WorldWideScience

Sample records for pet imagining agent

  1. Modular strategies for PET imaging agents

    International Nuclear Information System (INIS)

    Hooker, J.M.

    2010-01-01

    In recent years, modular and simplified chemical and biological strategies have been developed for the synthesis and implementation of positron emission tomography (PET) radiotracers. New developments in bioconjugation and synthetic methodologies, in combination with advances in macromolecular delivery systems and gene-expression imaging, reflect a need to reduce radiosynthesis burden in order to accelerate imaging agent development. These new approaches, which are often mindful of existing infrastructure and available resources, are anticipated to provide a more approachable entry point for researchers interested in using PET to translate in vitro research to in vivo imaging.

  2. Development of (F-18)-Labeled Amyloid Imaging Agents for PET

    International Nuclear Information System (INIS)

    Mathis, C.A.

    2007-01-01

    The applicant proposes to design and synthesize a series of fluorine-18-labeled radiopharmaceuticals to be used as amyloid imaging agents for positron emission tomography (PET). The investigators will conduct comprehensive iterative in vitro and in vivo studies based upon well defined acceptance criteria in order to identify lead agents suitable for human studies. The long term goals are to apply the selected radiotracers as potential diagnostic agents of Alzheimer's disease (AD), as surrogate markers of amyloid in the brain to determine the efficacy of anti-amyloid therapeutic drugs, and as tools to help address basic scientific questions regarding the progression of the neuropathology of AD, such as testing the 'amyloid cascade hypothesis' which holds that amyloid accumulation is the primary cause of AD.

  3. Radiotracers for the in vivo PET imagine of acetylcholinesterase in the brain

    International Nuclear Information System (INIS)

    Kilbourn, M.R.; Snyder, S.E.; Nguyen, T.; Koeppe, R.A.; Frey, K.A.; Kuhl, D.E.

    1997-01-01

    Regional brain pharmacokinetics of the piperidinyl esters have been determined in the primate brain, using Positron Emission Tomographic (PET) imaging. The propionate ester shows a faster and more complete rate of hydrolysis in regions of AChE, such as the striatum and the cortex. Regional hydrolysis rates (combined forward rate constants, k3) for these radiotracers can be calculated using a simplified analysis of tissue-time activity curves, without a need for determining metabolite-corrected plasma levels. In the striatum of the monkey, the propionate ester shows a reaction rate with the enzyme that is almost two-fold faster than the isobutyrate ester. These radiolabeled esters form a new approach to the measurement of in vivo function of AChE in the mammalian brain, including humans, and provide a method to assess changes in such enzyme activity as a result of disease or pharmacological intervention

  4. Radiotracers for the in vivo PET imagine of acetylcholinesterase in the brain

    Energy Technology Data Exchange (ETDEWEB)

    Kilbourn, M.R.; Snyder, S.E.; Nguyen, T.; Koeppe, R.A.; Frey, K.A.; Kuhl, D.E. [University of Michigan Medical School, An Arbor (United States). Division of Nuclear Medicine

    1997-10-01

    Regional brain pharmacokinetics of the piperidinyl esters have been determined in the primate brain, using Positron Emission Tomographic (PET) imaging. The propionate ester shows a faster and more complete rate of hydrolysis in regions of AChE, such as the striatum and the cortex. Regional hydrolysis rates (combined forward rate constants, k3) for these radiotracers can be calculated using a simplified analysis of tissue-time activity curves, without a need for determining metabolite-corrected plasma levels. In the striatum of the monkey, the propionate ester shows a reaction rate with the enzyme that is almost two-fold faster than the isobutyrate ester. These radiolabeled esters form a new approach to the measurement of in vivo function of AChE in the mammalian brain, including humans, and provide a method to assess changes in such enzyme activity as a result of disease or pharmacological intervention 10 refs., 5 figs.

  5. Effect of MR contrast agents on quantitative accuracy of PET in combined whole-body PET/MR imaging

    Energy Technology Data Exchange (ETDEWEB)

    Lois, Cristina [University of Santiago de Compostela, Department of Particle Physics, Santiago de Compostela (Spain); Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela (Spain); Imaging Science Institute, Tuebingen (Germany); Bezrukov, Ilja [Eberhard Karls University, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, Department of Preclinical Imaging and Radiopharmacy, Tuebingen (Germany); Max Plank Institute for Intelligent Systems, Department of Empirical Inference, Tuebingen (Germany); Schmidt, Holger [Eberhard Karls University, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, Department of Preclinical Imaging and Radiopharmacy, Tuebingen (Germany); Eberhard Karls University, Diagnostic and Interventional Radiology, Department of Radiology, Tuebingen (Germany); Schwenzer, Nina; Werner, Matthias K. [Eberhard Karls University, Diagnostic and Interventional Radiology, Department of Radiology, Tuebingen (Germany); Kupferschlaeger, Juergen [Eberhard Karls University, Nuclear Medicine, Department of Radiology, Tuebingen (Germany); Beyer, Thomas [Imaging Science Institute, Tuebingen (Germany); cmi-experts GmbH, Zuerich (Switzerland)

    2012-11-15

    Clinical PET/MR acquisition protocols entail the use of MR contrast agents (MRCA) that could potentially affect PET quantification following MR-based attenuation correction (AC). We assessed the effect of oral and intravenous (IV) MRCA on PET quantification in PET/MR imaging. We employed two MRCA: Lumirem {sup registered} (oral) and Gadovist {sup registered} (IV). First, we determined their reference PET attenuation values using a PET transmission scan (ECAT-EXACT HR+, Siemens) and a CT scan (PET/CT Biograph 16 HI-REZ, Siemens). Second, we evaluated the attenuation of PET signals in the presence of MRCA. Phantoms were filled with clinically relevant concentrations of MRCA in a background of water and {sup 18}F-fluoride, and imaged using a PET/CT scanner (Biograph 16 HI-REZ, Siemens) and a PET/MR scanner (Biograph mMR, Siemens). Third, we investigated the effect of clinically relevant volumes of MRCA on MR-based AC using human pilot data: a patient study employing Gadovist {sup registered} (IV) and a volunteer study employing two different oral MRCA (Lumirem {sup registered} and pineapple juice). MR-based attenuation maps were calculated following Dixon-based fat-water segmentation and an external atlas-based and pattern recognition (AT and PR) algorithm. IV and oral MRCA in clinically relevant concentrations were found to have PET attenuation values similar to those of water. The phantom experiments showed that under clinical conditions IV and oral MRCA did not yield additional attenuation of PET emission signals. Patient scans showed that PET attenuation maps are not biased after the administration of IV MRCA but may be biased, however, after ingestion of iron oxide-based oral MRCA when segmentation-based AC algorithms are used. Alternative AC algorithms, such as AT and PR, or alternative oral contrast agents, such as pineapple juice, can yield unbiased attenuation maps. In clinical PET/MR scenarios MRCA are not expected to lead to markedly increased attenuation

  6. AAZTA: an ideal chelating agent for the development of {sup 44}Sc PET imaging agents

    Energy Technology Data Exchange (ETDEWEB)

    Nagy, Gabor; Szikra, Dezso; Trencsenyi, Gyoergy [Scanomed Ltd., Debrecen (Hungary); University of Debrecen, Medical Imaging Clinic (Hungary); Fekete, Aniko [University of Debrecen, Medical Imaging Clinic (Hungary); Garai, Ildiko [Scanomed Ltd., Debrecen (Hungary); Giani, Arianna M.; Negri, Roberto [Dipartimento di Scienze del Farmaco, Universita del Piemonte Orientale, Novara (Italy); Masciocchi, Norberto [Dipartimento di Scienza e Alta Tecnologia e To.Sca.Lab, Universita degli Studi dell' Insubria, Como (Italy); Maiocchi, Alessandro; Uggeri, Fulvio [Bracco Imaging spa, Bracco Research Centre, Colleretto Giacosa (Italy); Toth, Imre [Department of Inorganic and Analytical Chemistry, University of Debrecen (Hungary); Aime, Silvio [Dipartimento di Biotecnologie Molecolari e Scienze della Salute, Centro di Imaging Molecolare e Preclinico, Universita degli Studi di Torino (Italy); Giovenzana, Giovanni B. [Dipartimento di Scienze del Farmaco, Universita del Piemonte Orientale, Novara (Italy); CAGE Chemicals srl, Novara (Italy); Baranyai, Zsolt [Bracco Imaging spa, Bracco Research Centre, Colleretto Giacosa (Italy); Department of Inorganic and Analytical Chemistry, University of Debrecen (Hungary)

    2017-02-13

    Unprecedented fast and efficient complexation of Sc{sup III} was demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)] amino-6-methylperhydro-1,4-d iazepine) under mild experimental conditions. The robustness of the {sup 44}Sc(AAZTA){sup -} chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator. (copyright 2017 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim)

  7. Bimodal MR-PET agent for quantitative pH imaging

    Science.gov (United States)

    Frullano, Luca; Catana, Ciprian; Benner, Thomas; Sherry, A. Dean; Caravan, Peter

    2010-01-01

    Activatable or “smart” magnetic resonance contrast agents have relaxivities that depend on environmental factors such as pH or enzymatic activity, but the MR signal depends on relaxivity and agent concentration – two unknowns. A bimodal approach, incorporating a positron emitter, solves this problem. Simultaneous positron emission tomography (PET) and MR imaging with the biomodal, pH-responsive MR-PET agent GdDOTA-4AMP-F allows direct determination of both concentration (PET) and T1 (MRI), and hence pH. PMID:20191650

  8. Fluorine-18 nuclide and its PET imaging agent

    International Nuclear Information System (INIS)

    Wang Mingfang

    2003-01-01

    Fluorine-18 has predominant physical features with long half-life and the enough time for preparation of radiopharmaceuticals and PET imaging. Also, the chemical nature of fluorine-18 is similar to that of hydrogen, and the fluorine-18 labelled organic molecules can not change the non-labelled molecular character. Therefore, fluorine-18 is widely applied in the labelled glucose, amino acids, fatty acids, nucleotide, receptor-ligand and neurotransmitter molecular etc., with the propose of detecting the blood flow, metabolism, synthesis of the protein and the neurotransmitter function in brain by PET imaging. It is very important in the basic science and clinical research to understand and master the preparation of the fluorine-18 and its labelled compounds

  9. Preparation of Ga-68-NOTA as a renal PET agent and feasibility tests in mice

    International Nuclear Information System (INIS)

    Lee, Ji Youn; Jeong, Jae Min; Kim, Young Ju; Jeong, Hyuk-Jin; Lee, Yun-Sang; Lee, Dong Soo

    2014-01-01

    Introduction: Positron emission tomography (PET) may provide more accurate quantification of kidney function such as glomerular filtration rate (GFR) than gamma imaging. The purpose of these experiments was to prepare and evaluate Ga-68 complexes as potential PET agents for measurement of GFR. Methods: We labeled EDTA, DTPA, DOTA, and NOTA with Ga-68 obtained from a Ge-68/Ga-68-generator and measured the binding to serum and red blood cells. Biodistribution study was performed in male BALB/c mice after intravenous injection together with Cr-51-EDTA as the standard for glomerular filtration rate (GFR) measurement. Animal-PET study was performed using BALB/c mice. Results: All the tested chelating agents except DTPA showed quantitative labeling yields (> 99%). Among them, Ga-68-NOTA showed consistently low binding to both human and mouse RBC and serum protein. Biodistribution study showed no significant difference between Ga-68-NOTA and Cr-51-EDTA groups by one-way analysis of variance (ANOVA) (p > 0.05). Furthermore, the GFR values obtained by Ga-68-NOTA and Cr-51-EDTA were almost same (0.26 ± 0.04 and 0.25 ± 0.04 mL/min, respectively). Animal-PET study showed almost the same GFR (0.25 mL/min) with the values obtained by biodistribution study. Conclusion: We proved that an easy-to-prepare agent Ga-68-NOTA is ideal for renal PET as well as for GFR measurement

  10. Quantitative Evaluation of Tumor Early Response to a Vascular-Disrupting Agent with Dynamic PET.

    Science.gov (United States)

    Guo, Ning; Zhang, Fan; Zhang, Xiaomeng; Guo, Jinxia; Lang, Lixin; Kiesewetter, Dale O; Niu, Gang; Li, Quanzheng; Chen, Xiaoyuan

    2015-12-01

    The purpose of this study is to evaluate the early response of tumors to a vascular-disrupting agent (VDA) VEGF121/recombinant toxin gelonin (rGel) using dynamic [(18)F]FPPRGD2 positron emission tomography (PET) and kinetic parameter estimation. Two tumor xenograft models: U87MG (highly vascularized) and A549 (moderately vascularized), were selected, and both were randomized into treatment and control groups. Sixty-minute dynamic PET scans with [(18)F]FPPRGD2 that targets to integrin αvβ3 were performed at days 0 (baseline), 1, and 3 since VEGF121/rGel treatment started. Dynamic PET-derived binding potential (BPND) and parametric maps were compared with tumor uptake (%ID/g) and the static PET image at 1 h after the tracer administration. The growth of U87MG tumor was obviously delayed upon VEGF121/rGel treatment. A549 tumor was not responsive to the same treatment. BPND of treated U87MG tumors decreased significantly at day 1 (p dynamic PET with [(18)F]FPPRGD2 shows advantages in distinguishing effective from ineffective treatment during the course of VEGF121/rGel therapy at early stage and is therefore more sensitive in assessing therapy response than static PET.

  11. Final Report Summary: Radiation dosimetry of Cu-64-labeled radiotherapy agents using PET [Positron Emission Tomography

    International Nuclear Information System (INIS)

    Anderson, Carolyn J.; Cutler, P.D.

    2002-01-01

    This project began in 1996, and was completed in July 2001. The overall goals were to compare various methods of dosimetry of PET imaging agents, as well as develop more optimal methods. One of the major accomplishments of this grant was the human PET imaging studies of a positron-emitting radiopharmaceutical for somatostatin-receptor imaging, and subsequent dosimetry calculations resulting from this study. In addition, we collaborated with Darrell Fisher and Edmund Hui to develop a MIRD-hamster program for calculating hamster organ and tumor dosimetry in hamster models. Progress was made towards a point kernel approach to more accurately determining absorbed doses to normal organs, as well as towards co-registration of PET and MRI images. This report focuses on the progress made in the last 15 months of the grant, which in general is a summary of the progress over the 5 years the project was ongoing

  12. Transforming a Targeted Porphyrin Theranostic Agent into a PET Imaging Probe for Cancer

    Directory of Open Access Journals (Sweden)

    Jiyun Shi, Tracy W.B. Liu, Juan Chen, David Green, David Jaffray, Brian C. Wilson, Fan Wang, Gang Zheng

    2011-01-01

    Full Text Available Porphyrin based photosensitizers are useful agents for photodynamic therapy (PDT and fluorescence imaging of cancer. Porphyrins are also excellent metal chelators forming highly stable metallo-complexes making them efficient delivery vehicles for radioisotopes. Here we investigated the possibility of incorporating 64Cu into a porphyrin-peptide-folate (PPF probe developed previously as folate receptor (FR targeted fluorescent/PDT agent, and evaluated the potential of turning the resulting 64Cu-PPF into a positron emission tomography (PET probe for cancer imaging. Noninvasive PET imaging followed by radioassay evaluated the tumor accumulation, pharmacokinetics and biodistribution of 64Cu-PPF. 64Cu-PPF uptake in FR-positive tumors was visible on small-animal PET images with high tumor-to-muscle ratio (8.88 ± 3.60 observed after 24 h. Competitive blocking studies confirmed the FR-mediated tracer uptake by the tumor. The ease of efficient 64Cu-radiolabeling of PPF while retaining its favorable biodistribution, pharmacokinetics and selective tumor uptake, provides a robust strategy to transform tumor-targeted porphyrin-based photosensitizers into PET imaging probes.

  13. "Imagine that ..."

    DEFF Research Database (Denmark)

    Nielsen, Lene; Madsen, Sabine; Hansen, Anne Vorre

    2017-01-01

    The topic of this paper is user ideation within front-end innovation. We present and discuss an approach which we refer to as “Imagine that. . . ”. With “Imagine that. . . ” users tell stories of how they imagine they will use a future IT system. The oral stories are captured online using a remot...

  14. PET studies of potential chemotherapeutic agents: Pt. 10

    International Nuclear Information System (INIS)

    Conway, T.; Diksic, M.; McGill Univ., Montreal, PQ

    1991-01-01

    Carbon-11-labeled HECNU [1-(2-chloroethyl)-1-nitroso-3-(2-hydroxyethyl) urea] a potential chemotherapeutic agent, has been prepared by the nitrosation of the corresponding carbon-11-labeled urea, HECU, [1-(2-chloroethyl)-3-(2-hydroxyethyl) urea]. The isomeric byproduct of nitrosation, 1-(2-chloroethyl)-3-nitroso-3-(2-hydroxyethyl) urea can be efficiently removed by preparative scale HPLC on a Partisil column. ( 11 C)-HECU was prepared by reacting ethanolamine with ( 11 C)-2-chloroethyl-isocyanate which was itself prepared by reacting ( 11 C)-phosgene with 2-chloroethylamine hydrochloride suspended in dioxane at 60-65 o C. This synthesis yielded ( 11 C)-HECNU with an average radiochemical purity of 98% in an average radiochemical yield of 18% relative to the radioactivity measured at the end of the 11 C-phosgene introduction. (author)

  15. Pharmacological experiment of 13N-ammonia as PET imaging agent

    International Nuclear Information System (INIS)

    Wang Mingfang; Tang Ganghua; Gao Xiao; Li Zhi; Wu Hubing; Huang Zuhan; Jiang Hong; Zhong Jinmei; Wang Quanshi

    2002-01-01

    . 13 N-ammonia is an ideal myocardial blood flow perfusion imaging agent. rMBF can be measured accurately and noninvasively by 13 N-ammonia dynamic and static PET imaging

  16. The development and preliminary testing of new boronated agents for BNCT based on PET derived data

    International Nuclear Information System (INIS)

    Nichols, T.; Kabalka, G.; Kahn, M.; Das, B.; Das, S.; Bao, W.; Miller, L.

    2000-01-01

    Positron emission tomography (PET) has been utilized at the University of Tennessee for evaluating a variety of tumors including glioblastoma multiforme (GBM) and metastatic malignant melanoma (MM). Studies have been carried out utilizing fluorine-18 labeled p-boronophenylalanine ( 18 F-BPA) and other unnatural amino acids. A comparison of PET studies obtained using 18 F-BPA and a carbon-11 labeled cyclobutane-based amino acid ( 11 C-ACBC) revealed that 11 C-ACBC localized effectively in GBM tumors. Based on these results, we have prepared a series of boronated, aminocyclobutanecarboxylic acids. Preliminary uptake and cell toxicity studies have been carried out and show that many of the agents are not toxic. In one instance, a biodistribution study carried out using nude mice implanted with a human glioblastoma tumor, the tumor to normal tissue uptake of boron exceeds that observed for BPA. (author)

  17. Niger - IMAGINE

    Data.gov (United States)

    Millennium Challenge Corporation — This impact evaluation uses random assignment at the village level to estimate impacts of the IMAGINE program on enrollment, attendance, learning and other education...

  18. Study on folate receptor PET imaging agent 18F-flurophenethyl folate

    International Nuclear Information System (INIS)

    Guo Congying; Zhu Jianhua; Qian Jun; Yang Yang; Shen Haixing; Zhang Zhengwei

    2009-01-01

    This work is aimed at synthesizing an 18 F-labelled folate derivative that can be used as folate-receptor induced tumor PET imaging agent. Under the optimal reaction and testing specification formulated during the cold-labeling experiments, 18 F labeling of folic acid was achieved in three steps of 18 F pre-labeling,bromination and esterification. The receptor binding property of the newly-synthesized folate radio-derivative was studied through β-lactoglobulin binding test. Tumor-bearing nude mice injected with the new compound were used to study whether the derivative can accumulate within tumor issue. Preliminary studies in vitro and in vivo showed that this new PET agent still possessed receptor binding qualities of folic acid. 18 F-flurophenethyl folate remained good affinity and specificity with β-lactoglobulin. Accumulation of activities in tumor tissues was found in tumor-bearing nude mice. A new folate receptor ligand: 18 F-flurophenethyl folate was synthesized,with high yield and good stability. Since the pre-labeling method was used, the fluorine labeling was not directly imposed upon folic acid.In this way, the structure destruction, which happens in high temperature reaction of folic acid, can be avoided. The synthesized folate derivative remained the binding structural quality of folic acid and could bind with the folate-binding protein: β-lactoglobulin. Through the folate receptors located on tumor tissues, 18 F-flurophenethyl folate accumulated in the tumor tissue, exhibiting its potential as a tumor PET imaging agent. (authors)

  19. Managerial Imagination

    Directory of Open Access Journals (Sweden)

    Michael Savvas

    2016-02-01

    Full Text Available This article analyzes the links between imagination and human resource management. The concept imagination has received little scholarly attention within the field of management, despite its potential to inform a number of lines of inquiry. At the present time, much of the research literature on imagination is confined to the visual arts, literature, and education. Human resource (HR professionals could play a part in aligning employees with organizational goals and bring about organizational change if they developed their thinking in a more imaginative way. Developing managerial imagination can help solve the dilemmas and contradictions they face. A diagram is developed, which maps the development of the personnel function and offers four possibilities within a framework. They are biography, personal framing, history, and social structure. The outcome of this analysis provides a development of the personnel function one of which is a globally imaginative HR management. Within such a framework, the concept of “the imaginative performer” is discussed. The implications of combining imagination with management may provide a theoretical and practical way to understanding HR management.

  20. Preparation of carbon black masterbatch for PET using polymeric dispersing agents

    Energy Technology Data Exchange (ETDEWEB)

    Oh, D.H. [Kyungpook National University, Taegu (Korea, Republic of); Lim, J.C. [Pukyong National University, Pusan (Korea, Republic of); Seo, K.H. [Yeungnam College of Science and Technology, Taegu (Korea, Republic of)

    1999-03-01

    Three kinds of copolyesters, dispersing agents, were synthesized from the polycondensation reaction of dimethylterephthalate (DMT), dimethylisophthalate (DMI), sebacic acid (SA), and 1,4-butanediol (BD). Carbon black masterbatches were prepared by mixing carbon black into the dispersing agents (1 : 1.3 weight ratio) in a Brabender Plasticorder Using single screw extruder, masterbatches were compounded with poly(ethylene terephthalate) in 3 wt% concentration and mechanical properties of the compounds were investigated Gel permeation chromatography data implied that thermal degradation of polymeric dispersing agents was not significant through dispersion. Capillary rheometer test showed that PBTI has the highest viscosity and shear sensitivity among the there dispersing agents. Volume resistivities of masterbatch and transmission electron micrographs showed that dispersity of carbon black was improved with increasing melt viscosity of dispersing agent. The ultimate performance and mechanical characteristics of carbon black filled PET compounds depended directly on dispersion quality of the carbon black in masterbatch. Mechanical properties of compounds were improved with increasing dispersity of carbon black and with increasing content of rigid aromatic group in the copolyester dispersing agent. 30 refs., 9 figs., 5 tabs.

  1. Assessment of recycled PET properties for application on oil wells as sand control agents; Avaliacao de propriedades de PET reciclado para aplicacao em pocos de petroleo como agente de contencao de areia

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, Alexandre Zacarias Ignacio [PETROBRAS, Rio de Janeiro, RJ (Brazil); Delpech, Marcia Cerqueira [Universidade do Estado do Rio de Janeiro (IQ/UERJ), RJ (Brazil). Inst. de Quimica], e-mail: mcd@uerj.br

    2008-07-01

    The Sand Control is fundamental for oil production in unconsolidated sandstone formations. It consists of the installation of a filter made of stainless steel screens and grained materials (sand control agents) which are, normally, high density inorganic substances (sand, ceramic, bauxite). Shallow formations, near to the sea bed, are more sensitive and need different kinds of sand control agents with low density. The objective of this work was the evaluation of recycled poly(ethylene terephthalate), PET, as sand control agent for oil wells. Pack permeability and thermal stability tests results, after up to six months of exposure to sea water and crude oil, have indicated that the recycled PET kept the necessary characteristics for the proposed application. Also, it was observed that the PET grain pack did not presented significant property modifications in the exposure conditions, when compared to the non-exposed samples. (author)

  2. Boron in nuclear medicine: New synthetic approaches to PET, SPECT, and BNCT agents

    International Nuclear Information System (INIS)

    Kabalka, G.W.

    1989-10-01

    The primary objective of the DOE Nuclear Medicine Program at The University of Tennessee is the creation of new methods for introducing short-lived isotopes into agents for use in PET and SPECT. A small, but significant portion of our effort is directed toward the design of boron-containing neutron therapy agents. The uniqueness of the UT program is its focus on the design of new chemistry (molecular architecture) and technology as opposed to the application of known reactions to the synthesis of specific radiopharmaceuticals, the new technology is then utilized in nuclear medicine research at the UT Biomedical Imaging Center and in collaboration with colleagues at other DOE facilities (Brookhaven National Laboratory, Oak Ridge National Laboratory, Los Alamos National Laboratory, and Oak Ridge Associated Universities)

  3. PET

    DEFF Research Database (Denmark)

    Mariager, Rasmus Mølgaard; Schmidt, Regin; Heiberg, Morten Rievers

    PET handler om den hemmelige tjenestes arbejde under den kolde krig 1945-1989. Her fortæller Regin Schmidt, Rasmus Mariager og Morten Heiberg om de mest dramatiske og interessante sager fra PET's arkiv. PET er på flere måder en udemokratisk institution, der er sat til at vogte over demokratiet....... Dens virksomhed er skjult for offentligheden, den overvåger borgernes aktiviteter, og den registrerer følsomme personoplysninger. Historien om PET rejser spørgsmålet om, hvad man skal gøre, når befolkningen i et demokrati er kritisk indstillet over for overvågningen af lovlige politiske aktiviteter......, mens myndighederne mener, at det er nødvendigt for at beskytte demokratiet. PET er på en gang en fortælling om konkrete aktioner og begivenheder i PET's arbejde og et stykke Danmarkshistorie. Det handler om overvågning, spioner, politisk ekstremisme og international terrorisme.  ...

  4. Imagining Sound

    DEFF Research Database (Denmark)

    Grimshaw, Mark; Garner, Tom Alexander

    2014-01-01

    We make the case in this essay that sound that is imagined is both a perception and as much a sound as that perceived through external stimulation. To argue this, we look at the evidence from auditory science, neuroscience, and philosophy, briefly present some new conceptual thinking on sound...... that accounts for this view, and then use this to look at what the future might hold in the context of imagining sound and developing technology....

  5. Synthesis of [18F] labeled tetraphenylphosphonium derivatives as a novel myocardial perfusion agent for PET

    International Nuclear Information System (INIS)

    Kim, Dong Yeon; Bom, Hee Seung; Min, Jung Joon; Yu, Kook Hyun

    2007-01-01

    Lipophilic cations including phosphonium salts penetrate the hydrophobic barriers of the plasma and mitochondrial membranes and accumulate in mitochondria in response to the negative inner transmembrane potentials. The development of radiolabeled phosphonium cations as a noninvasive imaging agent may serve as a new molecular 'voltage sensor' probe to investigate the role of mitochondria in the pathophysiology and diagnosis of cancer. Besides, the tetraphenylphosphonium (TPP) salts has been known to be accumulated in cancer cells as well as in cardiomyocytes especially, [18F]labeled tetraphenylphosphonium derivativesare thought to have a potential to be utilized as a novel myocardial or cancer imaging agent for PET. We have synthesized a reference compound fluoroalkyl triphenylphosphonium (n=5, 6, 7, 8) and a labeled compound, [18F]fluoroalkyl triphenylphosphonium (n=5, 6, 7, 8), which via two step nucleophilic substitution of no-carrier-added F-18 fluoride with the precurso in the presence of Kryptofix-2.2.2 and K2CO3. The reference compound fluoroalkyl triphenylphosphonium (n=5, 6, 7, 8) were synthesized in 79∼82% yield and the labeled compound were synthesized in 20∼25% yield respectively. The tetraphenylphosphonium (TPP) salts exhibited accumulation in cancer as well as heart. Therefore, [18F] radiolabeled tetraphenylphosphonium derivatives are thought to have a potential being utilized as a novel PET molecular probe for imaging cancer and myocardium. Thus, the development of [18F] radiolabeled tetraphenylphosphonium derivatives as a noninvasive imaging agent may serve as a new molecular voltage sensor probe to investigate the role of mitochondria in the diagnosis and treatment of ischemic heart disease and cancer

  6. Synthesis of fluorine-18 labeled rhodamine B: A potential PET myocardial perfusion imaging agent

    International Nuclear Information System (INIS)

    Heinrich, Tobias K.; Gottumukkala, Vijay; Snay, Erin; Dunning, Patricia; Fahey, Frederic H.; Ted Treves, S.; Packard, Alan B.

    2010-01-01

    There is considerable interest in developing an 18 F-labeled PET myocardial perfusion agent. Rhodamine dyes share several properties with 99m Tc-MIBI, the most commonly used single-photon myocardial perfusion agent, suggesting that an 18 F-labeled rhodamine dye might prove useful for this application. In addition to being lipophilic cations, like 99m Tc-MIBI, rhodamine dyes are known to accumulate in the myocardium and are substrates for Pgp, the protein implicated in MDR1 multidrug resistance. As the first step in determining whether 18 F-labeled rhodamines might be useful as myocardial perfusion agents for PET, our objective was to develop synthetic methods for preparing the 18 F-labeled compounds so that they could be evaluated in vivo. Rhodamine B was chosen as the prototype compound for development of the synthesis because the ethyl substituents on the amine moieties of rhodamine B protect them from side reactions, thus eliminating the need to include (and subsequently remove) protecting groups. The 2'-[ 18 F]fluoroethyl ester of rhodamine B was synthesized by heating rhodamine B lactone with [ 18 F]fluoroethyltosylate in acetonitrile at 165 deg. C for 30 min using [ 18 F]fluoroethyl tosylate, which was prepared by the reaction of ethyleneglycol ditosylate with Kryptofix 2.2.2, K 2 CO 3 , and [ 18 F]NaF in acetonitrile for 10 min at 90 deg. C. The product was purified by semi-preparative HPLC to produce the 2'-[ 18 F]fluoroethylester in >97% radiochemical purity with a specific activity of 1.3 GBq/μmol, an isolated decay corrected yield of 35%, and a total synthesis time of 90 min.

  7. Synthesis of fluorine-18 labeled rhodamine B: A potential PET myocardial perfusion imaging agent

    Science.gov (United States)

    Heinrich, Tobias K.; Gottumukkala, Vijay; Snay, Erin; Dunning, Patricia; Fahey, Frederic H; Treves, S. Ted; Packard, Alan B.

    2009-01-01

    There is considerable interest in developing an 18F-labeled PET myocardial perfusion agent. Rhodamine dyes share several properties with 99mTc-MIBI, the most commonly used single-photon myocardial perfusion agent, suggesting that an 18F-labeled rhodamine dye might prove useful for this application. In addition to being lipophilic cations, like 99mTc-MIBI, rhodamine dyes are known to accumulate in the myocardium and are substrates for Pgp, the protein implicated in MDR1 multidrug resistance. As the first step in determining whether 18F-labeled rhodamines might be useful as myocardial perfusion agents for PET, our objective was to develop synthetic methods for preparing the 18F-labeled compounds so that they could be evaluated in vivo. Rhodamine B was chosen as the prototype compound for development of the synthesis because the ethyl substituents on the amine moieties of rhodamine B protect them from side reactions, thus eliminating the need to include (and subsequently remove) protecting groups. The 2′-[18F]fluoroethyl ester of rhodamine B was synthesized by heating rhodamine B lactone with [18F]fluoroethyltosylate in acetonitrile at 165°C for 30 min.using [18F]fluoroethyl tosylate, which was prepared by the reaction of ethyleneglycol ditosylate with Kryptofix 2.2.2, K2CO3, and [18F]NaF in acetonitrile for 10 min. at 90°C. The product was purified by semi-preparative HPLC to produce the 2′-[18F]-fluoroethylester in >97% radiochemical purity with a specific activity of 1.3 GBq/μmol, an isolated decay corrected yield of 35%, and a total synthesis time of 90 min. PMID:19783150

  8. Synthesis of fluorine-18 labeled rhodamine B: A potential PET myocardial perfusion imaging agent

    Energy Technology Data Exchange (ETDEWEB)

    Heinrich, Tobias K.; Gottumukkala, Vijay [Division of Nuclear Medicine, Department of Radiology, Children' s Hospital Boston, 300 Longwood Ave., Boston, MA 02115 (United States); Harvard Medical School, Boston, MA 02115 (United States); Snay, Erin; Dunning, Patricia [Division of Nuclear Medicine, Department of Radiology, Children' s Hospital Boston, 300 Longwood Ave., Boston, MA 02115 (United States); Fahey, Frederic H.; Ted Treves, S. [Division of Nuclear Medicine, Department of Radiology, Children' s Hospital Boston, 300 Longwood Ave., Boston, MA 02115 (United States); Harvard Medical School, Boston, MA 02115 (United States); Packard, Alan B. [Division of Nuclear Medicine, Department of Radiology, Children' s Hospital Boston, 300 Longwood Ave., Boston, MA 02115 (United States); Harvard Medical School, Boston, MA 02115 (United States)], E-mail: alan.packard@childrens.harvard.edu

    2010-01-15

    There is considerable interest in developing an {sup 18}F-labeled PET myocardial perfusion agent. Rhodamine dyes share several properties with {sup 99m}Tc-MIBI, the most commonly used single-photon myocardial perfusion agent, suggesting that an {sup 18}F-labeled rhodamine dye might prove useful for this application. In addition to being lipophilic cations, like {sup 99m}Tc-MIBI, rhodamine dyes are known to accumulate in the myocardium and are substrates for Pgp, the protein implicated in MDR1 multidrug resistance. As the first step in determining whether {sup 18}F-labeled rhodamines might be useful as myocardial perfusion agents for PET, our objective was to develop synthetic methods for preparing the {sup 18}F-labeled compounds so that they could be evaluated in vivo. Rhodamine B was chosen as the prototype compound for development of the synthesis because the ethyl substituents on the amine moieties of rhodamine B protect them from side reactions, thus eliminating the need to include (and subsequently remove) protecting groups. The 2'-[{sup 18}F]fluoroethyl ester of rhodamine B was synthesized by heating rhodamine B lactone with [{sup 18}F]fluoroethyltosylate in acetonitrile at 165 deg. C for 30 min using [{sup 18}F]fluoroethyl tosylate, which was prepared by the reaction of ethyleneglycol ditosylate with Kryptofix 2.2.2, K{sub 2}CO{sub 3}, and [{sup 18}F]NaF in acetonitrile for 10 min at 90 deg. C. The product was purified by semi-preparative HPLC to produce the 2'-[{sup 18}F]fluoroethylester in >97% radiochemical purity with a specific activity of 1.3 GBq/{mu}mol, an isolated decay corrected yield of 35%, and a total synthesis time of 90 min.

  9. An experimental phantom study of the effect of gadolinium-based MR contrast agents on PET attenuation coefficients and PET quantification in PET-MR imaging: application to cardiac studies.

    Science.gov (United States)

    O' Doherty, Jim; Schleyer, Paul

    2017-12-01

    Simultaneous cardiac perfusion studies are an increasing trend in PET-MR imaging. During dynamic PET imaging, the introduction of gadolinium-based MR contrast agents (GBCA) at high concentrations during a dual injection of GBCA and PET radiotracer may cause increased attenuation effects of the PET signal, and thus errors in quantification of PET images. We thus aimed to calculate the change in linear attenuation coefficient (LAC) of a mixture of PET radiotracer and increasing concentrations of GBCA in solution and furthermore, to investigate if this change in LAC produced a measurable effect on the image-based PET activity concentration when attenuation corrected by three different AC strategies. We performed simultaneous PET-MR imaging of a phantom in a static scenario using a fixed activity of 40 MBq [18 F]-NaF, water, and an increasing GBCA concentration from 0 to 66 mM (based on an assumed maximum possible concentration of GBCA in the left ventricle in a clinical study). This simulated a range of clinical concentrations of GBCA. We investigated two methods to calculate the LAC of the solution mixture at 511 keV: (1) a mathematical mixture rule and (2) CT imaging of each concentration step and subsequent conversion to LAC at 511 keV. This comparison showed that the ranges of LAC produced by both methods are equivalent with an increase in LAC of the mixed solution of approximately 2% over the range of 0-66 mM. We then employed three different attenuation correction methods to the PET data: (1) each PET scan at a specific millimolar concentration of GBCA corrected by its corresponding CT scan, (2) each PET scan corrected by a CT scan with no GBCA present (i.e., at 0 mM GBCA), and (3) a manually generated attenuation map, whereby all CT voxels in the phantom at 0 mM were replaced by LAC = 0.1 cm -1 . All attenuation correction methods (1-3) were accurate to the true measured activity concentration within 5%, and there were no trends in image

  10. Stress cracking e ataque químico do PET em diferentes agentes químicos Stress cracking and chemical attack of pet under different chemicals

    Directory of Open Access Journals (Sweden)

    Edvânia T. Teófilo

    2009-01-01

    Full Text Available A análise de resistência ao stress cracking (ESCR do PET foi feita em corpos de prova de tração moldados por injeção, utilizando vários agentes químicos (metanol, etanol, propanol, butanol e soluções de hidróxido de sódio em diferentes concentrações. Foram realizados ensaios dinâmicos e estáticos de tração. Durante os testes os corpos de prova foram mantidos em contato com os agentes e as propriedades mecânicas monitoradas. Os resultados evidenciam que todas as soluções de hidróxidos de sódio testadas são agentes agressivos de ESC por diminuírem as propriedades mecânicas do polímero, ocasionando falha catastrófica. Já os demais fluidos, apesar de não terem efeito significativo nas propriedades do PET, afetam drasticamente sua aparência superficial. Observou-se também a ocorrência de ataque químico nos ensaios com NaOH, resultando em redução nas massas molares.The investigation of stress cracking resistance (ESCR of PET was done in injection-moulded tensile test bars using different fluids as active agents. These were methanol, ethanol, propanol, butanol and solutions based on sodium hydroxide. Both dynamic and static tensile experiments were conducted. During the tensile experiments, the samples were kept in contact with the fluids and the mechanical properties were monitored. The results showed that all sodium hydroxide solutions were aggressive stress cracking agents for PET, reducing mechanical properties and causing catastrophic failure. On the other hand, the other fluids did not cause much influence on the mechanical behaviour but changed drastically the surface appearance. Also observed was a chemical attack when NaOH solutions were used, causing a reduction in molar mass of PET molecules.

  11. Harassment: Imaginings.

    Science.gov (United States)

    Wilt, Judith

    1993-01-01

    Imagines the role of the male college professor in view of the erotic and sexual nature of his subjectivity and the glaring possibilities of sexual misconduct with students. Outlines some experiences related to the sexual harassment policies of one private college. (HB)

  12. Material Imagination

    DEFF Research Database (Denmark)

    Folkmann, Mads Nygaard

    2018-01-01

    what before was non-existing. Taking a starting point in the Kantian notion of schematization, which can be seen as the ability to construct meaning through synthesis in the process of human imagination, I take two steps in the article. First, I propose how the creation of design solutions can be seen...

  13. Imagined Physics

    DEFF Research Database (Denmark)

    Merritt, Timothy Robert; Nørgaard, M.; Laursen, C.

    2015-01-01

    to this book focuses on the human responses to objects that change shape in response to input from users, environment, or other circumstances. In this chapter we discuss the term "imagined physics", meaning how actuated devices are in one sense tied to their physical form, yet through the use of actuators...

  14. Preparation and evaluation of 68Ga-ECC as a PET renal imaging agent

    International Nuclear Information System (INIS)

    Mizaei, Alireza; Jaililan, Amir Reza; Mazidi, Mohammad; Aghanejad, Ayuob; Yousefnia, Hassan; Shabani, Gholamli; Ardaneh, Khosro; Geramifar, Patham; Beiki, Davood

    2015-01-01

    Development of a gallium-68-labeled renal tracer can be a good substitute for Tc-99m, a known SPECT tracer. In this study, effort was made to develop 68 Ga-ethylenecysteamine cysteine ( 68 Ga-ECC). Ga-ECC was prepared using generator-based 68 GaCl3 and ethylenecysteamine cysteine (ECC) at optimized conditions. Stability of the complex was checked in human serum followed by partition coefficient determination of the tracer. The biodistribution of the tracer in rats was studied using tissue counting and PET/CT imaging up to 120 min. Ga-ECC was prepared at optimized conditions in 15 min at 90 °C (radiochemical purity ≈97 ± 0.88 % ITLC, >99 % HPLC, specific activity: 210 ± 5 GBq/mM). 68 Ga-ECC was a water-soluble complex based on partition coefficient data (log P; −1.378) and was stable in the presence of human serum for 2 h at 37 °C. The biodistribution of the tracer demonstrated high kidney excretion of the tracer in 10–20 min. The SUV max ratios of the liver to left kidney were 0.38 and 0.39 for 30 and 90 min, respectively, indicating high kidney uptake. Initial biodistribution results showed significant kidney and urinary excretion of the tracer comparable to that of the homologous 99m Tc compound. The complex could be a possible PET kidney imaging agent with a fast imaging time

  15. Preparation and evaluation of {sup 68}Ga-ECC as a PET renal imaging agent

    Energy Technology Data Exchange (ETDEWEB)

    Mizaei, Alireza; Jaililan, Amir Reza; Mazidi, Mohammad; Aghanejad, Ayuob; Yousefnia, Hassan; Shabani, Gholamli; Ardaneh, Khosro [Radiation Application Research School, Nuclear Science and Technology Research Institute, Tehran (Iran, Islamic Republic of); Geramifar, Patham; Beiki, Davood [Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran (Iran, Islamic Republic of)

    2015-09-15

    Development of a gallium-68-labeled renal tracer can be a good substitute for Tc-99m, a known SPECT tracer. In this study, effort was made to develop {sup 68}Ga-ethylenecysteamine cysteine ({sup 68}Ga-ECC). Ga-ECC was prepared using generator-based {sup 68}GaCl3 and ethylenecysteamine cysteine (ECC) at optimized conditions. Stability of the complex was checked in human serum followed by partition coefficient determination of the tracer. The biodistribution of the tracer in rats was studied using tissue counting and PET/CT imaging up to 120 min. Ga-ECC was prepared at optimized conditions in 15 min at 90 °C (radiochemical purity ≈97 ± 0.88 % ITLC, >99 % HPLC, specific activity: 210 ± 5 GBq/mM). {sup 68}Ga-ECC was a water-soluble complex based on partition coefficient data (log P; −1.378) and was stable in the presence of human serum for 2 h at 37 °C. The biodistribution of the tracer demonstrated high kidney excretion of the tracer in 10–20 min. The SUV{sub max} ratios of the liver to left kidney were 0.38 and 0.39 for 30 and 90 min, respectively, indicating high kidney uptake. Initial biodistribution results showed significant kidney and urinary excretion of the tracer comparable to that of the homologous {sup 99m}Tc compound. The complex could be a possible PET kidney imaging agent with a fast imaging time.

  16. Alpha-V Integrin Targeted PET Imagining of Breast Cancer Angiogenesis and Lose-Dose Metronomic Anti-Angiogenic Chemotherapy Efficacy

    National Research Council Canada - National Science Library

    Chen, Xiaoyuan

    2005-01-01

    ...) To demonstrate the feasibility of PET/18F-RGD to image breast tumor growth, spread, and angiogenesis as well as quantifying av-integrin expression level during breast tumor neovascularization overtime. (3...

  17. Embodied Imagination

    DEFF Research Database (Denmark)

    Hansen, Lone Koefoed; Kozel, Susan

    2007-01-01

    ituated in the domain of research into mobile, wireless, networked and wearable computing, this exploratory paperintroduces the embodied imagination method and explains how it can contribute to the design process by creating an elastic space of performance that incorporates daily life and persona...... imagination into the design process. It is based on a study called Placebo Sleeves which was an experiential design phase of a larger project in wearable computing called whisper[s]. The innovation offered by this research is twofold: an integration of previously distinct methodologies......, and an interdisciplinary theoretical framework relevant to the design of devices for affective, networked communication. The methodologies are shaped both by user experience models and by performance practices. We also articulate a domain of public dreaming, located at the conjunction of the private, public and secret...

  18. Labelled agents for PET studies of the dopaminergic system -some quality assurance methods, experience and issues

    International Nuclear Information System (INIS)

    Pike, V.W.; Kensett, M.J.; Turton, D.R.; Waters, S.L.; Silvester, D.J.

    1990-01-01

    Practical methods are described for the quality assurance of three labelled agents (L-6-[ 18 F]fluoro-DOPA, S-[N-methyl- 11 C]nomifensine and [O-methyl- 11 C]raclopride) now produced regularly for PET studies of the dopaminergic system in man. These include indirect methods for the initial determination of label position (e.g. 13 C-NMR spectroscopy) and also direct methods for the assessment of chiral purity (TLC and HPLC) and the routine determination of radiochemical purity, chemical purity and specific activity (HPLC). Mass spectrometry has been used to identify some impurities. L-6-hydroxy-DOPA (a precursor in vivo of the neurotoxin, L-6-hydroxydopamine) has been detected by HPLC in some preparations of L-6-[ 18 F]fluoro-DOPA. Formulated S-[N-methyl- 11 C]nomifensine has been found to be stable. Some quality assurance issues are discussed in relation to experience in the application of the described methods and the obtained results. (author)

  19. Synthesis of 18F labeled clotrimazole derivatives as a potential PET imaging agent

    International Nuclear Information System (INIS)

    Jung, Soon Jae; Kim, In Jong; Park, Jeong Hoon; Lee, Heung Nae; Kim, Sang Wook; Hur, Min Goo; Choi, Sang Moo; Yang, Seung Dae; Yu, Kook Hyun

    2010-01-01

    Clotrimazole [1- -1H-imidazole, CLT] has been reported to inhibit the proliferation of vascular endothelial and act as an in vitro anti-VEGF drug. It is also shown to inhibit angiogenesis in an animal model. The radioisotope labeled clotrimazole derivative can be utilized to monitor the physiologic processes of cancer. In this study, we synthesized [ 18 F]fluoride labeled clotrimazole derivatives as a new tumor imaging agent for PET. The references were prepared by a refluxing with clotrimazole and an excess of fluoroalkyltosylate in acetonitrile for 36 h and clotrimazole reacted with ditosylalkane to give precursors. [ 18 ]Fluoride labeled reaction was performed with precursor in Kryptofix[2.2.2]/K 2 CO 3 for 10 min at 80 .deg. C. The radiolabeling mixture was passed through a silica Sep-Pak cartridge to remove 18 F - . The [ 18 ]F-clotrimazole derivatives were synthesized with a 20 ∼ 25% yield. In the radiofluoriantion step, we used acetonitrile and DMSO as a solvent and observed a higher at the acetonitrile (25%) reaction compared with the DMSO reaction (5%)

  20. Imagining Technicities

    DEFF Research Database (Denmark)

    Liboriussen, Bjarke; Plesner, Ursula

    2011-01-01

    to the elements of taste and skill. In the final analysis those references were synthesized as five imagined technicities: the architect, the engineer, the client, the Chinese, and the Virtual World native. Because technicities are often assumed and rarely discussed as actants who influence practice, their role......, this article focuses on innovative uses of virtual worlds in architecture. We interviewed architects, industrial designers and other practitioners. Conceptually supported by an understanding of technicity found in Cultural Studies, the interviews were then coded with a focus on interviewees’ references...... in cooperation and development of ICTs seems to pass unnoticed. However, since they are aligned into ICTs, technicities impact innovation....

  1. Biodistribution and micro PET imaging of 18F-FECNT as a dopamine transporter imaging agent

    International Nuclear Information System (INIS)

    Chen Zhengping; Wang Songpei; Li Xiaomin; Liu Chunyi; Tang Jie; Lu Chunxiong; Pan Donghui; Xu Yuping; Yang Ming; Jiang Quanfu; Huang Hongbo; Zhou Xingqing

    2009-01-01

    Objective: 2β-carbomethoxy-3β-(4-corophenyl)-8-(2- 18 F-fluoroethyl) nortropane ( 18 F-FECNT) is a recently developed dopamine transporter (DAT) imaging agent. The aim of this study was to evaluate its brain biodistribution and to assess its usefulness in quantitation of DAT density in normal and hemiparkinsonian rats. Methods: Six groups of mice (5 mice each group) received 18 F-FECNT were sacrificed at indicated time post injection. Different brain regions (cortex, hippocampus, striatum, cerebellum) were removed, weighed, and countered. DAT blocking effect was investigated in mice pretreated with 2β-Carbomethoxy-3β-(4-fluorphenyl)tropane (β-CFT) at before 18 F-FECNT injection. MicroPET scans were performed in beth normal and unilaterally 6-hydroxydopamine-lesioned rats. Results: The brain uptake of 18 F-FECNT was 2.22, 1.20, 1.02, 0.78, 0.71, and 0.67 percent injection dose (%ID) at 5, 15, 30, 60, 120, and 180 min post injection. Radioactivity concentration of the striatum, the target region, was the highest in the brain regions and decreased quickly from 5 to 60 min and reached to background at 120 min of post injection. The striatum/cerebellum ratio was 2.56, 3.47, 2.78, 1.63, 0.97, and 0.88 at 5, 15, 30, 60, 120, and 180 min, respectively, post injection. The selective striatum uptake of 1 '8F-FECNT decreased dramatically to the background when the DAT was blocked with β-CFT. The striatum of normal rats in micro-PET exhibited symmetrical (left/right = 1.00 ± 0.05) and the highest uptake of radioactivity (striatum/cerebellum =2.18 ± 0. 16 at 5- 125 min, n =3). As for the hemiparkinsonian rats, nonsymmetrical [unlesioned striatum/cerebellum vs lesioned striatum/cerebellum = 2.01 ± 0.23 (n = 3) vs 1.04 ± 0. 05] and the high-est uptake of radioactivity were also noted. Conclusions: The results suggest that 18 F-FECNT rapidly pas-ses through blood-brain barrier and locates in stiatal region with high affinity and selectivity to DAT. It is a potential

  2. Radiolabelling and evaluation of novel haloethylsulfoxides as PET imaging agents for tumor hypoxia

    International Nuclear Information System (INIS)

    Laurens, Evelyn; Yeoh, Shinn Dee; Rigopoulos, Angela; Cao, Diana; Cartwright, Glenn A.; O'Keefe, Graeme J.; Tochon-Danguy, Henri J.; White, Jonathan M.; Scott, Andrew M.; Ackermann, Uwe

    2012-01-01

    The significance of imaging hypoxia with the PET ligand [ 18 F]FMISO has been demonstrated in a variety of cancers. However, the slow kinetics of [ 18 F]FMISO require a 2-h delay between tracer administration and patient scanning. Labelled chloroethyl sulfoxides have shown faster kinetics and higher contrast than [ 18 F]FMISO in a rat model of ischemic stroke. However, these nitrogen mustard analogues are unsuitable for routine production and use in humans. Here we report on the synthesis and in vitro and in vivo evaluation of two novel sulfoxides which we synthesised from a single precursor molecule via either 2-[ 18 F]fluoroethyl azide click chemistry or conventional nucleophilic displacement of a chloride leaving group. The yields of the click chemistry approach were 90±5% of [ 18 F] based on 2-[ 18 F]fluoroethyl azide, and the yields for the S N reaction were 15±5% of [ 18 F] based on K[ 18 F]F. Both radiotracers underwent metabolism in an in vitro assay using S9 liver fractions with biological half-lives of 32.39 and 43.32 min, respectively. Imaging studies using an SK-RC-52 tumor model in BALB/c nude mice have revealed that only [ 18 F] is retained in hypoxic tumors, whereas [ 18 F] is cleared from those tumors at a rate similar to that of muscle tissue. [ 18 F] has emerged as a promising new lead structure for further development of sulfoxide-based hypoxia imaging agents. In particular, the mechanism of uptake needs to be elucidated and changes to the chemical structure need to be made in order to reduce metabolism and improve radiotracer kinetics.

  3. Radiolabelling and evaluation of a novel sulfoxide as a PET imaging agent for tumor hypoxia

    International Nuclear Information System (INIS)

    Laurens, Evelyn; Yeoh, Shinn Dee; Rigopoulos, Angela; Cao, Diana; Cartwright, Glenn A.; O'Keefe, Graeme J.; Tochon-Danguy, Henri J.; White, Jonathan M.; Scott, Andrew M.; Ackermann, Uwe

    2014-01-01

    [ 18 F]FMISO is the most widely validated PET radiotracer for imaging hypoxic tissue. However, as a result of the pharmacokinetics of [ 18 F]FMISO a 2 h wait between tracer administration and patient scanning is required for optimal image acquisition. In order to develop hypoxia imaging agents with faster kinetics, we have synthesised and evaluated several F-18 labelled anilino sulfoxides. In this manuscript we report on the synthesis, in vitro and in vivo evaluation of a novel fluoroethyltriazolyl propargyl anilino sulfoxide. The radiolabelling of the novel tracer was achieved via 2-[ 18 F]fluoroethyl azide click chemistry. Radiochemical yields were 23 ± 4% based on 2-[ 18 F]fluoroethyl azide and 7 ± 2% based on K[ 18 F]F. The radiotracer did not undergo metabolism or defluorination in an in vitro assay using S9 liver fractions. Imaging studies using SK-RC-52 tumors in BALB/c nude mice have indicated that the tracer may have a higher pO 2 threshold than [ 18 F]FMISO for uptake in hypoxic tumors. Although clearance from muscle was faster than [ 18 F]FMISO, uptake in hypoxic tumors was slower. The average tumor to muscle ratio at 2 h post injection in large, hypoxic tumors with a volume greater than 686 mm 3 was 1.7, which was similar to the observed ratio of 1.75 for [ 18 F]FMISO. Although the new tracer showed improved pharmacokinetics when compared with the previously synthesised sulfoxides, further modifications to the chemical structure need to be made in order to offer significant in vivo imaging advantages over [ 18 F]FMISO

  4. Utility of FMISO PET in advanced head and neck cancer treated with chemoradiation incorporating a hypoxia-targeting chemotherapy agent

    Energy Technology Data Exchange (ETDEWEB)

    Hicks, Rodney J. [Peter MacCallum Cancer Centre, Centre for Molecular Imaging, Melbourne (Australia); University of Melbourne, Department of Medicine, St Vincent' s Medical School, Melbourne (Australia); Rischin, Danny [University of Melbourne, Department of Medicine, St Vincent' s Medical School, Melbourne (Australia); Peter MacCallum Cancer Centre, Division of Haematology and Medical Oncology, Melbourne (Australia); Fisher, Richard [Peter MacCallum Cancer Centre, Centre for Biostatistics and Clinical Trials, Melbourne (Australia); Binns, David [Peter MacCallum Cancer Centre, Centre for Molecular Imaging, Melbourne (Australia); Scott, Andrew M. [Austin Hospital, Centre for PET, and Ludwig Institute for Cancer Research, Melbourne (Australia); Peters, Lester J. [Peter MacCallum Cancer Centre, Division of Radiation Oncology, Melbourne (Australia)

    2005-12-01

    The purpose of the study was to evaluate [{sup 18}F]fluoromisonidazole (FMISO) PET in advanced head and neck cancer during hypoxia-targeting therapy. Fifteen of 16 patients in a phase I trial of chemoradiation plus tirapazamine (specific cytotoxin for hypoxic cells) in advanced (T3/4 and/or N2/3) head and neck cancer underwent serial [{sup 18}F]fluorodeoxyglucose (FDG) and FMISO PET. We have previously reported excellent early clinical outcome of these patients and now review FMISO PET results in the context of longer follow-up of this patient cohort. Based on blinded qualitative scoring by two readers, FMISO PET was positive in 13/15 patients at baseline: 12/15 of primary sites and 8/13 neck nodes were scored as positive. All sites of corresponding FDG and FMISO abnormality at baseline showed marked qualitative reduction of uptake within 4 weeks of commencing therapy, consistent with effective hypoxia-targeted therapy. With a median follow-up of 6.9 years, there have been only four locoregional failures, while three other patients have died of metachronous lung cancer. The 5-year overall survival was 50% (95% CI 27-73%), the 5-year failure-free survival was 44% (95% CI 22-68%) and the 5-year freedom from locoregional failure was 68% (95% CI 38-88%). The high prevalence of hypoxia demonstrated on FMISO PET imaging is consistent with the advanced disease stage of these patients and would be expected to predict an adverse prognosis. Evidence of the early resolution of FMISO abnormality during treatment, associated with excellent locoregional control in this patient cohort, supports further investigation of hypoxia-targeting agents in advanced head and neck cancer. (orig.)

  5. Utility of FMISO PET in advanced head and neck cancer treated with chemoradiation incorporating a hypoxia-targeting chemotherapy agent

    International Nuclear Information System (INIS)

    Hicks, Rodney J.; Rischin, Danny; Fisher, Richard; Binns, David; Scott, Andrew M.; Peters, Lester J.

    2005-01-01

    The purpose of the study was to evaluate [ 18 F]fluoromisonidazole (FMISO) PET in advanced head and neck cancer during hypoxia-targeting therapy. Fifteen of 16 patients in a phase I trial of chemoradiation plus tirapazamine (specific cytotoxin for hypoxic cells) in advanced (T3/4 and/or N2/3) head and neck cancer underwent serial [ 18 F]fluorodeoxyglucose (FDG) and FMISO PET. We have previously reported excellent early clinical outcome of these patients and now review FMISO PET results in the context of longer follow-up of this patient cohort. Based on blinded qualitative scoring by two readers, FMISO PET was positive in 13/15 patients at baseline: 12/15 of primary sites and 8/13 neck nodes were scored as positive. All sites of corresponding FDG and FMISO abnormality at baseline showed marked qualitative reduction of uptake within 4 weeks of commencing therapy, consistent with effective hypoxia-targeted therapy. With a median follow-up of 6.9 years, there have been only four locoregional failures, while three other patients have died of metachronous lung cancer. The 5-year overall survival was 50% (95% CI 27-73%), the 5-year failure-free survival was 44% (95% CI 22-68%) and the 5-year freedom from locoregional failure was 68% (95% CI 38-88%). The high prevalence of hypoxia demonstrated on FMISO PET imaging is consistent with the advanced disease stage of these patients and would be expected to predict an adverse prognosis. Evidence of the early resolution of FMISO abnormality during treatment, associated with excellent locoregional control in this patient cohort, supports further investigation of hypoxia-targeting agents in advanced head and neck cancer. (orig.)

  6. Synthesis, biological evaluation, and baboon PET imaging of the potential adrenal imaging agent cholesteryl-p-[18f]fluorobenzoate

    International Nuclear Information System (INIS)

    Jonson, Stephanie D.; Welch, Michael J.

    1999-01-01

    Cholesteryl-p-[ 18 F]fluorobenzoate ([ 18 F]CFB) was investigated as a potential adrenal positron emission tomography (PET) imaging agent for the diagnostic imaging of adrenal disorders. We describe the synthesis, biodistribution, adrenal autoradiography, and baboon PET imaging of [ 18 F]CFB. The synthesis of [ 18 F]CFB was facilitated by the use of a specially designed microwave cavity that was instrumental in effecting 70-83% incorporation of fluorine-18 in 60 s via [ 18 F]fluoro-for-nitro exchange. Tissue distribution studies in mature female Sprague-Dawley rats showed good accumulation of [ 18 F]CFB in the steroid-secreting tissues, adrenals and ovaries, at 1 h postinjection. The effectiveness of [ 18 F]CFB to accumulate in diseased adrenals was shown through biodistribution studies in hypolipidemic rats, which showed a greater than threefold increase in adrenal uptake at 1 h and increased adrenal/liver and adrenal/kidney ratios. Analysis of the metabolites at 1 h in the blood, adrenals, spleen, and ovaries of hypolipidemic and control rats showed the intact tracer representing greater than 86%, 93%, 92%, and 82% of the accumulated activity, respectively. [ 18 F]CFB was confirmed to selectively accumulate in the adrenal cortex versus the adrenal medulla by autoradiography. Normal baboon PET imaging with [ 18 F]CFB effectively showed adrenal localization as early as 15 min after injection of the tracer, with enhanced adrenal contrast seen at 60-70 min. These results suggest that [ 18 F]CFB may be useful as an adrenal PET imaging agent for assessing adrenal disorders

  7. PEGylated superparamagnetic iron oxide nanoparticles labeled with 68Ga as a PET/MRI contrast agent. A biodistribution study

    International Nuclear Information System (INIS)

    Afsaneh Lahooti; Gruttner, Cordula; Parham Geramifar; Hassan Yousefnia

    2017-01-01

    The purpose of this study is to evaluate the biodistribution of polyethylene glycol (PEG) coated superparamagnetic iron oxide nanoparticles radiolabeled with 68 Ga in normal mice after intravenous administration of this probe. Three mice were sacrificed at specific time intervals. The biodistribution data revealed high uptake by liver and spleen (60.62 and 12.65 %ID/g at 120 min post injection for liver and spleen, respectively). The clearance of other organs was fast. These results suggest that 68 Ga-PEG-SPIONs has magnificent capabilities for applying in (PET-MRI) as a theranostic agent for detection of liver and spleen malignancies. (author)

  8. Multiphase contrast-enhanced CT with highly concentrated contrast agent can be used for PET attenuation correction in integrated PET/CT imaging

    International Nuclear Information System (INIS)

    Aschoff, Philip; Plathow, Christian; Lichy, Matthias P.; Claussen, Claus D.; Pfannenberg, Christina; Beyer, Thomas; Erb, Gunter; Oeksuez, Mehmet Oe.

    2012-01-01

    State-of-the-art positron emission tomography/computed tomography (PET/CT) systems incorporate multislice CT technology, thus facilitating the acquisition of multiphase, contrast-enhanced CT data as part of integrated PET/CT imaging protocols. We assess the influence of a highly concentrated iodinated contrast medium (CM) on quantification and image quality following CT-based attenuation correction (CT-AC) in PET/CT. Twenty-eight patients with suspected malignant liver lesions were enrolled prospectively. PET/CT was performed 60 min after injection of 400 MBq of 18 F-fluorodeoxyglucose (FDG) and following the biphasic administration of an intravenous CM (400 mg iodine/ml, Iomeron 400). PET images were reconstructed with CT-AC using any of four acquired CT image sets: non-enhanced, pre-contrast (n-PET), arterial phase (art-PET), portal venous phase (pv-PET) and late phase (late-PET). Normal tissue activity and liver lesions were assessed visually and quantitatively on each PET/CT image set. Visual assessment of PET following CT-AC revealed no noticeable difference in image appearance or quality when using any of the four CT data sets for CT-AC. A total of 44 PET-positive liver lesions was identified in 21 of 28 patients. There were no false-negative or false-positive lesions on PET. Mean standardized uptake values (SUV) in 36 evaluable lesions were: 5.5 (n-PET), 5.8 (art-PET), 5.8 (pv-PET) and 5.8 (late-PET), with the highest mean increase in mean SUV of 6%. Mean SUV changes in liver background increased by up to 10% from n-PET to pv-PET. Multiphase CT data acquired with the use of highly concentrated CM can be used for qualitative assessment of liver lesions in torso FDG PET/CT. The influence on quantification of FDG uptake is small and negligible for most clinical applications. (orig.)

