WorldWideScience

Sample records for perform critical functions

  1. Extending Critical Performativity

    DEFF Research Database (Denmark)

    Spicer, André; Alvesson, Mats; Kärreman, Dan

    2016-01-01

    In this article we extend the debate about critical performativity. We begin by outlining the basic tenets of critical performativity and how this has been applied in the study of management and organization. We then address recent critiques of critical performance. We note these arguments suffer...... of public importance; engaging with non-academic groups using dialectical reasoning; scaling up insights through movement building; and propagating deliberation...

  2. Critical function monitoring system algorithm development

    International Nuclear Information System (INIS)

    Harmon, D.L.

    1984-01-01

    Accurate critical function status information is a key to operator decision-making during events threatening nuclear power plant safety. The Critical Function Monitoring System provides continuous critical function status monitoring by use of algorithms which mathematically represent the processes by which an operating staff would determine critical function status. This paper discusses in detail the systematic design methodology employed to develop adequate Critical Function Monitoring System algorithms

  3. Space Shuttle critical function audit

    Science.gov (United States)

    Sacks, Ivan J.; Dipol, John; Su, Paul

    1990-01-01

    A large fault-tolerance model of the main propulsion system of the US space shuttle has been developed. This model is being used to identify single components and pairs of components that will cause loss of shuttle critical functions. In addition, this model is the basis for risk quantification of the shuttle. The process used to develop and analyze the model is digraph matrix analysis (DMA). The DMA modeling and analysis process is accessed via a graphics-based computer user interface. This interface provides coupled display of the integrated system schematics, the digraph models, the component database, and the results of the fault tolerance and risk analyses.

  4. Dictionary criticism and lexicographical function theory

    DEFF Research Database (Denmark)

    Tarp, Sven

    2017-01-01

    This contribution discusses dictionary criticism in the light of the function theory. It starts analyzing the objective of dictionary criticism and lists eight of the most important purposes with which criticism has been made by supporters of the function theory. It then discusses the two main...... types of dictionary criticism, namely criticism of other authors’ dictionaries and self-criticism of one’s own dictionaries. Based on this discussion, it proceeds to a definition of the concept of dictionary criticism which is above all considered a theory-based activity, the outcome of which may...... by the supporters of the function theory, and the way it could be presented in order to create debate. Finally, the contribution indicates the important role dictionary criticism has had in the development of the function theory and endorses an open and critical discussion culture within lexicography....

  5. Critical Thinking and EFL Learners' Performance on Different Writing Modes

    Science.gov (United States)

    Golpour, Farhad

    2014-01-01

    The essential function of critical thinking in education is obvious by many studies done in this field. The main purpose of this article is to find the relationship between critical thinking levels of Iranian EFL learners and their performance on different modes of writing. The sample of the study selected among those who studying English at the…

  6. Holographic correlation functions in Critical Gravity

    Science.gov (United States)

    Anastasiou, Giorgos; Olea, Rodrigo

    2017-11-01

    We compute the holographic stress tensor and the logarithmic energy-momentum tensor of Einstein-Weyl gravity at the critical point. This computation is carried out performing a holographic expansion in a bulk action supplemented by the Gauss-Bonnet term with a fixed coupling. The renormalization scheme defined by the addition of this topological term has the remarkable feature that all Einstein modes are identically cancelled both from the action and its variation. Thus, what remains comes from a nonvanishing Bach tensor, which accounts for non-Einstein modes associated to logarithmic terms which appear in the expansion of the metric. In particular, we compute the holographic 1-point functions for a generic boundary geometric source.

  7. A critical review of the use and performance of different function types for modeling temperature-dependent development of arthropod larvae.

    Science.gov (United States)

    Quinn, Brady K

    2017-01-01

    Temperature-dependent development influences production rates of arthropods, including crustaceans important to fisheries and agricultural pests. Numerous candidate equation types (development functions) exist to describe the effect of temperature on development time, yet most studies use only a single type of equation and there is no consensus as to which, if any model predicts development rates better than the others, nor what the consequences of selecting a potentially incorrect model equation are on predicted development times. In this study, a literature search was performed of studies fitting development functions to development data of arthropod larvae (99 species). The published data of most (79) of these species were then fit with 33 commonly-used development functions. Overall performance of each function type and consequences of using a function other than the best one to model data were assessed. Performance was also related to taxonomy and the range of temperatures examined. The majority (91.1%) of studies were found to not use the best function out of those tested. Using the incorrect model lead to significantly less accurate (e.g., mean difference±SE 85.9±27.4%, range: -1.7 to 1725.5%) predictions of development times than the best function. Overall, more complex functions performed poorly relative to simpler ones. However, performance of some complex functions improved when wide temperature ranges were tested, which tended to be confined to studies of insects or arachnids compared with those of crustaceans. Results indicate the biological significance of choosing the best-fitting model to describe temperature-dependent development time data. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. 2011 Annual Criticality Safety Program Performance Summary

    Energy Technology Data Exchange (ETDEWEB)

    Andrea Hoffman

    2011-12-01

    The 2011 review of the INL Criticality Safety Program has determined that the program is robust and effective. The review was prepared for, and fulfills Contract Data Requirements List (CDRL) item H.20, 'Annual Criticality Safety Program performance summary that includes the status of assessments, issues, corrective actions, infractions, requirements management, training, and programmatic support.' This performance summary addresses the status of these important elements of the INL Criticality Safety Program. Assessments - Assessments in 2011 were planned and scheduled. The scheduled assessments included a Criticality Safety Program Effectiveness Review, Criticality Control Area Inspections, a Protection of Controlled Unclassified Information Inspection, an Assessment of Criticality Safety SQA, and this management assessment of the Criticality Safety Program. All of the assessments were completed with the exception of the 'Effectiveness Review' for SSPSF, which was delayed due to emerging work. Although minor issues were identified in the assessments, no issues or combination of issues indicated that the INL Criticality Safety Program was ineffective. The identification of issues demonstrates the importance of an assessment program to the overall health and effectiveness of the INL Criticality Safety Program. Issues and Corrective Actions - There are relatively few criticality safety related issues in the Laboratory ICAMS system. Most were identified by Criticality Safety Program assessments. No issues indicate ineffectiveness in the INL Criticality Safety Program. All of the issues are being worked and there are no imminent criticality concerns. Infractions - There was one criticality safety related violation in 2011. On January 18, 2011, it was discovered that a fuel plate bundle in the Nuclear Materials Inspection and Storage (NMIS) facility exceeded the fissionable mass limit, resulting in a technical safety requirement (TSR) violation. The

  9. Critical Care Organizations: Business of Critical Care and Value/Performance Building.

    Science.gov (United States)

    Leung, Sharon; Gregg, Sara R; Coopersmith, Craig M; Layon, A Joseph; Oropello, John; Brown, Daniel R; Pastores, Stephen M; Kvetan, Vladimir

    2018-01-01

    New, value-based regulations and reimbursement structures are creating historic care management challenges, thinning the margins and threatening the viability of hospitals and health systems. The Society of Critical Care Medicine convened a taskforce of Academic Leaders in Critical Care Medicine on February 22, 2016, during the 45th Critical Care Congress to develop a toolkit drawing on the experience of successful leaders of critical care organizations in North America for advancing critical care organizations (Appendix 1). The goal of this article was to provide a roadmap and call attention to key factors that adult critical care medicine leadership in both academic and nonacademic setting should consider when planning for value-based care. Relevant medical literature was accessed through a literature search. Material published by federal health agencies and other specialty organizations was also reviewed. Collaboratively and iteratively, taskforce members corresponded by electronic mail and held monthly conference calls to finalize this report. The business and value/performance critical care organization building section comprised of leaders of critical care organizations with expertise in critical care administration, healthcare management, and clinical practice. Two phases of critical care organizations care integration are described: "horizontal," within the system and regionalization of care as an initial phase, and "vertical," with a post-ICU and postacute care continuum as a succeeding phase. The tools required for the clinical and financial transformation are provided, including the essential prerequisites of forming a critical care organization; the manner in which a critical care organization can help manage transformational domains is considered. Lastly, how to achieve organizational health system support for critical care organization implementation is discussed. A critical care organization that incorporates functional clinical horizontal and

  10. Performance management in healthcare: a critical analysis.

    Science.gov (United States)

    Hewko, Sarah J; Cummings, Greta G

    2016-01-01

    Purpose - The purpose of this paper is to explore the underlying theoretical assumptions and implications of current micro-level performance management and evaluation (PME) practices, specifically within health-care organizations. PME encompasses all activities that are designed and conducted to align employee outputs with organizational goals. Design/methodology/approach - PME, in the context of healthcare, is analyzed through the lens of critical theory. Specifically, Habermas' theory of communicative action is used to highlight some of the questions that arise in looking critically at PME. To provide a richer definition of key theoretical concepts, the authors conducted a preliminary, exploratory hermeneutic semantic analysis of the key words "performance" and "management" and of the term "performance management". Findings - Analysis reveals that existing micro-level PME systems in health-care organizations have the potential to create a workforce that is compliant, dependent, technically oriented and passive, and to support health-care systems in which inequalities and power imbalances are perpetually reinforced. Practical implications - At a time when the health-care system is under increasing pressure to provide high-quality, affordable services with fewer resources, it may be wise to investigate new sector-specific ways of evaluating and managing performance. Originality/value - In this paper, written for health-care leaders and health human resource specialists, the theoretical assumptions and implications of current PME practices within health-care organizations are explored. It is hoped that readers will be inspired to support innovative PME practices within their organizations that encourage peak performance among health-care professionals.

  11. System Predicts Critical Runway Performance Parameters

    Science.gov (United States)

    Millen, Ernest W.; Person, Lee H., Jr.

    1990-01-01

    Runway-navigation-monitor (RNM) and critical-distances-process electronic equipment designed to provide pilot with timely and reliable predictive navigation information relating to takeoff, landing and runway-turnoff operations. Enables pilot to make critical decisions about runway maneuvers with high confidence during emergencies. Utilizes ground-referenced position data only to drive purely navigational monitor system independent of statuses of systems in aircraft.

  12. Media Literacy Function in Critical Blogs

    Science.gov (United States)

    Fedorov, Alexander; Levitskaya, Anastasia

    2015-01-01

    The Internet is widely recognized as playing an important role in facilitating education on a range of issues, including media literacy. Analyzing the media critical activity of contemporary Russian bloggers, the authors of the article reveal the following reasons for popularity or, on the contrary, unpopularity of blogger's media criticism:…

  13. Unbounded critical points for a class of lower semicontinuous functionals

    OpenAIRE

    Pellacci, Benedetta; Squassina, Marco

    2003-01-01

    In this paper we prove existence and multiplicity results of unbounded critical points for a general class of weakly lower semicontinuous functionals. We will apply a suitable nonsmooth critical point theory.

  14. Critical review of safety performance metrics

    NARCIS (Netherlands)

    Karanikas, Nektarios

    2016-01-01

    Various tools for safety performance measurement have been introduced in order to fulfil the need for safety monitoring in organisations, which is tightly related to their overall performance and achievement of their business goals. Such tools include accident rates, benchmarking, safety culture and

  15. Performance and Job Satisfaction - A Critical Review

    Directory of Open Access Journals (Sweden)

    Devaki Devi Puvada

    2012-04-01

    Full Text Available The human aspect in the present context has acquired immense importance. The needbased motivational theories relate need and psychological gratification to motivation and jobsatisfaction; they consider performance as the endresult. However, Lawler and Porter postulatereversely that job performance leads to job satisfaction. The study focuses on testing the degree anddirection of the relationship between Performance and Job Satisfaction with intervening variablessuch as job relations, commitment, role conflict, value system, motivation and organizational climateand with socio-economic variables. The study is conducted on 928 employees drawn from 13 publicsector and 5 private sector organizations using simple random sampling and males as the matchingsample in the State of Andhra Pradesh, India. It isevident from the study that the performance levelof the employees is significantly lesser than theirjob satisfaction level. The analysis leads to state thatall those performing well are satisfied and all those satisfied do not perform well indicating thatperformance leads to job satisfaction, job satisfaction does not lead necessarily to performance andthe relationship is intertwined. This empirical evidence supports the theory of Lawler and Porter andsets direction for future studies at micro level.

  16. The critical safety functions and plant operation

    International Nuclear Information System (INIS)

    Corcoran, W.R.; Church, J.F.; Cross, M.T.; Guinn, W.M.; Porter, N.J.

    1981-01-01

    The operator's role in nuclear safety is outlined and the concept of ''safety functions'' introduced. Safety functions are a group of actions that prevent core melt or minimize radiation releases to the general public. They can be used to provide a hierarchy of practical plant protection that an operator should use. The plant safety evaluation uses four inputs in predicting the results of an event: the event initiator, the plant design, the initial plant conditions and setup, and the operator actions. If any of these inputs are not as assumed in the evaluation, confidence that the consequences will be as predicted is reduced. Based on the safety evaluation, the operator has three roles in assuring that the consequences of an event will be no worse than the predicted acceptable results: Maintain plant setup in readiness to properly respond. Operate the plant in a manner such that fewer, milder events minimize the frequency and the severity of adverse events. Monitor the plant to verify that the safety functions are accomplished. The operator needs a systematic approach to mitigating the consequences of an event. The concept of safety functions introduces this systematic approach and presents a hierarchy of protection. If the operator has difficulty identifying an event for any reason, the systematic safety function approach allows accomplishing the overall path of mitigating consequences. Ten functions designed to protect against core melt, preserve containment integrity, prevent indirect release of radioactivity, and maintain vital auxiliaries needed to support the other safety functions are identified

  17. The critical safety functions and plant operation

    International Nuclear Information System (INIS)

    Corcoran, W.R.; Church, J.F.; Porter, N.J.; Cross, M.T.; Guinn, W.M.

    1981-01-01

    The paper outlines the operator's role in nuclear safety and introduces the concept of ''safety functions''. Safety functions are a group of actions that prevent core melt or minimize radiation releases to the general public. They can be used to provide a hierarchy of practical plant protection that an operator should use. ''An accident identical to that at Three Mile Island is not going to happen again'', said the Rogovin investigators. The concepts put forward in this paper are intended to help the operator avoid serious consequence from the next unexpected threat. On the basis of the safety evaluation, the operator has three roles in assuring that the consequences of an event will be no worse than the predicted acceptable results. These three operator roles are: first, maintain plant setup in readiness to properly respond; second, operate the plant in a manner such that fewer, milder events minimize the frequency and the severity of adverse events; third, the operator needs to monitor the plant to verify that the safety functions are accomplished. The operator needs a systematic approach to mitigating the consequences of an event. The concept of ''safety function'' introduces that systematic approach and prevents a hierarchy of protection. If the operator has difficulty in identifying an event for any reason, the systematic safety function approach allows ones to accomplish the overall path of mitigating consequences. There are ten identified functions designed to protect against core melt, preserve containment integrity, prevent indirect release of radioactivity, and maintain vital auxiliaries needed to support the other safety functions. The paper describes in detail the operator's role and the safety functions, and provides many examples of the use of alternative success paths to accomplish the safety function

  18. Deconstructing Global Markets through Critical Performative Experiences in Puerto Rico

    Science.gov (United States)

    Medina, Carmen Liliana; Weltsek, Gustave J.

    2013-01-01

    Critical Performative Pedagogies, the idea that "The nature of drama as a once removed creative experience turns non-critical implicit classroom identity formation into explicit identity performance as it asks participants to actively reflect upon how identity is created and engaged within fictional social interactions." (Weltsek and…

  19. Critical review of glass performance modeling

    International Nuclear Information System (INIS)

    Bourcier, W.L.

    1994-07-01

    Borosilicate glass is to be used for permanent disposal of high-level nuclear waste in a geologic repository. Mechanistic chemical models are used to predict the rate at which radionuclides will be released from the glass under repository conditions. The most successful and useful of these models link reaction path geochemical modeling programs with a glass dissolution rate law that is consistent with transition state theory. These models have been used to simulate several types of short-term laboratory tests of glass dissolution and to predict the long-term performance of the glass in a repository. Although mechanistically based, the current models are limited by a lack of unambiguous experimental support for some of their assumptions. The most severe problem of this type is the lack of an existing validated mechanism that controls long-term glass dissolution rates. Current models can be improved by performing carefully designed experiments and using the experimental results to validate the rate-controlling mechanisms implicit in the models. These models should be supported with long-term experiments to be used for model validation. The mechanistic basis of the models should be explored by using modern molecular simulations such as molecular orbital and molecular dynamics to investigate both the glass structure and its dissolution process

  20. Critical review of glass performance modeling

    Energy Technology Data Exchange (ETDEWEB)

    Bourcier, W.L. [Lawrence Livermore National Lab., CA (United States)

    1994-07-01

    Borosilicate glass is to be used for permanent disposal of high-level nuclear waste in a geologic repository. Mechanistic chemical models are used to predict the rate at which radionuclides will be released from the glass under repository conditions. The most successful and useful of these models link reaction path geochemical modeling programs with a glass dissolution rate law that is consistent with transition state theory. These models have been used to simulate several types of short-term laboratory tests of glass dissolution and to predict the long-term performance of the glass in a repository. Although mechanistically based, the current models are limited by a lack of unambiguous experimental support for some of their assumptions. The most severe problem of this type is the lack of an existing validated mechanism that controls long-term glass dissolution rates. Current models can be improved by performing carefully designed experiments and using the experimental results to validate the rate-controlling mechanisms implicit in the models. These models should be supported with long-term experiments to be used for model validation. The mechanistic basis of the models should be explored by using modern molecular simulations such as molecular orbital and molecular dynamics to investigate both the glass structure and its dissolution process.

  1. Conditions for Critical Performativity in a Polycontextural Society

    DEFF Research Database (Denmark)

    Knudsen, Morten

    2017-01-01

    of sentences to a societal level, and taking inspiration from the failure of Marxist notions of the relation between theory and practice, the paper suggests thinking critical performativity under the conditions of differentiation. This idea is qualified by means of Niklas Luhmann and his theory...... elements of a critical research strategy – under polycontextural conditions - and four guidelines for a critical science are suggested....

  2. Ultrasonographic Assessment of Diaphragm Function in Critically Ill Subjects.

    Science.gov (United States)

    Umbrello, Michele; Formenti, Paolo

    2016-04-01

    The majority of patients admitted to the ICU require mechanical ventilation as a part of their process of care. However, mechanical ventilation itself or the underlying disease can lead to dysfunction of the diaphragm, a condition that may contribute to the failure of weaning from mechanical ventilation. However, extended time on the ventilator increases health-care costs and greatly increases patient morbidity and mortality. Nevertheless, symptoms and signs of muscle disease in a bedridden (or bed rest-only) ICU patient are often difficult to assess because of concomitant confounding factors. Conventional assessment of diaphragm function lacks specific, noninvasive, time-saving, and easily performed bedside tools or requires patient cooperation. Recently, the use of ultrasound has raised great interest as a simple, noninvasive method of quantification of diaphragm contractile activity. In this review, we discuss the physiology and the relevant pathophysiology of diaphragm function, and we summarize the recent findings concerning the evaluation of its (dys)function in critically ill patients, with a special focus on the role of ultrasounds. We describe how to assess diaphragm excursion and diaphragm thickening during breathing and the meaning of these measurements under spontaneous or mechanical ventilation as well as the reference values in health and disease. The spread of ultrasonographic assessment of diaphragm function may possibly result in timely identification of patients with diaphragm dysfunction and to a potential improvement in the assessment of recovery from diaphragm weakness. Copyright © 2016 by Daedalus Enterprises.

  3. Critical Arts-Based Research in Education: Performing Undocumented Historias

    Science.gov (United States)

    Bagley, Carl; Castro-Salazar, Ricardo

    2012-01-01

    The article seeks to elucidate and academically position the genre of critical arts-based research in education. The article fuses Critical Race Theory (CRT), life history and performance, alongside work with undocumented American students of Mexican origin, to show how a politicised qualitative paradigmatic re envisioning can occur in which…

  4. Performance management when innovation and learning become critical performance indicators

    NARCIS (Netherlands)

    Molleman, E.; Timmerman, H.

    2003-01-01

    If the organization's leading performance indicators shift towards innovation and the creation of knowledge, this will result in more non-routine work and a higher level of interdependency among workers. We argue that a contingent performance management (PM) system has to focus on Learning and group

  5. Off-critical local height probabilities on a plane and critical partition functions on a cylinder

    Directory of Open Access Journals (Sweden)

    Omar Foda

    2018-03-01

    Full Text Available We compute off-critical local height probabilities in regime-III restricted solid-on-solid models in a 4N-quadrant spiral geometry, with periodic boundary conditions in the angular direction, and fixed boundary conditions in the radial direction, as a function of N, the winding number of the spiral, and τ, the departure from criticality of the model, and observe that the result depends only on the product Nτ. In the limit N→1, τ→τ0, such that τ0 is finite, we recover the off-critical local height probability on a plane, τ0-away from criticality. In the limit N→∞, τ→0, such that Nτ=τ0 is finite, and following a conformal transformation, we obtain a critical partition function on a cylinder of aspect-ratio τ0. We conclude that the off-critical local height probability on a plane, τ0-away from criticality, is equal to a critical partition function on a cylinder of aspect-ratio τ0, in agreement with a result of Saleur and Bauer.

  6. Experience with performance based training of nuclear criticality safety engineers

    International Nuclear Information System (INIS)

    Taylor, R.G.

    1993-01-01

    For non-reactor nuclear facilities, the U.S. Department of Energy (DOE) does not require that nuclear criticality safety engineers demonstrate qualification for their job. It is likely, however, that more formalism will be required in the future. Current DOE requirements for those positions which do have to demonstrate qualification indicate that qualification should be achieved by using a systematic approach such as performance based training (PBT). Assuming that PBT would be an acceptable mechanism for nuclear criticality safety engineer training in a more formal environment, a site-specific analysis of the nuclear criticality safety engineer job was performed. Based on this analysis, classes are being developed and delivered to a target audience of newer nuclear criticality safety engineers. Because current interest is in developing training for selected aspects of the nuclear criticality safety engineer job, the analysis is incompletely developed in some areas

  7. Maximizing Team Performance: The Critical Role of the Nurse Leader.

    Science.gov (United States)

    Manges, Kirstin; Scott-Cawiezell, Jill; Ward, Marcia M

    2017-01-01

    Facilitating team development is challenging, yet critical for ongoing improvement across healthcare settings. The purpose of this exemplary case study is to examine the role of nurse leaders in facilitating the development of a high-performing Change Team in implementing a patient safety initiative (TeamSTEPPs) using the Tuckman Model of Group Development as a guiding framework. The case study is the synthesis of 2.5 years of critical access hospital key informant interviews (n = 50). Critical juncture points related to team development and key nurse leader actions are analyzed, suggesting that nurse leaders are essential to maximize clinical teams' performance. © 2016 Wiley Periodicals, Inc.

  8. Mammalian enabled (Mena) is a critical regulator of cardiac function.

    Science.gov (United States)

    Aguilar, Frédérick; Belmonte, Stephen L; Ram, Rashmi; Noujaim, Sami F; Dunaevsky, Olga; Protack, Tricia L; Jalife, Jose; Todd Massey, H; Gertler, Frank B; Blaxall, Burns C

    2011-05-01

    Mammalian enabled (Mena) of the Drosophila enabled/vasodilator-stimulated phosphoprotein gene family is a cytoskeletal protein implicated in actin regulation and cell motility. Cardiac Mena expression is enriched in intercalated discs (ICD), the critical intercellular communication nexus between adjacent muscle cells. We previously identified Mena gene expression to be a key predictor of human and murine heart failure (HF). To determine the in vivo function of Mena in the heart, we assessed Mena protein expression in multiple HF models and characterized the effects of genetic Mena deletion on cardiac structure and function. Immunoblot analysis revealed significant upregulation of Mena protein expression in left ventricle tissue from patients with end-stage HF, calsequestrin-overexpressing mice, and isoproterenol-infused mice. Characterization of the baseline cardiac function of adult Mena knockout mice (Mena(-/-)) via echocardiography demonstrated persistent cardiac dysfunction, including a significant reduction in percent fractional shortening compared with wild-type littermates. Electrocardiogram PR and QRS intervals were significantly prolonged in Mena(-/-) mice, manifested by slowed conduction on optical mapping studies. Ultrastructural analysis of Mena(-/-) hearts revealed disrupted organization and widening of ICD structures, mislocalization of the gap junction protein connexin 43 (Cx43) to the lateral borders of cardiomyoycytes, and increased Cx43 expression. Furthermore, the expression of vinculin (an adherens junction protein) was significantly reduced in Mena(-/-) mice. We report for the first time that genetic ablation of Mena results in cardiac dysfunction, highlighted by diminished contractile performance, disrupted ICD structure, and slowed electrical conduction.

  9. Functional High Performance Financial IT

    DEFF Research Database (Denmark)

    Berthold, Jost; Filinski, Andrzej; Henglein, Fritz

    2011-01-01

    at the University of Copenhagen that attacks this triple challenge of increased performance, transparency and productivity in the financial sector by a novel integration of financial mathematics, domain-specific language technology, parallel functional programming, and emerging massively parallel hardware. HIPERFIT......The world of finance faces the computational performance challenge of massively expanding data volumes, extreme response time requirements, and compute-intensive complex (risk) analyses. Simultaneously, new international regulatory rules require considerably more transparency and external...... auditability of financial institutions, including their software systems. To top it off, increased product variety and customisation necessitates shorter software development cycles and higher development productivity. In this paper, we report about HIPERFIT, a recently etablished strategic research center...

  10. Critical safety function guidelines for experimental fusion facilities

    International Nuclear Information System (INIS)

    Cadwallader, L.C.

    1989-01-01

    As fusion experiments proceed toward deuterium-tritium operation, more attention is being given to public safety. This paper presents the four classes of functions that fusion experiments must provide to assure safe, stable shutdown and retention of radionuclides. These functions are referred to as critical safety functions (CSFs). Selecting CSFs is an important step in probabilistic risk assessment (PRA). An example of CSF selection and usage for the Compact Ignition Tokamak (CIT) is also presented. 10 refs., 6 figs

  11. Critical safety function guidelines for experimental fusion facilities

    International Nuclear Information System (INIS)

    Cadwallader, L.C.

    1989-01-01

    As fusion experiments proceed toward deuterium-tritium operation, more attention is being given to public safety. This paper presents the four classes of functions that fusion experiments must provide to assure safe, stable shutdown and retention of radionuclides. These functions are referred to as critical safety functions (CSFs). Selecting CSFs is an important step in probabilistic risk assessment (PRA). An example of CSF selection and usage for the Compact Ignition Tokamak (CIT) is also presented

  12. Evaluating Models of Human Performance: Safety-Critical Systems Applications

    Science.gov (United States)

    Feary, Michael S.

    2012-01-01

    This presentation is part of panel discussion on Evaluating Models of Human Performance. The purpose of this panel is to discuss the increasing use of models in the world today and specifically focus on how to describe and evaluate models of human performance. My presentation will focus on discussions of generating distributions of performance, and the evaluation of different strategies for humans performing tasks with mixed initiative (Human-Automation) systems. I will also discuss issues with how to provide Human Performance modeling data to support decisions on acceptability and tradeoffs in the design of safety critical systems. I will conclude with challenges for the future.

  13. Experience with performance based training of nuclear criticality safety engineers

    International Nuclear Information System (INIS)

    Taylor, R.G.

    1993-01-01

    Historically, new entrants to the practice of nuclear criticality safety have learned their job primarily by on-the-job training (OJT) often by association with an experienced nuclear criticality safety engineer who probably also learned their job by OJT. Typically, the new entrant learned what he/she needed to know to solve a particular problem and accumulated experience as more problems were solved. It is likely that more formalism will be required in the future. Current US Department of Energy requirements for those positions which have to demonstrate qualification indicate that it should be achieved by using a systematic approach such as performance based training (PBT). Assuming that PBT would be an acceptable mechanism for nuclear criticality safety engineer training in a more formal environment, a site-specific analysis of the nuclear criticality safety engineer job was performed. Based on this analysis, classes are being developed and delivered to a target audience of newer nuclear criticality safety engineers. Because current interest is in developing training for selected aspects of the nuclear criticality safety engineer job, the analysis i's incompletely developed in some areas. Details of this analysis are provided in this report

  14. The Expansion of Criminal Control: A Critical to Feather Functions

    Directory of Open Access Journals (Sweden)

    Mariel Muraro

    2015-12-01

    Full Text Available This article aims to relate the theories of punishment, retributive and preventive, with the criminological discourse, and make brief notes about the negative theories and criticism of the sentence. The article begins by making a few notes on the mass incarceration of the phenomenon, then going to discuss and present the form of action of the police state. Then they present the theories of punishment under the critical perspective, and then work the two main critical theories of punishment, thus treating the position Prof. Eugenio Raúl Zaffaroni and Prof. Juarez Cirino dos Santos. These presentations and discussions have left the critical discourse, not taking our work as end revisit the theoretical construction of the functions of the pen, just to demonstrate how the discourse of shame built by criminal law legitimizes selective and violent actions of the penal system.

  15. Changes in functional status after treatment of critical limb ischemia

    NARCIS (Netherlands)

    Frans, Franceline Alkine; Met, Rosemarie; Koelemay, Mark J. W.; Bipat, Shandra; Dijkgraaf, Marcel G. W.; Legemate, Dink A.; Reekers, Jim A.

    2013-01-01

    This study evaluated changes in functional status with the Academic Medical Center Linear Disability Score (ALDS) and in quality of life with the Vascular Quality of Life Questionnaire (VascuQol) in patients treated for critical limb ischemia (CLI). We conducted a prospective observational cohort

  16. Critical Performance of Turbopump Mechanical Elements for Rocket Engine

    Science.gov (United States)

    Takada, Satoshi; Kikuchi, Masataka; Sudou, Takayuki; Iwasaki, Fumiya; Watanabe, Yoshiaki; Yoshida, Makoto

    It is generally acknowledged that bearings and axial seals have a tendency to go wrong compared with other rocket engine elements. And when those components have malfunction, missions scarcely succeed. However, fundamental performance (maximum rotational speed, minimum flow rate, power loss, durability, etc.) of those components has not been grasped yet. Purpose of this study is to grasp a critical performance of mechanical seal and hybrid ball bearing of turbopump. In this result, it was found that bearing outer race temperature and bearing coolant outlet temperature changed along saturation line of liquid hydrogen when flow rate was decreased under critical pressure. And normal operation of bearing was possible under conditions of more than 70,000 rpm of rotational speed and more than 0.2 liter/s of coolant flow rate. Though friction coefficient of seal surface increased several times of original value after testing, the seal showed a good performance same as before.

  17. Rethinking platelet function: thrombocytopenia induced immunodeficiency in critical illness

    DEFF Research Database (Denmark)

    Ostrowski, Sisse R; Johansson, Per Ingemar

    2011-01-01

    Thrombocytopenia in critical illness predicts a poor clinical outcome. Apart from its role in microvascular thrombus formation, it is widely anticipated that this association is indirect rather than causal. Emerging evidence however indicates that platelets are also immune competent cells. Like...... per se results in immunodeficiency through loss of platelet-mediated immune functions, and propose that thrombocytopenia induced immunodeficiency in critical illness in part explain the negative predictive value of low or declining platelet count. We propose that rethinking the risks...... of thrombocytopenia to include not only bleeding but also immunodeficiency and immune dysregulation along with the conduct of studies investigating mechanisms contributing to thrombocytopenia induced poor non-hemorrhagic outcome in critical illness, may be means to improve outcome in these patients through...

  18. Vertex functions at finite momentum: Application to antiferromagnetic quantum criticality

    Science.gov (United States)

    Wölfle, Peter; Abrahams, Elihu

    2016-02-01

    We analyze the three-point vertex function that describes the coupling of fermionic particle-hole pairs in a metal to spin or charge fluctuations at nonzero momentum. We consider Ward identities, which connect two-particle vertex functions to the self-energy, in the framework of a Hubbard model. These are derived using conservation laws following from local symmetries. The generators considered are the spin density and particle density. It is shown that at certain antiferromagnetic critical points, where the quasiparticle effective mass is diverging, the vertex function describing the coupling of particle-hole pairs to the spin density Fourier component at the antiferromagnetic wave vector is also divergent. Then we give an explicit calculation of the irreducible vertex function for the case of three-dimensional antiferromagnetic fluctuations, and show that it is proportional to the diverging quasiparticle effective mass.

  19. Performance Testing Methodology for Safety-Critical Programmable Logic Controller

    International Nuclear Information System (INIS)

    Kim, Chang Ho; Oh, Do Young; Kim, Ji Hyeon; Kim, Sung Ho; Sohn, Se Do

    2009-01-01

    The Programmable Logic Controller (PLC) for use in Nuclear Power Plant safety-related applications is being developed and tested first time in Korea. This safety-related PLC is being developed with requirements of regulatory guideline and industry standards for safety system. To test that the quality of the developed PLC is sufficient to be used in safety critical system, document review and various product testings were performed over the development documents for S/W, H/W, and V/V. This paper provides the performance testing methodology and its effectiveness for PLC platform conducted by KOPEC

  20. Simulated front crawl swimming performance related to critical speed and critical power.

    Science.gov (United States)

    Toussaint, H M; Wakayoshi, K; Hollander, A P; Ogita, F

    1998-01-01

    Competitive pool swimming events range in distance from 50 to 1500 m. Given the difference in performance times (+/- 23-1000 s), the contribution of the aerobic and anaerobic energy systems changes considerably with race distance. In training practice the regression line between swimming distance and time (Distance = critical velocity x time + anaerobic swimming capacity) is used to determine the individual capacity of the aerobic and anaerobic metabolic pathways. Although there is confidence that critical velocity and anaerobic swimming capacity are fitness measures that separate aerobic and anaerobic components, a firm theoretical basis for the interpretation of these results does not exist. The purpose of this study was to evaluate the critical power concept and anaerobic swimming capacity as measures of the aerobic and anaerobic capacity using a modeling approach. A systems model was developed that relates the mechanics and energetics involved in front crawl swimming performance. From actual swimming flume measurements, the time dependent aerobic and anaerobic energy release was modeled. Data derived from the literature were used to relate the energy cost of front crawl swimming to swimming velocity. A balance should exist between the energy cost to swim a distance in a certain time and the concomitant aerobic and anaerobic energy release. The ensuing model was used to predict performance times over a range of distances (50-1500 m) and to calculate the regression line between swimming distance and time. Using a sensitivity analysis, it was demonstrated that the critical velocity is indicative for the capacity of the aerobic energy system. Estimates of the anaerobic swimming capacity, however, were influenced by variations in both anaerobic and aerobic energy release. Therefore, it was concluded that the anaerobic swimming capacity does not provide a reliable estimate of the anaerobic capacity.

  1. Protective design of critical infrastructure with high performance concretes

    International Nuclear Information System (INIS)

    Riedel, W.; Nöldgen, M.; Stolz, A.; Roller, C.

    2012-01-01

    Conclusions: High performance concrete constructions will allow innovative design solutions for critical infrastructures. Validation of engineering methods can reside on large and model scale experiments conducted on conventional concrete structures. New consistent impact experiments show extreme protection potential for UHPC. Modern FEM with concrete models and explicit rebar can model HPC and UHPC penetration resistance. SDOF and TDOF approaches are valuable design tools on local and global level. Combination of at least 2 out of 3 design methods FEM – XDOF- EXP allow reliable prediction and efficient innovative designs

  2. Effect of Functional diversity on Software Performance

    OpenAIRE

    Viswanatha Rao, Balajee

    2011-01-01

    For the past few decades, there has been numerous literature produced on functional diversity and performance. However, the relationship between functional diversity and performance in software industry is clearly not explained and results are found to be inconsistent. The main focus of this research is to explore the effects of functional diversity on software project performance by conducting a qualitative study. Four metrics were chosen from literature namely decision making, creativity an...

  3. Critical Factors Explaining the Leadership Performance of High-Performing Principals

    Science.gov (United States)

    Hutton, Disraeli M.

    2018-01-01

    The study explored critical factors that explain leadership performance of high-performing principals and examined the relationship between these factors based on the ratings of school constituents in the public school system. The principal component analysis with the use of Varimax Rotation revealed that four components explain 51.1% of the…

  4. Critical Zone Experimental Design to Assess Soil Processes and Function

    Science.gov (United States)

    Banwart, Steve

    2010-05-01

    Through unsustainable land use practices, mining, deforestation, urbanisation and degradation by industrial pollution, soil losses are now hypothesized to be much faster (100 times or more) than soil formation - with the consequence that soil has become a finite resource. The crucial challenge for the international research community is to understand the rates of processes that dictate soil mass stocks and their function within Earth's Critical Zone (CZ). The CZ is the environment where soils are formed, degrade and provide their essential ecosystem services. Key among these ecosystem services are food and fibre production, filtering, buffering and transformation of water, nutrients and contaminants, storage of carbon and maintaining biological habitat and genetic diversity. We have initiated a new research project to address the priority research areas identified in the European Union Soil Thematic Strategy and to contribute to the development of a global network of Critical Zone Observatories (CZO) committed to soil research. Our hypothesis is that the combined physical-chemical-biological structure of soil can be assessed from first-principles and the resulting soil functions can be quantified in process models that couple the formation and loss of soil stocks with descriptions of biodiversity and nutrient dynamics. The objectives of this research are to 1. Describe from 1st principles how soil structure influences processes and functions of soils, 2. Establish 4 European Critical Zone Observatories to link with established CZOs, 3. Develop a CZ Integrated Model of soil processes and function, 4. Create a GIS-based modelling framework to assess soil threats and mitigation at EU scale, 5. Quantify impacts of changing land use, climate and biodiversity on soil function and its value and 6. Form with international partners a global network of CZOs for soil research and deliver a programme of public outreach and research transfer on soil sustainability. The

  5. Physiological Factors Contributing to Postflight Changes in Functional Performance

    Science.gov (United States)

    Bloomberg, J. J.; Feedback, D. L.; Feiverson, A. H.; Lee, S. M. C.; Mulavara, A. P.; Peters, B. T.; Platts, S. H.; Reschke, M. F.; Ryder, J.; Spiering, B. A.; hide

    2009-01-01

    Astronauts experience alterations in multiple physiological systems due to exposure to the microgravity conditions of space flight. These physiological changes include sensorimotor disturbances, cardiovascular deconditioning and loss of muscle mass and strength. These changes might affect the ability of crewmembers to perform critical mission tasks immediately after landing on lunar and Martian surfaces. To date, changes in functional performance have not been systematically studied or correlated with physiological changes. To understand how changes in physiological function impact functional performance an interdisciplinary pre/postflight testing regimen (Functional Task Test, FTT) has been developed that systematically evaluates both astronaut postflight functional performance and related physiological changes. The overall objectives of the FTT are to: Develop a set of functional tasks that represent critical mission tasks for Constellation. Determine the ability to perform these tasks after flight. Identify the key physiological factors that contribute to functional decrements. Use this information to develop targeted countermeasures. The functional test battery was designed to address high priority tasks identified by the Constellation program as critical for mission success. The set of functional tests making up the FTT include the: 1) Seat Egress and Walk Test, 2) Ladder Climb Test, 3) Recovery from Fall/Stand Test, 4) Rock Translation Test, 5) Jump Down Test, 6) Torque Generation Test, and 7) Construction Activity Board Test. Corresponding physiological measures include assessments of postural and gait control, dynamic visual acuity, fine motor control, plasma volume, orthostatic intolerance, upper and lower body muscle strength, power, fatigue, control and neuromuscular drive. Crewmembers will perform both functional and physiological tests before and after short (Shuttle) and long-duration (ISS) space flight. Data will be collected on R+0 (Shuttle only), R

  6. Preliminary Design of Critical Function Monitoring System of PGSFR

    International Nuclear Information System (INIS)

    2015-01-01

    A PGSFR (Prototype Gen-IV Sodium-cooled Fast Reactor) is under development at Korea Atomic Energy Research Institute. A critical function monitoring system of the PGSFR is preliminarily studied. The functions of CFMS are to display critical plant variables related to the safety of the plant during normal and accident conditions and guide the operators corrective actions to keep the plant in a safe condition and mitigate the consequences of accidents. The minimal critical functions of the PGSFR are composed of reactivity control, reactor core cooling, reactor coolant system integrity, primary heat transfer system(PHTS) heat removal, sodium water reaction mitigation, radiation control and containment conditions. The variables and alarm legs of each critical function of the PGSFR are as follows; - Reactivity control: The variables of reactivity control function are power range neutron flux instrumentation, intermediate range neutron flux instrumentation, source range neutron flux instrumentation, and control rod bottom contacts. The alarm leg to display the reactivity controls consists of status of control drop malfunction, high post trip power and thermal reactivity addition. - Reactor core cooling: The variables are PHTS sodium level, hot pool temperature of PHTS, subassembly exit temperature, cold pool temperature of the PHTS, PHTS pump current, and PHTS pump breaker status. The alarm leg consists of high core delta temperature, low sodium level of the PHTS, high subassembly exit temperature, and low PHTS pump load. - Reactor coolant system integrity: The variables are PHTS sodium level, cover gas pressure, and safeguard vessel sodium level. The alarm leg is composed of low sodium level of PHTS, high cover gas pressure and high sodium level of the safety guard vessel. - PHTS heat removal: The variables are PHTS sodium level, hot pool temperature of PHTS, core exit temperature, cold pool temperature of the PHTS, flow rate of passive residual heat removal system

  7. Preliminary Design of Critical Function Monitoring System of PGSFR

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-07-01

    A PGSFR (Prototype Gen-IV Sodium-cooled Fast Reactor) is under development at Korea Atomic Energy Research Institute. A critical function monitoring system of the PGSFR is preliminarily studied. The functions of CFMS are to display critical plant variables related to the safety of the plant during normal and accident conditions and guide the operators corrective actions to keep the plant in a safe condition and mitigate the consequences of accidents. The minimal critical functions of the PGSFR are composed of reactivity control, reactor core cooling, reactor coolant system integrity, primary heat transfer system(PHTS) heat removal, sodium water reaction mitigation, radiation control and containment conditions. The variables and alarm legs of each critical function of the PGSFR are as follows; - Reactivity control: The variables of reactivity control function are power range neutron flux instrumentation, intermediate range neutron flux instrumentation, source range neutron flux instrumentation, and control rod bottom contacts. The alarm leg to display the reactivity controls consists of status of control drop malfunction, high post trip power and thermal reactivity addition. - Reactor core cooling: The variables are PHTS sodium level, hot pool temperature of PHTS, subassembly exit temperature, cold pool temperature of the PHTS, PHTS pump current, and PHTS pump breaker status. The alarm leg consists of high core delta temperature, low sodium level of the PHTS, high subassembly exit temperature, and low PHTS pump load. - Reactor coolant system integrity: The variables are PHTS sodium level, cover gas pressure, and safeguard vessel sodium level. The alarm leg is composed of low sodium level of PHTS, high cover gas pressure and high sodium level of the safety guard vessel. - PHTS heat removal: The variables are PHTS sodium level, hot pool temperature of PHTS, core exit temperature, cold pool temperature of the PHTS, flow rate of passive residual heat removal system

  8. Model of critical diagnostic reasoning: achieving expert clinician performance.

    Science.gov (United States)

    Harjai, Prashant Kumar; Tiwari, Ruby

    2009-01-01

    Diagnostic reasoning refers to the analytical processes used to determine patient health problems. While the education curriculum and health care system focus on training nurse clinicians to accurately recognize and rescue clinical situations, assessments of non-expert nurses have yielded less than satisfactory data on diagnostic competency. The contrast between the expert and non-expert nurse clinician raises the important question of how differences in thinking may contribute to a large divergence in accurate diagnostic reasoning. This article recognizes superior organization of one's knowledge base, using prototypes, and quick retrieval of pertinent information, using similarity recognition as two reasons for the expert's superior diagnostic performance. A model of critical diagnostic reasoning, using prototypes and similarity recognition, is proposed and elucidated using case studies. This model serves as a starting point toward bridging the gap between clinical data and accurate problem identification, verification, and management while providing a structure for a knowledge exchange between expert and non-expert clinicians.

  9. A Study on Relationships between Functional Performance and Task Performance Measure through Experiments in NPP MCR

    International Nuclear Information System (INIS)

    Jang, In Seok; Seong, Poong Hyun; Park, Jin Kyun

    2011-01-01

    Further improvements in levels of organization, management, man-machine interfaces, education, training, etc. are required, if high operating reliability of operators in huge and complex plants such as chemical plants and electrical power generating plants is to be maintained. Improvement requires good understanding of operators' behavior, including defining what is good performance for operators, especially in emergency situations. Human performance measures, therefore, are important to enhance performance and to reduce the probability of incidents and accidents in Nuclear Power Plants (NPPs). Operators' performance measures are used for multi-objectives such as control room design, human system interface evaluation, training, procedure and so on. There are two kinds of representative methods to measure operators' performance. These methods are now known as the functional performance measure and task performance measure. Functional performance measures are basically based on the plant process parameters. Functional performance measures indicate how well the operators controlled selected critical parameters. The parameters selected in this paper are derived from the four Critical Safety Functions (CSFs) identified in the emergency operating procedures such as achievement of subcriticality, maintenance of core cooling, maintenance of heat sink and maintenance of containment integrity. Task performance measures are based on the task analysis. Task analysis is to determine the tasks required and how operators are performed. In this paper, task analysis is done with ideal path for an accident completed by experts and Emergency Operation Procedure (EOP). However, most literatures related to operators' performance have been using one of these measures and there is no research to find out the relationships between two measures. In this paper, the relationships between functional performance measure and task performance measure are investigated using experiments. Shortly

  10. Critical speed as a predictor of aerobic performance in children

    Directory of Open Access Journals (Sweden)

    Wagner de Campos

    2007-03-01

    Full Text Available To compare times achieved in a 1,600m rural road run with the times predicted from critical speed, in additionto verify any association between critical speed and VO2max with the aerobic performance (1,600m time of children. The sample consisted of 25 boys and 39 girls, aged 9 to 11 years. Their critical speeds were determined using the work versus time model, performed in the 200m and 800m maximum runs. The value of VO2max was measured using a 20-meter shuttlerun test. Endurance performance was determinate from the time obtained in a rural 1,600m road run. Statistical proceduresused were descriptive analyses, Student’s t test and Pearson’s moment correlation, with signifi cance level set at p RESUMO O estudo teve como objetivo comparar o tempo obtido na prova de 1.600m com o tempo predito pela velocidade crítica, bem como verifi car a associação da velocidade crítica e da potência aeróbia (VO2máx com o desempenho aeróbio (tempo 1.600m em crianças. A amostra foi composta de 25 meninos e 39 meninas, com faixa etária entre 9 a 11 anos, classifi cadas nos estágios de maturação sexual 1 e 2 de Tanner. A velocidade crítica foi obtida pelo modelo de avaliação trabalho versus tempo, na realização de dois tiros máximos de 200m e 800m. O VO2máx foi obtido através do teste de vai-vem de 20m. O desempenho aeróbio foi obtido através do tempo de percurso em uma prova rústica de 1.600m. Utilizou-se a estatística descritiva, teste “t” student e a correlação de Pearson, adotando p<0,05. Em ambos os grupos, odesempenho obtido na prova de 1.600m foi significativamente menor que o desempenho predito pela velocidade crítica (masculino: 8,43 ± 0,78 min versus 10,16 ± 1,37 min; feminino: 9,09 ± 0,75 min versus 10,30 ± 1,09 min (p= 0,0001.Observaram-se correlações inversamente significativas entre a velocidade crítica e o desempenho aeróbio nos grupos masculino e feminino (r= -0,52 e r= -0,70, respectivamente, e entre o VO2m

  11. Two-Phase Iteration for Value Function Approximation and Hyperparameter Optimization in Gaussian-Kernel-Based Adaptive Critic Design

    OpenAIRE

    Chen, Xin; Xie, Penghuan; Xiong, Yonghua; He, Yong; Wu, Min

    2015-01-01

    Adaptive Dynamic Programming (ADP) with critic-actor architecture is an effective way to perform online learning control. To avoid the subjectivity in the design of a neural network that serves as a critic network, kernel-based adaptive critic design (ACD) was developed recently. There are two essential issues for a static kernel-based model: how to determine proper hyperparameters in advance and how to select right samples to describe the value function. They all rely on the assessment of sa...

