Inversion Algorithms and PS Detection in SAR Tomography, Case Study of Bucharest City

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C. Dănişor

2016-06-01

Full Text Available Synthetic Aperture Radar (SAR tomography can reconstruct the elevation profile of each pixel based on a set of co-registered complex images of a scene. Its main advantage over classical interferometric methods consists in the capability to improve the detection of single persistent scatterers as well as to enable the detection of multiple scatterers interfering within the same pixel. In this paper, three tomographic algorithms are compared and applied to a dataset of 32 images to generate the elevation map of dominant scatterers from a scene. Targets which present stable proprieties over time - Persistent Scatterers (PS are then detected based on reflectivity functions reconstructed with Capon filtering.

Hybrid fs/ps CARS for Sooting and Particle-laden Flames [PowerPoint

Energy Technology Data Exchange (ETDEWEB)

Hoffmeister, Kathryn N. Gabet; Guildenbecher, Daniel Robert; Kearney, Sean P.

2016-01-01

We report the application of ultrafast rotational coherent anti-Stokes Raman scattering (CARS) for temperature and relative oxygen concentration measurements in the plume emanating from a burning aluminized ammonium perchlorate propellant strand. Combustion of these metal-based propellants is a particularly hostile environment for laserbased diagnostics, with intense background luminosity, scattering and beam obstruction from hot metal particles that can be as large as several hundred microns in diameter. CARS spectra that were previously obtained using nanosecond pulsed lasers in an aluminumparticle- seeded flame are examined and are determined to be severely impacted by nonresonant background, presumably as a result of the plasma formed by particulateenhanced laser-induced breakdown. Introduction of fs/ps laser pulses enables CARS detection at reduced pulse energies, decreasing the likelihood of breakdown, while simultaneously providing time-gated elimination of any nonresonant background interference. Temperature probability densities and temperature/oxygen correlations were constructed from ensembles of several thousand single-laser-shot measurements from the fs/ps rotational CARS measurement volume positioned within 3 mm or less of the burning propellant surface. Preliminary results in canonical flames are presented using a hybrid fs/ps vibrational CARS system to demonstrate our progress towards acquiring vibrational CARS measurements for more accurate temperatures in the very high temperature propellant burns.

Automated classification of Permanent Scatterers time-series based on statistical characterization tests

Science.gov (United States)

Berti, Matteo; Corsini, Alessandro; Franceschini, Silvia; Iannacone, Jean Pascal

2013-04-01

The application of space borne synthetic aperture radar interferometry has progressed, over the last two decades, from the pioneer use of single interferograms for analyzing changes on the earth's surface to the development of advanced multi-interferogram techniques to analyze any sort of natural phenomena which involves movements of the ground. The success of multi-interferograms techniques in the analysis of natural hazards such as landslides and subsidence is widely documented in the scientific literature and demonstrated by the consensus among the end-users. Despite the great potential of this technique, radar interpretation of slope movements is generally based on the sole analysis of average displacement velocities, while the information embraced in multi interferogram time series is often overlooked if not completely neglected. The underuse of PS time series is probably due to the detrimental effect of residual atmospheric errors, which make the PS time series characterized by erratic, irregular fluctuations often difficult to interpret, and also to the difficulty of performing a visual, supervised analysis of the time series for a large dataset. In this work is we present a procedure for automatic classification of PS time series based on a series of statistical characterization tests. The procedure allows to classify the time series into six distinctive target trends (0=uncorrelated; 1=linear; 2=quadratic; 3=bilinear; 4=discontinuous without constant velocity; 5=discontinuous with change in velocity) and retrieve for each trend a series of descriptive parameters which can be efficiently used to characterize the temporal changes of ground motion. The classification algorithms were developed and tested using an ENVISAT datasets available in the frame of EPRS-E project (Extraordinary Plan of Environmental Remote Sensing) of the Italian Ministry of Environment (track "Modena", Northern Apennines). This dataset was generated using standard processing, then the

Positron scattering by rubidium and caesium

International Nuclear Information System (INIS)

Kernoghan, A.A.; Walters, H.R.J.; McAlinden, M.T.

1996-01-01

We report results in the energy range 0.5 to 64 eV for positron scattering by ground state rubidium and caesium in Ps(1s,2s,2p,3s,3p,3d) + Rb(5s,5p,6s,6p,4d) and Ps(1s,2s,2p,3s,3p,3d) + Cs(6s,6p,7s,7p,5d) coupled-state approximations, respectively. The pattern of results is similar to analogous calculations made on potassium by McAlinden et al. Except at the lowest energies, positronium formation is found to be almost entirely into excited states, with there being a dramatic collapse of the Ps(1s) cross section in the case of caesium. Ps(n = 2), Ps(n = 3) and Ps(n≥ 4) cross sections are predicted to be of comparable size. Ps(n≥ 4) formation is estimated from the calculated Ps(n = 3) results using the n 3 scaling rule. Good agreement in shape and magnitude is obtained with the recent lower bound measurements of total positronium formation in rubidium by Surdutovich et al, although there are differences in detail. Good agreement is also achieved with the total cross section measurements of Parikh et al on rubidium after these have been corrected for discrimination against forward elastic scattering and renormalized upwards by 5%. These total cross section measurements display a pronounced peak near 6 eV which is well reproduced by the present theory but is at variance with the earlier Rb(5s,5p,6s,6p,4d) calculations of McEachran et al which neglect positronium formation. This peak, which also appears in the calculations on potassium and caesium, is primarily associated with the maximum in the total positronium formation cross section. At low energies elastic scattering is dominant, this dominance being directly taken over by the resonance excitation of the atom with increasing impact energy. The next most important cross section is positronium formation, followed by excitation of the lowest atomic d-state. The 5s → 6s and 5s → 6p transitions in rubidium and the 6s → 7s and 6s → 7p transitions in caesium are of relatively minor importance. (Author)

Comparison of retrievable stents and permanent stents for Budd-Chiari syndrome due to obstructive inferior vena cava.

Science.gov (United States)

Bi, Yonghua; Chen, Hongmei; Ding, Penxu; Ren, Jianzhuang; Han, Xinwei

2018-05-30

To compare long-term outcomes of retrievable stents and permanent stents for BCS due to long-segment obstructive IVC. Between July 2000 and August 2016, 42 patients with BCS due to long-segment obstructive IVC were treated with retrievable stents (RS) and 41 patients were treated with permanent stents (PS). The retrievable stents was removed eventually after thrombus disappeared. Patients were subsequently followed-up by color Doppler sonography or CT scanning. All retrievable stent placements were successfully, and 37 retrievable stents were retrieved 8 to 29 days later. Forty-two stents were implanted in PS Group. One failure retrieval of retrievable stents occurred, and two failures of cannulations were found in PS Group. Two deaths may procedure-related and died from acute pulmonary thromboembolism perioperatively. One patient developed acute cerebral infarction and recovered after treatment. In PS Group, minor complications were found in 3 patients. The length of IVC lesion segment, length and thickness of IVC thrombus decreased significantly, and diameter of retrocaval IVC and diaphragm IVC increased significantly in both groups. During follow up, 3 patients died from liver failure in RS Group and 2 patients died in PS Group. RS Group showed a significantly higher primary patency rate than PS Group. Cumulative 1-, 3-, and 5-year secondary patency rates were 95.2%, 89.6%, 89.6% in RS Group, and 100%, 96.6%, 96.6% in PS Group (p= 0.7109). Retrievable stents is effective for BCS due to long-segment obstructive IVC, with a higher primary patency rate. This article is protected by copyright. All rights reserved.

Permanently calibrated interpolating time counter

International Nuclear Information System (INIS)

Jachna, Z; Szplet, R; Kwiatkowski, P; Różyc, K

2015-01-01

We propose a new architecture of an integrated time interval counter that provides its permanent calibration in the background. Time interval measurement and the calibration procedure are based on the use of a two-stage interpolation method and parallel processing of measurement and calibration data. The parallel processing is achieved by a doubling of two-stage interpolators in measurement channels of the counter, and by an appropriate extension of control logic. Such modification allows the updating of transfer characteristics of interpolators without the need to break a theoretically infinite measurement session. We describe the principle of permanent calibration, its implementation and influence on the quality of the counter. The precision of the presented counter is kept at a constant level (below 20 ps) despite significant changes in the ambient temperature (from −10 to 60 °C), which can cause a sevenfold decrease in the precision of the counter with a traditional calibration procedure. (paper)

Vesicle formation in the block copolymer/ homopolymer mixture studied by scattering methods

International Nuclear Information System (INIS)

Koizumi, Satoshi; Hasegawa, Hirokazu; Hashimoto, Takeji; Suzuki, Junnich.

1993-01-01

We studied morphology and spatial segmental distribution of particular binary mixtures of poly(styrene-block-isoprene)(SI) and homopolystyren, either protonated (HS) or deuterated (DS), with small angle-X-ray scattering (SAXS) and neutron scattering (SANS). The block copolymer SI used itself had a lamellar microdomain. Molecular weights of HS and DS were identical to each other and equal also to that of polystyrene block (PS) in SI. SAXS results obtained for SI and HS mixtures show that: (1) HS is solubilized in the PS microdomains; (2) the polyisoprene lamella has the thickness independent of w HS , weight fraction of HS, but its undulation depends on w HS . These two findings, in turn, imply that the HS added is localized in the middle of the PS microdomains, i.e., in between the PS brushes emanating from the interface of SI. We further confirmed this implication by SANS with a deuterium labeling technique; the DS segments studied for the SI/DS mixture is localized in the middle of PS microdomain with the penetration depth of 10 nm between DS and PS block chains. (author)

Au coated PS nanopillars as a highly ordered and reproducible SERS substrate

Science.gov (United States)

Kim, Yong-Tae; Schilling, Joerg; Schweizer, Stefan L.; Sauer, Guido; Wehrspohn, Ralf B.

2017-07-01

Noble metal nanostructures with nanometer gap size provide strong surface-enhanced Raman scattering (SERS) which can be used to detect trace amounts of chemical and biological molecules. Although several approaches were reported to obtain active SERS substrates, it still remains a challenge to fabricate SERS substrates with high sensitivity and reproducibility using low-cost techniques. In this article, we report on the fabrication of Au sputtered PS nanopillars based on a template synthetic method as highly ordered and reproducible SERS substrates. The SERS substrates are fabricated by anodic aluminum oxide (AAO) template-assisted infiltration of polystyrene (PS) resulting in hemispherical structures, and a following Au sputtering process. The optimum gap size between adjacent PS nanopillars and thickness of the Au layers for high SERS sensitivity are investigated. Using the Au sputtered PS nanopillars as an active SERS substrate, the Raman signal of 4-methylbenzenethiol (4-MBT) with a concentration down to 10-9 M is identified with good signal reproducibility, showing great potential as promising tool for SERS-based detection.

Asymmetric PS-block-(PS-co-PB)-block-PS block copolymers: morphology formation and deformation behaviour

International Nuclear Information System (INIS)

Adhikari, Rameshwar; Huy, Trinh An; Buschnakowski, Matthias; Michler, Goerg H; Knoll, Konrad

2004-01-01

Morphology formation and deformation behaviour of asymmetric styrene/butadiene triblock copolymers (total polystyrene (PS) content ∼70%) consisting of PS outer blocks held apart by a styrene-co-butadiene random copolymer block (PS-co-PB) each were investigated. The techniques used were differential scanning calorimetry, transmission electron microscopy, uniaxial tensile testing and Fourier-transform infrared spectroscopy. A significant shift of the phase behaviour relative to that of a neat symmetric triblock copolymer was observed, which can be attributed to the asymmetric architecture and the presence of PS-co-PB as a soft block. The mechanical properties and the microdeformation phenomena were mainly controlled by the nature of their solid-state morphology. Independent of morphology type, the soft phase was found to deform to a significantly higher degree of orientation when compared with the hard phase

Synthesis of NiPS3 and CoPS and its hydrogen storage capacity

International Nuclear Information System (INIS)

Ismail, N.; Madian, M.; El-Meligi, A.A.

2014-01-01

Highlights: • Preparation of NiPS 3 and CoPS using solid state reaction. • Characterization of compounds using XRD, TEM, SEM and IR. • Measuring the compounds thermal stability. • Estimation of the hydrogen storage capacity. -- Abstract: Prepared CoPS and NiPS 3 are studied as new materials for hydrogen energy storage. Single phase of CoPS and NiPS 3 were grown separately in evacuated silicatube via solid state reaction at 650 °C with controlled heating rate 1 °C/min. X-ray diffraction patterns confirm the formation of the desired compounds. Both CoPS and NiPS 3 exhibited high thermal stability up to 700 °C and 630 °C, respectively. The morphology of the prepared samples was investigated using scanning electron microscopy and folded sheets appeared in the transmission electron microscopy. The samples were exposed to 20 bar applied hydrogen pressure at 80 K. Both compounds appear to have feasible hydrogen storage capacity. CoPS was capable to adsorb 1.7 wt% while NiPS 3 storage capacity reached 1.2 wt%

The PrPS4 type structure and a filled variant: the compounds TbPS4 and LiEuPS4

International Nuclear Information System (INIS)

Joergens, S.; Alili, L.; Mewis, A.

2005-01-01

Colourless single crystals of TbPS 4 (a = 10.696(2), c = 19.053(4) Aa) were obtained by reaction of the elements (750 C; 30 h). The compound crystallizes with the PrPS 4 type structure (I4 1 /acd; Z = 16). The structure consists of isolated PS 4 tetrahedra each surrounded by four Tb 3+ cations. Both crystallographically different Tb 3+ cations are coordinated by eight sulfur atoms which are part of four PS 4 tetrahedra. Orange single crystals of LiEuPS 4 (a = 11.498(2), c = 19.882(4) Aa) were prepared by reaction of Eu and P with Li 2 S 4 (700 C; 20 h). The crystal structure corresponds to the PrPS 4 type, in which tubes running along [001] are occupied by Li atoms, which are surrounded by four S atoms in strongly distorted tetrahedra. LiS 4 and PS 4 tetrahedra are connected via common edges into alternating chains. (orig.)

Prediction of canine and premolar size using the widths of various permanent teeth combinations: A cross-sectional study

Directory of Open Access Journals (Sweden)

Kalasandhya Vanjari

2015-01-01

Full Text Available Aims: To suggest the best predictor/s for determining the mesio-distal widths (MDWs of canines (C and premolars (Ps, and propose regression equation/s for hitherto unreported population. Methods: Impressions of maxillary and mandibular arches were made for 201 children (100 boys and 101 girls; age range: 11–15 years who met the inclusion criteria and poured with dental stone. The maximum MDWs of all the permanent teeth were measured using digital vernier caliper. Thirty-three possible combinations (patterns of permanent maxillary and mandibular first molars, central and lateral incisors were framed and correlated with MDWs of C and Ps using Pearson correlation test. Results: There were significant correlations between the considered patterns and MDWs of C and Ps, with difference noted between girls (range of r: 0.34–0.66 and boys (range of r: 0.28–0.77. Simple linear and multiple regression equations for boys, girls, and combined sample were determined to predict MDW of C and Ps in both the arches. Conclusions: The accuracy of prediction improved considerably with the inclusion of as many teeth as possible in the regression equations. The newly proposed equations based on the erupted teeth may be considered clinically useful for space analysis in the considered population.

Generation of nanospikes via laser ablation of metals in liquid environment and their activity in surface-enhanced Raman scattering of organic molecules

Energy Technology Data Exchange (ETDEWEB)

Truong, S. Lau; Levi, G.; Bozon-Verduraz, F. [ITODYS, UMR-CNRS 7086, Universite Paris 7-Denis Diderot, 2, place Jussieu, 75251 Paris cedex 05 (France); Petrovskaya, A.V.; Simakin, A.V. [Wave Research Center of A.M. Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilov street, 119991 Moscow (Russian Federation); Shafeev, G.A. [Wave Research Center of A.M. Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilov street, 119991 Moscow (Russian Federation)], E-mail: shafeev@kapella.gpi.ru

2007-12-15

The formation of dense arrays of nanospikes occurs under laser ablation of bulk targets (Ag, Au, Ta, Ti) immersed in liquids such as water or ethanol. The average height of spikes is 50 nm and their density on the target amounts to 10{sup 10} cm{sup -2}. The effect is observed with sufficiently short laser pulses. In particular, either a 350 ps or a 90 ps Nd:YAG lasers are used in their fundamental harmonics. The nanospikes are characterized by UV-Visible reflection spectrometry and atomic force microscopy. The oscillations of electrons within nanospikes result in a permanent coloration of the surface and a modification of the optical reflection spectra of the metal. Scanning the laser beam along the metal surface allows its nanostructuring over extended areas ({approx}1 cm{sup 2}). The nanostructured Ag surface shows enhanced Raman scattering of acridine molecules at a concentration of 10{sup -5} M/l, whereas the initial Ag targets do not show any signal within the accuracy of measurements.

Diffuse scattering from laser-irradiated plane targets

International Nuclear Information System (INIS)

Kessel, C.G.M. van; Olsen, J.N.; Sachsenmaier, P.; Sigel, R.; Eidmann, K.; Godwin, R.P.

1976-11-01

Optical calorimetry of the laser radiation scattered from plane targets irradiated by 0.3 Joule/30 ps Nd-laser pulses with intensities up to 10 16 W cm -2 has been performed with an emphasis on diffuse scattering. Diffuse scattering outside the solid angle of the focusing lens is found to be a major reflection loss from the target. A fraction of 0.3 to 0.5 of the incident pulse energy was absorbed in the target with only a very weak dependence on pulse energy and target material. (orig.) [de

A fine adjustment mechanism of the second crystal in a double-crystal monochromator with a 3-PS parallel manipulator

International Nuclear Information System (INIS)

Cao Chongzhen; Gao, X.; Ma, P.; Yu, H.; Wang, F.; Huang, Y.; Liu, P.

2005-01-01

A novel fine adjustment mechanism of the second crystal in a double-crystal monochromator is put forward, which is based on a 3-PS parallel manipulator and the magnetic force. Not only is the principle of fine adjusting the pitch angle and the roll angle analyzed, but also optimization of the structure parameters of the permanent magnet, a key part of the fine adjustment mechanism. The fine adjustment mechanism with the 3-PS parallel manipulator has been applied successfully in the double-crystal monochromator of 4W1B beam line in the Beijing Synchrotron Radiation Facility (BSRF)

Caracterização viscosimétrica de nanocompósitos híbridos PS/POSS Viscometric characterization of PS/POSS hybrid nanocomposites

Directory of Open Access Journals (Sweden)

Otávio Bianchi

2012-01-01

Full Text Available Nanocompósitos híbridos de poliestireno (PS e poliedros oligoméricos silsesquioxanos (POSS com diferentes composições e graus de hibridização foram obtidos por processamento reativo no estado fundido utilizando-se peróxido de dicumila (DCP como iniciador, na presença ou não de estireno como agente de transferência de radical. Os materiais foram caracterizados viscosimetricamente por cromatografia de permeação em gel (GPC usando detecção tripla por espalhamento de luz, viscosimetria e índice de refração. As amostras PS/POSS processadas com estireno apresentaram maiores valores de massa molar ponderal média (Mw e menores valores de polidispersão (Mw/Mn, devido ao maior grau de conversão da reação de hibridização do PS-POSS (28-40% e do menor grau de degradação (cisão das cadeias do PS, quando comparadas com amostras PS/POSS processadas sem estireno nas quais o grau de conversão ficou em torno de 24-28%. Para os sistemas PS e PS/POSS em solução com THF, os parâmetros da equação de Mark-Houwink-Sakurada (MHS, α ≅ 0,7 e log K ≅ -3,5 a -3,9 e os valores dos parâmetros de interação polímero-solvente, χij ≅ 0,49, não apresentaram diferenças significativas com relação aos tamanhos moleculares. Por outro lado, essas diferenças de tamanhos moleculares foram caracterizadas por uma função cumulativa da fração mássica de cadeias em função da distância média quadrática entre pontas de cadeia (0½.Polystyrene (PS and polyhedral oligomeric silsesquioxanes (POSS hybrid nanocomposites with different compositions were obtained by reactive melt processing using dicumyl peroxide (DCP as initiator in the presence or absence of styrene as radical transfer agent. The materials were characterized by viscosimetry by means of gel permeation chromatography (GPC using triple-detector: light scattering, viscometer and refractive index. PS/POSS samples processed with styrene showed higher weight average molecular

Precise Geolocation Of Persistent Scatterers Aided And Validated By Lidar DSM

Science.gov (United States)

Chang, Ling; Dheenathayalan, Prabu; Hanessen, Ramon

2013-12-01

Persistent Scatterers (PS) interferometry results in the de- formation history of time-coherent scatterers. Although several applications focus on smooth, spatially correlated signals, we aim for the detection, identification and analysis of single anomalies. These targets can be indicative of, e.g., strain in structures, potentially leading to the failure of such structures. For the identification and analysis it is of the greatest importance to know the exact position of the effective scattering center, to avoid an improper interpretation of the driving mechanism. Here we present an approach to optimize the geolocation of important scatterers, when necessary aided by an a priori Lidar-derived DSM (AHN-1 data) with 15cm and 5m resolution in vertical and horizontal directions, respectively. The DSM is also used to validate the geocoding. We implement our approach on a near-collapse event of a shopping mall in Heerlen, the Netherlands, to generate the precise geolocation of local PS points.

Detailed calculations on low-energy positron-hydrogen-molecule and helium-antihydrogen scattering

Energy Technology Data Exchange (ETDEWEB)

Armour, E A G; Cooper, J N; Gregory, M R; Todd, A C [School of Mathematical Sciences, University of Nottingham, Nottingham NG7 2RD (United Kingdom); Jonsell, S [Department of Physics, University of Swansea, Swansea SA2 8PP (United Kingdom); Plummer, M, E-mail: edward.armour@nottingham.ac.u [Computational Science and Engineering, STFC Daresbury Laboratory, Warrington WA4 4AD (United Kingdom)

2010-01-01

In this paper, we consider two scattering processes: low-energy positron-hydrogen-molecule and helium-antihydrogen scattering. In the positron-hydrogen-molecule scattering calculations, we use the Kohn variational method to calculate Z{sub eff}, the number of target electrons available to the positron for annihilation. In the helium-antihydrogen scattering calculations, we use the Rayleigh-Ritz variational method to calculate a wave function for the leptons as a function of the distance between the helium and the antihydrogen. This is used, together with the associated nuclear wave function and the wave function for {alpha} p-bar + Ps{sup -}, to calculate the cross section for the rearrangement reaction He + H-bar {yields} {alpha} p-bar + Ps{sup -}, using the T-matrix and a form of the distorted wave approximation. For both processes, positron-electron correlation is taken into account accurately using Hylleraas-type functions.

Low-energy Scattering of Positronium by Atoms

Science.gov (United States)

Ray, Hasi

2007-01-01

The survey reports theoretical studies involving positronium (Ps) - atom scattering. Investigations carried out in last few decades have been briefly reviewed in this article. A brief description of close-coupling approximation (CCA), the first-Born approximation (FBA) and the Born-Oppenheimer approximation (BOA) for Ps-Atom systems are made. The CCA codes of Ray et a1 [1-6] are reinvestigated using very fine mesh-points to search for resonances. The article advocates the need for an extended basis set & a systematic study using CCAs.

Physics at the AD/PS/SPS - PLEASE NOTE CHANGE OF ROOM!(2/4)

CERN Multimedia

CERN. Geneva

2012-01-01

Lecture 2: QCD and hadron physics: COMPASS, NA61, DIRAC The lecture will discuss the research done at the COMPASS, SHINE and DIRAC experiments at the SPS and PS. COMPASS studies nucleon structure and hadron spectroscopy, SHINE searches for the critical point and onset of deconfinement in heavy ion collisions while DIRAC studies the pi-pi scattering length in pionic atoms.

Determination of grafting conversion degree in PS/PS-graft-POSS/POSS hybrid nanocomposites obtained through reactive processing

International Nuclear Information System (INIS)

Bianchi, Otavio; Repenning, Gustavo B.; Mauler, Raquel S.; Oliveira, Ricardo V.B.; Canto, Leonardo B.

2011-01-01

Hybrid nanocomposites of polystyrene (PS) and polyhedral oligomeric silsesquioxanes (POSS) - PS/PS-graft-POSS/POSS - with different grafting degrees were prepared by reactive melt processing using dicumyl peroxide (DCP) as initiator in the presence or absence of styrene monomer as radical transfer agent. Gel permeation chromatography (GPC) using triple-detector and proton nuclear magnetic resonance (NMR 1 H) analyses were used together to determine the conversion degree of PS-graft-POSS as a function of the reactive processing conditions adopted. GPC was employed to evaluate the effects of grafting (PS-graft-POSS) and PS chains degradation (β scission) that occur simultaneously during processing on the variation of average molecular masses and distributions for each PS/POSS sample. PS/POSS systems processed with styrene showed higher weight average molecular weights (M w ) and lower polydispersity indexes (M w /M n ), as a result of higher grafting (PS-graft-POSS) conversion (28-40%) and lower PS chain degradation level, as compared to PS/POSS systems processed without styrene in which the degree of grafting conversion was around 25-28%. (author)

Whipple Resection: Concordance Between Frozen Section And Permanent Section Diagnosis Of Surgical Margins.

Science.gov (United States)

Bilal, Muhammad; Tariq, Hina; Mamoon, Nadira

2018-01-01

Margin assessment is done in Whipple procedures which are usually performed to resect tumours of head of pancreas and ampullary/periampullary region. Aims and objective of the study are to determine the concordance between frozen sections (FS) and permanent sections (PS) of surgical margins in Whipple resections. It is a retrospective study, from January 2008 to January 2015 (07 years). It includes the specimen with malignancy in final report and for which FS of pancreatic and/or CBD margin(s) were requested. Data was retrieved from Laboratory information system (LIS) database. Of the 41 bile duct margins in cases of ampullary tumours, 03 were positive on FS as well as PS, 35 were negative on FS as well as on PS. Results showed 100% sensitivity, 92.1% specificity, 50% PPV and 100% NPV. Results of 36 pancreatic margins in cases of ampullary showed 100% sensitivity, 97.1% specificity, 50% PPV and 100% NPV. In pancreatic carcinoma cases, none of CBD margins were reported as positive on FS, 02 margins reported as negative were found positive on PS, while 17 were negative on FS as well as PS. Results showed 100% specificity and 89.5% NPV. Of the 27 pancreatic margins tested in pancreatic tumours 100% sensitivity, 94.1% specificity, 88.9% PPV and 100% NPV was found. Factors such as absent prior tissue diagnosis and/or inflammatory processes make margin diagnosis difficult. However, a high concordance was observed between our FS and PS diagnosis.

ps-ro Fuzzy Open(Closed Functions and ps-ro Fuzzy Semi-Homeomorphism

Directory of Open Access Journals (Sweden)

Pankaj Chettri

2015-11-01

Full Text Available The aim of this paper is to introduce and characterize some new class of functions in a fuzzy topological space termed as ps-ro fuzzy open(closed functions, ps-ro fuzzy pre semiopen functions and ps-ro fuzzy semi-homeomorphism. The interrelation among these concepts and also their relations with the parallel existing concepts are established. It is also shown with the help of examples that these newly introduced concepts are independent of the well known existing allied concepts.

Last PS magnet refurbished

CERN Multimedia

2009-01-01

PS Magnet Refurbishment Programme Completed. The 51st and final refurbished magnet was transported to the PS on Tuesday 3 February. The repair and consolidation work on the PS started back in 2003 when two magnets and a busbar connection were found to be faulty during routine high-voltage tests. The cause of the fault was a combination of age and radiation on electrical insulation. After further investigation the decision was taken to overhaul half of the PS’s 100 magnets to reduce the risk of a similar fault. As from 20 February the PS ring will start a five-week test programme to be ready for operation at the end of March.

Structural transition with thickness in films of poly-(styrene-b-2vinylpyridine) (PS-b-P2VP) diblock copolymer/homopolymer blends

Science.gov (United States)

Mishra, Vindhya; Kramer, Edward; Hur, Su-Mi; Fredrickson, Glenn; Sprung, Michael

2009-03-01

In multilayer thin films of spherical morphology block copolymers, the surface layers prefer hexagonal symmetry while the inner layers prefer BCC. Thin films with spherical morphology of PS-b-P2VP blends with short homopolymer polystyrene (hPS) chains have an HCP structure up to a thickness n* at which there is a transition to a face centered orthorhombic structure. Using grazing incidence small angle X-ray scattering and transmission electron microscopy we show that that n* increases from 5 to 9 with increase in hPS from 0 to 12 vol%. For thicknesses just below n* the HCP and FCO structures coexist, but on long annealing HCP prevails. We hypothesize that the PS segregates to the interstices in the HCP structure reducing the stretching of the PS blocks and the free energy penalty of HCP versus BCC inner layers. Self consistent field theoretic simulations are being carried out to see if this idea is correct.

Search for a permanent electric-dipole moment using atomic indium

International Nuclear Information System (INIS)

Sahoo, B. K.; Pandey, R.; Das, B. P.

2011-01-01

We propose indium (In) as a possible candidate for observing the permanent electric dipole moment (EDM) arising from violations of parity (P) and time-reversal (T) symmetries. This atom has been laser cooled and therefore the measurement of its EDM has the potential of improving on the current best EDM limit for a paramagnetic atom, which comes from thallium. We report the results of our calculations of the EDM enhancement factor due to the electron EDM and the ratio of the atomic EDM to the electron-nucleus scalar-pseudoscalar (S-PS) interaction coupling constant in In within the framework of the relativistic coupled cluster theory. It might be possible to get new limits for the electron EDM and the S-PS CP-violating coupling constant by combining the results of our calculations with the measured value of the EDM of In when it is available. These limits could have important implications for the standard model (SM) of particle physics.

Large-t elastic scattering and diffraction dissocation

International Nuclear Information System (INIS)

Timmermans, J.

1985-01-01

Recent results, both from the ISR and the S anti p pS Collider, on proton-antiproton elastic scattering at large values of the four-momentum transfer squared, are presented. The results are compared with predictions of several theoretical models of high-energy collisions. Single diffraction dissociation at the Collider is also discussed. (author)

Synthesis and Characterization of the Rubidium Thiophosphate Rb 6 (PS 5 )(P 2 S 10 ) and the Rubidium Silver Thiophosphates Rb 2 AgPS 4 , RbAg 5 (PS 4 ) 2 and Rb 3 Ag 9 (PS 4 ) 4

KAUST Repository

Alahmary, Fatimah S.; Davaasuren, Bambar; Khanderi, Jayaprakash; Rothenberger, Alexander

2016-01-01

The metal thiophosphates Rb2AgPS4 (2), RbAg5(PS4)2 (3), and Rb3Ag9(PS4)4 (4) were synthesized by stoichiometric reactions, whereas Rb6(PS5)(P2S10) (1) was prepared with excess amount of sulfur. The compounds crystallize as follows: 1 monoclinic, P21

Gamma-induced Positron Spectroscopy (GiPS) at a superconducting electron linear accelerator

International Nuclear Information System (INIS)

Butterling, Maik; Anwand, Wolfgang; Cowan, Thomas E.; Hartmann, Andreas; Jungmann, Marco; Krause-Rehberg, Reinhard; Krille, Arnold; Wagner, Andreas

2011-01-01

A new and unique setup for Positron Annihilation Spectroscopy has been established and optimized at the superconducting linear electron accelerator ELBE at Helmholtz-Zentrum Dresden-Rossendorf (Germany). The intense, pulsed (26 MHz) photon source (bremsstrahlung with energies up to 16 MeV) is used to generate positrons by means of pair production throughout the entire sample volume. Due to the very short gamma bunches (< 5 ps temporal length), the facility for Gamma-induced Positron Spectroscopy (GiPS) is suitable for positron lifetime spectroscopy using the accelerator's radiofrequency as time reference. Positron lifetime and Doppler broadening Spectroscopy are employed by a coincident measurement (Age-Momentum Correlation) of the time-of-arrival and energy of the annihilation photons which in turn significantly reduces the background of scattered photons resulting in spectra with high signal to background ratios. Simulations of the setup using the GEANT4 framework have been performed to yield optimum positron generation rates for various sample materials and improved background conditions.

Gamma-induced Positron Spectroscopy (GiPS) at a superconducting electron linear accelerator

Energy Technology Data Exchange (ETDEWEB)

Butterling, Maik, E-mail: maik.butterling@googlemail.com [Martin-Luther University, Dept. of Physics, 06099 Halle (Germany); Institute of Radiation Physics, Helmholtz-Zentrum, Dresden-Rossendorf, P.O. Box 510119, 01314 Dresden (Germany); Anwand, Wolfgang; Cowan, Thomas E.; Hartmann, Andreas [Institute of Radiation Physics, Helmholtz-Zentrum, Dresden-Rossendorf, P.O. Box 510119, 01314 Dresden (Germany); Jungmann, Marco; Krause-Rehberg, Reinhard [Martin-Luther University, Dept. of Physics, 06099 Halle (Germany); Krille, Arnold; Wagner, Andreas [Institute of Radiation Physics, Helmholtz-Zentrum, Dresden-Rossendorf, P.O. Box 510119, 01314 Dresden (Germany)

2011-11-15

A new and unique setup for Positron Annihilation Spectroscopy has been established and optimized at the superconducting linear electron accelerator ELBE at Helmholtz-Zentrum Dresden-Rossendorf (Germany). The intense, pulsed (26 MHz) photon source (bremsstrahlung with energies up to 16 MeV) is used to generate positrons by means of pair production throughout the entire sample volume. Due to the very short gamma bunches (< 5 ps temporal length), the facility for Gamma-induced Positron Spectroscopy (GiPS) is suitable for positron lifetime spectroscopy using the accelerator's radiofrequency as time reference. Positron lifetime and Doppler broadening Spectroscopy are employed by a coincident measurement (Age-Momentum Correlation) of the time-of-arrival and energy of the annihilation photons which in turn significantly reduces the background of scattered photons resulting in spectra with high signal to background ratios. Simulations of the setup using the GEANT4 framework have been performed to yield optimum positron generation rates for various sample materials and improved background conditions.

Analysis of Order Formation in Block Copolymer Thin Films UsingResonant Soft X-Ray Scattering

Energy Technology Data Exchange (ETDEWEB)

Virgili, Justin M.; Tao, Yuefei; Kortright, Jeffrey B.; Balsara,Nitash P.; Segalman, Rachel A.

2006-11-27

The lateral order of poly(styrene-block-isoprene) copolymer(PS-b-PI) thin films is characterized by the emerging technique ofresonant soft X-ray scattering (RSOXS) at the carbon K edge and comparedto ordering in bulk samples of the same materials measured usingconventional small-angle X-ray scattering. We show resonance using theoryand experiment that the loss of scattering intensity expected with adecrease in sample volume in the case of thin films can be overcome bytuning X-rays to the pi* resonance of PS or PI. Using RSOXS, we study themicrophase ordering of cylinder- and phere-forming PS-b-PI thin films andcompare these results to position space data obtained by atomic forcemicroscopy. Our ability to examine large sample areas (~;9000 mu m2) byRSOXS enables unambiguous identification of the lateral lattice structurein the thin films. In the case of the sphere-forming copolymer thin film,where the spheres are hexagonally arranged, the average sphere-to-spherespacing is between the bulk (body-centered cubic) nearest neighbor andbulk unit cell spacings. In the case of the cylinder-forming copolymerthin film, the cylinder-to-cylinder spacing is within experimental errorof that obtained in the bulk.

Time resolved resonant inelastic X-ray scattering: A supreme tool to understand dynamics in solids and molecules

International Nuclear Information System (INIS)

Beye, M.; Wernet, Ph.; Schüßler-Langeheine, C.; Föhlisch, A.

2013-01-01

Highlights: •The high specificity of RIXS ideally suits time-resolved measurements. •Methods relating to the core hole lifetime cover the low femtosecond regime. •Pump-probe methods are used starting at sub-ps time scales. •FELs and synchrotrons are useful for pump-probe studies. •Examples from solid state dynamics and molecules are discussed. -- Abstract: Dynamics in materials typically involve different degrees of freedom, like charge, lattice, orbital and spin in a complex interplay. Time-resolved resonant inelastic X-ray scattering (RIXS) as a highly selective tool can provide unique insight and follow the details of dynamical processes while resolving symmetries, chemical and charge states, momenta, spin configurations, etc. In this paper, we review examples where the intrinsic scattering duration time is used to study femtosecond phenomena. Free-electron lasers access timescales starting in the sub-ps range through pump-probe methods and synchrotrons study the time scales longer than tens of ps. In these examples, time-resolved resonant inelastic X-ray scattering is applied to solids as well as molecular systems

Using Lattice Topology Information to Investigate Persistent Scatterers at Facades in Urban Areas

Science.gov (United States)

Schack, L.; Soergel, U.

2013-05-01

Modern spaceborne SAR sensors like TerraSAR-X offer ground resolution of up to one meter in range and azimuth direction. Buildings, roads, bridges, and other man-made structures appear in such data often as regular patterns of strong and temporally stable points (Persistent Scatterer, PS). As one step in the process of unveiling what object structure actually causes the PS (i.e., physical nature) we compare those regular structures in SAR data to their correspondences in optical imagery. We use lattices as a common data representation for visible facades. By exploiting the topology information given by the lattices we can complete gaps in the structures which is one step towards the understanding of the complex scattering characteristics of distinct facade objects.

Ionic Salt Effect on the Phase Transition of PS-b-P2VP Copolymers

Science.gov (United States)

Kim, Bokyung; An, Hyungju; Ryu, Du Yeol; Kim, Jehan

2009-03-01

Solid-state electrolytes have long been considered as suitable candidates owing to the simple and easy processes for rechargeable battery manufactures, compared to conventional liquid electrolyte counterparts. Especially, polymer/salt systems involving PMMA and PVP complex forms have been studied since they provide stable electrochemical characteristics as well as mechanical properties. We studied the phase behavior of PS-b-P2VP upon the salt addition by small angle x-ray scattering (SAXS) and depolarized light scattering. Transition temperatures of block copolymer were significantly influenced by the salt addition in addition to the changes of d-spacings, which is caused by the effective coordinative interaction between P2VP block and salt. This study suggests a simple approach to solid-state block copolymer electrolytes.

PS Booster - Festive colloquium

CERN Multimedia

2012-01-01

A festive colloquium will be held to celebrate the 40th anniversary of the PS Booster on Friday, 28 September at 2 p.m. in the CERN council chamber. The meeting will be open to everybody. Read more on the PS Booster in the CERN Bulletin and in the CERN Courier.

Symmetry of dipositronium Ps2

International Nuclear Information System (INIS)

Schrader, D.M.

2004-01-01

We work out the complete symmetry and spin problem for diatomic positronium Ps 2 for the ground and singly excited states of zero orbital angular momentum. The general form of the wave function for each state is given, with due regard to charge conjugation parity. Annihilation rates are discussed, and correlations to dissociation products are deduced. We indicate how the approach is extensible to larger aggregates: i.e., PsPs n , n>2

Using PS-InSAR to detect surface deformation in geothermal areas of West Java in Indonesia

Science.gov (United States)

Maghsoudi, Yasser; van der Meer, Freek; Hecker, Christoph; Perissin, Daniele; Saepuloh, Asep

2018-02-01

In this paper, the Persistent Scatterer InSAR (PS-InSAR) technique is applied in order to investigate the ground deformation in and around two geothermal areas in West Java, Indonesia. Two time-series of ALOS PALSAR and Sentinel-1A acquisitions, covering the period from 2007 to 2009 and 2015-2016, are analysed. The first case study examines the Wayang Windu geothermal zone where the PS-InSAR analysis provides an overview of the surface deformation around a geothermal reservoir. Uplift is observed around the injection wells in the area. The second example involves the use of the PS-InSAR technique over a more recent geothermal system in Patuha field. Again, a pattern of uplift was observed around the only available injection well in the area. Due to the dense vegetation coverage of the geothermal areas in West Java, the longer wavelength ALOS PALSAR data is provides better results by identifying a larger number of PS points. Additionally, experiments have been carried out to compare the resulting deformation with another example of the fluid migration process i.e. water extraction in Bandung basin. The potential of sentinel-1A and ALOS PALSR data are compared in all the experiments.

Slow Noncollinear Coulomb Scattering in the Vicinity of the Dirac Point in Graphene.

Science.gov (United States)

König-Otto, J C; Mittendorff, M; Winzer, T; Kadi, F; Malic, E; Knorr, A; Berger, C; de Heer, W A; Pashkin, A; Schneider, H; Helm, M; Winnerl, S

2016-08-19

The Coulomb scattering dynamics in graphene in energetic proximity to the Dirac point is investigated by polarization resolved pump-probe spectroscopy and microscopic theory. Collinear Coulomb scattering rapidly thermalizes the carrier distribution in k directions pointing radially away from the Dirac point. Our study reveals, however, that, in almost intrinsic graphene, full thermalization in all directions relying on noncollinear scattering is much slower. For low photon energies, carrier-optical-phonon processes are strongly suppressed and Coulomb mediated noncollinear scattering is remarkably slow, namely on a ps time scale. This effect is very promising for infrared and THz devices based on hot carrier effects.

Psychometric properties of the OARSI/OMERACT osteoarthritis pain and functional impairment scales: ICOAP, KOOS-PS and HOOS-PS.

Science.gov (United States)

Ruyssen-Witrand, A; Fernandez-Lopez, C J; Gossec, L; Anract, P; Courpied, J P; Dougados, M

2011-01-01

To evaluate the psychometric properties of the OARSI-OMERACT questionnaires in comparison to the existing validated scales. Consecutive hip or knee osteoarthritis patients consulting in an orthopedic department were enrolled in the study. Data collected were pain using the Intermittent and Constant Osteoarthritis Pain (ICOAP), a Numeric Rating Scale (NRS), the Western Ontario McMaster Universities' Osteoarthritis Index (WOMAC) pain subscale, the Lequesne pain subscale; functional impairment using the Knee disability and Osteoarthritis Outcome Score-Physical Function Shortform (KOOS-PS), the Hip disability and Osteoarthritis Outcome Score-Physical Function Shortform (HOOS-PS), a NRS, the WOMAC function sub-scale, the Lequesne function subscale. Validity was assessed by calculating the Spearman's correlation coefficient between all the scales. Reliability was assessed in out-patients with stable disease comparing the data collected within 2 weeks using the intra-class correlation coefficient (ICC). Responsiveness was assessed on the data from hospitalised patients prior to and 12 weeks after a total joint replacement (TJR) using the standardised response mean. Three hundred patients (mean age=68 years, females=62%, hip OA=57%) were included. There was a moderate to good correlation between ICOAP, KOOS-PS, HOOS-PS and the WOMAC, NRS and Lequesne scales. Reliability of the ICOAP hip OA HOOS-PS and KOOS-PS was good (ICC range 0.80-0.81) whereas it was moderate for knee ICOAP (ICC=0.65). Responsiveness of the ICOAP, KOOS-PS and HOOS-PS 12 weeks after TJR was comparable to responsiveness of other scales (SRM range: 0.54-1.82). The psychometric properties of the ICOAP, KOOS-PS and HOOS-PS were comparable to those of the WOMAC, Lequesne and NRS.

Expectation values of the e+PsH system

International Nuclear Information System (INIS)

Zhang, J.-Y.; Mitroy, J.

2007-01-01

Close to converged energies and expectation values for e + PsH are computed using a ground-state wave function consisting of 1500 explicitly correlated Gaussians. The best estimate of the e + PsH ∞ energy was -0.810 254 hartrees, which has a binding energy of 0.021 057 hartrees against dissociation into e + +PsH. The 2γ annihilation rate was 2.7508x10 9 s -1 . Binding energies and annihilation rates are also given for the different finite-mass variants of e + PsH. Comparisons between expectation values for e + PsH and PsH provide compelling evidence that the e + PsH ground state can be regarded as consisting of a weakly bound positron orbiting the PsH ground state

Change Detection Based on Persistent Scatterer Interferometry - a New Method of Monitoring Building Changes

Science.gov (United States)

Yang, C. H.; Kenduiywo, B. K.; Soergel, U.

2016-06-01

Persistent Scatterer Interferometry (PSI) is a technique to detect a network of extracted persistent scatterer (PS) points which feature temporal phase stability and strong radar signal throughout time-series of SAR images. The small surface deformations on such PS points are estimated. PSI particularly works well in monitoring human settlements because regular substructures of man-made objects give rise to large number of PS points. If such structures and/or substructures substantially alter or even vanish due to big change like construction, their PS points are discarded without additional explorations during standard PSI procedure. Such rejected points are called big change (BC) points. On the other hand, incoherent change detection (ICD) relies on local comparison of multi-temporal images (e.g. image difference, image ratio) to highlight scene modifications of larger size rather than detail level. However, image noise inevitably degrades ICD accuracy. We propose a change detection approach based on PSI to synergize benefits of PSI and ICD. PS points are extracted by PSI procedure. A local change index is introduced to quantify probability of a big change for each point. We propose an automatic thresholding method adopting change index to extract BC points along with a clue of the period they emerge. In the end, PS ad BC points are integrated into a change detection image. Our method is tested at a site located around north of Berlin main station where steady, demolished, and erected building substructures are successfully detected. The results are consistent with ground truth derived from time-series of aerial images provided by Google Earth. In addition, we apply our technique for traffic infrastructure, business district, and sports playground monitoring.

Sequence control of phase separation and dewetting in PS/PVME blend thin films by changing molecular weight of PS.

Science.gov (United States)

Xia, Tian; Qin, Yaping; Huang, Yajiang; Huang, Ting; Xu, Jianhui; Li, Youbing

2016-11-28

The morphology evolution mechanism of polystyrene (PS)/poly (vinyl methyl ether) (PVME) blend thin films with different PS molecular weights (M w ) was studied. It was found that the morphology evolution was closely related to the molecular weight asymmetry between PS and PVME. In the film where M w (PS) ≈ M w (PVME), dewetting happened at the interface between the bottom layer and substrate after SD phase separation. While in the film where M w (PS) > M w (PVME), dewetting happened at the interface between the middle PS/PVME blend layer and bottom PVME layer near the substrate prior to phase separation. The different sequences of phase separation and dewetting and different interface for dewetting occurrence were studied by regarding the competitive effects of viscoelasticity contrast between polymer components and preferential wetting between PVME and the substrate. The viscoelastic nature of the PS component played a crucial role in the sequence of phase separation and dewetting.

Electron scattering from the octupole band in 238U

International Nuclear Information System (INIS)

Hirsch, A.; Creswell, C.; Bertozzi, W.; Heisenberg, J.; Hynes, M.V.; Kowalski, S.; Miska, H.; Norum, B.; Rad, F.N.; Sargent, C.P.; Sasanuma, T.; Turchinetz, W.

1978-01-01

A simple model for nuclear surface vibrations in permanently deformed nuclei does well in reproducing electron scattering cross sections of rotational levels built on a K/sup π/= 0 - intrinsic octupole vibration in 238 U

Permanent magnetic ferrite based power-tunable metamaterials

Science.gov (United States)

Zhang, Guanqiao; Lan, Chuwen; Gao, Rui; Zhou, Ji

2017-08-01

Power-tunable metamaterials based on barium permanent magnetic ferrite have been proposed and fabricated in this research. Scattering parameter measurements confirm a shift in resonant frequency in correlation to changes in incident electromagnetic power within microwave frequency band. The tunable phenomenon represented by a blue-shift in transmission spectra in the metamaterials array can be attributed to a decrease in saturation magnetization resulting from FMR-induced temperature elevation upon resonant conditions. This power-dependent behavior offers a simple and practical route towards dynamically fine-tunable ferrite metamaterials.

Electron Spin Resonance studies on PS, PP and PS/PP blends under gamma irradiation

International Nuclear Information System (INIS)

Reyes, J.; Claro, M.; Albano, C.; Venezuela Central University, Caracas; Moronta, D.

2002-01-01

Complete text of publication follows. Electron Spin Resonance (ESR) studies on Polystyrene (PS), Polypropylene (PP) and their mixtures at compositions of 80/20 with and without a compatibilizer (SBS in block), 7.5 wt.%, irradiated with gamma rays from a Cobalt-60 source with a dose rate of 4.8 KGy/h at integral doses of radiation of 10, 25, 50, 60, 70, 400, 800 and 1300 KGy in the presence of air and at room temperature (RT) are reported. The dependence of resonance line width, Hpp; resonance line shapes K, and radical concentration, S, with the integral dose of irradiation is investigated. The nature of the free radicals after ten days of air storage is discussed. The free radical concentration, the double integral of the resonance line, S, has been estimated at room temperature, RT, for a group of single lines, characterized by the same giromagnetic, g, value by direct numerical double integration. In the samples studied no spectrum of 0 kGy of integral dose was observed. The concentration of radicals, S, observed when the integral radiation doses was increased, presents a maximum value in the PP samples at high doses (70-1300 kGy) and minimum values in the PS samples with the same doses. This shows that the PP degrades at a faster rate than the PS, owing to the presence of the bencenic ring in the latter. In the PS/PP mixtures studied with and without compatibilizer, the values of the radical concentration is found between the observed values in the homopolymers, being closer to the PS, which might imply that the presence of PS decays the degradation process of the PP in the mixture

Cs0.49NbPS6

Directory of Open Access Journals (Sweden)

Hoseop Yun

2011-01-01

Full Text Available The quaternary thiophosphate, Cs0.49NbPS6, caesium hexathioniobiophosphate(V, has been synthesized by the reactive halide flux method. The title compound is isotypic with Rb0.46TaPS6 and is made up of a bicapped trigonal–biprismatic [Nb2S12] unit and a tetrahedral [PS4] group. The [Nb2S12] units linked by the [PS4] tetrahedra form infinite chains, yielding a three-dimensional network with rather large van der Waals gaps along the c axis in which the disordered Cs+ ions reside. The electrons released by the Cs atoms are transferred to the pairwise niobium metal site and there are substantial intermetallic Nb—Nb bonding interactions. This leads to a significant decrease of the intermetallic distance in the title compound compared to that in TaPS6. The classical charge balance of the title compound may be represented as [Cs+]0.49[Nb4.51+][P5+][S2−]4[S22−].

CHANGE DETECTION BASED ON PERSISTENT SCATTERER INTERFEROMETRY – A NEW METHOD OF MONITORING BUILDING CHANGES

Directory of Open Access Journals (Sweden)

C. H. Yang

2016-06-01

Full Text Available Persistent Scatterer Interferometry (PSI is a technique to detect a network of extracted persistent scatterer (PS points which feature temporal phase stability and strong radar signal throughout time-series of SAR images. The small surface deformations on such PS points are estimated. PSI particularly works well in monitoring human settlements because regular substructures of man-made objects give rise to large number of PS points. If such structures and/or substructures substantially alter or even vanish due to big change like construction, their PS points are discarded without additional explorations during standard PSI procedure. Such rejected points are called big change (BC points. On the other hand, incoherent change detection (ICD relies on local comparison of multi-temporal images (e.g. image difference, image ratio to highlight scene modifications of larger size rather than detail level. However, image noise inevitably degrades ICD accuracy. We propose a change detection approach based on PSI to synergize benefits of PSI and ICD. PS points are extracted by PSI procedure. A local change index is introduced to quantify probability of a big change for each point. We propose an automatic thresholding method adopting change index to extract BC points along with a clue of the period they emerge. In the end, PS ad BC points are integrated into a change detection image. Our method is tested at a site located around north of Berlin main station where steady, demolished, and erected building substructures are successfully detected. The results are consistent with ground truth derived from time-series of aerial images provided by Google Earth. In addition, we apply our technique for traffic infrastructure, business district, and sports playground monitoring.

SPS and PS Experiments Committee

CERN Multimedia

CERN. Geneva

2004-01-01

OPEN SESSION: 09:00 Status report of NA58 / COMPASS: A. Magnon 09:40 Status report of PS212 / DIRAC: L. Tausher 10:10 PS212 / DIRAC Addendum: L. Nemenov CLOSED SESSION on Tuesday, 27 April 2004 after the open session, Main Building, 6th floor conference room

Information extraction from dynamic PS-InSAR time series using machine learning

Science.gov (United States)

van de Kerkhof, B.; Pankratius, V.; Chang, L.; van Swol, R.; Hanssen, R. F.

2017-12-01

Due to the increasing number of SAR satellites, with shorter repeat intervals and higher resolutions, SAR data volumes are exploding. Time series analyses of SAR data, i.e. Persistent Scatterer (PS) InSAR, enable the deformation monitoring of the built environment at an unprecedented scale, with hundreds of scatterers per km2, updated weekly. Potential hazards, e.g. due to failure of aging infrastructure, can be detected at an early stage. Yet, this requires the operational data processing of billions of measurement points, over hundreds of epochs, updating this data set dynamically as new data come in, and testing whether points (start to) behave in an anomalous way. Moreover, the quality of PS-InSAR measurements is ambiguous and heterogeneous, which will yield false positives and false negatives. Such analyses are numerically challenging. Here we extract relevant information from PS-InSAR time series using machine learning algorithms. We cluster (group together) time series with similar behaviour, even though they may not be spatially close, such that the results can be used for further analysis. First we reduce the dimensionality of the dataset in order to be able to cluster the data, since applying clustering techniques on high dimensional datasets often result in unsatisfying results. Our approach is to apply t-distributed Stochastic Neighbor Embedding (t-SNE), a machine learning algorithm for dimensionality reduction of high-dimensional data to a 2D or 3D map, and cluster this result using Density-Based Spatial Clustering of Applications with Noise (DBSCAN). The results show that we are able to detect and cluster time series with similar behaviour, which is the starting point for more extensive analysis into the underlying driving mechanisms. The results of the methods are compared to conventional hypothesis testing as well as a Self-Organising Map (SOM) approach. Hypothesis testing is robust and takes the stochastic nature of the observations into account

Psühhodramaatikud annavad Pärnus eksami

Index Scriptorium Estoniae

2008-01-01

29. maist kuni 1. juunini kestab Pärnus psühhodraama konverents "Geeniuste kohtumine", kus rahvusvahelise koolituse läbinud annavad eksami. Ruuda Palmquist on psühhodraama kui teadusharu rajajaid Eestis. Pärnus on kohal Rootsi Moreno Instituudi juhataja, psühhodraama lavastaja Marc Treadwell

LEADIR-PS: providing unprecedented SMR safety and economics

Energy Technology Data Exchange (ETDEWEB)

Hart, R.S., E-mail: N2i2@xplornet.ca [Northern Nuclear Industries Incorporated, Cambridge, ON (Canada)

2015-07-01

Northern Nuclear Industries Incorporated (N{sup 2} I{sup 2}) is developing Small Modular Reactors (SMRs) called LEADIR-PS, an acronym for LEAD-cooled Integral Reactor-Passively Safe. LEADIR-PS integrates proven technologies including TRISO fuel, Pebble Bed core and graphite moderator, with molten lead coolant in an integral pool type reactor configuration to achieve unprecedented safety and economics. Plants under development are LEADIR-PS30, producing 30 MWth, LEADIR-PS100 producing 100 MWth and LEADIR-PS300 producing 300 MWth that are focused on serving the energy demands of areas with a small electrical grid and/or process heat applications. A plant consisting of six LEADIR-PS300 reactor modules serving a common turbine-generator, called the LEADIR-PS Six-Pack, is focused on serving areas with higher energy demands and a robust electricity grid. The Gen{sup +} I LEADIR-PS plants are inherently/passively safe. There is no potential for a Loss Of Coolant Accident, a reactivity transient without shutdown, a loss of heat sink, or hydrogen generation. No active systems or operator actions are required to assure safety. The unprecedented safety of LEADIR-PS reactors avoids large exclusion radius and demanding evacuation plan requirements. LEADIR-PS, with steam conditions of 370 {sup o}C and 12 MPa can serve over 85% of the world's non-transportation process heat demands. In Canada, the electricity and process heat demands, ranging from those of remote communities and the oil sands to densely populated areas can be served by LEADIR-PS. (author)

Permanent magnetic ferrite based power-tunable metamaterials

Energy Technology Data Exchange (ETDEWEB)

Zhang, Guanqiao; Lan, Chuwen [State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084 (China); Gao, Rui [High Temperature Thermochemistry Laboratory, Department of Mining and Materials Engineering, McGill University, Montreal, Quebec H3A 0C5 (Canada); Zhou, Ji, E-mail: zhouji@tsinghua.edu.cn [State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084 (China)

2017-08-15

Highlights: • Power-tunable metamaterials based on barium permanent magnetic ferrite have been proposed and fabricated. • It is observed that resonant frequency of the array shifts upon altering the output power. • This kind of power-tunable behavior is due to the temperature rise as a result of FMR-induced heat buildup. • This work offers a practical idea to tune ferrite metamaterials besides magneto-tunability and thermal-tunability. - Abstract: Power-tunable metamaterials based on barium permanent magnetic ferrite have been proposed and fabricated in this research. Scattering parameter measurements confirm a shift in resonant frequency in correlation to changes in incident electromagnetic power within microwave frequency band. The tunable phenomenon represented by a blue-shift in transmission spectra in the metamaterials array can be attributed to a decrease in saturation magnetization resulting from FMR-induced temperature elevation upon resonant conditions. This power-dependent behavior offers a simple and practical route towards dynamically fine-tunable ferrite metamaterials.

Magnetic inelastic scattering: Present results and future trends

Energy Technology Data Exchange (ETDEWEB)

Osborn, R.

1996-04-01

Experience over the last 15 years has shsown that pulsed neutron spectrometers are able to contribute to the field of magnetic inelastic scattering. Such spectrometers have high resolution and wide dynamic range, both of which are necessary in order to characterize the magnetic response of the complex systems of current interest, ranging from rare earth-transition metal permanent magnets to quantum critical scatterers. Howevera, all these studies have been constrained by current flux limitations. The development of more powerful spallation neutron sources, such as the JHP, is likely to transform these interesting demonstrations of the potential of pulsed neutron scattering into routine tools for the study of magnetic correlations.

Two-year survival rates of anti-TNF-α therapy in psoriatic arthritis (PsA) patients with either polyarticular or oligoarticular PsA.

Science.gov (United States)

Iannone, F; Lopriore, S; Bucci, R; Scioscia, C; Anelli, M G; Notarnicola, A; Lapadula, G

2015-05-01

To evaluate the 2-year drug survival rates of the tumour necrosis factor (TNF)-α blockers adalimumab, etanercept, and infliximab in psoriatic arthritis (PsA) patients with either oligoarticular (oligo-PsA) or polyarticular PsA (poly-PsA). We studied a prospective cohort of 328 PsA patients with peripheral arthritis (213 with poly-PsA and 115 with oligo-PsA), beginning their first ever anti-TNF-α treatment with adalimumab, etanercept, or infliximab. The aim of the study was to evaluate the drug survival rates and possible baseline predictors at 2 years. After 24 months, persistence in therapy with the first anti-TNF-α blocker was not statistically different in the oligo-PsA (70.4%) and poly-PsA (65.7%) subsets. Predictors of drug discontinuation were female sex [hazard ratio (HR) 1.63, 95% confidence interval (CI) 1.00-2.68, p = 0.04] and starting the therapy in years 2003-8 (HR 0.51, 95% CI 0.33-0.80, p = 0.003). In poly-PsA, the persistence of etanercept (68.3%) was significantly higher than that of adalimumab (51.9%, p = 0.01), whereas in oligo-PsA no significant difference was detected. In poly-PsA, the period 2003-8 was a negative predictor (HR 0.36, 95% CI 0.21-0.62, p = 0.0001) whereas in oligo-PsA female gender was a positive predictor of drug discontinuation (HR 2.08, 95% CI 1.02-4.24, p = 0.04). With regard to clinical outcomes, the best responses in terms of European League Against Rheumatism (EULAR) 'good' response or Disease Activity Score (DAS28) remission, crude or adjusted according to the LUND Efficacy indeX (LUNDEX), were seen in patients on etanercept or infliximab. Our study provides some evidence that anti-TNF-α drugs may perform differently in PsA, and that the analysis of clinical disease subsets may improve our knowledge and promote better management of PsA.