  9. Biodistribution and stability studies of [18F]Fluoroethylrhodamine B, a potential PET myocardial perfusion agent

    International Nuclear Information System (INIS)

    Gottumukkala, Vijay; Heinrich, Tobias K.; Baker, Amanda; Dunning, Patricia; Fahey, Frederic H.; Treves, S. Ted; Packard, Alan B.

    2010-01-01

    Introduction: Fluorine-18-labeled rhodamine B was developed as a potential positron emission tomography (PET) tracer for the evaluation of myocardial perfusion, but preliminary studies in mice showed no accumulation in the heart suggesting that it was rapidly hydrolyzed in vivo in mice. A study was therefore undertaken to further evaluate this hypothesis. Methods: [ 18 F]Fluoroethylrhodamine B was equilibrated for 2 h at 37 deg. C in human, rat and mouse serum and in phosphate-buffered saline. Samples were removed periodically and assayed by high-performance liquid chromatography. Based on the results of the stability study, microPET imaging and a biodistribution study were carried out in rats. Results: In vitro stability studies demonstrated that [ 18 F]fluoroethylrhodamine B much more stable in rat and human sera than in mouse serum. After 2 h, the compound was >80% intact in rat serum but 18 F-labeled rhodamines should accumulate in the heart. Conclusions: [ 18 F]Fluoroethylrhodamine B is more stable in rat and human sera than it is in mouse serum. This improved stability is demonstrated by the high uptake of the tracer in the rat heart in comparison to the absence of visible uptake in the mouse heart. These observations suggest that 18 F-labeled rhodamines are promising candidates for more extensive evaluation as PET tracers for the evaluation of myocardial perfusion.

  10. The Theatre of Imagining

    DEFF Research Database (Denmark)

    Kallenbach, Ulla

    performance with the audience as active co-players. The dissertation’s examination of the cultural history of imagination via three selected periods uncovers a very complex, variable and diverse conception of imagination: From the perception of imagination in the Renaissance as a reproductive but potentially...

  11. 64Cu radiolabeled nano-materials as bimodal contrast agent for optical imaging and Positron Emission Tomography (PET)

    International Nuclear Information System (INIS)

    Nonat, A.M.; Roux, A.; Yahia-Ammar, A.; Charbonniere, L.J.; Platas-Iglesias, C.; Camerle, F.

    2015-01-01

    Fluorescent nano-crystals made of semiconductor material, also called Quantum Dots, are ideal agents for long-term or real-time optical imaging. They have been found to outperform traditional organic fluorescent dyes in many ways (size-tunable optical properties, high quantum yields, high extinction coefficients, resistance to photo bleaching). We have developed a microwave method for the synthesis of highly luminescent water soluble CdTe x S 1-x nano-crystals (Φ= 53% at 600 nm). Their surface functionalization has been developed and controlled using a Nile-Red derivative as a fluorescent marker. The same coupling strategy will be used to incorporate 64 Cu-radiotracers for PET imaging at the surface of the Quantum Dots. A large variety of poly-aza-macrocyclic ligands, have been studied in order to optimize the in vivo stability of the 64 Cu-radiolabeled complexes and their efficiency as radiopharmaceuticals

  12. The preparation and application of carbon-11 nuclide and its PET imaging agent

    International Nuclear Information System (INIS)

    Wang Mingfang

    2002-01-01

    Carbon-11 is a valuable positron nuclide, for it can be used to replace carbon atom at specific position inside the organic molecules and not change the molecular biochemistry character. Carbon-11 has wide application in the labeling of amino acids, fatty acids, receptor-ligand and neurotransmitter molecular etc, which are used for detecting the blood flow, metabolism, the synthesis of protein and the neurotransmitter function in brain by PET imaging. It is very important in basic science and clinical research to understand and master the preparation of carbon-11 and its labeled compounds

  13. A Potential Dubin-Johnson Syndrome Imaging Agent: Synthesis, Biodistribution, and MicroPET Imaging

    Directory of Open Access Journals (Sweden)

    Jeongsoo Yoo

    2005-01-01

    Full Text Available Dubin-Johnson syndrome (DJS is caused by a deficiency of the human canalicular multispecific organic anion transporter (cMOAT. A new lipophilic copper-64 complex of 1,4,7-tris(carboxymethyl-10-(tetradecyl-1,4,7,10-tetraazadodecane (5 was prepared and evaluated for potential as a diagnostic tool for DJS. The prepared ligand was labeled with 64Cu citrate in high radiochemical purity. In vivo uptake and clearance of the complex was determined through biodistribution studies using normal Sprague-Dawley rats and mutant cMOAT-deficient (TR− rats. In normal rats, the radioactive copper complex was cleared quickly from the body exclusively through the hepatic pathway. The 64Cu complex was taken up rapidly by the liver and quickly excreted into the small intestine and then the upper large intestine, whereas < 1% ID/organ was found in the kidney at all time points post injection. Whereas activity was accumulated continuously in the liver of TR− rats, it was not excreted into the small intestine. MicroPET studies of normal and TR rats were consistent with biodistribution data and showed dramatically different images. This study strongly suggests that cMOAT is involved in excretion of 64Cu-5. The significant difference between the biodistribution data and microPET images of the normal and TR− rats demonstrates that this new 64Cu complex may allow noninvasive diagnosis of DJS in humans.

  14. Water-equivalent oral contrast agents in dual-modality PET/computed tomography scanning: does a little barium make the difference?

    Science.gov (United States)

    Kinner, Sonja; Veit-Haibach, Patrick; Lauenstein, Thomas C; Bockisch, Andreas; Antoch, Gerald

    2009-03-01

    To retrospectively evaluate the performance of two water-equivalent oral contrast agents [locust bean gum (LBG)-mannitol and VoLumen] concerning their potential to distend the bowel while avoiding contrast-associated artifacts in PET/computed tomography. PET/computed tomography examinations of 30 patients with two different oral contrast agents were reviewed. Bowel distension, intraluminal density, and potential contrast-associated artifacts were assessed for stomach, jejunum, and ileum. Statistical significance was tested by Student's t-test. Distension was slightly better in the stomach with VoLumen as compared with LBG-mannitol whereas LBG-mannitol was found to slightly better distend the small bowel. This difference proved to be statistically significant for the jejunum. A statistically significant difference was detected for intraluminal density with higher densities for VoLumen. This difference, however, did not result in a higher incidence of PET artifacts with VoLumen. LBG-mannitol provides excellent bowel distension, thereby avoiding contrast-associated PET artifacts. If this solution is not available, VoLumen provides a satisfactory alternative for bowel distension without relevant PET artifacts.

  15. Synthesis and biological evaluation of [18F]tetrafluoroborate: a PET imaging agent for thyroid disease and reporter gene imaging of the sodium/iodide symporter

    International Nuclear Information System (INIS)

    Jauregui-Osoro, Maite; Sunassee, Kavitha; Weeks, Amanda J.; Berry, David J.; Paul, Rowena L.; Cleij, Marcel; O'Doherty, Michael J.; Marsden, Paul K.; Szanda, Istvan; Blower, Philip J.; Banga, Jasvinder Paul; Clarke, Susan E.M.; Ballinger, James R.; Cheng, Sheue-Yann

    2010-01-01

    The human sodium/iodide symporter (hNIS) is a well-established target in thyroid disease and reporter gene imaging using gamma emitters 123 I-iodide, 131 I-iodide and 99m Tc-pertechnetate. However, no PET imaging agent is routinely available. The aim of this study was to prepare and evaluate 18 F-labelled tetrafluoroborate ([ 18 F]TFB) for PET imaging of hNIS. [ 18 F]TFB was prepared by isotopic exchange of BF 4 - with [ 18 F]fluoride in hot hydrochloric acid and purified using an alumina column. Its identity, purity and stability in serum were determined by HPLC, thin-layer chromatography (TLC) and mass spectrometry. Its interaction with NIS was assessed in vitro using FRTL-5 rat thyroid cells, with and without stimulation by thyroid-stimulating hormone (TSH), in the presence and absence of perchlorate. Biodistribution and PET imaging studies were performed using BALB/c mice, with and without perchlorate inhibition. [ 18 F]TFB was readily prepared with specific activity of 10 GBq/mg. It showed rapid accumulation in FRTL-5 cells that was stimulated by TSH and inhibited by perchlorate, and rapid specific accumulation in vivo in thyroid (SUV = 72 after 1 h) and stomach that was inhibited 95% by perchlorate. [ 18 F]TFB is an easily prepared PET imaging agent for rodent NIS and should be evaluated for hNIS PET imaging in humans. (orig.)

  16. Synthesis, uptake mechanism characterization and biological evaluation of {sup 18}F labeled fluoroalkyl phenylalanine analogs as potential PET imaging agents

    Energy Technology Data Exchange (ETDEWEB)

    Wang Limin [Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104 (United States); Qu Wenchao; Lieberman, Brian P.; Ploessl, Karl [Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104 (United States); Kung, Hank F., E-mail: kunghf@gmail.co [Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104 (United States); Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104 (United States)

    2011-01-15

    Introduction: Amino acids based tracers represent a promising class of tumor metabolic imaging agents with successful clinical applications. Two new phenylalanine derivatives, p-(2-[{sup 18}F]fluoroethyl)-L-phenylalanine (FEP, [{sup 18}F]2) and p-(3-[{sup 18}F]fluoropropyl)-L-phenylalanine (FPP, [{sup 18}F]3) were synthesized and evaluated in comparison to clinically utilized O-(2-[{sup 18}F]fluoroethyl)-L-tyrosine (FET, [{sup 18}F]1). Methods: FEP ([{sup 18}F]2) and FPP ([{sup 18}F]3) were successfully synthesized by a rapid and efficient two-step nucleophilic fluorination of tosylate precursors and deprotection reaction. In vitro cell uptake studies were carried out in 9L glioma cells. In vivo studies, 9L tumor xenografts were implanted in Fisher 344 rats. Results: FEP ([{sup 18}F]2) and FPP ([{sup 18}F]3) could be efficiently labeled within 90 min with good enantiomeric purity (>95%), good yield (11-37%) and high specific activity (21-69 GBq/{mu}mol). Cell uptake studies showed FEP had higher uptake than FPP as well as reference ligand FET ([{sup 18}F]1). Uptake mechanism studies suggested that FEP is a selective substrate for system L and prefers its subtype LAT1. In vivo biodistribution studies demonstrated FEP had specific accumulation in tumor cells and tumor to background ratio reached 1.45 at 60 min. Small animal positron emission tomography (PET) imaging studies showed FEP was comparable to FET for imaging rats bearing 9L tumor model. FEP had high uptake in 9L tumor compared to surrounding tissue and was quickly excreted through urinary tract. Conclusion: Biological evaluations indicate that FEP ([{sup 18}F]2) is a potential useful tracer for tumor imaging with PET.

  17. Potential use of 68Ga-apo-transferrin as a PET imaging agent for detecting Staphylococcus aureus infection

    International Nuclear Information System (INIS)

    Kumar, Vijay; Boddeti, Dilip K.; Evans, Scott G.; Roesch, Frank; Howman-Giles, Robert

    2011-01-01

    Introduction: 67 Ga citrate has been extensively used to detect infection and inflammation since 1971. However, its clinical utility is compromised due to several limitations. The present project explored whether 68 Ga-apo-transferrin ( 68 Ga-TF), when prepared in vitro, is a useful agent for positron emission tomography (PET) imaging of bacterial infection. Methods: An infection was induced in male Wistar rats by injecting 5x10 5 CFU units of Staphyococcus aureus in the right thigh muscle. 68 Ga-TF was synthesized by mixing 68 GaCl 3 with apo-transferrin (TF, 2 mg) in sodium carbonate (0.1 M, pH 7.0) and incubating at 40 o C for 1 h. Animals were injected with 10-15 MBq of 68 Ga-TF containing approximately 0.2 mg TF and imaged at different time intervals using Siemens Biograph PET-CT. Results: When 68 Ga-TF were injected in the infected rats, the infection lesion was detectable within 20 min post injection. The biodistribution showed the uptake at the lesion increased with time as shown by significantly increased standard uptake values for up to 4 h post injection. There was a considerable decrease in the background activity during the same period of study, giving higher target-to-muscle ratios. Blood pool activity at 3 h post injection was insignificant. 68 GaCl 3 (when not conjugated to TF) did not localize at the infection lesion up to 120 min post injection. Conclusion: The preliminary results suggest that 68 Ga-TF is capable of detecting S. aureus infection in the rat model, within an hour after intravenous injection.

  18. We Care about You: Incorporating Pet Characteristics with Educational Agents through Reciprocal Caring Approach

    Science.gov (United States)

    Chen, Zhi-Hong

    2012-01-01

    Although different educational agents have been proposed to facilitate student learning, most of them operate from a "smart" (i.e., intelligent and autonomous) perspective. Recently, a so-called "non-smart" perspective is also attracting increasing interest, and is now regarded as a topic worthwhile of researching. To this end,…

  19. Synthesis and preliminary evaluation of [11C]-(-)-phenylephrine as a functional heart neuronal PET agent

    International Nuclear Information System (INIS)

    Rosario, Renato B. del; Jung, Y.-W.; Caraher, John; Chakraborty, Pulak K.; Wieland, Donald M.

    1996-01-01

    The in vivo behavior of (-)-[ 11 C]phenylephrine (PHEN) is compared with the structurally similar but monoamine oxidase (MAO)-resistant analog (-)-[ 11 C]-m-hydroxyephedrine (HED), which is an established heart neuronal marker. The chiral synthesis of PHEN has been achieved by direct methylation of (-)-m-octopamine with either 11 CH 3 I or CF 3 SO 11 3 CH 3 . These synthetic methods produced PHEN with a specific activity ranging from 500-1000 Ci/mmol, in a radiochemical yield of >50% (EOS) and with an enantiomeric purity of 94-96%. Biodistribution studies indicate the initial uptake of PHEN in rat heart is approximately half that of HED. Following PHEN injection, radioactivity egresses from the rat heart rapidly, with 50% washout occurring from 5 to 60 min. HED washout over this interval was less than 20%. The heart neuronal selectivity determined by desipramine blockade of the amine neuronal transporter was 75-77% compared to 92-95% for HED. Ring-labeled (-)-[ 3 H]phenylephrine gave tissue-to-blood concentration ratios and heart clearance times very similar to PHEN. Rats pretreated with the MAO A inhibitor clorgyline showed higher levels of activity in the heart at 15 and 60 min. Tandem PET studies with PHEN and HED in the closed-chest dog provided excellent heart images with both tracers

  20. Digital landscapes of imagination

    OpenAIRE

    Starlight Vattano

    2014-01-01

    Urban landscapes that exist in the expression of an imaginative sequence define their shape through the digital representation. These hyperreal dimensions, combine imagination and representation as constituents a new reality, which follows the utopian, suprematist and constructivist theories, where the two-dimensional dynamics is transformed into an infinite space in which the imagination creates new forms. Although interpretations of the urban landscape film, put in place a correspondence be...

  1. Boron in nuclear medicine: New synthetic approaches to PET, SPECT, and BNCT agents

    International Nuclear Information System (INIS)

    Kabalka, G.W.

    1991-09-01

    The primary objective of the DOE Nuclear Medicine Program at The University of Tennessee is the creation of new methods for introducing short-lived isotopes into agents for use in computerized tomography. A portion of the research effort is directed toward the development of new synthetic methods for the preparation of boron-containing neutron therapy agents. The uniqueness of the UT program is its focus on the design of new chemistry and technology as opposed to the application of known reactions to the synthesis of specific radiopharmaceuticals. The versatile organic boron reagents are utilized in most of the new chemistry. This new technology is then used in nuclear medicine research at the UT Biomedical Imaging Center and in collaborative research programs with colleagues at other DOE facilities. An important goal of the DOE Nuclear Medicine Program at UT is to provide training for students (predoctoral and postdoctoral) in the scientific aspects of nuclear medicine. 83 refs., 12 figs

  2. Evaluation of 18F-labeled icotinib derivatives as potential PET agents for tumor imaging

    International Nuclear Information System (INIS)

    Hongyu Ren; Hongyu Ning; Jin Chang; Mingxia Zhao; Yong He; Yan Chong; Chuanmin Qi

    2016-01-01

    In this study, three 18 F-labeled crown ether fused anilinoquinazoline derivatives ([ 18 F]11a-c) were synthesized and evaluated as potential tumor imaging probes. The biodistribution results of [ 18 F]11b were good. Compared with [ 18 F]-fludeoxyglucose and l-[ 18 F]-fluoroethyltyrosine in the same animal model, [ 18 F]11b had better tumor/brain, tumor/muscle, and tumor/blood uptake ratios. Overall, these results suggest that [ 18 F]11b is promising as a tumor imaging agent for positron emission tomography. (author)

  3. Novel synthesis and initial preclinical evaluation of (18)F-[FDG] labeled rhodamine: a potential PET myocardial perfusion imaging agent.

    Science.gov (United States)

    AlJammaz, Ibrahim; Al-Otaibi, Basim; AlHindas, Hussein; Okarvi, Subhani M

    2015-10-01

    Myocardial perfusion imaging is one of the most commonly performed investigations in nuclear medicine studies. Due to the clinical importance of [(18)F]-fluoro-2-deoxy-D-glucose ([(18)F]-FDG) and its availability in almost every PET center, a new radiofluorinated [(18)F]-FDG-rhodamine conjugate was synthesized using [(18)F]-FDG as a prosthetic group. In a convenient and simple one-step radiosynthesis, [(18)F]-FDG-rhodamine conjugate was prepared in quantitative radiochemical yields, with total synthesis time of nearly 20 min and radiochemical purity of greater than 98%, without the need for HPLC purification, which make these approaches amenable for automation. Biodistribution studies in normal rats at 60 min post-injection demonstrated a high uptake in the heart (>11% ID/g) and favorable pharmacokinetics. Additionally, [(18)F]-FDG-rhodamine showed an extraction value of 27.63%±5.12% in rat hearts. These results demonstrate that [(18)F]-FDG-rhodamine conjugate may be useful as an imaging agent for the positron emission tomography evaluation of myocardial perfusion. Copyright © 2015 Elsevier Inc. All rights reserved.

  4. Complexes and imagination.

    Science.gov (United States)

    Kast, Verena

    2014-11-01

    Fantasies as imaginative activities are seen by Jung as expressions of psychic energy. In the various descriptions of active imagination the observation of the inner image and the dialogue with inner figures, if possible, are important. The model of symbol formation, as Jung describes it, can be experienced in doing active imagination. There is a correspondence between Jung's understanding of complexes and our imaginations: complexes develop a fantasy life. Complex episodes are narratives of difficult dysfunctional relationship episodes that have occurred repeatedly and are internalized with episodic memory. This means that the whole complex episode (the image for the child and the image for the aggressor, connected with emotions) is internalized and can get constellated in everyday relationship. Therefore inner dialogues do not necessarily qualify as active imaginations, often they are the expression of complex-episodes, very similar to fruitless soliloquies. If imaginations of this kind are repeated, new symbols and new possibilities of behaviour are not found. On the contrary, old patterns of behaviour and fantasies are perpetuated and become cemented. Imaginations of this kind need an intervention by the analyst. In clinical examples different kinds of imaginations are discussed. © 2014, The Society of Analytical Psychology.

  5. Synthesis and biological evaluation of [{sup 18}F]tetrafluoroborate: a PET imaging agent for thyroid disease and reporter gene imaging of the sodium/iodide symporter

    Energy Technology Data Exchange (ETDEWEB)

    Jauregui-Osoro, Maite; Sunassee, Kavitha; Weeks, Amanda J.; Berry, David J.; Paul, Rowena L.; Cleij, Marcel; O' Doherty, Michael J.; Marsden, Paul K.; Szanda, Istvan; Blower, Philip J. [King' s College London, Division of Imaging Sciences, London (United Kingdom); Banga, Jasvinder Paul [King' s College London, Division of Cell and Gene Based Therapy, London (United Kingdom); Clarke, Susan E.M.; Ballinger, James R. [Guy' s and St Thomas' NHS Trust, Department of Nuclear Medicine, London (United Kingdom); Cheng, Sheue-Yann [National Cancer Institute, Laboratory of Molecular Biology, Bethesda (United States)

    2010-11-15

    The human sodium/iodide symporter (hNIS) is a well-established target in thyroid disease and reporter gene imaging using gamma emitters {sup 123}I-iodide, {sup 131}I-iodide and {sup 99m}Tc-pertechnetate. However, no PET imaging agent is routinely available. The aim of this study was to prepare and evaluate {sup 18}F-labelled tetrafluoroborate ([{sup 18}F]TFB) for PET imaging of hNIS. [{sup 18}F]TFB was prepared by isotopic exchange of BF{sub 4} {sup -} with [{sup 18}F]fluoride in hot hydrochloric acid and purified using an alumina column. Its identity, purity and stability in serum were determined by HPLC, thin-layer chromatography (TLC) and mass spectrometry. Its interaction with NIS was assessed in vitro using FRTL-5 rat thyroid cells, with and without stimulation by thyroid-stimulating hormone (TSH), in the presence and absence of perchlorate. Biodistribution and PET imaging studies were performed using BALB/c mice, with and without perchlorate inhibition. [{sup 18}F]TFB was readily prepared with specific activity of 10 GBq/mg. It showed rapid accumulation in FRTL-5 cells that was stimulated by TSH and inhibited by perchlorate, and rapid specific accumulation in vivo in thyroid (SUV = 72 after 1 h) and stomach that was inhibited 95% by perchlorate. [{sup 18}F]TFB is an easily prepared PET imaging agent for rodent NIS and should be evaluated for hNIS PET imaging in humans. (orig.)

  6. Digital landscapes of imagination

    Directory of Open Access Journals (Sweden)

    Starlight Vattano

    2014-05-01

    Full Text Available Urban landscapes that exist in the expression of an imaginative sequence define their shape through the digital representation. These hyperreal dimensions, combine imagination and representation as constituents a new reality, which follows the utopian, suprematist and constructivist theories, where the two-dimensional dynamics is transformed into an infinite space in which the imagination creates new forms. Although interpretations of the urban landscape film, put in place a correspondence between reality and virtuality, into the modeling of spatial movements, from which do not arise contraries, but only interdependencies. It is a particular type of representation that takes shape via the digital in motion and provides new tools for urban representation.

  7. Gettysburg re-imagined

    DEFF Research Database (Denmark)

    Chronis, Athinodoros; Arnould, Eric J.; Hampton, Ronald D.

    2012-01-01

    and expands narrative-based theories of consumption experiences. We argue that the workings of imagination in tourism sites are inextricably linked to the production of cultural imaginaries, that is, socially important narratives invested with collective values; we illustrate the process through which...... narrative of the American Civil War and we explore ethnographically the ways in which this historical episode is (re)imagined and articulated in tourism at Gettysburg. Our research provides an alternative account to mental imagery theory that is based on restrictive cognitive conceptions of imagination...

  8. Multi-modality PET-CT imaging of breast cancer in an animal model using nanoparticle x-ray contrast agent and 18F-FDG

    Science.gov (United States)

    Badea, C. T.; Ghaghada, K.; Espinosa, G.; Strong, L.; Annapragada, A.

    2011-03-01

    Multi-modality PET-CT imaging is playing an important role in the field of oncology. While PET imaging facilitates functional interrogation of tumor status, the use of CT imaging is primarily limited to anatomical reference. In an attempt to extract comprehensive information about tumor cells and its microenvironment, we used a nanoparticle xray contrast agent to image tumor vasculature and vessel 'leakiness' and 18F-FDG to investigate the metabolic status of tumor cells. In vivo PET/CT studies were performed in mice implanted with 4T1 mammary breast cancer cells.Early-phase micro-CT imaging enabled visualization 3D vascular architecture of the tumors whereas delayedphase micro-CT demonstrated highly permeable vessels as evident by nanoparticle accumulation within the tumor. Both imaging modalities demonstrated the presence of a necrotic core as indicated by a hypo-enhanced region in the center of the tumor. At early time-points, the CT-derived fractional blood volume did not correlate with 18F-FDG uptake. At delayed time-points, the tumor enhancement in 18F-FDG micro-PET images correlated with the delayed signal enhanced due to nanoparticle extravasation seen in CT images. The proposed hybrid imaging approach could be used to better understand tumor angiogenesis and to be the basis for monitoring and evaluating anti-angiogenic and nano-chemotherapies.

  9. The advantages and challenges of using FDG PET/CT for response assessment in melanoma in the era of targeted agents and immunotherapy

    International Nuclear Information System (INIS)

    Wong, Annie N.M.; McArthur, Grant A.; Hofman, Michael S.; Hicks, Rodney J.

    2017-01-01

    The treatment of melanoma has been revolutionised in recent years by advances in the understanding of the genomic landscape of this disease, which has led to the development of new targeted therapeutic agents, and the ability to therapeutically manipulate the immune system through inhibition of cancer cell-T-cell interactions that prevent an adaptive immune response. While these therapeutic interventions have dramatically improved the prospects of survival for patients with advanced melanoma, they bring significant complexity to the interpretation of therapeutic response because their mechanisms and temporal profile of response vary considerably. In this review, we discuss the mode of action of these emerging therapies and their toxicities to provide a framework for the use of FDG PET/CT in therapeutic response assessment. We propose that the greatest utility of PET in assessment of response to agents that abrogate signalling related to BRAF mutation is for early assessment of resistance, while in anti-CTLA4 therapy, immunological flare can compromise early assessment of response but can identify potentially life-threatening autoimmune reactions. For anti-PD1/PDL1 therapy, the role of FDG PET/CT is more akin to its use in other solid malignancies undergoing treatment with conventional chemotherapy. However, further research is required to optimise the timing of scans and response criteria in this disease. (orig.)

  10. The advantages and challenges of using FDG PET/CT for response assessment in melanoma in the era of targeted agents and immunotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Wong, Annie N.M.; McArthur, Grant A. [The Peter MacCallum Cancer Centre, Cancer Medicine, Melbourne (Australia); The University of Melbourne, The Sir Peter MacCallum Department of Oncology, Melbourne (Australia); Hofman, Michael S. [The Peter MacCallum Cancer Centre, Cancer Imaging, Melbourne, VIC (Australia); Hicks, Rodney J. [The University of Melbourne, The Sir Peter MacCallum Department of Oncology, Melbourne (Australia); The Peter MacCallum Cancer Centre, Cancer Imaging, Melbourne, VIC (Australia)

    2017-08-15

    The treatment of melanoma has been revolutionised in recent years by advances in the understanding of the genomic landscape of this disease, which has led to the development of new targeted therapeutic agents, and the ability to therapeutically manipulate the immune system through inhibition of cancer cell-T-cell interactions that prevent an adaptive immune response. While these therapeutic interventions have dramatically improved the prospects of survival for patients with advanced melanoma, they bring significant complexity to the interpretation of therapeutic response because their mechanisms and temporal profile of response vary considerably. In this review, we discuss the mode of action of these emerging therapies and their toxicities to provide a framework for the use of FDG PET/CT in therapeutic response assessment. We propose that the greatest utility of PET in assessment of response to agents that abrogate signalling related to BRAF mutation is for early assessment of resistance, while in anti-CTLA4 therapy, immunological flare can compromise early assessment of response but can identify potentially life-threatening autoimmune reactions. For anti-PD1/PDL1 therapy, the role of FDG PET/CT is more akin to its use in other solid malignancies undergoing treatment with conventional chemotherapy. However, further research is required to optimise the timing of scans and response criteria in this disease. (orig.)

  11. After Imagining/ Après l'imaginer: Imaginations

    Directory of Open Access Journals (Sweden)

    Managing Editors

    2010-12-01

    Full Text Available We welcome you to Imaginations: Journal of Cross-Cultural Image Studies / Revue d’études interculturelles de l’image, an open-access online peer-reviewed journal born out of research and developments in cross-cultural and intersecting epistemological fields that have at their root a determined focus on the role and power of the image in contemporary culture and in cultural communications. Nous vous souhaitons la bienvenue à Imaginations: Journal of Cross-Cultural Image Studies / Revue d’études interculturelles de l’image, un journal en ligne à accès libre dont les contributions sont préalablement soumises à un comité de révision par les pairs. Cette publication est le fruit d’un vif intérêt pour la recherche et la pratique au croisement de multiples champs épistémologiques et interculturels autour du rôle et de la puissance de l’image dans la société et les média contemporains.

  12. Synthesis, biological evaluation, and baboon PET imaging of the potential adrenal imaging agent cholesteryl-p-[{sup 18}f]fluorobenzoate

    Energy Technology Data Exchange (ETDEWEB)

    Jonson, Stephanie D.; Welch, Michael J. E-mail: welch@mirlink.wustl.edu

    1999-01-01

    Cholesteryl-p-[{sup 18}F]fluorobenzoate ([{sup 18}F]CFB) was investigated as a potential adrenal positron emission tomography (PET) imaging agent for the diagnostic imaging of adrenal disorders. We describe the synthesis, biodistribution, adrenal autoradiography, and baboon PET imaging of [{sup 18}F]CFB. The synthesis of [{sup 18}F]CFB was facilitated by the use of a specially designed microwave cavity that was instrumental in effecting 70-83% incorporation of fluorine-18 in 60 s via [{sup 18}F]fluoro-for-nitro exchange. Tissue distribution studies in mature female Sprague-Dawley rats showed good accumulation of [{sup 18}F]CFB in the steroid-secreting tissues, adrenals and ovaries, at 1 h postinjection. The effectiveness of [{sup 18}F]CFB to accumulate in diseased adrenals was shown through biodistribution studies in hypolipidemic rats, which showed a greater than threefold increase in adrenal uptake at 1 h and increased adrenal/liver and adrenal/kidney ratios. Analysis of the metabolites at 1 h in the blood, adrenals, spleen, and ovaries of hypolipidemic and control rats showed the intact tracer representing greater than 86%, 93%, 92%, and 82% of the accumulated activity, respectively. [{sup 18}F]CFB was confirmed to selectively accumulate in the adrenal cortex versus the adrenal medulla by autoradiography. Normal baboon PET imaging with [{sup 18}F]CFB effectively showed adrenal localization as early as 15 min after injection of the tracer, with enhanced adrenal contrast seen at 60-70 min. These results suggest that [{sup 18}F]CFB may be useful as an adrenal PET imaging agent for assessing adrenal disorders.

  13. Imagining the Future University

    DEFF Research Database (Denmark)

    Bengtsen, Søren Smedegaard; Barnett, Ronald

    'Imagining the Future University' is a special issue in the journal Philosophy and Theory in Higher Education, published by Peter Lang. Editor in Chief of the journal is John Petrovic, University of Alabama. The speciale issue is edited by Søren Bengtsen and Ronald Barnett.......'Imagining the Future University' is a special issue in the journal Philosophy and Theory in Higher Education, published by Peter Lang. Editor in Chief of the journal is John Petrovic, University of Alabama. The speciale issue is edited by Søren Bengtsen and Ronald Barnett....

  14. Physics imagination and reality

    CERN Document Server

    Wallace, Philip Russell

    1991-01-01

    Physics: Imagination and Reality introduces the reader to major ideas and the conceptual structure of modern physics, by tracing its development from the introduction of fields into physics by Faraday and Maxwell in the last century. Because the approach is historical, the book provides a comprehensive overview of the subjects. It should appeal to anyone interested in a basic understanding of the contemporary physicists view of the physical world. It avoids all but the simplest mathematics and presents ideas and concepts in everyday language.Physics: Imagination and Reality attempts to provide

  15. Imagine A Collective Landscape

    Directory of Open Access Journals (Sweden)

    Manuela Silvia Campanini

    2010-03-01

    Full Text Available Iceland plays a key role in the circumpolar context. The research investigates the fields of both the icelandic cultural landscape perception and the icelandic cultural identity. It considers the book Ultima thule; or, a summer in Iceland and Ólafur Elíasson art works as two sides of a same medal: the Iceland on the brain concept (F. Burton. The transition from a cultural identity to a collective landscape identity is investigated analysing Imagine J. Lennon's song which inspired Yõko Ono's work art titled Imagine Peace Tower.

  16. Seeing Imagination as Resistance and Resistance as Imagination

    DEFF Research Database (Denmark)

    Tateo, Luca

    2017-01-01

    features that enable humans to deal with uncertainty and change. Imagination is related to the creation of Gegenstand from non-existing objects. Imagination is also the faculty to go beyond problems in order to solve them. That is the reason why imagination is so dangerous for every dictatorship....

  17. Teaching the Handicapped Imagination.

    Science.gov (United States)

    Sloane, Sarah

    1983-01-01

    The article describes exercises in drama and creative writing to broaden the imaginations of visually handicapped children through stories and poems with a nonvisual imagery. Examples of stories and poems written specifically for the visually handicapped are included. (Author/CL)

  18. Imagined futures, present lives

    DEFF Research Database (Denmark)

    Dalsgaard, Anne Line; Wildermuth, Norbert

    2006-01-01

    is discussed centrally in this attempt to contribute to an empirically grounded understanding of the role that media play for youth in their striving to ‘find a place in life'. In the empirical context presented in the article, imaginations, expanded and circulated by a globalized media circuit...

  19. Dosimetry and stability studies of the boron neutron capture therapy agent F-BPA-Fr using PET and MRI

    Science.gov (United States)

    Dyke, Jonathan Paul

    The treatment of deep seated brain tumors such as glioblastoma Multiforme has been unsuccessful for many patients. Surgical debulking, chemotherapy and standard radiotherapy have met with limited success. Boron neutron capture therapy offers a binary mode brachytherapy based on the following capture reaction that may provide an innovative alternative to standard forms of treatment:10B + n /to/ 11B /to 7Li + 4He + 2.31 MeVBoron is chemically attached to a tumor binding compound creating a non-toxic neutron absorber. A dose of epithermal neutrons provides the catalyst to produce the lithium and alpha particles which destroy any tissue within a length of one cell diameter from the boron compound. This dissertation uses 19F-MRI and 18F-PET to provide answers to the localization and biodistribution questions that arise in such a treatment modality. Practical patient dosimetry and actual treatment planning using the PET data is also examined. Finally, theoretical work done in the areas of compartmental modelling dealing with pharmacokinetic uptake of the PET radiotracer and dose analysis in microdosimetry is also presented.

  20. Imagination in radiotherapy

    International Nuclear Information System (INIS)

    Pourrez, A.; Truc, G.; Santona, M.; Crehange, G.; Peignaux, K.; Martin, E.; Maingon, P.

    2010-01-01

    Based on a questionnaire given to the patients of a radiotherapy department and to the personnel of a centre of struggle against cancer, the study aimed at revealing imagination and representations about such an advanced medical technology, radio-physics and radioactivity. The patients and personnel were asked to answer the questionnaire with free words, images, or by expressing their own intimate or cultural visions of this environment. Implications on patients' anguish are foreseen. Short communication

  1. Isolation of the highly pathogenic and zoonotic agent Burkholderia pseudomallei from a pet green Iguana in Prague, Czech Republic.

    Science.gov (United States)

    Elschner, Mandy C; Hnizdo, Jan; Stamm, Ivonne; El-Adawy, Hosny; Mertens, Katja; Melzer, Falk

    2014-11-28

    Melioidosis caused by Burkholderia (B.) pseudomallei is an endemic zoonotic disease mainly reported from northern Australia and Southeast Asia. In Europe, cases of human melioidosis have been reported only from patients travelling to endemic regions. Besides humans, B. pseudomallei has a very broad host range in domestic and wild animals. There are some reports about importation of B. pseudomallei-infected animals from endemic areas into Europe. The present report describes the first case of B. pseudomallei infection of a pet iguana in Europe. In a 5-year-old pet Iguana iguana living in a private household in Prague, Czech Republic, B. pseudomallei was isolated from pus of an abscess. The isolate VB976100 was identified by Vitek®2, MALDI-TOF mass spectrometry and polymerase chain reaction as B. pseudomallei. The molecular typing resulted in multi-locus sequence type 436 hitherto, which has been found only once worldwide in a B. pseudomallei strain isolated in the USA and originating from Guatemala. The identification as internal transcribed spacer type G indicates a close relatedness to strains mainly isolated in the Western Hemisphere. These findings support the hypothesis that the iguana became infected in this region or in a breeding facility through contact to other infected animals. The present case highlights the risk of importation of the highly pathogenic and zoonotic B. pseudomallei into non-endemic regions through animal trade. Therefore, veterinarians treating animals from these areas and physicians examining patients owning such animals should include melioidosis in differential diagnosis whenever specific symptoms appear. Furthermore, veterinary authorities responsible for supervision of traders and pet shops should be aware of this risk of zoonotic transmission.

  2. Biodistribution and human dosimetry estimation of fluoro-L-DOPA as PET imaging agent of dopaminergic nerve transmitter systems

    International Nuclear Information System (INIS)

    Tang Ganghua; Wang Mingfang; Luo Lei; Gan Manquan; Tang Xiaolan; Zhang Lan; Wang Yongxian

    2002-01-01

    Objective: To investigate the biodistribution and human dosimetry estimation of 6-[ 18 F] Fluoro-L-DOPA (FDOPA). Methods: Biodistribution of FDOPA in normal rats and brain of hemi-Parkinsonism rats were determined. Human dosimetry estimation was performed by MIRD method based on the rats biodistribution data. Results: Biodistributions in normal rats showed high uptake in kidney, blood, striatum and hippocampi, fast clearance of radioactivity from kidney and blood, longer retain time in striatum and hippocampi, and higher striatum to cerebellum and striatum to cortex ratio. FDOPA uptake, striatum to cerebellum and striatum to cortex ratio in the lesioned side of hemi-Parkinsonism rats (P 2 to 2.3 x 10 -2 mGy/MBq and the effective dose in humans was estimated to be 2.05 x 10 -2 mSv/MBq after injection of FDOPA based on rats biodistribution data, which were consistent with those reported by literature on the whole. Conclusion: Human radiation dosimetry of FDOPA and other PET tracers can be estimated based on animals biodistribution data. The synthetic FDOPA is safe and efficient and can be used in animals, human and PD patients PET studies

  3. Individual differences in imagination inflation.

    Science.gov (United States)

    Heaps, C; Nash, M

    1999-06-01

    Garry, Manning, Loftus, and Sherman (1996) found that when adult subjects imagined childhood events, these events were subsequentlyjudged as more likely to have occurred than were not-imagined events. The authors termed this effect imagination inflation. We replicated the effect, using a novel set of Life Events Inventory events. Further, we tested whether the effect is related to four subject characteristics possibly associated with false memory creation. The extent to which subjects inflated judged likelihood following imagined events was associated with indices of hypnotic suggestibility and dissociativity, but not with vividness of imagery or interrogative suggestibility. Results suggest that imagination plays a role in subsequent likelihood judgments regarding childhood events, and that some individuals are more likely than others to experience imagination inflation.

  4. Imagination in Creative Design

    DEFF Research Database (Denmark)

    Wiltschnig, Stefan

    2011-01-01

    This paper unpacks the notion of imagination presented in the I5-system of knowledge creation along several theoretical contributions and process models from “knowledge science”, creativity research and design studies. It aims at conceptual clarification and integration around the key notion...... of “insight moments” across various levels of abstraction from system perspectives through foci on groups and individuals to mental activity. This work is meant to serve as a conceptual foundation for micro-analyses of in-vivo data of creative design processes based on protocols of participatory ethnographic...

  5. Imagination in Creative Design

    DEFF Research Database (Denmark)

    Wiltschnig, Stefan

    2013-01-01

    This paper unpacks the notion of imagination presented in the I5-system of knowledge creation along several theoretical contributions and process models from “knowledge science”, creativity research and design studies. It aims at conceptual clarification and integration around the key notion...... of “insight moments” across various levels of abstraction from system perspectives through foci on groups and individuals to mental activity. This work is meant to serve as a conceptual foundation for micro-analyses of in-vivo data of creative design processes based on protocols of participatory ethnographic...

  6. Mathematics for the imagination

    CERN Document Server

    Higgins, Peter

    2002-01-01

    Mathematics for the Imagination provides an accessible and entertaining investigation into mathematical problems in the world around us. From world navigation, family trees, and calendars to patterns, tessellations, and number tricks, this informative and fun new book helps you to understand the maths behind real-life questions and rediscover your arithmetical mind.This is a follow-up to the popular Mathematics for the Curious, Peter Higgins's first investigation into real-life mathematical problems.A highly involving book which encourages the reader to enter into the spirit of mathematical ex

  7. Imagining Geographies, Mapping Identities

    Directory of Open Access Journals (Sweden)

    Matthew Graves

    2015-03-01

    Full Text Available The ambition of this issue of Portal is to reach across the methodological boundaries of history, politics, literature and geography to apply their complementary perspectives to the study of identity and its relation to space and place, an aim that involves attempting to identify the many different ways the notoriously slippery concepts of identity and geography may intersect. For this issue we have selected articles that cast a fresh perspective on two areas where identity and geography intersect: the construction of identity through the imaginative recreation of place in literature: Mapping Literary Spaces; and the study of the shifting relationships of centre and periphery, exclusion and inclusion in urban settings and geopolitical confrontations: Social and Political Peripheries. Gerard Toal has written that geography is not a noun but a verb: it does not describe what space is but studies what we do with space, imaginatively and politically. The articles in this issue illustrate the exercise of the literary and political imagination and the role of materiality and memory in the creation of geographic representation. They show too a new awareness of the centrality of space in the constitution of identities, and the need for a new geocritical reading of its discourse, as the interrelations of place and community are played out on the many scales of social and political life, from the local to the global.   The special issue is organised thus: Introduction Matthew Graves (Aix-Marseille University & Liz Rechniewski (Sydney University: “Imagining Geographies, Mapping Identities.” I. Mapping Literary Spaces - Isabelle Avila (University of Paris XIII, "Les Cartes de l'Afrique au XIXe siècle et Joseph Conrad : Perceptions d'une Révolution Cartographique." - Daniela Rogobete (University of Craiova, "Global vs Glocal: Dimensions of the post-1981 Indian English Novel." II. Social and Political Peripheries - Elizabeth Rechniewski (Sydney

  8. Development of a PET Prostate-Specific Membrane Antigen Imaging Agent: Preclinical Translation for Future Clinical Application

    Science.gov (United States)

    2017-10-01

    are those of the author(s) and should not be construed as an official Department of the Army position, policy or decision unless so designated by...phase 0) application to the FDA by the end of the funding period. The small molecule imaging agents under study home to prostate specific membrane...funding period. The small molecule imaging agents under study home to prostate specific membrane antigen (PSMA) that is prevalent on a majority of

  9. Development of a new chemical introduction process for hours living radioisotope and it's application for PET imaging agent

    International Nuclear Information System (INIS)

    Kurihara, Masaaki

    2004-01-01

    A new chemical introduction process of fluorine-18, 18 F was developed using solid phase synthesis technique, instead of a conventional liquid phase synthesis. Separation for a plenty of non-reaction compound was difficult in the liquid phase synthesis technique. Precursor compound reacted on the surface of solid phase (beads). Labeled compound with 18 F could be separated from the solid surface by reaction of fluoride reagent. A fundamental fluoric reaction was developed with the solid phase process. Sulfonyl chloride, polymer-bound 1 was used as a solid phase carrier of the precursor. The 18 F-FDG, which are replaced a hydroxyl group in D-glucose with 18 F, were used most frequently as a cancer marker in positron computed tomography (PET). Synthesis of the 18 F-FDG was investigated by the solid phase technique. (M. Suetake)

  10. Characterization of 4-[18F]-ADAM as an imaging agent for SERT in non-human primate brain using PET: a dynamic study

    International Nuclear Information System (INIS)

    Chen, Yu-An; Huang, Wen-Sheng; Lin, Yaoh-Shiang; Cheng, Cheng-Yi; Liu, Ren-Shyan; Wang, Shyh-Jen; Li, I-Hsun; Huang, San-Yuan; Shiue, Chyng-Yann; Chen, Cheng-Yu; Ma, Kuo-Hsing

    2012-01-01

    Introduction: Serotonin transporter (SERT) has been associated with many psychiatric diseases. This study investigated the biodistribution of a serotonin transporter imaging agent, N,N-dimethyl-2-(2-amino-4- 18 F-fluorophenylthio)benzylamine (4-[ 18 F]-ADAM), in nonhuman primate brain using positron emission tomography (PET). Methods: Six and four Macaca cyclopis monkeys were used to determine the transit time (i.e., time necessary to reach biodistribution equilibrium) and the reproducibility of 4-[ 18 F]-ADAM biodistribution in the brain, respectively. The sensitivity and specificity of 4-[ 18 F]-ADAM binding to SERT were evaluated in one monkey challenged with different doses of fluoxetine and one monkey treated with 3,4-methylendioxymethamphetamine (MDMA). Dynamic PET imaging was performed for 3 h after 4-[ 18 F]-ADAM intravenous bolus injection. The specific uptake ratios (SURs) in the midbrain (MB), thalamus (TH), striatum (ST) and frontal cortex (FC) were calculated. Results: The distribution of 4-[ 18 F]-ADAM reached equilibrium 120–150 min after injection. The mean SURs were 2.49±0.13 in MB, 1.59±0.17 in TH, 1.35±0.06 in ST and 0.34±0.03 in FC, and the minimum variability was shown 120–150 min after 4-[ 18 F]-ADAM injection. Using SURs and intraclass coefficient of correlation, the test/retest variability was under 8% and above 0.8, respectively, in SERT-rich areas. Challenge with fluoxetin (0.75–2 mg) dose-dependently inhibited the SURs in various brain regions. 4-[ 18 F]-ADAM binding was markedly reduced in the brain of an MDMA-treated monkey compared to that in brains of normal controls. Conclusion: 4-[ 18 F]-ADAM appears to be a highly selective radioligand for imaging SERT in monkey brain.

  11. Analysing Children's Drawings: Applied Imagination

    Science.gov (United States)

    Bland, Derek

    2012-01-01

    This article centres on a research project in which freehand drawings provided a richly creative and colourful data source of children's imagined, ideal learning environments. Issues concerning the analysis of the visual data are discussed, in particular, how imaginative content was analysed and how the analytical process was dependent on an…

  12. The Imagined Desert

    Directory of Open Access Journals (Sweden)

    Tom Drahos

    2013-10-01

    Full Text Available The following analysis of the Australian Outback as an imagined space is informed by theories describing a separation from the objective physical world and the mapping of its representative double through language, and draws upon a reading of the function of landscape in three fictions; Joseph Conrad’s novella Heart of Darkness (1899, Greg Mclean’s 2005 horror film Wolf Creek and Ted Kotcheff’s 1971 cinematic adaptation of Kenneth Cook’s novel Wake in Fright2. I would like to consider the Outback as a culturally produced text, and compare the function of this landscape as a cultural ‘reality’ to the function of landscape in literary and cinematic fiction.

  13. A Hybrid Imagination

    DEFF Research Database (Denmark)

    Jamison, Andrew; Christensen, Steen Hyldgaard; Botin, Lars

    “hubris” that is so much taken for granted in contemporary science and engineering discourses and practices with a sense of cooperation and social responsibility. The book portrays the history of science and technology as an underlying tension between hubris – literally the ambition to “play god...... an alternative approach, devoting special attention to the role played by social and cultural movements in the making of science and technology. They show how social and cultural movements, from the Renaissance of the late 15th century to the environmental and global justice movements of our time, have provided......” on the part of many a scientist and engineer and neglect the consequences - and a hybrid imagination, connecting scientific “facts” and technological “artifacts” with cultural understanding. The book concludes with chapters on the recent transformations in the modes of scientific and technological production...

  14. Imagined futures, present lives

    DEFF Research Database (Denmark)

    Dalsgaard, Anne Line; Wildermuth, Norbert

    2006-01-01

    The article is focused thematically on the uses and meanings of media for (some) young people in Recife, a million-inhabitant city in the northeast of Brazil. The article brings together the perspective of Anne Line Dalsgaard, a long-term anthropological field researcher who is familiar with the ......The article is focused thematically on the uses and meanings of media for (some) young people in Recife, a million-inhabitant city in the northeast of Brazil. The article brings together the perspective of Anne Line Dalsgaard, a long-term anthropological field researcher who is familiar...... is discussed centrally in this attempt to contribute to an empirically grounded understanding of the role that media play for youth in their striving to ‘find a place in life'. In the empirical context presented in the article, imaginations, expanded and circulated by a globalized media circuit...

  15. Synthesis of [18F]-labelled nebivolol as a β1-adrenergic receptor antagonist for PET imaging agent

    International Nuclear Information System (INIS)

    Kim, Taek Soo; Park, Jeong Hoon; Lee, Jun Young; Yang, Seung Dae; Chang, Dong Jo

    2017-01-01

    Selective β 1 -agonist and antagonists are used for the treatment of cardiac diseases including congestive heart failure, angina pectoris and arrhythmia. Selective β 1 -antagonists including nebivolol have high binding affinity on β 1 -adrenergic receptor, not β 2 -receptor mainly expressed in smooth muscle. Nebivolol is one of most selective β 1 -blockers in clinically used β 1 - blockers including atenolol and bisoprolol. We tried to develop clinically useful cardiac PET tracers using a selective β 1 -blocker. Nebivolol is C 2 -symmetric and has two chromane moiety with a secondary amino alcohol and aromatic fluorine. We adopted the general synthetic strategy using epoxide ring opening reaction. Unlike formal synthesis of nebivolol, we prepared two chromane building blocks with fluorine and iodine which was transformed to diaryliodonium salt for labelling of 18 F. Two epoxide building blocks were readily prepared from commercially available chromene carboxylic acids (1, 8). Then, the amino alcohol building block (15) was prepared by ammonolysis of epoxide (14) followed by coupling reaction with the other building block, epoxide (7). Diaryliodonium salt, a precursor for 18 F-aromatic substitution, was synthesized in moderate yield which was readily subjected to 18 F-aromatic substitution to give 18 F-labelled nebivolol

  16. The Incredibly Shrinking World of Imagination.

    Science.gov (United States)

    Kassem, Lou

    1992-01-01

    Suggests that children's imaginations are not shrinking. Discusses seven ways in which English teachers, librarians, publishers, and authors have used adolescent literature in creative and imaginative ways. (RS)

  17. Cardiac retention of PET neuronal imaging agent LMI1195 in different species: Impact of norepinephrine uptake-1 and -2 transporters

    International Nuclear Information System (INIS)

    Yu, Ming; Bozek, Jody; Kagan, Mikhail; Guaraldi, Mary; Silva, Paula; Azure, Michael; Onthank, David; Robinson, Simon P.

    2013-01-01

    Introduction: Released sympathetic neurotransmitter norepinephrine (NE) in the heart is cleared by neuronal uptake-1 and extraneuronal uptake-2 transporters. Cardiac uptake-1 and -2 expression varies among species, but the uptake-1 is the primary transporter in humans. LMI1195 is an NE analog labeled with 18 F for PET evaluation of cardiac neuronal function. This study investigated the impact of cardiac neuronal uptake-1 associated with different species on LMI1195 heart uptake. Methods: Cardiac uptake-1 was blocked by desipramine, a selective uptake-1 inhibitor, and sympathetic neuronal denervation was induced by 6-hydroxydopamine, a neurotoxin, in rats, rabbits and nonhuman primates (NHP). Tissue biodistribution and cardiac imaging of LMI1195 and 123 I-metaiodobenzylguanidine (MIBG) were performed. Results: In rats, uptake-1 blockade did not alter LMI1195 heart uptake compared to the control at 60-min post injection [1.41 ± 0.07 vs. 1.47 ± 0.23 % injected dose per gram tissue (%ID/g)]. In contrast, LMI1195 heart uptake was reduced by 80% in uptake-1 blocked rabbits. In sympathetically denervated rats, LMI1195 heart uptake was similar to the control (2.18 ± 0.40 vs. 2.58 ± 0.76 %ID/g). However, the uptake decreased by 79% in denervated rabbits. Similar results were found in MIBG heart uptake in rats and rabbits with uptake-1 blockade. Consistently, LMI1195 cardiac imaging showed comparable myocardial activity in uptake-1 blocked or sympathetically denervated rats to the control, but marked activity reduction in uptake-1 blocked or denervated rabbits and NHPs. Conclusions: LMI1195 is retained in the heart of rabbits and NHPs primarily via the neuronal uptake-1 with high selectivity and can be used for evaluation of cardiac sympathetic denervation. Similar to the human, the neuronal uptake-1 is the dominant transporter for cardiac retention of NE analogs in rabbits and NHPs, but not in rats

  18. Biodistribution and radiation dosimetry of 18F-CP-18, a potential apoptosis imaging agent, as determined from PET/CT scans in healthy volunteers.

    Science.gov (United States)

    Doss, Mohan; Kolb, Hartmuth C; Walsh, Joseph C; Mocharla, Vani; Fan, Hong; Chaudhary, Ashok; Zhu, Zhihong; Alpaugh, R Katherine; Lango, Miriam N; Yu, Jian Q

    2013-12-01

    (18)F-CP-18, or (18S,21S,24S,27S,30S)-27-(2-carboxyethyl)-21-(carboxymethyl)-30-((2S,3R,4R,5R,6S)-6-((2-(4-(3-F18-fluoropropyl)-1H-1,2,3-triazol-1-yl)acetamido)methyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxamido)-24-isopropyl-18-methyl-17,20,23,26,29-pentaoxo-4,7,10,13-tetraoxa-16,19,22,25,28-pentaazadotriacontane-1,32-dioic acid, is being evaluated as a tissue apoptosis marker for PET imaging. The purpose of this study was to determine the biodistribution and estimate the normal-organ radiation-absorbed doses and effective dose from (18)F-CP-18. Successive whole-body PET/CT scans were obtained at approximately 7, 45, 90, 130, and 170 min after intravenous injection of (18)F-CP-18 in 7 healthy human volunteers. Blood samples and urine were collected between the PET/CT scans, and the biostability of (18)F-CP-18 was assessed using high-performance liquid chromatography. The PET scans were analyzed to determine the radiotracer uptake in different organs. OLINDA/EXM software was used to calculate human radiation doses based on the biodistribution of the tracer. (18)F-CP-18 was 54% intact in human blood at 135 min after injection. The tracer cleared rapidly from the blood pool with a half-life of approximately 30 min. Relatively high (18)F-CP-18 uptake was observed in the kidneys and bladder, with diffuse uptake in the liver and heart. The mean standardized uptake values (SUVs) in the bladder, kidneys, heart, and liver at around 50 min after injection were approximately 65, 6, 1.5, and 1.5, respectively. The calculated effective dose was 38 ± 4 μSv/MBq, with the urinary bladder wall having the highest absorbed dose at 536 ± 61 μGy/MBq using a 4.8-h bladder-voiding interval for the male phantom. For a 1-h voiding interval, these doses were reduced to 15 ± 2 μSv/MBq and 142 ± 15 μGy/MBq, respectively. For a typical injected activity of 555 MBq, the effective dose would be 21.1 ± 2.2 mSv for the 4.8-h interval, reduced to 8.3 ± 1.1 mSv for the 1-h interval

  19. Bifunctional Agents for MRI, PET and Fluorescence Imaging and Study of Nanoparticles Formed from Water Oxidation Catalysts /

    OpenAIRE

    Abadjian, Marie-Caline Z.

    2014-01-01

    The work is divided into four parts : (1) MRI contrast agents are designed to enhance T₁ relaxivity by coupling them to dendrimers, the precise structure of which can be controlled through synthesis. Cyclen is used as a starting scaffold for the synthesis of bifunctional Gd-DOTA and Gd- DOTMA analogues. One unique side chain on the macrocycle contains an azide moiety that can be clicked to an alkyne- containing core, making a first-generation dendrimer with the potential to improve MRI effici...

  20. Imagine the Universe!

    Science.gov (United States)

    White, N.

    2003-01-01

    Welcome to the 2004 edition of the education CD from the Laboratory for High Energy Astrophysics at NASA Goddard Space Flight Center. We hope that you will find it to be an exciting and fun learning experience. We have tried very hard to make this CD as user-friendly as possible and along the way we have discovered some things that every user may need to know. Please read the README file found on the CD if you have any questions or problems using the disk. Then, after that, if you still have problems, email us at itu@athena.gsfc.nasa.gov. We will be happy to help you 'get going'! Below are links to all of the sites included on the CD. You will also find the addresses for the on-line version of each of these sites. If you have a good Internet connection available, we recommend that you view the sites on-line. There you will find the latest updated information, interactive activities, and active links to other sites. Included on the disk are: Imagine The Universe! This site is dedicated to a discussion about our Universe... what we know about it, how it is evolving, and the kinds of objects and phenomena it contains. Emphasizing the X-ray and gamma-ray parts of the electromagnetic spectrum, it also discusses how scientists know what they know, what mysteries remain, and how the answers to remaining mysteries may one day be found. Lots of movies, quizzes, and a special section for educators. Geared for ages 14 and up. This site can be viewed on-line at http://imagine.gsfc.nasa.gov/. StarChild: A learning center for young astronomers The 1998 Webby Award Winner for Best Education Website, StarChild is aimed at ages 4-14. It contains easy-to-understand information about our Solar System, the Universe, and space exploration. There are also activities, songs, movies, and puzzles! This site can be viewed on-line at http://starchild.gsfc.nasa.gov/. Astronomy Picture of the Day APOD offers a new astronomical image and caption each calendar day. We have captured the year 2003

  1. Simple synthesis of carbon-11-labeled chromen-4-one derivatives as new potential PET agents for imaging of DNA-dependent protein kinase (DNA-PK) in cancer

    International Nuclear Information System (INIS)

    Gao, Mingzhang; Wang, Min; Miller, Kathy D.; Zheng, Qi-Huang

    2012-01-01

    Carbon-11-labeled chromen-4-one derivatives were synthesized as new potential PET agents for imaging of DNA repair enzyme DNA-dependent protein kinase (DNA-PK) in cancer. The target tracers, X-[ 11 C]methoxy-2-morpholino-4H-chromen-4-ones (X=8, 7, 6, 5; [ 11 C]4a–d), were prepared from their corresponding precursors, X-hydroxy-2-morpholino-4H-chromen-4-ones (X=8, 7, 6, 5; 5a–d), with [ 11 C]CH 3 OTf through O-[ 11 C]methylation and isolated by a simplified solid-phase extraction (SPE) method using a C-18 Sep-Pak Plus cartridge. The radiochemical yields decay corrected to end of bombardment (EOB), from [ 11 C]CO 2 , were 40–60%. The specific activity at end of synthesis (EOS) was 185–370 GBq/μmol. - Highlights: ► New chromen-4-one derivatives were synthesized. ► New carbon-11-labeled chromen-4-one derivatives were synthesized. ► Simple solid-phase extraction (SPE) method was employed in radiosynthesis.

  2. Facile synthesis of new carbon-11 labeled conformationally restricted rivastigmine analogues as potential PET agents for imaging AChE and BChE enzymes

    International Nuclear Information System (INIS)

    Wang Min; Wang Jiquan; Gao Mingzhang; Zheng Qihuang

    2008-01-01

    Rivastigmine is a newer-generation inhibitor with a dual inhibitory action on both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes, and is used for the treatment of AChE- and BChE-related diseases such as brain Alzheimer's disease and cardiovascular disease. New carbon-11 labeled conformationally restricted rivastigmine analogues radiolabeled quaternary ammonium triflate salts, (3aR,9bS)-1-[ 11 C]methyl-1-methyl-6-(methylcarbamoyloxy)-2,3,3a,4,5, 9b-hexahy dro-1H-benzo[g]indolium triflate ([ 11 C]8) and (3aR,9bS)-1-[ 11 C]methyl-1-methyl-6-(heptylcarbamoyloxy)-2,3,3a,4,5, 9b-hexahy dro-1H-benzo[g]indolium triflate ([ 11 C]9), were designed and synthesized as potential positron emission tomography (PET) agents for imaging AChE and BChE enzymes. The appropriate precursors were labeled with [ 11 C]CH 3 OTf through N-[ 11 C]methylation, and the target tracers were isolated by solid-phase extraction (SPE) using a cation-exchange CM Sep-Pak cartridge in 40-50% radiochemical yields decay corrected to end of bombardment (EOB), 15-20 min overall synthesis time, and 148-222 GBq/μmol specific activity at EOB

  3. Parental influence on adolescents' imagination.

    Science.gov (United States)

    Rabinowitz, A; Engelberg, D

    1984-09-01

    It was hypothesized that a permissive democratic parental attitude towards childrearing and favorable accepting attitude towards children's imagination are conducive to the development of their adolescent children's imaginative ability. It was also hypothesized that the mothers' role is more crucial than that of the fathers. The subjects were 104 adolescent Israeli boys and girls and their parents. The subjects were administered four scales of the Imaginal Processes Inventory and the Children's Report of Parental Behavior Inventory. The parents filled out a questionnaire devised to study their attitude to children's imagination. The first two hypotheses were not confirmed. The data point in the opposite direction as regards the first hypothesis. There was partial conformation for the third hypothesis. The data were also discussed in relation to healthy and neurotic daydreaming.

  4. 68Ga-THP-PSMA: A PET Imaging Agent for Prostate Cancer Offering Rapid, Room-Temperature, 1-Step Kit-Based Radiolabeling.