  12. Productive criticism, Part 2: A new environment for criticism. Performance appraisals and other real-life situations.

    Science.gov (United States)

    Weisinger, H D

    1996-01-01

    Criticism affects almost all aspects of your job: the quality of work you do, how you feel about it, and your relationships with your boss, coworkers, and subordinates. Used productively, criticism is a powerful tool that helps you improve your work, enhance your working relationships, increase your job satisfaction, and achieve better overall results. Improperly used, it impedes performance, demoralizes you, discourages you from wanting to try again, and creates friction in the workplace. In short, the ability to give and take criticism significantly determines how well you do on the job. In Part 1, we explained how to use productive criticism as an opportunity for the growth and education of subordinates. In Part 2, we will examine how you can productively criticize superiors and peers. We will also offer new performance appraisal technics and examine real-life criticism situations.

  13. Summary of functional and performance test procedures

    DEFF Research Database (Denmark)

    Mitzel, Jens; Gülzow, Erich; Friedrich, K. Andreas

    Different Test Modules (TM) are defined for the functional and performance characterization of a PEMFC stack. The master document TM2.00 defines requirements and methodology for parameter variation, stability and data acquisition.......Different Test Modules (TM) are defined for the functional and performance characterization of a PEMFC stack. The master document TM2.00 defines requirements and methodology for parameter variation, stability and data acquisition....

  14. Critical Thinking in a Higher Education Functional English Course

    Science.gov (United States)

    Khan, Shaista Irshad

    2017-01-01

    Critical thinking is seen as a highly desirable way of thinking that needs to be encouraged in all areas of higher education. However, it is not easy to conceptualise critical thinking in ways that can help in its development and in its assessment. Recent policy documents in Pakistan have laid emphasis on the development of critical thinking…

  15. Does mindfulness enhance critical thinking? Evidence for the mediating effects of executive functioning in the relationship between mindfulness and critical thinking

    Directory of Open Access Journals (Sweden)

    Chris eNoone

    2016-01-01

    Full Text Available Mindfulness originated in the Buddhist tradition as a way of cultivating clarity of thought. Despite the fact that this behaviour is best captured using critical thinking assessments, no studies have examined the effects of mindfulness on critical thinking or the mechanisms underlying any such possible relationship. Even so, mindfulness has been suggested as being beneficial for critical thinking in higher education. Critical thinking is recognised as an important higher-order cognitive process which involves the ability to analyse and evaluate evidence and arguments. Such non-automatic, reflective responses generally require the engagement of executive functioning which includes updating, inhibition and shifting of representations in working memory. Based on research showing that mindfulness enhances aspects of executive functioning and certain higher-order cognitive processes, we hypothesised that individuals higher in facets of dispositional mindfulness would demonstrate greater critical thinking performance, and that this relationship would be mediated by executive functioning. Cross-sectional assessment of these constructs in a sample of 178 university students was achieved using the observing and non-reactivity sub-scales of the Five Factor Mindfulness Questionnaire, a battery of executive functioning tasks and the Halpern Critical Thinking Assessment. Our hypotheses were tested by constructing a multiple meditation model which was analysed using Structural Equation Modelling. Evidence was found for inhibition mediating the relationships between both observing and non-reactivity and critical thinking in different ways. Indirect-only (or full mediation was demonstrated for the relationship between observing, inhibition and critical thinking. Competitive mediation was demonstrated for the relationship between non-reactivity, inhibition and critical thinking. This suggests additional mediators of the relationship between non-reactivity and

  16. Judicial Performance Review in Arizona: A Critical Assessment

    Directory of Open Access Journals (Sweden)

    Rebecca White Berch

    2014-12-01

    Full Text Available Judicial performance evaluations are a relatively new tool for assessing judges and providing information to voters to help them determine whether to retain judges in contested or retention elections. Arizona implemented its judicial evaluation program about 20 years ago, and since that time, the state has continually strived to improve its process. The result is that today Arizona has one of the most progressive and comprehensive judicial performance evaluation programs in the United States. This article takes a critical look at the strengths and weaknesses of Arizona’s program, keeping in mind two key values that the system seeks to protect: judicial accountability and judicial independence. Las evaluaciones del rendimiento judicial son una herramienta relativamente nueva para evaluar a los jueces y ofrecer información a los votantes, que les ayude a decidir si quieren reelegir a los jueces en las elecciones. Arizona implementó su programa de evaluación judicial hace unos 20 años, y desde ese momento, el Estado se ha esforzado continuamente en mejorar el proceso. El resultado es que hoy en día, Arizona tiene uno de los programas de evaluación del rendimiento judicial más progresistas e integrales de los Estados Unidos. Este artículo ofrece una mirada crítica a las fortalezas y debilidades del programa de Arizona, teniendo en cuenta dos valores clave que el sistema trata de proteger: la responsabilidad judicial y la independencia judicial. DOWNLOAD THIS PAPER FROM SSRN: http://ssrn.com/abstract=2533868

  17. Function Follows Performance in Evolutionary Computational Processing

    DEFF Research Database (Denmark)

    Pasold, Anke; Foged, Isak Worre

    2011-01-01

    As the title ‘Function Follows Performance in Evolutionary Computational Processing’ suggests, this paper explores the potentials of employing multiple design and evaluation criteria within one processing model in order to account for a number of performative parameters desired within varied...

  18. Functional Task Test: 1. Sensorimotor changes Associated with Postflight Alterations in Astronaut Functional Task Performance

    Science.gov (United States)

    Bloomberg, J. J.; Arzeno, N. H.; Buxton, R. E.; Feiveson, A. H.; Kofman, I. S.; Lee, S. M. C.; Miller, C. A.; Mulavara, A. P.; Platts, S. H.; Peters, B. T.; hide

    2011-01-01

    Space flight is known to cause alterations in multiple physiological systems including changes in sensorimotor, cardiovascular, and neuromuscular systems. These changes may affect a crewmember s ability to perform critical mission tasks immediately after landing on a planetary surface. The overall goal of this project is to determine the effects of space flight on functional tests that are representative of high priority exploration mission tasks and to identify the key underlying physiological factors that contribute to decrements in performance. This presentation will focus on the sensorimotor contributions to postflight functional performance.

  19. Atypical E2f functions are critical for pancreas polyploidization.

    Directory of Open Access Journals (Sweden)

    Ramadhan B Matondo

    Full Text Available The presence of polyploid cells in the endocrine and exocrine pancreas has been reported for four decades. In rodents, pancreatic polyploidization is initiated after weaning and the number of polyploid cells increases with age. Surprisingly the molecular regulators and biological functions of polyploidization in the pancreas are still unknown. We discovered that atypical E2f activity is essential for polyploidization in the pancreas, using an inducible Cre/LoxP approach in new-born mice to delete ubiquitously the atypical E2f transcription factors, E2f7 and E2f8. In contrast to its critical role in embryonic survival, conditional deletion of both of both atypical E2fs in newborn mice had no impact on postnatal survival and mice lived until old age. However, deficiency of E2f7 or E2f8 alone was sufficient to suppress polyploidization in the pancreas and associated with only a minor decrease in blood serum levels of glucose, insulin, amylase and lipase under 4 hours starvation condition compared to wildtype littermates. In mice with fewer pancreatic polyploid cells that were fed ad libitum, no major impact on hormones or enzymes levels was observed. In summary, we identified atypical E2fs to be essential for polyploidization in the pancreas and discovered that postnatal induced loss of both atypical E2fs in many organs is compatible with life until old age.

  20. Atypical E2f functions are critical for pancreas polyploidization.

    Science.gov (United States)

    Matondo, Ramadhan B; Moreno, Eva; Toussaint, Mathilda J M; Tooten, Peter C J; van Essen, Saskia C; van Liere, Elsbeth A; Youssef, Sameh A; Bongiovanni, Laura; de Bruin, Alain

    2018-01-01

    The presence of polyploid cells in the endocrine and exocrine pancreas has been reported for four decades. In rodents, pancreatic polyploidization is initiated after weaning and the number of polyploid cells increases with age. Surprisingly the molecular regulators and biological functions of polyploidization in the pancreas are still unknown. We discovered that atypical E2f activity is essential for polyploidization in the pancreas, using an inducible Cre/LoxP approach in new-born mice to delete ubiquitously the atypical E2f transcription factors, E2f7 and E2f8. In contrast to its critical role in embryonic survival, conditional deletion of both of both atypical E2fs in newborn mice had no impact on postnatal survival and mice lived until old age. However, deficiency of E2f7 or E2f8 alone was sufficient to suppress polyploidization in the pancreas and associated with only a minor decrease in blood serum levels of glucose, insulin, amylase and lipase under 4 hours starvation condition compared to wildtype littermates. In mice with fewer pancreatic polyploid cells that were fed ad libitum, no major impact on hormones or enzymes levels was observed. In summary, we identified atypical E2fs to be essential for polyploidization in the pancreas and discovered that postnatal induced loss of both atypical E2fs in many organs is compatible with life until old age.

  1. Assessing Critical Thinking Performance of Postgraduate Students in Threaded Discussions

    Science.gov (United States)

    Tan, Cheng Lee; Ng, Lee Luan

    2014-01-01

    Critical thinking has increasingly been seen as one of the important attributes where human capital is concerned and in line with this recognition, the tertiary educational institutions worldwide are putting more effort into designing courses that produce university leavers who are critical thinkers. This study aims to investigate the critical…

  2. A critical perspective on the measurement of performance in the empirical multinationality and performance literature

    DEFF Research Database (Denmark)

    Richter, Nicole Franziska; Schmidt, Robert; Ladwig, Tina J.

    2017-01-01

    used in empirical studies and the underlying theoretical streams that explain the effects on benefits and costs of multinationality. Our findings indicate that authors still largely rely on overall financial performance measures. Theoretical arguments, in contrast, refer to specific benefit and cost......This paper contributes to the core research in international business (IB), namely the relation between multinationality and performance, and is concerned with the quality of past empirical research designs. On the basis of 49 studies, we critically evaluate the match between performance measures...... positions that are better reflected in operational performance indicators. In our view, the idiosyncratic choice of the performance measures contributes to the varying results in past studies. We offer suggestions for improving future research designs....

  3. Patient Experience: A Critical Indicator of Healthcare Performance.

    Science.gov (United States)

    Guler, Pamela H

    2017-01-01

    Patient experience has become a critical differentiator for healthcare organizations, and it will only grow in importance as transparency and consumerism dominate the healthcare landscape. Creating and sustaining a consistently exceptional experience that promotes patient engagement and the best outcomes is far more than just "satisfying" patients, going well beyond amenities that may be provided.Perception of care experience is often shaped by methods we use to address the biopsychosocial needs of patients. Building relationships and communicating well with our patients and families are primary approaches. In a complex healthcare situation, patients may not fully understand or remember the highly clinical nature of treatment. However, they always remember how we made them feel, how we communicated with them as a team, and what interactions they experienced while in our care.Patients who are fully informed and feel connected to their caregivers are often less anxious than those who are disengaged. Informed and engaged patients are enabled to participate in their healthcare. Organizations that focus on developing an accountable culture-one that inspires caregivers to communicate in a way that connects to patients' mind, body, and spirit while leveraging standard, evidence-based patient experience practices-find that patients' perception of care, or "the patient experience," is vastly improved.Adventist Health System has embarked on a journey to patient experience excellence with a commitment to whole-person care and standard patient experience practice across the system. Recognized with several national awards, we continue to strengthen our approach toward bringing all of our campuses and patient settings to sustained high-level performance. We have found that a combination of strong, accountable leadership; a focus on employee culture; engagement of physicians; standardized patient experience practices and education; and meaningful use of patient feedback are top

  4. Dry critical experiments and analyses performed in support of the Topaz-2 Safety Program

    International Nuclear Information System (INIS)

    Pelowitz, D.B.; Sapir, J.; Glushkov, E.S.; Ponomarev-Stepnoi, N.N.; Bubelev, V.G.; Kompanietz, G.B.; Krutov, A.M.; Polyakov, D.N.; Loynstev, V.A.

    1994-01-01

    In December 1991, the Strategic Defense Initiative Organization decided to investigate the possibility of launching a Russian Topaz-2 space nuclear power system. Functional safety requirements developed for the Topaz mission mandated that the reactor remain subcritical when flooded and immersed in water. Initial experiments and analyses performed in Russia and the United States indicated that the reactor could potentially become supercritical in several water- or sand-immersion scenarios. Consequently, a series of critical experiments was performed on the Narciss M-II facility at the Kurchatov Institute to measure the reactivity effects of water and sand immersion, to quantify the effectiveness of reactor modifications proposed to preclude criticality, and to benchmark the calculational methods and nuclear data used in the Topaz-2 safety analyses. In this paper we describe the Narciss M-II experimental configurations along with the associated calculational models and methods. We also present and compare the measured and calculated results for the dry experimental configurations

  5. Criticality accident studies and research performed in the Valduc criticality laboratory, France

    International Nuclear Information System (INIS)

    Barbry, F.; Fouillaud, P.

    2001-01-01

    In 1967, the IPSN (Institut de Protection et de Surete Nucleaire - Nuclear Protection and Safety Institute) started studies and research in France on criticality accidents, with the objective of improving knowledge and modelling of accidents in order to limit consequences to the public, the environment and installations. The criticality accident is accompanied by an intense emission of neutronic and gamma radiation and releases of radioactive products in the form of gas and aerosols, generating irradiation and contamination risks. The main objectives of the studies carried out, particularly using the CRAC installation and the SILENE reactor at Valduc (France), were to model the physics of criticality accidents, to estimate the risks of irradiation and radioactive releases, to elaborate an accident detection system and to provide information for intervention plans. This document summarizes the state of knowledge in the various fields mentioned above. The results of experiments carried out in the Valduc criticality laboratory are used internationally as reference data for the qualification of calculation codes and the assessment of the consequences of a criticality accident. The SILENE installation, that reproduces the various conditions encountered during a criticality accident, is also a unique international research tool for studies and training on those matters. (author)

  6. Critical periods of brain growth and cognitive function in children.

    Science.gov (United States)

    Gale, Catharine R; O'Callaghan, Finbar J; Godfrey, Keith M; Law, Catherine M; Martyn, Christopher N

    2004-02-01

    There is evidence that IQ tends to be higher in those who were heavier at birth or who grew taller in childhood and adolescence. Although these findings imply that growth in both foetal and postnatal life influences cognitive performance, little is known about the relative importance of brain growth during different periods of development. We investigated the relationship between brain growth in different periods of pre- and postnatal life and cognitive function in 221 9-year-old children whose mothers had taken part in a study of nutrition in pregnancy and whose head circumference had been measured at 18 weeks gestation, birth and 9 months of age. Cognitive function of the children and their mothers was assessed with the Wechsler Abbreviated Scale of Intelligence. Full-scale IQ at age 9 years rose by 1.98 points [95% confidence interval (CI) 0.34 to 3.62] for each SD increase in head circumference at 9 months and by 2.87 points (95% CI 1.05 to 4.69) for each SD increase in head circumference at 9 years of age, after adjustment for sex, number of older siblings, maternal IQ, age, education, social class, duration of breastfeeding and history of low mood in the post-partum period. Postnatal head growth was significantly greater in children whose mothers were educated to degree level or of higher socio-economic status. There was no relation between IQ and measurements of head size at 18 weeks gestation or at birth. These results suggest that brain growth during infancy and early childhood is more important than growth during foetal life in determining cognitive function.

  7. Innovation and organisational performance: A critical review of the instruments used to measure organisational performance

    Directory of Open Access Journals (Sweden)

    Tebogo Sethibe

    2016-10-01

    Full Text Available Background: Innovation is recognised as one of the most important determinant of organisational performance. Yet, the results of studies that investigate the relationship between innovation and organisational performance are inconclusive. The inconsistency has been attributed to a number of factors, which include, among others, the measures used to evaluate organisational performance. Aim: This study was set out to identify, categorise and critically analyse the instruments used to assess organisational performance when investigating the relationship between innovation and organisational performance. Setting: The study focuses on all scientific publications reporting on organisational performance, inclusive of both financial and non-financial indicators of performance, and are not limited to any specific country or industry. Methods: The systematic literature review methodology was used to identify studies which investigated the relationship between innovation and organisational performance. Once identified, articles were analysed on the way organisational performance was measured. Classification was done with reference to financial and non-financial indicators, accounting and market-based, as well as objective and subjective measures. Results: The findings show that profitability, sales growth and return on assets (ROA are the most preferred accounting-based financial measures of organisation performance. In addition, Tobin’s Q was found to be the most favoured market-based financial measure of organisational performance. The study further reveals that market share, customer satisfaction and productivity are the most popular non-financial-based measures of organisational performance. Conclusion: The use of measures of organisational performance is often left to the discussion of the researcher, which is not implicitly wrong, but does little to contribute to the body of knowledge on this important topic. Researchers are firstly urged to

  8. Pulmonary Function Affects Language Performance in Aging

    Directory of Open Access Journals (Sweden)

    Lewina O Lee

    2014-04-01

    Full Text Available Background Good pulmonary function (PF is associated with preservation of cognitive performance, primarily of executive functions, in aging (Albert et al., 1995; Chyou et al., 1996; Emery, Finkel, & Pedersen, 2012; Yohannes & Gindo, 2013. The contribution of PF to older adults’ language abilities, however, has never been explored, to our knowledge. We addressed this gap by examining the effects of PF on older adults’ language functions, as measured by naming and sentence processing accuracy. We predicted similar effects as found for executive functions, given the positive associations between executive functions and sentence processing in aging (e.g., Goral et al., 2011. Methods Data were collected from 190 healthy adults aged 55 to 84 years (M = 71.1, SD = 8.1, with no history of neurological or psychiatric disorders. Procedure PF was measured prior to language testing. Measures included forced expiratory volume in 1 second (FEV1 and forced vital capacity (FVC. Language functions were assessed through performance on computer-administered lexical retrieval and sentence processing tasks. Sentence processing was measured using two auditory comprehension tasks: one, of embedded sentences (ES, the other, of sentences with multiple negatives (MN. Lexical retrieval was measured using the Boston Naming Test (BNT and Action Naming Test (ANT. Performance was scored for percent accuracy. Additionally, lexical retrieval was evaluated with a phonemic fluency task (FAS, which also taps executive function abilities. Statistical Analyses Multiple regression was used to examine the association between pulmonary and language functions, adjusting for age, education, gender, history of respiratory illness, current level of physical activities, and current and past smoking. Results Better PF was associated with better sentence processing and lexical retrieval on naming tasks, but not with phonemic fluency, after adjusting for covariates. Higher FVC was

  9. Growth factor choice is critical for successful functionalization of nanoparticles

    Directory of Open Access Journals (Sweden)

    Josephine ePinkernelle

    2015-09-01

    Full Text Available Nanoparticles (NPs show new characteristics compared to the corresponding bulk material. These nanoscale properties make them interesting for various applications in biomedicine and life sciences. One field of application is the use of magnetic NPs to support regeneration in the nervous system. Drug delivery requires a functionalization of NPs with bio-functional molecules. In our study, we functionalized self-made PEI-coated iron oxide NPs with nerve growth factor (NGF and glial cell-line derived neurotrophic factor (GDNF. Next, we tested the bio-functionality of NGF in a rat pheochromocytoma cell line (PC12 and the bio-functionality of GDNF in an organotypic spinal cord culture. Covalent binding of NGF to PEI-NPs impaired bio-functionality of NGF, but non-covalent approach differentiated PC12 cells reliably. Non-covalent binding of GDNF showed a satisfying bio-functionality of GDNF:PEI-NPs, but turned out to be instable in conjugation to the PEI-NPs. Taken together, our study showed the importance of assessing bio-functionality and binding stability of functionalized growth factors using proper biological models. It also shows that successful functionalization of magnetic NPs with growth factors is dependent on the used binding chemistry and that it is hardly predictable. For use as therapeutics, functionalization strategies have to be reproducible and future studies are needed.

  10. Altered Functional Performance in Patients with Fibromyalgia

    OpenAIRE

    Costa, Isis da Silva; Gamund?, Antoni; Miranda, Jos? G. Vivas; Fran?a, Lucas G. Souza; De Santana, Charles Novaes; Montoya, Pedro

    2017-01-01

    Fibromyalgia is a common chronic pain condition that exerts a considerable impact on patients' daily activities and quality of life. Objectives: The main objective of the present study was to evaluate kinematic parameters of gait, functional performance, and balance in women with fibromyalgia syndrome. Methods: The study included 26 female patients with fibromyalgia (49.2 ± 8.0 years) according to the criteria of the American College of Rheumatology, as well as 16 pain-free women (43.5 ...

  11. Understanding Resident Performance, Mindfulness, and Communication in Critical Care Rotations.

    Science.gov (United States)

    Real, Kevin; Fields-Elswick, Katelyn; Bernard, Andrew C

    Evidence from the medical literature suggests that surgical trainees can benefit from mindful practices. Surgical educators are challenged with the need to address resident core competencies, some of which may be facilitated by higher levels of mindfulness. This study explores whether mindful residents perform better than their peers as members of the health care team. This study employed a multiphase, multimethod design to assess resident mindfulness, communication, and clinical performance. Academic, tertiary medical center. Residents (N = 51) working in an intensive care unit. In phase I, medical residents completed a self-report survey of mindfulness, communication, emotional affect, and clinical decision-making. In phase II, resident performance was assessed using independent ratings of mindfulness and clinical decision-making by attending physicians and registered nurses. In phase 1, a significant positive relationship was found between resident performance and mindfulness, positive affect (PA), and communication. In phase 2, attending physicians/registered nurses' perceptions of residents' mindfulness were positively correlated with communication and inversely related to negative affect (NA). The top quartile of residents for performance and mindfulness had the lowest NA. Higher-rated residents underestimated their performance/mindfulness, whereas those in the lowest quartile overestimated these factors. This study offers a number of implications for medical resident education. First, mindfulness was perceived to be a significant contributor to self-assessments of competency and performance. Second, both PA and NA were important to mindfulness and performance. Third, communication was associated with resident performance, mindfulness, and PA. These implications suggest that individual characteristics of mindfulness, communication, and affect, all potentially modifiable, influence care quality and safety. To improve low performers, surgical educators could

  12. Understanding adolescents' sleep patterns and school performance: a critical appraisal.

    Science.gov (United States)

    Wolfson, Amy R; Carskadon, Mary A

    2003-12-01

    The present paper reviews and critiques studies assessing the relation between sleep patterns, sleep quality, and school performance of adolescents attending middle school, high school, and/or college. The majority of studies relied on self-report, yet the researchers approached the question with different designs and measures. Specifically, studies looked at (1) sleep/wake patterns and usual grades, (2) school start time and phase preference in relation to sleep habits and quality and academic performance, and (3) sleep patterns and classroom performance (e.g., examination grades). The findings strongly indicate that self-reported shortened total sleep time, erratic sleep/wake schedules, late bed and rise times, and poor sleep quality are negatively associated with academic performance for adolescents from middle school through the college years. Limitations of the current published studies are also discussed in detail in this review.

  13. Critical role of bicarbonate and bicarbonate transporters in cardiac function

    OpenAIRE

    Wang, Hong-Sheng; Chen, Yamei; Vairamani, Kanimozhi; Shull, Gary E

    2014-01-01

    Bicarbonate is one of the major anions in mammalian tissues and extracellular fluids. Along with accompanying H+, HCO3- is generated from CO2 and H2O, either spontaneously or via the catalytic activity of carbonic anhydrase. It serves as a component of the major buffer system, thereby playing a critical role in pH homeostasis. Bicarbonate can also be utilized by a variety of ion transporters, often working in coupled systems, to transport other ions and organic substrates across cell membrane...

  14. Altered Functional Performance in Patients with Fibromyalgia.

    Science.gov (United States)

    Costa, Isis da Silva; Gamundí, Antoni; Miranda, José G Vivas; França, Lucas G Souza; De Santana, Charles Novaes; Montoya, Pedro

    2017-01-01

    Fibromyalgia is a common chronic pain condition that exerts a considerable impact on patients' daily activities and quality of life. Objectives: The main objective of the present study was to evaluate kinematic parameters of gait, functional performance, and balance in women with fibromyalgia syndrome. Methods: The study included 26 female patients with fibromyalgia (49.2 ± 8.0 years) according to the criteria of the American College of Rheumatology, as well as 16 pain-free women (43.5 ± 8.5 years). Gait and balance parameters were extracted from video recordings of participants performing several motor tasks. Non-linear dynamic of body sway time series was also analyzed by computing the Hurst exponent. In addition, functional performance and clinical pain were obtained by using standardized motor tests (Berg's balance scale, 6-min walking test, timed up and go task, Romberg's balance test) and self-report questionnaires (Fibromyalgia Impact Questionnaire). Results: Walking speed was significantly diminished ( p fibromyalgia and pain-free controls on body sway in the medial-lateral and anterior-posterior axes (all ps gait and balance were significantly associated with high levels of pain, depression, stiffness, anxiety, and fatigue in fibromyalgia. Conclusion: Our data revealed that both gait and balance were severely impaired in FM, and that subjective complaints associated with FM could contribute to functional disability in these patients. These findings suggest that optimal rehabilitation and fall prevention in fibromyalgia require a comprehensive assessment of both psychological responses to pain and physical impairments during postural control and gait.

  15. Permanent isolation surface barrier: Functional performance

    International Nuclear Information System (INIS)

    Wing, N.R.

    1993-10-01

    This document presents the functional performance parameters for permanent isolation surface barriers. Permanent isolation surface barriers have been proposed for use at the Hanford Site (and elsewhere) to isolate and dispose of certain types of waste in place. Much of the waste that would be disposed of using in-place isolation techniques is located in subsurface structures, such as solid waste burial grounds, tanks, vaults, and cribs. Unless protected in some way, the wastes could be transported to the accessible environment via transport pathways, such as water infiltration, biointrusion, wind and water erosion, human interference, and/or gaseous release

  16. The Green's function method for critical heterogeneous slabs

    International Nuclear Information System (INIS)

    Kornreich, D.E.

    1996-01-01

    Recently, the Green's Function Method (GFM) has been employed to obtain benchmark-quality results for nuclear engineering and radiative transfer calculations. This was possible because of fast and accurate calculations of the Green's function and the associated Fourier and Laplace transform inversions. Calculations have been provided in one-dimensional slab geometries for both homogeneous and heterogeneous media. A heterogeneous medium is analyzed as a series of homogeneous slabs, and Placzek's lemma is used to extend each slab to infinity. This allows use of the infinite medium Green's function (the anisotropic plane source in an infinite homogeneous medium) in the solution. To this point, a drawback of the GFM has been the limitation to media with c 1; however, mathematical solutions exist which result in oscillating Green's functions. Such calculations are briefly discussing. The limitation to media with c < 1 has been relaxed so that the Green's function may also be calculated for media with c ≥ 1. Thus, materials that contain fissionable isotopes may be modeled

  17. Productivity Implications of Employee Performance Appraisal System : A Critical Survey.

    OpenAIRE

    Dr. VSR Subramaniam

    2004-01-01

    The Productivity of any organisation is directly correlated to the Effectiveness of the Employee Performance Appraisal System, subject to the Effectiveness of the Support Systems, depending upon the type of organizational business. INFERENCE : Technology, Systems and Manpower are linked in an inter- related circle focusing towards Productivity =============================================================== DOCTORAL (Ph.D) RESEARCH WORK OF DR.VSR.SUBRAMANIAM IN JAMNALAL BAJAJ INSTITUTE OF MANA...

  18. Simulated front crawl swimming performance related to critical speed and critical power

    NARCIS (Netherlands)

    Toussaint, H.M.; Wakayoshi, K.; Hollander, A.P.; Ogita, F.

    1998-01-01

    Purpose: Competitive pool swimming events range in distance from 50 to 1500 m. Given the difference in performance times (±23-1000 s), the contribution of the aerobic and anaerobic energy systems changes considerably with race distance. In training practice the regression line between swimming

  19. Impact of Hypobarism During Simulated Transport on Critical Care Air Transport Team Performance

    Science.gov (United States)

    2017-04-26

    AFRL-SA-WP-SR-2017-0008 Impact of Hypobarism During Simulated Transport on Critical Care Air Transport Team Performance Dina...July 2014 – November 2016 4. TITLE AND SUBTITLE Impact of Hypobarism During Simulated Transport on Critical Care Air Transport Team Performance 5a...During Critical Care Air Transport Team Advanced Course validation, three-member teams consisting of a physician, nurse, and respiratory therapist

  20. Is Critical Thinking a Mediator Variable of Student Performance in School?

    Science.gov (United States)

    Walter, Christel; Walter, Paul

    2018-01-01

    The study explores the influences of critical thinking and interests on students' performance at school. The tested students attended German grammar schools ("Gymnasien"). Separate regression analyses showed the expected moderate positive influences of critical thinking and interests on school performance. But analyzed simultaneously,…

  1. Identifying reverse 3PL performance critical success factors

    OpenAIRE

    Sharif, A M

    2009-01-01

    The reverse and third party logistics operational process is now well known and established to be a vital component of modern day supply chain and product / service-based organizations (Marasco, 2007). Apart from being a vital component of such enterprises, many researchers and practitioners have also been noting the importance of this approach and its impact on customer service, satisfaction, profitability and other key performance indicators (Autry et al., 2001). However, studies relating t...

  2. Critical thinking skills in nursing students: comparison of simulation-based performance with metrics

    Science.gov (United States)

    Fero, Laura J.; O’Donnell, John M.; Zullo, Thomas G.; Dabbs, Annette DeVito; Kitutu, Julius; Samosky, Joseph T.; Hoffman, Leslie A.

    2018-01-01

    Aim This paper is a report of an examination of the relationship between metrics of critical thinking skills and performance in simulated clinical scenarios. Background Paper and pencil assessments are commonly used to assess critical thinking but may not reflect simulated performance. Methods In 2007, a convenience sample of 36 nursing students participated in measurement of critical thinking skills and simulation-based performance using videotaped vignettes, high-fidelity human simulation, the California Critical Thinking Disposition Inventory and California Critical Thinking Skills Test. Simulation- based performance was rated as ‘meeting’ or ‘not meeting’ overall expectations. Test scores were categorized as strong, average, or weak. Results Most (75·0%) students did not meet overall performance expectations using videotaped vignettes or high-fidelity human simulation; most difficulty related to problem recognition and reporting findings to the physician. There was no difference between overall performance based on method of assessment (P = 0·277). More students met subcategory expectations for initiating nursing interventions (P ≤ 0·001) using high-fidelity human simulation. The relationship between video-taped vignette performance and critical thinking disposition or skills scores was not statistically significant, except for problem recognition and overall critical thinking skills scores (Cramer’s V = 0·444, P = 0·029). There was a statistically significant relationship between overall high-fidelity human simulation performance and overall critical thinking disposition scores (Cramer’s V = 0·413, P = 0·047). Conclusion Students’ performance reflected difficulty meeting expectations in simulated clinical scenarios. High-fidelity human simulation performance appeared to approximate scores on metrics of critical thinking best. Further research is needed to determine if simulation-based performance correlates with critical thinking skills

  3. Critical thinking skills in nursing students: comparison of simulation-based performance with metrics.

    Science.gov (United States)

    Fero, Laura J; O'Donnell, John M; Zullo, Thomas G; Dabbs, Annette DeVito; Kitutu, Julius; Samosky, Joseph T; Hoffman, Leslie A

    2010-10-01

    This paper is a report of an examination of the relationship between metrics of critical thinking skills and performance in simulated clinical scenarios. Paper and pencil assessments are commonly used to assess critical thinking but may not reflect simulated performance. In 2007, a convenience sample of 36 nursing students participated in measurement of critical thinking skills and simulation-based performance using videotaped vignettes, high-fidelity human simulation, the California Critical Thinking Disposition Inventory and California Critical Thinking Skills Test. Simulation-based performance was rated as 'meeting' or 'not meeting' overall expectations. Test scores were categorized as strong, average, or weak. Most (75.0%) students did not meet overall performance expectations using videotaped vignettes or high-fidelity human simulation; most difficulty related to problem recognition and reporting findings to the physician. There was no difference between overall performance based on method of assessment (P = 0.277). More students met subcategory expectations for initiating nursing interventions (P ≤ 0.001) using high-fidelity human simulation. The relationship between videotaped vignette performance and critical thinking disposition or skills scores was not statistically significant, except for problem recognition and overall critical thinking skills scores (Cramer's V = 0.444, P = 0.029). There was a statistically significant relationship between overall high-fidelity human simulation performance and overall critical thinking disposition scores (Cramer's V = 0.413, P = 0.047). Students' performance reflected difficulty meeting expectations in simulated clinical scenarios. High-fidelity human simulation performance appeared to approximate scores on metrics of critical thinking best. Further research is needed to determine if simulation-based performance correlates with critical thinking skills in the clinical setting. © 2010 The Authors. Journal of Advanced

  4. Atypical E2f functions are critical for pancreas polyploidization

    NARCIS (Netherlands)

    Matondo, Ramadhan B; Moreno, Eva; Toussaint, Mathilda J M; Tooten, Peter C J; van Essen, Saskia C; van Liere, Elsbeth A; Youssef, Sameh A; Bongiovanni, Laura; de Bruin, Alain

    2018-01-01

    The presence of polyploid cells in the endocrine and exocrine pancreas has been reported for four decades. In rodents, pancreatic polyploidization is initiated after weaning and the number of polyploid cells increases with age. Surprisingly the molecular regulators and biological functions of

  5. Perceptions of nursing students after performing an individual activity designed to develop their critical thinking: The "critical card" tool.

    Science.gov (United States)

    Urcola-Pardo, Fernando; Blázquez-Ornat, Isabel; Anguas-Gracia, Ana; Gasch-Gallen, Ángel; Germán-Bes, Concepción

    2018-03-01

    Critical thinking in Health Sciences is among the transversal competences in the Nursing Degree. The critical card is a tool of individual learning, designed to develop critical thinking, and set in the process of environmental health learning. Every student must perform the activity to obtain the highest qualification in Community Health Nursing subject. The aim of this project was to evaluate this learning tool using the students' perceptions after its performance. The evaluation was based on the answers to a questionnaire obtained from the third course students of Nursing Degree at the University of Zaragoza. The questionnaire was made up of 14 Likert-type questions, grouped in four dimensions. The student participation rate was higher than 50%. The analysis of the questionnaire obtained 67,8% positive answers. The variability between dimensions ranged between 49% of positive answers for application in other subjects and 87% of positive answers for the improvements applicable to the instrument. The students coincided in indicating that the critical card is a useful learning tool and could be applicable in other subjects. However, the weight it is given in the global evaluation of the subject is considered to be too low, considering the time used to complete the activity. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Performance modeling in critical engineering systems using RAM analysis

    International Nuclear Information System (INIS)

    Sharma, Rajiv Kumar; Kumar, Sunand

    2008-01-01

    Reliability, availability and maintainability (RAM) analysis of system is helpful in carrying out design modifications, if any, required to achieve minimum failures or to increase mean time between failures (MTBF) and thus to plan maintainability requirements, optimize reliability and maximize equipment availability. To this effect, the paper presents the application of RAM analysis in a process industry. Markovian approach is used to model the system behavior. For carrying out analysis, transition diagrams for various subsystems are drawn and differential equations associated with them are formulated. After obtaining the steady state solution the corresponding values of reliability and maintainability are estimated at different mission times. The computed results are presented to plant personnel for their active consideration. The results proved helpful to them for analyzing the system behavior and thereby to improve the system performance considerably by adopting and practicing suitable maintenance policies/strategies

  7. Critical node treatment in the analytic function expansion method for Pin Power Reconstruction

    International Nuclear Information System (INIS)

    Gao, Z.; Xu, Y.; Downar, T.

    2013-01-01

    Pin Power Reconstruction (PPR) was implemented in PARCS using the eight term analytic function expansion method (AFEN). This method has been demonstrated to be both accurate and efficient. However, similar to all the methods involving analytic functions, such as the analytic node method (ANM) and AFEN for nodal solution, the use of AFEN for PPR also has potential numerical issue with critical nodes. The conventional analytic functions are trigonometric or hyperbolic sine or cosine functions with an angular frequency proportional to buckling. For a critic al node the buckling is zero and the sine functions becomes zero, and the cosine function become unity. In this case, the eight terms of the analytic functions are no longer distinguishable from ea ch other which makes their corresponding coefficients can no longer be determined uniquely. The mode flux distribution of critical node can be linear while the conventional analytic functions can only express a uniform distribution. If there is critical or near critical node in a plane, the reconstructed pin power distribution is often be shown negative or very large values using the conventional method. In this paper, we propose a new method to avoid the numerical problem wit h critical nodes which uses modified trigonometric or hyperbolic sine functions which are the ratio of trigonometric or hyperbolic sine and its angular frequency. If there are no critical or near critical nodes present, the new pin power reconstruction method with modified analytic functions are equivalent to the conventional analytic functions. The new method is demonstrated using the L336C5 benchmark problem. (authors)

  8. Critical node treatment in the analytic function expansion method for Pin Power Reconstruction

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Z. [Rice University, MS 318, 6100 Main Street, Houston, TX 77005 (United States); Xu, Y. [Argonne National Laboratory, 9700 South Case Ave., Argonne, IL 60439 (United States); Downar, T. [Department of Nuclear Engineering, University of Michigan, 2355 Bonisteel blvd., Ann Arbor, MI 48109 (United States)

    2013-07-01

    Pin Power Reconstruction (PPR) was implemented in PARCS using the eight term analytic function expansion method (AFEN). This method has been demonstrated to be both accurate and efficient. However, similar to all the methods involving analytic functions, such as the analytic node method (ANM) and AFEN for nodal solution, the use of AFEN for PPR also has potential numerical issue with critical nodes. The conventional analytic functions are trigonometric or hyperbolic sine or cosine functions with an angular frequency proportional to buckling. For a critic al node the buckling is zero and the sine functions becomes zero, and the cosine function become unity. In this case, the eight terms of the analytic functions are no longer distinguishable from ea ch other which makes their corresponding coefficients can no longer be determined uniquely. The mode flux distribution of critical node can be linear while the conventional analytic functions can only express a uniform distribution. If there is critical or near critical node in a plane, the reconstructed pin power distribution is often be shown negative or very large values using the conventional method. In this paper, we propose a new method to avoid the numerical problem wit h critical nodes which uses modified trigonometric or hyperbolic sine functions which are the ratio of trigonometric or hyperbolic sine and its angular frequency. If there are no critical or near critical nodes present, the new pin power reconstruction method with modified analytic functions are equivalent to the conventional analytic functions. The new method is demonstrated using the L336C5 benchmark problem. (authors)

  9. Dry critical experiments and analyses performed in support of the TOPAZ-2 safety program

    International Nuclear Information System (INIS)

    Pelowitz, D.B.; Sapir, J.; Glushkov, E.S.; Ponomarev-Stepnoi, N.N.; Bubelev, V.G.; Kompanietz, G.B.; Krutov, A.M.; Polyakov, D.N.; Lobynstev, V.A.

    1995-01-01

    In December 1991, the Strategic Defense Initiative Organization decided to investigate the possibility of launching a Russian Topaz-2 space nuclear power system. Functional safety requirements developed for the Topaz mission mandated that the reactor remain subcritical when flooded and immersed in water. Initial experiments and analyses performed in Russia and the United States indicated that the reactor could potentially become supercritical in several water- or sand-immersion scenarios. Consequently, a series of critical experiments was performed on the Narciss M-II facility at the Kurchatov Institute to measure the reactivity effects of water and sand immersion, to quantify the effectiveness of reactor modifications proposed to preclude criticality, and to benchmark the calculational methods and nuclear data used in the Topaz-2 safety analyses. In this paper we describe the Narciss M-II experimental configurations along with the associated calculational models and methods. We also present and compare the measured and calculated results for the dry experimental configurations. copyright 1995 American Institute of Physics

  10. Levels of Management Commitment: A Moderator the Structural Relationships among Critical Success Factors of TQM, World-Class Performance in Operations, and Company Financial Performance

    Directory of Open Access Journals (Sweden)

    Wakhid Slamet Ciptono

    2012-01-01

    Full Text Available This study investigates the moderating impacts of the three levels of management commitment (top, middle, and low levels on the structural relationships among the constructs— six critical success factors of TQM (quality improvement program, supervisory leadership, supplier involvement, management commitment, training to improve products/services, cross-functional relationships; world-class performance in operations (world-class company practices, operational excellence practices, company non-financial performance; and company financial performance. It uses a sample of 1,332 managers in 140 strategic business units (SBUs within 49 oil and gas companies in Indonesia. The empirical results indicate that the goodness-of-fit of the unconstrained model is much better than that of the constrained model, and this is an indicative that the three level of management moderates the structural relationships among the constructs. Those are, three levels of management act as a moderator variable between critical success factors of TQM, world-class company practices, operational excellence practices, company non-financial performance, and company financial performance. Results further reveal that world-class performances in operations (world-class company practices, operational excellence practices, and company non-financial performance were positively mediated the impact of critical success factors of TQM on company financial performance. Results also point out that five of six critical success factors of TQM positively associated with world-class company practices and operational excellence practices under the three levels of management (top, middle, low. World-class company practices and operational excellence practices have direct and significant effects on company non-financial performance (productivity, operational reliability. Furthermore, empirical results suggest that there is a positive and significant relationship between company non

  11. Plant Mediator complex and its critical functions in transcription regulation.

    Science.gov (United States)

    Yang, Yan; Li, Ling; Qu, Li-Jia

    2016-02-01

    The Mediator complex is an important component of the eukaryotic transcriptional machinery. As an essential link between transcription factors and RNA polymerase II, the Mediator complex transduces diverse signals to genes involved in different pathways. The plant Mediator complex was recently purified and comprises conserved and specific subunits. It functions in concert with transcription factors to modulate various responses. In this review, we summarize the recent advances in understanding the plant Mediator complex and its diverse roles in plant growth, development, defense, non-coding RNA production, response to abiotic stresses, flowering, genomic stability and metabolic homeostasis. In addition, the transcription factors interacting with the Mediator complex are also highlighted. © 2015 Institute of Botany, Chinese Academy of Sciences.

  12. Neutron importance and the generalized Green function for the conventionally critical reactor with normalized neutron distribution

    International Nuclear Information System (INIS)

    Khromov, V.V.

    1978-01-01

    The notion of neutron importance when applied to nuclear reactor statics problems described by time-independent homogeneous equations of neutron transport with provision for normalization of neutron distribution is considered. An equation has been obtained for the function of neutron importance in a conditionally critical reactor with respect to an arbitrary nons linear functional determined for the normalized neutron distribution. Relation between this function and the generalized Green function of the selfconjugated operator of the reactor equation is determined and the formula of small perturbations for the functionals of a conditionally critical reactor is deduced

  13. The Efficacy of a Restart Break for Recycling with Optimal Performance Depends Critically on Circadian Timing

    Science.gov (United States)

    Van Dongen, Hans P.A.; Belenky, Gregory; Vila, Bryan J.

    2011-01-01

    Objectives: Under simulated shift-work conditions, we investigated the efficacy of a restart break for maintaining neurobehavioral functioning across consecutive duty cycles, as a function of the circadian timing of the duty periods. Design: As part of a 14-day experiment, subjects underwent two cycles of five simulated daytime or nighttime duty days, separated by a 34-hour restart break. Cognitive functioning and high-fidelity driving simulator performance were tested 4 times per day during the two duty cycles. Lapses on a psychomotor vigilance test (PVT) served as the primary outcome variable. Selected sleep periods were recorded polysomnographically. Setting: The experiment was conducted under standardized, controlled laboratory conditions with continuous monitoring. Participants: Twenty-seven healthy adults (13 men, 14 women; aged 22–39 years) participated in the study. Interventions: Subjects were randomly assigned to a nighttime duty (experimental) condition or a daytime duty (control) condition. The efficacy of the 34-hour restart break for maintaining neurobehavioral functioning from the pre-restart duty cycle to the post-restart duty cycle was compared between these two conditions. Results: Relative to the daytime duty condition, the nighttime duty condition was associated with reduced amounts of sleep, whereas sleep latencies were shortened and slow-wave sleep appeared to be conserved. Neurobehavioral performance measures ranging from lapses of attention on the PVT to calculated fuel consumption on the driving simulators remained optimal across time of day in the daytime duty schedule, but degraded across time of night in the nighttime duty schedule. The 34-hour restart break was efficacious for maintaining PVT performance and other objective neurobehavioral functioning profiles from one duty cycle to the next in the daytime duty condition, but not in the nighttime duty condition. Subjective sleepiness did not reliably track objective neurobehavioral

  14. Selectionist and evolutionary approaches to brain function: a critical appraisal

    Directory of Open Access Journals (Sweden)

    Chrisantha Thomas Fernando

    2012-04-01

    Full Text Available We consider approaches to brain dynamics and function that have been claimed to be Darwinian. These include Edelman’s theory of neuronal group selection, Changeux’s theory of synaptic selection and selective stabilization of pre-representations, Seung’s Darwinian synapse, Loewenstein’s synaptic melioration, Adam’s selfish synapse and Calvin’s replicating activity patterns. Except for the last two, the proposed mechanisms are selectionist but not truly Darwinian, because no replicators with information transfer to copies and hereditary variation can be identified in them. All of them fit, however, a generalized selectionist framework conforming to the picture of Price’s covariance formulation, which deliberately was not specific even to selection in biology, and therefore does not imply an algorithmic picture of biological evolution. Bayesian models and reinforcement learning are formally in agreement with selection dynamics. A classification of search algorithms is shown to include Darwinian replicators (evolutionary units with multiplication, heredity and variability as the most powerful mechanism in a sparsely occupied search space. Examples of why parallel competitive search with information transfer among the units is efficient are given. Finally, we review our recent attempts to construct and analyze simple models of true Darwinian evolutionary units in the brain in terms of connectivity and activity copying of neuronal groups. Although none of the proposed neuronal replicators include miraculous mechanisms, their identification remains a challenge but also a great promise.