Updating the Psoriatic Arthritis (PsA) Core Domain Set: A Report from the PsA Workshop at OMERACT 2016.

Science.gov (United States)

Orbai, Ana-Maria; de Wit, Maarten; Mease, Philip J; Callis Duffin, Kristina; Elmamoun, Musaab; Tillett, William; Campbell, Willemina; FitzGerald, Oliver; Gladman, Dafna D; Goel, Niti; Gossec, Laure; Hoejgaard, Pil; Leung, Ying Ying; Lindsay, Chris; Strand, Vibeke; van der Heijde, Désirée M; Shea, Bev; Christensen, Robin; Coates, Laura; Eder, Lihi; McHugh, Neil; Kalyoncu, Umut; Steinkoenig, Ingrid; Ogdie, Alexis

2017-10-01

To include the patient perspective in accordance with the Outcome Measures in Rheumatology (OMERACT) Filter 2.0 in the updated Psoriatic Arthritis (PsA) Core Domain Set for randomized controlled trials (RCT) and longitudinal observational studies (LOS). At OMERACT 2016, research conducted to update the PsA Core Domain Set was presented and discussed in breakout groups. The updated PsA Core Domain Set was voted on and endorsed by OMERACT participants. We conducted a systematic literature review of domains measured in PsA RCT and LOS, and identified 24 domains. We conducted 24 focus groups with 130 patients from 7 countries representing 5 continents to identify patient domains. We achieved consensus through 2 rounds of separate surveys with 50 patients and 75 physicians, and a nominal group technique meeting with 12 patients and 12 physicians. We conducted a workshop and breakout groups at OMERACT 2016 in which findings were presented and discussed. The updated PsA Core Domain Set endorsed with 90% agreement by OMERACT 2016 participants included musculoskeletal disease activity, skin disease activity, fatigue, pain, patient's global assessment, physical function, health-related quality of life, and systemic inflammation, which were recommended for all RCT and LOS. These were important, but not required in all RCT and LOS: economic cost, emotional well-being, participation, and structural damage. Independence, sleep, stiffness, and treatment burden were on the research agenda. The updated PsA Core Domain Set was endorsed at OMERACT 2016. Next steps for the PsA working group include evaluation of PsA outcome measures and development of a PsA Core Outcome Measurement Set.

The PS Booster hits 40

CERN Multimedia

Joannah Caborn Wengler

2012-01-01

Many accelerators’ "round" birthdays are being celebrated at CERN these days – the PS turned 50 in 2009, the SPS was 35 in 2011, and this year it's the turn of the PS Booster to mark its 40th anniversary. Originally designed to accelerate 1013 protons to 800 MeV, it has far exceeded its initial design performance over the years.   The PS Booster in the 1970s. Imagine the scene: a group of accelerator physicists staring expectantly at a monitor, when suddenly a shout of joy goes up as a signal flickers across the screen. Does that sound familiar? Well, turn the clock back 40 years (longer hair, wider trouser legs) and you have the situation at the PS Booster on 26 May 1972. On that day, beam was injected into the Booster for the first time. “It was a real buzz,” says Heribert Koziol, then Chairman of the Running-in Committee. “We were very happy – and also a little relieved – when the beam finally...

The PS locomotive runs again

CERN Multimedia

2001-01-01

Over forty years ago, the PS train entered service to steer the magnets of the accelerator into place... ... a service that was resumed last Tuesday. Left to right: Raymond Brown (CERN), Claude Tholomier (D.B.S.), Marcel Genolin (CERN), Gérard Saumade (D.B.S.), Ingo Ruehl (CERN), Olivier Carlier (D.B.S.), Patrick Poisot (D.B.S.), Christian Recour (D.B.S.). It is more than ten years since people at CERN heard the rumbling of the old PS train's steel wheels. Last Tuesday, the locomotive came back into service to be tested. It is nothing like the monstrous steel engines still running on conventional railways -just a small electric battery-driven vehicle employed on installing the magnets for the PS accelerator more than 40 years ago. To do so, it used the tracks that run round the accelerator. In fact, it is the grandfather of the LEP monorail. After PS was commissioned in 1959, the little train was used more and more rarely. This is because magnets never break down, or hardly ever! In fact, the loc...

Urban Monitoring Based on SENTINEL-1 Data Using Permanent Scatterer Interferometry and SAR Tomography

Science.gov (United States)

Crosetto, M.; Budillon, A.; Johnsy, A.; Schirinzi, G.; Devanthéry, N.; Monserrat, O.; Cuevas-González, M.

2018-04-01

A lot of research and development has been devoted to the exploitation of satellite SAR images for deformation measurement and monitoring purposes since Differential Interferometric Synthetic Apertura Radar (InSAR) was first described in 1989. In this work, we consider two main classes of advanced DInSAR techniques: Persistent Scatterer Interferometry and Tomographic SAR. Both techniques make use of multiple SAR images acquired over the same site and advanced procedures to separate the deformation component from the other phase components, such as the residual topographic component, the atmospheric component, the thermal expansion component and the phase noise. TomoSAR offers the advantage of detecting either single scatterers presenting stable proprieties over time (Persistent Scatterers) and multiple scatterers interfering within the same range-azimuth resolution cell, a significant improvement for urban areas monitoring. This paper addresses a preliminary inter-comparison of the results of both techniques, for a test site located in the metropolitan area of Barcelona (Spain), where interferometric Sentinel-1 data were analysed.

Gamma Transition Jump for PS2

CERN Document Server

Bartmann, W; Métral, E; Möhl, D; Peggs, S

2008-01-01

The PS2, which is proposed as a replacement for the existing ~50-year old PS accelerator, is presently considered to be a normal conducting synchrotron with an injection kinetic energy of 4 GeV and a maximum energy of 50 GeV. One of the possible lattices (FODO option) foresees crossing of transition energy near 10 GeV. Since the phase-slip-factor $\\eta$ becomes very small near transition energy, many intensity dependent effects can take place in both longitudinal and transverse planes. The aim of the present paper is on the one hand to scale the gamma transition jump, used since 1973 in the PS, to the projected PS2 and on the other hand based on these results the analysis of the implementation and feasibility of a gamma transition jump scheme in a conventional FODO lattice.

iPS-Cinderella Story in Cell Biology

Directory of Open Access Journals (Sweden)

Editorial

2010-01-01

Full Text Available As we step through the frontiers of modern Science, we are all witnesses to the Cinderella story repeating itself in the form of the iPS. The process of re-programming adult somatic cells to derive Induced Pluripotent stem cells (iPS with the wand of transcription factors and then differentiating them back to adult somatic cells resembles the transformation of Cinderella from a Cinder girl to princess and back to a Cinder girl after the ball; but the iPS-Cinderella is the most fascinating thing ever in cell biology!From the day iPS first made its headlines when it was first produced by Shinya Yamanaka at Kyoto University in Japan, Stem Cell scientists all over the world are re- doing their experiments so far done using other sources like embryonic and adult Stem cells with the iPS cells exploring their potential to the fullest. A Stem Cell science news page without this magic word of iPS is difficult to imagine these days and Scientists have been successful in growing most of the adult Cell types from iPS cells.iPS cells was the key to solve the problems of Immune rejection and Immunosupression required when using other allogeneic Stem cell types which had baffled scientists previously. But the issues raised by scientists about the use of viruses and Oncogenes in producing iPS cells were made groundless when scientists in February 2008 published the discovery of a technique that could remove oncogenes after the induction of pluripotency and now it is possible to induce pluripotency using plasmid transfection, piggyback transposon system and piggyback transposon system combined with a non viral vector system. The word of the day is pIPS which are protein-induced Pluripotent stem cells which are iPS cells that were generated without any genetic alteration of the adult cell. This research by the group of Sheng Ding in La Jolla, California made public in April 2009 showed that the generation of poly-arginine anchors was sufficient to induce

A Large-Acceptance Detector System for Electron Scattering from Polarized Internal targets.

NARCIS (Netherlands)

Passchier, E.; Bouwhuis, M.; Choi, S.; Zhou, Z.L.; Alarcon, R.; Anghinolfi, M.; Botto, T.; van den Brand, J.F.J.; Bulten, H.J.; Dimitroyannis, D.; Doets, M.; Ent, R.; Ferro Luzzi, M.M.E.; Higinbotham, D.W.; de Jager, C.W.; Lang, J.; de Lange, D.J.; Nikolenko, D.; Nooren, G.J.; Papadakis, N.; Passchier, I.; Popov, S.G.; Rachek, I.; Ripani, M.; Steijger, J.J.M.; Taiuti, M.; Vodinas, N.; de Vries, H.

1997-01-01

The design and the performance of a non-magnetic detector setup for internal target physics at the NIKHEF electron-scattering facility is described. The detector setup, used in the first internal-target experiment at the AmPS ring, measures the spin dependence in the elastic and break-up reaction

Persistent Scatterer Interferometry analysis of ground deformation in the Po Plain (Piacenza-Reggio Emilia sector, Northern Italy): seismo-tectonic implications

Science.gov (United States)

Antonielli, Benedetta; Monserrat, Oriol; Bonini, Marco; Cenni, Nicola; Devanthéry, Núria; Righini, Gaia; Sani, Federico

2016-08-01

This work aims to explore the ongoing tectonic activity of structures in the outermost sector of the Northern Apennines, which represents the active leading edge of the thrust belt and is dominated by compressive deformation. We have applied the Persistent Scatterer Interferometry (PSI) technique to obtain new insights into the present-day deformation pattern of the frontal area of the Northern Apennine. PSI has proved to be effective in detecting surface deformation of wide regions involved in low tectonic movements. We used 34 Envisat images in descending geometry over the period of time between 2004 and 2010, performing about 300 interferometric pairs. The analysis of the velocity maps and of the PSI time-series has allowed to observe ground deformation over the sector of the Po Plain between Piacenza and Reggio Emilia. The time-series of permanent GPS stations located in the study area, validated the results of the PSI technique, showing a good correlation with the PS time-series. The PS analysis reveals the occurrence of a well-known subsidence area on the rear of the Ferrara arc, mostly connected to the exploitation of water resources. In some instances, the PS velocity pattern reveals ground uplift (with mean velocities ranging from 1 to 2.8 mm yr-1) above active thrust-related anticlines of the Emilia and Ferrara folds, and part of the Pede-Apennine margin. We hypothesize a correlation between the observed uplift deformation pattern and the growth of the thrust-related anticlines. As the uplift pattern corresponds to known geological features, it can be used to constrain the seismo-tectonic setting, and a working hypothesis may involve that the active Emilia and Ferrara thrust folds would be characterized by interseismic periods possibly dominated by aseismic creep.

Understanding Laterally Varying Path Effects on P/S Ratios and their Effectiveness for Event Discrimination at Local Distances

Science.gov (United States)

Pyle, M. L.; Walter, W. R.

2017-12-01

Discrimination between underground explosions and naturally occurring earthquakes is an important endeavor for global security and test-ban treaty monitoring, and ratios of seismic P to S-wave amplitudes at regional distances have proven to be an effective discriminant. The use of the P/S ratio is rooted in the idea that explosive sources should theoretically only generate compressional energy. While, in practice, shear energy is observed from explosions, generally when corrections are made for magnitude and distance, P/S ratios from explosions are higher than those from surrounding earthquakes. At local distances (chemical explosions at the Nevada National Security Site (NNSS) designed to improve our understanding and modeling capabilities of shear waves generated by explosions. Phase I consisted of 5 explosions in granite and Phase II will move to a contrasting dry alluvium geology. We apply a high-resolution 2D attenuation model to events near the NNSS to examine what effect path plays in local P/S ratios, and how well an earthquake-derived model can account for shallower explosion paths. The model incorporates both intrinsic attenuation and scattering effects and extends to 16 Hz, allowing us to make lateral path corrections and consider high-frequency ratios. Preliminary work suggests that while 2D path corrections modestly improve earthquake amplitude predictions, explosion amplitudes are not well matched, and so P/S ratios do not necessarily improve. Further work is needed to better understand the uses and limitation of 2D path corrections for local P/S ratios.

Using PS-InSAR data in landslide hazard management: the case of Veneto Region (NE Italy)

Science.gov (United States)

Floris, Mario; Viganò, Alessandro; Busnardo, Enrico; Arziliero, Luciano; Zanette, Doriano

2013-04-01

The Project Persistent Scatterers Interferometry, performed by the Italian Ministry of Environment and Territory of the Sea (METS) in the framework of the Extraordinary Plan of Environmental Remote Sensing, has made available a high quantity of data useful for local Authorities (Regions, Provinces, and Municipalities) in the management of the main geological hazards, such as landslides, subsidence, and sinkholes. The main output of the Project consists of ground displacements and velocities measured at target points over the entire Italian territory by using PS-InSAR processing technique applied to SAR data acquired by satellites ESA (European Space Agency) ERS-1 and ERS-2 (Earth Resources Satellite) and ENVISAT (Environmental Satellite) in the period 1992-2010. Description and results of the Project are available for public browsing at the geoportal of the METS (http://www.pcn.minambiente.it). On the basis of PS-InSAR data, several studies have been recently performed for the identification and characterization of landslides both at small and large scale. These studies led to a more precise delimitation of instable areas and to a better evaluation of the state of activity of mass movements. But, as now well known, interferometry techniques can't be applied to the whole territory due to geometric distortions in SAR data acquisition and to ground conditions. In this work we analyze the potentiality of PS-InSAR data from the Project Persistent Scatterers Interferometry in landslide hazard management of the Veneto Region, located in the north-eastern part of Italy. A synthetic description on the main features of landslides affecting the Region is reported, then the percentage of instabilities where PS-InSAR data can be used, is calculated. At the scale of the entire Region we suggest to follow the method proposed in the scientific literature to evaluate the state of activity of landslides on the basis of the measured velocities at the ground surface, while at local

Picosecond transient backward stimulated Raman scattering and pumping of femtosecond dye lasers

Science.gov (United States)

Arrivo, Steven M.; Spears, Kenneth G.; Sipior, Jeffrey

1995-02-01

We report studies of transient, backward stimulated, Raman scattering (TBSRS) in solvents with a 10 Hz, 27 ps, 532 nm pump laser. The TBSRS effect was used to create pulses at 545 nm and 630 nm with durations of 2-3 ps and 5-10 μJ of energy. The duration, energy and fluctuations of the Raman pulse were studied as a function of pump energy and focal parameters. A 5 μJ Raman pulse was amplified in either a Raman amplifier or two stage dye amplifier to 1 mJ levels. A 545 nm pulse of 3 ps duration was generated in CCl 4 and was then used to pump a short cavity dye laser (SCDL). The SCDL oscillator and a 5 stage dye amplifier provided a pulse of 700 fs and 400 μJ that was tunable near 590 nm.

Direct Observation on Spin-Coating Process of PS- b -P2VP Thin Films

Energy Technology Data Exchange (ETDEWEB)

Ogawa, Hiroki; Takenaka, Mikihito; Miyazaki, Tsukasa; Fujiwara, Akihiko; Lee, Byeongdu; Shimokita, Keisuke; Nishibori, Eiji; Takata, Masaki

2016-05-10

We studied the structural development of symmetric poly(styrene-b-2-vinylpyridine) (PS-b-P2VP) block copolymers during spin-coating using in situ grazing incidence small angle X-ray scattering (GISAXS) measurements. During the spin-coating process, after the formation of the micelles in dilute solution, the selective solvent induced two kinds of the morphological transition. Firstly, the disordered spherical micelles were transformed into a BCC lattice of spheres of which the (110) plane was oriented perpendicularly to the substrate surface. Secondly, further evaporation induced a transition from spheres on the BCC lattice into cylindrical structures. The orientation of the cylinders perpendicular to the substrate surface was induced by solvent convection perpendicular to the substrate, which occurs during rapid solvent evaporation. After this transition, vitrification of PS and P2VP prevented any further transition from cylinders to the more thermodynamically stable lamellar structures, as are generally observed as the bulk equilibrium state.

Cross-channel coupling in positron-atom scattering

International Nuclear Information System (INIS)

McAlinden, M.T.; Kernoghan, A.A.; Walters, H.R.J.

1994-01-01

Coupled-state calculations including positronium channels are reported for positron scattering by atomic hydrogen, lithium and sodium. Integrated cross sections and total cross sections are presented for all three atoms. For lithium differential cross sections are also given. Throughout, comparison is made between results calculated with and without inclusion of the positronium channels. S-wave cross sections for positron scattering by atomic hydrogen in the Ps(1s, 2s, 2p) + H(1s, 2s, 2p) approximation show the high energy resonance first observed by Higgins and Burke in the coupled-static approximation. This resonance has now moved up to 51.05 eV and narrowed in width to 2.92 eV. Other pronounced structure is seen in the S-wave cross sections between 10 and 20 eV; it is tentatively suggested that this structure may be due to the formation of a temporary pseudo-molecular collision complex. Results calculated in the Ps(1s, 2s, anti 3 anti s, anti 4 anti s, 2p, anti 3 anti p, anti 4 anti p, anti 3 anti d, anti 4 anti d) + H(1s, 2s, anti 3 anti s, anti 4 anti s, 2p, anti 3 anti p, anti 4 anti p, anti 3 anti d, anti 4 anti d) approximation show convergence towards accurate values in the energy region below and in the Ore gap. Contrary to previous work on lithium using only an atomic basis, it is found that coupling to the 3d state of lithium is not so important when positronium channels are included; this is because a mixed basis of atom and positronium states gives a more rapidly convergent approximation than an expansion based on atom states alone. The threshold behaviour of the elastic cross section and the Ps(1s) formation cross section for lithium is investigated. Results in the Ps(1s, 2s, 2p) + Na(3s, 3p) approximation for sodium show good agreement with the total cross section measurements of Kwan et al. (orig.)

Material science and neutron scattering

International Nuclear Information System (INIS)

1983-01-01

Neutron scattering experiments complete and extend the condensed matter studies made with X and gamma rays. Then story show a permanent evolution of the instrumentation, methods and experimental techniques to improve the result quality. This is more especially important as neutron sources are weaker than photon and electron sources. Progress in this research domain is due, in most part, to discovery and development of materials for the different measurement device components [fr

Functional characterization of calcineurin homologs PsCNA1/PsCNB1 in Puccinia striiformis f. sp. tritici using a host-induced RNAi system.

Directory of Open Access Journals (Sweden)

Hong Zhang

Full Text Available Calcineurin plays a key role in morphogenesis, pathogenesis and drug resistance in most fungi. However, the function of calcineurin genes in Puccinia striiformis f. sp. tritici (Pst is unclear. We identified and characterized the calcineurin genes PsCNA1 and PsCNB1 in Pst. Phylogenetic analyses indicate that PsCNA1 and PsCNB1 form a calcium/calmodulin regulated protein phosphatase belonging to the calcineurin heterodimers composed of subunits A and B. Quantitative RT-PCR analyses revealed that both PsCNA1 and PsCNB1 expression reached their maximum in the stage of haustorium formation, which is one day after inoculation. Using barely stripe mosaic virus (BSMV as a transient expression vector in wheat, the expression of PsCNA1 and PsCNB1 in Pst was suppressed, leading to slower extension of fungal hyphae and reduced production of urediospores. The immune-suppressive drugs cyclosporin A and FK506 markedly reduced the germination rates of urediospores, and when germination did occur, more than two germtubes were produced. These results suggest that the calcineurin signaling pathway participates in stripe rust morphogenetic differentiation, especially the formation of haustoria during the early stage of infection and during the production of urediospores. Therefore PsCNA1 and PsCNB1 can be considered important pathogenicity genes involved in the wheat-Pst interaction.

100-ps framing-camera tube

International Nuclear Information System (INIS)

Kalibjian, R.

1978-01-01

The optoelectronic framing-camera tube described is capable of recording two-dimensional image frames with high spatial resolution in the <100-ps range. Framing is performed by streaking a two-dimensional electron image across narrow slits. The resulting dissected electron line images from the slits are restored into framed images by a restorer deflector operating synchronously with the dissector deflector. The number of framed images on the tube's viewing screen equals the number of dissecting slits in the tube. Performance has been demonstrated in a prototype tube by recording 135-ps-duration framed images of 2.5-mm patterns at the cathode. The limitation in the framing speed is in the external drivers for the deflectors and not in the tube design characteristics. Faster frame speeds in the <100-ps range can be obtained by use of faster deflection drivers

PsHint1, associated with the G-protein α subunit PsGPA1, is required for the chemotaxis and pathogenicity of Phytophthora sojae.

Science.gov (United States)

Zhang, Xin; Zhai, Chunhua; Hua, Chenlei; Qiu, Min; Hao, Yujuan; Nie, Pingping; Ye, Wenwu; Wang, Yuanchao

2016-02-01

Zoospore chemotaxis to soybean isoflavones is essential in the early stages of infection by the oomycete pathogen Phytophthora sojae. Previously, we have identified a G-protein α subunit encoded by PsGPA1 which regulates the chemotaxis and pathogenicity of P. sojae. In the present study, we used affinity purification to identify PsGPA1-interacting proteins, including PsHint1, a histidine triad (HIT) domain-containing protein orthologous to human HIT nucleotide-binding protein 1 (HINT1). PsHint1 interacted with both the guanosine triphosphate (GTP)- and guanosine diphosphate (GDP)-bound forms of PsGPA1. An analysis of the gene-silenced transformants revealed that PsHint1 was involved in the chemotropic response of zoospores to the isoflavone daidzein. During interaction with a susceptible soybean cultivar, PsHint1-silenced transformants displayed significantly reduced infectious hyphal extension and caused a strong cell death in plants. In addition, the transformants displayed defective cyst germination, forming abnormal germ tubes that were highly branched and exhibited apical swelling. These results suggest that PsHint1 not only regulates chemotaxis by interacting with PsGPA1, but also participates in a Gα-independent pathway involved in the pathogenicity of P. sojae. © 2015 BSPP AND JOHN WILEY & SONS LTD.

LS1 Report: PS beams are back!

CERN Multimedia

Katarina Anthony & Anaïs Schaeffer

2014-01-01

For the first time in over 15 months, there are beams back in the PS. Making their first tour of the accelerator today, 20 June, their injection marks the end of weeks of cold checkouts and hardware commissioning in the PS.   The CERN Control Centre (CCC) is back in business: people gather to restart the LHC injectors, today the PS. Since hardware commissioning was wrapped up on 23 May, the Operations Group (BE-OP) has been conducting cold checkouts on the PS. This involves switching on all of the machine's systems, verifying that they respond to commands by OP and ensuring they are calibrated to beam timings. "These verifications were done, in part, during the hardware commissioning dry runs," says Rende Steerenberg, PS section leader. "But the cold checkouts are on a much larger scale, as we act as if there is beam in the whole machine. We placed a full load on the controls system, cooling, networks, etc. in order to setup the accelerator in the most realis...

Enhanced personal protection at the PS

CERN Multimedia

Samuel Morier Genoud

2013-01-01

Pictures 03, 06, 07 08 : Pierre Ninin, deputy group leader of GS-ASE and responsible for the installation of the new PS complex safety system, in front of a new access control system.Pictures 10, 12 ,13 : View of Building 271, the future control centre of the new PS complex safety system.

The PS will soon be back in operation

CERN Multimedia

2006-01-01

The PS's power supply system is undergoing repairs for the accelerator to restart on 26 June. The AB Department's Power Converter Group is working flat out with Siemens to return the PS's power supply system to working order. A problem appeared on the insulation of the power cables of the rotor of the rotating machine (photo) which supplies power to the PS magnets. To prevent more significant damage to the rotating machine, the AB Department, with the approval of the CERN Management, decided to shut down the PS which had started running on 15 May. Everything is being done to restart the accelerator on 26 June. The PS's rotating machine comprises a motor coupled to a generator. The generator's rotor acts like a flywheel, supplying high-power pulses of 40 to 50 megawatts to the PS magnets. The 6 megawatt motor drives the installation at 1000 revolutions per minute and compensates only for variations in speed. It is an essential interface since it would be hard to imagine connecting such an electrical charge, p...

Core-shell-corona micelles by PS-b-P2VP-b-PEO copolymers: focus on the water-induced micellization process.

Science.gov (United States)

Willet, Nicolas; Gohy, Jean-François; Auvray, Loïc; Varshney, Sunil; Jérôme, Robert; Leyh, Bernard

2008-04-01

It is now well established that amphiphilic PS-b-P2VP-b-PEO linear triblock copolymers can form multilayered assemblies, thus core-shell-corona (CSC) micelles, in water. Micellization is triggered by addition of a small amount of water into a dilute solution of the PS-b-P2VP-b-PEO copolymer in a non-selective organic solvent. However, the phenomena that take place at the very beginning of this process are poorly documented. How these copolymer chains are perturbed by addition of water was investigated in this work by light and neutron scattering techniques and transmission electron microscopy. It was accordingly possible to determine the critical water concentration (CWC), the compactness of the nano-objects in solution, their number of aggregation, and their hydrodynamic diameter at each step of the micellization process.

Sheared Layers in the Continental Crust: Nonlinear and Linearized inversion for Ps receiver functions

Science.gov (United States)

Park, J. J.

2017-12-01

Sheared Layers in the Continental Crust: Nonlinear and Linearized inversion for Ps receiver functions Jeffrey Park, Yale University The interpretation of seismic receiver functions (RFs) in terms of isotropic and anisotropic layered structure can be complex. The relationship between structure and body-wave scattering is nonlinear. The anisotropy can involve more parameters than the observations can readily constrain. Finally, reflectivity-predicted layer reverberations are often not prominent in data, so that nonlinear waveform inversion can search in vain to match ghost signals. Multiple-taper correlation (MTC) receiver functions have uncertainties in the frequency domain that follow Gaussian statistics [Park and Levin, 2016a], so grid-searches for the best-fitting collections of interfaces can be performed rapidly to minimize weighted misfit variance. Tests for layer-reverberations can be performed in the frequency domain without reflectivity calculations, allowing flexible modelling of weak, but nonzero, reverberations. Park and Levin [2016b] linearized the hybridization of P and S body waves in an anisotropic layer to predict first-order Ps conversion amplitudes at crust and mantle interfaces. In an anisotropic layer, the P wave acquires small SV and SH components. To ensure continuity of displacement and traction at the top and bottom boundaries of the layer, shear waves are generated. Assuming hexagonal symmetry with an arbitrary symmetry axis, theory confirms the empirical stacking trick of phase-shifting transverse RFs by 90 degrees in back-azimuth [Shiomi and Park, 2008; Schulte-Pelkum and Mahan, 2014] to enhance 2-lobed and 4-lobed harmonic variation. Ps scattering is generated by sharp interfaces, so that RFs resemble the first derivative of the model. MTC RFs in the frequency domain can be manipulated to obtain a first-order reconstruction of the layered anisotropy, under the above modeling constraints and neglecting reverberations. Examples from long

Investigating Spatial Patterns of Persistent Scatterer Interferometry Point Targets and Landslide Occurrences in the Arno River Basin

Directory of Open Access Journals (Sweden)

Ping Lu

2014-07-01

Full Text Available Persistent Scatterer Interferometry (PSI has been widely used for landslide studies in recent years. This paper investigated the spatial patterns of PSI point targets and landslide occurrences in the Arno River basin in Central Italy. The main purpose is to analyze whether spatial patterns of Persistent Scatterers (PS can be recognized as indicators of landslide occurrences throughout the whole basin. The bivariate K-function was employed to assess spatial relationships between PS and landslides. The PSI point targets were acquired from almost 4 years (from March 2003 to January 2007 of RADARSAT-1 images. The landslide inventory was collected from 15 years (from 1992–2007 of surveying and mapping data, mainly including remote sensing data, topographic maps and field investigations. The proposed approach is able to assess spatial patterns between a variety of PS and landslides, in particular, to understand if PSI point targets are spatially clustered (spatial attraction or randomly distributed (spatial independency on various types of landslides across the basin. Additionally, the degree and scale distances of PS clustering on a variety of landslides can be characterized. The results rejected the null hypothesis that PSI point targets appear to cluster similarly on four types of landslides (slides, flows, falls and creeps in the Arno River basin. Significant influence of PS velocities and acquisition orbits can be noticed on detecting landslides with different states of activities. Despite that the assessment may be influenced by the quality of landslide inventory and Synthetic Aperture Radar (SAR images, the proposed approach is expected to provide guidelines for studies trying to detect and investigate landslide occurrences at a regional scale through spatial statistical analysis of PS, for which an advanced understanding of the impact of scale distances on landslide clustering is fundamentally needed.

Back to work for the PS

CERN Multimedia

2006-01-01

On 22 June, the PS's rotating machine started turning again for the first time since its enforced shutdown one month ago (see Bulletin No. 23-24/2006) - and the PS was back in operation the very next day! A team from Siemens worked their socks off, 6 days a week for one month (including public holidays), to repair the electrical power supply in collaboration with the AB/PO Group's Main Power Converters (MPC) Section. The generator's faulty rotor was dismantled and replaced by the renovated spare rotor. The multitude of electrical and mechanical connections together with the sheer weight of the rotor (80 tonnes) made this an extremely complex job. The AB/PO Group used the shutdown to test a back-up solution for the PS power supply. The accelerator was directly wired up to the 18 kV electrical network via a 13 MVA transformer, installed at the end of the 1970s but never used. This solution succeeded in bringing the PS back into operation but at limited energy and frequency. Just 14 GeV could be achieved, whic...

Synthesis and Characterization of the Rubidium Thiophosphate Rb 6 (PS 5 )(P 2 S 10 ) and the Rubidium Silver Thiophosphates Rb 2 AgPS 4 , RbAg 5 (PS 4 ) 2 and Rb 3 Ag 9 (PS 4 ) 4

KAUST Repository

Alahmary, Fatimah S.

2016-02-18

The metal thiophosphates Rb2AgPS4 (2), RbAg5(PS4)2 (3), and Rb3Ag9(PS4)4 (4) were synthesized by stoichiometric reactions, whereas Rb6(PS5)(P2S10) (1) was prepared with excess amount of sulfur. The compounds crystallize as follows: 1 monoclinic, P21/c (no. 14), a = 17.0123(7) Å, b = 6.9102(2) Å, c = 23.179(1) Å, β = 94.399(4)°; 2 triclinic, P ¯ (no. 2), a = 6.600(1) Å, b = 6.856(1) Å, c = 10.943(3) Å, α = 95.150(2)°, β = 107.338(2)°, γ = 111.383(2)°; 3 orthorhombic, Pbca (no. 61), a = 12.607(1) Å, b = 12.612(1) Å, c = 17.759(2) Å; 4 orthorhombic, Pbcm (no. 57), a = 6.3481(2) Å, b = 12.5782(4) Å, c = 35.975(1) Å. The crystal structures contain discrete units, chains, and 3D polyanionic frameworks composed of PS4 tetrahedral units arranged and connected in different manner. Compounds 1-3 melt congruently, whereas incongruent melting behavior was observed for compound 4. 1-4 are semiconductors with bandgaps between 2.3 and 2.6 eV and thermally stable up to 450 °C in an inert atmosphere. Copyright © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

High-precision calculation of loosely bound states of LiPs+ and NaPs+

International Nuclear Information System (INIS)

Yamashita, Takuma; Kino, Yasushi

2015-01-01

A positronic alkali atom would be the first step to investigate behavior of a positronium(Ps) in an external field from atoms/molecules because the system can be regarded as a simple three-body system using model potentials reflecting electron orbitals of the ion core. In order to precisely determine binding energies and structures of positronic alkali atoms (LiPs + and NaPs + ), we improve the model potential so as to reproduce highly excited atomic energy levels of alkali atoms (Li and Na). The polarization potential included by the model potential is expanded in terms of Gaussian functions to finely determine a short range part of the potential which has been assumed to be a simple form. We find better reproducibility not only of atomic levels of the alkali atoms but also of the dipole polarizability of the core ion than previous works. We construct a model potential between a positron and an ion core based on the model potential between the valence electron and ion core. Binding energies associated with a dissociation of the alkali ion core and positronium, and interparticle distances are recalculated. Our results show slightly deeper bound than other previous studies. (paper)

Phosphorene-directed self-assembly of asymmetric PS-b-PMMA block copolymer for perpendicularly-oriented sub-10 nm PS nanopore arrays

Science.gov (United States)

Zhang, Ziming; Zheng, Lu; Khurram, Muhammad; Yan, Qingfeng

2017-10-01

Few-layer black phosphorus, also known as phosphorene, is a new two-dimensional material which is of enormous interest for applications, mainly in electronics and optoelectronics. Herein, we for the first time employ phosphorene for directing the self-assembly of asymmetric polystyrene-block-polymethylmethacrylate (PS-b-PMMA) block copolymer (BCP) thin film to form the perpendicular orientation of sub-10 nm PS nanopore arrays in a hexagonal fashion normal to the interface. We experimentally demonstrate that none of the PS and PMMA blocks exhibit preferential affinity to the phosphorene-modified surface. Furthermore, the perpendicularly-oriented PS nanostructures almost stay unchanged with the variation of number of layers of few-layer phosphorene nanoflakes between 15-30 layers. Differing from the neutral polymer brushes which are widely used for chemical modification of the silicon substrate, phosphorene provides a novel physical way to control the interfacial interactions between the asymmetric PS-b-PMMA BCP thin film and the silicon substrate. Based on our results, it is possible to build a new scheme for producing sub-10 nm PS nanopore arrays oriented perpendicularly to the few-layer phosphorene nanoflakes. Furthermore, the nanostructural microdomains could serve as a promising nanolithography template for surface patterning of phosphorene nanoflakes.

Phosphorene-directed self-assembly of asymmetric PS-b-PMMA block copolymer for perpendicularly-oriented sub-10 nm PS nanopore arrays.

Science.gov (United States)

Zhang, Ziming; Zheng, Lu; Khurram, Muhammad; Yan, Qingfeng

2017-10-20

Few-layer black phosphorus, also known as phosphorene, is a new two-dimensional material which is of enormous interest for applications, mainly in electronics and optoelectronics. Herein, we for the first time employ phosphorene for directing the self-assembly of asymmetric polystyrene-block-polymethylmethacrylate (PS-b-PMMA) block copolymer (BCP) thin film to form the perpendicular orientation of sub-10 nm PS nanopore arrays in a hexagonal fashion normal to the interface. We experimentally demonstrate that none of the PS and PMMA blocks exhibit preferential affinity to the phosphorene-modified surface. Furthermore, the perpendicularly-oriented PS nanostructures almost stay unchanged with the variation of number of layers of few-layer phosphorene nanoflakes between 15-30 layers. Differing from the neutral polymer brushes which are widely used for chemical modification of the silicon substrate, phosphorene provides a novel physical way to control the interfacial interactions between the asymmetric PS-b-PMMA BCP thin film and the silicon substrate. Based on our results, it is possible to build a new scheme for producing sub-10 nm PS nanopore arrays oriented perpendicularly to the few-layer phosphorene nanoflakes. Furthermore, the nanostructural microdomains could serve as a promising nanolithography template for surface patterning of phosphorene nanoflakes.

Fault Creep along the Southern San Andreas from Interferometric Synthetic Aperture Radar, Permanent Scatterers, and Stacking

Science.gov (United States)

Lyons, Suzanne; Sandwell, David

2003-01-01

Interferometric synthetic aperture radar (InSAR) provides a practical means of mapping creep along major strike-slip faults. The small amplitude of the creep signal (less than 10 mm/yr), combined with its short wavelength, makes it difficult to extract from long time span interferograms, especially in agricultural or heavily vegetated areas. We utilize two approaches to extract the fault creep signal from 37 ERS SAR images along the southem San Andreas Fault. First, amplitude stacking is utilized to identify permanent scatterers, which are then used to weight the interferogram prior to spatial filtering. This weighting improves correlation and also provides a mask for poorly correlated areas. Second, the unwrapped phase is stacked to reduce tropospheric and other short-wavelength noise. This combined processing enables us to recover the near-field (approximately 200 m) slip signal across the fault due to shallow creep. Displacement maps fiom 60 interferograms reveal a diffuse secular strain buildup, punctuated by localized interseismic creep of 4-6 mm/yr line of sight (LOS, 12-18 mm/yr horizontal). With the exception of Durmid Hill, this entire segment of the southern San Andreas experienced right-lateral triggered slip of up to 10 cm during the 3.5-year period spanning the 1992 Landers earthquake. The deformation change following the 1999 Hector Mine earthquake was much smaller (4 cm) and broader than for the Landers event. Profiles across the fault during the interseismic phase show peak-to-trough amplitude ranging from 15 to 25 mm/yr (horizontal component) and the minimum misfit models show a range of creeping/locking depth values that fit the data.

Further Examination of a Simplified Model for Positronium-Helium Scattering

Science.gov (United States)

DiRienzi, J.; Drachman, Richard J.

2012-01-01

While carrying out investigations on Ps-He scattering we realized that it would be possible to improve the results of a previous work on zero-energy scattering of ortho-positronium by helium atoms. The previous work used a model to account for exchange and also attempted to include the effect of short-range Coulomb interactions in the close-coupling approximation. The 3 terms that were then included did not produce a well-converged result but served to give some justification to the model. Now we improve the calculation by using a simple variational wave function, and derive a much better value of the scattering length. The new result is compared with other computed values, and when an approximate correction due to the van der Waals potential is included the total is consistent with an earlier conjecture.

Comparative, validity and responsiveness of the HOOS-PS and KOOS-PS to the WOMAC physical function subscale in total joint replacement for osteoarthritis

DEFF Research Database (Denmark)

Davis, A M; Perruccio, A V; Canizares, M

2009-01-01

OBJECTIVE: To evaluate the internal consistency of the Hip disability and Osteoarthritis Outcome Score-Physical Function Short-form (HOOS-PS) and the Knee injury and Osteoarthritis Outcome Score-Physical Function Short-form (KOOS-PS) in total hip replacement (THR) and total knee (TKR) replacement....... Construct validity and responsiveness were compared to the Western Ontario McMaster Universities' Osteoarthritis Index (WOMAC) Likert 3.0 physical function (PF) subscale and the PF excluding the items in the short measures (PF-exclusions). METHODS: Participants completed the full HOOS or KOOS, measures...... of fatigue, anxiety, depression and the Chronic Pain Grade (CPG) pre-surgery and the HOOS or KOOS 6 months post-surgery. Internal consistency for the HOOS-PS and KOOS-PS was calculated using Cronbach's alpha. For construct validity, it was hypothesized that correlations between the HOOS-PS or KOOS-PS and PF...

The LLL compact 10-ps streak camera

International Nuclear Information System (INIS)

Thomas, S.W.; Houghton, J.W.; Tripp, G.R.; Coleman, L.W.

1975-01-01

The 10-ps streak camera has been redesigned to simplify its operation, reduce manufacturing costs, and improve its appearance. The electronics have been simplified, a film indexer added, and a contacted slit has been evaluated. Data support a 10-ps resolution. (author)

PS, SL and LHC Auditoria change names

CERN Multimedia

2003-01-01

Following the replacement of the PS, SL and LHC Divisions by the AB and AT Divisions, the Auditoria are also changing their names. PS Auditorium is renamed AB Meyrin SL Auditorium is renamed AB Prévessin LHC Auditorium is renamed AT

Human hair follicle pluripotent stem (hfPS) cells promote regeneration of peripheral-nerve injury: an advantageous alternative to ES and iPS cells.

Science.gov (United States)

Amoh, Yasuyuki; Kanoh, Maho; Niiyama, Shiro; Hamada, Yuko; Kawahara, Katsumasa; Sato, Yuichi; Hoffman, Robert M; Katsuoka, Kensei

2009-08-01

The optimal source of stem cells for regenerative medicine is a major question. Embryonic stem (ES) cells have shown promise for pluripotency but have ethical issues and potential to form teratomas. Pluripotent stem cells have been produced from skin cells by either viral-, plasmid- or transposon-mediated gene transfer. These stem cells have been termed induced pluripotent stem cells or iPS cells. iPS cells may also have malignant potential and are inefficiently produced. Embryonic stem cells may not be suited for individualized therapy, since they can undergo immunologic rejection. To address these fundamental problems, our group is developing hair follicle pluripotent stem (hfPS) cells. Our previous studies have shown that mouse hfPS cells can differentiate to neurons, glial cells in vitro, and other cell types, and can promote nerve and spinal cord regeneration in vivo. hfPS cells are located above the hair follicle bulge in what we have termed the hfPS cell area (hfPSA) and are nestin positive and keratin 15 (K-15) negative. Human hfPS cells can also differentiate into neurons, glia, keratinocytes, smooth muscle cells, and melanocytes in vitro. In the present study, human hfPS cells were transplanted in the severed sciatic nerve of the mouse where they differentiated into glial fibrillary-acidic-protein (GFAP)-positive Schwann cells and promoted the recovery of pre-existing axons, leading to nerve generation. The regenerated nerve recovered function and, upon electrical stimulation, contracted the gastrocnemius muscle. The hfPS cells can be readily isolated from the human scalp, thereby providing an accessible, autologous and safe source of stem cells for regenerative medicine that have important advantages over ES or iPS cells. (c) 2009 Wiley-Liss, Inc.

Psühhodraama - spontaansuse kool / Taimi Elenurm

Index Scriptorium Estoniae

Elenurm, Taimi

2010-01-01

Viinis ja New Yorgis tegutsenud psühhiaatri Jakob Levy Moreno loodud psühhodraamast, mis võimaldab rollimängu kaudu näha ennast läbi teiste silmade, aga ka vabaneda pingetest andes võimaluse käituda teisiti kui tavaelus

Improved performances of 36 m small-angle neutron scattering spectrometer BATAN in Serpong Indonesia

International Nuclear Information System (INIS)

Putra, Edy Giri Rachman; Bharoto; Santoso, Eddy; Ikram, Abarrul

2009-01-01

SMARTer, a 36 m small-angle neutron scattering (SANS) spectrometer owned by the National Nuclear Energy Agency of Indonesia (BATAN) was installed at the Neutron Scattering Laboratory (NSL) in Serpong, Indonesia. Lots of works on replacing, upgrading and improving the control system, experimental methods, data collection and reduction in the last two years have been carried out to optimize the performance of SMARTer. Some standard samples such as silver behenate, monodisperse polystyrene nanoparticle, porous silica and block copolymer PS-PEP film were measured for the inter-laboratory comparison.

Ps 22 in Gospels’ interpretation of Passion

Directory of Open Access Journals (Sweden)

Sylwester Jędrzejewski

2012-09-01

Full Text Available Ps 22 is a piece of artistically high poetry, clear images and metaphors, historical and prophetic references. The conviction of biblical scholars that the New Testament writers has recognized in Ps 22 prophetic witness of passion, accompanies the Church from its beginnings. The words of Jesus on the cross, taken from Ps 22: 2, have a character of lamentable re-symbolization of the prayer of Israel. These words establish a theological answer in the form of suitable credo as well. Dramatic question “why?” is connected with a proclamation and identification “My God”. The personal experience of oppression and death is included by Jesus in the history of his nation and in the experience of God. Ps 22 in the Gospels’ passion context becomes a proclamation form of prayer and a very personal, expressed in such dramatic circumstances confession of the faith.

Scattering amplitudes in open superstring theory

Energy Technology Data Exchange (ETDEWEB)

Schlotterer, Oliver

2011-07-15

The present thesis deals with the theme field of the scattering amplitudes in theories of open superstrings. Especially two different formalisms for the handling of superstrings are introduced and applied for the calaculation of tree-level amplitudes - the Ramond- Neveu-Schwarz (RNS) and the Pure-Spinor (PS) formalism. The RNS approach is proved as flexible in order to describe compactification of the initially ten flat space-time dimensions to four dimensions. We solve the technical problems, which result from the interacting basing world-sheet theory with conformal symmetry. This is used to calculate phenomenologically relevant scattering amplitudes of gluons and quarks as well as production rates of massive harmonic vibrations, which were already identified as virtual exchange particles on the massless level. In the case of a low string mass scale in the range of some Tev the string-specific signatures in parton collisions can be observed in the near future in the LHC experiment at CERN and indicated as first experimental proof of the string theory. THose string effects occur universally for a wide class of string ground states respectively internal geometries and represent an elegant way to avoid the so-called landscape problem of the string theory. A further theme complex in this thesis is based on the PS formalism, which allows a manifestly supersymmetric treatment of scattering amplitudes in ten space-time dimension with sixteen supercharges. We introduce a family of superfields, which occur in massless amplitudes of the open string and can be naturally identified with diagrams of three-valued knots. Thereby we reach not only a compact superspace representation of the n-point field-theory amplitude but can also write the complete superstring n-point amplitude as minimal linear combination of partial amplitudes of the field theory as well as hypergeometric functions. The latter carry the string effects and are analyzed from different perspectives, above all

Scattering amplitudes in open superstring theory

International Nuclear Information System (INIS)

Schlotterer, Oliver

2011-01-01

The present thesis deals with the theme field of the scattering amplitudes in theories of open superstrings. Especially two different formalisms for the handling of superstrings are introduced and applied for the calaculation of tree-level amplitudes - the Ramond- Neveu-Schwarz (RNS) and the Pure-Spinor (PS) formalism. The RNS approach is proved as flexible in order to describe compactification of the initially ten flat space-time dimensions to four dimensions. We solve the technical problems, which result from the interacting basing world-sheet theory with conformal symmetry. This is used to calculate phenomenologically relevant scattering amplitudes of gluons and quarks as well as production rates of massive harmonic vibrations, which were already identified as virtual exchange particles on the massless level. In the case of a low string mass scale in the range of some Tev the string-specific signatures in parton collisions can be observed in the near future in the LHC experiment at CERN and indicated as first experimental proof of the string theory. THose string effects occur universally for a wide class of string ground states respectively internal geometries and represent an elegant way to avoid the so-called landscape problem of the string theory. A further theme complex in this thesis is based on the PS formalism, which allows a manifestly supersymmetric treatment of scattering amplitudes in ten space-time dimension with sixteen supercharges. We introduce a family of superfields, which occur in massless amplitudes of the open string and can be naturally identified with diagrams of three-valued knots. Thereby we reach not only a compact superspace representation of the n-point field-theory amplitude but can also write the complete superstring n-point amplitude as minimal linear combination of partial amplitudes of the field theory as well as hypergeometric functions. The latter carry the string effects and are analyzed from different perspectives, above all

Real-life experience of using conventional disease-modifying anti-rheumatic drugs (DMARDs) in psoriatic arthritis (PsA). Retrospective analysis of the efficacy of methotrexate, sulfasalazine, and leflunomide in PsA in comparison to spondyloarthritides other than PsA and literature review of the use of conventional DMARDs in PsA

Science.gov (United States)

Roussou, Euthalia; Bouraoui, Aicha

2017-01-01

Objective With the aim of assessing the response to treatment with conventional disease-modifying anti-rheumatic drugs (DMARDs) used in patients with psoriatic arthritis (PsA), data on methotrexate, sulfasalazine (SSZ), and leflunomide were analyzed from baseline and subsequent follow-up (FU) questionnaires completed by patients with either PsA or other spondyloarthritides (SpAs). Material and Methods A single-center real-life retrospective analysis was performed by obtaining clinical data via questionnaires administered before and after treatment. The indices used were erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Function Index (BASFI), wellbeing (WB), and treatment effect (TxE). The indices measured at baseline were compared with those measured on one occasion in a FU visit at least 1 year later. Results A total of 73 patients, 51 with PsA (mean age 49.8±12.8 years; male-to-female ratio [M:F]=18:33) and 22 with other SpAs (mean age 50.6±16 years; M:F=2:20), were studied. BASDAI, BASFI, and WB displayed consistent improvements during FU assessments in both PsA patients and controls in comparison to baseline values. SSZ exhibited better efficacy as confirmed by TxE in both PsA patients and controls. ESR and CRP displayed no differences in either the PsA or the SpA group between the cases before and after treatment. Conclusion Real-life retrospective analysis of three DMARDs used in PsA (and SpAs other than PsA) demonstrated that all three DMARDs that were used brought about improvements in BASDAI, BASFI, TxE, and WB. However, the greatest improvements at FU were seen with SSZ use in both PsA and control cohorts. PMID:28293446

Bond Shortening (1.4 Å) in the Singlet and Triplet Excited States of [Ir2(dimen)4]2+ in Solution Determined by Time-Resolved X-ray Scattering

DEFF Research Database (Denmark)

Haldrup, Martin Kristoffer; Harlang, Tobias; Christensen, Morten

2011-01-01

Ground- and excited-state structures of the bimetallic, ligand-bridged compound Ir2(dimen)42+ are investigated in acetonitrile by means of time-resolved X-ray scattering. Following excitation by 2 ps laser pulses at 390 nm, analysis of difference scattering patterns obtained at eight different ti...

Electron back scattered diffraction study of SmCo magnets

International Nuclear Information System (INIS)

Yonamine, T.; Fukuhara, M.; Machado, R.; Missell, F.P.

2008-01-01

The remanence and energy product of permanent magnets is a strong function of their crystallographic texture. Electron back scattered diffraction (EBSD) is a tool for texture analysis providing information about the atomic layers up to 50 nm below the surface of the material. This paper discusses experimental requirements for performing EBSD measurements on rare-earth permanent magnets and presents results on commercial SmCo magnet material. EBSD measurements proved to be very sensitive to misaligned grains and were sensitive to texture in good agreement with information provided by X-ray diffraction scans. Results for nanostructured Sm(CoFeCuZr) z magnets are also discussed

Updating the Psoriatic Arthritis (PsA) Core Domain Set

DEFF Research Database (Denmark)

Orbai, Ana-Maria; de Wit, Maarten; Mease, Philip J

2017-01-01

OBJECTIVE: To include the patient perspective in accordance with the Outcome Measures in Rheumatology (OMERACT) Filter 2.0 in the updated Psoriatic Arthritis (PsA) Core Domain Set for randomized controlled trials (RCT) and longitudinal observational studies (LOS). METHODS: At OMERACT 2016, research...... conducted to update the PsA Core Domain Set was presented and discussed in breakout groups. The updated PsA Core Domain Set was voted on and endorsed by OMERACT participants. RESULTS: We conducted a systematic literature review of domains measured in PsA RCT and LOS, and identified 24 domains. We conducted...... and breakout groups at OMERACT 2016 in which findings were presented and discussed. The updated PsA Core Domain Set endorsed with 90% agreement by OMERACT 2016 participants included musculoskeletal disease activity, skin disease activity, fatigue, pain, patient's global assessment, physical function, health...

NaPdPS{sub 4} and RbPdPS{sub 4}: systems with infinite straight ((1)/({infinity}))[PdPS{sub 4}]{sup -} chains soluble in polar solvents and the structure of cubic RbPdPS{sub 4}{l_brace}Rb{sub 0.33}P{sub 0.4}S{sub 2.23}O{sub x}{r_brace}

Energy Technology Data Exchange (ETDEWEB)

Coste, Servane; Hanko, Jason; Bujoli-Doeuff, Martine; Louarn, Guy; Evain, Michel; Brec, Raymond; Alonso, Bruno; Jobic, S; Kanatzidis, Mercouri G

2003-11-01

The synthesis, crystal structures, chemical and spectroscopic properties of NaPdPS{sub 4}, RbPdPS{sub 4}, and RbPdPS{sub 4}{l_brace}Rb{sub 0.33}P{sub 0.4}S{sub 2.23}O{sub x}{r_brace} are described. NaPdPS{sub 4}, RbPdPS{sub 4}, are isostructural and crystallize in the tetragonal system I4/mcm with cell parameters a=7.3074(8) A, c=12.2308(14) A and a=8.2954(3) A, c=12.2284(4) A respectively. RbPdPS{sub 4}{l_brace}Rb{sub 0.33}P{sub 0.4}S{sub 2.23}O{sub x}{r_brace} is cubic, space group Pm-3n and a=12.0042(2) A. All compounds contain the same ((1)/({infinity}))[PdPS{sub 4}]{sup -} chains made of alternating square planar Pd{sup 2+} cations and tetrahedral [PS{sub 4}]{sup 3-} anions. RbPdPS{sub 4}{l_brace}Rb{sub 0.33}P{sub 0.4}S{sub 2.23}O{sub x}{r_brace} contains co-crystallized highly disordered molecular species encapsulated within [Rb{sub 8}] cubic cavities. Spectroscopic solid state {sup 31}P NMR, infrared and Raman data as well as elemental analysis suggest that these species could be S{sub n}{sup 2-} (n=3 or 4) anions and possibly cationic [P{sub 4}S{sub 6}O]{sup 6+} fragments. NaPdPS{sub 4} and RbPdPS{sub 4} exhibit exfoliative dissolution in polar solvents giving rise to solutions that show signs of complex fluid behavior.

Mapping momentum-dependent electron-phonon coupling and nonequilibrium phonon dynamics with ultrafast electron diffuse scattering

Science.gov (United States)

Stern, Mark J.; René de Cotret, Laurent P.; Otto, Martin R.; Chatelain, Robert P.; Boisvert, Jean-Philippe; Sutton, Mark; Siwick, Bradley J.

2018-04-01

Despite their fundamental role in determining material properties, detailed momentum-dependent information on the strength of electron-phonon and phonon-phonon coupling (EPC and PPC, respectively) across the entire Brillouin zone has remained elusive. Here we demonstrate that ultrafast electron diffuse scattering (UEDS) directly provides such information. By exploiting symmetry-based selection rules and time resolution, scattering from different phonon branches can be distinguished even without energy resolution. Using graphite as a model system, we show that UEDS patterns map the relative EPC and PPC strength through their profound sensitivity to photoinduced changes in phonon populations. We measure strong EPC to the K -point TO phonon of A1' symmetry (K -A1' ) and along the entire TO branch between Γ -K , not only to the Γ -E2 g phonon. We also determine that the subsequent phonon relaxation of these strongly coupled optical phonons involve three stages: decay via several identifiable channels to TA and LA phonons (1 -2 ps), intraband thermalization of the non-equilibrium TA/LA phonon populations (30 -40 ps) and interband relaxation of the TA/LA modes (115 ps). Combining UEDS with ultrafast angle-resolved photoelectron spectroscopy will yield a complete picture of the dynamics within and between electron and phonon subsystems, helping to unravel complex phases in which the intertwined nature of these systems has a strong influence on emergent properties.

Improvement of Lambert-Beer law dynamic range by the use of temporal gates on transmitted light pulse through a scattering medium

International Nuclear Information System (INIS)

Yoshino, Hironori; Wada, Kenji; Horinaka, Hiromichi; Cho, Yoshio; Umeda, Tokuo; Osawa, Masahiko.

1995-01-01

The Lambert-Beer law holding for pulsed lights transmitted through a scattering medium was examined using a streak camera. The Lambert-Beer law dynamic range is found to be limited by floor levels that are caused by scattered photons and are controllable by the use of a temporal gate on the transmitted pulse. The dynamic range improvement obtained for a scattering medium of 2.8 cm -1 scattering coefficient of a thickness of 80 mm by a temporal gate of 60 ps was as much as 50 dB and the Lambert-Beer law dynamic rang reached to 140 dB. (author)

An HDAC2-TET1 switch at distinct chromatin regions significantly promotes the maturation of pre-iPS to iPS cells

Science.gov (United States)

Wei, Tingyi; Chen, Wen; Wang, Xiukun; Zhang, Man; Chen, Jiayu; Zhu, Songcheng; Chen, Long; Yang, Dandan; Wang, Guiying; Jia, Wenwen; Yu, Yangyang; Duan, Tao; Wu, Minjuan; Liu, Houqi; Gao, Shaorong; Kang, Jiuhong

2015-01-01

The maturation of induced pluripotent stem cells (iPS) is one of the limiting steps of somatic cell reprogramming, but the underlying mechanism is largely unknown. Here, we reported that knockdown of histone deacetylase 2 (HDAC2) specifically promoted the maturation of iPS cells. Further studies showed that HDAC2 knockdown significantly increased histone acetylation, facilitated TET1 binding and DNA demethylation at the promoters of iPS cell maturation-related genes during the transition of pre-iPS cells to a fully reprogrammed state. We also found that HDAC2 competed with TET1 in the binding of the RbAp46 protein at the promoters of maturation genes and knockdown of TET1 markedly prevented the activation of these genes. Collectively, our data not only demonstrated a novel intrinsic mechanism that the HDAC2-TET1 switch critically regulates iPS cell maturation, but also revealed an underlying mechanism of the interplay between histone acetylation and DNA demethylation in gene regulation. PMID:25934799

PS overcomes two serious magnet failures

CERN Multimedia

Maximilien Brice

2003-01-01

Two magnets and a bus bar connection in the PS were found to be faulty during high-voltage tests at the end of the accelerator shutdown. A five-week repair schedule was quickly devised. A team of mechanics, technicians and engineers worked at full speed to replace the faulty magnets, succeeding in limiting the delay of the accelerators' spring start-up to two weeks. Here we see the PS magnet string awaiting the replacement no. 6 magnet.

PS Control Room

CERN Multimedia

CERN PhotoLab

1963-01-01

The good old PS Control Room, all manual. For each parameter, a knob or a button to control it; for each, a light or meter or oscilloscope to monitor it; carefully written pages serve as the data bank; phones and intercom for communication. D.Dekkers is at the microphone, M.Valvini sits in front.

Prognostic significance of cytosolic pS2 content in ovarian tumors

International Nuclear Information System (INIS)

Raigoso, P.; Allende, T.; Zeidan, N.; Llana, B.; Bernardo, L.; Roiz, C.; Tejuca, S.; Vazquez, J.; Lamelas, M.L.

2002-01-01

Aim: pS2 is an estrogen regulated peptide which has been associated with a good prognosis an with a more favorable response to treatment in breast cancer patients. In ovarian tumors, the expression of pS2 was demonstrated at both mRNA and protein levels. In addition, it has been showed significant association of pS2 with mucinous differentiation or well differentiation grade of the tumors. However, it is little know about the prognostic significance of the pS2 content in ovarian carcinomas. The aims of the present work were to analyze the cytosolic pS2 content in benign and malignant ovarian tumors, its relationship with clinico-pathologic parameters, steroid receptor status, and prognostic significance. Material and Methods: We analysed the cytosolic concentrations of pS2 in 91 specimen ovarian tissues by an immunoradiometric assay (ELSA-pS2, CIS, France). The tissues were 8 normal ovaries, 43 benign tumors and 40 malignant ovarian tumors. The same ovarian tissues processed to pS2 were analyzed to Estrogen (ER) and Progesterone (PgR) Receptor status. These steroid receptors were quantified biochemically following commercial ELISA method (ABBOTT Diagnostics, Germany). The relationship between cytosolic content and clinico-pathologic factors was examined by the Mann-Whitney or Kruskall-Wallis test. Correlation between steroid receptors and pS2 content was calculated with the Spearman test. Survival curves were calculated using the Kaplan-Meier method and compared by the log-rank test. Differences were considered significant at 5% probability level. Results: pS2 could be detected in 30 cases (32.9%) with values ranged from 0.04 to 89 ng/mg prt. Only one normal ovary showed detectable levels of pS2 and there were not differences in cytosolic content between benign and malignant ovarian tumors. The pS2 levels were only associated to mucinous differentiation in both benign and malignant ovarian tumors (p=0.029 and p=0.015, respectively). Significantly higher

The new heart of the PS is beating strongly

CERN Multimedia

Corinne Pralavorio

2011-01-01

The PS has resumed operation with a brand new electrical power system called POPS; this enormous system comprising power electronics and capacitors is crucial because if it broke down practically no particles would be able to circulate at CERN. As soon as it started, POPS passed all the tests with flying colours and is now pulsing at full power.   The new PS power system is made up of 6 containers, each with 60 tonnes of capacitors and 8 power converters. The date 11/02/11 will always be remembered with affection by the engineers in the Electrical Power Converters Group. At 11:11 in the morning (no joke), the first beams powered by the new system began to circulate in the PS. The cutely-named POPS (POwer for PS) took over from the old rotating machine that had been working since 1968. From now on it will be POPS that supplies the PS main magnets with the electrical pulses needed to accelerate the beams for the LHC and all CERN's other facilities. The system is crucial as the PS is one of the lyn...

