of the potential impacts on Ireland of both the anticipated routine radioactive discharges and of a range of postulated nuclear accident scenarios. The following points are the principal findings of the report. Given the prevailing wind direction in Ireland, radioactive contamination in the air, either from routine operation of the proposed nuclear power plants or accidental releases, will most often be transported away from Ireland. The routine operation of the proposed nuclear power plants will have no measurable radiological impact on Ireland or the Irish marine environment. The severe accident scenarios assessed ranged in their estimated frequency of occurrance from 1 in 50,000 to 1 in 33 million per year. The assessment used a weather pattern that maximised the transfer of radioactivity to Ireland. For the severe accident scenarios assessed, food controls or agriculture protective measures would generally be required in Ireland to reduce exposure of the population so as to mitigate potential long-term health effects. In the accident scenario with an estimated 1 in 33 million chance of occurring, short-term measures such as staying indoors would also be advised as a precautionary measure. In general, the accidents with higher potential impact on Ireland are the ones least likely to occur. Regardless of the radiological impact, any accident at the proposed nuclear power plants leading to an increase of radioactivity levels in Ireland would have a socio-economic impact on Ireland. A major accidental release of radioactivity to

  11. A network pharmacology approach to investigate the pharmacological effects of Guizhi Fuling Wan on uterine fibroids. (United States)

    Zeng, Liuting; Yang, Kailin; Liu, Huiping; Zhang, Guomin


    To investigate the pharmacological mechanism of Guizhi Fuling Wan (GFW) in the treatment of uterine fibroids, a network pharmacology approach was used. Information on GFW compounds was collected from traditional Chinese medicine (TCM) databases, and input into PharmMapper to identify the compound targets. Genes associated with uterine fibroids genes were then obtained from the GeneCards and Online Mendelian Inheritance in Man databases. The interaction data of the targets and other human proteins was also collected from the STRING and IntAct databases. The target data were input into the Database for Annotation, Visualization and Integrated Discovery for gene ontology (GO) and pathway enrichment analyses. Networks of the above information were constructed and analyzed using Cytoscape. The following networks were compiled: A compound-compound target network of GFW; a herb-compound target-uterine fibroids target network of GWF; and a compound target-uterine fibroids target-other human proteins protein-protein interaction network, which were subjected to GO and pathway enrichment analyses. According to this approach, a number of novel signaling pathways and biological processes underlying the effects of GFW on uterine fibroids were identified, including the negative regulation of smooth muscle cell proliferation, apoptosis, and the Ras, wingless-type, epidermal growth factor and insulin-like growth factor-1 signaling pathways. This network pharmacology approach may aid the systematical study of herbal formulae and make TCM drug discovery more predictable.

  12. Trophic level responses differ as climate warms in Ireland (United States)

    Donnelly, Alison; Yu, Rong; Liu, Lingling


    Effective ecosystem functioning relies on successful species interaction. However, this delicate balance may be disrupted if species do not respond to environmental change at a similar rate. Here we examine trends in the timing of spring phenophases of groups of species occupying three trophic levels as a potential indicator of ecosystem response to climate warming in Ireland. The data sets were of varying length (1976-2009) and from varying locations: (1) timing of leaf unfolding and May Shoot of a range of broadleaf and conifer tree species, (2) first appearance dates of a range of moth species, and (3) first arrival dates of a range of spring migrant birds. All three groups revealed a statistically significant ( Pphenology that was driven by rising spring temperature ( P<0.05; 0.45 °C /decade). However, the rate of advance was greater for moths (1.8 days/year), followed by birds (0.37 days/year) and trees (0.29 days/year). In addition, the length of time between (1) moth emergence and leaf unfolding and (2) moth emergence and bird arrival decreased significantly ( P<0.05 and P<0.001, respectively), indicating a decrease in the timing between food supply and demand. These differing trophic level response rates demonstrate the potential for a mismatch in the timing of interdependent phenophases as temperatures rise. Even though these data were not specifically collected to examine climate warming impacts, we conclude that such data may be used as an early warning indicator and as a means to monitor the potential for future ecosystem disruption to occur as climate warms.