  15. Critical adsorption profiles around a sphere and a cylinder in a fluid at criticality: Local functional theory

    Science.gov (United States)

    Yabunaka, Shunsuke; Onuki, Akira

    2017-09-01

    We study universal critical adsorption on a solid sphere and a solid cylinder in a fluid at bulk criticality, where preferential adsorption occurs. We use a local functional theory proposed by Fisher et al. [M. E. Fisher and P. G. de Gennes, C. R. Acad. Sci. Paris Ser. B 287, 207 (1978); M. E. Fisher and H. Au-Yang, Physica A 101, 255 (1980), 10.1016/0378-4371(80)90112-0]. We calculate the mean order parameter profile ψ (r ) , where r is the distance from the sphere center and the cylinder axis, respectively. The resultant differential equation for ψ (r ) is solved exactly around a sphere and numerically around a cylinder. A strong adsorption regime is realized except for very small surface field h1, where the surface order parameter ψ (a ) is determined by h1 and is independent of the radius a . If r considerably exceeds a , ψ (r ) decays as r-(1 +η ) for a sphere and r-(1 +η )/2 for a cylinder in three dimensions, where η is the critical exponent in the order parameter correlation at bulk criticality.

  16. Hydrologic Synthesis Across the Critical Zone Observatory Network: A Step Towards Understanding the Coevolution of Critical Zone Function and Structure

    Science.gov (United States)

    Wlostowski, A. N.; Harman, C. J.; Molotch, N. P.

    2017-12-01

    The physical and biological architecture of the Earth's Critical Zone controls hydrologic partitioning, storage, and chemical evolution of precipitated water. The Critical Zone Observatory (CZO) Network provides an ideal platform to explore linkages between catchment structure and hydrologic function across a gradient of geologic and climatic settings. A legacy of hypothesis-motivated research at each site has generated a wealth of data characterizing the architecture and hydrologic function of the critical zone. We will present a synthesis of this data that aims to elucidate and explain (in the sense of making mutually intelligible) variations in hydrologic function across the CZO network. Top-down quantitative signatures of the storage and partitioning of water at catchment scales extracted from precipitation, streamflow, and meteorological data will be compared with each other, and provide quantitative benchmarks to assess differences in perceptual models of hydrologic function at each CZO site. Annual water balance analyses show that CZO sites span a wide gradient of aridity and evaporative partitioning. The aridity index (PET/P) ranges from 0.3 at Luquillo to 4.3 at Reynolds Creek, while the evaporative index (E/P) ranges from 0.3 at Luquillo (Rio Mamayes) to 0.9 at Reynolds Creek (Reynolds Creek Outlet). Snow depth and SWE observations reveal that snowpack is an important seasonal storage reservoir at three sites: Boulder, Jemez, Reynolds Creek and Southern Sierra. Simple dynamical models are also used to infer seasonal patterns of subsurface catchment storage. A root-zone water balance model reveals unique seasonal variations in plant-available water storage. Seasonal patterns of plant-available storage are driven by the asynchronicity of seasonal precipitation and evaporation cycles. Catchment sensitivity functions are derived at each site to infer relative changes in hydraulic storage (the apparent storage reservoir responsible for modulating streamflow

  17. The effect of criticism on functional brain connectivity and associations with neuroticism.

    Directory of Open Access Journals (Sweden)

    Michelle Nadine Servaas

    Full Text Available Neuroticism is a robust personality trait that constitutes a risk factor for psychopathology, especially anxiety disorders and depression. High neurotic individuals tend to be more self-critical and are overly sensitive to criticism by others. Hence, we used a novel resting-state paradigm to investigate the effect of criticism on functional brain connectivity and associations with neuroticism. Forty-eight participants completed the NEO Personality Inventory Revised (NEO-PI-R to assess neuroticism. Next, we recorded resting state functional magnetic resonance imaging (rsfMRI during two sessions. We manipulated the second session before scanning by presenting three standardized critical remarks through headphones, in which the subject was urged to please lie still in the scanner. A seed-based functional connectivity method and subsequent clustering were used to analyse the resting state data. Based on the reviewed literature related to criticism, we selected brain regions associated with self-reflective processing and stress-regulation as regions of interest. The findings showed enhanced functional connectivity between the clustered seed regions and brain areas involved in emotion processing and social cognition during the processing of criticism. Concurrently, functional connectivity was reduced between these clusters and brain structures related to the default mode network and higher-order cognitive control. Furthermore, individuals scoring higher on neuroticism showed altered functional connectivity between the clustered seed regions and brain areas involved in the appraisal, expression and regulation of negative emotions. These results may suggest that the criticized person is attempting to understand the beliefs, perceptions and feelings of the critic in order to facilitate flexible and adaptive social behavior. Furthermore, multiple aspects of emotion processing were found to be affected in individuals scoring higher on neuroticism during

  18. Defining the Physiological Factors that Contribute to Postflight Changes in Functional Performance

    Science.gov (United States)

    Bloomberg, J. J.; Arzeno, N.; Buxton, R.; Feiveson, A. H.; Kofman, I.; Lawrence, E.; Lee, S. M. C.; Mulavara, A. P.; Peters, B. T.; Platts, S. H.; hide

    2009-01-01

    Astronauts experience alterations in multiple physiological systems due to exposure to the microgravity conditions of space flight. These physiological changes include sensorimotor disturbances, cardiovascular deconditioning and loss of muscle mass and strength. These changes might affect the ability of crewmembers to perform critical mission tasks immediately after landing on lunar and Martian surfaces. To date, changes in functional performance have not been systematically studied or correlated with physiological changes. To understand how changes in physiological function impact functional performance an interdisciplinary pre/postflight testing regimen (Functional Task Test, FTT) has been developed that systematically evaluates both astronaut postflight functional performance and related physiological changes. The overall objective of the FTT is to identify the key underlying physiological factors that contribute to performance of functional tests that are representative of critical mission tasks. This study will identify which physiological systems contribute the most to impaired performance on each functional test. This will allow us to identify the physiological systems that play the largest role in decrement in functional performance. Using this information we can then design and implement countermeasures that specifically target the physiological systems most responsible for the altered functional performance associated with space flight. The functional test battery was designed to address high priority tasks identified by the Constellation program as critical for mission success. The set of functional tests making up the FTT include the: 1) Seat Egress and Walk Test, 2) Ladder Climb Test, 3) Recovery from Fall/Stand Test, 4) Rock Translation Test, 5) Jump Down Test, 6) Torque Generation Test, and 7) Construction Activity Board Test. Corresponding physiological measures include assessments of postural and gait control, dynamic visual acuity, fine motor

  19. Application Of Quality Function Deployment (QFD) To Measure Performance

    International Nuclear Information System (INIS)

    Fazila Said; Mohd Amirul Shafiq Shafiee; Nurul Hasanah Mohd Abd Basir

    2014-01-01

    This study aims to measure service quality performance and identify critical service quality characteristics as perceived by the customers. An integrated results survey that conducted by seven service centers that certified with Quality Management System (QMS) in Nuclear Malaysia are analysed. This is followed by constructing House of Quality (HoQ) and identifying other parameters for the Quality Function Deployment (QFD) matrix. HoQ is a simple and attractive service innovation tool which can be used to directly show comprehensive information which contained the voice of customer (VOC), technical response, technical correlation and matrix relationship. This study revealed that the information's from HoQ with further discussion on planning part which can be used to assist management in knowing the overall detail information of service center achievement and recognizes the solution for unsatisfied customer through priority improvement activity to enhance the customer satisfaction in future. (author)

  20. Functional, interactive and critical health literacy: Varying relationships with control over care and number of GP visits.

    Science.gov (United States)

    van der Heide, Iris; Heijmans, Monique; Schuit, A Jantine; Uiters, Ellen; Rademakers, Jany

    2015-08-01

    The aim of this study is to examine the extent to which functional, interactive and critical health literacy are associated with patients' perceived control over care and frequency of GP visits. Data from the Dutch 'National Panel of People with Chronic Illness or Disability' was used (N=2508). Health literacy was assessed by the Functional, Communicative and Critical Health Literacy measure. Perceived control over care was indicated by perceived ability to organize care, interact with providers and to perform self-care. By multivariate linear and logistic regression analyses, associations between health literacy and perceived control over care and subsequently frequency of GP visits were studied. Mainly interactive health literacy was associated with patients' perceived ability to organize care, interact with healthcare providers and perform self-care, whereas only functional health literacy was associated with number of GP visits. The results imply that some patients' may be less able to exert control over their care because of lower health literacy. Functional, interactive and critical health literacy vary in their relevance for patients' ability to exert control. Initiatives for strengthening patients' role in healthcare may be improved by paying attention to patients' health literacy, specifically functional and interactive health literacy. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  1. Casimir amplitudes and capillary condensation of near-critical fluids between parallel plates: renormalized local functional theory.

    Science.gov (United States)

    Okamoto, Ryuichi; Onuki, Akira

    2012-03-21

    We investigate the critical behavior of a near-critical fluid confined between two parallel plates in contact with a reservoir by calculating the order parameter profile and the Casimir amplitudes (for the force density and for the grand potential). Our results are applicable to one-component fluids and binary mixtures. We assume that the walls absorb one of the fluid components selectively for binary mixtures. We propose a renormalized local functional theory accounting for the fluctuation effects. Analysis is performed in the plane of the temperature T and the order parameter in the reservoir ψ(∞). Our theory is universal if the physical quantities are scaled appropriately. If the component favored by the walls is slightly poor in the reservoir, there appears a line of first-order phase transition of capillary condensation outside the bulk coexistence curve. The excess adsorption changes discontinuously between condensed and noncondensed states at the transition. With increasing T, the transition line ends at a capillary critical point T=T(c) (ca) slightly lower than the bulk critical temperature T(c) for the upper critical solution temperature. The Casimir amplitudes are larger than their critical point values by 10-100 times at off-critical compositions near the capillary condensation line. © 2012 American Institute of Physics

  2. Levels of Management Commitment: a Moderator the Structural Relationships Among Critical Success Factors of TQM, World-Class Performance in Operations, and Company Financial Performance

    OpenAIRE

    Slamet Ciptono, Wakhid

    2008-01-01

    This study investigates the moderating impacts of the three levels of management commitment (top, middle, and low levels) on the structural relationships among the constructs— six critical success factors of TQM (quality improvement program, supervisory leadership, supplier involvement, management commitment, training to improve products/services, cross-functional relationships); world-class performance in operations (world-class company practices, operational excellence practices, company no...

  3. Counter terrorism functions to enhance critical infrastructure resilience against CBRNe terrorism

    NARCIS (Netherlands)

    Bonsen, I.M.; Gaasbeek, R.C.

    2009-01-01

    Current approaches in critical infrastructure protection use long lists of items that fail to give its user a structured answer to the state of protection of its object. The functionality approach uses different terrorist functions to structure the threat (which are to have intent, to scout, to

  4. Effects of exercise training on performance and function in ...

    African Journals Online (AJOL)

    Effects of exercise training on performance and function in individuals with cerebral palsy: ... performance capabilities, and the effect of exercise training interventions, ... The physiology underlying the functional and physical impairments in CP ...

  5. Learning to improve: using writing to increase critical thinking performance in general education biology.

    Science.gov (United States)

    Quitadamo, Ian J; Kurtz, Martha J

    2007-01-01

    Increasingly, national stakeholders express concern that U.S. college graduates cannot adequately solve problems and think critically. As a set of cognitive abilities, critical thinking skills provide students with tangible academic, personal, and professional benefits that may ultimately address these concerns. As an instructional method, writing has long been perceived as a way to improve critical thinking. In the current study, the researchers compared critical thinking performance of students who experienced a laboratory writing treatment with those who experienced traditional quiz-based laboratory in a general education biology course. The effects of writing were determined within the context of multiple covariables. Results indicated that the writing group significantly improved critical thinking skills whereas the non-writing group did not. Specifically, analysis and inference skills increased significantly in the writing group but not the non-writing group. Writing students also showed greater gains in evaluation skills; however, these were not significant. In addition to writing, prior critical thinking skill and instructor significantly affected critical thinking performance, whereas other covariables such as gender, ethnicity, and age were not significant. With improved critical thinking skill, general education biology students will be better prepared to solve problems as engaged and productive citizens.

  6. Critical success factors for TQM implementation and their impact on performance of SMEs

    OpenAIRE

    Salaheldin, S.I.

    2009-01-01

    Abstract: Purpose – The purpose of this paper is to identify the critical success factors of TQM implementation, to evaluate their impact on the primary measures as expressed by the operational performance and the secondary measures as expressed by the organizational performance, and to find out the effect of the operational performance on the organizational performance of small and medium-sized enterprises (SMEs) in the Qatari industrial sector using the structured equation modeling (SEM) ap...

  7. The role of critical thinking skills and learning styles of university students in their academic performance

    Science.gov (United States)

    GHAZIVAKILI, ZOHRE; NOROUZI NIA, ROOHANGIZ; PANAHI, FARIDE; KARIMI, MEHRDAD; GHOLSORKHI, HAYEDE; AHMADI, ZARRIN

    2014-01-01

    Introduction: The Current world needs people who have a lot of different abilities such as cognition and application of different ways of thinking, research, problem solving, critical thinking skills and creativity. In addition to critical thinking, learning styles is another key factor which has an essential role in the process of problem solving. This study aimed to determine the relationship between learning styles and critical thinking of students and their academic performance in Alborz University of Medical Science. Methods: This cross-correlation study was performed in 2012, on 216 students of Alborz University who were selected randomly by the stratified random sampling. The data was obtained via a three-part questionnaire included demographic data, Kolb standardized questionnaire of learning style and California critical thinking standardized questionnaire. The academic performance of the students was extracted by the school records. The validity of the instruments was determined in terms of content validity, and the reliability was gained through internal consistency methods. Cronbach's alpha coefficient was found to be 0.78 for the California critical thinking questionnaire. The Chi Square test, Independent t-test, one way ANOVA and Pearson correlation test were used to determine relationship between variables. The Package SPSS14 statistical software was used to analyze data with a significant level of pcritical thinking of the students showed that the mean of deductive reasoning and evaluation skills were higher than that of other skills and analytical skills had the lowest mean and there was a positive significant relationship between the students’ performance with inferential skill and the total score of critical thinking skills (pcritical thinking had significant difference between different learning styles. Conclusion: The results of this study showed that the learning styles, critical thinking and academic performance are significantly associated

  8. A study of critical reasoning in online learning: application of the Occupational Performance Process Model.

    Science.gov (United States)

    Mitchell, Anita Witt; Batorski, Rosemary E

    2009-01-01

    This study examined the effect of an online guided independent study on critical reasoning skills. Twenty-one first-semester Master of Occupational Therapy students completed an online assignment designed to facilitate application of the Occupational Performance Process Model (Fearing & Clark) and kept reflective journals. Data from the journals were analyzed in relation to the three sets of questions, question type and results of the Watson-Glaser Critical Thinking Appraisal (WGCTA). This assignment appeared to be effective for enhancing awareness and use of critical reasoning skills. Differences in patterns of critical reasoning between students with high and low WGCTA scores and results of an inductive analysis of the journal entries are discussed. Future research investigating the types of feedback that effectively facilitate development of critical reasoning and whether students with high and low WGCTA scores might benefit from different types of instruction and/or feedback is recommended. Copyright (c) 2009 John Wiley & Sons, Ltd.

  9. Conformal scalar field on the hyperelliptic curve and critical Ashkin-Teller multipoint correlation functions

    International Nuclear Information System (INIS)

    Zamolodchikov, A.B.

    1987-01-01

    A multipoint conformal block of Ramond states of the two-dimensional free scalar field is calculated. This function is related to the free energy of the scalar field on the hyperelliptic Riemann surface under a particular choice of boundary conditions. Being compactified on the circle this field leads to the crossing symmetric correlation functions with a discrete spectrum of scale dimensions. These functions are supposed to describe multipoint spin correlations of the critical Ashkin-Teller model. (orig.)

  10. Critical appraisal of questionnaires to assess functional impairment in individuals with mild cognitive impairment.

    Science.gov (United States)

    Kaur, Navaldeep; Belchior, Patricia; Gelinas, Isabelle; Bier, Nathalie

    2016-09-01

    Mild deficits in instrumental activities of daily living (IADLs) have consistently been reported in the individuals with mild cognitive impairment (MCI). A variety of functional assessment tools, including self-and informant report questionnaires and performance-based measures, have been employed in MCI. Previously, a limited focus has been directed at appraising the quality of questionnaires. The goal of this study was to identify the questionnaires that have been validated in the MCI population. Additionally, the quality of validation studies and psychometric attributes of these questionnaires were appraised. Relevant articles were systematically searched in PsychINFO, Ovid MEDLINE, and CINAHL against specific eligibility criteria. To evaluate the methodology of the psychometric studies, the COSMIN checklist was employed. Also, the psychometric properties of the assessment tools were evaluated based upon Terwee's criteria. A total of five psychometric studies and questionnaires were critically evaluated. Varying psychometric properties were available for the chosen tools. None of the studies received the best possible rating for their methodological quality. It was found that questionnaires with high discriminative ability to distinguish MCI from other diagnostic groups were: Disability Assessment in Dementia-6 (DAD-6), Functional Activity Questionnaire (FAQ), and Alzheimer's Disease Cooperative Study/Activities of Daily Living scale adapted for MCI patients (ADCS-MCI-ADL-24). Psychometric studies with strong methodological rigor are required in the future. Considering the fact that IADL decline has been associated with dementia, early detection of functional difficulties in MCI needs to be encouraged as it will allow suitable and timely interventions to prolong functional independence of affected individuals.

  11. Functional Imaging of the Foot with Perfusion Angiography in Critical Limb Ischemia

    Energy Technology Data Exchange (ETDEWEB)

    Reekers, Jim A., E-mail: j.a.reekers@amc.uva.nl [AMC, Dept of Radiology (Netherlands); Koelemay, Mark J. W., E-mail: m.j.koelemaij@amc.uva.nl [AMC, Dept of Vascular Surgery (Netherlands); Marquering, Henk A., E-mail: h.a.marquering@amc.uva.nl; Bavel, Ed T. van, E-mail: e.vanbavel@amc.uva.n [AMC, Dept of Biomedical Engineering and Physics (Netherlands)

    2016-02-15

    PurposeTo report on the first clinical experience with perfusion angiography (PA) of the foot in patients with chronic critical limb ischemia.Materials and MethodsPA is a post-processing software algorithm and no extra digital subtraction angiography (DSA) has to be performed for this analysis. The data used to test the feasibility of PA were obtained from a consecutive group of 89 patients with CLI who were treated with standard below the knee angioplasty and 12 separate patients who were not suitable for endovascular revascularization.ResultsMotion artifacts in the dataset of the DSA made post-procedural analysis impossible in 10 % intervention. In the majority of patients (59/68) PA showed an increase in volume flow in the foot after successful angioplasty of the crural vessels. However, in 9/68 patients no increase was seen after successful angioplasty. With the use of a local administered competitive α-adrenergic receptor antagonist, it is also possible to test and quantify the capillary resistance index which is a parameter for the remaining functionality of the microcirculation in CLI patients.ConclusionPA might be used as a new endpoint for lower limb revascularization and can also be used to test the functionality the microcirculation to identify sub-types of patients with CLI. Clinical evaluation and standardization of PA is mandatory before introduction in daily practice.

  12. Quantitative research on critical thinking and predicting nursing students' NCLEX-RN performance.

    Science.gov (United States)

    Romeo, Elizabeth M

    2010-07-01

    The concept of critical thinking has been influential in several disciplines. Both education and nursing in general have been attempting to define, teach, and measure this concept for decades. Nurse educators realize that critical thinking is the cornerstone of the objectives and goals for nursing students. The purpose of this article is to review and analyze quantitative research findings relevant to the measurement of critical thinking abilities and skills in undergraduate nursing students and the usefulness of critical thinking as a predictor of National Council Licensure Examination-Registered Nurse (NCLEX-RN) performance. The specific issues that this integrative review examined include assessment and analysis of the theoretical and operational definitions of critical thinking, theoretical frameworks used to guide the studies, instruments used to evaluate critical thinking skills and abilities, and the role of critical thinking as a predictor of NCLEX-RN outcomes. A list of key assumptions related to critical thinking was formulated. The limitations and gaps in the literature were identified, as well as the types of future research needed in this arena. Copyright 2010, SLACK Incorporated.

  13. Modelling of critical functions of nuclear reactors using Fild Programmable Gate Array

    International Nuclear Information System (INIS)

    Teixeira, Pamela Iara Nolasco

    2016-01-01

    This paper proposes the development of a method using FPGA for critical security functions of a nuclear reactor. It was implemented two critical safety functions in VHDL, which is a way to describe, through a program, the behavior of a circuit or digital component. Two critical security functions, FCS Core Cooling, responsible for cooling the reactor core in the charts of the plant and also in the event of accidents involving loss of coolant and FCS Heat Transfer, responsible for cooling the reactor core in the event an accident with loss of coolant were implemented. In this Dissertation it was chosen the use of FPGA, because - due to the effects of aging, obsolescence issues, environmental degradation and mechanical failures - nuclear power plants need to replace their older systems by new ones based on digital technology. The technologies obtained using a system described in hardware language can be implemented in a programmable device, having the advantage of changing the code at any time. (author)

  14. Two-Phase Iteration for Value Function Approximation and Hyperparameter Optimization in Gaussian-Kernel-Based Adaptive Critic Design

    Directory of Open Access Journals (Sweden)

    Xin Chen

    2015-01-01

    Full Text Available Adaptive Dynamic Programming (ADP with critic-actor architecture is an effective way to perform online learning control. To avoid the subjectivity in the design of a neural network that serves as a critic network, kernel-based adaptive critic design (ACD was developed recently. There are two essential issues for a static kernel-based model: how to determine proper hyperparameters in advance and how to select right samples to describe the value function. They all rely on the assessment of sample values. Based on the theoretical analysis, this paper presents a two-phase simultaneous learning method for a Gaussian-kernel-based critic network. It is able to estimate the values of samples without infinitively revisiting them. And the hyperparameters of the kernel model are optimized simultaneously. Based on the estimated sample values, the sample set can be refined by adding alternatives or deleting redundances. Combining this critic design with actor network, we present a Gaussian-kernel-based Adaptive Dynamic Programming (GK-ADP approach. Simulations are used to verify its feasibility, particularly the necessity of two-phase learning, the convergence characteristics, and the improvement of the system performance by using a varying sample set.

  15. THE PERFORMANT FUNCTION AND THE REFERENTIAL FUNCTION IN THEATRE

    Directory of Open Access Journals (Sweden)

    Raluca GHERVAN

    2014-11-01

    Full Text Available Pour illustrer la dynamique et l’alternance entre la fonction performative et la fonction référentielle dans le théâtre, il faut réaliser une analyse d’autres deux domaines, ayant des ressemblances de point de vue de la même alternance, le sport de performance et le spectacle de cirque. Tout en investiguant le besoin humain d’être témoin aux spectacles publics, on peut comprendre mieux sa façon de diviser l’attention entre ce que détient, dans un spectacle, une fonction performative et une fonction référentielle. Le poids de cette alternance dépend de la modalité de réaliser son double rôle de producteur de signe et du signe en soi.

  16. The role of critical thinking skills and learning styles of university students in their academic performance

    Directory of Open Access Journals (Sweden)

    ZOHRE GHAZIVAKILI

    2014-07-01

    Full Text Available Introduction: The current world needs people who have a lot of different abilities such as cognition and application of different ways of thinking, research, problem solving, critical thinking skills and creativity. In addition to critical thinking, learning styles is another key factor which has an essential role in the process of problem solving. This study aimed to determine the relationship between learning styles and critical thinking of students and their academic performance in Alborz University of Medical Sciences. Methods: This cross-correlation study was performed in 2012, on 216 students of Alborz University who were selected randomly by the stratified method. The data was obtained via a three-part questionnaire included demographic data, Kolb standardized questionnaire of learning style and California critical thinking standardized questionnaire. The academic performance of the students was extracted by the school records. The validity of the instruments was determined in terms of content validity, and the reliability was gained through internal consistency methods. Cronbach's alpha coefficient was found to be 0.78 for the California critical thinking questionnaire. The Chi Square test, Independent T-test, one way ANOVA and Pearson Correlation test were used to determine relationship between variables. The Package SPSS14 statistical software was used to analyze data with a significant level of p<0.05. Results: Our findings indicated the significant difference of mean score in four learning style, suggesting university students with convergent learning style have better performance than other groups. Also learning style had a relationship with age, gender, field of study, semester and job. The results about the critical thinking of the students showed that the mean of deductive reasoning and evaluation skills were higher than that of other skills and analytical skills had the lowest mean and there was a positive significant

  17. The role of critical thinking skills and learning styles of university students in their academic performance.

    Science.gov (United States)

    Ghazivakili, Zohre; Norouzi Nia, Roohangiz; Panahi, Faride; Karimi, Mehrdad; Gholsorkhi, Hayede; Ahmadi, Zarrin

    2014-07-01

    The Current world needs people who have a lot of different abilities such as cognition and application of different ways of thinking, research, problem solving, critical thinking skills and creativity. In addition to critical thinking, learning styles is another key factor which has an essential role in the process of problem solving. This study aimed to determine the relationship between learning styles and critical thinking of students and their academic performance in Alborz University of Medical Science. This cross-correlation study was performed in 2012, on 216 students of Alborz University who were selected randomly by the stratified random sampling. The data was obtained via a three-part questionnaire included demographic data, Kolb standardized questionnaire of learning style and California critical thinking standardized questionnaire. The academic performance of the students was extracted by the school records. The validity of the instruments was determined in terms of content validity, and the reliability was gained through internal consistency methods. Cronbach's alpha coefficient was found to be 0.78 for the California critical thinking questionnaire. The Chi Square test, Independent t-test, one way ANOVA and Pearson correlation test were used to determine relationship between variables. The Package SPSS14 statistical software was used to analyze data with a significant level of pstudents with convergent learning style have better performance than other groups. Also learning style had a relationship with age, gender, field of study, semester and job. The results about the critical thinking of the students showed that the mean of deductive reasoning and evaluation skills were higher than that of other skills and analytical skills had the lowest mean and there was a positive significant relationship between the students' performance with inferential skill and the total score of critical thinking skills (pskills and deductive reasoning had significant

  18. A strategy for minimizing common mode human error in executing critical functions and tasks

    International Nuclear Information System (INIS)

    Beltracchi, L.; Lindsay, R.W.

    1992-01-01

    Human error in execution of critical functions and tasks can be costly. The Three Mile Island and the Chernobyl Accidents are examples of results from human error in the nuclear industry. There are similar errors that could no doubt be cited from other industries. This paper discusses a strategy to minimize common mode human error in the execution of critical functions and tasks. The strategy consists of the use of human redundancy, and also diversity in human cognitive behavior: skill-, rule-, and knowledge-based behavior. The authors contend that the use of diversity in human cognitive behavior is possible, and it minimizes common mode error

  19. Developing high-performance cross-functional teams: Understanding motivations, functional loyalties, and teaming fundamentals

    Energy Technology Data Exchange (ETDEWEB)

    Miller, M.A.

    1996-08-01

    Teamwork is the key to the future of effective technology management. Today`s technologies and markets have become too complex for individuals to work alone. Global competition, limited resources, cost consciousness, and time pressures have forced organizations and project managers to encourage teamwork. Many of these teams will be cross-functional teams that can draw on a multitude of talents and knowledge. To develop high-performing cross-functional teams, managers must understand motivations, functional loyalties, and the different backgrounds of the individual team members. To develop a better understanding of these issues, managers can learn from experience and from literature on teams and teaming concepts. When studying the literature to learn about cross-functional teaming, managers will find many good theoretical concepts, but when put into practice, these concepts have varying effects. This issue of varying effectiveness is what drives the research for this paper. The teaming concepts were studied to confirm or modify current understanding. The literature was compared with a {open_quotes}ground truth{close_quotes}, a survey of the reality of teaming practices, to examine the teaming concepts that the literature finds to be critical to the success of teams. These results are compared to existing teams to determine if such techniques apply in real-world cases.

  20. Beethoven recordings reviewed: a systematic method for mapping the content of music performance criticism.

    Science.gov (United States)

    Alessandri, Elena; Williamson, Victoria J; Eiholzer, Hubert; Williamon, Aaron

    2015-01-01

    Critical reviews offer rich data that can be used to investigate how musical experiences are conceptualized by expert listeners. However, these data also present significant challenges in terms of organization, analysis, and interpretation. This study presents a new systematic method for examining written responses to music, tested on a substantial corpus of music criticism. One hundred critical reviews of Beethoven's piano sonata recordings, published in the Gramophone between August 1934 and July 2010, were selected using in-depth data reduction (qualitative/quantitative approach). The texts were then examined using thematic analysis in order to generate a visual descriptive model of expert critical review. This model reveals how the concept of evaluation permeates critical review. It also distinguishes between two types of descriptors. The first characterizes the performance in terms of specific actions or features of the musical sound (musical parameters, technique, and energy); the second appeals to higher-order properties (artistic style, character and emotion, musical structure, communicativeness) or assumed performer qualities (understanding, intentionality, spontaneity, sensibility, control, and care). The new model provides a methodological guide and conceptual basis for future studies of critical review in any genre.

  1. [Effect of physical activity on functional performance].

    Science.gov (United States)

    Nikolaus, T

    2001-02-01

    Epidemiological studies clearly show a connection between physical activity and the occurrence of disabilities in old age. Physical exercise is possible and useful at every age. Numerous intervention trials have shown that training of endurance, strength and coordination has positive effects on the cardiovascular system, the lung, the musculo-skeletal system, metabolism and the immune system in elderly people. Even very frail elderly people can increase their muscle strength and functional capabilities by strength training. Group sessions may improve social interactions and additionally increase the quality of life.

  2. Validation of the Dutch functional, communicative and critical health literacy scales

    NARCIS (Netherlands)

    van der Vaart, R.; Drossaert, Constance H.C.; Taal, Erik; ten Klooster, Peter M.; Hilderink-Koertshuis, Rianne T.E.; Klaase, Joost M.; van de Laar, Mart A F J

    2012-01-01

    Objective: While most existing health literacy (HL) measures focus primarily on reading comprehension, the functional, communicative and critical HL scales from Ishikawa et al. [19] aim to measure a broader HL spectrum. The objective of this study was to evaluate the validity of the Dutch

  3. Parents' Criticisms and Attributions about Their Adult Children with High Functioning Autism or Schizophrenia

    Science.gov (United States)

    Wasserman, Stephanie; Weisman de Mamani, Amy; Mundy, Peter

    2010-01-01

    The current study examined the criticism component of expressed emotion (EE) and attributions in parents of adults diagnosed with schizophrenia/schizoaffective disorder (S/SA) or high functioning autism/Asperger's. Consistent with study hypotheses, parents of adults diagnosed with autism/Asperger's disorder exhibited lower levels of high…

  4. Using Digital Comics to Develop Digital Literacy: Fostering Functionally, Critically, and Rhetorically Literate Students

    Science.gov (United States)

    Kirchoff, Jeff

    2017-01-01

    Literacy scholarship has established the importance of teaching, supporting, and facilitating digital literacy education for 21st century students. Stuart Selber goes a step further, arguing that students must be functionally (using digital technology), critically (questioning digital technology), and rhetorically (producing effective digital…

  5. Critical dimension of bosonic string theory and zeta-function regularization

    International Nuclear Information System (INIS)

    Vanzo, L.; Zerbini, S.; Istituto Nazionale di Fisica Nucleare, Povo

    1988-01-01

    A derivation of the critical dimension of the Polyakov bosonic string is presented. It is based on the use of the anholonomic formalism, a ghost-anti-ghost symmetric action, zeta-function regularization and the Seeley method of pseudo-differential operators. (orig.)

  6. Variations in Financial Performance among Peer Groups of Critical Access Hospitals

    Science.gov (United States)

    Pink, George H.; Holmes, George M.; Thompson, Roger E.; Slifkin, Rebecca T.

    2007-01-01

    Context: Among the large number of hospitals with critical access hospital (CAH) designation, there is substantial variation in facility revenue as well as the number and types of services provided. If these variations have material effects on financial indicators, then performance comparisons among all CAHs are problematic. Purpose: To…

  7. Skeletal Muscle Ultrasonography in Nutrition and Functional Outcome Assessment of Critically Ill Children: Experience and Insights From Pediatric Disease and Adult Critical Care Studies [Formula: see text].

    Science.gov (United States)

    Ong, Chengsi; Lee, Jan Hau; Leow, Melvin K S; Puthucheary, Zudin A

    2017-09-01

    Evidence suggests that critically ill children develop muscle wasting, which could affect outcomes. Muscle ultrasound has been used to track muscle wasting and association with outcomes in critically ill adults but not children. This review aims to summarize methodological considerations of muscle ultrasound, structural findings, and possibilities for its application in the assessment of nutrition and functional outcomes in critically ill children. Medline, Embase, and CINAHL databases were searched up until April 2016. Articles describing skeletal muscle ultrasound in children and critically ill adults were analyzed qualitatively for details on techniques and findings. Thickness and cross-sectional area of various upper and lower body muscles have been studied to quantify muscle mass and detect muscle changes. The quadriceps femoris muscle is one of the most commonly measured muscles due to its relation to mobility and is sensitive to changes over time. However, the margin of error for quadriceps thickness is too wide to reliably detect muscle changes in critically ill children. Muscle size and its correlation with strength and function also have not yet been studied in critically ill children. Echogenicity, used to detect compromised muscle structure in neuromuscular disease, may be another property worth studying in critically ill children. Muscle ultrasound may be useful in detecting muscle wasting in critically ill children but has not been shown to be sufficiently reliable in this population. Further study of the reliability and correlation with functional outcomes and nutrition intake is required before muscle ultrasound is routinely employed in critically ill children.

  8. Remote Core Locking: Migrating Critical-Section Execution to Improve the Performance of Multithreaded Applications

    OpenAIRE

    Lozi , Jean-Pierre; David , Florian; Thomas , Gaël; Lawall , Julia; Muller , Gilles

    2014-01-01

    National audience; The scalability of multithreaded applications on current multicore systems is hampered by the performance of lock algorithms, due to the costs of access contention and cache misses. In this paper, we propose a new lock algorithm, Remote Core Locking (RCL), that aims to improve the performance of critical sections in legacy applications on multicore architectures. The idea of RCL is to replace lock acquisitions by optimized remote procedure calls to a dedicated server core. ...

  9. Surface critical behavior and scaling functions for the three-dimensional mean spherical model

    Energy Technology Data Exchange (ETDEWEB)

    Amin, Magdy E. [Mathematics Department, Ar' ar Teacher College, Kingdom of Saudi Arabia (Saudi Arabia) and Mathematics Department, Faculty of Science, Minia University (Egypt)]. E-mail: aminmagdy@yahoo.com

    2006-10-09

    The d-dimensional mean spherical model on a fully finite L{sup d} simple cubic lattice with Neumann-Dirichlet boundary conditions is considered in the presence of a surface external fields acting at the surfaces bounding the system. Exact calculations are evaluated for the fully finite system and in the case of a film geometry Lx{approx}{sup d-1}. Critical finite-size scaling functions both for the specific heat and the mean-square magnetization are derived and investigated close to and below the bulk critical temperature K{sub c}.

  10. Relationship between kinesiophobia and performance in a functional capacity evaluation

    NARCIS (Netherlands)

    Reneman, MF; Jorritsma, W; Dijkstra, SJ; Dijkstra, PU

    2003-01-01

    Fear of movement and (re) injury (kinesiophobia) has been postulated to play an important role in the performance in a Functional Capacity Evaluation (FCE). This study was performed to analyze the relationship between kinesiophobia and performance in an FCE. Kinesiophobia and FCE performance of 54

  11. Using Performance Assessment Model in Physics Laboratory to Increase Students’ Critical Thinking Disposition

    Science.gov (United States)

    Emiliannur, E.; Hamidah, I.; Zainul, A.; Wulan, A. R.

    2017-09-01

    Performance Assessment Model (PAM) has been developed to represent the physics concepts which able to be devided into five experiments: 1) acceleration due to gravity; 2) Hooke’s law; 3) simple harmonic motion; 4) work-energy concepts; and 5) the law of momentum conservation. The aim of this study was to determine the contribution of PAM in physics laboratory to increase students’ Critical Thinking Disposition (CTD) at senior high school. Subject of the study were 11th grade consist 32 students of a senior high school in Lubuk Sikaping, West Sumatera. The research used one group pretest-postest design. Data was collected through essay test and questionnaire about CTD. Data was analyzed using quantitative way with N-gain value. This study concluded that performance assessmet model effectively increases the N-gain at medium category. It means students’ critical thinking disposition significant increase after implementation of performance assessment model in physics laboratory.

  12. [Experts consensus on the management of the right heart function in critically ill patients].

    Science.gov (United States)

    Wang, X T; Liu, D W; Zhang, H M; Long, Y; Guan, X D; Qiu, H B; Yu, K J; Yan, J; Zhao, H; Tang, Y Q; Ding, X; Ma, X C; Du, W; Kang, Y; Tang, B; Ai, Y H; He, H W; Chen, D C; Chen, H; Chai, W Z; Zhou, X; Cui, N; Wang, H; Rui, X; Hu, Z J; Li, J G; Xu, Y; Yang, Y; Ouyan, B; Lin, H Y; Li, Y M; Wan, X Y; Yang, R L; Qin, Y Z; Chao, Y G; Xie, Z Y; Sun, R H; He, Z Y; Wang, D F; Huang, Q Q; Jiang, D P; Cao, X Y; Yu, R G; Wang, X; Chen, X K; Wu, J F; Zhang, L N; Yin, M G; Liu, L X; Li, S W; Chen, Z J; Luo, Z

    2017-12-01

    To establish the experts consensus on the right heart function management in critically ill patients. The panel of consensus was composed of 30 experts in critical care medicine who are all members of Critical Hemodynamic Therapy Collaboration Group (CHTC Group). Each statement was assessed based on the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) principle. Then the Delphi method was adopted by 52 experts to reassess all the statements. (1) Right heart function is prone to be affected in critically illness, which will result in a auto-exaggerated vicious cycle. (2) Right heart function management is a key step of the hemodynamic therapy in critically ill patients. (3) Fluid resuscitation means the process of fluid therapy through rapid adjustment of intravascular volume aiming to improve tissue perfusion. Reversed fluid resuscitation means reducing volume. (4) The right ventricle afterload should be taken into consideration when using stroke volume variation (SVV) or pulse pressure variation (PPV) to assess fluid responsiveness.(5)Volume overload alone could lead to septal displacement and damage the diastolic function of the left ventricle. (6) The Starling curve of the right ventricle is not the same as the one applied to the left ventricle,the judgement of the different states for the right ventricle is the key of volume management. (7) The alteration of right heart function has its own characteristics, volume assessment and adjustment is an important part of the treatment of right ventricular dysfunction (8) Right ventricular enlargement is the prerequisite for increased cardiac output during reversed fluid resuscitation; Nonetheless, right heart enlargement does not mandate reversed fluid resuscitation.(9)Increased pulmonary vascular resistance induced by a variety of factors could affect right heart function by obstructing the blood flow. (10) When pulmonary hypertension was detected in clinical scenario, the differentiation of

  13. Performance study of ejector cooling cycle at critical mode under superheated primary flow

    International Nuclear Information System (INIS)

    Tashtoush, Bourhan; Alshare, Aiman; Al-Rifai, Saja

    2015-01-01

    Highlights: • The ECC is modeled using EES Software and it is validated with published data. • Detailed analysis of the ECC with different refrigerants is conducted. • The constant pressure mixing is better than constant area mixing ejectors. • R134a is the selected refrigerant for the best cooling cycle performance. • The superheated primary flow at critical mode is achieved with EJ2 ejector used. - Abstract: In this work the performance of the ejector cooling cycle is investigated at critical mode, where, the effects of ejector geometry, refrigerant type, and operating condition are studied. The ejector cooling cycle is modeled with EES Software. The mass, momentum, and energy conservation principles are applied to the secondary and primary flows to investigate the performance of the ejector cooling cycle under superheated primary flow. The refrigerant R134 a is selected based on the merit of its environmental and performance characteristics. The primary working fluid in the refrigeration cycle is maintained at superheated conditions for optimal ejector performance. The solar generator temperature ranges are 80–100 °C. The operating temperature of evaporator range is 8–12 °C and the optimal condensation temperature is in the range of 28–40 °C. It is found that constant-pressure mixing ejector generates higher backpressure than constant-area mixing ejector for the same entrainment ratio and COP. The type of ejector is selected based on the performance criteria of the critical backpressure and choking condition of the primary flow, the so called EJ2 type ejector meets the criteria. The COP is found to be in the range of 0.59–0.67 at condenser backpressure of 24 bar due to higher critical condenser pressure and higher generator temperature

  14. Oscillatory Critical Amplitudes in Hierarchical Models and the Harris Function of Branching Processes

    Science.gov (United States)

    Costin, Ovidiu; Giacomin, Giambattista

    2013-02-01

    Oscillatory critical amplitudes have been repeatedly observed in hierarchical models and, in the cases that have been taken into consideration, these oscillations are so small to be hardly detectable. Hierarchical models are tightly related to iteration of maps and, in fact, very similar phenomena have been repeatedly reported in many fields of mathematics, like combinatorial evaluations and discrete branching processes. It is precisely in the context of branching processes with bounded off-spring that T. Harris, in 1948, first set forth the possibility that the logarithm of the moment generating function of the rescaled population size, in the super-critical regime, does not grow near infinity as a power, but it has an oscillatory prefactor (the Harris function). These oscillations have been observed numerically only much later and, while the origin is clearly tied to the discrete character of the iteration, the amplitude size is not so well understood. The purpose of this note is to reconsider the issue for hierarchical models and in what is arguably the most elementary setting—the pinning model—that actually just boils down to iteration of polynomial maps (and, notably, quadratic maps). In this note we show that the oscillatory critical amplitude for pinning models and the Harris function coincide. Moreover we make explicit the link between these oscillatory functions and the geometry of the Julia set of the map, making thus rigorous and quantitative some ideas set forth in Derrida et al. (Commun. Math. Phys. 94:115-132, 1984).

  15. Spectral function and quark diffusion constant in non-critical holographic QCD

    Energy Technology Data Exchange (ETDEWEB)

    Bu Yanyan, E-mail: yybu@itp.ac.cn [Institute of Theoretical Physics, Academia Sinica, Beijing 100190 (China); Yang Jinmin, E-mail: jmyang@itp.ac.cn [Institute of Theoretical Physics, Academia Sinica, Beijing 100190 (China)

    2012-02-11

    Motivated by recent studies of intersecting D-brane systems in critical string theory and phenomenological AdS/QCD models, we present a detailed analysis for the vector and scalar fluctuations in a non-critical holographic QCD model in the high temperature phase, i.e., the chiral symmetric phase. This model is described by N{sub f} pairs of D4 and D4{sup Macron} probe branes in a non-critical AdS{sub 6} black hole background. Focusing on the hydrodynamic as well as the high frequency limit, we analytically obtain spectral functions for vector and scalar modes on the flavor probe. Then we extract the light quark diffusion constant for flavor current using three different methods and find that different methods give the same results. We also compute the heavy quark diffusion constant for comparison with the light quark case.

  16. Empirical evaluation of cell critical volume dose vs. cell response function for pink mutations in tradescantia

    International Nuclear Information System (INIS)

    Varma, M.N.; Bond, V.P.

    1982-01-01

    Microdosimetric spectra for 0.43, 1.8, and 14.7 MeV neutrons, and for 215 kVp x rays and 1250 keV gammas were used in conjunction with relative biological effectiveness (RBE) values for pink mutations in Tradescantia to obtain an effectiveness function (i.e., a cell critical volume dose vs. cell response function). This effectiveness function (or hit size weighting function) provides the probability of inducing a biological effect of interest (in the present study, pink mutations in Tradescantia) as a function of lineal energy density y. In a preliminary analysis the critical value of y above which pink mutations are seen was 4.5 keV/μm, and the value of y at which the probability reaches unity was 115 keV/μm. Idealized but approximate event size distributions for mono-LET particles ranging from 10 to 5000 keV/μm were generated, and these distributions were weighted by the effectiveness function to determine the pink mutation frequencies. Results are compared with measured pink mutation frequencies for 11 keV/μm ( 12 C) and 31 keV/μm ( 20 Ne) ions

  17. Scaling functions for the Inverse Compressibility near the QCD critical point

    Science.gov (United States)

    Lacey, Roy

    2017-09-01

    The QCD phase diagram can be mapped out by studying fluctuations and their response to changes in the temperature and baryon chemical potential. Theoretical studies indicate that the cumulant ratios Cn /Cm used to characterize the fluctuation of conserved charges, provide a valuable probe of deconfinement and chiral dynamics, as well as for identifying the position of the critical endpoint (CEP) in the QCD phase diagram. The ratio C1 /C2 , which is linked to the inverse compressibility, vanishes at the CEP due to the divergence of the net quark number fluctuations at the critical point belonging to the Z(2) universality class. Therefore, it's associated scaling function can give insight on the location of the critical end point, as well as the critical exponents required to assign its static universality class. Scaling functions for the ratio C1 /C2 , obtained from net-proton multiplicity distributions for a broad range of collision centralities in Au+Au (√{sNN} = 7.7 - 200 GeV) collisions will be presented and discussed.

  18. ‘Promising Spaces’: Universities’ Critical-Moral Mission and Educative Function

    Directory of Open Access Journals (Sweden)

    Monica McLean

    2015-12-01

    Full Text Available Attention has been drawn to a hollowing out of universities' purposes to serve economic interests only. This dissatisfaction has provoked thinking about how to reclaim a critical moral role for universties in society. Inspired by contemporary utopian studies the paper brings together traditional ideas about how transmitting university knowledge connects to universities' critical-moral functions; Amartya Sen and Martha Nussbaum's capabilities approach adapted for education; and Bernstein's theories about knowledge distribution. Focusing on the educative function, the aim is to develop a theoretically informed and practical vision of a university education, which is both personally transformative and produces critical citizens and workers. Research evidence from two projects on university education reveals 'promising spaces' (Cooper, 2014. I conclude that there is reason to believe that the transmission and acquisition of knowledge and understanding in specific fields is key to preserving and recreating a critical-moral mission for universities wherever they are in the world, even though current conditions are inclement and unequal.

  19. Critical temperature for shape transition in hot nuclei within covariant density functional theory

    Science.gov (United States)

    Zhang, W.; Niu, Y. F.

    2018-05-01

    Prompted by the simple proportional relation between critical temperature for pairing transition and pairing gap at zero temperature, we investigate the relation between critical temperature for shape transition and ground-state deformation by taking even-even Cm-304286 isotopes as examples. The finite-temperature axially deformed covariant density functional theory with BCS pairing correlation is used. Since the Cm isotopes are the newly proposed nuclei with octupole correlations, we studied in detail the free energy surface, the Nilsson single-particle (s.p.) levels, and the components of s.p. levels near the Fermi level in 292Cm. Through this study, the formation of octupole equilibrium is understood by the contribution coming from the octupole driving pairs with Ω [N ,nz,ml] and Ω [N +1 ,nz±3 ,ml] for single-particle levels near the Fermi surfaces as it provides a good manifestation of the octupole correlation. Furthermore, the systematics of deformations, pairing gaps, and the specific heat as functions of temperature for even-even Cm-304286 isotopes are discussed. Similar to the relation between the critical pairing transition temperature and the pairing gap at zero temperature Tc=0.6 Δ (0 ) , a proportional relation between the critical shape transition temperature and the deformation at zero temperature Tc=6.6 β (0 ) is found for both octupole shape transition and quadrupole shape transition for the isotopes considered.