LEADIR-PS: the path to a safe and economic SMR

Energy Technology Data Exchange (ETDEWEB)

Hart, R.S. [Nothern Nuclear Industries Inc., Cambridge, Ontario (Canada)

2014-07-01

Northern Nuclear Industries Incorporated (N{sup 2} I{sup 2}) is developing a family of Small Modular Reactors (SMRs) called LEADIR-PS, an acronym for LEAD-cooled Integral Reactor-Passively Safe. LEADIR-PS plants under development, focused on process heat applications and the energy demands of Canada, are the LEADIR-PS100 with an output of 100 MWth and LEADIR-PS300 with an output of 300 MWth. A plant consisting of six LEADIR-PS300 reactor modules serving a common turbine-generator, called the LEADIR-PS Six-Pack, is focused on serving areas with higher energy demands. LEADIR-PS integrates the inherent safety features of the Modular High Temperature Gas Reactor and molten lead coolant in an integral pool type reactor configuration. Molten lead coolant, which boils at 1750 {sup o}C,avoids the cost of a reactor pressure vessel and high pressure/high temperature reactor coolant systems, and the safety concerns regarding pressure vessel and large capacity reactor coolant system piping rupture and precludes evaporation of the coolant. Molten lead does not chemically react with air, water, or graphite. The Gen IV+ LEADIR-PS plants are inherently/passively safe. There are no active systems required for safe shutdown and decay heat removal. Safety is assured without active or stored energy power supply, without a requirement to reposition valves or other devices and operator intervention or action. The unprecedented safety achieved by LEADIR-PS reactors avoids requirements for a large exclusion radius and demanding evacuation plan requirements. LEADIR-PS, with steam conditions of 370 {sup o}C and 12 MPa (more than twice that of water cooled reactors), can serve over 85% of the world's non-transportation process heat demands and is ideally suited to serving Combined Heat and Electricity demands and industrial parks. Energy utilization of over 95% is feasible in process heat and Combined Heat and Electricity applications. The simple robust design of LEADIR-PS plants in

Pressure Monitoring Using Hybrid fs/ps Rotational CARS

Science.gov (United States)

Kearney, Sean P.; Danehy, Paul M.

2015-01-01

We investigate the feasibility of gas-phase pressure measurements at kHz-rates using fs/ps rotational CARS. Femtosecond pump and Stokes pulses impulsively prepare a rotational Raman coherence, which is then probed by a high-energy 6-ps pulse introduced at a time delay from the Raman preparation. Rotational CARS spectra were recorded in N2 contained in a room-temperature gas cell for pressures from 0.1 to 3 atm and probe delays ranging from 10-330 ps. Using published self-broadened collisional linewidth data for N2, both the spectrally integrated coherence decay rate and the spectrally resolved decay were investigated as means for detecting pressure. Shot-averaged and single-laser-shot spectra were interrogated for pressure and the accuracy and precision as a function of probe delay and cell pressure are discussed. Single-shot measurement accuracies were within 0.1 to 6.5% when compared to a transducer values, while the precision was generally between 1% and 6% of measured pressure for probe delays of 200 ps or more, and better than 2% as the delay approached 300 ps. A byproduct of the pressure measurement is an independent but simultaneous measurement of the gas temperature.

The OMERACT psoriatic arthritis magnetic resonance imaging scoring system (PsAMRIS): definitions of key pathologies, suggested MRI sequences, and preliminary scoring system for PsA Hands

DEFF Research Database (Denmark)

Østergaard, Mikkel; McQueen, Fiona; Wiell, Charlotte

2009-01-01

This article describes a preliminary OMERACT psoriatic arthritis magnetic resonance image scoring system (PsAMRIS) for evaluation of inflammatory and destructive changes in PsA hands, which was developed by the international OMERACT MRI in inflammatory arthritis group. MRI definitions of important...... pathologies in peripheral PsA and suggestions concerning appropriate MRI sequences for use in PsA hands are also provided....

Nonlinear scattering in hard tissue studied with ultrashort laser pulses

International Nuclear Information System (INIS)

Eichler, J.; Kim, B.M.

2002-01-01

The back-scattered spectrum of ultrashort laser pulses (800 nm, 0.2 ps) was studied in human dental and other hard tissues in vitro below the ablation threshold. Frequency doubled radiation (SHG), frequency tripled radiation and two-photon fluorescence were detected. The relative yield for these processes was measured for various pulse energies. The dependence of the SHG signal on probe thickness was determined in forward and back scattering geometry. SHG is sensitive to linear polarization of the incident laser radiation. SHG in human teeth was studied in vitro showing larger signals in dentin than in cementum and enamel. In carious areas no SHG signal could be detected. Possible applications of higher harmonic radiation for diagnostics and microscopy are discussed. (orig.)

Energy and expectation values of the PsH system

International Nuclear Information System (INIS)

Mitroy, J.

2006-01-01

Close to converged energies and expectation values for PsH are computed using a ground state wave function consisting of 1800 explicitly correlated gaussians. The best estimate of the Ps ∞ H energy was -0.789 196 740 hartree which is the lowest variational energy to date. The 2γ annihilation rate for Ps ∞ H was 2.471 78x10 9 s -1

Emission properties of porphyrin compounds in new polymeric PS:CBP host

Science.gov (United States)

Jafari, Mohammad Reza; Bahrami, Bahram

2015-06-01

In this study, a device with fundamental structure of ITO/PEDOT:PSS (60 nm)/PS:CBP (70 nm)/Al (150 nm) was fabricated. The electroluminescence spectrum of device designated a red shift rather than PS:CBP photoluminescence spectra. It can be suggested that the electroplex emission occurs at PS:CBP interface. By following this step, red light-emitting devices using porphyrin compounds as a red dopant in a new host material PS:CBP with a configuration of ITO/PEDOT:PSS (60 nm)/PS:CBP:porphyrin compounds(70 nm)/Al (150 nm) have been fabricated and investigated. The electroluminescent spectra of the porphyrin compounds were red-shifted as compared with the PS:CBP blend. OLED devices based on doping 3,4PtTPP and TPPNO2 in PS:CBP showed purer red emission compared with ZnTPP and CoTPP doped devices. We believe that the electroluminescence performance of OLED devices based on porphyrin compounds depends on overlaps between the absorption of the porphyrin compounds and the emission of PS:CBP.

Small-angle neutron scattering from the reconstituted TF sub 1 of H sup + -ATPase from thermophilic bacterium PS3 with deuterated subunits

Energy Technology Data Exchange (ETDEWEB)

Ito, Yuji [Univ. of Tokyo (Japan) Brookhaven National Lab., Upton, NY (United States); Harada, Mitsuo [Univ. of Tokyo (Japan); Ohta, Shigeo; Kagawa, Yasuo; Aono, Osamu [Jichi Medical School, Tochigi (Japan); Schefer, J; Schoenborn, B P [Brookhaven National Lab., Upton (United States)

1990-01-01

Subunits {alpha}, {beta} and {gamma} of adenosine triphosphatase (H{sup +}-ATPase) from the thermophilic bacterium PS3 (TF{sub 1}) have been over-expressed in Escherichia coli. {alpha} and {beta} subunits deuterated to the level of 90% were obtained by culturing E. coli in {sup 2}H{sub 2}O medium. Both the subunits and the reconstituted {alpha}{beta}{gamma} complex, TF{sub 1}, which contain the deuterated components in various combinations, were studied in solution by small-angle neutron scattering. The individual shapes of the subunits and their organization in the {alpha}{beta}{gamma}-TF{sub 1} complex were examined using the techniques of selective deuteration and contrast variation. The {alpha} and {beta} subunits are well approximated as ellipsoids of revolution having minor semi-axes of 20{center dot}4({plus minus}0{center dot}4) and 20{center dot}0({plus minus}0{center dot}2) {angstrom}, and major semi-axes of 53{center dot}0({plus minus}1{center dot}4) and 55{center dot}8({plus minus}0{center dot}9) {angstrom}, respectively. In the TF{sub 1} complex, three {beta} subunits are aligned to form an equilateral triangle, with their major axes tilted by 35{degree} with respect to the 3-fold axis of the complex. The {beta}-{beta} distance is about 53 {angstrom}. Three {alpha} subunits are similarly arranged, positioned between the {beta} subunits, and with their direction of tilt opposite to that of the {beta} subunits. The centers of the {alpha} and {beta} subunits lie in the same plane, forming a hexagon. Adjacent subunits overlap in this model, suggesting that they are not simple ellipsoids of revolution.

A depressão na economia dos processos de diferenciação e integração psíquicas

Directory of Open Access Journals (Sweden)

Daniel Delouya

Full Text Available Interrogados sobre as questões atuais acerca da depressão – tema proposto para a primeira jornada desta revista –, o presente trabalho sugere que a depressão nos permite relançar as questões cruciais em relação à dimensão econômica do aparelho psíquico, integrando-a a outras, tópica e dinâmica, do mesmo. A depressão encontra-se no cerne de um princípio que, em analogia à biologia, condiciona e possibilita o surgimento da vida e sua permanência. Ou seja, abriga dentro dela um princípio paralelo ao que rege, na termodinâmica, a tendência negentrópica. Em outras palavras, ela conduz a construção da vida psíquica através das duas classes de processos que possibilitam, nesta analogia, a vida: diferenciação e integração. Alguns momentos e vinhetas clínicas são trazidos como ilustração desses processos.

Chemotherapy and quality of life in NSCLC PS 2 patients

DEFF Research Database (Denmark)

Helbekkmo, Nina; Strøm, Hans H; Sundstrøm, Stein H

2009-01-01

, fatigue, dyspnea, sleeping problems and appetite loss in comparison to the PS 0/1 group. CONCLUSIONS: PS 2 NSCLC patients seem to achieve valuable HRQOL benefits from platinum-based combination therapy. Prospective clinical studies with predefined HRQOL outcomes in PS 2 patients are needed to confirm...

Landslide Activity Maps Generation by Means of Persistent Scatterer Interferometry

Directory of Open Access Journals (Sweden)

Silvia Bianchini

2013-11-01

Full Text Available In this paper a methodology is proposed to elaborate landslide activity maps through the use of PS (Persistent Scatterer data. This is illustrated through the case study of Tramuntana Range in the island of Majorca (Spain, where ALOS (Advanced Land Observing Satellite images have been processed through a Persistent Scatterer Interferometry (PSI technique during the period of 2007–2010. The landslide activity map provides, for every monitored landslide, an assessment of the PS visibility according to the relief, land use, and satellite acquisition parameters. Landslide displacement measurements are projected along the steepest slope, in order to compare landslide velocities with different slope orientations. Additionally, a ground motion activity map is also generated, based on active PS clusters not included within any known landslide phenomenon, but even moving, potentially referred to unmapped landslides or triggered by other kinds of geomorphological processes. In the Tramuntana range, 42 landslides were identified as active, four as being potential to produce moderate damage, intersecting the road Ma-10, which represents the most important road of the island and, thus, the main element at risk. In order to attest the reliability of measured displacements to represent landslide dynamics, a confidence degree evaluation is proposed. In this test site, seven landslides exhibit a high confidence degree, medium for 93 of them, and low for 51. A low confidence degree was also attributed to 615 detected active clusters with a potential to cause moderate damage, as their mechanism of the triggering cause is unknown. From this total amount, 18 of them intersect the Ma-10, representing further potentially hazardous areas. The outcomes of this work reveal the usefulness of landslide activity maps for environmental planning activities, being exportable to other radar data and different geomorphological settings.

The permanent process

DEFF Research Database (Denmark)

Møller, Jesper; McCullagh, Peter

We extend the boson process first to a large class of Cox processes and second an even larger class of infinitely divisible point processes. Density and moment results are studied in detail. These results are obtained in closed form as weighted permanents, so the extension is called a permanent...... process. Temporal extensions and a particularly tractable case of the permanent process are also studied. Extensions of the ferminon process along similar lines, leading to so-called determinant processes, are discussed at the end. While the permanent process is attractive, the determinant process...

PS Main Control Room (partial view)

CERN Multimedia

1974-01-01

Jean-Pierre Potier (turning buttons) and Bertran Frammery (telephoning) on shift. The 26 GeV Synchrotron and later also its related machines (Linacs 1,2,3; PS-Booster; LEP-Injector Linacs and Electron-Positron Accumulator; Antiproton Accumulator, Antiproton Collector, Low Energy Antiproton Ring and more recently Antiproton Decelerator) were all controlled from the PS control room situated on the Meyrin site. The SPS and LEP were controlled from a separat control centre on the Prevessin site. In 2005 all controls were transferred to the Prevessin centre.

PS overcomes two serious magnet failures

CERN Multimedia

Maximilien Brice

2003-01-01

Two magnets and a bus bar connection in the PS were found to be faulty during high-voltage tests at the end of the accelerator shutdown. A five-week repair schedule was quickly devised. A team of mechanics, technicians and engineers worked at full speed to replace the faulty magnets, succeeding in limiting the delay of the accelerators' spring start-up to two weeks. These pictures show one of the magnets (no. 19) on the PS locomotive brought back into service for the removal and replacement operations.

Slope instability mapping around L'Aquila (Abruzzo, Italy) with Persistent Scatterers Interferometry from ERS, ENVISAT and RADARSAT datasets

Science.gov (United States)

Righini, Gaia; Del Conte, Sara; Cigna, Francesca; Casagli, Nicola

2010-05-01

In the last decade Persistent Scatterers Interferometry (PSI) was used in natural hazards investigations with significant results and it is considered a helpful tool in ground deformations detection and mapping (Berardino et. al., 2003; Colesanti et al., 2003; Colesanti & Wasowski, 2006; Hilley et al., 2004). In this work results of PSI processing were interpreted after the main seismic shock that affected the Abruzzo region (Central Italy) on 6th of April 2009, in order to carry out a slope instability mapping according to the requirement of National Department of Civil Protection and in the framework of the Landslides thematic services of the EU FP7 project ‘SAFER' (Services and Applications For Emergency Response - Grant Agreement n° 218802). The area of interest was chosen in almost 460 km2 around L'Aquila according the highest probability of reactivations of landslides which depends on the local geological conditions, on the epicenter location and on other seismic parameters (Keefer, 1984). The radar images datasets were collected in order to provide estimates of the mean yearly velocity referred to two distinct time intervals: historic ERS (1992-2000) and recent ENVISAT (2002-2009), RADARSAT (2003-2009); the ERS and RADARSAT images were processed by Tele-Rilevamento Europa (TRE) using PS-InSAR(TM) technique, while the ENVISAT images were processed by e-GEOS using PSP-DIFSAR technique. A pre-existing landslide inventory map was updated through the integration of conventional photo interpretation and the radar-interpretation chain, as defined by Farina et al. (2008) and reported in literature (Farina et al. 2006, Meisina et al. 2007, Pancioli et al., 2008; Righini et al., 2008, Casagli et al., 2008, Herrera et al., 2009). The data were analyzed and interpreted in Geographic Information System (GIS) environment. Main updates of the pre-existing landslides are focusing on the identification of new landslides, modification of boundaries through the spatial

Beyond iPS!

Directory of Open Access Journals (Sweden)

Editorial

2012-01-01

Full Text Available It’s undoubtedly a jubilant moment for scientists and clinicians working in the stem cell arena as Prof. Gurdon and Prof. Shinya Yamanaka have been chosen for the Nobel Prize in Physiology & Medicine this year. The mystery of cell biology is something unfathomable and probably the work of this duo as well as the other scientists, who have put their hands on in- vitro de-differentiation have opened our eyes to a new window or a new paradigm in cell biology. The iPS invention has brought a lot of hope in terms of potential direct benefits to treat several diseases, which have no definite options at the moment. But, we envisage that several spin-offs could come out of this invention and one very significant spin-off finding recently witnessed is the finding by Prof. Masaharu Seno and his team of researchers at the Okayama University, Japan (Chen L, et al. 2012, PLoS ONE 7(4:e33544.doi:10.1371/journal.pone.0033544. According to Prof. Seno, mouse iPS cells (miPS when cultured in the conditioned medium derived from cancer cell lines, differentiate into cancer stem cells (CSCs. While differentiating into CSCs, they do retain the potential to develop endothelial progenitor cells. Several questions arise here: 1.Are these miPS derived CSCs really pluripotent, even if the terminal differentiation destined to specific phenotypes? 2.Shouldn’t the Cancer Stem Cells be termed as cancer progenitor cells, as till date they are considered to be producing only cancer cells but not pluripotent to yield other types of normal tissues? The spin-offs could be infinite as the process of differentiation and de-differentiation happening due to trillions of signals and pathways, most still remaining not-so-well understood. A special mention should be made to Prof. Shinya Yamanaka as he has several sterling qualities to be a role-model for budding scientists. Apart from his passion for science, which made him shift his career from orthopedics to a cell biologist, his

PS auxiliary magnet

CERN Multimedia

CERN PhotoLab

1974-01-01

Units of the PS auxiliary magnet system. The picture shows how the new dipoles, used for vertical and horizontal high-energy beam manipulation, are split for installation and removal so that it is not necessary to break the accelerator vacuum. On the right, adjacent to the sector valve and the windings of the main magnet, is an octupole of the set.

Multi - band Persistent Scatterer Interferometry data integration for landslide analysis

Science.gov (United States)

Bianchini, Silvia; Mateos, Rosa; Mora, Oscar; García, Inma; Sánchez, Ciscu; Sanabria, Margarita; López, Maite; Mulas, Joaquin; Hernández, Mario; Herrera, Gerardo

2013-04-01

We present a methodology to perform a geomorphological assessment of ground movements over wide areas, by improving Persistent Scatterer Interferometry (PSI) analysis for landslide studies. The procedure relies on the integrated use of multi-band EO data acquired by different satellite sensors in different time intervals, to provide a detailed investigation of ground displacements. The methodology, throughout the cross-comparison and integration of PS data in different microwave bands (ALOS in L-band, ERS1/2 and ENVISAT in C-band, COSMOSKY-MED in X-band), is applied on the Tramontana Range in the northwestern part of Mallorca island (Spain), extensively affected by mass movements across time, especially during the last years. We increase the confidence degree of the available interferometric data and we homogenize all PS targets by implementing and classifying them through common criteria. Therefore, PSI results are combined with geo-thematic data and pre-existing landslide inventories of the study area, in order to improve the landslide database, providing additional information on the detected ground displacements. The results of this methodology are used to elaborate landslide activity maps, permitting to jointly exploit heterogeneous PS data for analyzing landslides at regional scale. Moreover, from a geomorphological perspective, the proposed approach exploits the implemented PS data to achieve a reliable spatial analysis of movement rates, whatever referred to certain landslide phenomena or to other natural processes, in order to perform ground motion activity maps within a wide area.

In Situ GISAXS Study on Solvent Vapour Induced Orientation Switching in PS-b-P4VP Block Copolymer Thin Films

International Nuclear Information System (INIS)

Gowd, E Bhoje; Boehme, Marcus; Stamm, Manfred

2010-01-01

We investigated the orientation changes of cylindrical P4VP microdomains in PS-b-P4VP thin films upon annealing in different solvent vapours using the time-resolved in situ grazing-incidence small-angle X-ray scattering (GISAXS) for the first time. Swelling of perpendicular cylinders (C perpendicular) in a non-selective solvent vapours (chloroform) leads to the orientation change to in-plane cylinders (C//) and it occurs through a disordered state. On the other hand, swelling of perpendicular cylinders (C perpendicular) in a selective solvent vapours (1,4-dioxane) leads the morphological change from cylindrical to BCC spherical morphology. Solvent evaporation results in shrinkage of the matrix in the vertical direction and subsequently merges the spheres into the perpendicularly aligned cylinders. The selectivity of the solvent to constituting blocks and the solvent evaporation rate may be mainly responsible for such orientation change of cylindrical P4VP microdomains in PS-b-P4VP thin films.

In Situ GISAXS Study on Solvent Vapour Induced Orientation Switching in PS-b-P4VP Block Copolymer Thin Films

Energy Technology Data Exchange (ETDEWEB)

Gowd, E Bhoje; Boehme, Marcus; Stamm, Manfred, E-mail: gowd@ipfdd.de, E-mail: bhojegowd@yahoo.com [Department of Nanostructured Materials Leibniz Institute of Polymer Research Dresden Hohe Strasse 6, 01069, Dresden (Germany)

2010-11-15

We investigated the orientation changes of cylindrical P4VP microdomains in PS-b-P4VP thin films upon annealing in different solvent vapours using the time-resolved in situ grazing-incidence small-angle X-ray scattering (GISAXS) for the first time. Swelling of perpendicular cylinders (C perpendicular) in a non-selective solvent vapours (chloroform) leads to the orientation change to in-plane cylinders (C//) and it occurs through a disordered state. On the other hand, swelling of perpendicular cylinders (C perpendicular) in a selective solvent vapours (1,4-dioxane) leads the morphological change from cylindrical to BCC spherical morphology. Solvent evaporation results in shrinkage of the matrix in the vertical direction and subsequently merges the spheres into the perpendicularly aligned cylinders. The selectivity of the solvent to constituting blocks and the solvent evaporation rate may be mainly responsible for such orientation change of cylindrical P4VP microdomains in PS-b-P4VP thin films.

Exact PsTd invariant and PsTd symmetric breaking solutions, symmetry reductions and Bäcklund transformations for an AB-KdV system

Science.gov (United States)

Jia, Man; Lou, Sen Yue

2018-05-01

In natural and social science, many events happened at different space-times may be closely correlated. Two events, A (Alice) and B (Bob) are defined as correlated if one event is determined by another, say, B = f ˆ A for suitable f ˆ operators. A nonlocal AB-KdV system with shifted-parity (Ps, parity with a shift), delayed time reversal (Td, time reversal with a delay) symmetry where B =Ps ˆ Td ˆ A is constructed directly from the normal KdV equation to describe two-area physical event. The exact solutions of the AB-KdV system, including PsTd invariant and PsTd symmetric breaking solutions are shown by different methods. The PsTd invariant solution show that the event happened at A will happen also at B. These solutions, such as single soliton solutions, infinitely many singular soliton solutions, soliton-cnoidal wave interaction solutions, and symmetry reduction solutions etc., show the AB-KdV system possesses rich structures. Also, a special Bäcklund transformation related to residual symmetry is presented via the localization of the residual symmetry to find interaction solutions between the solitons and other types of the AB-KdV system.

A modulated differential scanning calorimetry and small-angle x-ray scattering study of the interfacial region in structured latices

Directory of Open Access Journals (Sweden)

Hourston Douglas J.

2001-01-01

Full Text Available The interfacial structure of poly(styrene (PS-poly(methyl acrylate (PMA structured latices has been investigated by means of modulated-temperature differential scanning calorimetry (M-TDSC and small-angle x-ray scattering (SAXS. The differential of heat capacity, dCp/dT, signal from M-TDSC was used to quantify the weight fraction of interface in these latices. For PS-PMA (50:50 by weight structured latices in which the PS component had different crosslink densities (0, 1, 3, 5 and 10 mol% of crosslinking agent, the weight fraction of interface was about 13%. With increasing crosslink density, the fraction of interface increased only slightly. A core-shell model has been used to analyse SAXS data for these PS-PMA latices. M-TDSC can only provide information about the weight fraction of interface, but the combination of M-TDSC and SAXS can provide much more information on the morphology of such structured latices.

Annihilation probability density and other applications of the Schwinger multichannel method to the positron and electron scattering

International Nuclear Information System (INIS)

Varella, Marcio Teixeira do Nascimento

2001-12-01

We have calculated annihilation probability densities (APD) for positron collisions against He atom and H 2 molecule. It was found that direct annihilation prevails at low energies, while annihilation following virtual positronium (Ps) formation is the dominant mechanism at higher energies. In room-temperature collisions (10 -2 eV) the APD spread over a considerable extension, being quite similar to the electronic densities of the targets. The capture of the positron in an electronic Feshbach resonance strongly enhanced the annihilation rate in e + -H 2 collisions. We also discuss strategies to improve the calculation of the annihilation parameter (Z eff ), after debugging the computational codes of the Schwinger Multichannel Method (SMC). Finally, we consider the inclusion of the Ps formation channel in the SMC and show that effective configurations (pseudo eigenstates of the Hamiltonian of the collision ) are able to significantly reduce the computational effort in positron scattering calculations. Cross sections for electron scattering by polyatomic molecules were obtained in three different approximations: static-exchange (SE); tatic-exchange-plus-polarization (SEP); and multichannel coupling. The calculations for polar targets were improved through the rotational resolution of scattering amplitudes in which the SMC was combined with the first Born approximation (FBA). In general, elastic cross sections (SE and SEP approximations) showed good agreement with available experimental data for several targets. Multichannel calculations for e - -H 2 O scattering, on the other hand, presented spurious structures at the electronic excitation thresholds (author)

Resonances above the ionization threshold in positron-hydrogen scattering

International Nuclear Information System (INIS)

Kernoghan, A.A.; Walters, H.R.J.; McAlinden, M.T.

1994-01-01

Resonances appearing above the ionization threshold in coupled-state calculations of positron-atom scattering are discussed. Calculations in the six state approximation Ps(1s, 2s, 2p) + H(1s, 2s, 2p), which show such resonance structure, are compared with a more extensive 18-state approximation Ps(1s, 2s, 3s, 4s, 2p, 3p, 4p, 3d, 4d) + H(1s, 2s, 3s, 4s, 2p, 3p, 4p, 3d, 4d) in which channels other than 1s, 2s and 2p are represented by pseudostates. The results strongly indicate that the above ionization threshold resonances observed in the six-state approximation, and in other small basis set calculations, are not real. It is suggested that they are a consequence of the neglect, or inadequate representation in other approximations, of ionization channels. In the six-state approximation the positronium component of the system wavefunction attempts to represent the missing ionization channels but in so doing produces unreal resonances above the ionization threshold. More generally it is suggested that, in coupled-state calculations of positron-atom scattering, the atom part of the system wavefunction will try to compensate for defects in the positronium component and vice versa. When the defects are serious, for example, the omission of important ionization channels, unusual spurious behaviour is to be expected. (Author)

PS-Modules over Ore Extensions and Skew Generalized Power Series Rings

Directory of Open Access Journals (Sweden)

Refaat M. Salem

2015-01-01

Full Text Available A right R-module MR is called a PS-module if its socle, SocMR, is projective. We investigate PS-modules over Ore extension and skew generalized power series extension. Let R be an associative ring with identity, MR a unitary right R-module, O=Rx;α,δ Ore extension, MxO a right O-module, S,≤ a strictly ordered additive monoid, ω:S→EndR a monoid homomorphism, A=RS,≤,ω the skew generalized power series ring, and BA=MS,≤RS,≤, ω the skew generalized power series module. Then, under some certain conditions, we prove the following: (1 If MR is a right PS-module, then MxO is a right PS-module. (2 If MR is a right PS-module, then BA is a right PS-module.

Proceedings of the workshop on the PS-spin collider

International Nuclear Information System (INIS)

Mori, Yoshiharu

1993-05-01

This volume is a record of the PS-Spin Collider Workshop which was held at KEK, Jan. 31-Feb.1, 1992. As a future project of the KEK 12-GeV proton synchrotron (KEK-PS), the hadron collider (PS-Collider), has been under discussion. Originally, the PSC was designed for heavy ion beam collisions with the energy range of 5-7 GeV/u. If polarized protons are accelerated in PSC, 19 x 19 GeV collisions are possible. This workshop was proposed to bring together interested experimentalists and accelerator physicists to discuss the case that could be made for polarization physics and the technical feasibility at the PS Spin Collider. More than 30 physicists participated in the workshop and very interesting and useful discussions took place. (author)

The Question of Decalage Between Object Permanence and Person Permanence

Science.gov (United States)

And Others; Jackson, Elaine

1978-01-01

Presents a study of decalage between object permanence and person permanence. Decalage was influenced by environmental as well as stimulus factors with infants tested between 6- and 81/4-months/of-age. (BD)

Essure Permanent Birth Control

Science.gov (United States)

... Prosthetics Essure Permanent Birth Control Essure Permanent Birth Control Share Tweet Linkedin Pin it More sharing options ... Print Essure is a a permanently implanted birth control device for women (female sterilization). Implantation of Essure ...

Efficient surface enhanced Raman scattering on confeito-like gold nanoparticle-adsorbed self-assembled monolayers.

Science.gov (United States)

Chang, Chia-Chi; Imae, Toyoko; Chen, Liang-Yih; Ujihara, Masaki

2015-12-28

Confeito-like gold nanoparticles (AuNPs; average diameter = 80 nm) exhibiting a plasmon absorption band at 590 nm were adsorbed through immersion-adsorption on two self-assembled monolayers (SAMs) of 3-aminopropyltriethoxysilane (APTES-SAM) and polystyrene spheres coated with amine-terminated poly(amido amine) dendrimers (DEN/PS-SAM). The surface enhanced Raman scattering (SERS) effect on the SAM substrates was examined using the molecules of a probe dye, rhodamine 6G (R6G). The Raman scattering was strongly intensified on both substrates, but the enhancement factor (>10,000) of the AuNP/DEN/PS-SAM hierarchy substrate was 5-10 times higher than that of the AuNP/APTES-SAM substrate. This strong enhancement is attributed to the large surface area of the substrate and the presence of hot spots. Furthermore, analyzing the R6G concentration dependence of SERS suggested that the enhancement mechanism effectively excited the R6G molecules in the first layer on the hot spots and invoked the strong SERS effect. These results indicate that the SERS activity of confeito-like AuNPs on SAM substrates has high potential in molecular electronic devices and ultrasensitive analyses.

Multi-temporal InSAR Datastacks for Surface Deformation Monitoring: a Review

Science.gov (United States)

Ferretti, A.; Novali, F.; Prati, C.; Rocca, F.

2009-04-01

In the last decade extensive processing of thousands of satellite radar scenes acquired by different sensors (e.g. ERS-1/2, ENVISAT and RADARSAT) has demonstrated how multi-temporal data-sets can be successfully exploited for surface deformation monitoring, by identifying objects on the terrain that have a stable, point-like behaviour. These objects, referred to as Permanent or Persistent Scatterers (PS), can be geo-coded and monitored for movement very accurately, acting as a "natural" geodetic network, integrating successfully continuous GPS data. After a brief analysis of both advantages and drawbacks of InSAR datastacks, the paper presents examples of applications of PS measurements for detecting and monitoring active faults, aquifers and oil/gas reservoirs, using experience in Europe, North America and Japan, and concludes with a discussion on future directions for PSInSAR analysis. Special attention is paid to the possibility of creating deformation maps over wide areas using historical archives of data already available. This second part of the paper will briefly discuss the technical features of the new radar sensors recently launched (namely: TerraSAR-X, RADARSAT-2, and CosmoSkyMed) and their impact on space geodesy, highlighting the importance of data continuity and standardized acquisition policies for almost all InSAR and PSInSAR applications. Finally, recent advances in the algorithms applied in PS analysis, such as detection of "temporary PS", PS characterization and exploitation of distributed scatterers, will be briefly discussed based on the processing of real data.

Omega-conotoxin- and nifedipine-insensitive voltage-operated calcium channels mediate K(+)-induced release of pro-thyrotropin-releasing hormone-connecting peptides Ps4 and Ps5 from perifused rat hypothalamic slices.

Science.gov (United States)

Valentijn, K; Tranchand Bunel, D; Vaudry, H

1992-07-01

The rat thyrotropin-releasing hormone (TRH) precursor (prepro-TRH) contains five copies of the TRH progenitor sequence linked together by intervening sequences. Recently, we have shown that the connecting peptides prepro-TRH-(160-169) (Ps4) and prepro-TRH-(178-199) (Ps5) are released from rat hypothalamic neurones in response to elevated potassium concentrations, in a calcium-dependent manner. In the present study, the role of voltage-operated calcium channels in potassium-induced release of Ps4 and Ps5 was investigated, using a perifusion system for rat hypothalamic slices. The release of Ps4 and Ps5 stimulated by potassium (70 mM) was blocked by the inorganic ions Co2+ (2.6 mM) and Ni2+ (5 mM). In contrast, the stimulatory effect of KCl was insensitive to Cd2+ (100 microM). The dihydropyridine antagonist nifedipine (10 microM) had no effect on K(+)-evoked release of Ps4 and Ps5. Furthermore, the response to KCl was not affected by nifedipine (10 microM) in combination with diltiazem (1 microM), a benzothiazepine which increases the affinity of dihydropyridine antagonists for their receptor. The dihydropyridine agonist BAY K 8644, at concentrations as high as 1 mM, did not stimulate the basal secretion of Ps4 and Ps5. In addition, BAY K 8644 had no potentiating effect on K(+)-induced release of Ps4 and Ps5. The marine cone snail toxin omega-conotoxin, a blocker of both L- and N-type calcium channels had no effect on the release of Ps4 and Ps5 stimulated by potassium. Similarly, the omega-conopeptide SNX-111, a selective blocker of N-type calcium channels, did not inhibit the stimulatory effect of potassium. The release of Ps4 and Ps5 evoked by high K+ was insensitive to the non-selective calcium channel blocker verapamil (20 microM). Amiloride (1 microM), a putative blocker of T-type calcium channels, did not affect KCl-induced secretion of the two connecting peptides. Taken together, these results indicate that two connecting peptides derived from the pro-TRH, Ps

Atomic scattering from an adsorbed monolayer solid with a helium beam that penetrates to the substrate

DEFF Research Database (Denmark)

Hansen, Flemming Yssing; Bruch, L.W.; Dammann, Bernd

2013-01-01

Diffraction and one-phonon inelastic scattering of a thermal energy helium atomic beam are evaluated in the situation that the target monolayer lattice is so dilated that the atomic beam penetrates to the interlayer region between the monolayer and the substrate. The scattering is simulated......(1 × 1) commensurate monolayer solid of H2/KCl(001). For the latter, there are cases where part of the incident beam is trapped in the interlayer region for times exceeding 50 ps, depending on the spacing between the monolayer and the substrate and on the angle of incidence. The feedback effect...

Permanences GAG-EPA

CERN Document Server

GAC-EPA

2015-01-01

Le GAC organise chaque mois des permanences avec entretiens individuels. La prochaine permanence se tiendra le : Mardi 5 mai de 13 h 30 à 16 h 00 Salle de réunion de l’Association du personnel Les permanences suivantes auront lieu les mardis 2 juin, 1er septembre, 6 octobre, 3 novembre et 1er décembre 2015. Les permanences du Groupement des Anciens sont ouvertes aux bénéficiaires de la Caisse de pensions (y compris les conjoints survivants) et à tous ceux qui approchent de la retraite. Nous invitons vivement ces derniers à s’associer à notre groupement en se procurant, auprès de l’Association du personnel, les documents nécessaires.

New safety training for access to the PS complex areas

CERN Multimedia

2012-01-01

Since 10/08/2012, a new course dedicated to the specific radiological risks in the accelerators of the PS complex has been available on SIR (https://sir.cern.ch/). This course complements the general classroom-based Radiation Safety training. Successful completion of the course will be obligatory and verified by the access system as from 01/11/2012 for access to the following accelerator areas: LINAC2, BOOSTER, PS and TT2. Information and reminder e-mails will be sent to all persons currently authorized to access the accelerators of the PS complex. For questions please contact the HSE unit and in particular, the Radiation Protection Group (+41227672504 or safety-rp-ps-complex@cern.ch).

Quasielastic neutron scattering measurements and ab initio MD-simulations on single ion motions in molten NaF

Energy Technology Data Exchange (ETDEWEB)

Demmel, F. [ISIS Facility, Rutherford Appleton Laboratory, Didcot OX11 0QX (United Kingdom); Mukhopadhyay, S. [ISIS Facility, Rutherford Appleton Laboratory, Didcot OX11 0QX (United Kingdom); Department of Materials, Imperial College London, Exhibition Road, London SW7 2AZ (United Kingdom)

2016-01-07

The ionic stochastic motions in the molten alkali halide NaF are investigated by quasielastic neutron scattering and first principles molecular dynamics simulation. Quasielastic neutron scattering was employed to extract the diffusion behavior of the sodium ions in the melt. An extensive first principles based simulation on a box of up to 512 particles has been performed to complement the experimental data. From that large box, a smaller 64-particle box has then been simulated over a runtime of 60 ps. A good agreement between calculated and neutron data on the level of spectral shape has been obtained. The obtained sodium diffusion coefficients agree very well. The simulation predicts a fluorine diffusion coefficient similar to the sodium one. Applying the Nernst-Einstein equation, a remarkable large cross correlation between both ions can be deduced. The velocity cross correlations demonstrate a positive correlation between the ions over a period of 0.1 ps. That strong correlation is evidence that the unlike ions do not move completely statistically independent and have a strong association over a short period of time.

The PS booster

CERN Multimedia

CERN PhotoLab

1972-01-01

The PS booster which accelerates protons from the linac at an energy of 50 MeV to an energy of 800 MeV before injecting them into the main magnet ring of the synchrotron. The booster consists of four superposed rings. In the photograph can be seen the input beam line from the linac and the output beam lines, where beams from the four booster levels have been combined into two beams before final recombination.

Delay-line cables for the fast bumpers in the PS.

CERN Multimedia

CERN PhotoLab

1976-01-01

For 'continuous transfer' to the SPS, the beam accelerated in the PS is shaved off over several turns, so as to form a continuous sequence of bunches several times the length of the PS circumference. Fast bumpers, powered in a 'staircase' way, displace the PS beam stepwise towards the ejection septum. Each step lasts 2.1 microsec and the cable drums in this picture contain some of the bumper delay-lines of altogether 10 km.

Dynamics of Kilauea's Magmatic System Imaged Using a Joint Analysis of Geodetic and Seismic Data

Science.gov (United States)

Wauthier, C.; Roman, D. C.; Poland, M. P.; Fukushima, Y.; Hooper, A. J.

2012-12-01

Nowadays, Interferometric Synthetic Aperture Radar (InSAR) is commonly used to study a wide range of active volcanic areas. InSAR provides high-spatial-resolution measurements of surface deformation with centimeter-scale accuracy. At Kilauea Volcano, Hawai'i, InSAR shows complex processes that are not well constrained by GPS data (which have relatively poor spatial resolution). However, GPS data have higher temporal resolution than InSAR data. Both datasets are thus complementary. To overcome some of the limitations of conventional InSAR, which are mainly induced by temporal decorrelation, topographic, orbital and atmospheric delays, a Multi-Temporal InSAR (MT-InSAR) approach can be used. MT-InSAR techniques involve the processing of multiple SAR acquisitions over the same area. Two classes of MT-InSAR algorithms are defined: the persistent scatterers (PS) and small baseline (SBAS) methods. Each method is designed for a specific type of scattering mechanism. A PS pixel is a pixel in which a single scatterer dominates, while the contributions from other scatterers are negligible. A SBAS pixel is a pixel that includes distributed scatterers, which have a phase with little decorrelation over short time periods. Here, we apply the "StaMPS" ("Stanford Method for Permanent Scatterers") technique, which incorporates both a PS and SBAS approach, on ENVISAT and ALOS datasets acquired from 2003 to 2010 at Kilauea. In particular, we focus our InSAR analysis on the time period before the June 2007 "Father's Day" dike intrusion and eruption, and also incorporate seismic and GPS data in our models. Our goal is to identify any precursors to the Father's Day event within Kilauea's summit magma system, east rift zone, and/or southwest rift zone.

Differential expression of GSK3β and pS9GSK3β in normal human tissues: can pS9GSK3β be an epithelial marker?

Science.gov (United States)

Lee, Hojung; Ro, Jae Y

2015-01-01

Glycogen synthase kinase 3β (GSK3β) and phosphorylated GSK3β at Ser9 (pS9GSK3β) are crucial in cellular proliferation and metabolism. GSK3β and pS9GSK3β are deregulated in many diseases including tumors. Data on altered expression of GSK3β and pS9GSK3β are mainly limited to tumor tissues, thus the expression of GSK3β and pS9GSK3β in normal human tissue has been largely unknown. Thus, we examined the immunohistochemical localization of GSK3β and pS9GSK3β in human fetal and adult tissues, and also compared the expression pattern of GSK3β and pS9GSK3β with that of the CK7 and CK20. We found GSK3β expression in neurons of brain, myenteric plexus in gastrointestinal tract, squamous epithelium of skin, and mammary gland. The expression of pS9GSK3β was restricted to the epithelial cells of breast and pancreaticobiliary duct, distal nephron of kidney, gastrointestinal tract, fallopian tube, epididymis, secretory cell of prostatic gland, and umbrella cell of urinary tract. The staining pattern of pS9GSK3β and CK7 was overlapped in most organs except for gastrointestinal tract where CK7 was negative and CK20 was positive. Our results show that the expression of GSK3β may be associated with differentiation of ectodermal derived tissues and pS9GSK3β with that of epithelial cells of endodermal derived tissues in human. In addition, the expression of pS9GSK3β in the selective epithelial cells may indicate its association with secretory or barrier function of specific cells and may serve as another immunohistochemical marker for epithelial cells.

Motor-generator set of the PS main supply

CERN Multimedia

Photographic Service; CERN PhotoLab

1968-01-01

Already in 1964, the PS improvement programme included a new main magnet supply with more power for the longer cycles needed for slow extraction at the full energy of 26 GeV. This motor-generator set was installed in 1967 and took up service at the beginning of 1968. Regularly serviced and fitted with modern electronic regulation, it pulses the PS to this day.

Interleaving of beam lines inside the PS tunnel

CERN Multimedia

1983-01-01

View against the direction of the proton beams. The PS ring (section 26) is on the left. The injection tunnel for LEAR leaving from here has increased the trafic in this already busy area where the two Linacs and the transfer tunnel leading to the SPS, ISR and AA join the PS ring (cf. photo 7802260, 7802261, Annual Report 1981, p. 89, fig. 12).

Improvement of the bandwidth of the transient digitizers in the LIDAR Thomson scattering diagnostic on JET

International Nuclear Information System (INIS)

Kristensen, E.

1990-06-01

The main limitation on the spatial resolution of the LIDAR Thomson scattering diagnostic on the JET tokamak is due to the narrow bandwidth of the detection system. The transient digitizers, Tektronik 7912AD, are the main contributors to the narrow bandwidth. It is shown how the digitizers can be modified to improve the response time from approx. 480 to 410 ps. (author)

A transmissão psíquica geracional

Directory of Open Access Journals (Sweden)

Vinícius Oliveira dos Santos

Full Text Available O artigo seguinte refere-se a um estudo sobre como ocorre a transmissão psíquica entre as gerações e qual sua importância na constituição psíquica do sujeito. É também objetivo deste artigo explicar o que são as transmissões intergeracional e transgeracional. Para buscar respostas para essas questões, fez-se uma pesquisa bibliográfica sobre a transmissão psíquica, pelo viés psicanalítico, principalmente a partir da teoria lacaniana e com conceitos oriundos da linguística saussuriana. Será a partir de uma determinada ordem simbólica, constituída pela linguagem que precede o sujeito, nomeado por Lacan como o Outro, que a transmissão psíquica entre gerações ganhará o seu caráter unívoco, sempre se tendo em mente a importância fundamental do recalcamento e de seus efeitos, bem como do retorno do recalcado nas diferentes gerações. A transmissão psíquica é necessária e concomitante à constituição do sujeito, e ocorre através da linguagem, dos significantes que irão determinar uma ordem simbólica para o ser que nasce através dos diferentes discursos que perpassam as gerações nas figuras dos pais desse novo ser. Essa ordem simbólica continuará a se fazer presente nesse novo sujeito pelo restante de sua existência. Este artigo busca dar nova luz ao aspecto da transmissão psíquica transgeracional, diferenciando-se da recalque s abordagens psicanalíticas contemporâneas por ser uma leitura lacaniana. Serão usados dois exemplos: um de como a transmissão aparece na cultura, outro, na subjetividade do sujeito através da arte.

The PS Booster, PS and SPS Magnets for the next 25 years

CERN Document Server

Tommasini, D

2010-01-01

This note provides information and analysis on the present status of the magnets installed in the CERN Proton Synchrotron Booster (PSB), the Proton Synchrotron (PS) and the Super Proton Synchrotron (SPS) in view of their possible operation for the next 25 years. The note does not cover the magnets installed in the transfer lines, neither it covers the fast injection/extraction magnets (septa and kickers).

Probability-of-Superiority SEM (PS-SEM—Detecting Probability-Based Multivariate Relationships in Behavioral Research

Directory of Open Access Journals (Sweden)

Johnson Ching-Hong Li

2018-06-01

Full Text Available In behavioral research, exploring bivariate relationships between variables X and Y based on the concept of probability-of-superiority (PS has received increasing attention. Unlike the conventional, linear-based bivariate relationship (e.g., Pearson's correlation, PS defines that X and Y can be related based on their likelihood—e.g., a student who is above mean in SAT has 63% likelihood of achieving an above-mean college GPA. Despite its increasing attention, the concept of PS is restricted to a simple bivariate scenario (X-Y pair, which hinders the development and application of PS in popular multivariate modeling such as structural equation modeling (SEM. Therefore, this study addresses an empirical-based simulation study that explores the potential of detecting PS-based relationship in SEM, called PS-SEM. The simulation results showed that the proposed PS-SEM method can detect and identify PS-based when data follow PS-based relationships, thereby providing a useful method for researchers to explore PS-based SEM in their studies. Conclusions, implications, and future directions based on the findings are also discussed.

Intron-exon organization of the active human protein S gene PS. alpha. and its pseudogene PS. beta. : Duplication and silencing during primate evolution

Energy Technology Data Exchange (ETDEWEB)

Ploos van Amstel, H.; Reitsma, P.H.; van der Logt, C.P.; Bertina, R.M. (University Hospital, Leiden (Netherlands))

1990-08-28

The human protein S locus on chromosome 3 consists of two protein S genes, PS{alpha} and PS{beta}. Here the authors report the cloning and characterization of both genes. Fifteen exons of the PS{alpha} gene were identified that together code for protein S mRNA as derived from the reported protein S cDNAs. Analysis by primer extension of liver protein S mRNA, however, reveals the presence of two mRNA forms that differ in the length of their 5{prime}-noncoding region. Both transcripts contain a 5{prime}-noncoding region longer than found in the protein S cDNAs. The two products may arise from alternative splicing of an additional intron in this region or from the usage of two start sites for transcription. The intron-exon organization of the PS{alpha} gene fully supports the hypothesis that the protein S gene is the product of an evolutional assembling process in which gene modules coding for structural/functional protein units also found in other coagulation proteins have been put upstream of the ancestral gene of a steroid hormone binding protein. The PS{beta} gene is identified as a pseudogene. It contains a large variety of detrimental aberrations, viz., the absence of exon I, a splice site mutation, three stop codons, and a frame shift mutation. Overall the two genes PS{alpha} and PS{beta} show between their exonic sequences 96.5% homology. Southern analysis of primate DNA showed that the duplication of the ancestral protein S gene has occurred after the branching of the orangutan from the African apes. A nonsense mutation that is present in the pseudogene of man also could be identified in one of the two protein S genes of both chimpanzee and gorilla. This implicates that silencing of one of the two protein S genes must have taken place before the divergence of the three African apes.

3-D analysis of eddy current in permanent magnet of interior permanent magnet motors

International Nuclear Information System (INIS)

Kawase, Yoshihiro; Yamaguchi, Tadashi; Fukanaga, Hiromu; Ito, Shokichi

2002-01-01

Interior permanent magnet motors are widely used in various fields. However, in high-speed operations, it is important to decrease the eddy current loss in the permanent magnet. In order to decrease the eddy current loss, we propose to divide the permanent magnet. In this paper, we clarified the effect of division of permanent magnet on the eddy current loss using the 3-D finite element method. (Author)

Evaluation of Recycling Polystyrene (PS) from a Microbiology Product

OpenAIRE

Eklöf, Jonas

2014-01-01

Detta är ett beställningsarbete av Plastone Oy och i det undersöks möjligheterna vad man kan göra genom återvinning med avfallsmaterialet som uppstår då man tillverkar en mikrobiologisk produkt i deras plastfabrik. Produkten tillverkas genom formsprutning och materialet som används är polystyren (PS). Ur litteraturstudien fann man varierande möjligheter på hur man kan återvinna PS på bästa sätt, men ingen lösning som har varit effektiv i praktiken. Det framgick också att återvunnet PS inte är...

Motor-Generator powering the PS (Proton Synchrotron) main magnets

CERN Multimedia

1983-01-01

This motor-generator,30 MW peak, 1500 r.p.m.,pulsed power supply for the PS main magnet replaced in 1968 the initial 3000 r.p.m. motor-generator-flywheel set which had served from the PS start-up in 1959 until end 1967. See also photo 8302337 and its abstract.

The surface properties of PS/PMMA blends nanostructured polymeric layers

International Nuclear Information System (INIS)

Prosycevas, I.; Tamulevicius, S.; Guobiene, A.

2004-01-01

Solvent cast thin films of blends polystyrene (PS) and poly (methylmethacrylate) (PMMA) with nominal compositions ranging from 25/75 wt.%/v% (w/v) up to 75/25 w/v PS/PMMA with toluene as the mutual solvent on crystalline Si (100) and silica substrates has been studied. Films of PS and PMMA blends have been examined by atomic force microscopy (AFM) and ellipsometry. The blend films with less than 50% PMMA bulk concentration generally exhibit pitted surfaces; the pit size varies with film thickness and bulk composition. When the PMMA bulk concentration is greater than 50%, the film surface can be described as island-like phase-separated structure. The surface segregation and morphology are explained in terms of solubility of the two polymers in the solvent and rewetting of PMMA relative to PS

Comparison of torque capability of three-phase permanent magnet synchronous motors with different permanent magnet arrangement

International Nuclear Information System (INIS)

Stumberger, Bojan; Stumberger, Gorazd; Hadziselimovic, Miralem; Hamler, Anton; Gorican, Viktor; Jesenik, Marko; Trlep, Mladen

2007-01-01

The paper presents a comparison of torque capability of three-phase permanent magnet synchronous motors with different permanent magnet arrangement. Motors with the following permanent magnet topologies were accounted for in the comparison: the surface-mounted permanent magnet synchronous motor (SMPMSM), the interior permanent magnet synchronous motor (IPMSM), the permanent magnet-assisted synchronous reluctance motor (PMASRM) and the flux reversal permanent magnet motor (FRPMM). Finite element method analysis is employed to determine the performance of each motor. Calculated performance of four-pole IPMSM determined by finite element method calculation is confirmed with the measurements at nearly constant nominal output power in the range of speed 3000-10,000 rpm

Effectiveness of early adalimumab therapy in psoriatic arthritis patients from Reuma.pt - EARLY PsA.

Science.gov (United States)

Santos, Helena; Eusébio, Mónica; Borges, Joana; Gonçalves, Diana; Ávila-Ribeiro, Pedro; Faria, Daniela Santos; Lopes, Carina; Rovisco, João; Águeda, Ana; Nero, Patrícia; Valente, Paula; Cravo, Ana Rita; Santos, Maria José

2017-01-01

Objective To compare outcomes in psoriatic arthritis (PsA) patients initiating adalimumab (ADA), with short- and long-term disease duration and to evaluate the potential effect of concomitant conventional synthetic disease-modifying antirheumatic drugs (csDMARD) or glucocorticoids. Methods Analyses included adult PsA patients registered in the Rheumatic Diseases Portuguese Register (Reuma.pt) between June 2008-June 2016 who received ADA for ≥3 months. Psoriatic Arthritis Response Criteria (PsARC) response, tender and swollen joint count, inflammatory parameters, patient (PtGA) and physician global assessment (PhGA), Disease Activity Score-28 joints (DAS28), and Health Assessment Questionnaire Disability Index (HAQ-DI) were compared between patients with PsA) and those with ≥5 years of disease duration (late PsA). Time to achieving PsARC response was estimated using the Kaplan-Meier method. Results Of 135 PsA patients treated with ADA, 126 had information on disease duration (earlyPsA, n=41). PsARC response was achieved by 72.9% of the patients (88.0% early PsA vs 62.2% late PsA; P=0.022) after 3 months and by 85.4% after 24 months (100% early PsA vs 75.9% late PsA; P=0.044). Early PsA patients achieved significantly less painful joints (2.7 vs 6.7, p=0.006), lower mean C-reactive protein (0.5 mg/dL vs 1.3 mg/dL; P=0.011), and PhGA (18.3 vs 28.1; P=0.020) at 3 months. In the long term, early PsA patients also had fewer swollen joints (0.3 vs 1.7; P=0.030) and lower PhGA (6.3 vs 21.9; PPsA, respectively. Early PsA patients obtained PsARC response more rapidly than late PsA (3.8 and 7.4 months, respectively; P=0.008). Concomitant csDMARDs showed clinical benefit (2-year PsARC response, 88.3% vs 60.0%; P=0.044). Concomitant glucocorticoids had no effect on PsARC response over 2 years of follow-up. Persistence on ADA was similar in both groups. Conclusion Early PsA patients had a greater chance of improvement after ADA therapy and better functional outcome, and

Complementary low energy ion scattering and X-ray photoelectron spectroscopy characterization of polystyrene submitted to N{sub 2}/H{sub 2} glow discharge

Energy Technology Data Exchange (ETDEWEB)

Bonatto, F., E-mail: bonatto02@yahoo.com.br [Instituto de Fisica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 91509-900 (Brazil); Rovani, S. [Universidade de Caxias do Sul, Caxias do Sul, Rio Grande do Sul 95070-560 (Brazil); Kaufmann, I.R.; Soares, G.V. [Instituto de Fisica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 91509-900 (Brazil); Baumvol, I.J.R. [Instituto de Fisica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 91509-900 (Brazil); Universidade de Caxias do Sul, Caxias do Sul, Rio Grande do Sul 95070-560 (Brazil); Krug, C. [Instituto de Fisica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 91509-900 (Brazil)

2012-02-15

Low energy ion scattering (LEIS) and X-ray photoelectron spectroscopy (XPS) were used to access the elemental composition and chemical bonding characteristics of polystyrene (PS) surfaces sequentially treated by corona and glow discharge (plasma) processing in N{sub 2}/H{sub 2} ambient. The latter has shown activity as suppressor of pathogenic Staphylococcus epidermidis biofilms. LEIS indicated that oxygen from the corona discharge process is progressively replaced by nitrogen at the PS surface. XPS shows C=N and N-C=O chemical groups as significant inhibitors of bacterial adhesion, suggesting application in medical devices.

Thomson scattering measurements from asymmetric interpenetrating plasma flows

Energy Technology Data Exchange (ETDEWEB)

Ross, J. S., E-mail: ross36@llnl.gov; Moody, J. D.; Fiuza, F.; Ryutov, D.; Divol, L.; Huntington, C. M.; Park, H.-S. [Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, California 94551 (United States)

2014-11-15

Imaging Thomson scattering measurements of collective ion-acoustic fluctuations have been utilized to determine ion temperature and density from laser produced counter-streaming asymmetric flows. Two foils are heated with 8 laser beams each, 500 J per beam, at the Omega Laser facility. Measurements are made 4 mm from the foil surface using a 60 J 2ω probe laser with a 200 ps pulse length. Measuring the electron density and temperature from the electron-plasma fluctuations constrains the fit of the multi-ion species, asymmetric flows theoretical form factor for the ion feature such that the ion temperatures, ion densities, and flow velocities for each plasma flow are determined.

CoPs Facing Rationalization: The Politics of Community Reproduction

Science.gov (United States)

Kilskar, Stine Skaufel; Ingvaldsen, Jonas A.; Valle, Nina

2018-01-01

Purpose: This paper aims to explore the relationship between the contemporary forms of manufacturing rationalization and the reproduction of communities of practice (CoPs) centred on tasks and craft. Building on critical literature highlighting the tensions between CoPs and rationalization, this paper aims to develop a nuanced account of how CoPs…

Permanent quadrupole magnets

International Nuclear Information System (INIS)

Bush, E.D. Jr.

1976-01-01

A family of quadrupole magnets using a soft iron return yoke and circular cross-section permanent magnet poles were fabricated to investigate the feasibility for use in ion or electron beam focusing applications in accelerators and transport lines. Magnetic field measurements yielded promising results. In fixed-field applications, permanent magnets with sufficient gradients would be a low cost substitute for conventional electromagnets, eliminating the need for power supplies, associated wiring, and cooling. Based on preliminary tests, it was seen that permanent quadrupole magnets can offer a low cost, reliable solution in applications requiring small, fixed-field focusing devices for use in ion or electron-beam transport systems. Permanent magnets do require special considerations in design, fabrication, handling, and service that are different than encountered in conventional quadrupole magnets. If these basic conditions are satisfied, the resulting beam-focusing device would be stable, maintenance free, with virtually an indefinite lifetime

Antiphosphatidylserine/prothrombin antibodies (aPS/PT) as potential markers of antiphospholipid syndrome.

Science.gov (United States)

Vlagea, Alexandru; Gil, Antonio; Cuesta, Maria V; Arribas, Florencia; Diez, Jesús; Lavilla, Paz; Pascual-Salcedo, Dora

2013-06-01

The antiphospholipid antibodies present in antiphospholipid syndrome (APS) are directed at a number of phospholipid-binding proteins: β2 glycoprotein I (β2GPI), prothrombin, and so on. Antibodies directed at β2GPI are accepted as a classification criterion for APS, while the presence of antiprothrombin antibodies is not. In the present article, we investigated the possible role of antiphosphatidylserine/prothrombin antibodies (aPS/PT) as marker of APS on a cohort of 295 individuals with APS (95 primary APS and 45 secondary APS) and APS-related diseases. We found aPS/PT to be highly associated with venous thrombosis (immunoglobulin G [IgG] aPS/PT odds ratio [OR], 7.44; 95% confidence interval [CI], 3.97-13.92 and IgM aPS/PT OR, 2.54; 95% CI, 1.35-4.77) and obstetric abnormalities (IgG aPS/PT OR, 2.37; 95% CI, 1.04-5.43), but not with arterial thrombosis. A very high degree of concordance between the concentration of aPS/PT and lupus anticoagulant activity was demonstrated. Therefore, we support the inclusion of aPS/PT determination as second-level assay to confirm APS classification.

