[Construction of an educational technology for teaching about nursing on peripheral venipuncture].

Science.gov (United States)

Frota, Natasha Marques; Barros, Lívia Moreira; de Araújo, Thiago Moura; Caldini, Luana Nunes; do Nascimento, Jennara Cândido; Caetano, Joselany Afio

2013-06-01

The aim of the study was to describe the construction of a course on peripheral venipuncture using the Information and Communication Technologies. This is a methodological research, developed at the Federal University of Ceara from January to March 2012. The construction phases are: the analysis, design and development according to the theoretical framework of Galvis-Panqueva. In the analysis, objectives, content target audience, the study environment and technology infrastructure were delimited. During the design phase the environment interface and navigation structure of the course were evaluated. The development consisted in the materialization of all that was designed in the previous phase Once all three phases of construction of the course were conducted it was available in the Virtual Learning Environment SOLAR. The finalproduct of the course is presented as support of nursing students and consequently the training of future nurses in their care practice on peripheral venipuncture.

Information Architecture the Design of Digital Information Spaces

CERN Document Server

Ding, Wei

2009-01-01

Information Architecture is about organizing and simplifying information, designing and integrating information spaces/systems, and creating ways for people to find and interact with information content. Its goal is to help people understand and manage information and make right decisions accordingly. In the ever-changing social, organizational and technological contexts, Information Architects not only design individual information spaces (e.g., individual websites, software applications, and mobile devices), but also tackle strategic aggregation and integration of multiple information spaces

The stressed eyewitness: The interaction of thematic arousal and post-event stress in memory for central and peripheral event information

Directory of Open Access Journals (Sweden)

Gerald eEchterhoff

2012-08-01

Full Text Available Both arousal during the encoding of stimuli and subsequent stress can affect memory, often by increasing memory for important or central information. We explored whether event-based (thematic arousal and post-event stress interact to selectively enhance eyewitnesses’ memory for the central aspects of an observed incident. Specifically, we argue that memory for stimuli should be enhanced when (a the stimuli are encoded under arousal (vs. non-arousal, and (b stress is experienced soon after the encoding episode.We designed an experiment that extended previous research by manipulating arousal without changing the stimulus material, distinguishing between central and peripheral event information, and using a dynamic, life-like event instead of static pictures. After watching a video depicting a burglary under high or low thematic arousal, psychosocial stress was induced or not induced by the Trier Social Stress Test. Salivary cortisol was measured at standard intervals. Consistent with our prediction, we found a significant thematic arousal x post-event stress x centrality interaction, indicating that the recognition advantage for central event items over peripheral event items was most pronounced under both high thematic arousal and post-event stress. Because stress was induced after encoding this interaction cannot be explained by possible differences at encoding, such as narrowed attention. The centrality effect of post-event stress under high thematic arousal was statistically mediated by the cortisol increase, which suggests a key role of the stress hormone. We discuss implications of our findings for psychological and neuroscientific theories of emotional memory formation.

Processing and Memory of Central versus Peripheral Information as a Function of Reading Goals: Evidence from Eye-Movements

Science.gov (United States)

Yeari, Menahem; van den Broek, Paul; Oudega, Marja

2015-01-01

The present study examined the effect of reading goals on the processing and memory of central and peripheral textual information. Using eye-tracking methodology, we compared the effect of four common reading goals--entertainment, presentation, studying for a close-ended (multiple-choice) questions test, and studying for an open-ended questions…

Peripheral retinal nonperfusion associated with chronic myeloid leukemia.

NARCIS (Netherlands)

Nobacht, S.; Vandoninck, K.F.; Deutman, A.F.; Klevering, B.J.

2003-01-01

PURPOSE: To report a case of peripheral retinal nonperfusion and chronic myeloid leukemia in a 23-year-old woman. DESIGN: Observational case report. METHODS: A complete ophthalmic and systemic evaluation was performed. RESULTS: Ophthalmic examination revealed peripheral retinal nonperfusion with

Peripheral facial nerve dysfunction: CT evaluation

Energy Technology Data Exchange (ETDEWEB)

Disbro, M.A.; Harnsberger, H.R.; Osborn, A.G.

1985-06-01

Peripheral facial nerve dysfunction may have a clinically apparent or occult cause. The authors reviewed the clinical and radiographic records of 36 patients with peripheral facial nerve dysfunction to obtain information on the location of the suspected lesion and the number, sequence, and type of radiographic evaluations performed. Inadequate clinical evaluations before computed tomography (CT) was done and unnecessary CT examinations were also noted. They have suggested a practical clinical and radiographic scheme to evaluate progressive peripheral facial dysfunction with no apparent cause. If this scheme is applied, unnecessary radiologic tests and delays in diagnosis and treatment may be avoided.

Peripheral neuropathy

Science.gov (United States)

... peripheral; Neuritis - peripheral; Nerve disease; Polyneuropathy; Chronic pain - peripheral neuropathy ... Philadelphia, PA: Elsevier; 2016:chap 107. Shy ME. Peripheral neuropathies. In: Goldman L, Schafer AI, eds. Goldman's Cecil ...

Designing the visualization of information

CSIR Research Space (South Africa)

Engelbrecht, L

2015-04-01

Full Text Available The construction of an artifact to visually represent information is usually required by Information Visualization research projects. The end product of design science research is also an artifact and therefore it can be argued that design science...

Mini-review: Far peripheral vision.

Science.gov (United States)

Simpson, Michael J

2017-11-01

The region of far peripheral vision, beyond 60 degrees of visual angle, is important to the evaluation of peripheral dark shadows (negative dysphotopsia) seen by some intraocular lens (IOL) patients. Theoretical calculations show that the limited diameter of an IOL affects ray paths at large angles, leading to a dimming of the main image for small pupils, and to peripheral illumination by light bypassing the IOL for larger pupils. These effects are rarely bothersome, and cataract surgery is highly successful, but there is a need to improve the characterization of far peripheral vision, for both pseudophakic and phakic eyes. Perimetry is the main quantitative test, but the purpose is to evaluate pathologies rather than characterize vision (and object and image regions are no longer uniquely related in the pseudophakic eye). The maximum visual angle is approximately 105 0 , but there is limited information about variations with age, race, or refractive error (in case there is an unexpected link with the development of myopia), or about how clear cornea, iris location, and the limiting retina are related. Also, the detection of peripheral motion is widely recognized to be important, yet rarely evaluated. Overall, people rarely complain specifically about this visual region, but with "normal" vision including an IOL for >5% of people, and increasing interest in virtual reality and augmented reality, there are new reasons to characterize peripheral vision more completely. Copyright © 2017 Elsevier Ltd. All rights reserved.

Development of regenerative peripheral nerve interfaces for motor control of neuroprosthetic devices

Science.gov (United States)

Kemp, Stephen W. P.; Urbanchek, Melanie G.; Irwin, Zachary T.; Chestek, Cynthia A.; Cederna, Paul S.

2017-05-01

Traumatic peripheral nerve injuries suffered during amputation commonly results in debilitating neuropathic pain in the affected limb. Modern prosthetic technologies allow for intuitive, simultaneous control of multiple degrees of freedom. However, these state-of-the-art devices require separate, independent control signals for each degree of freedom, which is currently not possible. As a result, amputees reject up to 75% of myoelectric devices preferring instead to use body-powered artificial limbs which offer subtle sensory feedback. Without meaningful and intuitive sensory feedback, even the most advanced myoelectric prostheses remain insensate, burdensome, and are associated with enormous cognitive demand and mental fatigue. The ideal prosthetic device is one which is capable of providing intuitive somatosensory feedback essential for interaction with the environment. Critical to the design of such a bioprosthetic device is the development of a reliable biologic interface between human and machine. This ideal patient-prosthetic interface allows for transmission of both afferent somatosensory information and efferent motor signals for a closed-loop feedback system of neural control. Our lab has developed the Regenerative Peripheral Nerve Interface (RPNI) as a biologic nerve interface designed for stable integration of a prosthetic device with transected peripheral nerves in a residual limb. The RPNI is constructed by surgically implanting the distal end of a transected peripheral nerve into an autogenous muscle graft. Animal experiments in our lab have shown recording of motor signals from RPNI's implanted into both rodents and monkeys. Here, we achieve high amplitude EMG signals with a high signal to noise (SNR) ratio.

Information rich display design

International Nuclear Information System (INIS)

Welch, Robin; Braseth, Alf Ove; Veland, Oeystein

2004-01-01

This paper presents the concept Information Rich Displays. The purpose of Information Rich Displays (IRDs) is to condensate prevailing information in process displays in such a way that each display format (picture) contains more relevant information for the user. Compared to traditional process control displays, this new concept allows the operator to attain key information at a glance and at the same time allows for improved monitoring of larger portions of the process. This again allows for reduced navigation between both process and trend displays and ease the cognitive demand on the operator. This concept has been created while working on designing display prototypes for the offshore petroleum production facilities of tomorrow. Offshore installations basically consist of wells, separation trains (where oil, gas and water are separated from each other), an oil tax measurement system (where oil quality is measured and the pressure increased to allow for export), gas compression (compression of gas for export) and utility systems (water treatment, chemical systems etc.). This means that an offshore control room operator has to deal with a complex process that comprises several functionally different systems. The need for a new approach to offshore display format design is in particular based on shortcomings in today's designs related to the keyhole effect, where the display format only reveals a fraction of the whole process. Furthermore, the upcoming introduction of larger off- and on-shore operation centres will increase the size and complexity of the operators' work domain. In the light of the increased demands on the operator, the proposed IRDs aim to counter the negative effects this may have on the workload. In this work we have attempted to classify the wide range of different roles an operator can have in different situations. The information content and amount being presented to the operator in a display should be viewed in context of the roles the

The role of peripheral vision in implicit contextual cuing.

Science.gov (United States)

van Asselen, Marieke; Castelo-Branco, Miguel

2009-01-01

Implicit contextual cuing refers to the ability to learn the association between contextual information of our environment and a specific target, which can be used to guide attention during visual search. It was recently suggested that the storage of a snapshot image of the local context of a target underlies implicit contextual cuing. To make such a snapshot, it is necessary to use peripheral vision. In order to test whether peripheral vision can underlie implicit contextual cuing, we used a covert visual search task, in which participants were required to indicate the orientation of a target stimulus while foveating a fixation cross. The response times were shorter when the configuration of the stimuli was repeated than when the configuration was new. Importantly, this effect was still found after 10 days, indicating that peripherally perceived spatial context information can be stored in memory for long periods of time. These results indicate that peripheral vision can be used to make a snapshot of the local context of a target.

Nerve conduction and excitability studies in peripheral nerve disorders

DEFF Research Database (Denmark)

Krarup, Christian; Moldovan, Mihai

2009-01-01

counterparts in the peripheral nervous system, in some instances without peripheral nervous system symptoms. Both hereditary and acquired demyelinating neuropathies have been studied and the effects on nerve pathophysiology have been compared with degeneration and regeneration of axons. SUMMARY: Excitability......PURPOSE OF REVIEW: The review is aimed at providing information about the role of nerve excitability studies in peripheral nerve disorders. It has been known for many years that the insight into peripheral nerve pathophysiology provided by conventional nerve conduction studies is limited. Nerve...... excitability studies are relatively novel but are acquiring an increasingly important role in the study of peripheral nerves. RECENT FINDINGS: By measuring responses in nerve that are related to nodal function (strength-duration time constant, rheobase and recovery cycle) and internodal function (threshold...

Design and synthesis of elastin-like polypeptides for an ideal nerve conduit in peripheral nerve regeneration

International Nuclear Information System (INIS)

Hsueh, Yu-Sheng; Savitha, S.; Sadhasivam, S.; Lin, Feng-Huei; Shieh, Ming-Jium

2014-01-01

The study involves design and synthesis of three different elastin like polypeptide (ELP) gene monomers namely ELP1, ELP2 and ELP3 that encode for ELP proteins. The formed ELPs were assessed as an ideal nerve conduit for peripheral nerve regeneration. ELP1 was constructed with a small elongated pentapeptide carrying VPGVG sequence to mimic the natural polypeptide ELP. The ELP2 was designed by the incorporation of 4-penta peptide chains to improve the biocompatibility and mechanical strength. Thus, the third position in unique VPGVG was replaced with alanine to VPAVG and in a similar way modified to VPGKG, VPGEG and VPGIG with the substitution of lysine, glutamic acid and isoleucine. In ELP3, fibronectin C5 domain endowed with REDV sequence was introduced to improve the cell attachment. The ELP1, ELP2 and ELP3 proteins expressed by Escherichia coli were purified by inverse transition cycling (ITC). The purified ELPs were confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and western blotting. The Schwann cell (SC) morphology and cell adhesion were assessed by fabrication of ELP membrane cross-linked with glutaraledhyde. The Schwann cell proliferation was measured by WST-1 assay. Immunofluorostaining of Schwann cells was accomplished with SC specific phenotypic marker, S100. - Highlights: • Design and synthesis of three gene monomers of elastin like polypeptides (ELP1, 2 and 3) were reported. • Molecular weight of ITC purified ELP1, ELP2 and ELP3 was in the range of 37–38 kDa. • Schwann cell adhesion was found to be prominent in ELP3 and could be used as nerve conduit for peripheral nerve regeneration

Design and synthesis of elastin-like polypeptides for an ideal nerve conduit in peripheral nerve regeneration

Energy Technology Data Exchange (ETDEWEB)

Hsueh, Yu-Sheng [Institute of Biomedical Engineering, College of Engineering, National Taiwan University, Taipei 100, Taiwan (China); Institute of Biomedical Engineering, College of Medicine, National Taiwan University, Taipei 100, Taiwan (China); Savitha, S. [Institute of Biomedical Engineering, College of Engineering, National Taiwan University, Taipei 100, Taiwan (China); Department of Biotechnology, Sree Sastha Institute of Engineering and Technology, Chennai (India); Institute of Biomedical Engineering, College of Medicine, National Taiwan University, Taipei 100, Taiwan (China); Sadhasivam, S. [Division of Biomedical Engineering and Nanomedicine Research, National Health Research Institutes, Miaoli 350, Taiwan (China); Lin, Feng-Huei, E-mail: double@ntu.edu.tw [Institute of Biomedical Engineering, College of Engineering, National Taiwan University, Taipei 100, Taiwan (China); Division of Biomedical Engineering and Nanomedicine Research, National Health Research Institutes, Miaoli 350, Taiwan (China); Institute of Biomedical Engineering, College of Medicine, National Taiwan University, Taipei 100, Taiwan (China); Shieh, Ming-Jium [Institute of Biomedical Engineering, College of Engineering, National Taiwan University, Taipei 100, Taiwan (China); College of Medicine, National Taiwan University Hospital, Taipei 100, Taiwan (China); Institute of Biomedical Engineering, College of Medicine, National Taiwan University, Taipei 100, Taiwan (China)

2014-05-01

The study involves design and synthesis of three different elastin like polypeptide (ELP) gene monomers namely ELP1, ELP2 and ELP3 that encode for ELP proteins. The formed ELPs were assessed as an ideal nerve conduit for peripheral nerve regeneration. ELP1 was constructed with a small elongated pentapeptide carrying VPGVG sequence to mimic the natural polypeptide ELP. The ELP2 was designed by the incorporation of 4-penta peptide chains to improve the biocompatibility and mechanical strength. Thus, the third position in unique VPGVG was replaced with alanine to VPAVG and in a similar way modified to VPGKG, VPGEG and VPGIG with the substitution of lysine, glutamic acid and isoleucine. In ELP3, fibronectin C5 domain endowed with REDV sequence was introduced to improve the cell attachment. The ELP1, ELP2 and ELP3 proteins expressed by Escherichia coli were purified by inverse transition cycling (ITC). The purified ELPs were confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and western blotting. The Schwann cell (SC) morphology and cell adhesion were assessed by fabrication of ELP membrane cross-linked with glutaraledhyde. The Schwann cell proliferation was measured by WST-1 assay. Immunofluorostaining of Schwann cells was accomplished with SC specific phenotypic marker, S100. - Highlights: • Design and synthesis of three gene monomers of elastin like polypeptides (ELP1, 2 and 3) were reported. • Molecular weight of ITC purified ELP1, ELP2 and ELP3 was in the range of 37–38 kDa. • Schwann cell adhesion was found to be prominent in ELP3 and could be used as nerve conduit for peripheral nerve regeneration.

Risk informed life cycle plant design

International Nuclear Information System (INIS)

Hill, Ralph S. III; Nutt, Mark M.

2003-01-01

Many facility life cycle activities including design, construction, fabrication, inspection and maintenance are evolving from a deterministic to a risk-informed basis. The risk informed approach uses probabilistic methods to evaluate the contribution of individual system components to total system performance. Total system performance considers both safety and cost considerations including system failure, reliability, and availability. By necessity, a risk-informed approach considers both the component's life cycle and the life cycle of the system. In the nuclear industry, risk-informed approaches, namely probabilistic risk assessment (PRA) or probabilistic safety assessment (PSA), have become a standard tool used to evaluate the safety of nuclear power plants. Recent studies pertaining to advanced reactor development have indicated that these new power plants must provide enhanced safety over existing nuclear facilities and be cost-competitive with other energy sources. Risk-informed approaches, beyond traditional PRA, offer the opportunity to optimize design while considering the total life cycle of the plant in order to realize these goals. The use of risk-informed design approaches in the nuclear industry is only beginning, with recent promulgation of risk-informed regulations and proposals for risk-informed codes. This paper briefly summarizes the current state of affairs regarding the use of risk-informed approaches in design. Key points to fully realize the benefit of applying a risk-informed approach to nuclear power plant design are then presented. These points are equally applicable to non-nuclear facilities where optimization for cost competitiveness and/or safety is desired. (author)

EDITORIAL MODERN TECHNOLOGY IN PERIPHERAL HEALTH ...

African Journals Online (AJOL)

hi-tech

2004-06-01

Jun 1, 2004 ... new technology to peripheral health care systems in developing countries. ... and maintenance of medical equipment in Africa, citing information ... operating laboratory equipment, and for emergency lighting for operating ...

Building Information Modeling for Managing Design and Construction

DEFF Research Database (Denmark)

Berard, Ole Bengt

outcome of construction work. Even though contractors regularly encounter design information problems, these issues are accepted as a condition of doing business and better design information has yet to be defined. Building information modeling has the inherent promise of improving the quality of design...... information for work tasks. * Amount of Information – the number of documents and files, and other media, should be appropriate for the scope. The criteria were identified by empirical studies and theory on information quality in the architectural, engineering and construction (AEC) industry and other fields......Contractors planning and executing construction work encounter many kinds of problems with design information, such as uncoordinated drawings and specification, missing relevant information, and late delivery of design information. Research has shown that missing design information and unintended...

Participatory Design & Health Information Technology

DEFF Research Database (Denmark)

Health Information Technology (HIT) continues to increase in importance as a component of healthcare provision, but designing HIT is complex. The creation of cooperative learning processes for future HIT users is not a simple task. The importance of engaging end users such as health professionals......, in collaboration with a wide range of people, a broad repertoire of methods and techniques to apply PD within multiple domains has been established. This book, Participatory Design & Health Information Technology, presents the contributions of researchers from 5 countries, who share their experience and insights......, patients and relatives in the design process is widely acknowledged, and Participatory Design (PD) is the primary discipline for directly involving people in the technological design process. Exploring the application of PD in HIT is crucial to all those involved in engaging end users in HIT design and...

Decoding of grasping information from neural signals recorded using peripheral intrafascicular interfaces.

Science.gov (United States)

Micera, Silvestro; Rossini, Paolo M; Rigosa, Jacopo; Citi, Luca; Carpaneto, Jacopo; Raspopovic, Stanisa; Tombini, Mario; Cipriani, Christian; Assenza, Giovanni; Carrozza, Maria C; Hoffmann, Klaus-Peter; Yoshida, Ken; Navarro, Xavier; Dario, Paolo

2011-09-05

The restoration of complex hand functions by creating a novel bidirectional link between the nervous system and a dexterous hand prosthesis is currently pursued by several research groups. This connection must be fast, intuitive, with a high success rate and quite natural to allow an effective bidirectional flow of information between the user's nervous system and the smart artificial device. This goal can be achieved with several approaches and among them, the use of implantable interfaces connected with the peripheral nervous system, namely intrafascicular electrodes, is considered particularly interesting. Thin-film longitudinal intra-fascicular electrodes were implanted in the median and ulnar nerves of an amputee's stump during a four-week trial. The possibility of decoding motor commands suitable to control a dexterous hand prosthesis was investigated for the first time in this research field by implementing a spike sorting and classification algorithm. The results showed that motor information (e.g., grip types and single finger movements) could be extracted with classification accuracy around 85% (for three classes plus rest) and that the user could improve his ability to govern motor commands over time as shown by the improved discrimination ability of our classification algorithm. These results open up new and promising possibilities for the development of a neuro-controlled hand prosthesis.

Modelling Framework and Assistive Device for Peripheral Intravenous Injections

Science.gov (United States)

Kam, Kin F.; Robinson, Martin P.; Gilbert, Mathew A.; Pelah, Adar

2016-02-01

Intravenous access for blood sampling or drug administration that requires peripheral venepuncture is perhaps the most common invasive procedure practiced in hospitals, clinics and general practice surgeries.We describe an idealised mathematical framework for modelling the dynamics of the peripheral venepuncture process. Basic assumptions of the model are confirmed through motion analysis of needle trajectories during venepuncture, taken from video recordings of a skilled practitioner injecting into a practice kit. The framework is also applied to the design and construction of a proposed device for accurate needle guidance during venepuncture administration, assessed as consistent and repeatable in application and does not lead to over puncture. The study provides insights into the ubiquitous peripheral venepuncture process and may contribute to applications in training and in the design of new devices, including for use in robotic automation.

Planning and design of information systems

CERN Document Server

Blokdijk, André

1991-01-01

Planning and Design of Information Systems provides a theoretical base and a practical method of executing the planning of computerized information systems, and the planning and design of individual applications. The book is organized into five parts, covering the non-technical and nonimplementational part of information systems planning, design, and development. Part I gives the theoretical base for the subsequent parts of the book. It discusses modeling, techniques, notations, boundaries, quality issues and aspects, and decomposition techniques and problems. Part II discusses the needs, prob

Peripheral visual feedback: a powerful means of supporting effective attention allocation in event-driven, data-rich environments.

Science.gov (United States)

Nikolic, M I; Sarter, N B

2001-01-01

Breakdowns in human-automation coordination in data-rich, event-driven domains such as aviation can be explained in part by a mismatch between the high degree of autonomy yet low observability of modern technology. To some extent, the latter is the result of an increasing reliance in feedback design on foveal vision--an approach that fails to support pilots in tracking system-induced changes and events in parallel with performing concurrent flight-related tasks. One possible solution to the problem is the distribution of tasks and information across sensory modalities and processing channels. A simulator study is presented that compared the effectiveness of current foveal feedback and two implementations of peripheral visual feedback for keeping pilots informed about uncommanded changes in the status of an automated cockpit system. Both peripheral visual displays resulted in higher detection rates and faster response times, without interfering with the performance of concurrent visual tasks any more than does currently available automation feedback. Potential applications include improved display designs that support effective attention allocation in a variety of complex dynamic environments, such as aviation, process control, and medicine.

Unipedal stance testing in the assessment of peripheral neuropathy.

Science.gov (United States)

Hurvitz, E A; Richardson, J K; Werner, R A

2001-02-01

To define further the relation between unipedal stance testing and peripheral neuropathy. Prospective cohort. Electroneuromyography laboratory of a Veterans Affairs medical center and a university hospital. Ninety-two patients referred for lower extremity electrodiagnostic studies. A standardized history and physical examination designed to detect peripheral neuropathy, 3 trials of unipedal stance, and electrodiagnostic studies. Peripheral neuropathy was identified by electrodiagnostic testing in 32%. These subjects had a significantly shorter (p unipedal stance time (15.7s, longest of 3 trials) than the patients without peripheral neuropathy (37.1s). Abnormal unipedal stance time (unipedal stance time had a negative predictive value of 90%. Abnormal unipedal stance time was associated with an increased risk of having peripheral neuropathy on univariate analysis (odds ratio = 8.8, 95% confidence interval = 2.5--31), and was the only significant predictor of peripheral neuropathy in the regression model. Aspects of the neurologic examination did not add to the regression model compared with abnormal unipedal stance time. Unipedal stance testing is useful in the clinical setting both to identify and to exclude the presence of peripheral neuropathy.

Information Flows in Networked Engineering Design Projects

DEFF Research Database (Denmark)

Parraguez, Pedro; Maier, Anja

Complex engineering design projects need to manage simultaneously multiple information flows across design activities associated with different areas of the design process. Previous research on this area has mostly focused on either analysing the “required information flows” through activity...... networks at the project level or in studying the social networks that deliver the “actual information flow”. In this paper we propose and empirically test a model and method that integrates both social and activity networks into one compact representation, allowing to compare actual and required...... information flows between design spaces, and to assess the influence that these misalignments could have on the performance of engineering design projects....

The combined influence of central and peripheral routes in the online persuasion process.

Science.gov (United States)

SanJosé-Cabezudo, Rebeca; Gutiérrez-Arranz, Ana M; Gutiérrez-Cillán, Jesús

2009-06-01

The elaboration likelihood model (ELM) is one of the most widely used psychological theories in academic literature to account for how advertising information is processed. The current work seeks to overturn one of the basic principles of the ELM and takes account of new variables in the model that help to explain the online persuasion process more clearly. Specifically, we posit that in a context of high-involvement exposure to advertising (e.g., Web pages), central and peripheral processing routes may act together. In a repeated-measures experimental design, 112 participants were exposed to two Web sites of a fictitious travel agency, differing only in their design--serious versus amusing. Findings evidence that a peripheral cue, such as how the Web pages are presented, does prove relevant when attempting to reflect the level of effectiveness. Moreover, if we take account of individuals' motivation when accessing the Internet, whether cognitive or affective, the motivation will impact their response to the Web site design. The work contributes to ELM literature and may help firms to pinpoint those areas and features of Internet advertising that prove most efficient.

Utilizing Design Information in Aspect-Oriented Programming

OpenAIRE

Nagy, I.; Bergmans, Lodewijk; Havinga, W.K.; Aksit, Mehmet; Hirschfeld, Robert; Kowalczyk, Ryszard; Polze, Andreas; Weske, Mathias

2005-01-01

Traditionally in aspect-oriented languages, pointcut designators select joinpoints of a program based on lexical information such as explicit names of program elements. However, this reduces the adaptability of software, since it involves too much information that is hard-coded, and often implementationspecific. We claim that this problem can be reduced by referring to program units through their design intentions. Design intention is represented by annotated design information, which describ...

Controlling Access to Input/Output Peripheral Devices

Directory of Open Access Journals (Sweden)

E. Y. Rodionov

2010-03-01

Full Text Available In this paper the author proposes a system that manages information security policy on enterprise. Problems related to managing information security policy on enterprise and access to peripheral devices in computer systems functioning under control of Microsoft Windows NT operating systems are considered.

Model-independent spectroscopic information and the peripheral direct capture A(a,γ)B reaction at stellar energies

International Nuclear Information System (INIS)

Igamov, S.B.; Yarmukhamedov, R.

2004-01-01

Full text: Despite the impressive progress in our understanding of these processes has been made in the last decades, there are still many problems connected with obtaining precise data on the A(p,γ )B and A(α,γ )B reactions cross sections at stellar energies to be solved. One of the possibilities of solving these problems is based on the principally peripheral character of charged particles interaction at low energy and the possibility of using the information on asymptotic normalization coefficients (ANC) (or respective nuclear vertex constants (NVC) for the virtual decay B→A+a ) of the overlap functions for the A(p,γ )B and A(α,γ)B reactions. This review is devoted to critical analysis of traditional methods of obtaining ANC information from DWBA - method calculation of proton transfer reactions and two - body potential model calculation of the direct capture reactions. Moreover in this review modified two - body potential approach allowing to determine both the ANC for virtual decays B→p+A and B→α+A and astrophysical S-factor, S(E), for the A(p,γ)B and A(α,γ)B at stellar energies E (∼ 25 keV) is discussed. This method involves two additional conditions that allow to verify the peripheral character of the considered reactions. New information about rates of t( α ,γ ) 7 Li, 3 He(α ,γ ) 7 Be, 7 Be(p,γ ) 8 B and 12 C(p,γ ) 13 N reactions and estimation of the values of the ANC's for 7 Li →α+t, 7 Be→α+ 3 He, and 8 B→ 7 Be+p has also been presented

Peripheral neuropathy in HIV: prevalence and risk factors

Science.gov (United States)

Evans, Scott R.; Ellis, Ronald J.; Chen, Huichao; Yeh, Tzu-min; Lee, Anthony J.; Schifitto, Giovanni; Wu, Kunling; Bosch, Ronald J.; McArthur, Justin C.; Simpson, David M.; Clifford, David B.

2011-01-01

Objectives To estimate neuropathic sign/symptom rates with initiation of combination antiretroviral therapy (cART) in HIV-infected ART-naive patients, and to investigate risk factors for: peripheral neuropathy and symptomatic peripheral neuropathy (SPN), recovery from peripheral neuropathy/SPN after neurotoxic ART (nART) discontinuation, and the absence of peripheral neuropathy/SPN while on nART. Design AIDS Clinical Trials Group (ACTG) Longitudinal Linked Randomized Trial participants who initiated cART in randomized trials for ART-naive patients were annually screened for symptoms/signs of peripheral neuropathy. ART use and disease characteristics were collected longitudinally. Methods Peripheral neuropathy was defined as at least mild loss of vibration sensation in both great toes or absent/hypoactive ankle reflexes bilaterally. SPN was defined as peripheral neuropathy and bilateral symptoms. Generalized estimating equation logistic regression was used to estimate associations. Results Two thousand, one hundred and forty-one participants were followed from January 2000 to June 2007. Rates of peripheral neuropathy/SPN at 3 years were 32.1/8.6% despite 87.1% with HIV-1RNA 400 copies/ml or less and 70.3% with CD4 greater than 350 cells/µl. Associations with higher odds of peripheral neuropathy included older patient age and current nART use. Associations with higher odds of SPN included older patient age, nART use, and history of diabetes mellitus. Associations with lower odds of recovery after nART discontinuation included older patient age. Associations with higher odds of peripheral neuropathy while on nART included older patient age and current protease inhibitor use. Associations with higher odds of SPN while on nART included older patient age, history of diabetes, taller height, and protease inhibitor use. Conclusion Signs of peripheral neuropathy remain despite virologic/immunologic control but frequently occurs without symptoms. Aging is a risk factor for

Information-Processing Models and Curriculum Design

Science.gov (United States)

Calfee, Robert C.

1970-01-01

"This paper consists of three sections--(a) the relation of theoretical analyses of learning to curriculum design, (b) the role of information-processing models in analyses of learning processes, and (c) selected examples of the application of information-processing models to curriculum design problems." (Author)

The relationship between oncologists and peripheral hospital radiologists in the north-west of England

International Nuclear Information System (INIS)

Bungay, Peter M.; Carrington, Bernadette M.; Corgie, Delphine; Eardley, Anne

2002-01-01

AIM: To audit the relationship between Cancer Centre oncologists visiting peripheral hospitals and peripheral hospital radiologists by assessing (i) oncologists' knowledge of local radiological services; (ii) oncologists' perceptions of peripheral radiological services; (iii) peripheral radiologist's perceptions of oncologists; (iv) barriers to communication. MATERIALS AND METHODS: A postal questionnaire was sent to all radiology departments visited by an oncologist, and to all medical and clinical oncologists from two regional oncology centres. RESULTS: The response rate was 100% (21 peripheral hospital radiology departments and all 35 oncologists). (i) Oncologists' knowledge of peripheral hospital imaging modalities was limited (especially MRI and intervention). (ii) 72% of oncologists rated the peripheral hospital radiology service as excellent or good, 46% rated the radiology report quality excellent to good. Deficiencies in oncological reports were identified. (iii) 44% of radiologists thought the oncologist did not relate well with the local radiology department. 50% of radiologists did not know the visiting oncologist's specialist interest. (iv) 69% of oncologists did not regularly attend peripheral hospital clinico-radiological meetings. Lack of written and oral information was hampering both specialities. CONCLUSION: Communication between oncologists and the local radiology department should include: (1) information about local radiology services for visiting oncologists (including trainees) and on the oncology team for radiologists; (2) standardized report content; (3) improved clinical information for radiologists; (4) regular clinico-radiological meetings. Bungay, P.M. et al. (2002)

Trends in the design of nerve guidance channels in peripheral nerve tissue engineering.

Science.gov (United States)

Chiono, Valeria; Tonda-Turo, Chiara

2015-08-01

The current trend of peripheral nerve tissue engineering is the design of advanced nerve guidance channels (NGCs) acting as physical guidance for regeneration of nerves across lesions. NGCs should present multifunctional properties aiming to direct the sprouting of axons from the proximal nerve end, to concentrate growth factors secreted by the injured nerve ends, and to reduce the ingrowth of scar tissue into the injury site. A critical aspect in the design of NGCs is conferring them the ability to provide topographic, chemotactic and haptotactic cues that lead to functional nerve regeneration thus increasing the axon growth rate and avoiding or minimizing end-organ (e.g. muscle) atrophy. The present work reviews the recent state of the art in NGCs engineering and defines the external guide and internal fillers structural and compositional requirements that should be satisfied to improve nerve regeneration, especially in the case of large gaps (>2 cm). Techniques for NGCs fabrication were described highlighting the innovative approaches direct to enhance the regeneration of axon stumps compared to current clinical treatments. Furthermore, the possibility to apply stem cells as internal cues to the NGCs was discussed focusing on scaffold properties necessary to ensure cell survival. Finally, the optimized features for NGCs design were summarized showing as multifunctional cues are needed to produce NGCs having improved results in clinics. Copyright © 2015 Elsevier Ltd. All rights reserved.

Decoding of grasping information from neural signals recorded using peripheral intrafascicular interfaces

Directory of Open Access Journals (Sweden)

Cipriani Christian

2011-09-01

Full Text Available Abstract Background The restoration of complex hand functions by creating a novel bidirectional link between the nervous system and a dexterous hand prosthesis is currently pursued by several research groups. This connection must be fast, intuitive, with a high success rate and quite natural to allow an effective bidirectional flow of information between the user's nervous system and the smart artificial device. This goal can be achieved with several approaches and among them, the use of implantable interfaces connected with the peripheral nervous system, namely intrafascicular electrodes, is considered particularly interesting. Methods Thin-film longitudinal intra-fascicular electrodes were implanted in the median and ulnar nerves of an amputee's stump during a four-week trial. The possibility of decoding motor commands suitable to control a dexterous hand prosthesis was investigated for the first time in this research field by implementing a spike sorting and classification algorithm. Results The results showed that motor information (e.g., grip types and single finger movements could be extracted with classification accuracy around 85% (for three classes plus rest and that the user could improve his ability to govern motor commands over time as shown by the improved discrimination ability of our classification algorithm. Conclusions These results open up new and promising possibilities for the development of a neuro-controlled hand prosthesis.

Online shopping interface components: relative importance as peripheral and central cues.

Science.gov (United States)

Warden, Clyde A; Wu, Wann-Yih; Tsai, Dungchun

2006-06-01

The Elaboration Likelihood Model (ELM) uses central (more thoughtful) and peripheral (less thoughtful) routes of persuasion to maximize communication effectiveness. This research implements ELM to investigate the relative importance of different aspects of the user experience in online shopping. Of all the issues surrounding online shopping, convenience, access to information, and trust were found to be the most important. These were implemented in an online conjoint shopping task. Respondents were found to use the central route of the ELM on marketing messages that involved issues of minimizing travel, information access, and assurances of system security. Users employed the peripheral ELM route when considering usability, price comparison, and personal information protection. A descriptive model of Web-based marketing components, their roles in the central and peripheral routes, and their relative importance to online consumer segments was developed.

Supporting work practices through telehealth: impact on nurses in peripheral regions

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Courcy François

2011-02-01

Full Text Available Abstract Background In Canada, workforce shortages in the health care sector constrain the ability of the health care system to meet the needs of its population and of its health care professionals. This issue is of particular importance in peripheral regions of Quebec, where significant inequalities in workforce distribution between regions has lead to acute nursing shortages and increased workloads. Information and communication technologies (ICTs are innovative solutions that can be used to develop strategies to optimise the use of available resources and to design new nursing work practices. However, current knowledge is still limited about the real impact of ICTs on nursing recruitment and retention. Our aim is to better understand how work practice reorganization, supported by ICTs, and particularly by telehealth, may influence professional, educational, and organizational factors relating to Quebec nurses, notably those working in peripheral regions. Methods/Design First, we will conduct a descriptive study on the issue of nursing recruitment. Stratified sampling will be used to select approximately twenty innovative projects relating to the reorganization of work practices based upon ICTs. Semi-structured interviews with key informants will determine professional, educational, and organizational recruitment factors. The results will be used to create a questionnaire which, using a convenience sampling method, will be mailed to 600 third year students and recent graduates of two Quebec university nursing faculties. Descriptive, correlation, and hierarchical regression analyses will be performed to identify factors influencing nursing graduates' intentions to practice in peripheral regions. Secondly, we will conduct five case studies pertaining to the issue of nursing retention. Five ICT projects in semi-urban, rural, and isolated regions have been identified. Qualitative data will be collected through field observation and approximately

Information processing theory in the early design stages

DEFF Research Database (Denmark)

Cash, Philip; Kreye, Melanie

2014-01-01

suggestions for improvements and support. One theory that may be particularly applicable to the early design stages is Information Processing Theory (IPT) as it is linked to the design process with regard to the key concepts considered. IPT states that designers search for information if they perceive......, the new knowledge is shared between the design team to reduce ambiguity with regards to its meaning and to build a shared understanding – reducing perceived uncertainty. Thus, we propose that Information-Processing Theory is suitable to describe designer activity in the early design stages...... uncertainty with regard to the knowledge necessary to solve a design challenge. They then process this information and compare if the new knowledge they have gained covers the previous knowledge gap. In engineering design, uncertainty plays a key role, particularly in the early design stages which has been...

Designing informal learning spaces using student perspectives

Directory of Open Access Journals (Sweden)

Matthew David Riddle

2012-06-01

Full Text Available This article describes the design of informal learning spaces at an Australian university that support students in the generation of knowledge. Recent learning space design projects at La Trobe have been informed by a number of pre-existing projects, including a small research project on student use of technologies, a national project on learning space design, and a significant curriculum renewal process at the university. It demonstrates the ways in which evidence based on student perspectives and principles developed through applied research in teaching and learning can inform real world learning space design projects in a higher education context.

Human Information Behaviour and Design, Development and Evaluation of Information Retrieval Systems

Science.gov (United States)

Keshavarz, Hamid

2008-01-01

Purpose: The purpose of this paper is to introduce the concept of human information behaviour and to explore the relationship between information behaviour of users and the existing approaches dominating design and evaluation of information retrieval (IR) systems and also to describe briefly new design and evaluation methods in which extensive…

Lipid-lowering drugs (statins) and peripheral neuropathy.

Science.gov (United States)

Emad, Mohammadreza; Arjmand, Hosein; Farpour, Hamid Reza; Kardeh, Bahareh

2018-03-01

Peripheral neuropathy is a disorder with often unknown causes. Some drugs, including statins, are proposed to be among the causes of peripheral neuropathy. This study aimed at evaluating this condition by electrodiagnostic study among patients who had received statins. This case-control study was conducted in Shiraz, Iran in 2015, and included 39 patients aged 35-55 who had received statins for at least 6 months, and 39 healthy matched controls. Using electrodiagnosis, the sensory and motor wave features (amplitude, latency and nerve conduction velocity) of the peripheral nerves (Median, Ulnar, Tibial, Sural, and Peroneal) were evaluated among the subjects. Data were analyzed using SPSS software and pneuropathy, there were no significant differences in any of the definitions presented for peripheral neuropathy. However, the difference was close to significance for one definition [2 abnormalities in 2 nerves (p=0.055)]. Regarding mean values of the features, significant differences were observed in two features: amplitude of the peroneal motor nerve (p=0.048) and amplitude of the sural sensory nerve (p=0.036). Since statins are widely used, awareness regarding their side-effects would lead to better treatment. Even though no significant differences were found between the groups regarding the occurrence of peripheral neuropathy, there were significant differences in amplitudes of the sural sensory response and the peroneal motor response. This indicates the involvement of peripheral nerves. Therefore, we recommend that patients and physicians should be informed about the possible symptoms of this condition.

Research on Design Information Management System for Leather Goods

Science.gov (United States)

Lu, Lei; Peng, Wen-li

The idea of setting up a design information management system of leather goods was put forward to solve the problems existed in current information management of leather goods. Working principles of the design information management system for leather goods were analyzed in detail. Firstly, the acquiring approach of design information of leather goods was introduced. Secondly, the processing methods of design information were introduced. Thirdly, the management of design information in database was studied. Finally, the application of the system was discussed by taking the shoes products as an example.

PLGA nanofibers blended with designer self-assembling peptides for peripheral neural regeneration

Energy Technology Data Exchange (ETDEWEB)

Nune, Manasa; Krishnan, Uma Maheswari; Sethuraman, Swaminathan, E-mail: swami@sastra.edu

2016-05-01

Electrospun nanofibers are attractive candidates for neural regeneration due to similarity to the extracellular matrix. Several synthetic polymers have been used but they lack in providing the essential biorecognition motifs on their surfaces. Self-assembling peptide nanofiber scaffolds (SAPNFs) like RADA16 and recently, designer SAPs with functional motifs RADA16-I-BMHP1 areexamples, which showed successful spinal cord regeneration. But these peptide nanofiber scaffolds have poor mechanical properties and faster degradation rates that limit their use for larger nerve defects. Hence, we have developed a novel hybrid nanofiber scaffold of polymer poly(L-lactide-co-glycolide) (PLGA) and RADA16-I-BMHP1. The scaffolds were characterized for the presence of peptides both qualitatively and quantitatively using several techniques like SEM, EDX, FTIR, CHN analysis, Circular Dichroism analysis, Confocal and thermal analysis. Peptide self-assembly was retained post-electrospinning and formed rod-like nanostructures on PLGA nanofibers. In vitro cell compatibility was studied using rat Schwann cells and their adhesion, proliferation and gene expression levels on the designed scaffolds were evaluated. Our results have revealed the significant effects of the peptide blended scaffolds on promoting Schwann cell adhesion, extension and phenotypic expression. Neural development markers (SEM3F, NRP2 & PLX1) gene expression levels were significantly upregulated in peptide blended scaffolds compared to the PLGA scaffolds. Thus the hybrid blended novel designer scaffolds seem to be promising candidates for successful and functional regeneration of the peripheral nerve. - Highlights: • A novel blended scaffold of polymer PLGA and designer self-assembling peptide RADA16-I-BMPH1 was designed • The peptide retained the self-assembling features and formed rod like nanostructures on top of PLGA nanofibers • PLGA-peptide scaffolds have promoted the Schwann cell bipolar extension and

Designing Data Visualizations Representing Informational Relationships

CERN Document Server

Steele, Julie

2011-01-01

Data visualization is an efficient and effective medium for communicating large amounts of information, but the design process can often seem like an unexplainable creative endeavor. This concise book aims to demystify the design process by showing you how to use a linear decision-making process to encode your information visually. Delve into different kinds of visualization, including infographics and visual art, and explore the influences at work in each one. Then learn how to apply these concepts to your design process. Learn data visualization classifications, including explanatory, expl

Prospective surveillance of phlebitis associated with peripheral intravenous catheters.

Science.gov (United States)

Malach, Tal; Jerassy, Ziona; Rudensky, Bernard; Schlesinger, Yechiel; Broide, Etty; Olsha, Oded; Yinnon, Amos M; Raveh, David

2006-06-01

Guidelines have been published for prevention of phlebitis associated with peripheral intravenous catheters (IVC), but this complication continues to occur. We sought to determine the rate of phlebitis associated with peripheral IVCs to identify predictors for phlebitis and to isolate pathogenic bacteria from phlebitic catheter tips. Nine-point prevalence studies were conducted during the years 1996-2003 of all hospitalized patients with a peripheral IVC. During the last 3 surveys, conducted in 2003, phlebitic lines were removed, and, for each line, 1 to 2 nonphlebitic lines, in place for 48 to 72 hours, were removed and cultured as controls. In between these surveys, findings and guidelines for improvement were distributed to the staff. During these surveys, 40% +/- 8% of hospitalized patients had a peripheral IVC. The rate of peripheral IVC-associated phlebitis decreased from 12.7% (20/157) in 1998 to 2.6% (5/189) in 2003 (P phlebitis included pain (P phlebitis associated with peripheral intravenous catheters decreased significantly throughout the study period. The identification of predictors for phlebitis and the dissemination of this information in an educational drive may have contributed to this improvement.

Peripheral Protein Unfolding Drives Membrane Bending.

Science.gov (United States)

Siaw, Hew Ming Helen; Raghunath, Gokul; Dyer, R Brian

2018-06-20

Dynamic modulation of lipid membrane curvature can be achieved by a number of peripheral protein binding mechanisms such as hy-drophobic insertion of amphipathic helices and membrane scaffolding. Recently, an alternative mechanism was proposed in which crowding of peripherally bound proteins induces membrane curvature through steric pressure generated by lateral collisions. This effect was enhanced using intrinsically disordered proteins that possess high hydrodynamic radii, prompting us to explore whether membrane bending can be triggered by the folding-unfolding transition of surface-bound proteins. We utilized histidine-tagged human serum albumin bound to Ni-NTA-DGS containing liposomes as our model system to test this hypothesis. We found that reduction of the disulfide bonds in the protein resulted in unfolding of HSA, which subsequently led to membrane tubule formation. The frequency of tubule formation was found to be significantly higher when the proteins were unfolded while being localized to a phase-separated domain as opposed to randomly distributed in fluid phase liposomes, indicating that the steric pressure generated from protein unfolding is directly responsible for membrane deformation. Our results are critical for the design of peripheral membrane protein-immobilization strategies and open new avenues for exploring mechanisms of membrane bending driven by conformational changes of peripheral membrane proteins.

Motivational Design in Information Literacy Instruction

Science.gov (United States)

Hess, Amanda Nichols

2015-01-01

Motivational design theory complements instructional design theory and, when used together, both principles can affect learning, knowledge acquisition, and knowledge retention. In information literacy instruction, motivational design exists throughout the appropriate standards documents. However, there is limited current research on the best…

Design of Object-based Information System Prototype

OpenAIRE

Suhyeon Yoo; Sumi Shin; Hyesun Kim

2014-01-01

Researchers who use science and technology information were found to ask an information service in which they can excerpt the contents they needed, rather than using the information at article level. In this study, we micronized the contents of scholarly articles into text, image, and table and then constructed a micro-content DB to design a new information system prototype based on this micro-content. After designing the prototype, we performed usability test for this prototype so as to conf...

Vasculitic peripheral neuropathy

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Mona Amini

2014-02-01

Full Text Available Primary systemic vasculitis in pre-capillary arteries is associated with peripheral neuropathy. In some types of systematic vasculitis about 60 % of patients have peripheral nervous system (PNS involvement. In vasculitic peripheral neuropathies (VPN a necrotizing and inflammatory process leads to narrowing of vasa nervorum lumen and eventually the appearance of ischemic lesions in peripheral nerves. Some features might be suggestive of VPN, like: axonal nerve degeneration, wallerian-like degeneration, and diameter irregularity of nerve. Peripheral nervous system (PNS destruction during systemic vasculitides should be considered, due to its frequency and early occurrence in vasculitis progression. The first line treatment of non systematic VPNs is corticosteroid agents, but these drugs might worsen the VPNs or systemic vasculitis.

Effect of peripheral morphine in a human model of acute inflammatory pain

DEFF Research Database (Denmark)

Lillesø, J; Hammer, N A; Pedersen, J L

2000-01-01

Several studies have demonstrated the presence of opioid inducible receptors on peripheral nerves and peripheral antinociceptive effects of opioids. However, the effects of peripheral opioid administration in man are controversial. Our study used a randomized, double-blind, placebo-controlled, th......Several studies have demonstrated the presence of opioid inducible receptors on peripheral nerves and peripheral antinociceptive effects of opioids. However, the effects of peripheral opioid administration in man are controversial. Our study used a randomized, double-blind, placebo......-controlled, three-way crossover design in a human model of acute inflammatory pain (heat injury). We studied 18 healthy volunteers who each received morphine locally (2 mg), morphine systemically (2 mg), or placebo on three separate study days. The subjects received morphine infiltration subcutaneously (s.c.). 1 h......, but local morphine infiltration neither reduced pain during the burn, nor primary or secondary hyperalgesia to mechanical and heat stimuli after the burn. In conclusion, peripherally applied morphine had no acute antinociceptive effects in this human model of acute inflammatory pain....

Implementing risk-informed life-cycle design

International Nuclear Information System (INIS)

Hill, Ralph S.

2009-01-01

This paper describes a design process based on risk-informed probabilistic design methodologies that cover a facility's life-cycle from start of conceptual design through decontamination and decommissioning. The concept embodies use of probabilistic risk assessments to establish target reliabilities for facility systems and components. The target reliabilities are used for system based code margin exchange and performance simulation analyses to optimize design over all phases (design, construction, operation and decommissioning) of a facility's life-cycle. System based code margin exchange reduces excessive level of construction margins for passive components to appropriate levels resulting in a more flexible structure of codes and standards that improves facility reliability and cost. System and subsystem simulation analyses determine the optimum combination of initial system and component construction reliability, maintenance frequency, and inspection frequency for both active and passive components. The paper includes a description of these risk-informed life-cycle design processes, a summary of work being done, and a discussion of additional work needed to implement the process.