  20. Renewing functionalized graphene as electrodes for high-performance supercapacitors

    Energy Technology Data Exchange (ETDEWEB)

    Fang, Yan [National Center for Nanoscience and Technology, Zhongguancun, Beiyitiao No.11, Beijing, 100190 (China); Laboratory of Advanced Materials, Department of Materials Science and Engineering, Tsinghua University, Beijing, 100084 (China); Luo, Bin; Jia, Yuying; Li, Xianglong; Wang, Bin; Song, Qi [National Center for Nanoscience and Technology, Zhongguancun, Beiyitiao No.11, Beijing, 100190 (China); Kang, Feiyu [Laboratory of Advanced Materials, Department of Materials Science and Engineering, Tsinghua University, Beijing, 100084 (China); Zhi, Linjie [National Center for Nanoscience and Technology, Zhongguancun, Beiyitiao No.11, Beijing, 100190 (China); School of Materials Science and Engineering, University of Shanghai for Science and Technology, Jungong Road 516, 200093, Shanghai (China)

    2012-12-11

    An acid-assisted ultrarapid thermal strategy is developed for constructing specifically functionalized graphene. The electrochemical performance of functionalized graphene can be boosted via elaborate coupling between the pseudocapacitance and the electronic double layer capacitance through rationally tailoring the structure of graphene sheets. This presents an opportunity for developing further high-performance graphene-based electrodes to bridge the performance gap between traditional capacitors and batteries. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  1. Renewing functionalized graphene as electrodes for high-performance supercapacitors.

    Science.gov (United States)

    Fang, Yan; Luo, Bin; Jia, Yuying; Li, Xianglong; Wang, Bin; Song, Qi; Kang, Feiyu; Zhi, Linjie

    2012-12-11

    An acid-assisted ultrarapid thermal strategy is developed for constructing specifically functionalized graphene. The electrochemical performance of functionalized graphene can be boosted via elaborate coupling between the pseudocapacitance and the electronic double layer capacitance through rationally tailoring the structure of graphene sheets. This presents an opportunity for developing further high-performance graphene-based electrodes to bridge the performance gap between traditional capacitors and batteries. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Surgical procedures performed in the neonatal intensive care unit on critically ill neonates: feasibility and safety

    International Nuclear Information System (INIS)

    Mallick, M.S.; Jado, A.M.; Al-Bassam, A.R.

    2008-01-01

    Transferring unstable, ill neonates to and from the operating rooms carries significant risks and can lead to morbidity. We report on our experience in performing certain procedures in critically ill neonates in the neonatal intensive care unit (NICU). We examined the feasibility and safety for such an approach. All surgical procedures performed in the NICU between January 1999 and December 2005 were analyzed in terms of demographic data, diagnosis, preoperative stability of the patient, procedures performed, complications and outcome. Operations were performed at beside in the NICU in critically ill, unstable neonates who needed emergency surgery, in neonates of low birth weight (<1000 gm) and in neonates on special equipments like higher frequency ventilators and nitrous oxide. Thirty-seven surgical procedures were performed including 12 laparotomies, bowel resection and stomies, 7 repairs of congenital diaphragmatic hernias, 4 ligations of patent ductus arteriosus and various others. Birth weights ranged between 850 gm and 3500 gm (mean 2000 gm). Gestational age ranged between 25 to 42 weeks (mean, 33 weeks). Age at surgery was between 1 to 30 days (mean, 30 days). Preoperatively, 19 patients (51.3%) were on inotropic support and all were intubated and mechanically ventilated. There was no mortality related to surgical procedures. Postoperatively, one patient developed wound infection and disruption. Performing major surgical procedures in the NICU is both feasible and safe. It is useful in very low birth weight, critically ill neonates who have definite risk attached to transfer to the operating room. No special area is needed in the NICU to perform complication-free surgery, but designing an operating room within the NICU will be ideal. (author)

  3. Measuring functional, interactive and critical health literacy of Chinese secondary school students: reliable, valid and feasible?

    Science.gov (United States)

    Guo, Shuaijun; Davis, Elise; Yu, Xiaoming; Naccarella, Lucio; Armstrong, Rebecca; Abel, Thomas; Browne, Geoffrey; Shi, Yanqin

    2018-04-01

    Health literacy is an increasingly important topic in the global context. In mainland China, health literacy measures mainly focus on health knowledge and practices or on the functional domain for adolescents. However, little is known about interactive and critical domains. This study aimed to adopt a skills-based and three-domain (functional, interactive and critical) instrument to measure health literacy in Chinese adolescents and to examine the status and determinants of each domain. Using a systematic review, the eight-item Health Literacy Assessment Tool (HLAT-8) was selected and translated from English to Chinese (c-HLAT-8). Following the translation process, a cross-sectional study was conducted in four secondary schools in Beijing, China. A total of 650 students in Years 7-9 were recruited to complete a self-administered questionnaire that assessed socio-demographics, self-efficacy, social support, school environment, community environment and health literacy. Results showed that the c-HLAT-8 had satisfactory reliability (Cronbach's α = 0.79; intra-class correlation coefficient = 0.72) and strong validity (translation validity index (TVI) ≥0.95; χ 2 / df = 3.388, p students had an average score of 26.37 (±5.89) for the c-HLAT-8. When the determinants of each domain of health literacy were examined, social support was the strongest predictor of interactive and critical health literacy. On the contrary, self-efficacy and school environment played more dominant roles in predicting functional health literacy. The c-HLAT-8 was demonstrated to be a reliable, valid and feasible instrument for measuring functional, interactive and critical health literacy among Chinese students. The current findings indicate that increasing self-efficacy, social support and creating supportive environments are important for promoting health literacy in secondary school settings in China.

  4. Critical values of the Yang-Yang functional in the quantum sine-Gordon model

    International Nuclear Information System (INIS)

    Lukyanov, Sergei L.

    2011-01-01

    The critical values of the Yang-Yang functional corresponding to the vacuum states of the sine-Gordon QFT in the finite-volume are studied. Two major applications are discussed: (i) generalization of Fendley-Saleur-Zamolodchikov relations to arbitrary values of the sine-Gordon coupling constant, and (ii) connection problem for a certain two-parameter family of solutions of the Painleve III equation.

  5. Development of alarm logics for critical function monitoring in SMART-P reactor

    Energy Technology Data Exchange (ETDEWEB)

    Seong, Seung Hwan; Hur, Seop; Seo, Jae Kwang; Lee, Tae Ho; Park, Cheon Tae; Kang, Han Ok

    2003-04-01

    The alarm logics for the critical functions of SMART-P reactor are developed, which are based on the those of Korean Standard Nuclear power Plant(KSNP). The SMART-P reactor is an integral typed nuclear power plant and has the some different design features compared to those of KSNP. It, however, has the similar features in critical functions because it is a kind of pressurized water reactor. The alarm logics for Critical Function Monitoring System(CFMS) in SMART-P are developed from those for CFMS in KSNP. The alarm logics of CFMS in only the primary loop are, therefore, developed, though the general CFMS covered the status of primary and secondary loop including the features of the containment. The specific setpoint of related variables related to the alarm logics will be developed after the specific designs of SMART-P are finished. In appendix, we describe the conceptual architecture and variables of display screens on CFMS according to the developed alarm logics.

  6. Performance analysis, quality function deployment and structured methods

    Science.gov (United States)

    Maier, M. W.

    Quality function deployment, (QFD), an approach to synthesizing several elements of system modeling and design into a single unit, is presented. Behavioral, physical, and performance modeling are usually considered as separate aspects of system design without explicit linkages. Structured methodologies have developed linkages between behavioral and physical models before, but have not considered the integration of performance models. QFD integrates performance models with traditional structured models. In this method, performance requirements such as cost, weight, and detection range are partitioned into matrices. Partitioning is done by developing a performance model, preferably quantitative, for each requirement. The parameters of the model become the engineering objectives in a QFD analysis and the models are embedded in a spreadsheet version of the traditional QFD matrices. The performance model and its parameters are used to derive part of the functional model by recognizing that a given performance model implies some structure to the functionality of the system.

  7. Functional impacts of ocean acidification in an ecologically critical foundation species.

    Science.gov (United States)

    Gaylord, Brian; Hill, Tessa M; Sanford, Eric; Lenz, Elizabeth A; Jacobs, Lisa A; Sato, Kirk N; Russell, Ann D; Hettinger, Annaliese

    2011-08-01

    Anthropogenic CO(2) is reducing the pH and altering the carbonate chemistry of seawater, with repercussions for marine organisms and ecosystems. Current research suggests that calcification will decrease in many species, but compelling evidence of impaired functional performance of calcium carbonate structures is sparse, particularly in key species. Here we demonstrate that ocean acidification markedly degrades the mechanical integrity of larval shells in the mussel Mytilus californianus, a critical community member on rocky shores throughout the northeastern Pacific. Larvae cultured in seawater containing CO(2) concentrations expected by the year 2100 (540 or 970 ppm) precipitated weaker, thinner and smaller shells than individuals raised under present-day seawater conditions (380 ppm), and also exhibited lower tissue mass. Under a scenario where mussel larvae exposed to different CO(2) levels develop at similar rates, these trends suggest a suite of potential consequences, including an exacerbated vulnerability of new settlers to crushing and drilling attacks by predators; poorer larval condition, causing increased energetic stress during metamorphosis; and greater risks from desiccation at low tide due to shifts in shell area to body mass ratios. Under an alternative scenario where responses derive exclusively from slowed development, with impacted individuals reaching identical milestones in shell strength and size by settlement, a lengthened larval phase could increase exposure to high planktonic mortality rates. In either case, because early life stages operate as population bottlenecks, driving general patterns of distribution and abundance, the ecological success of this vital species may be tied to how ocean acidification proceeds in coming decades.

  8. Reduced functional measure of cardiovascular reserve predicts admission to critical care unit following kidney transplantation.

    Directory of Open Access Journals (Sweden)

    Stephen M S Ting

    Full Text Available There is currently no effective preoperative assessment for patients undergoing kidney transplantation that is able to identify those at high perioperative risk requiring admission to critical care unit (CCU. We sought to determine if functional measures of cardiovascular reserve, in particular the anaerobic threshold (VO₂AT could identify these patients.Adult patients were assessed within 4 weeks prior to kidney transplantation in a University hospital with a 37-bed CCU, between April 2010 and June 2012. Cardiopulmonary exercise testing (CPET, echocardiography and arterial applanation tonometry were performed.There were 70 participants (age 41.7±14.5 years, 60% male, 91.4% living donor kidney recipients, 23.4% were desensitized. 14 patients (20% required escalation of care from the ward to CCU following transplantation. Reduced anaerobic threshold (VO₂AT was the most significant predictor, independently (OR = 0.43; 95% CI 0.27-0.68; p<0.001 and in the multivariate logistic regression analysis (adjusted OR = 0.26; 95% CI 0.12-0.59; p = 0.001. The area under the receiver-operating-characteristic curve was 0.93, based on a risk prediction model that incorporated VO₂AT, body mass index and desensitization status. Neither echocardiographic nor measures of aortic compliance were significantly associated with CCU admission.To our knowledge, this is the first prospective observational study to demonstrate the usefulness of CPET as a preoperative risk stratification tool for patients undergoing kidney transplantation. The study suggests that VO₂AT has the potential to predict perioperative morbidity in kidney transplant recipients.

  9. The influence of critical thinking skills on performance and progression in a pre-registration nursing program.

    Science.gov (United States)

    Pitt, Victoria; Powis, David; Levett-Jones, Tracy; Hunter, Sharyn

    2015-01-01

    The importance of developing critical thinking skills in preregistration nursing students is recognized worldwide. Yet, there has been limited exploration of how students' critical thinking skill scores on entry to pre-registration nursing education influence their academic and clinical performance and progression. The aim of this study was to: i) describe entry and exit critical thinking scores of nursing students enrolled in a three year bachelor of nursing program in Australia in comparison to norm scores; ii) explore entry critical thinking scores in relation to demographic characteristics, students' performance and progression. This longitudinal correlational study used the Health Sciences Reasoning Test (HSRT) to measure critical thinking skills in a sample (n=134) of students, at entry and exit (three years later). A one sample t-test was used to determine if differences existed between matched student critical thinking scores between entry and exit points. Academic performance, clinical performance and progression data were collected and correlations with entry critical thinking scores were examined. There was a significant relationship between critical thinking scores, academic performance and students' risk of failing, especially in the first semester of study. Critical thinking scores were predictive of program completion within three years. The increase in critical thinking scores from entry to exit was significant for the 28 students measured. In comparison to norm scores, entry level critical thinking scores were significantly lower, but exit scores were comparable. Critical thinking scores had no significant relationship to clinical performance. Entry critical thinking scores significantly correlate to academic performance and predict students risk of course failure and ability to complete a nursing degree in three years. Students' critical thinking scores are an important determinant of their success and as such can inform curriculum development and

  10. Effects of Classroom Assessment on the Critical Thinking and Academic Performance of Students

    Directory of Open Access Journals (Sweden)

    DR. EDGAR M. BAYLON, JR.

    2014-02-01

    Full Text Available The study was undertaken to evaluate the classroom assessment employed by the teachers, the critical-thinking and academic performance of the students in the laboratory high schools (LHS of Central Bicol State University of Agriculture, school year 2012-2013. The descriptive-evaluative, descriptive-correlation and descriptive-comparative methods of research were used. The findings revealed that only 11 out of 50 types of classroom assessment techniques are being used in the two laboratory high schools of CBSUA, namely: CDE-LHS and CDE–CSHB. Except for the use of human tableau or class modeling and application cards in few instances, the other techniques used by the teachers were classified as low-order thinking skills like “remembering” and “understanding”. “Applying”, “analyzing”, “evaluating” and “creating” were rarely used by the teachers. There were significant differences in the levels of critical thinking among the second year students in the two LHS along remembering, understanding, analyzing and evaluating while for third year high school students in the two LHS there was significant difference in evaluating but not significantly different with the rest of the levels. In terms of students’ academic performance in Science and “remembering”; English and “evaluating” in school A, there was a significant relationship between the level of critical thinking among students and their academic performance in the three subjects. The teacher-related factors along gender, marital status, employment status, and number of awards received, were significantly associated with the questioning skills of the teachers. In general, the findings indicated that there were significant association between the student-related factors and the different levels of critical thinking.

  11. Parametric Optimization of Some Critical Operating System Functions--An Alternative Approach to the Study of Operating Systems Design

    Science.gov (United States)

    Sobh, Tarek M.; Tibrewal, Abhilasha

    2006-01-01

    Operating systems theory primarily concentrates on the optimal use of computing resources. This paper presents an alternative approach to teaching and studying operating systems design and concepts by way of parametrically optimizing critical operating system functions. Detailed examples of two critical operating systems functions using the…

  12. The financial performance of rural hospitals and implications for elimination of the Critical Access Hospital program.

    Science.gov (United States)

    Holmes, George M; Pink, George H; Friedman, Sarah A

    2013-01-01

    To compare the financial performance of rural hospitals with Medicare payment provisions to those paid under prospective payment and to estimate the financial consequences of elimination of the Critical Access Hospital (CAH) program. Financial data for 2004-2010 were collected from the Healthcare Cost Reporting Information System (HCRIS) for rural hospitals. HCRIS data were used to calculate measures of the profitability, liquidity, capital structure, and financial strength of rural hospitals. Linear mixed models accounted for the method of Medicare reimbursement, time trends, hospital, and market characteristics. Simulations were used to estimate profitability of CAHs if they reverted to prospective payment. CAHs generally had lower unadjusted financial performance than other types of rural hospitals, but after adjustment for hospital characteristics, CAHs had generally higher financial performance. Special payment provisions by Medicare to rural hospitals are important determinants of financial performance. In particular, the financial condition of CAHs would be worse if they were paid under prospective payment. © 2012 National Rural Health Association.

  13. Report on the 2011 Critical Assessment of Function Annotation (CAFA) meeting

    Energy Technology Data Exchange (ETDEWEB)

    Friedberg, Iddo [Miami Univ., Oxford, OH (United States)

    2015-01-21

    The Critical Assessment of Function Annotation meeting was held July 14-15, 2011 at the Austria Conference Center in Vienna, Austria. There were 73 registered delegates at the meeting. We thank the DOE for this award. It helped us organize and support a scientific meeting AFP 2011 as a special interest group (SIG) meeting associated with the ISMB 2011 conference. The conference was held in Vienna, Austria, in July 2011. The AFP SIG was held on July 15-16, 2011 (immediately preceding the conference). The meeting consisted of two components, the first being a series of talks (invited and contributed) and discussion sections dedicated to protein function research, with an emphasis on the theory and practice of computational methods utilized in functional annotation. The second component provided a large-scale assessment of computational methods through participation in the Critical Assessment of Functional Annotation (CAFA). The meeting was exciting and, based on feedback, quite successful. There were 73 registered participants. The schedule was only slightly different from the one proposed, due to two cancellations. Dr. Olga Troyanskaya has canceled and we invited Dr. David Jones instead. Similarly, instead of Dr. Richard Roberts, Dr. Simon Kasif gave a closing keynote. The remaining invited speakers were Janet Thornton (EBI) and Amos Bairoch (University of Geneva).

  14. The Functional Task Test (FTT): An Interdisciplinary Testing Protocol to Investigate the Factors Underlying Changes in Astronaut Functional Performance

    Science.gov (United States)

    Bloomberg, J. J.; Lawrence, E. L.; Arzeno, N. M.; Buxton, R. E.; Feiveson, A. H.; Kofman, I. S.; Lee, S. M. C.; Mulavara, A. P.; Peters, B. T.; Platts. S. H.; hide

    2011-01-01

    Exposure to space flight causes adaptations in multiple physiological systems including changes in sensorimotor, cardiovascular, and neuromuscular systems. These changes may affect a crewmember s ability to perform critical mission tasks immediately after landing on a planetary surface. The overall goal of this project is to determine the effects of space flight on functional tests that are representative of high priority exploration mission tasks and to identify the key underlying physiological factors that contribute to decrements in performance. To achieve this goal we developed an interdisciplinary testing protocol (Functional Task Test, FTT) that evaluates both astronaut functional performance and related physiological changes. Functional tests include ladder climbing, hatch opening, jump down, manual manipulation of objects and tool use, seat egress and obstacle avoidance, recovery from a fall and object translation tasks. Physiological measures include assessments of postural and gait control, dynamic visual acuity, fine motor control, plasma volume, orthostatic intolerance, upper- and lower-body muscle strength, power, endurance, control, and neuromuscular drive. Crewmembers perform this integrated test protocol before and after short (Shuttle) and long-duration (ISS) space flight. Data are collected on two sessions before flight, on landing day (Shuttle only) and 1, 6 and 30 days after landing. Preliminary results from both Shuttle and ISS crewmembers indicate decrement in performance of the functional tasks after both short and long-duration space flight. On-going data collection continues to improve the statistical power required to map changes in functional task performance to alterations in physiological systems. The information obtained from this study will be used to design and implement countermeasures that specifically target the physiological systems most responsible for the altered functional performance associated with space flight.

  15. Assessing air medical crew real-time readiness to perform critical tasks.

    Science.gov (United States)

    Braude, Darren; Goldsmith, Timothy; Weiss, Steven J

    2011-01-01

    Air medical transport has had problems with its safety record, attributed in part to human error. Flight crew members (FCMs) must be able to focus on critical safety tasks in the context of a stressful environment. Flight crew members' cognitive readiness (CR) to perform their jobs may be affected by sleep deprivation, personal problems, high workload, and use of alcohol and drugs. The current study investigated the feasibility of using a computer-based cognitive task to assess FCMs' readiness to perform their job. The FCMs completed a short questionnaire to evaluate their physiologic and psychological state at the beginning and end of each shift. The FCMs then performed 3 minutes of a computer-based cognitive task called synthetic work environment (SYNWIN test battery). Task performance was compared with the questionnaire variables using correlation and regression analysis. Differences between the beginning and end of each shift were matched and compared using a paired Students t test. SYNWIN performance was significantly worse at the end of a shift compared with the beginning of the shift (p = 0.028) primarily because of decrement in the memory component. The SYNWIN composite scores were negatively correlated to degree of irritability felt by the participant, both before (r = -0.25) and after (r = -0.34) a shift and were significantly correlated with amount of sleep (0.22), rest (0.30), and life satisfaction (0.30). Performance by FCMs on a simple, rapid, computer-based psychological test correlates well with self-reported sleep, rest, life satisfaction, and irritability. Although further studies are warranted, these findings suggest that assessment of the performance of FCMs on a simple, rapid, computer-based, multitasking battery is feasible as an approach to determine their readiness to perform critical safety tasks through the SYNWIN task battery.

  16. Ordering Interfluves: a Simple Proposal for Understanding Critical Zone Evolution and Function

    Science.gov (United States)

    Brecheisen, Z. S.; Richter, D., Jr.; Moon, S.; Halpin, P. N.

    2015-12-01

    A geomorphic interfluve ordering system, a reciprocal to the Hortonian-Strahler stream network order, is envisioned at the Calhoun Critical Zone Observatory (CCZO) in the South Carolina Piedmont. In this system the narrowest and most highly dissected interfluves (gentle ridges and hilltops) are 1st order and increase in rank dendritically through interfluve branching and broadening. Interfluve order attends to the structure, function, and management of residual porous-solid systems in the transport of water, solutes, and eroded solids in our deeply weathered (>30m soil/saprolite) critical zone. Recently generated geospatial data regarding the interactions of geomorphology, human land use, and forest ecology further strengthen the utility of this system. These upland networks and corresponding "land-sheds" have potential in linking recent work in the fields of geophysics and geomorphology regarding bedrock weathering front dynamics. Patterns of bedrock weathering depth, landcover & land-use change, and soil erosion are considered as they correspond to interfluve order. With LiDAR mapping and the burgeoning development and utilization of geophysical techniques and models enabling new quantitative research of critical zone landscape structure and function, many physiographic regions could benefit from a system that delineates and orders interfluve networks.

  17. Critical heat flux performance of hypervapotrons proposed for use in the ITER divertor vertical target

    International Nuclear Information System (INIS)

    Youchison, D.L.; Marshall, T.D.; McDonald, J.M.; Lutz, T.J.; Watson, R.D.; Driemeyer, D.E.; Kubik, D.L.; Slattery, K.T.; Hellwig, T.H.

    1997-09-01

    Task T-222 of the International Thermonuclear Experimental Reactor (ITER) program addresses the manufacturing and testing of permanent components for use in the ITER divertor. Thermalhydraulic and critical heat flux performance of the heat sinks proposed for use in the divertor vertical target are part of subtask T-222.4. As part of this effort, two single channel, medium scale, bare copper alloy, hypervapotron mockups were designed, fabricated, and tested using the EB-1200 electron beam system. The objectives of the effort were to develop the design and manufacturing procedures required for construction of robust high heat flux (HHF) components, verify thermalhydraulic, thermomechanical and critical heat flux (CHF) performance under ITER relevant conditions, and perform analyses of HHF data to identify design guidelines and failure criteria and possibly modify any applicable CHF correlations. The design, fabrication, and finite element modeling of two types of hypervapotrons are described; a common version already in use at the Joint European Torus (JET) and a new attached fin design. HHF test data on the attached fin hypervapotron will be used to compare the CHF performance under uniform heating profiles on long heated lengths with that of localized, highly peaked, off nominal profiles

  18. Identifying Critical Success Factors for TQM and Employee Performance in Malaysian Automotive Industry: A Literature Review

    Science.gov (United States)

    Nadia Dedy, Aimie; Zakuan, Norhayati; Zaidi Bahari, Ahamad; Ariff, Mohd Shoki Md; Chin, Thoo Ai; Zameri Mat Saman, Muhamad

    2016-05-01

    TQM is a management philosophy embracing all activities through which the needs and expectations of the customer and the community and the goals of the companies are satisfied in the most efficient and cost effective way by maximizing the potential of all workers in a continuing drive for total quality improvement. TQM is very important to the company especially in automotive industry in order for them to survive in the competitive global market. The main objective of this study is to review a relationship between TQM and employee performance. Authors review updated literature on TQM study with two main targets: (a) evolution of TQM considering as a set of practice, (b) and its impacts to employee performance. Therefore, two research questions are proposed in order to review TQM constructs and employee performance measure: (a) Is the set of critical success factors associated with TQM valid as a whole? (b) What is the critical success factors should be considered to measure employee performance in automotive industry?

  19. Critical heat flux performance of hypervapotrons proposed for use in the ITER divertor vertical target

    Energy Technology Data Exchange (ETDEWEB)

    Youchison, D.L.; Marshall, T.D.; McDonald, J.M.; Lutz, T.J.; Watson, R.D. [Sandia National Labs., Albuquerque, NM (United States); Driemeyer, D.E. Kubik, D.L.; Slattery, K.T.; Hellwig, T.H. [McDonnell Douglas Aerospace, St. Louis, MO (United States)

    1997-09-01

    Task T-222 of the International Thermonuclear Experimental Reactor (ITER) program addresses the manufacturing and testing of permanent components for use in the ITER divertor. Thermalhydraulic and critical heat flux performance of the heat sinks proposed for use in the divertor vertical target are part of subtask T-222.4. As part of this effort, two single channel, medium scale, bare copper alloy, hypervapotron mockups were designed, fabricated, and tested using the EB-1200 electron beam system. The objectives of the effort were to develop the design and manufacturing procedures required for construction of robust high heat flux (HHF) components, verify thermalhydraulic, thermomechanical and critical heat flux (CHF) performance under ITER relevant conditions, and perform analyses of HHF data to identify design guidelines and failure criteria and possibly modify any applicable CHF correlations. The design, fabrication, and finite element modeling of two types of hypervapotrons are described; a common version already in use at the Joint European Torus (JET) and a new attached fin design. HHF test data on the attached fin hypervapotron will be used to compare the CHF performance under uniform heating profiles on long heated lengths with that of localized, highly peaked, off nominal profiles.

  20. M&A Performance and Economic Impact: Integration and Critical Assessment of Methodological Approach

    Directory of Open Access Journals (Sweden)

    Karolis Andriuskevicius

    2017-11-01

    Full Text Available Purpose of the article: Existing methodologies employed within the M&A performance framework are investigated and critically discuss. Methodology/methods: The research has been carried out as a structured assessment of past literature. The findings from scientific articles and studies by various scholars have been categorized, grouped and summarized to discern a meta-analytic view of the work carried out to date. Scientific aim: The conducted research seeks to ascertain and evaluate theoretically existing methodologies used in empirical studies that would allow proper and critical understanding of the results of various findings in the holistic and global M&As area. Findings: The research elaborates on several key developments in M&A methodology and performance studies carried out in empirical works during the last two decades. The findings help to independently and objectively assess performance of M&A from a holistic perspective. Conclusions: Each methodology measuring either M&A performance on a corporate level or effects of M&A on the economy level shall be interpreted and relied on with caution as each of them dispose their limitations whereas application of these methodologies is subject to data availability and case specific.

  1. UPF2 is a critical regulator of liver development, function and regeneration

    DEFF Research Database (Denmark)

    Thoren, Lina A; Nørgaard, Gitte A; Weischenfeldt, Joachim

    2010-01-01

    regulatory potential of the NMD pathway in mammals will require the functional assessment of NMD in different tissues. METHODOLOGY/PRINCIPAL FINDINGS: Here we use mouse genetics to address the role of UPF2, a core NMD component, in the development, function and regeneration of the liver. We find that loss....... CONCLUSION/SIGNIFICANCE: Collectively, our data demonstrate the critical role of the NMD pathway in liver development, function and regeneration and highlights the importance of NMD for mammalian biology....... of NMD during fetal liver development is incompatible with postnatal life due to failure of terminal differentiation. Moreover, deletion of Upf2 in the adult liver results in hepatosteatosis and disruption of liver homeostasis. Finally, NMD was found to be absolutely required for liver regeneration...

  2. Enhancement of biomembrane functions under phase-separated conditions: A self-organized criticality phenomenon?

    International Nuclear Information System (INIS)

    Eze, M.O.; Chela Flores, J.

    1993-12-01

    Self-organized criticality (SOC) is hereby proposed as a possible physical basis for explaining observations in the temperature-dependence of the rates of biological membrane-associated events. The biomembrane undergoes a reversible, cooperative, thermotropic gel-to-liquid crystalline phase transition which is broad, and involves lateral phase separation. The lateral phase separated (rather than the totally gel-, or the totally liquid crystalline-) membrane state has been observed to be the state in which vital membrane functions are facilitated. The membrane in this unique state is viewed, for our purposes here, as a dynamical, extended dissipative system with spatial and temporal degrees of freedom, exhibiting power law behaviour, typical of the self-organized critical state. Experiments are suggested for verifying this hypothesis. (author). 30 refs

  3. Functionalized graphene hydrogel-based high-performance supercapacitors.

    Science.gov (United States)

    Xu, Yuxi; Lin, Zhaoyang; Huang, Xiaoqing; Wang, Yang; Huang, Yu; Duan, Xiangfeng

    2013-10-25

    Functionalized graphene hydrogels are prepared by a one-step low-temperature reduction process and exhibit ultrahigh specific capacitances and excellent cycling stability in the aqueous electrolyte. Flexible solid-state supercapacitors based on functionalized graphene hydrogels are demonstrated with superior capacitive performances and extraordinary mechanical flexibility. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Is performance better when brain functions are typically lateralized?

    NARCIS (Netherlands)

    Geuze, Reint; Zickert, Nele; Beking, Tess; Groothuis, Antonius

    2014-01-01

    Lateralization refers to the dominant involvement of one homologous region of the brain over the other in functional task performance. Direction and strength of lateralization depend on the functional task. It is well known that language is lateralized to the left hemisphere, even in most

  5. Environmental drivers of soil microbial community structure and function at the Avon River Critical Zone Observatory.

    Science.gov (United States)

    Gleeson, Deirdre; Mathes, Falko; Farrell, Mark; Leopold, Matthias

    2016-11-15

    The Critical Zone is defined as the thin, permeable layer from the tops of the trees to the bottom of the bedrock that sustains terrestrial life on Earth. The geometry and shape of the various weathering zones are known as the critical zone architecture. At the centre of the Critical Zone are soils and the microorganisms that inhabit them. In Western Australia, the million-year-old stable weathering history and more recent lateral erosion during the past hundreds of thousands of years have created a geomorphic setting where deep weathering zones are now exposed on the surface along the flanks of many lateritic hills. These old weathering zones provide diverse physical and chemical properties that influence near surface pedologic conditions and thus likely shape current surface microbiology. Here, we present data derived from a small lateritic hill on the UWA Farm Ridgefield. Spatial soil sampling revealed the contrasting distribution patterns of simple soil parameters such as pH (CaCl2) and electric conductivity. These are clearly linked with underlying changes of the critical zone architecture and show a strong contrast with low values of pH3.3 at the top of the hill to pH5.3 at the bottom. These parameters were identified as major drivers of microbial spatial variability in terms of bacterial and archaeal community composition but not abundance. In addition, we used sensitive (14)C labelling to assess turnover of three model organic nitrogen compounds - an important biogeochemical functional trait relating to nutrient availability. Though generally rapid and in the order of rates reported elsewhere (t½10h). In conclusion, we have shown that the weathering and erosion history of ancient Western Australia affects the surface pedology and has consequences for microbial community structure and function. Copyright © 2016 Elsevier B.V. All rights reserved.

  6. Performance of MPI parallel processing implemented by MCNP5/ MCNPX for criticality benchmark problems

    International Nuclear Information System (INIS)

    Mark Dennis Usang; Mohd Hairie Rabir; Mohd Amin Sharifuldin Salleh; Mohamad Puad Abu

    2012-01-01

    MPI parallelism are implemented on a SUN Workstation for running MCNPX and on the High Performance Computing Facility (HPC) for running MCNP5. 23 input less obtained from MCNP Criticality Validation Suite are utilized for the purpose of evaluating the amount of speed up achievable by using the parallel capabilities of MPI. More importantly, we will study the economics of using more processors and the type of problem where the performance gain are obvious. This is important to enable better practices of resource sharing especially for the HPC facilities processing time. Future endeavours in this direction might even reveal clues for best MCNP5/ MCNPX coding practices for optimum performance of MPI parallelisms. (author)

  7. Critical Role of Monoclinic Polarization Rotation in High-Performance Perovskite Piezoelectric Materials.

    Science.gov (United States)

    Liu, Hui; Chen, Jun; Fan, Longlong; Ren, Yang; Pan, Zhao; Lalitha, K V; Rödel, Jürgen; Xing, Xianran

    2017-07-07

    High-performance piezoelectric materials constantly attract interest for both technological applications and fundamental research. The understanding of the origin of the high-performance piezoelectric property remains a challenge mainly due to the lack of direct experimental evidence. We perform in situ high-energy x-ray diffraction combined with 2D geometry scattering technology to reveal the underlying mechanism for the perovskite-type lead-based high-performance piezoelectric materials. The direct structural evidence reveals that the electric-field-driven continuous polarization rotation within the monoclinic plane plays a critical role to achieve the giant piezoelectric response. An intrinsic relationship between the crystal structure and piezoelectric performance in perovskite ferroelectrics has been established: A strong tendency of electric-field-driven polarization rotation generates peak piezoelectric performance and vice versa. Furthermore, the monoclinic M_{A} structure is the key feature to superior piezoelectric properties as compared to other structures such as monoclinic M_{B}, rhombohedral, and tetragonal. A high piezoelectric response originates from intrinsic lattice strain, but little from extrinsic domain switching. The present results will facilitate designing high-performance perovskite piezoelectric materials by enhancing the intrinsic lattice contribution with easy and continuous polarization rotation.

  8. Critical Quality Source Diagnosis for Dam Concrete Construction Based on Quality Gain-loss Function

    Directory of Open Access Journals (Sweden)

    Bo Wang

    2014-06-01

    Full Text Available In dam concrete construction process, it not only has quality loss arising from quality fluctuation, but also gains quality compensation effect due to the mutual cooperation and adaptation coupling between working procedures (WPs. The calculation and transmission complexity of the quality loss and quality compensation affect the quality management of dam concrete construction. As the quality compensation effect existing in the production practice cannot be described by Taguchi quality loss function, the concept of quality gain-loss function was presented in this paper, which was based on endowing the constant term in the expansion of Taylor series with physical meaning—quality compensation. Based on quality gain-loss function theory, a new quality gain-loss transmission model of dam concrete construction based on GERT network was constructed and its effective algorithm was designed. WP quality gain-loss and its impact on the final product were reasonably measured, and the critical quality routes and critical quality WPs were detected and diagnosed in dam concrete construction network. Summer temperature-controlled concrete construction in the third phase of Three Gorges Project (TGP was taken as an example to carry out the study, and the calculation results showed the validity and practicability of the presented model and algorithm.

  9. The influence of anaesthetists' experience on workload, performance and visual attention during simulated critical incidents.

    Science.gov (United States)

    Schulz, Christian M; Schneider, Erich; Kohlbecher, Stefan; Hapfelmeier, Alexander; Heuser, Fabian; Wagner, Klaus J; Kochs, Eberhard F; Schneider, Gerhard

    2014-10-01

    Development of accurate Situation Awareness (SA) depends on experience and may be impaired during excessive workload. In order to gain adequate SA for decision making and performance, anaesthetists need to distribute visual attention effectively. Therefore, we hypothesized that in more experienced anaesthetists performance is better and increase of physiological workload is less during critical incidents. Additionally, we investigated the relation between physiological workload indicators and distribution of visual attention. In fifteen anaesthetists, the increase of pupil size and heart rate was assessed in course of a simulated critical incident. Simulator log files were used for performance assessment. An eye-tracking device (EyeSeeCam) provided data about the anaesthetists' distribution of visual attention. Performance was assessed as time until definitive treatment. T tests and multivariate generalized linear models (MANOVA) were used for retrospective statistical analysis. Mean pupil diameter increase was 8.1% (SD ± 4.3) in the less experienced and 15.8% (±10.4) in the more experienced subjects (p = 0.191). Mean heart rate increase was 10.2% (±6.7) and 10.5% (±8.3, p = 0.956), respectively. Performance did not depend on experience. Pupil diameter and heart rate increases were associated with a shift of visual attention from monitoring towards manual tasks (not significant). For the first time, the following four variables were assessed simultaneously: physiological workload indicators, performance, experience, and distribution of visual attention between "monitoring" and "manual" tasks. However, we were unable to detect significant interactions between these variables. This experimental model could prove valuable in the investigation of gaining and maintaining SA in the operation theatre.

  10. Modularization, inter-functional integration and operational performance

    DEFF Research Database (Denmark)

    Boer, Henrike Engele Elisabeth; Boer, Harry

    2014-01-01

    for firms to indeed use product modularity beneficially, in particular inter-functional integration between manufacturing and purchasing, design and sales, respectively. The purpose of the paper is to investigate the direct performance effects of modularization, as well as the mediating effects of the three...... forms of integration in the modularization-performance relationship....

  11. On the applicability of the critical safety function concept to a uranium hexafluoride conversion unit

    International Nuclear Information System (INIS)

    Santos, F.C.; Goncalves, J.S.; Melo, P.F. Frutuoso e; Medeiros, J.A.C.C.

    2013-01-01

    This paper presents a discussion on the applicability on the critical safety function (CSF) concept as a design criterion for the new UF 6 conversion plant of Industrias Nucleares do Brazil (INB). This discussion is in the context of accident management, under the safety function oriented management. Safety functions may be understood as those whose loss may lead to releases of radioactive material or highly toxic chemicals, having possible radiological and/or occupational consequences for workers, the public or the environment. They should be designed to prevent criticality and to ensure adequate process confinement, thus preventing radioactive material releases that might lead to internal or external exposure and highly toxic chemical releases and exposure. The main hazards is the potential release of chemicals, especially HF and UF 6 . A criticality hazard exists only if the conversion facility processes uranium with a 235 U concentration greater than 1% Industrial activities for UF 6 production include handling and processing explosive, toxic and lethal chemicals, such as HF, H 2 and elemental F 2 , besides intermediate compounds containing uranium. State trees and definition of logical arrangements to construct an annunciation system are the next development stages, resulting form the establishment of applicable CSFs as representative of the next development stages, resulting from the establishment of applicable CSFs as representative of the various systems that make up the conversion plant. Discussed also in the biggest challenge of the development of this innovation, that is, the uncertainties related to the impact of human factors (not subject to monitoring by sensors or process conventional instrumentation). (author)

  12. On the applicability of the critical safety function concept to a uranium hexafluoride conversion unit

    Energy Technology Data Exchange (ETDEWEB)

    Santos, F.C.; Goncalves, J.S.; Melo, P.F. Frutuoso e; Medeiros, J.A.C.C., E-mail: fcruz@nuclear.ufrj.br, E-mail: jsgoncalves@inb.gov.br, E-mail: frutuoso@nuclear.ufrj.br, E-mail: canedo@imp.ufrj.br [Coordenacao dos Programas de Pos-Graduacao em Engenharia (COPPE/UFRJ), Rio de Janeiro, RJ (Brazil)

    2013-07-01

    This paper presents a discussion on the applicability on the critical safety function (CSF) concept as a design criterion for the new UF{sub 6} conversion plant of Industrias Nucleares do Brazil (INB). This discussion is in the context of accident management, under the safety function oriented management. Safety functions may be understood as those whose loss may lead to releases of radioactive material or highly toxic chemicals, having possible radiological and/or occupational consequences for workers, the public or the environment. They should be designed to prevent criticality and to ensure adequate process confinement, thus preventing radioactive material releases that might lead to internal or external exposure and highly toxic chemical releases and exposure. The main hazards is the potential release of chemicals, especially HF and UF{sub 6}. A criticality hazard exists only if the conversion facility processes uranium with a {sup 235}U concentration greater than 1% Industrial activities for UF{sub 6} production include handling and processing explosive, toxic and lethal chemicals, such as HF, H{sub 2} and elemental F{sub 2}, besides intermediate compounds containing uranium. State trees and definition of logical arrangements to construct an annunciation system are the next development stages, resulting form the establishment of applicable CSFs as representative of the next development stages, resulting from the establishment of applicable CSFs as representative of the various systems that make up the conversion plant. Discussed also in the biggest challenge of the development of this innovation, that is, the uncertainties related to the impact of human factors (not subject to monitoring by sensors or process conventional instrumentation). (author)

  13. The relationship between professional communication competences and nursing performance of critical care nurses in South Korea.

    Science.gov (United States)

    Song, Hyo-Suk; Choi, JiYeon; Son, Youn-Jung

    2017-10-01

    Ineffective communication of critical care nurses can lead to higher levels of burnout and negatively affect quality of patient care and patient outcomes such as higher mortality. The purpose of this study is to describe the relationship between professional communication competences and nursing performance of critical care nurses in South Korea. This cross-sectional study collected data on 197 intensive care unit staff nurses in 3 tertiary academic medical centres in South Korea from July to November 2014. In the hierarchical regression analysis, the professional communication competences were the only significant predictors of nursing performance after adjusting for sociodemographic characteristics. In addition, the greater professional communication competences of nurses were associated with being older and having a higher education level, more years of overall clinical and intensive care unit experience, and a higher monthly salary. Our findings indicate that communication skills-related training should be included in the practical education to improve nursing performance for the quality of intensive care. Further research is needed to identify the comprehensive factors on professional communication competences of nurses in intensive care units. © 2017 John Wiley & Sons Australia, Ltd.

  14. A novel PKD2L1 C-terminal domain critical for trimerization and channel function.

    Science.gov (United States)

    Zheng, Wang; Hussein, Shaimaa; Yang, JungWoo; Huang, Jun; Zhang, Fan; Hernandez-Anzaldo, Samuel; Fernandez-Patron, Carlos; Cao, Ying; Zeng, Hongbo; Tang, Jingfeng; Chen, Xing-Zhen

    2015-03-30

    As a transient receptor potential (TRP) superfamily member, polycystic kidney disease 2-like-1 (PKD2L1) is also called TRPP3 and has similar membrane topology as voltage-gated cation channels. PKD2L1 is involved in hedgehog signaling, intestinal development, and sour tasting. PKD2L1 and PKD1L3 form heterotetramers with 3:1 stoichiometry. C-terminal coiled-coil-2 (CC2) domain (G699-W743) of PKD2L1 was reported to be important for its trimerization but independent studies showed that CC2 does not affect PKD2L1 channel function. It thus remains unclear how PKD2L1 proteins oligomerize into a functional channel. By SDS-PAGE, blue native PAGE and mutagenesis we here identified a novel C-terminal domain called C1 (K575-T622) involved in stronger homotrimerization than the non-overlapping CC2, and found that the PKD2L1 N-terminus is critical for dimerization. By electrophysiology and Xenopus oocyte expression, we found that C1, but not CC2, is critical for PKD2L1 channel function. Our co-immunoprecipitation and dynamic light scattering experiments further supported involvement of C1 in trimerization. Further, C1 acted as a blocking peptide that inhibits PKD2L1 trimerization as well as PKD2L1 and PKD2L1/PKD1L3 channel function. Thus, our study identified C1 as the first PKD2L1 domain essential for both PKD2L1 trimerization and channel function, and suggest that PKD2L1 and PKD2L1/PKD1L3 channels share the PKD2L1 trimerization process.

  15. Experimental performance and results of the critical pebble bed facility KAHTER

    Energy Technology Data Exchange (ETDEWEB)

    Krings, F. J.; Drueke, V.; Kirch, N.; Neef, R. D.

    1974-10-15

    The paper provides a description and results of critical experiments performed in KAHTER fueled with pebbles containing coated particles of HEU/Th oxide with a ratio of uranium-to-thorium of 1.1:5. Core loadings with varying amounts of fuel and solid graphite pebbles were tested with fuel-to-graphite pebble ratios of 3:1, 1:1, and 1:3. Tests included criticality for various fuel loadings with all control rods removed, control rod worths for reflector-mounted control as single rods and in a bank and control worths for a central control rod, reaction rates by flux wire activations (Dy, Mn, In, Au, and U-235) and detector measurements (BF3 and fission chamber), simulated xenon stability testing using the motions of a Cf-252 source and Cd-absorber observed by an externally-located BF3 detector, and the reactivity worth of a Hf burnable absorber. For calculations of the room-temperature zero-power critical experiment, the values for nitrogen and hydrogen contents of the graphite were taken from previous experiments in CESAR.

  16. Muscle Functions and Functional Performance among Older Persons with and without Low Back Pain

    Directory of Open Access Journals (Sweden)

    Nor Azizah Ishak

    2016-01-01

    Full Text Available This study aims to compare muscle functions and functional performances between older persons with and without low back pain (LBP and to determine the association between muscle functions and functional performances. This is a cross-sectional study, involving 95 older persons (age = 70.27±7.26 years. Anthropometric characteristics, muscle functions, and functional performances were measured. Data were analyzed using ANOVA, Pearson’s correlation, and multiple linear regression. The functional performances showed no significant differences (females LBP versus non-LBP, males LBP versus non-LBP (p<0.05. For muscle functions, significant differences were found (females LBP versus non-LBP for abdominal muscle strength (p=0.006 and back muscle strength (p=0.07. In the LBP group, significant correlations were found between back and abdominal muscle strength and hand grip strength (r=0.377 and r=0.396, resp., multifidus control and lower limb function (r=0.363 in females, and back muscle strength and lower limb function (r=0.393 in males (all p<0.05. Regression analysis showed that abdominal and back muscle strengths were significant predictors of hand grip strength (p=0.041 and p=0.049, resp., and multifidus control was a significant predictor of lower limb function in females (p=0.047. This study demonstrates that older women with LBP exhibit poorer muscle functions compared to older women without LBP.

  17. Cognitive Performance associated to functional outcomes in stable outpatients with schizophrenia

    Directory of Open Access Journals (Sweden)

    Silvia Zaragoza Domingo, MA

    2015-09-01

    Conclusion: Most prevalent impairments were on executive function and processing speed domains; however, working memory showed the strongest relationship to functional disability. Monitoring cognitive function during follow up is critical to understand patient’s everyday functional capacity.

  18. Discerning Thermodynamic Basis of Self-Organization in Critical Zone Structure and Function

    Science.gov (United States)

    Richardson, M.; Kumar, P.

    2017-12-01

    Self-organization characterizes the spontaneous emergence of order. Self-organization in the Critical Zone, the region of Earth's skin from below the groundwater table to the top of the vegetation canopy, involves the interaction of biotic and abiotic processes occurring through a hierarchy of temporal and spatial scales. The self-organization is sustained through input of energy and material in an open system framework, and the resulting formations are called dissipative structures. Why do these local states of organization form and how are they thermodynamically favorable? We hypothesize that structure formation is linked to energy conversion and matter throughput rates across driving gradients. Furthermore, we predict that structures in the Critical Zone evolve based on local availability of nutrients, water, and energy. By considering ecosystems as open thermodynamic systems, we model and study the throughput signatures on short times scales to determine origins and characteristics of ecosystem structure. This diagnostic approach allows us to use fluxes of matter and energy to understand the thermodynamic drivers of the system. By classifying the fluxes and dynamics in a system, we can identify patterns to determine the thermodynamic drivers for organized states. Additionally, studying the partitioning of nutrients, water, and energy throughout ecosystems through dissipative structures will help identify reasons for structure shapes and how these shapes impact major Critical Zone functions.

  19. A comparison of educational strategies for the acquisition of nursing student's performance and critical thinking: simulation-based training vs. integrated training (simulation and critical thinking strategies).