Analysis of Land Deformation on Slope Area using PS InSAR. Case Study: Malang Area

International Nuclear Information System (INIS)

Sudiana, Dodi; Rizkinia, Mia; Arief, Rahmat; Rokhmatuloh; Ardiansyah; Setiadi, Bambang; Bayuaji, Luhur; Sri Sumantyo, Josaphat Tetuko

2014-01-01

The geographical position of Indonesia located between two continents and oceans is strategic, but at large risk of experiencing various disasters. Climate change and vulnerable location (surrounded by plates and geological faults in the Earth's crust) creates an earthquake-prone region and causes land/mudslides. In this paper, PS InSAR method (Persistent Scatterer Interferometric Synthetic Aperture Radar) is implemented to Phased Array type L-band Synthetic Aperture Radar (PALSAR) data to study the potential damage caused by the earthquake or volcanic eruption in Malang vicinity. By comparing the amplitude images periodically, shifting soil can be determined using precise orbital information. The analysis showed a significant decrease of land deformation on slope area in Klojen district in Malang city, reached up to −7.128 mm/year

Enhanced personal protection system for the PS

CERN Multimedia

Caroline Duc

2013-01-01

During the first long shutdown (LS1) a new safety system will be installed in the primary beam areas of the PS complex in order to bring the standard of personnel radiation protection at the PS into line with that of the LHC.   Pierre Ninin, deputy group leader of GS-ASE and responsible for the installation of the new PS complex safety system, in front of a new access control system. The LHC access control systems are state-of-the-art, whereas those of the injection chain accelerators were running the risk of becoming obsolete. For the past two years a project to upgrade the access and safety systems of the first links in the LHC accelerator chain has been underway to bring them into compliance with nuclear safety standards. These systems provide the personnel with automatic protection by limiting access to hazardous areas and by ensuring that nobody is present in the areas when the accelerator is in operation. By the end of 2013, the project teams will ha...

Beyond the Point Ps Approximation

OpenAIRE

Stepanov, Sergey V.; Zvezhinskiy, Dmitry S.; Byakov, Vsevolod M.

2012-01-01

In application to positron annihilation spectroscopy, Ps atom is considered not as a point particle, but as a finite size e+ e- pair localized in a bubble-state in a medium. Variation of the internal Coulombic e+ -e- attraction vs. the bubble radius is estimated.

RF Scenarios for Pb54+ Ions in the PS2

CERN Document Server

Benedikt, M; Hancock, S; CERN. Geneva. AB Department

2008-01-01

This note analyses some of the rf scenarios that are presently being considered for lead ions in the PS2. An earlier note principally concerning protons [1] highlighted the problem of the large revolution frequency swing of ions in the PS2 and the issue of bunching factor with direct injection from the LEIR machine. We present solutions based on additional rf systems in LEIR and consider the 40 MHz principal rf system proposed for the PS2 in the earlier work to have switchable tuning ranges to cover the large frequency swing required.

Positronium collisions with atoms and molecules

Science.gov (United States)

Fabrikant, I. I.; Gribakin, G. F.; Wilde, R. S.

2017-11-01

We review recent theoretical efforts to explain observed similarities between electron-atom and positronium(Ps)-atom scattering which also extends to molecular targets. In the range of the projectile velocities above the threshold for Ps ionization (break-up) this similarity can be explained in terms of quasi-free electron scattering and impulse approximation. However, for lower Ps velocities more sophisticated methods should be developed. Our calculations of Ps scattering by heavy noble-gas atoms agree well with experiments at Ps velocities above the Ps ionization threshold. However, in contrast to electron scattering cross sections, at lower velocities they exhibit maxima whereas the experimental cross sections tend to decrease toward lower velocities indicating the same similarity with electron scattering cross section observed above the threshold. Our preliminary results for Ps-N2 scattering confirm experimental observation of a resonance similar to the ∏ g resonance in electron-N2 scattering.

A&T Sector Note on the PS transverse feedback

CERN Document Server

Coly, Marcel; Blas, Alfred; Sterbini, Guido; CERN. Geneva. ATS Department

2017-01-01

In a particle accelerator, several contributions can degrade the beam quality and particularly the beam transverse emittance. In this document we will describe a system used in the CERN Proton Synchrotron (PS) to cope with the injection steering errors and the transverse instabilities: the PS transverse feedback (PS TFB). As time progresses, this system is also being used for other purpose, to increase in a controlled way the beam transverse emittance and to excite the beam for the Multi-Turn-Extraction (MTE). In 2016, it has been successfully used on some operational beams to damp injection oscillations. This allowed to test the reliability of the system for its operational deployment. A piquet service is available in case of problem.

Role of trapped and solvated electrons in Ps formation

International Nuclear Information System (INIS)

Stepanov, S.V.; Byakov, V.M.; Mikhin, K.V.; He, C.; Hirade, T.

2005-01-01

Role of trapped and solvated electrons in Ps formation is discussed. Combination of thermalized positron with such electrons is possible from the view point of the energy balance and may results in Ps formation. This process proceeds during all e = lifetime matter. Fitting of raw experimental e + -e - annihilation spectra has to be based on an adequate physical input, which often leads to necessity of nonexponential deconvolution of the spectra. We have interpreted the Ps formation data in polyethylene, ethylene-methylmethacrylate and polymethylmethacrylate in dark and in light vs. tome of the measurement and temperature. parameters characterized accumulation of trapped electrons and their recombination with counter ions and positrons are obtained. (author)

200 ps FWHM and 100 MHz repetition rate ultrafast gated camera for optical medical functional imaging

Science.gov (United States)

Uhring, Wilfried; Poulet, Patrick; Hanselmann, Walter; Glazenborg, René; Zint, Virginie; Nouizi, Farouk; Dubois, Benoit; Hirschi, Werner

2012-04-01

The paper describes the realization of a complete optical imaging device to clinical applications like brain functional imaging by time-resolved, spectroscopic diffuse optical tomography. The entire instrument is assembled in a unique setup that includes a light source, an ultrafast time-gated intensified camera and all the electronic control units. The light source is composed of four near infrared laser diodes driven by a nanosecond electrical pulse generator working in a sequential mode at a repetition rate of 100 MHz. The resulting light pulses, at four wavelengths, are less than 80 ps FWHM. They are injected in a four-furcated optical fiber ended with a frontal light distributor to obtain a uniform illumination spot directed towards the head of the patient. Photons back-scattered by the subject are detected by the intensified CCD camera; there are resolved according to their time of flight inside the head. The very core of the intensified camera system is the image intensifier tube and its associated electrical pulse generator. The ultrafast generator produces 50 V pulses, at a repetition rate of 100 MHz and a width corresponding to the 200 ps requested gate. The photocathode and the Micro-Channel-Plate of the intensifier have been specially designed to enhance the electromagnetic wave propagation and reduce the power loss and heat that are prejudicial to the quality of the image. The whole instrumentation system is controlled by an FPGA based module. The timing of the light pulses and the photocathode gating is precisely adjustable with a step of 9 ps. All the acquisition parameters are configurable via software through an USB plug and the image data are transferred to a PC via an Ethernet link. The compactness of the device makes it a perfect device for bedside clinical applications.

Clinical and Patient-reported Outcomes in Patients with Psoriatic Arthritis (PsA) by Body Surface Area Affected by Psoriasis: Results from the Corrona PsA/Spondyloarthritis Registry.

Science.gov (United States)

Mease, Philip J; Karki, Chitra; Palmer, Jacqueline B; Etzel, Carol J; Kavanaugh, Arthur; Ritchlin, Christopher T; Malley, Wendi; Herrera, Vivian; Tran, Melody; Greenberg, Jeffrey D

2017-08-01

Psoriatic arthritis (PsA) is commonly comorbid with psoriasis; the extent of skin lesions is a major contributor to psoriatic disease severity/burden. We evaluated whether extent of skin involvement with psoriasis [body surface area (BSA) > 3% vs ≤ 3%] affects overall clinical and patient-reported outcomes (PRO) in patients with PsA. Using the Corrona PsA/Spondyloarthritis Registry, patient characteristics, disease activity, and PRO at registry enrollment were assessed for patients with PsA aged ≥ 18 years with BSA > 3% versus ≤ 3%. Regression models were used to evaluate associations of BSA level with outcome [modified minimal disease activity (MDA), Health Assessment Questionnaire (HAQ) score, patient-reported pain and fatigue, and the Work Productivity and Activity Impairment questionnaire score]. Adjustments were made for age, sex, race, body mass index, disease duration, and history of biologics, disease-modifying antirheumatic drug, and prednisone use. This analysis included 1240 patients with PsA with known BSA level (n = 451, BSA > 3%; n = 789, BSA ≤ 3%). After adjusting for potential confounding variables, patients with BSA > 3% versus ≤ 3% had greater patient-reported pain and fatigue and higher HAQ scores (p = 2.33 × 10 -8 , p = 0.002, and p = 1.21 × 10 -7 , respectively), were 1.7× more likely not to be in modified MDA (95% CI 1.21-2.41, p = 0.002), and were 2.1× more likely to have overall work impairment (1.37-3.21, p = 0.0001). These Corrona Registry data show that substantial skin involvement (BSA > 3%) is associated with greater PsA disease burden, underscoring the importance of assessing and effectively managing psoriasis in patients with PsA because this may be a contributing factor in PsA severity.

Improving surface-enhanced Raman scattering effect using gold-coated hierarchical polystyrene bead substrates modified with postgrowth microwave treatment.

Science.gov (United States)

Yuen, Clement; Zheng, Wei; Huang, Zhiwei

2008-01-01

We report a novel postgrowth microwave heating implementation by selectively modifying hierarchical polystyrene (PS) bead substrates coated with gold (Au) films to effectively improve the surface-enhanced Raman scattering (SERS) effect on the analytes. The SERS signal of probe molecule rhodamine 6G (Rh 6G) on the microwave-treated Au-PS substrates can be improved by 10-fold, while the detection limit of Rh 6G in concentration can be enhanced by two orders of magnitude compared to the as-growth substrates. The high-quality SERS spectrum of saliva can also be acquired using the modified substrates, demonstrating the potential for the realization of the high-performance SERS substrates for biomedical applications.

Jagiellonian University Advances in Ps Manipulations and Laser Studies in the AEgIS Experiment

CERN Document Server

Caravita, R; Amsler, C; Bonomi, G; Brusa, R S; Caccia, M; Castelli, F; Cerchiari, G; Comparat, D; Consolati, G; Demetrio, A; Di Noto, L; Doser, M; Evans, C; Ferragut, R; Fesel, J; Fontana, A; Gerber, S; Giammarchi, M; Gligorova, A; Guatieri, F; Haider, S; Hinterberger, A; Holmestad, H; Kellerbauer, A; Khalidova, O; Krasnický, D; Lagomarsino, V; Lansonneur, P; Lebrun, P; Malbrunot, C; Mariazzi, S; Marton, J; Matveev, V; Mazzotta, Z; Müller, S R; Nebbia, G; Nedelec, P; Oberthaler, M; Pacifico, N; Pagano, D; Penasa, L; Petracek, V; Prelz, F; Prevedelli, M; Ravelli, L; Rienäcker, B; Robert, J; Røhne, O M; Rotondi, A; Sandaker, H; Santoro, R; Smestad, L; Sorrentino, F; Testera, G; Tietje, I; Widmann, E; Yzombard, P; Zimmer, C; Zmeskal, J; Zurlo, N

2017-01-01

Positronium (Ps), the unstable bound state of electron and positron, is a valuable system for neutral antimatter spectroscopic studies and for antihydrogen production. Forming a pulsed beam cold antihydrogen using charge-exchange with the Rydberg Ps is the goal of the AEgIS Collaboration, which aims to measure gravity on neutral antimatter. Recent results achieved in producing, manipulating and studying Ps are summarized. Ps has been first produced with mesoporous silica targets in a reflection geometry. Spectroscopy of Ps n = 3 state has been conducted, yielding as a byproduct an independent estimate of the produced Ps temperature. Efficient laser excitation to the Rydberg levels was then achieved, validating the proof-of-concept of AEgIS. Subsequently, production of Ps from a new class of transmission targets was also achieved, opening the possibility for future experiments.

DiPS: A Unifying Approach for developing System Software

OpenAIRE

Michiels, Sam; Matthijs, Frank; Walravens, Dirk; Verbaeten, Pierre

2002-01-01

In this paper we unify three essential features for flexible system software: a component oriented approach, self-adaptation and separation of concerns.We propose DiPS (Distrinet Protocol Stack), a component framework, which offers components, an anonymous interaction model and connectors to handle non-functional aspects such as concurrency. DiPS has effectively been used in industrial protocol stacks and device drivers.

Modelling of Ne-like copper X-ray laser driven by 1.2 ps short pulse and 280 ps background pulse configuration

International Nuclear Information System (INIS)

Demir, A.; Kenar, N.; Goktas, H.; Tallents, G.J.

2004-01-01

Detailed simulations of Ne-like Cu x-ray laser are undertaken using the EHYBRID code. The atomic physics data are obtained using the Cowan code. The optimization calculations are performed in terms of the intensity of background and the time separation between the background and the short pulse. The optimum value is obtained for the conditions of a Nd:glass laser with 1.2 ps pulse at 4.4 x 10 15 W cm -2 irradiance pumping a plasma pre-formed by a 280 ps duration pulse at 5.4 x 10 12 W cm -2 with peak-to-peak pulse separation set at 300 ps. X-ray resonance lines between 6 A and 15 A emitted from copper plasmas have been simulated. Free-free and free-bound emission from the Si-, Al-, Mg-, Na-, Ne- and F-like ions is calculated in the simulation. (author)

Framing-camera tube developed for sub-100-ps range

International Nuclear Information System (INIS)

Anon.

1978-01-01

A new framing-camera tube, developed by Electronics Engineering, is capable of recording two-dimensional image frames with high spatial resolution in the sub-100-ps range. Framing is performed by streaking a two-dimensional electron image across narrow slits; the resulting electron-line images from the slits are restored into a framed image by a restorer deflector operating synchronously with the dissector deflector. We have demonstrated its performance in a prototype tube by recording 125-ps-duration framed images of 2.5-mm patterns. The limitation in the framing speed is in the external electronic drivers for the deflectors and not in the tube design characteristics. Shorter frame durations (below 100 ps) can be obtained by use of faster deflection drivers

Electrophysical properties of PMN-PT-PS-PFN:Li ceramics

Directory of Open Access Journals (Sweden)

R. Skulski

2013-01-01

Full Text Available We present the technology of obtaining and the electrophysical properties of a multicomponent material 0.61PMN-0.20PT-0.09PS-0.1PFN:Li (PMN-PT-PS-PFN:Li. The addition of PFN into PMN-PT decreases the temperature of final sintering which is very important during technological process (addition of Li decreases electric conductivity of PFN. Addition of PS i.e., PbSnO3 (which is unstable in ceramic form permits to shift the temperature of the maximum of dielectric permittivity. One-step method of obtaining ceramic samples from oxides and carbonates has been used. XRD, microstructure, scanning calorimetry measurements and the main dielectric, ferroelectric and electromechanical properties have been investigated for the obtained samples.

SAFETY: STRICTER CONTROLS IN CONTROLLED AREAS IN THE PS

CERN Multimedia

G. Daems

2001-01-01

The PS accelerators will soon stop for several months. Work will take place in controlled areas in the PS and will involve many people who are not always aware of the risks associated with the work sites. To guarentee the safety of these workers, the following two measures will be applied: everyone working in a controlled zone - Linacs, PSB, and PS machines tunnels, and transfer lines - must wear, visibly, his CERN access card and his film badge. the CERN access card and the film badge will only be issued after following a basic safety course. Regular checks will be carried out during the shutdown. Anyone without these two items on their person will be obliged to leave the area immediately.

The four Ps of marketing mix in Information Science literature

OpenAIRE

Amaral, Sueli Angelica Do

2000-01-01

Analisa 60 documentos sobre os 4Ps do composto de marketing cm unidades de informação da literatura de Ciência da Informação no período de 1975 a 1995, para conhecer quantos e quais autores escreveram sobre o tema, qual o pioneiro, quem foi o pioneiro a propor adição de Ps. Apresenta a cronologia dos documentos estudados e discute as 4Ps do composto de marketing. Propõe a adoção da mais completa proposta analisada como forma de garantir o futuro das unidades de informação. ___________________...

Beam Diagnostics for Laser Undulator Based on Compton Backward Scattering

CERN Document Server

Kuroda, R

2005-01-01

A compact soft X-ray source is required in various research fields such as material and biological science. The laser undulator based on Compton backward scattering has been developed as a compact soft X-ray source for the biological observation at Waseda University. It is performed in a water window region (250eV - 500 eV) using the interaction between 1047 nm Nd:YLF laser (10ps FWHM) and about 5 MeV high quality electron beam (10ps FWHM) generated from rf gun system. The range of X-ray energy in the water window region has K-shell absorption edges of Oxygen, Carbon and Nitrogen, which mainly constitute of living body. Since the absorption coefficient of water is much smaller than the protein's coefficient in this range, a dehydration of the specimens is not necessary. To generate the soft X-ray pulse stably, the electron beam diagnostics have been developed such as the emittance measurement using double slit scan technique, the bunch length measurement using two frequency analysis technique. In this confere...

HiPS - Hierarchical Progressive Survey Version 1.0

Science.gov (United States)

Fernique, Pierre; Allen, Mark; Boch, Thomas; Donaldson, Tom; Durand, Daniel; Ebisawa, Ken; Michel, Laurent; Salgado, Jesus; Stoehr, Felix; Fernique, Pierre

2017-05-01

This document presents HiPS, a hierarchical scheme for the description, storage and access of sky survey data. The system is based on hierarchical tiling of sky regions at finer and finer spatial resolution which facilitates a progressive view of a survey, and supports multi-resolution zooming and panning. HiPS uses the HEALPix tessellation of the sky as the basis for the scheme and is implemented as a simple file structure with a direct indexing scheme that leads to practical implementations.

Estimation of small surface displacements in the Upper Rhine Graben area from a combined analysis of PS-InSAR, levelling and GNSS data

Science.gov (United States)

Fuhrmann, T.; Caro Cuenca, M.; Knöpfler, A.; van Leijen, F. J.; Mayer, M.; Westerhaus, M.; Hanssen, R. F.; Heck, B.

2015-10-01

The intra-plate deformation of the Upper Rhine Graben (URG) located in Central Europe is investigated using geodetic measurement techniques. We present a new approach to calculate a combined velocity field from InSAR, levelling and GNSS measurements. As the expected tectonic movements in the URG area are small (less than 1 mm a-1), the best possible solutions for linear velocity rates from single-technique analyses are estimated in a first step. Second, we combine the velocity rates obtained from InSAR (line of sight velocity rates in ascending and descending image geometries), levelling (vertical velocity rates) and GNSS (horizontal velocity rates) using least-squares adjustment (LSA). Focusing on the Northern URG area, we analyse SAR data on four different image stacks (ERS ascending, ERS descending, Envisat ascending, Envisat descending) using the Persistent Scatterer (PS) approach. The linear velocity rates in ascending and descending image geometries, respectively, are estimated in an LSA from joint time-series analysis of ERS and Envisat data. Vertical velocity rates from levelling are obtained from a consistent adjustment of more than 40 000 measured height differences using a kinematic displacement model. Horizontal velocity rates in east and north direction are calculated from a time-series analysis of daily coordinate estimates at 76 permanently operating GNSS sites in the URG region. As the locations, at which the measurement data of PS-InSAR, levelling and GNSS reside, do not coincide, spatial interpolation is needed during several steps of the rigorous processing. We use Ordinary Kriging to interpolate from a given set of data points to the locations of interest with a special focus on the modeling and propagation of errors. The final 3-D velocity field is calculated at a 200 m grid, which carries values only close to the location of PS points, resulting in a mean horizontal and vertical precision of 0.30 and 0.13 mm a-1, respectively. The vertical

Physics with primary beams of the KEK-PS

International Nuclear Information System (INIS)

Tanaka, Kazuhiro; Yoshii, Masahito

1993-08-01

The 12-GeV Proton Synchrotron (PS) at the National Laboratory for High Energy Physics (KEK) has provided great opportunities to high-energy-physics and related communities as a unique high-energy hadron machine, since its operation in 1976. Activities of the KEK-PS are indispensable for the rapid development in the field. Six experimental subjects are proposed in this Report; (1) media effects in φ meson decay, (2) multifragmentation in high-energy reactions, (3) mechanism of high-energy reactions by means of radio-chemical methods, (4) physics with polarized high-energy neutrons, (5) physics with polarized high-energy deuterons, and (6) hypernucleus with high-energy heavy-ion beams. As a summary, new facilities (a new injector, a new beamline and a new experimental area) and physics programs with primary beams, proposed in this Report are themselves unique and valuable. Moreover, technical developments and physics outcomes stimulated with those new facilities are indispensable for future plans of the KEK-PS. (J.P.N.)

Facile Synthesis of Mono-Dispersed Polystyrene (PS/Ag Composite Microspheres via Modified Chemical Reduction

Directory of Open Access Journals (Sweden)

Wen Zhu

2013-12-01

Full Text Available A modified method based on in situ chemical reduction was developed to prepare mono-dispersed polystyrene/silver (PS/Ag composite microspheres. In this approach; mono-dispersed PS microspheres were synthesized through dispersion polymerization using poly-vinylpyrrolidone (PVP as a dispersant at first. Then, poly-dopamine (PDA was fabricated to functionally modify the surfaces of PS microspheres. With the addition of [Ag(NH32]+ to the PS dispersion, [Ag(NH32]+ complex ions were absorbed and reduced to silver nanoparticles on the surfaces of PS-PDA microspheres to form PS/Ag composite microspheres. PVP acted both as a solvent of the metallic precursor and as a reducing agent. PDA also acted both as a chemical protocol to immobilize the silver nanoparticles at the PS surface and as a reducing agent. Therefore, no additional reducing agents were needed. The resulting composite microspheres were characterized by TEM, field emission scanning electron microscopy (FESEM, energy-dispersive X-ray spectroscopy (EDS, XRD, UV-Vis and surface-enhanced Raman spectroscopy (SERS. The results showed that Ag nanoparticles (NPs were homogeneously immobilized onto the PS microspheres’ surface in the presence of PDA and PVP. PS/Ag composite microspheres were well formed with a uniform and compact shell layer and were adjustable in terms of their optical property.

Observing shape resonances in ultraslow H^++H elastic scattering

Science.gov (United States)

Macek, J. H.; Schultz, D. R.; Ovchinnikov, S. Yu.; Krstic, P. S.

2004-05-01

We have calculated highly accurate elastic and charge transfer cross sections for proton-hydrogen scattering at energies 0.0001-10 eV, using fully quantal approach (P.S. Krstic and D.R. Schultz, J. Phys. B 32, 3485 (1999)). A number of resonances are observed. We calculate the positions and widths of the shape resonances in the effective potentials for various orbital angular momenta (J. H. Macek and S. Yu. Ovchinnikov, Phys. Rev. A 50, 468 (1994)). These correlate well with the observed resonances. We acknowledge support from the US DOE through ORNL, managed by UT-Battelle, LLC under contract DE-AC05-00OR22725.

Kultuur isiksuse psühholoogiat ei mõjuta / Tiit Kändler

Index Scriptorium Estoniae

Kändler, Tiit, 1948-

2010-01-01

Psühholoogia uuemate andmete kohaselt ei sõltu indiviidi seadumus kultuurist, soost, vanusest, haridusest. Eesti psühholoogide Jüri Alliku ja Ann Realo osalusel ajakirjas "Journal Personality and Social Psychology" ilmunud artiklist

Kultuur isiksuse psühholoogiat ei mõjuta / Tiit Kändler

Index Scriptorium Estoniae

Kändler, Tiit, 1948-

2005-01-01

Psühholoogia uuemate andmete kohaselt ei sõltu indiviidi seadumus kultuurist, soost, vanusest, haridusest. Eesti psühholoogide Jüri Alliku ja Anu Realo osalusel ajakirjas "Journal Personality and Social Psychology" ilmunud artiklist

TU-F-CAMPUS-T-02: Risk Assessment of Scattered Neutrons for a Fetus From Proton Therapy of a Brain Tumor During Pregnancy

Energy Technology Data Exchange (ETDEWEB)

Geng, C [Massachusetts General Hospotal and Harvard Medical School, Boston, MA (United States); Nanjing University of Aeronautics and Astronautics, Nanjing (China); Moteabbed, M; Paganetti, H [Massachusetts General Hospotal and Harvard Medical School, Boston, MA (United States); Xu, X [Rensselaer Polytechnic Inst., Troy, NY (United States)

2015-06-15

Purpose: To determine the scattered neutron dose and the resulting risk for a fetus from proton therapy for brain tumors during pregnancy. Methods: Using the Monte Carlo platform TOPAS, the ICRP reference parameters based anthropomorphic pregnancy phantoms for three stages (3-, 6-, 9-month) were applied to evaluate the scattered neutron dose and dose equivalent. To calculate the dose equivalent, organ specific linear energy transfer (LET) based quality factor was used. Treatment plans from both passive scattering (PS) and pencil beam scanning (PBS) methods were considered in this study. Results: For pencil beam scanning, the neutron dose equivalent in the soft tissue of the fetus increases from 1.53x10−{sup 3} to 2.84x10−{sup 3} mSv per treatment Gy with increasing stage of gestation. This is due to scattered neutrons from the patient as the main contaminant source in PBS and a decrease in distance between the soft tissue of the fetus and GTV with increasing stage of gestation. For passive scattering, neutron dose equivalent to the soft tissue of the fetus shows a decrease from 0.17 to 0.13 mSv per treatment Gy in different stages, while the dose to the brain shows little difference around 0.18 mSv per treatment Gy because scattered neutrons from the treatment head contribute predominantly in passive scattering. Conclusion: The results show that the neutron dose to the fetus assuming a prescribed dose of 52.2 Gy is negligible for PBS, and is comparable to the scattered dose (0–10 mSv) from a head and neck CT scan for PS. It can be concluded that the dose to fetus is far lower than the thresholds of malformation, SMR and lethal death. The excess relative risk of childhood cancer induction would be increased by 0.48 and 0.103 using the Oxford Survey of Childhood Cancers and Japanese atomic model, respectively. Changran Geng is supported by the Chinese Scholarship Council (CSC) and the National Natural Science Foundation of China (Grant No. 11475087)

File list: His.PSC.10.AllAg.iPS_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available His.PSC.10.AllAg.iPS_cells hg19 Histone Pluripotent stem cell iPS cells SRX110016,S...315,SRX381309 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.10.AllAg.iPS_cells.bed ...

File list: His.PSC.05.AllAg.iPS_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available His.PSC.05.AllAg.iPS_cells hg19 Histone Pluripotent stem cell iPS cells SRX317576,S...077,SRX317607 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.05.AllAg.iPS_cells.bed ...

File list: Oth.PSC.05.AllAg.iPS_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available Oth.PSC.05.AllAg.iPS_cells mm9 TFs and others Pluripotent stem cell iPS cells SRX65...RX146524 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.AllAg.iPS_cells.bed ...

File list: His.PSC.20.AllAg.iPS_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available His.PSC.20.AllAg.iPS_cells hg19 Histone Pluripotent stem cell iPS cells SRX110015,S...315,SRX381309 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.20.AllAg.iPS_cells.bed ...

Comparison of molecular species of various transphosphatidylated phosphatidylserine (PS) with bovine cortex PS by mass spectrometry

NARCIS (Netherlands)

Chen, S.; Li, K.W.

2008-01-01

The exogenous introduction of a molecular species mixture of bovine cortex phosphatidylserine (BC-PS) has been claimed to improve memory function in subjects suffering from age-associated memory impairment and dementia. However, it has been also reported that oral administration of another molecular

Chemical resistance of core-shell particles (PS/PMMA) polymerized by seeded suspension

Energy Technology Data Exchange (ETDEWEB)

Ribeiro, Luiz Fernando Belchior; Machado, Ricardo Antonio Francisco, E-mail: ricardo.machado@ufsc.br [Universidade Federal de Santa Catarina (UFSC), Florianopolis, SC (Brazil). Departamento de Engenharia de Materiais; Gonçalves, Odinei Hess [Universidade Técnológica Federal do Paraná(UTFPR), Campo Mourão, PR (Brazil); Marangoni, Cintia [Universidade Federal de Santa Catarina (UFSC), Blumenau, SC (Brazil); Motz, Günter [Lehrstuhl Keramische Werkstoffe, Universität Bayreuth (Germany)

2017-07-01

Core-shell particles were produced on seeded suspension polymerization by using polystyrene (PS) as polymer core, or seed, and methyl methacrylate (MMA) as the shell forming monomer. Two synthesis routes were evaluated by varying the PS seed conversion before MMA addition. The main purpose of this work was to investigate the influence of synthesis routes on the morphology and chemical resistance of the resulting particles. {sup 1}H NMR spectroscopy showed that the use of PS seeds with lower conversion led to the formation of higher amount of poly(styrene-co-MMA). The copolymer acted as a compatibilizer, decreasing the interfacial energy between both homopolymers. As a consequence, a larger amount of reduced PMMA cluster were formed, as was revealed by TEM measurements. Samples in this system showed enhanced resistance to cyclohexane attack compared with pure PS, with a PS extraction of only 37% after 54 hours test. (author)

Chemical resistance of core-shell particles (PS/PMMA polymerized by seeded suspension

Directory of Open Access Journals (Sweden)

Luiz Fernando Belchior Ribeiro

2017-09-01

Full Text Available Abstract Core-shell particles were produced on seeded suspension polymerization by using polystyrene (PS as polymer core, or seed, and methyl methacrylate (MMA as the shell forming monomer. Two synthesis routes were evaluated by varying the PS seed conversion before MMA addition. The main purpose of this work was to investigate the influence of synthesis routes on the morphology and chemical resistance of the resulting particles. 1H NMR spectroscopy showed that the use of PS seeds with lower conversion led to the formation of higher amount of poly(styrene-co-MMA. The copolymer acted as a compatibilizer, decreasing the interfacial energy between both homopolymers. As a consequence, a larger amount of reduced PMMA cluster were formed, as was revealed by TEM measurements. Samples in this system showed enhanced resistance to cyclohexane attack compared with pure PS, with a PS extraction of only 37% after 54 hours test.

Femtosecond X-Ray Scattering Study of Ultrafast Photoinduced Structural Dynamics in Solvated [Co(terpy)2]2+

DEFF Research Database (Denmark)

Biasin, Elisa; Brandt van Driel, Tim; Kjær, Kasper Skov

2016-01-01

We study the structural dynamics of photoexcited [Co(terpy)2]2+ in an aqueous solution with ultrafast x-ray diffuse scattering experiments conducted at the Linac Coherent Light Source. Through direct comparisons with density functional theory calculations, our analysis shows that the photoexcitat......We study the structural dynamics of photoexcited [Co(terpy)2]2+ in an aqueous solution with ultrafast x-ray diffuse scattering experiments conducted at the Linac Coherent Light Source. Through direct comparisons with density functional theory calculations, our analysis shows...... find that the equilibrium bond-elongated structure of the high spin state is established on a single-picosecond time scale and that this state has a lifetime of ∼7 ps....

File list: ALL.PSC.50.AllAg.iPS_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available ALL.PSC.50.AllAg.iPS_cells mm9 All antigens Pluripotent stem cell iPS cells SRX9773...1,SRX035985,SRX1090869 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.50.AllAg.iPS_cells.bed ...

File list: ALL.PSC.50.AllAg.iPS_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available ALL.PSC.50.AllAg.iPS_cells hg19 All antigens Pluripotent stem cell iPS cells SRX088...16,SRX189400,SRX189399 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.PSC.50.AllAg.iPS_cells.bed ...

File list: ALL.PSC.20.AllAg.iPS_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available ALL.PSC.20.AllAg.iPS_cells hg19 All antigens Pluripotent stem cell iPS cells SRX088...27,SRX189400,SRX189399 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.PSC.20.AllAg.iPS_cells.bed ...

File list: ALL.PSC.20.AllAg.iPS_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available ALL.PSC.20.AllAg.iPS_cells mm9 All antigens Pluripotent stem cell iPS cells SRX9773...30,SRX146522,SRX146547 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.20.AllAg.iPS_cells.bed ...

File list: Pol.PSC.05.AllAg.iPS_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available Pol.PSC.05.AllAg.iPS_cells mm9 RNA polymerase Pluripotent stem cell iPS cells SRX97...7435,SRX027462,SRX977434 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Pol.PSC.05.AllAg.iPS_cells.bed ...

The PS complex as proton pre-injector for the LHC - design and implementation report

International Nuclear Information System (INIS)

Benedikt, M.; Blas, A.; Borburgh, J.

2000-01-01

The LHC will be supplied with protons from the pre-injector chain comprising Linac2, PS Booster and PS. These accelerators have undergone a major upgrading programme during the last five years so as to meet the stringent requirements of the LHC. This implies that many high-intensity bunches of small emittance and tight spacing (25 ns) be available at the PS extraction energy (26 GeV/c). The upgrading project involved an increase of Linac2 current, new RF systems in the PS Booster and the PS, raising the PS Booster energy from 1 to 1.4 GeV, two-batch filling of the PS, and the installation of high-resolution beam profile measurement devices. With the project entering its final phase and most of the newly installed hardware now being operational, the emphasis switches to producing the nominal LHC beam and tackling the associated beam physics problems. This report describes all the hardware changes related to the upgrading project. (orig.)

Shallow PS-logging by high frequency wave; Koshuha wo mochiita senbu PS kenso

Energy Technology Data Exchange (ETDEWEB)

Nakajima, A; Miyazawa, M; Azuma, H [OYO Corp., Tokyo (Japan)

1996-05-01

This paper describes the following matters on down-hole PS logging in shallow subsurface. Determining an elastic wave velocity structure in shallow subsurface with high accuracy by using down-hole PS logging requires reduction of errors in reading travel time. Therefore, a high-frequency vibration source was fabricated with an objective to raise frequencies of waves used for the measurement. Measurements were made on two holes, A and B, at a measurement interval of 0.5 m, whereas at the hole A a measurement was performed simultaneously by using a normal type (low-frequency) vibration source. A spectral analysis on the waveform record revealed that the frequencies with each vibration source were 127 Hz and 27 Hz for the hole A, 115 Hz for the hole B, and the S/N ratio was all the same for both holes. When the high-frequency vibration source was used, the velocity was determined at accuracy of 5% over the whole length of the shallow section. When the low-frequency vibration source was used, sections with the velocity determining error greater than 5% were found, and it was not possible to derive the velocity structure in the shallow subsurface in fine segments. 3 refs., 8 figs., 2 tabs.

File list: ALL.PSC.10.AllAg.iPS_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available ALL.PSC.10.AllAg.iPS_cells mm9 All antigens Pluripotent stem cell iPS cells SRX9774...30,SRX146524,SRX146547,SRX146522 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.PSC.10.AllAg.iPS_cells.bed ...

EDH 'Millionaire' in PS Division

CERN Multimedia

2001-01-01

Christmas cheer! Left to right: Gerard Lobeau receives a bottle of Champagne from Derek Mathieson and Jurgen De Jonghe in recognition of EDH's millionth document. At 14:33 on Monday 3 December a technician in PS division, Gerard Lobeau, unwittingly became part of an important event in the life of CERN's Electronic Document Handling system (EDH). While ordering some pieces of aluminum for one of the PS's 10Mhz RF cavities, he created EDH document number 1,000,000. To celebrate the event Derek Mathieson (EDH Project Leader) and Jurgen De Jonghe (Original EDH Project Leader) presented Mr Lobeau with a bottle of champagne. As with 93% of material requests, Mr Lobeau's order was delivered within 24 hours. 'I usually never win anything' said Mr Lobeau as he accepted his prize, 'I initially though there may have been a problem with EDH when the document number had so many zeros in it, and was then surprised to get a phone call from you a few minutes later.' The EDH team had been monitoring the EDH document number ...

Permanent magnets including undulators and wigglers

CERN Document Server

Bahrdt, J

2010-01-01

After a few historic remarks on magnetic materials we introduce the basic definitions related to permanent magnets. The magnetic properties of the most common materials are reviewed and the production processes are described. Measurement techniques for the characterization of macroscopic and microscopic properties of permanent magnets are presented. Field simulation techniques for permanent magnet devices are discussed. Today, permanent magnets are used in many fields. This article concentrates on the applications of permanent magnets in accelerators starting from dipoles and quadrupoles on to wigglers and undulators.

Analüütilised voolud psühholoogias ja nende rakendamine pedagoogikas / Aleksander Elango

Index Scriptorium Estoniae

Elango, Aleksander, 1902-2004

2001-01-01

Analüütise psühholoogia kolm koolkonda - S.Freudì koolkond e. päris-psühhoanalüüs, A.Adlerì koolkond e. individuaalpsühholoogia ja C.G.Jungì psühhoanalüüsi ja individuaalpsühholoogia sünteesi luua püüdev koolkond. Analüütise psühholoogia koolkondade ja pedagoogika suhetest

Human iPS Cell-Derived Germ Cells: Current Status and Clinical Potential

Directory of Open Access Journals (Sweden)

Tetsuya Ishii

2014-10-01

Full Text Available Recently, fertile spermatozoa and oocytes were generated from mouse induced pluripotent (iPS cells using a combined in vitro and in vivo induction system. With regard to germ cell induction from human iPS cells, progress has been made particularly in the male germline, demonstrating in vitro generation of haploid, round spermatids. Although iPS-derived germ cells are expected to be developed to yield a form of assisted reproductive technology (ART that can address unmet reproductive needs, genetic and/or epigenetic instabilities abound in iPS cell generation and germ cell induction. In addition, there is still room to improve the induction protocol in the female germline. However, rapid advances in stem cell research are likely to make such obstacles surmountable, potentially translating induced germ cells into the clinical setting in the immediate future. This review examines the current status of the induction of germ cells from human iPS cells and discusses the clinical potential, as well as future directions.

Two-stage optical parametric chirped-pulse amplifier using sub-nanosecond pump pulse generated by stimulated Brillouin scattering compression

Science.gov (United States)

Ogino, Jumpei; Miyamoto, Sho; Matsuyama, Takahiro; Sueda, Keiichi; Yoshida, Hidetsugu; Tsubakimoto, Koji; Miyanaga, Noriaki

2014-12-01

We demonstrate optical parametric chirped-pulse amplification (OPCPA) based on two-beam pumping, using sub-nanosecond pulses generated by stimulated Brillouin scattering compression. Seed pulse energy, duration, and center wavelength were 5 nJ, 220 ps, and ˜1065 nm, respectively. The 532 nm pulse from a Q-switched Nd:YAG laser was compressed to ˜400 ps in heavy fluorocarbon FC-40 liquid. Stacking of two time-delayed pump pulses reduced the amplifier gain fluctuation. Using a walk-off-compensated two-stage OPCPA at a pump energy of 34 mJ, a total gain of 1.6 × 105 was obtained, yielding an output energy of 0.8 mJ. The amplified chirped pulse was compressed to 97 fs.

(PS)2: protein structure prediction server version 3.0.

Science.gov (United States)

Huang, Tsun-Tsao; Hwang, Jenn-Kang; Chen, Chu-Huang; Chu, Chih-Sheng; Lee, Chi-Wen; Chen, Chih-Chieh

2015-07-01

Protein complexes are involved in many biological processes. Examining coupling between subunits of a complex would be useful to understand the molecular basis of protein function. Here, our updated (PS)(2) web server predicts the three-dimensional structures of protein complexes based on comparative modeling; furthermore, this server examines the coupling between subunits of the predicted complex by combining structural and evolutionary considerations. The predicted complex structure could be indicated and visualized by Java-based 3D graphics viewers and the structural and evolutionary profiles are shown and compared chain-by-chain. For each subunit, considerations with or without the packing contribution of other subunits cause the differences in similarities between structural and evolutionary profiles, and these differences imply which form, complex or monomeric, is preferred in the biological condition for the subunit. We believe that the (PS)(2) server would be a useful tool for biologists who are interested not only in the structures of protein complexes but also in the coupling between subunits of the complexes. The (PS)(2) is freely available at http://ps2v3.life.nctu.edu.tw/. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

A paralogous decoy protects Phytophthora sojae apoplastic effector PsXEG1 from a host inhibitor.

Science.gov (United States)

Ma, Zhenchuan; Zhu, Lin; Song, Tianqiao; Wang, Yang; Zhang, Qi; Xia, Yeqiang; Qiu, Min; Lin, Yachun; Li, Haiyang; Kong, Liang; Fang, Yufeng; Ye, Wenwu; Wang, Yan; Dong, Suomeng; Zheng, Xiaobo; Tyler, Brett M; Wang, Yuanchao

2017-02-17

The extracellular space (apoplast) of plant tissue represents a critical battleground between plants and attacking microbes. Here we show that a pathogen-secreted apoplastic xyloglucan-specific endoglucanase, PsXEG1, is a focus of this struggle in the Phytophthora sojae -soybean interaction. We show that soybean produces an apoplastic glucanase inhibitor protein, GmGIP1, that binds to PsXEG1 to block its contribution to virulence. P. sojae , however, secretes a paralogous PsXEG1-like protein, PsXLP1, that has lost enzyme activity but binds to GmGIP1 more tightly than does PsXEG1, thus freeing PsXEG1 to support P. sojae infection. The gene pair encoding PsXEG1 and PsXLP1 is conserved in many Phytophthora species, and the P. parasitica orthologs PpXEG1 and PpXLP1 have similar functions. Thus, this apoplastic decoy strategy may be widely used in Phytophthora pathosystems. Copyright © 2017, American Association for the Advancement of Science.

Sub One-Hundred-PS Pyroelectric Detector Research and Evaluation Program at LASL

International Nuclear Information System (INIS)

McLellan, E.J.; Stotlar, S.C.

1978-01-01

Preliminary devices have been designed and evaluated with 1 ns and 90 ps FWHM CO 2 laser pulses. Good agreement between calculated and measured values of falltime and voltage responsivity has been obtained. The female SMA to male BNC connector appears to be the most desirable easily available package for sub-one-hundred ps CO 2 laser pulses. A new detector with an expected risetime of 13 ps has been designed

Collision induced light-scattering from gaseous sulphurhexafluoride

International Nuclear Information System (INIS)

Pleich, R.

1983-10-01

Modern laser technology permits the measurement of collision induced light-scattering spectra from molecular gases at low densities. Measurements of this type provide a test for the separation dependent pair polarizabilities and pair potentials. For this work the octahedral molecule sulphurhexafluoride (SF 6 , point group symmetry 0sub(h)) has been chosen for which the permanent polarizability anisotropy vanishes. For the experiment an argon ion laser in combination with a double grating monochromator and standard photon counting techniques were used. Both the polarized and depolarized scattering cross sections were obtained. The point dipole-induced-dipole (DID) effect is shown to account for the most of the total scattered intensity. At low frequency shifts the line shape of the SF 6 spectrum is dominated by bound dimers, whereas the intermediate frequency range up to 50 cm -1 is well described by a DID free trajectory binary collision model. The high frequency wings are discussed in terms of the collision induced rotational Raman (CIRR) effect and estimates for the dipole-octopole polarizability E are obtained both from the spectral distribution and from the depolarization ratio. It is demonstrated that the hierarchy of effects constituting the CIRR-model converges slowly for large frequency shifts. (Author)

Model-based design evaluation of a compact, high-efficiency neutron scatter camera

Science.gov (United States)

Weinfurther, Kyle; Mattingly, John; Brubaker, Erik; Steele, John

2018-03-01

This paper presents the model-based design and evaluation of an instrument that estimates incident neutron direction using the kinematics of neutron scattering by hydrogen-1 nuclei in an organic scintillator. The instrument design uses a single, nearly contiguous volume of organic scintillator that is internally subdivided only as necessary to create optically isolated pillars, i.e., long, narrow parallelepipeds of organic scintillator. Scintillation light emitted in a given pillar is confined to that pillar by a combination of total internal reflection and a specular reflector applied to the four sides of the pillar transverse to its long axis. The scintillation light is collected at each end of the pillar using a photodetector, e.g., a microchannel plate photomultiplier (MCP-PM) or a silicon photomultiplier (SiPM). In this optically segmented design, the (x , y) position of scintillation light emission (where the x and y coordinates are transverse to the long axis of the pillars) is estimated as the pillar's (x , y) position in the scintillator "block", and the z-position (the position along the pillar's long axis) is estimated from the amplitude and relative timing of the signals produced by the photodetectors at each end of the pillar. The neutron's incident direction and energy is estimated from the (x , y , z) -positions of two sequential neutron-proton scattering interactions in the scintillator block using elastic scatter kinematics. For proton recoils greater than 1 MeV, we show that the (x , y , z) -position of neutron-proton scattering can be estimated with < 1 cm root-mean-squared [RMS] error and the proton recoil energy can be estimated with < 50 keV RMS error by fitting the photodetectors' response time history to models of optical photon transport within the scintillator pillars. Finally, we evaluate several alternative designs of this proposed single-volume scatter camera made of pillars of plastic scintillator (SVSC-PiPS), studying the effect of

Marxism as permanent revolution

NARCIS (Netherlands)

van Ree, E.

2013-01-01

This article argues that the 'permanent revolution' represented the dominant element in Karl Marx and Friedrich Engels' political discourse, and that it tended to overrule considerations encapsulated in 'historical materialism'. In Marx and Engels's understanding, permanent revolution did not

Perceptions of Community Health Workers (CHWs/PS in the U.S.-Mexico Border HEART CVD Study

Directory of Open Access Journals (Sweden)

Hector G. Balcazar

2014-02-01

Full Text Available Although prior research has shown that Community Health Workers/Promotores de Salud (CHW/PS can facilitate access to care, little is known about how CHW/PS are perceived in their community. The current study reports the findings of a randomized telephone survey conducted in a high-risk urban community environment along the U.S.-Mexico border. In preparation for a community-based CHW/PS intervention called the HEART ecological study, the survey aimed to assess perceptions of CHW/PS, availability and utilization of community resources (recreational and nutrition related and health behaviors and intentions. A total of 7,155 calls were placed to complete 444 surveys in three zip codes in El Paso, Texas. Results showed that participants felt that healthful community resources were available, but utilization was low and variable: 35% reported going to a park, 20% reported having taken a health class, few reported using a gym (12%, recreation center (8%, or YMCA/YWCA (0.9%. Awareness and utilization of CHW/PS services were low: 20% of respondents had heard of CHW/PS, with 8% reporting previous exposure to CHW/PS services. Upon review of a definition of CHW/PS, respondents expressed positive views of CHW/PS and their value in the healthcare system. Respondents who had previous contact with a CHW/PS reported a significantly more positive perception of the usefulness of CHW/PS (p = 0.006, were more likely to see CHW/PS as an important link between providers and patients (p = 0.008, and were more likely to ask a CHW/PS for help (p = 0.009. Participants who utilized CHW/PS services also had significantly healthier intentions to reduce fast food intake. Future research is needed to evaluate if CHW/PS can facilitate utilization of available community resources such as recreational facilities among Hispanic border residents at risk for CVD.

LS1 Report: PS Booster prepares for beam

CERN Multimedia

Katarina Anthony

2014-01-01

With Linac2 already up and running, the countdown to beam in the LHC has begun! The next in line is the PS Booster, which will close up shop to engineers early next week. The injector will be handed over to the Operations Group who are tasked with getting it ready for active duty.   Taken as we approach the end of LS1 activities, this image shows where protons will soon be injected from Linac2 into the four PS Booster rings. Over the coming two months, the Operations Group will be putting the Booster's new elements through their paces. "Because of the wide range of upgrades and repairs carried out in the Booster, we have a very full schedule of tests planned for the machine," says Bettina Mikulec, PS Booster Engineer in Charge. "We will begin with cold checks; these are a wide range of tests carried out without beam, including system tests with power on/off and with varying settings, as well as verification of the controls system and timings." Amon...

File list: DNS.PSC.50.AllAg.iPS_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available DNS.PSC.50.AllAg.iPS_cells hg19 DNase-seq Pluripotent stem cell iPS cells SRX040379...,SRX040378,SRX135563,SRX040376,SRX040377,SRX189427,SRX189400,SRX189399 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.PSC.50.AllAg.iPS_cells.bed ...

File list: His.PSC.50.AllAg.iPS_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available His.PSC.50.AllAg.iPS_cells mm9 Histone Pluripotent stem cell iPS cells SRX977417,SR...RX127376,SRX146530,SRX146522,SRX146547,SRX333561,SRX035985,SRX1090869 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/His.PSC.50.AllAg.iPS_cells.bed ...

Density functional theory study of bulk and single-layer magnetic semiconductor CrPS4

Science.gov (United States)

Zhuang, Houlong L.; Zhou, Jia

2016-11-01

Searching for two-dimensional (2D) materials with multifunctionality is one of the main goals of current research in 2D materials. Magnetism and semiconducting are certainly two desirable functional properties for a single 2D material. In line with this goal, here we report a density functional theory (DFT) study of bulk and single-layer magnetic semiconductor CrPS4. We find that the ground-state magnetic structure of bulk CrPS4 exhibits the A-type antiferromagnetic ordering, which transforms to ferromagnetic (FM) ordering in single-layer CrPS4. The calculated formation energy and phonon spectrum confirm the stability of single-layer CrPS4. The band gaps of FM single-layer CrPS4 calculated with a hybrid density functional are within the visible-light range. We also study the effects of FM ordering on the optical absorption spectra and band alignments for water splitting, indicating that single-layer CrPS4 could be a potential photocatalyst. Our work opens up ample opportunities of energy-related applications of single-layer CrPS4.

PS overcomes two serious magnet failures

CERN Multimedia

Maximilien Brice

2003-01-01

Two magnets (no.'s 6 and 19)and a bus bar connection in the PS were found to be faulty during high-voltage tests at the end of the accelerator shutdown. A five-week repair schedule was quickly devised. A team of mechanics, technicians and engineers worked at full speed to replace the faulty magnets, succeeding in limiting the delay of the accelerators' spring start-up to two weeks. Pictured here are members of the PS team with the replacement no. 6 magnet. From left to right: In the back row, Frédéric Roussel (Transport DBS), Yves Bernard (Transport DBS), Luc Moreno (Cegelec), Thierry Battimanza (Transport DBS), Raymond Brown (AB/ABP), Thomas Zickler (AT/MEL); at the front, Steven Southern (AT/VAC), Thierry Gaidon (Brun & Sorensen), Philippe Vidales (Cegelec), Daniel Aubert (Cegelec), Jerome Cachet (Transport DBS), Jose Manual Gomes de Faria (AT/MEL), Eric Page (AT/VAC).

Sofrimento psíquico e trabalho

Directory of Open Access Journals (Sweden)

Sarah Rosa Salles Vieira

2014-03-01

Full Text Available O presente artigo aprofunda questões clínico-téoricas relacionadas especificamente ao trabalho docente e ao sofrimento psíquico a ele relacionado a partir da observação clínica e vivência grupal nos atendimentos terapêuticos ocupacionais realizados no Hospital do Servidor Público Estadual de São Paulo "Francisco Morato de Oliveira" (HSPE-FMO. Partindo dos estudos acerca da Psicopatologia do Trabalho de Christophe Dejours, do trabalho docente e do relato de um caso clínico, caracteriza a problemática do sofrimento no trabalho, os sistemas de defesa contra este sofrimento, a ameaça à subjetividade do próprio trabalhador, as representações e conflitos vivenciados no trabalho docente, bem como a relação aditiva estabelecida como uma estratégia inconsciente de sobrevivência psíquica.

In-situ preparation of poly(ethylene oxide)/Li3PS4 hybrid polymer electrolyte with good nanofiller distribution for rechargeable solid-state lithium batteries

Science.gov (United States)

Chen, Shaojie; Wang, Junye; Zhang, Zhihua; Wu, Linbin; Yao, Lili; Wei, Zhenyao; Deng, Yonghong; Xie, Dongjiu; Yao, Xiayin; Xu, Xiaoxiong

2018-05-01

Nano-sized fillers in a polymer matrix with good distribution can play a positive role in improving polymer electrolytes in the aspects of ionic conductivity, mechanical property and electrochemical performance of Li-ion cells. Herein, polyethylene oxide (PEO)/Li3PS4 hybrid polymer electrolyte is prepared via a new in-situ approach. The ionic conductivities of the novel hybrid electrolytes with variable proportions are measured, and the optimal electrolyte of PEO-2%vol Li3PS4 presents a considerable ionic conductivity of 8.01 × 10-4 S cm-1 at 60 °C and an electrochemical window up to 5.1 V. The tests of DSC and EDXS reveal that the Li3PS4 nanoparticles with better distribution, as active fillers scattering in the PEO, exhibit a positive effect on the transference of lithium ion and electrochemical interfacial stabilities. Finally, the assembled solid-state LiFePO4/Li battery presents a decent cycling performance (80.9% retention rate after 325 cycles at 60 °C) and excellent rate capacities with 153, 143, 139 and 127 mAh g-1 at the discharging rate of 0.1 C, 0.2 C, 0.5 C and 1 C at 60 °C. It is fully proved that it is an advanced strategy to preparing the new organic/inorganic hybrid electrolytes for lithium-ion batteries applications.

Rab21, a Novel PS1 Interactor, Regulates γ-Secretase Activity via PS1 Subcellular Distribution.

Science.gov (United States)

Sun, Zhenzhen; Xie, Yujie; Chen, Yintong; Yang, Qinghu; Quan, Zhenzhen; Dai, Rongji; Qing, Hong

2018-05-01

γ-Secretase has been a therapeutical target for its key role in cleaving APP to generate β-amyloid (Aβ), the primary constituents of senile plaques and a hallmark of Alzheimer's disease (AD) pathology. Recently, γ-secretase-associating proteins showed promising role in specifically modulating APP processing while sparing Notch signaling; however, the underlying mechanism is still unclear. A co-immunoprecipitation (Co-IP) coupled with mass spectrometry proteomic assay for Presenilin1 (PS1, the catalytic subunit of γ-secretase) was firstly conducted to find more γ-secretase-associating proteins. Gene ontology analysis of these results identified Rab21 as a potential PS1 interacting protein, and the interaction between them was validated by reciprocal Co-IP and immunofluorescence assay. Then, molecular and biochemical methods were used to investigate the effect of Rab21 on APP processing. Results showed that overexpression of Rab21 enhanced Aβ generation, while silencing of Rab21 reduced the accumulation of Aβ, which resulted due to change in γ-secretase activity rather than α- or β-secretase. Finally, we demonstrated that Rab21 had no effect on γ-secretase complex synthesis or metabolism but enhanced PS1 endocytosis and translocation to late endosome/lysosome. In conclusion, we identified a novel γ-secretase-associating protein Rab21 and illustrate that Rab21 promotes γ-secretase internalization and translocation to late endosome/lysosome. Moreover, silencing of Rab21 decreases the γ-secretase activity in APP processing thus production of Aβ. All these results open new gateways towards the understanding of γ-secretase-associating proteins in APP processing and make inhibition of Rab21 a promising strategy for AD therapy.

O Trabalho Psíquico da Intersubjetividade

Directory of Open Access Journals (Sweden)

Maria Inês Assumpção Fernandes

2003-01-01

Full Text Available O presente trabalho procura refletir sobre o trabalho psíquico da intersubjetividade nos grupos. Trata-se de pensá-lo na relação com a ruptura de investimentos durante o processo de Transformação x Criação, em primeiro lugar. A partir desse ponto, discutiremos a relação entre Transformação, Trabalho e Dispositivo. Neste caso pensamos nas possibilidades de intervenção, refletindo sobre a intervenção inpidual e a intervenção grupal. A questão da Transmissão Psíquica entre gerações será focalizada, fundamentalmente, no que se refere aos tempos lógicos do recalque.

NIKHEF: AmPS of electron beam

International Nuclear Information System (INIS)

Anon.

1992-01-01

Now operational at the Dutch National Institute for Nuclear Physics and High Energy Physics (NIKHEF), Amsterdam, is a new tool for studying the electromagnetic properties of nuclei. Called AmPS - Amsterdam pulse stretcher - this ring provides experiments with a smoother, almost continuous supply of electrons

Characterisation of the artificial neural network CiPS for cirrus cloud remote sensing with MSG/SEVIRI

Directory of Open Access Journals (Sweden)

J. Strandgren

2017-11-01

Full Text Available Cirrus clouds remain one of the key uncertainties in atmospheric research. To better understand the properties and physical processes of cirrus clouds, accurate large-scale observations from satellites are required. Artificial neural networks (ANNs have proved to be a useful tool for cirrus cloud remote sensing. Since physics is not modelled explicitly in ANNs, a thorough characterisation of the networks is necessary. In this paper the CiPS (Cirrus Properties from SEVIRI algorithm is characterised using the space-borne lidar CALIOP. CiPS is composed of a set of ANNs for the cirrus cloud detection, opacity identification and the corresponding cloud top height, ice optical thickness and ice water path retrieval from the imager SEVIRI aboard the geostationary Meteosat Second Generation satellites. First, the retrieval accuracy is characterised with respect to different land surface types. The retrieval works best over water and vegetated surfaces, whereas a surface covered by permanent snow and ice or barren reduces the cirrus detection ability and increases the retrieval errors for the ice optical thickness and ice water path if the cirrus cloud is thin (optical thickness less than approx. 0.3. Second, the retrieval accuracy is characterised with respect to the vertical arrangement of liquid, ice clouds and aerosol layers as derived from CALIOP lidar data. The CiPS retrievals show little interference from liquid water clouds and aerosol layers below an observed cirrus cloud. A liquid water cloud vertically close or adjacent to the cirrus clearly increases the average retrieval errors for the optical thickness and ice water path, respectively, only for thin cirrus clouds with an optical thickness below 0.3 or ice water path below 5.0 g m−2. For the cloud top height retrieval, only aerosol layers affect the retrieval error, with an increased positive bias when the cirrus is at low altitudes. Third, the CiPS retrieval error is

Permanent quadrupole magnets

International Nuclear Information System (INIS)

Bush, E.D. Jr.

1976-01-01

A family of quadrupole magnets using a soft iron return yoke and circular cross-section permanent magnet poles were fabricated to investigate the feasibility for use in ion or electron beam focusing applications in accelerators and transport lines. Magnetic field measurements yielded promising results. In fixed-field applications, permanent magnets with sufficient gradients would be a low cost substitute for conventional electromagnets, eliminating the need for power supplies, associated wiring, and cooling. (author)

Application of nuclear resonance scattering for in vivo measurements

International Nuclear Information System (INIS)

Wielopolski, L.; Vartsky, D.; Cohn, S.H.

1983-01-01

Nuclear resonance scattering is applied in our laboratory to measure hepatic and cardiac iron overload. For iron analysis, a gaseous source of 4 mg MnCl 2 is introduced into an evacuated quartz vial. Following irradiation in a nuclear reactor, 56 Mn decays by beta emission to the 847-keV level of 56 Fe, which subsequently decays to the ground state of 56 Fe with a 7 ps half-life. The principal aim of this work is to evaluate the efficacy of the iron chelation therapy. Serial measurements over a time period of 6 to 12 months of a given patient will enable us to see how the iron is removed from the critical organs

Look into the PS Main Control Room (partial view)

CERN Multimedia

1974-01-01

Jean-Pierre Potier at work. The 26 GeV Synchrotron and later also its related machines (Linacs 1,2,3; PS-Booster, LEP-Injector Linacs and Electron-Positron Accumulator; Antiproton Accumulator, Antiproton Collector, Low Energy Antiproton Ring and more recently Antiproton Decelerator) were all controlled from the PS control room situated at the Meyrin site. The SPS and LEP were controlled from a separat control centre on the Prevessin site. In 2005 all controls were transferred to the Prevessin centre.