  13. Helicobacter pylori resistance to metronidazole and clarithromycin in Ireland.

    LENUS (Irish Health Repository)

    O'connor, Anthony


    INTRODUCTION: Helicobacter pylori eradication rates have fallen considerably in recent years. Antibiotic resistance is thought to be rising. OBJECTIVES: To examine the levels of resistance to metronidazole (MTZ) and clarithromycin (CLA) in H. pylori, isolates were taken in a reference centre in Ireland from 2007 to 2008 and were compared to a similar cohort from a study in 1997. METHOD: Antimicrobial susceptibilities were tested by E-test. Frequencies of spontaneous metronidazole and clarithromycin resistance were measured on an agar plate containing the antibiotics at concentrations of 2x and 4x minimum inhibition concentration values. Clinical data were obtained from charts, laboratory and endoscopy reports. RESULTS: Two hundred and twenty-two patients were analyzed, 98 were females. Colonies amenable to culture were grown in 219 patients. Thirty-seven had prior attempts at eradication therapy (all with amoxicillin-CLA-proton pump inhibitor. A total of 31.5% of the patients had strains resistant to MTZ and 13.2% of the patients were noted to have strains resistant to CLA. About 8.6% of the patients had strains resistant to both the agents. CLA resistance was 9.3% in those who had no prior eradication therapy compared with 32.4% of those who had. CLA resistance increased from 3.9%, among treatment-naive patients in 1997, to 9.3% in our study. MTZ resistance was 29.1% in the treatment-naive population. In 1997, MTZ resistance in the treatment-naive cohort was 27.1%. MTZ resistance was more likely to occur in females (35.4 vs. 28.5%) than in males. CONCLUSION: This study shows that resistance to CLA among Irish patients infected with H. pylori has increased since 1997. The future of treatment may well lie in the widespread use of sensitivity testing before the treatment. This would promote an accurate treatment.

  14. The prevalence of alpha-1 antitrypsin deficiency in Ireland.

    LENUS (Irish Health Repository)

    Carroll, Tomas P


    Abstract Background Alpha-1 antitrypsin deficiency (AATD) results from mutations in the SERPINA1 gene and classically presents with early-onset emphysema and liver disease. The most common mutation presenting with clinical evidence is the Z mutation, while the S mutation is associated with a milder plasma deficiency. AATD is an under-diagnosed condition and the World Health Organisation recommends targeted detection programmes for AATD in patients with chronic obstructive pulmonary disease (COPD), non-responsive asthma, cryptogenic liver disease and first degree relatives of known AATD patients. Methods We present data from the first 3,000 individuals screened following ATS\\/ERS guidelines as part of the Irish National Targeted Detection Programme (INTDP). We also investigated a DNA collection of 1,100 individuals randomly sampled from the general population. Serum and DNA was collected from both groups and mutations in the SERPINA1 gene detected by phenotyping or genotyping. Results The Irish National Targeted Detection Programme identified 42 ZZ, 44 SZ, 14 SS, 430 MZ, 263 MS, 20 IX and 2 rare mutations. Analysis of 1,100 randomly selected individuals identified 113 MS, 46 MZ, 2 SS and 2 SZ genotypes. Conclusion Our findings demonstrate that AATD in Ireland is more prevalent than previously estimated with Z and S allele frequencies among the highest in the world. Furthermore, our targeted detection programme enriched the population of those carrying the Z but not the S allele, suggesting the Z allele is more important in the pathogenesis of those conditions targeted by the detection programme.

  15. Occupational lung disease survey of respiratory physicians in Northern Ireland. (United States)

    McKeagney, T F P; Addley, K; Asanati, K


    Respiratory physicians are likely to encounter occupational lung disease (OLD) in their daily practice. To assess the profile of cases being encountered by general respiratory physicians in Northern Ireland (NI) and determine satisfaction with training, confidence in diagnosis and management of OLD. An online survey of all consultant respiratory physicians currently practising in NI. Questions assessed the numbers of new cases seen over the preceding year, case type, satisfaction with specialist registrar training in OLD and degree of confidence in the diagnosis and management of these conditions. Of the 40 consultants identified, the response rate was 80% (n = 32) with 94% of respondents (n = 30) indicating they had dealt with patients suspected of having occupation-related respiratory symptoms. The most commonly encountered OLDs were pleural plaques (91% of respondents), occupational asthma (88%), asbestosis (84%), non-asbestosis pulmonary fibrosis (76%), hypersensitivity pneumonitis (67%) and mesothelioma (66%). Just over one third of consultants (36%, n = 10) indicated a lack of confidence in diagnosis and management of OLD with almost half (48%) dissatisfied with OLD training as a registrar and a further 78% (n = 25) indicating they would value additional training in OLD as a consultant. The majority of respiratory consultants in NI encountered OLD in their day to day practice and half were dissatisfied with their specialist registrar training in OLD and express a lack of confidence in the diagnosis and management of these conditions. This highlights the need for additional training at both registrar and consultant level. © The Author 2015. Published by Oxford University Press on behalf of the Society of Occupational Medicine. All rights reserved. For Permissions, please email:

  16. Black Carbon Measurements From Ireland's Transboundary Network (TXB) (United States)

    Spohn, T. K.; Martin, D.; O'Dowd, C. D. D.


    Black Carbon (BC) is carbonaceous aerosol formed by incomplete fossil fuel combustion. Named for its light absorbing properties, it acts to trap heat in the atmosphere, thus behaving like a greenhouse gas, and is considered a strong, short-lived climate forcer by the International Panel on Climate Change (IPCC). Carbonaceous aerosols from biomass burning (BB) such as forest fires and residential wood burning, also known as brown carbon, affect the ultra violet (UV) light absorption in the atmosphere as well. In 2016 a three node black carbon monitoring network was established in Ireland as part of a Transboundary Monitoring Network (TXB). The three sites (Mace Head, Malin Head, and Carnsore Point) are coastal locations on opposing sides of the country, and offer the opportunity to assess typical northern hemispheric background concentrations as well national and European pollution events. The instruments deployed in this network (Magee Scientific AE33) facilitate elimination of the changes in response due to `aerosol loading' effects; and a real-time calculation of the `loading compensation' parameter which offers insights into aerosol optical properties. Additionally, these instruments have an inbuilt algorithm, which estimates the difference in absorption in the ultraviolet wavelengths (mostly by brown carbon) and the near infrared wavelengths (only by black carbon).Presented here are the first results of the BC measurements from the three Irish stations, including instrument validation, seasonal variation as well as local, regional, and transboundary influences based on air mass trajectories as well as concurrent in-situ observations (meteorological parameters, particle number, and aerosol composition). A comparison of the instrumental algorithm to off-line sensitivity calculations will also be made to assess the contribution of biomass burning to BC pollution events.

  17. Long-term outcomes of treatment of hyperthyroidism in Ireland.

    LENUS (Irish Health Repository)

    Leary, A C


    We investigated the long-term outcome of treatment in 159 patients with hyperthyroidism first seen between 1979 and 1992. Median duration of follow-up was 10 1\\/2 years. We also inquired into current practice for the follow-up of hyperthyroidism by other endocrinologists in Ireland. Seven cases of unrecognised hyperthyroidism (4 per cent) and one of unrecognised hypothyroidism were identified. Among patients with Graves\\' disease, of those treated with an antithyroid drug, 28 per cent were in remission, 68 per cent had relapsed and 4 per cent had become hypothyroid. Of those treated by sub-total thyroidectomy, 31 per cent were in remission, 19 per cent had relapsed, 19 per cent were hypothyroid and 31 per cent were sub-clinically hypothyroid. Among patients treated with radioiodine, 19 per cent were euthyroid, 3 per cent were still hyperthyroid and three-quarters had become hypothyroid. In contrast, after radioiodine for toxic nodular goitre, 63 per cent were euthyroid and only 32 per cent had become hypothyroid (Chi Squared v. Graves\\' disease, P = 0.001). Of 73 patients receiving thyroxine replacement, plasma TSH was normal in only 41 per cent, although 82 per cent of patients had been seen by the family doctor within the previous 12 months. Seven of 17 other endocrinologists undertook long-term follow-up of hyperthyroid patients in their specialist clinics but none was using a computerised system to co-ordinate this. The findings confirm that careful follow-up is required for all hyperthyroid patients. The family doctor is well positioned to undertake this, but education and auditing are required.