    Science.gov (United States)

    Zarifsanaiey, Nahid; Amini, Mitra; Saadat, Farideh

    2016-11-16

    There is a need to change the focus of nursing education from traditional teacher-centered training programs to student-centered active methods. The integration of the two active learning techniques will improve the effectiveness of training programs. The objective of this study is to compare the effects of the integrated training (simulation and critical thinking strategies) and simulation-based training on the performance level and critical thinking ability of nursing students. The present quasi-experimental study was performed in 2014 on 40 students who were studying practical nursing principles and skills course in the first half of the academic year in Shiraz University of Medical Sciences. Students were randomly divided into control (n = 20) and experimental (n = 20) groups. After training students through simulation and integrated education (simulation and critical thinking strategies), the students' critical thinking ability and performance were evaluated via the use of California Critical Thinking Ability Questionnaire B (CCTST) and Objective Structured Clinical Examination (OSCE) comprising 10 stations, respectively. The external reliability of the California Critical Thinking questionnaire was reported by Case B.to be between 0.78 and 0.80 and the validity of OSCE was approved by 5 members of the faculty. Furthermore, by using Split Half method (the correlation between odd and even stations), the reliability of the test was approved with correlation coefficient of 0.66. Data were analyzed using t-test and Mann-Whitney test. A significance level of 0.05 was considered to be statistically significant. The mean scores of the experimental group performance level were higher than the mean score of the control group performance level. This difference was statistically significant and students in the experimental group in OSCE stations had significantly higher performance than the control group (P critical thinking did not increase before and after the

  20. The ALMT Gene Family Performs Multiple Functions in Plants

    Directory of Open Access Journals (Sweden)

    Jie Liu

    2018-02-01

    Full Text Available The aluminium activated malate transporter (ALMT gene family is named after the first member of the family identified in wheat (Triticum aestivum L.. The product of this gene controls resistance to aluminium (Al toxicity. ALMT genes encode transmembrane proteins that function as anion channels and perform multiple functions involving the transport of organic anions (e.g., carboxylates and inorganic anions in cells. They share a PF11744 domain and are classified in the Fusaric acid resistance protein-like superfamily, CL0307. The proteins typically have five to seven transmembrane regions in the N-terminal half and a long hydrophillic C-terminal tail but predictions of secondary structure vary. Although widely spread in plants, relatively little information is available on the roles performed by other members of this family. In this review, we summarized functions of ALMT gene families, including Al resistance, stomatal function, mineral nutrition, microbe interactions, fruit acidity, light response and seed development.

  1. Immune Monitoring in Cancer Vaccine Clinical Trials: Critical Issues of Functional Flow Cytometry-Based Assays

    Directory of Open Access Journals (Sweden)

    Iole Macchia

    2013-01-01

    Full Text Available The development of immune monitoring assays is essential to determine the immune responses against tumor-specific antigens (TSAs and tumor-associated antigens (TAAs and their possible correlation with clinical outcome in cancer patients receiving immunotherapies. Despite the wide range of techniques used, to date these assays have not shown consistent results among clinical trials and failed to define surrogate markers of clinical efficacy to antitumor vaccines. Multiparameter flow cytometry- (FCM- based assays combining different phenotypic and functional markers have been developed in the past decade for informative and longitudinal analysis of polyfunctional T-cells. These technologies were designed to address the complexity and functional heterogeneity of cancer biology and cellular immunity and to define biomarkers predicting clinical response to anticancer treatment. So far, there is still a lack of standardization of some of these immunological tests. The aim of this review is to overview the latest technologies for immune monitoring and to highlight critical steps involved in some of the FCM-based cellular immune assays. In particular, our laboratory is focused on melanoma vaccine research and thus our main goal was the validation of a functional multiparameter test (FMT combining different functional and lineage markers to be applied in clinical trials involving patients with melanoma.

  2. Diabetes, child care, and performance of family functions

    Directory of Open Access Journals (Sweden)

    Ewa Kobos

    2017-03-01

    Full Text Available Introduction : Parents caring for a child with diabetes may experience a burden on both a practical and an emotional level. Aim of the research : Analysis of the correlations between the care burden level and the perceived influence of type 1 diabetes in children on the performance of family functions. Material and methods : The study included 112 caregivers of children with diabetes. The following inclusion criteria were taken into account: full family, direct caregiver of the child, the child’s age 3–16 years, disease duration of at least 6 months, and no chronic diseases in siblings. The study material was collected using an interview questionnaire and the Caregiver Burden Scale. Correlation analysis was performed using the Spearman correlation coefficient. The significance level was defined as p = 0.05. Results : A higher burden level of a caregiver in the individual subscales of the CB Scale was associated with a significant decrease in the intensity of performance of the cultural and social function as well as consumption function, the increased amount of time spent with a sick child, and an increase in parental disagreements. The overall burden level differentiated the performance of the religious function. An increase in the burden level on the overall effort subscale was accompanied by lower interest in sex and less frequent sexual intercourse. The higher level of caregiver burden occurs in families where permanent job income has fallen. The differences were shown in the performance of control-socialisation function due to the sense of burden on the environment subscale. Conclusions : The burden level of a caregiver is important in the perceived influence of the child’s illness on the functioning of the family. Stimulating a caregiver in dealing with the problems that are the consequence of the disease, as well as activating and preparing other family members to participate in the care of a sick child, and financial support may

  3. NMDA receptor function during senescence: implication on cognitive performance

    Directory of Open Access Journals (Sweden)

    Ashok eKumar

    2015-12-01

    Full Text Available N-methyl-D-aspartate (NMDA receptors, a family of L-glutamate receptors, play an important role in learning and memory, and are critical for spatial memory. These receptors are tetrameric ion channels composed of a family of related subunits. One of the hallmarks of the aging human population is a decline in cognitive function; studies in the past couple of years have demonstrated deterioration in NMDA receptor subunit expression and function with advancing age. However, a direct relationship between impaired memory function and a decline in NMDA receptors is still ambiguous. Recent studies indicate a link between an age-associated NMDA receptor hypofunction and memory impairment and provide evidence that age-associated enhanced oxidative stress might be contributing to the alterations associated with senescence. However, clear evidence is still deficient in demonstrating the underlying mechanisms and a relationship between age-associated impaired cognitive faculties and NMDA receptor hypofunction. The current review intends to present an overview of the research findings regarding changes in expression of various NMDA receptor subunits and deficits in NMDA receptor function during senescence and its implication in age-associated impaired hippocampal-dependent memory function.

  4. Functional disability and suicidal behavior in middle-aged and older adults: A systematic critical review.

    Science.gov (United States)

    Lutz, Julie; Fiske, Amy

    2018-02-01

    Middle-aged and older adults have elevated rates of suicide around the globe, but there is a paucity of knowledge about risk factors for suicide in these age groups. One possible risk factor may be functional disability, which is more common at later ages. The current systematic critical review examined findings regarding the associations between functional disability and suicidal behavior (suicidal ideation, suicide attempts, and death by suicide) in middle-aged and older adults (i.e. age 50 and older). Forty-five studies were found that examined these associations. The majority of studies supported a significant association between functional disability and suicidal ideation. In addition, findings to date strongly suggest that depression serves as a mediator of the association between functional disability and suicidal ideation, though most studies did not directly test for mediation. Firm conclusions regarding suicide attempts and death by suicide, as well as mediation, cannot be drawn due to a relative lack of research in these areas. The association between functional disability and suicidal behavior suggests an important area for prevention and intervention among middle-aged and older adults, but additional research is necessary to clarify the specifics of these associations and examine appropriate intervention strategies. Important future directions for research in this area include the direct comparison of associations of risk factors with different types of suicidal behavior, greater use of longitudinal data with multiple time points, and further examination of potential mediators and moderators of the association between functional disability and suicidal behavior. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Altering endocannabinoid neurotransmission at critical developmental ages: impact on rodent emotionality and cognitive performance

    Directory of Open Access Journals (Sweden)

    Viviana eTrezza

    2012-01-01

    Full Text Available The endocannabinoid system shows functional activity from early stages of brain development: it plays an important role in fundamental developmental processes such as cell proliferation, migration and differentiation, thus shaping brain organization during pre- and postnatal life. Cannabis sativa preparations are among the illicit drugs most commonly used by young people, including pregnant women. The developing brain can be therefore exposed to cannabis preparations during two critical periods: first, in offspring of cannabis-using mothers through perinatal and/or prenatal exposure; second, in adolescent cannabis users during neural maturation. In the last decade, it has become clear that the endocannabinoid system critically modulates memory processing and emotional responses. Therefore, it is well possible that developmental exposure to cannabinoid compounds induces enduring changes in behaviors and neural processes belonging to the cognitive and emotional domains. We address this issue by focusing on rodent studies, in order to provide a framework for understanding the impact of cannabinoid exposure on the developing brain.

  6. Stormwater management network effectiveness and implications for urban watershed function: A critical review

    Science.gov (United States)

    Jefferson, Anne J.; Bhaskar, Aditi S.; Hopkins, Kristina G.; Fanelli, Rosemary; Avellaneda, Pedro M.; McMillan, Sara K.

    2017-01-01

    Deleterious effects of urban stormwater are widely recognized. In several countries, regulations have been put into place to improve the conditions of receiving water bodies, but planning and engineering of stormwater control is typically carried out at smaller scales. Quantifying cumulative effectiveness of many stormwater control measures on a watershed scale is critical to understanding how small-scale practices translate to urban river health. We review 100 empirical and modelling studies of stormwater management effectiveness at the watershed scale in diverse physiographic settings. Effects of networks with stormwater control measures (SCMs) that promote infiltration and harvest have been more intensively studied than have detention-based SCM networks. Studies of peak flows and flow volumes are common, whereas baseflow, groundwater recharge, and evapotranspiration have received comparatively little attention. Export of nutrients and suspended sediments have been the primary water quality focus in the United States, whereas metals, particularly those associated with sediments, have received greater attention in Europe and Australia. Often, quantifying cumulative effects of stormwater management is complicated by needing to separate its signal from the signal of urbanization itself, innate watershed characteristics that lead to a range of hydrologic and water quality responses, and the varying functions of multiple types of SCMs. Biases in geographic distribution of study areas, and size and impervious surface cover of watersheds studied also limit our understanding of responses. We propose hysteretic trajectories for how watershed function responds to increasing imperviousness and stormwater management. Even where impervious area is treated with SCMs, watershed function may not be restored to its predevelopment condition because of the lack of treatment of all stormwater generated from impervious surfaces; non-additive effects of individual SCMs; and

  7. Accessible high performance computing solutions for near real-time image processing for time critical applications

    Science.gov (United States)

    Bielski, Conrad; Lemoine, Guido; Syryczynski, Jacek

    2009-09-01

    High Performance Computing (HPC) hardware solutions such as grid computing and General Processing on a Graphics Processing Unit (GPGPU) are now accessible to users with general computing needs. Grid computing infrastructures in the form of computing clusters or blades are becoming common place and GPGPU solutions that leverage the processing power of the video card are quickly being integrated into personal workstations. Our interest in these HPC technologies stems from the need to produce near real-time maps from a combination of pre- and post-event satellite imagery in support of post-disaster management. Faster processing provides a twofold gain in this situation: 1. critical information can be provided faster and 2. more elaborate automated processing can be performed prior to providing the critical information. In our particular case, we test the use of the PANTEX index which is based on analysis of image textural measures extracted using anisotropic, rotation-invariant GLCM statistics. The use of this index, applied in a moving window, has been shown to successfully identify built-up areas in remotely sensed imagery. Built-up index image masks are important input to the structuring of damage assessment interpretation because they help optimise the workload. The performance of computing the PANTEX workflow is compared on two different HPC hardware architectures: (1) a blade server with 4 blades, each having dual quad-core CPUs and (2) a CUDA enabled GPU workstation. The reference platform is a dual CPU-quad core workstation and the PANTEX workflow total computing time is measured. Furthermore, as part of a qualitative evaluation, the differences in setting up and configuring various hardware solutions and the related software coding effort is presented.

  8. Preparation of a criticality benchmark based on experiments performed at the RA-6 reactor

    International Nuclear Information System (INIS)

    Bazzana, S.; Blaumann, H; Marquez Damian, J.I

    2009-01-01

    The operation and fuel management of a reactor uses neutronic modeling to predict its behavior in operational and accidental conditions. This modeling uses computational tools and nuclear data that must be contrasted against benchmark experiments to ensure its accuracy. These benchmarks have to be simple enough to be possible to model with the desired computer code and have quantified and bound uncertainties. The start-up of the RA-6 reactor, final stage of the conversion and renewal project, allowed us to obtain experimental results with fresh fuel. In this condition the material composition of the fuel elements is precisely known, which contributes to a more precise modeling of the critical condition. These experimental results are useful to evaluate the precision of the models used to design the core, based on U 3 Si 2 and cadmium wires as burnable poisons, for which no data was previously available. The analysis of this information can be used to validate models for the analysis of similar configurations, which is necessary to follow the operational history of the reactor and perform fuel management. The analysis of the results and the generation of the model were done following the methodology established by International Criticality Safety Benchmark Evaluation Project, which gathers and analyzes experimental data for critical systems. The results were very satisfactory resulting on a value for the multiplication factor of the model of 1.0000 ± 0.0044, and a calculated value of 0.9980 ± 0.0001 using MCNP 5 and ENDF/B-VI. The utilization of as-built dimensions and compositions, and the sensitivity analysis allowed us to review the design calculations and analyze their precision, accuracy and error compensation. [es

  9. Functional evaluation of peripheral nerve regeneration and target reinnervation in animal models: a critical overview.

    Science.gov (United States)

    Navarro, Xavier

    2016-02-01

    Peripheral nerve injuries usually lead to severe loss of motor, sensory and autonomic functions in the patients. Due to the complex requirements for adequate axonal regeneration, functional recovery is often poorly achieved. Experimental models are useful to investigate the mechanisms related to axonal regeneration and tissue reinnervation, and to test new therapeutic strategies to improve functional recovery. Therefore, objective and reliable evaluation methods should be applied for the assessment of regeneration and function restitution after nerve injury in animal models. This review gives an overview of the most useful methods to assess nerve regeneration, target reinnervation and recovery of complex sensory and motor functions, their values and limitations. The selection of methods has to be adequate to the main objective of the research study, either enhancement of axonal regeneration, improving regeneration and reinnervation of target organs by different types of nerve fibres, or increasing recovery of complex sensory and motor functions. It is generally recommended to use more than one functional method for each purpose, and also to perform morphological studies of the injured nerve and the reinnervated targets. © 2015 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

  10. Natural selection on thermal preference, critical thermal maxima and locomotor performance.

    Science.gov (United States)

    Gilbert, Anthony L; Miles, Donald B

    2017-08-16

    Climate change is resulting in a radical transformation of the thermal quality of habitats across the globe. Whereas species have altered their distributions to cope with changing environments, the evidence for adaptation in response to rising temperatures is limited. However, to determine the potential of adaptation in response to thermal variation, we need estimates of the magnitude and direction of natural selection on traits that are assumed to increase persistence in warmer environments. Most inferences regarding physiological adaptation are based on interspecific analyses, and those of selection on thermal traits are scarce. Here, we estimate natural selection on major thermal traits used to assess the vulnerability of ectothermic organisms to altered thermal niches. We detected significant directional selection favouring lizards with higher thermal preferences and faster sprint performance at their optimal temperature. Our analyses also revealed correlational selection between thermal preference and critical thermal maxima, where individuals that preferred warmer body temperatures with cooler critical thermal maxima were favoured by selection. Recent published estimates of heritability for thermal traits suggest that, in concert with the strong selective pressures we demonstrate here, evolutionary adaptation may promote long-term persistence of ectotherms in altered thermal environments. © 2017 The Author(s).

  11. High Endothelial Venules and Other Blood Vessels: Critical Regulators of Lymphoid Organ Development and Function

    Science.gov (United States)

    Ager, Ann

    2017-01-01

    The blood vasculature regulates both the development and function of secondary lymphoid organs by providing a portal for entry of hemopoietic cells. During the development of lymphoid organs in the embryo, blood vessels deliver lymphoid tissue inducer cells that initiate and sustain the development of lymphoid tissues. In adults, the blood vessels are structurally distinct from those in other organs due to the requirement for high levels of lymphocyte recruitment under non-inflammatory conditions. In lymph nodes (LNs) and Peyer’s patches, high endothelial venules (HEVs) especially adapted for lymphocyte trafficking form a spatially organized network of blood vessels, which controls both the type of lymphocyte and the site of entry into lymphoid tissues. Uniquely, HEVs express vascular addressins that regulate lymphocyte entry into lymphoid organs and are, therefore, critical to the function of lymphoid organs. Recent studies have demonstrated important roles for CD11c+ dendritic cells in the induction, as well as the maintenance, of vascular addressin expression and, therefore, the function of HEVs. Tertiary lymphoid organs (TLOs) are HEV containing LN-like structures that develop inside organized tissues undergoing chronic immune-mediated inflammation. In autoimmune lesions, the development of TLOs is thought to exacerbate disease. In cancerous tissues, the development of HEVs and TLOs is associated with improved patient outcomes in several cancers. Therefore, it is important to understand what drives the development of HEVs and TLOs and how these structures contribute to pathology. In several human diseases and experimental animal models of chronic inflammation, there are some similarities between the development and function of HEVs within LN and TLOs. This review will summarize current knowledge of how hemopoietic cells with lymphoid tissue-inducing, HEV-inducing, and HEV-maintaining properties are recruited from the bloodstream to induce the development and

  12. Methodological aspects of functional neuroimaging at high field strength: a critical review

    International Nuclear Information System (INIS)

    Scheef, L.; Landsberg, M.W.; Boecker, H.

    2007-01-01

    The last few years have proven that high field magnetic resonance imaging (MRI) is superior in nearly every way to conventional equipment up to 1.5 tesla (T). Following the global success of 3T-scanners in research institutes and medical practices, a new generation of MRI devices with field strengths of 7T and higher is now on the horizon. The introduction of ultra high fields has brought MRI technology closer to the physical limitations and increasingly greater costs are required to achieve this goal. This article provides a critical overview of the advantages and problems of functional neuroimaging using ultra high field strengths. This review is principally limited to T2*-based functional imaging techniques not dependent on contrast agents. The main issues include the significance of high field technology with respect to SNR, CNR, resolution, and sequences, as well as artifacts, noise exposure, and SAR. Of great relevance is the discussion of parallel imaging, which will presumably determine the further development of high and ultra high field strengths. Finally, the importance of high field strengths for functional neuroimaging is explained by selected publications. (orig.)

  13. Astrocyte lipid metabolism is critical for synapse development and function in vivo.

    Science.gov (United States)

    van Deijk, Anne-Lieke F; Camargo, Nutabi; Timmerman, Jaap; Heistek, Tim; Brouwers, Jos F; Mogavero, Floriana; Mansvelder, Huibert D; Smit, August B; Verheijen, Mark H G

    2017-04-01

    The brain is considered to be autonomous in lipid synthesis with astrocytes producing lipids far more efficiently than neurons. Accordingly, it is generally assumed that astrocyte-derived lipids are taken up by neurons to support synapse formation and function. Initial confirmation of this assumption has been obtained in cell cultures, but whether astrocyte-derived lipids support synapses in vivo is not known. Here, we address this issue and determined the role of astrocyte lipid metabolism in hippocampal synapse formation and function in vivo. Hippocampal protein expression for the sterol regulatory element-binding protein (SREBP) and its target gene fatty acid synthase (Fasn) was found in astrocytes but not in neurons. Diminishing SREBP activity in astrocytes using mice in which the SREBP cleavage-activating protein (SCAP) was deleted from GFAP-expressing cells resulted in decreased cholesterol and phospholipid secretion by astrocytes. Interestingly, SCAP mutant mice showed more immature synapses, lower presynaptic protein SNAP-25 levels as well as reduced numbers of synaptic vesicles, indicating impaired development of the presynaptic terminal. Accordingly, hippocampal short-term and long-term synaptic plasticity were defective in mutant mice. These findings establish a critical role for astrocyte lipid metabolism in presynaptic terminal development and function in vivo. GLIA 2017;65:670-682. © 2017 Wiley Periodicals, Inc.

  14. Cutting edge: A critical functional role for IL-23 in psoriasis.

    Science.gov (United States)

    Tonel, Giulia; Conrad, Curdin; Laggner, Ute; Di Meglio, Paola; Grys, Katarzyna; McClanahan, Terrill K; Blumenschein, Wendy M; Qin, Jian-Zhong; Xin, Hong; Oldham, Elizabeth; Kastelein, Robert; Nickoloff, Brian J; Nestle, Frank O

    2010-11-15

    Interleukin-23 is a key cytokine involved in the generation of Th17 effector cells. Clinical efficacy of an anti-p40 mAb blocking both IL-12 and IL-23 and disease association with single nucleotide polymorphisms in the IL23R gene raise the question of a functional role of IL-23 in psoriasis. In this study, we provide a comprehensive analysis of IL-23 and its receptor in psoriasis and demonstrate its functional importance in a disease-relevant model system. The expression of IL-23 and its receptor was increased in the tissues of patients with psoriasis. Injection of a mAb specifically neutralizing human IL-23 showed IL-23-dependent inhibition of psoriasis development comparable to the use of anti-TNF blockers in a clinically relevant xenotransplant mouse model of psoriasis. Together, our results identify a critical functional role for IL-23 in psoriasis and provide the rationale for new treatment strategies in chronic epithelial inflammatory disorders.

  15. Bike Desks in the Classroom: Energy Expenditure, Physical Health, Cognitive Performance, Brain Functioning, and Academic Performance.

    Science.gov (United States)

    Torbeyns, Tine; de Geus, Bas; Bailey, Stephen; Decroix, Lieselot; Van Cutsem, Jeroen; De Pauw, Kevin; Meeusen, Romain

    2017-06-01

    Physical activity is positively associated with physical health, cognitive performance, brain functioning and academic performance. The aim of this study is to investigate the influence of bike desks in the classroom on adolescents' energy expenditure, physical health, cognitive performance, brain functioning and academic performance. Forty-four adolescents were randomly assigned to control group (CG) or intervention group (IG). During 5 months, the IG used a bike desk for 4 class hours/week. Energy expenditure was measured during 6 consecutive days. Anthropometric parameters, aerobic fitness, academic performance, cognitive performance and brain functioning were assessed before (T0) and after (T1) the intervention. Energy expenditure of the IG was significantly higher during the class hours in which they used the bike desks relative to normal class hours. The CG had a significantly higher BMI at T1 relative to T0 while this was not significantly different for the IG. Aerobic fitness was significantly better in the IG at T1 relative to T0. No significant effects on academic performance cognitive performance and brain functioning were observed. As the implementation of bike desks in the classroom did not interfere with adolescents' academic performance, this can be seen as an effective means of reducing in-class sedentary time and improving adolescents' physical health.

  16. Comparative evaluation of maintenance performance using subsurvival functions

    DEFF Research Database (Denmark)

    Paulsen, J.L.; Cooke, R.; Nyman, R.

    1997-01-01

    Subsurvival functions are applied to operational data for the control rod drive systems of Nordic nuclear reactors to evaluate maintenance performance. Competing failure modes are preventive and corrective maintenance. Maintenance indicators are defined and evaluated for 8 plants. (C) 1997 Elsevier...

  17. Evaluation of frother performance in coal flotation: A critical review of existing methodologies

    Energy Technology Data Exchange (ETDEWEB)

    Bhattacharya, S.; Dey, S. [Indian School for Mines, Dhanbad (India). Dept. for Fuel & Mineral Engineering

    2008-07-01

    Separation efficiency in flotation depends, to a considerable extent, on the efficiency of the frother used. A successful frother must achieve a delicate balance between froth stability and non-persistency. Ideally, the frother is not supposed to influence the state of the surface of the coal and minerals. In practice, however, interaction does occur between the frother, other reagents, and solid surfaces. Various commercially available frothers can differ slightly or significantly in their influence on the flotation results. Therefore, a plant operator is in a dilemma when it comes to selecting a frother to be used in his plant. This article attempts to critically review the different methodologies, which are available to compare the performance of two or more frothers in order to decide which would best serve the purpose of the plant operator.

  18. Performance assessment of new neutron cross section libraries using MCNP code and some critical benchmarks

    International Nuclear Information System (INIS)

    Bakkari, B El; Bardouni, T El.; Erradi, L.; Chakir, E.; Meroun, O.; Azahra, M.; Boukhal, H.; Khoukhi, T El.; Htet, A.

    2007-01-01

    Full text: New releases of nuclear data files made available during the few recent years. The reference MCNP5 code (1) for Monte Carlo calculations is usually distributed with only one standard nuclear data library for neutron interactions based on ENDF/B-VI. The main goal of this work is to process new neutron cross sections libraries in ACE continuous format for MCNP code based on the most recent data files recently made available for the scientific community : ENDF/B-VII.b2, ENDF/B-VI (release 8), JEFF3.0, JEFF-3.1, JENDL-3.3 and JEF2.2. In our data treatment, we used the modular NJOY system (release 99.9) (2) in conjunction with its most recent upadates. Assessment of the processed point wise cross sections libraries performances was made by means of some criticality prediction and analysis of other integral parameters for a set of reactor benchmarks. Almost all the analyzed benchmarks were taken from the international handbook of Evaluated criticality safety benchmarks experiments from OECD (3). Some revised benchmarks were taken from references (4,5). These benchmarks use Pu-239 or U-235 as the main fissionable materiel in different forms, different enrichments and cover various geometries. Monte Carlo calculations were performed in 3D with maximum details of benchmark description and the S(α,β) cross section treatment was adopted in all thermal cases. The resulting one standard deviation confidence interval for the eigenvalue is typically +/-13% to +/-20 pcm [fr

  19. Human performance in nondestructive inspections and functional tests: Final report

    International Nuclear Information System (INIS)

    Harris, D.H.

    1988-10-01

    Human performance plays a vital role in the inspections and tests conducted to assure the physical integrity of nuclear power plants. Even when technically-sophisticated equipment is employed, the outcome is highly dependent on human control actions, calibrations, observations, analyses, and interpretations. The principal consequences of inadequate performance are missed or falsely-reported defects. However, the cost-avoidance that stems from addressing potential risks promptly, and the increasing costs likely with aging plants, emphasize that timeliness and efficiency are important inspection-performance considerations also. Human performance issues were studied in a sample of inspections and tests regularly conducted in nuclear power plants. These tasks, selected by an industry advisory panel, were: eddy-current inspection of steam-generator tubes; ultrasonic inspection of pipe welds; inservice testing of pumps and valves; and functional testing of shock suppressors. Information was obtained for the study from industry and plant procedural documents; training materials; research reports and related documents; interviews with training specialists, inspectors, supervisory personnel, and equipment designers; and first-hand observations of task performance. Eleven recommendations are developed for improving human performance on nondestructive inspections and functional tests. Two recommendations were for the more-effective application of existing knowledge; nine recommendations were for research projects that should be undertaken to assure continuing improvements in human performance on these tasks. 25 refs., 9 figs., 1 tab

  20. Evaluation of the diagnostic accuracy of ultra-miniaturized pocket ultrasound device on cardiac function in critically ill patients

    Directory of Open Access Journals (Sweden)

    Li WANG

    2016-09-01

    Full Text Available Objective  To compare the diagnostic accuracy of a new ultra-miniaturized pocket ultrasound device (PUD (VscanTM, GE Healthcare, Wauwatosa, WI and conventional high-quality echocardiography system (Vivid qTM, GE Healthcare for a cardiac focused ultrasonography in critical patients. Methods  The patients admitted to our hospital and receiving transthoracic echocardiography (TTE using a PUD and a conventional echocardiography system were included in this study during the 10 months from December 2013 to October 2014. Each examination was performed independently by an intensive care unit (ICU physician and an experienced ultrasound doctor, unaware of the results found by the alternative device. The following parameters were assessed: global cardiac systolic function, identification of ventricular size, whether or not accompanying enlargement or hypertrophy, assessment for the morphology of cardiac valves and its function, pericardial effusion and estimation of the inferior vena cava (IVC diameter. The time-consuming of each device were recorded. Results  One hundred and twenty-eight patients were included in the study. Their left ventricular wall motion abnormalities, global left ventricular systolic dysfunction, pericardial effusion, IVC dilation were assessed by PUD and the assessment results were highly consistent with those by Vivid q (κ>0.84. The consistency was slightly lower in evaluating the left and right ventricular size. For evaluating the cardiac valves function, the agreement of two devices were relatively low (κ=0.69-0.84. Compared with Vivid q, PUD took less time (4.7±1.4min vs 6.3±2.6min; P<0.05. Conclusion  PUD can provide fast, reliable cardiac examination, thus being an effective method for ICU physicians to assess the cardiac f unction in critical patients. DOI: 10.11855/j.issn.0577-7402.2016.08.10

  1. Adenosine A1 receptors (A1Rs) play a critical role in osteoclast formation and function

    Science.gov (United States)

    Kara, Firas M.; Chitu, Violeta; Sloane, Jennifer; Axelrod, Matthew; Fredholm, Bertil B.; Stanley, E. Richard; Cronstein, Bruce N.

    2010-01-01

    Adenosine regulates a wide variety of physiological processes via interaction with one or more G-protein-coupled receptors (A1R, A2AR, A2BR, and A3R). Because A1R occupancy promotes fusion of human monocytes to form giant cells in vitro, we determined whether A1R occupancy similarly promotes osteoclast function and formation. Bone marrow cells (BMCs) were harvested from C57Bl/6 female mice or A1R-knockout mice and their wild-type (WT) littermates and differentiated into osteoclasts in the presence of colony stimulating factor-1 and receptor activator of NF-κB ligand in the presence or absence of the A1R antagonist 1,3-dipropyl-8-cyclopentyl xanthine (DPCPX). Osteoclast morphology was analyzed in tartrate-resistant acid phosphatase or F-actin-stained samples, and bone resorption was evaluated by toluidine blue staining of dentin. BMCs from A1R-knockout mice form fewer osteoclasts than BMCs from WT mice, and the A1R antagonist DPCPX inhibits osteoclast formation (IC50=1 nM), with altered morphology and reduced ability to resorb bone. A1R blockade increased ubiquitination and degradation of TRAF6 in RAW264.7 cells induced to differentiate into osteoclasts. These studies suggest a critical role for adenosine in bone homeostasis via interaction with adenosine A1R and further suggest that A1R may be a novel pharmacologic target to prevent the bone loss associated with inflammatory diseases and menopause.—Kara, F. M., Chitu, V., Sloane, J., Axelrod, M., Fredholm, B. B., Stanley, R., Cronstein, B. N. Adenosine A1 receptors (A1Rs) play a critical role in osteoclast formation and function. PMID:20181934

  2. Functional Movement Screening and Paddle-Sport Performance

    Directory of Open Access Journals (Sweden)

    Andrew Hatchett

    2017-06-01

    Full Text Available The purpose of the study reported here was to determine the relationship between an endurance paddle-sport athlete’s total functional movement screening (FMS score and individual race performance. Fifty elite level endurance canoeists and kayakers completed the seven-stage FMS protocol prior to the 2016 United States Canoe and Kayak Association National Championship race. Time taken to finish the race was then associated to overall FMS score and respective sub-scores. Total FMS score and various sub-scores were significantly related to race performance. Female and male athletes differed in which sub-scores were shown to be significantly correlated to finishing time. Outcomes from this study indicate that limitations in functional movement are related to endurance paddle-sport race performance.

  3. Improved Functional Performance in Geriatric Patients During Hospital Stay

    DEFF Research Database (Denmark)

    Karlsen, Anders; Loeb, Mads Rohde; Andersen, Kristine Bramsen

    2017-01-01

    OBJECTIVE: The aim of this work was to evaluate the time course of changes in strength and functional performance in elderly hospitalized medical patients. DESIGN: This was a prospective observational study in elderly medical patients of age 65 years or older at a geriatric department.Measurement......OBJECTIVE: The aim of this work was to evaluate the time course of changes in strength and functional performance in elderly hospitalized medical patients. DESIGN: This was a prospective observational study in elderly medical patients of age 65 years or older at a geriatric department.......Measurements were obtained on days 2 to 4, day 5 to 8, and days 9 to 13. Functional performance was measured with De Morton Mobility Index (DEMMI) test and a 30-second chair stand test (30-s CST). Muscular strength was measured with handgrip strength. Activity level was determined with accelerometry (Activ...... in 30-s CST (P performance of the lower extremities in geriatric patients improves moderately over the time of a hospital stay...

  4. Robust design principles for reducing variation in functional performance

    DEFF Research Database (Denmark)

    Christensen, Martin Ebro; Howard, Thomas J.

    2016-01-01

    This paper identifies, describes and classifies a comprehensive collection of variation reduction principles (VRP) that can be used to increase the robustness of a product and reduce its variation in functional performance. Performance variation has a negative effect on the reliability and percei......This paper identifies, describes and classifies a comprehensive collection of variation reduction principles (VRP) that can be used to increase the robustness of a product and reduce its variation in functional performance. Performance variation has a negative effect on the reliability...... and perceived quality of a product and efforts should be made to minimise it. The design principles are identified by a systematic decomposition of the Taguchi Transfer Function in combination with the use of existing literature and the authors’ experience. The paper presents 15 principles and describes...... their advantages and disadvantages along with example cases. Subsequently, the principles are classified based on their applicability in the various development and production stages. The VRP are to be added to existing robust design methodologies, helping the designer to think beyond robust design tool and method...

  5. Characterization of tetratricopeptide repeat-containing proteins critical for cilia formation and function.

    Directory of Open Access Journals (Sweden)

    Yanan Xu

    Full Text Available Cilia formation and function require a special set of trafficking machinery termed intraflagellar transport (IFT, consisting mainly of protein complexes IFT-A, IFT-B, BBSome, and microtubule-dependent molecular motors. Tetratricopeptide repeat-containing (TTC proteins are widely involved in protein complex formation. Nine of them are known to serve as components of the IFT or BBSome complexes. How many TTC proteins are cilia-related and how they function, however, remain unclear. Here we show that twenty TTC genes were upregulated by at least 2-fold during the differentiation of cultured mouse tracheal epithelial cells (MTECs into multiciliated cells. Our systematic screen in zebrafish identified four novel TTC genes, ttc4, -9c, -36, and -39c, that are critical for cilia formation and motility. Accordingly, their zebrafish morphants displayed typical ciliopathy-related phenotypes, including curved body, abnormal otolith, hydrocephalus, and defective left-right patterning. The morphants of ttc4 and ttc25, a known cilia-related gene, additionally showed pronephric cyst formation. Immunoprecipitation indicated associations of TTC4, -9c, -25, -36, and -39c with components or entire complexes of IFT-A, IFT-B, or BBSome, implying their participations in IFT or IFT-related activities. Our results provide a global view for the relationship between TTC proteins and cilia.

  6. HSI for monitoring the critical safety functions status tree of a NPP

    International Nuclear Information System (INIS)

    Oliveira, Mauro Vitor de; Almeida, Jose Carlos Soares de; Augusto, Silas Cordeiro; Jaime, Guilherme Dutra Gonzaga

    2013-01-01

    Critical safety function (CSF) is the most significant design concept for prioritize operator actions based on the potential threat to the three barriers (fuel cladding, primary coolant system boundary, and containment) and allows the operator to respond to these threats prior to event diagnosis. CSF has a hierarchical information structure that organizes the system variables affecting the plant safety in terms of goal-means relations. It is important that the operator should be aware of various success paths associated with each CSF in order to respond to unanticipated system failures quickly. When an emergency occurs in NPPs, the operator should monitor CSFs periodically and identify possible success paths as necessary, and try to stabilize or safely shut down the plant using emergency operating procedure (EOP) that includes steps to check the CSFs. This implies that safety function status check may become a cognitively burdensome task that needs to be supported by proper information display. The advanced human-system interface (HSI) in nuclear power plants provides an information environment that supports the operators' burdensome cognitive tasks. This paper describes a CSFs interface design for supporting the operator's tasks to monitor and identify the associated success path for Westinghouse 3-loops NPP. (author)

  7. Snapin-regulated late endosomal transport is critical for efficient autophagy-lysosomal function in neurons.

    Science.gov (United States)

    Cai, Qian; Lu, Li; Tian, Jin-Hua; Zhu, Yi-Bing; Qiao, Haifa; Sheng, Zu-Hang

    2010-10-06

    Neuron maintenance and survival require late endocytic transport from distal processes to the soma where lysosomes are predominantly localized. Here, we report a role for Snapin in attaching dynein to late endosomes through its intermediate chain (DIC). snapin(-/-) neurons exhibit aberrant accumulation of immature lysosomes, clustering and impaired retrograde transport of late endosomes along processes, reduced lysosomal proteolysis due to impaired delivery of internalized proteins and hydrolase precursors from late endosomes to lysosomes, and impaired clearance of autolysosomes, combined with reduced neuron viability and neurodegeneration. The phenotypes are rescued by expressing the snapin transgene, but not the DIC-binding-defective Snapin-L99K mutant. Snapin overexpression in wild-type neurons enhances late endocytic transport and lysosomal function, whereas expressing the mutant defective in Snapin-DIC coupling shows a dominant-negative effect. Altogether, our study highlights new mechanistic insights into how Snapin-DIC coordinates retrograde transport and late endosomal-lysosomal trafficking critical for autophagy-lysosomal function, and thus neuronal homeostasis. Copyright © 2010 Elsevier Inc. All rights reserved.

  8. The critical role of catalase in prooxidant and antioxidant function of p53

    Science.gov (United States)

    Kang, M Y; Kim, H-B; Piao, C; Lee, K H; Hyun, J W; Chang, I-Y; You, H J

    2013-01-01

    The tumor suppressor p53 is an important regulator of intracellular reactive oxygen species (ROS) levels, although downstream mediators of p53 remain to be elucidated. Here, we show that p53 and its downstream targets, p53-inducible ribonucleotide reductase (p53R2) and p53-inducible gene 3 (PIG3), physically and functionally interact with catalase for efficient regulation of intracellular ROS, depending on stress intensity. Under physiological conditions, the antioxidant functions of p53 are mediated by p53R2, which maintains increased catalase activity and thereby protects against endogenous ROS. After genotoxic stress, high levels of p53 and PIG3 cooperate to inhibit catalase activity, leading to a shift in the oxidant/antioxidant balance toward an oxidative status, which could augment apoptotic cell death. These results highlight the essential role of catalase in p53-mediated ROS regulation and suggest that the p53/p53R2–catalase and p53/PIG3–catalase pathways are critically involved in intracellular ROS regulation under physiological conditions and during the response to DNA damage, respectively. PMID:22918438

  9. Enhancing Functional Performance using Sensorimotor Adaptability Training Programs

    Science.gov (United States)

    Bloomberg, J. J.; Mulavara, A. P.; Peters, B. T.; Brady, R.; Audas, C.; Ruttley, T. M.; Cohen, H. S.

    2009-01-01

    During the acute phase of adaptation to novel gravitational environments, sensorimotor disturbances have the potential to disrupt the ability of astronauts to perform functional tasks. The goal of this project is to develop a sensorimotor adaptability (SA) training program designed to facilitate recovery of functional capabilities when astronauts transition to different gravitational environments. The project conducted a series of studies that investigated the efficacy of treadmill training combined with a variety of sensory challenges designed to increase adaptability including alterations in visual flow, body loading, and support surface stability.

  10. A New Approach of Modeling an Ultra-Super-Critical Power Plant for Performance Improvement

    Directory of Open Access Journals (Sweden)

    Guolian Hou

    2016-04-01

    Full Text Available A suitable model of coordinated control system (CCS with high accuracy and simple structure is essential for the design of advanced controllers which can improve the efficiency of the ultra-super-critical (USC power plant. Therefore, with the demand of plant performance improvement, an improved T-S fuzzy model identification approach is proposed in this paper. Firstly, the improved entropy cluster algorithm is applied to identify the premise parameters which can automatically determine the cluster numbers and initial cluster centers by introducing the concept of a decision-making constant and threshold. Then, the learning algorithm is used to modify the initial cluster center and a new structure of concluding part is discussed, the incremental data around the cluster center is used to identify the local linear model through a weighted recursive least-square algorithm. Finally, the proposed approach is employed to model the CCS of a 1000 MW USC one-through boiler power plant by using on-site measured data. Simulation results show that the T-S fuzzy model built in this paper is accurate enough to reflect the dynamic performance of CCS and can be treated as a foundation model for the overall optimizing control of the USC power plant.

  11. Critical care nurses' experiences of performing successful peripheral intravenous catheterization in difficult situations.

    Science.gov (United States)

    Forsberg, Angelica; Engström, Åsa

    2018-06-01

    The aim of this study is to describe the experiences of critical care nurses (CCNs) when performing successful peripheral intravenous catheterization (PIVC) on adult inpatients in difficult situations. This study uses a descriptive design with a qualitative approach. Semistructured interviews were given to CCNs (n = 22) at a general central county hospital in northern Sweden. The interview text was analyzed with qualitative thematic content analysis. Three themes emerged: "releasing time and creating peace," "feeling self-confidence in the role of expert nurse," and "technical interventions promoting success." CCNs stated that apart from experience, releasing enough time is the most crucial factor for a successful PIVC. They emphasized the importance of identifying the kinds of difficulties that may occur during the procedure, for example, fragile or/and invisible veins. CCNs explained that compared to when they were newly graduated, the difference in their approach nowadays has changed to using their hands more than their eyes and that they feel comfortable with bodily palpations. To further optimize PIVC performing skills, continued possibilities to train and learn in hospital settings are necessary, even after formal education has been completed. Copyright © 2018 Society for Vascular Nursing, Inc. Published by Elsevier Inc. All rights reserved.

  12. Critical research issues in development of biomathematical models of fatigue and performance.

    Science.gov (United States)

    Dinges, David F

    2004-03-01

    This article reviews the scientific research needed to ensure the continued development, validation, and operational transition of biomathematical models of fatigue and performance. These models originated from the need to ascertain the formal underlying relationships among sleep and circadian dynamics in the control of alertness and neurobehavioral performance capability. Priority should be given to research that further establishes their basic validity, including the accuracy of the core mathematical formulae and parameters that instantiate the interactions of sleep/wake and circadian processes. Since individuals can differ markedly and reliably in their responses to sleep loss and to countermeasures for it, models must incorporate estimates of these inter-individual differences, and research should identify predictors of them. To ensure models accurately predict recovery of function with sleep of varying durations, dose-response curves for recovery of performance as a function of prior sleep homeostatic load and the number of days of recovery are needed. It is also necessary to establish whether the accuracy of models is affected by using work/rest schedules as surrogates for sleep/wake inputs to models. Given the importance of light as both a circadian entraining agent and an alerting agent, research should determine the extent to which light input could incrementally improve model predictions of performance, especially in persons exposed to night work, jet lag, and prolonged work. Models seek to estimate behavioral capability and/or the relative risk of adverse events in a fatigued state. Research is needed on how best to scale and interpret metrics of behavioral capability, and incorporate factors that amplify or diminish the relationship between model predictions of performance and risk outcomes.

  13. Scholastic performance and functional connectivity of brain networks in children.

    Directory of Open Access Journals (Sweden)

    Laura Chaddock-Heyman

    Full Text Available One of the keys to understanding scholastic success is to determine the neural processes involved in school performance. The present study is the first to use a whole-brain connectivity approach to explore whether functional connectivity of resting state brain networks is associated with scholastic performance in seventy-four 7- to 9-year-old children. We demonstrate that children with higher scholastic performance across reading, math and language have more integrated and interconnected resting state networks, specifically the default mode network, salience network, and frontoparietal network. To add specificity, core regions of the dorsal attention and visual networks did not relate to scholastic performance. The results extend the cognitive role of brain networks in children as well as suggest the importance of network connectivity in scholastic success.

  14. Critical heat flux prediction by using radial basis function and multilayer perceptron neural networks: A comparison study

    International Nuclear Information System (INIS)

    Vaziri, Nima; Hojabri, Alireza; Erfani, Ali; Monsefi, Mehrdad; Nilforooshan, Behnam

    2007-01-01

    Critical heat flux (CHF) is an important parameter for the design of nuclear reactors. Although many experimental and theoretical researches have been performed, there is not a single correlation to predict CHF because it is influenced by many parameters. These parameters are based on fixed inlet, local and fixed outlet conditions. Artificial neural networks (ANNs) have been applied to a wide variety of different areas such as prediction, approximation, modeling and classification. In this study, two types of neural networks, radial basis function (RBF) and multilayer perceptron (MLP), are trained with the experimental CHF data and their performances are compared. RBF predicts CHF with root mean square (RMS) errors of 0.24%, 7.9%, 0.16% and MLP predicts CHF with RMS errors of 1.29%, 8.31% and 2.71%, in fixed inlet conditions, local conditions and fixed outlet conditions, respectively. The results show that neural networks with RBF structure have superior performance in CHF data prediction over MLP neural networks. The parametric trends of CHF obtained by the trained ANNs are also evaluated and results reported

  15. Critical analysis of the literature investigating urogenital function preservation following robotic rectal cancer surgery

    Institute of Scientific and Technical Information of China (English)

    Sofoklis; Panteleimonitis; Jamil; Ahmed; Mick; Harper; Amjad; Parvaiz

    2016-01-01

    AIM To analyses the current literature regarding the urogenital functional outcomes of patients receiving robotic rectal cancer surgery. METHODS A comprehensive literature search of electronic databases was performed in October 2015. The following search terms were applied: 'rectal cancer' or 'colorectal cancer' and robot* or 'da Vinci' and sexual or urolog* or urinary or erect* or ejaculat* or impot* or incontinence. All original studies examining the urological and/or sexual outcomes of male and/or female patients receiving robotic rectal cancer surgery were included. Reference lists of all retrieved articles were manually searched for further relevant articles. Abstracts were independently searched by two authors. RESULTS Fifteen original studies fulfilled the inclusion criteria. A total of 1338 patients were included; 818 received robotic, 498 laparoscopic and 22 open rectal cancer surgery. Only 726(54%) patients had their urogenital function assessed via means of validated functional questionnaires. From the included studies, three found that robotic rectal cancer surgery leads to quicker recovery of male urological function and five of male sexual function as compared to laparoscopic surgery. It is unclear whether robotic surgery offers favourable urogenital outcomes in the long run for males. In female patients only two studies assessed urological and threesexual function independently to that of males. In these studies there was no difference identified between patients receiving robotic and laparoscopic rectal cancer surgery. However, in females the presented evidence was very limited making it impossible to draw any substantial conclusions. CONCLUSION There seems to be a trend towards earlier recovery of male urogenital function following robotic surgery. To evaluate this further, larger well designed studies are required.

  16. Critical analysis of the literature investigating urogenital function preservation following robotic rectal cancer surgery

    Institute of Scientific and Technical Information of China (English)

    Sofoklis; Panteleimonitis[1,2; Jamil; Ahmed[1; Mick; Harper[2; Amjad; Parvaiz[1,2

    2016-01-01

    AIM To analyses the current literature regarding the urogenital functional outcomes of patients receiving robotic rectal cancer surgery.METHODS A comprehensive literature search of electronic databases was performed in October 2015. The following search terms were applied: “rectal cancer” or “colorectal cancer” and robot* or “da Vinci” and sexual or urolog* or urinary or erect* or ejaculat* or impot* or incontinence.All original studies examining the urological and/or sexual outcomes of male and/or female patients receiving robotic rectal cancer surgery were included. Reference lists of all retrieved articles were manually searched for further relevant articles. Abstracts were independently searched by two authors.RESULTS Fifteen original studies fulfilled the inclusion criteria.A total of 1338 patients were included; 818 received robotic, 498 laparoscopic and 22 open rectal cancer surgery. Only 726 (54%) patients had their urogenital function assessed via means of validated functional questionnaires. From the included studies, three found that robotic rectal cancer surgery leads to quicker recovery of male urological function and five of male sexual function as compared to laparoscopic surgery.It is unclear whether robotic surgery offers favourable urogenital outcomes in the long run for males. In female patients only two studies assessed urological and three sexual function independently to that of males. In these studies there was no difference identified between patients receiving robotic and laparoscopic rectal cancer surgery. However, in females the presented evidence was very limited making it impossible to draw any substantial conclusions.CONCLUSION There seems to be a trend towards earlier recovery of male urogenital function following robotic surgery. To evaluate this further, larger well designed studies are required.