Multiple bunch-splitting in the PS results and plans

CERN Document Server

Garoby, R

2001-01-01

The nominal longitudinal characteristics of the PS proton beam for the LHC were attained during the year 2000, using a sequence of triple- and double-splittings to divide each PS Booster (PSB) bunch into 12. This method minimizes longitudinal emittance blow-up and preserves a gap, free of particles, in the bunch train. Some of the ideas for alternative bunch trains have also been tested. The performance achieved is described and the sources of limitations are discussed together with the foreseen improvements.

Preliminary Specifications for the PS Transverse Damper Control Interface

CERN Document Server

Blas, A

2003-01-01

The transverse feedback system foreseen for the PS in 2004 is composed of different units to be remotely controlled and monitored: the pick-up amplifiers, the DSPU, the fine delay, the driver and power amplifiers. A special VME unit being dedicated to the pick-up amplifier ("The VMOD-TRX: a device for communication with remote instrumentation", A. Barreira Sevillano, J. Belleman, PS/BD/Note 96-02), the new interface will have to deal with the remaining parts of the loop.

Positron Annihilation Ratio Spectroscopy (PsARS) Applied to Positronium Formation Studies

Science.gov (United States)

2010-03-01

Positron Annihilation Ratio Spectroscopy (PsARS). These experimental techniques have been used for a variety of military and civilian applications ... POSITRON ANNIHILATION RATIO SPECTROSCOPY (PsARS) APPLIED TO POSITRONIUM FORMATION STUDIES THESIS...of Defense, or the United States Government. AFIT/GNE/ENP/10-M07 POSITRON ANNIHILATION RATIO SPECTROSCOPY

Applying persistent scatterer interferometry for surface displacement mapping in the Azul open pit manganese mine (Amazon region) with TerraSAR-X StripMap data

Science.gov (United States)

Athayde Pinto, Carolina de; Paradella, Waldir Renato; Mura, José Claudio; Gama, Fabio Furlan; Ribeiro dos Santos, Athos; Silva, Guilherme Gregório; Hartwig, Marcos Eduardo

2015-01-01

The Azul mining complex, located in the Carajás Mineral Province, Amazon region, encompasses the most important manganese mine in Brazil. Vale S.A. company operates three simultaneous open pit excavations (mines 1, 2, and 3) in the area, which are conducted on rock alteration products of low geomechanical quality related to sandstones, siltstones, and a lateritic cover. In order to monitor ground deformation, 33 TerraSAR-X (TSX-1) StripMap images covering the period of March 2012-April 2013 were used in the investigation. An advanced differential interferometric synthetic aperture radar (A-DInSAR) approach based on persistent scatterer interferometry (PSI) using an interferometric point target analysis algorithm was applied, and the results showed that most of the area was considered stable during the time span of the synthetic aperture radar acquisitions. However, persistent scatterers (PS) with high deformation rates were mapped over a waste pile, probably related to settlements, and also along the north flank of mine 1, indicative of cut slope movements toward the center of the pit. A spatial relationship of geological structures with PS was observed for this sector of the mine, given by PS showing deformation rates concentrated along a structural corridor with faults, fractures, and folds related to the Carajás fault system. Though only ground-based radar measurements for wall benches of mine 1 were available for a short time period of the TSX-1 coverage, the PS movement patterns showed concordance with geotechnical field measurements. The investigation emphasized the important role that satellite-based A-DInSAR can play for deformation monitoring and risk assessment in this kind of mining area.

Network structure control of binary mixed langmuir monolayers of homo-PS and PS-b-P2VP.

Science.gov (United States)

Wen, Gangyao

2010-03-25

Our recent work showed there existed a composition window for mixed Langmuir monolayers of homopolystyrene (h-PS) and a symmetric diblock copolymer polystyrene-block-poly(2-vinylpyridine) (PS-b-P2VP) to form necklace-network structures at the air/water interface. In order to study further the possible mechanism and control the network structure (i.e., surface coverage and nanoaggregate diameter), effects of spreading solution concentration and volume, subphase temperature, and transfer pressure on the network structure were studied by the Langmuir monolayer technique and tapping mode atomic force microscopy. With the increase of transfer pressure, there existed a novel nonlinear behavior for the nanoaggregate diameter first to increase, then to decrease, and finally to increase again, while the surface coverage tended to increase step by step. Moreover, with the elevation of temperature, chain motion between the adjoining nanoaggregates tended to be improved and thus the nanoaggregate diameter tended to be more uniform.

The development of the Asian Forum for Polar Sciences (AFoPS)

Science.gov (United States)

Kim, Yeadong; Jeong, Jihoon

2015-12-01

The Asian Forum for Polar Sciences (AFoPS), an international forum of Asian polar research institutes, was established for the advancement of polar sciences among its members in 2004. The Forum has served as an important medium of Asian collective endeavors for polar affairs in human and information exchange, research collaboration, and logistics cooperation for the last decade. The historical development of the AFoPS in retrospect can be divided into four phases: inception and establishment (2003-2004), growth and expansion (2005-2007), review and restructuring (2008-2011), and achievements and further measures (2012-2014). The progress of the AFoPS has not been linear and this trend will continue into the next decades. The Forum, however, clearly made achievements in this period of time, realizing multilateral research and logistics cooperation that would have been previously unimaginable; by doing so, it has laid the foundation for the future. Responsible for a great portion of the world's polar activities, the AFoPS will rise to meet the expectations of the world by producing notable research output, initiating international cooperative programs, and supporting non-polar Asian countries with education and research collaboration. These are the tasks of the AFoPS for the next decade and they require strategy that promotes and facilitates collaboration in a practical way and draws attention of non-polar Asian countries to the polar sciences.

Paper sludge (PS) to bioethanol: Evaluation of virgin and recycle mill sludge for low enzyme, high-solids fermentation.

Science.gov (United States)

Boshoff, Sonja; Gottumukkala, Lalitha Devi; van Rensburg, Eugéne; Görgens, Johann

2016-03-01

Paper sludge (PS) from the paper and pulp industry consists primarily of cellulose and ash and has significant potential for ethanol production. Thirty-seven PS samples from 11 South African paper and pulp mills exhibited large variation in chemical composition and resulting ethanol production. Simultaneous saccharification and fermentation (SSF) of PS in fed-batch culture was investigated at high solid loadings and low enzyme dosages. Water holding capacity and viscosity of the PS influenced ethanol production at elevated solid loadings of PS. High viscosity of PS from virgin pulp mills restricted the solid loading to 18% (w/w) at an enzyme dosage of 20 FPU/gram dry PS (gdPS), whereas an optimal solid loading of 27% (w/w) was achieved with corrugated recycle mill PS at 11 FPU/gdPS. Ethanol concentration and yield of virgin pulp and corrugated recycle PS were 34.2g/L at 66.9% and 45.5 g/L at 78.2%, respectively. Copyright © 2015 Elsevier Ltd. All rights reserved.

a Proposed Benchmark Problem for Scatter Calculations in Radiographic Modelling

Science.gov (United States)

Jaenisch, G.-R.; Bellon, C.; Schumm, A.; Tabary, J.; Duvauchelle, Ph.

2009-03-01

Code Validation is a permanent concern in computer modelling, and has been addressed repeatedly in eddy current and ultrasonic modeling. A good benchmark problem is sufficiently simple to be taken into account by various codes without strong requirements on geometry representation capabilities, focuses on few or even a single aspect of the problem at hand to facilitate interpretation and to avoid that compound errors compensate themselves, yields a quantitative result and is experimentally accessible. In this paper we attempt to address code validation for one aspect of radiographic modeling, the scattered radiation prediction. Many NDT applications can not neglect scattered radiation, and the scatter calculation thus is important to faithfully simulate the inspection situation. Our benchmark problem covers the wall thickness range of 10 to 50 mm for single wall inspections, with energies ranging from 100 to 500 keV in the first stage, and up to 1 MeV with wall thicknesses up to 70 mm in the extended stage. A simple plate geometry is sufficient for this purpose, and the scatter data is compared on a photon level, without a film model, which allows for comparisons with reference codes like MCNP. We compare results of three Monte Carlo codes (McRay, Sindbad and Moderato) as well as an analytical first order scattering code (VXI), and confront them to results obtained with MCNP. The comparison with an analytical scatter model provides insights into the application domain where this kind of approach can successfully replace Monte-Carlo calculations.

Contribution of defective PS recognition and efferocytosis to chronic inflammation and autoimmunity

Directory of Open Access Journals (Sweden)

Stanley Gititu Kimani

2014-11-01

Full Text Available Rapid and efficient clearance of apoptotic cells results in elimination of auto-antigens and provides a strong anti-inflammatory and immunosuppressive signal to prevent autoimmunity. While professional and non-professional phagocytes utilize a wide array of surface receptors to recognize apoptotic cells, recognition of phosphatidylserine (PS on apoptotic cells by PS receptors on phagocytes is emblematic signal for efferocytosis in metazoans. PS-dependent efferocytosis is associated with production of anti-inflammatory factors such as IL-10 and TGF-β that function, in part, to maintain tolerance to auto-antigens. In contrast, when apoptotic cells fail to be recognized and processed for degradation, auto-antigens persist, which can trigger immune activation leading to autoantibody production and autoimmunity. Despite the fact that genetic mouse models clearly demonstrate that loss of PS receptors can lead to age-dependent autoimmune diseases reminiscent of systemic lupus erythematosus (SLE, link between PS and defective clearance in chronic inflammation and human autoimmunity is not well delineated. In this hypothesis and theory, we review emerging questions developing in the field that may be of relevance to SLE and human autoimmunity.

An investigation into radiosensitizer mechanisms using o-Ps lifetime measurements

International Nuclear Information System (INIS)

Beling, C.D.; Smith, F.A.

1982-01-01

Lifetime measurements have been made in a number of radiosensitizer solutions as a function of both concentration and temperature. The o-Ps yields, which were corrected for chemical quenching, showed that these compounds are strong Ps inhibitors. The temperature dependence of the yields in Misonidazole/water and Misonidazole/ethanol solutions may be associated either with the different electron solvation times in the two solvents, or with changes in electron mobility. (Auth.)

31 CFR 515.335 - Permanent resident alien.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Permanent resident alien. 515.335... Definitions § 515.335 Permanent resident alien. As used in § 515.208, the term permanent resident alien means an alien lawfully admitted for permanent residence into the United States. [61 FR 37386, July 18...

Dense arrays of cobalt nanorods as rare-earth free permanent magnets.

Science.gov (United States)

Anagnostopoulou, E; Grindi, B; Lacroix, L-M; Ott, F; Panagiotopoulos, I; Viau, G

2016-02-21

We demonstrate in this paper the feasibility to elaborate rare-earth free permanent magnets based on cobalt nanorods assemblies with energy product (BH)max exceeding 150 kJ m(-3). The cobalt rods were prepared by the polyol process and assembled from wet suspensions under a magnetic field. Magnetization loops of dense assemblies with remanence to a saturation of 0.99 and squareness of 0.96 were measured. The almost perfect M(H) loop squareness together with electron microscopy and small angle neutron scattering demonstrate the excellent alignment of the rods within the assemblies. The magnetic volume fraction was carefully measured by coupling magnetic and thermogravimetric analysis and found in the range from 45 to 55%, depending on the rod diameter and the alignment procedure. This allowed a quantitative assessment of the (BH)max values. The highest (BH)max of 165 kJ m(-3) was obtained for a sample combining a high magnetic volume fraction and a very large M(H) loop squareness. This study shows that this bottom-up approach is very promising to get new hard magnetic materials that can compete in the permanent magnet panorama and fill the gap between the ferrites and the NdFeB magnets.

Characterization of cucurbita maxima phloem serpin-1 (CmPS-1). A developmentally regulated elastase inhibitor.

Science.gov (United States)

Yoo, B C; Aoki, K; Xiang, Y; Campbell, L R; Hull, R J; Xoconostle-Cázares, B; Monzer, J; Lee, J Y; Ullman, D E; Lucas, W J

2000-11-10

We report on the molecular, biochemical, and functional characterization of Cucurbita maxima phloem serpin-1 (CmPS-1), a novel 42-kDa serine proteinase inhibitor that is developmentally regulated and has anti-elastase properties. CmPS-1 was purified to near homogeneity from C. maxima (pumpkin) phloem exudate and, based on microsequence analysis, the cDNA encoding CmPS-1 was cloned. The association rate constant (k(a)) of phloem-purified and recombinant His(6)-tagged CmPS-1 for elastase was 3.5 +/- 1.6 x 10(5) and 2.7 +/- 0.4 x 10(5) m(-)(1) s(-)(1), respectively. The fraction of complex-forming CmPS-1, X(inh), was estimated at 79%. CmPS-1 displayed no detectable inhibitory properties against chymotrypsin, trypsin, or thrombin. The elastase cleavage sites within the reactive center loop of CmPS-1 were determined to be Val(347)-Gly(348) and Val(350)-Ser(351) with a 3:2 molar ratio. In vivo feeding assays conducted with the piercing-sucking aphid, Myzus persicae, established a close correlation between the developmentally regulated increase in CmPS-1 within the phloem sap and the reduced ability of these insects to survive and reproduce on C. maxima. However, in vitro feeding experiments, using purified phloem CmPS-1, failed to demonstrate a direct effect on aphid survival. Likely roles of this novel phloem serpin in defense against insects/pathogens are discussed.

Tribology and Microstructure of PS212 with a Cr2O3 Seal Coat

Science.gov (United States)

Sliney, Harold E.; Benoy, Patricia A.; Korenyi-Both, Andras; Dellacorte, Christopher

1994-01-01

PS212 is a plasma sprayed metal bonding chrome carbide coating with solid lubricant additives which has lubricating properties at temperatures up to about 900 deg C. The coating is diamond ground to achieve an acceptable tribological surface. But, as with many plasma spray coatings, PS212 is not fully-dense. In this study, a chromium oxide base seal coating is used in an attempt to seal any porosity that is open to the surface of the PS212 coating, and to study the effect of the sealant on the tribological properties of PS212. The results indicate that the seal coating reduces friction and wear when it is applied and then diamond ground leaving a thin layer of seal coating which fills in the surface pits of the PS212 coating.

At PS170 (APPLE)

CERN Multimedia

CERN PhotoLab

1983-01-01

APPLE stands for Antiproton-Proton to Pair of LEptons (an acronym of the ancestor experiment PAPLEP), the PS170 experiment setup at LEAR to study e+e-pair production in antiproton-proton annihilation by Padova-(CEN) Saclay- Torino Collaboration. It consisted of a liquid hydrogen target surrounded by several layers of proportional chambers in the vertical field of a C-magnet (this photo), a gas Cerenkov counter, wire chambers, hodoscopes, and an electromagnetic calorimeter (see photo 8302539X, 8302540X). See also photo 8301539X for the setup assembly at an early stage.

Lawful Permanent Residents - Annual Report

Data.gov (United States)

Department of Homeland Security — A lawful permanent resident (LPR) or 'green card' recipient is defined by immigration law as a person who has been granted lawful permanent residence in the United...

21 CFR 886.4445 - Permanent magnet.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Permanent magnet. 886.4445 Section 886.4445 Food... DEVICES OPHTHALMIC DEVICES Surgical Devices § 886.4445 Permanent magnet. (a) Identification. A permanent magnet is a nonelectric device that generates a magnetic field intended to find and remove metallic...

Improvement of Data Acquisition of the BRTR (PS-43) Seismic Array

Science.gov (United States)

Ozel, N. M.; Kocak, S.; Semin, K. U.; Necmioglu, O.; Destici, T. C.; Teoman, U.

2010-05-01

Bogazici University, Kandilli Observatory and Earthquake Research Institute(KOERI) is currently operating the BRTR( PS-43) seismic arrays located in the vicinity of Ankara and town Keskin, providing real-time data to IDC. PS-43 is composed of two sub-arrays, the medium-period array with a ~45km radius located in Ankara and the short-period array with ~3 km radius located in Keskin. In 2009, data availabilty of the BRTR is exceeded %98 that value is the requirment of IDC. Substantial contribution to obtain this availabiliy is implementing the improvements that mainly replacement of the grid type parabolic antennas with the heavy-duty dish antennas at necessary sites called the repeater sites RE-BRTR (CCF), RE-PS43 (Mt. Elmadag), CF-PS43 (Central Recording Building) and all MP sites. Even this renewed system is at the tentative stage, communication status of the seismic arrays are solid and continuous. BRTR is expecting another improvement, June 2010, about the power system at Mt. Elmadag and the MP site BR237. Completion of this improvement will be stabilize of our current mission.

Muon energy estimate through multiple scattering with the MACRO detector

CERN Document Server

Ambrosio, M; Auriemma, G; Bakari, D; Baldini, A; Barbarino, G C; Barish, B C; Battistoni, G; Becherini, Y; Bellotti, R; Bemporad, C; Bernardini, P; Bilokon, H; Bloise, C; Bower, C; Brigida, M; Bussino, S; Cafagna, F; Calicchio, M; Campana, D; Candela, A; Carboni, M; Caruso, R; Cassese, F; Cecchini, S; Cei, F; Chiarella, V; Choudhary, B C; Coutu, S; Cozzi, M; De Cataldo, G; De Deo, M; Dekhissi, H; De Marzo, C; De Mitri, I; Derkaoui, J; De Vincenzi, M; Di Credico, A; Dincecco, M; Erriquez, O; Favuzzi, C; Forti, C; Fusco, P; Giacomelli, G; Giannini, G; Giglietto, N; Giorgini, M; Grassi, M; Gray, L; Grillo, A; Guarino, F; Gustavino, C; Habig, A; Hanson, K; Heinz, R; Iarocci, E; Katsavounidis, E; Katsavounidis, I; Kearns, E; Kim, H; Kyriazopoulou, S; Lamanna, E; Lane, C; Levin, D S; Lindozzi, M; Lipari, P; Longley, N P; Longo, M J; Loparco, F; Maaroufi, F; Mancarella, G; Mandrioli, G; Margiotta, A; Marini, A; Martello, D; Marzari-Chiesa, A; Mazziotta, M N; Michael, D G; Monacelli, P; Montaruli, T; Monteno, M; Mufson, S; Musser, J; Nicolò, D; Nolty, R; Orth, C; Osteria, G; Palamara, O; Patera, V; Patrizii, L; Pazzi, R; Peck, C W; Perrone, L; Petrera, S; Pistilli, P; Popa, V; Rainó, A; Reynoldson, J; Ronga, F; Rrhioua, A; Satriano, C; Scapparone, E; Scholberg, K; Sciubba, A; Serra, P; Sioli, M; Sirri, G; Sitta, M; Spinelli, P; Spinetti, M; Spurio, M; Steinberg, R; Stone, J L; Sulak, L R; Surdo, A; Tarle, G; Tatananni, E; Togo, V; Vakili, M; Walter, C W; Webb, R

2002-01-01

Muon energy measurement represents an important issue for any experiment addressing neutrino-induced up-going muon studies. Since the neutrino oscillation probability depends on the neutrino energy, a measurement of the muon energy adds an important piece of information concerning the neutrino system. We show in this paper how the MACRO limited streamer tube system can be operated in drift mode by using the TDCs included in the QTPs, an electronics designed for magnetic monopole search. An improvement of the space resolution is obtained, through an analysis of the multiple scattering of muon tracks as they pass through our detector. This information can be used further to obtain an estimate of the energy of muons crossing the detector. Here we present the results of two dedicated tests, performed at CERN PS-T9 and SPS-X7 beam lines, to provide a full check of the electronics and to exploit the feasibility of such a multiple scattering analysis. We show that by using a neural network approach, we are able to r...

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations.

Science.gov (United States)

Lee, Ju-Hyun; Yu, W Haung; Kumar, Asok; Lee, Sooyeon; Mohan, Panaiyur S; Peterhoff, Corrinne M; Wolfe, Devin M; Martinez-Vicente, Marta; Massey, Ashish C; Sovak, Guy; Uchiyama, Yasuo; Westaway, David; Cuervo, Ana Maria; Nixon, Ralph A

2010-06-25

Macroautophagy is a lysosomal degradative pathway essential for neuron survival. Here, we show that macroautophagy requires the Alzheimer's disease (AD)-related protein presenilin-1 (PS1). In PS1 null blastocysts, neurons from mice hypomorphic for PS1 or conditionally depleted of PS1, substrate proteolysis and autophagosome clearance during macroautophagy are prevented as a result of a selective impairment of autolysosome acidification and cathepsin activation. These deficits are caused by failed PS1-dependent targeting of the v-ATPase V0a1 subunit to lysosomes. N-glycosylation of the V0a1 subunit, essential for its efficient ER-to-lysosome delivery, requires the selective binding of PS1 holoprotein to the unglycosylated subunit and the Sec61alpha/oligosaccharyltransferase complex. PS1 mutations causing early-onset AD produce a similar lysosomal/autophagy phenotype in fibroblasts from AD patients. PS1 is therefore essential for v-ATPase targeting to lysosomes, lysosome acidification, and proteolysis during autophagy. Defective lysosomal proteolysis represents a basis for pathogenic protein accumulations and neuronal cell death in AD and suggests previously unidentified therapeutic targets.

Spectra and relaxation dynamics of the pseudohalide (PS) vibrational bands for Ru(bpy)2(PS)2 complexes, PS = CN, NCS and N3

International Nuclear Information System (INIS)

Compton, Ryan; Gerardi, Helen K.; Weidinger, Daniel; Brown, Douglas J.; Dressick, Walter J.; Heilweil, Edwin J.; Owrutsky, Jeffrey C.

2013-01-01

Highlights: ► Static and transient infrared spectroscopy of pseudohalide bipyridine ruthenium complexes. ► Vibrational energy relaxes faster for the azide than the thiocyanate and cyanide analogs. ► Intramolecular vibrational relaxation is prevalent in cis-Ru(bpy) 2 (N 3 ) 2 . - Abstract: Static and transient infrared spectroscopy were used to investigate cis-Ru(bpy) 2 (N 3 ) 2 (bpy = 2,2′-bipyridine), cis-Ru(bpy) 2 (NCS) 2 , and cis-Ru(bpy) 2 (CN) 2 in solution. The NC stretching IR band for cis-Ru(bpy) 2 (NCS) 2 appears at higher frequency (∼2106 cm −1 in DMSO) than for the free NCS − anion while the IR bands for the azide and cyanide complexes are closer to those of the respective free anions. The vibrational energy relaxation (VER) lifetime for the azide complex is found to be much shorter (∼5 ps) than for either the NCS or CN species (both ∼70 ps in DMSO) and the lifetimes resemble those for each corresponding free anion in solution. However, for cis-Ru(bpy) 2 (N 3 ) 2 , it is determined that the transition frequency depends more on the solvent than the VER lifetime implying that intramolecular vibrational relaxation is predominant over solvent energy-extracting interactions. These results are compared to the behavior of other related metal complexes in solution

The Pan-STARRS PS1 Image Processing Pipeline

Science.gov (United States)

Magnier, E.

The Pan-STARRS PS1 Image Processing Pipeline (IPP) performs the image processing and data analysis tasks needed to enable the scientific use of the images obtained by the Pan-STARRS PS1 prototype telescope. The primary goals of the IPP are to process the science images from the Pan-STARRS telescopes and make the results available to other systems within Pan-STARRS. It also is responsible for combining all of the science images in a given filter into a single representation of the non-variable component of the night sky defined as the "Static Sky". To achieve these goals, the IPP also performs other analysis functions to generate the calibrations needed in the science image processing, and to occasionally use the derived data to generate improved astrometric and photometric reference catalogs. It also provides the infrastructure needed to store the incoming data and the resulting data products. The IPP inherits lessons learned, and in some cases code and prototype code, from several other astronomy image analysis systems, including Imcat (Kaiser), the Sloan Digital Sky Survey (REF), the Elixir system (Magnier & Cuillandre), and Vista (Tonry). Imcat and Vista have a large number of robust image processing functions. SDSS has demonstrated a working analysis pipeline and large-scale databasesystem for a dedicated project. The Elixir system has demonstrated an automatic image processing system and an object database system for operational usage. This talk will present an overview of the IPP architecture, functional flow, code development structure, and selected analysis algorithms. Also discussed is the HW highly parallel HW configuration necessary to support PS1 operational requirements. Finally, results are presented of the processing of images collected during PS1 early commissioning tasks utilizing the Pan-STARRS Test Camera #3.

[Permanent education in health: a review].

Science.gov (United States)

Miccas, Fernanda Luppino; Batista, Sylvia Helena Souza da Silva

2014-02-01

To undertake a meta-synthesis of the literature on the main concepts and practices related to permanent education in health. A bibliographical search was conducted for original articles in the PubMed, Web of Science, LILACS, IBECS and SciELO databases, using the following search terms: "public health professional education", "permanent education", "continuing education", "permanent education health". Of the 590 articles identified, after applying inclusion and exclusion criteria, 48 were selected for further analysis, grouped according to the criteria of key elements, and then underwent meta-synthesis. The 48 original publications were classified according to four thematic units of key elements: 1) concepts, 2) strategies and difficulties, 3) public policies and 4) educational institutions. Three main conceptions of permanent education in health were found: problem-focused and team work, directly related to continuing education and education that takes place throughout life. The main strategies for executing permanent education in health are discussion, maintaining an open space for permanent education , and permanent education clusters. The most limiting factor is mainly related to directly or indirect management. Another highlight is the requirement for implementation and maintenance of public policies, and the availability of financial and human resources. The educational institutions need to combine education and service aiming to form critical-reflexive graduates. The coordination between health and education is based as much on the actions of health services as on management and educational institutions. Thus, it becomes a challenge to implement the teaching-learning processes that are supported by critical-reflexive actions. It is necessary to carry out proposals for permanent education in health involving the participation of health professionals, teachers and educational institutions. To undertake a meta-synthesis of the literature on the main concepts and

Local nuclear slope and curvature in high energy pp and pp-bar elastic scattering

Energy Technology Data Exchange (ETDEWEB)

Desgrolard, P. [Lyon-1 Univ., 69 - Villeurbanne (France). Inst. de Physique Nucleaire; Kontros, J.; Lengyel, A.I. [Inst. of Electron Physics, Uzhgorod (Ukraine); Martynov, E.S. [National Academy of Sciences of Ukraine, Kiev (Ukraine). Bogolyubov Inst. for Theoretical Physics

1997-05-01

The local nuclear slope is reconstructed from the experimental angular distributions with a procedure that uses overlapping t-bins, for an energy that ranges from the ISR to the Sp-bar pS and the Tevatron. Predictions of several models of (p-bar,p) elastic scattering at high energy are tested. Only a model with two-components Pomeron and Odderon gives a satisfactory agreement with the (non fitted) slope data. The extreme sensitivity of the local nuclear curvature with the choice for a Pomeron model is emphasized. (author). 30 refs.

File list: ALL.PSC.20.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available ALL.PSC.20.AllAg.iPS_derived_neural_cells hg19 All antigens Pluripotent stem cell iPS derived neural...hive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.PSC.20.AllAg.iPS_derived_neural_cells.bed ...

File list: His.PSC.20.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available His.PSC.20.AllAg.iPS_derived_neural_cells hg19 Histone Pluripotent stem cell iPS derived neural...archive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.20.AllAg.iPS_derived_neural_cells.bed ...

File list: His.PSC.50.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available His.PSC.50.AllAg.iPS_derived_neural_cells hg19 Histone Pluripotent stem cell iPS derived neural...archive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.PSC.50.AllAg.iPS_derived_neural_cells.bed ...

Structure-properties relationships of polyhedral oligomeric silsesquioxane (POSS filled PS nanocomposites

Directory of Open Access Journals (Sweden)

J. J. Schwab

2012-07-01

Full Text Available The polyhedral oligomeric silsesquioxane (POSS additivated polystyrene (PS based nanocomposites were prepared by melt processing and the structure-properties relationships of the POSS-PS systems were compared to those of the neat PS. In order to investigate the effect of these structural parameters on the final properties of the polymer nanocomposites, five different kinds of POSS samples were used, in particular, POSS with different inorganic cage and with different organic pendent groups. The rheological investigation suggests clearly that the POSS acts as a plasticizer and that the processability of the PS was positively modified. The affinity between the POSS samples and the PS matrix was estimated by the calculated theoretical solubility parameters, considering the Hoy’s method and by morphology analysis. Minor difference between the solubility parameter of POSS and the matrix means better compatibility and no aggregation tendency. Furthermore, the POSS loading leads to a decrease of the rigidity, of the glass transition temperature and of the damping factor of the nanocomposite systems. The loading of different POSS molecules with open cage leads to a more pronounced effect on all the investigated properties that the loading of the POSS molecules with closed cage. Moreover, the melt properties are significantly influenced by the type of inorganic framework, by the type of the pendent organic groups and by the interaction between the POSS organic groups and the host matrix, while, the solid state properties appears to be influenced more by the kind of cage.

The adiabatic approximation in multichannel scattering

International Nuclear Information System (INIS)

Schulte, A.M.

1978-01-01

Using two-dimensional models, an attempt has been made to get an impression of the conditions of validity of the adiabatic approximation. For a nucleon bound to a rotating nucleus the Coriolis coupling is neglected and the relation between this nuclear Coriolis coupling and the classical Coriolis force has been examined. The approximation for particle scattering from an axially symmetric rotating nucleus based on a short duration of the collision, has been combined with an approximation based on the limitation of angular momentum transfer between particle and nucleus. Numerical calculations demonstrate the validity of the new combined method. The concept of time duration for quantum mechanical collisions has also been studied, as has the collective description of permanently deformed nuclei. (C.F.)

Elastic Moduli of Permanently Densified Silica Glasses

Science.gov (United States)

Deschamps, T.; Margueritat, J.; Martinet, C.; Mermet, A.; Champagnon, B.

2014-01-01

Modelling the mechanical response of silica glass is still challenging, due to the lack of knowledge concerning the elastic properties of intermediate states of densification. An extensive Brillouin Light Scattering study on permanently densified silica glasses after cold compression in diamond anvil cell has been carried out, in order to deduce the elastic properties of such glasses and to provide new insights concerning the densification process. From sound velocity measurements, we derive phenomenological laws linking the elastic moduli of silica glass as a function of its densification ratio. The found elastic moduli are in excellent agreement with the sparse data extracted from literature, and we show that they do not depend on the thermodynamic path taken during densification (room temperature or heating). We also demonstrate that the longitudinal sound velocity exhibits an anomalous behavior, displaying a minimum for a densification ratio of 5%, and highlight the fact that this anomaly has to be distinguished from the compressibility anomaly of a-SiO2 in the elastic domain. PMID:25431218

N-hexanoyl-L-homoserine lactone-degrading Pseudomonas aeruginosa PsDAHP1 protects zebrafish against Vibrio parahaemolyticus infection.

Science.gov (United States)

Vinoj, Gopalakrishnan; Jayakumar, Rengarajan; Chen, Jiann-Chu; Withyachumnarnkul, Boonsirm; Shanthi, Sathappan; Vaseeharan, Baskaralingam

2015-01-01

Four strains of N-hexanoyl-L-homoserine lactone (AHL)-degrading Pseudomonas spp., named PsDAHP1, PsDAHP2, PsDAHP3, and PsDAHP4 were isolated and identified from the intestine of Fenneropenaeus indicus. PsDAHP1 showed the highest AHL-degrading activity among the four isolates. PsDAHP1 inhibited biofilm-forming exopolysaccharide and altered cell surface hydrophobicity of virulent green fluorescent protein (GFP)-tagged Vibrio parahaemolyticus DAHV2 (GFP-VpDAHV2). Oral administration of PsDAHP1 significantly reduced zebrafish mortality caused by GFP-VpDAHV2 challenge, and inhibited colonisation of GFP-VpDAHV2 in the gills and intestine of zebrafish as evidence by confocal laser scanning microscope and selective plating. Furthermore, zebrafish receiving PsDAHP1-containing feed had increased phagocytic cells of its leucocytes, increased serum activities of superoxide dismutase and lysozyme. The results suggest that Pseudomonas aeruginosa PsDAHP1 could protect zebrafish from V. parahaemolyticus infection by inhibiting biofilm formation and enhancing defence mechanisms of the fish. Copyright © 2014 Elsevier Ltd. All rights reserved.

Periodic permanent magnet focused klystron

Science.gov (United States)

Ferguson, Patrick; Read, Michael; Ives, R Lawrence

2015-04-21

A periodic permanent magnet (PPM) klystron has beam transport structures and RF cavity structures, each of which has permanent magnets placed substantially equidistant from a beam tunnel formed about the central axis, and which are also outside the extent of a cooling chamber. The RF cavity sections also have permanent magnets which are placed substantially equidistant from the beam tunnel, but which include an RF cavity coupling to the beam tunnel for enhancement of RF carried by an electron beam in the beam tunnel.

New Electron Cloud Detectors for the PS Main Magnets

CERN Document Server

Yin Vallgren, Ch; Gilardoni, S; Taborelli, M; Neupert, H; Ferreira Somoza, J

2014-01-01

Electron cloud (EC) has already been observed during normal operation of the PS, therefore it is necessary to study its in fluence on any beam instability for the future LHC Injector Upgrade (LIU). Two new electron cloud detectors have been discussed, developed and installed during the Long Shutdown (LS1) in one of the PS main magnets. The first measurement method is based on current measurement by using a shielded button-type pick-up. Due to the geometry and space limitation in the PS magnet, the button-type pick-up made of a 96%Al2O3 block coated with a thin layer of solvent-based Ag painting, placed 30 degrees to the bottom part of the vacuum chamber was installed in the horizontal direction where the only opening of the magnet coil is. The other newly developed measurement method is based on detection of photons emitted by the electrons from the electron cloud impinging on the vacuum chamber walls. The emitted photons are reected to a quartz window. A MCP-PMT (Micro-Channel Plate Photomultiplier Tube) wit...

Evaluation of spontaneous space closure and development of permanent dentition after extraction of hypomineralized permanent first molars.

Science.gov (United States)

Jälevik, Birgitta; Möller, Marie

2007-09-01

The aim of this study was to evaluate spontaneous space closure, development of the permanent dentition, and need for orthodontic treatment after extraction of permanent first molars due to severe molar-incisor hypomineralization (MIH). Twenty-seven children aged 5.6-12.7 (median 8.2) years had one to four permanent first molars extracted due to severe MIH. Each case was followed up on individual indications 3.8-8.3 (median 5.7) years after extractions. The eruption of the permanent dentition, and space closure were documented by orthopantomograms, casts, photographs, and/or bitewings. Fifteen children were judged to have a favourable spontaneous development of their permanent dentition without any orthodontic intervention. Seven children were or should be subjected to orthodontic treatment for other reasons registered prior to the extraction. Five children were judged to have a treatment at least caused by the extractions, but three of them abstained because of no subjective treatment need. Extraction of permanent first molars severely affected by MIH is a good treatment alternative. Favourable spontaneous space reduction and development of the permanent dentition positioning can be expected without any intervention in the majority of cases extracted prior to the eruption of the second molar.

Modern permanent magnetic materials - preparation and properties

International Nuclear Information System (INIS)

Rodewald, W.

1989-01-01

First of all, the basic properties of the classical (steel, AlNiCo) permanent magnetic materials and the modern rare-earth (RE) permanent magnetic materials are compared. Since the properties of RE permanent magnets depend on the particular production process, the fundamentals of the main industrial processes (powder metallurgy, rapid-solidification technique) are described and the typical properties are explained. Furthermore the production processes in development such as mechanical alloying, melt spinning technique and extrusion upsetting are briefly outlined. For applying the permanent magnets, they have to be completely magnetized. The magnetization behaviour of the various RE permanent magnets is discussed by means of the internal demagnetization curve. Finally the various influences on the temperature stability of RE permanent magnets are compiled. (orig./MM) [de

CNA-motion in a PS - Fn

International Nuclear Information System (INIS)

Singh, M.P.; Mishra, C.K.

1989-12-01

A Finsler space Fn (n > 2), throughout with the projective curvature tensor possessing vanishing covariant derivative, has been called a ''projectively symmetric Finsler space'' and such a space is denoted PS-Fn. The conditions in which an infinitesimal transformation defines non-affine motion with a contra-field, briefly called CNA-motion, are discussed. 7 refs

File list: Pol.PSC.05.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available Pol.PSC.05.AllAg.iPS_derived_neural_cells hg19 RNA polymerase Pluripotent stem cell iPS derived neural... cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Pol.PSC.05.AllAg.iPS_derived_neural_cells.bed ...

File list: Unc.PSC.50.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available Unc.PSC.50.AllAg.iPS_derived_neural_cells hg19 Unclassified Pluripotent stem cell iPS derived neural... cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Unc.PSC.50.AllAg.iPS_derived_neural_cells.bed ...

File list: DNS.PSC.10.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available DNS.PSC.10.AllAg.iPS_derived_neural_cells hg19 DNase-seq Pluripotent stem cell iPS derived neural... cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/DNS.PSC.10.AllAg.iPS_derived_neural_cells.bed ...

MYC cis-Elements in PsMPT Promoter Is Involved in Chilling Response of Paeonia suffruticosa.

Directory of Open Access Journals (Sweden)

Yuxi Zhang

Full Text Available The MPT transports Pi to synthesize ATP. PsMPT, a chilling-induced gene, was previously reported to promote energy metabolism during bud dormancy release in tree peony. In this study, the regulatory elements of PsMPT promoter involved in chilling response were further analyzed. The PsMPT transcript was detected in different tree peony tissues and was highly expressed in the flower organs, including petal, stigma and stamen. An 1174 bp of the PsMPT promoter was isolated by TAIL-PCR, and the PsMPT promoter::GUS transgenic Arabidopsis was generated and analyzed. GUS staining and qPCR showed that the promoter was active in mainly the flower stigma and stamen. Moreover, it was found that the promoter activity was enhanced by chilling, NaCl, GA, ACC and NAA, but inhibited by ABA, mannitol and PEG. In transgenic plants harboring 421 bp of the PsMPT promoter, the GUS gene expression and the activity were significantly increased by chilling treatment. When the fragment from -421 to -408 containing a MYC cis-element was deleted, the chilling response could not be observed. Further mutation analysis confirmed that the MYC element was one of the key motifs responding to chilling in the PsMPT promoter. The present study provides useful information for further investigation of the regulatory mechanism of PsMPT during the endo-dormancy release.

Lawful Permanent Residents Fiscal Year 2015 State

Data.gov (United States)

Department of Homeland Security — Lawful permanent residents (LPRs) are foreign nationals who have been granted the right to reside permanently in the United States. LPRs are also known as 'permanent...

Lawful Permanent Residents Fiscal Year 2014 Country

Data.gov (United States)

Department of Homeland Security — Lawful permanent residents (LPRs) are foreign nationals who have been granted the right to reside permanently in the United States. LPRs are also known as 'permanent...

Lawful Permanent Residents Fiscal Year 2011 State

Data.gov (United States)

Department of Homeland Security — Lawful permanent residents (LPRs) are foreign nationals who have been granted the right to reside permanently in the United States. LPRs are also known as 'permanent...

Lawful Permanent Residents Fiscal Year 2015 Country

Data.gov (United States)

Department of Homeland Security — Lawful permanent residents (LPRs) are foreign nationals who have been granted the right to reside permanently in the United States. LPRs are also known as 'permanent...

Lawful Permanent Residents Fiscal Year 2016 State

Data.gov (United States)

Department of Homeland Security — Lawful permanent residents (LPRs) are foreign nationals who have been granted the right to reside permanently in the United States. LPRs are also known as 'permanent...

Lawful Permanent Residents Fiscal Year 2014 State

Data.gov (United States)

Department of Homeland Security — Lawful permanent residents (LPRs) are foreign nationals who have been granted the right to reside permanently in the United States. LPRs are also known as 'permanent...

Preliminary Evaluation of PS300: A New Self-Lubricating High Temperature Composite Coating for Use to 800 C

Science.gov (United States)

Dellacorte, C.; Edmonds, B. J.

1995-01-01

This paper introduces PS300, a plasma sprayed, self-lubricating composite coating for use in sliding contacts at temperatures to 800 C. PS300 is a metal bonded chrome oxide coating with silver and BaF2/CaF2 eutectic solid lubricant additives. PS300 is similar to PS200, a chromium carbide based coating, which is currently being investigated for a variety of tribological applications. In pin-on-disk testing up to 650 C, PS300 exhibited comparable friction and wear properties to PS200. The PS300 matrix, which is predominantly chromium oxide rather than chromium carbide, does not require diamond grinding and polishes readily with silicon carbide abrasives greatly reducing manufacturing costs compared to PS200. It is anticipated that PS300 has potential for sliding bearing and seal applications in both aerospace and general industry.

checkCIF/PLATON report Datablock: ps75

Indian Academy of Sciences (India)

THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC REFEREE. No syntax errors found. CIF dictionary Interpreting this report. Datablock: ps75. Bond precision:.

Crystal structure of the mixed-metal thiophosphate Nb1.18V0.82PS10

Directory of Open Access Journals (Sweden)

Joobin Sun

2015-03-01

Full Text Available The mixed-metal thiophosphate, Nb1.18V0.82PS10 (niobium vanadium phosphorus decasulfide, has been prepared though solid state reactions using an alkali-metal halide flux. The title compound is isostructural with two-dimensional Nb2PS10. [M2S12] (M = Nb or V dimers built up from two bicapped trigonal prisms and tetrahedral [PS4] units share sulfur atoms to construct 1∞[M2PS10] chains along the a axis. These chains are linked through the disulfide bonds between [PS4] units in adjacent chains to form layers parallel to the ab plane. These layers then stack on top of each other to complete the three-dimensional structure with van der Waals gaps. The M sites are occupied by 59% of Nb and 41% of V and the average M—S and M—M distances in the title compound are in between those of V2PS10 and Nb2PS10. The classical charge balance of the title compound can be represented by [(Nb/V4+]2[P5+][S2−]3[S−]7.

High energy behaviour of the scattering amplitude in the presence of confined channels

International Nuclear Information System (INIS)

Gehlen, G.; Rittenberg, V.

1977-09-01

The two-channel potential scattering problem in three space-dimensions is considered in the case when one channel is permanently confined. Two examples of confining potentials are considered: the harmonic oscillator and the infinite well. The two cases give radically different results: for the infinite well there is no high energy limit; in the case of the harmonic oscillator the amplitude has properties similar to that of dual absorptive models. (orig.) [de

Spin effects in medium-energy electron-3He scattering

International Nuclear Information System (INIS)

van den Brand, J.F.J.; Alarcon, R.; Bauer, T.

1998-01-01

New physics can be accessed by scattering polarized electrons from a polarized 3 He internal gas target. It is discussed how the asymmetries for the reactions 3 vector He(vector e,e'), 3 vector He(vector e,e'p), 3 vector He(vector e,e'n), 3 vector He(vector e,e'd), and 3 vector He(vector e,e'pn) may provide precise information on the S' and the D-wave parts of the 3 He ground-state wave function, the neutron form factors, and the role of spin-dependent reaction mechanism effects. The experiment uses up to 900 MeV (polarized) electrons from the AmPS storage ring in Amsterdam, Netherlands, in combination with large acceptance electron and hadron detectors. (orig.)

PS3 CELL Development for Scientific Computation and Research

Science.gov (United States)

Christiansen, M.; Sevre, E.; Wang, S. M.; Yuen, D. A.; Liu, S.; Lyness, M. D.; Broten, M.

2007-12-01

The Cell processor is one of the most powerful processors on the market, and researchers in the earth sciences may find its parallel architecture to be very useful. A cell processor, with 7 cores, can easily be obtained for experimentation by purchasing a PlayStation 3 (PS3) and installing linux and the IBM SDK. Each core of the PS3 is capable of 25 GFLOPS giving a potential limit of 150 GFLOPS when using all 6 SPUs (synergistic processing units) by using vectorized algorithms. We have used the Cell's computational power to create a program which takes simulated tsunami datasets, parses them, and returns a colorized height field image using ray casting techniques. As expected, the time required to create an image is inversely proportional to the number of SPUs used. We believe that this trend will continue when multiple PS3s are chained using OpenMP functionality and are in the process of researching this. By using the Cell to visualize tsunami data, we have found that its greatest feature is its power. This fact entwines well with the needs of the scientific community where the limiting factor is time. Any algorithm, such as the heat equation, that can be subdivided into multiple parts can take advantage of the PS3 Cell's ability to split the computations across the 6 SPUs reducing required run time by one sixth. Further vectorization of the code can allow for 4 simultanious floating point operations by using the SIMD (single instruction multiple data) capabilities of the SPU increasing efficiency 24 times.

File list: Oth.PSC.05.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available Oth.PSC.05.AllAg.iPS_derived_neural_cells hg19 TFs and others Pluripotent stem cell iPS derived neural...X968908 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.PSC.05.AllAg.iPS_derived_neural_cells.bed ...

Performance studies towards a TOF-PET sensor using Compton scattering at plastic scintillators

Science.gov (United States)

Kuramoto, M.; Nakamori, T.; Gunji, S.; Kamada, K.; Shoji, Y.; Yoshikawa, A.; Aoki, T.

2018-01-01

We have developed a sensor head for a time-of-flight (TOF) PET scanner using plastic scintillators that have a very fast timing property. Given the very small cross section of photoelectric absorption in plastic scintillators at 511 keV, we use Compton scattering in order to compensate for detection efficiency. The detector will consist of two layers of scatterers and absorbers which are made of plastic and inorganic scintillators such as GAGG:Ce, respectively. Signals are read by monolithic Multi Pixel Photon Counters, and with energy deposits and interaction time stamps are being acquired. The scintillators are built to be capable of resolving interaction position in three dimensions, so that our system has also a function of depth-of-interaction (DOI) PET scanners. TOF resolution of ~ 200 ps (FWHM) is achieved in both cases of using the leading-edge discriminator and time-walk correction and using a configuration sensitive to DOI. Both the position resolution and spectroscopy are demonstrated using the prototype data acquisition system, with Compton scattering events subsequently being obtained. We also demonstrated that the background rejection technique using the Compton cone constraint could be valid with our system.

Psühholoog Pulver: uskumatu. Kurb. Õõvastav / Aleksander Pulver ; intervjueerinud Tiina Jõgeda

Index Scriptorium Estoniae

Pulver, Aleksander, 1956-

2009-01-01

Vestlus Tallinna Ülikooli psühholoogia instituudi direktori Aleksander Pulveriga pedofiilia teemal. Psühholoogi seisukohavõtud laste õiguste kaitsjana ja koolihariduse uuendajana silma paistnud Kaur Hansoni pedofiiliasüüdistuste kohta

Topology optimized permanent magnet systems

DEFF Research Database (Denmark)

Bjørk, Rasmus; Bahl, Christian; Insinga, Andrea Roberto

2017-01-01

Topology optimization of permanent magnet systems consisting of permanent magnets, high permeability iron and air is presented. An implementation of topology optimization for magnetostatics is discussed and three examples are considered. The Halbach cylinder is topology optimized with iron...... and an increase of 15% in magnetic efficiency is shown. A topology optimized structure to concentrate a homogeneous field is shown to increase the magnitude of the field by 111%. Finally, a permanent magnet with alternating high and low field regions is topology optimized and a ΛcoolΛcool figure of merit of 0...

Object permanence in lemurs.

Science.gov (United States)

Deppe, Anja M; Wright, Patricia C; Szelistowski, William A

2009-03-01

Object permanence, the ability to mentally represent objects that have disappeared from view, should be advantageous to animals in their interaction with the natural world. The objective of this study was to examine whether lemurs possess object permanence. Thirteen adult subjects representing four species of diurnal lemur (Eulemur fulvus rufus, Eulemur mongoz, Lemur catta and Hapalemur griseus) were presented with seven standard Piagetian visible and invisible object displacement tests, plus one single visible test where the subject had to wait predetermined times before allowed to search, and two invisible tests where each hiding place was made visually unique. In all visible tests lemurs were able to find an object that had been in clear view before being hidden. However, when lemurs were not allowed to search for up to 25-s, performance declined with increasing time-delay. Subjects did not outperform chance on any invisible displacements regardless of whether hiding places were visually uniform or unique, therefore the upper limit of object permanence observed was Stage 5b. Lemur species in this study eat stationary foods and are not subject to stalking predators, thus Stage 5 object permanence is probably sufficient to solve most problems encountered in the wild.

Reports of the study group for neutron scattering

International Nuclear Information System (INIS)

1982-01-01

This report covers the activities from July 1980 to December 1981. Within this period, the project for reactor extension (including a thermal neutron source and a hall for the neutron guide), was worked out in detail. Like the Fritz-Haber Institute, the Institute for Crystallography of Tuebingen University decided to send a number of guest-scientists for studies at the Hahn-Meitner Institute on a permanent basis. The HMI also organized the 5th International Conference on Small-Angle Scattering, held in Berlin in October 1980. The scientific research work was mainly concerned with magnetic systems, molecular crystals, and the determination of electron densities. (orig.)

Phosphatidylserine-dependent anti-prothrombin antibodies (aPS/PT) in infliximab-treated patients with inflammatory bowel diseases.

Science.gov (United States)

Malíčková, Karin; Ďuricová, Dana; Bortlík, Martin; Janatková, Ivana; Zima, Tomáš; Lukáš, Milan

2013-04-01

To (1) examine the occurrence and concentrations of aPS/PT and aPL in inflammatory bowel disease (IBD) patients at the beginning of and during anti-TNF-alpha therapy with infliximab; (2) investigate the link of the aPS/PT and aPL presence with antibodies to infliximab (ATI) formation; and (3) examine possible clinical consequences of aPS/PT and/or aPL positivity in IBD patients. Thirty (30) IBD patients treated with infliximab were analyzed regarding aPS/PT, aPL, and ATI antibody serum levels by standardized ELISAs at treatment weeks 2 (W2) and 14 (W14). At W2, 40 % of infliximab-treated patients had elevated aPS/PT and 16.7 % had elevated aPL serum levels. At W14, the proportion of aPS/PT-positive sera decreased to 16.6 %, whereas aPL distribution remained unchanged. Moreover, concentrations of aPS/PT have shown significant differences at W2 (16.64 [10.06; 33.06] U for IgG and 18.46 [9.18; 32.48] U for IgM) and at W14 (8.24 [2.78; 19.82] U for IgG and 8.57 [5.55; 26.82] U for IgM), p = 0.009 and p = 0.003, respectively. In ATI-positive samples, aPS/PT IgG were more frequent (p = 0.001 for W2 and p = 0.003 for W14), whereas aPS/PT IgM and aPL IgG/IgM did not show such association. Higher concentrations of aPS/PT IgG and IgM were found in IBD patients at the beginning of the biological treatment period compared to the maintenance treatment period. Moreover, aPS/PT IgG were more frequent in ATI-positive individuals, which was not observed in aPL. We speculate that there is a relationship between the aPS/PT and the severity of inflammation and auto-aggressive processes in IBD.

Longitudinal coupled-bunch instability studies in the PS

CERN Document Server

Damerau, H

2017-01-01

The main longitudinal limitation for LHC-type beams inthe PS are coupled-bunch instabilities. A dedicated proto-typefeedbacksystemusingaFinemetcavityasalongitudinalkicker has been installed. Extensive tests with beam havebeen performed to explore the intensity reach with this feed-back. The maximum intensity with nominal longitudinalemittance at PS extraction has been measured, as well as theemittance required to keep the beam longitudinally stableat the design intensity for the High-Luminosity LHC (HL-LHC). A higher-harmonic cavity is a complementary op-tion to extend the intensity reach beyond the capabilities ofthe coupled-bunch feedback. Preliminary machine develop-ment (MD) studies operating one20MHzor one40MHzRF system as a higher harmonic at the flat-top indicate thebeneficial effect on longitudinal beam stability

Design study of the large hadron electron collider and a rapid cycling synchrotron as alternative to the PS booster upgrade at CERN

International Nuclear Information System (INIS)

Fitterer, Miriam

2013-01-01

With the Large Hadron Collider (LHC) the exploration of particle physics at center of mass energies at the TeV scale has begun. To extend the discovery potential of the LHC, a major upgrade is foreseen around 2020 of the LHC itself and the LHC injectors - the chain of accelerators preparing the beam for the LHC. One of the injectors - the second one in the chain - is the Proton Synchrotron (PS) Booster. Its performance is currently limited by the space-charge effect, which is the effect of the electromagnetic field of the particle beam on itself. This effect becomes weaker with higher energy, and therefore an energy upgrade of the PS Booster to 2 GeV maximum beam energy is foreseen. As the PS Booster is with its 40 years already an old machine, the construction of a new accelerator, a Rapid Cycling Synchrotron (RCS), to replace the PS Booster has been proposed. In this thesis different options for the beam guidance in the RCS - referred to as lattice and optics - are studied, followed by a more general comparison of different lattices and optics and their performance under consideration of the space-charge effect. To further complement the LHC physics program, also the possibility of deep inelastic lepton-nucleon scattering at the LHC has been suggested, referred to as Large Hadron Electron Collider (LHeC). In this case the proton beam of the LHC collides with the electron beam, which is accelerated in a separate newly built machine. Two options are considered as electron accelerator: a new energy recovery linac - the Linac-Ring option - and the installation of an electron ring in the existing LHC tunnel - the Ring-Ring option. One of the main challenges of the Ring-Ring option is the integration of the electron ring in the current LHC tunnel. A layout, lattice and optics of the electron accelerator is developed in this thesis, which meets the requirements with regard to integration and reaches the beam parameters demanded by the particle physics experiments.

Design study of the large hadron electron collider and a rapid cycling synchrotron as alternative to the PS booster upgrade at CERN

Energy Technology Data Exchange (ETDEWEB)

Fitterer, Miriam

2013-02-22

With the Large Hadron Collider (LHC) the exploration of particle physics at center of mass energies at the TeV scale has begun. To extend the discovery potential of the LHC, a major upgrade is foreseen around 2020 of the LHC itself and the LHC injectors - the chain of accelerators preparing the beam for the LHC. One of the injectors - the second one in the chain - is the Proton Synchrotron (PS) Booster. Its performance is currently limited by the space-charge effect, which is the effect of the electromagnetic field of the particle beam on itself. This effect becomes weaker with higher energy, and therefore an energy upgrade of the PS Booster to 2 GeV maximum beam energy is foreseen. As the PS Booster is with its 40 years already an old machine, the construction of a new accelerator, a Rapid Cycling Synchrotron (RCS), to replace the PS Booster has been proposed. In this thesis different options for the beam guidance in the RCS - referred to as lattice and optics - are studied, followed by a more general comparison of different lattices and optics and their performance under consideration of the space-charge effect. To further complement the LHC physics program, also the possibility of deep inelastic lepton-nucleon scattering at the LHC has been suggested, referred to as Large Hadron Electron Collider (LHeC). In this case the proton beam of the LHC collides with the electron beam, which is accelerated in a separate newly built machine. Two options are considered as electron accelerator: a new energy recovery linac - the Linac-Ring option - and the installation of an electron ring in the existing LHC tunnel - the Ring-Ring option. One of the main challenges of the Ring-Ring option is the integration of the electron ring in the current LHC tunnel. A layout, lattice and optics of the electron accelerator is developed in this thesis, which meets the requirements with regard to integration and reaches the beam parameters demanded by the particle physics experiments.

Quantitative analysis of intraneuronal transport in human iPS neurons

Directory of Open Access Journals (Sweden)

Haruko Nakamura

2015-08-01

Full Text Available Induced pluripotent stem (iPS cells are promising tools to investigate disease mechanism and develop new drugs. Intraneuronal transport, which is fundamental for neuronal survival and function, is vulnerable to various pharmacological and chemical agents and is disrupted in some neurodegenerative disorders. We applied a quantification method for axonal transport by counting CM-DiI–labeled particles traveling along the neurite, which allowed us to monitor and quantitate, for the first time, intraneuronal transport in human neurons differentiated from iPS cells (iCell neurons. We evaluated the acute effects of several anti-neoplastic agents that have been previously shown to affect intraneuronal transport. Vincristine, paclitaxel and oxaliplatin decreased the number of moving particle along neurites. Cisplatin, however, produced no effect on intraneuronal transport, which is in contrast to our previous report indicating that it inhibits transport in chick dorsal root ganglion neurons. Our system may be a useful method for assessing intraneuronal transport and neurotoxicity in human iPS neurons.

Validity and reliability of the Dutch adaptation of the Psoriatic Arthritis Quality of Life (PsAQoL Questionnaire.

Directory of Open Access Journals (Sweden)

Freke Wink

Full Text Available OBJECTIVE: The Psoriatic Arthritis Quality of Life (PsAQoL questionnaire is a disease- specific instrument developed to measure quality of life (QoL in patients with psoriatic arthritis (PsA. The aim of this study was to translate the measure into Dutch and to determine its psychometric properties. METHOD: Translation of the original English PsAQoL into Dutch was performed by bilingual and lay panel. Ten field-test interviews with PsA patients were performed to assess face and content validity. In total, 211 PsA patients were included in a test-retest postal survey to investigate the reliability and construct validity of the Dutch adaptation of the PsAQoL. The PsAQoL, Health Assessment Questionnaire (HAQ and Skindex-17 were administered on two different occasions approximately two weeks apart. RESULTS: The Dutch version of the PsAQoL was found to be relevant, understandable and easy to complete in only a few minutes. It correlated as expected with the HAQ (Spearman's ρ = 0.72 and the 2 subscales of the Skindex-17 (ρ = 0.40 for the psychosocial and ρ = 0.46 for the symptom scale. Furthermore, the measure had good internal consistency (Cronbach's α = 0.92 and test-retest reliability (ρ = 0.89. The PsAQoL was able to define groups of patients based on self-reported general health status, self-reported severity of PsA and flare of arthritis. Duration of PsA did not influence PsAQoL scores. CONCLUSIONS: The Dutch version of the PsAQoL is a valid and reliable questionnaire suitable for use in clinical or research settings to asses PsA-specific QoL.

Marxism as permanent revolution

OpenAIRE

van Ree, E.

2013-01-01

This article argues that the 'permanent revolution' represented the dominant element in Karl Marx and Friedrich Engels' political discourse, and that it tended to overrule considerations encapsulated in 'historical materialism'. In Marx and Engels's understanding, permanent revolution did not represent a historical shortcut under exceptional circumstances, but the course revolutions in the modern era would normally take. Marx and Engels traced back the pattern to the sixteenth century. It is ...

Experiments at the KEK 12-GeV PS in 1991-1995

International Nuclear Information System (INIS)

Yoshimura, Y.

1994-06-01

This report has been edited mainly to introduce the various activities at the KEK 12-GeV PS. Chapter 1 is a list of experiments which have been approved by the PS-PAC since May 2, 1975. The machine time executed from FY 1990 to Fy 1993 is shown in chapter 2. In chapter 4, experiments which are currently in various stages of preparation, running and data analyzing are briefly described. The information was extracted from the 'KEK-PS Proposal', 'KEK Annual Report 1990-1993' and various published papers listed in chapter 5. In the descriptions the author sometimes might give 'sensitive' information concerning the experimental groups very directly. Readers of this publication are therefore requested not to directly quote the descriptions given in chapter 4. (J.P.N.)

Risk Management Capability Maturity and Performance of Complex Product and System (CoPS Projects with an Asian Perspective

Directory of Open Access Journals (Sweden)

Ren, Y.