Information Management for Factory Planning and Design

OpenAIRE

Chen, Danfang

2012-01-01

This thesis is dedicated to the manufacturing industry for the improvement of information management within the factory planningand design domain, and for more efficient factory planning and design. Currently the manufacturing industry lacks sufficient methods for capturing, structuring, and representing information and knowledge for easy access, exchange, integration and reuse within the domain. Therefore the focus of this thesis is on information and knowledge management within factory plan...

Case study of physiotherapeutic treatment of patient with diagnosis facial nerve peripheral palsy

OpenAIRE

Zahrádková, Tereza

2015-01-01

Title of Bachelorʼs thesis: Case study of physiotherapeutic treatment of patient with diagnosis facial nerve peripheral palsy. Aim of thesis: Summary of theoretical findings of patientʼs diagnosis, study metodology of physiotherapeutic care, treatment design, monitoring of treatment, and evaluate the effect of patient with diagnosis facial nerve peripheral palsy. Summary: This thesis comprehensively summarizes the findings of of peripheral facial nerve palsy and it's treatment with physiotera...

INFORMED DESIGN DECISION-MAKING: FROM DIGITAL ANALYSIS TO URBAN DESIGN

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Camilla Pezzica

2017-11-01

Full Text Available This study describes a new approach to explore the design of public open spaces based on a multidimensional analysis useful to inform decision-making and foster the development of evidence-based architectural solutions. It presents an overview of the most relevant design variables and their constraints, providing, in this way, valuable information for the elaboration of a more sustainable urban design, considerate of the local socio-cultural values. This research aims at providing holistic guidance for the development of better design proposals in contemporary urban environments. More specifically, it seeks to synchronously characterize urban spaces at a multi-scale and multidimensional level, both quantitatively and qualitatively, by collecting contributions from Space Syntax Theory, Public Life Studies, Building Science and Environmental/Comfort Analysis in public open spaces. Many advanced digital tools are used for data management purposes and to generate and test iteratively different design proposals. The proposed methodology is based on a range of tests and analyses performed in the process of developing a new experimental project for Largo da Graça, an urban square located in Lisbon’s historic centre, which allowed the testing of different design solutions. This experiment generated a digital workflow for the design of the urban square, in which are registered all the steps undertaken to solve the many design problems identified by considering the efficiency targets (centrality, connectivity, enclosure, thermal comfort, security, social equity and interaction. The process comprises a sequence of comparative design reviews and records the choices made when dealing with latent information underlying changing conditions in the use of public space and the programmatic malleability of the Portuguese plaza. The description of the adopted design strategy and the examples extracted from the workflow are used to illustrate the practical

Geo-communication and information design

DEFF Research Database (Denmark)

Brodersen, Lars

2009-01-01

of processes, procedures, factors, relations etc., all forming parts of a theory on geo-communication and information design. How do we decide whether to transmit content A or content B to another person? We make a decision. Making decisions does not normally give rise to difficulties, although a great deal......This article is an abstract of the book 'Geo-communication and information design'. The work involved in the book was inspired by the author's sense of wonder that there were apparently no existing theories, models etc. capable of identifying and choosing the content of information in systematic...... of debate might occur during the decision-making process. But if the question is extended to include a demand for systematics and consciousness (control) in the procedure adopted, the whole issue becomes more complex. How do we decide to transmit content A or content B to another person on a systematic...

Peripheral biomarkers revisited: integrative profiling of peripheral samples for psychiatric research.

Science.gov (United States)

Hayashi-Takagi, Akiko; Vawter, Marquis P; Iwamoto, Kazuya

2014-06-15

Peripheral samples, such as blood and skin, have been used for decades in psychiatric research as surrogates for central nervous system samples. Although the validity of the data obtained from peripheral samples has been questioned and other state-of-the-art techniques, such as human brain imaging, genomics, and induced pluripotent stem cells, seem to reduce the value of peripheral cells, accumulating evidence has suggested that revisiting peripheral samples is worthwhile. Here, we re-evaluate the utility of peripheral samples and argue that establishing an understanding of the common signaling and biological processes in the brain and peripheral samples is required for the validity of such models. First, we present an overview of the available types of peripheral cells and describe their advantages and disadvantages. We then briefly summarize the main achievements of omics studies, including epigenome, transcriptome, proteome, and metabolome analyses, as well as the main findings of functional cellular assays, the results of which imply that alterations in neurotransmission, metabolism, the cell cycle, and the immune system may be partially responsible for the pathophysiology of major psychiatric disorders such as schizophrenia. Finally, we discuss the future utility of peripheral samples for the development of biomarkers and tailor-made therapies, such as multimodal assays that are used as a battery of disease and trait pathways and that might be potent and complimentary tools for use in psychiatric research. © 2013 Society of Biological Psychiatry Published by Society of Biological Psychiatry All rights reserved.

Designing informal learning spaces using student perspectives

OpenAIRE

Matthew David Riddle; Kay Souter

2012-01-01

This article describes the design of informal learning spaces at an Australian university that support students in the generation of knowledge. Recent learning space design projects at La Trobe have been informed by a number of pre-existing projects, including a small research project on student use of technologies, a national project on learning space design, and a significant curriculum renewal process at the university. It demonstrates the ways in which evidence based on student perspectiv...

Ultrasonic stimulation of peripheral nervous tissue: an investigation into mechanisms

International Nuclear Information System (INIS)

Wright, C J; Saffari, N; Rothwell, J

2015-01-01

Neuro-stimulation has wide ranging clinical and research potential but this is currently limited either by low resolution, penetration or by highly invasive procedures. It has been reported in previous studies that ultrasound is able to elicit a neuro-stimulatory effect at a higher resolution than other non-invasive approaches but both the underlying mechanism that makes this possible and the practical details of how it can be implemented are still poorly understood. The current study has identified the main issues that need to be resolved in the field, proposing several different approaches to tackling these areas. An isolated in vitro peripheral nerve bundle was chosen as a simple model to demonstrate and investigate the neuro-stimulatory effect after preliminary results showed successful stimulation in a skin-nerve preparation. Early results from the nerve bundle show successful neurostimulation, indicating that structures in the peripheral nerve axon are sensitive to ultrasound. Further research using this model should reveal more precisely what structures are being affected and how to optimise the effect, helping to inform the design of future procedures and devices used in in vivo applications

Peripheral reactions

International Nuclear Information System (INIS)

Greiner, D.

1978-01-01

Peripheral collisions, that is, collisions involving a small amount of overlap of nuclear matter, are discussed including inclusive interactions, the magnitude of the peripheral cross section, fragmentation, a compilation of experiments and available data, limiting fragmentation, factorization, some models, fragment momentum distributions, and future research directions

The earthquake problem in engineering design: generating earthquake design basis information

International Nuclear Information System (INIS)

Sharma, R.D.

1987-01-01

Designing earthquake resistant structures requires certain design inputs specific to the seismotectonic status of the region, in which a critical facility is to be located. Generating these inputs requires collection of earthquake related information using present day techniques in seismology and geology, and processing the collected information to integrate it to arrive at a consolidated picture of the seismotectonics of the region. The earthquake problem in engineering design has been outlined in the context of a seismic design of nuclear power plants vis a vis current state of the art techniques. The extent to which the accepted procedures of assessing seismic risk in the region and generating the design inputs have been adherred to determine to a great extent the safety of the structures against future earthquakes. The document is a step towards developing an aproach for generating these inputs, which form the earthquake design basis. (author)

Catheter indwell time and phlebitis development during peripheral intravenous catheter administration.

Science.gov (United States)

Pasalioglu, Kadriye Burcu; Kaya, Hatice

2014-07-01

Intravenous catheters have been indispensable tools of modern medicine. Although intravenous applications can be used for a multitude of purposes, these applications may cause complications, some of which have serious effects. Of these complications, the most commonly observed is phlebitis. This study was conducted to determine the effect of catheter indwell time on phlebitis development during peripheral intravenous catheter administration. This study determined the effect of catheter indwell time on phlebitis development during peripheral intravenous catheter administration. The study included a total of 103 individuals who were administered 439 catheters and satisfied the study enrollment criteria at one infectious diseases clinic in Istanbul/Turkey. Data were compiled from Patient Information Forms, Peripheral Intravenous Catheter and Therapy Information Forms, reported grades based on the Visual Infusion Phlebitis Assessment Scale, and Peripheral Intravenous Catheter Nurse Observation Forms. The data were analyzed using SPSS. Results : The mean patient age was 53.75±15.54 (standard deviation) years, and 59.2% of the study participants were men. Phlebitis was detected in 41.2% of peripheral intravenous catheters, and the rate decreased with increased catheter indwell time. Analyses showed that catheter indwell time, antibiotic usage, sex, and catheterization sites were significantly associated with development of phlebitis. The results of this study show that catheters can be used for longer periods of time when administered under optimal conditions and with appropriate surveillance.

Long-Term Visual Prognosis of Peripheral Multifocal Chorioretinitis

NARCIS (Netherlands)

Ossewaarde-van Norel, J; ten Dam-van Loon, NH; de Boer, JH; Rothova, A.

2015-01-01

Purpose To report on the clinical manifestations, complications, and long-term visual prognosis of patients with peripheral multifocal chorioretinitis and to search for predictors for a lower visual outcome. Design Retrospective consecutive observational case series. Methods setting: Institutional.

Peripheral Developing Odontoma or Peripheral Ameloblastic Fibroodontoma: A Rare Challenging Case

Directory of Open Access Journals (Sweden)

Saede Atarbashi Moghadam

2016-01-01

Full Text Available Peripheral odontogenic lesions are considered to be rare within the classification of odontogenic tumors. They share the same microscopic characteristics of their central counterparts. Here, we report an ulcerated mass of the maxillary gingiva that on histopathological examination was diagnosed as peripheral developing odontoma or peripheral ameloblastic fibroodontoma. The diagnosis of this tumor is challenging and may lead to unnecessary treatment.

Peripheral Neuropathy and Agent Orange

Science.gov (United States)

... Enter ZIP code here Enter ZIP code here Peripheral Neuropathy and Agent Orange VA presumes Veterans' early-onset ... 10 percent disabling by VA's rating regulations. About peripheral neuropathy Peripheral neuropathy is a condition of the peripheral ...

The comparison of CT findings between peripheral pulmonary squamous cell carcinoma and pulmonary adenocarcinoma

International Nuclear Information System (INIS)

Tan Guosheng; Yang Xufeng; Zhou Xuhui; Li Ziping; Fan Miao; Chen Jindi

2007-01-01

Objective: To compare the principal HRCT features of peripheral pulmonary squamous cell carcinoma and pulmonary adenocarcinoma and to explore their pathological mechanism, in order to improve the recognition of the CT signs of peripheral pulmonary carcinoma. Methods: The principal HRCT signs of thirty-five cases with pathologically proved peripheral pulmonary squamous cell carcinoma and forty cases with pathologically proved peripheral pulmonary adenocarcinoma were analyzed retrospectively to explore the relationship between CT features and pathological findings. Results: The main features of peripheral pulmonary squamous cell carcinoma included larger masses, clear boundary, superficial sublobes and intra-tumor necrosis. While peripheral pulmonary adenocarcinoma mostly demonstrated as smaller nodules, deep sublobes, spiculations, spiculate protuberance, pleural indentation, vessel converging signs, and vacuole signs. The different of these above findings of peripheral pulmonary squamous cell carcinoma and adenocarcinoma were significant (P<0.05). Peripheral pulmonary squamous cell carcinoma may depict bronchial casts and polygonal nodules; and peripheral pulmonary adenocarcinoma may demonstrate ground glass-like nodules. Conclusion: The difference of the CT findings between peripheral pulmonary squamous cell carcinoma and peripheral adenocarcinoma is based on their different histological features and biological behaviors. It is possible to differentiate them before operation in combination with clinical information. (authors)

The Information Infrastructures Design Space

DEFF Research Database (Denmark)

Henningsson, Stefan; Rapti, Charikleia; Jensen, Thomas

2017-01-01

This paper develops a framework for characterising the design space of Information Infrastructures (IIs). Existing research has generally sought to unravel the convergent characteristics and mechanisms uniting IIs across a wide range of manifestations. In this research, we explore this divergence...... within the II design space. We do so by reviewing the II literature, focusing on the two domains of design situation and design resolution. Design situation refers to the relevant dimensions of the context in which an II is employed. Design resolution covers the dimensions along which the socio......-technical constituents can be assembled to form an effective solution. The resulting framework allows for the comparing and contrasting of II initiatives, and contributes towards a cumulative knowledge process aimed at a more refined understanding of how an II can be configured to address the specific problem at hand....

Vascular access in neonatology: peripherally inserted central catheter and peripheral venous catheter

Directory of Open Access Journals (Sweden)

Marcia Lienemann

2014-04-01

The objective of this paper is to present aspects of peripherally inserted central catheter and peripheral venous catheter, highlighting important points in choosing the type of access. For the passage of peripherally inserted central catheter is previously performing specific course necessary, while the primary indication occurs when it is necessary to access the patient's stay for a long period of time. Whereas peripheral venipuncture is the most appropriate in cases of needing an IV line quickly and safely, for the administration of fluids, blood collection, blood transfusion and other.

Are peripheral opioid antagonists the solution to opioid side effects?

LENUS (Irish Health Repository)

Bates, John J

2012-02-03

Opioid medication is the mainstay of therapy for severe acute and chronic pain. Unfortunately, the side effects of these medications can affect patient comfort and safety, thus limiting their proven therapeutic potential. Whereas the main analgesic effects of opioids are centrally mediated, many of the common side effects are mediated via peripheral receptors. Novel peripheral opioid antagonists have been recently introduced that can block the peripheral actions of opioids without affecting centrally mediated analgesia. We review the clinical and experimental evidence of their efficacy in ameliorating opioid side effects and consider what further information might be useful in defining their role. IMPLICATIONS: The major analgesic effects of opioid medication are mediated within the brain and spinal cord. Many of the side effects of opioids are caused by activation of receptors outside these areas. Recently developed peripherally restricted opioid antagonists have the ability to block many opioid side effects without affecting analgesia.

Simple Radiowave-Based Method For Measuring Peripheral Blood Flow Project

Science.gov (United States)

Oliva-Buisson, Yvette J.

2014-01-01

Project objective is to design small radio frequency based flow probes for the measurement of blood flow velocity in peripheral arteries such as the femoral artery and middle cerebral artery. The result will be the technological capability to measure peripheral blood flow rates and flow changes during various environmental stressors such as microgravity without contact to the individual being monitored. This technology may also lead to an easier method of detecting venous gas emboli during extravehicular activities.

Peripheral Arterial Disease Study (PERART: Prevalence and predictive values of asymptomatic peripheral arterial occlusive disease related to cardiovascular morbidity and mortality

Directory of Open Access Journals (Sweden)

Bundó Magda

2007-12-01

Full Text Available Abstract Background The early diagnosis of atherosclerotic disease is essential for developing preventive strategies in populations at high risk and acting when the disease is still asymptomatic. A low ankle-arm index (AAI is a good marker of vascular events and may be diminished without presenting symptomatology (silent peripheral arterial disease. The aim of the PERART study (PERipheral ARTerial disease is to determine the prevalence of peripheral arterial disease (both silent and symptomatic in a general population of both sexes and determine its predictive value related to morbimortality (cohort study. Methods/Design This cross-over, cohort study consists of 2 phases: firstly a descriptive, transversal cross-over study to determine the prevalence of peripheral arterial disease, and secondly, a cohort study to evaluate the predictive value of AAI in relation to cardiovascular morbimortality. From September 2006 to June 2007, a total of 3,010 patients over the age of 50 years will be randomly selected from a population adscribed to 24 healthcare centres in the province of Barcelona (Spain. The diagnostic criteria of peripheral arterial disease will be considered as an AAI Discussion In this study we hope to determine the prevalence of peripheral arterial disease, especially the silent forms, in the general population and establish its relationship with cardiovascular morbimortality. A low AAI may be a better marker of arterial disease than the classical cardiovascular risk factors and may, therefore, contribute to improving the predictive value of the equations of cardiovascular risk and thereby allowing optimisation of multifactorial treatment of atherosclerotic disease.

Case report of physiotherapy care for a patient with facial nervus peripheral palsy

OpenAIRE

Kubartová, Veronika

2016-01-01

The title of the thesis: Case report of physiotherapy care for a patient with facial nervus peripheral palsy The aim of the thesis: The aim is to get acquainted with theoretical knowledge on the issues and the development of case studies, including design and the course of therapy for a patient with a diagnosis of facial nervus peripheral palsy. Methodology and evaluation: The content of this thesis is to introduce theoretical knowledge of facial nervus peripheral palsy, its treatment and reh...

Ultrasound Guidance as a Rescue Technique for Peripheral Intravenous Cannulation

National Research Council Canada - National Science Library

Pappas, Nancy L; Michaud, Terese E; Wolbers, Russell M; Steward, James C; Fevurly, Thomas A; Samolitis, Timothy J; Shoneboom, Bruce A; Watts, Dorraine D

2006-01-01

.... Ultrasound guidance has shown efficacy in expediting the cannulation of central veins, but there is limited information on its utility in facilitating cannulation in peripheral veins, particularly...

High School Student Information Access and Engineering Design Performance

Science.gov (United States)

Mentzer, Nathan

2014-01-01

Developing solutions to engineering design problems requires access to information. Research has shown that appropriately accessing and using information in the design process improves solution quality. This quasi-experimental study provides two groups of high school students with a design problem in a three hour design experience. One group has…

Carvedilol prevents functional deficits in peripheral nerve mitochondria of rats with oxaliplatin-evoked painful peripheral neuropathy

International Nuclear Information System (INIS)

Areti, Aparna; Komirishetty, Prashanth; Kumar, Ashutosh

2017-01-01

Oxaliplatin use as chemotherapeutic agent is frequently limited by cumulative neurotoxicity which may compromise quality of life. Reports relate this neurotoxic effect to oxidative stress and mitochondrial dysfunction in peripheral nerves and dorsal root ganglion (DRG). Carvedilol is an antihypertensive drug, has also been appreciated for its antioxidant and mitoprotective properties. Carvedilol co-treatment did not reduce the anti-tumor effects of oxaliplatin in human colon cancer cells (HT-29), but exhibited free radical scavenging activity against oxaliplatin-induced oxidative stress in neuronal cells (Neuro-2a). Hence, the present study was designed to investigate the effect of carvedilol in the experimental model of oxaliplatin-induced peripheral neuropathy (OIPN) in Sprague-Dawley rats. Oxaliplatin reduced the sensory nerve conduction velocity and produced the thermal and mechanical nociception. Carvedilol significantly (P < 0.001) attenuated these functional and sensorimotor deficits. It also counteracted oxidative/nitrosative stress by reducing the levels of nitrotyrosine and improving the mitochondrial superoxide dismutase expression in both sciatic nerve and DRG tissues. It improved the mitochondrial function and prevented the oxaliplatin-induced alteration in mitochondrial membrane potential in sciatic nerve thus prevented loss of intra epidermal nerve fiber density in the foot pads. Together the results prompt the use of carvedilol along with chemotherapy with oxaliplatin to prevent the peripheral neuropathy. - Graphical abstract: Schematic representation neuroprotective mechanisms of carvedilol in oxaliplatin-induced peripheral neuropathy. - Highlights: • Oxaliplatin-induced mitochondrial dysfunction causes neurotoxicity. • Mitochondrial dysfunction leads to bioenergetic and functional deficits. • Carvedilol alleviated oxaliplatin-induced behavioural and functional changes. • Targeting mitochondria with carvedilol attenuated neuropathic pain.

Carvedilol prevents functional deficits in peripheral nerve mitochondria of rats with oxaliplatin-evoked painful peripheral neuropathy

Energy Technology Data Exchange (ETDEWEB)

Areti, Aparna; Komirishetty, Prashanth; Kumar, Ashutosh, E-mail: ashutosh.niperhyd@gov.in

2017-05-01

Oxaliplatin use as chemotherapeutic agent is frequently limited by cumulative neurotoxicity which may compromise quality of life. Reports relate this neurotoxic effect to oxidative stress and mitochondrial dysfunction in peripheral nerves and dorsal root ganglion (DRG). Carvedilol is an antihypertensive drug, has also been appreciated for its antioxidant and mitoprotective properties. Carvedilol co-treatment did not reduce the anti-tumor effects of oxaliplatin in human colon cancer cells (HT-29), but exhibited free radical scavenging activity against oxaliplatin-induced oxidative stress in neuronal cells (Neuro-2a). Hence, the present study was designed to investigate the effect of carvedilol in the experimental model of oxaliplatin-induced peripheral neuropathy (OIPN) in Sprague-Dawley rats. Oxaliplatin reduced the sensory nerve conduction velocity and produced the thermal and mechanical nociception. Carvedilol significantly (P < 0.001) attenuated these functional and sensorimotor deficits. It also counteracted oxidative/nitrosative stress by reducing the levels of nitrotyrosine and improving the mitochondrial superoxide dismutase expression in both sciatic nerve and DRG tissues. It improved the mitochondrial function and prevented the oxaliplatin-induced alteration in mitochondrial membrane potential in sciatic nerve thus prevented loss of intra epidermal nerve fiber density in the foot pads. Together the results prompt the use of carvedilol along with chemotherapy with oxaliplatin to prevent the peripheral neuropathy. - Graphical abstract: Schematic representation neuroprotective mechanisms of carvedilol in oxaliplatin-induced peripheral neuropathy. - Highlights: • Oxaliplatin-induced mitochondrial dysfunction causes neurotoxicity. • Mitochondrial dysfunction leads to bioenergetic and functional deficits. • Carvedilol alleviated oxaliplatin-induced behavioural and functional changes. • Targeting mitochondria with carvedilol attenuated neuropathic pain.

Registry Assessment of Peripheral Interventional Devices (RAPID)　- Registry Assessment of Peripheral Interventional Devices Core Data Elements.

Science.gov (United States)

Jones, W Schuyler; Krucoff, Mitchell W; Morales, Pablo; Wilgus, Rebecca W; Heath, Anne H; Williams, Mary F; Tcheng, James E; Marinac-Dabic, J Danica; Malone, Misti L; Reed, Terrie L; Fukaya, Rie; Lookstein, Robert; Handa, Nobuhiro; Aronow, Herbert D; Bertges, Daniel J; Jaff, Michael R; Tsai, Thomas T; Smale, Joshua A; Zaugg, Margo J; Thatcher, Robert J; Cronenwett, Jack L; Nc, Durham; Md, Silver Spring; Japan, Tokyo; Ny, New York; Ri, Providence; Vt, Burlington; Mass, Newton; Colo, Denver; Ariz, Tempe; Calif, Santa Clara; Minn, Minneapolis; Nh, Lebanon

2018-01-25

The current state of evaluating patients with peripheral artery disease and more specifically of evaluating medical devices used for peripheral vascular intervention (PVI) remains challenging because of the heterogeneity of the disease process, the multiple physician specialties that perform PVI, the multitude of devices available to treat peripheral artery disease, and the lack of consensus about the best treatment approaches. Because PVI core data elements are not standardized across clinical care, clinical trials, and registries, aggregation of data across different data sources and physician specialties is currently not feasible.Methods and Results:Under the auspices of the U.S. Food and Drug Administration's Medical Device Epidemiology Network initiative-and its PASSION (Predictable and Sustainable Implementation of the National Registries) program, in conjunction with other efforts to align clinical data standards-the Registry Assessment of Peripheral Interventional Devices (RAPID) workgroup was convened. RAPID is a collaborative, multidisciplinary effort to develop a consensus lexicon and to promote interoperability across clinical care, clinical trials, and national and international registries of PVI. The current manuscript presents the initial work from RAPID to standardize clinical data elements and definitions, to establish a framework within electronic health records and health information technology procedural reporting systems, and to implement an informatics-based approach to promote the conduct of pragmatic clinical trials and registry efforts in PVI. Ultimately, we hope this work will facilitate and improve device evaluation and surveillance for patients, clinicians, health outcomes researchers, industry, policymakers, and regulators.

Design to Robotic Production for Informed Materialization Processes

Directory of Open Access Journals (Sweden)

Sina Mostafavi

2017-12-01

Full Text Available Design to Robotic Production (D2RP establishes links between digital design and production in order to achieve informed materialization at an architectural scale. D2RP research is being discussed under the computation, automation and materialization themes, by reference to customizable digital design means, robotic fabrication setups and informed materialization strategies implemented by the Robotic Building group at Hyperbody, TU Delft.

Registry Assessment of Peripheral Interventional Devices (RAPID): Registry assessment of peripheral interventional devices core data elements.

Science.gov (United States)

Jones, W Schuyler; Krucoff, Mitchell W; Morales, Pablo; Wilgus, Rebecca W; Heath, Anne H; Williams, Mary F; Tcheng, James E; Marinac-Dabic, J Danica; Malone, Misti L; Reed, Terrie L; Fukaya, Rie; Lookstein, Robert A; Handa, Nobuhiro; Aronow, Herbert D; Bertges, Daniel J; Jaff, Michael R; Tsai, Thomas T; Smale, Joshua A; Zaugg, Margo J; Thatcher, Robert J; Cronenwett, Jack L

2018-02-01

The current state of evaluating patients with peripheral artery disease and more specifically of evaluating medical devices used for peripheral vascular intervention (PVI) remains challenging because of the heterogeneity of the disease process, the multiple physician specialties that perform PVI, the multitude of devices available to treat peripheral artery disease, and the lack of consensus about the best treatment approaches. Because PVI core data elements are not standardized across clinical care, clinical trials, and registries, aggregation of data across different data sources and physician specialties is currently not feasible. Under the auspices of the U.S. Food and Drug Administration's Medical Device Epidemiology Network initiative-and its PASSION (Predictable and Sustainable Implementation of the National Registries) program, in conjunction with other efforts to align clinical data standards-the Registry Assessment of Peripheral Interventional Devices (RAPID) workgroup was convened. RAPID is a collaborative, multidisciplinary effort to develop a consensus lexicon and to promote interoperability across clinical care, clinical trials, and national and international registries of PVI. The current manuscript presents the initial work from RAPID to standardize clinical data elements and definitions, to establish a framework within electronic health records and health information technology procedural reporting systems, and to implement an informatics-based approach to promote the conduct of pragmatic clinical trials and registry efforts in PVI. Ultimately, we hope this work will facilitate and improve device evaluation and surveillance for patients, clinicians, health outcomes researchers, industry, policymakers, and regulators. Copyright © 2017 Society for Vascular Surgery. All rights reserved.

Evaluation of technical design of advanced information display

Energy Technology Data Exchange (ETDEWEB)

Cha, Woo Chang; Kang, Young Ju; Ji, Jung Hun; Jang, Sung Pil; Jung, Sung Hae [Kumoh National Institute of Technology, Gumi (Korea, Republic of)

2003-03-15

The performance of human machine system such as nuclear power plant is highly dependent on the suitability of the interface design of the system. As the computer technology is highly developed, the mental model of computer users including NPP operators has been changed from analogue display type-based stereotype to digitalized one. Therefore, it is necessary and confident to consider the issues to evaluate system suitability of advanced information display on CRT or CBP (Computer Based Procedure). This document is intended for providing an updated and expanded set of user-interface guidelines that meet the needs of designing information display on CRT by finding the generic guidelines involving information display design issues as much as possible. The design Issues and resolutions from the finding may provide the cues for the designers and evaluators of the specific man machine interfaces of digitalized devices.

Evaluation of technical design of advanced information display

International Nuclear Information System (INIS)

Cha, Woo Chang; Kang, Young Ju; Ji, Jung Hun; Jang, Sung Pil; Jung, Sung Hae

2003-03-01

The performance of human machine system such as nuclear power plant is highly dependent on the suitability of the interface design of the system. As the computer technology is highly developed, the mental model of computer users including NPP operators has been changed from analogue display type-based stereotype to digitalized one. Therefore, it is necessary and confident to consider the issues to evaluate system suitability of advanced information display on CRT or CBP (Computer Based Procedure). This document is intended for providing an updated and expanded set of user-interface guidelines that meet the needs of designing information display on CRT by finding the generic guidelines involving information display design issues as much as possible. The design Issues and resolutions from the finding may provide the cues for the designers and evaluators of the specific man machine interfaces of digitalized devices

3D Neuro-electronic interface devices for neuromuscular control: Design studies and realisation steps

NARCIS (Netherlands)

Rutten, Wim; Frieswijk, Theo A.; Frieswijk, T.A.; Smit, J.P.A.; Rozijn, T.H.; Rozijn, Tom H.; Meier, J.H.; Meier, Jan H.

1995-01-01

In order to design the shape and dimensions of new 3D multi-microelectrode information transducers properly, i. e. adapted to the scale of information delivery to and from peripheral nerve fibres, a number of studies were, and still are, being performed on modelling and simulation of electrical

Analysis and design of nuclear energy information systems

International Nuclear Information System (INIS)

Yohanes Dwi Anggoro; Sriyana; Arief Tris Yuliyanto; Wiku Lulus Widodo

2015-01-01

Management of research reports and activities of the Center for Nuclear Energy System Assessment (PKSEN), either in the form of documents and the results of other activities, are important part of the series of activities PKSEN mission achievement. Management of good documents will facilitate the provision of improved inputs or use the maximum results. But over the past few years, there are still some problem in the management of research reports and activities performed by PKSEN. The purpose of this study is to analyze and design flow layout of the Nuclear Energy Information System to facilitate the implementation of the Nuclear Energy Information System. In addition to be used as a research management system and PKSEN activities, it can also be used as information media for the community. Nuclear Energy Information System package is expected to be ''one gate systems for PKSEN information. The research methodology used are: (i) analysis of organizational systems, (ii) the analysis and design of information systems; (iii) the analysis and design of software systems; (iv) the analysis and design of database systems. The results of this study are: had identified and resources throughout the organization PKSEN activation, had analyzed the application of SIEN using SWOT analysis, had identified several types of devices required, had been compiled hierarchy of SIEN, had determined that the database system used is a centralized database system and had elections MySQL as DBMS. The result is a basic design of the Nuclear Energy Information System) which will used as a research and activities management system of PKSEN and also can be used as a medium of information for the community. (author)

Information management systems improve advanced plant design

International Nuclear Information System (INIS)

Turk, R.S.; Serafin, S.A.; Leckley, J.B.

1994-01-01

Computer-aided engineering tools are proving invaluable in both the design and operation of nuclear power plants. ABB Combustion Engineering's Advanced Light Water Reactor (ALWR) features a computerized Information Management System (IMS) as an integral part of the design. The System 80+IMS represents the most powerful information management tool for Nuclear Power Plants commercially available today. Developed by Duke Power Company specifically for use by nuclear power plant owner operators, the IMS consists of appropriate hardware and software to manage and control information flow for all plant related work or tasks in a systematic, consistent, coordinated and informative manner. A significant feature of this IMS is that it is primarily based on plant data. The principal design tool, PASCE (Plant Application and Systems from Combustion Engineering), is comprised of intelligent databases that describe the design and from which accurate plant drawings are created. Additionally the IMS includes, at its hub, a relational database management system and an associated document management system. The data-based approach and applications associated with the IMS were developed, and have proven highly effective, for plant modifications, configuration management, and operations and maintenance applications at Duke Power Company's operating nuclear plants. This paper presents its major features and benefits. 4 refs

Using optic flow in the far peripheral field.

Science.gov (United States)

McManus, Meaghan; D'Amour, Sarah; Harris, Laurence R

2017-07-01

Self-motion information can be used to update spatial memory of location through an estimate of a change in position. Viewing optic flow alone can create Illusory self-motion or "vection." Early studies suggested that peripheral vision is more effective than central vision in evoking vection, but controlling for retinal area and perceived distance suggests that all retinal areas may be equally effective. However, the contributions of the far periphery, beyond 90°, have been largely neglected. Using a large-field Edgeless Graphics Geometry display (EGG, Christie, Canada, field of view ±112°) and systematically blocking central (±20° to ±90°) or peripheral (viewing through tunnels ±20° to ±40°) parts of the field, we compared the effectiveness of different retinal regions at evoking forwards linear vection. Fifteen participants indicated when they had reached the position of a previously presented target after visually simulating motion down a simulated corridor. The amount of simulated travel needed to match a given target distance was modelled with a leaky spatial integrator model to estimate gains (perceived/actual distance) and a spatial decay factor. When optic flow was presented only in the far periphery (beyond 90°) gains were significantly higher than for the same motion presented full field or in only the central field, resulting in accurate performance in the range of speeds associated with normal walking. The increased effectiveness of optic flow in the peripheral field alone compared to full-field motion is discussed in terms of emerging neurophysiological studies that suggest brain areas dedicated to processing information from the far peripheral field.

Environment, information divide and design

International Nuclear Information System (INIS)

Iwata, Shuichi

2007-01-01

Design of human environment is to be made with understanding human-human and human-environment relations and environmental behaviors of human beings, artifacts and natural things and overcoming their differences and contradictions. Information divide exists naturally due to various differences of human beings. Many problems in the area of nuclear energy seem to be derived from various differences and contradictions in central-local interests, between the particles concerned and unconcerned and also in human being-artifacts relations. In order to harmonize nuclear energy with the society, it is necessary to vanish differences and solve contradictions with redesigning environments of those problems in their context. Case studies are highly recommended with continuous efforts to develop more universal design methodology. Open access to information and data in science and technology is encouraged in the area of nuclear energy. (T. Tanaka)

Factors predicting walking intolerance in patients with peripheral ...

African Journals Online (AJOL)

Objective. To determine which physiological variables conduce to walking intolerance in patients with peripheral arterial disease (PAD). Design. The physiological response to a graded treadmill exercise test (GTT) in patients with PAD was characterised. Setting. Patients were recruited from the Department of. Vascular ...

Design and Management of Networked Information Systems

DEFF Research Database (Denmark)

Havn, Erling; Bansler, Jørgen P.

1996-01-01

In this paper, we present a newly started research project at the Center for Tele-Information at the Technical University of Denmark. The project focuses on the design and management of networked information systems, that is computer-based IS linked by a wide area network and supporting...... research questions:1. What is the essence of the new managerial theories and models and how do they define the role of telecommunications and IT in organizations?2. How are these organizational theories and models implemented in practice?3. How is the design and implementation of information systems...... and networks actually organized and carried out?4. What are the consequences for work content, skills, working conditions, etc.? The research project consists of a theoretical analysis of contemporary management theories as well as a number of in-depth case studies of firms engaged in the design...

Implementing risk-informed life-cycle design

International Nuclear Information System (INIS)

Hill, Ralph S. III

2007-01-01

This paper describes a design process based on risk-informed probabilistic methodologies that cover a facility's life-cycle from start of conceptual design through decontamination and decommissioning. The concept uses probabilistic risk assessments to identify target reliabilities for facility systems and components. Target reliabilities are used in system and subsystem simulation analyses to determine the optimum combination of initial system and component construction reliability, maintenance frequency, and inspection frequency for both active and passive components. The target reliabilities are also used for system based code margin exchange to reduce excessive level of margins to appropriate levels resulting in a more flexible structure of codes and standards that improves facility reliability and cost. The paper includes a description of a risk informed life-cycle design process, a summary of work being done, and a discussion of work needed to implement the process. (author)

Key Design Properties for Shipping Information Pipeline

DEFF Research Database (Denmark)

Jensen, Thomas; Tan, Yao-Hua

2015-01-01

on paper, e-mail, phone and text message, and far too costly. This paper explores the design properties for a shared information infrastructure to exchange information between all parties in the supply chain, commercial parties as well as authorities, which is called a Shipping Information Pipeline...

Drug-induced peripheral neuropathy

DEFF Research Database (Denmark)

Vilholm, Ole Jakob; Christensen, Alex Alban; Zedan, Ahmed

2014-01-01

Peripheral neuropathy can be caused by medication, and various descriptions have been applied for this condition. In this MiniReview, the term 'drug-induced peripheral neuropathy' (DIPN) is used with the suggested definition: Damage to nerves of the peripheral nervous system caused by a chemical...... substance used in the treatment, cure, prevention or diagnosis of a disease. Optic neuropathy is included in this definition. A distinction between DIPN and other aetiologies of peripheral neuropathy is often quite difficult and thus, the aim of this MiniReview is to discuss the major agents associated...

Peripheral retinal degenerations and the risk of retinal detachment.

Science.gov (United States)

Lewis, Hilel

2003-07-01

To review the degenerative diseases of the peripheral retina in relationship with the risk to develop a rhegmatogenous retinal detachment and to present recommendations for use in eyes at increased risk of developing a retinal detachment. Focused literature review and author's clinical experience. Retinal degenerations are common lesions involving the peripheral retina, and most of them are clinically insignificant. Lattice degeneration, degenerative retinoschisis, cystic retinal tufts, and, rarely, zonular traction tufts, can result in a rhegmatogenous retinal detachment. Therefore, these lesions have been considered for prophylactic therapy; however, adequate studies have not been performed to date. Well-designed, prospective, randomized clinical studies are necessary to determine the benefit-risk ratio of prophylactic treatment. In the meantime, the evidence available suggests that most of the peripheral retinal degenerations should not be treated except in rare, high-risk situations.

Zilog UPC, a higher performance slave peripheral controller

Energy Technology Data Exchange (ETDEWEB)

Walters, S.M.

1982-01-01

The universal peripheral controllers Z8090 and Z8590 (UPC) is an intelligent peripheral controller. It may be mask-programmed to execute dedicated I/O tasks that would otherwise need to be done by the host microprocessor. The UPC is actually a single-chip microcomputer with a complete host bus interface on-chip. It offers the hardware features of a programmable parallel I/O port, a programmable counter/timer, an I/O buffer RAM, and an intelligent interrupt controller. In addition, it provides a stored program processing element that is capable of pre-processing information before it is transferred to the host. Perhaps as important as its features is the fact that when used in volume, the UPC will be comparable in cost to non-programmable LSI parallel I/O and counter/timer functions. The UPC, simply stated, offers a cost effective multi-processor approach for offloading the host microprocessor of routine peripheral control tasks in high volume applications.

Cost information in succeeding stages of the design process

NARCIS (Netherlands)

Tempelmans Plat, H.; Deiman, E.P.; Beheshti, M.R.; Zreik, K.

1993-01-01

Adequate decision making in the design process needs information about oost oonsequences over the life of the designed object. In succeeding stages the types of decisions change; as a consequence the type of oost information will differ as well. For each stage oost information about realized

Design of Collaborative Information Agents

NARCIS (Netherlands)

Jonker, C.M.; Klusch, M.; Treur, J.; Klusch, M.; Kerschberg, L.

2000-01-01

Effective development of nontrivial systems of collaborative information agents requires that an in-depth analysis is made resulting in (1) specification of requirements at different levels of the system, (2) specification of design structures, and (3) a systematic verification. To support a

Chinese herbal medicine for diabetic peripheral neuropathy.

Science.gov (United States)

Chen, Wei; Zhang, Yin; Li, Xinxue; Yang, Guoyan; Liu, Jian Ping

2013-10-06

Chinese herbal medicine is frequently used for treating diabetic peripheral neuropathy in China. Many controlled trials have been undertaken to investigate its efficacy.This is an update of a Cochrane review that was first published in the year 2011. To assess the beneficial effects and harms of Chinese herbal medicine for people with diabetic peripheral neuropathy. On 14 May 2012, we searched the Cochrane Neuromuscular Disease Group Specialized Register CENTRAL (2012, Issue 4 in The Cochrane Library), MEDLINE (January 1966 to May 2012), EMBASE (January 1980 to May 2012), AMED (January 1985 to May 2012) and in October 2012, the Chinese Biomedical Database (CBM) (1979 to October 2012), Chinese National Knowledge Infrastructure Database (CNKI) (1979 to October 2012), and VIP Chinese Science and Technique Journals Database (1989 to October 2012). We searched for unpublished literature in the Chinese Conference Papers Database, and Chinese Dissertation Database (from inception to October 2012). There were no language or publication restrictions. We included randomised controlled trials of Chinese herbal medicine (with a minimum of four weeks treatment duration) for people with diabetic peripheral neuropathy compared with placebo, no intervention, or conventional interventions. Trials of herbal medicine plus a conventional drug versus the drug alone were also included. Two authors independently extracted data and evaluated trial quality. We contacted study authors for additional information. Forty-nine randomised trials involving 3639 participants were included. All trials were conducted and published in China. Thirty-eight different herbal medicines were tested in these trials, including four single herbs (extracts from a single herb), eight traditional Chinese patent medicines, and 26 self concocted Chinese herbal compound prescriptions. The trials reported on global symptom improvement (including improvement in numbness or pain) and changes in nerve conduction

3D-engineering of Cellularized Conduits for Peripheral Nerve Regeneration

Science.gov (United States)

Hu, Yu; Wu, Yao; Gou, Zhiyuan; Tao, Jie; Zhang, Jiumeng; Liu, Qianqi; Kang, Tianyi; Jiang, Shu; Huang, Siqing; He, Jiankang; Chen, Shaochen; Du, Yanan; Gou, Maling

2016-08-01

Tissue engineered conduits have great promise for bridging peripheral nerve defects by providing physical guiding and biological cues. A flexible method for integrating support cells into a conduit with desired architectures is wanted. Here, a 3D-printing technology is adopted to prepare a bio-conduit with designer structures for peripheral nerve regeneration. This bio-conduit is consisted of a cryopolymerized gelatin methacryloyl (cryoGelMA) gel cellularized with adipose-derived stem cells (ASCs). By modeling using 3D-printed “lock and key” moulds, the cryoGelMA gel is structured into conduits with different geometries, such as the designed multichannel or bifurcating and the personalized structures. The cryoGelMA conduit is degradable and could be completely degraded in 2-4 months in vivo. The cryoGelMA scaffold supports the attachment, proliferation and survival of the seeded ASCs, and up-regulates the expression of their neurotrophic factors mRNA in vitro. After implanted in a rat model, the bio-conduit is capable of supporting the re-innervation across a 10 mm sciatic nerve gap, with results close to that of the autografts in terms of functional and histological assessments. The study describes an indirect 3D-printing technology for fabricating cellularized designer conduits for peripheral nerve regeneration, and could lead to the development of future nerve bio-conduits for clinical use.

Evaluation of technical design of advanced information display(III)

International Nuclear Information System (INIS)

Cha, Woo Chang; Jung, Sung Hae; Park, Joon Yong; Kim, Nam Cheol; Park, Soon Hyuk

2005-02-01

As the computer technology is highly developed, the mental model of computer users including NPP operators has been changed from analogue display type-based stereotype to digitalized one. Therefore, it is necessary and confident to consider the issues to evaluate system suitability of advanced information display on visual display terminal. This document is intended for providing an updated and expanded set of user-interface guidelines that meet the needs of designing digitalized information display by finding the generic guidelines involving information display design issues, and the relationship among the guidelines. The design issues and resolutions from the finding may provide the cues for the designers and evaluators of the specific man machine interfaces of digitalized devices. The Design Review Supporting System for Advanced Information Display(DReSS-AID) was developed for the practical usage of evaluators-in-field, which was implemented with Hangul version guidelines

Evaluation of technical design of advanced information display(III)

Energy Technology Data Exchange (ETDEWEB)

Cha, Woo Chang; Jung, Sung Hae; Park, Joon Yong; Kim, Nam Cheol [Kumoh National Institute of Technology, Gumi (Korea, Republic of); Park, Soon Hyuk [DNT Inc., Daejeon (Korea, Republic of)

2005-02-15

As the computer technology is highly developed, the mental model of computer users including NPP operators has been changed from analogue display type-based stereotype to digitalized one. Therefore, it is necessary and confident to consider the issues to evaluate system suitability of advanced information display on visual display terminal. This document is intended for providing an updated and expanded set of user-interface guidelines that meet the needs of designing digitalized information display by finding the generic guidelines involving information display design issues, and the relationship among the guidelines. The design issues and resolutions from the finding may provide the cues for the designers and evaluators of the specific man machine interfaces of digitalized devices. The Design Review Supporting System for Advanced Information Display(DReSS-AID) was developed for the practical usage of evaluators-in-field, which was implemented with Hangul version guidelines.

Multi-microelectrode devices for intrafascicular use in peripheral nerve

NARCIS (Netherlands)

Rutten, Wim

1996-01-01

This minisymposium paper gives an overview of experimental, modeling, design and microfabrication steps which lead towards the University of Twente three-dimensional 128-fold silicon microelectrode device. The device is meant for implantation in peripheral nerve for neuromuscular control purposes

Peripheral arterial disease and intermittent claudication: Efficacy of ...

African Journals Online (AJOL)

Objective. To compare the effect of two training programmes and advice to exercise at home on physiological adaptations in patients with peripheral arterial disease (PAD). Design. 30 patients with a typical history of PAD and intermittent claudication were randomised to either an upper body strength training programme ...

Information delivery manuals to integrate building product information into design

DEFF Research Database (Denmark)

Berard, Ole Bengt; Karlshøj, Jan

2011-01-01

Despite continuing BIM progress, professionals in the AEC industry often lack the information they need to perform their work. Although this problem could be alleviated by information systems similar to those in other industries, companies struggle to model processes and information needs...... them in information systems. BIM implies that objects are bearers of information and logic. The present study has three main aims: (1) to explore IDMs capability to capture all four perspectives, (2) to determine whether an IDM’s collaborative methodology is valid for developing standardized processes......, and (3) to ascertain whether IDM’s business rules can support the development of information and logic-bearing BIM objects. The research is based on a case study of re-engineering the bidding process for a design-build project to integrate building product manufacturers, subcontractors...

Electrophysiological measurements of diabetic peripheral neuropathy: A systematic review.

Science.gov (United States)

Shabeeb, Dheyauldeen; Najafi, Masoud; Hasanzadeh, Gholamreza; Hadian, Mohammed Reza; Musa, Ahmed Eleojio; Shirazi, Alireza

2018-03-28

Peripheral neuropathy is one of the main complications of diabetes mellitus. One of the features of diabetic nerve damage is abnormality of sensory and motor nerve conduction study. An electrophysiological examination can be reproduced and is also a non-invasive approach in the assessment of peripheral nerve function. Population-based and clinical studies have been conducted to validate the sensitivity of these methods. When the diagnosis was based on clinical electrophysiological examination, abnormalities were observed in all patients. In this research, using a review design, we reviewed the issue of clinical electrophysiological examination of diabetic peripheral neuropathy in articles from 2008 to 2017. For this purpose, PubMed, Scopus and Embase databases of journals were used for searching articles. The researchers indicated that diabetes (both types) is a very disturbing health issue in the modern world and should be given serious attention. Based on conducted studies, it was demonstrated that there are different procedures for prevention and treatment of diabetes-related health problems such as diabetic polyneuropathy (DPN). The first objective quantitative indication of the peripheral neuropathy is abnormality of sensory and motor nerve conduction tests. Electrophysiology is accurate, reliable and sensitive. It can be reproduced and also is a noninvasive approach in the assessment of peripheral nerve function. The methodological review has found that the best method for quantitative indication of the peripheral neuropathy compared with all other methods is clinical electrophysiological examination. For best results, standard protocols such as temperature control and equipment calibration are recommended. Copyright © 2018. Published by Elsevier Ltd.

An Ethnographically Informed Participatory Design of Primary Healthcare Information Technology in a Developing Country Setting.

Science.gov (United States)

Shidende, Nima Herman; Igira, Faraja Teddy; Mörtberg, Christina Margaret

2017-01-01

Ethnography, with its emphasis on understanding activities where they occur, and its use of qualitative data gathering techniques rich in description, has a long tradition in Participatory Design (PD). Yet there are limited methodological insights in its application in developing countries. This paper proposes an ethnographically informed PD approach, which can be applied when designing Primary Healthcare Information Technology (PHIT). We use findings from a larger multidisciplinary project, Health Information Systems Project (HISP) to elaborate how ethnography can be used to facilitate participation of health practitioners in developing countries settings as well as indicating the importance of ethnographic approach to participatory Health Information Technology (HIT) designers. Furthermore, the paper discusses the pros and cons of using an ethnographic approach in designing HIT.

Studying Design Engineers Use Of Information Systems

DEFF Research Database (Denmark)

Restrepo-Giraldo, John Dairo

2006-01-01

Studying information usage by design engineers involves considering technical, social, cognitive and volitional factors. This makes it challenging, especially for researchers without a cognitive psychology background. This paper presents a summary of key findings in researching information use...

The Elaboration Likelihood Model and Proxemic Violations as Peripheral Cues to Information Processing.

Science.gov (United States)

Eaves, Michael

This paper provides a literature review of the elaboration likelihood model (ELM) as applied in persuasion. Specifically, the paper addresses distraction with regard to effects on persuasion. In addition, the application of proxemic violations as peripheral cues in message processing is discussed. Finally, the paper proposes to shed new light on…

Designing an oil spill information management system

International Nuclear Information System (INIS)

Douligeris, C.; Collins, J.; Iakovou, E.; Sun, P.; Riggs, K.R.