    Science.gov (United States)

    Young, Jennifer D; Abbate, Vincenzo; Imberti, Cinzia; Meszaros, Levente K; Ma, Michelle T; Terry, Samantha Y A; Hider, Robert C; Mullen, Greg E; Blower, Philip J

    2017-08-01

    The clinical impact and accessibility of 68 Ga tracers for the prostate-specific membrane antigen (PSMA) and other targets would be greatly enhanced by the availability of a simple, 1-step kit-based labeling process. Radiopharmacy staff are accustomed to such procedures in the daily preparation of 99m Tc radiopharmaceuticals. Currently, chelating agents used in 68 Ga radiopharmaceuticals do not meet this ideal. The aim of this study was to develop and evaluate preclinically a 68 Ga radiotracer for imaging PSMA expression that could be radiolabeled simply by addition of 68 Ga generator eluate to a cold kit. Methods: A conjugate of a tris(hydroxypyridinone) (THP) chelator with the established urea-based PSMA inhibitor was synthesized and radiolabeled with 68 Ga by adding generator eluate directly to a vial containing the cold precursors THP-PSMA and sodium bicarbonate, with no further manipulation. It was analyzed after 5 min by instant thin-layer chromatography and high-performance liquid chromatography. The product was subjected to in vitro studies to determine PSMA affinity using PSMA-expressing DU145-PSMA cells, with their nonexpressing analog DU145 as a control. In vivo PET imaging and ex vivo biodistribution studies were performed in mice bearing xenografts of the same cell lines, comparing 68 Ga-THP-PSMA with 68 Ga-HBED-CC-PSMA. Results: Radiolabeling was complete (>95%) within 5 min at room temperature, showing a single radioactive species by high-performance liquid chromatography that was stable in human serum for more than 6 h and showed specific binding to PSMA-expressing cells (concentration giving 50% inhibition of 361 ± 60 nM). In vivo PET imaging showed specific uptake in PSMA-expressing tumors, reaching 5.6 ± 1.2 percentage injected dose per cubic centimeter at 40-60 min and rapid clearance from blood to kidney and bladder. The tumor uptake, biodistribution, and pharmacokinetics were not significantly different from those of 68 Ga

  5. School, Earth and Imagination

    Science.gov (United States)

    Merlini, Anna; Grieco, Giovanni; Oneta, Cristina

    2015-04-01

    Geology needs to be explained and narrated to the people, focusing on the goal of making that big change of mindset that will allow individuals and the entire community to tune into the timing and the ways in which the Earth evolves. In order to achieve these important goals it is necessary to educate children from an early age so that they learn to live an environmentally friendly life. With the project "School, Earth and imagination" we introduce, with a fun and new way, notions and topics in geological and environmental sciences in schools at all levels with the final goal of improving both knowledge and sensibility for these topics into the community. Through this project we start from the children (kindergarten and primary school, ages between 3 and 8 years) because they are the foundation of our society, and without foundations nothing can be built. The "School, Earth and imagination" project wants to give the children a real opportunity to approach reality and in general the surrounding environment, for the first time even before the traditional scholastic experience, with a scientific point of view, experimenting some basic physical concepts like temperature, weight, hardness and so on directly through their body. The project is structured and developed in modules that provide a high flexibility in order to meet needs and requirements of different schools in different situations. Each module is part of the journey of Mariolino, a character that represents a very curious child who introduces basic concepts associating them to geological processes. The Journey of Mariolino, as each module, follows an insistent scheme that starts from the presentation of the problem, follows with its discussion through direct questions and ends with experimentation of the hypotheses that children have proposed to validate the solution of the problem. Each module is independent and never ends without giving children a solution and is always structured with a practical activity

  6. Synthesis, characterization and in vivo evaluation of [(62)Zn]-benzo-δ-sultam complex as a possible pet imaging agent.

    Science.gov (United States)

    Ghandi, Mehdi; Feizi, Shahzad; Ziaie, Farhood; Fazaeli, Yousef; Notash, Behrooz

    2014-11-01

    The development of a new tracer based on the cyclic sulfonamides (sultams) was investigated. 3-(Methoxy-phenyl-methyl)-1,6-dimethyl-1H benzo[c][1,2] thiazine 2,2-dioxide (benzo-δ-sultam) was synthesized and characterized by elemental analysis, FT-IR spectroscopy and single crystal X-ray structure determination. The prepared cyclic sulfonamide was labeled with non-commercial (62)Zn radioisotope for fast in vivo targeting and Coincidence imaging purposes (radiochemical purity 97 % ITLC, 96 % HPLC, specific activity 20-23 GBq/mmol). In vivo biodistribution of the final complex was investigated in Sprague Dawley(®) rats bearing fibro sarcoma tumor after 2, 4 and 8 h post injection and compared with free Zn(+2) cation. Using instant paper chromatography method, the physicochemical properties of labeled compounds were found sufficiently stable in organic phases, e.g. a human serum, to be reliably used in bioapplications. The complex exhibited a rapid as well as high tumor uptake (tumor to blood ratio 4.38 and tumor to muscle ratio 9.63) resulting in an efficient tumor targeting agent.

  7. Quantitative kinetic analysis of PET amyloid imaging agents [11C]BF227 and [18F]FACT in human brain

    International Nuclear Information System (INIS)

    Shidahara, Miho; Watabe, Hiroshi; Tashiro, Manabu; Okamura, Nobuyuki; Furumoto, Shozo; Watanuki, Shoichi; Furukawa, Katsutoshi; Arakawa, Yuma; Funaki, Yoshihito; Iwata, Ren; Gonda, Kohsuke; Kudo, Yukitsuka; Arai, Hiroyuki; Ishiwata, Kiichi; Yanai, Kazuhiko

    2015-01-01

    Introduction: The purpose of this study was to compare two amyloid imaging agents, [ 11 C]BF227 and [ 18 F]FACT (derivative from [ 11 C]BF227) through quantitative pharmacokinetics analysis in human brain. Methods: Positron emission tomography studies were performed on six elderly healthy control (HC) subjects and seven probable Alzheimer’s disease (AD) patients with [ 11 C]BF227 and 10 HC subjects and 10 probable AD patients with [ 18 F]FACT. Data from nine regions of interest were analyzed by several approaches, namely non-linear least-squared fitting methods with arterial input functions (one-tissue compartment model(1TCM), two-tissue compartment model (2TCM)), Logan plot, and linearized methods with reference region (Reference Logan plot (RefLogan), MRTM0, MRTM2). We also evaluated SUV and SUVR for both tracers. The parameters estimated by several approaches were compared between two tracers for detectability of differences between HC and AD patients. Results: For [ 11 C]BF227, there were no significant difference of V T (2TCM, 1TCM) and SUV in all regions (Student t-test; p < 0.05) and significant differences in the DVRs (Logan, RefLogan, and MRTM2) and SUVRs in six neocortical regions (p < 0.05) between the HC and AD groups. For [ 18 F]FACT, significant differences in DVRs (RefLogan, MRTM0, and MRTM2) were observed in more than four neocortical regions between the HC and AD groups (p < 0.05), and the significant differences were found in SUVRs for two neocortical regions (inferior frontal coretex and lateral temporal coretex). Our results showed that both tracers can clearly distinguish between HC and AD groups although the pharmacokinetics and distribution patterns in brain for two tracers were substantially different. Conclusion: This study revealed that although the PET amyloid imaging agents [ 11 C]BF227 and [ 18 F]FACT have similar chemical and biological properties, they have different pharmacokinetics, and caution must be paid for usage of the

  8. Imagination in Japanese Educational Experiments.

    Science.gov (United States)

    Dorner, Robert; Kowalski, Ludwik

    1992-01-01

    In the K. Ikatura method used in Japan, an instructor describes an experiment with a number of possible outcomes. Students record and discuss their predictions; the experiment is performed and the results analyzed. This method creates constructive cognitive conflict and provides structure for imagination. (SK)

  9. Lung PET scan

    Science.gov (United States)

    ... Chest PET scan; Lung positron emission tomography; PET - chest; PET - lung; PET - tumor imaging; ... Grainger & Allison's Diagnostic Radiology: A Textbook of Medical Imaging . 6th ed. Philadelphia, ...

  10. The Relationships among Imagination, Future Imagination Tendency, and Future Time Perspective of Junior High School Students

    Science.gov (United States)

    Tsai, Min-Ying

    2015-01-01

    The main purpose of the study were to investigate the relationships among imagination, future imagination tendency, and future time perspective of junior high school students, then to explore the future time perspective which is predicted by background variables, imaginative qualities, and future imagination tendency. The subjects were 331 from…

  11. Exploration of Korean Students' Scientific Imagination Using the Scientific Imagination Inventory

    Science.gov (United States)

    Mun, Jiyeong; Mun, Kongju; Kim, Sung-Won

    2015-01-01

    This article reports on the study of the components of scientific imagination and describes the scales used to measure scientific imagination in Korean elementary and secondary students. In this study, we developed an inventory, which we call the Scientific Imagination Inventory (SII), in order to examine aspects of scientific imagination. We…

  12. Imagination First: Unlocking the Power of Possibility

    Science.gov (United States)

    Liu, Eric; Noppe-Brandon, Scott

    2011-01-01

    The best corporations know that innovative thinking is the only competitive advantage that cannot be outsourced. The best schools are those that create cultures of imagination. Now in paperback, "Imagination First" introduces a wide-variety of individuals who make a habit of imaginative thinking and creative action, offering a set of universal…

  13. On Major Developments in Preschoolers' Imagination

    Science.gov (United States)

    Diachenko, Olga M.

    2011-01-01

    The role of the imagination in adult thinking is to go beyond reality and to express generalised laws. The researcher's job is to specify the cultural tools that preschool children use in the development of their imagination. Previous research has identified two main stages in the development of imagination up until the age of six, a third stage…

  14. PET activation in basal ganglia disorders: Parkinson's disease and dystonia

    International Nuclear Information System (INIS)

    Ceballos-Baumann, A.O.; Boecker, H.; Conrad, B.

    1997-01-01

    This article reviews PET activation studies with performance of different motor paradigms (joy-stick movements, imagination of movement, writing) in patients with movement disorders. The focus will be on Parkinson's disease (PD) and dystonia. PET findings will be related to clinical and electrophysiological observations. PET activation studies before and after therapeutic interventions such as pallidotomy in Parkinson's disease and botulinum toxin in writer's cramp are described. The contribution of PET activation studies to the understanding of the pathophysiology of dystonia and PD is discussed. (orig.) [de

  15. Renegotiating religious imaginations through transformations of "banal religion" in Supernatural

    DEFF Research Database (Denmark)

    Petersen, Line Nybro

    2010-01-01

    implies long-term processes in which media play a role in cultural and social change. The theory of cognitive anthropology of religion allows us to understand how the series activates shared implicit knowledge of supernatural agents and events to evoke recognition and emotion; but by transforming...... applies these narrative devices, which heighten plausibility and familiarity, while simultaneously offering viewers a change in perspective, thus creating opportunities for viewers to renegotiate existing religious imaginations....

  16. Renegotiating religious imaginations through transformations of "banal religion" in Supernatural

    DEFF Research Database (Denmark)

    Petersen, Line Nybro

    implies long-term processes in which media play a role in cultural and social change. The theory of cognitive anthropology of religion allows us to understand how the series activates shared implicit knowledge of supernatural agents and events to evoke recognition and emotion; but by transforming...... applies these narrative devices, which heighten plausibility and familiarity, while simultaneously offering viewers a change in perspective, thus creating opportunities for viewers to renegotiate existing religious imaginations....

  17. Exploration of the impact of stereochemistry on the identification of the novel translocator protein PET imaging agent [18F]GE-180

    International Nuclear Information System (INIS)

    Chau, Wai-Fung; Black, Andrew M.A.; Clarke, Alan; Durrant, Clare; Gausemel, Ingvil; Khan, Imtiaz; Mantzilas, Dimitrios; Oulie, Inger; Rogstad, Astri; Trigg, William; Jones, Paul A.

    2015-01-01

    Introduction: The tricyclic indole compound, [ 18 F]GE-180 has been previously identified as a promising positron emission tomography (PET) imaging agent of the translocator protein (TSPO) with the potential to aid in the diagnosis, prognosis and therapy monitoring of degenerative neuroinflammatory conditions such as multiple sclerosis. [ 18 F]GE-180 was first identified and evaluated as a racemate, but subsequent evaluations of the resolved enantiomers have shown that the S-enantiomer has a higher affinity for TSPO and an improved in vivo biodistribution performance, in terms of higher uptake in specific brain regions and good clearance (as described previously). Here we describe the additional biological evaluations carried out to confirm the improved performance of the S-enantiomer and including experiments which have demonstrated the stability of the chiral centre to chemical and biological factors. Materials and Methods: GE-180 and the corresponding radiolabelling precursor were separated into single enantiomers using semi-preparative chiral supercritical fluid chromatography (SFC). A detailed comparison of the individual enantiomers and the racemate was carried out in a number of biological studies. TSPO binding affinity was assessed using a radioligand binding assay. Incubation with rat hepatic S9 fractions was used to monitor metabolic stability. In vivo biodistribution studies up to 60 min post injection (PI) in naïve rats were carried out to monitor uptake and clearance. Achiral and chiral in vivo metabolite detection methods were developed to assess the presence of metabolite/s in plasma and brain samples, with the chiral method also determining potential racemisation at the chiral centre. Results: Evaluation of the chiral stability of the two enantiomers to metabolism by rat S9 fractions, showed no racemisation of enantiomers. There were notable differences in the biodistribution between the racemate and the R- and S-enantiomers. All compounds had

  18. Evaluation of D-isomers of 4-borono-2-18F-fluoro-phenylalanine and O-11C-methyl-tyrosine as brain tumor imaging agents: a comparative PET study with their L-isomers in rat brain glioma.

    Science.gov (United States)

    Kanazawa, Masakatsu; Nishiyama, Shingo; Hashimoto, Fumio; Kakiuchi, Takeharu; Tsukada, Hideo

    2018-06-13

    The potential of the D-isomerization of 4-borono-2- 18 F-fluoro-phenylalanine ( 18 F-FBPA) to improve its target tumor to non-target normal brain tissue ratio (TBR) was evaluated in rat brain glioma and compared with those of L- and D- 11 C-methyl-tyrosine ( 11 C-CMT). The L- or D-isomer of 18 F-FBPA was injected into rats through the tail vein, and their whole body kinetics and distributions were assessed using the tissue dissection method up to 90 min after the injection. The kinetics of L- and D- 18 F-FBPA or L- and D- 11 C-CMT in the C-6 glioma-inoculated rat brain were measured for 90 or 60 min, respectively, using high-resolution animal PET, and their TBRs were assessed. Tissue dissection analyses showed that D- 18 F-FBPA uptake was significantly lower than that of L- 18 F-FBPA in the brain and abdominal organs, except for the kidney and bladder, reflecting the faster elimination rate of D- 18 F-FBPA than L- 18 F-FBPA from the blood to the urinary tract. PET imaging using 18 F-FBPA revealed that although the brain uptake of D- 18 F-FBPA was significantly lower than that of L- 18 F-FBPA, the TBR of the D-isomer improved to 6.93 from 1.45 for the L-isomer. Similar results were obtained with PET imaging using 11 C-CMT with a smaller improvement in TBR to 1.75 for D- 11 C-CMT from 1.33 for L- 11 C-CMT. The present results indicate that D- 18 F-FBPA is a better brain tumor imaging agent with higher TBR than its original L-isomer and previously reported tyrosine-based PET imaging agents. This improved TBR of D- 18 F-FBPA without any pre-treatments, such as tentative blood-brain barrier disruption using hyperosmotic agents or sonication, suggests that the D-isomerization of BPA results in the more selective accumulation of 10 B in tumor cells that is more effective and less toxic than conventional L-BPA.

  19. Imagined Transcultural Histories and Geographies

    Directory of Open Access Journals (Sweden)

    Bronwyn Winter

    2012-11-01

    Full Text Available In a globalised world, an assumption prevails that the nation has somehow lost its power to regulate our lives, being undermined by other forces, either top-down through the impact of global capitalism or bottom-up through migrations, transnational religious, ethnic or social movement communities or other transversal politics. A related idea is that ‘culture’ is now irrevocably hybridised and border-zoned, that we no longer live in a world of discrete, located, identifiable and historically grounded cultures but in some unstable and for-the-moment insterstitiality, a sort of cultural interlanguage that sits outside well-mapped structures of power. Yet, just as the nation and the boundaries it sets around culture are being conceptually chased from our maps of the world, they come galloping back to reassert themselves. They do so politically, economically, legally, symbolically. Amidst all the noise of our transnationalisms, hybridities and interstitialities, the idea of what it is to be ‘Australian’ or ‘French’ or ‘Filipino’ or ‘Asian’ reaffirms itself, in mental geographies and constructed histories, as our ‘imagined community’ (to use Benedict Anderson’s famous term [Anderson 1983], or indeed, ‘imagined Other’, even if it is an imagined ‘Other’ that we would somehow wish to incorporate into our newly hybridised Self. Using the notion of transcultural mappings, the articles in this special issue investigate this apparent paradox. They look at how the Self and Other have been mapped through imagined links between geography, history and cultural location. They interrogate the tension between the persistence of mappings of the world based on discrete national or cultural identities on one hand, and, on the other hand, the push to move beyond these carefully guarded borders and problematise precise notions of identity and belonging.

  20. Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [45Ti](salan)Ti(dipic)

    DEFF Research Database (Denmark)

    Severin, Gregory; Nielsen, Carsten H.; Jensen, Andreas Tue Ingemann

    2015-01-01

    We present a novel solid-phase based 45Ti radiolabeling methodology and the implementation of 45Ti-PET in titanium-based antineoplastics using the showcase compound [45Ti](salan)Ti(dipic). This development is intended to allow elucidation of the biodistribution and pharmacokinetics of promising new...

  1. Radiosynthesis and biological evaluation of 18F-labeled 4-anilinoquinazoline derivative (18F-FEA-Erlotinib) as a potential EGFR PET agent.

    Science.gov (United States)

    Huang, Shun; Han, Yanjiang; Chen, Min; Hu, Kongzhen; Qi, Yongshuai; Sun, Penghui; Wang, Men; Wu, Hubing; Li, Guiping; Wang, Quanshi; Du, Zhiyun; Zhang, Kun; Zhao, Suqing; Zheng, Xi

    2018-04-01

    Epidermal growth factor receptor (EGFR) has gained significant attention as a therapeutic target. Several EGFR targeting drugs (Gefitinib and Erlotinib) have been approved by US Food and Drug Administration (FDA) and have received high approval in clinical treatment. Nevertheless, the curative effect of these medicines varied in many solid tumors because of the different levels of expression and mutations of EGFR. Therefore, several PET radiotracers have been developed for the selective treatment of responsive patients who undergo PET/CT imaging for tyrosine kinase inhibitor (TKI) therapy. In this study, a novel fluorine-18 labeled 4-anilinoquinazoline based PET tracer, 1N-(3-(1-(2- 18 F-fluoroethyl)-1H-1,2,3-triazol-4-yl)phenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine ( 18 F-FEA-Erlotinib), was synthesized and biological evaluation was performed in vitro and in vivo. 18 F-FEA-Erlotinib was achieved within 50min with over 88% radiochemical yield (decay corrected RCY), an average specific activity over 50GBq/μmol, and over 99% radiochemical purity. In vitro stability study showed no decomposition of 18 F-FEA-Erlotinib after incubated in PBS and FBS for 2h. Cellular uptake and efflux experiment results indicated the specific binding of 18 F-FEA-Erlotinib to HCC827 cell line with EGFR exon 19 deletions. In vivo, Biodistribution studies revealed that 18 F-FEA-Erlotinib exhibited rapid blood clearance both through hepatobiliary and renal excretion. The tumor uptake of 18 F-FEA-Erlotinib in HepG2, HCC827, and A431 tumor xenografts, with different EGFR expression and mutations, was visualized in PET images. Our results demonstrate the feasibility of using 18 F-FEA-Erlotinib as a PET tracer for screening EGFR TKIs sensitive patients. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. PET/CT with intravenous contrast can be used for PET attenuation correction in cancer patients

    DEFF Research Database (Denmark)

    Berthelsen, A K; Holm, S; Loft, A

    2005-01-01

    PURPOSE: If the CT scan of a combined PET/CT study is performed as a full diagnostic quality CT scan including intravenous (IV) contrast agent, the quality of the joint PET/CT procedure is improved and a separate diagnostic CT scan can be avoided. CT with IV contrast can be used for PET attenuation...... correction, but this may result in a bias in the attenuation factors. The clinical significance of this bias has not been established. Our aim was to perform a prospective clinical study where each patient had CT performed with and without IV contrast agent to establish whether PET/CT with IV contrast can...... scans without, and then with contrast agent, followed by an 18F-fluorodeoxyglucose whole-body PET scan. The CT examinations were performed with identical parameters on a GE Discovery LS scanner. The PET data were reconstructed with attenuation correction based on the two CT data sets. A global...

  3. Eismitte in the Scientific Imagination

    DEFF Research Database (Denmark)

    Martin-Nielsen, Janet

    was a setting for scientific knowledge production as well as diplomatic maneuvering, providing new insights into the history of polar exploration and the intertwining of scientific and geopolitical considerations. Author Janet Martin-Nielsen draws on new research in private, government, military......Since the first attempts by Europeans to penetrate Greenland's interior, its geometric center, Eismitte (‘middle ice’), has been one of the most forbidding but scientifically rich locations in the Arctic. Tracing its history from European contact through the Cold War, this study shows how Eismitte......, and institutional archives in many languages in multiple countries to illuminate Eismitte’s place in the scientific imagination....

  4. Imagination as poetics of cognition

    Directory of Open Access Journals (Sweden)

    Grazia Pulvirenti

    2013-06-01

    Full Text Available Abstract Our work bases on the hypothesis of an existing interconnection between the symbolic and the metaphoric elements of the text responding to a series of mind patterns compressing perception and experience through the emerging process of conceptual blending triggering the semantic process during the creative act of poiesis. This enquiry focuses on the use of a peculiar rhetorical figure in an exemplar literary text of the famous German poet Goethe. We will try to point out the allegorical function of the scene dedicated to the «Mothers’ Kingdom», in his Faust II as a powerful poetical meta-reflection on imagination, cognition and poetics itself.

  5. "Holy Cow! This Stuff Is Real!" from Imagining Ministry to Pastoral Imagination

    Science.gov (United States)

    Campbell-Reed, Eileen R.; Scharen, Christian

    2011-01-01

    How do seminarians move from imagining ministry to embodying pastoral imagination? Stories gathered from seminarians in their final year of study show the complexity of shifting from classroom work, which foregrounds theory and intellectual imagination, to more embodied, relational, and emotionally intense engagements of ministry. Stories about…

  6. Present and future aspects of PET examinations

    International Nuclear Information System (INIS)

    Inoue, Tomio

    2003-01-01

    The PET examination gives the body distribution image of a compound labeled with the positron emitter manufactured by cyclotron. Recently, PET with F18-deoxyglucose (FDG) attracts considerable attention because the imaging is particularly useful for cancer detection. Since the technique was authorized by the United States (US) official health insurance in 1998, the number of the examination is increasing, which is also under similar situation in Japan due to the latest partial authorization for some malignant tumors. In Japan, about 30,000 examinations per year are carried out, half of which, in private hospitals. Their purpose is increasingly for cancer detection. For future PET examination, awaited are improvement of PET camera and development of a novel imaging agent. PET/CT imaging is for the former and F18-α-methyltyrosine, for the latter. Miniaturization of cyclotron, FDG delivery system, improved FDG synthetic method, popularization of PET/CT, development of PET camera for health examination, clinical trial of a novel imaging agent, and spread of PET health examination and operation of PET Center, are expected for future progress of PET technique. (N.I.)

  7. Imagining value, imagining users: academic technology transfer for health innovation.

    Science.gov (United States)

    Miller, Fiona Alice; Sanders, Carrie B; Lehoux, Pascale

    2009-04-01

    Governments have invested heavily in the clinical and economic promise of health innovation and express increasing concern with the efficacy and efficiency of the health innovation system. In considering strategies for 'better' health innovation, policy makers and researchers have taken a particular interest in the work of universities and related public research organizations: How do these organizations identify and transfer promising innovations to market, and do these efforts make best use of public sector investments? We conducted an ethnographic study of technology transfer offices (TTOs) in Ontario and British Columbia, Canada, to consider the place of health and health system imperatives in judgments of value in early-stage health innovation. Our analysis suggests that the valuation process is poorly specified as a set of task-specific judgments. Instead, we argue that technology transfer professionals are active participants in the construction of the innovation and assign value by 'imagining' the end product in its 'context of use'. Oriented as they are to the commercialization of health technology, TTOs understand users primarily as market players. The immediate users of TTOs' efforts are commercial partners (i.e., licensees, investors) who are capable of translating current discoveries into future commodities. The ultimate end users - patients, clinicians, health systems - are the future consumers of the products to be sold. Attention to these proximate and more distal users in the valuation process is a complex and constitutive feature of the work of health technology transfer. At the same time, judgements about individual technologies are made in relation to a broader imperative through which TTOs seek to imagine and construct sustainable innovation systems. Judgments of value are rendered sensible in relation to the logic of valuation for systems of innovation that, in turn, configure users of health innovation in systemic ways.

  8. Malassezia spp. dan Peranannya sebagai Penyebab Dermatitis pada Hewan Peliharaan (MALASSEZIA SPP AND ITS ROLE AS THE CAUSAL AGENT OF DERMATITIS IN PET ANIMALS

    Directory of Open Access Journals (Sweden)

    Pradipta Nuri Adiyati

    2015-05-01

    Full Text Available Malassezia is dimorphic yeast found normally in the animal healthy skin. Malassezia can causehealth problem in pet animals, such as dogs, cats, and other domestic animals. Varies according itsvirulence, Malassezia can cause skin changes characterized by severe pruritus, yellowish erythema andscab, greasy skin, bad odor with hyperpigmentation and lichenification in the face, paws, and neck bottom,as well as belly. Laboratory diagnosis can be performed either by microscopic examination of nativepreparations, or molecular biology. Treatment of Malassezia’s infection can still be made using someantifungals currently available. Malassezia pachydermatitis infection has been known as zoonoticpotential.

  9. Whole-body biodistribution and brain PET imaging with [{sup 18}F]AV-45, a novel amyloid imaging agent - a pilot study

    Energy Technology Data Exchange (ETDEWEB)

    Lin, K.-J. [Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taiwan (China); Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taiwan (China); Hsu, W.-C. [Department of Neurology, Chang Gung Memorial Hospital, Taiwan (China); Hsiao, I.-T.; Wey, S.-P. [Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taiwan (China); Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taiwan (China); Jin, L.-W. [M.I.N.D. Institute and Department of Pathology, University of California, Davis, CA (United States); Skovronsky, Daniel [Avid Radiopharmaceuticals, Inc., Philadelphia, PA (United States); Wai, Y.-Y. [Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taiwan (China); Department of Radiology, Chang Gung Memorial Hospital, Taiwan (China); Chang, H.-P.; Lo, C.-W.; Yao, C.H.; Yen, T.-C. [Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taiwan (China); Kung, M.-P. [Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taiwan (China); Department of Radiology, University of Pennsylvania, Philadelphia, PA (United States)

    2010-05-15

    Purpose: The compound (E)-4-(2-(6-(2-(2-(2-{sup 18}F-fluoroethoxy)ethoxy)ethoxy) pyridin-3-yl)vinyl)-N-methylbenzenamine ([{sup 18}F]AV-45) is a novel radiopharmaceutical capable of selectively binding to {beta}-amyloid (A{beta}) plaques. This pilot study reports the safety, biodistribution, and radiation dosimetry of [{sup 18}F]AV-45 in human subjects. Methods: In vitro autoradiography and fluorescent staining of postmortem brain tissue from patients with Alzheimer's disease (AD) and cognitively healthy subjects were performed to assess the specificity of the tracer. Biodistribution was assessed in three healthy elderly subjects (mean age: 60.0{+-}5.2 years) who underwent 3-h whole-body positron emission tomography (PET)/computed tomographic (CT) scans after a bolus injection of 381.9{+-}13.9 MBq of [{sup 18}F]AV-45. Another six subjects (three AD patients and three healthy controls, mean age: 67.7{+-}13.6 years) underwent brain PET studies. Source organs were delineated on PET/CT. All subjects underwent magnetic resonance imaging (MRI) for obtaining structural information. Results: In vitro autoradiography revealed exquisitely high specific binding of [{sup 18}F]AV-45 to postmortem AD brain sections, but not to the control sections. There were no serious adverse events throughout the study period. The peak uptake of the tracer in the brain was 5.12{+-}0.41% of the injected dose. The highest absorbed organ dose was to the gallbladder wall (184.7{+-}78.6 {mu}Gy/MBq, 4.8 h voiding interval). The effective dose equivalent and effective dose values for [{sup 18}F]AV-45 were 33.8{+-}3.4 {mu}Sv/MBq and 19.3{+-}1.3 {mu}Sv/MBq, respectively. Conclusion: [{sup 18}F]AV-45 binds specifically to A{beta} in vitro, and is a safe PET tracer for studying A{beta} distribution in human brain. The dosimetry is suitable for clinical and research application.

  10. Imagine Creating Rubrics that Develop Creativity

    Science.gov (United States)

    Young, Linda Payne

    2009-01-01

    English teachers are by nature rather imaginative, a trait that is not taught in a methods class or listed as a disposition in standards for teacher preparation. Whether as part of a learning activity or a "what if" question posed in a literature discussion, imagination and creativity are integral parts of classrooms and their inclusion is as…

  11. Discussion: Imagining the Languaged Worker's Language

    Science.gov (United States)

    Urciuoli, Bonnie

    2016-01-01

    What people perceive as "a language"--a named entity--is abstracted from practices and notions about those practices. People take for granted that language is somehow a "thing," an objectively distinct and bounded entity. How languages come to be thus imagined indexes the conditions under which they are imagined. The articles…

  12. Theological imagination as hermeneutical device: Exploring the ...

    African Journals Online (AJOL)

    In the past, biblical scholarship has neglected the hermeneutical contribution that an imaginal engagement with the text may make. The author's aim in this article was to develop theological imagination as a hermeneutical device. This was done by briefly considering the concurrence in the hermeneutic contributions of three ...

  13. [{sup 11}C]SMe-ADAM, an imaging agent for the brain serotonin transporter: synthesis, pharmacological characterization and microPET studies in rats

    Energy Technology Data Exchange (ETDEWEB)

    Zessin, Joerg [Institut fuer Bioanorganische und Radiopharmazeutische Chemie, Forschungszentrum Rossendorf, 01314 Dresden (Germany)]. E-mail: j.zessin@fz-rossendorf.de; Deuther-Conrad, Winnie [Institut fuer Interdisziplinaere Isotopenforschung, 04318 Leipzig (Germany); Kretzschmar, Marion [Institut fuer Bioanorganische und Radiopharmazeutische Chemie, Forschungszentrum Rossendorf, 01314 Dresden (Germany); Wuest, Frank [Institut fuer Bioanorganische und Radiopharmazeutische Chemie, Forschungszentrum Rossendorf, 01314 Dresden (Germany); Pawelke, Beate [Institut fuer Bioanorganische und Radiopharmazeutische Chemie, Forschungszentrum Rossendorf, 01314 Dresden (Germany); Brust, Peter [Institut fuer Interdisziplinaere Isotopenforschung, 04318 Leipzig (Germany); Steinbach, Joerg [Institut fuer Interdisziplinaere Isotopenforschung, 04318 Leipzig (Germany); Bergmann, Ralf [Institut fuer Bioanorganische und Radiopharmazeutische Chemie, Forschungszentrum Rossendorf, 01314 Dresden (Germany)

    2006-01-15

    N,N-Dimethyl-2-(2-amino-4-methylthiophenylthio)benzylamine (S Me-Adam, 1) is a highly potent and selective inhibitor of the serotonin transporter (SPERT). This compound was labeled with carbon-11 by methylation of the S-desmethyl precursor 10 with [{sup 11}C]methyl iodide to obtain the potential positron emission tomography (PET) radioligand [{sup 11}C]S Me-Adam. The radiochemical yield was 27{+-}5%, and the specific radioactivity was 26-40 GBq/{mu}mol at the end of synthesis. Ex vivo and in vivo biodistribution experiments in rats demonstrated a rapid accumulation of the radiotracer in brain regions known to be rich in SPERT, such as the thalamus/hypothalamus region (3.59{+-}0.41%ID/g at 5 min after injection). The specific uptake reached a thalamus to cerebellum ratio of 6.74{+-}0.95 at 60 min postinjection. The [{sup 11}C]SMe-ADAM uptake in the thalamus was significantly decreased by pretreatment with fluoxetine to 38{+-}11% of the control value. Furthermore, no metabolites of [{sup 11}C]SMe-ADAM could be detected in the SERT-rich regions of the rat brain. It is concluded that [{sup 11}C]SMe-ADAM may be a suitable PET ligand for SERT imaging in the living brain.

  14. [11C]SMe-ADAM, an imaging agent for the brain serotonin transporter: synthesis, pharmacological characterization and microPET studies in rats

    International Nuclear Information System (INIS)

    Zessin, Joerg; Deuther-Conrad, Winnie; Kretzschmar, Marion; Wuest, Frank; Pawelke, Beate; Brust, Peter; Steinbach, Joerg; Bergmann, Ralf

    2006-01-01

    N,N-Dimethyl-2-(2-amino-4-methylthiophenylthio)benzylamine (S Me-Adam, 1) is a highly potent and selective inhibitor of the serotonin transporter (SPERT). This compound was labeled with carbon-11 by methylation of the S-desmethyl precursor 10 with [ 11 C]methyl iodide to obtain the potential positron emission tomography (PET) radioligand [ 11 C]S Me-Adam. The radiochemical yield was 27±5%, and the specific radioactivity was 26-40 GBq/μmol at the end of synthesis. Ex vivo and in vivo biodistribution experiments in rats demonstrated a rapid accumulation of the radiotracer in brain regions known to be rich in SPERT, such as the thalamus/hypothalamus region (3.59±0.41%ID/g at 5 min after injection). The specific uptake reached a thalamus to cerebellum ratio of 6.74±0.95 at 60 min postinjection. The [ 11 C]SMe-ADAM uptake in the thalamus was significantly decreased by pretreatment with fluoxetine to 38±11% of the control value. Furthermore, no metabolites of [ 11 C]SMe-ADAM could be detected in the SERT-rich regions of the rat brain. It is concluded that [ 11 C]SMe-ADAM may be a suitable PET ligand for SERT imaging in the living brain

  15. Effect of the prosthetic group on the pharmacologic properties of 18F-labeled rhodamine B, a potential myocardial perfusion agent for positron emission tomography (PET).

    Science.gov (United States)

    Bartholomä, Mark D; Gottumukkala, Vijay; Zhang, Shaohui; Baker, Amanda; Dunning, Patricia; Fahey, Frederic H; Treves, S Ted; Packard, Alan B

    2012-12-27

    We recently reported the development of the 2-[(18)F]fluoroethyl ester of rhodamine B as a potential positron emission tomography (PET) tracer for myocardial perfusion imaging. This compound, which was prepared using a [(18)F]fluoroethyl prosthetic group, has significant uptake in the myocardium in rats but also demonstrates relatively high liver uptake and is rapidly hydrolyzed in vivo in mice. We have now prepared (18)F-labeled rhodamine B using three additional prosthetic groups (propyl, diethylene glycol, and triethylene glycol) and found that the prosthetic group has a significant effect on the in vitro and in vivo properties of these compounds. Of the esters prepared to date, the diethylene glycol ester is superior in terms of in vitro stability and pharmacokinetics. These observations suggest that the prosthetic group plays a significant role in determining the pharmacological properties of (18)F-labeled compounds. They also support the value of continued investigation of (18)F-labeled rhodamines as PET radiopharmaceuticals for myocardial perfusion imaging.

  16. The Effect of the Prosthetic Group on the Pharmacologic Properties of 18F-labeled Rhodamine B, a Potential Myocardial Perfusion Agent for PET

    Science.gov (United States)

    Bartholomä, Mark D.; Gottumukkala, Vijay; Zhang, Shaohui; Baker, Amanda; Dunning, Patricia; Fahey, Frederic H.; Treves, S. Ted; Packard, Alan B.

    2013-01-01

    We recently reported the development of the 2-[18F]fluoroethyl ester of rhodamine B as a potential positron emission tomography (PET) tracer for myocardial perfusion imaging. This compound, which was prepared using a [18F]fluoroethyl prosthetic group, has significant uptake in the myocardium in rats, but also demonstrates relatively high liver uptake and is rapidly hydrolyzed in vivo in mice. We have now prepared 18F-labeled rhodamine B using three additional prosthetic groups (propyl, diethylene glycol, and triethylene glycol) and found that the prosthetic group has a significant effect on the in vitro and in vivo properties of these compounds. Of the esters prepared to date, the diethylene glycol ester is superior in terms of in vitro stability and pharmacokinetics. These observations suggest that the prosthetic group plays a significant role in determining the pharmacological properties of 18F-labeled compounds. They also support the value of continued investigation of 18F-labeled rhodamines as PET radiopharmaceuticals for myocardial perfusion imaging. PMID:23210516

  17. [11C]SMe-ADAM, an imaging agent for the brain serotonin transporter: synthesis, pharmacological characterization and microPET studies in rats.

    Science.gov (United States)

    Zessin, Jörg; Deuther-Conrad, Winnie; Kretzschmar, Marion; Wüst, Frank; Pawelke, Beate; Brust, Peter; Steinbach, Jörg; Bergmann, Ralf

    2006-01-01

    N,N-Dimethyl-2-(2-amino-4-methylthiophenylthio)benzylamine (SMe-ADAM, 1) is a highly potent and selective inhibitor of the serotonin transporter (SERT). This compound was labeled with carbon-11 by methylation of the S-desmethyl precursor 10 with [(11)C]methyl iodide to obtain the potential positron emission tomography (PET) radioligand [(11)C]SMe-ADAM. The radiochemical yield was 27 +/- 5%, and the specific radioactivity was 26-40 GBq/micromol at the end of synthesis. Ex vivo and in vivo biodistribution experiments in rats demonstrated a rapid accumulation of the radiotracer in brain regions known to be rich in SERT, such as the thalamus/hypothalamus region (3.59 +/- 0.41%ID/g at 5 min after injection). The specific uptake reached a thalamus to cerebellum ratio of 6.74 +/- 0.95 at 60 min postinjection. The [(11)C]SMe-ADAM uptake in the thalamus was significantly decreased by pretreatment with fluoxetine to 38 +/- 11% of the control value. Furthermore, no metabolites of [(11)C]SMe-ADAM could be detected in the SERT-rich regions of the rat brain. It is concluded that [(11)C]SMe-ADAM may be a suitable PET ligand for SERT imaging in the living brain.

  18. Supporting imagination in the context of work

    DEFF Research Database (Denmark)

    Kolbæk, Ditte

    2018-01-01

    This chapter explores imagination in the context of work. When we work, we meet challenges and problems that we are obliged to solve. Most often we utilize well-defined work processes for the problem-solving, but now and then we run into new problems that need something else. This “something else...... hierarchical levels in the organisation. The research question is: How may a workplace support imagination for problem solving?...... on the task as well as colleagues who are influenced by the problem and its solution. Imagination becomes crucial to problem solving, and the final solution is a new way of doing – it is an innovation. When imagination is required at work, the workplace represents the context of the imagination. This chapter...

  19. Giambattista Vico and the psychological imagination

    DEFF Research Database (Denmark)

    Tateo, Luca

    2015-01-01

    psychology, despite the fact that imaginative processes are involved in even the most mundane activities. In this editorial, I first present the rationale and the content of the articles and commentaries. Then I outline a brief history of the concept of imagination before Vico, drawing some consequences...... for contemporary psychology. Finally, I provide the proposal for a new research program on imagination as a higher psychological function that enables us to manipulate complex meanings of both linguistic and iconic forms in the process of experiencing.......This special issue originates from an international workshop on “Vico and imagination,” that took place at Aalborg University in 2014, within a research project on Giambattista Vico and the epistemology of psychology. Imagination has inexplicably been relegated to the background in contemporary...

  20. Re-imagining Active Learning

    DEFF Research Database (Denmark)

    Dall'Alba, Gloria; Bengtsen, Søren Smedegaard

    2018-01-01

    is largely lacking in the literature on active learning. In this article, we explore the possibility of re-imagining, or at least extending, the meaning of active learning by drawing out dimensions that are neither readily visible nor instrumental, as much of this literature implies. Drawing from educational......Ample attention is being paid in the higher education literature to promoting active learning among students. Where studies on active learning report student outcomes, they indicate improved or equivalent outcomes when compared with traditional lectures, which are considered more passive...... philosophy and, in particular, existential philosophies, we argue that active learning may also be partly invisible, unfocused, unsettling, and not at all instrumentalsometimes even leaving the learner more confused and (temporarily) incompetent. However, such forms of undisclosed or ‘dark’ learning, we...

  1. EIT and the Popular Imagination

    Science.gov (United States)

    Gurman, J. B.

    2005-01-01

    The Extreme ultraviolet Imaging Telescope on board SOHO, designed and built by Principal Investigator Jean-Pierre Delaboudiniere and his French/Belgan/US team, has produced numerous scientific breakthroughs, and has become both the standard coronal finder telescope and the determinant of whether halo coronal mass ejections are earthward-directed. Due to the dramatic nature of the images produced by EIT over the last nearly ten years, those images have been adopted worldwide in a manner no one could have foreseen before the launch of SOHO. I examine a small sample of the many scientific, commercial, and cultural uses of EIT imagery from the last decade in order to demonstrate how well-visualized, scientific imagery can first penetrate and then become an accepted part of the popular imagination.

  2. Pet Health

    Science.gov (United States)

    ... companionship and a feeling of safety to your life. Before getting a pet, think carefully about which ... Gaining or losing a lot of weight quickly Strange behavior Being sluggish and tired Trouble getting up ...

  3. Pet Allergy Quiz

    Science.gov (United States)

    ... Treatments ▸ Allergies ▸ Pet Allergy ▸ Pet Allergy Quiz Share | Pet Allergy Quiz More than half of U.S. households ... cat family. Yet, millions of people suffer from pet allergies. Take this quiz to test your knowledge ...

  4. Positron Emission Tomography (PET)

    International Nuclear Information System (INIS)

    Welch, M.J.

    1990-01-01

    Positron emission tomography (PET) assesses biochemical processes in the living subject, producing images of function rather than form. Using PET, physicians are able to obtain not the anatomical information provided by other medical imaging techniques, but pictures of physiological activity. In metaphoric terms, traditional imaging methods supply a map of the body's roadways, its, anatomy; PET shows the traffic along those paths, its biochemistry. This document discusses the principles of PET, the radiopharmaceuticals in PET, PET research, clinical applications of PET, the cost of PET, training of individuals for PET, the role of the United States Department of Energy in PET, and the futures of PET. 22 figs

  5. Positron Emission Tomography (PET)

    Energy Technology Data Exchange (ETDEWEB)

    Welch, M.J.

    1990-01-01

    Positron emission tomography (PET) assesses biochemical processes in the living subject, producing images of function rather than form. Using PET, physicians are able to obtain not the anatomical information provided by other medical imaging techniques, but pictures of physiological activity. In metaphoric terms, traditional imaging methods supply a map of the body's roadways, its, anatomy; PET shows the traffic along those paths, its biochemistry. This document discusses the principles of PET, the radiopharmaceuticals in PET, PET research, clinical applications of PET, the cost of PET, training of individuals for PET, the role of the United States Department of Energy in PET, and the futures of PET. 22 figs.

  6. Positron Emission Tomography (PET)

    Science.gov (United States)

    Welch, M. J.

    1990-01-01

    Positron emission tomography (PET) assesses biochemical processes in the living subject, producing images of function rather than form. Using PET, physicians are able to obtain not the anatomical information provided by other medical imaging techniques, but pictures of physiological activity. In metaphoric terms, traditional imaging methods supply a map of the body's roadways, its, anatomy; PET shows the traffic along those paths, its biochemistry. This document discusses the principles of PET, the radiopharmaceuticals in PET, PET research, clinical applications of PET, the cost of PET, training of individuals for PET, the role of the United States Department of Energy in PET, and the futures of PET.

  7. Imagining wrong: Fictitious contexts mitigate condemnation of harm more than impurity.

    Science.gov (United States)

    Sabo, John S; Giner-Sorolla, Roger

    2017-01-01

    Over 5 experiments, we test the fictive pass asymmetry hypothesis. Following observations of ethics and public reactions to media, we propose that fictional contexts, such as reality, imagination, and virtual environments, will mitigate people's moral condemnation of harm violations, more so than purity violations. That is, imagining a purely harmful act is given a "fictive pass," in moral judgment, whereas imagining an abnormal act involving the body is evaluated more negatively because it is seen as more diagnostic of bad character. For Experiment 1, an undergraduate sample (N = 250) evaluated 9 vignettes depicting an agent committing either violations of harm or purity in real life, watching them in films, or imagining them. For Experiments 2 and 3, online participants (N = 375 and N = 321, respectively) evaluated a single vignette depicting an agent committing a violation of harm or purity that either occurred in real life, was imagined, watched in a film, or performed in a video game. Experiment 4 (N = 348) used an analysis of moderated mediation to demonstrate that the perceived wrongness of fictional purity violations is explained both by the extent to which they are seen as a cue to, and a cause of, a poor moral character. Lastly, Experiment 5 (N = 484) validated our manipulations and included the presumption of desire as an additional mediator of the fictive pass asymmetry effects. We discuss implications for moral theories of act and character, anger and disgust, and for media use and regulation. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  8. Direct Comparison of Radiolabeled Probes FMAU, FHBG, and FHPG as PET Imaging Agents for HSV1-tk Expression in a Human Breast Cancer Model

    Directory of Open Access Journals (Sweden)

    Mian M. Alauddin

    2004-04-01

    Full Text Available 2′-Deoxy-2′-fluoro-5-methyl-1-β-d-arabinofuranosyluracil (FMAU, 9-(4-fluoro-3-hydroxy-methyl-butylguanine (FHBG and 9-[(3-fluoro-1-hydroxy-2-propoxymethyl]-guanine (FHPG have been evaluated in a human breast cancer model as potential radiotracers for PET imaging of HSV1-tk gene expression. In vitro accumulation of [14C]FMAU, [18F]FHBG, and [18F]FHPG in HSV1-tk-expressing cells was 14- to 16-fold (p < .001, 9- to 13-fold (p < .001, and 2- to 3-fold (p < .05 higher than tk-negative control cells, respectively, between 30 and 240 min. Accumulation of FMAU and FHBG in vector-transduced cells was 10- to 14-fold and 6- to 10-fold higher than wild-type cells, respectively. At 2 hr, uptake of [14C]FMAU in tk-positive cells was 6.3-fold and 60-fold higher than [18F]FHBG and [18F]FHPG, respectively. In vivo, tumor uptake of [14C]FMAU in HSV1-tk-expressing cells was 3.7-fold and 5.5-fold (p < .001 higher than tk-negative control cells at 1 and 2 hr, respectively. Tumor uptake of [18F]FHBG was 4.2-fold and 12.6-fold higher (p < .001 than tk-negative cells at the same time points. Incorporation of [14C]FMAU in tk-positive tumor was 18-fold and 24-fold higher (p < .001 than [18F]FHBG at 1 and 2 hr, respectively. Micro-PET images support the biodistribution results and indicate that both [18F]FMAU and [18F]FHBG are useful for imaging HSV1-tk expression in breast cancer. Although FMAU demonstrates higher total incorporation (%dose/g in tumor tissue compared with the other tracers, FHBG is superior in terms of specific accumulation in transfected cells at later time points.

  9. Imagining Other Lives | Mackenzie | Philosophical Papers

    African Journals Online (AJOL)

    collaborative' models of democratic deliberation procedures need to be supplemented by 'internal-reflective' deliberation. The exercise of the moral imagination plays a central role in Goodin's account of 'democratic deliberation within'.

  10. Integrating Project Portfolio With Business Strategy: Imagineering

    Directory of Open Access Journals (Sweden)

    Cesar Buaes Dal Maso

    2015-12-01

    Full Text Available Aligning project management to the strategy of a big company is a difficult job. Through Imagineering (the business department and project management program, The Walt Disney Company has done this alignment in an exemplary way. Using a theoretical investigation, this study analyzed the Imagineering as a reference in strategic management of global projects through Disney´s business portfolio, a global benchmarking and with Malmberg et al. (2010 as a company guide. As the main results of the correlations carried out, it was noted that the Imagineers who work in project teams apply tools and techniques with a strategic vision focused on differentiation, generating value, and mixing imagination with technical capacity. The Blue Sky department and its integrated units make possible the creation and deployment of the attractions, the theme parks, hotels, resorts and the Disney sea cruises, demonstrating in this way, to be a highly effective project management office.

  11. Imagine stopping the progression of Alzheimer's

    Science.gov (United States)

    ... Issue Past Issues Imagine stopping the progression of Alzheimer's Past Issues / Fall 2006 Table of Contents For ... I have friends and loved ones suffering from Alzheimer's. But I can imagine… and hope for… a ...

  12. New control system: IMAGIN supervision in ADA

    International Nuclear Information System (INIS)

    Maugeais, C.

    1991-01-01

    The structure, the initialization, the operating cycle, the different messages and the errors treatment of the new user oriented packages written in ADA language for IMAGIN software are presented. (A.B.). 2 figs

  13. Synthesis of [{sup 18}F]-labelled nebivolol as a β{sub 1}-adrenergic receptor antagonist for PET imaging agent

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Taek Soo; Park, Jeong Hoon; Lee, Jun Young; Yang, Seung Dae [Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute (KAERI), Jeongeup (Korea, Republic of); Chang, Dong Jo [College of pharmacy, Sunchon National University, Suncheon (Korea, Republic of)

    2017-02-15

    Selective β{sub 1}-agonist and antagonists are used for the treatment of cardiac diseases including congestive heart failure, angina pectoris and arrhythmia. Selective β{sub 1}-antagonists including nebivolol have high binding affinity on β{sub 1}-adrenergic receptor, not β{sub 2}-receptor mainly expressed in smooth muscle. Nebivolol is one of most selective β{sub 1}-blockers in clinically used β{sub 1}- blockers including atenolol and bisoprolol. We tried to develop clinically useful cardiac PET tracers using a selective β{sub 1}-blocker. Nebivolol is C{sub 2}-symmetric and has two chromane moiety with a secondary amino alcohol and aromatic fluorine. We adopted the general synthetic strategy using epoxide ring opening reaction. Unlike formal synthesis of nebivolol, we prepared two chromane building blocks with fluorine and iodine which was transformed to diaryliodonium salt for labelling of {sup 18}F. Two epoxide building blocks were readily prepared from commercially available chromene carboxylic acids (1, 8). Then, the amino alcohol building block (15) was prepared by ammonolysis of epoxide (14) followed by coupling reaction with the other building block, epoxide (7). Diaryliodonium salt, a precursor for {sup 18}F-aromatic substitution, was synthesized in moderate yield which was readily subjected to {sup 18}F-aromatic substitution to give {sup 18}F-labelled nebivolol.

  14. The Imagined Audience on Social Network Sites

    Directory of Open Access Journals (Sweden)

    Eden Litt

    2016-02-01

    Full Text Available When people construct and share posts on social network sites like Facebook and Twitter, whom do they imagine as their audience? How do users describe this imagined audience? Do they have a sub-audience in mind (e.g., “friends who like reality television”? Do they share more broadly and abstractly (e.g., “the public”? Do such imaginings fluctuate each time a person posts? Using a mixed-methods approach involving a 2-month-long diary study of 119 diverse American adults and their 1,200 social network site posts, supplemented with follow-up interviews (N = 30, this study explores the imagined audience on social network sites. The findings reveal that even though users often interacted with large diverse audiences as they posted, they coped by envisioning either very broad abstract imagined audiences or more targeted specific imagined audiences composed of personal ties, professional ties, communal ties, and/or phantasmal ties. When people had target imagined audiences in mind, they were most often homogeneous and composed of people’s friends and family. Users’ imaginings typically fluctuated among these audience types as they posted even though the potential audience as per their posts’ privacy settings often did not change. The findings provide a list of audience types, as well as detailed descriptions, examples, and frequencies on which future research can build. With people’s online presence playing an important role for their reputations, these findings provide more insight into for whom people are managing their privacy and whom they have in mind as they share.

  15. Validation of two fluoro-analogues of N,N-dimethyl-2-(2'-amino-4'-hydroxymethyl-phenylthio)benzylamine as serotonin transporter imaging agents using microPET

    Energy Technology Data Exchange (ETDEWEB)

    Jarkas, Nachwa; Voll, Ronald J.; Williams, Larry [Department of Radiology, Emory CSI, WWHC, Atlanta, GA 30329 (United States); Goodman, Mark M., E-mail: mgoodma@emory.ed [Department of Radiology, Emory CSI, WWHC, Atlanta, GA 30329 (United States)

    2010-07-15

    Introduction: Carbon-11 (C-11) N,N-dimethyl-2-(2'-amino-4'-hydroxymethyl-phenylthio)benzylamine ([{sup 11}C]HOMADAM) has been reported as highly specific and selective positron emission tomography (PET) radiotracer showing fast kinetics for the human brain serotonin transporter (SERT). In our continued effort to develop appropriate PET SERT radioligand that can be labeled with either C-11 or fluorine-18 (F-18), two new C-11 labeled analogues of HOMADAM, [{sup 11}C]-N,N-dimethyl-2-(2'-amino-5'-fluoro-4'-hydroxymethyl-phenylthio) benzylamine ([{sup 11}C]-(2)) and [{sup 11}C]-N,N-dimethyl-2-(2'-amino-4-fluoro-4'-hydroxymethyl-phenylthio) benzylamine ([{sup 11}C]-(3)) have been synthesized and evaluated along the previously reported [{sup 11}C]-N,N-dimethyl-2-(2'-amino-5-fluoro-4'-hydroxymethyl-phenylthio) benzylamine ([{sup 11}C]-(1)). Methods: The in vitro competitive binding assays were performed in cells transfected with human SERT (hSERT), human dopamine transporter (hDAT), and human norepinephrine transporter (hNET). [{sup 11}C]-(2) and [{sup 11}C]-(3) were prepared by methylation of their monomethylbenzylamine precursors 13 and 22 with cyclotron produced [{sup 11}C]iodomethane ([{sup 11}C]CH{sub 3}I), respectively. Uptake and kinetics of [{sup 11}C]-(2) and [{sup 11}C]-(3) in the brain regions of interest were determined in anesthetized rhesus monkeys using Concorde microPET P4. Results: 2 and 3 displayed moderate and high affinity for the SERT with Kis (SERT) = 5.45 and 1.10 nM (vs [{sup 3}H]citalopram), respectively. After High Performance Liquid Chromatography (HPLC) purification, [{sup 11}C]-(2) and [{sup 11}C]-(3) were obtained in 23 and 9% radiochemical yield (RCY) and log Ps{sub 7.4} of 1.77 and 1.91, respectively. The microPET images of [{sup 11}C]-(2) and [{sup 11}C]-(3) showed clear localization in the monkey brain regions rich in SERT with midbrain to cerebellum ratios of 1.75 and 3.86 at 85 min post

  16. 64Cu-Labeled Trastuzumab Fab-PEG24-EGF Radioimmunoconjugates Bispecific for HER2 and EGFR: Pharmacokinetics, Biodistribution, and Tumor Imaging by PET in Comparison to Monospecific Agents.

    Science.gov (United States)

    Kwon, Luke Yongkyu; Scollard, Deborah A; Reilly, Raymond M

    2017-02-06

    Heterodimerization of EGFR with HER2 coexpressed in breast cancer (BC) promotes tumor growth, and increased EGFR expression is associated with trastuzumab resistance. Our aim was to construct 64 Cu-labeled bispecific radioimmunoconjugates (bsRIC) composed of trastuzumab Fab, which binds HER2 linked through a polyethylene glycol (PEG 24 ) spacer to EGF, and to compare their pharmacokinetic, biodistribution, and tumor imaging characteristics by positron-emission tomography (PET). bsRICs were generated by linking maleimide modified trastuzumab Fab with thiolated EGF through a thioether bond. HER2 and EGFR binding were assessed in vitro in MDA-MB-231 (EGFR mod /HER2 low ), MDA-MB-468 (EGFR high /HER2 neg ), MDA-MB-231-H2N (EGFR mod /HER2 mod ), and SKOV3 (EGFR low /HER2 high ) cells by competition and saturation cell binding assays to estimate the dissociation constant (K d ). The elimination of the 64 Cu-NOTA-trastuzumab Fab-PEG 24 -EGF bsRICs from the blood of Balb/c mice was compared to monospecific 64 Cu-NOTA-trastuzumab Fab and 64 Cu-NOTA-EGF. MicroPET/CT imaging was performed in NOD/SCID mice bearing subcutaneous MDA-MB-468, MDA-MB-231/H2N, or SKOV3 human BC xenografts at 24 and 48 h postinjection (p.i.) of bsRICs. Tumor and normal tissue uptake were quantified by biodistribution studies and compared to monospecific agents. The binding of bsRICs to MDA-MB-231 cells was decreased to 24.5 ± 5.2% by excess EGF, while the binding of bsRICs to SKOV3 cells was decreased to 38.6 ± 5.4% by excess trastuzumab Fab, demonstrating specific binding to both EGFR and HER2. 64 Cu-labeled bsRICs incorporating the PEG 24 spacer were eliminated more slowly from the blood than 64 Cu-bsRICs without the PEG spacer and were cleared much more slowly than 64 Cu-NOTA-Fab or 64 Cu-NOTA-EGF. All three tumor xenografts were visualized by microPET/CT at 24 and 48 h p.i. of bsRICs. Biodistribution studies at 48 h p.i. in NOD/SCID mice with MDA-MB-231/H2N tumors demonstrated significantly

  17. Imagine a world without cancer

    International Nuclear Information System (INIS)

    Brücher, Björn LDM; Polkowski, Wojciech; Wallner, Grzegorz; Verwaal, Vic; Garofalo, Alfredo; D’Ugo, Domenico; Roviello, Franco; Steinau, Hans-Ulrich; Wallace, Timothy J; Daumer, Martin; Maihle, Nitah; Lyman, Gary; Reid, Thomas J III; Ducreux, Michel; Kitagawa, Yuko; Knuth, Alexander; Zilberstein, Bruno; Steele, Scott R; Jamall, Ijaz S; Hillegersberg, Richard van; Pollock, Raphael E; Lordick, Florian; Yang, Han-Kwang; Ushijima, Toshikazu; Yeoh, Khay-Guan; Skricka, Tomas

    2014-01-01

    to result in an optimized anticancer strategy. Herein, we introduce such an anticancer strategy for all cancer patients, experts, and organizations: Imagine a World without Cancer

  18. Imaginative science education the central role of imagination in science education

    CERN Document Server

    Hadzigeorgiou, Yannis

    2016-01-01

    This book is about imaginative approaches to teaching and learning school science. Its central premise is that science learning should reflect the nature of science, and therefore be approached as an imaginative/creative activity. As such, the book can be seen as an original contribution of ideas relating to imagination and creativity in science education. The approaches discussed in the book are storytelling, the experience of wonder, the development of ‘romantic understanding’, and creative science, including science through visual art, poetry and dramatization. However, given the perennial problem of how to engage students (of all ages) in science, the notion of ‘aesthetic experience’, and hence the possibility for students to have more holistic and fulfilling learning experiences through the aforementioned imaginative approaches, is also discussed. Each chapter provides an in-depth discussion of the theoretical background of a specific imaginative approach (e.g., storytelling, ‘wonder-full’ s...

  19. Imagine math 3 between culture and mathematics

    CERN Document Server

    2015-01-01

    Imagine mathematics, imagine with the help of mathematics, imagine new worlds, new geometries, new forms. This volume in the series “Imagine Math” casts light on what is new and interesting in the relationships between mathematics, imagination, and culture. The book opens by examining the connections between modern and contemporary art and mathematics, including Linda D. Henderson’s contribution. Several further papers are devoted to mathematical models and their influence on modern and contemporary art, including the work of Henry Moore and Hiroshi Sugimoto. Among the many other interesting contributions are an homage to Benoît Mandelbrot with reference to the exhibition held in New York in 2013 and the thoughts of Jean-Pierre Bourguignon on the art and math exhibition at the Fondation Cartier in Paris. An interesting part is dedicated to the connections between math, computer science and theatre with the papers by C. Bardainne and A. Mondot.  The topics are treated in a way that is rigorous but capt...

  20. Respiratory gating in cardiac PET

    DEFF Research Database (Denmark)

    Lassen, Martin Lyngby; Rasmussen, Thomas; Christensen, Thomas E

    2017-01-01

    BACKGROUND: Respiratory motion due to breathing during cardiac positron emission tomography (PET) results in spatial blurring and erroneous tracer quantification. Respiratory gating might represent a solution by dividing the PET coincidence dataset into smaller respiratory phase subsets. The aim...... of our study was to compare the resulting imaging quality by the use of a time-based respiratory gating system in two groups administered either adenosine or dipyridamole as the pharmacological stress agent. METHODS AND RESULTS: Forty-eight patients were randomized to adenosine or dipyridamole cardiac...... stress (82)RB-PET. Respiratory rates and depths were measured by a respiratory gating system in addition to registering actual respiratory rates. Patients undergoing adenosine stress showed a decrease in measured respiratory rate from initial to later scan phase measurements [12.4 (±5.7) vs 5.6 (±4...

  1. Synthesis and Biodistribution of Lipophilic Monocationic Gallium Radiopharmaceuticals Derived from N,N′-bis(3-aminopropyl)-N,N′-dimethylethylenediamine: Potential Agents for PET Myocardial Imaging with 68Ga

    Science.gov (United States)

    Hsiao, Yui-May; Mathias, Carla J.; Wey, Shiaw-Pyng; Fanwick, Phillip E.; Green, Mark A.

    2009-01-01

    Introduction In locations that lack nearby cyclotron facilities for radionuclide production, generator-based 68Ga-radiopharmaceuticals might have clinical utility for positron emission tomography (PET) studies of myocardial perfusion and other physiologic processes. Methods The lipophilic, monocationic 67Ga-labeled gallium chelates of five novel hexadentate bis(salicylaldimine) ligands, the bis(salicylaldimine), bis(3-methoxysalicylaldimine), bis(4-methoxysalicylaldimine), bis(6-methoxysalicylaldimine), and bis(4,6-dimethoxysalicylaldimine) of N,N′-bis(3-aminopropyl)-N,N′-dimethylethylenediamine (BAPDMEN), were prepared. The structure of the unlabeled [Ga(4-MeOsal)2BAPDMEN]+PF6− salt was determined by X-ray crystallography, and the biodistribution of each of the 67Ga-labeled gallium chelates determined in rats following i.v. administration and compared to the biodistribution of [86Rb]rubidium chloride. Results The [Ga(4-MeOsal)2BAPDMEN]+PF6− complex exhibits the expected pseudo-octahedral N4O22− coordination sphere about the Ga3+ center with a trans-disposition of the phenolate oxygen atoms. All five of the 67Ga-radiopharmaceuticals were found to afford the desired myocardial retention of the radiogallium. The [67/68Ga][Ga(3-MeOsal)2BAPDMEN]1+ radiopharmaceutical appears to have the best properties for myocardial imaging, exhibiting 2% of the injected dose in the heart at both 1-minute and 2-hours post-injection and very high heart/non-target ratios (heart/blood ratios of 7.6 ± 1.0 and 54 ± 10 at 1-min and 120-min, respectively; heart/liver ratios of 1.8 ± 0.4 and 39 ± 3 at 1-min and 120-min, respectively). Conclusions Most of these new agents, particularly [67/68Ga][Ga(3-MeOsal)2BAPDMEN]1+, would appear superior to previously reported bis(salicyaldimines) of N,N′-bis(3-aminopropyl)ethylenediamine as candidates for PET imaging of the heart with 68Ga. PMID:19181267

  2. Synthesis and biodistribution of lipophilic and monocationic gallium radiopharmaceuticals derived from N,N'-bis(3-aminopropyl)-N,N'-dimethylethylenediamine: potential agents for PET myocardial imaging with 68Ga

    International Nuclear Information System (INIS)

    Hsiao, Y.-M.; Mathias, Carla J.; Wey, S.-P.; Fanwick, Phillip E.; Green, Mark A.