2014-07-01

Full Text Available Complex Products and Systems (CoPS are high value, technology and engineering-intensive capital goods. The motivation of this study is the persistent high failure rate of CoPS projects, Asian CoPS provider’s weak capability and lack of specific research on CoPS risk management. This paper evaluates risk management maturity level of CoPS projects against a general CoPS risk management capability maturity model (RM-CMM developed by the authors. An Asian based survey was conducted to investigate the value of RM to project performance, and Asian (non-Japanese CoPS implementers’ perceived application of RM practices, their strengths and weaknesses. The survey result shows that higher RM maturity level leads to higher CoPS project performance. It also shows project complexity and uncertainty moderates the relationship between some RM practices and project performance, which implies that a contingency approach should be adopted to manage CoPS risks effectively. In addition, it shows that Asian CoPS implementers are weak in RM process and there are also rooms for improvement in the softer aspects of organizational capabilities and robustness.

Canadian Eskimo permanent tooth emergence timing.

Science.gov (United States)

Mayhall, J T; Belier, P L; Mayhall, M F

1978-08-01

To identify the times of emergence of the permanent teeth of Canadian Eskimos (Inuit), 368 children and adolescents were examined. The presence or absence of all permanent teeth except the third molars was recorded and these data subjected to probit analysis. Female emergence times were advanced over males. Generally, the Inuit of both sexes showed statistically significant earlier emergence times than Montreal children, except for the incisors. The present results do not support hypotheses indicating that premature extraction of the deciduous teeth advances the emergence of their succedaneous counterparts. There is some indication the controls of deciduous tooth emergence continue to play some part in emergence of the permanent dentition, especially the first permanent teeth that emerge.

13 CFR 120.900 - Sources of permanent financing.

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Sources of permanent financing... Development Company Loan Program (504) Permanent Financing § 120.900 Sources of permanent financing. Permanent financing for each Project must come from three sources: the Borrower's contribution, Third-Party Loans, and...

PsOr1, a potential target for RNA interference-based pest management.

Science.gov (United States)

Zhao, Y Y; Liu, F; Yang, G; You, M S

2011-02-01

Insect pests cause billions of dollars in agricultural losses, and attempts to kill them have resulted in growing threats from insecticide resistance, dietary pesticide pollution and environmental destruction. New approaches to control refractory insect pests are therefore needed. The host-plant preferences of insect pests rely on olfaction and are mediated via a seven transmembrane-domain odorant receptor (Or) family. The present study reports the cloning and characterization of PsOr1, the first candidate member of the Or gene family from Phyllotreta striolata, a devastating beetle pest that causes damage worldwide. PsOr1 is remarkably well conserved with respect to other insect orthologues, including DmOr83b from Drosophila melanogaster. These insect orthologues form an essential non-conventional Or sub-family and may play an important and generalized role in insect olfaction. We designed double-stranded (ds) RNA directly against the PsOr1 gene and exploited RNA interference (RNAi) to control P. striolata. The chemotactic behavioural measurements showed that adult beetles were unable to sense the attractant or repellent odour stimulus after microinjection of dsRNA against PsOr1. Reverse Transcription (RT)-PCR analysis showed specific down-regulation of mRNA transcript levels for this gene. Furthermore, host-plant preference experiments confirmed that silencing PsOr1 by RNAi treatment impaired the host-plant preferences of P. striolata for cruciferous vegetables. These results demonstrate that this insect control approach of using RNAi to target PsOr1 and its orthologues might be effective in blocking host-plant-seeking behaviours in diverse insect pests. The results also support the theory that this unique receptor type plays an essential general role in insect olfaction. © 2010 Fujian Agriculture and Forestry University. Insect Molecular Biology © 2010 The Royal Entomological Society.

[The Object Permanence Fallacy.] Commentary.

Science.gov (United States)

Bradley, Ben S.

1996-01-01

Suggests that Greenberg's challenge to the centrality of object permanence in developmental thinking reveals that developmentalists' theories about childhood speak about their own self-images. Notes that developmentalists have been guilty of not only the object permanence fallacy but also the genetic fallacy, or the mistaken belief that describing…

Effect of PS-K on long-term survival of primary lung cancer patients treated with radiation

International Nuclear Information System (INIS)

Okazaki, Atsushi; Nakajima, Nobuaki; Hayakawa, Kazushige; Saito, Yoshihiro; Mitomo, Osamu; Niibe, Hideo

1984-01-01

The effect of PS-K on long-term survival of primary lung cancer patients irradiated over 60 Gy through 1977 to 1982 was studied. PS-K was administrated orally 3.0 g, daily or intermittently in the pattern of 2 weeks per a month on patients of positive PPD skin test. All cases irradiated over 60 Gy were 174 (Group A) containing 62 cases with PS-K (Group B) and 112 cases without PS-K (Group C). Of group B, 44 cases were administrated within a month after curative irradiation (Group B1), 7 cases were administrated on time maintaining long-term good condition after irradiation (Group B2) and 11 cases were administrated after recognition of recurrence or metastasis (Group B3). Following results were obtained. 1. Obvious prolongation of survivals was recognized in the patients with PS-K after irradiation. (1) The cumulative 5 years survival rates of Group A, B 1 and C were 11.0%, 28.8% and 4.8%, respectively. (2) The cumulative 5 years survival rates of stage I,11 were 45.7% with PS-K and 10.7% without PS-K. (3) The cumulative 5 years survival rates of 21 cases matched age, sex, stage, histological type and tumor dose with and without PS-K were 37.8% and 7.2%. (4) In Group B 2, 5 cases out of 7 cases have been alived, but in Group B 3, satisfactory long-term survivals ware not obtained. 2. The necessary conditions which obtain long-term survival with PS-K were thought to be follows. One is that the tumor is brought almost to vanish by irradiation. Another is that the condition of host is superior to that of tumor in host-tumor relationship. 3. The possibility of intermittent administration of PS-K was suggested. (author)

Inhibition of Ps Formation in Benzene and Cyclohexane by CH3CI and CH3Br

DEFF Research Database (Denmark)

Wikander, G.; Mogensen, O. E.; Pedersen, Niels Jørgen

1983-01-01

Positron-annihilation lifetime spectra have been measured for mixtures of CH3Cl and CH3Br in cyclohexane and of CH3Cl in benzene. The ortho-positronium (Ps) yield decreased monotonically from 38% and 43% in cyclohexane and benzene respectively to 11% in pure CH3Cl and 6% in pure CH3Br. The strength......− anions to form Ps. while it forms a bound state with the halides. X−. CH3Cl was a roughly three times weaker Ps inhibitor in benzene than in cyclohexane, which shows that CH3Cl− does not dechlorinate in times comparable to or shorter than 400–500 ps in benzene. An improved model for the explanation of Ps...

75 FR 16748 - Final Voluntary Product Standard; DOC PS 20-10 “American Softwood Lumber Standard”

Science.gov (United States)

2010-04-02

...-0146-02] Final Voluntary Product Standard; DOC PS 20-10 ``American Softwood Lumber Standard'' AGENCY... of Standards and Technology (NIST) announces voluntary product standard DOC PS 20-10 ``American Softwood Lumber Standard'' which will supersede DOC PS 20-05. The Standard establishes standard sizes and...

Transmissão psíquica entre as gerações

Directory of Open Access Journals (Sweden)

Olga B. Ruiz Correa

2003-01-01

Full Text Available O reconhecimento da alienação da subjetividade, comprometida numa transmissão psíquica geracional defeituosa, possibilita um novo olhar clínico sobre as patologias da modernidade. O vínculo mãe-bebê e o grupo familiar constituem o berço psíquico do sujeito, constituído por uma tecelagem grupal geracional que poderíamos denominar arquivos de família. Os processos de transmissão são sustentados por mecanismos de identificação junto a um interjogo de projeções-introjeções e incorporações, assim como por uma referência ao superego parental. Neste espaço psíquico intersubjetivo se processa a transmissão psíquica geracional, que precisa ser metabolizada e sofrer transformações. Na clínica do grupo familiar são considerados os traços traumáticos e feridas narcisistas que são transmitidos como restos do "negativo", sem modificação e de forma repetitiva, nos persos vínculos do espaço grupal-familiar, gerando, assim, persos sintomas e sofrimento intra e intersubjetivo.

Topology optimized permanent magnet systems

Science.gov (United States)

Bjørk, R.; Bahl, C. R. H.; Insinga, A. R.

2017-09-01

Topology optimization of permanent magnet systems consisting of permanent magnets, high permeability iron and air is presented. An implementation of topology optimization for magnetostatics is discussed and three examples are considered. The Halbach cylinder is topology optimized with iron and an increase of 15% in magnetic efficiency is shown. A topology optimized structure to concentrate a homogeneous field is shown to increase the magnitude of the field by 111%. Finally, a permanent magnet with alternating high and low field regions is topology optimized and a Λcool figure of merit of 0.472 is reached, which is an increase of 100% compared to a previous optimized design.

Teaching Object Permanence: An Action Research Study

Science.gov (United States)

Bruce, Susan M.; Vargas, Claudia

2013-01-01

"Object permanence," also known as "object concept" in the field of visual impairment, is one of the most important early developmental milestones. The achievement of object permanence is associated with the onset of representational thought and language. Object permanence is important to orientation, including the recognition of landmarks.…

Preliminary evaluation of PS300: A new self-lubricating high temperature composite coating for use to 800{degrees}C

Energy Technology Data Exchange (ETDEWEB)

DellaCorte, C.; Edmonds, B.J.

1996-12-31

This paper introduces PS300, a plasma sprayed, self-lubricating composite coating for use in sliding contacts at temperatures to 800{degrees}C. PS300 is a metal bonded chrome oxide coating with silver and BaF{sub 2}/CaF{sub 2} eutectic solid lubricant additives. PS300 is similar to PS200, a chromium carbide based coating; which is currently being investigated for a variety of tribological applications. In pin-on-disk testing up to 650{degrees}C, PS300 exhibited comparable friction and wear properties to PS200. The PS300 matrix, which is predominantly chromium oxide rather than chromium carbide, does not require diamond grinding and polishes readily with silicon carbide abrasives greatly reducing manufacturing costs compared to PS200. It is anticipated that PS300 has potential for sliding bearing and seal applications in both aerospace and general industry.

File list: NoD.PSC.05.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available NoD.PSC.05.AllAg.iPS_derived_neural_cells hg19 No description Pluripotent stem cell iPS derived neural... cells http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/NoD.PSC.05.AllAg.iPS_derived_neural_cells.bed ...

Nouvelle application de control des cavités 200 MHz RF du PS (CERN)

CERN Document Server

Cotte, D

2011-01-01

Le système Radio Fréquence (RF) 200MHz du PS est un outil essentiel pour la préparation des faisceaux haute intensité du PS. Dans l’anneau PS on trouve 6 cavités 200 MHz utilisées pour contrôler : • l’émittance longitudinale des « bunches » • le processus de « Rebunching » du faisceau avant de l’envoyer au SPS. Chaque cavité est pilotée par des événements appelés « timing » et suit une fonction de tension programmée. Cependant, l’électronique utilisée pour piloter les cavités 200 MHz du PS est obsolète et sa fiabilité non garantie pour cause du manque de pièces de rechange. Ce document décrit le fonctionnement du nouveau programme d’application qui fait abstraction de l’ancienne matrice hardware. Elle suit les recommandations décrites dans l’étude d’une nouvelle structure pour le système RF 200MHz du PS. [1

Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells

Energy Technology Data Exchange (ETDEWEB)

Kinoshita, Taisuke [Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo 160-8582 (Japan); Nagamatsu, Go, E-mail: gonag@sc.itc.keio.ac.jp [Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo 160-8582 (Japan); Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012 (Japan); Kosaka, Takeo [Department of Urology, School of Medicine, Keio University, Tokyo 160-8582 (Japan); Takubo, Keiyo [Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo 160-8582 (Japan); Hotta, Akitsu [Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012 (Japan); Department of Reprogramming Science, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto (Japan); Ellis, James [Ontario Human iPS Cell Facility, Molecular Genetics, University of Toronto, Developmental and Stem Cell Biology, SickKids, Toronto, Canada MG1L7 (Canada); Suda, Toshio, E-mail: sudato@sc.itc.keio.ac.jp [Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo 160-8582 (Japan)

2011-04-08

Highlights: {yields} iPS cells were induced with a fluorescence monitoring system. {yields} ATM-deficient tail-tip fibroblasts exhibited quite a low reprogramming efficiency. {yields} iPS cells obtained from ATM-deficient cells had pluripotent cell characteristics. {yields} ATM-deficient iPS cells had abnormal chromosomes, which were accumulated in culture. -- Abstract: During cell division, one of the major features of somatic cell reprogramming by defined factors, cells are potentially exposed to DNA damage. Inactivation of the tumor suppressor gene p53 raised reprogramming efficiency but resulted in an increased number of abnormal chromosomes in established iPS cells. Ataxia-telangiectasia mutated (ATM), which is critical in the cellular response to DNA double-strand breaks, may also play an important role during reprogramming. To clarify the function of ATM in somatic cell reprogramming, we investigated reprogramming in ATM-deficient (ATM-KO) tail-tip fibroblasts (TTFs). Although reprogramming efficiency was greatly reduced in ATM-KO TTFs, ATM-KO iPS cells were successfully generated and showed the same proliferation activity as WT iPS cells. ATM-KO iPS cells had a gene expression profile similar to ES cells and WT iPS cells, and had the capacity to differentiate into all three germ layers. On the other hand, ATM-KO iPS cells accumulated abnormal genome structures upon continuous passages. Even with the abnormal karyotype, ATM-KO iPS cells retained pluripotent cell characteristics for at least 20 passages. These data indicate that ATM does participate in the reprogramming process, although its role is not essential.

Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells

International Nuclear Information System (INIS)

Kinoshita, Taisuke; Nagamatsu, Go; Kosaka, Takeo; Takubo, Keiyo; Hotta, Akitsu; Ellis, James; Suda, Toshio

2011-01-01

Highlights: → iPS cells were induced with a fluorescence monitoring system. → ATM-deficient tail-tip fibroblasts exhibited quite a low reprogramming efficiency. → iPS cells obtained from ATM-deficient cells had pluripotent cell characteristics. → ATM-deficient iPS cells had abnormal chromosomes, which were accumulated in culture. -- Abstract: During cell division, one of the major features of somatic cell reprogramming by defined factors, cells are potentially exposed to DNA damage. Inactivation of the tumor suppressor gene p53 raised reprogramming efficiency but resulted in an increased number of abnormal chromosomes in established iPS cells. Ataxia-telangiectasia mutated (ATM), which is critical in the cellular response to DNA double-strand breaks, may also play an important role during reprogramming. To clarify the function of ATM in somatic cell reprogramming, we investigated reprogramming in ATM-deficient (ATM-KO) tail-tip fibroblasts (TTFs). Although reprogramming efficiency was greatly reduced in ATM-KO TTFs, ATM-KO iPS cells were successfully generated and showed the same proliferation activity as WT iPS cells. ATM-KO iPS cells had a gene expression profile similar to ES cells and WT iPS cells, and had the capacity to differentiate into all three germ layers. On the other hand, ATM-KO iPS cells accumulated abnormal genome structures upon continuous passages. Even with the abnormal karyotype, ATM-KO iPS cells retained pluripotent cell characteristics for at least 20 passages. These data indicate that ATM does participate in the reprogramming process, although its role is not essential.

Intrusive luxation of 60 permanent incisors

DEFF Research Database (Denmark)

Tsilingaridis, Georgios; Malmgren, Barbro; Andreasen, Jens O

2012-01-01

  Intrusive luxation in the permanent dentition is an uncommon injury but it is considered one of the most severe types of dental trauma because of the risk for damage to the periodontal ligament, pulp and alveolar bone. Management of intrusive luxation in the permanent dentition is controversial....... The purpose of this study was to evaluate pulp survival and periodontal healing in intrusive luxated permanent teeth in relation to treatment alternatives, degree of intrusion and root development....

Permanent magnet materials and their application

International Nuclear Information System (INIS)

Campbell, P.

1994-01-01

Permanent magnets are of great industrial importance in industrial drives, consumer products, computers, and automobiles. Since 1970, new classes of magnet materials have been developed. This book reviews the older and newer materials and is presented as a comprehensive design text for permanent magnets and their applications. After an initial chapter on the fundamentals of magnetism, the author discusses magnetic physics considerations specific to permanent magnets and describes the fabrications and characteristics of commercial materials: alnico, samarium-cobalt, ferrite, and neodymium-iron-boron. Thermal stability, magnet design procedures, magnetic field analysis methods, and measurement methods are discussed in subsequent chapters, followed by a concluding chapter reviewing commercial and industrial products that use permanent magnets. The chapter on thermal properties of magnet materials is of particular interest, bringing together information not readily found elsewhere. The review of applications is also deserving of attention, specifically the sections on motors and actuators. Although particle accelerator applications are discussed, the use of permanent magnet sextuples in modern ECR ion sources is not mentioned

File list: InP.PSC.20.AllAg.iPS_derived_neural_cells [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available InP.PSC.20.AllAg.iPS_derived_neural_cells hg19 Input control Pluripotent stem cell iPS derived neural... cells SRX702550 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/InP.PSC.20.AllAg.iPS_derived_neural_cells.bed ...

Performance of a dual-process PVD/PS tungsten coating structure under deuterium ion irradiation

Energy Technology Data Exchange (ETDEWEB)

Kim, Hyunmyung; Lee, Ho Jung; Kim, Sung Hwan [Department of Nuclear and Quantum Engineering, KAIST, Daejeon (Korea, Republic of); Song, Jae-Min [Department of Nuclear Engineering, Seoul National University, Seoul (Korea, Republic of); Jang, Changheui, E-mail: chjang@kaist.ac.kr [Department of Nuclear and Quantum Engineering, KAIST, Daejeon (Korea, Republic of)

2016-11-01

Highlights: • D{sup +} irradiation performance of a dual-process PVD/PS W coating was evaluated. • Low-energy plasmas exposure of 100 eV D{sup +} with 1.17 × 10{sup 21} D/s{sup −1} m{sup 2} flux was applied. • After D ion irradiation, flakes were observed on the surface of the simple PS coating. • While, sub-μm size protrusions were observed for dual-process PVD/PS W coating. • Height of D spike in depth profile was lower for dual-process PVD/PS W coating. - Abstract: A dual-process coating structure was developed on a graphite substrate to improve the performance of the coating structure under anticipated operating condition of fusion devices. A thin multilayer W/Mo coating (6 μm) was deposited by physical vapor deposition (PVD) method with a variation of Mo interlayer thickness on plasma spray (PS) W coating (160 μm) of a graphite substrate panel. The dual-process PVD/PS W coatings then were exposed to 3.08 × 10{sup 24} D m{sup −2} of 100 eV D ions with a flux of 1.71 × 10{sup 21} D m{sup −2} s{sup −1} in an electron cyclotron resonance (ECR) chamber. After irradiation, surface morphology and D depth profiles of the dual-process coating were analyzed and compared to those of the simple PS W coating. Both changes in surface morphology and D retention were strongly dependent on the microstructure of surface coating. Meanwhile, the existence of Mo interlayer seemed to have no significant effect on the retention of deuterium.

SU-F-BRD-12: When Does Pencil Beam Scanning Become Superior to Passive Scattered Proton Therapy for Pediatric Head and Neck Cancers?

Energy Technology Data Exchange (ETDEWEB)

Moteabbed, M; Depauw, N; Kooy, H; Yock, T; Paganetti, H [Massachusetts General Hospital, Boston, MA (United States)

2015-06-15

Purpose: To investigate the dosimetric benefits of pencil beam scanning (PBS) compared with passive scattered (PS) proton therapy for treatment of pediatric head&neck patients as a function of the PBS spot size and explore the advantages of using apertures in PBS. Methods: Ten pediatric patients with head&neck cancers treated by PS proton therapy at our institution were retrospectively selected. The histologies included rhabdomyosarcoma, ependymoma, astrocytoma, craniopharyngioma and germinoma. The prescribed dose ranged from 36 to 54 Gy(RBE). Five PBS plans were created for each patient using variable spot size (average sigma at isocenter) and choice of beam specific apertures: (1) 10mm spots, (2) 10mm spots with apertures, (3) 6mm spots, (4) 6mm spots with apertures, and (5) 3mm spots. The plans were optimized for intensity modulated proton therapy (IMPT) with no single beam uniformity constraints. Dose volume indices as well as equivalent uniform dose (EUD) were compared between PS and PBS plans. Results: Although target coverage was clinically adequate for all cases, the plans with largest (10mm) spots provide inferior quality compared with PS in terms of dose to organs-at-risk (OAR). However, adding apertures to these plans ensured lower OAR dose than PS. The average EUD difference between PBS and PS plans over all patients and organs at risk were (1) 2.5%, (2) −5.1%, (3) -5%, (4) −7.8%, and (5) −9.5%. As the spot size decreased, more conformal plans were achieved that offered similar target coverage but lower dose to the neighboring healthy organs, while alleviating the need for using apertures. Conclusion: The application of PBS does not always translate to better plan qualities compared to PS depending on the available beam spot size. We recommend that institutions with spot size larger than ∼6mm at isocenter consider using apertures to guarantee clinically comparable or superior dosimetric efficacy to PS treatments.

80 kV electrostatic wire septum for AmPS

International Nuclear Information System (INIS)

Linden, A. van der; Bijleveld, J.H.M.; Rookhuizen, H.B.; Bruinsma, P.J.T.; Heine, E.; Lassing, P.; Prins, E.

1992-01-01

The Amsterdam Pulse Stretcher (AmPS) ring aims at a 100% duty cycle operation by means of slow extraction of injected electron beam pulses of 2.1 μs. In the extraction process of the AmPS, the extracted beam is intercepted from the circulating beam by the 1 m long electrostatic wire septum. For a bending angle of 4.4 mrad the maximum anode voltage is 80 kV. Care has been given to the electric field distribution at the entrance and exit of the septum and to the insulators, required to support the anode. Prototype tests have been successful up to an anode voltage of 120 kV. (R.P.) 9 refs.; 5 figs

Minor psychiatric disorders among nurses university faculties Disturbios psíquicos menores en enfermeros docentes universitarios Distúrbios psíquicos menores em enfermeiros docentes de universidades

Directory of Open Access Journals (Sweden)

Juliana Petri Tavares

2012-02-01

Full Text Available This cross-sectional study addresses 130 nursing faculty members in federal universities from Rio Grande do Sul, Brazil. It investigated the psychological demands and decision latitude (the Demand-Control Model by Karasek and their association with Minor Psychological Disorders (MPDs. The Brazilian versions of the Self-Report-Questionnaire-20 and the Job Stress Scale were used. MPDs were prevalent in 20% of the studied individuals. After adjusting for potential confounders, the chances of participants presenting mental disorders were higher in the quadrant 'active strain jobs' (OR=14.23, 95% CI 1.55 to 130.73, followed by the 'high strain jobs' quadrant (OR=10.05, 95% CI 1.23 to 82.44, compared to nursing professors classified in the 'low strain jobs' quadrant. We conclude that high psychological demands and low control over work can cause disorders in nursing professors, among them, MPDs.Estudio epidemiológico seccional entre 130 enfermeros docentes de las universidades federales del estado de Rio Grande do Sul, en Brasil, que tuvo como objetivo investigar la demanda psicológica y el control del trabajo (Modelo Demanda-Control de Karasek y sus asociaciones con Disturbios Psíquicos Menores. Se utilizaron las versiones brasileñas del Self-Report-Questionnaire-20 y del Job Stress Scale. La prevalencia de Disturbios Psíquicos Menores fue del 20,1%. Después de ajustar los posibles factores de confusión, las posibilidades de trastornos psíquicos fueron mayores en el cuadrante Trabajo Activo (OR=14,13; IC95%=1,55-130,73, seguido del cuadrante Alta exigencia (OR=10,05; IC95%=1,23-82,44, en comparación con los enfermeros docentes del cuadrante Baja Exigencia. Se concluyó que la alta demanda psicológica y el bajo control del trabajo pueden provocar daños a la salud, entre ellos los Disturbios Psíquicos Menores en enfermeros docentes.Trata-se de estudo epidemiológico seccional, incluindo 130 enfermeiros docentes das Universidades Federais do

High-energy electron irradiation of NdFeB permanent magnets: Dependence of radiation damage on the electron energy

Energy Technology Data Exchange (ETDEWEB)

Bizen, Teruhiko [JASRI SPring-8, 1-1-1 Kouto Sayo-cho, Sayo-gun, Hyogo 679-5198 (Japan)]. E-mail: bizen@spring8.or.jp; Asano, Yoshihiro [JASRI SPring-8, 1-1-1 Kouto Sayo-cho, Sayo-gun, Hyogo 679-5198 (Japan); RIKEN SPring-8 Center, 1-1-1 Kouto Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan); Marechal, Xavier-Marie [JASRI SPring-8, 1-1-1 Kouto Sayo-cho, Sayo-gun, Hyogo 679-5198 (Japan); Seike, Takamitsu [JASRI SPring-8, 1-1-1 Kouto Sayo-cho, Sayo-gun, Hyogo 679-5198 (Japan); Aoki, Tsuyoshi [JASRI SPring-8, 1-1-1 Kouto Sayo-cho, Sayo-gun, Hyogo 679-5198 (Japan); Fukami, Kenji [JASRI SPring-8, 1-1-1 Kouto Sayo-cho, Sayo-gun, Hyogo 679-5198 (Japan); Hosoda, Naoyasu [JASRI SPring-8, 1-1-1 Kouto Sayo-cho, Sayo-gun, Hyogo 679-5198 (Japan); Yonehara, Hiroto [JASRI SPring-8, 1-1-1 Kouto Sayo-cho, Sayo-gun, Hyogo 679-5198 (Japan); Takagi, Tetsuya [JASRI SPring-8, 1-1-1 Kouto Sayo-cho, Sayo-gun, Hyogo 679-5198 (Japan); Hara, Toru [RIKEN SPring-8 Center, 1-1-1 Kouto Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan); Tanaka, Takashi [RIKEN SPring-8 Center, 1-1-1 Kouto Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan); Kitamura, Hideo [RIKEN SPring-8 Center, 1-1-1 Kouto Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan)

2007-05-11

High-energy electron-beam bombardment of Nd{sub 2}Fe{sub 14}B-type permanent magnets induces radiation damage characterized by a drop in the magnetic field. Experiments carried out at the SPring-8 booster synchrotron, with 4, 6, and 8 GeV electrons, show that the drop in magnetic field is energy dependent. Electromagnetic shower simulations suggest that most of the radiation damage happens in a small region around the irradiation axis, and that the contribution of neutrons with large scattering angles or with low energies to the magnetic field change is small.

High-energy electron irradiation of NdFeB permanent magnets: Dependence of radiation damage on the electron energy

International Nuclear Information System (INIS)

Bizen, Teruhiko; Asano, Yoshihiro; Marechal, Xavier-Marie; Seike, Takamitsu; Aoki, Tsuyoshi; Fukami, Kenji; Hosoda, Naoyasu; Yonehara, Hiroto; Takagi, Tetsuya; Hara, Toru; Tanaka, Takashi; Kitamura, Hideo

2007-01-01

High-energy electron-beam bombardment of Nd 2 Fe 14 B-type permanent magnets induces radiation damage characterized by a drop in the magnetic field. Experiments carried out at the SPring-8 booster synchrotron, with 4, 6, and 8 GeV electrons, show that the drop in magnetic field is energy dependent. Electromagnetic shower simulations suggest that most of the radiation damage happens in a small region around the irradiation axis, and that the contribution of neutrons with large scattering angles or with low energies to the magnetic field change is small

Hydrogen peroxide modulates energy metabolism and oxidative stress in cultures of permanent human Müller cells MIO-M1.

Science.gov (United States)

Peters, Sven; Griebsch, Max; Klemm, Matthias; Haueisen, Jens; Hammer, Martin

2017-09-01

In this study the influence of hydrogen peroxide (H 2 O 2 ) on the redox state, NADH protein binding, and mitochondrial membrane potential in Müller cells is investigated. Cultures of permanent human Müller cells MIO-M1 were exposed to H 2 O 2 in 75 µM and 150 µM concentration for two hours. Fluorescence emission spectra and lifetimes were measured by two-photon microscopy (excitation wavelength: 740 nm) at the mitochondria which were identified in the microscopic images by their fluorescence properties (spectra and intensity). Two hours of H 2 O 2 exposure did not impair viability of MIO-M1 cells in culture. Whereas the ratio of flavine- to NADH fluorescence intensity did not change under either H 2 O 2 concentration, the mean lifetime was significantly different between controls, not exposed to H 2 O 2 , and the 150 µM H 2 O 2 exposure (972 ± 63 ps vs. 1152 ± 64 ps, p = 0.014). One hour after cessation of the H 2 O 2 exposure, the value retuned to that of the control (983 ± 36 ps). A hyperpolarization of the mitochondrial membrane under 150 µM H 2 O 2 was found. These findings suggest a shift form free to protein-bound NADH in mitochondria as well as a hyperpolarization of their inner membrane which could be related to an impairment of Müller cell function despite their preserved viability. Exposure of human Müller cells to hydrogen peroxide for two hours results in a reversible change of protein binding of mitochondrial NADH upon unchanged redox ratio. The mitochondrial membrane potential is increased during exposure. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

The chitinase C gene PsChiC from Pseudomonas sp. and its synergistic effects on larvicidal activity

Directory of Open Access Journals (Sweden)

Wanfang Zhong

2015-09-01

Full Text Available Pseudomonas sp. strain TXG6-1, a chitinolytic gram-negative bacterium, was isolated from a vegetable field in Taixing city, Jiangsu Province, China. In this study, a Pseudomonas chitinase C gene (PsChiC was isolated from the chromosomal DNA of this bacterium using a pair of specific primers. The PsChiC gene consisted of an open reading frame of 1443 nucleotides and encoded 480 amino acid residues with a calculated molecular mass of 51.66 kDa. The deduced PsChiC amino acid sequence lacked a signal sequence and consisted of a glycoside hydrolase family 18 catalytic domain responsible for chitinase activity, a fibronectin type III-like domain (FLD and a C-terminal chitin-binding domain (ChBD. The amino acid sequence of PsChiCshowed high sequence homology (> 95% with chitinase C from Serratia marcescens. SDS-PAGE showed that the molecular mass of chitinase PsChiC was 52 kDa. Chitinase assays revealed that the chitobiosidase and endochitinase activities of PsChiCwere 51.6- and 84.1-fold higher than those of pET30a, respectively. Although PsChiC showed little insecticidal activity towards Spodoptera litura larvae, an insecticidal assay indicated that PsChiC increased the insecticidal toxicity of SpltNPV by 1.78-fold at 192 h and hastened death. These results suggest that PsChiC from Pseudomonas sp. could be useful in improving the pathogenicity of baculoviruses.

Well-oriented ZZ–PS-tag with high Fc-binding onto polystyrene surface for controlled immobilization of capture antibodies

International Nuclear Information System (INIS)

Tang, Jin-Bao; Sun, Xi-Feng; Yang, Hong-Ming; Zhang, Bao-Gang; Li, Zhi-Jian; Lin, Zhi-Juan; Gao, Zhi-Qin

2013-01-01

Graphical abstract: -- Highlights: •A versatile platform for immobilizing functionally intact IgG is proposed. •The mechanism relies on properly oriented ZZ–PS-tag onto a hydrophilic PS surface. •The oriented ZZ–PS-tag presents ∼fivefold higher IgG-binding activity. •The platform shows tenfold higher sensitivity and a wider linear range in ELISA. -- Abstract: The site specificity and bioactivity retention of antibodies immobilized on a solid substrate are crucial requirements for solid phase immunoassays. A fusion protein between an immunoglobulin G (IgG)-binding protein (ZZ protein) and a polystyrene-binding peptide (PS-tag) was constructed, and then used to develop a simple method for the oriented immobilization of the ZZ protein onto a PS support by the specific attachment of the PS-tag onto a hydrophilic PS. The orientation of intact IgG was achieved via the interaction of the ZZ protein and the constant fragment (Fc), thereby displayed the Fab fragment for binding antigen. The interaction between rabbit IgG anti-horseradish peroxidase (anti-HRP) and its binding partner HRP was analyzed. Results showed that the oriented ZZ–PS-tag yielded an IgG-binding activity that is fivefold higher than that produced by the passive immobilization of the ZZ protein. The advantage of the proposed immunoassay strategy was demonstrated through an enzyme-linked immunosorbent assay, in which monoclonal mouse anti-goat IgG and HRP-conjugated rabbit F(ab′) 2 anti-goat IgG were used to detect goat IgG. The ZZ–PS-tag presented a tenfold higher sensitivity and a wider linear range than did the passively immobilized ZZ protein. The proposed approach may be an attractive strategy for a broad range of applications involving the oriented immobilization of intact IgGs onto PS supports, in which only one type of phi-PS (ZZ–PS-tag) surface is used

Well-oriented ZZ–PS-tag with high Fc-binding onto polystyrene surface for controlled immobilization of capture antibodies

Energy Technology Data Exchange (ETDEWEB)

Tang, Jin-Bao, E-mail: tangjinbao@yahoo.com.cn [School of Pharmacy and Biology, Weifang Medical University, Weifang 261053 (China); Sun, Xi-Feng [Clinical Laboratory, Weifang People' s Hospital, Weifang 261041 (China); Yang, Hong-Ming [School of Pharmacy and Biology, Weifang Medical University, Weifang 261053 (China); Zhang, Bao-Gang [School of Basic Medicine, Weifang Medical University, Weifang 261053 (China); Li, Zhi-Jian [School of Pharmacy and Biology, Weifang Medical University, Weifang 261053 (China); Lin, Zhi-Juan [School of Basic Medicine, Weifang Medical University, Weifang 261053 (China); Gao, Zhi-Qin, E-mail: zhiqingao@yahoo.cn [School of Pharmacy and Biology, Weifang Medical University, Weifang 261053 (China)

2013-05-07

Graphical abstract: -- Highlights: •A versatile platform for immobilizing functionally intact IgG is proposed. •The mechanism relies on properly oriented ZZ–PS-tag onto a hydrophilic PS surface. •The oriented ZZ–PS-tag presents ∼fivefold higher IgG-binding activity. •The platform shows tenfold higher sensitivity and a wider linear range in ELISA. -- Abstract: The site specificity and bioactivity retention of antibodies immobilized on a solid substrate are crucial requirements for solid phase immunoassays. A fusion protein between an immunoglobulin G (IgG)-binding protein (ZZ protein) and a polystyrene-binding peptide (PS-tag) was constructed, and then used to develop a simple method for the oriented immobilization of the ZZ protein onto a PS support by the specific attachment of the PS-tag onto a hydrophilic PS. The orientation of intact IgG was achieved via the interaction of the ZZ protein and the constant fragment (Fc), thereby displayed the Fab fragment for binding antigen. The interaction between rabbit IgG anti-horseradish peroxidase (anti-HRP) and its binding partner HRP was analyzed. Results showed that the oriented ZZ–PS-tag yielded an IgG-binding activity that is fivefold higher than that produced by the passive immobilization of the ZZ protein. The advantage of the proposed immunoassay strategy was demonstrated through an enzyme-linked immunosorbent assay, in which monoclonal mouse anti-goat IgG and HRP-conjugated rabbit F(ab′){sub 2} anti-goat IgG were used to detect goat IgG. The ZZ–PS-tag presented a tenfold higher sensitivity and a wider linear range than did the passively immobilized ZZ protein. The proposed approach may be an attractive strategy for a broad range of applications involving the oriented immobilization of intact IgGs onto PS supports, in which only one type of phi-PS (ZZ–PS-tag) surface is used.

Beyond PSInSAR: the SQUEESAR Approach

Science.gov (United States)

Ferretti, A.; Novali, F.; Fumagalli, A.; Prati, C.; Rocca, F.; Rucci, A.

2009-12-01

After a decade since the first results on ERS data, Permanent Scatterer (PS) InSAR has become an operational technology for detecting and monitoring slow surface deformation phenomena such as subsidence and uplift, landslides, seismic fault creeping, volcanic inflation, etc. Processing procedures have been continuously updated, but the core of the algorithm has not been changed significantly. As well known, in PSInSAR, the main target is the identification of individual pixels that exhibit a “PS behavior”, i.e. they are only slightly affected by both temporal and geometrical decorrelation. Typically, these scatterers correspond to man-made objects, but PS have been identified also in non-urban areas, where exposed rocks or outcrops can indeed create good radar benchmarks and enable high-quality displacement measurements. Contrary to interferogram stacking techniques, PS analyses are carried out on a pixel-by-pixel basis, with no filtering of the interferograms, in order to preserve phase values from possible incoherent clutter surrounding good radar targets. In fact, any filtering process implies a spatial smoothing of the data that could compromise - rather than improve - phase coherence, at least for isolated PS. Although the PS approach usually allows one to retrieve high quality deformation measurements on a sparse grid of good radar targets, in some datasets it is quite evident how the number of pixels where some information can be extracted could be significantly increased by relaxing the hypothesis on target coherence and searching for pixels where the coherence level is high enough at least in some interferograms of the data-stack, not necessarily all. The idea of computing a “coherence matrix” for each pixel of the area of interest have been already proposed in previous papers, together with a statistical estimation of some physical parameters of interest (e.g. the average displacement rate) based on the covariance matrix. In past publications

Package-friendly piezoresistive pressure sensors with on-chip integrated packaging-stress-suppressed suspension (PS3) technology

International Nuclear Information System (INIS)

Wang, Jiachou; Li, Xinxin

2013-01-01

An on-chip integrated packaging-stress-suppressed suspension (PS 3 ) technology for a packaging-stress-free pressure sensor is proposed and developed. With a MIS (microholes interetch and sealing) micromachining process implemented only from the front-side of a single-side polished (1 1 1) silicon wafer, a compact cantilever-shaped PS 3 is on-chip integrated surrounding a piezoresistive pressure-sensing structure to provide a packaging-process/substrate-friendly method for low-cost but high-performance sensor applications. With the MIS process, the chip size of the PS 3 -enclosed pressure sensor is as small as 0.8 mm × 0.8 mm. Compared with a normal pressure sensor without PS 3 (but with an identical pressure-sensing structure), the proposed pressure sensor has the same sensitivity of 0.046 mV kPa −1 (3.3 V) −1 . However, without using the thermal compensation technique, a temperature coefficient of offset of only 0.016% °C −1 FS is noted for the sensor with PS 3 , which is about 15 times better than that for the sensor without PS 3 . Featuring effective isolation and elimination of the influence from packaging stress, the PS 3 technique is promising to be widely used for packaging-friendly mechanical sensors. (paper)

Successful online learning the five Ps

OpenAIRE

Jim FLOOD

2004-01-01

Successful online learning the five Ps Jim FLOOD E-learning Consultant-UK Key learning points An important aspect of design for online learning is visual ergonomics. Learning theories offer poor predictive power in terms of how learners work and learn. Success at learning is closely related to emotional engagementand learning designers tend to ignore this aspect. Online learning poses a challenging experience for learnersand they need support t...

An elementary presentation of the PS ''beam control'' system

International Nuclear Information System (INIS)

Boussard, D.

1973-01-01

The PS synchrotron control system is explained in general terms, covering the topics of frequency control, beam transfer, damping, stability, conservation of longitudinal emittance, and second order problems

A Myb transcription factor of Phytophthora sojae, regulated by MAP kinase PsSAK1, is required for zoospore development.

Directory of Open Access Journals (Sweden)

Meng Zhang

Full Text Available PsSAK1, a mitogen-activated protein (MAP kinase from Phytophthora sojae, plays an important role in host infection and zoospore viability. However, the downstream mechanism of PsSAK1 remains unclear. In this study, the 3'-tag digital gene expression (DGE profiling method was applied to sequence the global transcriptional sequence of PsSAK1-silenced mutants during the cysts stage and 1.5 h after inoculation onto susceptible soybean leaf tissues. Compared with the gene expression levels of the recipient P. sojae strain, several candidates of Myb family were differentially expressed (up or down in response to the loss of PsSAK1, including of a R2R3-type Myb transcription factor, PsMYB1. qRT-PCR indicated that the transcriptional level of PsMYB1 decreased due to PsSAK1 silencing. The transcriptional level of PsMYB1 increased during sporulating hyphae, in germinated cysts, and early infection. Silencing of PsMYB1 results in three phenotypes: a no cleavage of the cytoplasm into uninucleate zoospores or release of normal zoospores, b direct germination of sporangia, and c afunction in zoospore-mediated plant infection. Our data indicate that the PsMYB1 transcription factor functions downstream of MAP kinase PsSAK1 and is required for zoospore development of P. sojae.

psRNATarget: a plant small RNA target analysis server (2017 release).

Science.gov (United States)

Dai, Xinbin; Zhuang, Zhaohong; Zhao, Patrick Xuechun

2018-04-30

Plant regulatory small RNAs (sRNAs), which include most microRNAs (miRNAs) and a subset of small interfering RNAs (siRNAs), such as the phased siRNAs (phasiRNAs), play important roles in regulating gene expression. Although generated from genetically distinct biogenesis pathways, these regulatory sRNAs share the same mechanisms for post-translational gene silencing and translational inhibition. psRNATarget was developed to identify plant sRNA targets by (i) analyzing complementary matching between the sRNA sequence and target mRNA sequence using a predefined scoring schema and (ii) by evaluating target site accessibility. This update enhances its analytical performance by developing a new scoring schema that is capable of discovering miRNA-mRNA interactions at higher 'recall rates' without significantly increasing total prediction output. The scoring procedure is customizable for the users to search both canonical and non-canonical targets. This update also enables transmitting and analyzing 'big' data empowered by (a) the implementation of multi-threading chunked file uploading, which can be paused and resumed, using HTML5 APIs and (b) the allocation of significantly more computing nodes to its back-end Linux cluster. The updated psRNATarget server has clear, compelling and user-friendly interfaces that enhance user experiences and present data clearly and concisely. The psRNATarget is freely available at http://plantgrn.noble.org/psRNATarget/.

Experiments at the 12 GeV PS in 1986 - 1990

International Nuclear Information System (INIS)

Yoshimura, Y.

1990-12-01

This book has been edited mainly to introduce the various activities at the KEK 12 GeV PS. In the chapter 4, experiments which are currently in the stages of preparation, running and data analyzing are briefly described using information extracted from the 'KEK PS Proposal', 'KEK Annual Report 1986-1989' and various published papers listed in chapter 5. In the descriptions the author sometimes gives 'sensitive' information concerning the experimental groups very directly. Readers of this publication are therefore requested not to directly quote the descriptions given in chapter 4 (since that information was not provided by them). (author)

Inauguration of POPS: the new power system of the PS

CERN Multimedia

Maximilien Brice

2010-01-01

Pictures 03 and 04 : The team from the Electrical Power Converters Group (TE/EPC) is joined by the Director of Accelerators, the heads of the BE, TE and FI departments, CERN managers and Converteam representatives in a group portrait in front of three of the containers that house the capacitor banks of the PS's new power supply system, POPS. Pictures 01, 06 and 07 : Magid-Michel Saikaly, energy and infrastructure director at Converteam, receives a prize from Steve Myers, Director of Accelerators at CERN, for the development and fabrication of the new electrical power system for the PS, called POPS.

Administration of Bifidobacterium breve PS12929 and Lactobacillus salivarius PS12934, Two Strains Isolated from Human Milk, to Very Low and Extremely Low Birth Weight Preterm Infants: A Pilot Study

Directory of Open Access Journals (Sweden)

Laura Moles

2015-01-01

Full Text Available The preterm infant gut has been described as immature and colonized by an aberrant microbiota. Therefore, the use of probiotics is an attractive practice in hospitals to try to reduce morbidity and mortality in this population. The objective of this pilot study was to elucidate if administration of two probiotic strains isolated from human milk to preterm infants led to their presence in feces. In addition, the evolution of a wide spectrum of immunological compounds, including the inflammatory biomarker calprotectin, in both blood and fecal samples was also assessed. For this purpose, five preterm infants received two daily doses (~109 CFU of a 1 : 1 mixture of Bifidobacterium breve PS12929 and Lactobacillus salivarius PS12934. Bacterial growth was detected by culture-dependent techniques in all the fecal samples. The phylum Firmicutes dominated in nearly all fecal samples while L. salivarius PS12934 was detected in all the infants at numerous sample collection points and B. breve PS12929 appeared in five fecal samples. Finally, a noticeable decrease in the fecal calprotectin levels was observed along time.

Administration of Bifidobacterium breve PS12929 and Lactobacillus salivarius PS12934, two strains isolated from human milk, to very low and extremely low birth weight preterm infants: a pilot study.

Science.gov (United States)

Moles, Laura; Escribano, Esperanza; de Andrés, Javier; Montes, María Teresa; Rodríguez, Juan M; Jiménez, Esther; Sáenz de Pipaón, Miguel; Espinosa-Martos, Irene

2015-01-01

The preterm infant gut has been described as immature and colonized by an aberrant microbiota. Therefore, the use of probiotics is an attractive practice in hospitals to try to reduce morbidity and mortality in this population. The objective of this pilot study was to elucidate if administration of two probiotic strains isolated from human milk to preterm infants led to their presence in feces. In addition, the evolution of a wide spectrum of immunological compounds, including the inflammatory biomarker calprotectin, in both blood and fecal samples was also assessed. For this purpose, five preterm infants received two daily doses (~10(9) CFU) of a 1:1 mixture of Bifidobacterium breve PS12929 and Lactobacillus salivarius PS12934. Bacterial growth was detected by culture-dependent techniques in all the fecal samples. The phylum Firmicutes dominated in nearly all fecal samples while L. salivarius PS12934 was detected in all the infants at numerous sample collection points and B. breve PS12929 appeared in five fecal samples. Finally, a noticeable decrease in the fecal calprotectin levels was observed along time.

PS Booster Orbit Correction

CERN Document Server

Chanel, M; Rumolo, G; Tomás, R; CERN. Geneva. AB Department

2008-01-01

At the end of the 2007 run, orbit measurements were carried out in the 4 rings of the PS Booster (PSB) for different working points and beam energies. The aim of these measurements was to provide the necessary input data for a PSB realignment campaign during the 2007/2008 shutdown. Currently, only very few corrector magnets can be operated reliably in the PSB; therefore the orbit correction has to be achieved by displacing (horizontally and vertically) and/or tilting some of the defocusing quadrupoles (QDs). In this report we first describe the orbit measurements, followed by a detailed explanation of the orbit correction strategy. Results and conclusions are presented in the last section.

Determination and applications of enhancement factors for positron and ortho-positronium annihilations

International Nuclear Information System (INIS)

Mitroy, J.

2005-01-01

Electron-positron annihilation rates calculated directly from the electron and positron densities are known to underestimate the true annihilation rate. A correction factor, known as the enhancement factor, allows for the local increase of the electron density around the positron caused by the attractive electron-positron interaction. Enhancement factors are given for positrons annihilating with the 1s electron in H, He + , He, Li 2+ , and Li + . The enhancement factor for a free positron annihilating with He + and He is found to be close to that of ortho-positronium (i.e., Ps in its triplet state) annihilating with these atoms. The enhancement factor for Ps-He scattering is used in conjunction with the known annihilation rate for pickoff annihilation to derive a scattering length of 1.47a 0 for Ps-He scattering. Further, enhancement factors for e + -Ne and e + -Ar annihilation are used in conjunction with the pickoff annihilation rate to estimate scattering lengths of 1.46a 0 for Ps-Ne scattering and 1.75a 0 for Ps-Ar scattering

Microproteins (miPs) - the next big thing.

Science.gov (United States)

Feller, Stephan

2012-12-18

With iPS cells, sncRNAs, chromatin modification regulation and cancer stem cells already cooling off again, i.e. not being guaranteed publications in the 'ultimate' journals anymore, what will be very soon the new red-hot (or super-cool, i.e. anything but lukewarm) 'kid on the block'? We would vote for microproteins.

Characterization of in vivo MRI detectable thalamic amyloid plaques from APP/PS1 mice

Energy Technology Data Exchange (ETDEWEB)

Dhenain, M. [URA CEA CNRS 2210, I2BM, SHFJ, 4 Place du General Leclerc, 91401 Orsay Cedex (France); Dhenain, M.; El Tannir El Tayara, N.; Wu, T.D.; Volk, A.; Quintana, C. [U759 INSERM, Centre Universitaire, Laboratoire 112, 91405 Orsay Cedex (France); Dhenain, M.; El Tannir El Tayara, N.; Wu, T.D.; Volk, A.; Quintana, C. [Institut Curie, Centre Universitaire, Laboratoire 112, 91405 Orsay Cedex (France); Guegan, M.; Delatour, B. [Instituto de Microelectronica de Madrid-CSIC, 8, Isaac Newton, 28760 Tres Cantos, Madrid (Spain)

2009-07-01

Amyloid deposits are one of the hallmarks of Alzheimer's disease. Recent studies, in transgenic mice modeling Alzheimer's disease showed that, using in vivo, contrast agent-free, MRI, thalamic amyloid plaques are more easily detected than other plaques of the brain. Our study evaluated the characteristics of these thalamic plaques in a large population of APP/PS1, PS1 and C57BL/6 mice. Thalamic spots were detected in all mice but with different frequency and magnitude. Hence, the prevalence and size of the lesions were higher in APP/PS1 mice. However, even in APP/PS1 mice, thalamic spots did not occur in all the old animals. In APP/PS1 mice, spots detection was related to high iron and calcium load within amyloid plaques and thus reflects the ability of such plaque to capture large amounts of minerals. Interestingly, calcium and iron was also detected in extra-thalamic plaques but with a lower intensity. Hypointense lesions in the thalamus were not associated with the iron load in the tissue surrounding the plaques, nor with micro-hemorrhages, inflammation, or a neuro-degenerative context. (authors)

Cylindrical Hall Thrusters with Permanent Magnets

International Nuclear Information System (INIS)

Raitses, Yevgeny; Merino, Enrique; Fisch, Nathaniel J.

2010-01-01

The use of permanent magnets instead of electromagnet coils for low power Hall thrusters can offer a significant reduction of both the total electric power consumption and the thruster mass. Two permanent magnet versions of the miniaturized cylindrical Hall thruster (CHT) of different overall dimensions were operated in the power range of 50W-300 W. The discharge and plasma plume measurements revealed that the CHT thrusters with permanent magnets and electromagnet coils operate rather differently. In particular, the angular ion current density distribution from the permanent magnet thrusters has an unusual halo shape, with a majority of high energy ions flowing at large angles with respect to the thruster centerline. Differences in the magnetic field topology outside the thruster channel and in the vicinity of the channel exit are likely responsible for the differences in the plume characteristics measured for the CHTs with electromagnets and permanent magnets. It is shown that the presence of the reversing-direction or cusp-type magnetic field configuration inside the thruster channel without a strong axial magnetic field outside the thruster channel does not lead to the halo plasma plume from the CHT.

Macroscopic simulation of isotropic permanent magnets

International Nuclear Information System (INIS)

Bruckner, Florian; Abert, Claas; Vogler, Christoph; Heinrichs, Frank; Satz, Armin; Ausserlechner, Udo; Binder, Gernot; Koeck, Helmut; Suess, Dieter

2016-01-01

Accurate simulations of isotropic permanent magnets require to take the magnetization process into account and consider the anisotropic, nonlinear, and hysteretic material behaviour near the saturation configuration. An efficient method for the solution of the magnetostatic Maxwell equations including the description of isotropic permanent magnets is presented. The algorithm can easily be implemented on top of existing finite element methods and does not require a full characterization of the hysteresis of the magnetic material. Strayfield measurements of an isotropic permanent magnet and simulation results are in good agreement and highlight the importance of a proper description of the isotropic material. - Highlights: • Simulations of isotropic permanent magnets. • Accurate calculation of remanence magnetization and strayfield. • Comparison with strayfield measurements and anisotropic magnet simulations. • Efficient 3D FEM–BEM coupling for solution of Maxwell equations.

Low-voltage operating flexible ferroelectric organic field-effect transistor nonvolatile memory with a vertical phase separation P(VDF-TrFE-CTFE)/PS dielectric

Science.gov (United States)

Xu, Meili; Xiang, Lanyi; Xu, Ting; Wang, Wei; Xie, Wenfa; Zhou, Dayu

2017-10-01

Future flexible electronic systems require memory devices combining low-power operation and mechanical bendability. However, high programming/erasing voltages, which are universally needed to switch the storage states in previously reported ferroelectric organic field-effect transistor (Fe-OFET) nonvolatile memories (NVMs), severely prevent their practical applications. In this work, we develop a route to achieve a low-voltage operating flexible Fe-OFET NVM. Utilizing vertical phase separation, an ultrathin self-organized poly(styrene) (PS) buffering layer covers the surface of the ferroelectric polymer layer by one-step spin-coating from their blending solution. The ferroelectric polymer with a low coercive field contributes to low-voltage operation in the Fe-OFET NVM. The polymer PS contributes to the improvement of mobility, attributing to screening the charge scattering and decreasing the surface roughness. As a result, a high performance flexible Fe-OFET NVM is achieved at the low P/E voltages of ±10 V, with a mobility larger than 0.2 cm2 V-1 s-1, a reliable P/E endurance over 150 cycles, stable data storage retention capability over 104 s, and excellent mechanical bending durability with a slight performance degradation after 1000 repetitive tensile bending cycles at a curvature radius of 5.5 mm.

Reactor safety review of permanent changes

International Nuclear Information System (INIS)

Lam, K.F.

1997-01-01

Operational compliance engineers review all changes as part of a change control process. Each change, permanent or temporary, is required to undergo an intricate review process to ensure that the benefits associated with the change outweigh the risk. For permanent changes, it is necessary to ensure that the proposed design meets the nuclear safety requirements, conforms to the licensing requirements and complies with regulatory requirements. In addition, during installation of the permanent change and prior to in-service, a configuration management process is in place to align the change with operating and maintenance documents. (author)

Permanent multipole magnets with adjustable strength

International Nuclear Information System (INIS)

Halbach, K.

1983-01-01

Preceded by a short discussion of the motives for using permanent magnets in accelerators, a new type of permanent magnet for use in accelerators is presented. The basic design and most important properties of a quadrople will be described that uses both steel and permanent magnet material. The field gradient produced by this magnet can be adjusted without changing any other aspect of the field produced by this quadrupole. The generalization of this concept to produce other multipole fields, or combination of multipole fields, will also be presented

Nanocrystalline permanent magnets with enhanced properties

International Nuclear Information System (INIS)

Leonowicz, M.

2002-01-01

Parameters of permanent magnets result from the combination of intrinsic properties such as saturation magnetization, magnetic exchange, and magnetocrystalline energy, as well as microstructural parameters such as phase structure, grain size, and orientation. Reduction of grain size into nanocrystalline regime (∼ 50 nm) leads to the enhanced remanence which derives from ferromagnetic exchange coupling between highly refined grains. In this study the fundamental phenomena, quantities, and structure parameters, which define nanophase permanent magnets are presented and discussed. The theoretical considerations are confronted with experimental data for nanocrystalline Sm-Fe-N type permanent magnets. (author)

Permanent multipole magnets with adjustable strength

International Nuclear Information System (INIS)

Halbach, K.

1983-03-01

Preceded by a short discussion of the motives for using permanent magnets in accelerators, a new type of permanent magnet for use in accelerators is presented. The basic design and most important properties of a quadrupole will be described that uses both steel and permanent magnet material. The field gradient produced by this magnet can be adjusted without changing any other aspect of the field produced by this quadrupole. The generalization of this concept to produce other multipole fields, or combination of multipole fields, will also be presented

Ataxia telangiectasia derived iPS cells show preserved x-ray sensitivity and decreased chromosomal instability

OpenAIRE

Fukawatase, Yoshihiro; Toyoda, Masashi; Okamura, Kohji; Nakamura, Ken-ichi; Nakabayashi, Kazuhiko; Takada, Shuji; Yamazaki-Inoue, Mayu; Masuda, Akira; Nasu, Michiyo; Hata, Kenichiro; Hanaoka, Kazunori; Higuchi, Akon; Takubo, Kaiyo; Umezawa, Akihiro

2014-01-01

Ataxia telangiectasia is a neurodegenerative inherited disease with chromosomal instability and hypersensitivity to ionizing radiation. iPS cells lacking ATM (AT-iPS cells) exhibited hypersensitivity to X-ray irradiation, one of the characteristics of the disease. While parental ataxia telangiectasia cells exhibited significant chromosomal abnormalities, AT-iPS cells did not show any chromosomal instability in vitro for at least 80 passages (560 days). Whole exome analysis also showed a compa...

Virus-induced plasma membrane aquaporin PsPIP2;1 silencing inhibits plant water transport of Pisum sativum.

Science.gov (United States)

Song, Juanjuan; Ye, Guoliang; Qian, Zhengjiang; Ye, Qing

2016-12-01

Aquaporins (AQPs) are known to facilitate water transport across cell membranes, but the role of a single AQP in regulating plant water transport, particularly in plants other than Arabidopsis remains largely unexplored. In the present study, a virus-induced gene silencing (VIGS) technique was employed to suppress the expression of a specific plasma membrane aquaporin PsPIP2;1 of Pea plants (Pisum sativum), and subsequent effects of the gene suppression on root hydraulic conductivity (Lp r ), leaf hydraulic conductivity (K leaf ), root cell hydraulic conductivity (Lp rc ), and leaf cell hydraulic conductivity (Lp lc ) were investigated, using hydroponically grown Pea plants. Compared with control plants, VIGS-PsPIP2;1 plants displayed a significant suppression of PsPIP2;1 in both roots and leaves, while the expression of other four PIP isoforms (PsPIP1;1, PsPIP1;2, PsPIP2;2, and PsPIP2;3) that were simultaneously monitored were not altered. As a consequence, significant declines in water transport of VIGS-PsPIP2;1 plants were observed at both organ and cell levels, i.e., as compared to control plants, Lp r and K leaf were reduced by 29 %, and Lp rc and Lp lc were reduced by 20 and 29 %, respectively. Our results demonstrate that PsPIP2;1 alone contributes substantially to root and leaf water transport in Pea plants, and highlight VIGS a useful tool for investigating the role of a single AQP in regulating plant water transport.

Detection method of elastic scattering in the Coulomb interference region: scintillation target

International Nuclear Information System (INIS)

Azaiez, Hamza.

1981-01-01

Measurement of polarization in (p-p) elastic scattering in the Coulomb interference region is considered as a valid method for calibrating high energy polarized proton beams. Possibility of using a scintillation target to detect low energy recoil protons in this /t/ region has been studied by using a 4 GeV/c π - beam from CERN PS. The results obtained with a steack of thin plastic scintillators, each 1 mm thick, showed the feasibility of detecting recoil protons in a /t/ range as low a 5.10 -3 (GeV/c) 2 . This method thus confirmed experimentally can be used also to measure, using a polarized beam, polarization in Coulomb interference region [fr

PS proton source

CERN Multimedia

1959-01-01

The first proton source used at CERN's Proton Synchrotron (PS) which started operation in 1959. This is CERN's oldest accelerator still functioning today (2018). It is part of the accelerator chain that supplies proton beams to the Large Hadron Collider. The source is a Thonemann type. In order to extract and accelerate the protons at high energy, a high frequency electrical field is used (140Mhz). The field is transmitted by a coil around a discharge tube in order to maintain the gas hydrogen in an ionised state. An electrical field pulse, in the order of 15kV, is then applied via an impulse transformer between anode and cathode of the discharge tube. The electrons and protons of the plasma formed in the ionised gas in the tube, are then separated. Currents in the order of 200mA during 100 microseconds have benn obtained with this type of source.