1995-01-01

This paper presents the architectural design of OSIMS, an Oil Spill Information Management System, which is an integrated information management tool that consists of an object-relational database management system, an adaptive decision support system, an advanced visualization system (AVS) and a geographic information system (GIS). OSIMS will handle large and diverse databases of environmental, ecological, geographical, engineering, and regulatory information and will be used for risk analysis and contingency planning

Designing an oil spill information management system

Energy Technology Data Exchange (ETDEWEB)

Douligeris, C.; Collins, J.; Iakovou, E.; Sun, P.; Riggs, K.R. [Univ. of Miami, Coral Gables, FL (United States)

1995-12-31

This paper presents the architectural design of OSIMS, an Oil Spill Information Management System, which is an integrated information management tool that consists of an object-relational database management system, an adaptive decision support system, an advanced visualization system (AVS) and a geographic information system (GIS). OSIMS will handle large and diverse databases of environmental, ecological, geographical, engineering, and regulatory information and will be used for risk analysis and contingency planning.

Propylthiouracil and peripheral neuropathy

Directory of Open Access Journals (Sweden)

Valentina Van Boekel

1992-06-01

Full Text Available Peripheral neuropathy is a rare manifestation in hyperthyroidism. We describe the neurological manifestations of a 38 year old female with Graves' disease who developed peripheral neuropathy in the course of her treatment with propylthiouracil. After the drug was tapered off, the neurological signs disappeared. Therefore, we call attention for a possible toxic effect on peripheral nervous system caused by this drug.

Value-informed space systems design and acquisition

Science.gov (United States)

Brathwaite, Joy

Investments in space systems are substantial, indivisible, and irreversible, characteristics that make them high-risk, especially when coupled with an uncertain demand environment. Traditional approaches to system design and acquisition, derived from a performance- or cost-centric mindset, incorporate little information about the spacecraft in relation to its environment and its value to its stakeholders. These traditional approaches, while appropriate in stable environments, are ill-suited for the current, distinctly uncertain, and rapidly changing technical and economic conditions; as such, they have to be revisited and adapted to the present context. This thesis proposes that in uncertain environments, decision-making with respect to space system design and acquisition should be value-based, or at a minimum value-informed. This research advances the value-centric paradigm by providing the theoretical basis, foundational frameworks, and supporting analytical tools for value assessment of priced and unpriced space systems. For priced systems, stochastic models of the market environment and financial models of stakeholder preferences are developed and integrated with a spacecraft-sizing tool to assess the system's net present value. The analytical framework is applied to a case study of a communications satellite, with market, financial, and technical data obtained from the satellite operator, Intelsat. The case study investigates the implications of the value-centric versus the cost-centric design and acquisition choices. Results identify the ways in which value-optimal spacecraft design choices are contingent on both technical and market conditions, and that larger spacecraft for example, which reap economies of scale benefits, as reflected by their decreasing cost-per-transponder, are not always the best (most valuable) choices. Market conditions and technical constraints for which convergence occurs between design choices under a cost-centric and a value

Peripheral vision benefits spatial learning by guiding eye movements.

Science.gov (United States)

Yamamoto, Naohide; Philbeck, John W

2013-01-01

The loss of peripheral vision impairs spatial learning and navigation. However, the mechanisms underlying these impairments remain poorly understood. One advantage of having peripheral vision is that objects in an environment are easily detected and readily foveated via eye movements. The present study examined this potential benefit of peripheral vision by investigating whether competent performance in spatial learning requires effective eye movements. In Experiment 1, participants learned room-sized spatial layouts with or without restriction on direct eye movements to objects. Eye movements were restricted by having participants view the objects through small apertures in front of their eyes. Results showed that impeding effective eye movements made subsequent retrieval of spatial memory slower and less accurate. The small apertures also occluded much of the environmental surroundings, but the importance of this kind of occlusion was ruled out in Experiment 2 by showing that participants exhibited intact learning of the same spatial layouts when luminescent objects were viewed in an otherwise dark room. Together, these findings suggest that one of the roles of peripheral vision in spatial learning is to guide eye movements, highlighting the importance of spatial information derived from eye movements for learning environmental layouts.

Peripheral Neuropathy: Symptoms and Signs

Science.gov (United States)

... Utah Research News Make a Difference Symptoms of Peripheral Neuropathy Print This Page Peripheral Neuropathy symptoms usually start ... more slowly over many years. The symptoms of peripheral neuropathy often include: A sensation of wearing an invisible “ ...

Control of peripheral units by satellite computer

International Nuclear Information System (INIS)

Tran, K.T.

1974-01-01

A computer system was developed allowing the control of nuclear physics experiments, and use of the results by means of graphical and conversational assemblies. This system which is made of two computers, one IBM-370/135 and one Telemecanique Electrique T1600, controls the conventional IBM peripherals and also the special ones made in the laboratory, such as data acquisition display and graphics units. The visual display is implemented by a scanning-type television, equipped with a light-pen. These units in themselves are universal, but their specifications were established to meet the requirements of nuclear physics experiments. The input-output channels of the two computers have been connected together by an interface, designed and implemented in the Laboratory. This interface allows the exchange of control signals and data (the data are changed from bytes into word and vice-versa). The T1600 controls the peripherals mentionned above according to the commands of the IBM370. Hence the T1600 has here the part of a satellite computer which allows conversation with the main computer and also insures the control of its special peripheral units [fr

Mobility-Related Consequences of Reduced Lower-Extremity Peripheral Nerve Function with Age

DEFF Research Database (Denmark)

Ward, Rachel E; Caserotti, P.; Cauley, Jane A

2016-01-01

-dwelling and institutionalized residents, 1 from a range of residential locations, and 1 of patients with peripheral arterial disease. Mean ages ranged from 71-82 years. Nerve function was assessed by vibration threshold (n=2); sensory measures and clinical signs and symptoms of neuropathy (n=2); motor nerve conduction (n=1......The objective of this study is to systematically review the relationship between lower-extremity peripheral nerve function and mobility in older adults. The National Library of Medicine (PubMed) was searched on March 23, 2015 with no limits on publication dates. One reviewer selected original...... research studies of older adults (>= 65 years) that assessed the relationship between lower-extremity peripheral nerve function and mobility-related outcomes. Participants, study design and methods of assessing peripheral nerve impairment were evaluated and results were reported and synthesized. Eight...

Using Dedal to share and reuse distributed engineering design information

Science.gov (United States)

Baya, Vinod; Baudin, Catherine; Mabogunje, Ade; Das, Aseem; Cannon, David M.; Leifer, Larry J.

1994-01-01

The overall goal of the project is to facilitate the reuse of previous design experience for the maintenance, repair and redesign of artifacts in the electromechanical engineering domain. An engineering team creates information in the form of meeting summaries, project memos, progress reports, engineering notes, spreadsheet calculations and CAD drawings. Design information captured in these media is difficult to reuse because the way design concepts are referred to evolve over the life of a project and because decisions, requirements and structure are interrelated but rarely explicitly linked. Based on protocol analysis of the information seeking behavior of designer's, we defined a language to describe the content and the form of design records and implemented this language in Dedal, a tool for indexing, modeling and retrieving design information. We first describe the approach to indexing and retrieval in Dedal. Next we describe ongoing work in extending Dedal's capabilities to a distributed environment by integrating it with World Wide Web. This will enable members of a design team who are not co-located to share and reuse information.

Homeward Bound: Ecological Design of Domestic Information Systems

Science.gov (United States)

Wastell, David G.; Sauer, Juergen S.; Schmeink, Claudia

Information technology artefacts are steadily permeating everyday life, just as they have colonized the business domain. Although research in our field has largely addressed the workplace, researchers are beginning to take an interest in the home environment too. Here, we address the domestic realm, focusing on the design of complex, interactive information systems. As such, our work sits in the design science version rather than behavioral science paradigm of IS research. We argue that the home is in many ways a more challenging environment for the designer than the workplace, making good design of critical importance. Regrettably, the opposite would appear to be the norm. Two experiments are reported, both concerned with the design of the user interface for domestic heating systems. Of note is our use of a medium-fidelity laboratory simulation or "microworld" in this work. Two main substantive findings resulted. First, that ecologically designed feedback, embodying a strong mapping between task goals and system status, produced superior task performance. Second, that predictive decision aids provided clear benefits over other forms of user support, such as advisory systems. General implications for the design of domestic information systems are discussed, followed by reflections on the nature of design work in IS, and on the design science project itself. It is concluded that the microworld approach has considerable potential for developing IS design theory. The methodological challenges of design research are highlighted, especially the presence of additional validity threats posed by the need to construct artefacts in order to evaluate theory. It is argued that design theory is necessarily complex, modal, and uncertain, and that design science (like design itself) should be prosecuted in an open, heuristic spirit, drawing more on the proven methods of "good design" (e.g.,prototyping, user participation) in terms of its own praxis.

Auditory and visual reaction time and peripheral field of vision in helmet users

Directory of Open Access Journals (Sweden)

Abbupillai Adhilakshmi

2016-12-01

Full Text Available Background: The incidence of fatal accidents are more in two wheeler drivers compared to four wheeler drivers. Head injury is of serious concern when recovery and prognosis of the patients are warranted, helmets are being used for safety purposes by moped, scooters and motorcycle drivers. Although, helmets are designed with cushioning effect to prevent head injuries but there are evidences of increase risk of neck injuries and reduced peripheral vision and hearing in helmet users. A complete full coverage helmets provide about less than 3 percent restrictions in horizontal peripheral visual field compared to rider without helmet. The standard company patented ergonomically designed helmets which does not affect the peripheral vision neither auditory reaction time. Objective: This pilot study aimed to evaluate the peripheral field of vision and auditory and visual reaction time in a hypertensive, diabetic and healthy male and female in order to have a better insight of protective characteristics of helmet in health and disease. Method: This pilot study carried out on age matched male of one healthy, one hypertensive and one diabetic and female subject of one healthy, one hypertensive and one diabetics. The field of vision was assessed by Lister’s perimeter whereas auditory and visual reaction time was recorded with response analyser. Result : Gender difference was not noted in peripheral field of vision but mild difference was found in auditory reaction time for high frequency and visual reaction time for both red and green colour in healthy control. But lateral and downward peripheral visual field was found reduced whereas auditory and visual reaction time was found increased in both hypertensive and diabetic subject in both sexes. Conclusion: Peripheral vision, auditory reaction time and visual reaction time in hypertensive and diabetics may lead to vulnerable accident. Helmet use has proven to reduce extent of injury in motorcyclist and

Donating Peripheral Blood Stem Cells

Science.gov (United States)

... Print this page My Cart Donating peripheral blood stem cells Peripheral blood stem cell (PBSC) donation is a nonsurgical procedure to collect ... Donating bone marrow Donor experiences videos Peripheral blood stem cell (PBSC) donation is one of two methods of ...

Risk-informed design of a pebble bed gas reactor

International Nuclear Information System (INIS)

Ritterbusch, Stanley; Dimitrijevic, Vesna; Simic Zdenko; Savkina Marina

2003-01-01

One of the major challenges to the successful deployment of new nuclear plants in the United States is the regulatory process, which is largely based on water-reactor design technology and operating experience. While ongoing and expected efforts to license new LWR designs are based primarily on current regulations, guidance, and past experience, the pre-application review of the gas-cooled Pebble Bed Modular Reactor (PBMR) has shown that efforts are being made to provide additional 'risk-informed' improvements to the licensing process. These improvements are aimed at resolving new design and regulatory issues using a plant-wide integrated evaluation method - state-of-the-art Probabilistic Risk Assessment - which addresses all significant design features and operating modes. The integrated PRA evaluation is supported by the usual deterministic design analyses, engineering judgments, and margins added to address uncertainties (i.e., defense-in-depth). The work performed for this paper was completed as part of the United States Department of Energy's Nuclear Energy Research Initiative. The purpose of this particular project was to develop the methods for a new 'highly risk-informed' design and regulatory process. In this work. PRA techniques were applied in order to provide an integrated and systematic analysis of the plant design, to quantify uncertainties and explicitly account for defense-in-depth features. This work concentrates on the application of the risk-informed principles to a new plant design such as the PBMR. The implementation example completed for this project included specification of the design configuration, use of the PRA to evaluate the design, and iterations to identify design changes that improve the overall level of safety and system reliability. This paper summarizes the new 'highly risk-informed' design process, the design of the PBMR, and the results obtained. These results, consistent with the known inherent safety features of a pebble

Design tools for computer-generated display of information to operators

International Nuclear Information System (INIS)

O'Brien, J.F.; Cain, D.G.; Sun, B.K.H.

1985-01-01

More and more computers are being used to process and display information to operators who control nuclear power plants. Implementation of computer-generated displays in power plant control rooms represents a considerable design challenge for industry designers. Over the last several years, the EPRI has conducted research aimed at providing industry designers tools to meet this new design challenge. These tools provide guidance in defining more 'intelligent' information for plant control and in developing effective displays to communicate this information to the operators. (orig./HP)

Contract Design: The problem of information asymmetry

Directory of Open Access Journals (Sweden)

Axel C. Mühlbacher

2018-01-01

Full Text Available Introduction: Integrated care systems are advocated as an effective method of improving the performance of healthcare systems. These systems outline a payment and care delivery model that intends to tie provider reimbursements to predefined quality metrics. Little is known about the contractual design and the main challenges of delegating “accountability” to these new kinds of organisations and/or contracts. The research question in this article focuses on how healthcare contracts can look like and which possible problems arise in designing such contracts. In this a special interest is placed on information asymmetries.  Methods: A comprehensive literature review on methods of designing contracts in Integrated Care was conducted. This article is the first in a row of three that all contribute to a specific issue in designing healthcare contracts. Starting with the organisation of contracts and information asymmetries, part 2 focusses on financial options and risks and part 3 finally concludes with the question of risk management and evaluation.  Results: Healthcare contracting between providers and payers will have a major impact on the overall design of future healthcare systems. If Integrated care systems or any other similar concept of care delivery are to be contracted directly by payers to manage the continuum of care the costs of market utilisation play an essential role. Transaction costs also arise in the course of the negotiation and implementation of contracts. These costs are the reason why it is generally not possible to conclude perfect (complete contracts. Problems with asymmetric distribution of information can relate to the situation before a contract is concluded (adverse selection and after conclusion of a contract (moral hazard.  Discussion and Conclusions: Information asymmetries are seen as a major obstacle to the efficient operation of integrated care programmes. Coordination and motivation problems cannot be solved

Contract Design: The problem of information asymmetry.

Science.gov (United States)

Mühlbacher, Axel C; Amelung, Volker E; Juhnke, Christin

2018-01-12

Integrated care systems are advocated as an effective method of improving the performance of healthcare systems. These systems outline a payment and care delivery model that intends to tie provider reimbursements to predefined quality metrics. Little is known about the contractual design and the main challenges of delegating "accountability" to these new kinds of organisations and/or contracts. The research question in this article focuses on how healthcare contracts can look like and which possible problems arise in designing such contracts. In this a special interest is placed on information asymmetries. A comprehensive literature review on methods of designing contracts in Integrated Care was conducted. This article is the first in a row of three that all contribute to a specific issue in designing healthcare contracts. Starting with the organisation of contracts and information asymmetries, part 2 focusses on financial options and risks and part 3 finally concludes with the question of risk management and evaluation. Healthcare contracting between providers and payers will have a major impact on the overall design of future healthcare systems. If Integrated care systems or any other similar concept of care delivery are to be contracted directly by payers to manage the continuum of care the costs of market utilisation play an essential role. Transaction costs also arise in the course of the negotiation and implementation of contracts. These costs are the reason why it is generally not possible to conclude perfect (complete) contracts. Problems with asymmetric distribution of information can relate to the situation before a contract is concluded (adverse selection) and after conclusion of a contract (moral hazard). Information asymmetries are seen as a major obstacle to the efficient operation of integrated care programmes. Coordination and motivation problems cannot be solved at no-costs. The presented problems in the design of selective individual contracts

Design and analysis of information model hotel complex

Directory of Open Access Journals (Sweden)

Garyaev Nikolai

2016-01-01

Full Text Available The article analyzes the innovation in 3D modeling and development of process design approaches based on visualization of information technology and computer-aided design systems. The problems arising in the modern design and the approach to address them.

Tumors of peripheral nerves

International Nuclear Information System (INIS)

Ho, Michael; Lutz, Amelie M.

2017-01-01

Differentiation between malignant and benign tumors of peripheral nerves in the early stages is challenging; however, due to the unfavorable prognosis of malignant tumors early identification is required. To show the possibilities for detection, differential diagnosis and clinical management of peripheral nerve tumors by imaging appearance in magnetic resonance (MR) neurography. Review of current literature available in PubMed and MEDLINE, supplemented by the authors' own observations in clinical practice. Although not pathognomonic, several imaging features have been reported for a differentiation between distinct peripheral nerve tumors. The use of MR neurography enables detection and initial differential diagnosis in tumors of peripheral nerves. Furthermore, it plays an important role in clinical follow-up, targeted biopsy and surgical planning. (orig.) [de

Evaluation of technical design of advanced information display(II)

International Nuclear Information System (INIS)

Cha, Woo Chang; Kang, Young Ju; Ji, Jung Hun; Jang, Sung Pil; Jung, Sung Hae; Park, Hyun Jin

2004-02-01

As the computer technology is highly developed, the mental model of computer users including NPP operators has been changed from analogue display type-based stereotype to digitalized one. Therefore, it is necessary and confident to consider the issues to evaluate system suitability of advanced information display on visual display terminal such as CRT. This document is intended for providing an updated and expanded set of user-interface guidelines that meet the needs of designing information display on CRT by finding the generic guidelines involving information display design issues, and the relationship among the guidelines. The design issues and resolutions from the finding may provide the cues for the designers and evaluators of the specific man machine interfaces of digitalized devices

Evaluation of technical design of advanced information display(II)

Energy Technology Data Exchange (ETDEWEB)

Cha, Woo Chang; Kang, Young Ju; Ji, Jung Hun; Jang, Sung Pil; Jung, Sung Hae; Park, Hyun Jin [Kumoh National Univ., Gumi (Korea, Republic of)

2004-02-15

As the computer technology is highly developed, the mental model of computer users including NPP operators has been changed from analogue display type-based stereotype to digitalized one. Therefore, it is necessary and confident to consider the issues to evaluate system suitability of advanced information display on visual display terminal such as CRT. This document is intended for providing an updated and expanded set of user-interface guidelines that meet the needs of designing information display on CRT by finding the generic guidelines involving information display design issues, and the relationship among the guidelines. The design issues and resolutions from the finding may provide the cues for the designers and evaluators of the specific man machine interfaces of digitalized devices.

Information management needs for Fort Calhoun's design basis reconstitution project

International Nuclear Information System (INIS)

Beach, D.R.; Erickson, E.A.; Gambhir, S.K.; Parsons, R.D.

1989-01-01

While the need for information management is not new to the nuclear industry or Omaha Public Power District (OPPD), the interrelationship among design information, multiple systems, and design basis issues has necessitated the management of this information in new ways. The project team involved in the reconstitution of the design basis for OPPD's Fort Calhoun nuclear station has experienced the need for the developed effective methods for managing the vast amount of interrelated information associated with this effort. This management of information has been necessary to ensure that design basis documents (DBDs) adequately reflect the interrelated nature of component, system, and plant design; are complete and accurate; and are produced and maintained in a cost-effective manner. Fort Calhoun's aggressive design basis reconstitution project began in early 1987. The present scope of the project includes the production of 52 system and plant level DBDs; currently the project is ∼50% complete with DBDs in various stages of completion, from pilot DBDs through DBDs with approved formats, which have been issued for use. The experience in producing these documents has lead to a growing understanding of the special need for information management in each stage of the project. The development of the information tracking and management processes for the various stages of DBD development has proven to be cost-effective and gives a level of assurance that information has been included in the DBDs consistently and accurately

Peripheral dentinogenic ghost cell tumor

Directory of Open Access Journals (Sweden)

Sushant S Kamat

2013-01-01

Full Text Available Dentinogenic ghost cell tumors (DGCT are uncommon lesions mainly with rare peripheral types. This report presents a case of peripheral DGCT on the left side of the mandibular alveolar ridge of a heavy smoker, a 68-year-old man, with main presenting feature as a mild pain. Submandibular lymphadenopathy and radiological "saucerization" were evident. Differential diagnosis included fibroma, neurofibroma, peripheral ameloblastoma, peripheral odontogenic fibroma, and peripheral giant cell granuloma. Histologically, ameloblastoma-like epithelial elements were seen in association with grouped ghost cells. Proliferating polyhedral cells and stellate reticulum-like cells with various densities were spread over a wide range of the field. The lesion was curetted and after 2 years of follow up, it did not recur.

IDEF method for designing seismic information system in CTBT verification

International Nuclear Information System (INIS)

Zheng Xuefeng; Shen Junyi; Jin Ping; Zhang Huimin; Zheng Jiangling; Sun Peng

2004-01-01

Seismic information system is of great importance for improving the capability of CTBT verification. A large amount of money has been appropriated for the research in this field in the U.S. and some other countries in recent years. However, designing and developing a seismic information system involves various technologies about complex system design. This paper discusses the IDEF0 method to construct function models and the IDEF1x method to make information models systemically, as well as how they are used in designing seismic information system in CTBT verification. (authors)

Scenario-based design: a method for connecting information system design with public health operations and emergency management.

Science.gov (United States)

Reeder, Blaine; Turner, Anne M

2011-12-01

Responding to public health emergencies requires rapid and accurate assessment of workforce availability under adverse and changing circumstances. However, public health information systems to support resource management during both routine and emergency operations are currently lacking. We applied scenario-based design as an approach to engage public health practitioners in the creation and validation of an information design to support routine and emergency public health activities. Using semi-structured interviews we identified the information needs and activities of senior public health managers of a large municipal health department during routine and emergency operations. Interview analysis identified 25 information needs for public health operations management. The identified information needs were used in conjunction with scenario-based design to create 25 scenarios of use and a public health manager persona. Scenarios of use and persona were validated and modified based on follow-up surveys with study participants. Scenarios were used to test and gain feedback on a pilot information system. The method of scenario-based design was applied to represent the resource management needs of senior-level public health managers under routine and disaster settings. Scenario-based design can be a useful tool for engaging public health practitioners in the design process and to validate an information system design. Copyright © 2011 Elsevier Inc. All rights reserved.

Making Informed Decisions: The Role of Information Literacy in Ethical and Effective Engineering Design

Science.gov (United States)

Fosmire, Michael

2017-01-01

Engineering designers must make evidence-based decisions when applying the practical tools and techniques of their discipline to human problems. Information literacy provides a structure for determining information gaps, locating appropriate and relevant information, applying that information effectively, and documenting and managing the knowledge…

Beauty and cuteness in peripheral vision

Science.gov (United States)

Kuraguchi, Kana; Ashida, Hiroshi

2015-01-01

Guo et al. (2011) showed that attractiveness was detectable in peripheral vision. Since there are different types of attractiveness (Rhodes, 2006), we investigated how beauty and cuteness are detected in peripheral vision with a brief presentation. Participants (n = 45) observed two Japanese female faces for 100 ms, then were asked to respond which face was more beautiful (or cuter). The results indicated that both beauty and cuteness were detectable in peripheral vision, but not in the same manner. Discrimination rates for judging beauty were invariant in peripheral and central vision, while discrimination rates for judging cuteness declined in peripheral vision as compared with central vision. This was not explained by lower resolution in peripheral vision. In addition, for male participants, it was more difficult to judge cuteness than beauty in peripheral vision, thus suggesting that gender differences can have a certain effect when judging cuteness. Therefore, central vision might be suitable for judging cuteness while judging beauty might not be affected by either central or peripheral vision. This might be related with the functional difference between beauty and cuteness. PMID:25999883

INFORMATION DISPLAY: CONSIDERATIONS FOR DESIGNING COMPUTER-BASED DISPLAY SYSTEMS

International Nuclear Information System (INIS)

O'HARA, J.M.; PIRUS, D.; BELTRATCCHI, L.

2004-01-01

This paper discussed the presentation of information in computer-based control rooms. Issues associated with the typical displays currently in use are discussed. It is concluded that these displays should be augmented with new displays designed to better meet the information needs of plant personnel and to minimize the need for interface management tasks (the activities personnel have to do to access and organize the information they need). Several approaches to information design are discussed, specifically addressing: (1) monitoring, detection, and situation assessment; (2) routine task performance; and (3) teamwork, crew coordination, collaborative work

World Key Information Service System Designed For EPCOT Center

Science.gov (United States)

Kelsey, J. A.

1984-03-01

An advanced Bell Laboratories and Western Electric designed electronic information retrieval system utilizing the latest Information Age technologies, and a fiber optic transmission system is featured at the Walt Disney World Resort's newest theme park - The Experimental Prototype Community of Tomorrow (EPCOT Center). The project is an interactive audio, video and text information system that is deployed at key locations within the park. The touch sensitive terminals utilizing the ARIEL (Automatic Retrieval of Information Electronically) System is interconnected by a Western Electric designed and manufactured lightwave transmission system.

Chiral dynamics and peripheral transverse densities

Energy Technology Data Exchange (ETDEWEB)

Granados, Carlos G. [Uppsala University (Sweden); Weiss, Christian [JLAB, Newport News, VA (United States)

2014-01-01

In the partonic (or light-front) description of relativistic systems the electromagnetic form factors are expressed in terms of frame-independent charge and magnetization densities in transverse space. This formulation allows one to identify the chiral components of nucleon structure as the peripheral densities at transverse distances b = O(M{sub {pi}}{sup -1}) and compute them in a parametrically controlled manner. A dispersion relation connects the large-distance behavior of the transverse charge and magnetization densities to the spectral functions of the Dirac and Pauli form factors near the two--pion threshold at timelike t = 4 M{ sub {pi}}{sup 2}, which can be computed in relativistic chiral effective field theory. Using the leading-order approximation we (a) derive the asymptotic behavior (Yukawa tail) of the isovector transverse densities in the "chiral" region b = O(M{sub {pi}}{sup -1}) and the "molecular" region b = O(M{sub N}{sup 2}/M{sub {pi}}{sup 3}); (b) perform the heavy-baryon expansion of the transverse densities; (c) explain the relative magnitude of the peripheral charge and magnetization densities in a simple mechanical picture; (d) include Delta isobar intermediate states and study the peripheral transverse densities in the large-N{ sub c} limit of QCD; (e) quantify the region of transverse distances where the chiral components of the densities are numerically dominant; (f) calculate the chiral divergences of the b{sup 2}-weighted moments of the isovector transverse densities (charge and anomalous magnetic radii) in the limit M{sub {pi}} -> 0 and determine their spatial support. Our approach provides a concise formulation of the spatial structure of the nucleon's chiral component and offers new insights into basic properties of the chiral expansion. It relates the information extracted from low-t elastic form factors to the generalized parton distributions probed in peripheral high-energy scattering processes.

Guidelines for preparing IAEA design information questionnaires

International Nuclear Information System (INIS)

Swartz, J.M.; Bieber, A.M.

1980-01-01

The format of the IAEA Design Information Questionnaires and the SAI prepared guidelines for completing them, is described. The guidelines should assist facility operators in meeting the time constraints set forth in the Subsidiary Arrangements by effectively supplying the information needed by the IAEA and in minimizing resource allocations to the preparation effort. 8 refs

Hepatic abscess versus peripheral cholangiocarcinoma: Sonographic differentiation

Energy Technology Data Exchange (ETDEWEB)

Chung, Hwan Hoon; Kim, Yun Hwan; Kang, Chang Ho; Chung, Kyoo Byung; Suh, Won Hyuck [Korea University College of Medicine, Seoul (Korea, Republic of); Lee, Chang Hee [Kunkuk University College of Medicine, Chung-Ju Hospital, Chung-Ju (Korea, Republic of)

2000-12-15

To find out the sonographic findings that are useful to differentiate hepatic abscess from peripheral cholangiocarcinoma. Twenty-two hepatic abscesses and 22 peripheral cholangiocarcinomas which had been confirmed histologically were included in this study. Objective points were echo characteristics of the lesion, internal septation, presence of peripheral low echoic rim, demarcation from normal liver(well or poorly defined), posterior enhancement, multiplicity, dilatation of bile duct(obstructive or non-obstructive), intrahepatic duct stone, pleural effusion, and intra-abdominal fluid collection. Echo characteristics of the lesion were classified in-to four types. Type I; Predominantly echogenic with hypoechoic portion, type II; Echogenic without hypoechoic portion, type III; Predominantly hypoechoic with echogenic portion, type IV; Hypoechoic without echogenic portion. 1)Nine abscesses and 2 peripheral cholangiocarcinomas were type I(p=0.037), 2)One abscess and 18 peripheral cholangiocarcinomas were type II(p=0.001), 3)Seven abscesses and none of peripheral cholangiocarcinomas were type III(p=0.001), 4)Five abscesses and 2 peripheral cholangiocarcinomas were type IV(p=0.410). Only 7 abscesses showed internal septations(p=0.013). One abscess and 9 peripheral cholangiocarcinomas showed peripheral hypoechoic halos(p=0.012). Only 9 peripheral cholangiocarcinomas showed obstructive bile duct dilatation (p=0.001). There were no statistically significant differences between abscess and peripheral cholangiocarcinoma on other objective points. Predominantly echogenic with hypoechoic portion, predominantly hypoechoic with echogenic portion, and internal septation are the features suggestive of hepatic abscess, and echogenic without hypoechoic portion, peripheral hypoechoic halo, obstructive bile duct dilatation are suggestive of peripheral cholangiocarcinoma. Therefore these sonographic findings are helpful to differentiate hepatic abscess from peripheral

Integrated plant information technology design support functionality

International Nuclear Information System (INIS)

Kim, Yeon Seung; Kim, Dae Jin; Barber, P. W.; Goland, D.

1996-06-01

This technical report was written as a result of Integrated Plant Information System (IPIS) feasibility study on CANDU 9 project which had been carried out from January, 1994 to March, 1994 at AECL (Atomic Energy Canada Limited) in Canada. From 1987, AECL had done endeavour to change engineering work process from paper based work process to computer based work process through CANDU 3 project. Even though AECL had a lot of good results form computerizing the Process Engineering, Instrumentation Control and Electrical Engineering, Mechanical Engineering, Computer Aided Design and Drafting, and Document Management System, but there remains the problem of information isolation and integration. On this feasibility study, IPIS design support functionality guideline was suggested by evaluating current AECL CAE tools, analyzing computer aided engineering task and work flow, investigating request for implementing integrated computer aided engineering and describing Korean request for future CANDU design including CANDU 9. 6 figs. (Author)

Integrated plant information technology design support functionality

Energy Technology Data Exchange (ETDEWEB)

Kim, Yeon Seung; Kim, Dae Jin [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of); Barber, P W; Goland, D [Atomic Energy Canada Ltd., (Canada)

1996-06-01

This technical report was written as a result of Integrated Plant Information System (IPIS) feasibility study on CANDU 9 project which had been carried out from January, 1994 to March, 1994 at AECL (Atomic Energy Canada Limited) in Canada. From 1987, AECL had done endeavour to change engineering work process from paper based work process to computer based work process through CANDU 3 project. Even though AECL had a lot of good results form computerizing the Process Engineering, Instrumentation Control and Electrical Engineering, Mechanical Engineering, Computer Aided Design and Drafting, and Document Management System, but there remains the problem of information isolation and integration. On this feasibility study, IPIS design support functionality guideline was suggested by evaluating current AECL CAE tools, analyzing computer aided engineering task and work flow, investigating request for implementing integrated computer aided engineering and describing Korean request for future CANDU design including CANDU 9. 6 figs. (Author).

Organizational Information Requirements, Media Richness and Structural Design

OpenAIRE

Richard L. Daft; Robert H. Lengel

1986-01-01

This paper answers the question, "Why do organizations process information?" Uncertainty and equivocality are defined as two forces that influence information processing in organizations. Organization structure and internal systems determine both the amount and richness of information provided to managers. Models are proposed that show how organizations can be designed to meet the information needs of technology, interdepartmental relations, and the environment. One implication for managers i...

Design and Analysis: Payroll of Accounting Information System

OpenAIRE

Suryanto, Suryanto

2011-01-01

Purpose of the research are to analyze, design, and recommended the payroll of accounting information system that support the internal control to solve the problem. Research methods used are book studies, field studies, and design studies. Fields studies done by survey and interview. The expected result are to give a review about the payroll of accounting information system in the ongoing business process of company and to solve all the weakness in the payroll system, so the company can use t...

The Design Space of Information Presentation

DEFF Research Database (Denmark)

May, Michael; Petersen, Johannes

2007-01-01

A semiotic approach to the design space of information presentation is presented in which Formal Concept Analysis (FCA) is used to represent and explore attributes of abstract sign types and the media (graphical, haptic, acoustic, gestic) through which they are presented as specific...

Information Management in Creative Engineering Design and Capabilities of Database Transactions

DEFF Research Database (Denmark)

Jacobsen, Kim; Eastman, C. A.; Jeng, T. S.

1997-01-01

This paper examines the information management requirements and sets forth the general criteria for collaboration and concurrency control in creative engineering design. Our work attempts to recognize the full range of concurrency, collaboration and complex transactions structure now practiced...... in manual and semi-automated design and the range of capabilities needed as the demands for enhanced but flexible electronic information management unfolds.The objective of this paper is to identify new issues that may advance the use of databases to support creative engineering design. We start...... with a generalized description of the structure of design tasks and how information management in design is dealt with today. After this review, we identify extensions to current information management capabilities that have been realized and/or proposed to support/augment what designers can do now. Given...

Imaging findings and therapeutic alternatives for peripheral vascular malformations

International Nuclear Information System (INIS)

Monsignore, Lucas Moretti; Nakiri, Guilherme Seizem; Santos, Daniela dos; Abud, Thiago Giansante; Abud, Daniel Giansante

2010-01-01

Peripheral vascular malformations represent a spectrum of lesions that appear through the lifetime and can be found in the whole body. Such lesions are uncommon and are frequently confounded with infantile hemangioma, a common benign neoplastic lesion. In the presence of such lesions, the correlation between the clinical and radiological findings is extremely important to achieve a correct diagnosis, which will guide the best therapeutic approach. The most recent classifications for peripheral vascular malformations are based on the blood flow (low or high) and on the main vascular components (arterial, capillary, lymphatic or venous). Peripheral vascular malformations represent a diagnostic and therapeutic challenge, and complementary methods such as computed tomography, Doppler ultrasonography and magnetic resonance imaging, in association with clinical findings can provide information regarding blood flow characteristics and lesions extent. Arteriography and venography confirm the diagnosis, evaluate the lesions extent and guide the therapeutic decision making. Generally, low flow vascular malformations are percutaneously treated with sclerosing agents injection, while in high flow lesions the approach is endovascular, with permanent liquid or solid embolization agents. (author)

An information system supporting design for reliability and maintenance

International Nuclear Information System (INIS)

Rit, J.F.; Beraud, M.T.

1997-01-01

EDF is currently developing a methodology to integrate availability, operating experience and maintenance in the design of power plants. This involves studies that depend closely on the results and assumptions of each other about the reliability and operations of the plant. Therefore a support information system must be carefully designed. Concurrently with development of the methodology, a research oriented information system was designed and built. It is based on the database model of a logistic support repository that we tailored to our needs. (K.A.)

An information system supporting design for reliability and maintenance

Energy Technology Data Exchange (ETDEWEB)

Rit, J.F.; Beraud, M.T

1997-12-31

EDF is currently developing a methodology to integrate availability, operating experience and maintenance in the design of power plants. This involves studies that depend closely on the results and assumptions of each other about the reliability and operations of the plant. Therefore a support information system must be carefully designed. Concurrently with development of the methodology, a research oriented information system was designed and built. It is based on the database model of a logistic support repository that we tailored to our needs. (K.A.) 10 refs.

Peripheral visual performance enhancement by neurofeedback training.

Science.gov (United States)

Nan, Wenya; Wan, Feng; Lou, Chin Ian; Vai, Mang I; Rosa, Agostinho

2013-12-01

Peripheral visual performance is an important ability for everyone, and a positive inter-individual correlation is found between the peripheral visual performance and the alpha amplitude during the performance test. This study investigated the effect of alpha neurofeedback training on the peripheral visual performance. A neurofeedback group of 13 subjects finished 20 sessions of alpha enhancement feedback within 20 days. The peripheral visual performance was assessed by a new dynamic peripheral visual test on the first and last training day. The results revealed that the neurofeedback group showed significant enhancement of the peripheral visual performance as well as the relative alpha amplitude during the peripheral visual test. It was not the case in the non-neurofeedback control group, which performed the tests within the same time frame as the neurofeedback group but without any training sessions. These findings suggest that alpha neurofeedback training was effective in improving peripheral visual performance. To the best of our knowledge, this is the first study to show evidence for performance improvement in peripheral vision via alpha neurofeedback training.

CAMAC - an introduction into a system of standardized highways between computers and their peripherals

International Nuclear Information System (INIS)

Stuckenberg, H.J.

1975-10-01

CAMAC, which is a synonym for 'Computer Automated Measurement and Control', is a set of rules widely used in many countries for connecting processors and computers to the on-line peripherals. There are rules for an interface transferring the information via a common highway as well as for modular mechanical units in which the peripheral devices are housed together with the multipole connectors combining the computer with the controlled process. All peripherals in a system are sending the data and control information to the computer through parallel or serial highways which are defined also by the CAMAC rules. The use of CAMAC assures the possibility to combine compatible hardware of various suppliers in any system without mechanical or electrical difficulties making the hardware and software implementation much more easier. Also the reconfiguration of a system needed for new and other activities is done relatively fast and simple. Compatible devices are offered by about 60 suppliers in all five continents. (orig.) [de

The surgery of peripheral nerves (including tumors)

DEFF Research Database (Denmark)

Fugleholm, Kåre

2013-01-01

Surgical pathology of the peripheral nervous system includes traumatic injury, entrapment syndromes, and tumors. The recent significant advances in the understanding of the pathophysiology and cellular biology of peripheral nerve degeneration and regeneration has yet to be translated into improved...... surgical techniques and better outcome after peripheral nerve injury. Decision making in peripheral nerve surgery continues to be a complex challenge, where the mechanism of injury, repeated clinical evaluation, neuroradiological and neurophysiological examination, and detailed knowledge of the peripheral...... nervous system response to injury are prerequisite to obtain the best possible outcome. Surgery continues to be the primary treatment modality for peripheral nerve tumors and advances in adjuvant oncological treatment has improved outcome after malignant peripheral nerve tumors. The present chapter...

Management of engineering design information

International Nuclear Information System (INIS)

Gray, J.A.

1991-01-01

Westinghouse Idaho Nuclear Company, Inc. (WINCO) purchased a Design Management software package called SHERPA for use on the $1 billion Special Isotope Separation Project Sherpa is a customizable software shell that provides for the administrative management of the design function including production, approval, distribution and configuration control of project information. This project information can be either electronic or the traditional paper hardcopy. The use of this computerized system resulted in enhanced productivity and quality performance for the management, engineering, and administrative personnel on the project. The software currently runs on an HP9000 model 835 using the HP-UX operating system. The software had been completely customized to meet specific project needs. Existing databases were converted or left in tact to be accessed through the Sherpa software. Access to the system is available through IBM PCs. Dec terminals, Sun work stations, HP terminals, and X-windows terminals, in short most existing WINCO workstations. The software and hardware were delivered in February of 1990, and the system was on-line with all necessary data converted by the end of ApriL Through the use of the electronic approval function and the highly sophisticated query capabilities of the software, a cost savings of over 1500 personnel hours were realized during the closeout of the Project. The software has since been modified for use in the management of WINCO Environmental Compliance Information including Permits, NEPA, and RECRA documentation and records. Use of this software and hardware has resulted in an increase in quality and a large cost savings to WINCO

[Fuzzing pattern recognition study on Raman spectrum of tumor peripheral tissue].

Science.gov (United States)

Luo, Lei; Zhao, Yuan-li; Ge, Xiang-hong; Zhang, Xiao-dong; Hao, Zhi-fang; Lü, Jing

2006-06-01

On the basis of some theories about fuzzing pattern recognition, the present article studied the data preprocessing of the Raman spectrum of tumor peripheral tissue, and feature extraction and selection. According to these features the authors improved the leaning towards the bigger membership function of trapezoidal distribution. The authors built the membership function of Raman spectrum of tumor peripheral tissue which belongs to malignant tumor on the basis of 40 specimens, and designed the classifier. The test of other 40 specimens showed that the discrimination of malignant tumor is 82.4%, while that of beginning tumor is 73.9%.

Peripheral Circulatory Features during High-Frequency Jet Ventilation

Directory of Open Access Journals (Sweden)

M. B. Kontorovich

2010-01-01

Full Text Available The paper gives the results of a study of peripheral circulatory features during high-frequency jet ventilation (HFJV. The main specific features of peripheral circulation and oxygen transport during HFJV are formulated on the basis of a study of cardiac output (impedance cardiography, peripheral vascular resistance, peripheral vascular blood filling (photoplethysmogram analysis, adaptive peripheral blood flow reactions (spectral analysis of peripheral vascular pulsation. HFJV gives rise to the peculiar pattern of peripheral hemodynamics and tissue gas exchange, which is characterized by higher oxygen uptake without a decrease in mixed venous blood saturation, with normal extraction coefficient and preserved low peripheral vascular resistance. During HFJV, unlike traditional ventilation, the main peripheral hemodynamic feature is the increased capillary bed blood volume caused by the blood flow involvement of reserve capillaries under control of volume (parasympathetic regulation of adaptive peripheral hemodynamic reactions. Key words: high-frequency jet ventilation, oxygen transport, peripheral hemodynamics.

A Structured Review of Antithrombotic Therapy in Peripheral Artery Disease With a Focus on Revascularization: A TASC (InterSociety Consensus for the Management of Peripheral Artery Disease) Initiative.

Science.gov (United States)

Hess, Connie N; Norgren, Lars; Ansel, Gary M; Capell, Warren H; Fletcher, John P; Fowkes, F Gerry R; Gottsäter, Anders; Hitos, Kerry; Jaff, Michael R; Nordanstig, Joakim; Hiatt, William R

2017-06-20

Peripheral artery disease affects >200 million people worldwide and is associated with significant limb and cardiovascular morbidity and mortality. Limb revascularization is recommended to improve function and quality of life for symptomatic patients with peripheral artery disease with intermittent claudication who have not responded to medical treatment. For patients with critical limb ischemia, the goals of revascularization are to relieve pain, help wound healing, and prevent limb loss. The baseline risk of cardiovascular and limb-related events demonstrated among patients with stable peripheral artery disease is elevated after revascularization and related to atherothrombosis and restenosis. Both of these processes involve platelet activation and the coagulation cascade, forming the basis for the use of antiplatelet and anticoagulant therapies to optimize procedural success and reduce postprocedural cardiovascular risk. Unfortunately, few high-quality, randomized data to support use of these therapies after peripheral artery disease revascularization exist, and much of the rationale for the use of antiplatelet agents after endovascular peripheral revascularization is extrapolated from percutaneous coronary intervention literature. Consequently, guideline recommendations for antithrombotic therapy after lower limb revascularization are inconsistent and not always evidence-based. In this context, the purpose of this structured review is to assess the available randomized data for antithrombotic therapy after peripheral arterial revascularization, with a focus on clinical trial design issues that may affect interpretation of study results, and highlight areas that require further investigation. © 2017 American Heart Association, Inc.

Design and Analysis: Payroll of Accounting Information System

Directory of Open Access Journals (Sweden)

Suryanto Suryanto

2011-05-01

Full Text Available Purpose of the research are to analyze, design, and recommended the payroll of accounting information system that support the internal control to solve the problem. Research methods used are book studies, field studies, and design studies. Fields studies done by survey and interview. The expected result are to give a review about the payroll of accounting information system in the ongoing business process of company and to solve all the weakness in the payroll system, so the company can use the integrated information system in counting of the payroll. Conclusion that can take from the research are there’s some manipulation risk of attendance data and documentation of form still using a manual system and simple data backup. Then, there’s also manipulation risk in allowance cash system and all the report that include in the payroll.Index Terms - Accounting Information System, Payroll

THE IMPORTANCY OF THE INFORMATION SYSTEM TO DESIGN FIRMS’ MANAGEMENT

Directory of Open Access Journals (Sweden)

Flavia R SOUZA

2008-06-01

Full Text Available The design firms have fundamental responsibility and represent a fundamental link in the civil construction chain of production and the discussion about management of these firms, considering their limits and particular characteristics, aims promote actions to transform them effective organisations in this production environment. The information system is the component that connects all administrative process of a company, as the operational also the strategic. With regards it, this paper aims analysing and understanding the general information architecture of a design firm through the applying of method proposed by Turban; MacLean; Wetherbe (2004 called how “Information Requirement Analysis Planning Model “. Considering the paper authors experience about administrative and technical routines of these firms obtained through the research from 2006 to 2007, the model was applied at generic routines (administrative and technical of medium and small design firms. The research was supported by a bibliography revision about Information System subject and is part of a master degree dissertation of one the authors. Key-words: design firms, management, information system.

Product-oriented design theory for digital information services: A literature review.

NARCIS (Netherlands)

Wijnhoven, Alphonsus B.J.M.; Kraaijenbrink, Jeroen

2008-01-01

Purpose – The purpose of this paper is to give a structured literature review, design concepts, and research propositions related to a product-oriented design theory for information services. Information services facilitate the exchange of information goods with or without transforming these goods.

Information for the user in design of intelligent systems

Science.gov (United States)

Malin, Jane T.; Schreckenghost, Debra L.

1993-01-01

Recommendations are made for improving intelligent system reliability and usability based on the use of information requirements in system development. Information requirements define the task-relevant messages exchanged between the intelligent system and the user by means of the user interface medium. Thus, these requirements affect the design of both the intelligent system and its user interface. Many difficulties that users have in interacting with intelligent systems are caused by information problems. These information problems result from the following: (1) not providing the right information to support domain tasks; and (2) not recognizing that using an intelligent system introduces new user supervisory tasks that require new types of information. These problems are especially prevalent in intelligent systems used for real-time space operations, where data problems and unexpected situations are common. Information problems can be solved by deriving information requirements from a description of user tasks. Using information requirements embeds human-computer interaction design into intelligent system prototyping, resulting in intelligent systems that are more robust and easier to use.

Russian RBMK reactor design information

International Nuclear Information System (INIS)

1993-11-01

This document concerns the systems, design, and operations of the graphite-moderated, boiling, water-cooled, channel-type (RBMK) reactors located in the former Soviet Union (FSU). The Russian Academy of Sciences Nuclear Safety Institute (NSI) in Moscow, Russia, researched specific technical questions that were formulated by the Pacific Northwest Laboratory (PNL) and provided detailed technical answers to those questions. The Russian response was prepared in English by NSI in a question-and-answer format. This report presents the results of that technical exchange in the context they were received from the NSI organization. Pacific Northwest Laboratory is generating this document to support the US Department of Energy (DOE) community in responding to requests from FSU states, which are seeking Western technological and financial assistance to improve the safety systems of the Russian-designed reactors. This report expands upon information that was previously available to the United States through bilateral information exchanges, international nuclear society meetings, International Atomic Energy Agency (IAEA) reactor safety programs, and Research and Development Institute of Power Engineering (RDIPE) reports. The response to the PNL questions have not been edited or reviewed for technical consistency or accuracy by PNL staff or other US organizations, but are provided for use by the DOE community in the form they were received

Internet information triangulation: Design theory and prototype evaluation

NARCIS (Netherlands)

Wijnhoven, Alphonsus B.J.M.; Brinkhuis, Michel

2014-01-01

Many discussions exist regarding the credibility of information on the Internet. Similar discussions happen on the interpretation of social scientific research data, for which information triangulation has been proposed as a useful method. In this article, we explore a design theory—consisting of a

Activation of peripheral leukocytes in rat pregnancy and experimental preeclampsia

NARCIS (Netherlands)

Faas, MM; Schuiling, GA; Linton, EA; Sargent, IL; Redman, CWG

OBJECTIVE: The aim of this study was to search for activation markers of peripheral leukocytes in experimental preeclampsia in the rat. STUDY DESIGN: Experimental preeclampsia was induced in 14-day-pregnant rats by infusion of endotoxin (1.0 mu g/kg body weight). For comparison, rats with normal

GIS Application System Design Applied to Information Monitoring

Science.gov (United States)

Qun, Zhou; Yujin, Yuan; Yuena, Kang

Natural environment information management system involves on-line instrument monitoring, data communications, database establishment, information management software development and so on. Its core lies in collecting effective and reliable environmental information, increasing utilization rate and sharing degree of environment information by advanced information technology, and maximizingly providing timely and scientific foundation for environmental monitoring and management. This thesis adopts C# plug-in application development and uses a set of complete embedded GIS component libraries and tools libraries provided by GIS Engine to finish the core of plug-in GIS application framework, namely, the design and implementation of framework host program and each functional plug-in, as well as the design and implementation of plug-in GIS application framework platform. This thesis adopts the advantages of development technique of dynamic plug-in loading configuration, quickly establishes GIS application by visualized component collaborative modeling and realizes GIS application integration. The developed platform is applicable to any application integration related to GIS application (ESRI platform) and can be as basis development platform of GIS application development.

Data Requirements and the Basis for Designing Health Information Kiosks.