    2009-01-01

    Introduction: In locations that lack nearby cyclotron facilities for radionuclide production, generator-based 68 Ga radiopharmaceuticals might have clinical utility for positron emission tomography (PET) studies of myocardial perfusion and other physiological processes. Methods: The lipophilic and monocationic 67 Ga-labeled gallium chelates of five novel hexadentate bis(salicylaldimine) ligands the bis(salicylaldimine), bis(3-methoxysalicylaldimine), bis(4-methoxysalicylaldimine), bis(6-meth,oxysalicylaldimine), and bis(4,6-dimethoxysalicylaldimine) of N,N'-bis(3-aminopropyl)-N,N'-dimethylethylenediamine (BAPDMEN), were prepared. The structure of the unlabeled [Ga(4-MeOsal) 2 BAPDMEN] + PF 6 - salt was determined by X-ray crystallography, and the biodistribution of each of the 67 Ga-labeled gallium chelates was determined in rats following intravenous administration and compared with the biodistribution of [ 86 Rb]rubidium chloride. Results: The [Ga(4-MeOsal) 2 BAPDMEN] + PF 6 - complex exhibited the expected pseudo-octahedral N 4 O 2 2- coordination sphere about the Ga 3+ center with a trans disposition of the phenolate oxygen atoms. All five 67 Ga radiopharmaceuticals were found to afford the desired myocardial retention of the radiogallium. The [ 67/68 Ga][Ga(3-MeOsal) 2 BAPDMEN] 1+ radiopharmaceutical appears to have the best properties for myocardial imaging, exhibiting 2% of the injected dose in the heart 1 min and 2 h postinjection and very high heart/nontarget ratios (heart/blood ratios of 7.6±1.0 and 54±10 at 1 and 120 min, respectively; heart/liver ratios of 1.8±0.4 and 39±3 at 1 and 120 min, respectively). Conclusions: Most of these new agents, particularly [ 67/68 Ga][Ga(3-MeOsal) 2 BAPDMEN] 1+ , would appear superior to previously reported bis(salicylaldimine) ligands of N,N'-bis(3-aminopropyl)ethylenediamine as candidates for PET imaging of the heart with 68 Ga

  3. Radiochemical synthesis of 3-(4-[18F] Fluorophenyl)-8-hydroxy-1, 2, 3, 4-tetrahydrochromeno [3, 4-c] pyridin-5-one: A putative dopamine D$4 receptor PET imaging agent

    International Nuclear Information System (INIS)

    Li, G.C.; Yin, D.Z.; Wang, M.W.; Cheng, D.F.; Wang, Y.X.

    2005-01-01

    Introduction: The dopamine D 4 receptor has lately received increasing interest since it has been hypothesized to be involved in the pathology and pharmacotherapy of schizophrenia. While this receptor is expressed in lower density in various extrastriatal brain regions and its distribution is still unclear due to the lack of suitable imaging agent and its level change in schizophrenia is controversial. Herein, based on the structure-activity analysis of chromeno[3, 4-c]pyridine- 5-ones as potential dopamine D 4 receptor ligands, a putative D 4 subtype positron emission tomography (PET) radioligand, 3-(4-[ 18 F]fluorophenyl)-8-hydroxy-1, 2, 3, 4-tetrahydrochromeno [3, 4-c]pyridin-5-one ([ 18 F]FHTP), was designed and synthesized. Methods: The radiochemical synthesis route was shown in Figure 1. [ 18 F]Fluoride was produced with a Cyclone-30 (IBA, Belgium) by 18 O(p, n) 18 F reaction using enriched 18 O-H 2 O and eluted from a Dowex 1-X8 anion-exchange column with aqueous potassium carbonate (20 mg/mL). 4-[ 18 F]Fluorobenzaldehyde was prepared according to the method reported by Alan A. Wilson and et al.. Then, 8-hydroxy-1, 2, 3, 4-tetrahydrochromeno [3, 4-c]pyridin-5-one, sodium cyanoborohydride, methanol and acetic acid were added to the dry residue, The mixture was then sealed and heated at 120 degree C for 12 min. At the end of the reaction, the mixture was cooled, diluted with ethyl acetate and washed with water. The extracted organic layer was passed through a small anhydrous magnesium sulfate column. After removal of the solvents in the mixture at 50 degree C under a stream of nitrogen, the obtained residue was redissolved in methanol and purified with a semi-preparative HPLC system, then the desired product was collected. Results: The radiochemical synthesis of [ 18 F]FHTP took around 110 min at EOS with an overall radiochemical yield 19% (decay-corrected) and its radiochemical purity was higher than 95%. Conclusion: A presumed dopamine D 4 receptor PET

  4. Healthy Pets and People

    Science.gov (United States)

    ... prevent the spread of germs between pets and people. Keep pets and their supplies out of the kitchen, and ... a local wildlife rehabilitation facility. More Information Healthy Pets Healthy People Clean Hands Save Lives! Stay Healthy at Animal ...

  5. Imaging cell competition in Drosophila imaginal discs.

    Science.gov (United States)

    Ohsawa, Shizue; Sugimura, Kaoru; Takino, Kyoko; Igaki, Tatsushi

    2012-01-01

    Cell competition is a process in which cells with higher fitness ("winners") survive and proliferate at the expense of less fit neighbors ("losers"). It has been suggested that cell competition is involved in a variety of biological processes such as organ size control, tissue homeostasis, cancer progression, and the maintenance of stem cell population. By advent of a genetic mosaic technique, which enables to generate fluorescently marked somatic clones in Drosophila imaginal discs, recent studies have presented some aspects of molecular mechanisms underlying cell competition. Now, with a live-imaging technique using ex vivo-cultured imaginal discs, we can dissect the spatiotemporal nature of competitive cell behaviors within multicellular communities. Here, we describe procedures and tips for live imaging of cell competition in Drosophila imaginal discs. Copyright © 2012 Elsevier Inc. All rights reserved.

  6. The Aesthetics of Imagination in Design

    DEFF Research Database (Denmark)

    Folkmann, Mads Nygaard

    In The Aesthetics of Imagination in Design, Mads Folkmann investigates design in both material and immaterial terms. Design objects, Folkmann argues, will always be dual phenomena--material, and immaterial, sensual and conceptual, actual and possible. Drawing on formal theories of aesthetics...... and the life of design objects; aesthetics describes the sensual, conceptual, and contextual codes through which design objects communicate; the concept of the possible--the enabling of new uses, conceptions, and perceptions--lies behind imagination and aesthetics. The possible, Folkmann argues, is contained...

  7. IMAGINE: Interstellar MAGnetic field INference Engine

    Science.gov (United States)

    Steininger, Theo

    2018-03-01

    IMAGINE (Interstellar MAGnetic field INference Engine) performs inference on generic parametric models of the Galaxy. The modular open source framework uses highly optimized tools and technology such as the MultiNest sampler (ascl:1109.006) and the information field theory framework NIFTy (ascl:1302.013) to create an instance of the Milky Way based on a set of parameters for physical observables, using Bayesian statistics to judge the mismatch between measured data and model prediction. The flexibility of the IMAGINE framework allows for simple refitting for newly available data sets and makes state-of-the-art Bayesian methods easily accessible particularly for random components of the Galactic magnetic field.

  8. Rhetorical facets of imagination in contemporary poetry

    Directory of Open Access Journals (Sweden)

    Hassan Delbari

    2015-03-01

    Full Text Available Abstract The present article deals with the trend of literary imaginative descriptions in the purview of poetical imaginations which have been regarded greatly in the discourse of rhetoric’s. The different facets of imagination of these imageries are also introduced in this article. Throughout this study poetical demonstrations are dealt with on the basis of their indications, functions and profundity. Meanwhile overcoming superficial and intermediate layers of imagination towards inner and profound thoughts would represent the domination of the poets in depiction of imagery. For this purpose, an introduction of numerous imagery layers with their deep and superficial, positive and subsidiary nature is presented through some examples. The result suggests that the extent of imagery complexity among many poets has a direct relation to their subjectivity in such a way that different levels of imageries are internalized as a unique stylistic feature of any individual poet. He endeavors to ornament his poem through imagery devices. Yousefi says: “any poem in which there is not imagery cannot be regarded as a poem. “The attractiveness of such imagination and the success or failure of the poet in conveying this imagery is a matter of poet’s tendency in using imagery devices. Through this article the contemporary poems are analyzed from the view point of objectivity and subjectivity. Furthermore, the poems are studied on their functions. The analysis has been carried out from two perspectives idiosyncratic features of the poet and the characteristics of the era in which he has lived. The examples presented in this article are selected from among the poets with different linguistic backgrounds and unique ideologies. The reason behind this specific consideration is an indication of a generalizability rather than a representativeness of few poets with their idiosyncratic styles. Therefore, the results indicate the style characteristics

  9. PET studies of potential chemotherapeutic agents: Pt. 10; Synthesis of ''no-carrier-added'' ( sup 11 C)-HECNU: the hydroxyethyl analog of the chemotherapeutic agent BCNU

    Energy Technology Data Exchange (ETDEWEB)

    Conway, T.; Diksic, M. (Montreal Neurological Inst. and Hospital, PQ (Canada). McConnell Brain Imaging Centre McGill Univ., Montreal, PQ (Canada). Dept. of Neurology and Neurosurgery)

    1991-01-01

    Carbon-11-labeled HECNU (1-(2-chloroethyl)-1-nitroso-3-(2-hydroxyethyl) urea) a potential chemotherapeutic agent, has been prepared by the nitrosation of the corresponding carbon-11-labeled urea, HECU, (1-(2-chloroethyl)-3-(2-hydroxyethyl) urea). The isomeric byproduct of nitrosation, 1-(2-chloroethyl)-3-nitroso-3-(2-hydroxyethyl) urea can be efficiently removed by preparative scale HPLC on a Partisil column. ({sup 11}C)-HECU was prepared by reacting ethanolamine with ({sup 11}C)-2-chloroethyl-isocyanate which was itself prepared by reacting ({sup 11}C)-phosgene with 2-chloroethylamine hydrochloride suspended in dioxane at 60-65{sup o}C. This synthesis yielded ({sup 11}C)-HECNU with an average radiochemical purity of 98% in an average radiochemical yield of 18% relative to the radioactivity measured at the end of the {sup 11}C-phosgene introduction. (author).

  10. The application of PET-CT in gastrointestinal stromal tumor

    International Nuclear Information System (INIS)

    Xian Weijun; Feng Yanlin

    2009-01-01

    Gastrointestinal stromal tumor (GIST) is a mesenchymal neoplasm of uncertain malignant potential that arises predominantly in the gastrointestinal tract. Due to lack of specific physical signs, imagin g-x examination is an important auxiliary means in diagnosing gastrointestinal stromal tumor. Compared to other conventional imaging examinations, PET-CT has demonstrated unique superiority in staging, response evaluation and follow-up of gastrointestinal stromal tumor. And now it presents an overview of the application valuation of PET-CT and related imaging technology in gastrointestinal stromal tumor as follow. (authors)

  11. PET/CT with intravenous contrast can be used for PET attenuation correction in cancer patients

    International Nuclear Information System (INIS)

    Berthelsen, A.K.; Holm, S.; Loft, A.; Klausen, T.L.; Andersen, F.; Hoejgaard, L.

    2005-01-01

    If the CT scan of a combined PET/CT study is performed as a full diagnostic quality CT scan including intravenous (IV) contrast agent, the quality of the joint PET/CT procedure is improved and a separate diagnostic CT scan can be avoided. CT with IV contrast can be used for PET attenuation correction, but this may result in a bias in the attenuation factors. The clinical significance of this bias has not been established. Our aim was to perform a prospective clinical study where each patient had CT performed with and without IV contrast agent to establish whether PET/CT with IV contrast can be used for PET attenuation without reducing the clinical value of the PET scan. A uniform phantom study was used to document that the PET acquisition itself is not significantly influenced by the presence of IV contrast medium. Then, 19 patients referred to PET/CT with IV contrast underwent CT scans without, and then with contrast agent, followed by an 18 F-fluorodeoxyglucose whole-body PET scan. The CT examinations were performed with identical parameters on a GE Discovery LS scanner. The PET data were reconstructed with attenuation correction based on the two CT data sets. A global comparison of standard uptake value (SUV) was performed, and SUVs in tumour, in non-tumour tissue and in the subclavian vein were calculated. Clinical evaluation of the number and location of lesions on all PET/CT scans was performed twice, blinded and in a different random order, by two independent nuclear medicine specialists. In all patients, the measured global SUV of PET images based on CT with IV contrast agent was higher than the global activity using non-contrast correction. The overall increase in the mean SUV (for two different conversion tables tested) was 4.5±2.3% and 1.6±0.5%, respectively. In 11/19 patients, focal uptake was identified corresponding to malignant tumours. Eight out of 11 tumours showed an increased SUV max (2.9±3.1%) on the PET images reconstructed using IV contrast

  12. Dual PET and Near-Infrared Fluorescence Imaging Probes as Tools for Imaging in Oncology

    Science.gov (United States)

    An, Fei-Fei; Chan, Mark; Kommidi, Harikrishna; Ting, Richard

    2016-01-01

    OBJECTIVE The purpose of this article is to summarize advances in PET fluorescence resolution, agent design, and preclinical imaging that make a growing case for clinical PET fluorescence imaging. CONCLUSION Existing SPECT, PET, fluorescence, and MRI contrast imaging techniques are already deeply integrated into the management of cancer, from initial diagnosis to the observation and management of metastases. Combined positron-emitting fluorescent contrast agents can convey new or substantial benefits that improve on these proven clinical contrast agents. PMID:27223168

  13. Rhetorical facets of imagination in contemporary poetry

    Directory of Open Access Journals (Sweden)

    Hassan Delbari

    2015-04-01

    Full Text Available Abstract The present article deals with the trend of literary imaginative descriptions in the purview of poetical imaginations which have been regarded greatly in the discourse of rhetoric’s. The different facets of imagination of these imageries are also introduced in this article. Throughout this study poetical demonstrations are dealt with on the basis of their indications, functions and profundity. Meanwhile overcoming superficial and intermediate layers of imagination towards inner and profound thoughts would represent the domination of the poets in depiction of imagery. For this purpose, an introduction of numerous imagery layers with their deep and superficial, positive and subsidiary nature is presented through some examples. The result suggests that the extent of imagery complexity among many poets has a direct relation to their subjectivity in such a way that different levels of imageries are internalized as a unique stylistic feature of any individual poet. He endeavors to ornament his poem through imagery devices. Yousefi says: “any poem in which there is not imagery cannot be regarded as a poem. “The attractiveness of such imagination and the success or failure of the poet in conveying this imagery is a matter of poet’s tendency in using imagery devices. Through this article the contemporary poems are analyzed from the view point of objectivity and subjectivity. Furthermore, the poems are studied on their functions. The analysis has been carried out from two perspectives idiosyncratic features of the poet and the characteristics of the era in which he has lived. The examples presented in this article are selected from among the poets with different linguistic backgrounds and unique ideologies. The reason behind this specific consideration is an indication of a generalizability rather than a representativeness of few poets with their idiosyncratic styles. Therefore, the results indicate the style characteristics of poet

  14. Forward Ever Backward Never, Global Imaginations

    NARCIS (Netherlands)

    Stultiens, Andrea

    Ebifananyi 4, based on the Ham Mukasa Foundation Archive that HIPUganda digitised, has had several exhibition versions. This one is part of Global Imaginations, an exhibition organised by Museum de Lakenhal in Leiden in an old factory. In this installation the visitor had the opportunity to dive

  15. Driving Symbolic Consumption through Imagined Vertical Movements

    DEFF Research Database (Denmark)

    Ostinelli, Massimiliano; Ringberg, Torsten; Luna, David

    Drawing on theories of embodied cognition and compensatory consumption, we provide evidence that merely imagining oneself moving upward or downward affects preference for symbolic products. Altogether, two studies show that magining taking an elevator down, as opposed to up, decreases self...

  16. Just Imagine...Improving the Band Experience.

    Science.gov (United States)

    Zerull, David S.

    1992-01-01

    Discusses the use of imagination as a tool to improve students' musicianship. Suggests that imagery can be used to teach intonation, tone color, sight-reading, and expression. Describes active listening in which the students must use musical memory and participate in musical expression to produce a certain sound that may be difficult to describe.…

  17. The Sociological Imagination and Social Responsibility

    Science.gov (United States)

    Hironimus-Wendt, Robert J.; Wallace, Lora Ebert

    2009-01-01

    In this paper, we maintain that sociologists should deliberately teach social responsibility as a means of fulfilling the promise that C. Wright Mills envisioned. A key aspect of the sociological imagination includes a sense of social responsibility, but that aspect is best learned through a combination of experience and academic knowledge.…

  18. Second-Language Learning through Imaginative Theory

    Science.gov (United States)

    Broom, Catherine

    2011-01-01

    This article explores how Egan's (1997) work on imagination can enrich our understanding of teaching English as a second language (ESL). Much has been written on ESL teaching techniques; however, some of this work has been expounded in a standard educational framework, which is what Egan calls an assembly-line model. This model can easily underlie…

  19. Practicing Sociological Imagination through Writing Sociological Autobiography

    Science.gov (United States)

    Kebede, Alem

    2009-01-01

    Sociological imagination is a quality of mind that cannot be adopted by simply teaching students its discursive assumptions. Rather, it is a disposition, in competition with other forms of sensibility, which can be acquired only when it is practiced. Adhering to this important pedagogical assumption, students were assigned to write their…

  20. Higgs into the heart of imagination

    CERN Document Server

    Van den Bergh, Hannie

    2010-01-01

    Higgs is the documentary about the quest for the Higgs particle, also known as "The God Particle". It is considered the missing link in particle physics. Higgs is a film about the curiosity, the passion, and the imaginative power of silence.

  1. Pet Problems at Home: Pet Problems in the Community.

    Science.gov (United States)

    Soltow, Willow

    1984-01-01

    Discusses problems of pets in the community, examining the community's role related to disruptive pets and pet overpopulation. Also discusses pet problems at home, offering advice on selecting a pet, meeting a pet's needs, and disciplining pets. Includes a list of books, films/filmstrips, teaching materials, and various instructional strategies.…

  2. Introduction: Victorian Fiction and the Material Imagination

    Directory of Open Access Journals (Sweden)

    Victoria Mills

    2008-04-01

    Full Text Available How should we deal with the ‘stuff' in books? This is the question addressed in the lead articles of the Spring 2008 issue of 19, all of which focus on some aspect of the material in relation to Victorian fiction. Gas, rocks, jewellery, automata and the entire contents of houses are examined in essays that explore the material imagination of Dickens, Hardy, George Eliot and Thackeray, among others. Moving forward from the previous edition, which different types of collected object, here contributors examine how the material is brought into collision with literature. The phrase 'material imagination' can be traced to the work of Gaston Bachelard who identifies two types of imagination, the formal and the material. Whereas the former focuses on surfaces and the visual perception of images, the latter consists of '…this amazing need for penetration which, going beyond the attractions of the imagination of forms, thinks matter, dreams in it, lives in it, or, in other words, materializes the imaginary'. As Bachelard suggests, the material imagination involves more than just a focus on the representation of objects and the contributions to this edition explore such wide ranging subjects as the gender politics of ownership, dispossession, the body as object, the politics of collecting and display and the dichotomy between the material and immaterial. In addition, this edition features a forum on digitisation and materiality. We are particularly pleased to be able to make use of 19's digital publishing format to further debates about digital media. In the forum, five contributors respond to a series of questions about the nature of the virtual object. All five have worked or are working on nineteenth-century digitisation projects so they are uniquely placed to consider issues surrounding representation and the nature of digital space.

  3. Principles or imagination? Two approaches to global justice.

    NARCIS (Netherlands)

    Coeckelbergh, Mark

    2007-01-01

    What does it mean to introduce the notion of imagination in the discussion about global justice? What is gained by studying the role of imagination in thinking about global justice? Does a focus on imagination imply that we must replace existing influential principle-centred approaches such as that

  4. 'Imagining ourselves': South African music as a vehicle for ...

    African Journals Online (AJOL)

    This paper examines some of the ways in which South African music is involved in the negotiation of white South African identity. In particular, it examines how music may be considered a vehicle for constructing 'imagined communities' and imagined individual others, and how these processes of imagining may serve to ...

  5. Imagining the Good Organization: Educational Restructuring in a Coastal Community.

    Science.gov (United States)

    Harris, Carol E.

    2002-01-01

    Describes town of Burnt Island, Newfoundland, including its need for imaginative survival; explores the nature of imaginative thought, including benefits to the individual and to society; describes threats to imaginative teaching within town's restructured school; describes characteristics common to the work of Greenfield, Greene, and Habermas…

  6. The Need for Imagination and Creativity in Instructional Design

    Science.gov (United States)

    Gibson, Pat

    2013-01-01

    The purpose of this article is to explore the need for imagination and creativity in adult education instructional design both online and face-to-face. It defines both imagination and creativity as well as provides an overview of the history of instructional design. It provides an examination of imagination and its application in educational…

  7. Theological imagination as hermeneutical device: Exploring the hermeneutical contribution of an imaginal engagement with the text

    Directory of Open Access Journals (Sweden)

    Anneke Viljoen

    2016-07-01

    Full Text Available In the past, biblical scholarship has neglected the hermeneutical contribution that an imaginal engagement with the text may make. The author’s aim in this article was to develop theological imagination as a hermeneutical device. This was done by briefly considering the concurrence in the hermeneutic contributions of three interpreters of biblical texts, with specific regard to their understanding of biblical imagination. These were Walter Brueggemann, Paul Ricoeur and Ignatius of Loyola. Their hermeneutical contributions concur in their understanding of a biblically informed imagination, and it is specifically this aspect of the concurrence of their thought that was explored. An illustration from Proverbs 14:27, which draws on the metaphor and biblical motif of the fountain or source of life, was put forward to demonstrate how the concurrence in the contributions of these biblical interpreters may influence an imaginal engagement with the text. Keywords: Old Testament; Proverbs; Hermeneutics; The fear of the Lord/Yahweh;  Walter Brueggemann; Paul Ricoeur;  Ignatius of Loyola; Imaginal engagement

  8. Brain PET scan

    Science.gov (United States)

    ... results on a PET scan. Blood sugar or insulin levels may affect the test results in people with diabetes . PET scans may be done along with a CT scan. This combination scan is called a PET/CT. Alternative Names Brain positron emission tomography; PET scan - brain References Chernecky ...

  9. Oncologic PET/CT: current status and controversies

    International Nuclear Information System (INIS)

    Siegel, B.A.; Dehdashti, F.

    2005-01-01

    The introduction of integrated PET/CT has dramatically increased the worldwide rate of growth for PET, predominantly for oncologic imaging with the glucose analog 18 F-fluorodeoxyglucose (FDG). A rapidly expanding body of literature demonstrates that the use FDG-PET/CT and the resultant ability to interpret coregistered and fused PET and CT images lead to improved observer confidence and improved diagnostic performance by comparison with PET alone, CT alone, and visually correlated PET and CT. The value of PET/CT is likely to be even greater with new PET radiopharmaceuticals under development, many of which produce PET images with even fewer anatomical landmarks than FDG images. PET/CT is also likely to lead to the resurrection of 18 F-fluoride as a principal agent for radionuclide bone imaging. There are a number of controversies related to PET/CT, including minimum training and experience requirements for interpreting physicians and defining new models for technical and professional reimbursement. (orig.)

  10. Musical expertise and the ability to imagine loudness.

    Directory of Open Access Journals (Sweden)

    Laura Bishop

    Full Text Available Most perceived parameters of sound (e.g. pitch, duration, timbre can also be imagined in the absence of sound. These parameters are imagined more veridically by expert musicians than non-experts. Evidence for whether loudness is imagined, however, is conflicting. In music, the question of whether loudness is imagined is particularly relevant due to its role as a principal parameter of performance expression. This study addressed the hypothesis that the veridicality of imagined loudness improves with increasing musical expertise. Experts, novices and non-musicians imagined short passages of well-known classical music under two counterbalanced conditions: 1 while adjusting a slider to indicate imagined loudness of the music and 2 while tapping out the rhythm to indicate imagined timing. Subtests assessed music listening abilities and working memory span to determine whether these factors, also hypothesised to improve with increasing musical expertise, could account for imagery task performance. Similarity between each participant's imagined and listening loudness profiles and reference recording intensity profiles was assessed using time series analysis and dynamic time warping. The results suggest a widespread ability to imagine the loudness of familiar music. The veridicality of imagined loudness tended to be greatest for the expert musicians, supporting the predicted relationship between musical expertise and musical imagery ability.

  11. Musical expertise and the ability to imagine loudness.

    Science.gov (United States)

    Bishop, Laura; Bailes, Freya; Dean, Roger T

    2013-01-01

    Most perceived parameters of sound (e.g. pitch, duration, timbre) can also be imagined in the absence of sound. These parameters are imagined more veridically by expert musicians than non-experts. Evidence for whether loudness is imagined, however, is conflicting. In music, the question of whether loudness is imagined is particularly relevant due to its role as a principal parameter of performance expression. This study addressed the hypothesis that the veridicality of imagined loudness improves with increasing musical expertise. Experts, novices and non-musicians imagined short passages of well-known classical music under two counterbalanced conditions: 1) while adjusting a slider to indicate imagined loudness of the music and 2) while tapping out the rhythm to indicate imagined timing. Subtests assessed music listening abilities and working memory span to determine whether these factors, also hypothesised to improve with increasing musical expertise, could account for imagery task performance. Similarity between each participant's imagined and listening loudness profiles and reference recording intensity profiles was assessed using time series analysis and dynamic time warping. The results suggest a widespread ability to imagine the loudness of familiar music. The veridicality of imagined loudness tended to be greatest for the expert musicians, supporting the predicted relationship between musical expertise and musical imagery ability.

  12. Counterfactual Imagination as a Mental Tool for Innovation

    Directory of Open Access Journals (Sweden)

    Monika Chylińska

    2017-11-01

    Full Text Available In the article I demonstrate some of the possible ways by which counterfactual im⁠agination can lead people to innovation and the creation of novel and valuable solutions. I start with adopting the broad definition of counterfactuals, by which counterfactual imagination is understood as the ability to imagine alternative states of affairs which can relate to the past, present or future. I explain how counterfactual imagination differs from other sorts of imaginative and creative thoughts, pointing out that counterfactual types of thinking always rely on facts and involve a change in some features of the actual world, leaving other such features unaltered. I also show that the concept of counterfactual imagination can be useful when we aim to describe the very earliest manifestations of imaginative capacities in children, which can be seen in their make-believe games. All the mentioned characteristics of counterfactual imagination are further used to examine how what if and would be sorts of thinking and imagining might influence people’s creative performance. I conclude with the suggestion that—if guided properly—counterfactual imagination could be a truly valuable mental tool for innovation. This demonstration is partly influenced by Ruth Byrne’s multi-faceted analysis of counterfactual imagination, mainly from her book, The Rational Imagination: How People Create Alternatives to Reality.

  13. The Aesthetics of Imagination in Design

    DEFF Research Database (Denmark)

    Folkmann, Mads Nygaard

    and the life of design objects; aesthetics describes the sensual, conceptual, and contextual codes through which design objects communicate; the concept of the possible--the enabling of new uses, conceptions, and perceptions--lies behind imagination and aesthetics. The possible, Folkmann argues, is contained...... methodology to cultural studies. Throughout, he offers concrete examples to illustrate theoretical points. Folkmann’s philosophically informed account shows design--in all its manifestations, from physical products to principles of organization--to be an essential medium for the articulation......In The Aesthetics of Imagination in Design, Mads Folkmann investigates design in both material and immaterial terms. Design objects, Folkmann argues, will always be dual phenomena--material, and immaterial, sensual and conceptual, actual and possible. Drawing on formal theories of aesthetics...

  14. Imaginative methodologies in the social sciences

    DEFF Research Database (Denmark)

    Imaginative Methodologies develops, expands and challenges conventional social scientific methodology and language by way of literary, poetic and other alternative sources of inspiration. Sociologists, social workers, anthropologists, criminologists and psychologists all try to rethink, provoke...... and reignite social scientific methodology. Imaginative Methodologies challenges the mainstream social science methodological orthodoxy closely guarding the boundaries between the social sciences and the arts and humanities, pointing out that authors and artists are often engaged in projects parallel to those...... of the social sciences and vice versa, and that artistic and cultural productions today do not constitute a specialist field, but are integral to our social reality. The book will be of interest to scholars and students in the social sciences and across the arts and humanities working with questions...

  15. PET reconstruction

    International Nuclear Information System (INIS)

    O'Sullivan, F.; Pawitan, Y.; Harrison, R.L.; Lewellen, T.K.

    1990-01-01

    In statistical terms, filtered backprojection can be viewed as smoothed Least Squares (LS). In this paper, the authors report on improvement in LS resolution by: incorporating locally adaptive smoothers, imposing positivity and using statistical methods for optimal selection of the resolution parameter. The resulting algorithm has high computational efficiency relative to more elaborate Maximum Likelihood (ML) type techniques (i.e. EM with sieves). Practical aspects of the procedure are discussed in the context of PET and illustrations with computer simulated and real tomograph data are presented. The relative recovery coefficients for a 9mm sphere in a computer simulated hot-spot phantom range from .3 to .6 when the number of counts ranges from 10,000 to 640,000 respectively. The authors will also present results illustrating the relative efficacy of ML and LS reconstruction techniques

  16. WHEN DEATH INTERCEPTS LIFE IN IMAGINATIVE WRITING

    OpenAIRE

    washington, gene

    2014-01-01

    The representation of death in imaginative writing is a "virtual" (as opposed to) an actual death. It always occurs in the context of a "virtual" (represented) life. In this text the author examines some of the ways death "intercepts" life in such writing. The subject is a vast, perhaps inexhaustible, one. The richest source, one the author dos not mine, is Shakespeare's interceptions of life by death.

  17. Imaging and PET - PET/CT imaging

    International Nuclear Information System (INIS)

    Von Schulthess, G.K.; Hany, Th.F.

    2008-01-01

    PET/CT has grown because the lack of anatomic landmarks in PET makes 'hardware-fusion' to anatomic cross-sectional data extremely useful. Addition of CT to PET improves specificity, but also sensitivity, and adding PET to CT adds sensitivity and specificity in tumor imaging. The synergistic advantage of adding CT is that the attenuation correction needed for PET data can also be derived from the CT data. This makes PET-CT 25-30% faster than PET alone, leading to higher patient throughput and a more comfortable examination for patients typically lasting 20 minutes or less. FDG-PET-CT appears to provide relevant information in the staging and therapy monitoring of many tumors, such as lung carcinoma, colorectal cancer, lymphoma, gynaecological cancers, melanoma and many others, with the notable exception of prostatic cancer. for this cancer, choline derivatives may possibly become useful radiopharmaceuticals. The published literature on the applications of FDG-PET-CT in oncology is still limited but several designed studies have demonstrated the benefits of PET-CT. (authors)

  18. Postmodern imaginative constructivism for STSE understanding

    Science.gov (United States)

    Robertson, Christian

    The influences of science and technology on society and the environment (STSE) have been an integral component of the formal educational curricula for four decades, and yet industrialized countries frequently struggle to balance the benefits of science and technology with the social justice and environmental issues inherent to contemporary society. Canadian citizens often fail to connect scientific and technological understandings with the subtle and yet ubiquitous personal, political, cultural, environmental, and social consequences that result from these understandings. This phenomenological research will explore potential discourses of control within education and society that may preclude authentic, contextual, and meaningful understandings of science and technology relative to their significant consequences, and an imaginative adaptation of Egan's Ironic Understanding and McGinn's Foreground and Background Dimensions to imaginatively express an awareness of postmodern STSE understandings. This research is designed to explore student understandings of how the diverse and complex influences of science and technology affect students through postmodern, imaginative, and constructivist photography. Participants demonstrated a limited Ironic Understanding of STSE, a critical awareness of specific modernist influences, increased personal and affective connections to science and technology, and an awareness of the duality of STSE. Participants' photographic artifacts can be utilized to inform teaching and learning strategies in order to purposefully craft curriculum and lesson plan design for personalized and engaging learning opportunities that incorporate students' awareness of STSE.

  19. [The role of imagination in modern medicine].

    Science.gov (United States)

    Schott, Heinz

    2004-06-01

    In Renaissance and early modern times, the concept of imagination (Latin imaginatio) was essential for the (natural) philosophical explanation of magic processes, especially in the anthropology of Paracelsus. He assumed that imagination was a natural vital power including cosmic, mental, phychical, and physical dimensions. The Paracelsians criticized traditional humor pathology ignoring their theory of' 'natural magic'. On the other hand, they were criticized by their adversaries as charlatans practicing 'black magic'. About 1800, in between enlightenment and romanticism, the healing concept of, animal magnetism' (Mesmerism) evoked an analogous debate, whether, magnetic' phenomena originated from a real (physical) power (so-called, fluidum') or were just due to fantasy or imagination (German Einbildungskraft). At the end of the 19th century, the French internist Hippolyte Bernheim created-against the background of medical hypnosis (hypnotism') as a consequence of Mesmerism - his theory of suggestion and autosuggestion: a new paradigm of psychological respectively psychosomatic medicine, which became the basis for the concept of, placebo' in modern biomedicine. From now on, all the effects of, alternative medicine' could easily be explained by the, placebo-effect', more or less founded - at least unconsciously - on fraud.

  20. Trends in PET imaging

    International Nuclear Information System (INIS)

    Moses, William W.

    2000-01-01

    Positron Emission Tomography (PET) imaging is a well established method for obtaining information on the status of certain organs within the human body or in animals. This paper presents an overview of recent trends PET instrumentation. Significant effort is being expended to develop new PET detector modules, especially those capable of measuring depth of interaction. This is aided by recent advances in scintillator and pixellated photodetector technology. The other significant area of effort is development of special purpose PET cameras (such as for imaging breast cancer or small animals) or cameras that have the ability to image in more than one modality (such as PET / SPECT or PET / X-Ray CT)

  1. Imaging Alzheimer's disease pathophysiology with PET

    Directory of Open Access Journals (Sweden)

    Lucas Porcello Schilling

    Full Text Available ABSTRACT Alzheimer's disease (AD has been reconceptualised as a dynamic pathophysiological process characterized by preclinical, mild cognitive impairment (MCI, and dementia stages. Positron emission tomography (PET associated with various molecular imaging agents reveals numerous aspects of dementia pathophysiology, such as brain amyloidosis, tau accumulation, neuroreceptor changes, metabolism abnormalities and neuroinflammation in dementia patients. In the context of a growing shift toward presymptomatic early diagnosis and disease-modifying interventions, PET molecular imaging agents provide an unprecedented means of quantifying the AD pathophysiological process, monitoring disease progression, ascertaining whether therapies engage their respective brain molecular targets, as well as quantifying pharmacological responses. In the present study, we highlight the most important contributions of PET in describing brain molecular abnormalities in AD.

  2. IMAGINING THE ABSENT PARTNER - INTIMACY AND IMAGINATION IN LONG-DISTANCE RELATIONSHIPS

    Directory of Open Access Journals (Sweden)

    Iveta Jurkane-Hobein

    2015-01-01

    Full Text Available The dominant discourse on relationships in modernity argues for the importance of intimacy, including the intimacy of bodies, for the relationship to be continuous. This raises the question as to how couples that cannot meet face-to-face on a regular basis due to geographical distance maintain intimacy during repetitious non-co-presence. In this article, intimacy is seen as a relational quality that is created and maintained by individuals themselves through practices of intimacy (Jamieson, 2011. The study aims to analyse practices of intimacy in long-distance relationships (LDRs that enable long-distance couples to make their relationship continuous beyond face-to-face encounters. The study is based on 19 in-depth interviews with indi Shrani viduals in Latvia with LDR experience, and argues that the intimacy practices in LDRs trigger imagination. Imagination, in its turn, enables practicing four dimensions of intimacy: embodied, emotional, daily and imagined.

  3. PET / MRI vs. PET / CT. Indications Oncology

    International Nuclear Information System (INIS)

    Oliva González, Juan P.

    2016-01-01

    Hybrid techniques in Nuclear Medicine is currently a field in full development for diagnosis and treatment of various medical conditions. With the recent advent of PET / MRI much it speculated about whether or not it is superior to PET / CT especially in oncology. The Conference seeks to clarify this situation by dealing issues such as: State of the art technology PET / MRI; Indications Oncology; Some clinical cases. It concludes by explaining the oncological indications of both the real and current situation of the PET / MRI. (author)

  4. Pets and Parasites

    Science.gov (United States)

    ... good news is that this rarely happens. Most pet-to-people diseases can be avoided by following a few ... your doctor Can a parasite cause death in people and pets? Can human disease from a parasite be treated ...

  5. Heart PET scan

    Science.gov (United States)

    ... nuclear medicine scan; Heart positron emission tomography; Myocardial PET scan ... A PET scan requires a small amount of radioactive material (tracer). This tracer is given through a vein (IV), ...

  6. [Principles of PET].

    Science.gov (United States)

    Beuthien-Baumann, B

    2018-05-01

    Positron emission tomography (PET) is a procedure in nuclear medicine, which is applied predominantly in oncological diagnostics. In the form of modern hybrid machines, such as PET computed tomography (PET/CT) and PET magnetic resonance imaging (PET/MRI) it has found wide acceptance and availability. The PET procedure is more than just another imaging technique, but a functional method with the capability for quantification in addition to the distribution pattern of the radiopharmaceutical, the results of which are used for therapeutic decisions. A profound knowledge of the principles of PET including the correct indications, patient preparation, and possible artifacts is mandatory for the correct interpretation of PET results.

  7. Imagination and Modern Audio Visual Form

    Directory of Open Access Journals (Sweden)

    Ana Đurković

    2017-09-01

    Full Text Available Through three episodes Archetype of modern fairy tales, the mysterious world of fantasy and reality,tell as a serious story about archetypes, symbols, knowledge of good and evil. Rts editor: Natasa Neskovic Written and directed by: Suncica Jergovic Editing: Ana Djurkovic How to illuminate concept of phantasy and affective factors in our imagination a priori something so imaginary, by their genetic provenance, such as a movie scene, or digital picture and sound. You can not always avoid the association to a valid phrase of arnhajm’s truth: mass age -massage: the medium is the message. In elementary and tersely definition of „the shot“ from Plaževsky film language there is term for „le cadre“, however these are selected bits of reality, immanent frame that contains the individual act of images divided of the continent’s view of reality, handling the specific code of semantic value, when its’s imaginative, of course, by aesthetic categories and evaluations. In this type of positive simulacrum, it can not be better segment for the current thinking about the limits of imagination and truth in contemporary media, and contemporary global environment, than the original audio-visual forms through whose prism we search throught a fairy tale in a same time myth and imagination as well as exploring its overall impact on the personality. Everything can be a fairy tale, even false, amoral platitudes politicized by political lobbies in a contemporary existing power sistems, but this is no fairy tale authenticity in it, or creative act, nor humanity and artificial and historical entity of a man that is always present in the ethical effort of a true artist. So, we are investigating the conditions of creative images, modalities of audiovisual media in film language,and it is the archetype of the fairy tale, which, with its psychodynamics still exists and which is removed when the modern man is tired of lies and simulations during his global

  8. Imagining Rural Audiences in Remote Western Australia

    Directory of Open Access Journals (Sweden)

    Lelia Green

    2010-06-01

    Full Text Available In 1979, Australia’s then-Communication Minister Tony Staley commented that the introduction of satellite communications to the bush would “dispel the dis-tance – mental as well as geographical – between urban and regional dwellers, between the haves and the have-nots in a communication society” (Staley 1979: 2225, 2228-9. In saying this, Staley imagined a marginalised and disadvantaged audience of “have-nots”, paying for their isolation in terms of their mental dis-tance from the networked communications of the core. This paper uses ethnographic audience studies surveys and interviews (1986-9 to examine the validity of Staley’s imaginations in terms of four communication technologies: the telephone, broadcast radio, 2-way radio and the satellite. The notion of a mental difference is highly problematic for the remote audience. Inso-far as a perception of lack and of difference is accepted, it is taken to reflect the perspective and the product of the urban policy-maker. Far from accepting the “distance” promulgated from the core, remote audiences see such statements as indicating an ignorance of the complexity and sophistica-tion of communications in an environment where the stakes are higher and the options fewer. This is not to say that remote people were not keen to acquire satel-lite services – they were – it is to say that when they imagined such services it was in terms of equity and interconnections, rather than the “dispelling of distance”.

  9. Gangs and a global sociological imagination.

    Science.gov (United States)

    Fraser, Alistair; Hagedorn, John M

    2018-02-01

    Across the globe, the phenomenon of youth gangs has become an important and sensitive public issue. In this context, an increasing level of research attention has focused on the development of universalized definitions of gangs in a global context. In this article, we argue that this search for similarity has resulted in a failure to recognize and understand difference. Drawing on an alternative methodology we call a 'global exchange', this article suggests three concepts-homologies of habitus, vectors of difference and transnational reflexivity-that seek to re-engage the sociological imagination in the study of gangs and globalization.

  10. Constructing Memory, Imagination, and Empathy: A Cognitive Neuroscience Perspective

    OpenAIRE

    Gaesser, Brendan

    2013-01-01

    Studies on memory, imagination, and empathy have largely progressed in isolation. Consequently, humans’ empathic tendencies to care about and help other people are considered independent of our ability to remember and imagine events. Despite this theoretical autonomy, work from across psychology, and neuroscience suggests that these cognitive abilities may be linked. In the present paper, I tentatively propose that humans’ ability to vividly imagine specific events (as supported by constructi...

  11. Irish Sea Marine Aggregate Initiative (IMAGIN) Technical Synthesis Report

    OpenAIRE

    Sutton, G.

    2008-01-01

    The Irish Sea Marine Aggregates Initiative (IMAGIN) is a collaborative project between Ireland and Wales focused on the sustainable management of marine aggregate resources. IMAGIN was a 2-year project with a total budget of €1.1 million. IMAGIN was part funded (66%) under the Ireland/Wales Inter Regional (INTERREG) IIIA Community Initiative Programme 2000-2006. The remaining project budget was met by contributions from partner organisations (19%) and aggregate companies – CEMEX, Lagan Ltd., ...

  12. Imagining Garage Start-Ups: Interactive Effects of Imaginative Capacities on Entrepreneurial Intention

    Science.gov (United States)

    Chang, Chi-Cheng; Yao, Shu-Nung; Chen, Shi-An; King, Jung-Tai; Liang, Chaoyun

    2016-01-01

    This article describes a structural examination of the interaction among different imaginative capacities and the entrepreneurial intention of electrical and computer engineering students. Two studies were combined to confirm the factor structure of survey items and test the hypothesised interaction model. The results indicated that imaginative…

  13. The Multidimensional Spectrum of Imagination: Images, Dreams, Hallucinations, and Active, Imaginative Perception

    Directory of Open Access Journals (Sweden)

    Nigel J.T. Thomas

    2014-04-01

    Full Text Available A theory of the structure and cognitive function of the human imagination that attempts to do justice to traditional intuitions about its psychological centrality is developed, largely through a detailed critique of the theory propounded by Colin McGinn. Like McGinn, I eschew the highly deflationary views of imagination, common amongst analytical philosophers, that treat it either as a conceptually incoherent notion, or as psychologically trivial. However, McGinn fails to develop his alternative account satisfactorily because (following Reid, Wittgenstein and Sartre he draws an excessively sharp, qualitative distinction between imagination and perception, and because of his flawed, empirically ungrounded conception of hallucination. His arguments in defense of these views are rebutted in detail, and the traditional, passive, Cartesian view of visual perception, upon which several of them implicitly rely, is criticized in the light of findings from recent cognitive science and neuroscience. It is also argued that the apparent intuitiveness of the passive view of visual perception is a result of mere historical contingency. An understanding of perception (informed by modern visual science as an inherently active process enables us to unify our accounts of perception, mental imagery, dreaming, hallucination, creativity, and other aspects of imagination within a single coherent theoretical framework.

  14. [18F]FDG PET/CT outperforms [18F]FDG PET/MRI in differentiated thyroid cancer

    International Nuclear Information System (INIS)

    Vrachimis, Alexis; Wenning, Christian; Weckesser, Matthias; Stegger, Lars; Burg, Matthias Christian; Allkemper, Thomas; Schaefers, Michael

    2016-01-01

    To evaluate the diagnostic potential of PET/MRI with [ 18 F]FDG in comparison to PET/CT in patients with differentiated thyroid cancer suspected or known to have dedifferentiated. The study included 31 thyroidectomized and remnant-ablated patients who underwent a scheduled [ 18 F]FDG PET/CT scan and were then enrolled for a PET/MRI scan of the neck and thorax. The datasets (PET/CT, PET/MRI) were rated regarding lesion count, conspicuity, diameter and characterization. Standardized uptake values were determined for all [ 18 F]FDG-positive lesions. Histology, cytology, and examinations before and after treatment served as the standards of reference. Of 26 patients with a dedifferentiated tumour burden, 25 were correctly identified by both [ 18 F]FDG PET/CT and PET/MRI. Detection rates by PET/CT and PET/MRI were 97 % (113 of 116 lesions) and 85 % (99 of 113 lesions) for malignant lesions, and 100 % (48 of 48 lesions) and 77 % (37 of 48 lesions) for benign lesions, respectively. Lesion conspicuity was higher on PET/CT for both malignant and benign pulmonary lesions and in the overall rating for malignant lesions (p < 0.001). There was a difference between PET/CT and PET/MRI in overall evaluation of malignant lesions (p < 0.01) and detection of pulmonary metastases (p < 0.001). Surgical evaluation revealed three malignant lesions missed by both modalities. PET/MRI additionally failed to detect 14 pulmonary metastases and 11 benign lesions. In patients with thyroid cancer and suspected or known dedifferentiation, [ 18 F]FDG PET/MRI was inferior to low-dose [ 18 F]FDG PET/CT for the assessment of pulmonary status. However, for the assessment of cervical status, [ 18 F]FDG PET/MRI was equal to contrast-enhanced neck [ 18 F]FDG PET/CT. Therefore, [ 18 F]FDG PET/MRI combined with a low-dose CT scan of the thorax may provide an imaging solution when high-quality imaging is needed and high-energy CT is undesirable or the use of a contrast agent is contraindicated. (orig.)

  15. O-15-butanol PET activation study on declarative memory

    International Nuclear Information System (INIS)

    Krause, B.J.; Schmidt, D.; Mottaghy, F.M.; Mueller-Gaertner, H.W.; Forschungszentrum Juelich; Halsband, U.; Tellmann, L.; Herzog, H.

    1998-01-01

    Aim: In this study, neuroanatomical correlates of encoding and retrieval in paired associate learning were evaluated with positron emission tomography using auditorily presented highly imaginable words. Methods: Six right-handed normal male volunteers took part in the study. Each subject underwent six O-15-butanol PET scans. On each of the six trials the memory task began with the injection of a bolus of O-15-butanol. The subjects had to learn and retrieve twelve word pairs (highly imaginable words, not semantically related). The presentation of nonsense words served as reference condition. Results: Recall accuracy after 2-4 presentations was high during the PET measurement. In both encoding and retrieval we found anterior cingulate activation. We show bilateral dorsalateral prefrontal activation during the encoding of auditorily presented word pair associates, whereas retrieval led to left frontal activation. Furthermore, we demonstrate the importance of the precuneus in the retrieval of highly imaginable world-pair associates. Conclusion: Our results support the hypothesis of the presence of distributed widespread brain structures subserving episodic declarative memory. (orig.) [de

  16. Unconscious Imagination and the Mental Imagery Debate

    Directory of Open Access Journals (Sweden)

    Berit Brogaard

    2017-05-01

    Full Text Available Traditionally, philosophers have appealed to the phenomenological similarity between visual experience and visual imagery to support the hypothesis that there is significant overlap between the perceptual and imaginative domains. The current evidence, however, is inconclusive: while evidence from transcranial brain stimulation seems to support this conclusion, neurophysiological evidence from brain lesion studies (e.g., from patients with brain lesions resulting in a loss of mental imagery but not a corresponding loss of perception and vice versa indicates that there are functional and anatomical dissociations between mental imagery and perception. Assuming that the mental imagery and perception do not overlap, at least, to the extent traditionally assumed, then the question arises as to what exactly mental imagery is and whether it parallels perception by proceeding via several functionally distinct mechanisms. In this review, we argue that even though there may not be a shared mechanism underlying vision for perception and conscious imagery, there is an overlap between the mechanisms underlying vision for action and unconscious visual imagery. On the basis of these findings, we propose a modification of Kosslyn’s model of imagery that accommodates unconscious imagination and explore possible explanations of the quasi-pictorial phenomenology of conscious visual imagery in light of the fact that its underlying neural substrates and mechanisms typically are distinct from those of visual experience.

  17. PET/MRI. Methodology and clinical applications

    Energy Technology Data Exchange (ETDEWEB)

    Carrio, Ignasi [Autonomous Univ. of Barcelona, Hospital Sant Pau (Spain). Dept. Medicina Nuclear; Ros, Pablo (ed.) [Univ. Hospitals Case, Medical Center, Cleveland, OH (United States). Dept. of Radiology

    2014-04-01

    Provides detailed information on the methodology and equipment of MRI-PET. Covers a wide range of clinical applications in oncology, cardiology, and neurology. Written by an international group of experts in MRI and PET. PET/MRI is an exciting novel diagnostic imaging modality that combines the precise anatomic and physiologic information provided by magnetic resonance imaging (MRI) with the molecular data obtained with positron emission tomography (PET). PET/MRI offers the promise of a simplified work flow, reduced radiation, whole-body imaging with superior soft tissue contrast, and time of flight physiologic information. It has been described as the pathway to molecular imaging in medicine. In compiling this textbook, the editors have brought together a truly international group of experts in MRI and PET. The book is divided into two parts. The first part covers methodology and equipment and comprises chapters on basic molecular medicine, development of specific contrast agents, MR attenuation and validation, quantitative MRI and PET motion correction, and technical implications for both MRI and PET. The second part of the book focuses on clinical applications in oncology, cardiology, and neurology. Imaging of major neoplasms, including lymphomas and tumors of the breast, prostate, and head and neck, is covered in individual chapters. Further chapters address functional and metabolic cardiovascular examinations and major central nervous system applications such as brain tumors and dementias. Risks, safety aspects, and healthcare costs and impacts are also discussed. This book will be of interest to all radiologists and nuclear medicine physicians who wish to learn more about the latest developments in this important emerging imaging modality and its applications.

  18. Remembering the past and imagining the future in the elderly

    Science.gov (United States)

    Schacter, Daniel L.; Gaesser, Brendan; Addis, Donna Rose

    2013-01-01

    Recent research has demonstrated commonalities between remembering past events and imagining future events. Behavioral studies have revealed that remembering the past and imagining the future depend on shared cognitive processes, whereas neuropsychological and neuroimaging studies have shown that many of the same brain regions are involved in both remembering the past and imagining the future. Here, we review recent cognitive and neuroimaging studies that examine remembering the past and imagining the future in elderly adults. These studies document significant changes in elderly adults’ capacities to imagine future events that are correlated with their memory deficits; most strikingly, older adults tend to remember the past and imagine the future with less episodic detail than younger adults. These findings are in line with the constructive episodic simulation hypothesis, which holds that that past and future events draw on similar information and rely on similar underlying processes, and that episodic memory supports the construction of future events by extracting and recombining stored information into a simulation of a novel event. At the same time, however, recent data indicate that non-episodic factors also contribute to age-related changes in remembering the past and imagining the future. We conclude by considering a number questions and challenges concerning the interpretation of age-related changes in remembering and imagining, as well as functional implications of this research for everyday concerns of older adults. PMID:22987157

  19. Enhancement of suggestibility and imaginative ability with nitrous oxide.

    Science.gov (United States)

    Whalley, M G; Brooks, G B

    2009-05-01

    Imaginative suggestibility, a trait closely related to hypnotic suggestibility, is modifiable under some circumstances. Nitrous oxide (laughing gas) is commonly used for sedation in dentistry and is reported to be more effective when combined with appropriate suggestions. The aim of this study was to determine whether nitrous oxide inhalation alters imaginative suggestibility and imagery vividness. Thirty participants were tested twice in a within-subjects design, once during inhalation of 25% nitrous oxide and once during inhalation of air plus oxygen. Before the study, participants' expectancies regarding the effects of nitrous oxide were assessed. Participants were blinded to drug administration. During each session, participants were verbally administered detailed measures of imagination and suggestibility: the Sheehan-Betts Quality of Mental Imagery scale and the Stanford Hypnotic Susceptibility Scale Form C, minus the hypnotic induction. Imaginative suggestibility and imaginative ability (imagery vividness) were both elevated in the nitrous oxide condition. This effect was unrelated to participants' expectations regarding the effects of the drug. Nitrous oxide increased imaginative suggestibility and imaginative ability. Possible explanations of these findings are discussed with respect to the effects of N-methyl-d-aspartate antagonists and to other pharmacological effects upon suggestibility and imagination.

  20. Using the Sociological Imagination to Teach about Academic Integrity

    Science.gov (United States)

    Nell Trautner, Mary; Borland, Elizabeth

    2013-01-01

    The sociological imagination is a useful tool for teaching about plagiarism and academic integrity, and, in turn, academic integrity is a good case to help students learn about the sociological imagination. ?We present an exercise in which the class discusses reasons for and consequences of dishonest academic behavior and then examines a series of…

  1. Evidence for the Self as an Imaginal Prototype.

    Science.gov (United States)

    Yarmey, A. Daniel; Johnson, Julia

    1982-01-01

    Investigated a set of photographs taken of each subject and self-rated for extent to which each resembled their imagined prototype of "real-self." The findings support the hypothesis of the availability of a memory image schema--the self functions as a cognitive prototype with imaginal and verbal characteristics. (Author/RC)

  2. Young children's imagination in science education and education for sustainability

    Science.gov (United States)

    Caiman, Cecilia; Lundegård, Iann

    2017-09-01

    This research is concerned with how children's processes of imagination, situated in cultural and social practices, come into play when they invent, anticipate, and explore a problem that is important to them. To enhance our understanding of young children's learning and meaning-making related to science and sustainability, research that investigates children's use of imagination is valuable. The specific aim of this paper is to empirically scrutinize how children's imaginations emerge, develop, and impact their experiences in science. We approach imagination as a situated, open, and unscripted act that emerges within transactions. This empirical study was conducted in a Swedish pre-school, and the data was collected `in between' a science inquiry activity and lunchtime. We gathered specific video-sequences wherein the children, lived through the process of imagination, invented a problem together and produced something new. Our analysis showed that imagination has a great significance when children provide different solutions which may be useful in the future to sustainability-related problems. If the purpose of an educational experience in some way supports children's imaginative flow, then practicing an open, listening approach becomes vital. Thus, by encouraging children to explore their concerns and questions related to sustainability issues more thoroughly without incautious recommendations or suggestions from adults, the process of imagination might flourish.

  3. Ethical Imagination in Peace Studies: Beyond the Seville Statement.

    Science.gov (United States)

    Rivage-Seul, M.

    1989-01-01

    Asks reader to look beyond Seville Statement, Social Darwinism, and utopian ideals and come to understand ethical imagination more fully as it relates to peace studies. Examines Seville Statement and its opposition to Social Darwinism. Explains how ethical imagination serves to provide radical alternative to biological determinism. (Author/NB)

  4. Selecting Safe Pets (For Parents)

    Science.gov (United States)

    ... supplies (pet bowls, pet bed, leash, etc.) as gifts, then selecting the pet as a family. That way, everyone has time to really think about whether your family is ready for a pet. Key Questions Before adopting or purchasing any pet, talk to all family members, discuss ...

  5. "Minding the gap": imagination, creativity and human cognition.

    Science.gov (United States)

    Pelaprat, Etienne; Cole, Michael

    2011-12-01

    Inquiry into the nature of mental images is a major topic in psychology where research is focused on the psychological faculties of imagination and creativity. In this paper, we draw on the work of L.S. Vygotsky to develop a cultural-historical approach to the study of imagination as central to human cognitive processes. We characterize imagination as a process of image making that resolves "gaps" arising from biological and cultural-historical constraints, and that enables ongoing time-space coordination necessary for thought and action. After presenting some basic theoretical considerations, we offer a series of examples to illustrate for the reader the diversity of processes of imagination as image making. Applying our arguments to contemporary digital media, we argue that a cultural-historical approach to image formation is important for understanding how imagination and creativity are distinct, yet inter-penetrating processes.

  6. Pet-Related Infections.

    Science.gov (United States)

    Day, Michael J

    2016-11-15

    Physicians and veterinarians have many opportunities to partner in promoting the well-being of people and their pets, especially by addressing zoonotic diseases that may be transmitted between a pet and a human family member. Common cutaneous pet-acquired zoonoses are dermatophytosis (ringworm) and sarcoptic mange (scabies), which are both readily treated. Toxoplasmosis can be acquired from exposure to cat feces, but appropriate hygienic measures can minimize the risk to pregnant women. Persons who work with animals are at increased risk of acquiring bartonellosis (e.g., cat-scratch disease); control of cat fleas is essential to minimize the risk of these infections. People and their pets share a range of tick-borne diseases, and exposure risk can be minimized with use of tick repellent, prompt tick removal, and appropriate tick control measures for pets. Pets such as reptiles, amphibians, and backyard poultry pose a risk of transmitting Salmonella species and are becoming more popular. Personal hygiene after interacting with these pets is crucial to prevent Salmonella infections. Leptospirosis is more often acquired from wildlife than infected dogs, but at-risk dogs can be protected with vaccination. The clinical history in the primary care office should routinely include questions about pets and occupational or other exposure to pet animals. Control and prevention of zoonoses are best achieved by enhancing communication between physicians and veterinarians to ensure patients know the risks of and how to prevent zoonoses in themselves, their pets, and other people.

  7. Bakhtin and Buber: Problems of Dialogic Imagination

    Directory of Open Access Journals (Sweden)

    Nina Perlina

    1984-09-01

    Full Text Available Recent publications of biographical materials on Mikhail Bakhtin demonstrate that he was familiar with the writings of Martin Buber. The philosophical and aesthetic verbal expression of Buber's ideas within the time-spatial universe of Bakhtin's own awareness allows us to discuss this obvious biographical evidence in a wider cultural context. The central opposition of Buber's and Bakhtin's systems is the dialogic dichotomous pair: "Ich und Du" (I and Thou, or "myself and another." Bakhtin's dialogic imagination is rooted in the binaries of the subject-object relations which he initially formulated as "responsibility" and "addressivity," that is to say, as individual awareness and its responsiveness of life. The basic words of Bakhtin's philosophical aesthetics can be understood as the "relation to the other," and their semantics and terminological meaning are directly related to Martin Buber (his work, Ich und Du , 1923. In the 1930s-60s Bakhtin developed the concepts of responsibility and addressivity into his universal dialogic theory of speech-genres. His hierarchy of speech-genres was built in order to establish relations between different sub-genres of the novel (various types of poetic utterances and different species of individual discourse. However, the entire edifice of this dialogic system remained unfinished, and several types of dialogic relations between individual pronouncements of the characters and individual novelistic genres were not discussed by him. Buber's ideas on the dialogue can be used as a clue to one possible interpretation of the function of authoritative and internally persuasive discourses in different sub-genres of the novel (the novel of confession, the Bildungsroman , the autobiographical novel. In this article, Buber's philosophical cycle is used as an aid in reconstructing the integral whole of Bakhtin's "dialogic imagination," as this dialogic mode of thinking goes through his unfinished works: "Author and

  8. Imaginal action: towards a Jungian conception of enactment, and an extraverted counterpart to active imagination.

    Science.gov (United States)

    Brown, Robin S

    2018-04-01

    This theoretical paper considers the fashion in which Jung's psychology radically challenges modern assumptions concerning the nature of subjectivity. With an eye for the clinical implications of Jung's late work, the author introduces the idea of imaginal action. In order to explain what is meant by this, the paper begins by exploring how Jung's thinking demonstrates an underlying bias towards introversion. It is argued that while Jung's interest in synchronicity ultimately resulted in his developing a worldview that might address the introverted biases of his psychology, the clinical implications of this shift have not been sufficiently clarified. With reference to some short examples from experience, the author outlines a conception of relational synchronicity wherein the intrapsychic emerges non-projectively within the interpersonal field itself. Comparing and contrasting these occurrences to the more introverted practice of active imagination, it is claimed that such a notion is implicit in Jung's work and is needed as a corrective to his emphasis on interiority. The author suggests that imaginal action might be conceived as a distinctly Jungian approach to the psychoanalytic notion of enactment. It is also shown how the idea outlined might find further support from recent developments in the field of transpersonal psychology. © 2018, The Society of Analytical Psychology.

  9. Assessment of tumoricidal efficacy and response to treatment with 18F-FDG PET/CT after intraarterial infusion with the antiglycolytic agent 3-bromopyruvate in the VX2 model of liver tumor.