Mõõtmise probleem 18. sajandi psühholoogias / Konstantin Ramul ; tõlk. Kenn Konstabel

Index Scriptorium Estoniae

Ramul, Konstantin, 1879-1975

2004-01-01

Mentaalsete mõõtmiste tähtsusest 18. sajandil teadusliku psühholoogia arengule 19. sajandil. 18. sajandi erinevate autorite arvamustest psühholoogiliste mõõtmiste võimalustest ja meetoditest. Varem ilmunud: American Psychologist, 1960, nr. 15, lk. 256-265

Introduction to permanent magnets

International Nuclear Information System (INIS)

Zijlstra, H.

1985-01-01

Some general considerations concerning the application of permanent magnets are developed. The relevant magnet properties are discussed, with particular reference to Nd-Fe-B alloy. The author comes to the following conclusions; the air gap field B should be high, for high electrical efficiency; the magnet should face the air gap, for efficient use of the magnet material; the magnet material should therefore have a high remanence; and the new Nd-Fe-B magnet fits in nicely, having (potentially) the highest remanence ever reported in permanent magnets, combined with sufficient coercivity to sustain it

Thermal-neutron multiple scattering: critical double scattering

International Nuclear Information System (INIS)

Holm, W.A.

1976-01-01

A quantum mechanical formulation for multiple scattering of thermal-neutrons from macroscopic targets is presented and applied to single and double scattering. Critical nuclear scattering from liquids and critical magnetic scattering from ferromagnets are treated in detail in the quasielastic approximation for target systems slightly above their critical points. Numerical estimates are made of the double scattering contribution to the critical magnetic cross section using relevant parameters from actual experiments performed on various ferromagnets. The effect is to alter the usual Lorentzian line shape dependence on neutron wave vector transfer. Comparison with corresponding deviations in line shape resulting from the use of Fisher's modified form of the Ornstein-Zernike spin correlations within the framework of single scattering theory leads to values for the critical exponent eta of the modified correlations which reproduce the effect of double scattering. In addition, it is shown that by restricting the range of applicability of the multiple scattering theory from the outset to critical scattering, Glauber's high energy approximation can be used to provide a much simpler and more powerful description of multiple scattering effects. When sufficiently close to the critical point, it provides a closed form expression for the differential cross section which includes all orders of scattering and has the same form as the single scattering cross section with a modified exponent for the wave vector transfer

Semi-empirical formula for large pore-size estimation from o-Ps annihilation lifetime

International Nuclear Information System (INIS)

Nguyen Duc Thanh; Tran Quoc Dung; Luu Anh Tuyen; Khuong Thanh Tuan

2007-01-01

The o-Ps annihilation rate in large pore was investigated by the semi-classical approach. The semi-empirical formula that simply correlates between the pore size and the o-Ps lifetime was proposed. The calculated results agree well with experiment in the range from some angstroms to several ten nanometers size of pore. (author)

Influence of size and shape of sub-micrometer light scattering centers in ZnO-assisted TiO2 photoanode for dye-sensitized solar cells

Science.gov (United States)

Pham, Trang T. T.; Mathews, Nripan; Lam, Yeng-Ming; Mhaisalkar, Subodh

2018-03-01

Sub-micrometer cavities have been incorporated in the TiO2 photoanode of dye-sensitized solar cell to enhance its optical property with light scattering effect. These are large pores of several hundred nanometers in size and scatter incident light due to the difference refraction index between the scattering center and the surrounding materials, according to Mie theory. The pores are created using polystyrene (PS) or zinc oxide (ZnO) templates reported previously which resulted in ellipsoidal and spherical shapes, respectively. The effect of size and shape of scattering center was modeled using a numerical analysis finite-difference time-domain (FDTD). The scattering cross-section was not affected significantly with different shapes if the total displacement volume of the scattering center is comparable. Experiments were carried out to evaluate the optical property with varying size of ZnO templates. Photovoltaic effect of dye-sensitized solar cells made from these ZnO-assisted films were investigated with incident-photon-to-current efficiency to understand the effect of scattering center size on the enhancement of absorption. With 380 nm macropores incorporated, the power conversion efficiency has increased by 11% mostly thanks to the improved current density, while 170 nm and 500 nm macropores samples did not have increment in sufficiently wide range of absorbing wavelengths.

1170-MW(t) HTGR-PS/C plant application-study report: alumina-plant application

International Nuclear Information System (INIS)

Rao, R.; McMain, A.T. Jr.; Stanley, J.D.

1981-05-01

This report considers the HTGR-PS/C application to producing alumina from bauxite. For the size alumina plant considered, the 1170-MW(t) HTGR-PS/C supplies 100% of the process steam and electrical power requirements and produces surplus electrical power and/or process steam, which can be used for other process users or electrical power production. Presently, the bauxite ore is reduced to alumina in plants geographically separated from the electrolysis plant. The electrolysis plants are located near economical electric power sources. However, with the integration of an 1170-MW(t) HTGR-PS/C unit in a commercial alumina plant, the excess electric power available [approx. 233 MW(e)] could be used for alumina electrolysis

The 1.4 GeV PS Booster in its tunnel.

CERN Multimedia

Patrice Loïez

2002-01-01

The PS Improvement Programme, launched as early as 1964, had a "Booster" as the key element in the quest for higher beam intensity and density. These were limited in the PS at injection of the 50 MeV proton beam from the linac by the incoherent (Laslett-) Q-shift. Boosting the linac beam to 800 MeV would raise the PS intensity limit by an order of magnitude, from 1E12 protons per pulse to 1E13. The main motivation was the supply of intense beams to the ISR. Soon, the Booster proved to be crucial for the neutral current experiment. A unique feature of the Booster are its 4 superposed rings. Its lattice is also unusual: between its 32 bending magnets, every second straight section contains a quadrupole triplet (F,D,F), while the alternate ones are drift spaces (mostly filled with essential components like septa, kickers, RF-cavities, etc.). In each picture we see one of the 16 periods. Following the direction of the beam from right to left: a bending magnet (green); an empty straight section; a bending magnet; ...

Assessment of Polarimetric SAR Interferometry for Improving Ship Classification based on Simulated Data

Directory of Open Access Journals (Sweden)

Jordi J. Mallorqui

2008-12-01

Full Text Available This paper uses a complete and realistic SAR simulation processing chain, GRECOSAR, to study the potentialities of Polarimetric SAR Interferometry (POLInSAR in the development of new classification methods for ships. Its high processing efficiency and scenario flexibility have allowed to develop exhaustive scattering studies. The results have revealed, first, vessels’ geometries can be described by specific combinations of Permanent Polarimetric Scatterers (PePS and, second, each type of vessel could be characterized by a particular spatial and polarimetric distribution of PePS. Such properties have been recently exploited to propose a new Vessel Classification Algorithm (VCA working with POLInSAR data, which, according to several simulation tests, may provide promising performance in real scenarios. Along the paper, explanation of the main steps summarizing the whole research activity carried out with ships and GRECOSAR are provided as well as examples of the main results and VCA validation tests. Special attention will be devoted to the new improvements achieved, which are related to simulations processing a new and highly realistic sea surface model. The paper will show that, for POLInSAR data with fine resolution, VCA can help to classify ships with notable robustness under diverse and adverse observation conditions.

Permanent education

International Nuclear Information System (INIS)

Gardien, S.; Kirsch, R.

1998-01-01

The permanent education of the IPN-Lyon inscribes itself completely in the priorities of the tri-annual plan of education of CNRS. These priorities contribute to evolution of research, evaluation of the professions, integration during the professional carriers of the personnel and form the frame for new management practice implementation

Transient or permanent fisheye views

DEFF Research Database (Denmark)

Jakobsen, Mikkel Rønne; Hornbæk, Kasper

2012-01-01

Transient use of information visualization may support specific tasks without permanently changing the user interface. Transient visualizations provide immediate and transient use of information visualization close to and in the context of the user’s focus of attention. Little is known, however......, about the benefits and limitations of transient visualizations. We describe an experiment that compares the usability of a fisheye view that participants could call up temporarily, a permanent fisheye view, and a linear view: all interfaces gave access to source code in the editor of a widespread...... programming environment. Fourteen participants performed varied tasks involving navigation and understanding of source code. Participants used the three interfaces for between four and six hours in all. Time and accuracy measures were inconclusive, but subjective data showed a preference for the permanent...

Permanent molars: Delayed development and eruption

Directory of Open Access Journals (Sweden)

Arathi R

2006-05-01

Full Text Available Delayed development and eruption of all the permanent molars is a rare phenomenon, which can cause disturbance in the developing occlusion. The eruption of permanent first and second molars is very important for the coordination of facial growth and for providing sufficient occlusal support for undisturbed mastication. In the case described, the first permanent molars were delayed in their development and were seen erupting at the age of nine and a half years. Severe disparity between the left and the right side of the dentition with respect to the rate of development of molars were also present.

7YSZ coating prepared by PS-PVD based on heterogeneous nucleation

Directory of Open Access Journals (Sweden)

Ziqian DENG

2018-04-01

Full Text Available Plasma spray-physical vapor deposition (PS-PVD as a novel coating process based on low-pressure plasma spray (LPPS has been significantly used for thermal barrier coatings (TBCs. A coating can be deposited from liquid splats, nano-sized clusters, and the vapor phase forming different structured coatings, which shows obvious advantages in contrast to conventional technologies like atmospheric plasma spray (APS and electron beam-physical vapor deposition (EB-PVD. In addition, it can be used to produce thin, dense, and porous ceramic coatings for special applications because of its special characteristics, such as high power, very low pressure, etc. These provide new opportunities to obtain different advanced microstructures, thus to meet the growing requirements of modern functional coatings. In this work, focusing on exploiting the potential of gas-phase deposition from PS-PVD, a series of 7YSZ coating experiments with various process conditions was performed in order to better understand the deposition process in PS-PVD, where coatings were deposited on different substrates including graphite and zirconia. Meanwhile, various substrate temperatures were investigated for the same substrate. As a result, a deposition mechanism of heterogeneous nucleation has been presented showing that surface energy is an important influencing factor for coating structures. Besides, undercooling of the interface between substrate and vapor phase plays an important role in coating structures. Keywords: 7YSZ, Deposition mechanism, Heterogeneous nucleation, PS-PVD, TBC

Nanoporous polymeric nanofibers based on selectively etched PS-b-PDMS block copolymers.

Science.gov (United States)

Demirel, Gokcen B; Buyukserin, Fatih; Morris, Michael A; Demirel, Gokhan

2012-01-01

One-dimensional nanoporous polymeric nanofibers have been fabricated within an anodic aluminum oxide (AAO) membrane by a facile approach based on selective etching of poly(dimethylsiloxane) (PDMS) domains in polystyrene-block-poly(dimethylsiloxane) (PS-b-PDMS) block copolymers that had been formed within the AAO template. It was observed that prior to etching, the well-ordered PS-b-PDMS nanofibers are solid and do not have any porosity. The postetched PS nanofibers, on the other hand, had a highly porous structure having about 20-50 nm pore size. The nanoporous polymeric fibers were also employed as a drug carrier for the native, continuous, and pulsatile drug release using Rhodamine B (RB) as a model drug. These studies showed that enhanced drug release and tunable drug dosage can be achieved by using ultrasound irradiation. © 2011 American Chemical Society

Chronic Stress Contributes to Cognitive Dysfunction and Hippocampal Metabolic Abnormalities in APP/PS1 Mice

Directory of Open Access Journals (Sweden)

Bing Han

2017-03-01

Full Text Available Background/Aims: Stress response is determined by the brain, and the brain is a sensitive target for stress. Our previous experiments have confirmed that once the stress response is beyond the tolerable limit of the brain, particularly that of the hippocampus, it will have deleterious effects on hippocampal structure and function; however, the metabolic mechanisms for this are not well understood. Methods: Here, we used morris water maze, elisa and gas chromatography-time of flight/mass spectrometry to observe the changes in cognition, neuropathology and metabolomics in the hippocampus of APP/PS1 mice and wild-type (C57 mice caused by chronic unpredictable mild stress (CUMS, we also further explored the correlation between cognition and metabolomics. Results: We found that 4 weeks of CUMS aggravated cognitive impairment and increased amyloid-β deposition in APP/PS1 mice, but did not affect C57 mice. Under non-stress conditions, compared with C57 mice, there were 8 different metabolites in APP/PS1 mice. However, following CUMS, 3 different metabolites were changed compared with untreated C57 mice. Compared to APP/PS1 mice, there were 7 different metabolites in APP/PS1+CUMS mice. Among these alterations, 3-hydroxybutyric acid, valine, serine, beta-alanine and o-phosphorylethanolamine, which are involved in sphingolipid metabolism, synthesis and degradation of ketone bodies, and amino acid metabolism. Conclusion: The results indicate that APP/PS1 mice are more vulnerable to stress than C57 mice, and the metabolic mechanisms of stress-related cognitive impairment in APP/PS1 mice are related to multiple pathways and networks, including sphingolipid metabolism, synthesis and degradation of ketone bodies, and amino acid metabolism.

Quantitative characterization of gold nanoparticles by field-flow fractionation coupled online with light scattering detection and inductively coupled plasma mass spectrometry.

Science.gov (United States)

Schmidt, Bjørn; Loeschner, Katrin; Hadrup, Niels; Mortensen, Alicja; Sloth, Jens J; Koch, Christian Bender; Larsen, Erik H

2011-04-01

An analytical platform coupling asymmetric flow field-flow fractionation (AF(4)) with multiangle light scattering (MALS), dynamic light scattering (DLS), and inductively coupled plasma mass spectrometry (ICPMS) was established and used for separation and quantitative determination of size and mass concentration of nanoparticles (NPs) in aqueous suspension. Mixtures of three polystyrene (PS) NPs between 20 and 100 nm in diameter and mixtures of three gold (Au) NPs between 10 and 60 nm in diameter were separated by AF(4). The geometric diameters of the separated PS NPs and the hydrodynamic diameters of the Au and PS NPs were determined online by MALS and DLS, respectively. The three separated Au NPs were quantified by ICPMS and recovered at 50-95% of the injected masses, which ranged between approximately 8-80 ng of each nanoparticle size. Au NPs adhering to the membrane in the separation channel was found to be a major cause for incomplete recoveries. The lower limit of detection (LOD) ranged between 0.02 ng Au and 0.4 ng Au, with increasing LOD by increasing nanoparticle diameter. The analytical platform was applied to characterization of Au NPs in livers of rats, which were dosed with 10 nm, 60 nm, or a mixture of 10 and 60 nm nanoparticles by intravenous injection. The homogenized livers were solubilized in tetramethylammonium hydroxide (TMAH), and the recovery of Au NPs from the livers amounted to 86-123% of their total Au content. In spite of successful stabilization with bovine serum albumin even in alkaline medium, separation of the Au NPs by AF(4) was not possible due to association with undissolved remains of the alkali-treated liver tissues as demonstrated by electron microscopy images.

Superconducting permanent magnets

International Nuclear Information System (INIS)

Wipf, S.L.; Laquer, H.L.

1989-01-01

The concept of superconducting permanent magnets with fields trapped in shells or cylinders of Type II superconductors is an old one. Unfortunately, the low values of 0.5 to 1T for the first flux jump field, which is independent of the actual current density, have frustrated its implementation with classical Type II superconductors. The fact that the flux jump fields for high temperature superconductors should be an order of magnitude larger at liquid nitrogen temperatures allows us to reconsider these options. Analysis of the hysteresis patterns, based on the critical state model, shows that, if the dimensions are chosen so that the sample is penetrated at a field B/sub p/, which is equal to or just less than the first flux jump field, B/sub fj/, a temporarily applied field of 2B/sub fj/ will trap 0.5 B/sub fj/. Thus for a 90 K superconductor with a B/sub fj/ of 6T, a permanent field of 3 T should be trapped, with an energy product of 1.8 MJ/m/sup 3/ (225 MG . Oe). This is five times as large as for the best permanent magnet materials. The authors discuss means to verify the analysis and the limitations imposed by the low critical current densities in presently available high temperature superconductors

Motor-Generator Set, PS Main Supply

CERN Multimedia

CERN PhotoLab

1983-01-01

This is the "new" motor-generator set. It replaced the previous, original, one which had served from the PS start-up in 1959. Ordered in 1965, installed in 1967, it was brought into operation at the beginning of 1968. Regularly serviced and fitted with modern regulation and controls, it still serves at the time of writing (2006) and promises to serve for several more years, as a very much alive museum-piece. See also 6803016 and 0201010.

PS overcomes two serious magnet failures

CERN Multimedia

Maximilien Brice

2003-01-01

Two magnets and a bus bar connection in the PS were found to be faulty during high-voltage tests at the end of the accelerator shutdown. A five-week repair schedule was quickly devised. A team of mechanics, technicians and engineers worked at full speed to replace the faulty magnets, succeeding in limiting the delay of the accelerators´ spring start-up to two weeks. Here we see one of the replacement magnets (no. 19) being prepared.

PS overcomes two serious magnet failures

CERN Multimedia

Maximilien Brice

2003-01-01

Two magnets and a bus bar connection in the PS were found to be faulty during high-voltage tests at the end of the accelerator shutdown. A five-week repair schedule was quickly devised. A team of mechanics, technicians and engineers worked at full speed to replace the faulty magnets, succeeding in limiting the delay of the accelerators' spring start-up to two weeks. Here we see one of the replacement magnets (no. 6) being prepared.

Measuring target for the PS Booster

CERN Multimedia

1971-01-01

The measuring target for the PS Booster (originally 800 MeV, now 1.4 GeV). It measures the size of the beam by destroying all particles with amplitudes greater than the size of the fork, the position and width of which are adjustable. The plunging time is only 20 ms and the acceleration at the tip of the fork reaches 90 g. The servo-controlled linear motor is shown detached from the mechanism. See also 7602008.

Efficient programming of human eye conjunctiva-derived induced pluripotent stem (ECiPS) cells into definitive endoderm-like cells.

Science.gov (United States)

Massumi, Mohammad; Hoveizi, Elham; Baktash, Parvaneh; Hooti, Abdollah; Ghazizadeh, Leili; Nadri, Samad; Pourasgari, Farzaneh; Hajarizadeh, Athena; Soleimani, Masoud; Nabiuni, Mohammad; Khorramizadeh, Mohammad R

2014-03-10

Due to pluripotency of induced pluripotent stem (iPS) cells, and the lack of immunological incompatibility and ethical issues, iPS cells have been considered as an invaluable cell source for future cell replacement therapy. This study was aimed first at establishment of novel iPS cells, ECiPS, which directly reprogrammed from human Eye Conjunctiva-derived Mesenchymal Stem Cells (EC-MSCs); second, comparing the inductive effects of Wnt3a/Activin A biomolecules to IDE1 small molecule in derivation of definitive endoderm (DE) from the ECiPS cells. To that end, first, the EC-MSCs were transduced by SOKM-expressing lentiviruses and characterized for endogenous expression of embryonic markers Then the established ECiPS cells were induced to DE formation by Wnt3a/Activin A or IDE1. Quantification of GSC, Sox17 and Foxa2 expression, as DE-specific markers, in both mRNA and protein levels revealed that induction of ECiPS cells by either Wnt3a/Activin A or IDE1 could enhance the expression level of the genes; however the levels of increase were higher in Wnt3a/Activin A induced ECiPS-EBs than IDE1 induced cells. Furthermore, the flow cytometry analyses showed no synergistic effect between Activin A and Wnt3a to derive DE-like cells from ECiPS cells. The comparative findings suggest that although both Wnt3a/Activin A signaling and IDE1 molecule could be used for differentiation of iPS into DE cells, the DE-inducing effect of Wnt3a/Activin A was statistically higher than IDE1. Copyright © 2014 Elsevier Inc. All rights reserved.

Beyond metric gravity: Progress on PS-200

International Nuclear Information System (INIS)

Goldman, T.; Brown, R.E.; Camp, J.B.; Darling, T.; Dyer, P.; Holzscheiter, M.H.; Hughes, R.J.; Jarmie, N.; King, N.S.P.; Lizon, D.C.; Nieto, M.M.; Schauer, M.M.M.; Schecker, J.A.; Cornford, S.; Hosea, K.; Kenefick, R.A.; Hoibraaten, S.; Midzor, M.M.; Parry, S.P.; Ristenen, R.A.; Witteborn, F.C.

1993-01-01

The reconciliation of quantum mechanics and gravity on varying distance scales requires changes to General Relativity that may be testable implications. We briefly review the status of tests with matter of the inverse square law and the principle of equivalence, then report on progress on the drift-tube measurement section of PS- 200, the experiment to measure the gravitational acceleration of antiprotons

Nanostructured silicate substituted calcium phosphate (NanoSiCaPs) nanoparticles — Efficient calcium phosphate based non-viral gene delivery systems

Energy Technology Data Exchange (ETDEWEB)

Shekhar, Sudhanshu [Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261 (United States); Center for Complex Engineered Multifunctional Materials, University of Pittsburgh, Pittsburgh, PA 15261 (United States); McGowan Institute of Regenerative Medicine, University of Pittsburgh, PA 15261 (United States); Roy, Abhijit; Hong, Daeho [Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261 (United States); Kumta, Prashant N., E-mail: pkumta@pitt.edu [Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261 (United States); Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA 15261 (United States); Department of Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, PA 15260 (United States); Center for Complex Engineered Multifunctional Materials, University of Pittsburgh, Pittsburgh, PA 15261 (United States); McGowan Institute of Regenerative Medicine, University of Pittsburgh, PA 15261 (United States)

2016-12-01

Nanostructured ceramic particles, particularly, nanoparticles of calcium phosphate (CaP) remain an attractive option among the various types of non-viral gene delivery vectors studied because of their safety, biocompatibility, biodegradability, and ease of handling as well as their adsorptive capacity for DNA. We have accordingly developed an enhanced version of nanostructured calcium phosphates (NanoCaPs), by substituting known amounts of silicate for phosphate in the hydroxyapatite (HA) lattice (NanoSiCaPs). Results indicate that in addition to the excellent transfection levels exhibited by un-substituted NanoCaPs alone in vitro, an additional 20–50% increase in transfection is observed for NanoCaPs containing 8.3–50 mol% silicate aptly called NanoSiCaPs, owing to its rapid dissolution properties enabling nanoparticles escaping the lysosomal degradation. However, high silicate substitution (> 50 mol%) resulted in a drastic decline in transfection as the synthesized NanoCaPs deviated far from the characteristic hydroxyapatite phase formed as evidenced by the materials characterization results. - Highlights: • Successful demonstration of nanostructured NanoSiCaPs formation • Demonstration of superior transfection of NanoSiCaPs contrasted to NanoCaPs • Silicate substitution leads to smaller aggregates of nanoparticle complexes. • Enhanced dissolution of NanoSiCaPs demonstrated • Faster NanoSiCaPs dissolution leads to escape of pDNA from lysosomal degradation.

Spectra and relaxation dynamics of the pseudohalide (PS) vibrational bands for Ru(bpy){sub 2}(PS){sub 2} complexes, PS = CN, NCS and N{sub 3}

Energy Technology Data Exchange (ETDEWEB)

Compton, Ryan; Gerardi, Helen K. [Chemistry Division, Naval Research Laboratory, Washington, DC 20375 (United States); Weidinger, Daniel [SRA International, 4300 Fair Lakes Court, Fairfax, VA 22033 (United States); Brown, Douglas J. [Chemistry Department, US Naval Academy, Annapolis, MD 21402 (United States); Dressick, Walter J. [Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375 (United States); Heilweil, Edwin J. [Radiation and Biomolecular Physics Division, Physical Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899 (United States); Owrutsky, Jeffrey C., E-mail: Jeff.Owrutsky@nrl.navy.mil [Chemistry Division, Naval Research Laboratory, Washington, DC 20375 (United States)

2013-08-30

Highlights: ► Static and transient infrared spectroscopy of pseudohalide bipyridine ruthenium complexes. ► Vibrational energy relaxes faster for the azide than the thiocyanate and cyanide analogs. ► Intramolecular vibrational relaxation is prevalent in cis-Ru(bpy){sub 2}(N{sub 3}){sub 2}. - Abstract: Static and transient infrared spectroscopy were used to investigate cis-Ru(bpy){sub 2}(N{sub 3}){sub 2} (bpy = 2,2′-bipyridine), cis-Ru(bpy){sub 2}(NCS){sub 2}, and cis-Ru(bpy){sub 2}(CN){sub 2} in solution. The NC stretching IR band for cis-Ru(bpy){sub 2}(NCS){sub 2} appears at higher frequency (∼2106 cm{sup −1} in DMSO) than for the free NCS{sup −} anion while the IR bands for the azide and cyanide complexes are closer to those of the respective free anions. The vibrational energy relaxation (VER) lifetime for the azide complex is found to be much shorter (∼5 ps) than for either the NCS or CN species (both ∼70 ps in DMSO) and the lifetimes resemble those for each corresponding free anion in solution. However, for cis-Ru(bpy){sub 2}(N{sub 3}){sub 2}, it is determined that the transition frequency depends more on the solvent than the VER lifetime implying that intramolecular vibrational relaxation is predominant over solvent energy-extracting interactions. These results are compared to the behavior of other related metal complexes in solution.

Visualization of Individual Images in Patterned Organic-Inorganic Multilayers Using GISAXS-CT.

Science.gov (United States)

Ogawa, Hiroki; Nishikawa, Yukihiro; Takenaka, Mikihito; Fujiwara, Akihiko; Nakanishi, Yohei; Tsujii, Yoshinobu; Takata, Masaki; Kanaya, Toshiji

2017-05-16

Using grazing-incidence small-angle scattering (GISAXS) with computed tomography (CT), we have individually reconstructed the spatial distribution of a thin gold (Au) layer buried under a thin poly(styrene-b-2-vinylpyridine) (PS-b-P2VP) layer. Owing to the difference between total reflection angles of Au and PS-b-P2VP, the scattering profiles for Au nanoparticles and self-assembled nanostructures of PS-b-P2VP could be independently obtained by changing the X-ray angle of incidence. Reconstruction of scattering profiles allows one to separately characterize spatial distributions in Au and PS-b-P2VP nanostructures.

Antibodies to phosphatidylserine/prothrombin (aPS/PT) enhanced the diagnostic performance in Chinese patients with antiphospholipid syndrome.

Science.gov (United States)

Zhang, Shulan; Wu, Ziyan; Zhang, Wen; Zhao, Jiuliang; Norman, Gary L; Zeng, Xiaofeng; Zhang, Fengchun; Li, Yongzhe

2018-03-21

Increasing evidence has highlighted the role of non-criteria antiphospholipid antibodies (aPLs) as important supplements to the current criteria aPLs for the diagnosis of antiphospholipid syndrome (APS). In this retrospective study, we evaluated the clinical relevance of antibodies to phosphatidylserine/prothrombin (aPS/PT) in Chinese patients with APS. A total of 441 subjects were tested, including 101 patients with primary APS (PAPS), 140 patients with secondary APS (SAPS), 161 disease controls (DCs) and 39 healthy controls (HCs). Serum IgG/IgM aPS/PT was determined by ELISA. The levels of IgG/IgM aPS/PT were significantly increased in patients with APS compared with DCs and HCs. IgG and IgM aPS/PT were present in 29.7% and 54.5% of PAPS, and 42.1% and 53.6% of SAPS, respectively. For diagnosis of APS, IgG aCL exhibited the highest positive likelihood ratio (LR+) of 21.60, followed by LA (13.84), IgG aβ2GP1 (9.19) and IgG aPS/PT (8.49). aPS/PT was detected in 13.3% of seronegative PAPS patients and 31.3% of seronegative SAPS patients. LA exhibited the highest OR of 3.64 in identifying patients with thrombosis, followed by IgG aCL (OR, 2.63), IgG aPS/PT (OR, 2.55) and IgG aβ2GP1 (OR, 2.33). LA and IgG aCL were correlated with both arterial and venous thrombosis, whereas IgG aPS/PT and IgG aβ2GP1 correlated with venous or arterial thrombosis, respectively. Our findings suggest that the inclusion of IgG/IgM aPS/PT may enhance the diagnostic performance for APS, especially in those in whom APS is highly suspected, but conventional aPLs are repeatedly negative. In addition, IgG aPS/PT may contribute to identify patients at risk of thrombosis.

Fast and eco-friendly fabrication of uniform Ag substrates for highly sensitive surface-enhanced Raman scattering

Science.gov (United States)

Xu, Yongda; Li, Xin; Jiang, Lan; Meng, Ge; Ran, Peng; Lu, Yongfeng

2017-05-01

This study proposed a fast, simple, eco-friendly method for obtaining highly sensitive and uniform surface-enhanced Raman scattering (SERS) of silver (Ag) nanotextured substrates decorated with silver nanoparticles in open air. By splitting conventional femtosecond pulses (subpulse delay Δt = 0 ps) into pulse trains (subpulse delay Δt = 3 ps), the mean diameter of Ag nanoparticles was reduced by almost half and the amount of Ag nanoparticles with a diameter ranging from 20 to 60 nm was increased by more than 11 times. The substrate fabricated by femtosecond pulse trains has four main merits as follows: (1) High sensitivity: the maximum SERS enhancement factor is 1.26 × 109; (2) High efficiency: the fabrication rate can be up to 1600 μm2/s, which is 20-40 times faster than femtosecond photochemical reduction; (3) Good reproducibility: the relative standard deviation of the Raman signal intensity is 10.7%, which is one-third of that for conventional femtosecond laser; (4) Eco-friendly fabrication: neither chemical reagents nor vacuum conditions are needed during the fabrication process.

Cholinergic degeneration is associated with increased plaque deposition and cognitive impairment in APPswe/PS1dE9 mice

DEFF Research Database (Denmark)

Laursen, Bettina; Mørk, Arne; Plath, Niels

2013-01-01

mice was not due to a more extensive cholinergic degeneration since the reduction in choline acetyltransferase activity was similar following SAP treatment in APP/PS1 mice and Wt. Interestingly, plaque load was significantly increased in SAP treated APP/PS1 mice relative to sham lesioned APP/PS1 mice....... Additionally, APP/PS1 mice treated with SAP showed a tendency towards an increased level of soluble and insoluble Aß1-40 and Aß1-42 measured in brain tissue homogenate. Our results suggest that the combination of cholinergic degeneration and Aß overexpression in the APP/PS1 mouse model results in cognitive...... decline and accelerated plaque burden. SAP treated APP/PS1 mice might thus constitute an improved model of Alzheimer's disease-like neuropathology and cognitive deficits compared to the conventional APP/PS1 model without selective removal of basal forebrain cholinergic neurons....

PS buildings : reinforced concrete structure for shielding "bridge" pillar

CERN Multimedia

CERN PhotoLab

1956-01-01

The PS ring traverses the region between the experimental halls South and North (buildings Nos 150 and 151) under massive bridge-shaped concrete beams. This pillar stands at the S-W end of the structure.

The Development of the Genital Psoriasis Sexual Frequency Questionnaire (GenPs-SFQ) to Assess the Impact of Genital Psoriasis on Sexual Health.

Science.gov (United States)

Gottlieb, Alice B; Kirby, Brian; Ryan, Caitriona; Naegeli, April N; Burge, Russel; Potts Bleakman, Alison; Anatchkova, Milena D; Cather, Jennifer

2018-03-01

Patient-reported outcome measures (PROs) exist for psoriasis but not genital psoriasis (GenPs). This cross-sectional, qualitative study in patients with moderate-to-severe GenPs was conducted to support development of a PRO for measuring the impact of GenPs on sexual activity and to establish content validity. The impacts of GenPs were identified in a literature review. Findings from the literature review were discussed with clinicians, and then patients with GenPs were interviewed. From the literature review, 52 articles, 44 abstracts, and 41 clinical trials met predefined search criteria. Of these, 11 concepts emerged as having theoretical support for use as measurable impacts of psoriasis symptoms on patients; these concepts included sexual functioning and general health-related quality of life (HRQoL). These concepts were confirmed and expanded upon by two clinicians who routinely care for patients with GenPs. Interviews were then conducted with GenPs patients (n = 20) to discuss the impact of GenPs on their HRQoL. Eighty percent of patients reported that GenPs impacted sexual frequency. The two-item GenPs Sexual Frequency Questionnaire (GenPs-SFQ) was developed to assess limitations on sexual activity frequency because of GenPs. Cognitive debriefing with an additional 50 patients with GenPs confirmed the utility and understandability of the GenPs-SFQ. The GenPs-SFQ may have utility in clinical trials involving GenPs patients and in routine clinical practice. Eli Lilly and Company. Plain language summary available for this article.

Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice.

Science.gov (United States)

Leroy, Karelle; Ando, Kunie; Laporte, Vincent; Dedecker, Robert; Suain, Valérie; Authelet, Michèle; Héraud, Céline; Pierrot, Nathalie; Yilmaz, Zehra; Octave, Jean-Noël; Brion, Jean-Pierre

2012-12-01

Lack of tau expression has been reported to protect against excitotoxicity and to prevent memory deficits in mice expressing mutant amyloid precursor protein (APP) identified in familial Alzheimer disease. In APP mice, mutant presenilin 1 (PS1) enhances generation of Aβ42 and inhibits cell survival pathways. It is unknown whether the deficient phenotype induced by concomitant expression of mutant PS1 is rescued by absence of tau. In this study, we have analyzed the effect of tau deletion in mice expressing mutant APP and PS1. Although APP/PS1/tau(+/+) mice had a reduced survival, developed spatial memory deficits at 6 months and motor impairments at 12 months, these deficits were rescued in APP/PS1/tau(-/-) mice. Neuronal loss and synaptic loss in APP/PS1/tau(+/+) mice were rescued in the APP/PS1/tau(-/-) mice. The amyloid plaque burden was decreased by roughly 50% in the cortex and the spinal cord of the APP/PS1/tau(-/-) mice. The levels of soluble and insoluble Aβ40 and Aβ42, and the Aβ42/Aβ40 ratio were reduced in APP/PS1/tau(-/-) mice. Levels of phosphorylated APP, of β-C-terminal fragments (CTFs), and of β-secretase 1 (BACE1) were also reduced, suggesting that β-secretase cleavage of APP was reduced in APP/PS1/tau(-/-) mice. Our results indicate that tau deletion had a protective effect against amyloid induced toxicity even in the presence of mutant PS1 and reduced the production of Aβ. Copyright © 2012 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

Simultaneous small-angle neutron scattering and Fourier transform infrared spectroscopic measurements on cocrystals of syndiotactic polystyrene with polyethylene glycol dimethyl ethers.

Science.gov (United States)

Kaneko, Fumitoshi; Seto, Naoki; Sato, Shuma; Radulescu, Aurel; Schiavone, Maria Maddalena; Allgaier, Jürgen; Ute, Koichi

2016-10-01

Syndiotactic polystyrene (sPS) is a crystalline polymer which has a unique property; it is able to form cocrystals with a wide range of chemical compounds, in which the guest molecules are confined in the vacancies of the host sPS crystalline region. Recently, it has been found that even polyethylene glycol oligomers with a molecular weight of more than several hundreds can be introduced into the sPS crystalline region. It is quite important to know how such a long-chain molecule is stored in the host sPS lattice. To tackle this issue, a new simultaneous measurement method combing small-angle neutron scattering and Fourier transform infrared spectroscopy (SANS/FTIR), which has been recently developed by the authors, was applied to an sPS cocrystal with polyethylene glycol dimethyl ether with a molecular weight of 500 (PEGDME500). The temperature-dependent changes of the SANS profile and FTIR spectrum were followed from room temperature up to 413 K for a one-dimensionally oriented SANS/PEGDME500 cocrystal sample. The intensity of the reflections due to the stacking of crystalline lamellae showed a significant temperature dependence. The two-dimensional pattern in the high Q region of SANS also changed depending on temperature. The combined information obtained by SANS and FTIR suggested that PEGDME500 molecules are distributed in both the crystalline and amorphous regions in the low-temperature region close to room temperature, but they are predominantly included in the amorphous region in the high-temperature region. It was also suggested by the two-dimensional SANS profile that PEGDME500 molecules in the crystalline region have an elongated structure along the thickness direction of the crystalline lamellae.

Thermal stability of gold-PS nanocomposites thin films

Indian Academy of Sciences (India)

Low-temperature transmission electron microscopy (TEM) studies were performed on polystyrene (PS, w = 234 K) – Au nanoparticle composite thin films that were annealed up to 350°C under reduced pressure conditions. The composite thin films were prepared by wet chemical approach and the samples were then ...

PS-b-PMMA/PLA blends for nanoporous templates with hierarchical and tunable pore size

Science.gov (United States)

Nguyen, Thi-Hoa; Vayer, Marylène; Sinturel, Christophe

2018-01-01

Blends of poly(styrene)-block-poly(methyl methacrylate) (PS-b-PMMA) and poly(lactide) (PLA) were deposited in the form of thin films on the surface of modified silicon wafers and exposed to tetrahydrofuran (THF) vapor annealing. It was shown that in specific experimental conditions, a core-shell morphology consisting in cylinders with a PMMA shell and a PLA core, within a continuous matrix of PS, was formed. In this case, PLA naturally segregated in the core of the PMMA cylinders, minimizing the PS/PLA interaction, which constitutes the most incompatible pair (the interaction strength between the various components was confirmed in thin films of the corresponding polymer blends). Compared to other block copolymer/homopolymer blends described in the literature, this system exhibits unexpected high increase of the characteristic lengths of the system (center-to-center distance and diameter). This was attributed to a partial solubilization of the PLA in the PMMA corona (the two polymers are highly compatible), inducing an enhanced level of PS and PLA stretching caused by the strong repulsion between these two polymers. The selective extraction of the PLA yielded to porous domains with small dimensions (6 ± 2.5 nm), reaching the performances that are currently attained in highly incompatible block polymers with low molecular weight. Further PMMA removal revealed a second porosity level, with higher pores diameter and center-to-center distance compared to the neat PS-b-PMMA system. This work highlights how PS-b-PMMA, that currently represents one of the industrial standards nanoporous template precursors, can be modified in an easy and costless approach using PLA homopolymer addition.

Preparação, caracterização e degradação de blendas PS/TPS usando glicerol e óleo de buriti como plastificantes Preparation, characterization and degradation of PS/TPS blends using glycerol and buriti oil as plastiscizers

Directory of Open Access Journals (Sweden)

Daniela Schlemmer

2010-01-01

Full Text Available Poliestireno (PS é um dos materiais descartáveis mais usados no nosso cotidiano, mas ele não se decompõe facilmente. A adição de amido de mandioca ao PS pode melhorar a sua degradabilidade, tendo em vista ser o amido um polímero biodegradável. O objetivo deste trabalho foi desenvolver blendas de PS e (amido termoplástico TPS usando dois diferentes plastificantes: glicerol e óleo de buriti, sendo esse óleo um plastificante natural e original para o amido. As blendas PS/TPS foram preparadas em diversas composições por casting e em seguida caracterizadas por termogravimetria (TG, calorimetria exploratória diferencial (DSC, análise termomecânica (TMA e ressonância magnética nuclear (RMN 13C. As blendas PS/TPS com óleo de buriti apresentaram uma contínua redução em suas Tg e Ta. Nas blendas com glicerol esses parâmetros permaneceram praticamente constantes. As blendas também foram submetidas a testes de degradação no solo e depois analisadas por TG e RMN. A análise das blendas PS/TPS com óleo de buriti mostrou que houve um aumento da perda de massa nas curvas TG. Nos espectros de RMN 13C, todos os picos referentes ao amido desapareceram, depois do teste de aterro, sugerindo que houve consumo do amido das blendas por microorganismos. De acordo com as análises realizadas, a adição do TPS produzido com óleo de buriti pode melhorar a degradabilidade do PS.Polystyrene (PS is one of the most used disposable materials in our daily life, but it does not decompose easily. The addition of cassava starch to PS can improve its degradability since starch is a biodegradable polymer. The aim of this work was to develop blends of PS and thermoplastic starch (TPS using two different plasticizers: buriti glycerol and buriti oil, a novel and natural plasticizer for starch. PS/TPS blends were prepared in various contents with the casting technique and analyzed by thermogravimetry (TG, differential scanning calorimetry (DSC

Lawful Permanent Residents Fiscal Year 2011 Country

Data.gov (United States)

Department of Homeland Security — Lawful permanet residents (LPRs) are foreign nationals who have been gratned the right to reside permanently in the United States. LPRs are also known as 'permanent...

Effect of reactive monomer on PS-b-P2VP film.

Science.gov (United States)

Kim, H J; Shin, D M

2014-08-01

Poly(styrene-b-2-vinyl pyridine) (PS-b-P2VP) lamellar film which is hydrophobic block-hydrophilic polyelectrolyte block polymer of 52 kg/mol-b-57 kg/mol and PS-b-P2VP film with reactive monomer (RM257) were prepared for photonic gel films. The lamellar stacks, which is alternating layer of hydrophilic and hydrophobic moiety of PS-b-P2VP, were obtained by exposing the spin coated film under chloroform vapor. The lamellar films were quaternized with 5 wt% of iodomethane diluted by n-hexane. We reported about the influence of reactive monomer on those photonic gel films. Added reactive monomer photonic gel film had higher absorbance than pure photonic gel films. As a result the photonic gel film with RM had more clear color. The lamellar films were swollen by DI water, ethanol (aq) and calcium carbonate solution. The band gaps of the lamellar films were drastically shifted to longer wavelength swollen by calcium carbonate solution. And the lamellar films were shifted to shorter wave length swollen by ethanol. So each lamellar film showed different color.

Redetermination of AgNb2PS10 revealing a silver deficiency

Directory of Open Access Journals (Sweden)

Hoseop Yun

2009-08-01

Full Text Available In comparison with a previous crystallographic study [Goh et al. (2002. J. Solid State Chem. 168, 119–125] of the title compound, silver diniobium tris(disulfide tetrathiophosphate(V, that reports a full occupation of the silver position and isotropic displacement parameters for the atoms, the current redetermination reveals a silver deficiency with a site-occupation factor of 0.88 (1 and reports all atoms with anisotropic displacement parameters. The structure of Ag0.88Nb2PS10 is composed of ∞1[Nb2PS10] chains, which are built up from pairs of distorted bicapped trigonal-prismatic [NbS8] polyhedra forming [Nb2S12] dimers and of tetrahedral [PS4] groups. These chains are connected via the statistically disordered Ag+ ions, forming double layers. Adjacent layers are stacked solely through van der Waals forces into a three-dimensional structure. Short and long Nb—Nb distances [2.880 (1 and 3.770 (2 Å, respectively] alternate along the chain and S22− and S2− anionic species are observed.

The quinternary thiophosphate Cs0.5Ag0.5Nb2PS10

Directory of Open Access Journals (Sweden)

Sojeong Park

2010-07-01

Full Text Available The quinternary thiophosphate Cs0.5Ag0.5Nb2PS10, cesium silver tris(disulfido[tetrathiophosphato(V]diniobate(IV, has been prepared from the elements using a CsCl flux. The crystal structure is made up of ∞1[Nb2PS10] chains expanding along [010]. These chains are built up from bicapped trigonal-prismatic [Nb2S12] units and tetrahedral [PS4] groups and are linked through a linear S—Ag—S bridge, forming a two-dimensional layer. These layers then stack on top of each other, completing the three-dimensional structure with an undulating van der Waals gap. The disordered Cs+ ions reside on sites with half-occupation in the voids of this arrangement. Short [2.8843 (5 Å] and long [3.7316 (4 Å] Nb—Nb distances alternate along the chains, and anionic S22− and S2− species are observed. The charge balance of the compound can be represented by the formula [Cs+]0.5[Ag+]0.5[Nb4+]2[PS43−][S22−]3.

POPS: the 60MW power converter for the PS accelerator: Control strategy and performances

CERN Document Server

Boattini, Fulvio; Skawinski, Gregory

2015-01-01

The main power supply of Proton-Synchrotron (PS) accelerator is one of the biggest at CERN. The old rotating machine system has been replaced with a new NPC based DC/DC power supply named POPS (Power system for PS main magnets) with capacitor banks as energy storage mean. POPS is in operation since February 2011. The operation of the PS accelerator requires a specific design of the control system with very high performance requirements in term of accuracy and precision. This paper describes the main lines of the control strategies analyzing the problems encountered and the solutions adopted. The performances of the converter are presented throughout the paper.

Laboratory spectrum of the PS radical and related astronomical search

International Nuclear Information System (INIS)

Ohishi, M.; Yamamoto, S.; Saito, S.; Kawaguchi, K.; Suzuki, H.

1988-01-01

The millimeter-wave rotational spectrum of the PS radical (X 2Pi r) was observed in the laboratory for the first time in the frequency region of 79-293 GHz by discharging the mixture of PSCl3 and He. Some 44 lines were measured, and the rotational constant, the centrifugal distortion constant, the centrifugal distortion term of the spin-orbit coupling constant, the Lambda-type doubling constants, and the hyperfine coupling constants were determined. Based on the measured and calculated frequencies, an astronomical search for the interstellar and circumstellar PS radical was made without success in Orion KL, Sgr B2, L134N,IRC + 10216, VY CMa, and OH 231.8 + 4.2. 29 references

Permanent magnet design for high-speed superconducting bearings

Science.gov (United States)

Hull, John R.; Uherka, Kenneth L.; Abdoud, Robert G.

1996-01-01

A high temperature superconducting bearing including a permanent magnet rotor levitated by a high temperature superconducting structure. The rotor preferably includes one or more concentric permanent magnet rings coupled to permanent magnet ring structures having substantially triangular and quadrangular cross-sections. Both alternating and single direction polarity magnet structures can be used in the bearing.

The PS overcomes two serious magnet failures

CERN Multimedia

2003-01-01

Two magnets and a bus bar connection in the PS were found to be faulty during high-voltage tests at the end of the accelerator shutdown. A five-week repair schedule was quickly devised. A team of mechanics, technicians and engineers worked at full speed to replace the faulty magnets, succeeding in limiting the delay of the accelerators' spring start-up to two weeks.

The order-to-disorder transition behavior of PS-b-P2VP thin film system

Science.gov (United States)

Ahn, Hyungju; Ryu, Du

2013-03-01

We investigated the transition behavior such as the order-to-disorder transition (ODT) for symmetric poly(styrene)-block-poly(2-vinly pridine) (PS-b-P2VP) using SAXS and GISAXS for block copolymer bulks and films. The bulk transition temperature of PS-b-P2VP was significantly influenced by the interfacial interactions in thin films, leading to the different transition temperature. From these results, we will discuss about the interfacial interaction effects on the phase behaviors in bulks and thin films system of PS-b-P2VP.

Muon energy estimate through multiple scattering with the MACRO detector

Energy Technology Data Exchange (ETDEWEB)

Ambrosio, M.; Antolini, R.; Auriemma, G.; Bakari, D.; Baldini, A.; Barbarino, G.C.; Barish, B.C.; Battistoni, G.; Becherini, Y.; Bellotti, R.; Bemporad, C.; Bernardini, P.; Bilokon, H.; Bloise, C.; Bower, C.; Brigida, M.; Bussino, S.; Cafagna, F.; Calicchio, M.; Campana, D.; Candela, A.; Carboni, M.; Caruso, R.; Cassese, F.; Cecchini, S.; Cei, F.; Chiarella, V.; Choudhary, B.C.; Coutu, S.; Cozzi, M.; De Cataldo, G.; De Deo, M.; Dekhissi, H.; De Marzo, C.; De Mitri, I.; Derkaoui, J.; De Vincenzi, M.; Di Credico, A.; Dincecco, M.; Erriquez, O.; Favuzzi, C.; Forti, C.; Fusco, P.; Giacomelli, G.; Giannini, G.; Giglietto, N.; Giorgini, M.; Grassi, M.; Gray, L.; Grillo, A.; Guarino, F.; Gustavino, C.; Habig, A.; Hanson, K.; Heinz, R.; Iarocci, E.; Katsavounidis, E.; Katsavounidis, I.; Kearns, E.; Kim, H.; Kyriazopoulou, S.; Lamanna, E.; Lane, C.; Levin, D.S.; Lindozzi, M.; Lipari, P.; Longley, N.P.; Longo, M.J.; Loparco, F.; Maaroufi, F.; Mancarella, G.; Mandrioli, G.; Margiotta, A.; Marini, A.; Martello, D.; Marzari-Chiesa, A.; Mazziotta, M.N.; Michael, D.G.; Monacelli, P.; Montaruli, T.; Monteno, M.; Mufson, S.; Musser, J.; Nicolo, D.; Nolty, R.; Orth, C.; Osteria, G.; Palamara, O.; Patera, V.; Patrizii, L.; Pazzi, R.; Peck, C.W.; Perrone, L.; Petrera, S.; Pistilli, P.; Popa, V.; Raino, A.; Reynoldson, J.; Ronga, F.; Rrhioua, A.; Satriano, C.; Scapparone, E. E-mail: eugenio.scapparone@bo.infn.it; Scholberg, K.; Sciubba, A.; Serra, P.; Sioli, M. E-mail: maximiliano.sioli@bo.infn.it; Sirri, G.; Sitta, M.; Spinelli, P.; Spinetti, M.; Spurio, M.; Steinberg, R.; Stone, J.L.; Sulak, L.R.; Surdo, A.; Tarle, G.; Tatananni, E.; Togo, V.; Vakili, M.; Walter, C.W.; Webb, R

2002-10-21

Muon energy measurement represents an important issue for any experiment addressing neutrino-induced up-going muon studies. Since the neutrino oscillation probability depends on the neutrino energy, a measurement of the muon energy adds an important piece of information concerning the neutrino system. We show in this paper how the MACRO limited streamer tube system can be operated in drift mode by using the TDCs included in the QTPs, an electronics designed for magnetic monopole search. An improvement of the space resolution is obtained, through an analysis of the multiple scattering of muon tracks as they pass through our detector. This information can be used further to obtain an estimate of the energy of muons crossing the detector. Here we present the results of two dedicated tests, performed at CERN PS-T9 and SPS-X7 beam lines, to provide a full check of the electronics and to exploit the feasibility of such a multiple scattering analysis. We show that by using a neural network approach, we are able to reconstruct the muon energy for E{sub {mu}}<40 GeV. The test beam data provide an absolute energy calibration, which allows us to apply this method to MACRO data.

Permanent magnet design for high-speed superconducting bearings

International Nuclear Information System (INIS)

Hull, J.R.; Uherka, K.L.; Abdoud, R.G.

1996-01-01

A high temperature superconducting bearing including a permanent magnet rotor levitated by a high temperature superconducting structure is disclosed. The rotor preferably includes one or more concentric permanent magnet rings coupled to permanent magnet ring structures having substantially triangular and quadrangular cross-sections. Both alternating and single direction polarity magnet structures can be used in the bearing. 9 figs

The CERN PS/SL Controls Java Application Programming Interface

International Nuclear Information System (INIS)

I. Deloose; J. Cuperus; P. Charrue; F. DiMaio; K. Kostro; M. Vanden Eynden; W. Watson

1999-01-01

The PS/SL Convergence Project was launched in March 1998. Its objective is to deliver a common control as infrastructure for the CERN accelerators by year 2001. In the framework of this convergence activity, a project was launched to develop a Java Application Programming Interface (API) between programs written in the Java language and the PS and SL accelerator equipment. This Java API was specified and developed in collaboration with TJNAF. It is based on the Java CDEV [1] package that has been extended in order to end up with a CERN/TJNAF common product. It implements a detailed model composed of devices organized in named classes that provide a property-based interface. It supports data subscription and introspection facilities. The device model is presented and the capabilities of the API are described with syntax examples. The software architecture is also described

Four-frame gated optical imager with 120-ps resolution

International Nuclear Information System (INIS)

Young, P.E.; Hares, J.D.; Kilkenny, J.D.; Phillion, D.W.; Campbell, E.M.

1988-04-01

In this paper we describe the operation and applications of a framing camera capable of four separate two-dimensional images with each frame having a 120-ps gate width. Fast gating of a single frame is accomplished by using a wafer image intensifier tube in which the cathode is capacitively coupled to an external electrode placed outside of the photocathode of the tube. This electrode is then pulsed relative to the microchannel plate by a narrow (120 ps), high-voltage pulse. Multiple frames are obtained by using multiple gated tubes which share a single bias supply and pulser with relative gate times selected by the cable lengths between the tubes and the pulser. A beamsplitter system has been constructed which produces a separate image for each tube from a single scene. Applications of the framing camera to inertial confinement fusion experiments are discussed

The Automatic Test Features of the IDiPS Reactor Protection System

International Nuclear Information System (INIS)

Hur, Seop; Kim, Dong-Hoon; Hwang, In-Koo; Lee, Cheol-Kwon; Lee, Dong-Young

2007-01-01

The reactor protection system (RPS) is designed to minimize a propagation of abnormal or accident conditions of nuclear power plants. A digital RPS (Integrated Digital Protection System (IDiPS) RPS) is being developed in the Korea Nuclear Instrumentation and Control System (KNICS) R and D project. To make good use of the advantages of the digital technology, it is necessary to improve the reliability and availability of a system through automatic test features including an on-line testing, a self-diagnostics, an auto calibration, etc. This paper summarizes the system test strategy and the automatic test features of the IDiPS RPS

Thermodynamics parameters of nano-Ni/PS composites prepared by in situ polymerization method

International Nuclear Information System (INIS)

Liao Qilong; Xiong Jie; Ning Haixia

2011-01-01

Spherical nickel nanoparticles with about 75∼200 nm in size were obtained by a liquid reduction method. The nickel nanoparticles/PS composites were synthesized via in situ polymerization method. XRD, FTIR, SEM and TG-DSC were respectively used to measure the properties of nickel nanoparticles, the microstructure of as-prepared composites samples, the distribution of nickel nanoparticles in PS and the thermodynamic parameters of as-prepared composites. The results show that the nickel nanoparticles will enhance the glass transition temperature of nano-Ni/PS composites. The enthalpy of composites is heightened by increasing of doping dose, and it reaches the top when the doping dose is from 1% to 2%. The specific heat of the composites will reduce with the doping dose of nickel nanoparticles increasing. (authors)

Safety effects of permanent running lights for bicycles

DEFF Research Database (Denmark)

Madsen, Jens Chr. Overgaard; Andersen, T.; Lahrmann, Harry

2013-01-01

, including all recorded bicycle accidents with personal injury to the participating cyclist, is 19% lower for cyclists with permanent running lights mounted; indicating that the permanent bicycle running light significantly improves traffic safety for cyclists. The study shows that use of permanent bicycle......Making the use of daytime running lights mandatory for motor vehicles is generally documented to have had a positive impact upon traffic safety. Improving traffic safety for bicyclists is a focal point in the road traffic safety work in Denmark. In 2004 and 2005 a controlled experiment including...... 3845 cyclists was carried out in Odense, Denmark in order to examine, if permanent running lights mounted to bicycles would improve traffic safety for cyclists. The permanent running lights were mounted to 1845 bicycles and the accident rate was recorded through 12 months for this treatment group...

A high resolution animal PET scanner using compact PS-PMT detectors

International Nuclear Information System (INIS)

Watanabe, M.; Okada, H.; Shimizu, K.; Omura, T.

1996-01-01

A new high resolution PET scanner dedicated to animal studies has been designed, built and tested. The system utilizes 240 block detectors, each of which consists of a new compact position-sensitive photomultiplier tube (PS-PMT) and an 8 x 4 BGO array. A total number of 7,680 crystals (480 per ring) are positioned to form a 508 mm diameter of 16 detector rings with 7.2 mm pitch and 114 mm axial field of view (FOV). The system is designed to perform activation studies using a monkey in a sitting position. The data can be acquired in either 2D or 3D mode, where the slice collimators are retracted in 3D mode. The transaxial resolution is 2.6 mm FWHM at the center of the FOV, and the average axial resolution on the axis of the ring is 3.3 mm FWHM in the direct slice and 3.2 mm FWHM in the cross slice. The scatter fraction, sensitivity and count rate performance were evaluated for a 10 cm diameter cylindrical phantom. The total system sensitivity is 2.3 kcps/kBq/ml in 2D mode and 22.8 kcps/kBq/ml in 3D mode. The noise equivalent count rate with 3D mode is equivalent to that with 2D mode at five times higher radioactivity level. The applicable imaging capabilities of the scanner was demonstrated by animal studies with a monkey

The PS1 hairpin of Mcm3 is essential for viability and for DNA unwinding in vitro.

Directory of Open Access Journals (Sweden)

Simon K W Lam

Full Text Available The pre-sensor 1 (PS1 hairpin is found in ring-shaped helicases of the AAA+ family (ATPases associated with a variety of cellular activities of proteins and is implicated in DNA translocation during DNA unwinding of archaeal mini-chromosome maintenance (MCM and superfamily 3 viral replicative helicases. To determine whether the PS1 hairpin is required for the function of the eukaryotic replicative helicase, Mcm2-7 (also comprised of AAA+ proteins, we mutated the conserved lysine residue in the putative PS1 hairpin motif in each of the Saccharomyces cerevisiae Mcm2-7 subunits to alanine. Interestingly, only the PS1 hairpin of Mcm3 was essential for viability. While mutation of the PS1 hairpin in the remaining MCM subunits resulted in minimal phenotypes, with the exception of Mcm7 which showed slow growth under all conditions examined, the viable alleles were synthetic lethal with each other. Reconstituted Mcm2-7 containing Mcm3 with the PS1 mutation (Mcm3(K499A had severely decreased helicase activity. The lack of helicase activity provides a probable explanation for the inviability of the mcm3(K499A strain. The ATPase activity of Mcm2-7(3K499A was similar to the wild type complex, but its interaction with single-stranded DNA in an electrophoretic mobility shift assay and its associations in cells were subtly altered. Together, these findings indicate that the PS1 hairpins in the Mcm2-7 subunits have important and distinct functions, most evident by the essential nature of the Mcm3 PS1 hairpin in DNA unwinding.

Spatio-temporal responses of Arabidopsis leaves in photosynthetic performance and metabolite contents to Burkholderia phytofirmans PsJN

Directory of Open Access Journals (Sweden)

Fan eSu

2016-03-01

Full Text Available A valuable strategy to improve crop yield consists in the use of plant growth-promoting rhizobacteria (PGPRs. However, the influence of PGPR colonization on plant physiology is largely unknown. PGPR Burkholderia phytofirmans strain PsJN (Bp PsJN colonized only Arabidopsis thaliana roots after seed or soil inoculation. Foliar bacteria were detected only after leaf infiltration. Since different bacterial times of presence and/or locations in host plant could lead to different plant physiological responses, photosynthesis and metabolite profiles in A. thaliana leaves were thus investigated following leaf, root or seed inoculation with Bp PsJN. Only Bp PsJN leaf colonization transiently decreased cyclic electron transport and effective quantum yield of photosystem I (PSI, and prevented a decrease in net photosynthesis and stomatal opening compared to the corresponding control. Metabolomic analysis revealed that soluble sugars, amino acids or their derivatives accumulated differently in all Bp PsJN-inoculated plants. Octanoic acid accumulated only in case of inoculated plants. Modifications in vitamin, organic acid such as tricarboxylic acid intermediates, and hormone amounts were dependent on bacterial time of presence and location. Additionally, a larger array of amino acids and hormones (auxin, cytokinin, abscisic acid were modified by seed inoculation with Bp PsJN. Our work thereby provides evidence that relative short-term inoculation with Bp PsJN altered physiological status of A.thaliana leaves, whereas long-term bacterization triggered modifications on a larger set of metabolites. Our data highlighted the changes displayed during this plant-microbe interaction to trigger physiological and metabolic responses that could explain the increase in plant growth or stress tolerance conferred by the presence of Bp PsJN.