Science.gov (United States)

Afzali, Mina; Ahmadi, Maryam; Mahmoudvand, Zahra

2017-09-01

Health kiosks are an innovative and cost-effective solution that organizations can easily implement to help educate people. To determine the data requirements and basis for designing health information kiosks as a new technology to maintain the health of society. By reviewing the literature, a list of information requirements was provided in 4 sections (demographic information, general information, diagnostic information and medical history), and questions related to the objectives, data elements, stakeholders, requirements, infrastructures and the applications of health information kiosks were provided. In order to determine the content validity of the designed set, the opinions of 2 physicians and 2 specialists in medical informatics were obtained. The test-retest method was used to measure its reliability. Data were analyzed using SPSS software. In the proposed model for Iran, 170 data elements in 6 sections were presented for experts' opinion, which ultimately, on 106 elements, a collective agreement was reached. To provide a model of health information kiosk, creating a standard data set is a critical point. According to a survey conducted on the various literature review studies related to the health information kiosk, the most important components of a health information kiosk include six categories; information needs, data elements, applications, stakeholders, requirements and infrastructure of health information kiosks that need to be considered when designing a health information kiosk.

Peripherally applied opioids for postoperative pain

DEFF Research Database (Denmark)

Nielsen, B N; Henneberg, S W; Schmiegelow, K

2015-01-01

BACKGROUND: Opioids applied peripherally at the site of surgery may produce postoperative analgesia with few side effects. We performed this systematic review to evaluate the analgesic effect of peripherally applied opioids for acute postoperative pain. METHODS: We searched PubMed (1966 to June...... 2013), Embase (1980 to June 2013), and the Cochrane Central Register of Controlled Trials (The Cochrane Library 2013, Issue 6). Randomized controlled trials investigating the postoperative analgesic effect of peripherally applied opioids vs. systemic opioids or placebo, measured by pain intensity...... difference -5 mm, 95% CI: -7 to -3) for peripherally applied opioids vs. placebo and statistically significant increased time to first analgesic (mean difference 153 min, 95% CI: 41-265). When preoperative inflammation was reported (five studies), peripherally applied opioids significantly improved...

Peripheral doses in modulated intensive radiotherapy (MIRT) and its implications in radiological protection

International Nuclear Information System (INIS)

Cobos, Agustin C.; Sanz, Dario E.; Alvarez, Guilhermo D.

2013-01-01

A calculation model based on the theory of photon transport, to estimate the peripheral energy fluence (fluence occurring outside the radiation beam) produced by the dispersions of photon compensating filters used was developed in IMRT mode, in a treatment room radiotherapy service of FUESMEN. In order to validate the model were experimentally determined fluences and peripheral dose for three different sizes of compensating filters. It was found that there is a slight systematic overestimation model with respect to experimental results. The experimental values also allowed the comparison of the peripheral doses with other modalities. Furthermore, a model was developed to estimate the annual dose that occurs at any point to be protected with a shield, from the theoretical values obtained from peripheral energy flow. Using the theoretical values automatically allowed to take a conservative approach because of the slight overestimation already mentioned, the couple have a calculation model for widespread use. It was found that the contribution of the peripheral dose to the annual dose is more than significant, thus suggesting that the same should be considered in the design calculations of secondary barriers

Involuntary attention with uncertainty: peripheral cues improve perception of masked letters, but may impair perception of low-contrast letters.

Science.gov (United States)

Kerzel, Dirk; Gauch, Angélique; Buetti, Simona

2010-10-01

Improvements of perceptual performance following the presentation of peripheral cues have been ascribed to accelerated accrual of information, enhanced contrast perception, and decision bias. We investigated effects of peripheral cues on the perception of Gabor and letter stimuli. Non-predictive, peripheral cues improved perceptual accuracy when the stimuli were masked. In contrast, peripheral cues degraded perception of low-contrast letters and did not affect the perception of low-contrast Gabors. The results suggest that involuntary attention accelerates accrual of information but are not entirely consistent with the idea that involuntary attention enhances subjective contrast. Rather, peripheral cues may cause crowding with single letter targets of low contrast. Further, we investigated the effect of the amount of uncertainty on involuntary attention. Cueing effects were (initially) larger when there were more possible target locations. In addition, cueing effects were larger when error feedback was absent and observers had no knowledge of results. Despite these strategic factors, location uncertainty was not sufficient to produce cueing effects, showing that location uncertainty paired with non-predictive cues reveals perceptual and not (only) decisional processes.

Design Strategy of Information Construction Based on User Participation

Directory of Open Access Journals (Sweden)

Gao Jundong

2017-01-01

Full Text Available In the design of the Internet products, the information construction is one of the important factors to determine that whether a product is friendly. It is a challenge for every information architect to discover new innovations on the basis of established user habits. In practice, we often found that the development of many new functions did not meet the needs of users and many functions would be improved by users themselves, the fact of which shows the strong desire of users to participate in the development of products. Therefore, this article proposes an information architecture method based on the “users’ partially involved”, that is, when the main framework of a product is determined and the detailed architecture of part of the functions is proposed by users themselves, builders will help users to dig and organize their requirements and eventually integrate them into the design of architecture. In order to verify the effectiveness of this method, the article takes the virtual products for social service based on "surrounding geographic information" as an example. A comparison experiment was conducted on the effectiveness of the design of user-participant information architecture, and the experimental results were evaluated.

Information management for nuclear power stations: System Design Concept

International Nuclear Information System (INIS)

Halpin, D.W.

1978-03-01

A study of the information management structure required to support nuclear power plant construction was performed by a joint university-industry group under the sponsorship of the Department of Energy (DOE), formerly the Energy Research and Development Administration (ERDA). The purpose of this study was (1) to study methods for the control of information during the construction and start-up of nuclear power plants, and (2) identify those data elements intrinsic to nuclear power plants which must be maintained in a structured format for quick access and retrieval. Maintenance of the massive amount of data needed for control of a nuclear project during design, procurement, construction, start-up/testing, and operational phases requires a structuring which allows immediate update and retrieval based on a wide variety of access criteria. The objective of the research described has been to identify design concepts which support the development of an information control system responsive to these requirements. A conceptual design of a Management Information Data Base System which can meet the project control and information exchange needs of today's large nuclear power plant construction projects has been completed and an approach recommended for development and implementation of a complete operational system

OPTIMIZING THE DESIGN OF THE SYSTEMS OF INFORMATION PROTECTION IN AUTOMATED INFORMATIONAL SYSTEMS OF INDUSTRIAL ENTERPRISES

Directory of Open Access Journals (Sweden)

I. E. L'vovich

2014-01-01

Full Text Available Summary. Now to increase of indicators of efficiency and operability of difficult systems apply an automation equipment. The increasing role of information which became universal goods for relationship between various structures is noted. The question of its protection becomes the most actual. Special value is allocated for optimum design at creation of systems of the protection, allowing with the greatest probability to choose the best decisions on a set of alternatives. Now it becomes actual for the majority of the industrial enterprises as correctly designed and introduced system of protection will be pledge of successful functioning and competitiveness of all organization. Stages of works on creation of an information security system of the industrial enterprise are presented. The attention is focused on one of the most important approaches to realization of optimum design – multialternative optimization. In article the structure of creation of system of protection from the point of view of various models is considered, each of which gives an idea of features of design of system as a whole. The special attention is paid to a problem of creation of an information security system as it has the most difficult structure. Tasks for processes of automation of each of design stages of system of information security of the industrial enterprises are designated. Idea of each of stages of works is given at design of system of protection that allows to understand in the best way internal structure of creation of system of protection. Therefore, it is given the chance of evident submission of necessary requirements to creation of a reliable complex of information security of the industrial enterprise. Thereby it is given the chance of leveling of risks at early design stages of systems of protection, the organization and definition of necessary types of hardware-software complexes for future system.

The McKenzie method compared with manipulation when used adjunctive to information and advice in low back pain patients presenting with centralization or peripheralization. A randomized controlled trial

DEFF Research Database (Denmark)

Petersen, Tom; Larsen, Kristian; Nordsteen, Jan

2011-01-01

.Methods. A total of 350 patients suffering from low back pain with a duration of more than 6 weeks who presented with centralization or peripheralization of symptoms with or without signs of nerve root involvement, were enrolled in the trial. Main outcome was number of patients with treatment success defined...... a structured exercise programme tailored to the individual patient as well as manual therapy for the treatment of persistent low back pain. There is presently insufficient evidence to recommend the use of specific decision methods tailoring specific therapies to clinical subgroups of patients in primary care...... for more than six weeks presenting with centralization or peripheralization of symptoms, we found the McKenzie method to be slightly more effective than manipulation when used adjunctive to information and advice....

Designing digital health information in a health literacy context

NARCIS (Netherlands)

Meppelink, C.S.

2016-01-01

Digital health information is widely available, but not everyone fully benefits due to limited health literacy. Until now, little was known about how health literacy influences information processing and how design features of digital health information can be used to create optimal health messages

A design methodology for materials control and accounting information systems

International Nuclear Information System (INIS)

Helman, P.; Strittmatter, R.B.

1987-01-01

Modern approaches to nuclear materials safeguards have significantly increased the data processing needs of safeguards information systems. Implementing these approaches will require developing efficient, cost-effective designs. Guided by database design research, we are developing a design methodology for distributed materials control and accounting (MCandA) information systems. The methodology considers four design parameters: network topology, allocation of data to nodes, high-level global processing strategy, and local file structures to optimize system performance. Characteristics of system performance that are optimized are response time for an operation, timeliness of data, validity of data, and reliability. The ultimate goal of the research is to develop a comprehensive computerized design tool specifically tailored to the design of MCandA systems

Neurophysiological approach to disorders of peripheral nerve

DEFF Research Database (Denmark)

Crone, Clarissa; Krarup, Christian

2013-01-01

Disorders of the peripheral nerve system (PNS) are heterogeneous and may involve motor fibers, sensory fibers, small myelinated and unmyelinated fibers and autonomic nerve fibers, with variable anatomical distribution (single nerves, several different nerves, symmetrical affection of all nerves......, plexus, or root lesions). Furthermore pathological processes may result in either demyelination, axonal degeneration or both. In order to reach an exact diagnosis of any neuropathy electrophysiological studies are crucial to obtain information about these variables. Conventional electrophysiological...

Silicone Molding and Lifetime Testing of Peripheral Nerve Interfaces for Neuroprostheses

Energy Technology Data Exchange (ETDEWEB)

Gupte, Kimaya [Case Western Reserve Univ., Cleveland, OH (United States). Dept. of Biomedical Engineering; Tolosa, Vanessa [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Center for Micro- and Nanotechnology

2016-08-10

Implantable peripheral nerve cuffs have a large application in neuroprostheses as they can be used to restore sensation to those with upper limb amputations. Modern day prosthetics, while lessening the pain associated with phantom limb syndrome, have limited fine motor control and do not provide sensory feedback to patients. Sensory feedback with prosthetics requires communication between the nervous system and limbs, and is still a challenge to accomplish with amputees. Establishing this communication between the peripheral nerves in the arm and artificial limbs is vital as prosthetics research aims to provide sensory feedback to amputees. Peripheral nerve cuffs restore sensation by electrically stimulating certain parts of the nerve in order to create feeling in the hand. Cuff electrodes have an advantage over standard electrodes as they have high selective stimulation by bringing the electrical interface close to the neural tissue in order to selectively activate targeted regions of a peripheral nerve. In order to further improve the selective stimulation of these nerve cuffs, there is need for finer spatial resolution among electrodes. One method to achieve a higher spatial resolution is to increase the electrode density on the cuff itself. Microfabrication techniques can be used to achieve this higher electrode density. Using L-Edit, a layout editor, microfabricated peripheral nerve cuffs were designed with a higher electrode density than the current model. This increase in electrode density translates to an increase in spatial resolution by at least one order of magnitude. Microfabricated devices also have two separate components that are necessary to understand before implantation: lifetime of the device and assembly to prevent nerve damage. Silicone molding procedures were optimized so that devices do not damage nerves in vivo, and lifetime testing was performed on test microfabricated devices to determine their lifetime in vivo. Future work of this project

Burn-related peripheral neuropathy: A systematic review.

Science.gov (United States)

Tu, Yiji; Lineaweaver, William C; Zheng, Xianyou; Chen, Zenggan; Mullins, Fred; Zhang, Feng

2017-06-01

Peripheral neuropathy is the most frequent disabling neuromuscular complication of burns. However, the insidious and progressive onset of burn neuropathy makes it often undiagnosed or overlooked. In our study, we reviewed the current studies on the burn-related peripheral neuropathy to summarize the morbidity, mechanism, detecting method and management of peripheral neuropathy in burn patients. Of the 1533 burn patients included in our study, 98 cases (6.39%) were presented with peripheral neuropathy. Thermal and electrical burns were the most common etiologies. Surgical procedures, especially nerve decompression, showed good effect on functional recovery of both acute and delayed peripheral neuropathy in burn patients. It is noteworthy that, for early detection and prevention of peripheral neuropathy, electrodiagnostic examinations should be performed on burn patients independent of symptoms. Still, the underlying mechanisms of burn-related peripheral neuropathy remain to be clarified. Copyright © 2016 Elsevier Ltd and ISBI. All rights reserved.

Considering value of information when using CFD in design

Energy Technology Data Exchange (ETDEWEB)

Misra, John Satprim [Iowa State Univ., Ames, IA (United States)

2009-01-01

This thesis presents an approach to find lower resolution CFD models that can accurately lead a designer to a correct decision at a lower computational cost. High-fidelity CFD models often contain too much information and come at a higher computational cost, limiting the designs a designer can test and how much optimization can be performed on the design. Lower model resolution is commonly used to reduce computational time. However there are no clear guidelines on how much model accuracy is required. Instead experience and intuition are used to select an appropriate lower resolution model. This thesis presents an alternative to this ad hoc method by considering the added value of the addition information provided by increasing accurate and more computationally expensive models.

Conformally integrated stent cell resonators for wireless monitoring of peripheral artery disease

KAUST Repository

Viswanath, Anupam; Green, Scott Ryan; Kosel, Jü rgen; Gianchandani, Yogesh B.

2013-01-01

This paper presents the design and in vitro evaluation of magnetoelastic sensors intended for wireless monitoring of tissue accumulation in peripheral artery stents. The sensors, shaped like stent cells, are fabricated from 28-μm thick foils

Information Architecture without Internal Theory: An Inductive Design Process.

Science.gov (United States)

Haverty, Marsha

2002-01-01

Suggests that information architecture design is primarily an inductive process, partly because it lacks internal theory and partly because it is an activity that supports emergent phenomena (user experiences) from basic design components. Suggests a resemblance to Constructive Induction, a design process that locates the best representational…

Assessment Tools for Peripheral Neuropathy in Pediatric Oncology: A Systematic Review From the Children's Oncology Group.

Science.gov (United States)

Smolik, Suzanne; Arland, Lesley; Hensley, Mary Ann; Schissel, Debra; Shepperd, Barbara; Thomas, Kristin; Rodgers, Cheryl

Peripheral neuropathy is a known side effect of several chemotherapy agents, including vinca alkaloids and platinum-based chemotherapy. Early recognition and monitoring of this side effect is an important role of the pediatric oncology nurse. There are a variety of peripheral neuropathy assessment tools currently in use, but the usefulness of these tools in identifying and grading neuropathy in children varies, and there is currently no standardized tool in place to evaluate peripheral neuropathy in pediatric oncology. A systematic review was performed to identify the peripheral neuropathy assessment tools that best evaluate the early onset and progression of peripheral neuropathy in pediatric patients receiving vincristine. Because of the limited information available in pediatric oncology, this review was extended to any pediatric patient with neuropathy. A total of 8 studies were included in the evidence synthesis. Based on available evidence, the pediatric-modified Total Neuropathy Scale (ped-m TNS) and the Total Neuropathy Score-pediatric version (TNS-PV) are recommended for the assessment of vincristine-induced peripheral neuropathy in children 6 years of age and older. In addition, several studies demonstrated that subjective symptoms alone are not adequate to assess for vincristine-induced peripheral neuropathy. Nursing assessment of peripheral neuropathy should be an integral and regular part of patient care throughout the course of chemotherapy treatment.

An information model to support user-centered design of medical devices.

Science.gov (United States)

Hagedorn, Thomas J; Krishnamurty, Sundar; Grosse, Ian R

2016-08-01

The process of engineering design requires the product development team to balance the needs and limitations of many stakeholders, including those of the user, regulatory organizations, and the designing institution. This is particularly true in medical device design, where additional consideration must be given for a much more complex user-base that can only be accessed on a limited basis. Given this inherent challenge, few projects exist that consider design domain concepts, such as aspects of a detailed design, a detailed view of various stakeholders and their capabilities, along with the user-needs simultaneously. In this paper, we present a novel information model approach that combines a detailed model of design elements with a model of the design itself, customer requirements, and of the capabilities of the customer themselves. The information model is used to facilitate knowledge capture and automated reasoning across domains with a minimal set of rules by adopting a terminology that treats customer and design specific factors identically, thus enabling straightforward assessments. A uniqueness of this approach is that it systematically provides an integrated perspective on the key usability information that drive design decisions towards more universal or effective outcomes with the very design information impacted by the usability information. This can lead to cost-efficient optimal designs based on a direct inclusion of the needs of customers alongside those of business, marketing, and engineering requirements. Two case studies are presented to show the method's potential as a more effective knowledge management tool with built-in automated inferences that provide design insight, as well as its overall effectiveness as a platform to develop and execute medical device design from a holistic perspective. Copyright © 2016 Elsevier Inc. All rights reserved.

DESIGN INFORMATION VERIFICATION FOR NUCLEAR SAFEGUARDS

Energy Technology Data Exchange (ETDEWEB)

Robert S. Bean; Richard R. M. Metcalf; Phillip C. Durst

2009-07-01

A critical aspect of international safeguards activities performed by the International Atomic Energy Agency (IAEA) is the verification that facility design and construction (including upgrades and modifications) do not create opportunities for nuclear proliferation. These Design Information Verification activities require that IAEA inspectors compare current and past information about the facility to verify the operator’s declaration of proper use. The actual practice of DIV presents challenges to the inspectors due to the large amount of data generated, concerns about sensitive or proprietary data, the overall complexity of the facility, and the effort required to extract just the safeguards relevant information. Planned and anticipated facilities will (especially in the case of reprocessing plants) be ever larger and increasingly complex, thus exacerbating the challenges. This paper reports the results of a workshop held at the Idaho National Laboratory in March 2009, which considered technologies and methods to address these challenges. The use of 3D Laser Range Finding, Outdoor Visualization System, Gamma-LIDAR, and virtual facility modeling, as well as methods to handle the facility data issues (quantity, sensitivity, and accessibility and portability for the inspector) were presented. The workshop attendees drew conclusions about the use of these techniques with respect to successfully employing them in an operating environment, using a Fuel Conditioning Facility walk-through as a baseline for discussion.

Informational literacy in higher education: design of a mensuration tool

Directory of Open Access Journals (Sweden)

María del Carmen Toledo Sánchez

2015-11-01

Full Text Available Objective. To show psychometric research phase to examine the validity of an instrument designed to measure information literacy in the Institutions of higher education in Mexico. Method. The questionnaire design of 50 items was based on the UNESCO standards of information and communication technologies (ICT competencies for teachers and skills standards for access and use of information in higher education. The methodological strategy contemplated verification of content validity, item-item correlation and construct through factorial analysis. The sample was 73 professors and librarians who work in educational institutions of northwestern Mexico. Results. The final design was reduced to 44 items, and it demonstrated the items evaluate the same construct in their internal structure, and revealed 5 dimensions for informational variable competencies and 5 competencies for ICT. Conclusions. The items have good clarity regarding the specific concept, nevertheless, the elimination of 6 items was needed proving to be a valid and reliable instrument to measure the informational literacy in the studied context.

Ultrasonographic evaluation of the iatrogenic peripheral nerve injuries in upper extremity

International Nuclear Information System (INIS)

Karabay, Nuri; Toros, Tulgar; Ademoglu, Yalcin; Ada, Sait

2010-01-01

The aim of our study is to assess the efficiency of the ultrasonography (US) in the diagnosis of peripheral nerve injury. This study includes nine patients (six radial, one median and two posterior interosseous (PIO) nerves) with peripheral nerve injury diagnosed by clinical and electrophysiological methods in the last 3 years. Preoperatively, an ultrasonographic examination was performed and correlated with physical exam and surgical findings. Five patients, who were diagnosed as peripheral nerve transection by US, underwent surgery. The ultrasonographic findings were concordant with the intraoperative findings. Axonal swelling alone was found in the remaining three patients, who were treated conservatively because of preserved nerve continuity without display of nerve compression. In one patient, we were unable to visualize the nerve due to obesity and soft tissue edema. High-resolution US provide morphological information about the exact location, intensity and extent of the nerve injuries, facilitating the preoperative diagnosis. Thus, US may be a useful method for planning optimal treatment strategy in especially iatrogenic nerve injuries.

Ultrasonographic evaluation of the iatrogenic peripheral nerve injuries in upper extremity

Energy Technology Data Exchange (ETDEWEB)

Karabay, Nuri [Department of Radiology, Hand and Microsurgery and Orthopaedics and Traumatology (EMOT) Hospital, 1418 Sok. No: 14 Kahramanlar, 35230 Izmir (Turkey)], E-mail: nurikarabay@gmail.com; Toros, Tulgar [Department of Orthopaedics and Traumatology, Hand and Microsurgery and Orthopaedics and Traumatology (EMOT) Hospital, 1418 Sok. No: 14 Kahramanlar, 35230 Izmir (Turkey)], E-mail: tulgartoros@yahoo.com; Ademoglu, Yalcin [Department of Orthopaedics and Traumatology, Hand and Microsurgery and Orthopaedics and Traumatology (EMOT) Hospital, 1418 Sok. No: 14 Kahramanlar, 35230 Izmir (Turkey)], E-mail: yalcinademoglu@yahoo.com; Ada, Sait [Department of Orthopaedics and Traumatology, Hand and Microsurgery and Orthopaedics and Traumatology (EMOT) Hospital, 1418 Sok. No: 14 Kahramanlar, 35230 Izmir (Turkey)], E-mail: sait_ada@yahoo.com

2010-02-15

The aim of our study is to assess the efficiency of the ultrasonography (US) in the diagnosis of peripheral nerve injury. This study includes nine patients (six radial, one median and two posterior interosseous (PIO) nerves) with peripheral nerve injury diagnosed by clinical and electrophysiological methods in the last 3 years. Preoperatively, an ultrasonographic examination was performed and correlated with physical exam and surgical findings. Five patients, who were diagnosed as peripheral nerve transection by US, underwent surgery. The ultrasonographic findings were concordant with the intraoperative findings. Axonal swelling alone was found in the remaining three patients, who were treated conservatively because of preserved nerve continuity without display of nerve compression. In one patient, we were unable to visualize the nerve due to obesity and soft tissue edema. High-resolution US provide morphological information about the exact location, intensity and extent of the nerve injuries, facilitating the preoperative diagnosis. Thus, US may be a useful method for planning optimal treatment strategy in especially iatrogenic nerve injuries.

Intraoperative Ultrasound for Peripheral Nerve Applications.

Science.gov (United States)

Willsey, Matthew; Wilson, Thomas J; Henning, Phillip Troy; Yang, Lynda J-S

2017-10-01

Offering real-time, high-resolution images via intraoperative ultrasound is advantageous for a variety of peripheral nerve applications. To highlight the advantages of ultrasound, its extraoperative uses are reviewed. The current intraoperative uses, including nerve localization, real-time evaluation of peripheral nerve tumors, and implantation of leads for peripheral nerve stimulation, are reviewed. Although intraoperative peripheral nerve localization has been performed previously using guide wires and surgical dyes, the authors' approach using ultrasound-guided instrument clamps helps guide surgical dissection to the target nerve, which could lead to more timely operations and shorter incisions. Copyright © 2017 Elsevier Inc. All rights reserved.

Design Principles for the Information Architecture of a SMET Education Digital Library.

Science.gov (United States)

Dong, Andy; Agogino, Alice M.

This implementation paper introduces principles for the information architecture of an educational digital library, principles that address the distinction between designing digital libraries for education and designing digital libraries for information retrieval in general. Design is a key element of any successful product. Good designers and…

Guiding Device for Precision Grafting of Peripheral Nerves in Complete Thoracic Spinal Cord Injury: Design and Sizing for Clinical Trial

Directory of Open Access Journals (Sweden)

Arvid Frostell

2018-05-01

Full Text Available BackgroundIn an effort to translate preclinical success in achieving spinal cord regeneration through peripheral nerve grafts, this study details the design and sizing of a guiding device for precision grafting of peripheral nerves for use in a clinical trial in complete (AIS-A thoracic spinal cord injury (SCI. The device’s design and sizing are compared to a simulation of human spinal cord sizes based on the best available data.MethodsSpinal cord segmental sizes were generated by computer simulation based on data from a meta-analysis recently published by our group. Thoracic segments T2–T12 were plotted, and seven elliptical shapes were positioned across the center of the distribution of sizes. Geometrical measures of error-of-fit were calculated. CAD modeling was used to create cranial and caudal interfaces for the human spinal cord, aiming to guide descending white matter tracts to gray matter at the caudal end of the device and ascending white matter tracts to gray matter at the cranial end of the device. The interfaces were compared qualitatively to the simulated spinal cord sizes and gray-to-white matter delineations.ResultsThe mean error-of-fit comparing simulated spinal cord segments T2–T12 to the best elliptical shape was 0.41 and 0.36 mm, and the 95th percentile was found at 1.3 and 0.98 mm for transverse and anteroposterior diameter, respectively. A guiding device design was reached for capturing the majority of corticospinal axons at the cranial end of the device and guiding them obliquely to gray matter at the caudal end of the device. Based on qualitative comparison, the vast majority of spinal cord sizes generated indicate an excellent fit to the device’s interfaces.ConclusionA set of SCI guiding devices of seven sizes can cover the variability of human thoracic spinal cord segments T2–T12 with an acceptable error-of-fit for the elliptical shape as well as guiding channels. The computational framework developed can

Functional deficits in peripheral nerve mitochondria in rats with paclitaxel- and oxaliplatin-evoked painful peripheral neuropathy

OpenAIRE

Zheng, Huaien; Xiao, Wen Hua; Bennett, Gary J.

2011-01-01

Cancer chemotherapeutics like paclitaxel and oxaliplatin produce a dose-limiting chronic sensory peripheral neuropathy that is often accompanied by neuropathic pain. The cause of the neuropathy and pain is unknown. In animal models, paclitaxel-evoked and oxaliplatin-evoked painful peripheral neuropathies are accompanied by an increase in the incidence of swollen and vacuolated mitochondria in peripheral nerve axons. It has been proposed that mitochondrial swelling and vacuolation are indicati...

Improving the analysis of designed studies by combining statistical modelling with study design information

NARCIS (Netherlands)

Thissen, U.; Wopereis, S.; Berg, S.A.A. van den; Bobeldijk, I.; Kleemann, R.; Kooistra, T.; Dijk, K.W. van; Ommen, B. van; Smilde, A.K.

2009-01-01

Background: In the fields of life sciences, so-called designed studies are used for studying complex biological systems. The data derived from these studies comply with a study design aimed at generating relevant information while diminishing unwanted variation (noise). Knowledge about the study

Understanding teachers’ routines to inform classroom technology design

NARCIS (Netherlands)

An, P.; Bakker, S.; Eggen, J.H.

2017-01-01

Secondary school teachers have quite busy and complex routines in their classrooms. However, present classroom technologies usually require focused attention from teachers while being interacted with, which restricts their use in teachers’ daily routines. Peripheral interaction is a human-computer

OPERATIONS RESEARCH IN THE DESIGN OF MANAGEMENT INFORMATION SYSTEMS

Science.gov (United States)

management information systems is concerned with the identification and detailed specification of the information and data processing...of advanced data processing techniques in management information systems today, the close coordination of operations research and data systems activities has become a practical necessity for the modern business firm.... information systems in which mathematical models are employed as the basis for analysis and systems design. Operations research provides a

Evidence-Based Design and Research-Informed Design: What's the Difference? Conceptual Definitions and Comparative Analysis.

Science.gov (United States)

Peavey, Erin; Vander Wyst, Kiley B

2017-10-01

This article provides critical examination and comparison of the conceptual meaning and underlying assumptions of the concepts evidence-based design (EBD) and research-informed design (RID) in order to facilitate practical use and theoretical development. In recent years, EBD has experienced broad adoption, yet it has been simultaneously critiqued for rigidity and misapplication. Many practitioners are gravitating to the term RID to describe their method of integrating knowledge into the design process. However, the term RID lacks a clear definition and the blurring of terms has the potential to weaken advances made integrating research into practice. Concept analysis methods from Walker and Avant were used to define the concepts for comparison. Conceptual definitions, process descriptions, examples (i.e., model cases), and methods of evaluation are offered for EBD and RID. Although EBD and RID share similarities in meaning, the two terms are distinct. When comparing evidence based (EB) and research informed, EB is a broad base of information types (evidence) that are narrowly applied (based), while the latter references a narrow slice of information (research) that is broadly applied (informed) to create an end product of design. Much of the confusion between the use of the concepts EBD and RID arises out of differing perspectives between the way practitioners and academics understand the underlying terms. The authors hope this article serves to generate thoughtful dialogue, which is essential to the development of a discipline, and look forward to the contribution of the readership.

Adapting participatory design to design information system with rural Ethiopian community

DEFF Research Database (Denmark)

Zewge, Amanuel; Dittrich, Yvonne; Bekele, Rahel

2015-01-01

Most of the Information and Communication Technology for Development initiatives introduced to communities in developing countries fails to deliver its promises due to the lack of intended beneficiary involvement. Participatory Design assumes to be effective as long as its nature of participations...... and methods are contextualized to a given settings. To this end, we discuss the implication of considering local (rural community) culture of participation practices, and propose a procedure to be followed in the early phases of information system development process. Finally we argue that, such adaption...... could advance the Participatory Action Research methodology....

The intensity of emotional feelings: Product of peripheral emotional responses or cognitions?

NARCIS (Netherlands)

Bermond, B.; Frijda, N.H.

1987-01-01

Reviews the function of peripheral feedback for emotions and theories describing emotions as information-processing systems. Cognitive processes are seen as a necessary condition for most human emotional experiences. Coping difficulties and degree of harmful or favorable appraisal have been

Long term clinical outcome of peripheral nerve stimulation in patients with chronic peripheral neuropathic pain

DEFF Research Database (Denmark)

Calenbergh, F. Van; Gybels, J.; Laere, K. Van

2009-01-01

BACKGROUND: Chronic neuropathic pain after injury to a peripheral nerve is known to be resistant to treatment. Peripheral nerve stimulation is one of the possible treatment options, which is, however, not performed frequently. In recent years we have witnessed a renewed interest for PNS. The aim...... of the present study was to evaluate the long-term clinical efficacy of PNS in a group of patients with peripheral neuropathic pain treated with PNS since the 1980s. METHODS: Of an original series of 11 patients, 5 patients could be invited for clinical examination, detailed assessment of clinical pain and QST...... functioning) also showed positive effects. Quantitative Sensory Testing results did not show significant differences in cold pain and heat pain thresholds between the "ON" and "OFF" conditions. CONCLUSION: In selected patients with peripheral neuropathic pain PNS remains effective even after more than 20...

The socio-technical design of a library and information science collaboratory

DEFF Research Database (Denmark)

Lassi, Monica; Sonnenwald, Diane H.

2013-01-01

Introduction. We present a prototype collaboratory, a socio-technical platform to support sharing research data collection instruments in library and information science. No previous collaboratory has attempted to facilitate sharing digital research data collection instruments among library...... and information science researchers.  Method. We have taken a socio-technical approach to design, which includes a review of previous research on collaboratories; an empirical study of specific needs of library and information science researchers; and a use case design method to design the prototype collaboratory....... Scenarios of future interactions, use cases, were developed using an analytically-driven approach to scenario design. The use cases guided the implementation of the prototype collaboratory in the MediaWiki software package.  Results. The prototype collaboratory design is presented as seven use cases, which...

Online by design the essentials of creating information literacy courses

CERN Document Server

Mery, Yvonne

2014-01-01

As online instruction becomes more popular, librarians will want to develop the knowledge and skills needed to create an effective online information literacy course. Online by Design: The Essentials of Creating Information Literacy Courses will guide librarians as they go through the process of designing, developing, and delivering online information literacy courses. Yvonne Mery & Jill Newby offer proven techniques and tips for creating quality online courses that are engaging and effective. This handbook is perfect for instruction librarians who are interesting in developing new courses or

What do information reuse and automated processing require in engineering design? Semantic process

Directory of Open Access Journals (Sweden)

Ossi Nykänen

2011-12-01

Full Text Available Purpose: The purpose of this study is to characterize, analyze, and demonstrate machine-understandable semantic process for validating, integrating, and processing technical design information. This establishes both a vision and tools for information reuse and semi-automatic processing in engineering design projects, including virtual machine laboratory applications with generated components.Design/methodology/approach: The process model has been developed iteratively in terms of action research, constrained by the existing technical design practices and assumptions (design documents, expert feedback, available technologies (pre-studies and experiments with scripting and pipeline tools, benchmarking with other process models and methods (notably the RUP and DITA, and formal requirements (computability and the critical information paths for the generated applications. In practice, the work includes both quantitative and qualitative components.Findings: Technical design processes may be greatly enhanced in terms of semantic process thinking, by enriching design information, and automating information validation and transformation tasks. Contemporary design information, however, is mainly intended for human consumption, and needs to be explicitly enriched with the currently missing data and interfaces. In practice, this may require acknowledging the role of technical information or knowledge engineer, to lead the development of the semantic design information process in a design organization. There is also a trade-off between machine-readability and system complexity that needs to be studied further, both empirically and in theory.Research limitations/implications: The conceptualization of the semantic process is essentially an abstraction based on the idea of progressive design. While this effectively allows implementing semantic processes with, e.g., pipeline technologies, the abstraction is valid only when technical design is organized into

Blood-informative transcripts define nine common axes of peripheral blood gene expression.

Directory of Open Access Journals (Sweden)

Marcela Preininger

Full Text Available We describe a novel approach to capturing the covariance structure of peripheral blood gene expression that relies on the identification of highly conserved Axes of variation. Starting with a comparison of microarray transcriptome profiles for a new dataset of 189 healthy adult participants in the Emory-Georgia Tech Center for Health Discovery and Well-Being (CHDWB cohort, with a previously published study of 208 adult Moroccans, we identify nine Axes each with between 99 and 1,028 strongly co-regulated transcripts in common. Each axis is enriched for gene ontology categories related to sub-classes of blood and immune function, including T-cell and B-cell physiology and innate, adaptive, and anti-viral responses. Conservation of the Axes is demonstrated in each of five additional population-based gene expression profiling studies, one of which is robustly associated with Body Mass Index in the CHDWB as well as Finnish and Australian cohorts. Furthermore, ten tightly co-regulated genes can be used to define each Axis as "Blood Informative Transcripts" (BITs, generating scores that define an individual with respect to the represented immune activity and blood physiology. We show that environmental factors, including lifestyle differences in Morocco and infection leading to active or latent tuberculosis, significantly impact specific axes, but that there is also significant heritability for the Axis scores. In the context of personalized medicine, reanalysis of the longitudinal profile of one individual during and after infection with two respiratory viruses demonstrates that specific axes also characterize clinical incidents. This mode of analysis suggests the view that, rather than unique subsets of genes marking each class of disease, differential expression reflects movement along the major normal Axes in response to environmental and genetic stimuli.

Blood-informative transcripts define nine common axes of peripheral blood gene expression.

Science.gov (United States)

Preininger, Marcela; Arafat, Dalia; Kim, Jinhee; Nath, Artika P; Idaghdour, Youssef; Brigham, Kenneth L; Gibson, Greg

2013-01-01

We describe a novel approach to capturing the covariance structure of peripheral blood gene expression that relies on the identification of highly conserved Axes of variation. Starting with a comparison of microarray transcriptome profiles for a new dataset of 189 healthy adult participants in the Emory-Georgia Tech Center for Health Discovery and Well-Being (CHDWB) cohort, with a previously published study of 208 adult Moroccans, we identify nine Axes each with between 99 and 1,028 strongly co-regulated transcripts in common. Each axis is enriched for gene ontology categories related to sub-classes of blood and immune function, including T-cell and B-cell physiology and innate, adaptive, and anti-viral responses. Conservation of the Axes is demonstrated in each of five additional population-based gene expression profiling studies, one of which is robustly associated with Body Mass Index in the CHDWB as well as Finnish and Australian cohorts. Furthermore, ten tightly co-regulated genes can be used to define each Axis as "Blood Informative Transcripts" (BITs), generating scores that define an individual with respect to the represented immune activity and blood physiology. We show that environmental factors, including lifestyle differences in Morocco and infection leading to active or latent tuberculosis, significantly impact specific axes, but that there is also significant heritability for the Axis scores. In the context of personalized medicine, reanalysis of the longitudinal profile of one individual during and after infection with two respiratory viruses demonstrates that specific axes also characterize clinical incidents. This mode of analysis suggests the view that, rather than unique subsets of genes marking each class of disease, differential expression reflects movement along the major normal Axes in response to environmental and genetic stimuli.

Embedded Design Research of Iris Information Acquisition System

Directory of Open Access Journals (Sweden)

Huiyan Xu

2014-09-01

Full Text Available In view of the limitation of traditional identification, it is easy to lose and copy keys, cards or ID cards, and it is easy to forget the password, so we designed an embedded application system based on the iris identification technology, which can realize the functions of gathering, inputting, and registering the iris information and identification. The hardware circuit was designed by using advanced RISC machines (ARM embedded microprocessor as the core. The iris sensor was used to gather the iris information, and the development of software was accomplished with the embedded OS Windows CE. The system can be used on the company entrance guard system, customs security of airport and criminal identification.

Polarization information processing and software system design for simultaneously imaging polarimetry

Science.gov (United States)

Wang, Yahui; Liu, Jing; Jin, Weiqi; Wen, Renjie

2015-08-01

Simultaneous imaging polarimetry can realize real-time polarization imaging of the dynamic scene, which has wide application prospect. This paper first briefly illustrates the design of the double separate Wollaston Prism simultaneous imaging polarimetry, and then emphases are put on the polarization information processing methods and software system design for the designed polarimetry. Polarization information processing methods consist of adaptive image segmentation, high-accuracy image registration, instrument matrix calibration. Morphological image processing was used for image segmentation by taking dilation of an image; The accuracy of image registration can reach 0.1 pixel based on the spatial and frequency domain cross-correlation; Instrument matrix calibration adopted four-point calibration method. The software system was implemented under Windows environment based on C++ programming language, which realized synchronous polarization images acquisition and preservation, image processing and polarization information extraction and display. Polarization data obtained with the designed polarimetry shows that: the polarization information processing methods and its software system effectively performs live realize polarization measurement of the four Stokes parameters of a scene. The polarization information processing methods effectively improved the polarization detection accuracy.

Information Systems at Enterprise. Design of Secure Network of Enterprise

Science.gov (United States)

Saigushev, N. Y.; Mikhailova, U. V.; Vedeneeva, O. A.; Tsaran, A. A.

2018-05-01

No enterprise and company can do without designing its own corporate network in today's information society. It accelerates and facilitates the work of employees at any level, but contains a big threat to confidential information of the company. In addition to the data theft attackers, there are plenty of information threats posed by modern malware effects. In this regard, the computational security of corporate networks is an important component of modern information technologies of computer security for any enterprise. This article says about the design of the protected corporate network of the enterprise that provides the computers on the network access to the Internet, as well interoperability with the branch. The access speed to the Internet at a high level is provided through the use of high-speed access channels and load balancing between devices. The security of the designed network is performed through the use of VLAN technology as well as access lists and AAA server.

Normal and sonographic anatomy of selected peripheral nerves. Part III: Peripheral nerves of the lower limb.

Science.gov (United States)

Kowalska, Berta; Sudoł-Szopińska, Iwona

2012-06-01

The ultrasonographic examination is currently increasingly used in imaging peripheral nerves, serving to supplement the physical examination, electromyography and magnetic resonance imaging. As in the case of other USG imaging studies, the examination of peripheral nerves is non-invasive and well-tolerated by patients. The typical ultrasonographic picture of peripheral nerves as well as the examination technique have been discussed in part I of this article series, following the example of the median nerve. Part II of the series presented the normal anatomy and the technique for examining the peripheral nerves of the upper limb. This part of the article series focuses on the anatomy and technique for examining twelve normal peripheral nerves of the lower extremity: the iliohypogastric and ilioinguinal nerves, the lateral cutaneous nerve of the thigh, the pudendal, sciatic, tibial, sural, medial plantar, lateral plantar, common peroneal, deep peroneal and superficial peroneal nerves. It includes diagrams showing the proper positioning of the sonographic probe, plus USG images of the successively discussed nerves and their surrounding structures. The ultrasonographic appearance of the peripheral nerves in the lower limb is identical to the nerves in the upper limb. However, when imaging the lower extremity, convex probes are more often utilized, to capture deeply-seated nerves. The examination technique, similarly to that used in visualizing the nerves of upper extremity, consists of locating the nerve at a characteristic anatomic reference point and tracking it using the "elevator technique". All 3 parts of the article series should serve as an introduction to a discussion of peripheral nerve pathologies, which will be presented in subsequent issues of the "Journal of Ultrasonography".

Treatment of painful diabetic peripheral neuropathy.

Science.gov (United States)

Rosenberg, Casandra J; Watson, James C

2015-02-01

Painful diabetic peripheral neuropathy impairs quality of life and can be difficult to treat. To discuss current treatment recommendations for painful diabetic peripheral neuropathy. Literature review. Systematic review of the literature discussing treatment of painful diabetic peripheral neuropathy. Existing treatment guidelines were studied and compared. Painful diabetic peripheral neuropathy occurs in about one in six people with diabetes. This condition impairs quality of life and increases healthcare costs. Treatment recommendations exist, but individual patient therapy can require a trial-and-error approach. Many treatment options have adjuvant benefits or side effects which should be considered prior to initiating therapy. Often, a combination of treatment modalities with various mechanisms of action is required for adequate pain control. Adequate medication titration and a reasonable trial period should be allowed. The treatment of painful diabetic peripheral neuropathy can be challenging, but effective management can improve patient's quality of life. Painful diabetic peripheral neuropathy impairs quality of life and can be difficult to treat. Many treatment options have adjuvant benefits or side effects which should be considered prior to initiating therapy. Often, a combination of treatment modalities with various mechanisms of action is required for adequate pain control. © The International Society for Prosthetics and Orthotics 2014.

Design information questionnaire for a model mixed oxide fuel fabrication facility

International Nuclear Information System (INIS)

Glancy, J.E.

1976-05-01

The model fuel plant is based on the proposed Westinghouse Anderson, S.C., plant and is typical of plants that will be constructed and operated in 1980 to 1990. A number of plant systems and procedures are uncertain, and in these cases judgment was used in describing relevant parameters in order to provide a complete model on which to design an inspection plan. The model plant does not, therefore, strictly represent any planned facility nor does it strictly represent the ideas of Westinghouse on plant design and material accountability. This report is divided into two sections. The first section is the IAEA Design Information Questionnaire form that contains an outline of all information requested. The second section is a complete listing of design information

Data Visualization and Infographics In Visual Communication Design Education at The Age of Information

Directory of Open Access Journals (Sweden)

Banu Inanc Uyan Dur

2014-06-01

Full Text Available Scientific and technologic developments in the last century facilitate people’s lives while also causing them to face more information. Information design has become much more important as a result of the chaos created by the unprocessed heap of data and information traffic. Therefore, people need designed information like infographics and data visualisation today. Design of information, which is among the most significant requirements of our age, has become a subject which needs to be dealt with more systematically in the education of visual communication design. Visual design of information and data is important not only for increasing perceptibility but also revealing the patterns within complex information, and being educative, persuasive and guiding depending on the content and objective. In this sense, incorporating data visualization and infographics works into the education of visual communication design would have significant contributions to train designers with sufficient qualification to meet the requirements of today’s world. This study examines the current/potential expansion of data visualization and infographics in the education of visual communication design  at the age of information. With respect to students, it deals with its effects to the design method, process and perception and its contributions to the multidisciplinary design approach.

Information about robustness, reliability and safety in early design phases

DEFF Research Database (Denmark)

Marini, Vinicius Kaster

methods, and an industrial case to assess how the use of information about robustness, reliability and safety as practised by current methods influences concept development. Current methods cannot be used in early design phases due to their dependence on detailed design information for the identification...... alternatives. This prompts designers to reuse working principles that are inherently flawed, as they are liable to disturbances, failures and hazards. To address this issue, an approach based upon individual records of early design issues consists of comparing failures and benefits from prior working...... principles, before making a decision, and improving the more suitable alternatives through this feedback. Workshops were conducted with design practitioners to evaluate the potential of the approach and to simulate decision-making and gain feedback on a proof-of-concept basis. The evaluation has demonstrated...

Promoting peripheral myelin repair.

Science.gov (United States)

Zhou, Ye; Notterpek, Lucia

2016-09-01

Compared to the central nervous system (CNS), peripheral nerves have a remarkable ability to regenerate and remyelinate. This regenerative capacity to a large extent is dependent on and supported by Schwann cells, the myelin-forming glial cells of the peripheral nervous system (PNS). In a variety of paradigms, Schwann cells are critical in the removal of the degenerated tissue, which is followed by remyelination of newly-regenerated axons. This unique plasticity of Schwann cells has been the target of myelin repair strategies in acute injuries and chronic diseases, such as hereditary demyelinating neuropathies. In one approach, the endogenous regenerative capacity of Schwann cells is enhanced through interventions such as exercise, electrical stimulation or pharmacological means. Alternatively, Schwann cells derived from healthy nerves, or engineered from different tissue sources have been transplanted into the PNS to support remyelination. These transplant approaches can then be further enhanced by exercise and/or electrical stimulation, as well as by the inclusion of biomaterial engineered to support glial cell viability and neurite extension. Advances in our basic understanding of peripheral nerve biology, as well as biomaterial engineering, will further improve the functional repair of myelinated peripheral nerves. Copyright © 2016 Elsevier Inc. All rights reserved.

Understanding Teachers' Routines to Inform Classroom Technology Design

Science.gov (United States)

An, Pengcheng; Bakker, Saskia; Eggen, Berry

2017-01-01

Secondary school teachers have quite busy and complex routines in their classrooms. However, present classroom technologies usually require focused attention from teachers while being interacted with, which restricts their use in teachers' daily routines. Peripheral interaction is a human-computer interaction style that aims to enable interaction…

Peripheral Vestibular System Disease in Vestibular Schwannomas

DEFF Research Database (Denmark)

Møller, Martin Nue; Hansen, Søren; Caye-Thomasen, Per

2015-01-01

density of the peripheral vestibular nerve branches, and atrophy of the neuroepithelium of the vestibular end organs. In cases with small tumors, peripheral disease occurred only in the tissue structures innervated by the specific nerve from which the tumor originated. CONCLUSION: Vestibular schwannomas...... are associated with distinctive disease of the peripheral vestibular tissue structures, suggesting anterograde degeneration and that dizziness in these patients may be caused by deficient peripheral vestibular nerve fibers, neurons, and end organs. In smaller tumors, a highly localized disease occurs, which...

SU-F-T-473: Evaluation of Off-Axis And Peripheral Dose Using Different Detectors

Energy Technology Data Exchange (ETDEWEB)

Ganesan, B; Prakasarao, A; Singaravelu, G [Anna University, Chennai, TamilNadu (India); Palraj, T; Rai, R [Dr. Rai Memorial Cancer Institute, Chennai, TamilNadu (India)

2016-06-15

Purpose: In radiation therapy, measurement of off-axis and peripheral dose is a tedious task. The dose distribution along the beam central axis give only part of the information required for an accurate dose description inside the patient. Dose distributions in 2-D and 3-D are determined with central axis data in conjunction with off-axis dose profiles. Combining a central axis dose distribution with off-axis data results in volume dose matrix that provides 2-D and 3-D information on dose distribution. By considering the importance of these two parameters this study investigates and compares the off axis and peripheral dose measurement using Ionization chamber, MOSFET, Radiochromic film and EDR2 film. Methods: In the measurement of off-axis and peripheral doses 0.6cc farmer type chamber, EDR-2 film, MD-55 radiochromic film and MOSFET detectors were used for both 6MV and 15MV beams. The off-axis and peripheral dose was measured at every 1 cm interval by changing the position of the couch without disturbing the other experimental setup in particular, the phantom with detector position. Results: Readings were obtained for both 6MV and 15MV photon beams at SSD technique for various field size using MOSFET, Ionization chamber and Radiochromic film. The results shows the percentage difference between various detectors for various field sizes. For Peripheral dose measurement were taken from the edge of the field size and for off axis it is measured form central axis dose. Conclusion: In conclusion, our study shows that no detector is ideal and only a comparison between different detectors highlights the weaknesses of each detector. MOSFET provides adequate dose assessment in off-axis and peripheral regions in 6MV and 15MV photon beams. Film dosimetry in general a convenient method to generate one- and two-dimensional dose distributions. The result of this indicates that MOSFET is flexible tool for relative dosimetry as films.