    Science.gov (United States)

    Liapi, Eleni; Geschwind, Jean-Francois H; Vali, Mustafa; Khwaja, Afsheen A; Prieto-Ventura, Veronica; Buijs, Manon; Vossen, Josephina A; Ganapathy-Kanniappan, Shanmugasudaram; Ganapathy, Shanmugasudaram; Wahl, Richard L

    2011-02-01

    The purpose of this study was to determine the effects of 3-bromopyruvate (3-BrPA) on tumor glucose metabolism as imaged with (18)F-FDG PET/CT at multiple time points after treatment and compare them with those after intraarterial control injections of saline. Twenty-three New Zealand White rabbits implanted intrahepatically with VX2 tumors were assigned to 1 of 2 groups: 14 rabbits were assigned to the treatment group (TG) and 9 to the saline control group (SG). All animals were infused with 25 mL of either 1.75 mM 3-BrPA or saline over 1 h via a 2-French catheter, which was secured in the hepatic artery. For PET/CT, the animals were injected with 37 MBq of (18)F-FDG at 1 d before treatment and 2 h, 24 h, and 1 wk after treatment. Tumor size, tumor and liver maximal standardized uptake value (SUV(max)), and tumor-to-background ratios were calculated for all studies. Seven TG and 5 SG animals were sacrificed at 1 wk after treatment for histopathologic analysis. Intense (18)F-FDG uptake was seen in untreated tumors. A significant reduction in tumor SUV(max) was noted in TG animals, when compared with SG animals, at 1 wk after treatment (P = 0.006). The tumor-to-liver background ratio in the TG animals, compared with the SG animals, was significantly reduced as early as 24 h after treatment (P = 0.01) and remained reduced at 1 wk (P = 0.003). Tumor SUV(max) increased from the baseline levels at 7 d in controls (P = 0.05). The histopathologic analysis of explanted livers revealed increased tumor necrosis in all TG samples. There was a significant inverse correlation (r(2) = 0.538, P = 0.005) between the percentage of tumor necrosis on histopathology and tumor SUV(max) on (18)F-FDG PET at 7 d after treatment with 3-BrPA. Intraarterial injection of 3-BrPA resulted in markedly decreased (18)F-FDG uptake as imaged by PET/CT and increased tumor necrosis on histopathology at 1 wk after treatment in the VX2 rabbit liver tumor. PET/CT appears to be a useful means to follow

  10. Evaluation of Dixon Sequence on Hybrid PET/MR Compared with Contrast-Enhanced PET/CT for PET-Positive Lesions

    International Nuclear Information System (INIS)

    Jeong, Ju Hye; Cho, Ihn Ho; Kong, Eun Jung; Chun, Kyung Ah

    2014-01-01

    Hybrid positron emission tomography and magnetic resonance (PET/MR) imaging performs a two-point Dixon MR sequence for attenuation correction. However, MR data in hybrid PET/MR should provide anatomic and morphologic information as well as an attenuation map. We evaluated the Dixon sequence of hybrid PET/MR for anatomic correlation of PET-positive lesions compared with contrast-enhanced PET/computed tomography (CT) in patients with oncologic diseases. Twelve patients underwent a single injection, dual imaging protocol. PET/CT was performed with an intravenous contrast agent (85±13 min after 18 F-FDG injection of 403± 45 MBq) and then (125±19 min after injection) PET/MR was performed. Attenuation correction and anatomic allocation of PET were performed using contrast-enhanced CT for PET/CT and Dixon MR sequence for hybrid PET/MR. The Dixon MR sequence and contrast-enhanced CT were compared for anatomic correlation of PET-positive lesions (scoring scale ranging from 0 to 3 for visual ratings). Additionally, standardized uptake values (SUVs) for the detected lesions were assessed for quantitative comparison. Both hybrid PET/MR and contrast-enhanced PET/CT identified 55 lesions with increased FDG uptake in ten patients. In total, 28 lymph nodes, 11 bone lesions, 3 dermal nodules, 3 pleural thickening lesions, 2 thyroid nodules, 1 pancreas, 1 liver, 1 ovary, 1 uterus, 1 breast, 1 soft tissue and 2 lung lesions were present. The best performance was observed for anatomic correlation of PET findings by the contrast-enhanced CT scans (contrast-enhanced CT, 2.64± 0.70; in-phase, 1.29±1.01; opposed-phase, 1.29±1.15; water-weighted, 1.71±1.07; fat weighted, 0.56±1.03). A significant difference was observed between the scores obtained from the contrast-enhanced CT and all four coregistered Dixon MR images. Quantitative evaluation revealed a high correlation between the SUVs measured with hybrid PET/MR (SUVmean, 2.63±1.62; SUVmax, 4.30±2.88) and contrast-enhanced PET

  11. Evaluation of Dixon Sequence on Hybrid PET/MR Compared with Contrast-Enhanced PET/CT for PET-Positive Lesions

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Ju Hye; Cho, Ihn Ho; Kong, Eun Jung; Chun, Kyung Ah [Yeungnam Univ. Hospital, Daegu (Korea, Republic of)

    2014-03-15

    Hybrid positron emission tomography and magnetic resonance (PET/MR) imaging performs a two-point Dixon MR sequence for attenuation correction. However, MR data in hybrid PET/MR should provide anatomic and morphologic information as well as an attenuation map. We evaluated the Dixon sequence of hybrid PET/MR for anatomic correlation of PET-positive lesions compared with contrast-enhanced PET/computed tomography (CT) in patients with oncologic diseases. Twelve patients underwent a single injection, dual imaging protocol. PET/CT was performed with an intravenous contrast agent (85±13 min after {sup 18}F-FDG injection of 403± 45 MBq) and then (125±19 min after injection) PET/MR was performed. Attenuation correction and anatomic allocation of PET were performed using contrast-enhanced CT for PET/CT and Dixon MR sequence for hybrid PET/MR. The Dixon MR sequence and contrast-enhanced CT were compared for anatomic correlation of PET-positive lesions (scoring scale ranging from 0 to 3 for visual ratings). Additionally, standardized uptake values (SUVs) for the detected lesions were assessed for quantitative comparison. Both hybrid PET/MR and contrast-enhanced PET/CT identified 55 lesions with increased FDG uptake in ten patients. In total, 28 lymph nodes, 11 bone lesions, 3 dermal nodules, 3 pleural thickening lesions, 2 thyroid nodules, 1 pancreas, 1 liver, 1 ovary, 1 uterus, 1 breast, 1 soft tissue and 2 lung lesions were present. The best performance was observed for anatomic correlation of PET findings by the contrast-enhanced CT scans (contrast-enhanced CT, 2.64± 0.70; in-phase, 1.29±1.01; opposed-phase, 1.29±1.15; water-weighted, 1.71±1.07; fat weighted, 0.56±1.03). A significant difference was observed between the scores obtained from the contrast-enhanced CT and all four coregistered Dixon MR images. Quantitative evaluation revealed a high correlation between the SUVs measured with hybrid PET/MR (SUVmean, 2.63±1.62; SUVmax, 4.30±2.88) and contrast

  12. Pets and the immunocompromised person

    Science.gov (United States)

    ... marrow transplant patients and pets; Chemotherapy patients and pets ... Centers for Disease Control and Prevention website. Healthy pets healthy people. www.cdc.gov/healthypets . Updated July 19, 2016. ...

  13. Sensory analysis of pet foods.

    Science.gov (United States)

    Koppel, Kadri

    2014-08-01

    Pet food palatability depends first and foremost on the pet and is related to the pet food sensory properties such as aroma, texture and flavor. Sensory analysis of pet foods may be conducted by humans via descriptive or hedonic analysis, pets via acceptance or preference tests, and through a number of instrumental analysis methods. Sensory analysis of pet foods provides additional information on reasons behind palatable and unpalatable foods as pets lack linguistic capabilities. Furthermore, sensory analysis may be combined with other types of information such as personality and environment factors to increase understanding of acceptable pet foods. Most pet food flavor research is proprietary and, thus, there are a limited number of publications available. Funding opportunities for pet food studies would increase research and publications and this would help raise public awareness of pet food related issues. This mini-review addresses current pet food sensory analysis literature and discusses future challenges and possibilities. © 2014 Society of Chemical Industry.

  14. Enhanced activation of motor execution networks using action observation combined with imagination of lower limb movements.

    Directory of Open Access Journals (Sweden)

    Michael Villiger

    Full Text Available The combination of first-person observation and motor imagery, i.e. first-person observation of limbs with online motor imagination, is commonly used in interactive 3D computer gaming and in some movie scenes. These scenarios are designed to induce a cognitive process in which a subject imagines himself/herself acting as the agent in the displayed movement situation. Despite the ubiquity of this type of interaction and its therapeutic potential, its relationship to passive observation and imitation during observation has not been directly studied using an interactive paradigm. In the present study we show activation resulting from observation, coupled with online imagination and with online imitation of a goal-directed lower limb movement using functional MRI (fMRI in a mixed block/event-related design. Healthy volunteers viewed a video (first-person perspective of a foot kicking a ball. They were instructed to observe-only the action (O, observe and simultaneously imagine performing the action (O-MI, or imitate the action (O-IMIT. We found that when O-MI was compared to O, activation was enhanced in the ventralpremotor cortex bilaterally, left inferior parietal lobule and left insula. The O-MI and O-IMIT conditions shared many activation foci in motor relevant areas as confirmed by conjunction analysis. These results show that (i combining observation with motor imagery (O-MI enhances activation compared to observation-only (O in the relevant foot motor network and in regions responsible for attention, for control of goal-directed movements and for the awareness of causing an action, and (ii it is possible to extensively activate the motor execution network using O-MI, even in the absence of overt movement. Our results may have implications for the development of novel virtual reality interactions for neurorehabilitation interventions and other applications involving training of motor tasks.

  15. Clinical PET application

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Sang Moo; Hong, Song W.; Choi, Chang W.; Yang, Seong Dae [Korea Cancer Center Hospital, Seoul (Korea)

    1997-12-01

    PET gives various methabolic images, and is very important, new diagnostic modality in clinical oncology. In Korea Cancer Center Hospital, PET is installed as a research tool of long-mid-term atomic research project. For the efficient use of PET for clinical and research projects, income from the patients should be managed to get the raw material, equipment, manpower, and also for the clinical PET research. 1. Support the clinical application of PET in oncology. 2. Budgetary management of income, costs for raw material, equipment, manpower, and the clinical PET research project. In this year, 250 cases of PET images were obtained, which resulted total income of 180,000,000 won. 50,000,000 won was deposited for the 1998 PET clinical research. Second year PET clinical research should be managed under unified project. Increased demand for {sup 18}FDG in and outside KCCH need more than 2 times production of {sup 18}FDG in a day purchase of HPLC pump and {sup 68}Ga pin source which was delayed due to economic crisis, should be done early in 1998. (author). 2 figs., 3 tabs.

  16. Imaging with PET system

    International Nuclear Information System (INIS)

    Das, B.K.; Noreen Norfaraheen Lee Abdullah

    2012-01-01

    PET deals with biochemistry and metabolic changes that occur at molecular level. Hence, PET differs fundamentally from other imaging modalities. CT imaging is based on tissue density, whereas MRI conveys anatomic information based on proton density and proton relaxation dynamics. CT and MRI are useful in clinical diagnosis only when disease process has caused significant anatomic alterations. However, in most disease conditions chemical changes precede anatomic changes, that can be detected by PET technology. Thus, PET can provide earliest and unique information about ongoing disease process long before anatomic or structural changes take place. There is no other modality available at present that can replace PET technology. Although PET produces cross-sectional images like that obtained in MRI or CT, they represent circulation, function and metabolism, and not anatomic structure. PET is extremely sensitive measuring quantitatively concentration of tracers in nano to pico-molar range. Thus, PET enables merger of biochemistry and biology in medicine giving birth to molecular medicine that focuses on identifying the molecular errors of disease leading to developing molecular corrections including gene therapy. Molecular imaging with PET has been playing a role in examining the biological nature of a disease condition and its characterization to guide selection and evaluation of treatment. (author)

  17. Imagined Affordance: Reconstructing a Keyword for Communication Theory

    Directory of Open Access Journals (Sweden)

    Peter Nagy

    2015-09-01

    Full Text Available In this essay, we reconstruct a keyword for communication—affordance. Affordance, adopted from ecological psychology, is now widely used in technology studies, yet the term lacks a clear definition. This is especially problematic for scholars grappling with how to theorize the relationship between technology and sociality for complex socio-technical systems such as machine-learning algorithms, pervasive computing, the Internet of Things, and other such “smart” innovations. Within technology studies, emerging theories of materiality, affect, and mediation all necessitate a richer and more nuanced definition for affordance than the field currently uses. To solve this, we develop the concept of imagined affordance. Imagined affordances emerge between users’ perceptions, attitudes, and expectations; between the materiality and functionality of technologies; and between the intentions and perceptions of designers. We use imagined affordance to evoke the importance of imagination in affordances—expectations for technology that are not fully realized in conscious, rational knowledge. We also use imagined affordance to distinguish our process-oriented, socio-technical definition of affordance from the “imagined” consensus of the field around a flimsier use of the term. We also use it in order to better capture the importance of mediation, materiality, and affect. We suggest that imagined affordance helps to theorize the duality of materiality and communication technology: namely, that people shape their media environments, perceive them, and have agency within them because of imagined affordances.

  18. The sociological imagination in a time of climate change

    Science.gov (United States)

    Norgaard, Kari Marie

    2018-04-01

    Despite rising calls for social science knowledge in the face of climate change, too few sociologists have been engaged in the conversations about how we have arrived at such perilous climatic circumstances, or how society can change course. With its attention to the interactive dimensions of social order between individuals, social norms, cultural systems and political economy, the discipline of sociology is uniquely positioned to be an important leader in this conversation. In this paper I suggest that in order to understand and respond to climate change we need two kinds of imagination: 1) to see the relationships between human actions and their impacts on earth's biophysical system (ecological imagination) and 2) to see the relationships within society that make up this environmentally damaging social structure (sociological imagination). The scientific community has made good progress in developing our ecological imagination but still need to develop a sociological imagination. The application of a sociological imagination allows for a powerfully reframing of four key problems in the current interdisciplinary conversation on climate change: why climate change is happening, how we are being impacted, why we have failed to successfully respond so far, and how we might be able to effectively do so. I visit each of these four questions describing the current understanding and show the importance of the sociological imagination and other insights from the field of sociology. I close with reflections on current limitations in sociology's potential to engage climate change and the Anthropocene.

  19. PET/CT in renal, bladder and testicular cancer

    Science.gov (United States)

    Bouchelouche, Kirsten; Physician, Chief; Choyke, Peter L.

    2015-01-01

    Imaging plays an important role in the clinical management of cancer patients. Hybrid imaging with PET/CT is having a broad impact in oncology, and in recent years PET/CT is beginning to have an impact in uro-oncology as well. In both bladder and renal cancer there is a need to study the efficacy of other tracers than F-18 fluorodeoxyglucose (FDG), particularly tracers with only limited renal excretion. Thus, new tracers are being introduced in these malignancies. This review focuses on the clinical role of FDG and other PET agents in renal, bladder and testicular cancer. PMID:26099672

  20. The future of SPECT in a time of PET

    International Nuclear Information System (INIS)

    Jansen, Floris P.; Vanderheyden, Jean-Luc

    2007-01-01

    As positron emission tomography (PET) imaging is becoming more prevalent in clinical practice, it is reasonable to ask if there will be a role for single photon emission computed tomography (SPECT) in the future. This article considers that question, focusing on areas where SPECT can differentiate itself from PET for fundamental reasons: breadth of available radionuclides, simultaneous imaging of multiple agents, cost-effectiveness and adaptability to specific imaging situations. The conclusion is that SPECT will continue to evolve and exist alongside PET and will grow the field of molecular imaging with improved efficiency and patient workflow

  1. Simultaneous (68)Ga-DOTA-TOC PET/MRI with gadoxetate disodium in patients with neuroendocrine tumor.

    Science.gov (United States)

    Hope, Thomas A; Pampaloni, Miguel Hernandez; Nakakura, Eric; VanBrocklin, Henry; Slater, James; Jivan, Salma; Aparici, Carina Mari; Yee, Judy; Bergsland, Emily

    2015-08-01

    To evaluate a simultaneous PET/MRI approach to imaging patients with neuroendocrine tumor using a combination of (68)Ga-DOTA-TOC as a PET contrast agent and gadoxetate disodium as a hepatobiliary MRI contrast agent. Ten patients with neuroendocrine tumor with known or suspected hepatic disease were imaged using a (68)Ga-DOTA-TOC PET/CT immediately followed by a 3.0T time-of-flight PET/MRI, using a combined whole body and liver specific imaging. The presence of lesions and DOTA-TOC avidity were assessed on CT, PET from PET/CT, diffusion weighted imaging, hepatobiliary phase imaging (HBP), and PET from PET/MRI. Maximum standardized uptake values (SUVmax) in hepatic lesions and nodal metastases were compared between PET/CT and PET/MRI, as were detection rates using each imaging approach. A total of 101 hepatic lesions were identified, 47 of which were DOTA-TOC avid and able to be individually measured on both PET/CT and PET/MRI. HBP imaging had a higher sensitivity for detection of hepatic lesions compared to CT or PET (99% vs. 46% and 64%, respectively; p values TOC and gadoxetate disodium was successful in whole body staging of patients with neuroendocrine tumor. HBP imaging had an increased detection rate for hepatic metastases.

  2. Gershwin, Imagination and the Present Day Culture: Art Review

    Directory of Open Access Journals (Sweden)

    Adelaida Berchi Petrancu

    2016-08-01

    Full Text Available In this paper, I analyzed George Gershwin’s musical works and the role of imagination in his musical compositions. In his case, imagination is a new product of his mind. This is in accordance with his interests, purposes and cultural backgrounds. Efforts to appreciate his works should be done in classical terms rather than using some new criteria. Failure to follow these criteria could culminate to relativism, as a result of the decreased role of imagination in today’s art. This bias may lead to imitation.

  3. Evaluation of PET Scanner Performance in PET/MR and PET/CT Systems: NEMA Tests

    OpenAIRE

    Mustafa Demir; Türkay Toklu; Mohammad Abuqbeitah; Hüseyin Çetin; H. Sezer Sezgin; Nami Yeyin; Kerim Sönmezoğlu

    2018-01-01

    Objective: The aim of the present study was to compare the performance of positron emission tomography (PET) component of PET/computed tomography (CT) with new emerging PET/magnetic resonance (MR) of the same vendor. Methods: According to National Electrical Manufacturers Association NU2-07, five separate experimental tests were performed to evaluate the performance of PET scanner of General Electric GE company; SIGNATM model PET/MR and GE Discovery 710 model PET/CT. The main investigated...

  4. Evaluation of PET Scanner Performance in PET/MR and PET/CT Systems: NEMA Tests

    OpenAIRE

    Demir, Mustafa; Toklu, Türkay; Abuqbeitah, Mohammad; Çetin, Hüseyin; Sezgin, H. Sezer; Yeyin, Nami; Sönmezoğlu, Kerim

    2018-01-01

    Objective: The aim of the present study was to compare the performance of positron emission tomography (PET) component of PET/computed tomography (CT) with new emerging PET/magnetic resonance (MR) of the same vendor. Methods: According to National Electrical Manufacturers Association NU2-07, five separate experimental tests were performed to evaluate the performance of PET scanner of General Electric GE company; SIGNATM model PET/MR and GE Discovery 710 model PET/CT. The main investigated asp...

  5. Geografias do mundo imaginário

    Directory of Open Access Journals (Sweden)

    Maria Fernanda Alegria

    2010-06-01

    Full Text Available Geographies of the imagined world. The idea that Geography ismore about the construction of images of the world than about a given “objective reality” inspired this study of the mental representations of several countries. Among the multiple possible representations of 12 countries (Portugal, France, Norway, Egypt,Mauritania, Mozambique, United States, Mexico, Brazil, China, Pakistan and Saudi Arabia, we began by charting their location in a world map as indicated by over 300 respondents with at least high school attendance. Then, the compilation of a vast number of mental images (three per country and respondent led to the definition ofsix general categories that bring together mental images of a similar kind: nature, culture and history, tourism and gastronomy, economy and society, specific places and no answer/wrong answers. In each category, we have highlighted the dominant (most frequentidea. Location, the relative frequency of the no answer/wrong answerscategory and the dominant images for each country all proved significant when it comes to dividing the countries into groups, and serve as indicators of the richness and variety of the mental representations. The study provided answers to some of the original research questions, but leaves many others unanswered.

  6. Ad Oculos. Images, Imagination and Abstract Thinking

    Directory of Open Access Journals (Sweden)

    Alessandra Cirafici

    2018-03-01

    Full Text Available The unusual edition of Elements of Euclid released for publishing in 1847 by Oliver Byrne offers the occasion to suggest a few elements for discussion on the uniqueness of the ‘representation’ of geometric-mathematical thinking—and more in general of the abstract thinking—enshrined in its ‘nature of a pure imaginative vision able to connect the intelligible with the tangible’. The purpose is, thus, a reasoning on images and communicative artefacts, that, when articulated, provide different variations of the idea of ‘transcription’ of complex theoretical structures from one language (that of abstract logic to another (that of sensory experience, with a view to facilitate, ease and make more accurate the noetic process. Images able over time to facilitate the understanding of complex and abstract theoretical principles—since able to show them in an extremely concrete way, ad oculos,—and which at some points could reveal the horizons of art interpretation to inscrutable and figurative meaningless formulas.

  7. Birds Kept as Pets

    Science.gov (United States)

    ... your pet’s health Visit a veterinarian who has experience with pet birds for routine check-ups to keep your bird healthy and prevent infectious diseases. If your bird becomes sick or dies within a month after purchase or adoption: Contact your veterinarian. Inform the pet ...

  8. Model PET Scan Activity

    Science.gov (United States)

    Strunk, Amber; Gazdovich, Jennifer; Redouté, Oriane; Reverte, Juan Manuel; Shelley, Samantha; Todorova, Vesela

    2018-05-01

    This paper provides a brief introduction to antimatter and how it, along with other modern physics topics, is utilized in positron emission tomography (PET) scans. It further describes a hands-on activity for students to help them gain an understanding of how PET scans assist in detecting cancer. Modern physics topics provide an exciting way to introduce students to current applications of physics.

  9. Imagining with the body in analytical psychology. Movement as active imagination: an interdisciplinary perspective from philosophy and neuroscience.

    Science.gov (United States)

    Deligiannis, Ana

    2018-04-01

    This article explores how the body and imagination operate as pathways of knowledge through the use of Movement as Active Imagination in clinical practice. This method activates the transcendent function, thus encouraging new therapeutic responses. A philosophical perspective (Spinoza, Nietzsche, Merleau-Ponty) and some concepts from neuroscience (embodied cognition, somatic markers, image schema, mirror neurons, neuronal plasticity) will accompany us throughout this work, illustrated with a clinical vignette. Three levels of integration: 1) body, 2) body-emotion, 3) body-emotion-imagination are proposed: these mark a progressive sense of articulation and complexity. Finally the relation between creativity and neuronal plasticity will be considered. © 2018, The Society of Analytical Psychology.

  10. 64Cu loaded liposomes as positron emission tomography imaging agents

    DEFF Research Database (Denmark)

    Petersen, Anncatrine Luisa; Binderup, Tina; Rasmussen, Palle

    2011-01-01

    applicable as PET imaging agents. We show the utility of the 64Cu-liposomes for quantitative in vivo imaging of healthy and tumor-bearing mice using PET. This remote loading method is a powerful tool for characterizing the in vivo performance of liposome based nanomedicine, and has great potential...

  11. Influence of the clay in the stress cracking resistance of PET; Influencia de silicatos em camadas na resistencia ao 'stress cracking' do PET

    Energy Technology Data Exchange (ETDEWEB)

    Teofilo, Edvania T. [Programa de Pos-Graduacao em Ciencia e Engenharia de Materiais, Universidade Federal de Campina Grande, PB (Brazil); Silva, Emanuela S.; Silva, Suedina M.L.; Rabello, Marcelo S., E-mail: marcelo@dema.ufcg.edu.b [Unidade Academica de Engenharia de Materiais, Universidade Federal de Campina Grande, PB (Brazil)

    2011-07-01

    The environmental stress cracking resistance in PET and hybrid PET/clay were conducted under stress relaxation test. X-ray diffraction analysis show that was obtained immiscible system. In the absence of aggressive fluids the hybrid exhibited higher relaxation rates than the PET. Already in contact with aggressive fluids showed a similar or lower relaxation rate than the PET, being more resistant. Suggesting that the clay, though not interlayer, interferes with the distribution of the stress cracking agent. Thus, the barrier effect caused by the clay was more significant than the stress concentration caused by it. (author)

  12. Usage of Recycled Pet

    Directory of Open Access Journals (Sweden)

    A. Ebru Tayyar

    2010-01-01

    Full Text Available The increasing industrialization, urbanization and the technological development have caused to increase depletion of the natural resources and environmental pollution's problem. Especially, for the countries which have not enough space recycling of the waste eliminating waste on regular basis or decreasing the amount and volume of waste have provided the important advantages. There are lots of studies and projects to develop both protect resources and prevent environmental pollution. PET bottles are commonly used in beverage industry and can be reused after physical and chemical recycling processes. Usage areas of recycled PET have been developed rapidly. Although recycled PET is used in plastic industry, composite industry also provides usage alternatives of recycled PET. Textile is a suitable sector for recycling of some plastics made of polymers too. In this study, the recycling technologies and applications of waste PET bottles have been investigated and scientific works in this area have been summarized.

  13. Oncology PET imaging

    International Nuclear Information System (INIS)

    Inubushi, Masayuki

    2014-01-01

    At the beginning of this article, likening medical images to 'Where is Waldo?' I indicate the concept of diagnostic process of PET/CT imaging, so that medical physics specialists could understand the role of each imaging modality and infer our distress for image diagnosis. Then, I state the present situation of PET imaging and the basics (e.g. health insurance coverage, clinical significance, principle, protocol, and pitfall) of oncology FDG-PET imaging which accounts for more than 99% of all clinical PET examinations in Japan. Finally, I would like to give a wishful prospect of oncology PET that will expand to be more cancer-specific in order to assess therapeutic effects of emerging molecular targeted drugs targeting the 'hallmarks of cancer'. (author)

  14. Study of ultrasonic imagine of spleen in patients with leukemia

    International Nuclear Information System (INIS)

    Zheng Hui; Zhou Chunyan; Jiang Ju; Luo Liying; Huang Yanhong

    2011-01-01

    To investigate spleen ultrasonic imagine in patients with leukemia and to provide basis information for preventing and treat disease,the spleens imaging of 158 patients with leukemia were detected by B mode ultrasonicgraphy and the data of clinical medical examination were analyzed.The results showed that the spleens' ultrasonic imagine of patients with leukemia were not related to the degree of anemia.The ultrasonic imagines of spleen in patients with chronic leukemia were different to the other kinds of leukemia.The ultrasonic imagine of spleens in leukemia patients are related to types and development of leukemia.The B-ultrasound screening should be used to help clinical diagnosis and treatment of patients with leukemia. (authors)

  15. Designing to support reasoned imagination through embodied metaphor

    NARCIS (Netherlands)

    Antle, A.N. (Alissa); Corness, G.; Bakker, S.; Droumeva, M.; Hoven, van den E.A.W.H.; Bevans, A.; Bryan-Kinns, N.

    2009-01-01

    Supporting users' reasoned imagination in sense making during interaction with tangible and embedded computation involves supporting the application of their existing mental schemata in understanding new forms of interaction. Recent studies that include an embodied metaphor in the interaction model,

  16. A New Measure of Imagination Ability: Anatomical Brain Imaging Correlates

    Directory of Open Access Journals (Sweden)

    Rex Eugene Jung

    2016-04-01

    Full Text Available Imagination involves episodic memory retrieval, visualization, mental simulation, spatial navigation, and future thinking, making it a complex cognitive construct. Prior studies of imagination have attempted to study various elements of imagination (e.g., visualization, but none have attempted to capture the entirety of imagination ability in a single instrument. Here we describe the Hunter Imagination Questionnaire (HIQ, an instrument designed to assess imagination over an extended period of time, in a naturalistic manner. We hypothesized that the HIQ would be related to measures of creative achievement and to a network of brain regions previously identified to be important to imagination/creative abilities. Eighty subjects were administered the HIQ in an online format; all subjects were administered a broad battery of tests including measures of intelligence, personality, and aptitude, as well as structural Magnetic Resonance Imaging (sMR. Responses of the HIQ were found to be normally distributed, and exploratory factor analysis yielded four factors. Internal consistency of the HIQ ranged from .76 to .79, and two factors (Implementation and Learning were significantly related to measures of Creative Achievement (Scientifific - r = .26 and Writing - r = .31 respectively, suggesting concurrent validity. We found that the HIQ and its factors were related to a broad network of brain volumes including increased bilateral hippocampi, lingual gyrus, and caudal/rostral middle frontal lobe, and decreased volumes within the nucleus accumbens and regions within the default mode network (e.g., precuneus, posterior cingulate, transverse temporal lobe. The HIQ was found to be a reliable and valid measure of imagination in a cohort of normal human subjects, and was related to brain volumes previously identified as central to imagination including episodic memory retrieval (e.g., hippocampus. We also identified compelling evidence suggesting imagination

  17. American television fiction transforming Danish teenagers' religious imaginations

    DEFF Research Database (Denmark)

    Petersen, Line Nybro

    2010-01-01

    This paper argues that American television fiction with supernatural themes offers Danish teenage audiences a playground for exploring different religious imaginations in a continuous process of internal negotiations; thereby transforming their imaginations. This process of the mediatization...... narratives. This essay presents the findings of an empirical qualitative study of seventy-two Danish teenagers and considers two primary parameters for the case-based reception study: the teenagers' levels of fandom and their connection with institutionalized religion. In other words, how are religious...

  18. Imagined Voodoo: Terror, Sex, and Racism in American Popular Culture

    OpenAIRE

    McGee, Adam Michael

    2014-01-01

    I analyze the historical and cultural processes by which American racism is reproduced, approaching the issue through the lens of "imagined voodoo" (as distinct from Haitian Vodou). I posit that the American Marine occupation of Haiti (1915-34) was crucial in shaping the American racial imaginary. In film, television, and literature, imagined voodoo continues to serve as an outlet for white racist anxieties. Because it is usually found in low-brow entertainment (like horror) and rarely men...

  19. In Search of an Index of Imagination for Virtual Experience Designers

    Science.gov (United States)

    Liang, Chaoyun; Hsu, Yuling; Chang, Chi-Cheng; Lin, Li-Jhong

    2013-01-01

    Imagination is a gift to humans, and a creative faculty of the mind. Although early studies in the fields of philosophy and psychology appreciated the value of imagination, little work has been done pertaining to indicators of imagination. This study synthesized early works on imagination carried out between 1900 and 2012 to clarify its meaning…

  20. Comparison of first pass bolus AIFs extracted from sequential 18F-FDG PET and DSC-MRI of mice

    International Nuclear Information System (INIS)

    Evans, Eleanor; Sawiak, Stephen J.; Ward, Alexander O.; Buonincontri, Guido; Hawkes, Robert C.; Adrian Carpenter, T.

    2014-01-01

    Accurate kinetic modelling of in vivo physiological function using positron emission tomography (PET) requires determination of the tracer time–activity curve in plasma, known as the arterial input function (AIF). The AIF is usually determined by invasive blood sampling methods, which are prohibitive in murine studies due to low total blood volumes. Extracting AIFs from PET images is also challenging due to large partial volume effects (PVE). We hypothesise that in combined PET with magnetic resonance imaging (PET/MR), a co-injected bolus of MR contrast agent and PET ligand can be tracked using fast MR acquisitions. This protocol would allow extraction of a MR AIF from MR contrast agent concentration–time curves, at higher spatial and temporal resolution than an image-derived PET AIF. A conversion factor could then be applied to the MR AIF for use in PET kinetic analysis. This work has compared AIFs obtained from sequential DSC-MRI and PET with separate injections of gadolinium contrast agent and 18 F-FDG respectively to ascertain the technique′s validity. An automated voxel selection algorithm was employed to improve MR AIF reproducibility. We found that MR and PET AIFs displayed similar character in the first pass, confirmed by gamma variate fits (p<0.02). MR AIFs displayed reduced PVE compared to PET AIFs, indicating their potential use in PET/MR studies

  1. A PET imaging agent with fast kinetics: synthesis and in vivo evaluation of the serotonin transporter ligand [{sup 11}C]2-[2-dimethylaminomethylphenylthio]-5-fluorophenylamine ([{sup 11}C]AFA)

    Energy Technology Data Exchange (ETDEWEB)

    Huang Yiyun E-mail: hh285@columbia.edu; Narendran, Raj; Bae, Sung-A; Erritzoe, David; Guo Ningning; Zhu Zhihong; Hwang, D.-R.; Laruelle, Marc

    2004-08-01

    A new serotonin transporter (SERT) ligand, [{sup 11}C]2-[2-(dimethylaminomethylphenylthio)]-5-fluorophenylamine (10, [{sup 11}C]AFA), was synthesized and evaluated as a candidate PET radioligand in pharmacological and pharmacokinetic studies. As a PET radioligand, AFA (8) can be labeled with either C-11 or F-18. In vitro, AFA displayed high affinity for SERT (K{sub i} 1.46{+-}0.15 nM) and lower affinity for norepinephrine transporter (NET, K{sub i} 141.7{+-}47.4 nM) or dopamine transporter (DAT, K{sub i} >10,000 nM). [{sup 11}C]AFA (10) was prepared from its monomethylamino precursor 9 by reaction with high specific activity [{sup 11}C]methyl iodide. Radiochemical yield was 43{+-}20% based on [{sup 11}C]methyl iodide at end of bombardment (EOB, n = 10) and specific activity was 2,129 {+-} 1,369 Ci/mmol at end of synthesis (EOS, n = 10). Biodistribution studies in rats indicated that [{sup 11}C]AFA accumulated in brain regions known to contain high concentrations of SERT. Binding in SERT-rich brain regions was reduced significantly by pretreatment with either the cold compound 8 or with the selective serotonin reuptake inhibitor (SSRI) citalopram, but not by the selective norepinephrine reuptake inhibitor nisoxetine, thus underlining its in vivo binding selectivity and specificity for SERT. Imaging experiments in baboons demonstrated that the uptake pattern of [{sup 11}C]AFA in the baboon brain is consistent with the known distribution of SERT, with highest activity levels in the midbrain and thalamus, followed by striatum, hippocampus, and cortical regions. Activity levels in the baboon brain peaked at 15-40 min after radioligand injection, indicating a fast uptake kinetics for [{sup 11}C]AFA. Pretreatment of the baboon with citalopram (4 mg/kg) significantly reduced the specific binding of [{sup 11}C]AFA in all SERT-containing brain regions. Kinetic analysis revealed that the regional equilibrium specific to non-specific partition coefficients (V{sub 3}&apos

  2. Imagining sex and adapting to it: different aftereffects after perceiving versus imagining faces.

    Science.gov (United States)

    D'Ascenzo, Stefania; Tommasi, Luca; Laeng, Bruno

    2014-03-01

    A prolonged exposure (i.e., perceptual adaptation) to a male or a female face can produce changes (i.e., aftereffects) in the subsequent gender attribution of a neutral or average face, so that it appears respectively more female or more male. Studies using imagery adaptation and its aftereffects have yielded conflicting results. In the present study we used an adaptation paradigm with both imagined and perceived faces as adaptors, and assessed the aftereffects in judged masculinity/femininity when viewing an androgynous test face. We monitored eye movements and pupillary responses as a way to confirm whether participants did actively engage in visual imagery. The results indicated that both perceptual and imagery adaptation produce aftereffects, but that they run in opposite directions: a contrast effect with perception (e.g., after visual exposure to a female face, the androgynous appears as more male) and an assimilation effect with imagery (e.g., after imaginative exposure to a female face, the androgynous face appears as more female). The pupillary responses revealed dilations consistent with increased cognitive effort during the imagery phase, suggesting that the assimilation aftereffect occurred in the presence of an active and effortful mental imagery process, as also witnessed by the pattern of eye movements recorded during the imagery adaptation phase. Copyright © 2014 Elsevier B.V. All rights reserved.

  3. [18F]FDG PET/MRI vs. PET/CT for whole-body staging in patients with recurrent malignancies of the female pelvis: initial results

    International Nuclear Information System (INIS)

    Beiderwellen, Karsten; Grueneisen, Johannes; Forsting, Michael; Lauenstein, Thomas C.; Umutlu, Lale; Ruhlmann, Verena; Buderath, Paul; Aktas, Bahriye; Heusch, Philipp; Kraff, Oliver

    2015-01-01

    To evaluate the diagnostic potential of PET/MRI with [ 18 F]FDG in recurrent ovarian and cervical cancer in comparison to PET/CT. A group of 19 patients with suspected recurrence of pelvic malignancies (ovarian cancer, 11 patients; cervical cancer, 8 patients) scheduled for an [ 18 F]FDG PET/CT were subsequently enrolled for a PET/MRI. The scan protocol comprised: (1) a T1-W axial VIBE after contrast agent adminstration, (2) an axial T2-W HASTE, (3) a coronal TIRM, (4) an axial DWI, and dedicated MR sequences of the female pelvis including (5) a T1-W VIBE before contrast agent adminstration, (6) a sagittal T2-W TSE, and (7) a sagittal T1-W dynamic VIBE. The datasets (PET/CT, PET/MRI) were rated separately by two readers regarding lesion count, lesion localization, lesion conspicuity (four-point scale), lesion characterization (benign/malignant/indeterminate) and diagnostic confidence (three-point scale). All available data (histology, prior examinations, PET/CT, PET/MRI, follow-up examinations) served as standard of reference. Median values were compared using the Wilcoxon rank sum test. Metastatic lesions were present in 16 of the 19 patients. A total of 78 lesions (malignant, 58; benign, 20) were described. Both PET/CT and PET/MRI allowed correct identification of all malignant lesions and provided equivalent conspicuity (3.86 ± 0.35 for PET/CT, 3.91 ± 0.28 for PET/MRI; p > 0.05). Diagnostic confidence was significantly higher for PET/MRI in malignant (p < 0.01) and benign lesions (p < 0.05). Both PET/CT and PET/MRI offer an equivalently high diagnostic value for recurrent pelvic malignancies. PET/MRI offers higher diagnostic confidence in the discrimination of benign and malignant lesions. Considering the reduced radiation dose and superior lesion discrimination, PET/MRI may serve as a powerful alternative to PET/CT in the future. (orig.)

  4. [{sup 18}F]FDG PET/MRI vs. PET/CT for whole-body staging in patients with recurrent malignancies of the female pelvis: initial results

    Energy Technology Data Exchange (ETDEWEB)

    Beiderwellen, Karsten; Grueneisen, Johannes; Forsting, Michael; Lauenstein, Thomas C.; Umutlu, Lale [University Hospital Essen, University of Duisburg-Essen, Department of Diagnostic and Interventional Radiology and Neuroradiology, Essen (Germany); Ruhlmann, Verena [University Hospital Essen, University of Duisburg-Essen, Clinic for Nuclear Medicine, Essen (Germany); Buderath, Paul; Aktas, Bahriye [University Hospital Essen, University of Duisburg-Essen, Clinic for Obstetrics and Gynecology, Essen (Germany); Heusch, Philipp [University of Dusseldorf, Department of Diagnostic and Interventional Radiology, Dusseldorf (Germany); Kraff, Oliver [University of Duisburg-Essen, Erwin L. Hahn Institute for Magnetic Resonance Imaging, Essen (Germany)

    2015-01-15

    To evaluate the diagnostic potential of PET/MRI with [{sup 18}F]FDG in recurrent ovarian and cervical cancer in comparison to PET/CT. A group of 19 patients with suspected recurrence of pelvic malignancies (ovarian cancer, 11 patients; cervical cancer, 8 patients) scheduled for an [{sup 18}F]FDG PET/CT were subsequently enrolled for a PET/MRI. The scan protocol comprised: (1) a T1-W axial VIBE after contrast agent adminstration, (2) an axial T2-W HASTE, (3) a coronal TIRM, (4) an axial DWI, and dedicated MR sequences of the female pelvis including (5) a T1-W VIBE before contrast agent adminstration, (6) a sagittal T2-W TSE, and (7) a sagittal T1-W dynamic VIBE. The datasets (PET/CT, PET/MRI) were rated separately by two readers regarding lesion count, lesion localization, lesion conspicuity (four-point scale), lesion characterization (benign/malignant/indeterminate) and diagnostic confidence (three-point scale). All available data (histology, prior examinations, PET/CT, PET/MRI, follow-up examinations) served as standard of reference. Median values were compared using the Wilcoxon rank sum test. Metastatic lesions were present in 16 of the 19 patients. A total of 78 lesions (malignant, 58; benign, 20) were described. Both PET/CT and PET/MRI allowed correct identification of all malignant lesions and provided equivalent conspicuity (3.86 ± 0.35 for PET/CT, 3.91 ± 0.28 for PET/MRI; p > 0.05). Diagnostic confidence was significantly higher for PET/MRI in malignant (p < 0.01) and benign lesions (p < 0.05). Both PET/CT and PET/MRI offer an equivalently high diagnostic value for recurrent pelvic malignancies. PET/MRI offers higher diagnostic confidence in the discrimination of benign and malignant lesions. Considering the reduced radiation dose and superior lesion discrimination, PET/MRI may serve as a powerful alternative to PET/CT in the future. (orig.)

  5. How Novelle May Have Shaped Visual Imaginations

    Directory of Open Access Journals (Sweden)

    Patricia Emison

    2016-05-01

    Full Text Available Artists figure fairly frequently in novelle, so it is not unreasonable to suppose that they may have taken more than a passing interest in the genre. Although much scholarly effort has been dedicated to the task of exploring how Horace’s adage “ut pictura poësis” affected the course of the visual arts during the Italian Renaissance and vast scholarly effort has been assigned to the study of Boccaccio’s literary efforts (much more so than the efforts of his successors, relatively little effort has been spent on the dauntingly interdisciplinary task of estimating how the development of prose literary imagination may have affected habits of perception and may also have augmented the project of integrating quotidian observations into pictorial compositions. In contrast to these issues of “realism”, the essay also addresses questions of how the literary conventions of novelle, although they may have been created in deliberate defiance of current social norms, may eventually have helped to shift those norms. More specifically, the gender norms of the novelle offer intriguing precedents for characterizations that we find in the visual arts, from Botticelli to Leonardo to Michelangelo, ones that rarely match what we know of societal expectations of the day. The argument, though necessarily speculative, is addressed as much to the question of how readers and viewers might have had their thinking shaped by their combined aesthetic experiences as by the more traditional question of identifying artists’ sources. Did theorizing about style, or simply thinking about what made for vividness or impressiveness, shift readily between the verbal and the visual, and perhaps more easily then than now? Can we create a history of art that seeks evidence from the whole literary record rather than consistently prioritizing poetry and the “poetic”?

  6. Central Asia in the Iranian geopolitical imagination

    Directory of Open Access Journals (Sweden)

    Edward Wastnidge

    2017-02-01

    Full Text Available This article charts Iran’s relations with Central Asia following the break-up of the Soviet Union in 1991. This event gave Iran a new set of neighbours to the north, and this came at a time when Iran was undergoing changes in the direction of its foreign policy from radical idealistic goals, such as the export of the Islamic Revolution, to more pragmatic aims, including giving priority to its own national interests and pursuing good neighbourly relations. Since 1991, Iran has attempted to develop relations towards the Central Asian states, both bilaterally and through various regional fora. Iran’s actions have been based, in part, on a greater commitment to regionalism that has been evident in Iranian foreign policy since the early 1990s. This has focused on cultivating economic, infrastructural and cultural links with the region, rather than any form of ideological crusade, and has helped reduce Iran’s international isolation. Following a historical contextualisation and explanation of the place that the lands of Central Asia hold in the Iranian geopolitical imagination, the article explores the key concerns of Iran in the region. It will examine Iran’s position on what it perceives as being the key issues shaping its Central Asian diplomacy, namely regional economic cooperation, pipeline politics, the status of the Caspian Sea, security cooperation and cultural diplomacy. This provides a revealing case study of how Iran perceives itself as a vital player in the region, seeking to emphasise the benefits of its geostrategic location, relative stability, and increasing international role following the nuclear deal.

  7. Re-imagining Citizenship, Re-imagining Social Work: U.S. Immigration Policies and Social Work Practice in the Era of AZ SB1070

    Directory of Open Access Journals (Sweden)

    Hye-Kyung Kang

    2012-06-01

    Full Text Available The literature on immigrant cultural citizenship (Ong, 1996; Rosaldo, 1997 has argued that traditional and normative definitions of citizenship ignore various forms of civic participation and belonging and fails to capture the experiences of immigrants in an increasingly globalized world (Getrich, 2008, calling for more nuanced and multiple meanings of citizenship. As agents of civil society, social workers have much power in constructing and maintaining (or resisting normative discourses of citizenship, and how we participate in this process has material consequences for those we serve. Applying poststructural and postcolonial theories, this paper excavates discourses of exclusion and inequity that produce the idea of U.S. citizenship through a critical historical analysis of key U.S. immigration and naturalization-related policies and proposes immigrant cultural citizenship as a conceptual frame for re-imagining social work practice with immigrants.

  8. Erasing fear for an imagined threat event

    NARCIS (Netherlands)

    Soeter, M.; Kindt, M.

    2012-01-01

    Although memory for emotionally arousing and stressful experiences is strong and resistant to change, recent years have witnessed rapidly emerging evidence for the plasticity of fear memories. Upon retrieval a memory may be rendered labile and vulnerable to the disruptive effects of amnestic agents.

  9. PET activation in basal ganglia disorders: Parkinson`s disease and dystonia; PET-Aktivierungsstudien bei Basalganglienerkrankungen: Morbus Parkinson und Dystonien

    Energy Technology Data Exchange (ETDEWEB)

    Ceballos-Baumann, A.O. [Neurologische Klinik, Technische Univ. Muenchen (Germany); Boecker, H. [Neurologische Klinik, Technische Univ. Muenchen (Germany); Conrad, B. [Neurologische Klinik, Technische Univ. Muenchen (Germany)

    1997-03-01

    This article reviews PET activation studies with performance of different motor paradigms (joy-stick movements, imagination of movement, writing) in patients with movement disorders. The focus will be on Parkinson`s disease (PD) and dystonia. PET findings will be related to clinical and electrophysiological observations. PET activation studies before and after therapeutic interventions such as pallidotomy in Parkinson`s disease and botulinum toxin in writer`s cramp are described. The contribution of PET activation studies to the understanding of the pathophysiology of dystonia and PD is discussed. (orig.) [Deutsch] Der Beitrag beschreibt verschiedene PET-Aktivierungsstudien mit motorischen Paradigmen (`joystick`-Bewegungen, Vorstellung von Bewegung, Schreiben) bei Bewegungsstoerungen, im wesentlichen bei Patienten mit Dystonie, einer Hyperkinese, und Morbus Parkinson als Hypokinese. Die experimentellen Befunde werden mit der Klinik in Bezug gebracht. Neue Untersuchungen vor und nach therapeutischen Interventionen, wie die stereotaktische Pallidotomie bei Parkinson und die Botulinum-Toxin-Therapie bei Schreibkrampf, werden beschrieben. Der Beitrag von PET-Aktivierungsstudien zum Verstaendnis der Pathophysiologie von Bewegungsstoerungen wird diskutiert. (orig.)

  10. Evaluation of PET Scanner Performance in PET/MR and PET/CT Systems: NEMA Tests.

    Science.gov (United States)

    Demir, Mustafa; Toklu, Türkay; Abuqbeitah, Mohammad; Çetin, Hüseyin; Sezgin, H Sezer; Yeyin, Nami; Sönmezoğlu, Kerim

    2018-02-01

    The aim of the present study was to compare the performance of positron emission tomography (PET) component of PET/computed tomography (CT) with new emerging PET/magnetic resonance (MR) of the same vendor. According to National Electrical Manufacturers Association NU2-07, five separate experimental tests were performed to evaluate the performance of PET scanner of General Electric GE company; SIGNATM model PET/MR and GE Discovery 710 model PET/CT. The main investigated aspects were spatial resolution, sensitivity, scatter fraction, count rate performance, image quality, count loss and random events correction accuracy. The findings of this study demonstrated superior sensitivity (~ 4 folds) of PET scanner in PET/MR compared to PET/CT system. Image quality test exhibited higher contrast in PET/MR (~ 9%) compared with PET/CT. The scatter fraction of PET/MR was 43.4% at noise equivalent count rate (NECR) peak of 218 kcps and the corresponding activity concentration was 17.7 kBq/cc. Whereas the scatter fraction of PET/CT was found as 39.2% at NECR peak of 72 kcps and activity concentration of 24.3 kBq/cc. The percentage error of the random event correction accuracy was 3.4% and 3.1% in PET/MR and PET/CT, respectively. It was concluded that PET/MR system is about 4 times more sensitive than PET/CT, and the contrast of hot lesions in PET/MR was ~ 9% higher than PET/CT. These outcomes also emphasize the possibility to achieve excellent clinical PET images with low administered dose and/or a short acquisition time in PET/MR.

  11. Positron Emission Tomography (PET)

    International Nuclear Information System (INIS)

    Rollo, F.D.; Hines, H.

    2001-01-01

    ADAC Laboratories has two main imaging strengths: PET and Gamma Cameras. PET's three-dimensional imaging of metabolic function is used in oncology, with emerging opportunties in cardiology, genetic mapping and pharmaceuticals research. In oncology, PET imaging can provide comprehensive and accurate staging information which is not available from CT or MRI. In some cases, this information can lead to modification of treatment, for example from an aggressive approach to one of palliation. The SKYLight is the world's first and only gantry-free camera. It is a dual-detector variable angle camera designed for high throughput, with unsurpassed openness and patient access. (orig.)

  12. Biological Agents

    Science.gov (United States)

    ... E-Tools Safety and Health Topics / Biological Agents Biological Agents This page requires that javascript be enabled ... 202) 693-2300 if additional assistance is required. Biological Agents Menu Overview In Focus: Ebola Frederick A. ...

  13. Translator’s inferential excursions, with imagination in the background

    Directory of Open Access Journals (Sweden)

    Bożena Tokarz

    2014-01-01

    Full Text Available In a literary work, signals that trigger reader’s inferential excursions allow the reader’s imagination to identify with and control the represented world. They constitute an important element of sense-generating mechanism. Thanks to imagination, the translator imitates the inferential mechanism of the original on various level’s of the text’s structure, activating the imagination of the reader. The translator’s imagination is bi- or multivalent in having the linguistic-semiotic, literary, and cultural quality. Although it manifests itself in language, it goes beyond the boundaries of language. Imagination is a form of consciousness which has no object of its own, and a medium connecting a specific non-imaginary knowledge with representations. It constitutes a mind faculty shaped on the basis of sensory and mental perception. It is derived from individual principles of perception and cognition data processing. It usually requires a stymulus to activate the capabilities of the imagining subject. As a mind faculty, imagination is based on the mental capability common to all people, which is the ability to create chains of associations.Translator’s respect for inferential excursions in the original text is necessary for retaining the original meaning, regardless of whether they occur on the phonetic-phonological level (as in Ionesco’s The Chairs, or on the level of image-semantic and syntactic relations (as in translation of Apollinaire’s Zone, or on the level of syntax (as in translation of Mrożek’s short stories into Slovenian, or on the level of cultural communication (as in Slovenian translation of Gombrowicz’s Trans-Atlantic.

  14. Development of PET in Latin America. Experience of the first PET-Cyclotron Center

    International Nuclear Information System (INIS)

    Tutor, C.A.; Frias, L.

    2002-01-01

    Aim: Describe the experience of the first PET-Cyclotron Center in Latin America. Demonstrate the viability of running a PET Center in Argentina despite the economic crisis. Materials and Methods: For this study, we used a UGM/GE Quest 250 PET scan, a RDS 112 cyclotron and a Radiosynthesis Laboratory installed at the (FUESMEN) Nuclear Medicine School Foundation, located in Mendoza City, in the middle-west of Argentina. From January 1999 to March 2002, 741 studies were obtained, 731 were 18 FluorDeoxyGlucose-PET studies and 10 phantoms for calibration purposes. We used acquisition and imaging processing standard protocols, as well as research protocols designed according to the pathology under investigation. To better correlate anatomical and functional images, we used fusion techniques with (CT) Computed Tomography in some (WB) whole-body PET scans. Results: A total of 731 patients were retrospectively analyzed and classified according to statistics variables such as: 1-sex: 317 women and 414 men, 2-type of scan: 439 WB cases, 267 brain studies and 25 cardiac. From this data we divided them as PET indications and resulted in 17 cases as healthy volunteers, 422 oncological cases, 267 neurological studies and 25 cardiac for myocardial viability. According to the origin they were classified as patients coming from Mendoza 544, Buenos Aires 112, other argentine provinces 60 and foreign (Chile, Brazil and Uruguay) 15 cases. In terms of billing, 181 studies were done free of charge, 95 under research protocols were also done free of charge and 451 were charged. Conclusion: Not only the economical and political factors play an important role limiting the advances of PET Imaging in Latin America, but also the lack of a neighboring cyclotron that circumscribe many hospitals to have access to the radiopharmaceutical agent. FUESMEN was established in 1991 by three governmental entities: the (CONEA) National Commission of Atomic Energy, the (UNC) National University of Cuyo and

  15. [{sup 18}F]FDG PET/CT outperforms [{sup 18}F]FDG PET/MRI in differentiated thyroid cancer

    Energy Technology Data Exchange (ETDEWEB)

    Vrachimis, Alexis; Wenning, Christian; Weckesser, Matthias; Stegger, Lars [University Hospital Muenster, Department of Nuclear Medicine, Muenster (Germany); Burg, Matthias Christian; Allkemper, Thomas [University Hospital Muenster, Department of Clinical Radiology, Muenster (Germany); Schaefers, Michael [University Hospital Muenster, Department of Nuclear Medicine, Muenster (Germany); Westfaelische Wilhelms University Muenster, European Institute for Molecular Imaging, Muenster (Germany)

    2016-02-15

    To evaluate the diagnostic potential of PET/MRI with [{sup 18}F]FDG in comparison to PET/CT in patients with differentiated thyroid cancer suspected or known to have dedifferentiated. The study included 31 thyroidectomized and remnant-ablated patients who underwent a scheduled [{sup 18}F]FDG PET/CT scan and were then enrolled for a PET/MRI scan of the neck and thorax. The datasets (PET/CT, PET/MRI) were rated regarding lesion count, conspicuity, diameter and characterization. Standardized uptake values were determined for all [{sup 18}F]FDG-positive lesions. Histology, cytology, and examinations before and after treatment served as the standards of reference. Of 26 patients with a dedifferentiated tumour burden, 25 were correctly identified by both [{sup 18}F]FDG PET/CT and PET/MRI. Detection rates by PET/CT and PET/MRI were 97 % (113 of 116 lesions) and 85 % (99 of 113 lesions) for malignant lesions, and 100 % (48 of 48 lesions) and 77 % (37 of 48 lesions) for benign lesions, respectively. Lesion conspicuity was higher on PET/CT for both malignant and benign pulmonary lesions and in the overall rating for malignant lesions (p < 0.001). There was a difference between PET/CT and PET/MRI in overall evaluation of malignant lesions (p < 0.01) and detection of pulmonary metastases (p < 0.001). Surgical evaluation revealed three malignant lesions missed by both modalities. PET/MRI additionally failed to detect 14 pulmonary metastases and 11 benign lesions. In patients with thyroid cancer and suspected or known dedifferentiation, [{sup 18}F]FDG PET/MRI was inferior to low-dose [{sup 18}F]FDG PET/CT for the assessment of pulmonary status. However, for the assessment of cervical status, [{sup 18}F]FDG PET/MRI was equal to contrast-enhanced neck [{sup 18}F]FDG PET/CT. Therefore, [{sup 18}F]FDG PET/MRI combined with a low-dose CT scan of the thorax may provide an imaging solution when high-quality imaging is needed and high-energy CT is undesirable or the use of a contrast

  16. PET studies in epilepsy

    Science.gov (United States)

    Sarikaya, Ismet

    2015-01-01

    Various PET studies, such as measurements of glucose, serotonin and oxygen metabolism, cerebral blood flow and receptor bindings are availabe for epilepsy. 18Fluoro-2-deoxyglucose (18F-FDG) PET imaging of brain glucose metabolism is a well established and widely available technique. Studies have demonstrated that the sensitivity of interictal FDG-PET is higher than interictal SPECT and similar to ictal SPECT for the lateralization and localization of epileptogenic foci in presurgical patients refractory to medical treatments who have noncontributory EEG and MRI. In addition to localizing epileptogenic focus, FDG-PET provide additional important information on the functional status of the rest of the brain. The main limitation of interictal FDG-PET is that it cannot precisely define the surgical margin as the area of hypometabolism usually extends beyond the epileptogenic zone. Various neurotransmitters (GABA, glutamate, opiates, serotonin, dopamine, acethylcholine, and adenosine) and receptor subtypes are involved in epilepsy. PET receptor imaging studies performed in limited centers help to understand the role of neurotransmitters in epileptogenesis, identify epileptic foci and investigate new treatment approaches. PET receptor imaging studies have demonstrated reduced 11C-flumazenil (GABAA-cBDZ) and 18F-MPPF (5-HT1A serotonin) and increased 11C-cerfentanil (mu opiate) and 11C-MeNTI (delta opiate) bindings in the area of seizure. 11C-flumazenil has been reported to be more sensitive than FDG-PET for identifying epileptic foci. The area of abnormality on GABAAcBDZ and opiate receptor images is usually smaller and more circumscribed than the area of hypometabolism on FDG images. Studies have demonstrated that 11C-alpha-methyl-L-tryptophan PET (to study synthesis of serotonin) can detect the epileptic focus within malformations of cortical development and helps in differentiating epileptogenic from non-epileptogenic tubers in patients with tuberous sclerosis complex

  17. Influence of the clay in the stress cracking resistance of PET

    International Nuclear Information System (INIS)

    Teofilo, Edvania T.; Silva, Emanuela S.; Silva, Suedina M.L.; Rabello, Marcelo S.

    2011-01-01

    The environmental stress cracking resistance in PET and hybrid PET/clay were conducted under stress relaxation test. X-ray diffraction analysis show that was obtained immiscible system. In the absence of aggressive fluids the hybrid exhibited higher relaxation rates than the PET. Already in contact with aggressive fluids showed a similar or lower relaxation rate than the PET, being more resistant. Suggesting that the clay, though not interlayer, interferes with the distribution of the stress cracking agent. Thus, the barrier effect caused by the clay was more significant than the stress concentration caused by it. (author)

  18. PET and Recycling

    OpenAIRE

    Funda Sevencan; Songul A. Vaizoglu

    2007-01-01

    This review aims to clarify the need of decreasing the environmental effects caused by human and draw attention to the increasing environmental effects of plastics wastes. Plastics consist of organic molecules with high density molecules or polymers. Main resources of plastics are the residue of oil rafineries. Several advantages of plastics, have increased the usage continuously. Polyethylene Terephthalate (PET) is the most commonly used plastics. PET is used to protect food, drinking water,...

  19. Sex differences in components of imagined perspective transformation.

    Science.gov (United States)

    Gardner, Mark R; Sorhus, Ingrid; Edmonds, Caroline J; Potts, Rosalind

    2012-05-01

    Little research to date has examined whether sex differences in spatial ability extend to the mental self rotation involved in taking on a third party perspective. This question was addressed in the present study by assessing components of imagined perspective transformations in twenty men and twenty women. Participants made speeded left-right judgements about the hand in which an object was held by front- and back- facing schematic human figures in an "own body transformation task." Response times were longer when the figure did not share the same spatial orientation as the participant, and were substantially longer than those made for a control task requiring left-right judgements about the same stimuli from the participant's own point of view. A sex difference in imagined perspective transformation favouring males was found to be restricted to the speed of imagined self rotation, and was not observed for components indexing readiness to take a third party point of view, nor in left-right confusion. These findings indicate that the range of spatial abilities for which a sex difference has been established should be extended to include imagined perspective transformations. They also suggest that imagined perspective transformations may not draw upon those empathic social-emotional perspective taking processes for which females show an advantage. Copyright © 2012 Elsevier B.V. All rights reserved.

  20. Of Eden and Nazareth: Stories to capture the imagination

    Directory of Open Access Journals (Sweden)

    Yolande Steenkamp

    2017-01-01

    Full Text Available In pursuit of counter-traditions that have read the Eden narrative without subscribing to the Christian fall�redemption paradigm, this article engages Richard Kearney�s hermeneutical� phenomenological reading of the imagination to explore new avenues for imagining sin and salvation along post-metaphysical lines. The first section provides insights proceeding from an intratextual reading of the Eden narrative. The second section proceeds to incorporate the biblical and rabbinical concept of the yetser to elaborate the reading described above. The section follows Kearney�s reading of the Eden narrative to elicit the imagination along ethical lines as humanity�s passion for the possible. The third section reads the annunciation narrative along these same lines, illustrating how a divine kingdom of justice and love is possibilised by an imagination captured by divine promise and hospitality. By reading these two narratives together through the lense of the imagination, novel ways of rethinking sin and salvation along post-metaphysical lines emerge that portray salvation as human participation in God�s ongoing creation of justice and love, thus enabling the God Who May Be.Intradisciplinary and/or interdisciplinary implications: This article is relevant to the fields of philosophy, philosophy of religion and theology. The narratives of fall and promise, previously read by philosopher Richard Kearney in different contexts and not in relation to one another, are read here from a decidedly theological point of view.

  1. What imagination can teach us about higher mental functions

    DEFF Research Database (Denmark)

    Tateo, Luca

    2016-01-01

    The chapter uses the history of the concept of imagination as example of how psychology creates a normative model of mental processes that affects our understanding of development. Following the traditional hierarchy of psychological functions, with abstract rationality on top, we fail to underst......The chapter uses the history of the concept of imagination as example of how psychology creates a normative model of mental processes that affects our understanding of development. Following the traditional hierarchy of psychological functions, with abstract rationality on top, we fail...... in fictional world where we can find relief to the disquieting spectacle of the world, nor a sandbox in which we can play with alternative futures. It is one of the higher mental functions that makes the world how we experience it and how we are striving to experience it. The imaginative process plays a self...

  2. When imagining future wealth influences risky decision making

    Directory of Open Access Journals (Sweden)

    Adam Eric Greenberg

    2013-05-01

    Full Text Available The body of literature on the relationship between risk aversion and wealth is extensive. However, little attention has been given to examining how future realizations of wealth might affect (current risk decisions. Using paired lottery choice experiments and exposing subjects experimentally to imagined future wealth frames, I find that individuals are more risk-seeking if they are asked to imagine that they will be wealthy in the future. Yet I find that individuals are not significantly more risk-averse if they are asked to imagine that they will be poor in the future. I discuss theoretical and policy implications of these findings, including why savings rates are so low in the United States.

  3. Burkholderia pseudomallei isolates in 2 pet iguanas, California, USA.

    Science.gov (United States)

    Zehnder, Ashley M; Hawkins, Michelle G; Koski, Marilyn A; Lifland, Barry; Byrne, Barbara A; Swanson, Alexandra A; Rood, Michael P; Gee, Jay E; Elrod, Mindy Glass; Beesley, Cari A; Blaney, David D; Ventura, Jean; Hoffmaster, Alex R; Beeler, Emily S

    2014-02-01

    Burkholderia pseudomallei, the causative agent of melioidosis, was isolated from abscesses of 2 pet green iguanas in California, USA. The international trade in iguanas may contribute to importation of this pathogen into countries where it is not endemic and put persons exposed to these animals at risk for infection.