Temperature dependence of o-Ps annihilation lifetime in non-uniform cylindrical pores in comparison with ETE model

Energy Technology Data Exchange (ETDEWEB)

Khaghani, Morteza, E-mail: m.khaghani@pgs.usb.ac.ir; Mehmandoost-Khajeh-Dad, Ali Akbar, E-mail: mehmandoost@phys.usb.ac.ir

2017-04-01

Highlights: • Using the well known multi-physics program COMSOL calculating o-Ps annihilation lifetime in complex geometries. • Investigation of shape non-uniformity of cylindrical pores on o-Ps annihilation lifetime. • Verifying temperature dependency of o-Ps lifetime in non-uniform cylindrical pores. • Suggesting PALS at low temperature as a method to verify pore uniformity in porous material. - Abstract: Ortho-positronium (o-Ps) annihilation lifetime was calculated in non-uniform cylinder-shaped pores by solving Schrodinger equation using a well-known multi-physics program called COMSOL. The o-Ps annihilation lifetime variation in terms of temperature was calculated on the basis of ETE model via a numerical method. The COMSOL simulations indicate that as long as the pore is uniform cylinder-shaped, the results agree with those of two-dimensional ETE model, whereas deformations in the cylinder shape (indentation or protrusion) change the temperature behavior of ETE model and, thereby, higher values are predicted for o-Ps lifetime in the pore at lower temperatures. The geometry of the non-uniform cylinder-shaped pores, which is accompanied by empirical evidence, can be used for the analysis of empirical results obtained from positron lifetime spectroscopy in different temperatures.

Rahuoperatsioonide Keskuses alustab sotsiaalse ja psühholoogilise toetuse sektsioon / Merle Tihaste, Marge Sillaste

Index Scriptorium Estoniae

Parmak, Merle, 1968-

2008-01-01

Missioonidel osalevatele või pikaajalises lähetuses viibivatele kaitseväelastele ja nende peredele suunatud sotsiaalse ja psühholoogilise toetuse tagamiseks loodud sektsioonist Rahuoperatsioonide Keskuse koosseisus. Sektsiooni töömudelist, ülesannetest ja koostöövõrgustikust. Skeem: Sotsiaalse ja psühholoogilise toetuse sektsiooni töömudel ja partnerid

1170-MW(t) HTGR-PS/C plant application study report: heavy oil recovery application

International Nuclear Information System (INIS)

Rao, R.; McMain, A.T. Jr.

1981-05-01

This report describes the application of a high-temperature gas-cooled reactor (HTGR) which operates in a process steam/cogeneration (PS/C) mode in supplying steam for enhanced recovery of heavy oil and in exporting electricity. The technical and economic merits of an 1170-MW(t) HTGR-PS/C are compared with those of coal-fired plants and (product) oil-fired boilers for this application. The utility requirements for enhanced oil recovery were calculated by establishing a typical pattern of injection wells and production wells for an oil field similar to that of Kern County, California. The safety and licensing issues of the nuclear plant were reviewed, and a comparative assessment of the alternative energy sources was performed. Technically and economically, the HTGR-PS/C plant has attractive merits. The major offsetting factors would be a large-scale development of a heavy oil field by a potential user for the deployment of a 1170-MW(t) HTGR-PS/C; plant and the likelihood of available prime heavy oil fields for the mid-1990 operation

Controlled supramolecular assembly of micelle-like gold nanoparticles in PS-b-P2VP diblock copolymers via hydrogen bonding.

Science.gov (United States)

Jang, Se Gyu; Kramer, Edward J; Hawker, Craig J

2011-10-26

We report a facile strategy to synthesize amphiphilic gold (Au) nanoparticles functionalized with a multilayer, micelle-like structure consisting of a Au core, an inner hydroxylated polyisoprene (PIOH) layer, and an outer polystyrene shell (PS). Careful control of enthalpic interactions via a systematic variation of structural parameters, such as number of hydroxyl groups per ligand (N(OH)) and styrene repeating units (N(PS)) as well as areal chain density of ligands on the Au-core surface (Σ), enables precise control of the spatial distribution of these nanoparticles. This control was demonstrated in a lamellae-forming poly(styrene-b-2-vinylpyridine) (PS-b-P2VP) diblock copolymer matrix, where the favorable hydrogen-bonding interaction between hydroxyl groups in the PIOH inner shell and P2VP chains in the PS-b-P2VP diblock copolymer matrix, driving the nanoparticles to be segregated in P2VP domains, could be counter balanced by the enthalphic penalty of mixing of the PS outer brush with the P2VP domains. By varying N(OH), N(PS), and Σ, the nanoparticles could be positioned in the PS or P2VP domains or at the PS/P2VP interface. In addition, the effect of additives interfering with the hydrogen-bond formation between hydroxyl groups on Au nanoparticles and P2VP chains in a diblock copolymer matrix was investigated, and an interesting pea-pod-like segregation of Au nanoparticles in PS domains was observed.

Dental caries imaging using hyperspectral stimulated Raman scattering microscopy

Science.gov (United States)

Wang, Zi; Zheng, Wei; Jian, Lin; Huang, Zhiwei

2016-03-01

We report the development of a polarization-resolved hyperspectral stimulated Raman scattering (SRS) imaging technique based on a picosecond (ps) laser-pumped optical parametric oscillator system for label-free imaging of dental caries. In our imaging system, hyperspectral SRS images (512×512 pixels) in both fingerprint region (800-1800 cm-1) and high-wavenumber region (2800-3600 cm-1) are acquired in minutes by scanning the wavelength of OPO output, which is a thousand times faster than conventional confocal micro Raman imaging. SRS spectra variations from normal enamel to caries obtained from the hyperspectral SRS images show the loss of phosphate and carbonate in the carious region. While polarization-resolved SRS images at 959 cm-1 demonstrate that the caries has higher depolarization ratio. Our results demonstrate that the polarization resolved-hyperspectral SRS imaging technique developed allows for rapid identification of the biochemical and structural changes of dental caries.

RMS Pictorial Scale (RMS-PS: An innovative scale for the assessment of child′s dental anxiety

Directory of Open Access Journals (Sweden)

R M Shetty

2015-01-01

Full Text Available Background: Dental anxiety assessment for young children is as important as performing their treatment. Appropriate knowledge of patient′s anxiety boosts confidence and will help us to review potential management options specific to every child. Aim: This study aimed to validate (RMS Pictorial Scale (RMS-PS and to compare it with Venham Picture Test (VPT and Facial image scale (FIS in measuring dental anxiety for young children during their first dental visit. Materials and Methods: A total of 102 healthy children aged between 4 and 14 years during their first dental visit were randomly selected for the study. Childs anxiety level was measured using three different scales namely (i RMS-PS (ii VPT, and (iii FIS. Statistical Analysis: Student t test was used to compare the scores obtained from all the three scales. Pearson correlation test was used to obtain correlation among the scales used in the study. Results: A strong correlation (0·76 was found between the VPT and RMS-PS, and a moderate correlation (0.5 was found between RMS-PS and FIS, indicating good validity for the RMS-PS. Conclusions: The findings of this study suggest that the RMS-PS can be a newer and easiest means for the assessment of dental anxiety for young children in a clinical context.

Workplace bullying a risk for permanent employees.

Science.gov (United States)

Keuskamp, Dominic; Ziersch, Anna M; Baum, Fran E; Lamontagne, Anthony D

2012-04-01

We tested the hypothesis that the risk of experiencing workplace bullying was greater for those employed on casual contracts compared to permanent or ongoing employees. A cross-sectional population-based telephone survey was conducted in South Australia in 2009. Employment arrangements were classified by self-report into four categories: permanent, casual, fixed-term and self-employed. Self-report of workplace bullying was modelled using multiple logistic regression in relation to employment arrangement, controlling for sex, age, working hours, years in job, occupational skill level, marital status and a proxy for socioeconomic status. Workplace bullying was reported by 174 respondents (15.2%). Risk of workplace bullying was higher for being in a professional occupation, having a university education and being separated, divorced or widowed, but did not vary significantly by sex, age or job tenure. In adjusted multivariate logistic regression models, casual workers were significantly less likely than workers on permanent or fixed-term contracts to report bullying. Those separated, divorced or widowed had higher odds of reporting bullying than married, de facto or never-married workers. Contrary to expectation, workplace bullying was more often reported by permanent than casual employees. It may represent an exposure pathway not previously linked with the more idealised permanent employment arrangement. A finer understanding of psycho-social hazards across all employment arrangements is needed, with equal attention to the hazards associated with permanent as well as casual employment. © 2012 The Authors. ANZJPH © 2012 Public Health Association of Australia.

Syntheses, crystal structure, and electronic properties of the five ABaMQ{sub 4} compounds RbBaPS{sub 4}, CsBaPS{sub 4}, CsBaVS{sub 4}, RbBaVSe{sub 4}, and CsBaVSe{sub 4}

Energy Technology Data Exchange (ETDEWEB)

Mesbah, Adel [Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (United States); ICSM, UMR 5257 CEA / CNRS / UM / ENSCM, Site de Marcoule-Bâtiment 426, BP 17171, 30207 Bagnols-sur-Cèze Cedex (France); Prakash, Jai [Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (United States); Rocca, Dario; Lebègue, Sébastien [Laboratoire de Cristallographie, Résonance Magnétique, et Modélisations CRM2 (UMR UHP-CNRS 7036), Faculté des Sciences et Techniques, Université de Lorraine, BP 70239, Boulevard des Aiguillettes, 54506 Vandoeuvre-lès-Nancy Cedex (France); Beard, Jessica C.; Lewis, Benjamin A. [Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (United States); Ibers, James A., E-mail: ibers@chem.northwestern.edu [Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (United States)

2016-01-15

Five new compounds belonging to the ABaMQ{sub 4} family were synthesized by solid-state chemistry at 1123 K. The compounds RbBaPS{sub 4}, CsBaPS{sub 4}, CsBaVS{sub 4}, RbBaVSe{sub 4}, and CsBaVSe{sub 4} are isostructural and have the TlEuPS{sub 4} structure type. They crystallize in space group D{sup 16}{sub 2h} – Pnma of the orthorhombic system. Their structure consists isolated MQ{sub 4} tetrahedra separated by A and Ba atoms to form a salt-like structure. Density Functional Theory (DFT) calculations of the electronic structures with the use of the HSE functional suggest that the compounds are semiconductors with calculated band gaps of 3.3 eV (RbBaPS{sub 4}), 3.4 eV (CsBaPS{sub 4}), 2.3 eV (CsBaVS{sub 4}), and 1.6 eV (RbBaVSe{sub 4}). - Graphical abstract: General view of the ABaMQ{sub 4} structure down the a axis. - Highlights: • Five new ABaMQ{sub 4} compounds were synthesized by solid-state chemistry at 1123 K. • RbBaPS{sub 4}, CsBaPS{sub 4}, CsBaVS{sub 4}, RbBaVSe{sub 4}, and CsBaVSe{sub 4} have the TlEuPS{sub 4} structure type. • The compounds are semiconductors with calculated band gaps ranging from 1.6 to 3.4 eV.

Nonuniform radiation damage in permanent magnet quadrupoles.

Science.gov (United States)

Danly, C R; Merrill, F E; Barlow, D; Mariam, F G

2014-08-01

We present data that indicate nonuniform magnetization loss due to radiation damage in neodymium-iron-boron Halbach-style permanent magnet quadrupoles. The proton radiography (pRad) facility at Los Alamos uses permanent-magnet quadrupoles for magnifying lenses, and a system recently commissioned at GSI-Darmsdadt uses permanent magnets for its primary lenses. Large fluences of spallation neutrons can be produced in close proximity to these magnets when the proton beam is, intentionally or unintentionally, directed into the tungsten beam collimators; imaging experiments at LANL's pRad have shown image degradation with these magnetic lenses at proton beam doses lower than those expected to cause damage through radiation-induced reduction of the quadrupole strength alone. We have observed preferential degradation in portions of the permanent magnet quadrupole where the field intensity is highest, resulting in increased high-order multipole components.

Nonuniform radiation damage in permanent magnet quadrupoles

International Nuclear Information System (INIS)

Danly, C. R.; Merrill, F. E.; Barlow, D.; Mariam, F. G.

2014-01-01

We present data that indicate nonuniform magnetization loss due to radiation damage in neodymium-iron-boron Halbach-style permanent magnet quadrupoles. The proton radiography (pRad) facility at Los Alamos uses permanent-magnet quadrupoles for magnifying lenses, and a system recently commissioned at GSI-Darmsdadt uses permanent magnets for its primary lenses. Large fluences of spallation neutrons can be produced in close proximity to these magnets when the proton beam is, intentionally or unintentionally, directed into the tungsten beam collimators; imaging experiments at LANL’s pRad have shown image degradation with these magnetic lenses at proton beam doses lower than those expected to cause damage through radiation-induced reduction of the quadrupole strength alone. We have observed preferential degradation in portions of the permanent magnet quadrupole where the field intensity is highest, resulting in increased high-order multipole components

Nonuniform radiation damage in permanent magnet quadrupoles

Energy Technology Data Exchange (ETDEWEB)

Danly, C. R.; Merrill, F. E.; Barlow, D.; Mariam, F. G. [Los Alamos National Laboratory, Los Alamos, New Mexico 87544 (United States)

2014-08-15

We present data that indicate nonuniform magnetization loss due to radiation damage in neodymium-iron-boron Halbach-style permanent magnet quadrupoles. The proton radiography (pRad) facility at Los Alamos uses permanent-magnet quadrupoles for magnifying lenses, and a system recently commissioned at GSI-Darmsdadt uses permanent magnets for its primary lenses. Large fluences of spallation neutrons can be produced in close proximity to these magnets when the proton beam is, intentionally or unintentionally, directed into the tungsten beam collimators; imaging experiments at LANL’s pRad have shown image degradation with these magnetic lenses at proton beam doses lower than those expected to cause damage through radiation-induced reduction of the quadrupole strength alone. We have observed preferential degradation in portions of the permanent magnet quadrupole where the field intensity is highest, resulting in increased high-order multipole components.

Multi objective large power system planning under sever loading condition using learning DE-APSO-PS strategy

International Nuclear Information System (INIS)

Mahdad, Belkacem; Srairi, K.

2014-01-01

Highlights: • An efficient planning strategy using DE and APSO in coordination with PS algorithm is proposed. • An interactive process is proposed to balance the exploitation and exploration capability of (DE-APSO) and PS. • Fuel cost, power loss, and voltage deviation considering loading condition are optimized. • The proposed strategy (DE-APSO-PS) is validated on three large practical test systems. - Abstract: This paper introduces an efficient planning strategy using new hybrid interactive differential evolution (DE), adaptive particle swarm optimization (APSO), and pattern search (PS) for solving the security optimal power flow (SOPF) considering multi distributed static VAR compensator (SVC). Three objective functions such as fuel cost, power loss and voltage deviation are considered and optimized considering sever loading conditions. The main idea of the proposed strategy is that variable controls are optimized based on superposition mechanism, the best solutions evaluated by DE and APSO at specified stages are communicated to PS to exploit new regions around this solution, alternatively the new solution achieved by PS is also communicated to DE and APSO, this interactive mechanism search between global and local search is to balance the exploitation and exploration capability which allows individuals from different methods to react more by learning and changing experiences. The robustness of the proposed strategy is tested and validated on large practical power system test (IEEE 118-Bus, IEEE 300-Bus, and 40 units). Comparison results with the standard global optimization methods such as DE, APSO PS and to other recent techniques showed the superiority and perspective of the proposed hybrid technique for solving practical power system problems

Annihilation probability density and other applications of the Schwinger multichannel method to the positron and electron scattering; Densidade de probabilidade de aniquilacao e outras aplicacoes do metodo multicanal de Schwinger ao espalhamento de positrons e eletrons

Energy Technology Data Exchange (ETDEWEB)

Varella, Marcio Teixeira do Nascimento

2001-12-15

We have calculated annihilation probability densities (APD) for positron collisions against He atom and H{sub 2} molecule. It was found that direct annihilation prevails at low energies, while annihilation following virtual positronium (Ps) formation is the dominant mechanism at higher energies. In room-temperature collisions (10{sup -2} eV) the APD spread over a considerable extension, being quite similar to the electronic densities of the targets. The capture of the positron in an electronic Feshbach resonance strongly enhanced the annihilation rate in e{sup +}-H{sub 2} collisions. We also discuss strategies to improve the calculation of the annihilation parameter (Z{sub eff} ), after debugging the computational codes of the Schwinger Multichannel Method (SMC). Finally, we consider the inclusion of the Ps formation channel in the SMC and show that effective configurations (pseudo eigenstates of the Hamiltonian of the collision ) are able to significantly reduce the computational effort in positron scattering calculations. Cross sections for electron scattering by polyatomic molecules were obtained in three different approximations: static-exchange (SE); tatic-exchange-plus-polarization (SEP); and multichannel coupling. The calculations for polar targets were improved through the rotational resolution of scattering amplitudes in which the SMC was combined with the first Born approximation (FBA). In general, elastic cross sections (SE and SEP approximations) showed good agreement with available experimental data for several targets. Multichannel calculations for e{sup -} -H{sub 2}O scattering, on the other hand, presented spurious structures at the electronic excitation thresholds (author)

Globally Optimal Segmentation of Permanent-Magnet Systems

DEFF Research Database (Denmark)

Insinga, Andrea Roberto; Bjørk, Rasmus; Smith, Anders

2016-01-01

Permanent-magnet systems are widely used for generation of magnetic fields with specific properties. The reciprocity theorem, an energy-equivalence principle in magnetostatics, can be employed to calculate the optimal remanent flux density of the permanent-magnet system, given any objective...... remains unsolved. We show that the problem of optimal segmentation of a two-dimensional permanent-magnet assembly with respect to a linear objective functional can be reduced to the problem of piecewise linear approximation of a plane curve by perimeter maximization. Once the problem has been cast...

Long-term Culture of Human iPS Cell-derived Telencephalic Neuron Aggregates on Collagen Gel.

Science.gov (United States)

Oyama, Hiroshi; Takahashi, Koji; Tanaka, Yoshikazu; Takemoto, Hiroshi; Haga, Hisashi

2018-01-01

It takes several months to form the 3-dimensional morphology of the human embryonic brain. Therefore, establishing a long-term culture method for neuronal tissues derived from human induced pluripotent stem (iPS) cells is very important for studying human brain development. However, it is difficult to keep primary neurons alive for more than 3 weeks in culture. Moreover, long-term adherent culture to maintain the morphology of telencephalic neuron aggregates induced from human iPS cells is also difficult. Although collagen gel has been widely used to support long-term culture of cells, it is not clear whether human iPS cell-derived neuron aggregates can be cultured for long periods on this substrate. In the present study, we differentiated human iPS cells to telencephalic neuron aggregates and examined long-term culture of these aggregates on collagen gel. The results indicated that these aggregates could be cultured for over 3 months by adhering tightly onto collagen gel. Furthermore, telencephalic neuronal precursors within these aggregates matured over time and formed layered structures. Thus, long-term culture of telencephalic neuron aggregates derived from human iPS cells on collagen gel would be useful for studying human cerebral cortex development.Key words: Induced pluripotent stem cell, forebrain neuron, collagen gel, long-term culture.

Object permanence in adults : a cross-cultural perspective

OpenAIRE

Subbotski, Eugene; Trommsdorff, Gisela

1992-01-01

Soviet and German adult subjects observed the phenomenon of object non-permanence (destruction, reconstruction, or transformation of a physical object). Both samples attributed an equal degree of probability to real existence of object non-permanence. However, Soviet subjects attributed a significantly higher probability to the existence of "religion-independent" non-permanent mysterious phenomena, (e.g., "unidentified flying objects", "abominable snowman", "Loch Ness monster") while attribut...

Generation of magnetic fields for accelerators with permanent magnets

International Nuclear Information System (INIS)

Meinander, T.

1994-01-01

Commercially available permanent magnet materials and their properties are reviewed. Advantages and disadvantages of using permanent magnets as compared to electromagnets for the generation of specific magnetic fields are discussed. Basic permanent magnet configurations in multipole magnets and insertion devices are presented. (orig.)

Transfer line from the PSB to the PS (recombination)

CERN Multimedia

CERN PhotoLab

1976-01-01

After sequential ejection of 5 bunches from each of the 4 rings of the Booster (originally 800 MeV, now 1.4 GeV), the 4 batches are brought to the same vertical level, so as to form a string of 20 bunches, filling the circumference of the PS. This vertical "recombination" is performed in the transfer line, using vertical bending magnets, septa and kickers. Here we see the section where the beam from ring 4 (the top one) is brought down to the level of ring 3, and the beam from ring 1 up to the level of ring 2. Further downstream (to the right, outside this picture), level 2 is brought up to level 3, identical to that of the PS. After this original recombination scheme, other ways of combining the 4 beams, vertically and/or longitudinally, were developed and used in operation.

Images of Christ's Saving Work in Ps.-Epiphanius' Homilies

Directory of Open Access Journals (Sweden)

H. F. Stander

1997-12-01

Full Text Available Images of Christ's Saving Work in Ps.-Epiphanius' Homilies. One cannot really speak of a systematic theology on the subject of atone-ment in the patristic writers. Frances Young once said that 'it is in fact impossible to categorize neatly the thought of the major patristic writers on the subject of atonement'. She adds that one cannot do justice to the range of motifs and images that are found in describing the saving and atoning work of Christ if we merely dismember 'systematic theologies' to illustrate common soteriological themes. One can only appreciate patristic views of atonement if one begins by recognizing the multifaceted unity of imagery that pervades the literature. This then is the goal of this article: to discuss the rich images which Ps: -Epiphanius uses to describe the atoning work of Christ.

Non-viral generation of marmoset monkey iPS cells by a six-factor-in-one-vector approach.

Science.gov (United States)

Debowski, Katharina; Warthemann, Rita; Lentes, Jana; Salinas-Riester, Gabriela; Dressel, Ralf; Langenstroth, Daniel; Gromoll, Jörg; Sasaki, Erika; Behr, Rüdiger

2015-01-01

Groundbreaking studies showed that differentiated somatic cells of mouse and human origin could be reverted to a stable pluripotent state by the ectopic expression of only four proteins. The resulting pluripotent cells, called induced pluripotent stem (iPS) cells, could be an alternative to embryonic stem cells, which are under continuous ethical debate. Hence, iPS cell-derived functional cells such as neurons may become the key for an effective treatment of currently incurable degenerative diseases. However, besides the requirement of efficacy testing of the therapy also its long-term safety needs to be carefully evaluated in settings mirroring the clinical situation in an optimal way. In this context, we chose the long-lived common marmoset monkey (Callithrix jacchus) as a non-human primate species to generate iPS cells. The marmoset monkey is frequently used in biomedical research and is gaining more and more preclinical relevance due to the increasing number of disease models. Here, we describe, to our knowledge, the first-time generation of marmoset monkey iPS cells from postnatal skin fibroblasts by non-viral means. We used the transposon-based, fully reversible piggyback system. We cloned the marmoset monkey reprogramming factors and established robust and reproducible reprogramming protocols with a six-factor-in-one-construct approach. We generated six individual iPS cell lines and characterized them in comparison with marmoset monkey embryonic stem cells. The generated iPS cells are morphologically indistinguishable from marmoset ES cells. The iPS cells are fully reprogrammed as demonstrated by differentiation assays, pluripotency marker expression and transcriptome analysis. They are stable for numerous passages (more than 80) and exhibit euploidy. In summary, we have established efficient non-viral reprogramming protocols for the derivation of stable marmoset monkey iPS cells, which can be used to develop and test cell replacement therapies in

Non-viral generation of marmoset monkey iPS cells by a six-factor-in-one-vector approach.

Directory of Open Access Journals (Sweden)

Katharina Debowski

Full Text Available Groundbreaking studies showed that differentiated somatic cells of mouse and human origin could be reverted to a stable pluripotent state by the ectopic expression of only four proteins. The resulting pluripotent cells, called induced pluripotent stem (iPS cells, could be an alternative to embryonic stem cells, which are under continuous ethical debate. Hence, iPS cell-derived functional cells such as neurons may become the key for an effective treatment of currently incurable degenerative diseases. However, besides the requirement of efficacy testing of the therapy also its long-term safety needs to be carefully evaluated in settings mirroring the clinical situation in an optimal way. In this context, we chose the long-lived common marmoset monkey (Callithrix jacchus as a non-human primate species to generate iPS cells. The marmoset monkey is frequently used in biomedical research and is gaining more and more preclinical relevance due to the increasing number of disease models. Here, we describe, to our knowledge, the first-time generation of marmoset monkey iPS cells from postnatal skin fibroblasts by non-viral means. We used the transposon-based, fully reversible piggyback system. We cloned the marmoset monkey reprogramming factors and established robust and reproducible reprogramming protocols with a six-factor-in-one-construct approach. We generated six individual iPS cell lines and characterized them in comparison with marmoset monkey embryonic stem cells. The generated iPS cells are morphologically indistinguishable from marmoset ES cells. The iPS cells are fully reprogrammed as demonstrated by differentiation assays, pluripotency marker expression and transcriptome analysis. They are stable for numerous passages (more than 80 and exhibit euploidy. In summary, we have established efficient non-viral reprogramming protocols for the derivation of stable marmoset monkey iPS cells, which can be used to develop and test cell replacement

Effect of Grafting Density of Random Copolymer Brushes on Perpendicular Alignment in PS-b-PMMA Thin Films

KAUST Repository

Lee, Wooseop; Park, Sungmin; Kim, Yeongsik; Sethuraman, Vaidyanathan; Rebello, Nathan; Ganesan, Venkat; Ryu, Du Yeol

2017-01-01

We modulated the grafting density (σ) of a random copolymer brush of poly(styrene-r-methyl methacrylate) on substrates to probe its effect on the formation of perpendicularly aligned lamellae of polystyrene-b-poly(methyl methacrylate) (PS-b-PMMA). Supported by coarse-grained simulation results, we hypothesized that an increase in σ will allow us to systematically tune the block copolymer interfacial interactions with the substrates from being preferential to one of the blocks to being neutral toward both blocks and will thereby facilitate enhanced regimes of perpendicularly aligned lamellae. We verified such a hypothesis by using a simple grafting-to approach to modify the substrates and characterized the thickness window for perpendicular lamellae as a function of brush thickness (or σ) on the grafted substrates using scanning force microscopy (SFM) images and grazing incidence small-angle X-ray scattering (GISAXS) measurements. The experimental results validated our hypothesis and suggested that the σ of random copolymer brushes can be used as an additional versatile parameter to modulate the interfacial interactions and the resulting alignment of block copolymer films.

Effect of Grafting Density of Random Copolymer Brushes on Perpendicular Alignment in PS-b-PMMA Thin Films

KAUST Repository

Lee, Wooseop

2017-07-18

We modulated the grafting density (σ) of a random copolymer brush of poly(styrene-r-methyl methacrylate) on substrates to probe its effect on the formation of perpendicularly aligned lamellae of polystyrene-b-poly(methyl methacrylate) (PS-b-PMMA). Supported by coarse-grained simulation results, we hypothesized that an increase in σ will allow us to systematically tune the block copolymer interfacial interactions with the substrates from being preferential to one of the blocks to being neutral toward both blocks and will thereby facilitate enhanced regimes of perpendicularly aligned lamellae. We verified such a hypothesis by using a simple grafting-to approach to modify the substrates and characterized the thickness window for perpendicular lamellae as a function of brush thickness (or σ) on the grafted substrates using scanning force microscopy (SFM) images and grazing incidence small-angle X-ray scattering (GISAXS) measurements. The experimental results validated our hypothesis and suggested that the σ of random copolymer brushes can be used as an additional versatile parameter to modulate the interfacial interactions and the resulting alignment of block copolymer films.

Status of the anti-proton production beam in the CERN PS

International Nuclear Information System (INIS)

Cappi, R.; Evans, B.J.; Garoby, R.

1990-01-01

A new scheme was put into operation in November 1988 to upgrade the proton beam delivered by the 26 GeV Proton Synchrotron (PS) for anti-proton production. It makes use of quasi-adiabatic manipulations of the RF parameters to squeeze a beam filling 1/2 of the PS circumference into a 1/4 turn and can in theory preserve the longitudinal emittance. A maximum intensity of 1.68 e 13 ppp in 5 bunches at 26 GeV has been reached in the course of 22 weeks of operation. The limitations of the performance are analysed together with possible improvements. (author) 6 refs., 9 figs

Microproteins (miPs – the next big thing

Directory of Open Access Journals (Sweden)

Feller Stephan

2012-12-01

Full Text Available Abstract With iPS cells, sncRNAs, chromatin modification regulation and cancer stem cells already cooling off again, i.e. not being guaranteed publications in the 'ultimate' journals anymore, what will be very soon the new red-hot (or super-cool, i.e. anything but lukewarm 'kid on the block'? We would vote for microproteins.

Dovetail spoke internal permanent magnet machine

Science.gov (United States)

Alexander, James Pellegrino [Ballston Lake, NY; EL-Refaie, Ayman Mohamed Fawzi [Niskayuna, NY; Lokhandwalla, Murtuza [Clifton Park, NY; Shah, Manoj Ramprasad [Latham, NY; VanDam, Jeremy Daniel [West Coxsackie, NY

2011-08-23

An internal permanent magnet (IPM) machine is provided. The IPM machine includes a stator assembly and a stator core. The stator core also includes multiple stator teeth. The stator assembly is further configured with stator windings to generate a stator magnetic field when excited with alternating currents and extends along a longitudinal axis with an inner surface defining a cavity. The IPM machine also includes a rotor assembly and a rotor core. The rotor core is disposed inside the cavity and configured to rotate about the longitudinal axis. The rotor assembly further includes a shaft. The shaft further includes multiple protrusions alternately arranged relative to multiple bottom structures provided on the shaft. The rotor assembly also includes multiple stacks of laminations disposed on the protrusions and dovetailed circumferentially around the shaft. The rotor assembly further includes multiple pair of permanent magnets for generating a magnetic field, which magnetic field interacts with the stator magnetic field to produce a torque. The multiple pair of permanent magnets are disposed between the stacks. The rotor assembly also includes multiple middle wedges mounted between each pair of the multiple permanent magnets.

Permanent Magnet Eddy Current Loss Analysis of a Novel Motor Integrated Permanent Magnet Gear

DEFF Research Database (Denmark)

Zhang, Yuqiu; Lu, Kaiyuan; Ye, Yunyue

2012-01-01

In this paper, a new motor integrated permanent magnet gear (MIPMG) is discussed. The focus is on eddy current loss analysis associated to permanent magnets (PMs). A convenient model of MIPMG is provided based on 2-D field-motion coupled time-stepping finite element method for transient eddy...... current analysis. The model takes the eddy current effect of PMs into account in determination of the magnetic field in the air-gap and in the magnet regions. The eddy current losses generated in the magnets are properly interpreted. Design improvements for reducing the eddy current losses are suggested...

Psühhofüsioloogilised mängud / Kaivo Thomson

Index Scriptorium Estoniae

Thomson, Kaivo, 1956-

2002-01-01

Rmt.: Thomson, Kaivo. Psühhofüsioloogilised mängud : teooria & värvitoonide, helikõrguste ja liikumiskiiruste eristamisvõime testimine ning arendamine meetodiga "WinPsycho 2000" (CD-1). Tartu : Atlex, 2001.

Thermal Processing Effects on the Adhesive Strength of PS304 High Temperature Solid Lubricant Coatings

Science.gov (United States)

DellaCorte, Christopher; Edmonds, Brian J.; Benoy, Patricia A.

2001-01-01

In this paper the effects of post deposition heat treatments on the cohesive and adhesive strength properties of PS304, a plasma sprayed nickel-chrome based, high temperature solid lubricant coating deposited on stainless steel, are studied. Plasma spray deposited coating samples were exposed in air at temperatures from 432 to 650 C for up to 500 hr to promote residual stress relief, enhance particle to particle bonding and increase coating to substrate bond strength. Coating pull-off strength was measured using a commercial adhesion tester that utilizes 13 mm diameter aluminum pull studs attached to the coating surface with epoxy. Pull off force was automatically recorded and converted to coating pull off strength. As deposited coating samples were also tested as a baseline. The as-deposited (untreated) samples either delaminated at the coating-substrate interface or failed internally (cohesive failure) at about 17 MPa. Samples heat treated at temperatures above 540 C for 100 hr or at 600 C or above for more than 24 hr exhibited strengths above 31 MPa, nearly a two fold increase. Coating failure occurred inside the body of the coating (cohesive failure) for nearly all of the heat-treated samples and only occasionally at the coating substrate interface (adhesive failure). Metallographic analyses of heat-treated coatings indicate that the Nickel-Chromium binder in the PS304 appears to have segregated into two phases, a high nickel matrix phase and a high chromium precipitated phase. Analysis of the precipitates indicates the presence of silicon, a constituent of a flow enhancing additive in the commercial NiCr powder. The exact nature and structure of the precipitate phase is not known. This microstructural change is believed to be partially responsible for the coating strength increase. Diffusion bonding between particles may also be playing a role. Increasing the heat treatment temperature, exposure time or both accelerate the heat treatment process. Preliminary

Permanent isolation surface barrier development plan

International Nuclear Information System (INIS)

Wing, N.R.

1994-01-01

The exhumation and treatment of wastes may not always be the preferred alternative in the remediation of a waste site. In-place disposal alternatives, under certain circumstances, may be the most desirable alternatives to use in the protection of human health and the environment. The implementation of an in-place disposal alternative will likely require some type of protective covering that will provide long-term isolation of the wastes from the accessible environment. Even if the wastes are exhumed and treated, a long-term barrier may still be needed to adequately dispose of the treated wastes or any remaining waste residuals. Currently, no open-quotes provenclose quotes long-term barrier is available. The Hanford Site Permanent Isolation Surface Barrier Development Program (BDP) was organized to develop the technology needed to provide a long-term surface barrier capability for the Hanford Site. The permanent isolation barrier technology also could be used at other sites. Permanent isolation barriers use engineered layers of natural materials to create an integrated structure with redundant protective features. Drawings of conceptual permanent isolation surface barriers are shown. The natural construction materials (e.g., fine soil, sand, gravel, riprap, asphalt) have been selected to optimize barrier performance and longevity. The objective of current designs is to use natural materials to develop a maintenance-free permanent isolation surface barrier that isolates wastes for a minimum of 1,000 years by limiting water drainage to near-zero amounts; reducing the likelihood of plant, animal, and human intrusion; controlling the exhalation of noxious gases; and minimizing erosion-related problems

Permanent isolation surface barrier development plan

Energy Technology Data Exchange (ETDEWEB)

Wing, N.R.

1994-01-01

The exhumation and treatment of wastes may not always be the preferred alternative in the remediation of a waste site. In-place disposal alternatives, under certain circumstances, may be the most desirable alternatives to use in the protection of human health and the environment. The implementation of an in-place disposal alternative will likely require some type of protective covering that will provide long-term isolation of the wastes from the accessible environment. Even if the wastes are exhumed and treated, a long-term barrier may still be needed to adequately dispose of the treated wastes or any remaining waste residuals. Currently, no {open_quotes}proven{close_quotes} long-term barrier is available. The Hanford Site Permanent Isolation Surface Barrier Development Program (BDP) was organized to develop the technology needed to provide a long-term surface barrier capability for the Hanford Site. The permanent isolation barrier technology also could be used at other sites. Permanent isolation barriers use engineered layers of natural materials to create an integrated structure with redundant protective features. Drawings of conceptual permanent isolation surface barriers are shown. The natural construction materials (e.g., fine soil, sand, gravel, riprap, asphalt) have been selected to optimize barrier performance and longevity. The objective of current designs is to use natural materials to develop a maintenance-free permanent isolation surface barrier that isolates wastes for a minimum of 1,000 years by limiting water drainage to near-zero amounts; reducing the likelihood of plant, animal, and human intrusion; controlling the exhalation of noxious gases; and minimizing erosion-related problems.

Adjustable permanent magnet assembly for NMR and MRI

Science.gov (United States)

Pines, Alexander; Paulsen, Jeffrey; Bouchard, Louis S; Blumich, Bernhard

2013-10-29

System and methods for designing and using single-sided magnet assemblies for magnetic resonance imaging (MRI) are disclosed. The single-sided magnet assemblies can include an array of permanent magnets disposed at selected positions. At least one of the permanent magnets can be configured to rotate about an axis of rotation in the range of at least +/-10 degrees and can include a magnetization having a vector component perpendicular to the axis of rotation. The single-sided magnet assemblies can further include a magnet frame that is configured to hold the permanent magnets in place while allowing the at least one of the permanent magnets to rotate about the axis of rotation.

Method and apparatus for assembling permanent magnet rotors

Science.gov (United States)

Hsu, J.S.; Adams, D.J.

1999-06-22

A permanent magnet assembly for assembly in large permanent magnet motors and generators includes a two-piece carrier that can be slid into a slot in the rotor and then secured in place using a set screw. The invention also provides an auxiliary carrier device with guide rails that line up with the teeth of the rotor, so that a permanent magnet assembly can be pushed first into a slot, and then down the slot to its proper location. An auxiliary tool is provided to move the permanent magnet assembly into position in the slot before it is secured in place. Methods of assembling and disassembling the magnet assemblies in the rotor are also disclosed. 2 figs.

Induction of host defences by Rhizobium during ineffective nodulation of pea (Pisum sativum L.) carrying symbiotically defective mutations sym40 (PsEFD), sym33 (PsIPD3/PsCYCLOPS) and sym42.

Science.gov (United States)

Ivanova, Kira A; Tsyganova, Anna V; Brewin, Nicholas J; Tikhonovich, Igor A; Tsyganov, Viktor E

2015-11-01

Rhizobia are able to establish a beneficial interaction with legumes by forming a new organ, called the symbiotic root nodule, which is a unique ecological niche for rhizobial nitrogen fixation. Rhizobial infection has many similarities with pathogenic infection and induction of defence responses accompanies both interactions, but defence responses are induced to a lesser extent during rhizobial infection. However, strong defence responses may result from incompatible interactions between legumes and rhizobia due to a mutation in either macro- or microsymbiont. The aim of this research was to analyse different plant defence reactions in response to Rhizobium infection for several pea (Pisum sativum) mutants that result in ineffective symbiosis. Pea mutants were examined by histochemical and immunocytochemical analyses, light, fluorescence and transmission electron microscopy and quantitative real-time PCR gene expression analysis. It was observed that mutations in pea symbiotic genes sym33 (PsIPD3/PsCYCLOPS encoding a transcriptional factor) and sym40 (PsEFD encoding a putative negative regulator of the cytokinin response) led to suberin depositions in ineffective nodules, and in the sym42 there were callose depositions in infection thread (IT) and host cell walls. The increase in deposition of unesterified pectin in IT walls was observed for mutants in the sym33 and sym42; for mutant in the sym42, unesterified pectin was also found around degrading bacteroids. In mutants in the genes sym33 and sym40, an increase in the expression level of a gene encoding peroxidase was observed. In the genes sym40 and sym42, an increase in the expression levels of genes encoding a marker of hypersensitive reaction and PR10 protein was demonstrated. Thus, a range of plant defence responses like suberisation, callose and unesterified pectin deposition as well as activation of defence genes can be triggered by different pea single mutations that cause perception of an otherwise

Corporate Policies with Permanent and Transitory Shocks

NARCIS (Netherlands)

J-P. Decamps (Jean-Paul); S. Gryglewicz (Sebastian); E. Morellec (Erwan); S. Villeneuve (Stephane)

2016-01-01

textabstractWe model the financing, cash holdings, and hedging policies of a firm facing financing frictions and subject to permanent and transitory cash flow shocks. We show that permanent and transitory shocks generate distinct, sometimes opposite, effects on corporate policies and use the model

Supramolecular Assembly of Gold Nanoparticles in PS-b-P2VP Diblock Copolymers via Hydrogen Bonding

Science.gov (United States)

Jang, Se Gyu; Hawker, Craig J.; Kramer, Edward J.

2011-03-01

We report a simple route to control the spatial distribution of Au nanoparticles (Au-NPs) in PS- b -P2VP diblock copolymers using hydrogen bonding between P2VP and the hydroxyl-containing (PI-OH) units in PS- b -PIOH thiol-terminated ligands on Au-NP. End-functional thiol ligands of poly(styrene- b -1,2&3,4-isoprene-SH) are synthesized by anionic polymerization. After synthesis of Au-NPs, the inner PI block is hydroxylated by hydroboration and the resulting micelle-like Au-NPs consist of a hydrophobic PS outer brush and a hydrophilic inner PI-OH block. The influence of the hydroxyl groups is significant with strong segregation being observed to the PS/P2VP interface and then to the P2VP domain of lamellar-forming PS-b-P2VP diblock copolymers as the length of the PI-OH block is increased. The strong hydrogen bonding between nanoparticle block copolymer ligands and the P2VP block allows the Au-NPs to be incorporated within the P2VP domain to high Au--NP volume fractions ϕp without macrophase separation, driving transitions from lamellar to bicontinuous morphologies as ϕp increases.

Connecting Temporary and Permanent Organizing

DEFF Research Database (Denmark)

Stjerne, Iben Sandal; Velikova, Silviya Svejenova

2016-01-01

This paper investigates the relationship between a permanent organization and a series of temporary organizations. It draws on an in-depth study of the process through which a Danish film production company, seeking to balance innovation and persistence in a troubled industry, struggles to realize...... a novel children’s film and its sequels. The study reveals tensions at different levels as well as boundary work and boundary roles that address them, bringing in shadows of past and future projects. The study extends the understanding of the dialectic between temporary and permanent organizing...

Magnetization transfer contrast imaging detects early white matter changes in the APP/PS1 amyloidosis mouse model

Directory of Open Access Journals (Sweden)

Jelle Praet

2016-01-01

Full Text Available While no definitive cure for Alzheimer's disease exists yet, currently available treatments would benefit greatly from an earlier diagnosis. It has previously been shown that Magnetization transfer contrast (MTC imaging is able to detect amyloid β plaques in old APP/PS1 mice. In the current study we investigated if MTC is also able to visualize early amyloid β (Aβ induced pathological changes. In a cross-sectional study, a comparison was made between the MT ratio of wild type (WT and APP/PS1 mice at 2, 4, 6, 8 and 24 months of age. We observed an increased MT-ratio in the cortex of 24 month old APP/PS1 mice as compared to WT mice. However, when comparing the MT-ratio of the cortex of WT mice with the MT-ratio of the APP/PS1 mice at 2, 4, 6 or 8 months of age, no significant changes could be observed. In contrast to the cortex, we consistently observed a decreased MT-ratio in the splenium of 4, 6 and 8 month old APP/PS1 mice as compared to age-matched WT mice. Lastly, the decreased MT-ratio in the splenium of APP/PS1 mice correlated to the Aβ plaque deposition, astrogliosis and microgliosis. This MT-ratio decrease did however not correlate to the myelin content. Combined, our results suggest that MTC is able to visualize early Aβ-induced changes in the splenium but not the cortex of APP/PS1 mice.

76 FR 35683 - Medicare Program; Conditions of Participation (CoPs) for Community Mental Health Centers

Science.gov (United States)

2011-06-17

... Community Mental Health Centers; Proposed Rule #0;#0;Federal Register / Vol. 76 , No. 117 / Friday June 17... (CoPs) for Community Mental Health Centers AGENCY: Centers for Medicare & Medicaid Services (CMS), HHS... participation (CoPs) that community mental health centers (CMHCs) would have to meet in order to participate in...

The history of permanent magnet materials

International Nuclear Information System (INIS)

Livingston, J.D.

1990-01-01

Permanent-magnet materials play a large and growing, but largely unseen, role in today's technology. Many common devices in the home and elsewhere, including appliances, computers and printers, contain permanent-magnet motors and actuators. The growth of applications for permanent magnets results in large part from the improvements in magnetic properties, which allow the engineer to design smaller, lighter and more efficient devices. The properties of the greatest technological interest are remanence, coercivity and maximum energy product. All are non-equilibrium and high structure-sensitive. Coercivity is particularly sensitive to microstructure, while remanence is sensitive to texture (crystallographic alignment). The energy product depends on both coercivity and remanence. The more than one hundredfold increase in the available energy product in this century, and the corresponding amount of magnet required for a specific application, are shown

6 CFR 7.29 - Documents of permanent historical value.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Documents of permanent historical value. 7.29... NATIONAL SECURITY INFORMATION Classified Information § 7.29 Documents of permanent historical value. The... contained in records determined to have permanent historical value under 44 U.S.C. 2107 before they are...

Mõned varased mõõtmised ja hindamised psühholoogias / Konstantin Ramul ; tõlk. Kenn Konstabel

Index Scriptorium Estoniae

Ramul, Konstantin, 1879-1975

2004-01-01

Varajaste psühholoogiliste mõõtmiste ja hinnangute kirjeldusi, mis on tehtud ajaloo jooksul mittepsühholoogide poolt ja mida ei tehtud psühholoogilise uurimistöö huvides. Varem ilmunud: American Psychologist, 1963, nr. 18 (10), lk. 653-659

Laced permanent magnet quadrupole drift tube magnets

International Nuclear Information System (INIS)

Feinberg, B.; Behrsing, G.U.; Halbach, K.; Marks, J.S.; Morrison, M.E.; Nelson, D.H.

1988-10-01

A laced permanent magnet quadrupole drift tube magnet has been constructed for a proof-of-principle test. The magnet is a conventional tape-wound quadrupole electromagnet, using iron pole- pieces, with the addition of permanent magnet material (neodymium iron) between the poles to reduce the effects of saturation. The iron is preloaded with magnetic flux generated by the permanent magnet material, resulting in an asymmetrical saturation curve. Since the polarity of the quadrupole magnets in a drift tube linac is not reversed we can take advantage of this asymmetrical saturation to provide greater focusing strength. The magnet configuration has been optimized and the vanadium permendur poles needed in a conventional quadrupole have been replaced with iron poles. The use of permanent magnet material has allowed us to increase the focusing strength of the magnet by about 20% over that of a conventional tape-wound quadrupole. Comparisons will be made between this magnet and the conventional tape-wound quadrupole. 3 refs., 5 figs

Micromagnetics of rare-earth efficient permanent magnets

Science.gov (United States)

Fischbacher, Johann; Kovacs, Alexander; Gusenbauer, Markus; Oezelt, Harald; Exl, Lukas; Bance, Simon; Schrefl, Thomas

2018-05-01

The development of permanent magnets containing less or no rare-earth elements is linked to profound knowledge of the coercivity mechanism. Prerequisites for a promising permanent magnet material are a high spontaneous magnetization and a sufficiently high magnetic anisotropy. In addition to the intrinsic magnetic properties the microstructure of the magnet plays a significant role in establishing coercivity. The influence of the microstructure on coercivity, remanence, and energy density product can be understood by using micromagnetic simulations. With advances in computer hardware and numerical methods, hysteresis curves of magnets can be computed quickly so that the simulations can readily provide guidance for the development of permanent magnets. The potential of rare-earth reduced and rare-earth free permanent magnets is investigated using micromagnetic simulations. The results show excellent hard magnetic properties can be achieved in grain boundary engineered NdFeB, rare-earth magnets with a ThMn12 structure, Co-based nano-wires, and L10-FeNi provided that the magnet’s microstructure is optimized.

Optical design of beam lines at the KEK-PS new experimental hall

International Nuclear Information System (INIS)

Tanaka, K.H.; Ieiri, M.; Noumi, H.; Minakawa, M.; Yamanoi, Y.; Kato, Y.; Ishii, H.; Suzuki, Y.; Takasaki, M.

1995-01-01

A new counter experimental hall [K.H. Tanaka et al., IEEE Trans. Magn. 28 (1992) 697] was designed and constructed at the KEK 12-GeV Proton Synchrotron (KEK-PS). The extracted proton beam from the KEK-PS is introduced to the new hall through the newly-prepared primary beam line, EP1, and hits two production targets in cascade. The upstream target provides secondary particles to the low momentum (0.4-0.6 GeV/c) separated beam line, K5, and the downstream target is connected to the medium momentum (0.6-2.0 GeV/c) separated beam line, K6. Several new ideas were employed in the beam optical designs of EP1, K5 and K6 in order to increase the number and the purity of the short-lived secondary particles, such as kaons and pions, under the limited energy and intensity of the primary protons provided by the KEK-PS. These new ideas are described in this paper as well as the first commissioning results. (orig.)

Variable Permanent Magnet Quadrupole

International Nuclear Information System (INIS)

Mihara, T.; Iwashita, Y.; Kyoto U.; Kumada, M.; NIRS, Chiba; Spencer, C.M.; SLAC

2007-01-01

A permanent magnet quadrupole (PMQ) is one of the candidates for the final focus lens in a linear collider. An over 120 T/m strong variable permanent magnet quadrupole is achieved by the introduction of saturated iron and a 'double ring structure'. A fabricated PMQ achieved 24 T integrated gradient with 20 mm bore diameter, 100 mm magnet diameter and 20 cm pole length. The strength of the PMQ is adjustable in 1.4 T steps, due to its 'double ring structure': the PMQ is split into two nested rings; the outer ring is sliced along the beam line into four parts and is rotated to change the strength. This paper describes the variable PMQ from fabrication to recent adjustments

U.S. Lawful Permanent Residents: Fiscal Year 2014

Data.gov (United States)

Department of Homeland Security — Lawful permanent residents (LPRs), also known as “green card” holders, are non-citizens who are lawfully authorized to live permanently within the United States.

Academic Training Lecture Regular Programme: Physics at the AD/PS/SPS

CERN Multimedia

2012-01-01

Physics at the AD/PS/SPS (1/4), by Lau Gatignon (CERN).   Monday, June 18, 2012 from 11:00 to 12:00 (Europe/Zurich) at CERN ( 222-R-001 - Filtration Plant )   Lecture 1: The CERN injector complex and beams for non-LHC physics. The various machines and beam lines in the CERN injector complex are presented, from the linacs to the SPS. Special emphasis is given to the beam lines at the PS and SPS machines: AD, North and East Areas, nTOF and CNGS and HiRadMad as well as the ion beams. A short outlook is given to possible future upgrades and projects.   More information here.  

The PsB glycoprotein complex is secreted as a preassembled precursor of the spore coat in Dictyostelium discoideum.

Science.gov (United States)

Watson, N; McGuire, V; Alexander, S

1994-09-01

The PsB glycoprotein in Dictyostelium discoideum is one of a diverse group of developmentally regulated, prespore-cell-specific proteins, that contain a common O-linked oligosaccharide. This post-translational modification is dependent on the wild-type modB allele. The PsB protein exists as part of a multiprotein complex of six different proteins, which have different post-translational modifications and are held together by both covalent and non-covalent interactions (Watson et al. (1993). J. Biol. Chem. 268, 22634-22641). In this study we have used microscopic and biochemical analyses to examine the cellular localization and function of the PsB complex during development. We found that the PsB complex first accumulates in prespore vesicles in slug cells and is secreted later during culmination and becomes localized to both the extracellular matrix of the apical spore mass of mature fruiting bodies and to the inner layer of the spore coat. The PsB associated with the spore coat is covalently bound by disulfide bridges. The PsB protein always exists in a multiprotein complex, but the composition of the PsB complex changes during secretion and spore maturation. Some of the PsB complex proteins have been identified as spore coat proteins. These data demonstrate that some of the proteins that form the spore coat exist as a preassembled precursor complex. The PsB complex is secreted in a developmentally regulated manner during the process of spore differentiation, at which time proteins of the complex, as well as additional spore coat proteins, become covalently associated in at least two forms of extracellular matrix: the interspore matrix and the spore coat. These and other studies show that proteins with modB dependent O-linked oligosaccharides are involved in a wide variety of processes underlying morphogenesis in this organism. These developmental processes are the direct result of cellular mechanisms regulating protein targeting, assembly and secretion, and the

U.S. Lawful Permanent Residents: Fiscal Year 2013

Data.gov (United States)

Department of Homeland Security — A lawful permanent resident (LPR) or 'green card' recipient is defined by immigration law as a person who has been granted lawful permanent residence in the United...

OAS :: Authorities : Permanent Representatives to the OAS

Science.gov (United States)

Rights Actions against Corruption C Children Civil Registry Civil Society Contact Us Culture Cyber Representative of Belize Diego Pary Rodríguez Bolivia Diego Pary Rodríguez Ambassador, Permanent Representative of Bolivia José Luiz Machado Brazil José Luiz Machado e Costa Ambassador, Permanent Representative

PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus.

LENUS (Irish Health Repository)

Bowes, John

2015-04-28

Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis; it has a higher estimated genetic component than psoriasis alone, however most genetic susceptibility loci identified for PsA to date are also shared with psoriasis. Here we attempt to validate novel single nucleotide polymorphisms selected from our recent PsA Immunochip study and determine specificity to PsA.

GP pain management: what are the 'Ps' and 'As' of pain management?

Science.gov (United States)

Wan, Aston

2014-08-01

Pain is one common reason for clinical encounters in primary care. The complex nature of chronic pain syndromes can make assessment and management daunting at times. This article presents an easy scheme to help general practitioners efficiently assess, manage and review/follow up patients with chronic pain. The mnemonic presented for assessment is the '4Ps' (pain, other pathology/past medical history, performance/function and psychological/psychiatric status). For management, we can also use '4Ps' (physical, psychological, pharmacological and procedural) and for review there are the '6As' (activities, analgesia, adverse effects, aberrance behaviours, affects and adequate documentation).

Optical diagnostic suite (schlieren, interferometry, and grid image refractometry) on OMEGA EP using a 10-ps, 263-nm probe beama)

Science.gov (United States)

Froula, D. H.; Boni, R.; Bedzyk, M.; Craxton, R. S.; Ehrne, F.; Ivancic, S.; Jungquist, R.; Shoup, M. J.; Theobald, W.; Weiner, D.; Kugland, N. L.; Rushford, M. C.

2012-10-01

A 10-ps, 263-nm (4ω) laser is being built to probe plasmas produced on the OMEGA EP [J. H. Kelly, L. J. Waxer, V. Bagnoud, I. A. Begishev, J. Bromage, B. E. Kruschwitz, T. E. Kessler, S. J. Loucks, D. N. Maywar, R. L. McCrory et al., J. Phys. IV France 133, 75-80 (2006)], 10.1051/jp4:2006133015. A suite of optical diagnostics (schlieren, interferometry, and grid image refractometry) has been designed to diagnose and characterize a wide variety of plasmas. Light scattered by the probe beam is collected by an f/4 catadioptric telescope and a transport system is designed to image with a near-diffraction-limited resolution (˜1 - μm full width at half maximum) over a 5-mm field of view to a diagnostic table. The transport system provides a contrast greater than 1 : 104 with respect to all wavelengths outside of the 263 ± 2 nm measurement range.

Optical diagnostic suite (schlieren, interferometry, and grid image refractometry) on OMEGA EP using a 10-ps, 263-nm probe beam

Energy Technology Data Exchange (ETDEWEB)

Froula, D. H.; Boni, R.; Bedzyk, M.; Craxton, R. S.; Ehrne, F.; Ivancic, S.; Jungquist, R.; Shoup, M. J.; Theobald, W.; Weiner, D. [Laboratory for Laser Energetics, University of Rochester, 250 E. River Rd., Rochester, New York 14616 (United States); Kugland, N. L.; Rushford, M. C. [Lawrence Livermore National Laboratory, University of California, P. O. Box 808, Livermore, California 94551 (United States)

2012-10-15

A 10-ps, 263-nm (4{omega}) laser is being built to probe plasmas produced on the OMEGA EP [J. H. Kelly, L. J. Waxer, V. Bagnoud, I. A. Begishev, J. Bromage, B. E. Kruschwitz, T. E. Kessler, S. J. Loucks, D. N. Maywar, R. L. McCrory et al., J. Phys. IV France 133, 75-80 (2006)]. A suite of optical diagnostics (schlieren, interferometry, and grid image refractometry) has been designed to diagnose and characterize a wide variety of plasmas. Light scattered by the probe beam is collected by an f/4 catadioptric telescope and a transport system is designed to image with a near-diffraction-limited resolution ({approx}1 -{mu}m full width at half maximum) over a 5-mm field of view to a diagnostic table. The transport system provides a contrast greater than 1 : 10{sup 4} with respect to all wavelengths outside of the 263 {+-} 2 nm measurement range.

Optical diagnostic suite (schlieren, interferometry, and grid image refractometry) on OMEGA EP using a 10-ps, 263-nm probe beam.

Science.gov (United States)

Froula, D H; Boni, R; Bedzyk, M; Craxton, R S; Ehrne, F; Ivancic, S; Jungquist, R; Shoup, M J; Theobald, W; Weiner, D; Kugland, N L; Rushford, M C

2012-10-01

A 10-ps, 263-nm (4ω) laser is being built to probe plasmas produced on the OMEGA EP [J. H. Kelly, L. J. Waxer, V. Bagnoud, I. A. Begishev, J. Bromage, B. E. Kruschwitz, T. E. Kessler, S. J. Loucks, D. N. Maywar, R. L. McCrory et al., J. Phys. IV France 133, 75-80 (2006)]. A suite of optical diagnostics (schlieren, interferometry, and grid image refractometry) has been designed to diagnose and characterize a wide variety of plasmas. Light scattered by the probe beam is collected by an f/4 catadioptric telescope and a transport system is designed to image with a near-diffraction-limited resolution (~1 - μm full width at half maximum) over a 5-mm field of view to a diagnostic table. The transport system provides a contrast greater than 1 : 10(4) with respect to all wavelengths outside of the 263 ± 2 nm measurement range.

Optical diagnostic suite (schlieren, interferometry, and grid image refractometry) on OMEGA EP using a 10-ps, 263-nm probe beam

International Nuclear Information System (INIS)

Froula, D. H.; Boni, R.; Bedzyk, M.; Craxton, R. S.; Ehrne, F.; Ivancic, S.; Jungquist, R.; Shoup, M. J.; Theobald, W.; Weiner, D.; Kugland, N. L.; Rushford, M. C.

2012-01-01

A 10-ps, 263-nm (4ω) laser is being built to probe plasmas produced on the OMEGA EP [J. H. Kelly, L. J. Waxer, V. Bagnoud, I. A. Begishev, J. Bromage, B. E. Kruschwitz, T. E. Kessler, S. J. Loucks, D. N. Maywar, R. L. McCrory et al., J. Phys. IV France 133, 75–80 (2006)]. A suite of optical diagnostics (schlieren, interferometry, and grid image refractometry) has been designed to diagnose and characterize a wide variety of plasmas. Light scattered by the probe beam is collected by an f/4 catadioptric telescope and a transport system is designed to image with a near-diffraction-limited resolution (∼1 −μm full width at half maximum) over a 5-mm field of view to a diagnostic table. The transport system provides a contrast greater than 1 : 10 4 with respect to all wavelengths outside of the 263 ± 2 nm measurement range.

Space charge studies in the PS

CERN Document Server

Asvesta, F; Damerau, H; Huschauer, A; Papaphilippou, Y; Serluca, M; Sterbini, G; Zisopoulos, P

2017-01-01

In this paper the results of Machine Development (MD)studies conducted at the CERN Proton Sychrotron (PS) arepresented. The main focus was the investigation of newworking points in an effort to characterize and potentiallyimprove the brightness for LHC-type beams in view of theLHC Injectors Upgrade (LIU). Various working points werecompared in terms of losses and emittance evolution. Sincespace charge and the resonances it excites are the main causefor emittance blow-up and losses, tunes close to excitedresonances were carefully studied. Mitigation techniques,such as bunch flattening using a double harmonic RF system,were also tested.