Ergonomic design in the operating room: information technologies

Science.gov (United States)

Morita, Mark M.; Ratib, Osman

2005-04-01

The ergonomic design in the Surgical OR of information technology systems has been and continues to be a large problem. Numerous disparate information systems with unique hardware and display configurations create an environment similar to the chaotic environments of air traffic control. Patient information systems tend to show all available statistics making it difficult to isolate the key, relevant vitals for the patient. Interactions in this sterile environment are still being done with the traditional keyboard and mouse designed for cubicle office workflows. This presentation will address the shortcomings of the current design paradigm in the Surgical OR that relate to Information Technology systems. It will offer a perspective that addresses the ergonomic deficiencies and predicts how future technological innovations will integrate into this vision. Part of this vision includes a Surgical OR PACS prototype, developed by GE Healthcare Technologies, that addresses ergonomic challenges of PACS in the OR that include lack of portability, sterile field integrity, and UI targeted for diagnostic radiologists. GWindows (gesture control) developed by Microsoft Research and Voice command will allow for the surgeons to navigate and review diagnostic imagery without using the conventional keyboard and mouse that disrupt the integrity of the sterile field. This prototype also demonstrates how a wireless, battery powered, self contained mobile PACS workstation can be optimally positioned for a surgeon to reference images during an intervention as opposed to the current pre-operative review. Lessons learned from the creation of the Surgical OR PACS Prototype have demonstrated that PACS alone is not the end all solution in the OR. Integration of other disparate information systems and presentation of this information in simple, easy to navigate information packets will enable smoother interactions for the surgeons and other healthcare professionals in the OR. More intuitive

Photoproduction of ρ0 and Two–photon Production of Lepton Pairs in Ultra–peripheral Pb–Pb Collisions at the CERN LHC

CERN Document Server

Kyrre, Skjerdal

This thesis is based on the analysis of ultra–peripheral collisions collected by the ALICE Collaboration at the CERN LHC. ALICE is a general purpose detector designed to study heavy-ion collisions at ultra–relativistic energies with the purpose of investigating the properties of strongly interacting matter, similar to the matter that existed shortly after the Big Bang. In this analysis the charged particle tracking system of the central barrel in ALICE is used. The tracking system consists of an Inner Tracking System, with six layers of silicon detectors, and a large Time Projection Chamber. Trigger information is provided by the following detectors: The Silicon-Pixel Detector (SPD), a part of the Inner Tracking System; the Time–Of–Flight (TOF), located outside the TPC; the V0 detectors, plastic scintillators located outside of the central barrel, covering roughly two units of pseudorapidity on either side of mid-rapidity. Ultra–peripheral collisions are collisions between hadrons, they can be pro...

Formal and informal computer mediated communication within within design teams for complex building projects

NARCIS (Netherlands)

Otter, den A.F.H.J.; Gray, C.; Prins, M.

2001-01-01

In this paper the information environment of design teams is discussed because of the use of Internet based Project websites (PWS) to improve the information exchange within design teams. Because design teams heavenly depend on informal information exchange and PWS is a tool for formalising

Implications of Building Information Modeling on Interior Design Education: The Impact on Teaching Design Processes

Directory of Open Access Journals (Sweden)

Amy Roehl, MFA

2013-06-01

Full Text Available Currently, major shifts occur in design processes effecting business practices for industries involved with designing and delivering the built environment. These changing conditions are a direct result of industry adoption of relatively new technologies called BIM or Building Information Modeling. This review of literature examines implications of these changing processes on interior design education.

Intrinsic information Security: Embedding security issues in the design process of telematics systems

NARCIS (Netherlands)

Tettero, Olaf; Tettero, O.

This book presents a systematic approach to embed information security issues in the design process of telematics systems. The approach supports both designers and user organisations. We elaborate on the activities that designers should perform to design telematics systems in which information

A Program for Introducing Information Literacy to Commercial Art and Design Students

Directory of Open Access Journals (Sweden)

David A. Walczak

2010-03-01

Full Text Available This paper describes the process of developing and implementing a comprehensive, school-wide, and sustainable information literacy program at a commercial art and design school. The program requires that information literacy student learning outcomes be included in specific General Education and art and design courses across the curriculum. The results of this multi-year effort indicate that while the program is sound, teaching information literacy is an on-going effort requiring much more training of faculty and students. Best practices in information literacy in library science and art and design literature are reviewed

Paradigms for adaptive statistical information designs: practical experiences and strategies.

Science.gov (United States)

Wang, Sue-Jane; Hung, H M James; O'Neill, Robert

2012-11-10

In the last decade or so, interest in adaptive design clinical trials has gradually been directed towards their use in regulatory submissions by pharmaceutical drug sponsors to evaluate investigational new drugs. Methodological advances of adaptive designs are abundant in the statistical literature since the 1970s. The adaptive design paradigm has been enthusiastically perceived to increase the efficiency and to be more cost-effective than the fixed design paradigm for drug development. Much interest in adaptive designs is in those studies with two-stages, where stage 1 is exploratory and stage 2 depends upon stage 1 results, but where the data of both stages will be combined to yield statistical evidence for use as that of a pivotal registration trial. It was not until the recent release of the US Food and Drug Administration Draft Guidance for Industry on Adaptive Design Clinical Trials for Drugs and Biologics (2010) that the boundaries of flexibility for adaptive designs were specifically considered for regulatory purposes, including what are exploratory goals, and what are the goals of adequate and well-controlled (A&WC) trials (2002). The guidance carefully described these distinctions in an attempt to minimize the confusion between the goals of preliminary learning phases of drug development, which are inherently substantially uncertain, and the definitive inference-based phases of drug development. In this paper, in addition to discussing some aspects of adaptive designs in a confirmatory study setting, we underscore the value of adaptive designs when used in exploratory trials to improve planning of subsequent A&WC trials. One type of adaptation that is receiving attention is the re-estimation of the sample size during the course of the trial. We refer to this type of adaptation as an adaptive statistical information design. Specifically, a case example is used to illustrate how challenging it is to plan a confirmatory adaptive statistical information

Principles and Concepts for Information and Communication Technology Design.

Science.gov (United States)

Adams, Ray; Langdon, Patrick

2003-01-01

This article presents a theory for evaluating information and communication technology design for individuals with disabilities. Simplex 1 evaluates designs in five zones: sensory and input zone; output zone; abstract working memory; long-term memory; and central executive functioning. Simplex 2 evaluates feedback, emotional responses, cognitive…

Usability of consumer-related information sources for design improvement

NARCIS (Netherlands)

Thiruvenkadam, G.; Brombacher, A.C.; Lu, Y.; Ouden, den P.H.

2008-01-01

In this paper we report the findings of a study intended to assess the usability of consumer related information sources in order to improve the design processes of innovative electronic products. Specifically, an evaluation is done of the quality and content of information that would help product

Modeling peripheral olfactory coding in Drosophila larvae.

Directory of Open Access Journals (Sweden)

Derek J Hoare

Full Text Available The Drosophila larva possesses just 21 unique and identifiable pairs of olfactory sensory neurons (OSNs, enabling investigation of the contribution of individual OSN classes to the peripheral olfactory code. We combined electrophysiological and computational modeling to explore the nature of the peripheral olfactory code in situ. We recorded firing responses of 19/21 OSNs to a panel of 19 odors. This was achieved by creating larvae expressing just one functioning class of odorant receptor, and hence OSN. Odor response profiles of each OSN class were highly specific and unique. However many OSN-odor pairs yielded variable responses, some of which were statistically indistinguishable from background activity. We used these electrophysiological data, incorporating both responses and spontaneous firing activity, to develop a bayesian decoding model of olfactory processing. The model was able to accurately predict odor identity from raw OSN responses; prediction accuracy ranged from 12%-77% (mean for all odors 45.2% but was always significantly above chance (5.6%. However, there was no correlation between prediction accuracy for a given odor and the strength of responses of wild-type larvae to the same odor in a behavioral assay. We also used the model to predict the ability of the code to discriminate between pairs of odors. Some of these predictions were supported in a behavioral discrimination (masking assay but others were not. We conclude that our model of the peripheral code represents basic features of odor detection and discrimination, yielding insights into the information available to higher processing structures in the brain.

Hypothyroidism: Can It Cause Peripheral Neuropathy?

Science.gov (United States)

Hypothyroidism: Can it cause peripheral neuropathy? Can hypothyroidism cause peripheral neuropathy and, if so, how is it treated? Answers from Todd B. Nippoldt, M.D. Hypothyroidism — a condition in which your ...

A model of designing as the intersection between uncertainty perception, information processing, and coevolution

DEFF Research Database (Denmark)

Lasso, Sarah Venturim; Cash, Philip; Daalhuizen, Jaap

2016-01-01

, the designer's perceived uncertainty is the motivation to start a process of collecting, exchanging, and integrating knowledge. This has been formalised in Information-Processing Theory and more generally described by authors such as Aurisicchio et al. (2013) who describe design as an information...... takes the first steps towards linking these disparate perspectives in a model of designing that synthesises coevolution and information processing. How designers act has been shown to play an important role in the process of New Product Development (NPD) (See e.g. Badke-Schaub and Frankenberger, 2012...... transformation process. Here the aim of the activity is to reduce the perceived uncertainty through identifying and integrating external information and knowledge within the design team. For2example, when perceiving uncertainty the designer might seek new information online, process this information, and share...

Peripheral ameloblastic fibro-odontoma or peripheral developing complex odontoma: report of a case

DEFF Research Database (Denmark)

Reibel, Jesper; Grønbæk, Anni Birgitte; Poulsen, Sven

2011-01-01

BACKGROUND. Peripheral (extraosseous) odontogenic tumors are rare. CASE REPORT. This report describes a case which illustrates the clinical and histopathological features of a lesion in an 8-year-old, healthy Caucasian girl that on purely morphological grounds would seem to be an ameloblastic fibro-odontoma......, but may represent a case of a peripheral developing complex odontoma. CONCLUSION. Conservative surgical enucleation of the lesion was followed by unbcomplicated healing and no recurrence was seen....

A Strategic Approach to Curriculum Design for Information Literacy in Teacher Education--Implementing an Information Literacy Conceptual Framework

Science.gov (United States)

Klebansky, Anna; Fraser, Sharon P.

2013-01-01

This paper details a conceptual framework that situates curriculum design for information literacy and lifelong learning, through a cohesive developmental information literacy based model for learning, at the core of teacher education courses at UTAS. The implementation of the framework facilitates curriculum design that systematically,…

Information Flow Through Stages of Complex Engineering Design Projects: A Dynamic Network Analysis Approach

DEFF Research Database (Denmark)

Parraguez, Pedro; Eppinger, Steven D.; Maier, Anja

2015-01-01

The pattern of information flow through the network of interdependent design activities is thought to be an important determinant of engineering design process results. A previously unexplored aspect of such patterns relates to the temporal dynamics of information transfer between activities...... design process and thus support theory-building toward the evolution of information flows through systems engineering stages. Implications include guidance on how to analyze and predict information flows as well as better planning of information flows in engineering design projects according...

Promoting peripheral myelin repair

OpenAIRE

Zhou, Ye; Notterpek, Lucia

2016-01-01

Compared to the central nervous system (CNS), peripheral nerves have a remarkable ability to regenerate and remyelinate. This regenerative capacity to a large extent is dependent on and supported by Schwann cells, the myelin-forming glial cells of the peripheral nervous system (PNS). In a variety of paradigms, Schwann cells are critical in the removal of the degenerated tissue, which is followed by remyelination of newly-regenerated axons. This unique plasticity of Schwann cells has been the ...

Test Information Targeting Strategies for Adaptive Multistage Testing Designs.

Science.gov (United States)

Luecht, Richard M.; Burgin, William

Adaptive multistage testlet (MST) designs appear to be gaining popularity for many large-scale computer-based testing programs. These adaptive MST designs use a modularized configuration of preconstructed testlets and embedded score-routing schemes to prepackage different forms of an adaptive test. The conditional information targeting (CIT)…

Information Display: Considerations for Designing Modern Computer-Based Display Systems

International Nuclear Information System (INIS)

O'Hara, J.; Pirus, D.; Beltracchi, L.

2003-01-01

OAK- B135 To help nuclear utilities and suppliers design and implement plant information management systems and displays that provide accurate and timely information and require minimal navigation and interface management

Peripheral cemento-ossifying fibroma of maxilla.

Science.gov (United States)

Chatterjee, Anirban; Ajmera, Neha; Singh, Amit

2010-07-01

Peripheral cemento-ossifying fibroma is a reactive gingival overgrowth occurring frequently in anterior maxilla. It is a slow-growing benign tumor which may lead to pathologic migration and other periodontal problems, so it should be excised as soon as possible. The recurrence rate of peripheral cemento-ossifying fibroma is reported to be 8% to 20%, so a close postoperative follow-up is required. Herein, we are reporting a similar case of peripheral cemento-ossifying fibroma in the maxillary anterior region.

The Skills Framework for the Information Age: Engaging Stakeholders in Curriculum Design

Science.gov (United States)

von Konsky, Brian R.; Miller, Charlynn; Jones, Asheley

2016-01-01

This paper reports on a research project, examining the role of the Skills Framework for the Information Age (SFIA) in Information and Communications Technology (ICT) curriculum design and management. A goal was to investigate how SFIA informs a top-down approach to curriculum design, beginning with a set of skills that define a particular career…

Coaching Peripheral Vision Training for Soccer Athletes

Science.gov (United States)

Marques, Nelson Kautzner, Jr.

2010-01-01

Brazilian Soccer began developing its current emphasis on peripheral vision in the late 1950s, by initiative of coach of the Canto do Rio Football Club, in Niteroi, Rio de Janeiro, a pioneer in the development of peripheral vision training in soccer players. Peripheral vision training gained world relevance when a young talent from Canto do Rio,…

Design Information from the PSA for Digital Safety-Critical Systems

International Nuclear Information System (INIS)

Kang, Hyun Gook; Jang, Seung Cheol

2005-01-01

Many safety-critical applications such as nuclear field application usually adopt a similar design strategy for digital safety-critical systems. Their differences from the normal design for the non-safety-critical applications could be summarized as: multiple-redundancy, highly reliable components, strengthened monitoring mechanism, verified software, and automated test procedure. These items are focusing on maintaining the capability to perform the given safety function when it is requested. For the past several decades, probabilistic safety assessment (PSA) techniques are used in the nuclear industry to assess the relative effects of contributing events on plant risk and system reliability. They provide a unifying means of assessing physical faults, recovery processes, contributing effects, human actions, and other events that have a high degree of uncertainty. The applications of PSA provide not only the analysis results of already installed system but also the useful information for the system under design. The information could be derived from the PSA experience of the various safety-critical systems. Thanks to the design flexibility, the digital system is one of the most suitable candidates for risk-informed design (RID). In this article, we will describe the feedbacks for system design and try to develop a procedure for RID. Even though the procedure is not sophisticated enough now, it could be the start point of the further investigation for developing more complete and practical methodology

[Ultrasound-guided peripheral catheterization].

Science.gov (United States)

Salleras-Duran, Laia; Fuentes-Pumarola, Concepció

2016-01-01

Peripheral catheterization is a technique that can be difficult in some patients. Some studies have recently described the use of ultrasound to guide the venous catheterization. To describe the success rate, time required, complications of ultrasound-guided peripheral venous catheterization. and patients and professionals satisfaction The search was performed in databases (Medline-PubMed, Cochrane Library, CINAHL and Cuiden Plus) for studies published about ultrasound-guided peripheral venous catheterization performed on patients that provided results on the success of the technique, complications, time used, patient satisfaction and the type of professional who performed the technique. A total of 21 studies were included. Most of them get a higher success rate 80% in the catheterization ecoguide and time it is not higher than the traditional technique. The Technical complications analyzed were arterial puncture rates and lower nerve 10%. In all studies measuring and comparing patient satisfaction in the art ecoguide is greater. Various professional groups perform the technique. The use of ultrasound for peripheral pipes has a high success rate, complications are rare and the time used is similar to that of the traditional technique. The technique of inserting catheters through ultrasound may be learned by any professional group performing venipuncture. Finally, it gets underscores the high patient satisfaction with the use of this technique. Copyright © 2015 Elsevier España, S.L.U. All rights reserved.

Normal and sonographic anatomy of selected peripheral nerves. Part III: Peripheral nerves of the lower limb

Directory of Open Access Journals (Sweden)

Berta Kowalska

2012-06-01

Full Text Available The ultrasonographic examination is currently increasingly used in imaging peripheral nerves, serving to supplement the physical examination, electromyography and magnetic resonance imaging. As in the case of other USG imaging studies, the examination of peripheral nerves is non-invasive and well-tolerated by patients. The typical ultrasonographic picture of peripheral nerves as well as the examination technique have been discussed in part I of this article series, following the example of the median nerve. Part II of the series presented the normal anatomy and the technique for examining the peripheral nerves of the upper limb. This part of the article series focuses on the anatomy and technique for examining twelve normal peripheral nerves of the lower extremity: the iliohypogastric and ilioinguinal nerves, the lateral cutaneous nerve of the thigh, the pudendal, sciatic, tibial, sural, medial plantar, lateral plantar, common peroneal, deep peroneal and superficial peroneal nerves. It includes diagrams showing the proper positioning of the sonographic probe, plus USG images of the successively discussed nerves and their surrounding structures. The ultrasonographic appearance of the peripheral nerves in the lower limb is identical to the nerves in the upper limb. However, when imaging the lower extremity, convex probes are more often utilized, to capture deeply-seated nerves. The examination technique, similarly to that used in visualizing the nerves of upper extremity, consists of locating the nerve at a characteristic anatomic reference point and tracking it using the “elevator technique”. All 3 parts of the article series should serve as an introduction to a discussion of peripheral nerve pathologies, which will be presented in subsequent issues of the “Journal of Ultrasonography”.

Analysis and design on airport safety information management system

Directory of Open Access Journals (Sweden)

Yan Lin

2017-01-01

Full Text Available Airport safety information management system is the foundation of implementing safety operation, risk control, safety performance monitor, and safety management decision for the airport. The paper puts forward the architecture of airport safety information management system based on B/S model, focuses on safety information processing flow, designs the functional modules and proposes the supporting conditions for system operation. The system construction is helpful to perfecting the long effect mechanism driven by safety information, continually increasing airport safety management level and control proficiency．

Paclitaxel Plasma Concentration after the First Infusion Predicts Treatment-Limiting Peripheral Neuropathy.

Science.gov (United States)

Hertz, Daniel L; Kidwell, Kelley M; Vangipuram, Kiran; Li, Feng; Pai, Manjunath P; Burness, Monika; Griggs, Jennifer J; Schott, Anne F; Van Poznak, Catherine; Hayes, Daniel F; Lavoie Smith, Ellen M; Henry, N Lynn

2018-04-27

Purpose: Paclitaxel exposure, specifically the maximum concentration ( C max ) and amount of time the concentration remains above 0.05 μmol/L ( T c >0.05 ), has been associated with the occurrence of paclitaxel-induced peripheral neuropathy. The objective of this study was to validate the relationship between paclitaxel exposure and peripheral neuropathy. Experimental Design: Patients with breast cancer receiving paclitaxel 80 mg/m 2 × 12 weekly doses were enrolled in an observational clinical study (NCT02338115). Paclitaxel plasma concentration was measured at the end of and 16-26 hours after the first infusion to estimate C max and T c >0.05 Patient-reported peripheral neuropathy was collected via CIPN20 at each dose, and an 8-item sensory subscale (CIPN8) was used in the primary analysis to test for an association with T c >0.05 Secondary analyses were conducted using C max as an alternative exposure parameter and testing each parameter with a secondary endpoint of the occurrence of peripheral neuropathy-induced treatment disruption. Results: In 60 subjects included in the analysis, the increase in CIPN8 during treatment was associated with baseline CIPN8, cumulative dose, and relative dose intensity ( P 0.05 ( P = 0.27) nor C max ( P = 0.99). In analyses of the secondary endpoint, cumulative dose (OR = 1.46; 95% confidence interval (CI), 1.18-1.80; P = 0.0008) and T c >0.05 (OR = 1.79; 95% CI, 1.06-3.01; P = 0.029) or C max (OR = 2.74; 95% CI, 1.45-5.20; P = 0.002) were associated with peripheral neuropathy-induced treatment disruption. Conclusions: Paclitaxel exposure is predictive of the occurrence of treatment-limiting peripheral neuropathy in patients receiving weekly paclitaxel for breast cancer. Studies are warranted to determine whether exposure-guided dosing enhances treatment effectiveness and/or prevents peripheral neuropathy in these patients. Clin Cancer Res; 1-9. ©2018 AACR. ©2018 American Association for Cancer Research.

Irregular Shaped Building Design Optimization with Building Information Modelling

Directory of Open Access Journals (Sweden)

Lee Xia Sheng

2016-01-01

Full Text Available This research is to recognise the function of Building Information Modelling (BIM in design optimization for irregular shaped buildings. The study focuses on a conceptual irregular shaped “twisted” building design similar to some existing sculpture-like architectures. Form and function are the two most important aspects of new buildings, which are becoming more sophisticated as parts of equally sophisticated “systems” that we are living in. Nowadays, it is common to have irregular shaped or sculpture-like buildings which are very different when compared to regular buildings. Construction industry stakeholders are facing stiff challenges in many aspects such as buildability, cost effectiveness, delivery time and facility management when dealing with irregular shaped building projects. Building Information Modelling (BIM is being utilized to enable architects, engineers and constructors to gain improved visualization for irregular shaped buildings; this has a purpose of identifying critical issues before initiating physical construction work. In this study, three variations of design options differing in rotating angle: 30 degrees, 60 degrees and 90 degrees are created to conduct quantifiable comparisons. Discussions are focused on three major aspects including structural planning, usable building space, and structural constructability. This research concludes that Building Information Modelling is instrumental in facilitating design optimization for irregular shaped building. In the process of comparing different design variations, instead of just giving “yes or no” type of response, stakeholders can now easily visualize, evaluate and decide to achieve the right balance based on their own criteria. Therefore, construction project stakeholders are empowered with superior evaluation and decision making capability.

Peripheral Neuropathy – Clinical and Electrophysiological Considerations

Science.gov (United States)

Chung, Tae; Prasad, Kalpana; Lloyd, Thomas E.

2013-01-01

This article is a primer on the pathophysiology and clinical evaluation of peripheral neuropathy for the radiologist. Magnetic resonance neurography (MRN) has utility in the diagnosis of many focal peripheral nerve lesions. When combined with history, examination, electrophysiology, and laboratory data, future advancements in high-field MRN may play an increasingly important role in the evaluation of patients with peripheral neuropathy. PMID:24210312

Architectural Design for the Global Legal Information Network

Science.gov (United States)

Kalpakis, Konstantinos

1999-01-01

In this report, we provide a summary of our activities regarding the goals, requirements analysis, design, and prototype implementation for the Global Legal Information Network, a joint effort between the Law Library of Congress and NASA.

The challenges and beauty of peripheral nerve regrowth.

Science.gov (United States)

Zochodne, Douglas W

2012-03-01

This review provides an overview of selected aspects of peripheral nerve regeneration and potential avenues to explore therapeutically. The overall coordinated and orchestrated pattern of recovery from peripheral nerve injury has a beauty of execution and progress that rivals all other forms of neurobiology. It involves changes at the level of the perikaryon, coordination with important peripheral glial partners, the Schwann cells, a controlled inflammatory response, and growth that overcomes surprising intrinsic roadblocks. Both regenerative axon growth and collateral sprouting encompass fascinating aspects of this story. Better understanding of peripheral nerve regeneration may also lead to enhanced central nervous system recovery. © 2012 Peripheral Nerve Society.

Urban Planning and Management Information Systems Analysis and Design Based on GIS

Science.gov (United States)

Xin, Wang

Based on the analysis of existing relevant systems on the basis of inadequate, after a detailed investigation and research, urban planning and management information system will be designed for three-tier structure system, under the LAN using C/S mode architecture. Related functions for the system designed in accordance with the requirements of the architecture design of the functional relationships between the modules. Analysis of the relevant interface and design, data storage solutions proposed. The design for small and medium urban planning information system provides a viable building program.

Three-dimensional sound localisation with a lizard peripheral auditory model

DEFF Research Database (Denmark)

Kjær Schmidt, Michael; Shaikh, Danish

the networks learned a transfer function that translated the three-dimensional non-linear mapping into estimated azimuth and elevation values for the acoustic target. The neural network with two hidden layers as expected performed better than that with only one hidden layer. Our approach assumes that for any...... location of an acoustic target in three dimensions. Our approach utilises a model of the peripheral auditory system of lizards [Christensen-Dalsgaard and Manley 2005] coupled with a multi-layer perceptron neural network. The peripheral auditory model’s response to sound input encodes sound direction...... information in a single plane which by itself is insufficient to localise the acoustic target in three dimensions. A multi-layer perceptron neural network is used to combine two independent responses of the model, corresponding to two rotational movements, into an estimate of the sound direction in terms...

Odontogenic keratocyst: a peripheral variant.

Science.gov (United States)

Vij, H; Vij, R; Gupta, V; Sengupta, S

2011-01-01

Odontogenic keratocyst, which is developmental in nature, is an intraosseous lesion though on rare occasions it may occur in an extraosseous location. The extraosseous variant is referred to as peripheral odontogenic keratocyst. Though, clinically, peripheral odontogenic keratocyst resembles the gingival cyst of adults, it has histologic features that are pathognomonic of odontogenic keratocyst. This article presents a case of this uncommon entity.

Fabrication and Optimization of Gelatin/ Nano Bioglass Conduits for Peripheral Nerve Regeneration

Directory of Open Access Journals (Sweden)

M. Foroutan Koudehi

2014-07-01

Full Text Available Introduction & Objective: Peripheral nerve injury is common in trauma patients and 4.5% of all soft-tissue injuries are accompanied by defects of peripheral nerve. Peripheral nerve injuries can lead to lifetime loss of function and permanent disfigurement. Designed conduits com-prised of natural and synthetic materials are now widely used in the construction of damaged tissues. The aim of this project was to prepare nanocomposite conduits from gelatin and bioglass for damaged peripheral nerve reconstruction. Materials & Methods: In this experimental study,compound water solution of gelatin and nano bioglass synthesized through sol gel method, was made. After preparing the solution, special mandrels were dipped in solution several times and freeze dried in order to be emptied of wa-ter via sublimation. The conduits had the following dimensions: internal diameter: 1.6 mm, outside diameter: 2.2 mm and length about 12 mm. In order to evaluate the biocompatibility of conduits we used cytotoxicity test by Chinese ovary cells and MTT assay by Miapaca-2 (pancreatic cancer cell line. Results: The prepared nano bioglass and conduits were characterized using transmission elec-tron microscopy, scanning electron microscopy, fourier transformed infrared spectroscopy and X-ray diffraction. Results of biocompatibility test showed no sign of cytotoxicity and cells were found to be attached to the pore walls offered by the conduits. Conclusion: According to the results, nano bioglass conduits could be a good candidate for peripheral nerve regeneration. (Sci J Hamadan Univ Med Sci 2014; 21 (2:152-160

Design Research of TIANDITU (Map Worl)-Based Geographic Information System for Travelling Service

Science.gov (United States)

Zhang, J.; Zhang, H.; Wang, C.

2014-04-01

TIANDITU (Map World) is the public version of the National Platform for Common Geospatial Information Service, and the travelling channel is TIANDITU-based geographic information platform for travelling service. With the development of tourism, traditional ways for providing travelling information cannot meet the needs of travelers. As such, the travelling channel of TIANDITU focuses on providing travel information abundantly and precisely, which integrated the geographic information data of TIANDITU Version 2.0 and the authoritative information resources from China National Tourism Administration. Furthermore, spatial positioning, category and information query of various travelling information were offered for the public in the travelling channel. This research mainly involves three important parts: the system design, key technologies of the system design and application examples. Firstly, this paper introduced the design of TIANDITU-based geographic information system for travelling service, and the general and database design were described in detail. The designs for general, database and travelling service above should consider lots of factors which illustrated in the paper in order to guarantee the efficient service. The process of system construction, the content of geographic information for travelling and system functions of geographic information for travelling are also proposed via diagram in this part. Then several key technologies were discussed, including the travelling information integration for main node and among nodes, general architecture design and management system for travelling channel, web portals and system interface. From the perspective of main technologies, this part describes how TIANDITU travelling channel can realize various functions and reach the requirements from different users. Finally, three application examples about travelling information query were listed shortly. The functions and search results are shown clearly in this

The Foundation Role for Theories of Agency in Understanding Information Systems Design

Directory of Open Access Journals (Sweden)

Robert Johnston

2002-11-01

Full Text Available In this paper we argue that theories of agency form a foundation upon which we can build a deeper understanding of information systems design. We do so by firstly recognising that information systems are part of purposeful sociotechnical systems and that consequently theories of agency may help in understanding them. We then present two alternative theories of agency (deliberative and situational, mainly drawn from the robotics and artificial intelligence disciplines, and in doing so, we note that existing information system design methods and ontological studies of those methods implicitly adhere to the deliberative theory of agency. We also note that while there are advantages in specific circumstances from utilising the situated theory of agency in designing complex systems, because of their differing ontological commitments, such systems would be difficult to analyse and evaluate using ontologies currently used in information systems. We then provide evidence that such situational information systems can indeed exist, by giving a specific example (the Kanban system, which has emerged from manufacturing practice. We conclude that information systems are likely to benefit from creating design approaches supporting the production of situational systems.

The Application of Use Case Modeling in Designing Medical Imaging Information Systems

International Nuclear Information System (INIS)

Safdari, Reza; Farzi, Jebraeil; Ghazisaeidi, Marjan; Mirzaee, Mahboobeh; Goodini, Azadeh

2013-01-01

Introduction. The essay at hand is aimed at examining the application of use case modeling in analyzing and designing information systems to support Medical Imaging services. Methods. The application of use case modeling in analyzing and designing health information systems was examined using electronic databases (Pubmed, Google scholar) resources and the characteristics of the modeling system and its effect on the development and design of the health information systems were analyzed. Results. Analyzing the subject indicated that Provident modeling of health information systems should provide for quick access to many health data resources in a way that patients' data can be used in order to expand distant services and comprehensive Medical Imaging advices. Also these experiences show that progress in the infrastructure development stages through gradual and repeated evolution process of user requirements is stronger and this can lead to a decline in the cycle of requirements engineering process in the design of Medical Imaging information systems. Conclusion. Use case modeling approach can be effective in directing the problems of health and Medical Imaging information systems towards understanding, focusing on the start and analysis, better planning, repetition, and control

Risk-informed design guidance for future reactor systems

International Nuclear Information System (INIS)

Delaney, Michael J.; Apostolakis, George E.; Driscoll, Michael J.

2005-01-01

Future reactor designs face an uncertain regulatory environment. It is anticipated that there will be some level of probabilistic insights in the regulations and supporting regulatory documents for Generation-IV nuclear reactors. Central to current regulations are design basis accidents (DBAs) and the general design criteria (GDC), which were established before probabilistic risk assessments (PRAs) were developed. These regulations implement a structuralist approach to safety through traditional defense in depth and large safety margins. In a rationalist approach to safety, accident frequencies are quantified and protective measures are introduced to make these frequencies acceptably low. Both approaches have advantages and disadvantages and future reactor design and licensing processes will have to implement a hybrid approach. This paper presents an iterative four-step risk-informed methodology to guide the design of future-reactor systems using a gas-cooled fast reactor emergency core cooling system as an example. This methodology helps designers to analyze alternative designs under potential risk-informed regulations and to anticipate design justifications the regulator may require during the licensing process. The analysis demonstrated the importance of common-cause failures and the need for guidance on how to change the quantitative impact of these potential failures on the frequency of accident sequences as the design changes. Deliberation is an important part of the four-step methodology because it supplements the quantitative results by allowing the inclusion in the design choice of elements such as best design practices and ease of online maintenance, which usually cannot be quantified. The case study showed that, in some instances, the structuralist and the rationalist approaches were inconsistent. In particular, GDC 35 treats the double-ended break of the largest pipe in the reactor coolant system with concurrent loss of offsite power and a single

Design and Establishment of Quality Model of Fundamental Geographic Information Database

Science.gov (United States)

Ma, W.; Zhang, J.; Zhao, Y.; Zhang, P.; Dang, Y.; Zhao, T.

2018-04-01

In order to make the quality evaluation for the Fundamental Geographic Information Databases(FGIDB) more comprehensive, objective and accurate, this paper studies and establishes a quality model of FGIDB, which formed by the standardization of database construction and quality control, the conformity of data set quality and the functionality of database management system, and also designs the overall principles, contents and methods of the quality evaluation for FGIDB, providing the basis and reference for carry out quality control and quality evaluation for FGIDB. This paper designs the quality elements, evaluation items and properties of the Fundamental Geographic Information Database gradually based on the quality model framework. Connected organically, these quality elements and evaluation items constitute the quality model of the Fundamental Geographic Information Database. This model is the foundation for the quality demand stipulation and quality evaluation of the Fundamental Geographic Information Database, and is of great significance on the quality assurance in the design and development stage, the demand formulation in the testing evaluation stage, and the standard system construction for quality evaluation technology of the Fundamental Geographic Information Database.

The evolution of concepts of vestibular peripheral information processing: toward the dynamic, adaptive, parallel processing macular model

Science.gov (United States)

Ross, Muriel D.

2003-01-01

In a letter to Robert Hooke, written on 5 February, 1675, Isaac Newton wrote "If I have seen further than certain other men it is by standing upon the shoulders of giants." In his context, Newton was referring to the work of Galileo and Kepler, who preceded him. However, every field has its own giants, those men and women who went before us and, often with few tools at their disposal, uncovered the facts that enabled later researchers to advance knowledge in a particular area. This review traces the history of the evolution of views from early giants in the field of vestibular research to modern concepts of vestibular organ organization and function. Emphasis will be placed on the mammalian maculae as peripheral processors of linear accelerations acting on the head. This review shows that early, correct findings were sometimes unfortunately disregarded, impeding later investigations into the structure and function of the vestibular organs. The central themes are that the macular organs are highly complex, dynamic, adaptive, distributed parallel processors of information, and that historical references can help us to understand our own place in advancing knowledge about their complicated structure and functions.

Current Total Knee Designs: Does Baseplate Roughness or Locking Mechanism Design Affect Polyethylene Backside Wear?

Science.gov (United States)

Sisko, Zachary W; Teeter, Matthew G; Lanting, Brent A; Howard, James L; McCalden, Richard W; Naudie, Douglas D; MacDonald, Steven J; Vasarhelyi, Edward M

2017-12-01

Tibial baseplate roughness and polyethylene-insert micromotion resulting from locking-mechanism loosening can lead to polyethylene backside wear in TKAs. However, many retrieval studies examining these variables have evaluated only older TKA implant designs. We used implant-retrieval analysis to examine if there were differences in: (1) backside damage scores, (2) backside damage modes, and (3) backside linear wear rates in five TKA implant designs owing to differing baseplate surface roughness and locking mechanisms. Additionally, we examined if (4) patient demographics influence backside damage and wear. Five TKA implant models (four modern and one historical design) were selected with different tibial baseplate and/or locking mechanism designs. Six tibial inserts retrieved at the time of revision from each TKA model were matched for time in vivo, age of the patient at TKA revision, BMI, sex, revision number, and revision reason. Each insert backside was analyzed for: (1) visual total damage score and (2) individual visual damage modes, both by two observers and with an intraclass correlation coefficient of 0.66 (95% CI, 0.39-0.92), and (3) linear wear rate measured by micro-CT. Median primary outcomes were compared among the five designs. For our given sample size among five groups we could detect with 80% power a 10-point difference in damage score and an 0.11-mm per year difference in wear rate. The polished tibial design with a partial peripheral capture locking mechanism and anterior constraint showed a lower total damage score compared with the nonpolished tibial design with only a complete peripheral-rim locking mechanism (median, 12.5; range, 9.5-18.0; 95% CI, 9.58-16.42 versus median, 22.3; range, 15.5-27.0; 95% CI, 17.5-26.5; p = 0.019). The polished baseplate with a tongue-in-groove locking mechanism showed more abrasions than the nonpolished baseplate with a peripheral-rim capture and antirotational island (median, 7.25; range, 0.5-8.0; 95% CI, 2

Design principles for achieving integrated healthcare information systems.

Science.gov (United States)

Jensen, Tina Blegind

2013-03-01

Achieving integrated healthcare information systems has become a common goal for many countries in their pursuit of obtaining coordinated and comprehensive healthcare services. This article focuses on how a small local project termed 'Standardized pull of patient data' expanded and is now used on a large scale providing a majority of hospitals, general practitioners and citizens across Denmark with the possibility of accessing healthcare data from different electronic patient record systems and other systems. I build on design theory for information infrastructures, as presented by Hanseth and Lyytinen, to examine the design principles that facilitated this smallscale project to expand and become widespread. As a result of my findings, I outline three lessons learned that emphasize: (i) principles of flexibility, (ii) expansion from the installed base through modular strategies and (iii) identification of key healthcare actors to provide them with immediate benefits.

On being peripheral: Effects of identity insecurity on personal and collective self-esteem

NARCIS (Netherlands)

Jetten, J.; Branscombe, N.R.; Spears, R.

2002-01-01

We examined collective self-esteem and personal self-esteem as a function of anticipated changes in one's prototypicality within a valued ingroup. In Study 1 (N = 80), all participants received information that they were currently peripheral group members. Expectations for the future were then

On being peripheral : effects of identity insecurity on personal and collective self-esteem

NARCIS (Netherlands)

Jetten, J; Branscombe, NR; Spears, R

2002-01-01

We examined collective self-esteem and personal self-esteem as a function of anticipated changes in one's prototypicality, within a valued ingroup. In Study, 1 (N=80), all participants received information that they, it-ere currently peripheral group members. Expectations for the future were then

Information model design health service childhood cancer for parents and caregivers

Science.gov (United States)

Ramli, Syazwani; Muda, Zurina

2015-05-01

Most Malaysians do not realize that they are suffer from a chronic disease until the disease is confirmed to be at a critical stage. This is because lack of awareness among Malaysians about a chronic disease especially in a childhood cancer. Based on report of the National Cancer Council (MAKNA),11 million adults and children suffered with cancer and 6 million of them die in a worldwide. Lack of public exposure to this disease leads to health problems to their children. Information model design health service childhood cancer for p arents and caregivers using an android application medium can be used by a doctor to deliver an information of cancer to the parents and caregivers. The development of this information model design health service childhood cancer for parents and caregivers are using an integration of health promotion theory, spiral model and lean model to form a new model that can be used as a model design content of health service. The method using in this study are by an interview technique and questionnaires along the study was conducted. Hopefully the production of this information model design health service childhood cancer for parents and caregivers using an android apps as a medium can help parents, caregivers and public to know more about information of childhood cancer and at the same time can gain an awareness among them and this app also can be used as a medium for doctors to deliver an information to the parents and caregivers.

Data Visualization and Infographics In Visual Communication Design Education at The Age of Information

OpenAIRE

Banu Inanc Uyan Dur

2014-01-01

Scientific and technologic developments in the last century facilitate people’s lives while also causing them to face more information. Information design has become much more important as a result of the chaos created by the unprocessed heap of data and information traffic. Therefore, people need designed information like infographics and data visualisation today. Design of information, which is among the most significant requirements of our age, has become a subject which needs to be dealt ...

Completion of the Heysham 2 peripheral manipulator

International Nuclear Information System (INIS)

Shipp, R.; Ewen, R.O.

1996-01-01

The in-service inspection strategy for the AGR power station at Heysham 2 envisaged a suite of five manipulators to be used for inserting TRIUMPH television cameras into the reactor vessel. Prior to power raising, four of the five had been successfully commissioned and have been in regular use during the subsequent statutory outages. The final device, the Peripheral Manipulator (PM), was eventually completed prior to the 1994 outage and has been successfully deployed on reactor for both the 1994 and 1995 outages. The paper describes the design of the manipulator, its operation and scope of use in the Heysham 2 reactors. (Author)

Contested collaboration: A descriptive model of intergroup communication in information system design

DEFF Research Database (Denmark)

Sonnenwald, D.H.

1995-01-01

. The model describes design phases, roles, themes, and intergroup communication networks as they evolve throughout the design process and characterizes design as a process of ''contested collaboration.'' It is a first step towards a predictive design model that suggests strategies which may help participants......Many information system design situations today include users, designers, and developers who, with their own unique group and individual perspectives, need to interact so that they can come to a working understanding of how the information system being developed will coexist with and ideally...... support patterns of work activities, social groups, and personal beliefs. In these situations, design is fundamentally an interactive process that requires communication among users, designers, and developers. However, communication among these groups is often difficult although of paramount importance...

Design of the Hospital Integrated Information Management System Based on Cloud Platform.

Science.gov (United States)

Aijing, L; Jin, Y

2015-12-01

At present, the outdated information management style cannot meet the needs of hospital management, and has become the bottleneck of hospital's management and development. In order to improve the integrated management of information, hospitals have increased their investment in integrated information management systems. On account of the lack of reasonable and scientific design, some hospital integrated information management systems have common problems, such as unfriendly interface, poor portability and maintainability, low security and efficiency, lack of interactivity and information sharing. To solve the problem, this paper carries out the research and design of a hospital information management system based on cloud platform, which can realize the optimized integration of hospital information resources and save money.

Methods and tools in user-centred design for information technology

CERN Document Server

Galer, Margaret; Ziegler, J; Galer, Mark

1992-01-01

This book is concerned with the development of human factorsinputs to software design. The aim is to create products whichmatch the requirements and characteristics of users and whichoffer usable user interfaces. The HUFIT project - Human Factorsin Information Technology - was carried out within the EuropeanStrategic Programme for Research and Development in InformationTechnology (ESPRIT) with the objective of enhancing the qualityof software design within the European Community. The variety ofactivities undertaken to achieve this goal are reflected in thisbook. It describes human factors know

Synovial sarcoma mimicking benign peripheral nerve sheath tumor

Energy Technology Data Exchange (ETDEWEB)

Larque, Ana B.; Nielsen, G.P.; Chebib, Ivan [Massachusetts General Hospital and Harvard Medical School, Department of Pathology, Boston, MA (United States); Bredella, Miriam A. [Massachusetts General Hospital and Harvard Medical School, Department of Radiology, Boston, MA (United States)

2017-11-15

To assess the radiographic and clinicopathologic features of synovial sarcoma of the nerve that were clinically or radiologically interpreted as benign peripheral nerve sheath tumor. Five patients with synovial sarcoma arising from the peripheral nerve and interpreted clinically and radiologically as peripheral nerve sheath tumors were identified. Clinicopathologic and imaging features were evaluated. There were three females and two males, ranging in age from 28 to 50 (mean 35.8) years. Most patients (4/5) complained of a mass, discomfort or pain. MR images demonstrated a heterogeneous, enhancing, soft tissue mass contiguous with the neurovascular bundle. On histologic examination, most tumors were monophasic synovial sarcoma (4/5). At the time of surgery, all tumors were noted to arise along or within a peripheral nerve. All patients were alive with no evidence of disease with median follow-up of 44 (range 32-237) months. For comparison, approximately 775 benign peripheral nerve sheath tumors of the extremities were identified during the same time period. Primary synovial sarcoma of the nerve can mimic peripheral nerve sheath tumors clinically and on imaging and should be included in the differential diagnosis for tumors arising from peripheral nerves. (orig.)

Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors

DEFF Research Database (Denmark)

Boyle, Jenny L; Haupt, Helen M; Stern, Jere B

2002-01-01

of tyrosinase expression in the differential diagnosis of melanoma, desmoplastic melanoma, and peripheral nerve sheath tumors. DESIGN: Immunoreactivity for tyrosinase, HMB-45 (anti-gp100 protein), S100 protein, CD34, and vimentin was studied in 70 tumors, including 15 melanomas (5 desmoplastic, 4 amelanotic, 6...... at 121 degrees C. RESULTS: All melanomas demonstrated positive immunostaining for tyrosinase, HMB-45, and S100 protein. Immunoreactivity for HMB-45 was generally stronger than that for tyrosinase in amelanotic lesions and significantly stronger in 1 of the desmoplastic lesions. The 4 pigmented...... neurofibromas were focally positive for tyrosinase, but did not stain for HMB-45. The pigmented schwannoma was focally positive for both tyrosinase and HMB-45. The malignant peripheral nerve sheath tumors, dermatofibrosarcoma protuberans, and dermatofibromas were nonreactive for tyrosinase and HMB-45...

Informed Design to Robotic Production Systems; Developing Robotic 3D Printing System for Informed Material Deposition

NARCIS (Netherlands)

Mostafavi, S.; Bier, H.; Bodea, S.; Anton, A.M.

2015-01-01

This paper discusses the development of an informed Design-to-Robotic-Production (D2RP) system for additive manufacturing to achieve performative porosity in architecture at various scales. An extended series of experiments on materiality, fabrication and robotics were designed and carried out

Information Design for Synchronization and Co-ordination of Modern, Complex, Multi-National Operations

Science.gov (United States)

2011-06-01

1 16th ICCRTS Information design for synchronization and co-ordination of modern, complex, multi- national operations “Collective C2 in...REPORT DATE JUN 2011 2. REPORT TYPE 3. DATES COVERED 00-00-2011 to 00-00-2011 4. TITLE AND SUBTITLE Information design for synchronization and co...at 11th ICCRTS) who emphasise that information needs to be designed, not merely found or catalogued, to achieve synchronizations and co-ordinations

Peripheral refractive correction and automated perimetric profiles.

Science.gov (United States)

Wild, J M; Wood, J M; Crews, S J

1988-06-01

The effect of peripheral refractive error correction on the automated perimetric sensitivity profile was investigated on a sample of 10 clinically normal, experienced observers. Peripheral refractive error was determined at eccentricities of 0 degree, 20 degrees and 40 degrees along the temporal meridian of the right eye using the Canon Autoref R-1, an infra-red automated refractor, under the parametric conditions of the Octopus automated perimeter. Perimetric sensitivity was then undertaken at these eccentricities (stimulus sizes 0 and III) with and without the appropriate peripheral refractive correction using the Octopus 201 automated perimeter. Within the measurement limits of the experimental procedures employed, perimetric sensitivity was not influenced by peripheral refractive correction.

Project HealthDesign: enhancing action through information.

Science.gov (United States)

Brennan, Patricia Flatley; Casper, Gail; Downs, Stephen; Aulahk, Veenu

2009-01-01

Project HealthDesign is a country-wide initiative in the United States designed to stimulate innovation in personal health records (PHRs). Nine grantee teams engaged in an 18-month long design and prototyping process. Two teams addressed the needs of children and adolescents; three created novel approaches to help adults prevent or manage metabolic syndrome; three groups employed interface innovations to assist patients with chronic care management and one team devised a novel calendaring system to assist patients undergoing complex medical/surgical treatments to integrate care processes into their daily lives. These projects not only included development and testing of novel personal health records applications, but also served as the starting point to specify and implement a common technical core platform. The project advanced PHR development in two key ways: intensive user-centered design and a development architecture that separates applications of PHRs from the infrastructure that supports them. The initiative also allowed systematic investigation of significant ethical, legal and social issues, including how privacy considerations are changed when information technology innovations are used in the home and the rebalancing of the authority structure of health care decision making when patient-centered approaches guide the design of PHRs.

Design of a Business-to-Government Information Sharing Architecture Using Business Rules

NARCIS (Netherlands)

Van Engelenburg, S.H.; Janssen, M.F.W.H.A.; Klievink, A.J.

2016-01-01

Information sharing between businesses and government agencies is of vital importance, yet business are often reluctant to share information, e.g. as it might be misused. Taking this into account is however often overlooked in the design of software architectures. In this research we apply a design

Discussion on AI Technology in Information Library Design

OpenAIRE

日比野, 省三; Shozo, HIBINO; 中京大学社会学部

1987-01-01

This paper deals with the discussion on the importance of AI (Artificial Intelligence) Technology in planning and designing a library information system in the near future. First of all, the history of Library and Information Science is reviewed and it is identified that the key technology in the future library will be AI as a mega-trend. After reviewing the concepts of AI technology, a model of a Knowledge-Base system is discussed as a case study, using micro-PROLOG.

Development of risk-informed assessment (RIA) design methodology

International Nuclear Information System (INIS)

Ji, S. K.; Park, S. J.; Park, B. R.; Kim, M. R.; Choi, C. J.