  4. Burkholderia pseudomallei Isolates in 2 Pet Iguanas, California, USA

    OpenAIRE

    Zehnder, Ashley M.; Hawkins, Michelle G.; Koski, Marilyn A.; Lifland, Barry; Byrne, Barbara A.; Swanson, Alexandra A.; Rood, Michael P.; Gee, Jay E.; Elrod, Mindy Glass; Beesley, Cari A.; Blaney, David D.; Ventura, Jean; Hoffmaster, Alex R.; Beeler, Emily S.

    2014-01-01

    Burkholderia pseudomallei, the causative agent of melioidosis, was isolated from abscesses of 2 pet green iguanas in California, USA. The international trade in iguanas may contribute to importation of this pathogen into countries where it is not endemic and put persons exposed to these animals at risk for infection.

  5. Leadership and Moral Imagination: Beyond the Decision-making Context

    Directory of Open Access Journals (Sweden)

    Alan Preti

    2014-12-01

    Full Text Available Moral imagination is often viewed as a necessary condition for ethical leadership on account of its role in managerial decision-making and organizational management. This article argues that an extension of the notion beyond this limited context sheds light on recent reconceptualizations of the nature of business and the relation of business and society proffered by several well-known business leaders. It is suggested that an account of moral imagination which takes into consideration its contribution to the development of a morally deeper and broader perspective and its bearing on character is of particular value for business leaders.

  6. ``Feeling more regret than I would have imagined''

    Directory of Open Access Journals (Sweden)

    Diego Fernandez-Duque

    2008-08-01

    Full Text Available People tend to overestimate emotional responses to future events. This study examined whether such affective forecasting errors occur for feelings of regret, as measured by self-report and subsequent decision-making. Some participants played a pricing game and lost by a narrow or wide margin, while others were asked to imagine losing by such margins. Participants who experienced a narrow loss reported more regret than those who imagined a narrow loss. Furthermore, those experiencing a narrow loss behaved more cautiously in a subsequent gambling task. Thus, the study provides self-report and behavioral evidence for a reversal of the affective forecasting phenomenon for feelings of regret.

  7. The role of the imagination in museum visits

    DEFF Research Database (Denmark)

    Achiam, Marianne

    2016-01-01

    The imagination plays an important role in museums, today more than ever. Visitors use their repositories of imagination or repertoires to make sense of their encounters with objects and exhibits. In this article, I argue that this initial meaning making, rather than being the end goal of museum...... that becoming familiar with commonly occurring repertoires is necessary for exhibition designers in order for museums to continue to take their interpretive responsibility seriously, and I discuss how such a familiarisation may affect museum practice. I conclude with some perspectives on the implications...

  8. Empathy Examined From Perspectives of Neuroscience and Artistic Imagination.

    Science.gov (United States)

    Franklin, Michael A; Grossenbacher, Peter G

    2016-01-01

    This response to Ian E. Wickramasekera II's article, Mysteries of Hypnosis and the Self Are Revealed by the Psychology and Neuroscience of Empathy, is addressed from a joint perspective on consciousness comprising two related orientations: neuroscience and artistic imagination. We find that the central importance of empathy to empathic involvement theory (Wickramasekera II, 2015) reflects the pivotal nature of empathy in the brain and in the relational exchange implicit in the psychotherapeutic process, particularly when using art in therapy. We offer a preliminary unpacking of the roles related to key psychological processes, such as imagination, that are implicated in clinical uses of verbal and visual empathic resonance.

  9. Synthesis of carbon-11 labeled 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinolinium derivatives as new potential PET SKCa channel imaging agents.

    Science.gov (United States)

    Gao, Mingzhang; Wang, Min; Zheng, Qi-Huang

    2008-02-01

    Small conductance Ca2+-activated K+ (SKCa) channels play an important role in many functions such as neuronal communication and behavioral plasticity, secretion, and cell proliferation. SKCa channel modulation is associated with various brain, heart, and cancer diseases. N-methyl-laudanosine and its structurally related derivatives, substituted 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinoliniums, are reversible and selective SKCa channel blockers. Carbon-11 labeled N-methyl-laudanosine and its tetrahydroisoquinolinium derivatives may serve as new probes for positron emission tomography (PET) to image SKCa channels in the brain, heart, and cancer. The key intermediates, substituted isoquinolines (3a-c), were synthesized using a modification of the Pomeranz-Fritsch procedure. The precursors, substituted 1-(3,4-dimethoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolines (8a-c), and their corresponding reference standards, substituted 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinoliniums (9a-c), were synthesized from compounds 3a-c with 3,4-dimethoxybenzyl chloride (2) in multiple steps with moderate to excellent chemical yields. The precursor 6,7-dimethoxy-1-(3,4-dimethoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline (10) was commercially available, and the methylation of compound 10 with methyl iodide provided N-methyl-laudanosine (11). The target quaternary ammonium tracers, carbon-11 labeled 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinoliniums ([11C]9a-c and [11C]11), were prepared by N-[11C]methylation of the tertiary amine precursors (8a-c and 10) with [11C]methyl triflate and isolated by a simplified solid-phase extraction (SPE) purification using a SiO2 or cation-exchange CM Sep-Pak cartridge in 40-65% radiochemical yields.

  10. Medical application of PET technology

    International Nuclear Information System (INIS)

    Lim, Sang Moo; Choi, C. W.; An, S. H.; Woo, K. S.; Chung, W. S.; Yang, S. D.; Jun, G. S. and others

    1999-04-01

    We performed following studies using PET technology: 1. Clinical usefulness of [ 18 F]FDG whole body PET in malignant disease 2. Clinical usefulness of quantitative evaluation of F-18-FDG 3. Pilot study of C-11 methionine PET in brain tumor 4. PET study in patients with Parkinson's disease 5. A study on the clinical myocardial PET image. PET gives various metabolic information for the living human body, and is very important, new diagnostic modality. The PET study will give us the information of cancer patients such as early detection of cancer, staging, recurrence detection and characterization of cancer. The quantitative analysis using PET could be applied to evaluate the pathophysiology of various diseases and develop new drugs and develop new radiopharmaceuticals

  11. PET in neuro-oncology

    NARCIS (Netherlands)

    Roelcke, U; Leenders, K.L.

    This article reviews possible clinical applications of positron emission tomography (PET) in brain tumor patients. PET allows quantitative assessment of brain tumor pathophysiology and biochemistry. It therefore provides different information about tumors when compared to histological or

  12. Take Care with Pet Reptiles

    Science.gov (United States)

    ... young children. [775 KB] Animals and Health Healthy Pets Healthy People : CDC website with helpful resources and information on health benefits of pets and disease risks Safe Handling Tips for Reptiles ...

  13. Medical application of PET technology

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Sang Moo; Choi, C. W.; An, S. H.; Woo, K. S.; Chung, W. S.; Yang, S. D.; Jun, G. S. and others

    1999-04-01

    We performed following studies using PET technology: 1. Clinical usefulness of [{sup 18}F]FDG whole body PET in malignant disease 2. Clinical usefulness of quantitative evaluation of F-18-FDG 3. Pilot study of C-11 methionine PET in brain tumor 4. PET study in patients with Parkinson's disease 5. A study on the clinical myocardial PET image. PET gives various metabolic information for the living human body, and is very important, new diagnostic modality. The PET study will give us the information of cancer patients such as early detection of cancer, staging, recurrence detection and characterization of cancer. The quantitative analysis using PET could be applied to evaluate the pathophysiology of various diseases and develop new drugs and develop new radiopharmaceuticals.

  14. PET applications in pediatrics

    Energy Technology Data Exchange (ETDEWEB)

    Shulkin, B. L. [Ann Arbor, Univ. of Michigan Medical Center (United States). Pediatric Nuclear Medicine Section

    1997-12-01

    This article summarizes the major PET studies which have been performed in pediatric patients to elucidate and characterize diseases and normal development. Issues special for the application of the technique in children, such as dosimetry, patient preparation, and image acquisition are discussed. Studies of central nervous system (CNS) development and pathology, including epilepsy, intraventricular hemorrhage, neonatal asphyxia, tumors, and effects on the CNS from treatment of other tumors are reviewed. These have contributed information fundamental to their understanding of CNS development and pathology. PET investigations into the pathophysiology of congenital heart disease have begun and hold great promise to aid their understanding of these conditions. The second major area in which PET has been applied is the study of non CNS neoplasms. Neuroblastoma has been investigated with tracers which explore basic biochemical features which characterize this tumor, as well as with tracers which explore biochemical events relatively specific for this malignancy. Other common and uncommon tumors of childhood are discussed. The PET technique has been shown useful for answering questions of clinical relevance for the management of these uncommon neoplasms. PET is likely to continue to aid their understanding of many pediatric diseases and may gain more widespread clinical acceptance as the technology continues to disseminate rapidly.

  15. Combined PET/MRI

    DEFF Research Database (Denmark)

    Bailey, D L; Pichler, B J; Gückel, B

    2018-01-01

    The 6th annual meeting to address key issues in positron emission tomography (PET)/magnetic resonance imaging (MRI) was held again in Tübingen, Germany, from March 27 to 29, 2017. Over three days of invited plenary lectures, round table discussions and dialogue board deliberations, participants c...... of response to pharmacological interventions and therapies. As such, PET/MRI is a key to advancing medicine and patient care.......The 6th annual meeting to address key issues in positron emission tomography (PET)/magnetic resonance imaging (MRI) was held again in Tübingen, Germany, from March 27 to 29, 2017. Over three days of invited plenary lectures, round table discussions and dialogue board deliberations, participants...... critically assessed the current state of PET/MRI, both clinically and as a research tool, and attempted to chart future directions. The meeting addressed the use of PET/MRI and workflows in oncology, neurosciences, infection, inflammation and chronic pain syndromes, as well as deeper discussions about how...

  16. Dosimetry of FDG PET/CT and other molecular imaging applications in pediatric patients

    International Nuclear Information System (INIS)

    Gelfand, Michael J.

    2009-01-01

    Effective doses for PET and SPECT imaging of molecular imaging agents depend on the radiopharmaceutical, administered activity and the weight of the patient. Effective doses for the accompanying CT scan depend on the CT protocol being used. CT protocols can be designed to produce diagnostic quality images, localization images or attenuation correction data without imaging. In each case, the co-registered molecular imaging examination (PET or SPECT) and the CT study must be acquired without patient movement. For PET/CT, attention to the respiratory phase during the CT study is also of critical importance. In addition to the molecular imaging agents 18 F-FDG and 123 I-MIBG that are frequently used in children, additional PET and SPECT imaging agents may have promise for molecular imaging in children. (orig.)

  17. PET imaging in multiple sclerosis

    NARCIS (Netherlands)

    Faria, Daniele de Paula; Copray, Sjef; Buchpiguel, Carlos; Dierckx, Rudi; de Vries, Erik

    Positron emission tomography (PET) is a non-invasive technique for quantitative imaging of biochemical and physiological processes in animals and humans. PET uses probes labeled with a radioactive isotope, called PET tracers, which can bind to or be converted by a specific biological target and thus

  18. PET imaging of inflammation

    International Nuclear Information System (INIS)

    Buscombe, J. R.

    2014-01-01

    Inflammatory diseases are common place and often chronic. Most inflammatory cells have increased uptake of glucose which is enhanced in the presence of local cytokines. Therefore, imaging glucose metabolism by the means of 18F-fluoro-deoxy-glucose (FDG) positron emission tomography (PET) holds significant promise in imaging focal inflammation. Most of the work published involved small series of patients with either vasculitis, sarcoid or rheumatoid arthritis. It would appear that FDG PET is a simple and effective technique to identify inflammatory tissue in these conditions. There is even some work to suggest that by comparing baseline and early post therapy scans clinical outcome can be predicted. This would appear to be true with vasculitis as well as retroperitoneal fibrosis. The number of patients in each study is small but the evidence is compelling enough to recommend FDG PET imaging in the routine care of these patients.

  19. Pet in Clinical oncology

    International Nuclear Information System (INIS)

    Hunsche, A.; Grossman, G.; Santana, M.; Santana, C.; Halkar, R.; Garcia, E.

    2003-01-01

    The utility of the PET (positron emission tomography in clinical oncology has been recognized for more than two decades, locating it as a sensible technique for the diagnosis and the prognosis stratification of the oncology patients. The sensitivity and specificity of the PET in comparation to other image studies have demonstrated to be greater. For some years, there was a restriction of PET because of the high cost of the equipment and the cyclotrons. Nevertheless, the relation of cost/benefits is considered as a priority as this technique offers important clinical information. In this article the results observed when using it in diverse types of cancer, as well as the effectiveness shown in the pre-operating evaluation, the evaluation of residual disease, diagnosis of recurrences, pursuit and prognosis stratification of the patients with cancer. (The author)

  20. Metabolic imaging using PET

    International Nuclear Information System (INIS)

    Kudo, Takashi

    2007-01-01

    There is growing evidence that myocardial metabolism plays a key role not only in ischaemic heart disease but also in a variety of diseases which involve myocardium globally, such as heart failure and diabetes mellitus. Understanding myocardial metabolism in such diseases helps to elucidate the pathophysiology and assists in making therapeutic decisions. As well as providing information on regional changes, PET can deliver quantitative information about both regional and global changes in metabolism. This capability of quantitative measurement is one of the major advantages of PET along with physiological positron tracers, especially relevant in evaluating diseases which involve the whole myocardium. This review discusses major PET tracers for metabolic imaging and their clinical applications and contributions to research regarding ischaemic heart disease and other diseases such as heart failure and diabetic heart disease. Future applications of positron metabolic tracers for the detection of vulnerable plaque are also highlighted briefly. (orig.)

  1. The journey: from X-rays to PET-MRI

    International Nuclear Information System (INIS)

    Sheikh, Tariq Hussain

    2010-01-01

    Full text: Medical imaging has undergone remarkable evolution over the past century. Since the discovery of the X-rays by (Wilhelm Conrad Roentgen), static emission tomography (Hal Anger) computed tomography (Godfrey Hounsfield and Alan Cormack), and magnetic resonance imaging (Paul Lauterbur and Peter Mansfield) there have been many other important discoveries and technical developments that have culminated in our current sophisticated multi-modality imaging systems. Nobel Prizes have been given for the discoveries of radioactivity (Marie Curie, Pierre Curie, and Henri Becquerel in 1903) and the positron (Carl Anderson in 1936) and for technical developments such as the radiotracer concept (George De Hevesy in 1943). Positron emission detection systems have developed since their first use in the 1950s to the high-resolution, high-sensitivity tomographic devices that we have today. In keeping pace with these milestones in the evolution of medical imaging, positron emission tomography (PET), and more recently integrated positron emission tomography-computed tomography (PET-CT), have now emerged not only as important research tools but also as significant diagnostic imaging systems in clinical medicine. The use of multi-modality imaging systems and 'smart' specific imaging agents will achieve the key task of accurate diagnosis, treatment evaluation, surveillance, and prognosis in individual patients. PET-CT instrumentation has continued to evolve rapidly, especially over the last decade A PET scanner is combined with a CT scanner into a single machine. The PET and CT components are mounted on the same aluminium support with the CT on the front and PET at the back. Metabolic information is obtained from the PET scanner (emission of annihilation photons) and anatomic information is obtained from the CT scan (transmission of X-Rays). In addition, the CT scan can be used to provide information needed for attenuation correction. The current generation of PET-CT scanners

  2. Synthesis of carbon-11 labeled 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinolinium derivatives as new potential PET SK{sub Ca} channel imaging agents

    Energy Technology Data Exchange (ETDEWEB)

    Gao Mingzhang; Wang Min [Department of Radiology, Indiana University School of Medicine, 1345 West 16th Street, L-3 Room 202, Indianapolis, IN 46202 (United States); Zheng Qihuang [Department of Radiology, Indiana University School of Medicine, 1345 West 16th Street, L-3 Room 202, Indianapolis, IN 46202 (United States)], E-mail: qzheng@iupui.edu

    2008-02-15

    Small conductance Ca{sup 2+}-activated K{sup +} (SK{sub Ca}) channels play an important role in many functions such as neuronal communication and behavioral plasticity, secretion, and cell proliferation. SK{sub Ca} channel modulation is associated with various brain, heart, and cancer diseases. N-methyl-laudanosine and its structurally related derivatives, substituted 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinoliniums, are reversible and selective SK{sub Ca} channel blockers. Carbon-11 labeled N-methyl-laudanosine and its tetrahydroisoquinolinium derivatives may serve as new probes for positron emission tomography (PET) to image SK{sub Ca} channels in the brain, heart, and cancer. The key intermediates, substituted isoquinolines (3a-c), were synthesized using a modification of the Pomeranz-Fritsch procedure. The precursors, substituted 1-(3,4-dimethoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolines (8a-c), and their corresponding reference standards, substituted 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinoliniums (9a-c), were synthesized from compounds 3a-c with 3,4-dimethoxybenzyl chloride (2) in multiple steps with moderate to excellent chemical yields. The precursor 6,7-dimethoxy-1-(3,4-dimethoxybenzyl)-2-methyl-1,2,3, 4-tetrahydroisoquinoline (10) was commercially available, and the methylation of compound 10 with methyl iodide provided N-methyl-laudanosine (11). The target quaternary ammonium tracers, carbon-11 labeled 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinoliniums ([{sup 11}C]9a-c and [{sup 11}C]11), were prepared by N-[{sup 11}C]methylation of the tertiary amine precursors (8a-c and 10) with [{sup 11}C]methyl triflate and isolated by a simplified solid-phase extraction (SPE) purification using a SiO{sub 2} or cation-exchange CM Sep-Pak cartridge in 40-65% radiochemical yields.

  3. A Hockey Night in Canada: An Imagined Conversation between Theorists

    Science.gov (United States)

    Fogel, Curtis

    2010-01-01

    In this paper, various methodological issues surrounding the sociological study of sport are explored. Through an imagined dialogue between two graduate students at a hockey game, this work brings together three divergent approaches to social enquiry: Positivist Grounded Theory, Constructivist Grounded Theory, and Actor-Network Theory. This paper…

  4. Geography and Creativity: Developing Joyful and Imaginative Learners

    Science.gov (United States)

    Scoffham, Stephen

    2013-01-01

    Creativity is a complex and contested notion but is now widely recognised as a feature of learning across the curriculum. This article explores how primary geography teaching can be enriched by creative practice. It goes beyond simply suggesting imaginative ways to devise geography lessons, to outline a pedagogy which places children at the heart…

  5. Activating the Imagination inside the World Language Classroom

    Science.gov (United States)

    Mitchell, Claire

    2015-01-01

    Imagination, creation, and innovation are three powerful words that present many possibilities in the world language classroom. When learners can see themselves as language users, they take ownership of their learning experience and become more invested in and engaged with the topic being studied. This heightened sense of investment in turn leads…

  6. 'To Think Representatively': Arendt on Judgment and the Imagination

    African Journals Online (AJOL)

    ... the standpoint of the spectator, I go on to examine their most distinctive features, in particular, the link between judgment, the imagination, and the ability to think 'representatively'. I also examine the philosophical sources of Arendt's theory of judgment, namely, Kant's theory of aesthetic judgment and its criteria of validity.

  7. Activation of Imaginal Information on True and False Memories

    Science.gov (United States)

    Chang, Sau Hou; Pierce, Benton H.

    2009-01-01

    The present study examined the activation of imaginal information on true and false memories. Participants studied a series of concrete objects in pictures or words. The imagery group (n = 96) was instructed to form images and the control group (n = 96) was not instructed to do so. Both groups were then given a standard recognition memory test and…

  8. Test of Creative Imagination: Validity and Reliability Study

    Science.gov (United States)

    Gundogan, Aysun; Ari, Meziyet; Gonen, Mubeccel

    2013-01-01

    The purpose of this study was to investigate validity and reliability of the test of creative imagination. This study was conducted with the participation of 1000 children, aged between 9-14 and were studying in six primary schools in the city center of Denizli Province, chosen by cluster ratio sampling. In the study, it was revealed that the…

  9. Human Rights Education: Imaginative Possibilities for Creating Change

    Science.gov (United States)

    Bajaj, Monisha

    2015-01-01

    Background/Context: Human rights education has proliferated in the past four decades and can be found in policy discussions, textbook reforms, and grassroots initiatives across the globe. This article specifically explores the role of creativity and imagination in human rights education (HRE) by focusing on a case study of one non-governmental…

  10. Runaway globalization and the cultural imagination of dependency ...

    African Journals Online (AJOL)

    justify racial inequality which works to the political and economic advantage of the West. Globalisation and globalism by their nature and design therefore work hand in hand to ensure a hegemonic consciousness among Africans such that even their responses to globalisation is imagined and mediated from the pedestal of ...

  11. Globalisation, the Research Imagination and Deparochialising the Study of Education

    Science.gov (United States)

    Lingard, Bob

    2006-01-01

    This paper works in dialogue with Arjun Appadurai's paper, "Grassroots globalization and the research imagination" in an attempt to outline some necessary changes in researching education in the multiple contexts of globalisation. The paper provides two narratives as part of this project, which Appadurai calls the…

  12. Film showing - Higgs: into the heart of imagination

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    On 29 April at 7pm Dutch filmmakers, Hannie van den Bergh and Jan van den Berg, will introduce their directorial debut, Higgs: into the heart of imagination in CERN’s Main Auditorium.   This documentary is about the curiousity, passion and imaginative powers of science. Featuring physicists working at CERN, in particular in ATLAS, and filmed over four years, the film-makers have created a cinematic journey into the heart of imagination. They follow Stan Bentvelsen, head of the Dutch research group at CERN, and watch as he prepares his team for the start of the LHC, as well as the scientific competition to find the elusive Higgs particle. The film also features Peter Higgs as he discusses his work from 1964. The directors have created theatre productions and other multimedia projects under the title The Imagination of Invisible Dimensions, which allow for adventurous dialogues between art and science. All are welcome to attend this showing and afterwards there will be a short question...

  13. Engaging Social Imagination: The Developmental Work of Wordless Book Reading

    Science.gov (United States)

    Lysaker, Judith T.; Miller, Angela

    2013-01-01

    The reading process and reading development have been addressed by researchers for decades. As a result we know much about what reading is and how it happens. However, less is known about how reading influences other aspects of children's development, specifically the development of social imagination. To address this, we examined the narrative…

  14. Just Research in Contentious Times: Widening the Methodological Imagination

    Science.gov (United States)

    Fine, Michelle

    2017-01-01

    In this intensely powerful and personal new text, Michelle Fine widens the methodological imagination for students, educators, scholars, and researchers interested in crafting research with communities. Fine shares her struggles over the course of 30 years to translate research into policy and practice that can enhance the human condition and…

  15. Imagining and Feeling: Experiential Learning in Mass Communication Instruction.

    Science.gov (United States)

    Parcells, Frank E.

    Defining the media experience as the media and social interaction involved in any person's viewing of television and the consequences of that viewing for oneself and others, this paper examines how phenomenology and psychodrama--methods of experiential learning focusing on the feeling and imagining functions of communication--can be used to teach…

  16. Imagining Another Context during Encoding Offsets Context-Dependent Forgetting

    Science.gov (United States)

    Masicampo, E. J.; Sahakyan, Lili

    2014-01-01

    We tested whether imagining another context during encoding would offset context-dependent forgetting. All participants studied a list of words in Context A. Participants who remained in Context A during the test recalled more than participants who were tested in another context (Context B), demonstrating the standard context-dependent forgetting…

  17. Imagine That!: Science Fiction as a Learning Motivation

    Science.gov (United States)

    Ontell, Val

    2003-01-01

    This article, based on a presentation made by the author at the 2003 California Library Association conference, provides examples of how librarians and teachers can use Science Fiction to provide catalysts for discussion in a variety of subjects; teach students how to question intelligently; and stimulate their imaginations, thus motivating them…

  18. Democratising the Research Imagination: Globalising Knowledge about HIV/AIDS

    Science.gov (United States)

    Epstein, Debbie; Boden, Rebecca

    2006-01-01

    This paper problematises globalisation and the democratisation of the research imagination, highlighting the potentials for harm and good. We do so, first, by exploring two philosophical/epistemological issues: the definition of "knowledge" and the role of "research" in knowledge creation. The paper then considers some of…

  19. Managing the Research Imagination? Globalisation and Research in Higher Education

    Science.gov (United States)

    Boden, Rebecca; Epstein, Debbie

    2006-01-01

    This paper argues that, during the late twentieth and early twenty-first centuries, universities have been captured by neo-liberal regimes of truth. We suggest that this may inhibit the "research imagination" within universities and, consequently, their role in the democratisation of knowledge. We consider the role of capital in the…

  20. Imagining the Music: Methods for Assessing Musical Imagery Ability

    Science.gov (United States)

    Clark, Terry; Williamon, Aaron

    2012-01-01

    Timing profiles of live and imagined performances were compared with the aim of creating a context-specific measure of musicians' imagery ability. Thirty-two advanced musicians completed imagery use and vividness surveys, and then gave two live and two mental performances of a two-minute musical excerpt, tapping along with the beat of the mental…

  1. Television and the Developing Imagination of the Child.

    Science.gov (United States)

    Singer, Dorothy G.; Singer, Jerome L.

    1981-01-01

    The literature review discusses studies which have been conducted to determine whether television enriches a child's imagination or leads to distortions of reality, and whether adult mediation during a child's television viewing or immediately after can evoke constructive changes or stimulate make-believe play. Thirty-six references are cited.…

  2. Imagination, Playfulness, and Creativity in Children's Play with Different Toys

    Science.gov (United States)

    Mo????ller, Signe?? Juhl?

    2015-01-01

    Based on a four-month experimental study of preschool children's play with creative-construction and social-fantasy toys, the author examines the in?uence of both types of toys on the play of preschool children. Her comparative analysis considers the impact of transformative play on the development of imagination during play activities and…

  3. An Imagination Effect in Learning from Scientific Text

    Science.gov (United States)

    Leopold, Claudia; Mayer, Richard E.

    2015-01-01

    Asking students to imagine the spatial arrangement of the elements in a scientific text constitutes a learning strategy intended to foster deep processing of the instructional material. Two experiments investigated the effects of mental imagery prompts on learning from scientific text. Students read a computer-based text on the human respiratory…

  4. Omission, Suggestion, Completion : Film and the Imagination of the Spectator

    NARCIS (Netherlands)

    Hanich, Julian

    2018-01-01

    This article counters the widespread assumption that film is exclusively a medium of showing, presentation or appearing by emphasizing the importance of the viewer’s act of imagination. At the center of attention is the aesthetic principle of omission, suggestion, and completion in film – in other

  5. The role of imagination in experiencing natural environments

    Science.gov (United States)

    Herbert. Schroeder

    2010-01-01

    The experience of natural environments and places is multifaceted, involving psychological functions such as perception, cognition, memory, emotion, and imagination. Environmental perception and cognition were key topics in early research in environmental psychology. More recently, attention has also been directed to affective dimensions of environmental experience,...

  6. Exile, exilic consciousness and the poetic imagination in Tanure ...

    African Journals Online (AJOL)

    As a thematic trajectory, exile constitutes a visible presence in the Nigerian poetic afflatus and imagination. This is sometimes not adequately or sufficiently acknowledged. Increasingly, however, exile and exilic consciousness have continued to occupy a contested and contestable site in literature especially Nigerian poetry.

  7. Unwritten: (Re)Imagining FE as Social Purpose Education

    Science.gov (United States)

    Mycroft, Lou

    2018-01-01

    Drawing on stories from ten years of social purpose teacher education in the UK, this paper assumes that the future of further education is still unwritten. It illustrates complex and workable ideas via a theorised sketch of the fictional Bee Learning Programme, an imagined education setting of the future. The narrative that follows is designed to…

  8. Effects of Imagined Interactions and Rehearsal on Speaking Performance

    Science.gov (United States)

    Choi, Charles W.; Honeycutt, James M.; Bodie, Graham D.

    2015-01-01

    Imagined interactions (IIs) constitute a type of social cognition that can reduce fear of communication. Through the mental preparation enabled by IIs, an individual can reduce disfluencies and mitigate the anxiety that arises from a speech. Study 1 indicated that rehearsal influences the reduction of silent pauses but not vocalized pauses. In…

  9. Our Language: (Re)Imagining Communities in Ukrainian Language Classrooms

    Science.gov (United States)

    Friedman, Debra A.

    2016-01-01

    Drawing upon video recordings from two fifth-grade Ukrainian classrooms and interviews with children four years later, this paper examines these classrooms as sites for socializing learners into an "imagined community" of Ukrainian speakers, the extent to which children took up identities as members of this community, and the potential…

  10. Imagining the Political : Young Women, Participation and the ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Imagining the Political : Young Women, Participation and the Crafting of the Political in Egypt. IDRC's Women's Rights and Citizenship (WRC) program initiative is supporting a body of comparative research on whether and how democracy and governance institutions are responding to women's rights and gender equality.

  11. Musical Imagination: Perception and Production, Beauty and Creativity

    Science.gov (United States)

    Hargreaves, David J.

    2012-01-01

    In our recently-published book "Musical Imaginations" (Hargreaves, Miell, & MacDonald, 2012), I suggest that the creative aspects of music "listening" have been neglected, and that putting these at the centre of musical creativity (which is usually seen as being manifested in the activities of composition, improvisation and performance) can lead…

  12. Manual for Scoring the Test of Directed Imagination.

    Science.gov (United States)

    Veldman, Donald J.; And Others

    A scoring manual for the Directed Imagination Test, a projective technique wherein the subject is instructed to write four fictional stories (four minutes are allowed for each) about teachers and their experiences, is presented. The manual provides detailed instructions for rating each story by fifteen dimensions relevant to teacher education…

  13. Literature and Truth : Imaginative Writing as a Medium for Ideas

    NARCIS (Netherlands)

    Lansdown, Richard

    2017-01-01

    In Literature and Truth Richard Lansdown continues a discussion concerning the truth-bearing status of imaginative literature that pre-dates Plato. The book opens with a general survey of contemporary approaches in philosophical aesthetics, and a discussion of the contribution to the question made

  14. Imagination et temporalisation chez Kant, Husserl et Richir

    Czech Academy of Sciences Publication Activity Database

    Fazakas, Istvan

    2016-01-01

    Roč. 3, č. 2 (2016), s. 502-521 ISSN 2067-3655 R&D Projects: GA ČR(CZ) GJ16-00994Y Institutional support: RVO:67985955 Keywords : image * imagination * phantasia * schematism * temporalization * presence * present * weilen Subject RIV: AA - Philosophy ; Religion http://www.metajournal.org/article_details.php?id=278

  15. Classification of Real and Imagined Sounds in Early Visual Cortex

    Directory of Open Access Journals (Sweden)

    Petra Vetter

    2011-10-01

    Full Text Available Early visual cortex has been thought to be mainly involved in the detection of low-level visual features. Here we show that complex natural sounds can be decoded from early visual cortex activity, in the absence of visual stimulation and both when sounds are actually displayed and when they are merely imagined. Blindfolded subjects listened to three complex natural sounds (bird singing, people talking, traffic noise; Exp. 1 or received word cues (“forest”, “people”, “traffic”; Exp 2 to imagine the associated scene. fMRI BOLD activation patterns from retinotopically defined early visual areas were fed into a multivariate pattern classification algorithm (a linear support vector machine. Actual sounds were discriminated above chance in V2 and V3 and imagined sounds were decoded in V1. Also cross-classification, ie, training the classifier to real sounds and testing it to imagined sounds and vice versa, was successful. Two further experiments showed that an orthogonal working memory task does not interfere with sound classification in early visual cortex (Exp. 3, however, an orthogonal visuo-spatial imagery task does (Exp. 4. These results demonstrate that early visual cortex activity contains content-specific information from hearing and from imagery, challenging the view of a strict modality-specific function of early visual cortex.

  16. Business mereology: imaginative definitions of insourcing and outsourcing transformations

    NARCIS (Netherlands)

    Bergstra, J.A.; van Vlijmen, S.F.M.

    2010-01-01

    Outsourcing, the passing on of tasks by organizations to other organizations, often including the personnel and means to perform these tasks, has become an important IT-business strategy over the past decades. We investigate imaginative definitions for outsourcing relations and outsourcing

  17. Stories and Science: Stirring Children's Imagination

    Science.gov (United States)

    Seeley, Claire; Gallagher, Sarah

    2014-01-01

    Stories are a place where magical things happen, where ideas are challenged, where the imagination runs free and questions are asked. They are a safe place, where the reader can walk about with new identities, try new ideas, process life's ups and downs and make new meanings. This makes stories the perfect place for creative learning. In this…

  18. Go West: Imagining the Oregon Trail. [Lesson Plan].

    Science.gov (United States)

    National Endowment for the Humanities (NFAH), Washington, DC.

    In this lesson plan, students in grades 3-5 compare imagined travel experiences of their own with the actual experiences of 19th-century pioneers on the Oregon Trail. After the 4 lessons students will have: (1) learned about the pioneer experience on the Oregon Trail; (2) compared and contrasted modern-day travel experiences with those of the 19th…

  19. The war in children's imagination: What psychopedagogical routes?

    Directory of Open Access Journals (Sweden)

    Anna Maria Disanto

    2011-12-01

    Full Text Available The aim of the pilot study presented below is to investigate the imagination of children of war. Starting from a project of peace education, has been developed a questionnaire containing some items about war and peace’s fuction. 270 children were interviewed. The first results are discussed below.

  20. Olfactory Imagination and Odor Processing: Three Same-Different Experiments

    NARCIS (Netherlands)

    Koster, E.P.; Stelt, van der O.; Nixdorf, R.R.; Linschoten, M.R.I.; Mojet, J.; Wijk, de R.A.

    2014-01-01

    Do people who claim to have olfactory imagination process odors more efficiently? In three same–different experiments, using all possible combinations of odors and odor names as primes and targets, selected high imagers (n¿=¿12) were faster (±230 ms; P¿

  1. Imagined Voices : a poetics of Music-Text-Film

    NARCIS (Netherlands)

    Kyriakides, Y.

    2017-01-01

    Imagined Voices deals with a form of composition, music with on-screen text, in which the dynamic between sound, words and visuals is explored. The research explores the ideas around these 'music-text-films', and attempts to explain how meaning is constructed in the interplay between the different

  2. Student peer reviewers' views on teaching innovations and imaginative learning.

    Science.gov (United States)

    Chan, Zenobia C Y

    2016-04-01

    Various teaching innovations have been proven effective in promoting students' critical thinking, creativity, problem solving and active learning. However, little attention has been paid to the possibility of including students as peer reviewers to evaluate these innovations in light of imaginative learning. This study explored the perspective of senior students who played the role of the student peer reviewer on three teaching innovations, namely writing poetry, composing songs and creating role-plays in problem-based learning (PBL), specifically in relation to imaginative learning. A focus group interview. Ten senior nursing students who had experienced the conventional PBL approach but not the mentioned teaching innovations were invited to participate in reviewing a video recording of a PBL class using the above teaching innovations with a total of 18 junior year students. Five themes were identified using content analysis: (i) motivation to learn, (ii) increased empathy, (iii) information retention, (iv) development of critical thinking and creativity, and (v) drawbacks of teaching innovations. It is suggested that student peer reviewers should be considered, as they can bring an outsider-learner's views on understanding the impacts of teaching innovations on imaginative learning. A call should be made to invite student peer reviewers on teaching and learning approaches, and more effort should be devoted to promoting an understanding of how imaginative learning can be achieved via teaching innovations. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. Re-Imagining the Land, North Sutherland, Scotland

    Science.gov (United States)

    Mackenzie, A. F. D.

    2004-01-01

    This paper focuses on contemporary re-imaginings of the land in North Sutherland that counter global, modernist discourse. One narrative concerns the reinvention of the past; the other concerns the reconstruction of the present. Through both, people create what Edward Said (Culture and Imperialism. Alfred A. Knopf, New York, 1994) calls a…

  4. Faith and the Literary Imagination: The Educational Challenge

    Science.gov (United States)

    Williams, Kevin

    2013-01-01

    Divided into four parts, the article explores the relationship between literature and faith. The first part examines the connection between literature and the pursuit of truth and the second shows that literature can offer a challenging encounter with different beliefs. Part three examines some examples of the imagination at work in illuminating…

  5. Inverted Commons: Africa’s Nature in the Global Imagination.

    NARCIS (Netherlands)

    B.E. Büscher (Bram)

    2012-01-01

    textabstractNature in Africa has long occupied a special place in the global imagination: the prevailing images associated with the continent are of a “wild Eden,” of rugged, “pristine” landscapes, and of some of the world’s most charismatic “megafauna” (elephants, gorillas, rhinos, etc.) (Adams and

  6. Novel PET sensors

    International Nuclear Information System (INIS)

    Cooper, C.R.

    2001-03-01

    This thesis describes the design, synthesis and evaluation of novel molecular sensors that utilize the phenomena of Photoinduced Electron Transfer (PET). PET design can be incorporated into molecules to allow them to selectively bind certain guest molecules. PET works by the modulation of electron potentials within a molecule. Binding events between a host and guest can, if designed suitably, change these potentials enough to cause a transfer of electronic charge within the molecular sensor. This event can be accurately and sensitively monitored by the use of ultra violet or fluorescence spectroscopy. A sensor molecule can be constructed by matching the guest to a suitable receptor site and incorporating this into a molecule containing a fluorophore with the correct electron potential characteristics. By using existing synthetic routes as well as exploiting new pathways these sensor molecules C n be constructed to contain a fluorophore separated from a guest receptor(s) by suitable spacers units. When put together these facets go to creating molecules that by design are sensitive and selective for certain guest molecules or functional groups. This methodology allows the synthetic chemist to rationally design and synthesise PET sensors, tailored to the needs of the guest. In this thesis the synthesis and evaluation of a novel PET sensors for D-glucosamine, disaccharides and fluoride is presented. It is believed that the novel sensors using the PET phenomenon presented in this thesis are a worthwhile extension of previous works undertaken by other groups around the world and shows new pathways to increasingly complex and sophisticated sensor molecular design. (author)

  7. Fusion of PET and MRI for Hybrid Imaging

    Science.gov (United States)

    Cho, Zang-Hee; Son, Young-Don; Kim, Young-Bo; Yoo, Seung-Schik

    Recently, the development of the fusion PET-MRI system has been actively studied to meet the increasing demand for integrated molecular and anatomical imaging. MRI can provide detailed anatomical information on the brain, such as the locations of gray and white matter, blood vessels, axonal tracts with high resolution, while PET can measure molecular and genetic information, such as glucose metabolism, neurotransmitter-neuroreceptor binding and affinity, protein-protein interactions, and gene trafficking among biological tissues. State-of-the-art MRI systems, such as the 7.0 T whole-body MRI, now can visualize super-fine structures including neuronal bundles in the pons, fine blood vessels (such as lenticulostriate arteries) without invasive contrast agents, in vivo hippocampal substructures, and substantia nigra with excellent image contrast. High-resolution PET, known as High-Resolution Research Tomograph (HRRT), is a brain-dedicated system capable of imaging minute changes of chemicals, such as neurotransmitters and -receptors, with high spatial resolution and sensitivity. The synergistic power of the two, i.e., ultra high-resolution anatomical information offered by a 7.0 T MRI system combined with the high-sensitivity molecular information offered by HRRT-PET, will significantly elevate the level of our current understanding of the human brain, one of the most delicate, complex, and mysterious biological organs. This chapter introduces MRI, PET, and PET-MRI fusion system, and its algorithms are discussed in detail.

  8. PET and endocrine tumors

    International Nuclear Information System (INIS)

    Rigo, P.; Belhocine, T.; Hustinx, R.; Foidart-Willems, J.

    2000-01-01

    The authors review the main indications of PET examination, and specifically of 18 FDG, in the assessment of endocrine tumors: of the thyroid, of the parathyroid, of the adrenal and of the pituitary glands. Neuroendocrine tumors, gastro-entero-pancreatic or carcinoid tumors are also under the scope. Usually, the most differentiated tumors show only poor uptake of the FDG as they have a weak metabolic and proliferative activity. In the assessment of endocrine tumors, FDG-PET should be used only after most specific nuclear examinations been performed. (author)

  9. Imaginative ethics--bringing ethical praxis into sharper relief.

    Science.gov (United States)

    Hansson, Mats G

    2002-01-01

    The empirical basis for this article is three years of experience with ethical rounds at Uppsala University Hospital. Three standard approaches of ethical reasoning are examined as potential explanations of what actually occurs during the ethical rounds. For reasons given, these are not found to be satisfying explanations. An approach called "imaginative ethics", is suggested as a more satisfactory account of this kind of ethical reasoning. The participants in the ethical rounds seem to draw on a kind of moral competence based on personal life experience and professional competence and experience. By listening to other perspectives and other experiences related to one particular patient story, the participants imagine alternative horizons of moral experience and explore a multitude of values related to clinical practice that might be at stake. In his systematic treatment of aesthetics in the Critique of Judgement, Kant made use of an operation of thought that, if applied to ethics, will enable us to be more sensitive to the particulars of each moral situation. Based on this reading of Kant, an account of imaginative ethics is developed in order to bring the ethical praxis of doctors and nurses into sharper relief. The Hebraic and the Hellenic traditions of imagination are used in order to illuminate some of the experiences of ethical rounds. In conclusion, it is argued that imaginative ethics and principle-based ethics should be seen as complementary in order to endow a moral discourse with ethical authority. Kantian ethics will do the job if it is remembered that Kant suggested only a modest, negative role of principle-based deliberation.

  10. Comparison of first pass bolus AIFs extracted from sequential {sup 18}F-FDG PET and DSC-MRI of mice

    Energy Technology Data Exchange (ETDEWEB)

    Evans, Eleanor, E-mail: ee244@cam.ac.uk [Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0QQ (United Kingdom); Sawiak, Stephen J. [Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0QQ (United Kingdom); Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB (United Kingdom); Ward, Alexander O.; Buonincontri, Guido; Hawkes, Robert C.; Adrian Carpenter, T. [Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0QQ (United Kingdom)

    2014-01-11

    Accurate kinetic modelling of in vivo physiological function using positron emission tomography (PET) requires determination of the tracer time–activity curve in plasma, known as the arterial input function (AIF). The AIF is usually determined by invasive blood sampling methods, which are prohibitive in murine studies due to low total blood volumes. Extracting AIFs from PET images is also challenging due to large partial volume effects (PVE). We hypothesise that in combined PET with magnetic resonance imaging (PET/MR), a co-injected bolus of MR contrast agent and PET ligand can be tracked using fast MR acquisitions. This protocol would allow extraction of a MR AIF from MR contrast agent concentration–time curves, at higher spatial and temporal resolution than an image-derived PET AIF. A conversion factor could then be applied to the MR AIF for use in PET kinetic analysis. This work has compared AIFs obtained from sequential DSC-MRI and PET with separate injections of gadolinium contrast agent and {sup 18}F-FDG respectively to ascertain the technique′s validity. An automated voxel selection algorithm was employed to improve MR AIF reproducibility. We found that MR and PET AIFs displayed similar character in the first pass, confirmed by gamma variate fits (p<0.02). MR AIFs displayed reduced PVE compared to PET AIFs, indicating their potential use in PET/MR studies.

  11. PET/MR in oncology

    DEFF Research Database (Denmark)

    Balyasnikova, Svetlana; Löfgren, Johan; de Nijs, Robin

    2012-01-01

    of the challenges inherent in this new technology, but focus on potential applications for simultaneous PET/MR in the field of oncology. Methods and tracers for use with the PET technology will be familiar to most readers of this journal; thus this paper aims to provide a short and basic introduction to a number...... be applied together with PET increasing the amount of information about the tissues of interest. The potential clinical benefit of applying PET/MR in staging, radiotherapy planning and treatment evaluation in oncology, as well as the research perspectives for the use of PET/MR in the development of new...

  12. Simultaneous PET and MR imaging

    International Nuclear Information System (INIS)

    Yiping Shao; Cherry, Simon R.; Meadors, Ken; Siegel, Stefan; Silverman, Robert W.; Farahani, Keyvan; Marsden, Paul K.

    1997-01-01

    We have developed a prototype PET detector which is compatible with a clinical MRI system to provide simultaneous PET and MR imaging. This single-slice PET system consists of 48 2x2x10mm 3 LSO crystals in a 38 mm diameter ring configuration that can be placed inside the receiver coil of the MRI system, coupled to three multi-channel photomultipliers housed outside the main magnetic field via 4 m long and 2 mm diameter optical fibres. The PET system exhibits 2 mm spatial resolution, 41% energy resolution at 511 keV and 20 ns timing resolution. Simultaneous PET and MR phantom images were successfully acquired. (author)

  13. Examination of Athletes' Anxiety, Motivation, Imagination Value in Competitions with Different Severity Level

    Science.gov (United States)

    Sallayici, Mustafa; Eroglu Kolayis, Ipek; Kesilmis, Inci; Kesilmis, Mehmet Melih

    2018-01-01

    The objective of this study was to examine athletes' anxiety, motivation, and imagination value in competitions with different severity level. The research was conducted on swimming athlete in elite level 18 female and 19 male totally 37. To measure the level of imagination, imagine inventory in sports and to measure trait anxiety levels STAI were…

  14. Active-imaginal exposure: examination of a new behavioral treatment for cynophobia (dog phobia)

    NARCIS (Netherlands)

    Rentz, T.O.; Powers, M.B.; Smits, J.A.J.; Cougle, J.R.; Telch, M.J.

    2003-01-01

    The aims of this study were to investigate exposure-based treatments for cynophobia (dog phobia) and to test a newly developed hybrid imaginal exposure treatment that we have named active imaginal exposure. The treatment introduces an in vivo coping component to imaginal exposure whereby the patient

  15. The New ICE-Age: Frozen and Thawing Perceptions of Imagination

    Science.gov (United States)

    Hatt, Blaine E.

    2018-01-01

    The article examines the importance of imagination in adult-child relationships in 21st-century experiential learning, where ICE is an acronym for Imagination Creativity Education. It explores, through hermeneutic phenomenology, the impact of imagination in the life-experiences of three school-aged children through the wonder of toying, through…

  16. Impact of molecular imaging with PET on healthcare worldwide

    International Nuclear Information System (INIS)

    Alavi, Abbas

    2009-01-01

    Full text: FDG-PET imaging has substantially improved healthcare throughout the world. This technique has been applied to patients with some of the most serious diseases, including cancer, central nervous system disorders, cardiovascular disease and infections including infected prostheses. There is also enormous potential for further improvement in patient management using this technique, for example, in the detection of atherosclerosis and clots, and assessment of muscle function. Studies using FDG-PET methodology have led to the development of many novel radiotracers that have been designed to explore new diagnostic and therapeutic domains. We therefore expect that molecular imaging with PET will play an increasingly central role in research and in the optimal management of patients with many disorders. This will include diagnosing pathological processes at the molecular level and individualizing treatment for these patients. By utilizing PET and the appropriately labeled pharmaceuticals, one will be able to select the most suitable therapeutic drugs for a particular disease, instead of administering drugs to patients without a good idea of the chance of efficacy. Likewise, PET will increasingly play a major role in drug development by demonstrating the degree to which the intended pharmaceutical targets the diseased tissues in animal models and in human beings. PET will also assist in determining the rate of metabolism of the administered drugs by different tissues. PET imaging will also allow accurate staging of cancer and other serious diseases and will be adopted as the most accurate technique for monitoring response to treatment and detecting recurrence. The role of CT and/or MRI as independent modalities in medicine will decrease as the efficacy of PET is realized by scientists and clinicians alike. In particular, the use of contrast agents such as iodinated compounds and gadolinium based agents will be minimized. Similarly, imaging with single gamma

  17. PET and PET/CT in malignant melanoma; PET y PET/CT en melanoma maligno

    Energy Technology Data Exchange (ETDEWEB)

    Garcia O, J R [Nuclear Medicine and Molecular Imaging PET/CT, Centro Medico ABC, Mexico D.F. (Mexico)

    2007-07-01

    The advantages that it has the PET/CT are: 1. It diminishes mainly positive false lesions. It identifies physiologic accumulate places. 2. It diminishes in smaller grade false negative. Small injuries. Injuries with low grade concentration. Injure on intense activity areas. 3. Precise anatomical localization of accumulate places. 4. Reduction of the acquisition time. (Author)

  18. Combined PET/MRI

    DEFF Research Database (Denmark)

    Bailey, D. L.; Pichler, B. J.; Gückel, B.

    2015-01-01

    This paper summarises key themes and discussions from the 4th international workshop dedicated to the advancement of the technical, scientific and clinical applications of combined positron emission tomography (PET)/magnetic resonance imaging (MRI) systems that was held in Tübingen, Germany, from...

  19. I Love Petting Zoos!

    Centers for Disease Control (CDC) Podcasts

    2010-03-23

    This Kidtastics podcast helps children learn about how to stay safe and healthy when visiting petting zoos and other animal exhibits.  Created: 3/23/2010 by Centers for Disease Control and Prevention (CDC).   Date Released: 3/23/2010.

  20. PET's indsats under lup

    DEFF Research Database (Denmark)

    Hansen, Peer Henrik

    2006-01-01

    En undersøgelseskommission nedsat i 1999. Fem medlemmer skal undersøge PET's efterretningsvirksomhed i forhold til politiske partier, faglige konflikter og politisk ideologiske bevægelser i Danmark under den kolde krig. Kommissionens rapport forventes færdig næste år. Udgivelsesdato: 2. juli 2006...

  1. Choosing a Pet

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    THE capital boasts countless markets of all kinds,but some of its insect,bird and pet markets immortalize Beijing culture and folkloric traditions.Don’t miss it! The Huasheng Tianqiao Market,south of the famous Panjiayuan Antique Market, was moved a few years ago and rebuilt in the

  2. PET CT and lymphomas

    International Nuclear Information System (INIS)

    Castro, R.

    2012-01-01

    This presentation is about Tc and lymphomas. Classification and clinical cases of various cancer such as gastro duodenal or ulcer, mama, medullary, lymph and neck, leukemia, nodular sclerosis. Metabolic information, anatomical nature of lymphoma and its clinical presentation determine the extent that PET should be used in the patient.

  3. PET imaging of the autonomic nervous system

    International Nuclear Information System (INIS)

    THACKERAY, James T.; BENGEL, Frank M.

    2016-01-01

    The autonomic nervous system is the primary extrinsic control of heart rate and contractility, and is subject to adaptive and maladaptive changes in cardiovascular disease. Consequently, noninvasive assessment of neuronal activity and function is an attractive target for molecular imaging. A myriad of targeted radiotracers have been developed over the last 25 years for imaging various components of the sympathetic and parasympathetic signal cascades. While routine clinical use remains somewhat limited, a number of larger scale studies in recent years have supplied momentum to molecular imaging of autonomic signaling. Specifically, the findings of the ADMIRE HF trial directly led to United States Food and Drug Administration approval of 123I-metaiodobenzylguanidine (MIBG) for Single Photon Emission Computed Tomography (SPECT) assessment of sympathetic neuronal innervation, and comparable results have been reported using the analogous PET agent 11C-meta-hydroxyephedrine (HED). Due to the inherent capacity for dynamic quantification and higher spatial resolution, regional analysis may be better served by PET. In addition, preliminary clinical and extensive preclinical experience has provided a broad foundation of cardiovascular applications for PET imaging of the autonomic nervous system. Recent years have witnessed the growth of novel quantification techniques, expansion of multiple tracer studies, and improved understanding of the uptake of different radiotracers, such that the transitional biology of dysfunctional subcellular catecholamine handling can be distinguished from complete denervation. As a result, sympathetic neuronal molecular imaging is poised to play a role in individualized patient care, by stratifying cardiovascular risk, visualizing underlying biology, and guiding and monitoring therapy.

  4. Imaginative Experience: A Narrative-Dialogic Ethnography of the Community Who Adores Its Idol

    Directory of Open Access Journals (Sweden)

    Eka Ardianto

    2007-09-01

    Full Text Available Managing customer loyalty becomes an important activity in marketing management. One of the reasons is that loyal consumers tend to make good financial performances to producer. Unfortunately, gaining a loyal customer is not a trivial activity since there are gaps to understand consumer experience comprehensively. To fulfill the gaps, this article explores imaginative experience of the community who adores its idol in the light of cultural perspective. The members of the community who adores its idol experience the imaginative experience. The author argues that those phenomena are cultural perspective, because they are meaningful to the members. Through narrative-dialogic ethnography, the author builds the concept of imaginative experience that through the imaginative media, the members do narrative-dialogic between “the realm of areal” and “the realm of afotik” then activate the imaginative relations in “the realm of aktinik”. Every member constructs its imaginative relations into imaginative constructions formed in a personal story. Managing imaginative experience could benefit the company. It can be the “Imaginative Experience Management” (IEM that accommodates imaginative consumers’ experiences with the company’s products deeply and sustainably through managing the story of its consumers’ imaginative experiences. It can also be linked to the customer loyalty programs. In this matter, IEM should be integrated with brand management.

  5. [Alkylating agents].

    Science.gov (United States)

    Pourquier, Philippe

    2011-11-01

    With the approval of mechlorethamine by the FDA in 1949 for the treatment of hematologic malignancies, alkylating agents are the oldest class of anticancer agents. Even though their clinical use is far beyond the use of new targeted therapies, they still occupy a major place in specific indications and sometimes represent the unique option for the treatment of refractory diseases. Here, we are reviewing the major classes of alkylating agents and their mechanism of action, with a particular emphasis for the new generations of alkylating agents. As for most of the chemotherapeutic agents used in the clinic, these compounds are derived from natural sources. With a complex but original mechanism of action, they represent new interesting alternatives for the clinicians, especially for tumors that are resistant to conventional DNA damaging agents. We also briefly describe the different strategies that have been or are currently developed to potentiate the use of classical alkylating agents, especially the inhibition of pathways that are involved in the repair of DNA lesions induced by these agents. In this line, the development of PARP inhibitors is a striking example of the recent regain of interest towards the "old" alkylating agents.

  6. The effects of mood upon imaginal thought.t.

    Science.gov (United States)

    Blum, G S; Green, M

    1978-06-01

    The effects of mood upon imaginal thought were explored with a highly trained undergraduate female hypnotic subject. She was hypnotically programmed to experience free-floating anxiety or pleasure in varying degrees just before the exposure of combinations of three Blacky Pictures, and to produce dreamlike imagery in response to the Blacky stimuli while under sway of the mood. Data from 98 dream trials, separated by amnesia, indicated that the affective states clearly influenced imaginal processes. Blind ratings by a psychoanalyst showed anxiety moods to be more closely associated with primary-process features characteristic of nocturnal dreams, whereas pleasure had a relatively higher incidence of daydreamlike ratings. Empirical analysis of themes yielded significant relationships of anxiety to physical injury to the self and verbal aggression toward others; pleasure was associated with circular movements and overt sex themes.

  7. THE ROLE OF IMAGINATION IN ATTAINING THE KNOWLEDGE OF GOD

    Directory of Open Access Journals (Sweden)

    TATIANA BORODAI

    2010-08-01

    Full Text Available In this article, the author wishes to defend a fundamental point: most ancient and early Christian thinkers (from Augustine to Thomas Aquinas thought that the human imagination as a cognitive faculty was a hindrance to metaphysical thinking, to theology, and therefore to the beatifi c vision and salvation. Today, on the contrary, this cognitive faculty is considered to be a positive and very valuable one. The turning-point in the process of this re-evaluation is located in the fourteenth century, when a new literary genre of spiritual literature appeared — the meditationes vitae Christi. For the fi rst time, imagination was seen as a most effi cient tool for attaining a knowledge of God and the fi nal goal of man’s life.

  8. Emotion rendering in auditory simulations of imagined walking styles

    DEFF Research Database (Denmark)

    Turchet, Luca; Rodá, Antonio

    2016-01-01

    This paper investigated how different emotional states of a walker can be rendered and recognized by means of footstep sounds synthesis algorithms. In a first experiment, participants were asked to render, according to imagined walking scenarios, five emotions (aggressive, happy, neutral, sad......, and tender) by manipulating the parameters of synthetic footstep sounds simulating various combinations of surface materials and shoes types. Results allowed to identify, for the involved emotions and sound conditions, the mean values and ranges of variation of two parameters, sound level and temporal...... distance between consecutive steps. Results were in accordance with those reported in previous studies on real walking, suggesting that expression of emotions in walking is independent from the real or imagined motor activity. In a second experiment participants were asked to identify the emotions...

  9. Machado de Assis, moral imagination and the novel

    Directory of Open Access Journals (Sweden)

    José Luiz Passos

    Full Text Available The article discusses the premise behind binding literary value to the ability a work has to yield socio-historical information, prevalent in recent criticism on Machado de Assis. It argues that the body of Machado's work shows an increasing ambivalence regarding the links between imagined lives and history, thus proposing that in his late writings the matching between things real and things represented is a rhetorical and melancholy gesture of great insight. In order to illustrate the prevalence of moral imagination as object and technique in Machado's late novels, the author highlights a few points of contact between Machado de Assis and Henry James, contemporaries and akin in their literary sensibilities.

  10. The Sociological Imagination and Its Promise Fifty Years Later

    Directory of Open Access Journals (Sweden)

    Carlos Frade

    2009-11-01

    Full Text Available This paper offers a restatement of Wright Mills’ The Sociological Imagination and tries to judge whether its promise can be credibly renewed today by addressing the question about the present and future possibilities of the social sciences as free forms of enquiry. Relying on Weber, Mills and other thinkers, the paper sustains that the possibilities for a truly free social science essentially depend on three major ‘conditions’: the subjective stance or vocation, the sociological imagination proper, and an independent social science politics, conditions whose apt names can also be ‘love’, ‘insight’ and ‘courage’. An analysis of the presence and strength of each of these conditions in contemporary social science and in academia shows the magnitude of the task faced for the existence of a free social science.

  11. Quando o imaginário se diz educacional

    OpenAIRE

    Araújo, Alberto Filipe

    2010-01-01

    O imaginário educacional é devedor da concepção romântica de educação que privilegia a formação da interioridade do sujeito (daquilo que Jung denomina de das Selbst : o si-mesmo) por meio de uma viagem iniciática sob a forma, por exemplo, do "romance de formação". Daí a necessidade de se estruturar, mediante uma hermenêutica adequada, aquilo que constitui a sustância do imaginário educacional (alegorias, metáforas, símbolos, ideologemas e mitos), ainda que este apareça de um modo geral degrad...

  12. Imaginative Geographies, Dracula and the Transylvania ‘Place Myth’

    Directory of Open Access Journals (Sweden)

    Duncan Light

    2008-11-01

    Full Text Available Imaginative geographies have become a central concept in Anglo-American cultural geography in recent years. We all form knowledge, ideas and beliefs in our minds about what other places are ‘like’. In some cases these ideas may so strong that a distinct place ‘myth’ develops. In this paper I focus on the Western place myth of Transylvania. In the Western imagination this region has come to be constructed as a remote, backward, sinister place on the very edge of Europe, where vampires and the supernatural reign unchecked. I examine the historical development of this place myth in the West with particular reference to the role of popular culture in reproducing and circulating this myth on a global scale. I also seek to situate this place myth in its broader historical, political and social contexts.

  13. Allergy to uncommon pets: new allergies but the same allergens.

    Directory of Open Access Journals (Sweden)

    Araceli eDiaz-Perales

    2013-12-01

    Full Text Available The prevalence of exotic pet allergies has been increasing over the last decade. Years ago, the main allergy-causing domestic animals were dogs and cats, although nowadays there is an increasing number of allergic diseases related to insects, rodents, amphibians, fish, and birds, among others. The current socio-economic situation, in which more and more people have to live in small apartments, might be related to this tendency. The main allergic symptoms related to exotic pets are the same as those described for dog and cat allergy: respiratory symptoms. Animal allergens are therefore, important sensitizing agents and an important risk factor for asthma. There are 3 main protein families implicated in these allergies, which are the lipocalin superfamily, serum albumin family, and secretoglobin superfamily. Detailed knowledge of the characteristics of allergens is crucial to improvement treatment of uncommon-pet allergies.

  14. The Humanities, Human Rights, and the Comparative Imagination

    OpenAIRE

    McClennen, Sophia A.

    2007-01-01

    In her paper "The Humanities, Human Rights, and the Comparative Imagination" Sophia A. McClennen argues that understanding the relationship between culture and human rights depends on humanist perspectives attentive to the relationship between storytelling and identity, mass culture and ideology, text and audience, critical thinking and engaged citizenship. After briefly considering how the divide between the humanities and human rights advocates developed and how it might best be overcome, s...

  15. Anomalies of Imagination and Disordered Self in Schizophrenia Spectrum Disorders

    DEFF Research Database (Denmark)

    Rasmussen, Andreas Christian Rosén; Parnas, Josef

    2015-01-01

    Vivid mental imagery occurs frequently in schizophrenia spectrum disorders (SSDs). Overlapping phenomena, such as obsessions or ruminations, are also frequent in other psychiatric disorders, raising significant diagnostic challenges. Unfortunately, contemporary operational psychopathology lacks...... the epistemological and phenomenological framework to address such questions. Using the resources of phenomenology and philosophy of mind, we articulate the structure of imagination and describe its distinctive modifications in the SSDs. Drawing on pilot data with patients' self-descriptions, we present the notion...

  16. Agents' Social Imagination: The "Invisible" Hand of Neoliberalism in Taiwan's Curriculum Reform

    Science.gov (United States)

    Huang, Teng

    2012-01-01

    Neoliberalism has become the most dominant ideology in current world and educational researchers thus may need to disclose the ways in which neoliberalism affects education and curriculum and propose new strategies to cope with them. Through literature review, however, the author argues that perhaps because of the social and theoretical scope in…

  17. PET or PET-CT with cancer screening

    International Nuclear Information System (INIS)

    Wang Taisong; Zhao Jinhua; Song Jianhua

    2007-01-01

    At present, cancer screening remains a lot of debate in contemporary medical practice. Many constitutes have done a lot of experiments in cancer screening. The same version is that recommendations and decisions regarding cancer screening should be based on reliable data, not self- approbation. Now, some institutes advocate 18 F-FDG PET or 18 F-FDG PET-CT for cancer screening, here, discussed status quo, potential financial, radiation safety and statistical data in 18 F-FDG PET or 18 F-FDG PET- CT cancer screening. (authors)

  18. Technical considerations on scanning and image analysis for amyloid PET in dementia

    International Nuclear Information System (INIS)

    Akamatsu, Go; Ohnishi, Akihito; Aita, Kazuki; Ikari, Yasuhiko; Senda, Michio; Yamamoto, Yasuji

    2017-01-01

    Brain imaging techniques, such as computed tomography (CT), magnetic resonance imaging (MRI), single photon emission computed tomography (SPECT), and positron emission tomography (PET), can provide essential and objective information for the early and differential diagnosis of dementia. Amyloid PET is especially useful to evaluate the amyloid-β pathological process as a biomarker of Alzheimer's disease. This article reviews critical points about technical considerations on the scanning and image analysis methods for amyloid PET. Each amyloid PET agent has its own proper administration instructions and recommended uptake time, scan duration, and the method of image display and interpretation. In addition, we have introduced general scanning information, including subject positioning, reconstruction parameters, and quantitative and statistical image analysis. We believe that this article could make amyloid PET a more reliable tool in clinical study and practice. (author)

  19. Technical Considerations on Scanning and Image Analysis for Amyloid PET in Dementia.

    Science.gov (United States)

    Akamatsu, Go; Ohnishi, Akihito; Aita, Kazuki; Ikari, Yasuhiko; Yamamoto, Yasuji; Senda, Michio

    2017-01-01

    Brain imaging techniques, such as computed tomography (CT), magnetic resonance imaging (MRI), single photon emission computed tomography (SPECT), and positron emission tomography (PET), can provide essential and objective information for the early and differential diagnosis of dementia. Amyloid PET is especially useful to evaluate the amyloid-β pathological process as a biomarker of Alzheimer's disease. This article reviews critical points about technical considerations on the scanning and image analysis methods for amyloid PET. Each amyloid PET agent has its own proper administration instructions and recommended uptake time, scan duration, and the method of image display and interpretation. In addition, we have introduced general scanning information, including subject positioning, reconstruction parameters, and quantitative and statistical image analysis. We believe that this article could make amyloid PET a more reliable tool in clinical study and practice.