  17. Sensitivity functions for uncertainty analysis: Sensitivity and uncertainty analysis of reactor performance parameters

    International Nuclear Information System (INIS)

    Greenspan, E.

    1982-01-01

    This chapter presents the mathematical basis for sensitivity functions, discusses their physical meaning and information they contain, and clarifies a number of issues concerning their application, including the definition of group sensitivities, the selection of sensitivity functions to be included in the analysis, and limitations of sensitivity theory. Examines the theoretical foundation; criticality reset sensitivities; group sensitivities and uncertainties; selection of sensitivities included in the analysis; and other uses and limitations of sensitivity functions. Gives the theoretical formulation of sensitivity functions pertaining to ''as-built'' designs for performance parameters of the form of ratios of linear flux functionals (such as reaction-rate ratios), linear adjoint functionals, bilinear functions (such as reactivity worth ratios), and for reactor reactivity. Offers a consistent procedure for reducing energy-dependent or fine-group sensitivities and uncertainties to broad group sensitivities and uncertainties. Provides illustrations of sensitivity functions as well as references to available compilations of such functions and of total sensitivities. Indicates limitations of sensitivity theory originating from the fact that this theory is based on a first-order perturbation theory

  18. A conserved cysteine motif is critical for rice ceramide kinase activity and function.

    Directory of Open Access Journals (Sweden)

    Fang-Cheng Bi

    Full Text Available Ceramide kinase (CERK is a key regulator of cell survival in dicotyledonous plants and animals. Much less is known about the roles of CERK and ceramides in mediating cellular processes in monocot plants. Here, we report the characterization of a ceramide kinase, OsCERK, from rice (Oryza sativa spp. Japonica cv. Nipponbare and investigate the effects of ceramides on rice cell viability.OsCERK can complement the Arabidopsis CERK mutant acd5. Recombinant OsCERK has ceramide kinase activity with Michaelis-Menten kinetics and optimal activity at 7.0 pH and 40°C. Mg2+ activates OsCERK in a concentration-dependent manner. Importantly, a CXXXCXXC motif, conserved in all ceramide kinases and important for the activity of the human enzyme, is critical for OsCERK enzyme activity and in planta function. In a rice protoplast system, inhibition of CERK leads to cell death and the ratio of added ceramide and ceramide-1-phosphate, CERK's substrate and product, respectively, influences cell survival. Ceramide-induced rice cell death has apoptotic features and is an active process that requires both de novo protein synthesis and phosphorylation, respectively. Finally, mitochondria membrane potential loss previously associated with ceramide-induced cell death in Arabidopsis was also found in rice, but it occurred with different timing.OsCERK is a bona fide ceramide kinase with a functionally and evolutionarily conserved Cys-rich motif that plays an important role in modulating cell fate in plants. The vital function of the conserved motif in both human and rice CERKs suggests that the biochemical mechanism of CERKs is similar in animals and plants. Furthermore, ceramides induce cell death with similar features in monocot and dicot plants.

  19. Generalized partition function zeros of 1D spin models and their critical behavior at edge singularities

    International Nuclear Information System (INIS)

    Dalmazi, D; Sa, F L

    2010-01-01

    Here we study the partition function zeros of the one-dimensional Blume-Emery-Griffiths model close to their edge singularities. The model contains four couplings (H, J, Δ, K) including the magnetic field H and the Ising coupling J. We assume that only one of the three couplings (J, Δ, K) is complex and the magnetic field is real. The generalized zeros z i tend to form continuous curves on the complex z-plane in the thermodynamic limit. The linear density at the edges z E diverges usually with ρ(z) ∼ |z - z E | σ and σ = -1/2. However, as in the case of complex magnetic fields (Yang-Lee edge singularity), if we have a triple degeneracy of the transfer matrix eigenvalues a new critical behavior with σ = -2/3 can appear as we prove here explicitly for the cases where either Δ or K is complex. Our proof applies for a general three-state spin model with short-range interactions. The Fisher zeros (complex J) are more involved; in practice, we have not been able to find an explicit example with σ = -2/3 as far as the other couplings (H, Δ, K) are kept as real numbers. Our results are supported by numerical computations of zeros. We show that it is absolutely necessary to have a non-vanishing magnetic field for a new critical behavior. The appearance of σ = -2/3 at the edge closest to the positive real axis indicates its possible relevance for tricritical phenomena in higher-dimensional spin models.

  20. Treadmill Exercise with Increased Body Loading Enhances Post Flight Functional Performance

    Science.gov (United States)

    Bloomberg, J. J.; Batson, C. D.; Buxton, R. E.; Feiveson, A. H.; Kofman, I. S.; Laurie, S.; Lee, S. M. C.; Miller, C. A.; Mulavara, A. P.; Peters, B. T.; hide

    2014-01-01

    -support loading experienced during inflight treadmill exercise impacts postflight functional performance, the loading history for each subject during inflight treadmill (T2) exercise was correlated with postflight measures of performance. Crewmembers who walked on the treadmill with higher pull-down loads had less decrement in postflight postural stability and dynamic locomotor control than those subjects who exercised with lighter loads. These data point to the importance of providing significant body loading during inflight treadmill exercise. This and the addition of specific balance training may further mitigate decrements in critical mission tasks that require dynamic postural stability and mobility. Inflight treadmill exercise provides a multi-disciplinary platform to provide sensorimotor, aerobic and bone mechanical stimuli benefits. Forward work will focus on the development of an inflight training system that will integrate aerobic, resistive and balance training modalities into a single interdisciplinary countermeasure system for exploration class missions.

  1. Water Quality Improvement Performance of Geotextiles Within Permeable Pavement Systems: A Critical Review

    Directory of Open Access Journals (Sweden)

    Miklas Scholz

    2013-04-01

    Full Text Available Sustainable drainage systems (SuDS; or best management practices are increasingly being used as ecological engineering techniques to prevent the contamination of receiving watercourses and groundwater. Permeable paving is a SuDS technique, which is commonplace in car parks, driveways and minor roads where one of their functions is to improve the quality of urban runoff. However, little is known about the water quality benefits of incorporating an upper geotextile within the paving structure. The review focuses on five different categories of pollutants: organic matter, nutrients, heavy metals, motor oils, suspended solids originating from street dust, and chloride. The paper critically assesses results from previous international tests and draws conclusions on the scientific rigour and significance of the data. Findings indicate that only very few studies have been undertaken to address the role of geotextiles directly. All indications are that the presence of a geotextile leads only to minor water quality improvements. For example, suspended solids are being held back by the geotextile and these solids sometimes contain organic matter, nutrients and heavy metals. However, most studies were inconclusive and data were often unsuitable for further statistical analysis. Further long-term research on industry-relevant, and statistically and scientifically sound, experimental set-ups is recommended.

  2. Kinesiophobia, Pain, Muscle Functions, and Functional Performances among Older Persons with Low Back Pain

    Directory of Open Access Journals (Sweden)

    Nor Azizah Ishak

    2017-01-01

    Full Text Available Objectives. This study aims (1 to determine the association between kinesiophobia and pain, muscle functions, and functional performances and (2 to determine whether kinesiophobia predicts pain, muscle functions, and functional performance among older persons with low back pain (LBP. Methods. This is a correlational study, involving 63 institutionalized older persons (age = 70.98±7.90 years diagnosed with LBP. Anthropometric characteristics (BMI and functional performances (lower limb function, balance and mobility, and hand grip strength were measured. Muscle strength (abdominal and back muscle strength was assessed using the Baseline® Mechanical Push/Pull Dynamometer, while muscle control (transverse abdominus and multifidus was measured by using the Pressure Biofeedback Unit. The pain intensity and the level of kinesiophobia were measured using Numerical Rating Scale and Tampa Scale of Kinesiophobia, respectively. Data were analyzed using Pearson’s correlation coefficients and multivariate linear regressions. Results. No significant correlations were found between kinesiophobia and pain and muscle functions (all p>0.05. Kinesiophobia was significantly correlated with mobility and balance (p=0.038, r=0.263. Regressions analysis showed that kinesiophobia was a significant predictor of mobility and balance (p=0.038. Conclusion. We can conclude that kinesiophobia predicted mobility and balance in older persons with LBP. Kinesiophobia should be continuously assessed in clinical settings to recognize the obstacles that may affect patient’s compliance towards a rehabilitation program in older persons with LBP.

  3. Normative Functional Performance Values in High School Athletes: The Functional Pre-Participation Evaluation Project.

    Science.gov (United States)

    Onate, James A; Starkel, Cambrie; Clifton, Daniel R; Best, Thomas M; Borchers, James; Chaudhari, Ajit; Comstock, R Dawn; Cortes, Nelson; Grooms, Dustin R; Hertel, Jay; Hewett, Timothy E; Miller, Meghan Maume; Pan, Xueliang; Schussler, Eric; Van Lunen, Bonnie L

    2018-01-01

      The fourth edition of the Preparticipation Physical Evaluation recommends functional testing for the musculoskeletal portion of the examination; however, normative data across sex and grade level are limited. Establishing normative data can provide clinicians reference points with which to compare their patients, potentially aiding in the development of future injury-risk assessments and injury-mitigation programs.   To establish normative functional performance and limb-symmetry data for high school-aged male and female athletes in the United States.   Cross-sectional study.   Athletic training facilities and gymnasiums across the United States.   A total of 3951 male and female athletes who participated on high school-sponsored basketball, football, lacrosse, or soccer teams enrolled in this nationwide study.   Functional performance testing consisted of 3 evaluations. Ankle-joint range of motion, balance, and lower extremity muscular power and landing control were assessed via the weight-bearing ankle-dorsiflexion-lunge, single-legged anterior-reach, and anterior single-legged hop-for-distance (SLHOP) tests, respectively. We used 2-way analyses of variance and χ 2 analyses to examine the effects of sex and grade level on ankle-dorsiflexion-lunge, single-legged anterior-reach, and SLHOP test performance and symmetry.   The SLHOP performance differed between sexes (males = 187.8% ± 33.1% of limb length, females = 157.5% ± 27.8% of limb length; t = 30.3, P performance. We observed differences for SLHOP and ankle-dorsiflexion-lunge performance among grade levels, but these differences were not clinically meaningful.   We demonstrated differences in normative data for lower extremity functional performance during preparticipation physical evaluations across sex and grade levels. The results of this study will allow clinicians to compare sex- and grade-specific functional performances and implement approaches for preventing musculoskeletal

  4. Study on functional relationships between ergonomics indexes of manual performance

    Science.gov (United States)

    Hu, Hui-Min; Ding, Li; Chen, Shou-Ping; Yang, Chun-Xin; Yuan, Xiu-Gan

    This paper investigates functional relationships between some of the key ergonomics indexes in manual performance, and attempts to condense the ergonomics appraisal indexes system and thus evaluate hand performance wearing EVA (extravehicular activity) glove, design and improve EVA glove's performance. Four types of ergonomics indexes were studied, i.e., dexterity, tactile sensibility (TS), strength and fatigue. Two test items of insert sticks into a holes-board (ISIHB) and nuts-bolts assembly task (NBAT) were used to measure dexterity, while shape discrimination (SD) was employed for TS, and grip force (GF) for strength and fatigue. The variables measured in this investigation included accomplishing time (AT) of ISIHB and NBAT, correct rate (CR) of SD, maximal grip force (MGF), instant grip force (IGF) and endurance time of grip force (ETGF). Experiments were conducted on 31 undergraduates (eight female and 23 male) with two experiment conditions of bare-hand group and gloved hand group. Results demonstrated that dexterity and TS performance of gloved hand group declined significantly compared with those of bare-hand group (pfatigue between two conditions (p>0.05). Four effective functional relationships were developed between four pairs of ergonomics indexes in bare-hand group. In gloved hand group, in addition to above-mentioned four pairs of relationships, another formula was found, which was y^=0.02061+0.01233x ( p<0.01, dexterity and TS).

  5. Criticality Experiments Performed in Saclay and Valduc Centers, France (1958-2002)

    International Nuclear Information System (INIS)

    Barbry, F.; Grivot, P.; Girault, E.; Fouillaud, P.; Cousinou, P.; Poullot, G.; Anno, J.; Bordy, J.M.; Doutriaux, D.

    2003-01-01

    Since 1958, the Commissariat a l'Energie Atomique and then the Institut de Radioprotection et de Surete Nucleaire (previously the Institut de Protection et de Surete Nucleaire) have carried out criticality experiments first in Saclay and then in the Valduc criticality laboratory. This paper is a survey of the programs conducted during the last 45 yr with the different apparatuses. This paper also gives information about plans for the future. Programs are presented following the chronology and the International Criticality Safety Benchmark Evaluation Project classification. Among the numerous series of experiments, now 22 series (corresponding to 407 configurations) have been included in the 'International Handbook of Evaluated Criticality Safety Benchmark Experiments'

  6. Electron versus proton accelerator driven sub-critical system performance using TRIGA reactors at power

    International Nuclear Information System (INIS)

    Carta, M.; Burgio, N.; D'Angelo, A.; Santagata, A.; Petrovich, C.; Schikorr, M.; Beller, D.; Felice, L. S.; Imel, G.; Salvatores, M.

    2006-01-01

    This paper provides a comparison of the performance of an electron accelerator-driven experiment, under discussion within the Reactor Accelerator Coupling Experiments (RACE) Project, being conducted within the U.S. Dept. of Energy's Advanced Fuel Cycle Initiative (AFCI), and of the proton-driven experiment TRADE (TRIGA Accelerator Driven Experiment) originally planned at ENEA-Casaccia in Italy. Both experiments foresee the coupling to sub-critical TRIGA core configurations, and are aimed to investigate the relevant kinetic and dynamic accelerator-driven systems (ADS) core behavior characteristics in the presence of thermal reactivity feedback effects. TRADE was based on the coupling of an upgraded proton cyclotron, producing neutrons via spallation reactions on a tantalum (Ta) target, with the core driven at a maximum power around 200 kW. RACE is based on the coupling of an Electron Linac accelerator, producing neutrons via photoneutron reactions on a tungsten-copper (W-Cu) or uranium (U) target, with the core driven at a maximum power around 50 kW. The paper is focused on analysis of expected dynamic power response of the RACE core following reactivity and/or source transients. TRADE and RACE target-core power coupling coefficients are compared and discussed. (authors)

  7. Critical components of odors in evaluating the performance of food waste composting plants

    International Nuclear Information System (INIS)

    Mao, I-F.; Tsai, C.-J.; Shen, S.-H.; Lin, T.-F.; Chen, W.-K.; Chen, M.-L.

    2006-01-01

    The current Taiwan government policy toward food waste management encourages composting for resource recovery. This study used olfactometry, gas chromatography-mass spectrometry (GC-MS) and gas detector tubes to evaluate the ambient air at three of the largest food waste composting plants in Taiwan. Ambient air inside the plants, at exhaust outlets and plant boundaries was examined to determine the comprehensive odor performance, critical components, and odor elimination efficiencies of various odor control engineering. Analytical results identified 29 compounds, including ammonia, amines, acetic acid, and multiple volatile organic compounds (VOCs) (hydrocarbons, ketones, esters, terpenes and S-compounds) in the odor from food waste composting plants. Concentrations of six components - ammonia, amines, dimethyl sulfide, acetic acid, ethyl benzene and p-Cymene - exceeded human olfactory thresholds. Ammonia, amines, dimethyl sulfide and acetic acid accounted for most odors compared to numerous VOCs. The results also show that the biotrickling filter was better at eliminating the concentrations of odor, NH 3 , amines, S-compounds and VOCs than the chemical scrubber and biofilters. All levels measured by olfactometry at the boundaries of food waste composting plants (range, 74-115 Odor Concentration (OC)) exceeded Taiwan's EPA standard of 50 OC. This study indicated that the malodor problem continued to be a significant problem for food waste recovery

  8. Critical components of odors in evaluating the performance of food waste composting plants

    Energy Technology Data Exchange (ETDEWEB)

    Mao, I-F. [Institute of Environmental Health Sciences, National Yang-Ming University, No. 155, Sec.2, Li-Nong St., Beitou, Taipei, Taiwan (China)]. E-mail: ifmao@ym.edu.tw; Tsai, C.-J. [Institute of Environmental Health Sciences, National Yang-Ming University, No. 155, Sec.2, Li-Nong St., Beitou, Taipei, Taiwan (China); Shen, S.-H. [Department of Environment Management, Jin Wen Institute of Technology, No. 99, An-Chung Rd., Hsin-Tien City, Taipei, Taiwan (China); Lin, T.-F. [Institute of Environmental Engineering, National Cheng Kung University, No. 1, Ta-Hsueh Rd., Tainan, Taiwan (China); Chen, W.-K. [Department of Environment Management, Jin Wen Institute of Technology, No. 99, An-Chung Rd., Hsin-Tien City, Taipei, Taiwan (China); Chen, M.-L. [Institute of Environmental Health Sciences, National Yang-Ming University, No. 155, Sec.2, Li-Nong St., Beitou, Taipei, Taiwan (China)]. E-mail: mlchen@ym.edu.tw

    2006-11-01

    The current Taiwan government policy toward food waste management encourages composting for resource recovery. This study used olfactometry, gas chromatography-mass spectrometry (GC-MS) and gas detector tubes to evaluate the ambient air at three of the largest food waste composting plants in Taiwan. Ambient air inside the plants, at exhaust outlets and plant boundaries was examined to determine the comprehensive odor performance, critical components, and odor elimination efficiencies of various odor control engineering. Analytical results identified 29 compounds, including ammonia, amines, acetic acid, and multiple volatile organic compounds (VOCs) (hydrocarbons, ketones, esters, terpenes and S-compounds) in the odor from food waste composting plants. Concentrations of six components - ammonia, amines, dimethyl sulfide, acetic acid, ethyl benzene and p-Cymene - exceeded human olfactory thresholds. Ammonia, amines, dimethyl sulfide and acetic acid accounted for most odors compared to numerous VOCs. The results also show that the biotrickling filter was better at eliminating the concentrations of odor, NH{sub 3}, amines, S-compounds and VOCs than the chemical scrubber and biofilters. All levels measured by olfactometry at the boundaries of food waste composting plants (range, 74-115 Odor Concentration (OC)) exceeded Taiwan's EPA standard of 50 OC. This study indicated that the malodor problem continued to be a significant problem for food waste recovery.

  9. Predicting fatigue and psychophysiological test performance from speech for safety critical environments

    Directory of Open Access Journals (Sweden)

    Khan Richard Baykaner

    2015-08-01

    Full Text Available Automatic systems for estimating operator fatigue have application in safety-critical environments. A system which could estimate level of fatigue from speech would have application in domains where operators engage in regular verbal communication as part of their duties. Previous studies on the prediction of fatigue from speech have been limited because of their reliance on subjective ratings and because they lack comparison to other methods for assessing fatigue. In this paper we present an analysis of voice recordings and psychophysiological test scores collected from seven aerospace personnel during a training task in which they remained awake for 60 hours. We show that voice features and test scores are affected by both the total time spent awake and the time position within each subject’s circadian cycle. However, we show that time spent awake and time of day information are poor predictors of the test results; while voice features can give good predictions of the psychophysiological test scores and sleep latency. Mean absolute errors of prediction are possible within about 17.5% for sleep latency and 5-12% for test scores. We discuss the implications for the use of voice as a means to monitor the effects of fatigue on cognitive performance in practical applications.

  10. Validity Evidence for a Serious Game to Assess Performance on Critical Pediatric Emergency Medicine Scenarios.

    Science.gov (United States)

    Gerard, James M; Scalzo, Anthony J; Borgman, Matthew A; Watson, Christopher M; Byrnes, Chelsie E; Chang, Todd P; Auerbach, Marc; Kessler, David O; Feldman, Brian L; Payne, Brian S; Nibras, Sohail; Chokshi, Riti K; Lopreiato, Joseph O

    2018-01-26

    We developed a first-person serious game, PediatricSim, to teach and assess performances on seven critical pediatric scenarios (anaphylaxis, bronchiolitis, diabetic ketoacidosis, respiratory failure, seizure, septic shock, and supraventricular tachycardia). In the game, players are placed in the role of a code leader and direct patient management by selecting from various assessment and treatment options. The objective of this study was to obtain supportive validity evidence for the PediatricSim game scores. Game content was developed by 11 subject matter experts and followed the American Heart Association's 2011 Pediatric Advanced Life Support Provider Manual and other authoritative references. Sixty subjects with three different levels of experience were enrolled to play the game. Before game play, subjects completed a 40-item written pretest of knowledge. Game scores were compared between subject groups using scoring rubrics developed for the scenarios. Validity evidence was established and interpreted according to Messick's framework. Content validity was supported by a game development process that involved expert experience, focused literature review, and pilot testing. Subjects rated the game favorably for engagement, realism, and educational value. Interrater agreement on game scoring was excellent (intraclass correlation coefficient = 0.91, 95% confidence interval = 0.89-0.9). Game scores were higher for attendings followed by residents then medical students (Pc game and written test scores (r = 0.84, P game scores to assess knowledge of pediatric emergency medicine resuscitation.

  11. Tsc1 is a Critical Regulator of Macrophage Survival and Function

    Directory of Open Access Journals (Sweden)

    Chunmin Fang

    2015-07-01

    Full Text Available Background/Aims: Tuberous sclerosis complex 1 (Tsc1 has been shown to regulate M1/M2 polarization of macrophages, but the precise roles of Tsc1 in the function and stability of macrophages are not fully understood. Here we show that Tsc1 is required for regulating the survival, migration and phagocytosis of macrophages. Methods: Mice with Tsc1 homozygous deletion in myeloid cells (LysMCreTsc1flox/flox; Tsc1 KO were obtained by crossing Tsc1flox/flox mice with mice expressing Cre recombinase under the control of Lysozyme promoter (LysMCre. The apoptosis and growth of macrophages were determined by flow cytometry and Real-time PCR (RT-PCR. The phagocytosis was determined using a Vybrant™ phagocytosis assay kit. The migration of macrophages was determined using transwell migration assay. Results: Peritoneal macrophages of Tsc1 KO mice exhibited increased apoptosis and enlarged cell size. Both M1 and M2 phenotypes in Tsc1-deficient macrophages were elevated in steady-state as well as in inflammatory conditions. Tsc1-deficient macrophages demonstrated impaired migration and reduced expression of chemokine receptors including CCR2 and CCR5. Phagocytosis activity and ROS production were enhanced in Tsc1-deficient macrophages. Furthermore, pharmacological inhibition of the mammalian target of rapamycin complex 1 (mTORC1 partially reversed the aberrance of Tsc1-deficient macrophages. Conclusion: Tsc1 plays a critical role in regulating macrophage survival, function and polarization via inhibition of mTORC1 activity.

  12. Predicting critical temperatures of iron(II) spin crossover materials: Density functional theory plus U approach

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yachao, E-mail: yczhang@nano.gznc.edu.cn [Guizhou Provincial Key Laboratory of Computational Nano-Material Science, Guizhou Normal College, Guiyang 550018, Guizhou (China)

    2014-12-07

    A first-principles study of critical temperatures (T{sub c}) of spin crossover (SCO) materials requires accurate description of the strongly correlated 3d electrons as well as much computational effort. This task is still a challenge for the widely used local density or generalized gradient approximations (LDA/GGA) and hybrid functionals. One remedy, termed density functional theory plus U (DFT+U) approach, introduces a Hubbard U term to deal with the localized electrons at marginal computational cost, while treats the delocalized electrons with LDA/GGA. Here, we employ the DFT+U approach to investigate the T{sub c} of a pair of iron(II) SCO molecular crystals (α and β phase), where identical constituent molecules are packed in different ways. We first calculate the adiabatic high spin-low spin energy splitting ΔE{sub HL} and molecular vibrational frequencies in both spin states, then obtain the temperature dependent enthalpy and entropy changes (ΔH and ΔS), and finally extract T{sub c} by exploiting the ΔH/T − T and ΔS − T relationships. The results are in agreement with experiment. Analysis of geometries and electronic structures shows that the local ligand field in the α phase is slightly weakened by the H-bondings involving the ligand atoms and the specific crystal packing style. We find that this effect is largely responsible for the difference in T{sub c} of the two phases. This study shows the applicability of the DFT+U approach for predicting T{sub c} of SCO materials, and provides a clear insight into the subtle influence of the crystal packing effects on SCO behavior.

  13. Propionyl-L-carnitine improves endothelial function, microcirculation and pain management in critical limb ischemia.

    Science.gov (United States)

    De Marchi, S; Zecchetto, S; Rigoni, A; Prior, M; Fondrieschi, L; Scuro, A; Rulfo, F; Arosio, E

    2012-10-01

    Chronic critical limb ischemia (CLI) is a severe condition of hypo-perfusion of lower limbs, which is associated with inflammation and a pro-coagulative state. It is a disease at high risk of amputation and cardiovascular death. Propionyl-L-carnitine (PLC) is efficacious in improving pain free walking distance in peripheral arterial disease with claudication; it also exerts favorable effects on the arterial wall and on endothelial function. The purpose of this study was to evaluate the effects of PLC on microcirculation, endothelial function and pain relief in patients affected by CLI not suitable for surgical intervention. We enrolled 48 patients with CLI. Patients were randomized into two groups: the first group was treated with PLC, the second was treated with saline solution. All of them underwent the following tests: laser Doppler flowmetry at the forefoot at rest and after ischemia, trans cutaneous oxygen partial pressure and carbon dioxide partial pressure at the forefoot at rest and after ischemia, endothelium dependent dilation of the brachial artery. All tests were repeated after treatments. Pain was assessed by visual analog pain scale. Endothelium dependent dilation increased after PLC (9.5 ± 3.2 vs 4.9 ± 1.4 %; p < 0.05). Post-ischemic peak flow with laser-Doppler flow increased after PLC. TcPO2 increased, while TcPCO2 decreased after PLC; CO2 production decreased after PLC. VAS showed a significant reduction in pain perception after active treatment. In CLI patients, PLC can improve microcirculation (post ischemic hyperemia, TcPO2 and TcPCO2 production). PLC also enhances endothelium dependent dilation and reduces analgesic consumption and pain perception.

  14. Stereotyped high-frequency oscillations discriminate seizure onset zones and critical functional cortex in focal epilepsy.

    Science.gov (United States)

    Liu, Su; Gurses, Candan; Sha, Zhiyi; Quach, Michael M; Sencer, Altay; Bebek, Nerses; Curry, Daniel J; Prabhu, Sujit; Tummala, Sudhakar; Henry, Thomas R; Ince, Nuri F

    2018-01-30

    High-frequency oscillations in local field potentials recorded with intracranial EEG are putative biomarkers of seizure onset zones in epileptic brain. However, localized 80-500 Hz oscillations can also be recorded from normal and non-epileptic cerebral structures. When defined only by rate or frequency, physiological high-frequency oscillations are indistinguishable from pathological ones, which limit their application in epilepsy presurgical planning. We hypothesized that pathological high-frequency oscillations occur in a repetitive fashion with a similar waveform morphology that specifically indicates seizure onset zones. We investigated the waveform patterns of automatically detected high-frequency oscillations in 13 epilepsy patients and five control subjects, with an average of 73 subdural and intracerebral electrodes recorded per patient. The repetitive oscillatory waveforms were identified by using a pipeline of unsupervised machine learning techniques and were then correlated with independently clinician-defined seizure onset zones. Consistently in all patients, the stereotypical high-frequency oscillations with the highest degree of waveform similarity were localized within the seizure onset zones only, whereas the channels generating high-frequency oscillations embedded in random waveforms were found in the functional regions independent from the epileptogenic locations. The repetitive waveform pattern was more evident in fast ripples compared to ripples, suggesting a potential association between waveform repetition and the underlying pathological network. Our findings provided a new tool for the interpretation of pathological high-frequency oscillations that can be efficiently applied to distinguish seizure onset zones from functionally important sites, which is a critical step towards the translation of these signature events into valid clinical biomarkers.awx374media15721572971001. © The Author(s) (2018). Published by Oxford University Press on

  15. Modeling the critical safety functions status tree of a NPP using FPGA

    International Nuclear Information System (INIS)

    Farias, Marcos Santana; Oliveira, Mauro Vitor de; Jaime, Guilherme Dutra Gonzaga; Almeida, Jose Carlos Soares de; Augusto, Silas Cordeiro

    2013-01-01

    Field Programmable Gate Arrays (FPGAs) based systems and equipment are beginning to appear in new plants I and C applications, as well as in retrofits for operating plants, in particular for safety applications due to their capability to face the systems obsolescence since they are circuit independent. The circuits implemented can be portable to different FPGAs architectures. Moreover, they reduce complexity for regulatory approval as compared to conventional microprocessor-based systems. Critical safety function (CSF) is the most significant design concept for prioritize operator actions for NPP based on the potential threat to the three barriers (fuel cladding, primary coolant system boundary, and containment) and allows the operator to respond to these threats prior to event diagnosis. CSF has a hierarchical information structure that organizes the system variables affecting the plant safety in terms of goal-means relations. This paper describes the application of FPGA in the implementation of the CSFs status tree logic for a Westinghouse 3-loops NPP simulator. (author)

  16. Executive Functioning: Relationship with High School Student Role Performance

    Directory of Open Access Journals (Sweden)

    Donna P. Mann

    2015-10-01

    Full Text Available BACKGROUND. Student role performance for academic success in secondary education is under represented in the occupational therapy literature, despite the persistently high dropout rate in the United States (Stillwell & Sable, 2013. Executive dysfunction is one of many possible contributors to difficulties in the classroom (Dirette & Kolak, 2004 and is a better indicator of school performance than IQ (Diamond, 2012. This research examined executive functioning of both alternative and traditional high school students to determine if there is a relationship between executive function and academic success as measured by cumulative grade point average. METHOD. 132 high school students from three different school settings were given the Behavioral Rating Inventory of Executive Function-Self Report (BRIEF-SR. The Global Executive Composite (GEC and individual subscale scores were compared to GPA. RESULTS. No significant difference in GEC scores was found among settings. Subscale scores for “inhibition” and “task completion” were significantly different in the alternative school setting. A weak negative correlation was seen between the GEC and GPA. However, academically unsuccessful students scored statistically lower on the GEC. CONCLUSION. Global executive dysfunction was not predicted by setting but was seen in academically unsuccessful students.

  17. Unraveling the Effects of Critical Thinking Instructions, Practice, and Self-Explanation on Students' Reasoning Performance

    Science.gov (United States)

    Heijltjes, Anita; van Gog, Tamara; Leppink, Jimmie; Paas, Fred

    2015-01-01

    Acquisition of critical thinking skills is considered an important goal in higher education, but it is still unclear which specific instructional techniques are effective for fostering it. The main aim of this study was to unravel the impact of critical thinking instructions, practice, and self-explanation prompts during practice, on students'…

  18. Unraveling the effects of critical thinking instructions, practice, and self-explanation on students’ reasoning performance

    NARCIS (Netherlands)

    Heijltjes, Anita; van Gog, Tamara; Leppink, Jimmie; Paas, Fred

    2015-01-01

    Acquisition of critical thinking skills is considered an important goal in higher education, but it is still unclear which specific instructional techniques are effective for fostering it. The main aim of this study was to unravel the impact of critical thinking instructions, practice, and

  19. Critical Thinking Skills among Elementary School Students: Comparing Identified Gifted and General Education Student Performance

    Science.gov (United States)

    Kettler, Todd

    2014-01-01

    Education reform efforts, including the current adoption of Common Core State Standards, have increased attention to teaching critical thinking skills to all students. This study investigated the critical thinking skills of fourth-grade students from a school district in Texas, including 45 identified gifted students and 163 general education…

  20. Critical Correlation Functions for the 4-Dimensional Weakly Self-Avoiding Walk and n-Component {|\\varphi|^4} Model

    Science.gov (United States)

    Slade, Gordon; Tomberg, Alexandre

    2016-03-01

    We extend and apply a rigorous renormalisation group method to study critical correlation functions, on the 4-dimensional lattice Z4, for the weakly coupled n-component {|\\varphi|4} spin model for all {n ≥ 1}, and for the continuous-time weakly self-avoiding walk. For the {|\\varphi|4} model, we prove that the critical two-point function has | x|-2 (Gaussian) decay asymptotically, for {n ≥ 1}. We also determine the asymptotic decay of the critical correlations of the squares of components of {\\varphi}, including the logarithmic corrections to Gaussian scaling, for {n ≥ 1}. The above extends previously known results for n = 1 to all {n ≥ 1}, and also observes new phenomena for n > 1, all with a new method of proof. For the continuous-time weakly self-avoiding walk, we determine the decay of the critical generating function for the "watermelon" network consisting of p weakly mutually- and self-avoiding walks, for all {p ≥ 1}, including the logarithmic corrections. This extends a previously known result for p = 1, for which there is no logarithmic correction, to a much more general setting. In addition, for both models, we study the approach to the critical point and prove the existence of logarithmic corrections to scaling for certain correlation functions. Our method gives a rigorous analysis of the weakly self-avoiding walk as the n = 0 case of the {|\\varphi|4} model, and provides a unified treatment of both models, and of all the above results.

  1. Effects of hippotherapy on gross motor function and functional performance of children with cerebral palsy.

    Science.gov (United States)

    Park, Eun Sook; Rha, Dong Wook; Shin, Jung Soon; Kim, Soohyeon; Jung, Soojin

    2014-11-01

    The purpose of our study was to investigate the effects of hippotherapy on gross motor function and functional performance in children with spastic cerebral palsy (CP). We recruited 34 children (M:F=15:19, age: 3-12 years) with spastic CP who underwent hippotherapy for 45 minutes twice a week for 8 weeks. Twenty-one children with spastic CP were recruited for control group. The distribution of gross motor function classification system level and mean age were not significantly different between the two groups. Outcome measures, including the Gross Motor Function Measure (GMFM)-66, GMFM-88 and the Pediatric Evaluation of Disability Inventory: Functional Skills Scale (PEDI-FSS), were assessed before therapy and after the 8-weeks intervention as outcome measures. There were no significant differences between intervention and control groups in mean baseline total scores of GMFM-66, GMFM-88 or PEDI-FSS. After the 8-weeks intervention, mean GMFM-66 and GMFM-88 scores were significantly improved in both groups. However, the hippotherapy group had significantly greater improvement in dimension E and GMFM-66 total score than the control group. The total PEDI-FSS score and the sub-scores of its 3 domains were significantly improved in the hippotherapy group, but not in the control group. The results of our study demonstrate the beneficial effects of hippotherapy on gross motor function and functional performance in children with CP compared to control group. The significant improvement in PEDI-FSS scores suggests that hippotherapy may be useful to maximize the functional performance of children with CP.

  2. An advanced probabilistic structural analysis method for implicit performance functions

    Science.gov (United States)

    Wu, Y.-T.; Millwater, H. R.; Cruse, T. A.

    1989-01-01

    In probabilistic structural analysis, the performance or response functions usually are implicitly defined and must be solved by numerical analysis methods such as finite element methods. In such cases, the most commonly used probabilistic analysis tool is the mean-based, second-moment method which provides only the first two statistical moments. This paper presents a generalized advanced mean value (AMV) method which is capable of establishing the distributions to provide additional information for reliability design. The method requires slightly more computations than the second-moment method but is highly efficient relative to the other alternative methods. In particular, the examples show that the AMV method can be used to solve problems involving non-monotonic functions that result in truncated distributions.

  3. Turboelectric Aircraft Drive Key Performance Parameters and Functional Requirements

    Science.gov (United States)

    Jansen, Ralph H.; Brown, Gerald V.; Felder, James L.; Duffy, Kirsten P.

    2016-01-01

    The purpose of this paper is to propose specific power and efficiency as the key performance parameters for a turboelectric aircraft power system and investigate their impact on the overall aircraft. Key functional requirements are identified that impact the power system design. Breguet range equations for a base aircraft and a turboelectric aircraft are found. The benefits and costs that may result from the turboelectric system are enumerated. A break-even analysis is conducted to find the minimum allowable electric drive specific power and efficiency that can preserve the range, initial weight, operating empty weight, and payload weight of the base aircraft.

  4. Conformal partition functions of critical percolation from D 3 thermodynamic Bethe Ansatz equations

    Science.gov (United States)

    Morin-Duchesne, Alexi; Klümper, Andreas; Pearce, Paul A.

    2017-08-01

    Using the planar Temperley-Lieb algebra, critical bond percolation on the square lattice can be reformulated as a loop model. In this form, it is incorporated as {{ L}}{{ M}}(2, 3) in the Yang-Baxter integrable family of logarithmic minimal models {{ L}}{{ M}}( p, p\\prime) . We consider this model of percolation in the presence of boundaries and with periodic boundary conditions. Inspired by Kuniba, Sakai and Suzuki, we rewrite the recently obtained infinite Y-system of functional equations. In this way, we obtain nonlinear integral equations in the form of a closed finite set of TBA equations described by a D 3 Dynkin diagram. Following the methods of Klümper and Pearce, we solve the TBA equations for the conformal finite-size corrections. For the ground states of the standard modules on the strip, these agree with the known central charge c  =  0 and conformal weights Δ1, s for \\renewcommand≥≥slant} s\\in {{ Z}≥slant 1} with Δr, s=\\big((3r-2s){\\hspace{0pt}}^2-1\\big)/24 . For the periodic case, the finite-size corrections agree with the conformal weights Δ0, s , Δ1, s with \\renewcommand{≥{≥slant} s\\in\\frac{1}{2}{{ Z}≥slant 0} . These are obtained analytically using Rogers dilogarithm identities. We incorporate all finite excitations by formulating empirical selection rules for the patterns of zeros of all the eigenvalues of the standard modules. We thus obtain the conformal partition functions on the cylinder and the modular invariant partition function (MIPF) on the torus. By applying q-binomial and q-Narayana identities, it is shown that our refined finitized characters on the strip agree with those of Pearce, Rasmussen and Zuber. For percolation on the torus, the MIPF is a non-diagonal sesquilinear form in affine u(1) characters given by the u(1) partition function Z2, 3(q)=Z2, 3{Circ}(q) . The u(1) operator content is {{ N}}Δ, \\barΔ=1 for Δ=\\barΔ=-\\frac{1}{24}, \\frac{35}{24} and {{ N}}Δ, \\barΔ=2 for

  5. Functionalized Materials From Elastomers to High Performance Thermoplastics

    Energy Technology Data Exchange (ETDEWEB)

    Salazar, Laura Ann [Iowa State Univ., Ames, IA (United States)

    2003-01-01

    Synthesis and incorporation of functionalized materials continues to generate significant research interest in academia and in industry. If chosen correctly, a functional group when incorporated into a polymer can deliver enhanced properties, such as adhesion, water solubility, thermal stability, etc. The utility of these new materials has been demonstrated in drug-delivery systems, coatings, membranes and compatibilizers. Two approaches exist to functionalize a material. The desired moiety can be added to the monomer either before or after polymerization. The polymers used range from low glass transition temperature elastomers to high glass transition temperature, high performance materials. One industrial example of the first approach is the synthesis of Teflon(reg. sign). Poly(tetrafluoroethylene) (PTFE or Teflon(reg. sign)) is synthesized from tetrafluoroethylene, a functionalized monomer. The resulting material has significant property differences from the parent, poly(ethylene). Due to the fluorine in the polymer, PTFE has excellent solvent and heat resistance, a low surface energy and a low coefficient of friction. This allows the material to be used in high temperature applications where the surface needs to be nonabrasive and nonstick. This material has a wide spread use in the cooking industry because it allows for ease of cooking and cleaning as a nonstick coating on cookware. One of the best examples of the second approach, functionalization after polymerization, is the vulcanization process used to make tires. Natural rubber (from the Hevea brasiliensis) has a very low glass transition temperature, is very tacky and would not be useful to make tires without synthetic alteration. Goodyear's invention was the vulcanization of polyisoprene by crosslinking the material with sulfur to create a rubber that was tough enough to withstand the elements of weather and road conditions. Due to the development of polymerization techniques to make cis

  6. Soil processes and functions in critical zone observatories: hypotheses and experimental design

    NARCIS (Netherlands)

    Banwart, S.; Bernasconi, S.M.; Bloem, J.; Blum, W.; Ruiter, de P.C.; Gaans, van P.; Riemsdijk, van W.H.

    2011-01-01

    European Union policy on soil threats and soil protection has prioritized new research to address global soil threats. This research draws on the methodology of Critical Zone Observatories (CZOs) to focus a critical mass of international, multidisciplinary expertise at specific field sites. These

  7. Salting a Wound or Sugaring a Pill: The Pragmatic Functions of Ironic Criticism.

    Science.gov (United States)

    Colston, Herbert L.

    1997-01-01

    Reports results of four experiments in which undergraduate students rated the degree of condemnation in critical remarks. Shows that ironic criticism in many cases is used to enhance rather than to dilute condemnation. Notes significant implications for both pragmatic and processing theories of verbal irony. (SR)

  8. The Effect of Criticism on Functional Brain Connectivity and Associations with Neuroticism

    NARCIS (Netherlands)

    Servaas, Michelle Nadine; Riese, Harriette; Renken, Remco Jan; Marsman, Jan-Bernard Cornelis; Lambregs, Johan; Ormel, Johan; Aleman, Andre

    2013-01-01

    Neuroticism is a robust personality trait that constitutes a risk factor for psychopathology, especially anxiety disorders and depression. High neurotic individuals tend to be more self-critical and are overly sensitive to criticism by others. Hence, we used a novel resting-state paradigm to

  9. Four hour creatinine clearance is better than plasma creatinine for monitoring renal function in critically ill patients

    Science.gov (United States)

    2012-01-01

    Introduction Acute kidney injury (AKI) diagnosis is based on an increase in plasma creatinine, which is a slowly changing surrogate of decreased glomerular filtration rate. We investigated whether serial creatinine clearance, a direct measure of the glomerular filtration rate, provided more timely and accurate information on renal function than serial plasma creatinine in critically ill patients. Methods Serial plasma creatinine and 4-hour creatinine clearance were measured 12-hourly for 24 hours and then daily in 484 patients. AKI was defined either as > 50% increase in plasma creatinine from baseline, or > 33.3% decrease in creatinine clearance. The diagnostic and predictive performance of the two AKI definitions were compared. Results Creatinine clearance decrease diagnosed AKI in 24% of those not diagnosed by plasma creatinine increase on entry. These patients entered the ICU sooner after insult than those diagnosed with AKI by plasma creatinine elevation (P = 0.0041). Mortality and dialysis requirement increased with the change in creatinine clearance-acute kidney injury severity class (P = 0.0021). Amongst patients with plasma creatinine creatinine clearance improved the prediction of AKI considerably (Net Reclassification Improvement 83%, Integrated Discrimination Improvement 0.29). On-entry, creatinine clearance associated with AKI severity and duration (P 33.3% decrease in creatinine clearance over the first 12 hours was associated with a 2.0-fold increased relative risk of dialysis or death. Conclusions Repeated 4-hour creatinine clearance measurements in critically ill patients allow earlier detection of AKI, as well as progression and recovery compared to plasma creatinine. Trial Registration Australian New Zealand Clinical Trials Registry ACTRN012606000032550. PMID:22713519

  10. Hydrological functioning of West-African inland valleys explored with a critical zone model

    Science.gov (United States)

    Hector, B.; Cohard, J. M.; Séguis, L.; Peugeot, C.; Galle, S.

    2017-12-01

    In west Africa, recurrent floods are still a major issue, and hydropower has been recognized as an important development pathway. Furthermore, inland valleys carry an important agronomic potential, which could meet the necessary increase of the crop production associated with the strong demographic rates of the region. This can lead to land cover and subsequent hydrologic changes. However, the hydrological role of the inland valleys in the humid, hard rock-dominated Sudanian area is not yet well understood, specifically for streamflow (Q) generation processes. We address both the questions of the hydrological functioning of inland valleys in the Sudanian area of West-Africa and the impact of land cover changes on these systems through deterministic sensitivity experiments using a physically-based critical zone model (ParFlow-CLM) applied on a synthetic catchment which comprises an inland valley. The conceptual lithological/pedological model for the catchment includes the main features of such a hydrological elementary unit derived from the literature and from a previously published model based on data from a highly instrumented elementary catchment. Model forcings and parameters are based on data from the AMMA-CATCH observation service and multiple field experiments. We found yearly water budgets were much more sensitive to vegetation distribution than lithology features of the inland valley (presence of the low permeability layer commonly found below the inland valley and the hydrodynamic properties of upstream and lateral areas). Yearly evapotranspiration budget between a fully tree-covered and an herbaceous-covered catchment increases between 6 and 21% of the precipitation of the year (depending on the tested cases) which reduces considerably the yearly streamflow budgets ( 30%). On the other hand, the lithology distribution has clear impacts on the spatial distribution of water storage dynamics.

  11. The role of nutritional support in the physical and functional recovery of critically ill patients: a narrative review.

    Science.gov (United States)

    Bear, Danielle E; Wandrag, Liesl; Merriweather, Judith L; Connolly, Bronwen; Hart, Nicholas; Grocott, Michael P W

    2017-08-26

    The lack of benefit from randomised controlled trials has resulted in significant controversy regarding the role of nutrition during critical illness in terms of long-term recovery and outcome. Although methodological caveats with a failure to adequately appreciate biological mechanisms may explain these disappointing results, it must be acknowledged that nutritional support during early critical illness, when considered alone, may have limited long-term functional impact.This narrative review focuses specifically on recent clinical trials and evaluates the impact of nutrition during critical illness on long-term physical and functional recovery.Specific focus on the trial design and methodological limitations has been considered in detail. Limitations include delivery of caloric and protein targets, patient heterogeneity, short duration of intervention, inappropriate clinical outcomes and a disregard for baseline nutritional status and nutritional intake in the post-ICU period.With survivorship at the forefront of critical care research, it is imperative that nutrition studies carefully consider biological mechanisms and trial design because these factors can strongly influence outcomes, in particular long-term physical and functional outcome. Failure to do so may lead to inconclusive clinical trials and consequent rejection of the potentially beneficial effects of nutrition interventions during critical illness.

  12. Translation and adaptation of functional auditory performance indicators (FAPI

    Directory of Open Access Journals (Sweden)

    Karina Ferreira

    2011-12-01

    Full Text Available Work with deaf children has gained new attention since the expectation and goal of therapy has expanded to language development and subsequent language learning. Many clinical tests were developed for evaluation of speech sound perception in young children in response to the need for accurate assessment of hearing skills that developed from the use of individual hearing aids or cochlear implants. These tests also allow the evaluation of the rehabilitation program. However, few of these tests are available in Portuguese. Evaluation with the Functional Auditory Performance Indicators (FAPI generates a child's functional auditory skills profile, which lists auditory skills in an integrated and hierarchical order. It has seven hierarchical categories, including sound awareness, meaningful sound, auditory feedback, sound source localizing, auditory discrimination, short-term auditory memory, and linguistic auditory processing. FAPI evaluation allows the therapist to map the child's hearing profile performance, determine the target for increasing the hearing abilities, and develop an effective therapeutic plan. Objective: Since the FAPI is an American test, the inventory was adapted for application in the Brazilian population. Material and Methods: The translation was done following the steps of translation and back translation, and reproducibility was evaluated. Four translated versions (two originals and two back-translated were compared, and revisions were done to ensure language adaptation and grammatical and idiomatic equivalence. Results: The inventory was duly translated and adapted. Conclusion: Further studies about the application of the translated FAPI are necessary to make the test practicable in Brazilian clinical use.