2001-01-01

It has been assessed that the capital cost for future nuclear power plants needs to be reduced on the order of 35% to 40% for Advanced Light Water Reactors such as KNGR and System 80+. Such reduction in the capital cost will require a fundamental re-evaluation of the industry standards and regulatory basis under which nuclear plants are designed and licensed. The objective of this study is to develop the risk-informed assessment (RIA) design methodology for future nuclear power plants. In order to meet this objective, the design simplification method is developed and RIA design methodology exercised for conceptual system. For the methodology verification, simplified conceptual ECCS and feedwater system are developed, then LOCA sensitivity analyses and agressive secondary cooldown analyses for these systems are performed. In addition, the probability safety assessment (PSA) model for LOCA is developed and the validation of RIA design methodology is demonstrated

Randomized controlled trial to evaluate the effect of canola oil on blood vessel function in peripheral arterial disease: rationale and design of the Canola-PAD Study

Directory of Open Access Journals (Sweden)

Enns JE

2014-10-01

Full Text Available Jennifer E Enns,1,2 Peter Zahradka,1–3 Randolph P Guzman,4,5 Alanna Baldwin,1 Brendon Foot,1 Carla G Taylor1–31Canadian Centre for Agri-Food Research in Health and Medicine, St Boniface Research Centre, Winnipeg, Canada; 2Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada; 3Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada; 4IH Asper Clinical Research Institute, St Boniface Hospital, Winnipeg, Canada; 5Section of Vascular Surgery, Department of Surgery, St Boniface Hospital, Winnipeg, CanadaBackground: Individuals with peripheral arterial disease (PAD are at high risk for cardiac events due to atherosclerosis. Dietary fatty acid composition has been shown to modulate blood vessel properties, but whether a diet enriched in conventional canola oil can improve clinical endpoints in PAD is not known.Purpose: To describe the rationale and design of a clinical trial testing the effect of canola oil consumption on vascular function and cardiovascular risk factors in an 8-week dietary intervention in individuals with PAD.Methods: The Canola-PAD Study was a single center, prospective, double-blind, randomized controlled trial in 50 patients over 40 years old with PAD. Participants were randomized into two groups and consumed food items containing either conventional canola oil (25 g/day or an oil mixture representing the Western diet (25 g/day for 8 weeks as part of their usual diet. The primary outcome was vascular function (ankle-brachial index, arterial stiffness, endothelial dysfunction, walking capacity, and cognitive function. Secondary measurements included anthropometrics, serum lipid profile and fatty acid composition, markers of inflammation and glycemic control, and serum metabolite profile.Discussion: The Canola-PAD Study uses an innovative and noninvasive approach to evaluate the effect of canola oil on clinically relevant outcomes in individuals with PAD, including

Using a 'value-added' approach for contextual design of geographic information.

Science.gov (United States)

May, Andrew J

2013-11-01

The aim of this article is to demonstrate how a 'value-added' approach can be used for user-centred design of geographic information. An information science perspective was used, with value being the difference in outcomes arising from alternative information sets. Sixteen drivers navigated a complex, unfamiliar urban route, using visual and verbal instructions representing the distance-to-turn and junction layout information presented by typical satellite navigation systems. Data measuring driving errors, navigation errors and driver confidence were collected throughout the trial. The results show how driver performance varied considerably according to the geographic context at specific locations, and that there are specific opportunities to add value with enhanced geographical information. The conclusions are that a value-added approach facilitates a more explicit focus on 'desired' (and feasible) levels of end user performance with different information sets, and is a potentially effective approach to user-centred design of geographic information. Copyright © 2012 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Design of safeguards information treatment system at the facility level

Energy Technology Data Exchange (ETDEWEB)

Song, Dae Yong; Lee, Byung Doo; Kwack, Eun Ho; Choi, Young Myong

2001-05-01

We are developing Safeguards Information Treatment System at the facility level(SITS) to manage synthetically safeguards information and to implement efficiently the obligations under the Korea-IAEA Safeguards Agreement, bilateral agreements with other countries and domestic law. In this report, we described the contents of the detailed design of SITS such as database, I/O layout and program. In the present, we are implementing the SITS based on the contents of the design of SITS, and then we plan to provide the system for the facilities after we finish implementing and testing the system.

Design of safeguards information treatment system at the facility level

International Nuclear Information System (INIS)

Song, Dae Yong; Lee, Byung Doo; Kwack, Eun Ho; Choi, Young Myong

2001-05-01

We are developing Safeguards Information Treatment System at the facility level(SITS) to manage synthetically safeguards information and to implement efficiently the obligations under the Korea-IAEA Safeguards Agreement, bilateral agreements with other countries and domestic law. In this report, we described the contents of the detailed design of SITS such as database, I/O layout and program. In the present, we are implementing the SITS based on the contents of the design of SITS, and then we plan to provide the system for the facilities after we finish implementing and testing the system

Managing satisfaction in cultural events: Exploring the role of core and peripheral product

Directory of Open Access Journals (Sweden)

Manuel Cuadrado-García

2017-01-01

Full Text Available This paper measures satisfaction with a cultural event following an innovative approach by differentiating between the art form itself (core product and the main attributes connected with it (augmented product. 122 individuals (out of 820 visitors were interviewed on their overall satisfaction and on different aspects of their visiting experience. Multivariate techniques such as ANOVA, principal component factor analysis and regression were performed to analyse the data. Results show the importance of both the core and the peripheral product in measuring satisfaction with a cultural event, thereby highlighting their importance for product management in the arts. The small sample, the specificity of the data and the bias of the distribution have prevented further multivariate analysis. A future area of research is on antecedents to customer satisfaction in the arts field. The contribution of peripheral elements to satisfaction should not be underestimated. Despite artists’ freedom to produce the work of art, a series of peripheral elements should be designed along with the other variables of the marketing mix in order to adapt and differentiate the artistic production to the target audience. This paper contributes a different perspective to measuring satisfaction in the arts context while considering the role of the core product and its peripherals.

Transplantation of olfactory ensheathing cells as adjunct cell therapy for peripheral nerve injury.

Science.gov (United States)

Radtke, Christine; Wewetzer, Konstantin; Reimers, Kerstin; Vogt, Peter M

2011-01-01

Traumatic events, such as work place trauma or motor vehicle accident violence, result in a significant number of severe peripheral nerve lesions, including nerve crush and nerve disruption defects. Transplantation of myelin-forming cells, such as Schwann cells (SCs) or olfactory ensheathing cells (OECs), may be beneficial to the regenerative process because the applied cells could mediate neurotrophic and neuroprotective effects by secretion of chemokines. Moreover, myelin-forming cells are capable of bridging the repair site by establishing an environment permissive to axonal regeneration. The cell types that are subject to intense investigation include SCs and OECs either derived from the olfactory bulb or the olfactory mucosa, stromal cells from bone marrow (mesenchymal stem cells, MSCs), and adipose tissue-derived cells. OECs reside in the peripheral and central nervous system and have been suggested to display unique regenerative properties. However, so far OECs were mainly used in experimental studies to foster central regeneration and it was not until recently that their regeneration-promoting activity for the peripheral nervous system was recognized. In the present review, we summarize recent experimental evidence regarding the regenerative effects of OECs applied to the peripheral nervous system that may be relevant to design novel autologous cell transplantation therapies. © 2011 Cognizant Comm. Corp.

Critical Theory as a foundation for Pragmatic Information Systems Design

OpenAIRE

Gerald Benoît

2001-01-01

This paper considers how designers of information systems and end-user perspectives, communication models and linguistic behaviors differ. A critique of these differences is made by applying Habermas's communicative action principles. An empirical study of human-human information seeking, based on those principles, indicates which behaviors are predictors of successful interactions and so are candidate behaviors may be integrated into computerized information systems.

Evaluation of Information Requirements of Reliability Methods in Engineering Design

DEFF Research Database (Denmark)

Marini, Vinicius Kaster; Restrepo-Giraldo, John Dairo; Ahmed-Kristensen, Saeema

2010-01-01

This paper aims to characterize the information needed to perform methods for robustness and reliability, and verify their applicability to early design stages. Several methods were evaluated on their support to synthesis in engineering design. Of those methods, FMEA, FTA and HAZOP were selected...

Validation and Design Science Research in Information Systems

NARCIS (Netherlands)

Sol, H G; Gonzalez, Rafael A.; Mora, Manuel

2012-01-01

Validation within design science research in Information Systems (DSRIS) is much debated. The relationship of validation to artifact evaluation is still not clear. This chapter aims at elucidating several components of DSRIS in relation to validation. The role of theory and theorizing are an

Information system design for demand-driven supply networks

OpenAIRE

Selk, Bernhard

2004-01-01

Information system design for demand-driven supply networks : integrating CRM & SCM / B. Selk, K. Turowski, C. Winnewisser. - In: EIS : Fourth International ICSC Symposium on Engineering of Intelligent Systems, EIS 2004. [Elektronische Ressource]. - Millet, Alberta : ICSC Interdisciplinary Research Canada, 2004. - 8 S. auf CD-ROM

Peripheral facial weakness (Bell's palsy).

Science.gov (United States)

Basić-Kes, Vanja; Dobrota, Vesna Dermanović; Cesarik, Marijan; Matovina, Lucija Zadro; Madzar, Zrinko; Zavoreo, Iris; Demarin, Vida

2013-06-01

Peripheral facial weakness is a facial nerve damage that results in muscle weakness on one side of the face. It may be idiopathic (Bell's palsy) or may have a detectable cause. Almost 80% of peripheral facial weakness cases are primary and the rest of them are secondary. The most frequent causes of secondary peripheral facial weakness are systemic viral infections, trauma, surgery, diabetes, local infections, tumor, immune disorders, drugs, degenerative diseases of the central nervous system, etc. The diagnosis relies upon the presence of typical signs and symptoms, blood chemistry tests, cerebrospinal fluid investigations, nerve conduction studies and neuroimaging methods (cerebral MRI, x-ray of the skull and mastoid). Treatment of secondary peripheral facial weakness is based on therapy for the underlying disorder, unlike the treatment of Bell's palsy that is controversial due to the lack of large, randomized, controlled, prospective studies. There are some indications that steroids or antiviral agents are beneficial but there are also studies that show no beneficial effect. Additional treatments include eye protection, physiotherapy, acupuncture, botulinum toxin, or surgery. Bell's palsy has a benign prognosis with complete recovery in about 80% of patients, 15% experience some mode of permanent nerve damage and severe consequences remain in 5% of patients.

CT characteristics of peripheral organizing pneumonia

International Nuclear Information System (INIS)

Yang, Seong Oh; Choi, Chul Soon; Kim, Myung Joon; Lee, Kyung Soo; Choi, Hyung Sik; Jun, Young Hwan; Park, Yong Koo

1988-01-01

Diagnostic dilemma of persistent mass-forming parenchymal opacity in the lung periphery occurs occasionally in the realm of diagnostic radiology. Until recently, literature on the role of computed tomography in peripheral organizing pneumonia, which is difficult to differentiate from malignancy, has little been published. We experienced one case of pathologically proven organizing pneumonia diagnosed preoperatively by chest CT. When it comes to solitary peripheral mass density in the lung, we think that CT can be proved useful in the diagnosis of benign organizing pneumonia by showing regular and smoothly corrugate margin, peripheral contrast enhancement with inner low density, and air-trapping by intervening normal lung parenchyma.

Laser peripheral iridoplasty for angle-closure.

Science.gov (United States)

Ng, Wai Siene; Ang, Ghee Soon; Azuara-Blanco, Augusto

2012-02-15

Angle-closure glaucoma is a leading cause of irreversible blindness in the world. Treatment is aimed at opening the anterior chamber angle and lowering the IOP with medical and/or surgical treatment (e.g. trabeculectomy, lens extraction). Laser iridotomy works by eliminating pupillary block and widens the anterior chamber angle in the majority of patients. When laser iridotomy fails to open the anterior chamber angle, laser iridoplasty may be recommended as one of the options in current standard treatment for angle-closure. Laser peripheral iridoplasty works by shrinking and pulling the peripheral iris tissue away from the trabecular meshwork. Laser peripheral iridoplasty can be used for crisis of acute angle-closure and also in non-acute situations.   To assess the effectiveness of laser peripheral iridoplasty in the treatment of narrow angles (i.e. primary angle-closure suspect), primary angle-closure (PAC) or primary angle-closure glaucoma (PACG) in non-acute situations when compared with any other intervention. In this review, angle-closure will refer to patients with narrow angles (PACs), PAC and PACG. We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library 2011, Issue 12), MEDLINE (January 1950 to January 2012), EMBASE (January 1980 to January 2012), Latin American and Caribbean Literature on Health Sciences (LILACS) (January 1982 to January 2012), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (www.clinicaltrials.gov) and the WHO International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). There were no date or language restrictions in the electronic searches for trials. The electronic databases were last searched on 5 January 2012. We included only randomised controlled trials (RCTs) in this review. Patients with narrow angles, PAC or PACG were eligible. We excluded studies that included only patients with acute presentations

[Peripheral retinal degenerations--treatment recommendations].

Science.gov (United States)

Joussen, A M; Kirchhof, B

2004-10-01

This report reviews the clinical appearance of degenerative diseases of the peripheral retina in relationship to the risk of developing a rhegmatogenous retinal detachment. We present recommendations for preventive treatment in eyes at increased risk of developing retinal detachment. Retinal degenerations are common lesions involving the peripheral retina but most of them are clinically insignificant. Lattice degeneration, degenerative retinoschisis, cystic retinal tufts, and very rarely zonular traction tufts can result in rhegmatogenous retinal detachment. Therefore, these lesions have been considered for prophylactic treatment; however, adequate studies have not been performed to date. Most of the peripheral retinal degenerations may not require treatment except in rare, high-risk situations. According to current knowledge there is no higher incidence of secondary pucker or other side effects after laser coagulation. Therefore, generous laser indication is recommended if risk factors apply.

Information technology made simple

CERN Document Server

Carter, Roger

1991-01-01

Information Technology: Made Simple covers the full range of information technology topics, including more traditional subjects such as programming languages, data processing, and systems analysis. The book discusses information revolution, including topics about microchips, information processing operations, analog and digital systems, information processing system, and systems analysis. The text also describes computers, computer hardware, microprocessors, and microcomputers. The peripheral devices connected to the central processing unit; the main types of system software; application soft

Regulation of peripheral inflammation by spinal p38 MAP kinase in rats.

Directory of Open Access Journals (Sweden)

David L Boyle

2006-09-01

Full Text Available Somatic afferent input to the spinal cord from a peripheral inflammatory site can modulate the peripheral response. However, the intracellular signaling mechanisms in the spinal cord that regulate this linkage have not been defined. Previous studies suggest spinal cord p38 mitogen-activated protein (MAP kinase and cytokines participate in nociceptive behavior. We therefore determined whether these pathways also regulate peripheral inflammation in rat adjuvant arthritis, which is a model of rheumatoid arthritis.Selective blockade of spinal cord p38 MAP kinase by administering the p38 inhibitor SB203580 via intrathecal (IT catheters in rats with adjuvant arthritis markedly suppressed paw swelling, inhibited synovial inflammation, and decreased radiographic evidence of joint destruction. The same dose of SB203580 delivered systemically had no effect, indicating that the effect was mediated by local concentrations in the neural compartment. Evaluation of articular gene expression by quantitative real-time PCR showed that spinal p38 inhibition markedly decreased synovial interleukin-1 and -6 and matrix metalloproteinase (MMP3 gene expression. Activation of p38 required tumor necrosis factor alpha (TNFalpha in the nervous system because IT etanercept (a TNF inhibitor given during adjuvant arthritis blocked spinal p38 phosphorylation and reduced clinical signs of adjuvant arthritis.These data suggest that peripheral inflammation is sensed by the central nervous system (CNS, which subsequently activates stress-induced kinases in the spinal cord via a TNFalpha-dependent mechanism. Intracellular p38 MAP kinase signaling processes this information and profoundly modulates somatic inflammatory responses. Characterization of this mechanism could have clinical and basic research implications by supporting development of new treatments for arthritis and clarifying how the CNS regulates peripheral immune responses.

Structural optimization for materially informed design to robotic production processes

NARCIS (Netherlands)

Bier, H.H.; Mostafavi, S.

2015-01-01

Hyperbody’s materially informed Design-to-Robotic-Production (D2RP) processes for additive and subtractive manufacturing aim to achieve performative porosity in architecture at various scales. An extended series of D2RP experiments aiming to produce prototypes at 1:1 scale wherein design materiality

Proxemic Transitions: Designing Shape-Changing Furniture for Informal Meetings

DEFF Research Database (Denmark)

Grønbæk, Jens Emil; Korsgaard, Henrik; Petersen, Marianne Graves

2017-01-01

Shape-changing interfaces is an emerging field in HCI that explores the qualities of physically dynamic artifacts. At furniture-scale such dynamic artifacts have the potential of changing the ways we collaborate and engage with spaces. In- formed by theories of proxemics, empirical studies...... of informal meetings and design work with shape-changing furniture, we develop the notion of proxemic transitions. We present three design aspects of proxemic transitions: transition speed, step- wise reconfiguration, and situational flexibility. The design aspects focus on how to balance between physical...... between a table and a board surface. These contributions outline important aspects to consider when designing shape-changing furniture....

Natural resource management information systems: a guide to design

Energy Technology Data Exchange (ETDEWEB)

Tschanz, J.F.; Kennedy, A.S.

1975-07-01

Resource management requires the timely supply of intelligible, concise information to facilitate the variety of decisions needed. A distinctive component of information useful in resource management is its spatial content. The first portion of this guidebook sketches the resource management needs for spatial information, indicating not only the variety of resource management contexts, but also the variety of information/data handling approaches that exist. Within this diversity, common structural characteristics for all spatial information/data handling can be perceived, and the remainder of the guidebook outlines the general structure of a resource management information system and a process for designing such a system. Three basic elements of the information system are data base management, data retrieval and processing, and system support. Equally important are the interfaces through which the system is linked to its community of users, data supply, and available information system technology.

Risk-informed design of IRIS using a level-1 probabilistic risk assessment from its conceptual design phase

International Nuclear Information System (INIS)

Mizuno, Yuko; Ninokata, Hisashi; Finnicum, David J.

2005-01-01

In this study, a probabilistic risk assessment (PRA) for the International Reactor Innovative and Secure (IRIS) has been generated to address two key areas as a part of the effort for the pre-application licensing of the IRIS design. First, the IRIS PRA is supporting the evaluation of IRIS design by providing design insights as well as a solid risk basis for the pre-licensing evaluation of the IRIS design. Second, the current PRA task is beginning the preparation of the more complete PRA analyses and documentation that will be required for Design Certification. The initial IRIS PRA is an at-power, Level-1 PRA for internal events that focuses on the evaluation of the IRIS design features to support the risk-informed design of IRIS by application of the PRA insights and the risk information to the design. To accomplish the evaluation, a reasonably complete Level-1 PRA model has been developed. The use of PRA in the early stages of the design has allowed a selection of design and performance features and an optimization of the design of several systems to reduce the potential for events that could lead to core damage via both enhanced prevention and mitigation of challenges. As a result, the total core damage frequency for internal events for the IRIS design has been calculated as 1.2x10 -8 per year

An evaluation of telehealth websites for design, literacy, information and content.

Science.gov (United States)

Whitten, Pamela; Holtz, Bree; Cornacchione, Jennifer; Wirth, Christina

2011-01-01

We examined 62 telehealth websites using four assessment criteria: design, literacy, information and telehealth content. The websites came from the member list of the American Telemedicine Association and the Office for the Advancement of Telehealth and partner sites, and were included if they were currently active and at least three clicks deep. Approximately 130 variables were examined for each website by two independent researchers. The websites reviewed contained most of the design variables (mean 74%, SD 6), but fewer of those relating to literacy (mean 26%, SD 6), website information (mean 35%, SD 16) and telehealth content (mean 37%, SD 18). Only 29% of websites encouraged users to ask about telehealth, and 19% contained information on overcoming telehealth barriers. Nonetheless, 84% promoted awareness of telehealth. All evaluation assessments were significantly correlated with each other except for literacy and information. The present study identified various matters that should be addressed when developing telehealth websites. Although much of this represents simple common sense in website design, our evaluation demonstrates that there is still much room for improvement.

Peripheral Social Awareness Information in Collaborative Work.

Science.gov (United States)

Spring, Michael B.; Vathanophas, Vichita

2003-01-01

Discusses being aware of other members of a team in a collaborative environment and reports on a study that examined group performance on a task that was computer mediated with and without awareness information. Examines how an awareness tool impacts the quality of a collaborative work effort and the communications between group members.…

Development of Information Technology of Object-relational Databases Design

Directory of Open Access Journals (Sweden)

Valentyn A. Filatov

2012-12-01

Full Text Available The article is concerned with the development of information technology of object-relational databases design and study of object features infological and logical database schemes entities and connections.

Angioplasty and stent placement - peripheral arteries - discharge

Science.gov (United States)

... medlineplus.gov/ency/patientinstructions/000234.htm Angioplasty and stent placement - peripheral arteries - discharge To use the sharing ... peripheral artery). You may have also had a stent placed. To perform the procedure: Your doctor inserted ...

Peripheral Ulcerative Keratitis

Science.gov (United States)

... oval in shape. Diagnosis A doctor's evaluation Sometimes culture The diagnosis of peripheral ulcerative keratitis is suspected when the doctor sees the affected cornea in a person who also has a severe and/or long- ...

PhyDesign: an online application for profiling phylogenetic informativeness

Directory of Open Access Journals (Sweden)

Townsend Jeffrey P

2011-05-01

Full Text Available Abstract Background The rapid increase in number of sequenced genomes for species across of the tree of life is revealing a diverse suite of orthologous genes that could potentially be employed to inform molecular phylogenetic studies that encompass broader taxonomic sampling. Optimal usage of this diversity of loci requires user-friendly tools to facilitate widespread cost-effective locus prioritization for phylogenetic sampling. The Townsend (2007 phylogenetic informativeness provides a unique empirical metric for guiding marker selection. However, no software or automated methodology to evaluate sequence alignments and estimate the phylogenetic informativeness metric has been available. Results Here, we present PhyDesign, a platform-independent online application that implements the Townsend (2007 phylogenetic informativeness analysis, providing a quantitative prediction of the utility of loci to solve specific phylogenetic questions. An easy-to-use interface facilitates uploading of alignments and ultrametric trees to calculate and depict profiles of informativeness over specified time ranges, and provides rankings of locus prioritization for epochs of interest. Conclusions By providing these profiles, PhyDesign facilitates locus prioritization increasing the efficiency of sequencing for phylogenetic purposes compared to traditional studies with more laborious and low capacity screening methods, as well as increasing the accuracy of phylogenetic studies. Together with a manual and sample files, the application is freely accessible at http://phydesign.townsend.yale.edu.

Evaluation of peripheral compression and auditory nerve fiber intensity coding using auditory steady-state responses

DEFF Research Database (Denmark)

Encina Llamas, Gerard; M. Harte, James; Epp, Bastian

2015-01-01

. Evaluation of these properties provides information about the health state of the system. It has been shown that a loss of outer hair cells leads to a reduction in peripheral compression. It has also recently been shown in animal studies that noise over-exposure, producing temporary threshold shifts, can....... The results indicate that the slope of the ASSR level growth function can be used to estimate peripheral compression simultaneously at four frequencies below 60 dB SPL, while the slope above 60 dB SPL may provide information about the integrity of intensity coding of low-SR fibers.......The compressive nonlinearity of the auditory system is assumed to be an epiphenomenon of a healthy cochlea and, particularly, of outer-hair cell function. Another ability of the healthy auditory system is to enable communication in acoustical environments with high-level background noises...

Hyperacute peripheral neuropathy is a predictor of oxaliplatin-induced persistent peripheral neuropathy.

Science.gov (United States)

Tanishima, Hiroyuki; Tominaga, Toshiji; Kimura, Masamichi; Maeda, Tsunehiro; Shirai, Yasutsugu; Horiuchi, Tetsuya

2017-05-01

Chronic peripheral neuropathy is a major adverse response to oxaliplatin-containing chemotherapy regimens, but there are no established risk factors pertaining to it. We investigated the efficacy of hyperacute peripheral neuropathy (HAPN) as a predictor of oxaliplatin-induced persistent peripheral neuropathy (PPN). Forty-seven cases of stage III colorectal cancer who received adjuvant chemotherapy with oxaliplatin after curative surgery between January 2010 and August 2014 were retrospectively reviewed. HAPN was defined as acute peripheral neuropathy (APN) occurring on day 1 (≤24 h after oxaliplatin infusion) of the first cycle. PPN was defined as neuropathy lasting >1 year after oxaliplatin discontinuation. The average total dose of oxaliplatin was 625.8 mg/m 2 , and the average relative dose intensity was 66.7%. Twenty-two of the 47 patients (46.8%) had PPN and 13 (27.7%) had HAPN. Male sex, treatment for neuropathy, HAPN, and APN were significantly more frequent in patients with PPN (p = 0.013, 0.02, <0.001, and 0.023, respectively). There was no significant difference in the total oxaliplatin dose between patients with and without PPN (p = 0.061). Multivariate analyses revealed total dose of oxaliplatin and HAPN as independent predictors of PPN [p = 0.015; odds ratio (OR) = 1.005, 95% confidence interval (CI), 1.001-1.009 and p = 0.001; OR = 75.307, 5.3-1070.123, respectively]. The total dose of oxaliplatin was relatively lower in patients with HAPN than that in those without HAPN in the PPN-positive group (not significant, p = 0.068). HAPN was found to be a predictor of oxaliplatin-induced PPN.

Information structure design for databases a practical guide to data modelling

CERN Document Server

Mortimer, Andrew J

2014-01-01

Computer Weekly Professional Series: Information Structure Design for Databases: A Practical Guide to Data modeling focuses on practical data modeling covering business and information systems. The publication first offers information on data and information, business analysis, and entity relationship model basics. Discussions cover degree of relationship symbols, relationship rules, membership markers, types of information systems, data driven systems, cost and value of information, importance of data modeling, and quality of information. The book then takes a look at entity relationship mode

Studies of peripheral sensory nerves in paclitaxel-induced painful peripheral neuropathy: Evidence for mitochondrial dysfunction

OpenAIRE

Flatters, Sarah J.L.; Bennett, Gary J.

2006-01-01

Paclitaxel chemotherapy frequently induces neuropathic pain during and often persisting after therapy. The mechanisms responsible for this pain are unknown. Using a rat model of paclitaxel-induced painful peripheral neuropathy, we have performed studies to search for peripheral nerve pathology. Paclitaxel-induced mechano-allodynia and mechano-hyperalgesia were evident after a short delay, peaked at day 27 and finally resolved on day 155. Paclitaxel- and vehicle-treated rats were perfused on d...

Effective Poster Design For Information Dissemination: The Ethics ...

African Journals Online (AJOL)

This article is written with an understanding that information communication posters are frequently prepared and used in all types of educational campaigns, but their planning, design and production rarely takes into consideration their effectiveness for the purpose they are prepared. The paper is thus aimed at discussing ...

Information Sharing in the Field of Design Research

Science.gov (United States)

Pilerot, Ola

2015-01-01

Introduction: This paper reports on an extensive research project which aimed at exploring information sharing activities in a scholarly context. The paper presents and synthesises findings from a literature review and three qualitative case studies. The empirical setting is a geographically distributed Nordic network of design scholars. Method:…

Peripheral Edema, Central Venous Pressure, and Risk of AKI in Critical Illness

Science.gov (United States)

Chen, Kenneth P.; Cavender, Susan; Lee, Joon; Feng, Mengling; Mark, Roger G.; Celi, Leo Anthony; Mukamal, Kenneth J.

2016-01-01

Background and objectives Although venous congestion has been linked to renal dysfunction in heart failure, its significance in a broader context has not been investigated. Design, setting, participants, & measurements Using an inception cohort of 12,778 critically ill adult patients admitted to an urban tertiary medical center between 2001 and 2008, we examined whether the presence of peripheral edema on admission physical examination was associated with an increased risk of AKI within the first 7 days of critical illness. In addition, in those with admission central venous pressure (CVP) measurements, we examined the association of CVPs with subsequent AKI. AKI was defined using the Kidney Disease Improving Global Outcomes criteria. Results Of the 18% (n=2338) of patients with peripheral edema on admission, 27% (n=631) developed AKI, compared with 16% (n=1713) of those without peripheral edema. In a model that included adjustment for comorbidities, severity of illness, and the presence of pulmonary edema, peripheral edema was associated with a 30% higher risk of AKI (95% confidence interval [95% CI], 1.15 to 1.46; Pedema was not significantly related to risk. Peripheral edema was also associated with a 13% higher adjusted risk of a higher AKI stage (95% CI, 1.07 to 1.20; Pedema were associated with 34% (95% CI, 1.10 to 1.65), 17% (95% CI, 0.96 to 1.14), 47% (95% CI, 1.18 to 1.83), and 57% (95% CI, 1.07 to 2.31) higher adjusted risk of AKI, respectively, compared with edema-free patients. In the 4761 patients with admission CVP measurements, each 1 cm H2O higher CVP was associated with a 2% higher adjusted risk of AKI (95% CI, 1.00 to 1.03; P=0.02). Conclusions Venous congestion, as manifested as either peripheral edema or increased CVP, is directly associated with AKI in critically ill patients. Whether treatment of venous congestion with diuretics can modify this risk will require further study. PMID:26787777

Peripheral denervation participates in heterotopic ossification in a spinal cord injury model.

Directory of Open Access Journals (Sweden)

Charlotte Debaud

Full Text Available We previously reported the development of a new acquired neurogenic HO (NHO mouse model, combining spinal cord transection (SCI and chemical muscle injury. Pathological mechanisms responsible for ectopic osteogenesis after central neurological damage are still to be elucidated. In this study, we first hypothesized that peripheral nervous system (PNS might convey pathological signals from injured spinal cord to muscles in NHO mouse model. Secondly, we sought to determine whether SCI could lead to intramuscular modifications of BMP2 signaling pathways. Twenty one C57Bl6 mice were included in this protocol. Bilateral cardiotoxin (CTX injection in hamstring muscles was associated with a two-stage surgical procedure, combining thoracic SCI with unilateral peripheral denervation. Volumes of HO (Bone Volume, BV were measured 28 days after surgery using micro-computed tomography imaging techniques and histological analyses were made to confirm intramuscular osteogenesis. Volume comparisons were conducted between right and left hind limb of each animal, using a Wilcoxon signed rank test. Quantitative polymerase chain reaction (qPCR was performed to explore intra muscular expression of BMP2, Alk3 and Id1. Nineteen mice survive the complete SCI and peripheral denervation procedure. When CTX injections were done right after surgery (n = 7, bilateral HO were detected in all animals after 28 days. Micro-CT measurements showed significantly increased BV in denervated paws (1.47 mm3 +/- 0.5 compared to contralateral sides (0.56 mm3 +/-0.4, p = 0.03. When peripheral denervation and CTX injections were performed after sham SCI surgery (n = 6, bilateral HO were present in three mice at day 28. Quantitative PCR analyses showed no changes in intra muscular BMP2 expression after SCI as compared to control mice (shamSCI. Peripheral denervation can be reliably added to spinal cord transection in NHO mouse model. This new experimental design confirms that neuro

Designing Health Websites Based on Users' Web-Based Information-Seeking Behaviors: A Mixed-Method Observational Study.

Science.gov (United States)

Pang, Patrick Cheong-Iao; Chang, Shanton; Verspoor, Karin; Pearce, Jon

2016-06-06

Laypeople increasingly use the Internet as a source of health information, but finding and discovering the right information remains problematic. These issues are partially due to the mismatch between the design of consumer health websites and the needs of health information seekers, particularly the lack of support for "exploring" health information. The aim of this research was to create a design for consumer health websites by supporting different health information-seeking behaviors. We created a website called Better Health Explorer with the new design. Through the evaluation of this new design, we derive design implications for future implementations. Better Health Explorer was designed using a user-centered approach. The design was implemented and assessed through a laboratory-based observational study. Participants tried to use Better Health Explorer and another live health website. Both websites contained the same content. A mixed-method approach was adopted to analyze multiple types of data collected in the experiment, including screen recordings, activity logs, Web browsing histories, and audiotaped interviews. Overall, 31 participants took part in the observational study. Our new design showed a positive result for improving the experience of health information seeking, by providing a wide range of information and an engaging environment. The results showed better knowledge acquisition, a higher number of page reads, and more query reformulations in both focused and exploratory search tasks. In addition, participants spent more time to discover health information with our design in exploratory search tasks, indicating higher engagement with the website. Finally, we identify 4 design considerations for designing consumer health websites and health information-seeking apps: (1) providing a dynamic information scope; (2) supporting serendipity; (3) considering trust implications; and (4) enhancing interactivity. Better Health Explorer provides strong

[Primary peripheral T-cell lymphoma of the penis: a case report and review of the literature].

Science.gov (United States)

Shi, Yan-Lin; Yin, Hong-Lin; Zhou, Xiao-Jun; Zhou, Hang-Bo; Lu, Zhen-Feng

2008-11-01

To report a case of primary peripheral T-cell lymphoma of the penis. We analyzed the clinicopathological characteristics of the case of primary peripheral T-cell lymphoma using histological, cytochemical and immunohistochemical methods and by review of the literature. The patient was a 65 years old man and presented with a diffuse enlargement of the penis as the initial sign, followed by erosive ulcer in the caput penis and inguinal lymphadenectasis. The tumor was pathohistologically manifested as an epidermal ulcer, with tumorous necrosis around the capillary, infiltrative growth and atypical changes of the neoplastic cells and proliferation of capillaries. Immunohistochemically, the tumor cells were positive for CD43 and CD3, but negative for CD20, CD79a, CD34, CD30, CD56 and CD34. Clinically it responded to the chemotherapy designed for peripheral T-cell lymphoma. Primary peripheral T-cell lymphoma of the penis is an extremely rare malignant tumor, the diagnosis of which relies on histopathological examination, immunohistochemical staining and differentiation between squamous cell carcinoma and other types of lymphoma.

Population coding of forelimb joint kinematics by peripheral afferents in monkeys.

Directory of Open Access Journals (Sweden)

Tatsuya Umeda

Full Text Available Various peripheral receptors provide information concerning position and movement to the central nervous system to achieve complex and dexterous movements of forelimbs in primates. The response properties of single afferent receptors to movements at a single joint have been examined in detail, but the population coding of peripheral afferents remains poorly defined. In this study, we obtained multichannel recordings from dorsal root ganglion (DRG neurons in cervical segments of monkeys. We applied the sparse linear regression (SLiR algorithm to the recordings, which selects useful input signals to reconstruct movement kinematics. Multichannel recordings of peripheral afferents were performed by inserting multi-electrode arrays into the DRGs of lower cervical segments in two anesthetized monkeys. A total of 112 and 92 units were responsive to the passive joint movements or the skin stimulation with a painting brush in Monkey 1 and Monkey 2, respectively. Using the SLiR algorithm, we reconstructed the temporal changes of joint angle, angular velocity, and acceleration at the elbow, wrist, and finger joints from temporal firing patterns of the DRG neurons. By automatically selecting a subset of recorded units, the SLiR achieved superior generalization performance compared with a regularized linear regression algorithm. The SLiR selected not only putative muscle units that were responsive to only the passive movements, but also a number of putative cutaneous units responsive to the skin stimulation. These results suggested that an ensemble of peripheral primary afferents that contains both putative muscle and cutaneous units encode forelimb joint kinematics of non-human primates.

Information Design: A New Approach to Teaching Technical Writing Service Courses

Science.gov (United States)

McKee, Candie DeLane

2012-01-01

This study used a needs assessment, process analysis, process design, and textbook design to develop a new process and new textbook, based on Cargile-Cook's layered literacies, Quesenbery's five qualities of usability, and Carliner's information design theories, for use in technical writing service learning courses. The needs assessment was based…

Transcriptomic profiles of peripheral white blood cells in type II diabetes and racial differences in expression profiles

Directory of Open Access Journals (Sweden)

Mao Jinghe

2011-12-01

Full Text Available Abstract Background Along with obesity, physical inactivity, and family history of metabolic disorders, African American ethnicity is a risk factor for type 2 diabetes (T2D in the United States. However, little is known about the differences in gene expression and transcriptomic profiles of blood in T2D between African Americans (AA and Caucasians (CAU, and microarray analysis of peripheral white blood cells (WBCs from these two ethnic groups will facilitate our understanding of the underlying molecular mechanism in T2D and identify genetic biomarkers responsible for the disparities. Results A whole human genome oligomicroarray of peripheral WBCs was performed on 144 samples obtained from 84 patients with T2D (44 AA and 40 CAU and 60 healthy controls (28 AA and 32 CAU. The results showed that 30 genes had significant difference in expression between patients and controls (a fold change of 1.4 with a P value Conclusions These newly identified genetic markers in WBCs provide valuable information about the pathophysiology of T2D and can be used for diagnosis and pharmaceutical drug design. Our results also found that AA and CAU patients with T2D express genes and pathways differently.

Secure Retrieval of FFTF Testing, Design, and Operating Information

International Nuclear Information System (INIS)

Butner, R. Scott; Wootan, David W.; Omberg, Ronald P.; Makenas, Bruce J.; Nielsen, Deborah

2009-01-01

One of the goals of the Advanced Fuel Cycle Initiative (AFCI) is to preserve the knowledge that has been gained in the United States on Liquid Metal Reactors (LMR). In addition, preserving LMR information and knowledge is part of a larger international collaborative activity conducted under the auspices of the International Atomic Energy Agency (IAEA). A similar program is being conducted for EBR-II at the Idaho Nuclear Laboratory (INL) and international programs are also in progress. Knowledge preservation at the FFTF is focused on the areas of design, construction, startup, and operation of the reactor. As the primary function of the FFTF was testing, the focus is also on preserving information obtained from irradiation testing of fuels and materials. This information will be invaluable when, at a later date, international decisions are made to pursue new LMRs. In the interim, this information may be of potential use for international exchanges with other LMR programs around the world. At least as important in the United States, which is emphasizing large-scale computer simulation and modeling, this information provides the basis for creating benchmarks for validating and testing these large scale computer programs. Although the preservation activity with respect to FFTF information as discussed below is still underway, the team of authors above is currently retrieving and providing experimental and design information to the LMR modeling and simulation efforts for use in validating their computer models. On the Hanford Site, the FFTF reactor plant is one of the facilities intended for decontamination and decommissioning consistent with the cleanup mission on this site. The reactor facility has been deactivated and is being maintained in a cold and dark minimal surveillance and maintenance mode until final decommissioning is pursued. In order to ensure protection of information at risk, the program to date has focused on sequestering and secure retrieval

Review on Application of Building Information Modelling in Interior Design Industry

Directory of Open Access Journals (Sweden)

Abd Hamid Abu Bakar

2016-01-01

Full Text Available Building Information Modeling (BIM is a flourishing device and approach for Architecture, Engineering and Construction (AEC which assist; the planning, design, constructions and operation with particular to commence the designing in several components of the building, a comprehensive understanding of the activities and needed in all aspects. An aspect of activities and needs is the first step to be analysed in the design and it is the responsibility of professionals’ interior designers. To solve the problems, is required to attach with the certain factors such as space planning, specifications fixture, equipment and material, furniture and finishing, lighting fixing and service management. BIM application can provide interior designers such as simulation, analysis, design process and solution with team members. Furthermore, some of the interior designer also using BIM as to organize, documenting data and optimise detail information in solving the problem in the develop process. BIM technology and practices not only to improve the construction and design process development that only the project faster, cost effectively, and prolong but it also helps to increase the capacity of BIM professional by improvise the careers and fields. In the Malaysian context, BIM is still fresh in interior desogn industry.

Understanding teachers’ routines to inform classroom technology design

OpenAIRE

An, P.; Bakker, S.; Eggen, J.H.

2017-01-01

Secondary school teachers have quite busy and complex routines in their classrooms. However, present classroom technologies usually require focused attention from teachers while being interacted with, which restricts their use in teachers’ daily routines. Peripheral interaction is a human-computer interaction style that aims to enable interaction to take place both in the center and periphery of users’ attention and naturally shift between the two. We believe that classroom technologies emplo...

Respiratory Syncytial Virus (RSV RNA loads in peripheral blood correlates with disease severity in mice

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Torres Juan

2010-09-01

Full Text Available Abstract Background Respiratory Syncytial Virus (RSV infection is usually restricted to the respiratory epithelium. Few studies have documented the presence of RSV in the systemic circulation, however there is no consistent information whether virus detection in the blood correlates with disease severity. Methods Balb/c mice were inoculated with live RSV, heat-inactivated RSV or medium. A subset of RSV-infected mice was treated with anti-RSV antibody 72 h post-inoculation. RSV RNA loads were measured by PCR in peripheral blood from day 1-21 post-inoculation and were correlated with upper and lower respiratory tract viral loads, the systemic cytokine response, lung inflammation and pulmonary function. Immunohistochemical staining was used to define the localization of RSV antigens in the respiratory tract and peripheral blood. Results RSV RNA loads were detected in peripheral blood from day 1 to 14 post-inoculation, peaked on day 5 and significantly correlated with nasal and lung RSV loads, airway obstruction, and blood CCL2 and CXCL1 expression. Treatment with anti-RSV antibody reduced blood RSV RNA loads and improved airway obstruction. Immunostaining identified RSV antigens in alveolar macrophages and peripheral blood monocytes. Conclusions RSV RNA was detected in peripheral blood upon infection with live RSV, followed a time-course parallel to viral loads assessed in the respiratory tract and was significantly correlated with RSV-induced airway disease.

Participatory Design of Large-Scale Information Systems

DEFF Research Database (Denmark)

Simonsen, Jesper; Hertzum, Morten

2008-01-01

into a PD process model that (1) emphasizes PD experiments as transcending traditional prototyping by evaluating fully integrated systems exposed to real work practices; (2) incorporates improvisational change management including anticipated, emergent, and opportunity-based change; and (3) extends initial...... design and development into a sustained and ongoing stepwise implementation that constitutes an overall technology-driven organizational change. The process model is presented through a largescale PD experiment in the Danish healthcare sector. We reflect on our experiences from this experiment......In this article we discuss how to engage in large-scale information systems development by applying a participatory design (PD) approach that acknowledges the unique situated work practices conducted by the domain experts of modern organizations. We reconstruct the iterative prototyping approach...

Peripheral epithelial odontogenic tumor

International Nuclear Information System (INIS)

Carzoglio, J.; Tancredi, N.; Capurro, S.; Ravecca, T.; Scarrone, P.

2006-01-01

A new case of peripheral epithelial odontogenic tumor (Pindborg tumor) is reported. It is localized in the superior right gingival region, a less frequent site, and has the histopathological features previously reported. Immunochemical studies were performed, revealing a differential positive stain to cytokeratins in tumor cells deeply seated in the tumor mass, probably related to tumoral cell heterogeneity.Interestingly, in this particular case S-100 protein positive reactivity was also detected in arborescent cells intermingled with tumoral cells, resembling Langerhans cells. Even though referred in the literature in central Pindborg tumors, no references were found about their presence in peripheral tumors, like the one that is presented here

Prevalence of Neuropathy and Peripheral Arterial Disease and the Impact of Treatment in People With Screen-Detected Type 2 Diabetes: The ADDITION-Denmark study

DEFF Research Database (Denmark)

Charles, Morten; Ejskjær, Niels; Witte, Daniel R

2011-01-01

in primary care on the prevalence of diabetic peripheral neuropathy (DPN) and peripheral arterial disease (PAD) 6 years later in a pragmatic, cluster-randomized parallel group trial. RESEARCH DESIGN AND METHODS-A stepwise screening program in 1.90 general practices in Denmark was used to identify 1...

Haemopoietic progenitor cells in human peripheral blood

International Nuclear Information System (INIS)

Zwaan, F.E.

1980-01-01

The purpose of the investigation reported is to purify haemopoietic progenitor cells from human peripheral blood using density gradient centrifugation in order to isolate a progenitor cell fraction without immunocompetent cells. The purification technique of peripheral blood flow colony forming unit culture (CFU-c) by means of density gradient centrifugation and a combined depletion of various rosettes is described. The results of several 'in vitro' characteristics of purified CFU-c suspensions and of the plasma clot diffusion chamber culture technique are presented. Irradiation studies revealed that for both human bone marrow and peripheral blood the CFU-c were less radioresistant than clusters. Elimination of monocytes (and granulocytes) from the test suspensions induced an alteration in radiosensitivity pararmeters. The results obtained with the different techniques are described by analysing peripheral progenitor cell activity in myeloproliferative disorders. (Auth.)

Label-free photoacoustic microscopy of peripheral nerves

Science.gov (United States)

Matthews, Thomas Paul; Zhang, Chi; Yao, Da-Kang; Maslov, Konstantin; Wang, Lihong V.

2014-01-01

Peripheral neuropathy is a common neurological problem that affects millions of people worldwide. Diagnosis and treatment of this condition are often hindered by the difficulties in making objective, noninvasive measurements of nerve fibers. Photoacoustic microscopy (PAM) has the ability to obtain high resolution, specific images of peripheral nerves without exogenous contrast. We demonstrated the first proof-of-concept imaging of peripheral nerves using PAM. As validated by both standard histology and photoacoustic spectroscopy, the origin of photoacoustic signals is myelin, the primary source of lipids in the nerves. An extracted sciatic nerve sandwiched between two layers of chicken tissue was imaged by PAM to mimic the in vivo case. Ordered fibrous structures inside the nerve, caused by the bundles of myelin-coated axons, could be observed clearly. With further technical improvements, PAM can potentially be applied to monitor and diagnose peripheral neuropathies.

Towards the Design of a WAP-based Environmental Information Service

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Joerg Westbomke

2004-12-01

Full Text Available Cellular phones have almost replaced conventional telephones for public use in Western European countries. Modern WAP enhanced phones or smart phones offer mobile access to the internet, anytime and anyplace. This technique therefore appears to be very attractive for transferring up-to-date information about the environmental situation to the public, i.e. air and water quality measurements or weather conditions as well as forecasted values of these processes. The Wireless Application Protocol (WAP is the key technology in this respect. According to the upcoming importance of mobile internet access the WAP technology has great potentials to play an important role in the design of modern information services which are user centered. Because of upcoming environmental laws in Europe the citizen will gain the right to access the environmental information collected and stored by the public authorities. But due to size and resolution of the displays used in the actual versions of the cellular phones it is not sufficient to transfer the concepts and architectures known from internet information systems to WAP-based systems. It is rather necessary to develop special concepts for the design of WAPbased services, with a special focus on the appropriate structuring and presentation of environmental data. This paper gives an overview of the main problems WAP system designer had actually to deal with and shows concepts how to solve them. At the end of the paper we present two mobile environmental information services, which were realized on the basis of the presented concepts.

Peripheral Neuropathy and Nerve Compression Syndromes in Burns.

Science.gov (United States)

Strong, Amy L; Agarwal, Shailesh; Cederna, Paul S; Levi, Benjamin

2017-10-01

Peripheral neuropathy and nerve compression syndromes lead to substantial morbidity following burn injury. Patients present with pain, paresthesias, or weakness along a specific nerve distribution or experience generalized peripheral neuropathy. The symptoms manifest at various times from within one week of hospitalization to many months after wound closure. Peripheral neuropathy may be caused by vascular occlusion of vasa nervorum, inflammation, neurotoxin production leading to apoptosis, and direct destruction of nerves from the burn injury. This article discusses the natural history, diagnosis, current treatments, and future directions for potential interventions for peripheral neuropathy and nerve compression syndromes related to burn injury. Copyright © 2017 Elsevier Inc. All rights reserved.

Peripheral orbit model

CERN Document Server

Hara, Yasuo

1975-01-01

Peripheral orbit model, in which an incoming hadron is assumed to revolve in a peripheral orbit around a target hadron, is discussed. The non-diffractive parts of two-body reaction amplitudes of hadrons are expressed in terms of the radius, width an absorptivity of the orbit. The radius of the orbit is about 1 fm and the width of the orbit is determined by the range of the interaction between the hadrons. The model reproduces all available experimental data on differential cross-sections and polarizations of $K^{-}p\\to K^{-}p$ and $\\bar K^{\\circ}n$ reactions for all angles successfully. This contribution is not included in the proceedings since it will appear in Progress of Theoretical Physics Vol. 51 (1974) No 2. Any person interested in the subject may apply for reprints to the author.

User perception and interpretation of tornado probabilistic hazard information: Comparison of four graphical designs.

Science.gov (United States)

Miran, Seyed M; Ling, Chen; James, Joseph J; Gerard, Alan; Rothfusz, Lans

2017-11-01

Effective design for presenting severe weather information is important to reduce devastating consequences of severe weather. The Probabilistic Hazard Information (PHI) system for severe weather is being developed by NOAA National Severe Storms Laboratory (NSSL) to communicate probabilistic hazardous weather information. This study investigates the effects of four PHI graphical designs for tornado threat, namely, "four-color"," red-scale", "grayscale" and "contour", on users' perception, interpretation, and reaction to threat information. PHI is presented on either a map background or a radar background. Analysis showed that the accuracy was significantly higher and response time faster when PHI was displayed on map background as compared to radar background due to better contrast. When displayed on a radar background, "grayscale" design resulted in a higher accuracy of responses. Possibly due to familiarity, participants reported four-color design as their favorite design, which also resulted in the fastest recognition of probability levels on both backgrounds. Our study shows the importance of using intuitive color-coding and sufficient contrast in conveying probabilistic threat information via graphical design. We also found that users follows a rational perceiving-judging-feeling-and acting approach in processing probabilistic hazard information for tornado. Copyright © 2017 Elsevier Ltd. All rights reserved.

Case report of a patient with peripheral facial nerve palsy

OpenAIRE

Rysová, Jana

2013-01-01

Title of bachelor's thesis: Case report of a patient with peripheral facial nerve palsy Summary: Teoretical part of bachelor's thesis contains theoretical foundation of peripheral facial nerve palsy. Practical part of bachelor's thesis contains physiotherapeutic case report of patient with peripheral facial nerve palsy. Key words: peripheral facial nerve palsy, casuistry, rehabilitation

Technical and economic assessment of design efficiency of information and measuring systems

Science.gov (United States)

Yurov, V. M.; Eremin, E. N.; Baisagov, Ya Zh; Arkhipov, V. V.

2018-01-01

A thermodynamic approach to the analysis of information-measuring systems (IMS) is developed in the work. Expressions for efficiency of IMS are obtained. The connection between the amount of processor memory and the amount of incoming information and the accuracy of the IMS is obtained. It is shown that the probability of information loss in IMS decreases with the increase in the amount of information from the object. Using the analogy method, economic aspects of IMS design are considered. The innate ability of IMS and Moore’s law are considered. The proposed approach and the resulting formulas will be useful in the design of new IMS.