  20. MicroPET imaging and transgenic models: a blueprint for Alzheimer's disease clinical research.

    Science.gov (United States)

    Zimmer, Eduardo R; Parent, Maxime J; Cuello, A Claudio; Gauthier, Serge; Rosa-Neto, Pedro

    2014-11-01

    Over the past decades, developments in neuroimaging have significantly contributed to the understanding of Alzheimer's disease (AD) pathophysiology. Specifically, positron emission tomography (PET) imaging agents targeting amyloid deposition have provided unprecedented opportunities for refining in vivo diagnosis, monitoring disease propagation, and advancing AD clinical trials. Furthermore, the use of a miniaturized version of PET (microPET) in transgenic (Tg) animals has been a successful strategy for accelerating the development of novel radiopharmaceuticals. However, advanced applications of microPET focusing on the longitudinal propagation of AD pathophysiology or therapeutic strategies remain in their infancy. This review highlights what we have learned from microPET imaging in Tg models displaying amyloid and tau pathology, and anticipates cutting-edge applications with high translational value to clinical research. Copyright © 2014 Elsevier Ltd. All rights reserved.

  1. Student mathematical imagination instruments: construction, cultural adaptation and validity

    Science.gov (United States)

    Dwijayanti, I.; Budayasa, I. K.; Siswono, T. Y. E.

    2018-03-01

    Imagination has an important role as the center of sensorimotor activity of the students. The purpose of this research is to construct the instrument of students’ mathematical imagination in understanding concept of algebraic expression. The researcher performs validity using questionnaire and test technique and data analysis using descriptive method. Stages performed include: 1) the construction of the embodiment of the imagination; 2) determine the learning style questionnaire; 3) construct instruments; 4) translate to Indonesian as well as adaptation of learning style questionnaire content to student culture; 5) perform content validation. The results stated that the constructed instrument is valid by content validation and empirical validation so that it can be used with revisions. Content validation involves Indonesian linguists, english linguists and mathematics material experts. Empirical validation is done through a legibility test (10 students) and shows that in general the language used can be understood. In addition, a questionnaire test (86 students) was analyzed using a biserial point correlation technique resulting in 16 valid items with a reliability test using KR 20 with medium reability criteria. While the test instrument test (32 students) to find all items are valid and reliability test using KR 21 with reability is 0,62.

  2. Remapping Capricornia: Xavier Herbert’s Cosmopolitan Imagination

    Directory of Open Access Journals (Sweden)

    Ellen Smith

    2017-11-01

    Full Text Available Since its publication in 1938 critics have generally read Xavier Herbert’s Capricornia as a nationalist novel, even when its nationalism is seen to be structured by contradiction. But little attention has been given to the ways in which Herbert’s complex, multifarious and heteroglossic novel exceeds and challenges the very possibility of coherent national space and a coherent national story. This essay considers moments and spaces in Herbert’s novel where the national is displaced and unravelled. Drawing on Rebecca Walkowitz’s idea of cosmopolitan style and Suvendrini Perera’s work on Australia’s insular imagination I identify a critical cosmopolitanism that inheres in the novel’s geographical imagination and its literary form, particularly the narrative voice which retains a critical distance from the nationalist sensibility of various characters and plot lines, performing a detached and restless homelessness that I identify with the cosmopolitan. Ultimately I ask how the novel’s spatial and environmental imagination displaces its nationalist agenda, making space for a different kind of social imagination—one that does not confine itself to the terms of the nation or organise itself around a central figure for the nation.

  3. Pilot testing a digital pet avatar for older adults.

    Science.gov (United States)

    Chi, Nai-Ching; Sparks, Olivia; Lin, Shih-Yin; Lazar, Amanda; Thompson, Hilaire J; Demiris, George

    Social isolation in older adults is a major public health concern. An embodied conversational agent (ECA) has the potential to enhance older adults' social interaction. However, little is known about older adults' experience with an ECA. In this paper, we conducted a pilot study to examine the perceived acceptance and utility of a tablet-based conversational agent in the form of an avatar (termed "digital pet") for older adults. We performed secondary analysis of data collected from a study that employed the use of a digital pet in ten older adults' homes for three months. Most of the participants enjoyed the companionship, entertainment, reminders, and instant assistance from the digital pet. However, participants identified limited conversational ability and technical issues as system challenges. Privacy, dependence, and cost were major concerns. Future applications should maximize the agent's conversational ability and the system's overall usability. Our results can inform future designs of conversational agents for older adults, which need to include older adults as system co-designers to maximize usability and acceptance. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Read the Label First: Protect Your Pets

    Science.gov (United States)

    Learn about the importance of reading pet products labels before purchasing and using any product to insure the safety of your pets. Find tips for ways to reduce the changes of pets accessing potentially dangerous products.

  5. Cyclotron/PET project in Uruguay

    International Nuclear Information System (INIS)

    Engler, H.

    2006-01-01

    The Positron Computed Tomography (PET) is a tri dimensional image technique which shows biochemical information. PET is used in neurology and cardiology diseases. The National Center Cyclotron PET has been found to research, development and health science applications.

  6. A cidade imaginada ou o imaginário da cidade The city imagined, or the city’s imaginary

    Directory of Open Access Journals (Sweden)

    Maria Aparecida Lopes Nogueira

    1998-06-01

    Full Text Available O artigo trata da temática da cidade real-cidade imaginária. Argumenta que, ao refletirmos sobre a cidade, refletimos, também, sobre nós mesmos, com todos os nossos sonhos, frustrações, ansiedades e esperanças. A discussão parte de uma ciência reencantada, que aproxima as questões do cotidiano, da memória, do símbolo e do mito.Exploring the topic ‘actual city/imagined city’, the article argues that when we reflect on the question of city, we are also reflecting upon ourselves - including all our dreams, frustrations, anxieties, and hopes. This discussion is made possible by a science that interrelates the issues of daily life, of memory, of symbol and of myth.

  7. PET studies in dementia

    International Nuclear Information System (INIS)

    Herholz, K.

    2003-01-01

    Measurement of local cerebral glucose metabolism (lCMRGlc) by positron emission tomography (PET) and 18 F-2-fluoro-2-deoxy-D-glucose (FDG) has become a standard technique during the past 20 years and is now available at many university hospitals in all highly developed countries. Many studies have documented a close relation between lCMRGlc and localized cognitive functions, such as language and visuoconstructive abilities. Alzheimer's disease (AD) is characterized by regional impairment of cerebral glucose metabolism in neocortical association areas (posterior cingulate, temporoparietal and frontal multimodal association cortex), whereas primary visual and sensorimotor cortex, basal ganglia, and cerebellum are relatively well preserved. In a multicenter study comprising 10 PET centers (Network for Efficiency and Standardization of Dementia Diagnosis, NEST-DD) that employed an automated voxel-based analysis of FDG PET images, the distinction between controls and AD patients was 93% sensitive and 93% specific, and even in very mild dementia (at Mini Mental Status Examination (MMSE) 24 or higher) sensitivity was still 84% at 93% specificity. Significantly abnormal metabolism in mild cognitive deficit (MCI) indicates a high risk to develop dementia within the next two years. Reduced neocortical glucose metabolism can probably be detected with FDG PET in AD on average one year before onset of subjective cognitive impairment. In addition to glucose metabolism, specific tracers for dopamine synthesis ( 18 F-F-DOPA) and for ( 11 C-MP4A) are of interest for differentiation among dementia subtypes. Cortical acetylcholine esterase activity (AChE) activity is significantly lower in patients with AD or with dementia with Lewy bodies (DLB) than in age-matched normal controls. In LBD there is also impairment of dopamine synthesis, similar to Parkinson disease. (author) 115 refs

  8. PET studies in dementia

    Energy Technology Data Exchange (ETDEWEB)

    Herholz, K. [Neurologische Universitaetsklinik and Max-Planck-Inst. fuer neurologische Forschung, Koeln (Germany)

    2003-04-01

    Measurement of local cerebral glucose metabolism (lCMRGlc) by positron emission tomography (PET) and {sup 18}F-2-fluoro-2-deoxy-D-glucose (FDG) has become a standard technique during the past 20 years and is now available at many university hospitals in all highly developed countries. Many studies have documented a close relation between lCMRGlc and localized cognitive functions, such as language and visuoconstructive abilities. Alzheimer's disease (AD) is characterized by regional impairment of cerebral glucose metabolism in neocortical association areas (posterior cingulate, temporoparietal and frontal multimodal association cortex), whereas primary visual and sensorimotor cortex, basal ganglia, and cerebellum are relatively well preserved. In a multicenter study comprising 10 PET centers (Network for Efficiency and Standardization of Dementia Diagnosis, NEST-DD) that employed an automated voxel-based analysis of FDG PET images, the distinction between controls and AD patients was 93% sensitive and 93% specific, and even in very mild dementia (at Mini Mental Status Examination (MMSE) 24 or higher) sensitivity was still 84% at 93% specificity. Significantly abnormal metabolism in mild cognitive deficit (MCI) indicates a high risk to develop dementia within the next two years. Reduced neocortical glucose metabolism can probably be detected with FDG PET in AD on average one year before onset of subjective cognitive impairment. In addition to glucose metabolism, specific tracers for dopamine synthesis ({sup 18}F-F-DOPA) and for ({sup 11}C-MP4A) are of interest for differentiation among dementia subtypes. Cortical acetylcholine esterase activity (AChE) activity is significantly lower in patients with AD or with dementia with Lewy bodies (DLB) than in age-matched normal controls. In LBD there is also impairment of dopamine synthesis, similar to Parkinson disease. (author) 115 refs.

  9. Pet Overpopulation: An Economic Analysis

    OpenAIRE

    Stephen Coate; Brian Knight

    2009-01-01

    This paper considers the problem of pet overpopulation. It develops a tractable dynamic model whose positive predictions square well with key features of the current U.S. market for pets. The model is used to understand, from a welfare economic perspective, the sense in which there is \\overpopulation" of pets and the underlying causes of the problem. The paper also employs the model to consider what policies might be implemented to deal with the problem. A calibrated example is developed to i...

  10. Click synthesis of PET radiopharmaceuticals

    International Nuclear Information System (INIS)

    Xu Mei; Kuang Chunxiang

    2009-01-01

    Increasing attention has been focused on synthesis radiopharmaceuticals for positron emission tomography (PET). The recent years witnessed applications of click chemistry to PET radiopharmaceutical synthesis,because of its distinctive advantages including high speed,yield and stereospecificity under mild conditions. Synthesis of 18 F-labeled and 11 C-labeled radiopharmaceuticals and intermediates via click chemistry are reviewed. The future trend of click chemistry for the synthesis of PET radiopharmaceutical is prospected. (authors)

  11. PET and Recycling

    Directory of Open Access Journals (Sweden)

    Funda Sevencan

    2007-08-01

    Full Text Available This review aims to clarify the need of decreasing the environmental effects caused by human and draw attention to the increasing environmental effects of plastics wastes. Plastics consist of organic molecules with high density molecules or polymers. Main resources of plastics are the residue of oil rafineries. Several advantages of plastics, have increased the usage continuously. Polyethylene Terephthalate (PET is the most commonly used plastics. PET is used to protect food, drinking water, fruit juice, alcoholic beverage, and food packing films. By the increasing interest on the environmental effects of plastic wastes, concerns on the recyclable packing materials also grew up. Also the daily use of recyclable containers consisting PET have increased. There are five steps for recycling of plastics. These steps are; using large amounts of plastics, collecting them in a big center, classifying and sorting the plastics, reproducing the polymers and obtaining new products with melted plastics. Providing a healthy recycling of plastics, the consumers should have knowledge and responsibility. The consumer should know what he/she has to do before putting the plastics in the recycling containers. Recycling containers and bags should be placed near the sources of plastic wastes. Consequently, the plastic wastes and environmental problems they cause will be on the agenda in future. [TAF Prev Med Bull. 2007; 6(4: 307-312

  12. PET and Recycling

    Directory of Open Access Journals (Sweden)

    Funda Sevencan

    2007-08-01

    Full Text Available This review aims to clarify the need of decreasing the environmental effects caused by human and draw attention to the increasing environmental effects of plastics wastes. Plastics consist of organic molecules with high density molecules or polymers. Main resources of plastics are the residue of oil rafineries. Several advantages of plastics, have increased the usage continuously. Polyethylene Terephthalate (PET is the most commonly used plastics. PET is used to protect food, drinking water, fruit juice, alcoholic beverage, and food packing films. By the increasing interest on the environmental effects of plastic wastes, concerns on the recyclable packing materials also grew up. Also the daily use of recyclable containers consisting PET have increased. There are five steps for recycling of plastics. These steps are; using large amounts of plastics, collecting them in a big center, classifying and sorting the plastics, reproducing the polymers and obtaining new products with melted plastics. Providing a healthy recycling of plastics, the consumers should have knowledge and responsibility. The consumer should know what he/she has to do before putting the plastics in the recycling containers. Recycling containers and bags should be placed near the sources of plastic wastes. Consequently, the plastic wastes and environmental problems they cause will be on the agenda in future. [TAF Prev Med Bull 2007; 6(4.000: 307-312

  13. Extended suicide with a pet.

    Science.gov (United States)

    Cooke, Brian K

    2013-01-01

    The combination of the killing of a pet and a suicide is a perplexing scenario that is largely unexplored in the literature. Many forensic psychiatrists and psychologists may be unaccustomed to considering the significance of the killing of a pet. The subject is important, however, because many people regard their pets as members of their family. A case is presented of a woman who killed her pet dog and herself by carbon monoxide poisoning. The purpose of this article is to provide an initial exploration of the topic of extended suicide with a pet. Forensic mental health evaluations may have a role in understanding the etiology of this event and in opining as to the culpability of individuals who attempt to or successfully kill a pet and then commit suicide. Because the scientific literature is lacking, there is a need to understand this act from a variety of perspectives. First, a social and anthropological perspective will be presented that summarizes the history of the practice of killing of one's pet, with a focus on the ancient Egyptians. A clinical context will examine what relationship animals have to mental illness. A vast body of existing scientific data showing the relevance of human attachment to pets suggests that conclusions from the phenomena of homicide-suicide and filicide-suicide are applicable to extended suicide with a pet. Finally, recommendations will be proposed for both clinical and forensic psychiatrists faced with similar cases.

  14. PET/CT and radiotherapy

    International Nuclear Information System (INIS)

    Messa, C.; CNR, Milano; S. Gerardo Hospital, Monza; Di Muzio, N.; Picchio, M.; Bettinardi, V.; Gilardi, M.C.; CNR, Milano; San Raffaele Scientific Institute, Milano; Fazio, F.; CNR, Milano; San Raffaele Scientific Institute, Milano; San Raffaele Scientific Institute, Milano

    2006-01-01

    This article reviews the state of the art of PET/CT applications in radiotherapy, specifically its use in disease staging, patient selection, treatment planning and treatment evaluation. Diseases for which radiotherapy with radical intent is indicated will be considered, as well as those in which PET/CT may actually change the course of disease. The methodological and technological aspects of PET/CT in radiotherapy are discussed, focusing on the problem of target volume definition with CT and PET functional imaging and the problem of tumor motion with respect to imaging and dose delivery

  15. Drawing Links between the Autism Cognitive Profile and Imagination: Executive Function and Processing Bias in Imaginative Drawings by Children with and without Autism

    Science.gov (United States)

    Ten Eycke, Kayla D.; Müller, Ulrich

    2018-01-01

    Little is known about the relation between cognitive processes and imagination and whether this relation differs between neurotypically developing children and children with autism. To address this issue, we administered a cognitive task battery and Karmiloff-Smith's drawing task, which requires children to draw imaginative people and houses. For…

  16. Imagining the future: evidence for a hippocampal contribution to constructive processing.

    Science.gov (United States)

    Gaesser, Brendan; Spreng, R Nathan; McLelland, Victoria C; Addis, Donna Rose; Schacter, Daniel L

    2013-12-01

    Imagining future events and remembering past events rely on a common core network, but several regions within this network--including the hippocampus--show increased activity for imagining future events compared to remembering past events. It remains unclear whether this hippocampal activity reflects processes related to the demands of constructing details retrieved across disparate episodic memories into coherent imaginary events, encoding these events into memory, novelty detection, or some combination of these processes. We manipulated the degree of constructive processing by comparing activity associated with the initial construction of an imagined scenario with the re-construction of an imagined scenario (imagine vs. re-imagine). After accounting for effects of novelty and subsequent memory, we found that a region in the hippocampus was preferentially activated for newly constructed imagined events compared with re-imagined events. Our results suggest that the hippocampus may support several distinct but related processes that are critical for imagining future events, and they also indicate that a particular region within posterior hippocampus may uniquely contribute to the construction of imagined future events. Copyright © 2013 Wiley Periodicals, Inc.

  17. Progression of Chinese Students' Creative Imagination from Elementary Through High School

    Science.gov (United States)

    Ren, Fujun; Li, Xiuju; Zhang, Huiliang; Wang, Lihui

    2012-09-01

    For almost a century, researchers have studied creative imagination, most typically that of children. This article reports on a study of the development of creative imagination of Chinese youths and its relation to the educational environment. Data consisted of 4,162 students from grades 4 through 12. Findings showed that students' creative imagination increased as the grade in school increased from grades 4 through 11, but decreased slightly at grade 12. Students' creative imagination was lower in elementary school than that in middle school. The pace of development was also different in different stages. In different grades, youths used different ways to express their imagination. Students of 'excellent' academic performance had the highest creative imagination, followed by students of 'fairly good', 'medium' and 'poor' academic performance. Student-centred teaching methods were associated with higher creative imagination. Students whose teachers had a more supportive attitude showed better creative imagination. Finally, taking part in science-related competitions and frequently visiting science venues were related to the development of students' creative imagination. Some implications and recommendations for development of students' creative imagination are also proposed.

  18. Cost-effectiveness of PET and PET/Computed Tomography

    DEFF Research Database (Denmark)

    Gerke, Oke; Hermansson, Ronnie; Hess, Søren

    2015-01-01

    measure by means of incremental cost-effectiveness ratios when considering the replacement of the standard regimen by a new diagnostic procedure. This article discusses economic assessments of PET and PET/computed tomography reported until mid-July 2014. Forty-seven studies on cancer and noncancer...

  19. Report on the development and application of PET/CT in mainland China.

    Science.gov (United States)

    Chen, Yumei; Chen, Ruohua; Zhou, Xiang; Liu, Jianjun; Huang, Gang

    2017-09-08

    To examine the development and application of systems combining positron emission and x-ray-computed tomography systems (PET/CTs) in mainland China. Using a questionnaire, we surveyed Chinese medical institutions on a variety topics relating to their PET/CT systems and its use. The respondents had PET/CTs installed and in clinical use before 31 December 2015. We examined the clinical scenarios to which Chinese PET/CTs were applied by reviewing the related Chinese and international literature from the start of 1995 to the end of 2013; these papers were found by searching the Wanfang and PubMed databases, respectively. The data were then classified and analyzed statistically. At the end of 2015, there were 240 PET/CTs and 101 medical cyclotrons in mainland China. The total number of PET studies performed in 2015 was 469,364. The main clinical applications of PET were found to be diagnostic fludeoxyglucose ( 18 F-FDG) imaging and oncological imaging. A minority of PET/CT studies were performed using 11 C-choline and other imaging agents. The number of papers relating to clinical use of PET/CT in mainland China increased each year over the period of study, in both the Chinese and international literature. Despite this progress, important problems were also apparent, including unbalanced regional development and the limited quality of the research. This study provides detailed information for understanding the development PET/CT technology in mainland China, along with its geographical distribution and clinical application. It may thus prove a useful reference for all those involved in planning the future of PET/CT in China.

  20. Simultaneous PET-MRI in Oncology: A Solution Looking for a Problem?

    Science.gov (United States)

    Yankeelov, Thomas E.; Peterson, Todd E.; Abramson, Richard G.; Garcia-Izquierdo, David; Arlinghaus, Lori R.; Li, Xia; Atuegwu, Nkiruka C.; Catana, Ciprian; Manning, H. Charles; Fayad, Zahi A.; Gore, John C.

    2012-01-01

    With the recent development of integrated positron emission tomography-magnetic resonance imaging (PET-MRI) scanners, new possibilities for quantitative molecular imaging of cancer are realized. However, the practical advantages and potential clinical benefits of the ability to record PET and MRI data simultaneously must be balanced against the substantial costs and other requirements of such devices. In this review we highlight several of the key areas where integrated PET-MRI measurements, obtained simultaneously, are anticipated to have a significant impact on clinical and/or research studies. These areas include the use of MR-based motion corrections and/or a priori anatomical information for improved reconstruction of PET data; improved arterial input function characterization for PET kinetic modeling; the use of dual-modality contrast agents; and patient comfort and practical convenience. For widespread acceptance, a compelling case could be made if the combination of quantitative MRI and specific PET biomarkers significantly improves our ability to assess tumor status and response to therapy, and some likely candidates are now emerging. We consider the relative advantages and disadvantages afforded by PET-MRI and summarize current opinions and evidence as to the likely value of PET-MRI in the management of cancer. PMID:22795930

  1. Chemical Agents

    Science.gov (United States)

    ... CR) see Riot Control Agents Digitalis Distilled mustard (HD) see Sulfur mustard E Ethylene glycol F Fentanyls and other opioids H Hydrazine Hydrofluoric acid (hydrogen fluoride) Hydrogen chloride Hydrogen cyanide (AC) Hydrogen ...

  2. Progress on dedicated animal PET

    International Nuclear Information System (INIS)

    Liu Wei

    2002-01-01

    Positron emission tomography, as the leading technology providing molecular imaging of biological processes, is widely used on living laboratory animals. High-resolution dedicated animal PET scanners have been developed. Although the dedicated animal PET faces obstacles and challenges, this advanced technology would play an important role in molecular biomedicine researches, such as diseases study, medicine development, and gene therapy

  3. Small Molecule PET-Radiopharmaceuticals

    NARCIS (Netherlands)

    Elsinga, Philip H.; Dierckx, Rudi A. J. O.

    This review describes several aspects required for the development of small molecule PET-tracers. Design and selection criteria are important to consider before starting to develop novel PET-tracers. Principles and latest trends in C-11 and F-18-radiochemistry are summarized. In addition an update

  4. Welfare assessment in pet rabbits

    NARCIS (Netherlands)

    Schepers, F.; Koene, P.; Beerda, B.

    2009-01-01

    One million pet rabbits are kept in The Netherlands, but there are no data available on their behaviour and welfare. This study seeks to assess the welfare of pet rabbits in Dutch households and is a first step in the development of a welfare assessment system. In an internet survey, housing

  5. Selected PET radiomic features remain the same.

    Science.gov (United States)

    Tsujikawa, Tetsuya; Tsuyoshi, Hideaki; Kanno, Masafumi; Yamada, Shizuka; Kobayashi, Masato; Narita, Norihiko; Kimura, Hirohiko; Fujieda, Shigeharu; Yoshida, Yoshio; Okazawa, Hidehiko

    2018-04-17

    We investigated whether PET radiomic features are affected by differences in the scanner, scan protocol, and lesion location using 18 F-FDG PET/CT and PET/MR scans. SUV, TMR, skewness, kurtosis, entropy, and homogeneity strongly correlated between PET/CT and PET/MR images. SUVs were significantly higher on PET/MR 0-2 min and PET/MR 0-10 min than on PET/CT in gynecological cancer ( p = 0.008 and 0.008, respectively), whereas no significant difference was observed between PET/CT, PET/MR 0-2 min , and PET/MR 0-10 min images in oral cavity/oropharyngeal cancer. TMRs on PET/CT, PET/MR 0-2 min , and PET/MR 0-10 min increased in this order in gynecological cancer and oral cavity/oropharyngeal cancer. In contrast to conventional and histogram indices, 4 textural features (entropy, homogeneity, SRE, and LRE) were not significantly different between PET/CT, PET/MR 0-2 min , and PET/MR 0-10 min images. 18 F-FDG PET radiomic features strongly correlated between PET/CT and PET/MR images. Dixon-based attenuation correction on PET/MR images underestimated tumor tracer uptake more significantly in oral cavity/oropharyngeal cancer than in gynecological cancer. 18 F-FDG PET textural features were affected less by differences in the scanner and scan protocol than conventional and histogram features, possibly due to the resampling process using a medium bin width. Eight patients with gynecological cancer and 7 with oral cavity/oropharyngeal cancer underwent a whole-body 18 F-FDG PET/CT scan and regional PET/MR scan in one day. PET/MR scans were performed for 10 minutes in the list mode, and PET/CT and 0-2 min and 0-10 min PET/MR images were reconstructed. The standardized uptake value (SUV), tumor-to-muscle SUV ratio (TMR), skewness, kurtosis, entropy, homogeneity, short-run emphasis (SRE), and long-run emphasis (LRE) were compared between PET/CT, PET/MR 0-2 min , and PET/MR 0-10 min images.

  6. Neurotransmission imaging by PET

    Energy Technology Data Exchange (ETDEWEB)

    Takano, Akihiro; Suhara, Tetsuya [National Inst. of Radiological Sciences, Chiba (Japan)

    2001-08-01

    PET studies on neurotransmission in psychological disorders to evaluate abnormal neurotransmission and therapeutic effects are thoroughly reviewed by type of major neurotransmitters. Studies on dopaminergic neurotransmission have focused on the function of dopamine D{sub 2} receptors, receptor subtypes, such as the D{sub 1} receptor, and ligands, such as transporters. PET studies of dopamine D{sub 2} receptor, which began in the early 1980s, have predominantly been performed in schizophrenia, and most have failed to detect any statistically significant differences between schizophrenia patients and controls. The studies in the early 1980s were performed by using [{sup 11}C]N-methyl-spiperone (NMSP) and [{sup 11}C]raclopride, ligands for striatal dopamine D{sub 2} receptors. [{sup 11}C]FLB457, which has much higher affinity for D{sub 2} receptors than raclopride, began to be used in the 1990s. Dopamine D{sub 2} occupancy after drug ingestion has also been investigated to clarify the mechanisms and effects of antipsychotic drugs, and there have also been studies on the effect of aging and personality traits on dopamine D{sub 2} receptor levels in healthy subjects. In studies on dopamine receptor subtypes other than D{sub 2}, dopamine D{sub 1} receptors have been studied in connection with assessments of cognitive functions. Most studies on dopamine transporters have been related to drug dependence. Serotonin 5-HT{sub 2A} receptors have been studied with [{sup 11}C]NMSP in schizophrenia patients, while studies of another serotonin receptor subtype, 5-HT{sub 1A} receptors, have been mainly conducted in patients with depression. [{sup 11}C]NMSP PET showed no difference between schizophrenia patients who had not undergone phamacotherapy and normal subjects. Because serotonin selective reuptake inhibitors (SSRIs) affect serotonin transporters, and abnormalities in serotonin transporters detected in mood disorders, PET ligands for serotonin transporters have increasingly

  7. Neurotransmission imaging by PET

    International Nuclear Information System (INIS)

    Takano, Akihiro; Suhara, Tetsuya

    2001-01-01

    PET studies on neurotransmission in psychological disorders to evaluate abnormal neurotransmission and therapeutic effects are thoroughly reviewed by type of major neurotransmitters. Studies on dopaminergic neurotransmission have focused on the function of dopamine D 2 receptors, receptor subtypes, such as the D 1 receptor, and ligands, such as transporters. PET studies of dopamine D 2 receptor, which began in the early 1980s, have predominantly been performed in schizophrenia, and most have failed to detect any statistically significant differences between schizophrenia patients and controls. The studies in the early 1980s were performed by using [ 11 C]N-methyl-spiperone (NMSP) and [ 11 C]raclopride, ligands for striatal dopamine D 2 receptors. [ 11 C]FLB457, which has much higher affinity for D 2 receptors than raclopride, began to be used in the 1990s. Dopamine D 2 occupancy after drug ingestion has also been investigated to clarify the mechanisms and effects of antipsychotic drugs, and there have also been studies on the effect of aging and personality traits on dopamine D 2 receptor levels in healthy subjects. In studies on dopamine receptor subtypes other than D 2 , dopamine D 1 receptors have been studied in connection with assessments of cognitive functions. Most studies on dopamine transporters have been related to drug dependence. Serotonin 5-HT 2A receptors have been studied with [ 11 C]NMSP in schizophrenia patients, while studies of another serotonin receptor subtype, 5-HT 1A receptors, have been mainly conducted in patients with depression. [ 11 C]NMSP PET showed no difference between schizophrenia patients who had not undergone phamacotherapy and normal subjects. Because serotonin selective reuptake inhibitors (SSRIs) affect serotonin transporters, and abnormalities in serotonin transporters detected in mood disorders, PET ligands for serotonin transporters have increasingly been developed, and serotonin transporters have recently begun to be

  8. Economic Imagination and Support For Parliamentary Democracy In Poland

    Directory of Open Access Journals (Sweden)

    Andrzej K. Koźmiński

    2014-06-01

    Full Text Available Purpose: The article introduces a concept of the economic imagination, describes economic public attitudes and discusses the character of the contemporary economic imagination of Poles. Methodology: Representative survey conducted on the stratifi ed random sample of 1022 adult respondents by means of CAPI (computer assisted personal interview. Statistical analysis of data. Findings: The features perceived by public as economically benefi cial to the entire economy, particular enterprises and individuals have been ranked by the representative survey and statistically grouped into more general clusters. Those considered as good for the economy are grouped into such factors as “investment and competition”, “statism (etatism” and “progressive taxation”. The features considered as benefi cial for the enterprises are grouped into “human, social and economic capital”, “law obedience and good social relations” and “limited free market”. Personal characteristics perceived as benefi cial for individual’s economic success are grouped into “honesty, perseverance and good social relations”, “skills and diligence” and “nepotism and instrumentalism”. Intensity as well as determinants of such general value loaded convictions, and their impact on acceptance of democracy have been revealed as well. The implications: Economic imagination has to be analysed as an important factor of socio-economic system’s legitimization. Originality: Distinction and empirical defi nition of economic attitudinal syndromes at three different levels: macro-economic, enterprise and individual constitute a novelty in socio-economic research. Discussion of their determinants and wider implications constitute a new contribution to the theory of social legitimization.

  9. Using imagination to understand the neural basis of episodic memory

    Science.gov (United States)

    Hassabis, Demis; Kumaran, Dharshan; Maguire, Eleanor A.

    2008-01-01

    Functional MRI (fMRI) studies investigating the neural basis of episodic memory recall, and the related task of thinking about plausible personal future events, have revealed a consistent network of associated brain regions. Surprisingly little, however, is understood about the contributions individual brain areas make to the overall recollective experience. In order to examine this, we employed a novel fMRI paradigm where subjects had to imagine fictitious experiences. In contrast to future thinking, this results in experiences that are not explicitly temporal in nature or as reliant on self-processing. By using previously imagined fictitious experiences as a comparison for episodic memories, we identified the neural basis of a key process engaged in common, namely scene construction, involving the generation, maintenance and visualisation of complex spatial contexts. This was associated with activations in a distributed network, including hippocampus, parahippocampal gyrus, and retrosplenial cortex. Importantly, we disambiguated these common effects from episodic memory-specific responses in anterior medial prefrontal cortex, posterior cingulate cortex and precuneus. These latter regions may support self-schema and familiarity processes, and contribute to the brain's ability to distinguish real from imaginary memories. We conclude that scene construction constitutes a common process underlying episodic memory and imagination of fictitious experiences, and suggest it may partially account for the similar brain networks implicated in navigation, episodic future thinking, and the default mode. We suggest that further brain regions are co-opted into this core network in a task-specific manner to support functions such as episodic memory that may have additional requirements. PMID:18160644

  10. Transpersonale Aspekte von Musik und Imagination in der Traumatherapie

    DEFF Research Database (Denmark)

    Maack, Carola

    2013-01-01

    Guided Imagery and Music nach Helen Bonny (GIM) und ihre Modifikationen haben sich in der Traumatherapie als sehr effektiv herausgestellt. In meinem Vortrag werde ich die Methode und ihre Anwendungen in der Traumatherapie vorstellen. Dabei gehe ich auch auf die Abgrenzung von Imagination im...... personalen und traunspersonalen Raum und deren jeweilige Bedeutung für traumatisierte Menschen in der unterschiedlichen Phasen ihrer Therapie ein. [The Bonny Methode of Guided Imagery and Music (GIM) and its modifications have shown to be quite effective in trauma therapy. In my presentation I will give...

  11. Perception, Imagination and Affect in Human–Robot Relationships

    Directory of Open Access Journals (Sweden)

    Erika Kerruish

    2016-11-01

    Full Text Available As they arrive in our homes, nursing facilities and educational institutions, urgent questions are being asked about the ethics of encouraging people to have feelings towards social robots that have roles as companions, carers and teachers. This article suggests that the quality of these debates is enhanced by examining how people perceive robots and, in particular, how robots’ expressive characteristics stimulate feelings through engaging the embodied imagination. I discuss the perception and expression of the zoomorphic therapeutic robot Paro, before considering the directions an understanding of these processes can take discussions about the aesthetics and ethics of social robots.

  12. War Against the Imagination: Technology, Kids, and Autonomy

    Directory of Open Access Journals (Sweden)

    Anonymous

    2007-07-01

    Full Text Available All children's movies produced, marketed and distributed by corporations are carefully designed sales delivery systems. They exist to sell. Secondarily, but of no less importance, they transmit ideology: even the most banal animated features transmit the social values and expectations of dominant culture. War Against the Imagination begins to develop a critical understanding of how the growing technological sophistication of story-telling media is changing both what and how stories teach young children. How are the boundaries between fantasy and reality disintegrating in the digital age, and of what impact on the lives of kids growing in our communities?

  13. The Effect of Drama on the Creative Imagination of Children in Different Age Groups

    OpenAIRE

    GÜNDOĞAN, AYSUN; ARI, MEZİYET; GÖNEN, MÜBECCEL

    2013-01-01

    Imagination is necessary for creative ideas to emerge. The creative imagination can be developed by suitable education programs especially by drama programs with suitable activities. This article presents findings on whether the effect of drama on the creative imagination of children in different age groups differentiate or not. The experiment group of this research is comprised of 60 children (30 from the age group of 10, 30 from the age group of 13) from a regular primary school and the con...

  14. Improvement of Freezing of Gait in Patients with Parkinson's Disease by Imagining Bicycling

    Directory of Open Access Journals (Sweden)

    Akio Kikuchi

    2014-03-01

    Full Text Available Freezing of gait (FOG is one of the factors that reduce the quality of life in patients with Parkinson's disease (PD. Imagining bicycling before gait start provided improvement in FOG in 2 PD patients. Imagining and mimicking bicycling after the initiation of gait allowed the rhythmic gait to continue without interruption. We suggest that imagining and mimicking bicycling, which are nonexternal cues, could serve as a helpful therapeutic approach for the intractable freezing and interruption of gait of PD patients.

  15. PET/CT in malignant melanoma: contrast-enhanced CT versus plain low-dose CT

    International Nuclear Information System (INIS)

    Pfluger, Thomas; Schneider, Vera; Fougere, Christian la; Bartenstein, Peter; Weiss, Mayo; Melzer, Henriette Ingrid; Coppenrath, Eva; Berking, Carola

    2011-01-01

    The aim of this study was to evaluate the diagnostic value of contrast-enhanced CT (CECT) versus non-enhanced low-dose CT (NECT) in the staging of advanced malignant melanoma with 18 F-fluordeoxyglucose (FDG) positron emission tomography (PET)/CT. In total, 50 18 F-FDG PET/CT examinations were performed in 50 patients with metastasized melanoma. For attenuation correction, whole-body NECT was performed followed by diagnostic CECT with contrast agent. For the whole-body PET, 18 F-FDG was applied. Criteria for evaluation were signs of vital tumour tissue (extent of lesions, contrast enhancement, maximum standardized uptake value >2.5). Findings suspicious for melanoma were considered lesions. NECT, CECT and 18 F-FDG PET were evaluated separately, followed by combined analysis of PET/NECT and PET/CECT. Findings were verified histologically and/or by follow-up (>6 months). Overall, 232 lesions were analysed, and 151 proved to be metastases. The sensitivity of NECT, CECT, PET, PET/NECT and PET/CECT was 62, 85, 90, 97 and 100%, and specificity was 52, 63, 88, 93 and 93%, respectively. Compared to CECT, NECT obtained additional false-negative results: lymph node (n = 19) and liver/spleen metastases (n = 9). Misinterpreted physiological structures mainly caused additional false-positive findings (n = 17). In combined analysis of PET/NECT, six false-positive [other tumours (n = 2), inflammatory lymph nodes (n = 2), inflammatory lung lesion (n = 1), blood vessel (n = 1)] and five false-negative findings [liver (n = 3), spleen (n = 1), lymph node metastases (n = 1)] remained. On PET/CECT, six false-positive [inflammatory lymph nodes (n = 3), other tumours (n = 2), inflammatory lung lesion (n = 1)] and no false-negative findings occurred. However, additional false findings on PET/NECT (6 of 232) did not change staging compared to PET/CECT. Our results indicate that it is justified to perform PET/NECT instead of PET/CECT for melanoma staging. (orig.)

  16. Let's not, and say we would: imagined and actual responses to witnessing homophobia.

    Science.gov (United States)

    Crosby, Jennifer Randall; Wilson, Johannes

    2015-01-01

    We compared imagined versus actual affective and behavioral responses to witnessing a homophobic slur. Participants (N = 72) witnessed a confederate using a homophobic slur, imagined the same scenario, or were not exposed to the slur. Those who imagined hearing the slur reported significantly higher levels of negative affect than those who actually witnessed the slur, and nearly one half of them reported that they would confront the slur, whereas no participants who actually heard the slur confronted it. These findings reveal a discrepancy between imagined and real responses to homophobic remarks, and they have implications for the likelihood that heterosexuals will actually confront homophobic remarks.

  17. Layers Of Visual Imagination And Degrees Of Subjectivity In Listening Experiences Exploring Visual Imagination In Acousmatic Composition And Listening

    Directory of Open Access Journals (Sweden)

    Stefano Poillucci

    2015-08-01

    Full Text Available Abstract Electroacoustic music especially Acousmatic is often perceived differently between listeners and a wide variety of visual images is evoked. This because of the spectromorphological qualities and the abstract reality in which this kind of music carries the listener into. In everyday life it seems that we have a natural tendency to assess and understand reality around us and to quantise how and if the perceived circumstances could affect our wellbeing. Some studies also affirm that brain and the biological function of the sensory and perceptual processes are commonly identical in each listener. This gives evidence that arises the interest to investigate which variations the subjectivity of visual imagery depends on and if it is possible to unfold it in various layers. This experimental research has taken in consideration questionnaire-based listening tests to gather details from each listening experience and to get a better understanding of the visual imagery evoked by electroacoustic compositions into the listeners mind and its degrees of objectivity and subjectivity. The compositions used in the experiment were both composed by the author with the intention of guiding listeners into their personal perceptual-imaginative journey by delivering encoded perhaps objective sonic cues. This paper is a theoretical inter-disciplinary analysis backed by research on the foundations of senses perception cognition emotions etc. An artistic approach based on scientific evidences led to the theorization of layers of imagination and their bias to produce visual images with a degree of subjectivity that lies into micro aspects of sounds and in the perceptual and innate knowledge of each individual. Glossary The terms listed here have been invented or readapted for the purpose of the study in order to make concepts easier to assimilate and understand. Aural World sonic world with intrinsic features Smalley 1997. The purely auditory realm which an

  18. Gamma camera based FDG PET in oncology

    International Nuclear Information System (INIS)

    Park, C. H.

    2002-01-01

    Positron Emission Tomography(PET) was introduced as a research tool in the 1970s and it took about 20 years before PET became an useful clinical imaging modality. In the USA, insurance coverage for PET procedures in the 1990s was the turning point, I believe, for this progress. Initially PET was used in neurology but recently more than 80% of PET procedures are in oncological applications. I firmly believe, in the 21st century, one can not manage cancer patients properly without PET and PET is very important medical imaging modality in basic and clinical sciences. PET is grouped into 2 categories; conventional (c) and gamma camera based ( CB ) PET. CB PET is more readily available utilizing dual-head gamma cameras and commercially available FDG to many medical centers at low cost to patients. In fact there are more CB PET in operation than cPET in the USA. CB PET is inferior to cPET in its performance but clinical studies in oncology is feasible without expensive infrastructures such as staffing, rooms and equipments. At Ajou university Hospital, CBPET was installed in late 1997 for the first time in Korea as well as in Asia and the system has been used successfully and effectively in oncological applications. Our was the fourth PET operation in Korea and I believe this may have been instrumental for other institutions got interested in clinical PET. The following is a brief description of our clinical experience of FDG CBPET in oncology

  19. Bench to bedside molecular functional imaging in translational cancer medicine: to image or to imagine?

    International Nuclear Information System (INIS)

    Mahajan, A.; Goh, V.; Basu, S.; Vaish, R.; Weeks, A.J.; Thakur, M.H.; Cook, G.J.

    2015-01-01

    Ongoing research on malignant and normal cell biology has substantially enhanced the understanding of the biology of cancer and carcinogenesis. This has led to the development of methods to image the evolution of cancer, target specific biological molecules, and study the anti-tumour effects of novel therapeutic agents. At the same time, there has been a paradigm shift in the field of oncological imaging from purely structural or functional imaging to combined multimodal structure–function approaches that enable the assessment of malignancy from all aspects (including molecular and functional level) in a single examination. The evolving molecular functional imaging using specific molecular targets (especially with combined positron-emission tomography [PET] computed tomography [CT] using 2- [ 18 F]-fluoro-2-deoxy-D-glucose [FDG] and other novel PET tracers) has great potential in translational research, giving specific quantitative information with regard to tumour activity, and has been of pivotal importance in diagnoses and therapy tailoring. Furthermore, molecular functional imaging has taken a key place in the present era of translational cancer research, producing an important tool to study and evolve newer receptor-targeted therapies, gene therapies, and in cancer stem cell research, which could form the basis to translate these agents into clinical practice, popularly termed “theranostics”. Targeted molecular imaging needs to be developed in close association with biotechnology, information technology, and basic translational scientists for its best utility. This article reviews the current role of molecular functional imaging as one of the main pillars of translational research. -- Highlights: •Molecular functional imaging (MFI) gives insight into the tumor biology and intratumoral heterogeneity. •It has potential role in identifying radiomic signatures associated with underlying gene-expression. •Radiomics can be used to create a road map

  20. Development of an Anthropomorphic Breast Phantom for Combined PET, B-Mode Ultrasound and Elastographic Imaging

    Science.gov (United States)

    Dang, Jun; Frisch, Benjamin; Lasaygues, Philippe; Zhang, Dachun; Tavernier, Stefaan; Felix, Nicolas; Lecoq, Paul; Auffray, Etiennette; Varela, Joao; Mensah, Serge; Wan, Mingxi

    2011-06-01

    Combining the advantages of different imaging modalities leads to improved clinical results. For example, ultrasound provides good real-time structural information without any radiation and PET provides sensitive functional information. For the ongoing ClearPEM-Sonic project combining ultrasound and PET for breast imaging, we developed a dual-modality PET/Ultrasound (US) phantom. The phantom reproduces the acoustic and elastic properties of human breast tissue and allows labeling the different tissues in the phantom with different concentrations of FDG. The phantom was imaged with a whole-body PET/CT and with the Supersonic Imagine Aixplorer system. This system allows both B-mode US and shear wave elastographic imaging. US elastography is a new imaging method for displaying the tissue elasticity distribution. It was shown to be useful in breast imaging. We also tested the phantom with static elastography. A 6D magnetic positioning system allows fusing the images obtained with the two modalities. ClearPEM-Sonic is a project of the Crystal Clear Collaboration and the European Centre for Research on Medical Imaging (CERIMED).

  1. Development of an Anthropomorphic Breast Phantom for Combined PET, B-Mode Ultrasound and Elastographic Imaging

    CERN Document Server

    Dang, J; Tavernier, S; Lasaygues, P; Mensah, S; Zhang, D C; Auffray, E; Frisch, B; Varela, J; Wan, M X; Felix, N

    2011-01-01

    Combining the advantages of different imaging modalities leads to improved clinical results. For example, ultrasound provides good real-time structural information without any radiation and PET provides sensitive functional information. For the ongoing ClearPEM-Sonic project combining ultrasound and PET for breast imaging, we developed a dual-modality PET/Ultrasound (US) phantom. The phantom reproduces the acoustic and elastic properties of human breast tissue and allows labeling the different tissues in the phantom with different concentrations of FDG. The phantom was imaged with a whole-body PET/CT and with the Supersonic Imagine Aixplorer system. This system allows both B-mode US and shear wave elastographic imaging. US elastography is a new imaging method for displaying the tissue elasticity distribution. It was shown to be useful in breast imaging. We also tested the phantom with static elastography. A 6D magnetic positioning system allows fusing the images obtained with the two modalities. ClearPEM-Soni...

  2. Neuropsychiatry: PET and SPECT

    International Nuclear Information System (INIS)

    Quintana F, Juan Carlos

    2002-01-01

    Functional brain imaging with PET and SPECT have a definitive and well established role in the investigation of a variety of conditions such as dementia, epilepsy and drug addiction. With these methods it is possible to detect early rCBF (regional Cerebral Blood Flow) changes seen in dementia (even before clinical symptoms) and differentiate Alzheimer's disease from other dementias by means of the rCBF pattern change. 18-F-FDG PET imaging is a useful tool in partial epilepsy because both rCBF and brain metabolism are compromised at the epileptogenic focus. During the seizure, rCBF dramatically increases locally. Using SPECT it is possible to locate such foci with 97% accuracy. In drug addiction, particularly with cocaine, functional imaging has proven to be very sensitive to detect brain flow and metabolism derangement early in the course of this condition. These findings are important in many ways: prognostic value, they are used as a powerful reinforcement tool and to monitor functional recovery with rehabilitation. There are many other conditions in which functional brain imaging is of importance such as acute stroke treatment assessment, trauma rehabilitation and in psychiatric and abnormal movement diseases specially with the development of receptor imaging (au)

  3. FDG PET imaging dementia

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Byeong Cheol [Kyungpook National University Medical School and Kyungpook National University Hospital, Daegu (Korea, Republic of)

    2007-04-15

    Dementia is a major burden for many countries including South Korea, where life expectancy is continuously growing and the proportion of aged people is rapidly growing. Neurodegenerative disorders, such as, Alzheimer disease, dementia with Lewy bodies, frontotemporal dementia. Parkinson disease, progressive supranuclear palsy, corticobasal degeneration, Huntington disease, can cause dementia, and cerebrovascular disease also can cause dementia. Depression or hypothyroidism also can cause cognitive deficits, but they are reversible by management of underlying cause unlike the forementioned dementias. Therefore these are called pseudodementia. We are entering an era of dementia care that will be based upon the identification of potentially modifiable risk factors and early disease markers, and the application of new drugs postpone progression of dementias or target specific proteins that cause dementia. Efficient pharmacologic treatment of dementia needs not only to distinguish underlying causes of dementia but also to be installed as soon as possible. Therefore, differential diagnosis and early diagnosis of dementia are utmost importance. F-18 FDG PET is useful for clarifying dementing diseases and is also useful for early detection of the disease. Purpose of this article is to review the current value of FDG PET for dementing diseases including differential diagnosis of dementia and prediction of evolving dementia.

  4. FDG PET imaging dementia

    International Nuclear Information System (INIS)

    Ahn, Byeong Cheol

    2007-01-01

    Dementia is a major burden for many countries including South Korea, where life expectancy is continuously growing and the proportion of aged people is rapidly growing. Neurodegenerative disorders, such as, Alzheimer disease, dementia with Lewy bodies, frontotemporal dementia. Parkinson disease, progressive supranuclear palsy, corticobasal degeneration, Huntington disease, can cause dementia, and cerebrovascular disease also can cause dementia. Depression or hypothyroidism also can cause cognitive deficits, but they are reversible by management of underlying cause unlike the forementioned dementias. Therefore these are called pseudodementia. We are entering an era of dementia care that will be based upon the identification of potentially modifiable risk factors and early disease markers, and the application of new drugs postpone progression of dementias or target specific proteins that cause dementia. Efficient pharmacologic treatment of dementia needs not only to distinguish underlying causes of dementia but also to be installed as soon as possible. Therefore, differential diagnosis and early diagnosis of dementia are utmost importance. F-18 FDG PET is useful for clarifying dementing diseases and is also useful for early detection of the disease. Purpose of this article is to review the current value of FDG PET for dementing diseases including differential diagnosis of dementia and prediction of evolving dementia

  5. L’imagination et les biais de l’empathie

    Directory of Open Access Journals (Sweden)

    Morgane Paris

    2010-05-01

    Full Text Available Empathy is an emotional mode associating the point of view of other people to physiological sensations. This phenomena tends to be more significant with certain people than others. And yet, there are sometimes good moral reasons to promote a more egalitarian empathy. Our hypo- thesis of moral psychology is that it is possible to use imagination – and in particular its volon- tary dimension and its openness to emotions – to modify certain empathic biaises.RÉSUMÉL'empathie est un mode émotionnel qui associe le point de vue d'autrui à des sensations phy- siologiques. Ce phénomène a tendance à être plus important envers certaines personnes qu'en- vers d'autres. Or, il existe parfois de bonnes raisons morales de promouvoir une empathie plus égalitaire. Notre hypothèse de psychologie morale est qu'il est possible d'utiliser l'imagination, et en particulier sa dimension volontaire et sa transparence aux émotions, pour corriger certains biais empathiques.

  6. Imagine the Feeling: An Aesthetic Science of Psychology.

    Science.gov (United States)

    Quigua, Fernando; Clegg, Joshua W

    2015-09-01

    We claim that static trait models have dominated contemporary personality psychology but fail to reflect adequately the persons they depict. Beginning from, but moving well beyond, this critique of the five factor model (and the personality psychology field over which it reigns), we shine an aesthetic and critical light on psychology's wider failings. We review the linguistic and methodological features that have undermined the discipline's faithful understandings of human beings and their experience. In its place, we champion an aesthetic (as opposed to an an-esthetic) science of the person, one that is responsive in spirit and in practice to the emotional and imaginative life of participants and to the contexts in which they move. Specifically, we suggest that the images of fantasy and of ordinary metaphor may afford poetic understandings of participant experience that surpass those produced by literal, discursive description. We also hold that these images may offer us the most sensitive and faithful expressions of how social and environmental contexts-and so-called structural and discursive realities-are felt. The paper concludes by sketching several methodological trajectories that may stimulate researcher imagination and empathy, making research more faithful to participants and the reaches of their experience. Research practices informed by feeling and image in this way may generate new knowledge as well as new obligations.

  7. 'Imagined guilt' vs 'recollected guilt': implications for fMRI.

    Science.gov (United States)

    Mclatchie, Neil; Giner-Sorolla, Roger; Derbyshire, Stuart W G

    2016-05-01

    Guilt is thought to maintain social harmony by motivating reparation. This study compared two methodologies commonly used to identify the neural correlates of guilt. The first, imagined guilt, requires participants to read hypothetical scenarios and then imagine themselves as the protagonist. The second, recollected guilt, requires participants to reflect on times they personally experienced guilt. In the fMRI scanner, participants were presented with guilt/neutral memories and guilt/neutral hypothetical scenarios. Contrasts confirmed a priori predictions that guilt memories, relative to guilt scenarios, were associated with significantly greater activity in regions associated with affect [anterior cingulate cortex (ACC), Caudate, Insula, orbital frontal cortex (OFC)] and social cognition [temporal pole (TP), precuneus). Similarly, results indicated that guilt memories, relative to neutral memories, were also associated with greater activity in affective (ACC, amygdala, Insula, OFC) and social cognition (mPFC, TP, precuneus, temporo-parietal junction) regions. There were no significant differences between guilt hypothetical scenarios and neutral hypothetical scenarios in either affective or social cognition regions. The importance of distinguishing between different guilt inductions inside the scanner is discussed. We offer explanations of our results and discuss ideas for future research. © The Author (2016). Published by Oxford University Press.

  8. Pet ownership and physical health.

    Science.gov (United States)

    Matchock, Robert L

    2015-09-01

    Pet ownership and brief human-animal interactions can serve as a form of social support and convey a host of beneficial psychological and physiological health benefits. This article critically examines recent relevant literature on the pet-health connection. Cross-sectional studies indicate correlations between pet ownership and numerous aspects of positive health outcomes, including improvements on cardiovascular measures and decreases in loneliness. Quasi-experimental studies and better controlled experimental studies corroborate these associations and suggest that owning and/or interacting with a pet may be causally related to some positive health outcomes. The value of pet ownership and animal-assisted therapy (AAT), as a nonpharmacological treatment modality, augmentation to traditional treatment, and healthy preventive behavior (in the case of pet ownership), is starting to be realized. However, more investigations that employ randomized controlled trials with larger sample sizes and investigations that more closely examine the underlying mechanism of the pet-health effect, such as oxytocin, are needed.

  9. New developments in PET detector technology

    International Nuclear Information System (INIS)

    Niu Lingxin; Zhao Shujun; Zhang Bin; Liu Haojia

    2010-01-01

    The researches on PET detector are always active and innovative area. The research direction of PET detector includes improving performances of scintillator-based detectors, investigating new detectors suitable for multi-modality imaging (e.g. PET/CT and PET/MRI), meeting requirements of TOF and DOI technologies and boosting the development of the technologies. In this paper, new developments in PET detector technology about scintillation crystal, photodetector and semiconductor detector is introduced. (authors)

  10. Imagination persistence on the vertical axis of Khaghani's odes, a personal style

    Directory of Open Access Journals (Sweden)

    Seyed Javadi Mortezayi

    2016-05-01

    Full Text Available AbstractKhaghani is one of the preeminent Persian poets. He is a stylist poet. Creating exquisite, dramatic and enigmatic imaginations in the era that most of the poets tried to imitate, integrate and repeat the themes of predecessors makes his position in the poetry more clear. His poems inspired by his rich talent and his proficiency in various sciences such as medicine, astronomy, philosophy, theology, history and math are one of the most exquisite and beautiful Persian poetries.Understanding his poems seems to be difficult due to his heavy use of these sciences, as well as using specialized and strange wordings and creating out of the mind imaginations.This Shervani poet not only has created so beautiful and exquisite dramatic themes and imaginations on the horizontal axis, but also he has done same in several cases on the vertical axis of the poem. In cases the themes are felt repeated, he has uttered them masterfully and skillfully with so novel and exquisite imaginations that they are not seem repeated and keep their value. One of the most outstanding characteristics of Khaghani's personal style is imagination persistence on vertical axis of the odes.Imagination on two horizontal and vertical axes of the poet usually includes the terms such as congestion, interference and persistence. The congestion of imagination mostly takes place on the horizontal axis of the poem and resulted by involving several independence imaginations in a verse of the poem and usually leads to compression of imaginations and their interference and disparity.Poets often use congestion to demonstrate their talent and power in Poetry, while in most of the cases it has no result except for imaginations' interference and that it causes some problems for reader to reach what poet means. But, persistence means to bring several imaginations about an object, a word or a motive in several verses which indicate the talent and imagining power of the poet and his emotional

  11. Detection of preclinical Parkinson's disease with PET

    International Nuclear Information System (INIS)

    Brooks, D.J.

    1991-01-01

    Putamen 18F-dopa uptake of patients with Parkinson's disease (PD) is reduced by at least 35% at onset of symptoms; therefore, positron-emission tomography (PET) can be used to detect preclinical disease in clinically unaffected twins and relatives of patients with PD. Three out of 6 monozygotic and 2 out of 3 dizygotic unaffected PD co-twins have shown reduced putamen 18F-dopa uptake to date. In addition, an intact sibling and a daughter of 1 of 4 siblings with PD both had low putamen 18F-dopa uptake. These preliminary findings suggest there may be a familial component to the etiology of PD. PET can also be used to detect underlying nigral pathology in patients with isolated tremor and patients who become rigid taking dopamine-receptor blocking agents (DRBAs). Patients with familial essential tremor have normal, and those with isolated rest tremor have consistently low, putamen 18F-dopa uptake. Drug-induced parkinsonism is infrequently associated with underlying nigral pathology

  12. PET and PET/CT in tumour of undetermined origin

    International Nuclear Information System (INIS)

    Garcia O, J.R.

    2007-01-01

    In this presentation the following conclusions were obtained regarding the use of PET and PET/CT in patient with cancer of unknown primary: 1. Detection of the primary one in 1/3 at 1/2 of patient. 2. It detects metastases in other places in 50%. 3. It changes the initial therapy planned in 1/3 at 1/2 of patient. 4. Useful in initial phases of protocol study to limit the other procedures. After standard evaluation. Before advanced protocol. 5. PET/CT study increases the % of primary detection, although in a non significant way vs. PET. 6. They are required more studies to value their utility to a more objective manner. (Author)

  13. PET/TAC in Oncology; PET/TAC en Oncologia

    Energy Technology Data Exchange (ETDEWEB)

    Jimenez V, A M [Especialista en Medicina Nuclear, Profa. Depto. Radiologia de la Facultad de Medicina, Universidad Complutense de Madrid, Madrid (Spain)

    2007-07-01

    From this presentation of PET-TAC in oncology the following advantages on the conventional PET are obtained: 1. More short study and stadium in one session. 2. It adds the information of both techniques. 3. Better localization of leisure: affected organ, stadium change (neck, mediastinum, abdomen). 4. Reduction of false positive (muscle, brown fat, atelectasis, pneumonias, intestine, urinary vials, etc.). 5. Reduction of negative false. 6. Reduction of not conclusive. 7. More understandable for other specialists. 8. Biopsies guide. 9. Planning radiotherapy.

  14. Application of cross-species PET imaging to assess neurotransmitter release in brain.

    Science.gov (United States)

    Finnema, Sjoerd J; Scheinin, Mika; Shahid, Mohammed; Lehto, Jussi; Borroni, Edilio; Bang-Andersen, Benny; Sallinen, Jukka; Wong, Erik; Farde, Lars; Halldin, Christer; Grimwood, Sarah

    2015-11-01

    This review attempts to summarize the current status in relation to the use of positron emission tomography (PET) imaging in the assessment of synaptic concentrations of endogenous mediators in the living brain. Although PET radioligands are now available for more than 40 CNS targets, at the initiation of the Innovative Medicines Initiative (IMI) "Novel Methods leading to New Medications in Depression and Schizophrenia" (NEWMEDS) in 2009, PET radioligands sensitive to an endogenous neurotransmitter were only validated for dopamine. NEWMEDS work-package 5, "Cross-species and neurochemical imaging (PET) methods for drug discovery", commenced with a focus on developing methods enabling assessment of changes in extracellular concentrations of serotonin and noradrenaline in the brain. Sharing the workload across institutions, we utilized in vitro techniques with cells and tissues, in vivo receptor binding and microdialysis techniques in rodents, and in vivo PET imaging in non-human primates and humans. Here, we discuss these efforts and review other recently published reports on the use of radioligands to assess changes in endogenous levels of dopamine, serotonin, noradrenaline, γ-aminobutyric acid, glutamate, acetylcholine, and opioid peptides. The emphasis is on assessment of the availability of appropriate translational tools (PET radioligands, pharmacological challenge agents) and on studies in non-human primates and human subjects, as well as current challenges and future directions. PET imaging directed at investigating changes in endogenous neurochemicals, including the work done in NEWMEDS, have highlighted an opportunity to further extend the capability and application of this technology in drug development.

  15. The Beat Goes on: Rhythmic Modulation of Cortical Potentials by Imagined Tapping

    Science.gov (United States)

    Osman, Allen; Albert, Robert; Ridderinkhof, K. Richard; Band, Guido; van der Molen, Maurits

    2006-01-01

    A frequency analysis was used to tag cortical activity from imagined rhythmic movements. Participants synchronized overt and imagined taps with brief visual stimuli presented at a constant rate, alternating between left and right index fingers. Brain potentials were recorded from across the scalp and topographic maps made of their power at the…

  16. Self-imagining enhances recognition memory in memory-impaired individuals with neurological damage.

    Science.gov (United States)

    Grilli, Matthew D; Glisky, Elizabeth L

    2010-11-01

    The ability to imagine an elaborative event from a personal perspective relies on several cognitive processes that may potentially enhance subsequent memory for the event, including visual imagery, semantic elaboration, emotional processing, and self-referential processing. In an effort to find a novel strategy for enhancing memory in memory-impaired individuals with neurological damage, we investigated the mnemonic benefit of a method we refer to as self-imagining-the imagining of an event from a realistic, personal perspective. Fourteen individuals with neurologically based memory deficits and 14 healthy control participants intentionally encoded neutral and emotional sentences under three instructions: structural-baseline processing, semantic processing, and self-imagining. Findings revealed a robust "self-imagination effect (SIE)," as self-imagination enhanced recognition memory relative to deep semantic elaboration in both memory-impaired individuals, F(1, 13) = 32.11, p memory disorder nor were they related to self-reported vividness of visual imagery, semantic processing, or emotional content of the materials. The findings suggest that the SIE may depend on unique mnemonic mechanisms possibly related to self-referential processing and that imagining an event from a personal perspective makes that event particularly memorable even for those individuals with severe memory deficits. Self-imagining may thus provide an effective rehabilitation strategy for individuals with memory impairment.