  18. Chernobyl related research and radiological protection activities in Ireland

    Energy Technology Data Exchange (ETDEWEB)

    Rafferty, B; Cunningham, J D [Radiological Protection Inst. of Ireland (Ireland)


    Following the Chernobyl accident a programme of monitoring and research was initiated in the Radiological Protection Institute of Ireland to address questions concerning the immediate and longer term impact of the fallout. Prior to the Chernobyl accident the scientific literature contained limited information on the behaviour of radionuclides in the environment and their entry into food-chains. In response to this lack of information the monitoring programme assessed the contamination status following the accident, while the research programme was aimed at gaining a fuller understanding of the processes of radionuclide transfer. Investigations were undertaken into the pathways through which Chernobyl radionuclides may be transferred to man i.e. via agricultural crops, meat and milk production. The results showed that the behaviour of the fallout radionuclides is complex and highly variable, being influenced by weather, topography, season, crop type, land management etc. The research continues today and its aim is to identify pathways of radiation dose transfer to man and to determine strategies for minimising risk and cost to man and the environment. Examination of the factors which control radionuclide behaviour has revealed practical strategies for dealing with contaminated lands and foods. A significant factor controlling the behaviour of radionuclides in ecosystems is the physico-chemical characteristics of the soil. These physico-chemical characteristics have proved to be useful parameters which can be manipulated to reduce the transfer of radionuclides in agricultural systems. In semi-natural ecosystems (peatlands and commercial forests) the controls on the behaviour of radionuclides are generally more complicated and intervention is more difficult. These ecosystems present a challenge in terms of the identification of possible practical rehabilitation measures. (Abstract Truncated)

  19. Initial results from the newborn hearing screening programme in Ireland.

    LENUS (Irish Health Repository)

    O'Connor, A


    INTRODUCTION: Hearing screening programmes aim to detect hearing loss in the neonate. The Health Service Executive (HSE) South was the first phase of a national roll-out of a neonatal hearing screening programme in Ireland, going live on 28 April 2011. RESULTS: Over 11,738 babies have been screened for permanent childhood hearing impairment (PCHI) during the first 12 months. The percentage of eligible babies offered hearing screening was 99.2 %. Only 0.2 % (n = 25) of those offered screening declined. 493 (4 %) were referred for immediate diagnostic audiological assessment. The average time between screen and diagnostic audiology appointment was 2 weeks. 15 (1.3\\/1,000) babies have been identified with a PCHI over the 12-month period. 946 (4 %) babies screened were admitted to the neonatal intensive care unit (NICU) for >48 h. The prevalance of PCHI is 7.3\\/1,000 in the NICU population compared to 0.6\\/1000 in the well baby population. 214 (1.8 % of total babies screened) had a clear response in the screening programmes, but were deemed to be at risk of an acquired childhood hearing impairment. These babies will be reassessed with a diagnostic audiology appointment at 8-9 months of age. To date, there is one case of acquired hearing impairment through this targeted follow-up screen. Of the 15 cases of PCHI identified, 8 (53 %) of these had one or more risk factors for hearing loss and 7 (37 %) were admitted to the NICU for >48 h. Four babies were referred for assessment at the National Cochlear Implant Centre.

  20. The road to smoke-free legislation in Ireland. (United States)

    Currie, Laura M; Clancy, Luke


    To describe the process through which Ireland changed its policies towards smoking in work-places and distil lessons for others implementing or extending smoke-free laws. This analysis is informed by a review of secondary sources including a commissioned media analysis, documentary analysis and key informant interviews with policy actors who provide insight into the process of smoke-free policy development. The policy analysis techniques used include the development of a time-line for policy reform, stakeholder analysis, policy mapping techniques, impact analysis through use of secondary data and a review process. The policy analysis triangle, which highlights the importance of examining policy content, context, actors and processes, will be used as an analytical framework. The importance of the political, economic, social and cultural context emerged clearly. The interaction of the context with the policy process both in identification of need for policy and its formulation demonstrated the opportunity for advocates to exert influence at all points of the process. The campaign to support the legislation had the following characteristics: a sustained consistent simple health message, sustained political leadership/commitment, a strong coalition between the Health Alliance, the Office of Tobacco Control and the Department of Health and Children, with cross-party political support and trade union support. The public and the media support clearly defined the benefit of deliberate and consistent planning and organization of a communication strategy. The Irish smoke-free legislation was a success as a policy initiative because of timing, dedication, planning, implementation and the existence of strong leadership and a powerful convinced credible political champion. © 2010 The Authors, Addiction © 2010 Society for the Study of Addiction.