Image-guided core-needle biopsy of peripheral lymph nodes allows the diagnosis of lymphomas

International Nuclear Information System (INIS)

Kerviler, Eric de; Bazelaire, Cedric de; Mathieu, Olivier; Frija, Jacques; Mounier, Nicolas; Gisselbrecht, Christian; Brethon, Benoit; Briere, Josette; Marolleau, Jean-Pierre; Brice, Pauline

2007-01-01

It is commonly admitted that the diagnosis of lymphomas can be assessed by the image-guided needle biopsy (IGNB) of deep lymph nodes. However, when peripheral lymph nodes are present, surgical dissection remains the standard strategy. The aim of this study was to evaluate the diagnostic yield of IGNB of peripheral lymph nodes in patients with suspected lymphomas. The records of 180 multisampling IGNBs of peripheral lymph nodes in 180 patients were reviewed. One hundred and twenty-three IGNBs were observed at first diagnosis and 57 at progression using large-cutting core-biopsy needles ranging between 18 G and 14 G in size. Immunohistochemistry studies were performed in all cases and at least one biopsy was systematically frozen. A diagnosis of lymphoma with sufficient information such that a therapeutic decision could be made was obtained in 146 of the 152 patients with lymphoproliferative disorders (96%). IGNB was equally effective in making the correct diagnosis of lymphoma at the time of original diagnosis than at relapse. The results did not depend on the biopsy site, lymph nodes size, or needle type. We recommend that IGNB may be performed as an initial procedure for the diagnosis of lymphomas either in the presence of peripheral or deep lymph nodes, as it avoids surgery. (orig.)

Peripheral involvement of the joint in seronegative spondylarthritis; Periphere Gelenkbeteiligung bei seronegativen Spondarthritiden

Energy Technology Data Exchange (ETDEWEB)

Lingg, G.; Soltesz, I. [Rheumazentrum Bad Kreuznach (Germany). Zentrales Roentgeninstitut

1997-10-01

The subjects of this contributions have been restricted to the peripheral manifestations of seronegative spondylarthrosis, for reasons of conciseness and clearness. The most frequent occurrences discussed are psoriasis arthritis and, a little bit less frequent, peripheral involvement of the joint in ancylosing spondylitis and Reiter syndrome, as well as enteropathic spondylarthrosis. (orig./AJ) [Deutsch] Als Thema dieser Veroeffentlichung wurden aus Gruenden der Kuerze und der Uebersichtlichkeit aber nur die peripheren Manifestationen der seronegativen Spondarthropathien gewaehlt. Hier wiederum haben wir es am haeufigsten mit der Psoriasisarthritis und etwas seltener mit der peripheren Gelenkbeteiligung bei der Bechterew`schen Erkrankung und der Reiter`schen Erkrankung sowie der enteropathischen Spondarthritiden zu tun. (orig./AJ)

Imaging of the peripheral vascular system

International Nuclear Information System (INIS)

Gould, S.A.; Pond, G.D.; Pinsky, S.; Moss, G.S.; Srikantaswamy, S.; Ryo, U.Y.

1984-01-01

This book is limited neither to the peripheral vascular system nor to diagnostic imaging techniques. Its 18 chapters cover nonimaging blood-flow techniques (Doppler ultrasound, plethysmography) as well as noninvasive and invasive imaging techniques (ultrasound, computed tomography, radionuclide digital-subtraction angiography, and contrast angiography). These are applied not only to the peripheral vascular system but also to the aorta and vena cava

Evaluating procedural modelling for 3D models of informal settlements in urban design activities

Directory of Open Access Journals (Sweden)

Victoria Rautenbach

2015-11-01

Full Text Available Three-dimensional (3D modelling and visualisation is one of the fastest growing application fields in geographic information science. 3D city models are being researched extensively for a variety of purposes and in various domains, including urban design, disaster management, education and computer gaming. These models typically depict urban business districts (downtown or suburban residential areas. Despite informal settlements being a prevailing feature of many cities in developing countries, 3D models of informal settlements are virtually non-existent. 3D models of informal settlements could be useful in various ways, e.g. to gather information about the current environment in the informal settlements, to design upgrades, to communicate these and to educate inhabitants about environmental challenges. In this article, we described the development of a 3D model of the Slovo Park informal settlement in the City of Johannesburg Metropolitan Municipality, South Africa. Instead of using time-consuming traditional manual methods, we followed the procedural modelling technique. Visualisation characteristics of 3D models of informal settlements were described and the importance of each characteristic in urban design activities for informal settlement upgrades was assessed. Next, the visualisation characteristics of the Slovo Park model were evaluated. The results of the evaluation showed that the 3D model produced by the procedural modelling technique is suitable for urban design activities in informal settlements. The visualisation characteristics and their assessment are also useful as guidelines for developing 3D models of informal settlements. In future, we plan to empirically test the use of such 3D models in urban design projects in informal settlements.

Raman spectroscopic detection of peripheral nerves towards nerve-sparing surgery

Science.gov (United States)

Minamikawa, Takeo; Harada, Yoshinori; Takamatsu, Tetsuro

2017-02-01

The peripheral nervous system plays an important role in motility, sensory, and autonomic functions of the human body. Preservation of peripheral nerves in surgery, namely nerve-sparing surgery, is now promising technique to avoid functional deficits of the limbs and organs following surgery as an aspect of the improvement of quality of life of patients. Detection of peripheral nerves including myelinated and unmyelinated nerves is required for the nerve-sparing surgery; however, conventional nerve identification scheme is sometimes difficult to identify peripheral nerves due to similarity of shape and color to non-nerve tissues or its limited application to only motor peripheral nerves. To overcome these issues, we proposed a label-free detection technique of peripheral nerves by means of Raman spectroscopy. We found several fingerprints of peripheral myelinated and unmyelinated nerves by employing a modified principal component analysis of typical spectra including myelinated nerve, unmyelinated nerve, and adjacent tissues. We finally realized the sensitivity of 94.2% and the selectivity of 92.0% for peripheral nerves including myelinated and unmyelinated nerves against adjacent tissues. Although further development of an intraoperative Raman spectroscopy system is required for clinical use, our proposed approach will serve as a unique and powerful tool for peripheral nerve detection for nerve-sparing surgery in the future.

Collaborative ethnography for information systems research Studying knowledge work practices and designing supportive information systems

Directory of Open Access Journals (Sweden)

Ronald Maier

2012-04-01

Full Text Available Understanding knowledge work and supporting it with information systems (ISs are challenging tasks. Knowledge work has changed substantially recently and studies on how knowledge work is currently performed are scarce. Ethnography is the most suitable qualitative research method for studying knowledge work, yet too time-consuming, costly and unfocused for the fast changing IS domain. Moreover, results from qualitative studies need to be transformed into artefacts useful for IS requirements engineering and design. This paper proposes a procedure for collaborative ethnography to study knowledge work practices and inform IS requirements gathering and design illustrated with the case of a collaborative ethnographic study of seven organisations in four European countries performed in a large-scale international IS research and development project. The paper also critically discusses the procedure’s applicability and limitations.

Mechanisms of Communicating Health Information Through Facebook: Implications for Consumer Health Information Technology Design.

Science.gov (United States)

Menefee, Hannah K; Thompson, Morgan J; Guterbock, Thomas M; Williams, Ishan C; Valdez, Rupa S

2016-08-11

Consumer health information technology (IT) solutions are designed to support patient health management and have the ability to facilitate patients' health information communication with their social networks. However, there is a need for consumer health IT solutions to align with patients' health management preferences for increased adoption of the technology. It may be possible to gain an understanding of patients' needs for consumer health IT supporting their health information communication with social networks by explicating how they have adopted and adapted social networking sites, such as Facebook, for this purpose. Our aim was to characterize patients' use of all communication mechanisms within Facebook for health information communication to provide insight into how consumer health IT solutions may be better designed to meet patients' communication needs and preferences. This study analyzed data about Facebook communication mechanisms use from a larger, three-phase, sequential, mixed-methods study. We report here on the results of the study's first phase: qualitative interviews (N=25). Participants were over 18, used Facebook, were residents or citizens of the United States, spoke English, and had a diagnosis consistent with type 2 diabetes. Participants were recruited through Facebook groups and pages. Participant interviews were conducted via Skype or telephone between July and September 2014. Data analysis was grounded in qualitative content analysis and the initial coding framework was informed by the findings of a previous study. Participants' rationales for the use or disuse of a particular Facebook mechanism to communicate health information reflected six broad themes: (1) characteristics and circumstances of the person, (2) characteristics and circumstances of the relationship, (3) structure and composition of the social network, (4) content of the information, (5) communication purpose, and (6) attributes of the technology. The results of this

The Design of Case Products’ Shape Form Information Database Based on NURBS Surface

Science.gov (United States)

Liu, Xing; Liu, Guo-zhong; Xu, Nuo-qi; Zhang, Wei-she

2017-07-01

In order to improve the computer design of product shape design,applying the Non-uniform Rational B-splines(NURBS) of curves and surfaces surface to the representation of the product shape helps designers to design the product effectively.On the basis of the typical product image contour extraction and using Pro/Engineer(Pro/E) to extract the geometric feature of scanning mold,in order to structure the information data base system of value point,control point and node vector parameter information,this paper put forward a unified expression method of using NURBS curves and surfaces to describe products’ geometric shape and using matrix laboratory(MATLAB) to simulate when products have the same or similar function.A case study of electric vehicle’s front cover illustrates the access process of geometric shape information of case product in this paper.This method can not only greatly reduce the capacity of information debate,but also improve the effectiveness of computer aided geometric innovation modeling.

[Atherectomy for peripheral arterial disease].

Science.gov (United States)

Londero, Louise Skovgaard; Høgh, Annette Langager; Lindholt, Jes Sanddal

2015-04-13

Symptomatic peripheral arterial disease is managed according to national and international guidelines and the number of vascular reconstructions performed each year has increased over the past decade mainly due to an increasing frequency of endovascular procedures. Atherectomy as an alternative to the established treatment of symptomatic peripheral arterial disease has recently been analysed in a Cochrane review. In Denmark, atherectomy is not performed and so far the evidence is poor as the method is not an alternative to the established treatment in this country.

Engineering Design Thinking and Information Gathering. Final Report. Research in Engineering and Technology Education

Science.gov (United States)

Mentzer, Nathan

2011-01-01

The objective of this research was to explore the relationship between information access and design solution quality of high school students presented with an engineering design problem. This objective is encompassed in the research question driving this inquiry: How does information access impact the design process? This question has emerged in…

Chronic obstructive pulmonary disease and peripheral neuropathy

Directory of Open Access Journals (Sweden)

Gupta Prem

2006-01-01

Full Text Available Chronic obstructive pulmonary disease (COPD is the fourth leading cause of death world-wide and a further increase in the prevalence as well as mortality of the disease is predicted for coming decades. There is now an increased appreciation for the need to build awareness regarding COPD and to help the thousands of people who suffer from this disease and die prematurely from COPD or its associated complication(s. Peripheral neuropathy in COPD has received scanty attention despite the fact that very often clinicians come across COPD patients having clinical features suggestive of peripheral neuropathy. Electrophysiological tests like nerve conduction studies are required to distinguish between axonal and demyelinating type of disorder that cannot be analyzed by clinical examination alone. However, various studies addressing peripheral neuropathy in COPD carried out so far have included patients with COPD having markedly varying baseline characteristics like severe hypoxemia, elderly patients, those with long duration of illness, etc. that are not uniform across the studies and make it difficult to interpret the results to a consistent conclusion. Almost one-third of COPD patients have clinical evidence of peripheral neuropathy and two-thirds have electrophysiological abnormalities. Some patients with no clinical indication of peripheral neuropathy do have electrophysiological deficit suggestive of peripheral neuropathy. The more frequent presentation consists of a polyneuropathy that is subclinical or with predominantly sensory signs, and the neurophysiological and pathological features of predominantly axonal neuropathy. The presumed etiopathogenic factors are multiple: chronic hypoxia, tobacco smoke, alcoholism, malnutrition and adverse effects of certain drugs.

User Preferences for Web-Based Module Design Layout and Design Impact on Information Recall Considering Age

Science.gov (United States)

Pomales-García, Cristina; Rivera-Nivar, Mericia

2015-01-01

Research in design of Web-based modules should incorporate aging as an important factor given the diversity of the current workforce. This work aims to understand how Web-Based Learning modules can be designed to accommodate young (25-35 years) as well as older (55-65 years) users by: (1) identifying how information sources (instructor video,…

Informational ergonomics and design: signage design for Monte Sião Camp.

Science.gov (United States)

Marques, Luiz Guilherme Oliveira; Cardoso, Vânia Maria Batalha

2012-01-01

This paper refers to the development of a signage system, driven by the vector of Signage Design and Informational Ergonomics associated with Regulatory Standards. The methodology of the Ergonomic Intervention of Moraes and Mont'Alvão (2003), in its early stages, and the Method of the Signage Pyramid of Calori (2007) were used to develop the research, data collection and analysis and to guide the design by a signaling system. The system contemplated by this job is called Mount Zion, a site of 19 hectares, which has signs of disturbance. As a result, we obtained a signaling system, with graphic features that refer to formal-site, capable of meeting the needs of orientation and displacement inherent to the site.

Mitchell's influence on European studies of peripheral nerve injuries during World War I.

Science.gov (United States)

Koehler, Peter J; Lanska, Douglas J

2004-12-01

Describe the influence of S. Weir Mitchell's (1829-1914) work, and in particular his ideas on causalgia, on European physicians who treated peripheral nerve injuries during World War I (WWI). During the American Civil War (1861-1865), Mitchell studied peripheral nerve injuries with colleagues George Read Morehouse and William Williams Keen. Three monographs resulted from this work. All were important landmarks in the evolution of knowledge of peripheral nerve injuries. A subsequent occasion to improve knowledge came in WWI. The most important European monographs or series on peripheral nerve injuries from WWI were studied with special interest in references to causalgia and Mitchell's works on peripheral nerve injuries. We included works by Tinel, Athanassio-Benisty, Purves-Stewart & Evans and Carter, Foerster and Oppenheim. Tinel and Athanassio-Benisty provided the most detailed information on peripheral nerve injuries and causalgia and often referred to Mitchell. Both mentioned a possible sympathetic origin. Athanassio-Benisty described tremor and other movement disorders in relation to causalgia. Purves-Stewart and Evans mentioned Mitchell and causalgia in the second edition of their book. They advocated the term "thermalgia." Carter, who had access to data of many cases, concentrated his work on causalgia, referring to Mitchell. Foerster provided data of a great number of peripheral nerve injuries, but did not refer to Mitchell. However, he described the symptoms of causalgia cursorily, applying the term Reflexschmerz (reflexpain). Oppenheim was particularly interested in muscle innervation and referred to Mitchell with respect to hypertrichosis and glossy skin. Oppenheim did not use the term causalgia, although he described the syndrome in some of his patients. It wasn't until around 1920 that German physicians devoted significant attention to causalgia and began using the term. Knowledge of peripheral nerve injuries was greatly advanced during and after WWI

Peripheral Nervous System Manifestations in Systemic Autoimmune Diseases

OpenAIRE

COJOCARU, Inimioara Mihaela; COJOCARU, Manole; SILOSI, Isabela; VRABIE, Camelia Doina

2014-01-01

The peripheral nervous system refers to parts of the nervous system outside the brain and spinal cord. Systemic autoimmune diseases can affect both the central and peripheral nervous systems in a myriad of ways and through a heterogeneous number of mechanisms leading to many different clinical manifestations. As a result, neurological complications of these disorders can result in significant morbidity and mortality. The most common complication of peripheral nervous system (PNS) involvement ...

Passive Scalar Evolution in Peripheral Region

OpenAIRE

Lebedev, V. V.; Turitsyn, K. S.

2003-01-01

We consider evolution of a passive scalar (concentration of pollutants or temperature) in a chaotic (turbulent) flow. A universal asymptotic behavior of the passive scalar decay (homogenization) related to peripheral regions (near walls) is established. The passive scalar moments and its pair correlation function in the peripheral region are analyzed. A special case investigated in our paper is the passive scalar decay along a pipe.

Design and information requirements for travel and tourism needs on scenic byways.

Science.gov (United States)

1994-01-01

The purpose of this study was to develop a system design and information evaluation process that could be used to review proposed or designated scenic byways. The process was intended to ensure that the geometric and traffic design of these roads wer...

Selectivity and Longevity of Peripheral-Nerve and Machine Interfaces: A Review

Directory of Open Access Journals (Sweden)

Usman Ghafoor

2017-10-01

Full Text Available For those individuals with upper-extremity amputation, a daily normal living activity is no longer possible or it requires additional effort and time. With the aim of restoring their sensory and motor functions, theoretical and technological investigations have been carried out in the field of neuroprosthetic systems. For transmission of sensory feedback, several interfacing modalities including indirect (non-invasive, direct-to-peripheral-nerve (invasive, and cortical stimulation have been applied. Peripheral nerve interfaces demonstrate an edge over the cortical interfaces due to the sensitivity in attaining cortical brain signals. The peripheral nerve interfaces are highly dependent on interface designs and are required to be biocompatible with the nerves to achieve prolonged stability and longevity. Another criterion is the selection of nerves that allows minimal invasiveness and damages as well as high selectivity for a large number of nerve fascicles. In this paper, we review the nerve-machine interface modalities noted above with more focus on peripheral nerve interfaces, which are responsible for provision of sensory feedback. The invasive interfaces for recording and stimulation of electro-neurographic signals include intra-fascicular, regenerative-type interfaces that provide multiple contact channels to a group of axons inside the nerve and the extra-neural-cuff-type interfaces that enable interaction with many axons around the periphery of the nerve. Section Current Prosthetic Technology summarizes the advancements made to date in the field of neuroprosthetics toward the achievement of a bidirectional nerve-machine interface with more focus on sensory feedback. In the Discussion section, the authors propose a hybrid interface technique for achieving better selectivity and long-term stability using the available nerve interfacing techniques.

Selectivity and Longevity of Peripheral-Nerve and Machine Interfaces: A Review

Science.gov (United States)

Ghafoor, Usman; Kim, Sohee; Hong, Keum-Shik

2017-01-01

For those individuals with upper-extremity amputation, a daily normal living activity is no longer possible or it requires additional effort and time. With the aim of restoring their sensory and motor functions, theoretical and technological investigations have been carried out in the field of neuroprosthetic systems. For transmission of sensory feedback, several interfacing modalities including indirect (non-invasive), direct-to-peripheral-nerve (invasive), and cortical stimulation have been applied. Peripheral nerve interfaces demonstrate an edge over the cortical interfaces due to the sensitivity in attaining cortical brain signals. The peripheral nerve interfaces are highly dependent on interface designs and are required to be biocompatible with the nerves to achieve prolonged stability and longevity. Another criterion is the selection of nerves that allows minimal invasiveness and damages as well as high selectivity for a large number of nerve fascicles. In this paper, we review the nerve-machine interface modalities noted above with more focus on peripheral nerve interfaces, which are responsible for provision of sensory feedback. The invasive interfaces for recording and stimulation of electro-neurographic signals include intra-fascicular, regenerative-type interfaces that provide multiple contact channels to a group of axons inside the nerve and the extra-neural-cuff-type interfaces that enable interaction with many axons around the periphery of the nerve. Section Current Prosthetic Technology summarizes the advancements made to date in the field of neuroprosthetics toward the achievement of a bidirectional nerve-machine interface with more focus on sensory feedback. In the Discussion section, the authors propose a hybrid interface technique for achieving better selectivity and long-term stability using the available nerve interfacing techniques. PMID:29163122

An Evaluation of Alternative Designs for a Grid Information Service

Science.gov (United States)

Smith, Warren; Waheed, Abdul; Meyers, David; Yan, Jerry; Kwak, Dochan (Technical Monitor)

2001-01-01

The Globus information service wasn't working well. There were many updates of data from Globus daemons which saturated the single server and users couldn't retrieve information. We created a second server for NASA and Alliance. Things were great on that server, but a bit slow on the other server. We needed to know exactly how the information service was being used. What were the best servers and configurations? This viewgraph presentation gives an overview of the evaluation of alternative designs for a Grid Information Service. Details are given on the workload characterization, methodology used, and the performance evaluation.

Imaging of the peripheral retina

Directory of Open Access Journals (Sweden)

Marcus Kernt

2013-01-01

Full Text Available The technical progress of the recent years has revolutionized imaging in ophthalmology. Scanning laser ophthalmoscopy (SLO, digital angiography, optical coherence tomography (OCT, and detection of fundus autofluorescence (FAF have fundamentally changed our understanding of numerous retinal and choroidal diseases. Besides the tremendous advances in macular diagnostics, there is more and more evidence that central pathologies are often directly linked to changes in the peripheral retina. This review provides a brief overview on current posterior segment imaging techniques with a special focus on the peripheral retina.

The Barriers and Causes of Building Information Modelling Usage for Interior Design Industry

Science.gov (United States)

Hamid, A. B. Abd; Taib, M. Z. Mohd; Razak, A. H. N. Abdul; Embi, M. R.

2017-12-01

Building Information Modeling (BIM) has since developed alongside the improvement in the construction industry, purposely to simulate the design, management, construction and documentation. It facilitates and monitors the construction through visualization and emphasizes on various inputs to virtually design and construct a building using specific software. This study aims to identify and elaborate barriers of BIM usage in interior design industry in Malaysia. This study is initiated with a pilot survey utilising sixteen respondents that has been randomly chosen. Respondents are attached with interior design firms that are registered by Lembaga Arkitek Malaysia (LAM). The research findings are expected to provide significant information to encourage BIM adoption among interior design firms.

The Importance of Rare Subtypes in Diagnosis and Treatment of Peripheral Neuropathy: A Review.

Science.gov (United States)

Callaghan, Brian C; Price, Raymond S; Chen, Kevin S; Feldman, Eva L

2015-12-01

Peripheral neuropathy is a prevalent condition that usually warrants a thorough history and examination but has limited diagnostic evaluation. However, rare localizations of peripheral neuropathy often require more extensive diagnostic testing and different treatments. To describe rare localizations of peripheral neuropathy, including the appropriate diagnostic evaluation and available treatments. References were identified from PubMed searches conducted on May 29, 2015, with an emphasis on systematic reviews and randomized clinical trials. Articles were also identified through the use of the authors' own files. Search terms included common rare neuropathy localizations and their causes, as well as epidemiology, pathophysiology, diagnosis, and treatment. Diffuse, nonlength-dependent neuropathies, multiple mononeuropathies, polyradiculopathies, plexopathies, and radiculoplexus neuropathies are rare peripheral neuropathy localizations that often require extensive diagnostic testing. Atypical neuropathy features, such as acute/subacute onset, asymmetry, and/or motor predominant signs, are frequently present. The most common diffuse, nonlength-dependent neuropathies are Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, multifocal motor neuropathy, and amyotrophic lateral sclerosis. Effective disease-modifying therapies exist for many diffuse, nonlength-dependent neuropathies including Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, multifocal motor neuropathy, and some paraprotein-associated demyelinating neuropathies. Vasculitic neuropathy (multiple mononeuropathy) also has efficacious treatment options, but definitive evidence of a treatment effect for IgM anti-MAG neuropathy and diabetic amyotrophy (radiculoplexus neuropathy) is lacking. Recognition of rare localizations of peripheral neuropathy is essential given the implications for diagnostic testing and treatment. Electrodiagnostic studies are an important

Peripheral myelin protein 22 alters membrane architecture

Science.gov (United States)

Mittendorf, Kathleen F.; Marinko, Justin T.; Hampton, Cheri M.; Ke, Zunlong; Hadziselimovic, Arina; Schlebach, Jonathan P.; Law, Cheryl L.; Li, Jun; Wright, Elizabeth R.; Sanders, Charles R.; Ohi, Melanie D.

2017-01-01

Peripheral myelin protein 22 (PMP22) is highly expressed in myelinating Schwann cells of the peripheral nervous system. PMP22 genetic alterations cause the most common forms of Charcot-Marie-Tooth disease (CMTD), which is characterized by severe dysmyelination in the peripheral nerves. However, the functions of PMP22 in Schwann cell membranes remain unclear. We demonstrate that reconstitution of purified PMP22 into lipid vesicles results in the formation of compressed and cylindrically wrapped protein-lipid vesicles that share common organizational traits with compact myelin of peripheral nerves in vivo. The formation of these myelin-like assemblies depends on the lipid-to-PMP22 ratio, as well as on the PMP22 extracellular loops. Formation of the myelin-like assemblies is disrupted by a CMTD-causing mutation. This study provides both a biochemical assay for PMP22 function and evidence that PMP22 directly contributes to membrane organization in compact myelin. PMID:28695207

Peripheral Artery Disease

Science.gov (United States)

... pressure High blood cholesterol Coronary heart disease Stroke Metabolic syndrome Screening and Prevention Taking action to control your risk factors can help prevent or delay peripheral artery disease (P.A.D.) and its complications. Know your family history of health problems related to P.A. ...

Designing a Situational Awareness Information Display: Adopting an Affordance-Based Framework to Amplify User Experience in Environmental Interaction Design

Directory of Open Access Journals (Sweden)

Yingjie Victor Chen

2016-06-01

Full Text Available User experience remains a crucial consideration when assessing the successfulness of information visualization systems. The theory of affordances provides a robust framework for user experience design. In this article, we demonstrate a design case that employs an affordance-based framework and evaluate the information visualization display design. SolarWheels is an interactive information visualization designed for large display walls in computer network control rooms to help cybersecurity analysts become aware of network status and emerging issues. Given the critical nature of this context, the status and performance of a computer network must be precisely monitored and remedied in real time. In this study, we consider various aspects of affordances in order to amplify the user experience via visualization and interaction design. SolarWheels visualizes the multilayer multidimensional computer network issues with a series of integrated circular visualizations inspired by the metaphor of the solar system. To amplify user interaction and experience, the system provides a three-zone physical interaction that allows multiple users to interact with the system. Users can read details at different levels depending on their distance from the display. An expert evaluation study, based on a four-layer affordance framework, was conducted to assess and improve the interactive visualization design.

Risk Informed Design as Part of the Systems Engineering Process

Science.gov (United States)

Deckert, George

2010-01-01

This slide presentation reviews the importance of Risk Informed Design (RID) as an important feature of the systems engineering process. RID is based on the principle that risk is a design commodity such as mass, volume, cost or power. It also reviews Probabilistic Risk Assessment (PRA) as it is used in the product life cycle in the development of NASA's Constellation Program.

Agmatine suppresses peripheral sympathetic tone by inhibiting N-type Ca(2+) channel activity via imidazoline I2 receptor activation.

Science.gov (United States)

Kim, Young-Hwan; Jeong, Ji-Hyun; Ahn, Duck-Sun; Chung, Seungsoo

2016-08-26

Agmatine, a putative endogenous ligand of imidazoline receptors, suppresses cardiovascular function by inhibiting peripheral sympathetic tone. However, the molecular identity of imidazoline receptor subtypes and its cellular mechanism underlying the agmatine-induced sympathetic suppression remains unknown. Meanwhile, N-type Ca(2+) channels are important for the regulation of NA release in the peripheral sympathetic nervous system. Therefore, it is possible that agmatine suppresses NA release in peripheral sympathetic nerve terminals by inhibiting Ca(2+) influx through N-type Ca(2+) channels. We tested this hypothesis by investigating agmatine effect on electrical field stimulation (EFS)-evoked contraction and NA release in endothelium-denuded rat superior mesenteric arterial strips. We also investigated the effect of agmatine on the N-type Ca(2+) current in superior cervical ganglion (SCG) neurons in rats. Our study demonstrates that agmatine suppresses peripheral sympathetic outflow via the imidazoline I2 receptor in rat mesenteric arteries. In addition, the agmatine-induced suppression of peripheral vascular sympathetic tone is mediated by modulating voltage-dependent N-type Ca(2+) channels in sympathetic nerve terminals. These results suggest a potential cellular mechanism for the agmatine-induced suppression of peripheral sympathetic tone. Furthermore, they provide basic and theoretical information regarding the development of new agents to treat hypertension. Copyright © 2016 Elsevier Inc. All rights reserved.

Peripheral Osteoma of the Mandibular Notch: Report of a Case

International Nuclear Information System (INIS)

Iwai, Toshinori; Izumi, Toshiharu; Baba, Junichi; Maegawa, Jiro; Mitsudo, Kenji; Tohnai, Iwai

2013-01-01

Osteoma is a benign, slow-growing osteogenic tumor that sometimes arises from the craniomaxillofacial region, such as the sinus, temporal or jaw bones. Osteoma consists of compact or cancellous bone that may be peripheral, central or extraskeletal type. Peripheral osteoma arises from the periosteum and is commonly a unilateral, pedunculated mushroom-like mass. Peripheral osteoma of the mandible is relatively uncommon, and peripheral osteoma of the mandibular notch is extremely rare, although many cases arise from the mandibular body, angle, condyle, or coronoid process. We report here an unusual peripheral osteoma of the mandibular notch in a 78-year-old nonsyndromic female

Building information modeling in the architectural design phases

DEFF Research Database (Denmark)

Hermund, Anders

2009-01-01

The overall economical benefits of Building Information Modeling are generally comprehensible, but are there other problems with the implementation of BIM as a formulized system in a field that ultimately is dependant on a creative input? Is optimization and economic benefit really contributing...... with an architectural quality? In Denmark the implementation of the digital working methods related to BIM has been introduced by government law in 2007. Will the important role of the architect as designer change in accordance with these new methods, and does the idea of one big integrated model represent a paradox...... in relation to designing? The BIM mindset requires changes on many levels....

Usability and Visual Communication for Southern California Tsunami Evacuation Information: The importance of information design in disaster risk management

Science.gov (United States)

Jaenichen, C.; Schandler, S.; Wells, M.; Danielsen, T.

2015-12-01

Evacuation behavior, including participation and response, is rarely an individual and isolated process and the outcomes are usually systemic. Ineffective evacuation information can easily attribute to delayed evacuation response. Delays increase demands on already extended emergency personal, increase the likelihood of traffic congestion, and can cause harm to self and property. From an information design perspective, addressing issues in cognitive recall and emergency psychology, this case study examines evacuation messaging including written, audio, and visual presentation of information, and describes the application of design principles and role of visual communication for Southern California tsunami evacuation outreach. The niche of this project is the inclusion of cognitive processing as the driving influence when making formal design decisions and measurable data from a 4-year cognitive recall study to support the solution. Image included shows a tsunami evacaution map before and after the redesign.

Somatosensory evoked potentials in the assessment of peripheral neuropathies: Commented results of a survey among French-speaking practitioners and recommendations for practice.

Science.gov (United States)

Morizot-Koutlidis, R; André-Obadia, N; Antoine, J-C; Attarian, S; Ayache, S S; Azabou, E; Benaderette, S; Camdessanché, J-P; Cassereau, J; Convers, P; d'Anglejean, J; Delval, A; Durand, M-C; Etard, O; Fayet, G; Fournier, E; Franques, J; Gavaret, M; Guehl, D; Guerit, J-M; Krim, E; Kubis, N; Lacour, A; Lozeron, P; Mauguière, F; Merle, P-E; Mesrati, F; Mutschler, V; Nicolas, G; Nordine, T; Pautot, V; Péréon, Y; Petiot, P; Pouget, J; Praline, J; Salhi, H; Trébuchon, A; Tyvaert, L; Vial, C; Zola, J-M; Zyss, J; Lefaucheur, J-P

2015-05-01

Somatosensory evoked potentials (SSEPs) are increasingly performed for the assessment of peripheral neuropathies, but no practical guidelines have yet been established in this specific application. To determine the relevant indication criteria and optimal technical parameters for SSEP recording in peripheral neuropathy investigation. A survey was conducted among the French-speaking practitioners with experience of SSEP recording in the context of peripheral neuropathies. The results of the survey were analyzed and discussed to provide recommendations for practice. SSEPs appear to be a second-line test when electroneuromyographic investigation is not sufficiently conclusive, providing complementary and valuable information on central and proximal peripheral conduction in the somatosensory pathways. Guidelines for a standardized recording protocol, including the various parameters to be measured, are proposed. We hope that these proposals will help to recognize the value of this technique in peripheral neuropathy assessment in clinical practice. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Peripheral Primitive Neuroectodermal Tumor of the Stomach: A Case Report

International Nuclear Information System (INIS)

Park, Woon Ju; Cho, June Sik; Shin, Kyung Sook; Jeong, Hyung Yong; Noh; Seung Moo; Song, Kyu Sang

2010-01-01

Peripheral primitive neuroectodermal tumors (peripheral PNETs) are very rare and highly aggressive soft tissue malignancies originating from the neural crest. To the best of our knowledge, only a few cases of peripheral PNETs of the stomach have been reported in the literature. We report a case of large peripheral primitive neuroectodermal tumor of the stomach with MDCT findings in a 22-year-old man presenting epigastric pain and vomiting

Information system and website design to support theautomotive manufacture ERP system

Science.gov (United States)

Amran, T. G.; Azmi, N.; Surjawati, A. A.

2017-12-01

This research is to create an on-time production system design with Heijunka model so that the product diversity for all models could meet time and capacity requirements, own production flexibility, high quality, meet the customers’ demands, realistic in production as well as creating a web-based local components’ order information system that supports the Enterprise Resource Planning (ERP) system. The Heijunka model for equalization with heuristic and stochastic model has been implemented for productions up to 3000 units by implementing Suzuki International Manufacturing. The inefficiency in the local order information system demanded the need for a new information system design that is integrated in ERP. Kaizen needs to be done is the Supplier Network that all vendors can download and utilize those data to deliver the components to the company and for vendors’ internal uses as well. The model design is presumed effective where the model is able to be utilized as a solution so that the production can run according to the schedule and presumed efficient were the model is able to show the reduction of loss time and stock.

Patients' feelings and experiences during and after peripheral percutaneous transluminal angioplasty

International Nuclear Information System (INIS)

Lundén, Maud; Lundgren, Solveig M.; Persson, Lars-Olof; Lepp, Margret

2015-01-01

Background: Peripheral Arterial Disease (PAD) often caused by atherosclerosis is a major health care issue worldwide. Percutaneous Transluminal Angioplasty (PTA) on the lower limb is a common procedure used to enhance peripheral circulation. With an increasing number of individuals acquiring peripheral PTA treatment and with an increased focus on patient centred care, there is a need to find out more about patients' feelings and thoughts of undergoing PTA. Aim: The aim was to identify patients who are predominantly anxious or calm during and after peripheral PTA and to explore reasons for these feelings. Method: The study includes 51 patients who received PTA treatment in western Sweden. Findings: Seventy-eight percent of the patients rated themselves as calm after the PTA. The analysed interviews resulted in two themes: reasons for feelings of calmness and reasons for feelings of anxiety. Conclusion: In order to feel calm during and after the PTA, information given prior to the PTA needs to be comprehensive and consistent with the actual situation at the angiography suite. The dialogue with the physician and the radiographers was considered valuable, as was the ability to follow the procedure on the image screen. It is concluded that a thorough dialogue with the physician in a calm setting after the PTA is important for the patients' ability to foresee and plan for the future. Moreover, there is a need to find ways to improve analgesic routines regarding assessment and evaluation in connection with PTA treatment as pain is shown to increase anxiety

Peripheral T-Cell Lymphoma

Science.gov (United States)

... Non-Hodgkin Lymphoma Peripheral T-Cell Lymphoma Primary Central Nervous System Lymphoma T-Cell Lymphoma Transformed Mycosis Fungoides Waldenstrom Macroglobulinemia Young Adult Lymphoma Overview Treatment Options Relapsed/Refractory Long-term ...

Navigation and Alignment Aids Concept of Operations and Supplemental Design Information. Revision A

Science.gov (United States)

Kelly, Sean M.; Cryan, Scott P.

2016-01-01

The IDSS Navigation and Alignment Aids Concept of Operations and Supplemental Design Information document provides supplemental information to the IDSS IDD. The guide provides insight into the navigation and alignment aids design, and how those aids can be utilized by incoming vehicles for proximity operations and docking. The navigation aids are paramount to successful docking.

Peripheral facial palsy in children.

Science.gov (United States)

Yılmaz, Unsal; Cubukçu, Duygu; Yılmaz, Tuba Sevim; Akıncı, Gülçin; Ozcan, Muazzez; Güzel, Orkide

2014-11-01

The aim of this study is to evaluate the types and clinical characteristics of peripheral facial palsy in children. The hospital charts of children diagnosed with peripheral facial palsy were reviewed retrospectively. A total of 81 children (42 female and 39 male) with a mean age of 9.2 ± 4.3 years were included in the study. Causes of facial palsy were 65 (80.2%) idiopathic (Bell palsy) facial palsy, 9 (11.1%) otitis media/mastoiditis, and tumor, trauma, congenital facial palsy, chickenpox, Melkersson-Rosenthal syndrome, enlarged lymph nodes, and familial Mediterranean fever (each 1; 1.2%). Five (6.1%) patients had recurrent attacks. In patients with Bell palsy, female/male and right/left ratios were 36/29 and 35/30, respectively. Of them, 31 (47.7%) had a history of preceding infection. The overall rate of complete recovery was 98.4%. A wide variety of disorders can present with peripheral facial palsy in children. Therefore, careful investigation and differential diagnosis is essential. © The Author(s) 2013.

Peripheral doses from pediatric IMRT

International Nuclear Information System (INIS)

Klein, Eric E.; Maserang, Beth; Wood, Roy; Mansur, David

2006-01-01

Peripheral dose (PD) data exist for conventional fields (≥10 cm) and intensity-modulated radiotherapy (IMRT) delivery to standard adult-sized phantoms. Pediatric peripheral dose reports are limited to conventional therapy and are model based. Our goal was to ascertain whether data acquired from full phantom studies and/or pediatric models, with IMRT treatment times, could predict Organ at Risk (OAR) dose for pediatric IMRT. As monitor units (MUs) are greater for IMRT, it is expected IMRT PD will be higher; potentially compounded by decreased patient size (absorption). Baseline slab phantom peripheral dose measurements were conducted for very small field sizes (from 2 to 10 cm). Data were collected at distances ranging from 5 to 72 cm away from the field edges. Collimation was either with the collimating jaws or the multileaf collimator (MLC) oriented either perpendicular or along the peripheral dose measurement plane. For the clinical tests, five patients with intracranial or base of skull lesions were chosen. IMRT and conventional three-dimensional (3D) plans for the same patient/target/dose (180 cGy), were optimized without limitation to the number of fields or wedge use. Six MV, 120-leaf MLC Varian axial beams were used. A phantom mimicking a 3-year-old was configured per Center for Disease Control data. Micro (0.125 cc) and cylindrical (0.6 cc) ionization chambers were appropriated for the thyroid, breast, ovaries, and testes. The PD was recorded by electrometers set to the 10 -10 scale. Each system set was uniquely calibrated. For the slab phantom studies, close peripheral points were found to have a higher dose for low energy and larger field size and when MLC was not deployed. For points more distant from the field edge, the PD was higher for high-energy beams. MLC orientation was found to be inconsequential for the small fields tested. The thyroid dose was lower for IMRT delivery than that predicted for conventional (ratio of IMRT/cnventional ranged from

Foveal and peripheral fields of vision influences perceptual skill in anticipating opponents' attacking position in volleyball.

Science.gov (United States)

Schorer, Jörg; Rienhoff, Rebecca; Fischer, Lennart; Baker, Joseph

2013-09-01

The importance of perceptual-cognitive expertise in sport has been repeatedly demonstrated. In this study we examined the role of different sources of visual information (i.e., foveal versus peripheral) in anticipating volleyball attack positions. Expert (n = 11), advanced (n = 13) and novice (n = 16) players completed an anticipation task that involved predicting the location of volleyball attacks. Video clips of volleyball attacks (n = 72) were spatially and temporally occluded to provide varying amounts of information to the participant. In addition, participants viewed the attacks under three visual conditions: full vision, foveal vision only, and peripheral vision only. Analysis of variance revealed significant between group differences in prediction accuracy with higher skilled players performing better than lower skilled players. Additionally, we found significant differences between temporal and spatial occlusion conditions. Both of those factors interacted separately, but not combined with expertise. Importantly, for experts the sum of both fields of vision was superior to either source in isolation. Our results suggest different sources of visual information work collectively to facilitate expert anticipation in time-constrained sports and reinforce the complexity of expert perception.

Distribution of Peripheral Memory T Follicular Helper Cells in Patients with Schistosomiasis Japonica.

Directory of Open Access Journals (Sweden)

Xiaojun Chen

Full Text Available Schistosomiasis is a helminthic disease that affects more than 200 million people. An effective vaccine would be a major step towards eliminating the disease. Studies suggest that T follicular helper (Tfh cells provide help to B cells to generate the long-term humoral immunity, which would be a crucial component of successful vaccines. Thus, understanding the biological characteristics of Tfh cells in patients with schistosomiasis, which has never been explored, is essential for vaccine design.In this study, we investigated the biological characteristics of peripheral memory Tfh cells in schistosomiasis patients by flow cytometry. Our data showed that the frequencies of total and activated peripheral memory Tfh cells in patients were significantly increased during Schistosoma japonicum infection. Moreover, Tfh2 cells, which were reported to be a specific subpopulation to facilitate the generation of protective antibodies, were increased more greatly than other subpopulations of total peripheral memory Tfh cells in patients with schistosomiasis japonica. More importantly, our result showed significant correlations of the percentage of Tfh2 cells with both the frequency of plasma cells and the level of IgG antibody. In addition, our results showed that the percentage of T follicular regulatory (Tfr cells was also increased in patients with schistosomiasis.Our report is the first characterization of peripheral memory Tfh cells in schistosomasis patients, which not only provides potential targets to improve immune response to vaccination, but also is important for the development of vaccination strategies to control schistosomiasis.

21 CFR 882.5870 - Implanted peripheral nerve stimulator for pain relief.

Science.gov (United States)

2010-04-01

....5870 Implanted peripheral nerve stimulator for pain relief. (a) Identification. An implanted peripheral nerve stimulator for pain relief is a device that is used to stimulate electrically a peripheral nerve... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Implanted peripheral nerve stimulator for pain...

Peripheral dose outside applicators in electron beams

International Nuclear Information System (INIS)

Chow, James C L; Grigorov, Grigor N

2006-01-01

The peripheral dose outside the applicators in electron beams was studied using a Varian 21 EX linear accelerator. To measure the peripheral dose profiles and point doses for the applicator, a solid water phantom was used with calibrated Kodak TL films. Peak dose spot was observed in the 4 MeV beam outside the applicator. The peripheral dose peak was very small in the 6 MeV beam and was ignorable at higher energies. Using the 10 x 10 cm 2 cutout and applicator, the dose peak for the 4 MeV beam was about 12 cm away from the field central beam axis (CAX) and the peripheral dose profiles did not change with depths measured at 0.2, 0.5 and 1 cm. The peripheral doses and profiles were further measured by varying the angle of obliquity, cutout and applicator size for the 4 MeV beam. The local peak dose was increased with about 3% per degree angle of obliquity, and was about 1% of the prescribed dose (angle of obliquity equals zero) at 1 cm depth in the phantom using the 10 x 10 cm 2 cutout and applicator. The peak dose position was also shifted 7 mm towards the CAX when the angle of obliquity was increased from 0 to 15 deg. (note)

Design Strategy of Information Construction Based on User Participation

OpenAIRE

Gao Jundong

2017-01-01

In the design of the Internet products, the information construction is one of the important factors to determine that whether a product is friendly. It is a challenge for every information architect to discover new innovations on the basis of established user habits. In practice, we often found that the development of many new functions did not meet the needs of users and many functions would be improved by users themselves, the fact of which shows the strong desire of users to participate i...

Intraoperative digital angiography: Peripheral vascular applications

International Nuclear Information System (INIS)

Bell, K.; Reifsteck, J.E.; Binet, E.F.; Fleisher, H.J.

1986-01-01

Intraoperative digital angiography is the procedure of choice for the peripheral vascular surgeon who wishes to evaluate his results before terminating anesthesia. Two operating suites at the John L. McClellan Memorial Veterans Hospital are equipped with permanent ceiling-mounted Philips C-arm fluoroscopes and share an ADAC 4100 digital angiographic system. In the last 18 months, 40 peripheral vascular intraoperative digital angiographic procedures have been performed, in all but two cases using direct arterial puncture. In 65% of cases, the intraoperative study showed no significant abnormality. In 12.5%, minor abnormalities not requiring reoperation were seen. In 22.5% of cases, the intraoperative digital angiogram revealed a significant abnormality requiring immediate operative revision. None of the patients who underwent reoperation experienced postoperative sequelae. Intraoperative digital angiography is useful in identifying complications of peripheral vascular operations

Designing Health Websites Based on Users’ Web-Based Information-Seeking Behaviors: A Mixed-Method Observational Study

Science.gov (United States)

Pang, Patrick Cheong-Iao; Verspoor, Karin; Pearce, Jon

2016-01-01

Background Laypeople increasingly use the Internet as a source of health information, but finding and discovering the right information remains problematic. These issues are partially due to the mismatch between the design of consumer health websites and the needs of health information seekers, particularly the lack of support for “exploring” health information. Objective The aim of this research was to create a design for consumer health websites by supporting different health information–seeking behaviors. We created a website called Better Health Explorer with the new design. Through the evaluation of this new design, we derive design implications for future implementations. Methods Better Health Explorer was designed using a user-centered approach. The design was implemented and assessed through a laboratory-based observational study. Participants tried to use Better Health Explorer and another live health website. Both websites contained the same content. A mixed-method approach was adopted to analyze multiple types of data collected in the experiment, including screen recordings, activity logs, Web browsing histories, and audiotaped interviews. Results Overall, 31 participants took part in the observational study. Our new design showed a positive result for improving the experience of health information seeking, by providing a wide range of information and an engaging environment. The results showed better knowledge acquisition, a higher number of page reads, and more query reformulations in both focused and exploratory search tasks. In addition, participants spent more time to discover health information with our design in exploratory search tasks, indicating higher engagement with the website. Finally, we identify 4 design considerations for designing consumer health websites and health information–seeking apps: (1) providing a dynamic information scope; (2) supporting serendipity; (3) considering trust implications; and (4) enhancing interactivity

Evaluation of patients radiation dose from computed tomography during lower peripheral angiography procedure

International Nuclear Information System (INIS)

Khlafallah, Leena Ahmed Ali

2015-09-01

The purpose of this study was to evaluate patient radiation doses in lower peripheral angiography CT examinations in Sudan. Survey was conducted in four major hospitals which almost carry out lower peripheral angiography procedures in Sudan at the time of study. All hospitals were equipped with 64 slices multi detectors CT from Toshiba (Japan). The total number of patients was 74. Information on patient's genders and ages, exposure technique factors and radiation dose were collected. The procedures performed in multi phases, up to five phases covering part of the abdomen region, which can make patients exposure reasonably high. CTDI values in the different phases ranged between (13-30) mGy. The total DLP in the four hospitals were 6888.75, 5065.05, 6608.88 and 5754.9 mGy.cm. This study provided first survey for patient dose during lower peripheral angiography procedures in Sudan. Taking into account that the CT machines were similar: the variation between patient's DLP and CTDI values in the different hospitals indicated the need of optimization of radiation protection. Staff training and awareness on factors affecting patient dose are essential.(Author)

Rationale and design of a randomized double-blind clinical trial in breast cancer: dextromethorphan in chemotherapy-induced peripheral neuropathy.

Science.gov (United States)

Martin, Elodie; Morel, Véronique; Joly, Dominique; Villatte, Christine; Delage, Noémie; Dubray, Claude; Pereira, Bruno; Pickering, Gisèle

2015-03-01

Anti-cancer chemotherapy often induces peripheral neuropathy and consequent cognitive and quality of life impairment. Guidelines recommend antiepileptics or antidepressants but their efficacy is limited.Dextromethorphan, a N-methyl-D-aspartate receptor antagonist, has shown its efficacy in painful diabetic neuropathy and in post-operative pain but has not been studied in chemotherapy-induced peripheral neuropathy. This clinical trial evaluates the effect of dextromethorphan on pain, cognition and quality of life in patients who suffer from neuropathic pain induced by chemotherapy for breast cancer. It also assesses the impact of dextromethorphan genetic polymorphism on analgesia. This trial is a randomized, placebo-controlled, double-blind clinical study in two parallel groups (NCT02271893). It includes 40 breast cancer patients suffering from chemotherapy-induced peripheral neuropathy. They are randomly allocated to dextromethorphan (maximal dose 90 mg/day) or placebo for 4 weeks. The primary endpoint is pain intensity measured after 4 weeks of treatment on a (0-10) Numeric Pain Rating Scale. Secondary outcomes include assessment of neuropathic pain, cognitive function, anxiety/depression, sleep and quality of life. Data analysis is performed using mixed models and the tests are two-sided, with a type I error set at α=0.05. Considering the poor efficacy of available drugs in chemotherapy-induced neuropathic pain, dextromethorphan may be a valuable therapeutic option. Pharmacogenetics may provide predictive factors of dextromethorphan response in patients suffering from breast cancer. Copyright © 2015 Elsevier Inc. All rights reserved.