  13. Performance of supercritical Brayton cycle using CO2-based binary mixture at varying critical points for SFR applications

    International Nuclear Information System (INIS)

    Jeong, Woo Seok; Jeong, Yong Hoon

    2013-01-01

    Highlights: • Supercritical CO 2 -based gas mixture Brayton cycles were investigated for a SFR. • The critical point of CO 2 is the lowest cycle operating limit of the S-CO 2 cycles. • Mixing additives with CO 2 changes the CO 2 critical point. • CO 2 –Xe and CO 2 –Kr cycles achieve higher cycle efficiencies than the S-CO 2 cycles. • CO 2 –H 2 S and CO 2 –cyclohexane cycles perform better at higher heat sink temperatures. -- Abstract: The supercritical carbon dioxide Brayton cycle (S-CO 2 cycle) has attracted much attention as an alternative to the Rankine cycle for sodium-cooled fast reactors (SFRs). The higher cycle efficiency of the S-CO 2 cycle results from the considerably decreased compressor work because the compressor behaves as a pump in the proximity of the CO 2 vapor–liquid critical point. In order to fully utilize this feature, the main compressor inlet condition should be controlled to be close to the critical point of CO 2 . This indicates that the critical point of CO 2 is a constraint on the minimum cycle condition for S-CO 2 cycles. Modifying the CO 2 critical point by mixing additive gases could be considered as a method of enhancing the performance and broadening the applicability of the S-CO 2 cycle. Due to the drastic fluctuations of the thermo-physical properties of fluids near the critical point, an in-house cycle analysis code using the NIST REFPROP database was implemented. Several gases were selected as potential additives considering their thermal stability and chemical interaction with sodium in the temperature range of interest and the availability of the mixture property database: xenon, krypton, hydrogen sulfide, and cyclohexane. The performances of the optimized CO 2 -containing binary mixture cycles with simple recuperated and recompression layouts were compared with the reference S-CO 2 , CO 2 –Ar, CO 2 –N 2 , and CO 2 –O 2 cycles. For the decreased critical temperatures, the CO 2 –Xe and CO 2

  14. Functional Performance and Associations between Performance Tests and Neurological Assessment Differ in Men and Women with Parkinson’s Disease

    OpenAIRE

    Medijainen, Kadri; Pääsuke, Mati; Lukmann, Aet; Taba, Pille

    2015-01-01

    Background. Neurological assessment of a patient with Parkinson's disease (PD) is expected to reflect upon functional performance. As women are known to report more limitations even for same observed functional performance level, present study was designed to examine whether associations between neurological assessments and functional performance differ across genders. Methods. 14 men and 14 women with PD participated. Functional performance was assessed by measuring walking speeds on 10-mete...

  15. Optical functional performance of the osteo-odonto-keratoprosthesis.

    Science.gov (United States)

    Lee, Richard M H; Ong, Gek L; Lam, Fook Chang; White, Joy; Crook, David; Liu, Christopher S C; Hull, Chris C

    2014-10-01

    The aim of this study was to evaluate optical and visual functional performance of the osteo-odonto-keratoprosthesis (OOKP). Optical design and analysis was performed with customized optical design software. Nine patients with implanted OOKP devices and 9 age-matched control patients were assessed. Contrast sensitivity was assessed and glare effect was measured with a brightness acuity test. All OOKP patients underwent kinetic Goldmann perimetry and wavefront aberrometry and completed the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25). Optical analysis showed that the optical cylinder is near diffraction-limited. A reduction in median visual acuity (VA) with increasing glare settings was observed from 0.04 logMAR (without glare) to 0.20 logMAR (with glare at "high" setting) and significantly reduced statistically when compared with the control group at all levels of glare (P < 0.05). Contrast sensitivity was significantly reduced when compared with age-matched controls at medium and high spatial frequencies (P < 0.05). Median Goldmann perimetry was 65 degrees (interquartile range, 64-74 degrees; V-4e isopters) and 69 degrees excluding 2 glaucomatous subjects. Several vision-related NEI VFQ-25 subscales correlated significantly with VA at various brightness acuity test levels and contrast sensitivity at medium spatial frequencies, including dependency, general vision, near activities and distance activities. The OOKP optical cylinder provides patients with a good level of VA that is significantly reduced by glare. We have shown in vivo that updates to the optical cylinder design have improved the patient's field of view. Reduction of glare and refinement of cylinder alignment methods may further improve visual function and patient satisfaction.

  16. Identification and Ranking of Critical Success Factors of Knowledge Management Using Fuzzy Quality Function Deployment Approach: A Case Study

    Directory of Open Access Journals (Sweden)

    Ali Mohaghar

    2014-02-01

    Based on the information accessible for the researchers, this is one of the first works which evaluates the key factors of successful knowledge management through fuzzy quality function deployment approach. It is expected that the proposed method would represent appropriate tools for enterprises which have decided to implement knowledge management because it prioritizes the critical success factors based on the knowledge management outcomes.

  17. The Effect of Material Property on the Critical Velocity of Randomly Excited Nonlinear Axially Travelling Functionally Graded Plates

    Directory of Open Access Journals (Sweden)

    M. Abedi

    Full Text Available Abstract In this paper, the critical axial speeds of three types of sigmoid, power law and exponential law functionally graded plates for both isotropic and orthotropic cases are obtained via a completely analytic method. The plates are subjected to lateral white noise excitation and show evidence of large deformations. Due to randomness, the conventional deterministic methods fail and a statistical approach must be selected. Here, the probability density function is evaluated analytically for prescribed plates and used to investigate the critical axial velocity of them. Specifically the effect of in-plane forces, mean value of lateral load and the material property on the critical axial speed are studied and discussed for both isotropic and orthotropic functionally graded plates. Since the governing equation is transformed to a non dimensional format, the results can be used for a wide range of plate dimensions. It is shown that the material heterogeneity palys an essential and significant role in increasing or decreasing the critical speed of both isotropic and orthotropic functionally graded plates.

  18. The Criticality of Norms to the Functional Imperatives of the Social Action System of College and University Work

    Science.gov (United States)

    Braxton, John M.

    2010-01-01

    In this article, I assert that the work of colleges and universities forms a social action system. I array the critical positions represented in this issue according to the four functional imperatives of social action systems: adaptation, goal attainment, integration, and pattern maintenance. I discuss the role of normative structures for these…

  19. A cross selectional survey in a critical care: the job satisfaction and functioning team of the health professionals.

    Science.gov (United States)

    La Sala, Rachele; Boninsegni, Katiuscia; Tani, Alice; Rasi, Alice; Ricci, Barbara; Sansovini, Linda; Scarpelli, Giulia; Artioli, Giovanna; Sarli, Leopoldo

    2015-01-01

    Health care workers, especially those who are part of the OS core, are essential in the delivery of services, as they represent the institution at the time of the contact with the user and they represent also the image of the organization. Health administrations, therefore, are called to improve the performance through a better motivation and satisfaction of the staff, in view of two strategic aspects: job satisfaction of professionals and team collaboration. Between January and September 2014, a survey at the OU (UUOO) intensive care and sub intensive has been made inside three hospitals in Emilia Romagna. It' s been a multicentre cross-sectional quantitative study by administering a self-report questionnaire designed to investigate the different constructs. On 742 questionnaires were spread 454 professionals gave it back  (response rate = 73%). Of those, 273 (60.1%) were nurses, 119 (26.2%) were physicians and 62 (13.7%) were healthcare operators. 62 (13.7%) Job Satisfaction was measured with the McCloskey Mueller Satisfaction Scale. Team Functioning was measured with the Index of Interprofessional Team Collaboration. Results from MANOVA indicated that physicians were less satisfied of scheduling than both nurses and healthcare operators. For professional opportunities, instead, healthcare operators showed the lower level of satisfaction. The participants seem to perceive a high level of team effectiveness and therefore the professionals involved in the care of critically ill patients than the two dimensions analysed, (reflection between the processes and interdependent roles), also state a greater tendency to respect the roles interdisciplinary, maintaining their professional autonomy and a lower tendency to use critical thinking to act professionally in order to improve the effectiveness of care provided. The study results oriented healthcare administrators, to take paths that feed the job satisfaction and the collaboration of professionals by developing the

  20. Critical Shoulder Angle and Acromial Index Do Not Influence 24-Month Functional Outcome After Arthroscopic Rotator Cuff Repair.

    Science.gov (United States)

    Lee, Merrill; Chen, Jerry Yongqian; Liow, Ming Han Lincoln; Chong, Hwei Chi; Chang, Paul; Lie, Denny

    2017-11-01

    Recent studies have shown a correlation between scapular geometry and the development of atraumatic rotator cuff tears. However, a paucity of literature is available on the effects of critical shoulder angle (CSA) and acromial index (AI) on functional outcomes after arthroscopic rotator cuff repair. Hypothesis/Purpose: The purpose was to investigate the influence of CSA and AI on 24-month functional outcomes after arthroscopic rotator cuff repair. The hypothesis was that a larger CSA or AI would result in poorer postoperative outcomes. Cohort study; Level of evidence, 3. The study included 147 patients who underwent arthroscopic double-row rotator cuff repair for radiologically documented full-thickness supraspinatus tears. An independent reviewer measured the CSA and AI on preoperative radiographs. These patients were prospectively enrolled and were evaluated preoperatively as well as at 3, 6, 12, and 24 months postoperatively. Functional outcome was assessed with the Constant Shoulder Score (CSS), Oxford Shoulder Score (OSS), and University of California at Los Angeles (UCLA) Shoulder Rating Scale. The patients were first divided based on CSA: (1) ≤35° (control CSA) and (2) >35° (increased CSA); and then based on AI: (1) ≤0.7 and (2) >0.7. The Student unpaired t test, Pearson chi-square test, and Pearson correlation were performed to examine the influence of CSA and AI on postoperative functional outcome scores. At 6 months of follow-up, the CSS, OSS, and UCLA Shoulder Rating Scale were 10 ± 1, 4 ± 2, and 3 ± 1 points poorer in the increased CSA group compared with the control CSA group ( P = .005, P = .030, and P = .035, respectively). These scores were not significantly different between both AI groups. By 24 months of follow-up, all outcome scores were comparable between both CSA groups as well as between both AI groups. No significant correlation was found between either CSA or AI when compared with CSS, OSS, or UCLA Shoulder Rating Scale at 24

  1. Relationship Between the Functional Status Scale and the Pediatric Overall Performance Category and Pediatric Cerebral Performance Category Scales FREE

    Science.gov (United States)

    Pollack, Murray M.; Holubkov, Richard; Funai, Tomohiko; Clark, Amy; Moler, Frank; Shanley, Thomas; Meert, Kathy; Newth, Christopher J. L.; Carcillo, Joseph; Berger, John T.; Doctor, Allan; Berg, Robert A.; Dalton, Heidi; Wessel, David L.; Harrison, Rick E.; Dean, J. Michael; Jenkins, Tammara L.

    2015-01-01

    Importance Functional status assessment methods are important as outcome measures for pediatric critical care studies. Objective To investigate the relationships between the 2 functional status assessment methods appropriate for large-sample studies, the Functional Status Scale (FSS) and the Pediatric Overall Performance Category and Pediatric Cerebral Performance Category (POPC/PCPC) scales. Design, Setting, and Participants Prospective cohort study with random patient selection at 7 sites and 8 children’s hospitals with general/medical and cardiac/cardiovascular pediatric intensive care units (PICUs) in the Collaborative Pediatric Critical Care Research Network. Participants included all PICU patients younger than 18 years. Main Outcomes and Measures Functional Status Scale and POPC/PCPC scores determined at PICU admission (baseline) and PICU discharge. We investigated the association between the baseline and PICU discharge POPC/PCPC scores and the baseline and PICU discharge FSS scores, the dispersion of FSS scores within each of the POPC/PCPC ratings, and the relationship between the FSS neurologic components (FSS-CNS) and the PCPC. Results We included 5017 patients. We found a significant (P < .001) difference between FSS scores in each POPC or PCPC interval, with an FSS score increase with each worsening POPC/PCPC rating. The FSS scores for the good and mild disability POPC/PCPC ratings were similar and increased by 2 to 3 points for the POPC/PCPC change from mild to moderate disability, 5 to 6 points for moderate to severe disability, and 8 to 9 points for severe disability to vegetative state or coma. The dispersion of FSS scores within each POPC and PCPC rating was substantial and increased with worsening POPC and PCPC scores. We also found a significant (P < .001) difference between the FSS-CNS scores between each of the PCPC ratings with increases in the FSS-CNS score for each higher PCPC rating. Conclusions and Relevance The FSS and POPC/PCPC system

  2. Performance Evaluation and Analysis of Critical Interface Features of the National Compact Stellarator Experiment (NCSX)

    International Nuclear Information System (INIS)

    Freudenberg, Kevin D.; Litherland, P. Steve; Cole, Michael J.; Williamson, David E.; Goranson, Paul L.; Nelson, Brad E.; Heitzenroeder, P.; Myatt, R.

    2009-01-01

    The (18) modular coils for the National Compact Stellarator Experiment (NCSX) are joined at assembly by interfaces to form a toroidal shell which serves as the structural backbone of the device. There are six each of three coil types (A, B, and C); consequently, there are 4 distinct interface designs (A-A, A-B, B-C, C-C). This paper describes the performance evaluations and analyses used in the development of these critical interfaces. Initial analyses indicated that the baseline interface designs did not provide adequate shear capability along the inner (unbolted) legs between the modular coils and did not adequately address assembly tolerance requirements. Consequently a design effort was undertaken to develop interfaces with adequate shear capability and which would facilitate the achievement of assembly tolerances. Analyses indicated that a friction coefficient of 0.3 is necessary for 'no-slip' joints with a preload value of ∼320 kN in the outboard regions. Two types of compatible segmented friction shims were developed to meet the friction requirement. One type uses alumina coated stainless steel shims and the other uses G-10/ stainless steel/ G-10 'sandwich shims.' Analyses indicated that the time constant requirements for induced currents in the shell could still be achieved with welds along all the inner (unbolted) legs except at the C-C interface. Consequently, welded interfaces utilizing alternating MIG fillet welds on each end of shims between coil castings were developed to react the shear loads. This configuration minimizes distortion since it avoids direct weld shrinkage stress across the interfaces. Analyses indicates that a 12.7 mm fillet weld has adequate shear capability, with average stress through the welds of 90-125 MPa, compared to a static limit of 217 MPa. Custom sized compression pucks located in the middle of the welded shims react the compressive loads and have average stresses less than 137 MPa. Fatigue acceptability of the welded

  3. Islamic Banking in Global Economic Context (Critical Studies of Operational System and Performance of Islamic Banking

    Directory of Open Access Journals (Sweden)

    Jamal Abdul Aziz

    2018-01-01

    Full Text Available Berdasarkan kajian terhadap sejarah kemunculan dan sistem operasional Bank Islam beserta kinerjanya, penulis menyimpulkan bahwa konsep bank Islam pada hakekatnya merupakan bentuk islamisasi terhadap institusi perbankan. Hanya saja proses islamisasi yang terjadi baru sebatas pada aspek-aspek yang bersifat marginal, artifisial, dan formal-institusional, seperti penggantian istilah-istilah teknis dalam dunia perbankan dengan istilah yang berasal dari fikih muamalah, penghapusan bunga, dan penolakan terhadap praktek-praktek bisnis yang haram. Selebihnya, bank Islam tidak berbeda dengan bank konvensional. Dampak dari islamisasi yang kurang substansial-komprehensif tersebut adalah timbulnya kesan bahwa bank Islam justru ‘terbelenggu’ oleh konsep-konsep fikih klasik yang mendasarinya, di mana ia cenderung kontra produktif dengan tren  bisnis moderen yang senantiasa menuntut efisiensi dan fleksibilitas. Agar tetap dapat survive di masa-masa mendatang, bank Islam perlu mengevaluasi diri secara terus menerus dengan selalu membuka diri terhadap berbagai kritikan yang dialamatkan kepadanya. Konsepsi yang terlalu berorientasi kepada doktrin harus diimbangi dengan kesadaran akan fakta-fakta dan tuntutan bisnis moderen, baik yang berskala lokal maupun global. Sementara itu cita-cita Islam yang ideal, seperti pemberantasan kemiskinan, pendistribusian kekayaan secara adil, dan penciptaan lapangan kerja, harus tetap menjadi orientasi utamanya. Kata Kunci:Riba, Profit and Loss Sharing, Mudlârabah, Murâbahah, Artificial Aspects of Islam  Abstract:Based on the study of the history of emergence and operation of Islamic Bank and its system performance, the author conclude that the concept of Islamic bank is essentially a form of Islamization of the banking institutions. Such Islamization are limited to the marginal, artificial, and formal-institutional aspects, such as the replacement of technical terms in the banking world with a term derived from the fiqh

  4. Assessing the performance of maternity care in Europe: a critical exploration of tools and indicators.

    Science.gov (United States)

    Escuriet, Ramón; White, Joanna; Beeckman, Katrien; Frith, Lucy; Leon-Larios, Fatima; Loytved, Christine; Luyben, Ans; Sinclair, Marlene; van Teijlingen, Edwin

    2015-11-02

    This paper critically reviews published tools and indicators currently used to measure maternity care performance within Europe, focusing particularly on whether and how current approaches enable systematic appraisal of processes of minimal (or non-) intervention in support of physiological or "normal birth". The work formed part of COST Actions IS0907: "Childbirth Cultures, Concerns, and Consequences: Creating a dynamic EU framework for optimal maternity care" (2011-2014) and IS1405: Building Intrapartum Research Through Health - an interdisciplinary whole system approach to understanding and contextualising physiological labour and birth (BIRTH) (2014-). The Actions included the sharing of country experiences with the aim of promoting salutogenic approaches to maternity care. A structured literature search was conducted of material published between 2005 and 2013, incorporating research databases, published documents in english in peer-reviewed international journals and indicator databases which measured aspects of health care at a national and pan-national level. Given its emergence from two COST Actions the work, inevitably, focused on Europe, but findings may be relevant to other countries and regions. A total of 388 indicators were identified, as well as seven tools specifically designed for capturing aspects of maternity care. Intrapartum care was the most frequently measured feature, through the application of process and outcome indicators. Postnatal and neonatal care of mother and baby were the least appraised areas. An over-riding focus on the quantification of technical intervention and adverse or undesirable outcomes was identified. Vaginal birth (no instruments) was occasionally cited as an indicator; besides this measurement few of the 388 indicators were found to be assessing non-intervention or "good" or positive outcomes more generally. The tools and indicators identified largely enable measurement of technical interventions and undesirable

  5. Storying Teacher Education Policy: Critical Counternarratives of Curricular, Pedagogical, and Activist Responses to State-Mandated Teacher Performance Assessments

    Science.gov (United States)

    Henning, Nick; Dover, Alison; Dotson, Erica K.; Agarwal-Rangath, Ruchi

    2018-01-01

    The rise of high-stakes, standardized, teacher performance assessments (TPAs) is central to the industry being created out of the regulation, policing, and evaluation of university-based teacher education In addition to reinforcing a narrow and counter-critical framework, TPAs can shift responsibility for the evaluation of teacher candidates from…

  6. Critical success factors influencing the performance of development projects: An empirical study of Constituency Development Fund projects in Kenya

    OpenAIRE

    Debadyuti Das; Christopher Ngacho

    2017-01-01

    The present work attempts to identify critical success factors (CSFs) influencing the performance of development projects based on their key performance indicators (KPIs). It has considered the case of Constituency Development Fund (CDF) projects constructed between 2003 and 2011 in Kenya and secured the perceptions of 175 respondents comprising clients, consultants and contractors involved in the implementation of CDF projects on 30 success variables. Findings reveal that individual items co...

  7. Performance of the New Turbine Mid-Level Critical Care Ventilators.

    Science.gov (United States)

    Delgado, Carlos; Romero, Jose E; Puig, Jaume; Izquierdo, Ana; Ferrando, Carlos; Belda, F Javier; Soro, Marina

    2017-01-01

    During recent years, ventilators using turbines as flow-generating systems have become increasingly more relevant. This bench study was designed to compare triggering and pressurization of 7 turbine mid-level ICU ventilators. We used a dual-chamber lung model to test 7 mid-level ICU ventilators in pressure support mode with levels of 10, 15, and 20 cm H 2 O with 2 PEEP levels of 5 cm H 2 O and the minimum level allowed by the ventilator. A ventilator was connected to the master chamber to simulate 2 different effort levels. Pressure drop, trigger delay time, time to minimum pressure, and pressure time products (PTP) during trigger and the first 300 and 500 ms were analyzed. In the trigger evaluation, the Savina had the highest delay time, whereas the C2, the V60, and the Trilogy had the lowest pressure drops and PTP values in both effort levels. In pressurization capacity assessment using ideal PTP300 and PTP500 percentages, the C2 and the V680 had the best results, and the Carina and the Savina had lower values, with no differences between both effort levels. Differences between PEEP levels did not seem to be relevant. Pressure support mode for tested ventilators worked properly, but pressurization capacity and trigger function performance were clearly superior in the newest machines. The use of PEEP did not modify the results. Copyright © 2017 by Daedalus Enterprises.

  8. Safeguarding the functions and performance of instrumentation and control systems

    International Nuclear Information System (INIS)

    Koehler, M.; Schoerner, O.

    1996-01-01

    Based on an analysis of the existing nuclear power plant control technology, the necessity of providing in the medium-term advanced and future-oriented, digital control system, both for normal operation and for safety-relevant tasks of the reactor and safety control systems. Siemens KWU has been promoting the development, review and marketing of the digital instrumentation and control systems called TELEPERM XS and TELEPERM XP in addition to the measures taken for safeguarding the functions of existing, wired systems. The paper briefly explains the performance and advantages of digital systems and the progress in approval and pioneering of the TELEPERM XS safety control system. Many examples discussed show the diversity of applications of the systems both in new reactor plants and as retrofitting measures, for KWU power plants and those of other manufacturers. (orig.) [de

  9. A short review of critical experiments performed at the Kurchatov Institute

    Energy Technology Data Exchange (ETDEWEB)

    Gagarinski, A.Yu.; Glushkov, Y.S.; Ponomarev-Stepnoi, N.N. [Kurchatov Institute (Russian Federation)

    1997-06-01

    Since the 1950s, the Institute of Atomic Energy (now the Russian Research Center Kurchatov Institute) has investigated nuclear reactors intended for various purposes. A summary of the present state of these assemblies is given in an attachment to the paper. A second attachment provides a brief description of critical experiments for small nuclear power systems intended for decentralized power generation. The critical assemblies for these experiments were moderated by water and zirconium hydride, and fuel elements ranged in enrichment from 5% to 95% uranium 235. 7 refs.

  10. A short review of critical experiments performed at the Kurchatov Institute

    International Nuclear Information System (INIS)

    Gagarinski, A.Yu.; Glushkov, Y.S.; Ponomarev-Stepnoi, N.N.

    1997-01-01

    Since the 1950s, the Institute of Atomic Energy (now the Russian Research Center Kurchatov Institute) has investigated nuclear reactors intended for various purposes. A summary of the present state of these assemblies is given in an attachment to the paper. A second attachment provides a brief description of critical experiments for small nuclear power systems intended for decentralized power generation. The critical assemblies for these experiments were moderated by water and zirconium hydride, and fuel elements ranged in enrichment from 5% to 95% uranium 235. 7 refs

  11. Redefining "Critical" Bone Loss in Shoulder Instability: Functional Outcomes Worsen With "Subcritical" Bone Loss.

    Science.gov (United States)

    Shaha, James S; Cook, Jay B; Song, Daniel J; Rowles, Douglas J; Bottoni, Craig R; Shaha, Steven H; Tokish, John M

    2015-07-01

    Glenoid bone loss is a common finding in association with anterior shoulder instability. This loss has been identified as a predictor of failure after operative stabilization procedures. Historically, 20% to 25% has been accepted as the "critical" cutoff where glenoid bone loss should be addressed in a primary procedure. Few data are available, however, on lesser, "subcritical" amounts of bone loss (below the 20%-25% range) on functional outcomes and failure rates after primary arthroscopic stabilization for shoulder instability. To evaluate the effect of glenoid bone loss, especially in subcritical bone loss (below the 20%-25% range), on outcomes assessments and redislocation rates after an isolated arthroscopic Bankart repair for anterior shoulder instability. Cohort study; Level of evidence, 3. Subjects were 72 consecutive anterior instability patients (73 shoulders) who underwent isolated anterior arthroscopic labral repair at a single military institution by 1 of 3 sports medicine fellowship-trained orthopaedic surgeons. Data were collected on demographics, the Western Ontario Shoulder Instability (WOSI) score, Single Assessment Numeric Evaluation (SANE) score, and failure rates. Failure was defined as recurrent dislocation. Glenoid bone loss was calculated via a standardized technique on preoperative imaging. The average bone loss across the group was calculated, and patients were divided into quartiles based on the percentage of glenoid bone loss. Outcomes were analyzed for the entire cohort, between the quartiles, and within each quartile. Outcomes were then further stratified between those sustaining a recurrence versus those who remained stable. The mean age at surgery was 26.3 years (range, 20-42 years), and the mean follow-up was 48.3 months (range, 23-58 months). The cohort was divided into quartiles based on bone loss. Quartile 1 (n = 18) had a mean bone loss of 2.8% (range, 0%-7.1%), quartile 2 (n = 19) had 10.4% (range, 7.3%-13.5%), quartile 3 (n

  12. Analysis of core-periphery organization in protein contact networks reveals groups of structurally and functionally critical residues.

    Science.gov (United States)

    Isaac, Arnold Emerson; Sinha, Sitabhra

    2015-10-01

    The representation of proteins as networks of interacting amino acids, referred to as protein contact networks (PCN), and their subsequent analyses using graph theoretic tools, can provide novel insights into the key functional roles of specific groups of residues. We have characterized the networks corresponding to the native states of 66 proteins (belonging to different families) in terms of their core-periphery organization. The resulting hierarchical classification of the amino acid constituents of a protein arranges the residues into successive layers - having higher core order - with increasing connection density, ranging from a sparsely linked periphery to a densely intra-connected core (distinct from the earlier concept of protein core defined in terms of the three-dimensional geometry of the native state, which has least solvent accessibility). Our results show that residues in the inner cores are more conserved than those at the periphery. Underlining the functional importance of the network core, we see that the receptor sites for known ligand molecules of most proteins occur in the innermost core. Furthermore, the association of residues with structural pockets and cavities in binding or active sites increases with the core order. From mutation sensitivity analysis, we show that the probability of deleterious or intolerant mutations also increases with the core order. We also show that stabilization centre residues are in the innermost cores, suggesting that the network core is critically important in maintaining the structural stability of the protein. A publicly available Web resource for performing core-periphery analysis of any protein whose native state is known has been made available by us at http://www.imsc.res.in/ ~sitabhra/proteinKcore/index.html.

  13. Heat Transfer Performance of Functionalized Graphene Nanoplatelet Aqueous Nanofluids

    Directory of Open Access Journals (Sweden)

    Roberto Agromayor

    2016-06-01

    Full Text Available The low thermal conductivity of fluids used in many industrial applications is one of the primary limitations in the development of more efficient heat transfer systems. A promising solution to this problem is the suspension of nanoparticles with high thermal conductivities in a base fluid. These suspensions, known as nanofluids, have great potential for enhancing heat transfer. The heat transfer enhancement of sulfonic acid-functionalized graphene nanoplatelet water-based nanofluids is addressed in this work. A new experimental setup was designed for this purpose. Convection coefficients, pressure drops, and thermophysical properties of various nanofluids at different concentrations were measured for several operational conditions and the results are compared with those of pure water. Enhancements in thermal conductivity and in convection heat transfer coefficient reach 12% (1 wt % and 32% (0.5 wt %, respectively. New correlations capable of predicting the Nusselt number and the friction factor of this kind of nanofluid as a function of other dimensionless quantities are developed. In addition, thermal performance factors are obtained from the experimental convection coefficient and pressure drop data in order to assess the convenience of replacing the base fluid with designed nanofluids.

  14. The Watson-Glaser Critical Thinking Appraisal and the Performance of Business Management Students.

    Science.gov (United States)

    Hicks, R. E.; Southey, G. N.

    1990-01-01

    The 80-item Watson-Glaser Critical Thinking Appraisal-Form A was administered to 415 business management students in Australia as a step toward adapting the test for Australian use. The results correspond reasonably closely to the U.S. data. Analysis of group results and item statistics provided information about necessary modifications. (SLD)

  15. Ocean container transport : an underestimated and critical link in global supply chain performance

    NARCIS (Netherlands)

    Fransoo, J.C.; Lee, C.Y.

    2010-01-01

    With supply chains distributed across global markets, ocean container transport now is a critical element of any such supply chain. We identify key characteristics of ocean container transport from a supply chain perspective. We find that unlike continental (road) transport, service offerings tend

  16. Thinking Critically, Speaking Famously, and Writing Effortlessly: An Alternative Performative Public Speaking Assignment

    Science.gov (United States)

    Charlesworth, Dacia

    2005-01-01

    Although the concepts of style and delivery occupy a significant portion of any public speaking class, students often fail to make use of stylistic devices or delivery techniques while writing and presenting their speeches. This activity invites students to critically analyze a public speech and then present the critique using their own voice…

  17. The critical role of ocean container transport in global supply chain performance

    NARCIS (Netherlands)

    Fransoo, J.C.; Lee, C.Y.

    2013-01-01

    With supply chains distributed across global markets, ocean container transport now is a critical element of any such supply chain. We identify key characteristics of ocean container transport from a supply chain perspective. We find that unlike continental (road) transport, service offerings tend

  18. Impaired Job Performance and Critical Incidents: Factors Influencing Supervisory EAP Referrals.

    Science.gov (United States)

    Harley, David A.

    Relatively little empirical research has been done on the supervisory referral of employees to employee assistance programs (EAPs). Inclusion of constructive confrontation (supervisory referral) into program standards and its continued promotion as a "central strategy" of program theory and operation calls for critical investigation of…

  19. How Activists and Media Frame Social Problems: Critical Events versus Performance Trends for Schools.

    Science.gov (United States)

    Pride, Richard A.

    1995-01-01

    Focuses on the process by which a social problem is redefined in response to a critical events, such as economic depressions, environmental disasters, intense physical confrontations, or strategic initiatives by a social movement organization. Examines a conservative movement's attempt to redefine "the problem" of the schools at the time…

  20. LEGAL PRINCIPLES IN FUNCTION AND PERFORMANCE OF BOT CONTRACT

    Directory of Open Access Journals (Sweden)

    Reifon Cristabella Eventia

    2017-09-01

    Full Text Available Build, Operate and Transfer (BOT represents a long term partnership of the government and private sector. In BOT project, either the government or a private sector identifies a need for a development project. The philosophy in BOT contract begins from the increasing infrastructural needs in all areas and with a limited budget, government are required to commit the duties and functions state governance so that the concept of BOT give a solution through a partnership with the private sector. The government then gives a concession to the private sector to build the project and operate it for a fixed period years, after the period ended, the building shall be transferred to the government. Through BOT, the country is able to gain asset without government spending while maintaining a measure of regulatory control over the project. BOT permits the government to use private sector fund to finance public infrastructure development. The main issues elaborated in this article are the legal principle in the formation of BOT contract and the legal principle in the performance of BOT contract. There are two results; firstly, in the formation of a BOT contract, the principles of partnership and the principle of transparency should be emphasized. Secondly, in performance of the BOT contract, the principle of risk management and the principle of proportionality should be clearly stated in the rules and legal norms.

  1. Approaching human performance the functionality-driven Awiwi robot hand

    CERN Document Server

    Grebenstein, Markus

    2014-01-01

    Humanoid robotics have made remarkable progress since the dawn of robotics. So why don't we have humanoid robot assistants in day-to-day life yet? This book analyzes the keys to building a successful humanoid robot for field robotics, where collisions become an unavoidable part of the game. The author argues that the design goal should be real anthropomorphism, as opposed to mere human-like appearance. He deduces three major characteristics to aim for when designing a humanoid robot, particularly robot hands: _ Robustness against impacts _ Fast dynamics _ Human-like grasping and manipulation performance   Instead of blindly copying human anatomy, this book opts for a holistic design me-tho-do-lo-gy. It analyzes human hands and existing robot hands to elucidate the important functionalities that are the building blocks toward these necessary characteristics.They are the keys to designing an anthropomorphic robot hand, as illustrated in the high performance anthropomorphic Awiwi Hand presented in this book.  ...

  2. Effects of Menstrual Phase on Pulmonary Function and Exercise Performance in Young Active Duty Women

    National Research Council Canada - National Science Library

    Hnatiuk, Oleh

    1996-01-01

    ....' However, if the APFT is given to female soldiers during a phase of their menstrual cycle when their ability to perform maximally is reduced, this critical test would not be an accurate reflection of true maximal performance level.

  3. Mitochondrial Function in an In Vitro Model of Skeletal Muscle of Patients With Protracted Critical Illness and Intensive Care Unit-Acquired Weakness.

    Science.gov (United States)

    Jiroutková, Kateřina; Krajčová, Adéla; Žiak, Jakub; Fric, Michal; Gojda, Jan; Džupa, Valér; Kalous, Martin; Tůmová, Jana; Trnka, Jan; Duška, František

    2017-09-01

    Functional mitochondria in skeletal muscle of patients with protracted critical illness and intensive care unit-acquired weakness are depleted, but remaining mitochondria have increased functional capacities of respiratory complexes II and III. This can be an adaptation to relative abundancy of fatty acid over glucose caused by insulin resistance. We hypothesized that the capacity of muscle mitochondria to oxidize fatty acid is increased in protracted critical illness. We assessed fatty acid oxidation (FAO) and mitochondrial functional indices in vitro by using extracellular flux analysis in cultured myotubes obtained by isolating and culturing satellite cells from vastus lateralis muscle biopsy samples from patients with ICU-acquired weakness (n = 6) and age-matched healthy controls (n = 7). Bioenergetic measurements were performed at baseline and after 6 days of exposure to free fatty acids (FFAs). Mitochondrial density in myotubes from ICU patients was 69% of healthy controls ( P = .051). After adjustment to mitochondrial content, there were no differences in adenosine triphosphate (ATP) synthesis or the capacity and coupling of the respiratory chain. FAO capacity in ICU patients was 157% of FAO capacity in controls ( P = .015). In myotubes of ICU patients, unlike healthy controls, the exposure to FFA significantly ( P = .009) increased maximum respiratory chain capacity. In an in vitro model of skeletal muscle of patients with protracted critical illness, we have shown signs of adaptation to increased FAO. Even in the presence of glucose and insulin, elevation of FFAs in the extracellular environment increased maximal capacity of the respiratory chain.

  4. Critical determinants of combined sprint and endurance performance: an integrative analysis from muscle fiber to the human body.

    Science.gov (United States)

    van der Zwaard, Stephan; van der Laarse, Willem J; Weide, Guido; Bloemers, Frank W; Hofmijster, Mathijs J; Levels, Koen; Noordhof, Dionne A; de Koning, Jos J; de Ruiter, Cornelis J; Jaspers, Richard T

    2018-04-01

    Optimizing physical performance is a major goal in current physiology. However, basic understanding of combining high sprint and endurance performance is currently lacking. This study identifies critical determinants of combined sprint and endurance performance using multiple regression analyses of physiologic determinants at different biologic levels. Cyclists, including 6 international sprint, 8 team pursuit, and 14 road cyclists, completed a Wingate test and 15-km time trial to obtain sprint and endurance performance results, respectively. Performance was normalized to lean body mass 2/3 to eliminate the influence of body size. Performance determinants were obtained from whole-body oxygen consumption, blood sampling, knee-extensor maximal force, muscle oxygenation, whole-muscle morphology, and muscle fiber histochemistry of musculus vastus lateralis. Normalized sprint performance was explained by percentage of fast-type fibers and muscle volume ( R 2 = 0.65; P body.

  5. Accuracy of subcutaneous continuous glucose monitoring in critically ill adults: improved sensor performance with enhanced calibrations.

    Science.gov (United States)

    Leelarathna, Lalantha; English, Shane W; Thabit, Hood; Caldwell, Karen; Allen, Janet M; Kumareswaran, Kavita; Wilinska, Malgorzata E; Nodale, Marianna; Haidar, Ahmad; Evans, Mark L; Burnstein, Rowan; Hovorka, Roman

    2014-02-01

    Accurate real-time continuous glucose measurements may improve glucose control in the critical care unit. We evaluated the accuracy of the FreeStyle(®) Navigator(®) (Abbott Diabetes Care, Alameda, CA) subcutaneous continuous glucose monitoring (CGM) device in critically ill adults using two methods of calibration. In a randomized trial, paired CGM and reference glucose (hourly arterial blood glucose [ABG]) were collected over a 48-h period from 24 adults with critical illness (mean±SD age, 60±14 years; mean±SD body mass index, 29.6±9.3 kg/m(2); mean±SD Acute Physiology and Chronic Health Evaluation score, 12±4 [range, 6-19]) and hyperglycemia. In 12 subjects, the CGM device was calibrated at variable intervals of 1-6 h using ABG. In the other 12 subjects, the sensor was calibrated according to the manufacturer's instructions (1, 2, 10, and 24 h) using arterial blood and the built-in point-of-care glucometer. In total, 1,060 CGM-ABG pairs were analyzed over the glucose range from 4.3 to 18.8 mmol/L. Using enhanced calibration median (interquartile range) every 169 (122-213) min, the absolute relative deviation was lower (7.0% [3.5, 13.0] vs. 12.8% [6.3, 21.8], P<0.001), and the percentage of points in the Clarke error grid Zone A was higher (87.8% vs. 70.2%). Accuracy of the Navigator CGM device during critical illness was comparable to that observed in non-critical care settings. Further significant improvements in accuracy may be obtained by frequent calibrations with ABG measurements.

  6. Experiments of Pool Boiling Performance (Boiling Heat Transfer and Critical Heat Flux) on Designed Micro-Structures

    International Nuclear Information System (INIS)

    Kim, Seol Ha; Kang, Jun Young; Lee, Gi Chol; Kiyofumia, Moriyama; Kim, Moo Hwan; Park, Hyun Sun

    2015-01-01

    In general, the evaluation of the boiling performance mainly focuses on two physical parameters: boiling heat transfer (BHT) and critical heat flux (CHF). In the nuclear power plants, both BHT and CHF contribute the nuclear system efficiency and safety, respectively. In this study, BHT and CHF of the pool boiling on well-organized fabricated structured (micro scaled) surface has been evaluated. As a results, BHT change on microstructured surface shows strongly dependent on Pin-fin effect analysis. In terms of CHF, critical size of micro structure for CHF enhancement has been observed and analyzed based on the capillary wicking effect. In this study, BHT and CHF of the pool boiling on well-organized fabricated structured (micro scaled) surface has been evaluated. As a results, BHT change on microstructured surface shows strongly dependent on the roughness ratio. The extended heat transfer area contributes the boiling heat transfer increase on the structured surface, and its quantitative analysis has been performed. In terms of CHF, the critical size of micro structure for CHF enhancement has been observed and analyzed based on the capillary wicking effect. We suggested a capillary limit to CHF delay for modeling capillary induced liquid inflow through microstructured surfaces. The critical size of the capillary limit on the prepared structured surface, determined by a model, could be reasonable explanation points for the experimental results (optimal size for CHF delay). The present experimental results also showed clearly the critical size (10 - 20 μm) for CHF delay, predicted by capillary limit analysis. This study provides fundamental insight into BHT and CHF enhancement of structured surfaces, and an optimal design guide for the required CHF and boiling heat-transfer performance. Finally, this study can contribute the basic understanding of the boiling on designed microstructure surface, and it also suggest the optimal micro scaled structured surface of boiling

  7. Gait improvement after treadmill training in ischemic stroke survivors: A critical review of functional MRI studies ☆

    OpenAIRE

    Xiao, Xiang; Huang, Dongfeng; O’Young, Bryan

    2012-01-01

    Stroke survivors often present with abnormal gait, movement training can improve the walking performance post-stroke, and functional MRI can objectively evaluate the brain functions before and after movement training. This paper analyzes the functional MRI changes in patients with ischemic stroke after treadmill training with voluntary and passive ankle dorsiflexion. Functional MRI showed that there are some changes in some regions of patients with ischemic stroke including primary sensorimot...

  8. A new functional site W115 in CdtA is critical for Aggregatibacter actinomycetemcomitans cytolethal distending toxin.

    Directory of Open Access Journals (Sweden)

    Lu Li

    Full Text Available Aggregatibacter actinomycetemcomitans, a specific pathogen of localized aggressive periodontitis, produces a cytolethal distending toxin (CDT that arrests eukaryotic cells irreversibly in G0/G1 or G2/M phase of the cell cycle. Although structural studies show that the aromatic patch region of CdtA plays an important role in its biological activity, the functional sites of CdtA have not been firmly established. In this study, site-specific mutagenesis strategy was employed for cdtA point mutations construction so as to examine the contributions of individual amino acids to receptor binding and the biological activity of holotoxin. The binding ability was reduced in CdtA(Y181ABC holotoxin and the biological function of CDT was not weaken in CdtA(Y105ABC, CdtA(Y125ABC, CdtA(F109ABC and CdtA(S106NBC holotoxin suggesting that these sites were not critical to CDT. But the binding activity and cell cycle arrest ability of holotoxin complexes were inhibited in CdtA(W115GBC. And this site did not affect the holotoxin assembly by size exclusion chromatography. Therefore, W115 might be a critical site of CdtA binding ability. These findings suggest that the functional sites of CdtA are not only in the aromatic patch region. W115, the new functional site is critical for receptor binding and cell cycle arrest, which provides potential targets for pharmacological disruption of CDT activity.

  9. A three critical point theorem for non-smooth functionals with ...

    Indian Academy of Sciences (India)

    1Department of Mathematics, Faculty of Mathematics Sciences, ... In many applications, we encounter problems with non-smooth energy functionals. These .... The next lemma shows that a locally Lipschitz functional with a compact gradient, is.

  10. Investigating the Correlation Between Pharmacy Student Performance on the Health Science Reasoning Test and a Critical Thinking Assignment.

    Science.gov (United States)

    Nornoo, Adwoa O; Jackson, Jonathan; Axtell, Samantha

    2017-03-25

    Objective. To determine whether there is a correlation between pharmacy students' scores on the Health Science Reasoning Test (HSRT) and their grade on a package insert assignment designed to assess critical thinking. Methods. The HSRT was administered to first-year pharmacy students during a critical-thinking course in the spring semester. In the same semester, a required package insert assignment was completed in a pharmacokinetics course. To determine whether there was a relationship between HSRT scores and grades on the assignment, a Spearman's rho correlation test was performed. Results. A very weak but significant positive correlation was found between students' grades on the assignment and their overall HSRT score (r=0.19, p critical-thinking skills in pharmacy students.

  11. Numerical simulation and experimental validation of internal heat exchanger influence on CO{sub 2} trans-critical cycle performance

    Energy Technology Data Exchange (ETDEWEB)

    Rigola, Joaquim; Ablanque, Nicolas; Perez-Segarra, Carlos D.; Oliva, Assensi [Centre Tecnologic de Transferencia de Calor (CTTC), Universitat Politecnica de Catalunya (UPC), ETSEIAT, C. Colom 11, 08222 Terrassa (Barcelona) (Spain)

    2010-06-15

    The present paper is a numerical and experimental comparative study of the whole vapour compression refrigerating cycle in general, and reciprocating compressors in particular, with the aim of showing the possibilities that CO{sub 2} offers for commercial refrigeration, considering a single-stage trans-critical cycle using semi-hermetic reciprocating compressors under small cooling capacity systems. The present work is focussed on the influence of using an internal heat exchanger (IHX) in order to improve the cycle performance under real working conditions. In order to validate the numerical results, an experimental unit specially designed and built to analyze trans-critical refrigerating equipments considering IHX has been built. Both numerical results and experimental data show reasonable good agreement, while the comparative global values conclude the improvement of cooling capacity and COP when IHX is considered in the CO{sub 2} trans-critical cycle. (author)

  12. Corpus linguistics, systemic functional grammar and literary meaning: a critical analysis of harry potter and the philosopher’s stone Corpus linguistics, systemic functional grammar and literary meaning: a critical analysis of harry potter and the philosopher’s stone

    Directory of Open Access Journals (Sweden)

    Andrew Goatly

    2008-04-01

    Full Text Available The research reported in this paper has two aims. First, to show how corpus linguistics, using word frequency and concordance data, which is then analysed according to transitivity systems of systemic functional grammar (SFG, can be useful to the enterprise of critical linguistics. Second, to investigate to what extent this critical corpus linguistics (CCL gives a valid representation of the meanings and ideologies of a literary text. The hypothesis tested is that semiotic models of communication, in this case of popular children’s literature, with their emphasis on the encoding and decoding of meanings, lend themselves to a corpus linguistics approach. But that, in fact, these mutually reinforcing approaches (SFG and CCL with their reliance on what is encoded as text cannot entirely succeed in accounting for how literature, in particular, is understood and interpreted, and how ideology works within it and behind it. For a richer critical discourse analysis we need a pragmatic account, for example an analysis of presupposition, inference and propositional attitude. The issues here will be discussed in the light of recent debate between Michael Stubbs and Henry Widdowson on the strengths and limitations of corpus linguistics in critical discourse analysis. The research reported in this paper has two aims. First, to show how corpus linguistics, using word frequency and concordance data, which is then analysed according to transitivity systems of systemic functional grammar (SFG, can be useful to the enterprise of critical linguistics. Second, to investigate to what extent this critical corpus linguistics (CCL gives a valid representation of the meanings and ideologies of a literary text. The hypothesis tested is that semiotic models of communication, in this case of popular children’s literature, with their emphasis on the encoding and decoding of meanings, lend themselves to a corpus linguistics approach. But that, in fact, these

  13. Developing safety performance functions incorporating reliability-based risk measures.

    Science.gov (United States)

    Ibrahim, Shewkar El-Bassiouni; Sayed, Tarek

    2011-11-01

    Current geometric design guides provide deterministic standards where the safety margin of the design output is generally unknown and there is little knowledge of the safety implications of deviating from these standards. Several studies have advocated probabilistic geometric design where reliability analysis can be used to account for the uncertainty in the design parameters and to provide a risk measure of the implication of deviation from design standards. However, there is currently no link between measures of design reliability and the quantification of safety using collision frequency. The analysis presented in this paper attempts to bridge this gap by incorporating a reliability-based quantitative risk measure such as the probability of non-compliance (P(nc)) in safety performance functions (SPFs). Establishing this link will allow admitting reliability-based design into traditional benefit-cost analysis and should lead to a wider application of the reliability technique in road design. The present application is concerned with the design of horizontal curves, where the limit state function is defined in terms of the available (supply) and stopping (demand) sight distances. A comprehensive collision and geometric design database of two-lane rural highways is used to investigate the effect of the probability of non-compliance on safety. The reliability analysis was carried out using the First Order Reliability Method (FORM). Two Negative Binomial (NB) SPFs were developed to compare models with and without the reliability-based risk measures. It was found that models incorporating the P(nc) provided a better fit to the data set than the traditional (without risk) NB SPFs for total, injury and fatality (I+F) and property damage only (PDO) collisions. Copyright © 2011 Elsevier Ltd. All rights reserved.