  17. Development of the Correspondence between Real and Imagined Fine and Gross Motor Actions

    Science.gov (United States)

    Sachet, Alison B.; Frey, Scott H.; Jacobs, Stéphane; Taylor, Marjorie

    2016-01-01

    The development of the correspondence between real and imagined motor actions was investigated in 2 experiments. Experiment 1 evaluated whether children imagine body position judgments of fine motor actions in the same way as they perform them. Thirty-two 8-year-old children completed a task in which an object was presented in different…

  18. Significance and role of imagination in the life of modern person

    OpenAIRE

    Ирина Аркадиевна Кадиевская

    2016-01-01

    In the article it is proved that the formation of gloomy morbid imagination is dangerous to human life and health, while the development of a positive optimistic creative imagination contrary is justified and useful. Results in this direction have shown methods like autogenic training (AT), biofeedback (BFB), meditation, psychomuscular, ideamotor, visuomotor training etc.

  19. Imagined Positive Emotions and Inhibitory Control: The Differentiated Effect of Pride versus Happiness

    Science.gov (United States)

    Katzir, Maayan; Eyal, Tal; Meiran, Nachshon; Kessler, Yoav

    2010-01-01

    "Inhibitory control" is a cognitive mechanism that contributes to successful self-control (i.e., adherence to a long-term goal in the face of an interfering short-term goal). This research explored the effect of imagined positive emotional events on inhibition. The authors proposed that the influence of imagined emotions on inhibition…

  20. Writings of Healing and Resistance: Empathy and the Imagination-Intellect. Culture Critique. Volume 7

    Science.gov (United States)

    Weems, Mary E., Ed.

    2013-01-01

    "Writings of Healing and Resistance: Empathy and the Imagination-Intellect" is a multi-authored, interdisciplinary journey. It continues the work started in Public Education and the Imagination-Intellect (Peter Lang, 2003) by extending the importance of empathy in developing an action-based social consciousness. Mary E. Weems doesn't argue for a…

  1. The Effects of Spatial Contextual Familiarity on Remembered Scenes, Episodic Memories, and Imagined Future Events

    Science.gov (United States)

    Robin, Jessica; Moscovitch, Morris

    2014-01-01

    Several recent studies have explored the effect of contextual familiarity on remembered and imagined events. The aim of this study was to examine the extent of this effect by comparing the effect of cuing spatial memories, episodic memories, and imagined future events with spatial contextual cues of varying levels of familiarity. We used…

  2. Moving off the Page: Tapping into Young Children's Imagination

    Science.gov (United States)

    Miranda, Martina

    2015-01-01

    This article explores the interplay between young children's spontaneous engagement in learning through their imagination, and the mind-set of the teacher when approaching planning for instruction. Perhaps by connecting with our own imaginative thinking, we can gain insights about our young learners, and find additional strategies to promote…

  3. Flooding in imagination vs flooding in vivo: A comparison with agoraphobics

    NARCIS (Netherlands)

    Emmelkamp, Paul M.G.; Wessels, Hemmy

    In this investigation of agoraphobic patients, 3 different flooding procedures were compared: (1) prolonged exposure in vivo, (2) flooding in the imagination by a ‘live’ therapist and (3) a combination of flooding in the imagination and flooding in vivo. After an intermediate-test all clients were

  4. Differential Effects of Personality Traits and Environmental Predictors on Reproductive and Creative Imagination

    Science.gov (United States)

    Liang, Chaoyun; Chang, Chi-Cheng; Hsu, Yuling

    2014-01-01

    The purpose of this study was twofold: (1) to analyze the effects of both personality and environmental variables on the imagination of video/film major university students; and (2) to test the mediator effect resulting from the variable of social climate. The results of this study supported both indicators of imaginative capabilities and…

  5. Significance and role of imagination in the life of modern person

    Directory of Open Access Journals (Sweden)

    Ирина Аркадиевна Кадиевская

    2016-03-01

    Full Text Available In the article it is proved that the formation of gloomy morbid imagination is dangerous to human life and health, while the development of a positive optimistic creative imagination contrary is justified and useful. Results in this direction have shown methods like autogenic training (AT, biofeedback (BFB, meditation, psychomuscular, ideamotor, visuomotor training etc.

  6. Temporal characteristics of imagined and actual walking in frail older adults.

    Science.gov (United States)

    Nakano, Hideki; Murata, Shin; Shiraiwa, Kayoko; Iwase, Hiroaki; Kodama, Takayuki

    2018-05-09

    Mental chronometry, commonly used to evaluate motor imagery ability, measures the imagined time required for movements. Previous studies investigating mental chronometry of walking have investigated healthy older adults. However, mental chronometry in frail older adults has not yet been clarified. To investigate temporal characteristics of imagined and actual walking in frail older adults. We investigated the time required for imagined and actual walking along three walkways of different widths [width(s): 50, 25, 15 cm × length: 5 m] in 29 frail older adults and 20 young adults. Imagined walking was measured with mental chronometry. We observed significantly longer imagined and actual walking times along walkways of 50, 25, and 15 cm width in frail older adults compared with young adults. Moreover, temporal differences (absolute error) between imagined and actual walking were significantly greater in frail older adults than in young adults along walkways with a width of 25 and 15 cm. Furthermore, we observed significant differences in temporal differences (constant error) between frail older adults and young adults for walkways with a width of 25 and 15 cm. Frail older adults tended to underestimate actual walking time in imagined walking trials. Our results suggest that walkways of different widths may be a useful tool to evaluate age-related changes in imagined and actual walking in frail older adults.

  7. Cultivating the Ethical Imagination in Education: Perspectives from Three Public Intellectuals

    Science.gov (United States)

    Spector, Hannah

    2017-01-01

    Because the subject of imagination is both complex and can be conceived of in different ways, the focus of the first part of this article is to engage in a descriptive analysis of this faculty. With the help of Greene's intellectual predecessor and former teacher Hannah Arendt, Hannah Spector draws distinctions between imagination and other…

  8. The Place of Imagination in Inclusive Pedagogy: Thinking with Maxine Greene and Hannah Arendt

    Science.gov (United States)

    Harwood, Valerie

    2010-01-01

    Conceptualising difference is a key task for inclusive pedagogy, and vital to the politics of inclusion. My purpose in this paper is to consider the place that imagination has in helping us to conceptualise difference, and to argue that imagination has a key part to play in inclusive pedagogy. To do this I draw closely on the work of Maxine Greene…

  9. Dissociative Experiences, Creative Imagination, and Artistic Production in Students of Fine Arts

    Science.gov (United States)

    Perez-Fabello, Maria Jose; Campos, Alfredo

    2011-01-01

    The current research was designed to assess the influence of dissociative experiences and creative imagination on the artistic production of Fine Arts students of the University of Vigo (Spain). The sample consisted of 81 students who were administered the Creative Imagination Scale and The Dissociative Experiences Scale. To measure artistic…

  10. The Role of Radical Imagination in Social Work Education, Practice, and Research

    Science.gov (United States)

    Barnetz, Zion

    2015-01-01

    This article addresses the role of imagination in social work education, practice, and research. Following a brief discussion of terms, the author attempts to identify the various contributions of human imagination to social change processes. The second part presents the argument that the cultural structure known as Social Darwinism significantly…

  11. Towards a Pedagogy of Imagination: A Phenomenological Case Study of Holistic Education

    Science.gov (United States)

    Nielsen, Thomas William

    2006-01-01

    This article offers a synthesis of my recently completed doctorate study of Rudolf Steiner's notion of imaginative teaching. Seven original imaginative teaching methods (drama, exploration, storytelling, routine, arts, discussion and empathy) are introduced via phenomenological moments, followed by analysis and discussion. The article concludes…

  12. Bacteriophage cocktail for biocontrol of Salmonella in dried pet food.

    Science.gov (United States)

    Heyse, Serena; Hanna, Leigh Farris; Woolston, Joelle; Sulakvelidze, Alexander; Charbonneau, Duane

    2015-01-01

    Human salmonellosis has been associated with contaminated pet foods and treats. Therefore, there is interest in identifying novel approaches for reducing the risk of Salmonella contamination within pet food manufacturing environments. The use of lytic bacteriophages shows promise as a safe and effective way to mitigate Salmonella contamination in various food products. Bacteriophages are safe, natural, highly targeted antibacterial agents that specifically kill bacteria and can be targeted to kill food pathogens without affecting other microbiota. In this study, we show that a cocktail containing six bacteriophages had a broadspectrum activity in vitro against a library of 930 Salmonella enterica strains representing 44 known serovars. The cocktail was effective against 95% of the strains in this tested library. In liquid culture dose-ranging experiments, bacteriophage cocktail concentrations of ≥10(8) PFU/ml inactivated more than 90% of the Salmonella population (10(1) to 10(3) CFU/ml). Dried pet food inoculated with a mixture containing equal proportions of Salmonella serovars Enteritidis (ATCC 4931), Montevideo (ATCC 8387), Senftenberg (ATCC 8400), and Typhimurium (ATCC 13311) and then surface treated with the six-bacteriophage cocktail (≥2.5 ± 1.5 × 10(6) PFU/g) achieved a greater than 1-log (P contamination in samples taken from an undistributed lot of commercial dried dog food that tested positive for Salmonella. Our results indicate that bacteriophage biocontrol of S. enterica in dried pet food is technically feasible.

  13. PET and PET/CT in tumour of undetermined origin; PET y PET/CT en tumor de origen indeterminado

    Energy Technology Data Exchange (ETDEWEB)

    Garcia O, J R [Nuclear Medicine and Molecular Imaging, PET/CT, Centro Medico ABC, Mexico D.F. (Mexico)

    2007-07-01

    In this presentation the following conclusions were obtained regarding the use of PET and PET/CT in patient with cancer of unknown primary: 1. Detection of the primary one in 1/3 at 1/2 of patient. 2. It detects metastases in other places in 50%. 3. It changes the initial therapy planned in 1/3 at 1/2 of patient. 4. Useful in initial phases of protocol study to limit the other procedures. After standard evaluation. Before advanced protocol. 5. PET/CT study increases the % of primary detection, although in a non significant way vs. PET. 6. They are required more studies to value their utility to a more objective manner. (Author)

  14. PET imaging for brain function

    International Nuclear Information System (INIS)

    Fukuda, Hiroshi

    2003-01-01

    Described are the principle of PET and its characteristics, imaging of human brain function, mapping of detailed human cerebral functions and PET imaging of nerve transmission. Following compounds labeled by positron emitters are used for PET imaging of brain functions: for blood flow and oxygen metabolism, 15 O-O 2 gas, water and carbon dioxide; for energy metabolism, 18 F-fluorodeoxyglucose; and for nerve transmission functions in receptor binding, transporter, transmitter synthesis and enzyme, 11 C- or 18 F-dopamine, serotonin and their analogues, and acetylcholine analogues. For brain mapping, examples of cognition tasks, results and their statistics are presented with images for blood flow. Nerve transmissions in schizophrenia and Alzheimer disease are imaged with labeled analogues of dopamine and acetylcholine, respectively. PET is becoming more and more important in the field of psychiatric science particularly in the coming society of increasing aged people. (N.I.)

  15. Measuring receptor occupancy with PET

    NARCIS (Netherlands)

    van Waarde, A

    Many physiological and biochemical measurements can be performed noninvasively in humans with modern imaging techniques like magnetic resonance imaging (MRI), positron emission tomography (PET) or single-photon emission computed tomography (SPECT). This review focuses on the monitoring of

  16. Effect of compatibilizer on impact and morphological analysis of recycled HDPE/PET blends

    Energy Technology Data Exchange (ETDEWEB)

    Salleh, Mohd Nazry [School of Applied Physics, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia and School of Materials Engineering, Universiti Malaysia Perlis, 02600 Jejawi, Perlis (Malaysia); Ahmad, Sahrim; Ghani, Mohd Hafizuddin Ab; Chen, Ruey Shan [School of Applied Physics, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor (Malaysia)

    2013-11-27

    Blends based on recycled high density polyethylene (rHDPE) and recycled polyethylene terephthalate (rPET) were prepared using a corotating twin screw extruder. PET and HDPE are incompatible polymers and their blends showed poor properties. Compatibilization is a step to obtain blends with good mechanical properties and in this work, ethylene glycidyl methacrylate copolymer (E-GMA) was used as a compatibilizing agent. The effect of blends based on rHDPE and rPET with and without a compatibilizer, E-GMA were examined. From the studies clearly showed that the addition of 5% E-GMA increased the impact strength. SEM analysis of rHDPE/rPET blends confirmed the morphological interaction and improved interfacial bonding between two phases.

  17. Radiation monitoring of PET staff

    International Nuclear Information System (INIS)

    Trang, A.

    2004-01-01

    Full text: Positron emission tomography (PET) is becoming a common diagnostic tool in hospitals, often located in and employing staff from the Nuclear Medicine or Radiology departments. Although similar in some ways, staff in PET departments are commonly found to have the highest radiation doses in the hospital environment due to unique challenges which PET tracers present in administration as well as production. The establishment of a PET centre with a dedicated cyclotron has raised concerns of radiation protection to the staff at the WA PET Centre and the Radiopharmaceutical Production and Development (RAPID) team. Since every PET centre has differing designs and practices, it was considered important to closely monitor the radiation dose to our staff so that improvements to practices and design could be made to reduce radiation dose. Electronic dosimeters (MGP DMC 2000XB), which have a facility to log time and dose at 10 second intervals, were provided to three PET technologists and three PET nurses. These were worn in the top pocket of their lab coats throughout a whole day. Each staff member was then asked to note down their duties throughout the day and also note the time they performed each duty. The duties would then correlate with the dose with which the electronic monitor recorded and an estimate of radiation dose per duty could be given. Also an estimate of the dose per day to each staff member could be made. PET nurses averaged approximately 20 μ8v per day getting their largest dose from caring for occasional problematic patients. Smaller doses of a 1-2 μ8v were recorded for injections and removing cannulas. PET technologists averaged approximately 15 μ8v per day getting their largest dose of 1-5μ8v mainly from positioning of patients and sometimes larger doses due to problematic patients. Smaller doses of 1-2 μ5v were again recorded for injections and removal of cannulas. Following a presentation given to staff, all WA PET Centre and RAPID staff

  18. Imagining the personal past: Episodic counterfactuals compared to episodic memories and episodic future projections

    DEFF Research Database (Denmark)

    Özbek, Müge; Bohn, Annette; Berntsen, Dorthe

    2017-01-01

    Episodic counterfactuals are imagined events that could have happened, but did not happen, in a person’s past. Such imagined past events are important aspects of mental life, affecting emotions, decisions, and behaviors. However, studies examining their phenomenological characteristics and content...... are few. Here we introduced a new method to systematically compare self-generated episodic counterfactuals to self-generated episodic memories and future projections with regard to their phenomenological characteristics (e.g., imagery, emotional valence, rehearsal) and content (e.g., reference to cultural...... distance. The findings show that imagined events are phenomenologically different from memories of experienced events, consistent with reality monitoring theory, and that imagined future events are different from both actual and imagined past events, consistent with some theories of motivation....

  19. Imagination, Waldorf, and critical literacies: Possibilities for transformative education in mainstream schools

    Directory of Open Access Journals (Sweden)

    Monica Shank

    2016-07-01

    Full Text Available In the face of transmission-oriented national curricula, this study explores possibilities for claiming space for imagination, as ‘the most powerful and energetic of learning tools’ (Egan 1986, in early childhood education in mainstream Kenyan schools. Drawing from Egan’s work on imagination and Cummins’ Nested Pedagogical Orientations framework, this study interrogates the indispensable role of imagination in transformative education, as well as its utility in the ‘transmission’ of the government curriculum. This study draws insights from an initiative integrating imaginative, Waldorf-inspired pedagogies into mainstream pre-primary and early primary classrooms to explore how imagination-based pedagogies, including storytelling, creative play, poems and verses, drawing and painting, can support the development of critical literacies in young children.

  20. [Biological agents].

    Science.gov (United States)

    Amano, Koichi

    2009-03-01

    There are two types of biological agents for the treatment of rheumatoid arthritis (RA); monoclonal antibodies and recombinant proteins. Among the latter, etanercept, a recombinant fusion protein of soluble TNF receptor and IgG was approved in 2005 in Japan. The post-marketing surveillance of 13,894 RA patients revealed the efficacy and safety profiles of etanercept in the Japanese population, as well as overseas studies. Abatacept, a recombinant fusion protein of CTLA4 and IgG, is another biological agent for RA. Two clinical trials disclosed the efficacy of abatacept for difficult-to-treat patients: the AIM for MTX-resistant cases and the ATTAIN for patients who are resistant to anti-TNF. The ATTEST trial suggested abatacept might have more acceptable safety profile than infliximab. These biologics are also promising for the treatment of RA for not only relieving clinical symptoms and signs but retarding structural damage.

  1. PET/TAC in Oncology

    International Nuclear Information System (INIS)

    Jimenez V, A.M.

    2007-01-01

    From this presentation of PET-TAC in oncology the following advantages on the conventional PET are obtained: 1. More short study and stadium in one session. 2. It adds the information of both techniques. 3. Better localization of leisure: affected organ, stadium change (neck, mediastinum, abdomen). 4. Reduction of false positive (muscle, brown fat, atelectasis, pneumonias, intestine, urinary vials, etc.). 5. Reduction of negative false. 6. Reduction of not conclusive. 7. More understandable for other specialists. 8. Biopsies guide. 9. Planning radiotherapy

  2. PET imaging in pediatric oncology

    International Nuclear Information System (INIS)

    Shulkin, B.L.

    2004-01-01

    High-quality PET imaging of pediatric patients is challenging and requires attention to issues commonly encountered in the practice of pediatric nuclear medicine, but uncommon to the imaging of adult patients. These include intravenous access, fasting, sedation, consent, and clearance of activity from the urinary tract. This paper discusses some technical differences involved in pediatric PET to enhance the quality of scans and assure the safety and comfort of pediatric patients. (orig.)

  3. Quantitative PET of liver functions.

    Science.gov (United States)

    Keiding, Susanne; Sørensen, Michael; Frisch, Kim; Gormsen, Lars C; Munk, Ole Lajord

    2018-01-01

    Improved understanding of liver physiology and pathophysiology is urgently needed to assist the choice of new and upcoming therapeutic modalities for patients with liver diseases. In this review, we focus on functional PET of the liver: 1) Dynamic PET with 2-deoxy-2-[ 18 F]fluoro- D -galactose ( 18 F-FDGal) provides quantitative images of the hepatic metabolic clearance K met (mL blood/min/mL liver tissue) of regional and whole-liver hepatic metabolic function. Standard-uptake-value ( SUV ) from a static liver 18 F-FDGal PET/CT scan can replace K met and is currently used clinically. 2) Dynamic liver PET/CT in humans with 11 C-palmitate and with the conjugated bile acid tracer [ N -methyl- 11 C]cholylsarcosine ( 11 C-CSar) can distinguish between individual intrahepatic transport steps in hepatic lipid metabolism and in hepatic transport of bile acid from blood to bile, respectively, showing diagnostic potential for individual patients. 3) Standard compartment analysis of dynamic PET data can lead to physiological inconsistencies, such as a unidirectional hepatic clearance of tracer from blood ( K 1 ; mL blood/min/mL liver tissue) greater than the hepatic blood perfusion. We developed a new microvascular compartment model with more physiology, by including tracer uptake into the hepatocytes from the blood flowing through the sinusoids, backflux from hepatocytes into the sinusoidal blood, and re-uptake along the sinusoidal path. Dynamic PET data include information on liver physiology which cannot be extracted using a standard compartment model. In conclusion , SUV of non-invasive static PET with 18 F-FDGal provides a clinically useful measurement of regional and whole-liver hepatic metabolic function. Secondly, assessment of individual intrahepatic transport steps is a notable feature of dynamic liver PET.

  4. Quantitative PET of liver functions

    Science.gov (United States)

    Keiding, Susanne; Sørensen, Michael; Frisch, Kim; Gormsen, Lars C; Munk, Ole Lajord

    2018-01-01

    Improved understanding of liver physiology and pathophysiology is urgently needed to assist the choice of new and upcoming therapeutic modalities for patients with liver diseases. In this review, we focus on functional PET of the liver: 1) Dynamic PET with 2-deoxy-2-[18F]fluoro-D-galactose (18F-FDGal) provides quantitative images of the hepatic metabolic clearance K met (mL blood/min/mL liver tissue) of regional and whole-liver hepatic metabolic function. Standard-uptake-value (SUV) from a static liver 18F-FDGal PET/CT scan can replace K met and is currently used clinically. 2) Dynamic liver PET/CT in humans with 11C-palmitate and with the conjugated bile acid tracer [N-methyl-11C]cholylsarcosine (11C-CSar) can distinguish between individual intrahepatic transport steps in hepatic lipid metabolism and in hepatic transport of bile acid from blood to bile, respectively, showing diagnostic potential for individual patients. 3) Standard compartment analysis of dynamic PET data can lead to physiological inconsistencies, such as a unidirectional hepatic clearance of tracer from blood (K 1; mL blood/min/mL liver tissue) greater than the hepatic blood perfusion. We developed a new microvascular compartment model with more physiology, by including tracer uptake into the hepatocytes from the blood flowing through the sinusoids, backflux from hepatocytes into the sinusoidal blood, and re-uptake along the sinusoidal path. Dynamic PET data include information on liver physiology which cannot be extracted using a standard compartment model. In conclusion, SUV of non-invasive static PET with 18F-FDGal provides a clinically useful measurement of regional and whole-liver hepatic metabolic function. Secondly, assessment of individual intrahepatic transport steps is a notable feature of dynamic liver PET. PMID:29755841

  5. Do carotid MR surface coils affect PET quantification in PET/MR imaging?

    International Nuclear Information System (INIS)

    Willemink, Martin J; Eldib, Mootaz; Leiner, Tim; Fayad, Zahi A; Mani, Venkatesh

    2015-01-01

    To evaluate the effect of surface coils for carotid MR imaging on PET quantification in a clinical simultaneous whole-body PET/MR scanner. A cylindrical phantom was filled with a homogeneous 2L water-FDG mixture at a starting dose of 301.2MBq. Clinical PET/MR and PET/CT systems were used to acquire PET-data without a coil (reference standard) and with two carotid MRI coils (Siemens Special Purpose 8-Channel and Machnet 4-Channel Phased Array). PET-signal attenuation was evaluated with Osirix using 51 (PET/MR) and 37 (PET/CT) circular ROIs. Mean and maximum standardized uptake values (SUVs) were quantified for each ROI. Furthermore, SUVs of PET/MR and PET/CT were compared. For validation, a patient was scanned with an injected dose of 407.7MBq on both a PET/CT and a PET/MR system without a coil and with both coils. PET/MR underestimations were -2.2% (Siemens) and -7.8% (Machnet) for SUVmean, and -1.2% (Siemens) and -3.3% (Machnet) for SUVmax, respectively. For PET/CT, underestimations were -1.3% (Siemens) and -1.4% (Machnet) for SUVmean and -0.5% (both Siemens and Machnet) for SUVmax, respectively using no coil data as reference. Except for PET/CT SUVmax values all differences were significant. SUVs differed significantly between PET/MR and PET/CT with SUVmean values of 0.51-0.55 for PET/MR and 0.68-0.69 for PET/CT, respectively. The patient examination showed that median SUVmean values measured in the carotid arteries decreased from 0.97 without a coil to 0.96 (Siemens) and 0.88 (Machnet). Carotid surface coils do affect attenuation correction in both PET/MR and PET/CT imaging. Furthermore, SUVs differed significantly between PET/MR and PET/CT.

  6. The beautiful invisible creativity, imagination, and theoretical physics

    CERN Document Server

    Vignale, Giovanni

    2011-01-01

    Challenging the image of theoretical physics as a dry discipline, The Beautiful Invisible shows that this highly abstract science is in fact teeming with beautiful concepts, and the task of imagining them demands profound creativity, just as creative as the work of poets or magical realist novelists such as Borges and Musil. "A good scientific theory is like a symbolic tale, an allegory of reality," writes Giovanni Vignale, as he uncovers the unexpected links between theoretical physics and artistic creativity. In engaging and at times poetic prose, and with ample quotations from many of the writers he admires, Vignale presents his own unorthodox accounts of fundamental theoretical concepts such as Newtonian mechanics, superconductivity, and Einstein's theory of relativity, illuminating their profound implications. Throughout, the author treats readers to glimpses of physics as "exercised in the still night, when only the moon rages." Indeed, as we delve behind now-familiar concepts such as "electron spin" an...

  7. Failures of Imagination: Disability and the Ethics of Selective Reproduction.

    Science.gov (United States)

    Soniewicka, Marta

    2015-10-01

    The article addresses the problem of disability in the context of reproductive decisions based on genetic information. It poses the question of whether selective procreation should be considered as a moral obligation of prospective parents. To answer this question, a number of different ethical approaches to the problem are presented and critically analysed: the utilitarian; Julian Savulescu's principle of procreative beneficence; the rights-based. The main thesis of the article is that these approaches fail to provide any appealing principles on which reproductive decisions should be based. They constitute failures of imagination which may result in counter-intuitive moral judgments about both life with disability and genetic selection. A full appreciation of the ethical significance of recognition in procreative decisions leads to a more nuanced and morally satisfying view than other leading alternatives presented in the article. © 2015 John Wiley & Sons Ltd.

  8. Dreams and imaginative processes in American and Balinese artists.

    Science.gov (United States)

    Gaines, R; Price-Williams, D

    1990-06-01

    A study is presented comparing the imaginative modes of American and Balinese artists. Strict survey comparison has not been possible owing to the lack of certain artistic types in the comparative culture and smallness of sample. By using an interview approach, a paradigmatic difference between the artistic members of the two cultures can be demonstrated. In American artists there is a more individualistic approach to creative imagery, with a stronger reliance on their dreams. In Balinese artists the creative endeavor is more collective, depending on more conscious imagery drawn from myths and common beliefs. The difference is correlated with the philosophical and cultural settings of each society in which the artist is embedded. Exemplar statements from interviews are presented to illustrate and support these propositions. Finally, it has been suggested that creative imagery should also be viewed in the perspective of differing concepts of self in the two societies.

  9. Transports of delight how technology materializes human imagination

    CERN Document Server

    Hancock, Peter

    2017-01-01

    This inspiring book shows how the spiritual side of life, with its thoughts, feelings, and aspirations, is intimately bound up with our material technologies. From the wonder of Gothic Cathedrals, to the quiet majesty of lighter than air flight, to the ultimate in luxury of the north Atlantic steamers, Peter Hancock explores how these sequential heights of technology have enabled our dreams of being transported to new and uncharted realms to become reality. Sometimes literally, sometimes figuratively, technology has always been there to make material the visions of our imagination. This book shows how this has essentially been true for all technologies from Stonehenge to space station. But technology is far from perfect. Indeed, the author argues here that some of the most public and tragic of its failures still remain instructive, emblematic, and even inspiring. He reports on examples such as a Cathedral of the Earth (Beauvais), a Cathedral of the Seas (Titanic), and a Cathedral of the Air (Hindenburg) and t...

  10. Imagining the future: The Power of Climate Change Fiction

    Science.gov (United States)

    Buhr Sullivan, S. M.; Kellagher, E.; Poppleton, K. L.

    2013-12-01

    Fiction has galvanized the public imagination around societal concerns throughout US history, on issues including slavery, worker abuse and animal cruelty. A growing body of fiction concerned with climate change, 'cli-fi', provides the opportunity for students to engage with climate science in more visceral and affective ways. The Inspiring Climate Education Excellence (ICEE) project ran a climate and energy book club from Spring 2012 through Winter 2013, in which educators, scientists and writers participated. The fictional works were intended for audiences ranging from youth through adult, with themes of dystopia, renewal, hope, oppression, and innovation. This presentation will describe the benefits, opportunities and caveats of using these works within science teaching contexts, highlight some of the works which stood out from the rest and provide an annotated bibliography of books which were included or considered.

  11. Imagination, creation and literary origins: dreaming and waking

    Directory of Open Access Journals (Sweden)

    Catherine Farrar

    2012-01-01

    Full Text Available Quotation, allusion, mediumship and speaking with or through others’ voices is an established ad well-worked aspect of culture, indeed, it seems, across all cultures, an appropriate subject indeed for COMPASIO. So too has the inspiration artists have drawn for their creation from dreams and the voices of a world beyond themselves. This has been relatively well studied in such fields as visual art and music. Less attention, however, despite its clear centrality, has been given to literary creation. This paper, by a cultural anthropologist, uses a personal case study to illustrate how this can work through the interaction between dreams and narrative. The case here, though only singular in its detailed content and process has wider implications for the comparative anthropological and comparative study of culture, individuality, imagination and creativity.

  12. Clinical applications of PET/CT

    International Nuclear Information System (INIS)

    Le Ngoc Ha

    2011-01-01

    The purpose of this article is to review the evolution of PET, PET/CT focusing on the technical aspects, PET radiopharmaceutical developments and current clinical applications as well. The newest technologic advances have been reviewed, including improved crystal design, acquisition modes, reconstruction algorithms, etc. These advancements will continue to improve contrast, decrease noise, and increase resolution. Combined PET/CT system provides faster attenuation correction and useful anatomic correlation to PET functional information. A number of new radiopharmaceuticals used for PET imaging have been developed, however, FDG have been considered as the principal PET radiotracer. The current clinical applications of PET and PET/CT are widespread and include oncology, cardiology and neurology. (author)

  13. Are Pets in the Bedroom a Problem?

    Science.gov (United States)

    Krahn, Lois E; Tovar, M Diane; Miller, Bernie

    2015-12-01

    The presence of pets in the bedroom can alter the sleep environment in ways that could affect sleep. Data were collected by questionnaire and interview from 150 consecutive patients seen at the Center for Sleep Medicine, Mayo Clinic in Arizona. Seventy-four people (49%) reported having pets, with 31 (41% of pet owners) having multiple pets. More than half of pet owners (56%) allowed their pets to sleep in the bedroom. Fifteen pet owners (20%) described their pets as disruptive, whereas 31 (41%) perceived their pets as unobtrusive or even beneficial to sleep. Health care professionals working with patients with sleep concerns should inquire about the presence of companion animals in the sleep environment to help them find solutions and optimize their sleep. Copyright © 2015 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

  14. L’imagination apprivoisée : représentation et factualité dans la connaissance historique

    Directory of Open Access Journals (Sweden)

    Pier Luigi Lecis

    2017-12-01

    Full Text Available This paper aims to show how Ricœur’s inquiry on memory, trace, and testimony contributes to rebalance a framework that, at the level of the dialectic between imagination and representation, would essentially present Historian’s work as a hermeneutical work. In Ricœur’s later writings, we find a differently balanced perspective by focusing the (neurobiological and psychological substrate of representation behind trace and memory. Representation precedes interpretation. And neither the fidelity of memory nor the epistemic truth of history belong to a game that would be solely played within the communicative space of a plurality of cognitive agents who are exchanging, controlling, and sharing their own experiences. Consequently, the reality of the past itself reemerges as the corollary of the practice of memory.

  15. Imagining flood futures: risk assessment and management in practice.

    Science.gov (United States)

    Lane, Stuart N; Landström, Catharina; Whatmore, Sarah J

    2011-05-13

    The mantra that policy and management should be 'evidence-based' is well established. Less so are the implications that follow from 'evidence' being predictions of the future (forecasts, scenarios, horizons) even though such futures define the actions taken today to make the future sustainable. Here, we consider the tension between 'evidence', reliable because it is observed, and predictions of the future, unobservable in conventional terms. For flood risk management in England and Wales, we show that futures are actively constituted, and so imagined, through 'suites of practices' entwining policy, management and scientific analysis. Management has to constrain analysis because of the many ways in which flood futures can be constructed, but also because of commitment to an accounting calculus, which requires risk to be expressed in monetary terms. It is grounded in numerical simulation, undertaken by scientific consultants who follow policy/management guidelines that define the futures to be considered. Historical evidence is needed to deal with process and parameter uncertainties and the futures imagined are tied to pasts experienced. Reliance on past events is a challenge for prediction, given changing probability (e.g. climate change) and consequence (e.g. development on floodplains). So, risk management allows some elements of risk analysis to become unstable (notably in relation to climate change) but forces others to remain stable (e.g. invoking regulation to prevent inappropriate floodplain development). We conclude that the assumed separation of risk assessment and management is false because the risk calculation has to be defined by management. Making this process accountable requires openness about the procedures that make flood risk analysis more (or less) reliable to those we entrust to produce and act upon them such that, unlike the 'pseudosciences', they can be put to the test of public interrogation by those who have to live with their consequences

  16. Game Design to Introduce Pets

    Directory of Open Access Journals (Sweden)

    Wahyu Febriyanto

    2017-02-01

    Full Text Available Introduction of animals from an early age can make children to love animals, especially pets. Children are the easiest group to receive stimulation, such as for example the stimulation of introducing children to the pet. Various media are used by parents to introduce pet. For examplle, by the media of books, multimedia, etc. One of the interesting media to introduce pet is with game. Of these problems then need to know how to make concept and design game to introduced pets for children age 3-6 years. In this paper, author formulate how to make pet game design include game genre, user interface design, image model selection, game characters, and game engine. The expected design of this game can be formulation of learning through proper game as a learning tool children. Game design derived from this writing by using model 2-dimensional images are funny and interesting coloring. And combines several game genres into one, or use the mini games that children do not get bored quickly. Design of GUI (Graphical User Interface is made as simple as possible so that children easily understand in playing this game, but also must use an interesting image

  17. Nutritional sustainability of pet foods.

    Science.gov (United States)

    Swanson, Kelly S; Carter, Rebecca A; Yount, Tracy P; Aretz, Jan; Buff, Preston R

    2013-03-01

    Sustainable practices meet the needs of the present without compromising the ability of future generations to meet their needs. Applying these concepts to food and feed production, nutritional sustainability is the ability of a food system to provide sufficient energy and essential nutrients required to maintain good health in a population without compromising the ability of future generations to meet their nutritional needs. Ecological, social, and economic aspects must be balanced to support the sustainability of the overall food system. The nutritional sustainability of a food system can be influenced by several factors, including the ingredient selection, nutrient composition, digestibility, and consumption rates of a diet. Carbon and water footprints vary greatly among plant- and animal-based ingredients, production strategy, and geographical location. Because the pet food industry is based largely on by-products and is tightly interlinked with livestock production and the human food system, however, it is quite unique with regard to sustainability. Often based on consumer demand rather than nutritional requirements, many commercial pet foods are formulated to provide nutrients in excess of current minimum recommendations, use ingredients that compete directly with the human food system, or are overconsumed by pets, resulting in food wastage and obesity. Pet food professionals have the opportunity to address these challenges and influence the sustainability of pet ownership through product design, manufacturing processes, public education, and policy change. A coordinated effort across the industry that includes ingredient buyers, formulators, and nutritionists may result in a more sustainable pet food system.

  18. The Medical Imaging & Technology Alliance conference on research endpoints appropriate for Medicare coverage of new PET radiopharmaceuticals.

    Science.gov (United States)

    Hillman, Bruce J; Frank, Richard A; Abraham, Brian C

    2013-09-01

    The outcomes of a 2011 Medical Imaging & Technology Alliance (MITA) conference helped shape considerations about what might be the most appropriate pathways for the regulatory and payment considerations of new PET radiopharmaceuticals. As follow-up to that conference, MITA convened a second conference of stakeholders to advise payers on what might be acceptable endpoints for clinical trials to support the coverage of novel PET agents. The conference involved experts on imaging and clinical research, providers of PET services, as well as representatives of interested medical societies, the PET industry, and the regulatory and payer communities. The principal outcome of their deliberations was that it was unrealistic to expect trials of new PET radiopharmaceuticals to directly demonstrate a health benefit. Rather, intermediate outcomes, such as a positive change in patient management, would be more efficient and appropriate.

  19. Imagination in human social cognition, autism, and psychotic-affective conditions.

    Science.gov (United States)

    Crespi, Bernard; Leach, Emma; Dinsdale, Natalie; Mokkonen, Mikael; Hurd, Peter

    2016-05-01

    Complex human social cognition has evolved in concert with risks for psychiatric disorders. Recently, autism and psychotic-affective conditions (mainly schizophrenia, bipolar disorder, and depression) have been posited as psychological 'opposites' with regard to social-cognitive phenotypes. Imagination, considered as 'forming new ideas, mental images, or concepts', represents a central facet of human social evolution and cognition. Previous studies have documented reduced imagination in autism, and increased imagination in association with psychotic-affective conditions, yet these sets of findings have yet to be considered together, or evaluated in the context of the diametric model. We first review studies of the components, manifestations, and neural correlates of imagination in autism and psychotic-affective conditions. Next, we use data on dimensional autism in healthy populations to test the hypotheses that: (1) imagination represents the facet of autism that best accounts for its strongly male-biased sex ratio, and (2) higher genetic risk of schizophrenia is associated with higher imagination, in accordance with the predictions of the diametric model. The first hypothesis was supported by a systematic review and meta-analysis showing that Imagination exhibits the strongest male bias of all Autism Quotient (AQ) subscales, in non-clinical populations. The second hypothesis was supported, for males, by associations between schizophrenia genetic risk scores, derived from a set of single-nucleotide polymorphisms, and the AQ Imagination subscale. Considered together, these findings indicate that imagination, especially social imagination as embodied in the default mode human brain network, mediates risk and diametric dimensional phenotypes of autism and psychotic-affective conditions. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. Activation of sensory cortex by imagined genital stimulation: an fMRI analysis.

    Science.gov (United States)

    Wise, Nan J; Frangos, Eleni; Komisaruk, Barry R

    2016-01-01

    During the course of a previous study, our laboratory made a serendipitous finding that just thinking about genital stimulation resulted in brain activations that overlapped with, and differed from, those generated by physical genital stimulation. This study extends our previous findings by further characterizing how the brain differentially processes physical 'touch' stimulation and 'imagined' stimulation. Eleven healthy women (age range 29-74) participated in an fMRI study of the brain response to imagined or actual tactile stimulation of the nipple and clitoris. Two additional conditions - imagined dildo self-stimulation and imagined speculum stimulation - were included to characterize the effects of erotic versus non-erotic imagery. Imagined and tactile self-stimulation of the nipple and clitoris each activated the paracentral lobule (the genital region of the primary sensory cortex) and the secondary somatosensory cortex. Imagined self-stimulation of the clitoris and nipple resulted in greater activation of the frontal pole and orbital frontal cortex compared to tactile self-stimulation of these two bodily regions. Tactile self-stimulation of the clitoris and nipple activated the cerebellum, primary somatosensory cortex (hand region), and premotor cortex more than the imagined stimulation of these body regions. Imagining dildo stimulation generated extensive brain activation in the genital sensory cortex, secondary somatosensory cortex, hippocampus, amygdala, insula, nucleus accumbens, and medial prefrontal cortex, whereas imagining speculum stimulation generated only minimal activation. The present findings provide evidence of the potency of imagined stimulation of the genitals and that the following brain regions may participate in erogenous experience: primary and secondary sensory cortices, sensory-motor integration areas, limbic structures, and components of the 'reward system'. In addition, these results suggest a mechanism by which some individuals may

  1. Diagnosis of functional loss using with PET or SPECT

    International Nuclear Information System (INIS)

    Maeda, Tetsuya; Nagata, Ken

    2009-01-01

    Described are outlines of positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging, and their application to diagnosis of brain diseases accompanying functional loss. PET imaging by annihilation photons is useful to see the brain metabolic activity with use of compounds labeled by positron emitters like 11 C, 15 O, 13 N and 18 F. Cerebral blood flow (CBF), CB volume and oxygen extraction fraction correlate well with the cerebral activity and can be measured by PET with C 15 O 2 , H 2 15 O or 15 O 2 . 18 F-glucose is usable to measure the cerebral metabolic rate of glucose. SPECT imaging by γ-rays of 133 Xe, 123 I-iofetamine (IMP), 99m Tc-hexamethyl propylene amine oxime (HMPAO) and 99m Tc-ethyl cysteinate dimer (ECD) is useful also to measure CBF in different mechanisms from agent to agent, which often reflect the pathophysiology of the lesion in problem. These imaging techniques are applied to the diagnosis of regional functional loss in ischemic brain diseases like infarction, dementia (Alzheimer and multiple vascular) and Parkinsonism, of which characters and details of actual images are presented herein. Authors say that although the imaging diagnosis for brain functional loss has progressed, the integration of neurological finding, clinical process and simple morphological brain image as well is still important in the routine examination. (K.T.)

  2. What do we measure in oncology PET?

    Energy Technology Data Exchange (ETDEWEB)

    Pak, Kyoung June; Kim, Seong Jang [Dept. of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan (Korea, Republic of)

    2017-09-15

    Positron emission tomography (PET) has come to the practice of oncology. It is known that {sup 18}F-fluorodeoxyglucose (FDG) PET is more sensitive for the assessment of treatment response than conventional imaging. In addition, PET has an advantage in the use of quantitative analysis of the study. Nowadays, various PET parameters are adopted in clinical settings. In addition, a wide range of factors has been known to be associated with FDG uptake. Therefore, there has been a need for standardization and harmonization of protocols and PET parameters. We will introduce PET parameters and discuss major issues in this review.

  3. Undergraduate Leadership Students' Self-Perceived Level of Moral Imagination: An Innovative Foundation for Morality-Based Leadership Curricula

    Science.gov (United States)

    Odom, Summer F.; Andenoro, Anthony C.; Sandlin, M'Randa R.; Jones, Jaron L.

    2015-01-01

    Leadership educators are faced with the challenge of preparing students to serve organizations and people in dynamic and ever changing contexts. The purpose of this study was to examine undergraduate leadership students' self-perceived level of moral imagination to make recommendations for moral imagination curricula. Moral imagination is the…

  4. The system of the designing for PET detectors

    International Nuclear Information System (INIS)

    Fang Zongliang

    2006-01-01

    PET stands for Positron Emission Tomography, a new nuclear medicine imaging device. PET detector is the key of PET. This paper introduces a system of the designing for PET detector. The system can be used to design various PET detector. A PET detector BLOCK with 8 x 8 crystals has been designed and built by this system. (authors)

  5. Trading Agents

    CERN Document Server

    Wellman, Michael

    2011-01-01

    Automated trading in electronic markets is one of the most common and consequential applications of autonomous software agents. Design of effective trading strategies requires thorough understanding of how market mechanisms operate, and appreciation of strategic issues that commonly manifest in trading scenarios. Drawing on research in auction theory and artificial intelligence, this book presents core principles of strategic reasoning that apply to market situations. The author illustrates trading strategy choices through examples of concrete market environments, such as eBay, as well as abst

  6. Nonisothermal melt-crystallization kinetics for in situ prepared poly(ethylene terephthalate)/monmorilonite (PET/OMMT)

    International Nuclear Information System (INIS)

    Antoniadis, G.; Paraskevopoulos, K.M.; Vassiliou, A.A.; Papageorgiou, G.Z.; Bikiaris, D.; Chrissafis, K.

    2011-01-01

    Highlights: → The melting temperature of the nanocomposites was shifted slightly to higher temperatures. → OMMT can act as nucleating agent. → The samples present lower activation energy compared to that of neat PET. → They crystallized by mechanisms with different activation energies. - Abstract: Poly(ethylene terephthalate) (PET) montmorillonite nanocomposites were prepared by in situ polymerization containing 0.5, 1, 2 and 5 wt% of organically modified montmorillonite (OMMT). In order to prepare exfoliated nanocomposites a new thermally stable modifier for montmorillonite nanoparticles like chlorohexadecane triphenylphosphine (CHDTPP) was synthesized. The preparation of nanocomposites was carried out using the two-stage melt polycondensation method. As verified by TEM micrographs, the dispersion of OMMT nanoparticles into the PET matrix was homogeneous while these were dispersed in the exfoliated form, proving the effectiveness of the modifier. The influence of OMMT nanomaterials on the thermal behaviour of PET and its non-isothermal crystallization was studied. Furthermore, the crystallization kinetics of PET and its nanocomposites were investigated by DSC. The activation energy was calculated using the Friedman's method. The Avrami exponent was calculated and analyzed. The effect of OMMT nanoparticles on spherulite growth rate of PET in all nanocomposites was also evaluated using the modified Lauritzen-Hoffman equation. From all these results it was found that OMMT nanoparticles can act as nucleating agents enhancing the crystallization rate of PET. The dispersion of OMMT nanoparticles in exfoliate form plays also an important role.

  7. Molecular Imaging of Hydrolytic Enzymes Using PET and SPECT.

    Science.gov (United States)

    Rempel, Brian P; Price, Eric W; Phenix, Christopher P

    2017-01-01

    Hydrolytic enzymes are a large class of biological catalysts that play a vital role in a plethora of critical biochemical processes required to maintain human health. However, the expression and/or activity of these important enzymes can change in many different diseases and therefore represent exciting targets for the development of positron emission tomography (PET) and single-photon emission computed tomography (SPECT) radiotracers. This review focuses on recently reported radiolabeled substrates, reversible inhibitors, and irreversible inhibitors investigated as PET and SPECT tracers for imaging hydrolytic enzymes. By learning from the most successful examples of tracer development for hydrolytic enzymes, it appears that an early focus on careful enzyme kinetics and cell-based studies are key factors for identifying potentially useful new molecular imaging agents.

  8. [Microdose clinical trial--impact of PET molecular imaging].

    Science.gov (United States)

    Yano, Tsuneo; Watanabe, Yasuyoshi

    2010-10-01

    Microdose (MD) clinical trial and exploratory IND study including sub-therapeutic dose and therapeutic dose which are higher than microdoses are expected to bring about innovations in drug development. The outlines of guidances for microdose clinical trial and ICH-M3 (R2) issued by the MHLW in June, 2008, and February, 2010, are first explained, respectively, and some examples of their application to clinical developments of therapeutic drugs in the infection and cancer fields are introduced. Especially, thanks to the progress of molecular imaging research, a new field of drug development is explored by using imaging biomarkers for efficacy or safety evaluation which visualize biomarkers by PET imaging agents. Finally, the roadmap for drug development in infection and cancer fields utilizing PET molecular imaging is discussed.

  9. Comparison of PET/CT with Sequential PET/MRI Using an MR-Compatible Mobile PET System.

    Science.gov (United States)

    Nakamoto, Ryusuke; Nakamoto, Yuji; Ishimori, Takayoshi; Fushimi, Yasutaka; Kido, Aki; Togashi, Kaori

    2018-05-01

    The current study tested a newly developed flexible PET (fxPET) scanner prototype. This fxPET system involves dual arc-shaped detectors based on silicon photomultipliers that are designed to fit existing MRI devices, allowing us to obtain fused PET and MR images by sequential PET and MR scanning. This prospective study sought to evaluate the image quality, lesion detection rate, and quantitative values of fxPET in comparison with conventional whole-body (WB) PET and to assess the accuracy of registration. Methods: Seventeen patients with suspected or known malignant tumors were analyzed. Approximately 1 h after intravenous injection of 18 F-FDG, WB PET/CT was performed, followed by fxPET and MRI. For reconstruction of fxPET images, MRI-based attenuation correction was applied. The quality of fxPET images was visually assessed, and the number of detected lesions was compared between the 2 imaging methods. SUV max and maximum average SUV within a 1 cm 3 spheric volume (SUV peak ) of lesions were also compared. In addition, the magnitude of misregistration between fxPET and MR images was evaluated. Results: The image quality of fxPET was acceptable for diagnosis of malignant tumors. There was no significant difference in detectability of malignant lesions between fxPET and WB PET ( P > 0.05). However, the fxPET system did not exhibit superior performance to the WB PET system. There were strong positive correlations between the 2 imaging modalities in SUV max (ρ = 0.88) and SUV peak (ρ = 0.81). SUV max and SUV peak measured with fxPET were approximately 1.1-fold greater than measured with WB PET. The average misregistration between fxPET and MR images was 5.5 ± 3.4 mm. Conclusion: Our preliminary data indicate that running an fxPET scanner near an existing MRI system provides visually and quantitatively acceptable fused PET/MR images for diagnosis of malignant lesions. © 2018 by the Society of Nuclear Medicine and Molecular Imaging.

  10. Comparison of PET and fMRI activation patterns during declarative memory processes

    International Nuclear Information System (INIS)

    Mottaghy, F.M.; Krause, B.J.; Schmidt, D.; Hautzel, H.; Mueller-Gaertner, H.-W.; Herzog, H.; Shah, N.J.; Halsband, U.

    2000-01-01

    Aim: In this study neuronal correlates of encoding and retrieval in paired association learning were compared using two different neuroimaging methods: Positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). Methods: 6 right-handed normal male volunteers took part in the study. Each subject underwent six 0-15-butanol PET scans and an fMRI study comprising four single epochs on a different day. The subjects had to learn and retrieve 12 word pairs which were visually presented (highly imaginable words, not semantically related). Results: Mean recall accuracy was 93% in the PET as well as in the fMRI experiment. During encoding and retrieval we found anterior cingulate cortex activation, and bilateral prefrontal cortex activation in both imaging modalities. Furthermore, we demonstrate the importance of the precuneus in episodic memory. With PET the results demonstrate frontopolar activations whereas fMRI fails to show activations in this area probably due to susceptibility artifacts. In fMRI we found additionally parahippocampal activation and due to the whole-brain coverage cerebellar activation during encoding. The distance between the center-of-mass activations in both modalities was 7.2±6.5 mm. Conclusion: There is a preponderance of commonalities in the activation patterns yielded with fMRI and PET. However, there are also important differences. The decision to choose one or the other neuroimaging modality should among other aspects depend on the study design (single subject vs. group study) and the task of interest. (orig.) [de

  11. Detection of Cancer with PET and PET/CT in Asymptomatic Volunteers

    International Nuclear Information System (INIS)

    Chung, Ji In; Choi, Joon Young; Lee, Kyung Han; Kim, Byung Tae; Choi, Yoon Ho; Cho, Han Byoul; Shim, Jae Yong

    2009-01-01

    We retrospectively investigated the diagnostic performance of 18 F-fluorodeoxyglucose positron emission tomography (PET) and PET/CT for cancer detection in asymptomatic health-check examinees. This study consisted of 5091 PET or PET/CT conducted as part of annual health examination at one hospital from March 1998 to February 2008. To find the incidence of cancers, medical records of the subjects were thoroughly reviewed for a follow-up period of one year. The patterns of formal readings of PET and PET/CT were analyzed to assess the sensitivity and specificity for cancer detection. The histopathology and stage of the cancers were evaluated in relation to the results of PET. Eighty-six cancers (1.7%) were diagnosed within one year after PET or PET/CT. When PET and PET/CT results were combined, the sensitivity was 48.8% and specificity was 81.1% for cancer detection. PET only had a sensitivity of 46.2% and a specificity of 81.4%, and PET/CT only had a sensitivity of 75.0% and a specificity of 78.5% respectively. There were no significant differences in cancer site, stage and histopathology between PET positive and PET negative cancers. In 19.3% of formal readings of PET and PET/CT, further evaluation to exclude malignancy or significant disease was recommended. Head and neck area and upper gastrointestinal tract were commonly recommended sites for further evaluation. PET and PET/CT showed moderate performance for detecting cancers in asymptomatic adults in this study. More experience and further investigation are needed to overcome limitations of PET and PET/CT for cancer screening

  12. Generativity and imagination in autism spectrum disorder: evidence from individual differences in children's impossible entity drawings.

    Science.gov (United States)

    Low, Jason; Goddard, Elizabeth; Melser, Joseph

    2009-06-01

    This study examined the cognitive underpinnings of spontaneous imagination in autism spectrum disorder (ASD) by way of individual differences. Children with ASD (N = 27) and matched typically developing (TD) children were administered Karmiloff-Smith's (1990) imaginative drawing task, along with measures that tapped specific executive functions (generativity, visuospatial planning, and central coherence processing style) and false belief theory of mind (ToM) understanding. The ASD group drawings displayed deficits in imaginative content and a piecemeal pictorial style. ASD participants also showed group deficits in generativity, planning and ToM, and exhibited weak coherence. Individual differences in generativity were related to imaginative drawing content in the ASD group, and the association was mediated through planning ability. Variations in weak coherence were separately related to a piecemeal drawing style in the ASD group. Variations in generativity were also linked with imaginative drawing content in the TD group; the connection unfolded when it received pooled variance from receptive language ability, and thereupon mediated through false belief reasoning to cue imaginative content. Results are discussed in terms of how generativity plays a broad and important role for imagination in ASD and typical development, albeit in different ways.

  13. Parasites in pet reptiles

    Directory of Open Access Journals (Sweden)

    Mavri Urška

    2011-05-01

    Full Text Available Abstract Exotic reptiles originating from the wild can be carriers of many different pathogens and some of them can infect humans. Reptiles imported into Slovenia from 2000 to 2005, specimens of native species taken from the wild and captive bred species were investigated. A total of 949 reptiles (55 snakes, 331 lizards and 563 turtles, belonging to 68 different species, were examined for the presence of endoparasites and ectoparasites. Twelve different groups (Nematoda (5, Trematoda (1, Acanthocephala (1, Pentastomida (1 and Protozoa (4 of endoparasites were determined in 26 (47.3% of 55 examined snakes. In snakes two different species of ectoparasites were also found. Among the tested lizards eighteen different groups (Nematoda (8, Cestoda (1, Trematoda (1, Acanthocephala (1, Pentastomida (1 and Protozoa (6 of endoparasites in 252 (76.1% of 331 examined animals were found. One Trombiculid ectoparasite was determined. In 563 of examined turtles eight different groups (Nematoda (4, Cestoda (1, Trematoda (1 and Protozoa (2 of endoparasites were determined in 498 (88.5% animals. In examined turtles three different species of ectoparasites were seen. The established prevalence of various parasites in reptiles used as pet animals indicates the need for examination on specific pathogens prior to introduction to owners.

  14. PET and PET/CT in oncology: the key of diagnostic challenge

    International Nuclear Information System (INIS)

    Mortelmans, L.; Stroobants, S.; Spaepen, K.

    2004-01-01

    In this presentation authors present use of positron emission tomography (PET) in oncology. This lecture is divided to the following parts: (1) Assessment of treatment response; (2) Treatment monitoring by PET: clinical examples; (3) PET for early response assessment; (4) Use of PET in Radiotherapy planning

  15. Quantitative PET imaging with the 3T MR-BrainPET

    International Nuclear Information System (INIS)

    Weirich, C.; Scheins, J.; Lohmann, P.; Tellmann, L.; Byars, L.; Michel, C.; Rota Kops, E.; Brenner, D.; Herzog, H.; Shah, N.J.

    2013-01-01

    The new hybrid imaging technology of MR-PET allows for simultaneous acquisition of versatile MRI contrasts and the quantitative metabolic imaging with PET. In order to achieve the quantification of PET images with minimal residual error the application of several corrections is crucial. In this work we present our results on quantification with the 3T MR BrainPET scanner

  16. Biodistribution and PET imaging of [18F]-fluoroadenosine derivatives

    International Nuclear Information System (INIS)

    Alauddin, Mian M.; Shahinian, Antranik; Park, Ryan; Tohme, Michael; Fissekis, John D.; Conti, Peter S.

    2007-01-01

    Introduction: Many fluorinated analogues of adenosine nucleoside have been synthesized and studied as potential antitumor and antiviral agents. Earlier, we reported radiosynthesis of 2'-deoxy-2'-[ 18 F]fluoro-1-β-D-arabinofuranosyl-adenine ([ 18 F]-FAA) and 3'-deoxy-3'-[ 18 F]fluoro-1-β-D-xylofuranosyl-adenine ([ 18 F]FXA). Now, we report their in vivo studies including blood clearance, biodistribution and micro-PET imaging in tumor-bearing nude mice. Methods: Tumors were grown in 6-week-old athymic nude mice (Harlan, Indianapolis, IN, USA) by inoculation of HT-29 cells, wild-type cells in the left flank and transduced cells with HSV-tk on the right flank. When the tumor was about 1 cm in size, animals were injected with these radiotracers for in vivo studies, including blood clearance, micro-PET imaging and biodistribution. Results: Uptake of [ 18 F]FAA in tumor was 3.3-fold higher than blood, with highest uptake in the spleen. Maximum uptake of [ 18 F]FXA was observed in the heart compared to other organs. There was no tumor uptake of [ 18 F]FXA. Biodistribution results were supported by micro-PET images, which also showed very high uptake of [ 18 F]FAA in spleen and visualization of tumors, and high uptake of [ 18 F]FXA in the heart. Conclusion: These results suggest that [ 18 F]FAA may be useful for tumor imaging, while [ 18 F]FXA may have potential as a heart imaging agent with PET

  17. Effect of PVP on the characteristic of modified membranes made from waste PET bottles for humic acid removal [version 2; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Nasrul Arahman

    2017-06-01

    Full Text Available Background: The aim of the present study was to evaluate the possibility of using recycled polymer (waste polyethylene terephthalate [PET] bottles as a membrane material. Furthermore, the effect of the addition of a pore-forming agent and preparation conditions was also observed. Methods: Porous polymeric membranes were prepared via thermally induced phase separation by dissolving recycled PET in phenol. PET polymer was obtained from waste plastic bottles as a new source of polymeric material. For original PET membrane, the casting solution was prepared by dissolving of 20wt% PET in phenol solution. For PET modified membrane, a 5 wt% of polyvinylpyrrolidone (PVP was added into polymer solution. The solution was cast onto a glass plate at room temperature followed by evaporation before the solidification process. The membranes formed were characterized in terms of morphology, chemical group, and filtration performance. A humic acid solution was used to identify the permeability and the solute rejection of the membranes. Results: The results showed that the recycled PET from waste plastic bottles was applicable to use as a membrane material for a water treatment process. The maximum flux of 97.0 l/m2.hr was obtained from filtration test using PET membrane. The highest rejection of humic acid in a water sample, which reached up to 75.92%, was obtained using the PET/PVP membrane. Conclusions: The recycled PET from waste bottles was successfully used to prepare porous membrane. The membrane was modified by the addition of PVP as a membrane modifying agent. SEM analysis confirmed that the original PET membrane has a rough and large pore structure. The addition of PVP improved the pore density with a narrow pore structure. The PET/PVP membrane conditioned with evaporation was the best in humic acid rejection.

  18. Clinical usefulness of PET in the management of oral cancer. Comparison between FDG-PET and MET-PET

    International Nuclear Information System (INIS)

    Kitagawa, Yoshimasa; Saitoh, Masaaki; Nakamura, Mikiko

    2007-01-01

    Inductive chemoradiotherapy has played an important role in preserving organs and functions in patients with oral squamous cell carcinoma (SCC). To determine whether a reduced form of surgery should be performed after chemoradiotherapy, accurate evaluation of residual tumor cells is essential. We investigated the clinical value of positron emission tomography with 18 F labeled fluorodeoxyglucose (FDG-PET) in the management of oral SCCs. Forty-five patients underwent two FDG-PET studies, one prior to and one at 6 weeks after the chemoradiotherapy. Pretreatment FDG-PET was useful in predicting the response to treatment. Posttreatment FDG-PET could evaluate residual viable cells and prognosis. Organ preservation may be feasible based on PET evaluation. Hence FDG-PET is a valuable tool in the treatment of oral cancer. 11 C-Methionine (MET) is another promising tracer for PET that can be used to assess metabolic demand for amino acids in cancer cells. A MET-PET and FDG-PET study was performed during the same period to investigate diagnostic accuracy in 40 oral malignancies. Sensitivity and positive predictive value of MET-PET were 95% and 100%, respectively, and were comparable with those of FDG-PET. Further study is required to determine the diagnostic significance of MET-PET in evaluating response to chemoradiotherapy. (author)

  19. Activation of sensory cortex by imagined genital stimulation: an fMRI analysis

    Directory of Open Access Journals (Sweden)

    Nan J. Wise

    2016-10-01

    Full Text Available Background: During the course of a previous study, our laboratory made a serendipitous finding that just thinking about genital stimulation resulted in brain activations that overlapped with, and differed from, those generated by physical genital stimulation. Objective: This study extends our previous findings by further characterizing how the brain differentially processes physical ‘touch’ stimulation and ‘imagined’ stimulation. Design: Eleven healthy women (age range 29–74 participated in an fMRI study of the brain response to imagined or actual tactile stimulation of the nipple and clitoris. Two additional conditions – imagined dildo self-stimulation and imagined speculum stimulation – were included to characterize the effects of erotic versus non-erotic imagery. Results: Imagined and tactile self-stimulation of the nipple and clitoris each activated the paracentral lobule (the genital region of the primary sensory cortex and the secondary somatosensory cortex. Imagined self-stimulation of the clitoris and nipple resulted in greater activation of the frontal pole and orbital frontal cortex compared to tactile self-stimulation of these two bodily regions. Tactile self-stimulation of the clitoris and nipple activated the cerebellum, primary somatosensory cortex (hand region, and premotor cortex more than the imagined stimulation of these body regions. Imagining dildo stimulation generated extensive brain activation in the genital sensory cortex, secondary somatosensory cortex, hippocampus, amygdala, insula, nucleus accumbens, and medial prefrontal cortex, whereas imagining speculum stimulation generated only minimal activation. Conclusion: The present findings provide evidence of the potency of imagined stimulation of the genitals and that the following brain regions may participate in erogenous experience: primary and secondary sensory cortices, sensory-motor integration areas, limbic structures, and components of the

  20. 18F-FDG PET as a single imaging modality in pediatric neuroblastoma. Comparison with abdomen CT and bone scintigraphy

    International Nuclear Information System (INIS)

    Choi, Yun Jung; Hwang, Hee Sung; Kim, Hyun Jeong; Jeong, Yong Hyu; Cho, Arthur; Lee, Jae Hoon; Yun, Mijin; Lee, Jong Doo; Kang, Won Jun

    2014-01-01

    The purpose of this study was to evaluate the diagnostic performance of 18 F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) as a single imaging agent in neuroblastoma in comparison with other imaging modalities. A total of 30 patients with pathologically proven neuroblastoma who underwent FDG PET for staging were enrolled. Diagnostic performance of FDG PET and abdomen CT was compared in detecting soft tissue lesions. FDG PET and bone scintigraphy (BS) were compared in bone metastases. Maximal standardized uptake value (SUVmax) of primary or recurrent lesions was calculated for quantitative analysis. Tumor FDG uptake was detected in 29 of 30 patients with primary neuroblastoma. On initial FDG PET, SUVmax of primary lesions were lower in early stage (I-II) than in late stage (III-IV) (3.03 vs. 5.45, respectively, p=0.019). FDG PET was superior to CT scan in detecting distant lymph nodes (23 vs. 18 from 23 lymph nodes). FDG PET showed higher accuracy to identify bone metastases than BS both on patient-based analyses (100 vs. 94.4% in sensitivity, 100 vs. 77.8% in specificity), and on lesion-based analyses (FDG PET: 203 lesions, BS: 86 lesions). Sensitivity and specificity of FDG PET to detect recurrence were 87.5% and 93.8, respectively. FDG PET was superior to CT in detecting distant LN metastasis and to BS in detecting skeletal metastasis in neuroblastoma. BS might be eliminated in the evaluation of neuroblastoma when FDG PET is performed. (author)