Beyond Information Architecture: A Systems Integration Approach to Web-site Design

Directory of Open Access Journals (Sweden)

Krisellen Maloney

2017-09-01

Full Text Available Users' needs and expectations regarding access to information have fundamentally changed, creating a disconnect between how users expect to use a library Web site and how the site was designed. At the same time, library technical infrastructures include legacy systems that were not designedf or the Web environment. The authors propose a framework that combines elements of information architecture with approaches to incremental system design and implementation. The framework allows for the development of a Web site that is responsive to changing user needs, while recognizing the need for libraries to adopt a cost-effective approach to implementation and maintenance.

Management of peripheral facial nerve palsy

OpenAIRE

Finsterer, Josef

2008-01-01

Peripheral facial nerve palsy (FNP) may (secondary FNP) or may not have a detectable cause (Bell?s palsy). Three quarters of peripheral FNP are primary and one quarter secondary. The most prevalent causes of secondary FNP are systemic viral infections, trauma, surgery, diabetes, local infections, tumor, immunological disorders, or drugs. The diagnosis of FNP relies upon the presence of typical symptoms and signs, blood chemical investigations, cerebro-spinal-fluid-investigations, X-ray of the...

Examining the central and peripheral processes of written word production through meta-analysis

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Jeremy ePurcell

2011-10-01

Full Text Available Producing written words requires central cognitive processes (such as orthographic long-term and working memory as well as more peripheral processes responsible for generating the motor actions needed for producing written words in a variety of formats (handwriting, typing, etc.. In recent years, various functional neuroimaging studies have examined the neural substrates underlying the central and peripheral processes of written word production. This study provides the first quantitative meta-analysis of these studies by applying Activation Likelihood Estimation methods (Turkeltaub et al., 2002. For alphabet languages, we identified 11 studies (with a total of 17 experimental contrasts that had been designed to isolate central and/or peripheral processes of word spelling (total number of participants = 146. Three ALE meta-analyses were carried out. One involved the complete set of 17 contrasts; two others were applied to subsets of contrasts to distinguish the neural substrates of central from peripheral processes. These analyses identified a network of brain regions reliably associated with the central and peripheral processes of word spelling. Among the many significant results, is the finding that the regions with the greatest correspondence across studies were in the left inferior temporal/fusiform gyri and left inferior frontal gyrus. Furthermore, although the angular gyrus has traditionally been identified as a key site within the written word production network, none of the meta-analyses found it to be a consistent site of activation, identifying instead a region just superior/medial to the left angular gyrus in the left posterior intraparietal sulcus. In general these meta-analyses and the discussion of results provide a valuable foundation upon which future studies that examine the neural basis of written word production can build.

Processes in construction of failure management expert systems from device design information

Science.gov (United States)

Malin, Jane T.; Lance, Nick

1987-01-01

This paper analyzes the tasks and problem solving methods used by an engineer in constructing a failure management expert system from design information about the device to te diagnosed. An expert test engineer developed a trouble-shooting expert system based on device design information and experience with similar devices, rather than on specific expert knowledge gained from operating the device or troubleshooting its failures. The construction of the expert system was intensively observed and analyzed. This paper characterizes the knowledge, tasks, methods, and design decisions involved in constructing this type of expert system, and makes recommendations concerning tools for aiding and automating construction of such systems.

Conceptual design of the national nuclear emergency management information system

International Nuclear Information System (INIS)

Wang Xingyu; Shi Zhongqi

2003-01-01

A Conceptual Design of the National Nuclear Emergency Management Information System was brought forward in this paper, based on the summarization of some emergency management information systems used in China and some other countries. The conceptual system should have four basic characteristics, that are (1) a graphic displaying and querying interface based on GIS (2) data and results shared with the assessment software of nuclear accident (3) a complete set of databases and (4) the capability of on-line data receiving or real-time distributing of the commands and information for emergency response

Volunteered Geographic Information System Design: Project and Participation Guidelines

Directory of Open Access Journals (Sweden)

José-Pablo Gómez-Barrón

2016-07-01

Full Text Available This article sets forth the early phases of a methodological proposal for designing and developing Volunteered Geographic Information (VGI initiatives based on a system perspective analysis in which the components depend and interact dynamically among each other. First, it focuses on those characteristics of VGI projects that present different goals and modes of organization, while using a crowdsourcing strategy to manage participants and contributions. Next, a tool is developed in order to design the central crowdsourced processing unit that is best suited for a specific project definition, associating it with a trend towards crowd-based or community-driven approaches. The design is structured around the characterization of different ways of participating, and the task cognitive demand of working on geo-information management, spatial problem solving and ideation, or knowledge acquisition. Then, the crowdsourcing process design helps to identify what kind of participants are needed and outline subsequent engagement strategies. This is based on an analysis of differences among volunteers’ participatory behaviors and the associated set of factors motivating them to contribute, whether on a crowd or community-sourced basis. From a VGI system perspective, this paper presents a set of guidelines and methodological steps in order to align project goals, processes and volunteers and thus successfully attract participation. This methodology helps establish the initial requirements for a VGI system, and, in its current state, it mainly focuses on two components of the system: project and participants.

Normal and sonographic anatomy of selected peripheral nerves. Part II: Peripheral nerves of the upper limb

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Berta Kowalska

2012-06-01

Full Text Available The ultrasonographic examination is frequently used for imaging peripheral nerves. It serves to supplement the physical examination, electromyography, and magnetic resonance imaging. As in the case of other USG imaging studies, the examination of peripheral nerves is non-invasive, well-tolerated by patients, and relatively inexpensive. Part I of this article series described in detail the characteristic USG picture of peripheral nerves and the proper examination technique, following the example of the median nerve. This nerve is among the most often examined peripheral nerves of the upper limb. This part presents describes the normal anatomy and ultrasound picture of the remaining large nerve branches in the upper extremity and neck – the spinal accessory nerve, the brachial plexus, the suprascapular, axillary, musculocutaneous, radial and ulnar nerves. Their normal anatomy and ultrasonographic appearance have been described, including the division into individual branches. For each of them, specific reference points have been presented, to facilitate the location of the set trunk and its further monitoring. Sites for the application of the ultrasonographic probe at each reference point have been indicated. In the case of the ulnar nerve, the dynamic component of the examination was emphasized. The text is illustrated with images of probe positioning, diagrams of the normal course of the nerves as well as a series of ultrasonographic pictures of normal nerves of the upper limb. This article aims to serve as a guide in the ultrasound examination of the peripheral nerves of the upper extremity. It should be remembered that a thorough knowledge of the area’s topographic anatomy is required for this type of examination.

Peripheral Atherectomy: Applications and Techniques.

Science.gov (United States)

Mittleider, Derek; Russell, Erich

2016-06-01

Peripheral atherectomy is a class of procedures that is rapidly increasing in volume. Multiple classes of devices exist, and newer variants are added to the market annually. The devices see wide application for de novo lesions, in-stent restenosis, and adjunctive therapy for drug-coated balloons. The body of evidence supporting atherectomy is less robust than for many other peripheral therapies. The frequency and severity of complications from atherectomy can be significant compared with angioplasty and stenting, and familiarity with preventative and bailout techniques is essential for the interventionalist. Copyright © 2016 Elsevier Inc. All rights reserved.

Method and simulation program informed decisions in the early stages of building design

DEFF Research Database (Denmark)

Petersen, Steffen; Svendsen, Svend

2010-01-01

variations. The program then presents the output in a way that enables designers to make informed decisions. The method and the program reduce the need for design iterations, reducing time consumption and construction costs, to obtain the intended energy performance and indoor environment....... for making informed decisions in the early stages of building design to fulfil performance requirements with regard to energy consumption and indoor environment. The method is operationalised in a program that utilises a simple simulation program to make performance predictions of user-defined parameter......The early stages of building design include a number of decisions which have a strong influence on the performance of the building throughout the rest of the process. It is therefore important that designers are aware of the consequences of these design decisions. This paper presents a method...

Imaging of a glioma using peripheral benzodiazepine receptor ligands

Energy Technology Data Exchange (ETDEWEB)

Starosta-Rubinstein, S.; Ciliax, B.J.; Penney, J.B.; McKeever, P.; Young, A.B.

1987-02-01

Two types of benzodiazepine receptors have been demonstrated in mammalian tissues, one which is localized on neuronal elements in brain and the other, on glial cells and in peripheral tissues such as kidney. In vivo administration of /sup 3/H-labeled PK 11195 (1-(2-chlorophenyl-N-methyl-N-(1-methylpropyl)-3-isoquinoline carboxamide) or (/sup 3/H)flunitrazepam with 5 mg of clonazepam per kg to rats with intracranial C6 gliomas resulted in high levels of tritiated-drug binding to the tumor as shown by quantitative autoradiography. Pharmacological studies indicated that the bound drugs labeled the peripheral benzodiazepine binding site. Binding to the peripheral benzodiazepine site was confirmed primarily to malignant cells with little binding to adjacent normal brain tissue or to necrotic tissue. Tumor cell binding was completely inhibited by preadministration of the peripheral benzodiazepine blocking agent PK 11195 at 5 mg/kg. The centrally selective benzodiazepine ligand clonazepam had no effect on PK 11195 binding to the tumor cells. When binding to other tumor cell lines grown in nude mice and nude athymic rats was evaluated, little or no peripheral benzodiazepine binding was detected on human pheochromocytoma (RN1) and neuroblastoma (SK-N-MC, SK-N-SH) tumor cells, respectively. However, high densities of peripheral benzodiazepine binding sites were observed on tumors derived from a human glioma cell line (ATCC HTB 14, U-87 MG). The presence of high concentrations of specific peripheral benzodiazepine receptors on glial tumors suggests that human primary central nervous system tumors could be imaged and diagnosed using peripheral benzodiazepine ligands labeled with positron- or gamma-emitting isotopes.

Developments in Participatory Design of Health Information Technology

DEFF Research Database (Denmark)

Kanstrup, Anne Marie; Madsen, Jacob; Nøhr, Christian

2017-01-01

The landscape of Participatory Design (PD) of Health Information Technology (HIT) is diverse and constantly evolving. This paper reviews the publications in the proceedings from the Participatory Design Conferences (PDCs) that have been held every two years since 1990. We used the Matrix Method...... procedures, records, secondary healthcare and health professionals. However, the analysis also shows a development from a primary focus on health workers and hospitals to a recent attention on HIT in everyday life and PD with patients, relatives, neighbourhoods and citizens in general. Additionally......, the review shows a growing number of PD methods being applied. This paper concludes that research on PD and HIT appears to be maturing and developing with ongoing technological and societal development....

Hospital information system: reusability, designing, modelling, recommendations for implementing.

Science.gov (United States)

Huet, B

1998-01-01

The aims of this paper are to precise some essential conditions for building reuse models for hospital information systems (HIS) and to present an application for hospital clinical laboratories. Reusability is a general trend in software, however reuse can involve a more or less part of design, classes, programs; consequently, a project involving reusability must be precisely defined. In the introduction it is seen trends in software, the stakes of reuse models for HIS and the special use case constituted with a HIS. The main three parts of this paper are: 1) Designing a reuse model (which objects are common to several information systems?) 2) A reuse model for hospital clinical laboratories (a genspec object model is presented for all laboratories: biochemistry, bacteriology, parasitology, pharmacology, ...) 3) Recommendations for generating plug-compatible software components (a reuse model can be implemented as a framework, concrete factors that increase reusability are presented). In conclusion reusability is a subtle exercise of which project must be previously and carefully defined.

Importance measures and genetic algorithms for designing a risk-informed optimally balanced system

International Nuclear Information System (INIS)

Zio, Enrico; Podofillini, Luca

2007-01-01

This paper deals with the use of importance measures for the risk-informed optimization of system design and management. An optimization approach is presented in which the information provided by the importance measures is incorporated in the formulation of a multi-objective optimization problem to drive the design towards a solution which, besides being optimal from the points of view of economics and safety, is also 'balanced' in the sense that all components have similar importance values. The approach allows identifying design systems without bottlenecks or unnecessarily high-performing components and with test/maintenance activities calibrated according to the components' importance ranking. The approach is tested at first against a multi-state system design optimization problem in which off-the-shelf components have to be properly allocated. Then, the more realistic problem of risk-informed optimization of the technical specifications of a safety system of a nuclear power plant is addressed

Emotional facial expression detection in the peripheral visual field.

Directory of Open Access Journals (Sweden)

Dimitri J Bayle

Full Text Available BACKGROUND: In everyday life, signals of danger, such as aversive facial expressions, usually appear in the peripheral visual field. Although facial expression processing in central vision has been extensively studied, this processing in peripheral vision has been poorly studied. METHODOLOGY/PRINCIPAL FINDINGS: Using behavioral measures, we explored the human ability to detect fear and disgust vs. neutral expressions and compared it to the ability to discriminate between genders at eccentricities up to 40°. Responses were faster for the detection of emotion compared to gender. Emotion was detected from fearful faces up to 40° of eccentricity. CONCLUSIONS: Our results demonstrate the human ability to detect facial expressions presented in the far periphery up to 40° of eccentricity. The increasing advantage of emotion compared to gender processing with increasing eccentricity might reflect a major implication of the magnocellular visual pathway in facial expression processing. This advantage may suggest that emotion detection, relative to gender identification, is less impacted by visual acuity and within-face crowding in the periphery. These results are consistent with specific and automatic processing of danger-related information, which may drive attention to those messages and allow for a fast behavioral reaction.

Peripheral ossifying fibroma of oral cavity: histopathologic differential diagnoses.

Science.gov (United States)

Shamim, Thorakkal

2012-01-01

Peripheral ossifying fibroma is a benign neoplasm that usuallydevelops from gingiva, presenting as an exophytic smooth surfaced pink or red nodular mass that is sessile or is less frequently seen on a pedicle. From the Indian perspective, it is usually noticed in 5th-6th decades of life with female predilection. Microscopically, the tumour shows stratified squamous epithelium and highly cellular fibrous stroma, sparse endothelial proliferation with fibroblasts and dystrophic calcifications. It has to be differentiated histopathologically from pyogenic granuloma, fibroma, peripheral giant cell granuloma, peripheral odontogenic fibroma and fibrous hyperplasia. A case of peripheral ossifying fibroma of maxillary gingiva in a 55-year-old Indian woman is reported.

MRI features of tuberculosis of peripheral joints

Energy Technology Data Exchange (ETDEWEB)

Sawlani, V.; Chandra, T.; Mishra, R.N.; Aggarwal, A.; Jain, U.K.; Gujral, R.B. E-mail: gujralrb@sgpgi.ac.in

2003-10-01

The aim of this article is to present the magnetic resonance imaging (MRI) features of peripheral tubercular arthritis. The clinical presentation of peripheral tubercular arthritis is variable and simulates other chronic inflammatory arthritic disorders. MRI is a highly sensitive technique which demonstrates fine anatomical details and identifies the early changes of arthritis, which are not visible on radiographs. The MRI features of tubercular arthritis include synovitis, effusion, central and peripheral erosions, active and chronic pannus, abscess, bone chips and hypo-intense synovium. These imaging features in an appropriate clinical setting may help in the diagnosis of tubercular arthritis. Early diagnosis and treatment can effectively eliminate the long-term morbidity of joints affected by tuberculosis.

MRI features of tuberculosis of peripheral joints

International Nuclear Information System (INIS)

Sawlani, V.; Chandra, T.; Mishra, R.N.; Aggarwal, A.; Jain, U.K.; Gujral, R.B.

2003-01-01

The aim of this article is to present the magnetic resonance imaging (MRI) features of peripheral tubercular arthritis. The clinical presentation of peripheral tubercular arthritis is variable and simulates other chronic inflammatory arthritic disorders. MRI is a highly sensitive technique which demonstrates fine anatomical details and identifies the early changes of arthritis, which are not visible on radiographs. The MRI features of tubercular arthritis include synovitis, effusion, central and peripheral erosions, active and chronic pannus, abscess, bone chips and hypo-intense synovium. These imaging features in an appropriate clinical setting may help in the diagnosis of tubercular arthritis. Early diagnosis and treatment can effectively eliminate the long-term morbidity of joints affected by tuberculosis

Contrast-enhanced peripheral MRA. Technique and contrast agents

International Nuclear Information System (INIS)

Nielsen, Yousef W.; Thomsen, Henrik S.

2012-01-01

In the last decade contrast-enhanced magnetic resonance angiography (CE-MRA) has gained wide acceptance as a valuable tool in the diagnostic work-up of patients with peripheral arterial disease. This review presents current concepts in peripheral CE-MRA with emphasis on MRI technique and contrast agents. Peripheral CE-MRA is defined as an MR angiogram of the arteries from the aortic bifurcation to the feet. Advantages of CE-MRA include minimal invasiveness and lack of ionizing radiation. The basic technique employed for peripheral CE-MRA is the bolus-chase method. With this method a paramagnetic MRI contrast agent is injected intravenously and T1-weighted images are acquired in the subsequent arterial first-pass phase. In order to achieve high quality MR angiograms without interfering venous contamination or artifacts, a number of factors need to be taken into account. This includes magnetic field strength of the MRI system, receiver coil configuration, use of parallel imaging, contrast bolus timing technique, and k-space filling strategies. Furthermore, it is possible to optimize peripheral CE-MRA using venous compression techniques, hybrid scan protocols, time-resolved imaging, and steady-state MRA. Gadolinium(Gd)-based contrast agents are used for CE-MRA of the peripheral arteries. Extracellular Gd agents have a pharmacokinetic profile similar to iodinated contrast media. Accordingly, these agents are employed for first-pass MRA. Blood-pool Gd-based agents are characterized by prolonged intravascular stay, due to macromolecular structure or protein binding. These agents can be used for first-pass, as well as steady-state MRA. Some Gd-based contrast agents with low thermodynamic stability have been linked to development of nephrogenic systemic fibrosis in patients with severe renal insufficiency. Using optimized technique and a stable MRI contrast agent, peripheral CE-MRA is a safe procedure with diagnostic accuracy close to that of conventional catheter X

Associations between peripheral vertigo and gastroesophageal reflux disease.

Science.gov (United States)

Viliušytė, Edita; Macaitytė, Raminta; Vaitkus, Antanas; Rastenytė, Daiva

2015-09-01

We hypothesize that peripheral vertigo is associated with gastroesophageal reflux disease (GERD). Two mechanisms could be considered – gastric acids may directly irritate the respiratory mucosa and cause inflammation, or Helicobacter pylori (H. pylori) could be present and cause local infection. Reflux material (Hydrochloric acid (HCl) and pepsin) could get into the middle ear via Eustachian tube and affect osseous structures directly. Disturbance of ossicles could cause tinnitus, which is more common for peripheral vertigo. H. pylori could also get in the esophagus and in the upper respiratory tract via gastroesophageal reflux, and could cause tympanosclerosis and fixation of ossicles. In our study group, 120 of 153 (78.4%) patients had gastroesophageal reflux disease (GERD). Diagnostic tests of H. pylori (rapid urease test or blood antibody test) were performed for 96 of 120 (80%) patients with GERD and were found positive for 32 of 96 (33.3%) patients. Peripheral vertigo was present in 93 of 120 (77.6%) patients with GERD compared to 33 of 126 (26%) patients without GERD (χ(2)=9.016, p=0.003). H. pylori and peripheral vertigo coexisted in 26 of 126 patients (20.6%) (OR 1.36; 95% CI 0.49-3.74, p=0.55). Our study demonstrated statistically significant association between peripheral vertigo and GERD but not between peripheral vertigo and H. pylori. Further more extensive investigations are needed in order to explore our hypothesis. Copyright © 2015 Elsevier Ltd. All rights reserved.

Using a logical information model-driven design process in healthcare.

Science.gov (United States)

Cheong, Yu Chye; Bird, Linda; Tun, Nwe Ni; Brooks, Colleen

2011-01-01

A hybrid standards-based approach has been adopted in Singapore to develop a Logical Information Model (LIM) for healthcare information exchange. The Singapore LIM uses a combination of international standards, including ISO13606-1 (a reference model for electronic health record communication), ISO21090 (healthcare datatypes), SNOMED CT (healthcare terminology) and HL7 v2 (healthcare messaging). This logic-based design approach also incorporates mechanisms for achieving bi-directional semantic interoperability.

Peripheral Neuropathy: A Practical Approach to Diagnosis and Symptom Management.

Science.gov (United States)

Watson, James C; Dyck, P James B

2015-07-01

Peripheral neuropathy is one of the most prevalent neurologic conditions encountered by physicians of all specialties. Physicians are faced with 3 distinct challenges in caring for patients with peripheral neuropathy: (1) how to efficiently and effectively screen (in less than 2 minutes) an asymptomatic patient for peripheral neuropathy when they have a disorder in which peripheral neuropathy is highly prevalent (eg, diabetes mellitus), (2) how to clinically stratify patients presenting with symptoms of neuropathy to determine who would benefit from specialty consultation and what testing is appropriate for those who do not need consultation, and (3) how to treat the symptoms of painful peripheral neuropathy. In this concise review, we address these 3 common clinical scenarios. Easily defined clinical patterns of involvement are used to identify patients in need of neurologic consultation, the yield of laboratory and other diagnostic testing is reviewed for the evaluation of length-dependent, sensorimotor peripheral neuropathies (the most common form of neuropathy), and an algorithmic approach with dosing recommendations is provided for the treatment of neuropathic pain associated with peripheral neuropathy. Copyright © 2015 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

Design of an indigeous music information storage and retrieval ...

African Journals Online (AJOL)

The main aim of the study was to design an appropriate Indigenous Music Information Storage and Retrieval System for Eritrea. A quantitative approach was mainly used to obtain data from a purposefully selected sample. The qualitative approach was also used in some research stages. Methods used included document

Cyber-Informed Engineering: The Need for a New Risk Informed and Design Methodology

Energy Technology Data Exchange (ETDEWEB)

Price, Joseph Daniel [Idaho National Laboratory; Anderson, Robert Stephen [Idaho National Laboratory

2015-06-01

Current engineering and risk management methodologies do not contain the foundational assumptions required to address the intelligent adversary’s capabilities in malevolent cyber attacks. Current methodologies focus on equipment failures or human error as initiating events for a hazard, while cyber attacks use the functionality of a trusted system to perform operations outside of the intended design and without the operator’s knowledge. These threats can by-pass or manipulate traditionally engineered safety barriers and present false information, invalidating the fundamental basis of a safety analysis. Cyber threats must be fundamentally analyzed from a completely new perspective where neither equipment nor human operation can be fully trusted. A new risk analysis and design methodology needs to be developed to address this rapidly evolving threatscape.

Presenting a Framework for Evaluating and Prioritizing Risk of Information Technology Outsourcing: Perspective of Experts in Information Systems Design

Directory of Open Access Journals (Sweden)

abbas Keramati

2012-06-01

Full Text Available Information technology outsourcing projects have advantages including: reduced costs, improved service quality, creation of competitive advantage, etc. When these projects are being outsourced, lack of attention to their risks causes the lost of anticipated benefits and contributes to failure. As for the growing trend of information technology outsourcing projects in Iran, the purpose of this study is to identify the risks of information technology outsourcing projects, evaluate and prioritize them based on the perspective of experts in information systems design. For achieving these goals, key articles were reviewed and comprehensive list of 12 risk factors were identified. For prioritizing, a Fuzzy Analytical Network Process (F-ANP structure has been provided and the risk factors were laid in it. Then, by using a questionnaire, 13 experts' viewpoints were collected. The results show that the factor of "supplier" and the sub-factor of "Lack of skills of supplier in IT operations" are the most important factors for success and failure of information technology outsourcing projects in the perspective of experts in information systems design.

14 CFR 193.7 - What does it mean for the FAA to designate information as protected?

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false What does it mean for the FAA to designate... INFORMATION § 193.7 What does it mean for the FAA to designate information as protected? (a) General. When the FAA issues an order designating information as protected under this part, the FAA does not disclose...

Comparing infants' use of featural and spatiotemporal information when individuating objects in an event monitoring design

DEFF Research Database (Denmark)

Krøjgaard, Peter

. The results obtained using this design reveal that infants are more successful using spatiotemporal object information than when using featural information. However, recent studies using the less cognitively demanding event monitoring design have revealed that even younger infants are capable of object...... in the present series of experiments in which infants' use of spatiotemporal and featural information is compared directly using the less demanding event monitoring design. The results are discussed in relation to existing empirical evidence......., to what extent infants rely on spatiotemporal or featural object information when individuating objects is currently under debate. Hitherto, infants' use of spatiotemporal and featural object information has only been compared directly using the rather cognitively demanding event mapping design...

Three types of children’s informational web sites: an inventory of design conventions

NARCIS (Netherlands)

Jochmann-Mannak, Hanna; Lentz, Leo; Huibers, Theo W.C.; Sanders, Ted

2012-01-01

"Purpose: Research on Web design conventions has an almost exclusive focus on Web design for adults. There is far less knowledge about Web design for children. For the first time, an overview is presented of the current design conventions for children's informational Web sites. Method: In this study

Evaluation of Peripheral Blood Circulation Disorder in Scleroderma Patients Using an Optical Sensor with a Pressurization Mechanism.

Directory of Open Access Journals (Sweden)

Yoshiki Yamakoshi

Full Text Available Blood circulation function of peripheral blood vessels in skin dermis was evaluated employing an optical sensor with a pressurization mechanism using the blood outflow and reflow characteristics. The device contains a light source and an optical sensor. When applied to the skin surface, it first exerts the primary pressure (higher than the systolic blood pressure, causing an outflow of blood from the dermal peripheral blood vessels. After two heartbeats, the pressure is lowered (secondary pressure and blood reflows into the peripheral blood vessels. Hemoglobin concentration, which changes during blood outflow and reflow, is derived from the received light intensity using the Beer-Lambert law. This method was evaluated in 26 healthy female volunteers and 26 female scleroderma patients. In order to evaluate the blood circulation function of the peripheral blood vessels of scleroderma patients, pressurization sequence which consists of primary pressure followed by secondary pressure was adopted. Blood reflow during the first heartbeat period after applying the secondary pressure of 40mmHg was (mean±SD 0.059±0.05%mm for scleroderma patients and 0.173±0.104%mm for healthy volunteers. Blood reflow was significantly lower in scleroderma patients than in healthy volunteers (p<0.05. This result indicates that the information necessary for assessing blood circulation disorder of peripheral blood vessels in scleroderma patients is objectively obtained by the proposed method.

The clinical identification of peripheral neuropathy among older persons.

Science.gov (United States)

Richardson, James K

2002-11-01

To identify simple clinical rules for the detection of a diffuse peripheral neuropathy among older outpatients. Observational, blinded, controlled study. A tertiary-care electrodiagnostic laboratory and biomechanics laboratory. One hundred research subjects, 68 with electrodiagnostic evidence of peripheral neuropathy, between the ages of 50 and 80 years. Not applicable. One examiner, unaware of the results of electrodiagnostic testing, evaluated Achilles' and patellar reflexes, Romberg testing, semiquantified vibration, and position sense at the toe and ankle in all subjects, and unipedal stance time and the Michigan Diabetes Neuropathy Score in a subset of subjects. Significant group differences were present in all clinical measures tested. Three signs, Achilles' reflex (absent despite facilitation), vibration (128Hz tuning fork perceived for <10s), and position sense (<8/10 1-cm trials) at the toe, were the best predictors of peripheral neuropathy on both univariate and logistic regression (pseudo R(2)=.744) analyses. The presence of 2 or 3 signs versus 0 or 1 sign identified peripheral neuropathy with sensitivity, specificity, and positive and negative predictive values of 94.1%, 84.4%, 92.8%, and 87.1%, respectively. Values were similar among subgroups of subjects with and without diabetes mellitus. When other clinicians applied the technique to 12 more subjects, excellent interrater reliability regarding the presence of peripheral neuropathy (kappa=.833) and good to excellent interrater reliability for each sign (kappa range,.667-1.00) were shown. Among older persons, the presence of 2 or 3 of the 3 clinical signs strongly suggested electrodiagnostic evidence of a peripheral neuropathy, regardless of etiology. Age-related decline in peripheral nerve function need not be a barrier to the clinical recognition of a diffuse peripheral neuropathy among older persons. Copyright 2002 by the American Congress of Rehabilitation Medicine and the American Academy of

Improving emergency management through shared information processing - considerations in Emergency Operations Center design

International Nuclear Information System (INIS)

DeBusk, R.E.; Walker, J.A.

1987-01-01

An Emergency Operations Center (EOC) is a shared information processing facility. Although seemingly obvious, many EOCs are designed and operated based on other criteria. The results, measured in terms of response effectiveness, are difficult to determine. A review of some recent disasters reveals a pattern of poor performance for the EOCs involved. These conclusions are tentative because so little research has been done on the design, operation, or evaluation of emergency operations centers. The EOC is not an onsite response command post but a facility removed from the response where tactical and strategic decisions are made based on information from the response site and elsewhere. The EOC is therefore the central focus of emergency information processing and higher-level decision making. Examining existing EOCs, several common functions emerge. These functions can be described in terms of shared information processing. However, many factors impact the design and operation of EOCs. Politics, budgets, and personal ambition are only a few such factors. Examining EOC design and operation in terms of shared information processing operationalized in the seven principal functions within the EOC provides a framework for establishing principles of EOC design and operation. In the response to emergencies such as Bhopal or Chernobyl the stakes are high. Applying new techniques and technologies of management systems can improve the probability of success. This research is a beginning step - to understand how EOCs function, to define the system. Predictive or prescriptive analysis must wait until sufficient empirical data is available to complete a descriptive model for EOC operations

Peripheral neuropathy of dietary riboflavin deficiency in racing pigeons.

Science.gov (United States)

Wada, Y; Kondo, H; Itakura, C

1996-02-01

An occurrence of peripheral neuropathy in nine 14- to 55-day-old racing pigeons was documented. The predominant clinical signs were diarrhea, and leg and wing paralysis. Grossly, there was discoloration and swelling of all the peripheral nerve trunks. Microscopic lesions comprising swelling, fragmentation and demyelination of myelin sheaths, and proliferation of Schwann cells, were seen in the peripheral nerves of all birds examined. These changes were associated with moderate to severe swelling, fragmentation, atrophy and loss of axons. The peripheral nerve lesions in these cases were similar to those of dietary riboflavin deficiency in chickens. An analysis of the diet given to the pigeons indicated that the riboflavin concentration was only 0.9 mg/kg feed.

An annotated summary of the Information Model Design Procedure (IMDP)

Energy Technology Data Exchange (ETDEWEB)

Becker, S.D.

1994-05-01

This presentation documents the essential elements of the IMDP as applied at Sandia National Laboratories/New Mexico. The IMDP is an adaptation of the Natural-Language Information Analysis Methodology (NIAM) of G. M. Nijssen. The underlying purpose of both of these methodologies is to provide a formal, reproducible, and verifiable approach to specifying the information requirements of an information system. The IMDP spans the specification process from initial scoping; through verbalization of problem-domain facts, specification of constraints, and subtype analysis; and finally to application of a formal algorithm for developing a fifth-normal-form relational database design.

Effects of diabetic peripheral neuropathy on gait in vascular trans-tibial amputees.

Science.gov (United States)

Nakajima, Hiroshi; Yamamoto, Sumiko; Katsuhira, Junji

2018-07-01

Patients with diabetes often develop diabetic peripheral neuropathy, which is a distal symmetric polyneuropathy, so foot function on the non-amputated side is expected to affect gait in vascular trans-tibial amputees. However, there is little information on the kinematics and kinetics of gait or the effects of diabetic peripheral neuropathy in vascular trans-tibial amputees. This study aimed to clarify these effects, including the biomechanics of the ankle on the non-amputated side. Participants were 10 vascular trans-tibial amputees with diabetic peripheral neuropathy (group V) and 8 traumatic trans-tibial amputees (group T). Each subject's gait was analyzed at a self-selected speed using a three-dimensional motion analyzer and force plates. Ankle plantarflexion angle, heel elevation angle, and peak and impulse of anterior ground reaction force were smaller on the non-amputated side during pre-swing in group V than in group T. Center of gravity during pre-swing on the non-amputated side was lower in group V than in group T. Hip extension torque during loading response on the prosthetic side was greater in group V than in group T. These findings suggest that the biomechanical function of the ankle on the non-amputated side during pre-swing is poorer in vascular trans-tibial amputees with DPN than in traumatic trans-tibial amputees; the height of the center of gravity could not be maintained during this phase in vascular trans-tibial amputees with diabetic peripheral neuropathy. The hip joint on the prosthetic side compensated for this diminished function at the ankle during loading response. Copyright © 2018 Elsevier Ltd. All rights reserved.

Ultrasound-Guided Peripheral Intravenous Access in the Emergency Department: Patient-Centered Survey

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Keith Boniface

2011-05-01

Full Text Available Introduction: To assess characteristics, satisfaction, and disposition of emergency department (ED patients who successfully received ultrasound (US-guided peripheral intravenous (IV access. Methods: This is a prospective observational study among ED patients who successfully received US-guided peripheral IV access by ED technicians. Nineteen ED technicians were taught to use US guidance to obtain IV access. Training sessions consisted of didactic instruction and hands-on practice. The US guidance for IV access was limited to patients with difficult access. After successfully receiving an US-guided peripheral IV, patients were approached by research assistants who administered a 10-question survey. Disposition information was collected after the conclusion of the ED visit by accessing patients’ electronic medical record. Results: In total, 146 surveys were completed in patients successfully receiving US-guided IVs. Patients reported an average satisfaction with the procedure of 9.2 of 10. Forty-two percent of patients had a body mass index (BMI of greater than 30, and 17.8% had a BMI of more than 35. Sixty-two percent reported a history of central venous catheter placement. This patient population averaged 3 ED visits per year in the past year. Fifty-three percent of the patients were admitted. Conclusion: Patients requiring US-guided IVs in our ED are discharged home at the conclusion of their ED visit about half of the time. These patients reported high rates of both difficult IV access and central venous catheter placement in the past. Patient satisfaction with US-guided IVs was very high. These data support the continued use of US-guided peripheral IVs in this patient population. [West J Emerg Med. 2011;12(4:475–477.

An Experimental Comparison of a Co-Design Visualizing Personal Drug Information and Patient Information Leaflets: Usability Aspects.

Science.gov (United States)

Khodambashi, Soudabeh; Haugland, Dagrun; Ellingsberg, Anette; Kottum, Hanne; Sund, Janne Kutschera; Nytrø, Øystein

2017-01-01

Providing patients with specific information about their own drugs can reduce unintentional misuse and improve compliance. Searching for information is time-consuming when information is not personalized and is written using medical vocabulary that is difficult for patients to understand. In this study we explored patient information needs regarding visualizing of drug information and interrelationships by conducting a total of four co-design workshops with patients, other users and pharmacists. We developed a prototype and drug ontology to support reasoning about drug interactions. We evaluated individual performance in finding information, understanding the drug interactions, and learning from the provided information in the prototype compared to using patient information leaflets (PILs). We concluded that interactive visualization of drug information helps individuals find information about drugs, their side effects and interactions more quickly and correctly compared to using PILs. Our study is limited to co-morbid patients with transient ischaemic attack with several chronic diseases.

Tissue-engineered spiral nerve guidance conduit for peripheral nerve regeneration.

Science.gov (United States)

Chang, Wei; Shah, Munish B; Lee, Paul; Yu, Xiaojun

2018-06-01

Recently in peripheral nerve regeneration, preclinical studies have shown that the use of nerve guidance conduits (NGCs) with multiple longitudinally channels and intra-luminal topography enhance the functional outcomes when bridging a nerve gap caused by traumatic injury. These features not only provide guidance cues for regenerating nerve, but also become the essential approaches for developing a novel NGC. In this study, a novel spiral NGC with aligned nanofibers and wrapped with an outer nanofibrous tube was first developed and investigated. Using the common rat sciatic 10-mm nerve defect model, the in vivo study showed that a novel spiral NGC (with and without inner nanofibers) increased the successful rate of nerve regeneration after 6 weeks recovery. Substantial improvements in nerve regeneration were achieved by combining the spiral NGC with inner nanofibers and outer nanofibrous tube, based on the results of walking track analysis, electrophysiology, nerve histological assessment, and gastrocnemius muscle measurement. This demonstrated that the novel spiral NGC with inner aligned nanofibers and wrapped with an outer nanofibrous tube provided a better environment for peripheral nerve regeneration than standard tubular NGCs. Results from this study will benefit for future NGC design to optimize tissue-engineering strategies for peripheral nerve regeneration. We developed a novel spiral nerve guidance conduit (NGC) with coated aligned nanofibers. The spiral structure increases surface area by 4.5 fold relative to a tubular NGC. Furthermore, the aligned nanofibers was coated on the spiral walls, providing cues for guiding neurite extension. Finally, the outside of spiral NGC was wrapped with randomly nanofibers to enhance mechanical strength that can stabilize the spiral NGC. Our nerve histological data have shown that the spiral NGC had 50% more myelinated axons than a tubular structure for nerve regeneration across a 10 mm gap in a rat sciatic nerve

Malignant Peripheral Nerve Sheath Tumour of the Maxilla

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Puja Sahai

2014-01-01

Full Text Available A 38-year-old man was diagnosed with malignant peripheral nerve sheath tumour of the maxilla. He was treated with total maxillectomy. Histopathological examination of the resected specimen revealed a close resection margin. The tumour was of high grade with an MIB-1 labelling index of almost 60%. At six weeks following the surgery, he developed local tumour relapse. The patient succumbed to the disease at five months from the time of diagnosis. The present report underlines the locally aggressive nature of malignant peripheral nerve sheath tumour of the maxilla which necessitates an early therapeutic intervention. A complete resection with clear margins is the most important prognostic factor for malignant peripheral nerve sheath tumour in the head and neck region. Adjuvant radiotherapy may be considered to improve the local control. Future research may demarcate the role of targeted therapy for patients with malignant peripheral nerve sheath tumour.

Report Of The Workshop On Nuclear Facility Design Information Examination And Verification For Safeguards

International Nuclear Information System (INIS)

Metcalf, Richard; Bean, Robert

2009-01-01

The International Atomic Energy Agency (IAEA) implements nuclear safeguards and verifies countries are compliant with their international nuclear safeguards agreements. One of the key provisions in the safeguards agreement is the requirement that the country provide nuclear facility design and operating information to the IAEA relevant to safeguarding the facility, and at a very early stage. , This provides the opportunity for the IAEA to verify the safeguards-relevant features of the facility and to periodically ensure that those features have not changed. The national authorities (State System of Accounting for and Control of Nuclear Material - SSAC) provide the design information for all facilities within a country to the IAEA. The design information is conveyed using the IAEA's Design Information Questionnaire (DIQ) and specifies: (1) Identification of the facility's general character, purpose, capacity, and location; (2) Description of the facility's layout and nuclear material form, location, and flow; (3) Description of the features relating to nuclear material accounting, containment, and surveillance; and (4) Description of existing and proposed procedures for nuclear material accounting and control, with identification of nuclear material balance areas. The DIQ is updated as required by written addendum. IAEA safeguards inspectors examine and verify this information in design information examination (DIE) and design information verification (DIV) activities to confirm that the facility has been constructed or is being operated as declared by the facility operator and national authorities, and to develop a suitable safeguards approach. Under the Next Generation Safeguards Initiative (NGSI), the National Nuclear Security Administrations (NNSA) Office of Non-Proliferation and International Security identified the need for more effective and efficient verification of design information by the IAEA for improving international safeguards in the future

Water soluble peripheral and non-peripheral tetrasubstituted zinc phthalocyanines: Synthesis, photochemistry and bovine serum albumin binding behavior

Energy Technology Data Exchange (ETDEWEB)

Çakır, Volkan; Çakır, Dilek [Department of Chemistry, Faculty of Sciences, Karadeniz Technical University, 61080 Trabzon (Turkey); Pişkin, Mehmet [Department of Food Technology, Çanakkale Vocational School of Technical Sciences, Çanakkale Onsekiz Mart University, 17100 Çanakkale (Turkey); Durmuş, Mahmut [Gebze Institute of Technology, Department of Chemistry, PO Box 141, Gebze 41400, Kocaeli (Turkey); Bıyıklıoğlu, Zekeriya, E-mail: zekeriya_61@yahoo.com [Department of Chemistry, Faculty of Sciences, Karadeniz Technical University, 61080 Trabzon (Turkey)

2014-10-15

The new peripherally and non-peripherally tetra-1,3-bis[3-(diethylamino)phenoxy]propan-2-ol substituted zinc(II) phthalocyanine complexes (2a and 3a) and their quaternized amphiphilic derivatives (2b and 3b) have been synthesized and characterized using UV–vis, FT-IR, {sup 1}H-NMR, {sup 13}C-NMR, MS spectroscopic data and elemental analysis for the first time. The quaternized complexes (2b and 3b) show excellent solubility in water and DMSO which makes them potential photosensitizers for use in photodynamic therapy (PDT) of cancer. The photochemical (singlet oxygen generation and photodegradation under light irradiation) properties of these novel phthalocyanines are investigated in dimethylsulfoxide (DMSO) for non-quaternized complexes and in DMSO, phosphate buffered solution (PBS) or PBS+triton X-100 (TX) solution for quaternized complexes. In this study, the effects of the aggregation of the molecules, quaternization, position of the substituents (peripherally or non-peripherally) and nature of the solvents (DMSO, PBS or PBS+triton X-100) on the photochemical parameters of the zinc (II) phthalocyanines are also reported. In addition, a spectroscopic investigation of the binding behavior of the quaternized zinc(II) phthalocyanine complexes to bovine serum albumin (BSA) is also presented in this work. - Highlights: • Synthesis of zinc phthalocyanines is performed. • Photophysical and photochemical properties of phthalocyanines are studied. • Photodynamic therapy studies are performed.

Water soluble peripheral and non-peripheral tetrasubstituted zinc phthalocyanines: Synthesis, photochemistry and bovine serum albumin binding behavior

International Nuclear Information System (INIS)

Çakır, Volkan; Çakır, Dilek; Pişkin, Mehmet; Durmuş, Mahmut; Bıyıklıoğlu, Zekeriya

2014-01-01

The new peripherally and non-peripherally tetra-1,3-bis[3-(diethylamino)phenoxy]propan-2-ol substituted zinc(II) phthalocyanine complexes (2a and 3a) and their quaternized amphiphilic derivatives (2b and 3b) have been synthesized and characterized using UV–vis, FT-IR, 1 H-NMR, 13 C-NMR, MS spectroscopic data and elemental analysis for the first time. The quaternized complexes (2b and 3b) show excellent solubility in water and DMSO which makes them potential photosensitizers for use in photodynamic therapy (PDT) of cancer. The photochemical (singlet oxygen generation and photodegradation under light irradiation) properties of these novel phthalocyanines are investigated in dimethylsulfoxide (DMSO) for non-quaternized complexes and in DMSO, phosphate buffered solution (PBS) or PBS+triton X-100 (TX) solution for quaternized complexes. In this study, the effects of the aggregation of the molecules, quaternization, position of the substituents (peripherally or non-peripherally) and nature of the solvents (DMSO, PBS or PBS+triton X-100) on the photochemical parameters of the zinc (II) phthalocyanines are also reported. In addition, a spectroscopic investigation of the binding behavior of the quaternized zinc(II) phthalocyanine complexes to bovine serum albumin (BSA) is also presented in this work. - Highlights: • Synthesis of zinc phthalocyanines is performed. • Photophysical and photochemical properties of phthalocyanines are studied. • Photodynamic therapy studies are performed

Demographic processes of developmentally peripheral areas in Hungary

Directory of Open Access Journals (Sweden)

Pénzes János

2015-01-01

Full Text Available The current study investigates the demographic processes and challenges of the Hungarian developmentally peripheral settlements. Demographic challenges can be regarded as important consequences of the social and economic disadvantages in spatial terms. However, the interrelating negative demographic tendencies cause even more backward situation blocking or hindering the development. The objective of the current analysis is to discover the demographic characteristics of the peripheral settlements, to detect the spatial disparities and to point out the correlation between backwardness and the investigated demographic phenomena with the help of the census databases 1980-2011 and local datasets on Roma population. Using methods of multivariate statistical analysis, seven indicators were selected in order to achieve the goals of the paper. Backward areas are primarily characterized by population decrease with significant disparities, but there were growing communities among them as well. Some small villages in Northern and Southwestern Hungary will foreseeably face complete depopulation within few years. Primarily small sized villages faced intense decrease in rate of natural change, but dynamic population growth was also detected. Migration loss tends to correlate with the extent of peripherality, as increasing values of migration balance accompany decreasing ratio of peripheral settlements in the area. The ratio of elderly population shows an expressively two-faced character, with the extremely aging and very juvenile settlements. The ratios of Roma population reflect the scale of peripherality. Extended ethnic change could be predicted in Northeastern and Southwestern Hungary and near the Middle Tisza valley. Presented demographic processes will make the backwardness of most of the peripheral settlements stable.

Optical coherent tomography in diagnoses of peripheral retinal degenarations

OpenAIRE

O. G. Pozdeyeva; T. B. Shaimov; A. Yu. Galin; R. B. Shaimov; T. A. Shaimova; A. V. Zolotova; A. V. Fomin

2014-01-01

Purpose: Studying the capabilities of optical coherence tomography (RTVue-100, OPTOVUE, USA) in evaluation of peripheral retinal degenerations, vitreoretinal adhesions, adjacent vitreous body as well as measurement of morphometric data.Methods: The study included 189 patients (239 eyes) with peripheral retinal degeneration. 77 men and 112 women aged 18 to 84 underwent an ophthalmologic examination since November 2012 until October 2013. The peripheral retina was visualized with the help of op...

Clinical impact of exercise in patients with peripheral arterial disease.

Science.gov (United States)

Novakovic, Marko; Jug, Borut; Lenasi, Helena

2017-08-01

Increasing prevalence, high morbidity and mortality, and decreased health-related quality of life are hallmarks of peripheral arterial disease. About one-third of peripheral arterial disease patients have intermittent claudication with deleterious effects on everyday activities, such as walking. Exercise training improves peripheral arterial disease symptoms and is recommended as first line therapy for peripheral arterial disease. This review examines the effects of exercise training beyond improvements in walking distance, namely on vascular function, parameters of inflammation, activated hemostasis and oxidative stress, and quality of life. Exercise training not only increases walking distance and physiologic parameters in patients with peripheral arterial disease, but also improves the cardiovascular risk profile by helping patients achieve better control of hypertension, hyperglycemia, obesity and dyslipidemia, thus further reducing cardiovascular risk and the prevalence of coexistent atherosclerotic diseases. American guidelines suggest supervised exercise training, performed for a minimum of 30-45 min, at least three times per week, for at least 12 weeks. Walking is the most studied exercise modality and its efficacy in improving cardiovascular parameters in patients with peripheral arterial disease has been extensively proven. As studies have shown that supervised exercise training improves walking performance, cardiovascular parameters and quality of life in patients with peripheral arterial disease, it should be encouraged and more often prescribed.

Modulation of individual steps in group I intron catalysis by a peripheral metal ion.

Science.gov (United States)

Forconi, Marcello; Piccirilli, Joseph A; Herschlag, Daniel

2007-10-01

Enzymes are complex macromolecules that catalyze chemical reactions at their active sites. Important information about catalytic interactions is commonly gathered by perturbation or mutation of active site residues that directly contact substrates. However, active sites are engaged in intricate networks of interactions within the overall structure of the macromolecule, and there is a growing body of evidence about the importance of peripheral interactions in the precise structural organization of the active site. Here, we use functional studies, in conjunction with published structural information, to determine the effect of perturbation of a peripheral metal ion binding site on catalysis in a well-characterized catalytic RNA, the Tetrahymena thermophila group I ribozyme. We perturbed the metal ion binding site by site-specifically introducing a phosphorothioate substitution in the ribozyme's backbone, replacing the native ligands (the pro-R (P) oxygen atoms at positions 307 and 308) with sulfur atoms. Our data reveal that these perturbations affect several reaction steps, including the chemical step, despite the absence of direct contacts of this metal ion with the atoms involved in the chemical transformation. As structural probing with hydroxyl radicals did not reveal significant change in the three-dimensional structure upon phosphorothioate substitution, the effects are likely transmitted through local, rather subtle conformational rearrangements. Addition of Cd(2+), a thiophilic metal ion, rescues some reaction steps but has deleterious effects on other steps. These results suggest that native interactions in the active site may have been aligned by the naturally occurring peripheral residues and interactions to optimize the overall catalytic cycle.

Nuclear power plant design characteristics. Structure of nuclear power plant design characteristics in the IAEA Power Reactor Information System (PRIS)

International Nuclear Information System (INIS)

2007-03-01

One of the IAEA's priorities has been to maintain the Power Reactor Information System (PRIS) database as a viable and useful source of information on nuclear reactors worldwide. To satisfy the needs of PRIS users as much as possible, the PRIS database has included also a set of nuclear power plant (NPP) design characteristics. Accordingly, the PRIS Technical Meeting, organized in Vienna 4-7 October 2004, initiated a thorough revision of the design data area of the PRIS database to establish the actual status of the data and make improvements. The revision first concentrated on a detailed review of the design data completion and the composition of the design characteristics. Based on the results of the review, a modified set and structure of the unit design characteristics for the PRIS database has been developed. The main objective of the development has been to cover all significant plant systems adequately and provide an even more comprehensive overview of NPP unit designs stored in the PRIS database

May Stakeholders be Involved in Design Without Informed Consent? The Case of Hidden Design.