  14. Using Gordon's functional health patterns to organize a critical care orientation program.

    Science.gov (United States)

    Recker, D; O'Brien, C

    1992-02-01

    We have described how we revised our critical care orientation according to Gordon's FHPs. The process will require continuous review and revision. Research is necessary to determine the effectiveness of an orientation organized by a nursing framework in facilitating holistic nursing practice.

  15. For Function or Transformation? A Critical Discourse Analysis of Education under the Sustainable Development Goals

    Science.gov (United States)

    Brissett, Nigel; Mitter, Radhika

    2017-01-01

    We conduct a critical discourse analysis of the extent to which Sustainable Development Goal 4, "to ensure inclusive and equitable quality education for all and promote lifelong learning," promotes a utilitarian and/or transformative approach to education. Our findings show that despite transformative language used throughout the Agenda,…

  16. Critical structural and functional roles for the N-terminal insertion sequence in surfactant protein B analogs.

    Directory of Open Access Journals (Sweden)

    Frans J Walther

    2010-01-01

    Full Text Available Surfactant protein B (SP-B; 79 residues belongs to the saposin protein superfamily, and plays functional roles in lung surfactant. The disulfide cross-linked, N- and C-terminal domains of SP-B have been theoretically predicted to fold as charged, amphipathic helices, suggesting their participation in surfactant activities. Earlier structural studies with Mini-B, a disulfide-linked construct based on the N- and C-terminal regions of SP-B (i.e., approximately residues 8-25 and 63-78, confirmed that these neighboring domains are helical; moreover, Mini-B retains critical in vitro and in vivo surfactant functions of the native protein. Here, we perform similar analyses on a Super Mini-B construct that has native SP-B residues (1-7 attached to the N-terminus of Mini-B, to test whether the N-terminal sequence is also involved in surfactant activity.FTIR spectra of Mini-B and Super Mini-B in either lipids or lipid-mimics indicated that these peptides share similar conformations, with primary alpha-helix and secondary beta-sheet and loop-turns. Gel electrophoresis demonstrated that Super Mini-B was dimeric in SDS detergent-polyacrylamide, while Mini-B was monomeric. Surface plasmon resonance (SPR, predictive aggregation algorithms, and molecular dynamics (MD and docking simulations further suggested a preliminary model for dimeric Super Mini-B, in which monomers self-associate to form a dimer peptide with a "saposin-like" fold. Similar to native SP-B, both Mini-B and Super Mini-B exhibit in vitro activity with spread films showing near-zero minimum surface tension during cycling using captive bubble surfactometry. In vivo, Super Mini-B demonstrates oxygenation and dynamic compliance that are greater than Mini-B and compare favorably to full-length SP-B.Super Mini-B shows enhanced surfactant activity, probably due to the self-assembly of monomer peptide into dimer Super Mini-B that mimics the functions and putative structure of native SP-B.

  17. Potential Functional Embedding Theory at the Correlated Wave Function Level. 2. Error Sources and Performance Tests.

    Science.gov (United States)

    Cheng, Jin; Yu, Kuang; Libisch, Florian; Dieterich, Johannes M; Carter, Emily A

    2017-03-14

    Quantum mechanical embedding theories partition a complex system into multiple spatial regions that can use different electronic structure methods within each, to optimize trade-offs between accuracy and cost. The present work incorporates accurate but expensive correlated wave function (CW) methods for a subsystem containing the phenomenon or feature of greatest interest, while self-consistently capturing quantum effects of the surroundings using fast but less accurate density functional theory (DFT) approximations. We recently proposed two embedding methods [for a review, see: Acc. Chem. Res. 2014 , 47 , 2768 ]: density functional embedding theory (DFET) and potential functional embedding theory (PFET). DFET provides a fast but non-self-consistent density-based embedding scheme, whereas PFET offers a more rigorous theoretical framework to perform fully self-consistent, variational CW/DFT calculations [as defined in part 1, CW/DFT means subsystem 1(2) is treated with CW(DFT) methods]. When originally presented, PFET was only tested at the DFT/DFT level of theory as a proof of principle within a planewave (PW) basis. Part 1 of this two-part series demonstrated that PFET can be made to work well with mixed Gaussian type orbital (GTO)/PW bases, as long as optimized GTO bases and consistent electron-ion potentials are employed throughout. Here in part 2 we conduct the first PFET calculations at the CW/DFT level and compare them to DFET and full CW benchmarks. We test the performance of PFET at the CW/DFT level for a variety of types of interactions (hydrogen bonding, metallic, and ionic). By introducing an intermediate CW/DFT embedding scheme denoted DFET/PFET, we show how PFET remedies different types of errors in DFET, serving as a more robust type of embedding theory.

  18. Four hour creatinine clearance is better than plasma creatinine for monitoring renal function in critically ill patients

    OpenAIRE

    Pickering, John W; Frampton, Christopher M; Walker, Robert J; Shaw, Geoffrey M; Endre, Zolt?n H

    2012-01-01

    Introduction Acute kidney injury (AKI) diagnosis is based on an increase in plasma creatinine, which is a slowly changing surrogate of decreased glomerular filtration rate. We investigated whether serial creatinine clearance, a direct measure of the glomerular filtration rate, provided more timely and accurate information on renal function than serial plasma creatinine in critically ill patients. Methods Serial plasma creatinine and 4-hour creatinine clearance were measured 12-hourly for 24 h...

  19. Functional Performance and Associations between Performance Tests and Neurological Assessment Differ in Men and Women with Parkinson's Disease.

    Science.gov (United States)

    Medijainen, Kadri; Pääsuke, Mati; Lukmann, Aet; Taba, Pille

    2015-01-01

    Neurological assessment of a patient with Parkinson's disease (PD) is expected to reflect upon functional performance. As women are known to report more limitations even for same observed functional performance level, present study was designed to examine whether associations between neurological assessments and functional performance differ across genders. 14 men and 14 women with PD participated. Functional performance was assessed by measuring walking speeds on 10-meter walk test (10MWT) and by performing timed-up-and-go-test (TUG). Neurological assessment included Hoehn and Yahr Scale (HY), Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS), Schwab and England Activities of Daily Living Scale (S-E), and Mini Mental State Examination (MMSE). In women with PD, Kendall's tau-b correlation analyses revealed significant correlations between functional performance tests and neurological assessment measures, with the exception in MMSE. No corresponding associations were found for men, although they demonstrated better functional performance, as expected. Men in similar clinical stage of the PD perform better on functional tests than women. Disease severity reflects upon functional performance differently in men and women with PD. Results indicate that when interpreting the assessment results of both functional performance and neurological assessment tests, the gender of the patient should be taken into consideration.

  20. Functional Performance and Associations between Performance Tests and Neurological Assessment Differ in Men and Women with Parkinson’s Disease

    Directory of Open Access Journals (Sweden)

    Kadri Medijainen

    2015-01-01

    Full Text Available Background. Neurological assessment of a patient with Parkinson’s disease (PD is expected to reflect upon functional performance. As women are known to report more limitations even for same observed functional performance level, present study was designed to examine whether associations between neurological assessments and functional performance differ across genders. Methods. 14 men and 14 women with PD participated. Functional performance was assessed by measuring walking speeds on 10-meter walk test (10MWT and by performing timed-up-and-go-test (TUG. Neurological assessment included Hoehn and Yahr Scale (HY, Movement Disorders Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS, Schwab and England Activities of Daily Living Scale (S-E, and Mini Mental State Examination (MMSE. Results. In women with PD, Kendall’s tau-b correlation analyses revealed significant correlations between functional performance tests and neurological assessment measures, with the exception in MMSE. No corresponding associations were found for men, although they demonstrated better functional performance, as expected. Conclusion. Men in similar clinical stage of the PD perform better on functional tests than women. Disease severity reflects upon functional performance differently in men and women with PD. Results indicate that when interpreting the assessment results of both functional performance and neurological assessment tests, the gender of the patient should be taken into consideration.

  1. Penentuan Critical Parts Alat Bantu Pemeras Santan Menggunakan Quality Function Deployment Fase Kedua

    Directory of Open Access Journals (Sweden)

    Yuswono Hadi

    2017-08-01

    Full Text Available Some previous studies used QFD first phase method to obtain customer satisfaction of coconut milk squeezer machines, as follows: accelerates extortion process, reduces fatigue, easy to use, optimizes the output, strong construction, rustproof materials, compact design, easy to move, and hygienic. Study developing of the squeezer machine of coconut milk is required to deploy customer satisfaction into two parts including specifications and critical parts by using QFD second phase. There are 15 part specifications that obtained by discussing and interviewing with the experts. Then, 4 part specifications such as motor, pressing mechanism, production step, pressing strength, and volume of the cylinder were selected as main part to be used for QFD second phase. While there were 10 critical parts was derived from selected part specification such as pressure strength, hydraulic system, ON/OFF push button, cylinder clamps, the power and voltage that used for the machine,  the piston holder material, and its diameter.

  2. Wages or Other Conditions: A Critical Assessment of Factors in Workers Performance in Nigeria

    OpenAIRE

    A. M. Ogaboh Agba; W. A. Mboto; M. S. Agba

    2013-01-01

    The challenge of getting maximum performance from employees remain a perennial problem to managers in Nigeria. This challenge is aggravated by the great divide that exist among managers on which of the motivational factors stimulate workers the more into higher performance; while some tilt to monetary incentives; many more argue that non-monetary incentives are major motivating factors. Thus, this study is set to investigate factors that influence workers’ job performance in Nigeria. The stud...

  3. Individual reactions to stress predict performance during a critical aviation incident.

    Science.gov (United States)

    Vine, Samuel J; Uiga, Liis; Lavric, Aureliu; Moore, Lee J; Tsaneva-Atanasova, Krasimira; Wilson, Mark R

    2015-01-01

    Understanding the influence of stress on human performance is of theoretical and practical importance. An individual's reaction to stress predicts their subsequent performance; with a "challenge" response to stress leading to better performance than a "threat" response. However, this contention has not been tested in truly stressful environments with highly skilled individuals. Furthermore, the effect of challenge and threat responses on attentional control during visuomotor tasks is poorly understood. Thus, this study aimed to examine individual reactions to stress and their influence on attentional control, among a cohort of commercial pilots performing a stressful flight assessment. Sixteen pilots performed an "engine failure on take-off" scenario, in a high-fidelity flight simulator. Reactions to stress were indexed via self-report; performance was assessed subjectively (flight instructor assessment) and objectively (simulator metrics); gaze behavior data were captured using a mobile eye tracker, and measures of attentional control were subsequently calculated (search rate, stimulus driven attention, and entropy). Hierarchical regression analyses revealed that a threat response was associated with poorer performance and disrupted attentional control. The findings add to previous research showing that individual reactions to stress influence performance and shed light on the processes through which stress influences performance.

  4. Influence of moist combustion gas on performance of a sub-critical turbine

    International Nuclear Information System (INIS)

    Yang Wenbin; Su Ming

    2005-01-01

    In the HAT cycle, as the absolute humidity of the moist combustion gas increases, the performance of the turbine will also change. In this paper, one model to calculate the thermodynamic properties of the moist combustion gas is introduced, and another model to calculate the performance of the turbine is formulated based on the equations of one dimensional flow. Using these models with the geometric parameters of the turbine fixed, at the design working condition, the performance of the turbine is calculated and analyzed for different absolute humidities. Finally, some conclusions about the turbine performance are presented

  5. Understanding the Effects of Long-duration Space Flight on Astronant Functional Task Performance

    Science.gov (United States)

    Bloomberg, Jacob J.; Batson, Crystal D.; Buxton, Roxanne E.; Feiveson, Al H.; Kofman, Igor S.; Lee, Stuart M. C.; Miller, Chris A.; Mulavara, Ajitkumar P.; Peters, Brian T.; Phillips, Tiffany; hide

    2014-01-01

    Space flight is known to cause alterations in multiple physiological systems including changes in sensorimotor, cardiovascular, and neuromuscular systems. These physiological changes cause balance, gait and visual disturbances, cardiovascular deconditioning, and loss of muscle mass and strength. These changes may affect a crewmember's ability to perform critical mission tasks immediately after landing on a planetary surface. To understand how changes in physiological function affect functional performance, an interdisciplinary pre- and postflight testing regimen, Functional Task Test (FTT), was developed to systematically evaluate both astronaut functional performance and related physiological changes. Ultimately this information will be used to assess performance risks and inform the design of countermeasures for exploration class missions. We are currently conducting the FTT study on International Space Station (ISS) crewmembers before and after 6-month expeditions. Additionally, in a corresponding study we are using the FTT protocol on subjects before and after 70 days of 6deg head-down bed-rest as an analog for space flight. Bed-rest provides the opportunity for us to investigate the role of prolonged axial body unloading in isolation from the other physiological effects produced by exposure to the microgravity environment of space flight. Therefore, the bed rest analog allows us to investigate the impact of body unloading on both functional tasks and on the underlying physiological factors that lead to decrement in performance and then compare them with the results obtained in our space flight study. Functional tests included ladder climbing, hatch opening, jump down, manual manipulation of objects and tool use, seat egress and obstacle avoidance, recovery from a fall and object translation tasks. Physiological measures included assessments of postural and gait control, dynamic visual acuity, fine motor control, plasma volume, heart rate, blood pressure

  6. Non-critical string theory formulation of microtubule dynamics and quantum aspects of brain function

    CERN Document Server

    Mavromatos, Nikolaos E

    1995-01-01

    Microtubule (MT) networks, subneural paracrystalline cytosceletal structures, seem to play a fundamental role in the neurons. We cast here the complicated MT dynamics in the form of a 1+1-dimensional non-critical string theory, thus enabling us to provide a consistent quantum treatment of MTs, including enviromental {\\em friction} effects. We suggest, thus, that the MTs are the microsites, in the brain, for the emergence of stable, macroscopic quantum coherent states, identifiable with the {\\em preconscious states}. Quantum space-time effects, as described by non-critical string theory, trigger then an {\\em organized collapse} of the coherent states down to a specific or {\\em conscious state}. The whole process we estimate to take {\\cal O}(1\\,{\\rm sec}), in excellent agreement with a plethora of experimental/observational findings. The {\\em microscopic arrow of time}, endemic in non-critical string theory, and apparent here in the self-collapse process, provides a satisfactory and simple resolution to the age...

  7. Critical properties and high-pressure volumetric behavior of the carbon dioxide+propane system at T=308.15 k. Krichevskii function and related thermodynamic properties.

    Science.gov (United States)

    Blanco, Sofía T; Gil, Laura; García-Giménez, Pilar; Artal, Manuela; Otín, Santos; Velasco, Inmaculada

    2009-05-21

    Critical properties and volumetric behavior for the {CO2(1)+C3H8(2)} system have been studied. The critical locus was measured with a flow apparatus and detected by critical opalescence. For the mixtures, repeatabilities in critical temperature and pressure are rTcStructural properties such as direct and total correlation function integrals and cluster size were calculated using the Krichevskii function concept. Both the critical and volumetric behavior have been compared with literature data and with those obtained from the PC-SAFT and Patel-Teja equations of state.

  8. Effects of blueberries on inflammation, motor performance and cognitive function

    Science.gov (United States)

    Motor and cognitive function decrease with age, to include deficits in balance, coordination, gait, processing speed, executive function, memory, and spatial learning. These functional declines may be caused by long term increases in and susceptibility to oxidative stress and inflammation. Research ...

  9. Performance of density functional theory methods to describe ...

    Indian Academy of Sciences (India)

    Fukui function shows a small dependence with both the exchange and correlation functional and the basis set. Evolution of the Fukui function along the reaction path describes important changes in the basic sites of the corresponding molecules. These results are in agreement with the chemical behavior of those species.

  10. Neurokinin B is critical for normal timing of sexual maturation but dispensable for adult reproductive function in female mice.

    Science.gov (United States)

    True, Cadence; Nasrin Alam, Sayeda; Cox, Kimberly; Chan, Yee-Ming; Seminara, Stephanie B

    2015-04-01

    Humans carrying mutations in neurokinin B (NKB) or the NKB receptor fail to undergo puberty due to decreased secretion of GnRH. Despite this pubertal delay, many of these patients go on to achieve activation of their hypothalamic-pituitary-gonadal axis in adulthood, a phenomenon termed reversal, indicating that NKB signaling may play a more critical role for the timing of pubertal development than adult reproductive function. NKB receptor-deficient mice are hypogonadotropic but have no defects in the timing of sexual maturation. The current study has performed the first phenotypic evaluation of mice bearing mutations in Tac2, the gene encoding the NKB ligand, to determine whether they have impaired sexual development similar to their human counterparts. Male Tac2-/- mice showed no difference in the timing of sexual maturation or fertility compared with wild-type littermates and were fertile. In contrast, Tac2-/- females had profound delays in sexual maturation, with time to vaginal opening and first estrus occurring significantly later than controls, and initial abnormalities in estrous cycles. However, cycling recovered in adulthood and Tac2-/- females were fertile, although they produced fewer pups per litter. Thus, female Tac2-/- mice parallel humans harboring NKB pathway mutations, with delayed sexual maturation and activation of the reproductive cascade later in life. Moreover, direct comparison of NKB ligand and receptor-deficient females confirmed that only NKB ligand-deficient animals have delayed sexual maturation, suggesting that in the absence of the NKB receptor, NKB may regulate the timing of sexual maturation through other tachykinin receptors.

  11. Critical brand innovation factors (CBIF): understanding innovation and market performance in the Chinese high-tech service industry

    OpenAIRE

    Nguyen, Bang; Yu, Xiaoyu; Melewar, T. C.; Gupta, Suraksha

    2016-01-01

    Brand innovation sweeps aside established practices and disrupts the status quo, resulting in the transformation of markets. The present study develops and tests a model of critical brand innovation factors (CBIF) by examining key factors influencing firm-level brands' innovation and increased market performance. Adapting both organizational elements and market response characteristics, the model integrates four key variables in China's industrial service markets: innovation, internationaliza...

  12. Does Mindfulness Enhance Critical Thinking? Evidence for the Mediating Effects of Executive Functioning in the Relationship between Mindfulness and Critical Thinking

    OpenAIRE

    Noone, Chris; Bunting, Brendan; Hogan, Michael J.

    2016-01-01

    Mindfulness originated in the Buddhist tradition as a way of cultivating clarity of thought. Despite the fact that this behaviour is best captured using critical thinking assessments, no studies have examined the effects of mindfulness on critical thinking or the mechanisms underlying any such possible relationship. Even so, mindfulness has been suggested as being beneficial for critical thinking in higher education. Critical thinking is recognised as an important higher-order cognitive proce...

  13. Identifying the Critical Factors Affecting Safety Program Performance for Construction Projects within Pakistan Construction Industry

    Directory of Open Access Journals (Sweden)

    Zubair Ahmed Memon

    2013-04-01

    Full Text Available Many studies have shown that the construction industry one of the most hazardous industries with its high rates of fatalities and injuries and high financial losses incurred through work related accident. To reduce or overcome the safety issues on construction sites, different safety programs are introduced by construction firms. A questionnaire survey study was conducted to highlight the influence of the Construction Safety Factors on safety program implementation. The input from the questionnaire survey was analyzed by using AIM (Average Index Method and rank correlation test was conducted between different groups of respondents to measure the association between different groups of respondent. The finding of this study highlighted that management support is the critical factor for implementing the safety program on projects. From statistical test, it is concluded that all respondent groups were strongly in the favor of management support factor as CSF (Critical Success Factor. The findings of this study were validated on selected case studies. Results of the case studies will help to know the effect of the factors on implementing safety programs during the execution stage.

  14. eLearning to facilitate the education and implementation of the Chelsea Critical Care Physical Assessment: a novel measure of function in critical illness.

    Science.gov (United States)

    Corner, Evelyn J; Handy, Jonathan M; Brett, Stephen J

    2016-04-11

    To evaluate the efficacy of eLearning in the widespread standardised teaching, distribution and implementation of the Chelsea Critical Care Physical Assessment (CPAx) tool-a validated tool to assess physical function in critically ill patients. Prospective educational study. An eLearning module was developed through a conceptual framework, using the four-stage technique for skills teaching to teach clinicians how to use the CPAx. Example and test video case studies of CPAx assessments were embedded within the module. The CPAx scores for the test case studies and demographic data were recorded in a secure area of the website. Data were analysed for inter-rater reliability using intraclass correlation coefficients (ICCs) to see if an eLearning educational package facilitated consistent use of the tool. A utility and content validity questionnaire was distributed after 1 year to eLearning module registrants (n=971). This was to evaluate uptake of the CPAx in clinical practice and content validity of the CPAx from the perspective of clinical users. The module was distributed for use via professional forums (n=2) and direct contacts (n=95). Critical care clinicians. ICC of the test case studies. Between July and October 2014, 421 candidates from 15 countries registered for the eLearning module. The ICC for case one was 0.996 (95% CI 0.990 to 0.999; n=207). The ICC for case two was 0.988 (0.996 to 1.000; n=184). The CPAx has a strong total scale content validity index (s-CVI) of 0.94 and is well used. eLearning is a useful and reliable way of teaching psychomotor skills, such as the CPAx. The CPAx is a well-used measure with high content validity rated by clinicians. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  15. The ‘performativity thesis’ and its critics: towards a relational ontology of management accounting

    NARCIS (Netherlands)

    Vosselman, E.G.J.

    2014-01-01

    This paper explores accounting's mediating role in bringing theoretical statements from economics into life. It addresses the so-called performativity thesis that claims that economic theory does not just observe and explain a reality, but rather shapes, formats and performs reality. Accounting

  16. The ‘performativity thesis’ and its critics: towards a relational ontology of management accounting.

    NARCIS (Netherlands)

    Vosselman, E.G.J.

    2014-01-01

    This paper explores accounting's mediating role in bringing theoretical statements from economics into life. It addresses the so-called performativity thesis that claims that economic theory does not just observe and explain a reality, but rather shapes, formats and performs reality. Accounting

  17. A critical cluster analysis of 44 indicators of author-level performance

    DEFF Research Database (Denmark)

    Wildgaard, Lorna Elizabeth

    2015-01-01

    . Publication and citation data for 741 researchers across Astronomy, Environmental Science, Philosophy and Public Health was collected in Web of Science (WoS). Forty-four indicators of individual performance were computed using the data. A two-step cluster analysis using IBM SPSS version 22 was performed...

  18. Critical force during tethered swimming for the evaluation of aerobic capacity and prediction of performances in freestyle swimming

    OpenAIRE

    Marcelo Papoti; Ricardo Vitório; Gustavo Gomes Araújo; Luiz Eduardo Barreto Martins; Sérgio Augusto Cunha; Claudio Alexandre Gobatto

    2010-01-01

    The present study investigated the relationship of critical force (Fcrit) with lactate threshold (LLNA) and the intensity corresponding to VO2max (iVO2max) in tethered swimming (TS), and their correlation with maximal performance in 400-m (V400) and 30-min (VT30) freestyle swimming (FS). Seven swimmers were submitted to a TS incremental test for the determination of LLNA and iVO2max. For the determination of Fcrit, the swimmers performed four exercises to exhaustion at intensities (F) corresp...

  19. Superplasticizer function and sorption in high performance cement based grouts

    International Nuclear Information System (INIS)

    Onofrei, M.; Gray, M.N.; Roe, L.H.

    1991-08-01

    This report describes laboratory studies undertaken to determine interactions between the main components of high-performance cement-based grout. These interactions were studied with the grouts in both their unset and hardened states with the specific intention of determining the following: the mechanistic function of superplasticizer; the phase of residence of the superplasticizer in hardened materials; and the permanence of the superplasticizer in hardened grouts. In unset pastes attempts were made to extract superplasticizer by mechanical processes. In hardened grout the superplasticizer was leached from the grouts. A microautoradiographic method was developed to investigate the phases of residence of superplasticizer in hardened grouts and confirm the inferences from the leaching studies. In hardened grout the superplasticizer was located on the hydrated phases formed during the early stages of cement hydration. These include tricalcium aluminate hydrates and tricalcium silicate phases. There is some tendency for the superplasticizer to sorb on ettringite. The presence of superplasticizer did not coincide with the locations of unreacted silica fume and high silica content phases such as C 2 S-H. The observations explain the findings of the studies of unset pastes which also showed that the sorption of superplasticizer is likely to be enhanced with increased mixing water content and, hence, distribution in and exposure to the hydration reaction surfaces in the grout. Superplasticizer can be leached in very small quantities from the hardened grouts. Rapid release takes place from the unsorbed superplasticizer contained in the accessible pore space. Subsequent release likely occurs with dissolution of the cement phases and the exposure of isolated pores to groundwater. (au) (37 refs.)

  20. CRITICAL FACTORS IN OUTSOURCING OF ACCOUNTING FUNCTIONS IN MALAYSIAN SMALL MEDIUM-SIZED ENTERPRISES (SMEs

    Directory of Open Access Journals (Sweden)

    Magiswary Dorasamy

    2010-01-01

    Full Text Available The challenges that business face in sustaining competitive advantage in the corporate world have become a major concern. Businesses are adopting cutting-edge technologies and best practices to cope with rapid, global changes. Various business functions are being reengineered for this purpose. Accounting functions play an important role in helping businesses to maintain competitive advantage. However, some small and medium-sized enterprises (SMEs face problems handling fundamental accounting functions. This is predominantly because of their lack of expertise; accounting functions require not only knowledge of generally accepted accounting rules or tax regulations but also the expertise needed to apply the rules in a given business environment (Everaert, Sarens and Rommel, 2006. This paper offers some insight on the outsourcing of accounting functions as there is paucity of data in this area in the context of Malaysia. Essentially, it presents empirical evidence regarding Malaysian SMEs' accounting outsourcing practices. A survey of SMEs was conducted to identify the overall outsourcing landscape as it relates to accounting and third-party organisations. The factors that contribute to the decision to outsource accounting functions are analysed. The study reveals a significant relationship between outsourcing accounting functions and two contributing factors, risks and operation management.

  1. Critical Conditions for Liquid Chromatography of Statistical Copolymers: Functionality Type and Composition Distribution Characterization by UP-LCCC/ESI-MS.

    Science.gov (United States)

    Epping, Ruben; Panne, Ulrich; Falkenhagen, Jana

    2017-02-07

    Statistical ethylene oxide (EO) and propylene oxide (PO) copolymers of different monomer compositions and different average molar masses additionally containing two kinds of end groups (FTD) were investigated by ultra high pressure liquid chromatography under critical conditions (UP-LCCC) combined with electrospray ionization time-of flight mass spectrometry (ESI-TOF-MS). Theoretical predictions of the existence of a critical adsorption point (CPA) for statistical copolymers with a given chemical and sequence distribution1 could be studied and confirmed. A fundamentally new approach to determine these critical conditions in a copolymer, alongside the inevitable chemical composition distribution (CCD), with mass spectrometric detection, is described. The shift of the critical eluent composition with the monomer composition of the polymers was determined. Due to the broad molar mass distribution (MMD) and the presumed existence of different end group functionalities as well as monomer sequence distribution (MSD), gradient separation only by CCD was not possible. Therefore, isocratic separation conditions at the CPA of definite CCD fractions were developed. Although the various present distributions partly superimposed the separation process, the goal of separation by end group functionality was still achieved on the basis of the additional dimension of ESI-TOF-MS. The existence of HO-H besides the desired allylO-H end group functionalities was confirmed and their amount estimated. Furthermore, indications for a MSD were found by UPLC/MS/MS measurements. This approach offers for the first time the possibility to obtain a fingerprint of a broad distributed statistical copolymer including MMD, FTD, CCD, and MSD.

  2. Crew workload-management strategies - A critical factor in system performance

    Science.gov (United States)

    Hart, Sandra G.

    1989-01-01

    This paper reviews the philosophy and goals of the NASA/USAF Strategic Behavior/Workload Management Program. The philosophical foundation of the program is based on the assumption that an improved understanding of pilot strategies will clarify the complex and inconsistent relationships observed among objective task demands and measures of system performance and pilot workload. The goals are to: (1) develop operationally relevant figures of merit for performance, (2) quantify the effects of strategic behaviors on system performance and pilot workload, (3) identify evaluation criteria for workload measures, and (4) develop methods of improving pilots' abilities to manage workload extremes.

  3. Flow-Boiling Critical Heat Flux Experiments Performed in Reduced Gravity

    Science.gov (United States)

    Hasan, Mohammad M.; Mudawar, Issam

    2005-01-01

    Poor understanding of flow boiling in microgravity has recently emerged as a key obstacle to the development of many types of power generation and advanced life support systems intended for space exploration. The critical heat flux (CHF) is perhaps the most important thermal design parameter for boiling systems involving both heatflux-controlled devices and intense heat removal. Exceeding the CHF limit can lead to permanent damage, including physical burnout of the heat-dissipating device. The importance of the CHF limit creates an urgent need to develop predictive design tools to ensure both the safe and reliable operation of a two-phase thermal management system under the reduced-gravity (like that on the Moon and Mars) and microgravity environments of space. At present, very limited information is available on flow-boiling heat transfer and the CHF under these conditions.

  4. The performance of flash glucose monitoring in critically ill patients with diabetes.

    Science.gov (United States)

    Ancona, Paolo; Eastwood, Glenn M; Lucchetta, Luca; Ekinci, Elif I; Bellomo, Rinaldo; Mårtensson, Johan

    2017-06-01

    Frequent glucose monitoring may improve glycaemic control in critically ill patients with diabetes. We aimed to assess the accuracy of a novel subcutaneous flash glucose monitor (FreeStyle Libre [Abbott Diabetes Care]) in these patients. We applied the FreeStyle Libre sensor to the upper arm of eight patients with diabetes in the intensive care unit and obtained hourly flash glucose measurements. Duplicate recordings were obtained to assess test-retest reliability. The reference glucose level was measured in arterial or capillary blood. We determined numerical accuracy using Bland- Altman methods, the mean absolute relative difference (MARD) and whether the International Organization for Standardization (ISO) and Clinical and Laboratory Standards Institute Point of Care Testing (CLSI POCT) criteria were met. Clarke error grid (CEG) and surveillance error grid (SEG) analyses were used to determine clinical accuracy. We compared 484 duplicate flash glucose measurements and observed a Pearson correlation coefficient of 0.97 and a coefficient of repeatability of 1.6 mmol/L. We studied 185 flash readings paired with arterial glucose levels, and 89 paired with capillary glucose levels. Using the arterial glucose level as the reference, we found a mean bias of 1.4 mmol/L (limits of agreement, -1.7 to 4.5 mmol/L). The MARD was 14% (95% CI, 12%-16%) and the proportion of measurements meeting ISO and CLSI POCT criteria was 64.3% and 56.8%, respectively. The proportions of values within a low-risk zone on CEG and SEG analyses were 97.8% and 99.5%, respectively. Using capillary glucose levels as the reference, we found that numerical and clinical accuracy were lower. The subcutaneous FreeStyle Libre blood glucose measurement system showed high test-retest reliability and acceptable accuracy when compared with arterial blood glucose measurement in critically ill patients with diabetes.

  5. Critical Reflections on Performativity and 'Un/Doing' Gender and Sexuality in Talk

    DEFF Research Database (Denmark)

    McIlvenny, Paul

    2002-01-01

    'turn' is most often traceable in the first instance to the work of the feminist philosopher Judith Butler. Butler’s (1990) troubling of how we think of gender and identity has worked through into many fields, including literary studies (Sedgwick 1993c), performance theory (Parker & Sedgwick 1995a...... of 'doing', particularly of gender and sexuality, in studies of conversation and talk-in-interaction are similar to and different from the notion of 'performativity' in the work of Judith Butler. I refer not only to her argument that gender identity "is performatively constituted by the very ‘expressions...... of the productive challenge posed by feminist and queer theories that conceive of gender (and sexuality) as something we ‘do’, not ‘are’. This view is representative of the ‘performative turn’ that can be traced in many fields and disciplines, with distinctive histories and trajectories. The source of this recent...

  6. Pulmonary and Critical Care In-Service Training Examination Score as a Predictor of Board Certification Examination Performance.

    Science.gov (United States)

    Kempainen, Robert R; Hess, Brian J; Addrizzo-Harris, Doreen J; Schaad, Douglas C; Scott, Craig S; Carlin, Brian W; Shaw, Robert C; Duhigg, Lauren; Lipner, Rebecca S

    2016-04-01

    Most trainees in combined pulmonary and critical care medicine fellowship programs complete in-service training examinations (ITEs) that test knowledge in both disciplines. Whether ITE scores predict performance on the American Board of Internal Medicine Pulmonary Disease Certification Examination and Critical Care Medicine Certification Examination is unknown. To determine whether pulmonary and critical care medicine ITE scores predict performance on subspecialty board certification examinations independently of trainee demographics, program director competency ratings, fellowship program characteristics, and prior medical knowledge assessments. First- and second-year fellows who were enrolled in the study between 2008 and 2012 completed a questionnaire encompassing demographics and fellowship training characteristics. These data and ITE scores were matched to fellows' subsequent scores on subspecialty certification examinations, program director ratings, and previous scores on their American Board of Internal Medicine Internal Medicine Certification Examination. Multiple linear regression and logistic regression were used to identify independent predictors of subspecialty certification examination scores and likelihood of passing the examinations, respectively. Of eligible fellows, 82.4% enrolled in the study. The ITE score for second-year fellows was matched to their certification examination scores, which yielded 1,484 physicians for pulmonary disease and 1,331 for critical care medicine. Second-year fellows' ITE scores (β = 0.24, P ITE odds ratio, 1.12 [95% confidence interval, 1.07-1.16]; Internal Medicine Certification Examination odds ratio, 1.01 [95% confidence interval, 1.01-1.02]). Similar results were obtained for predicting Critical Care Medicine Certification Examination scores and for passing the examination. The predictive value of ITE scores among first-year fellows on the subspecialty certification examinations was comparable to second

  7. New breathing functions for the transverse breathing crack of the cracked rotor system: Approach for critical and subcritical harmonic analysis

    Science.gov (United States)

    Al-Shudeifat, Mohammad A.; Butcher, Eric A.

    2011-01-01

    The actual breathing mechanism of the transverse breathing crack in the cracked rotor system that appears due to the shaft weight is addressed here. As a result, the correct time-varying area moments of inertia for the cracked element cross-section during shaft rotation are also determined. Hence, two new breathing functions are identified to represent the actual breathing effect on the cracked element stiffness matrix. The new breathing functions are used in formulating the time-varying finite element stiffness matrix of the cracked element. The finite element equations of motion are then formulated for the cracked rotor system and solved via harmonic balance method for response, whirl orbits and the shift in the critical and subcritical speeds. The analytical results of this approach are compared with some previously published results obtained using approximate formulas for the breathing mechanism. The comparison shows that the previously used breathing function is a weak model for the breathing mechanism in the cracked rotor even for small crack depths. The new breathing functions give more accurate results for the dynamic behavior of the cracked rotor system for a wide range of the crack depths. The current approach is found to be efficient for crack detection since the critical and subcritical shaft speeds, the unique vibration signature in the neighborhood of the subcritical speeds and the sensitivity to the unbalance force direction all together can be utilized to detect the breathing crack before further damage occurs.

  8. Recycling high-performance carbon fiber reinforced polymer composites using sub-critical and supercritical water

    Science.gov (United States)

    Knight, Chase C.

    Carbon fiber reinforced plastics (CFRP) are composite materials that consist of carbon fibers embedded in a polymer matrix, a combination that yields materials with properties exceeding the individual properties of each component. CFRP have several advantages over metals: they offer superior strength to weight ratios and superior resistance to corrosion and chemical attack. These advantages, along with continuing improvement in manufacturing processes, have resulted in rapid growth in the number of CFRP products and applications especially in the aerospace/aviation, wind energy, automotive, and sporting goods industries. Due to theses well-documented benefits and advancements in manufacturing capabilities, CFRP will continue to replace traditional materials of construction throughout several industries. However, some of the same properties that make CFRP outstanding materials also pose a major problem once these materials reach the end of service life. They become difficult to recycle. With composite consumption in North America growing by almost 5 times the rate of the US GDP in 2012, this lack of recyclability is a growing concern. As consumption increases, more waste will inevitably be generated. Current composite recycling technologies include mechanical recycling, thermal processing, and chemical processing. The major challenge of CFRP recycling is the ability to recover materials of high-value and preserve their properties. To this end, the most suitable technology is chemical processing, where the polymer matrix can be broken down and removed from the fiber, with limited damage to the fibers. This can be achieved using high concentration acids, but such a process is undesirable due to the toxicity of such materials. A viable alternative to acid is water in the sub-critical and supercritical region. Under these conditions, the behavior of this abundant and most environmentally friendly solvent resembles that of an organic compound, facilitating the breakdown

  9. Critical appraisal of the Vienna consensus: performance indicators for assisted reproductive technology laboratories.

    Science.gov (United States)

    Lopez-Regalado, María Luisa; Martínez-Granados, Luis; González-Utor, Antonio; Ortiz, Nereyda; Iglesias, Miriam; Ardoy, Manuel; Castilla, Jose A

    2018-05-24

    The Vienna consensus, based on the recommendations of an expert panel, has identified 19 performance indicators for assisted reproductive technology (ART) laboratories. Two levels of reference values are established for these performance indicators: competence and benchmark. For over 10 years, the Spanish embryology association (ASEBIR) has participated in the definition and design of ART performance indicators, seeking to establish specific guidelines for ART laboratories to enhance quality, safety and patient welfare. Four years ago, ASEBIR took part in an initiative by AENOR, the Spanish Association for Standardization and Certification, to develop a national standard in this field (UNE 17900:2013 System of quality management for assisted reproduction laboratories), extending the former requirements, based on ISO 9001, to include performance indicators. Considering the experience acquired, we discuss various aspects of the Vienna consensus and consider certain discrepancies in performance indicators between the consensus and UNE 179007:2013, and analyse the definitions, methodology and reference values used. Copyright © 2018. Published by Elsevier Ltd.

  10. Critical heat flux and post-critical heat flux performance of a 6-m, 37-element fully segmented bundle cooled by Freon-12

    International Nuclear Information System (INIS)

    Nickerson, J.R.

    1982-05-01

    A 6-m, 37-element, electrically heated bundle with full end plate simulation, cooled by Freon-12, has been tested for CHF (critical heat flux) and post-CHF conditions in the MR-3 Freon loop. The bundle was tested in a horizontal attitude and had a uniform axial heat flux distribution and radial heat flux depression. A total of 110 CHF points have been collected over the following range of water equivalent conditions: exit pressure 8.27 - 11.03 MPa, mass flux 1.38 - 8.14 Mg.m -2 .s -1 , inlet subcooling 0 - 500 kJ.kg -1 , outlet quality 10% - 37%. The data have been correlated on both a systems and local conditions basis over a limited mass flux range to within 2.8% rms. Significant CHF increases over smooth bundle results have been observed along with significant CHF improvement over a two end plate bundle simulation in the lower mass flux ranges. A satisfactory axial drypatch spreading correlation has been determined and extensive drypatch wall superheat mapping has been performed

  11. Performance Measurements, Critical Facts to Business Growth – Exemplification on Automotive Industry

    Directory of Open Access Journals (Sweden)

    Andreea Ileana ZAMFIR

    2012-12-01

    Full Text Available An important consideration in the process of modeling business processes is that in order to improve, you must define the current state of work. Accordingly, the general argument for business growth based on performance measurement is that in order to improve the process in the future, you must know how activities are conducted in the present. The article presents the key elements of performance measurements in relation to business growth, taking also into account main challenges and obstacles. The author based the research upon a larger study of increasing performance, developed inside four companies from an extended supply chain in automotive industry, relating the theoretical discoveries in the field with the real business experience.

  12. Work Functioning Among Firefighters: A Comparison Between Self-Reported Limitations and Functional Task Performance.

    Science.gov (United States)

    MacDermid, Joy C; Tang, Kenneth; Sinden, Kathryn E; D'Amico, Robert

    2018-05-25

    Purpose Performance-based and disease indicators have been widely studied in firefighters; self-reported work role limitations have not. The aim of this study was to describe the distributions and correlations of a generic self-reported Work Limitations Questionnaire (WLQ-26) and firefighting-specific task performance-based tests. Methods Active firefighters from the City of Hamilton Fire Services (n = 293) were recruited. Participants completed the WLQ-26 to quantify on-the-job difficulties over five work domains: work scheduling (4 items), output demands (7 items), physical demands (8 items), mental demands (4 items), and social demands (3 items). A subset of participants (n = 149) were also assessed on hose drag and stair climb with a high-rise pack performance-based tests. Descriptive statistics and correlations were used to compare item/subscale performance; and to describe the inter-relationships between tests. Results The mean WLQ-26 item scores (/5) ranged from 4.1 to 4.4 (median = 5 for all items); most firefighters (54.5-80.5%) selected "difficult none of the time" response option on all items. A substantial ceiling effect was observed across all five WLQ-26 subscales as 44.0-55.6% were in the highest category. Subscale means ranged from 61.8 (social demands) to 78.7 (output demands and physical demands). Internal consistency exceeded 0.90 on all subscales. For the hose drag task, the mean time-to-completion was 48.0 s (SD = 14.5; range 20.4-95.0). For the stair climb task, the mean time-to-completion was 76.7 s (SD = 37.2; range 21.0-218.0). There were no significant correlations between self-report work limitations and performance of firefighting tasks. Conclusions The WLQ-26 measured five domains, but had ceiling effects in firefighters. Performance-based testing showed wider score range, lacked ceiling effects and did not correlate to the WLQ-26. A firefighter-specific, self-report role functioning scale may be needed to identify

  13. Role of renal function in risk assessment of target non-attainment after standard dosing of meropenem in critically ill patients: a prospective observational study.

    Science.gov (United States)

    Ehmann, Lisa; Zoller, Michael; Minichmayr, Iris K; Scharf, Christina; Maier, Barbara; Schmitt, Maximilian V; Hartung, Niklas; Huisinga, Wilhelm; Vogeser, Michael; Frey, Lorenz; Zander, Johannes; Kloft, Charlotte

    2017-10-21

    Severe bacterial infections remain a major challenge in intensive care units because of their high prevalence and mortality. Adequate antibiotic exposure has been associated with clinical success in critically ill patients. The objective of this study was to investigate the target attainment of standard meropenem dosing in a heterogeneous critically ill population, to quantify the impact of the full renal function spectrum on meropenem exposure and target attainment, and ultimately to translate the findings into a tool for practical application. A prospective observational single-centre study was performed with critically ill patients with severe infections receiving standard dosing of meropenem. Serial blood samples were drawn over 4 study days to determine meropenem serum concentrations. Renal function was assessed by creatinine clearance according to the Cockcroft and Gault equation (CLCR CG ). Variability in meropenem serum concentrations was quantified at the middle and end of each monitored dosing interval. The attainment of two pharmacokinetic/pharmacodynamic targets (100%T >MIC , 50%T >4×MIC ) was evaluated for minimum inhibitory concentration (MIC) values of 2 mg/L and 8 mg/L and standard meropenem dosing (1000 mg, 30-minute infusion, every 8 h). Furthermore, we assessed the impact of CLCR CG on meropenem concentrations and target attainment and developed a tool for risk assessment of target non-attainment. Large inter- and intra-patient variability in meropenem concentrations was observed in the critically ill population (n = 48). Attainment of the target 100%T >MIC was merely 48.4% and 20.6%, given MIC values of 2 mg/L and 8 mg/L, respectively, and similar for the target 50%T >4×MIC . A hyperbolic relationship between CLCR CG (25-255 ml/minute) and meropenem serum concentrations at the end of the dosing interval (C 8h ) was derived. For infections with pathogens of MIC 2 mg/L, mild renal impairment up to augmented renal function was

  14. Safety critical systems handbook a straightforward guide to functional safety : IEC 61508 (2010 edition) and related standards

    CERN Document Server

    Smith, David J

    2010-01-01

    Electrical, electronic and programmable electronic systems increasingly carry out safety functions to guard workers and the public against injury or death and the environment against pollution. The international functional safety standard IEC 61508 was revised in 2010, and this is the first comprehensive guide available to the revised standard. As functional safety is applicable to many industries, this book will have a wide readership beyond the chemical and process sector, including oil and gas, power generation, nuclear, aircraft, and automotive industries, plus project, instrumentation, design, and control engineers. * The only comprehensive guide to IEC 61508, updated to cover the 2010 amendments, that will ensure engineers are compliant with the latest process safety systems design and operation standards* Helps readers understand the process required to apply safety critical systems standards* Real-world approach helps users to interpret the standard, with case studies and best practice design examples...

  15. Assessing Risk-Based Performance Indicators in Safety-Critical Systems for Nuclear Power Plants

    OpenAIRE

    TONT Gabriela

    2011-01-01

    The paper proposes framework for a multidisciplinary nuclear risk and safety assessment by modeling uncertainty and combining diverse evidence provided in such a way that it could be used to represent an entire argument about a system's dependability. The identified safety issues are being treated by means of probabilistic safety assessment (PSA). The behavior simulation of power plant in thepresence of risk factors is analyzed from the vulnerability, risk and functional safety viewpoints, hi...

  16. Mapping of control functions of critical systems by reachability analysis in a network of communicating automata

    International Nuclear Information System (INIS)

    Lemattre, Thibault

    2013-01-01

    The design of operational control architectures is a very important step of the design of energy production systems. This step consists in mapping the functional architecture of the system onto its hardware architecture while respecting capacity and safety constraints, i.e. in allocating control functions to a set of controllers while respecting these constraints. The work presented in this thesis presents: i) a formalization of the data and constraints of the function allocation problem; ii) a mapping method, by reachability analysis, based on a request/response mechanism in a network of communicating automata with integer variables; iii) a comparison between this method and a resolution method by integer linear programming. The results of this work have been validated on examples of actual size and open the way to the coupling between reachability analysis and integer linear programming for the resolution of satisfaction problems for non-linear constraint systems. (author)

  17. Space, the final frontier: A critical review of recent experiments performed in microgravity.

    Science.gov (United States)

    Vandenbrink, Joshua P; Kiss, John Z

    2016-02-01

    Space biology provides an opportunity to study plant physiology and development in a unique microgravity environment. Recent space studies with plants have provided interesting insights into plant biology, including discovering that plants can grow seed-to-seed in microgravity, as well as identifying novel responses to light. However, spaceflight experiments are not without their challenges, including limited space, limited access, and stressors such as lack of convection and cosmic radiation. Therefore, it is important to design experiments in a way to maximize the scientific return from research conducted on orbiting platforms such as the International Space Station. Here, we provide a critical review of recent spaceflight experiments and suggest ways in which future experiments can be designed to improve the value and applicability of the results generated. These potential improvements include: utilizing in-flight controls to delineate microgravity versus other spaceflight effects, increasing scientific return via next-generation sequencing technologies, and utilizing multiple genotypes to ensure results are not unique to one genetic background. Space experiments have given us new insights into plant biology. However, to move forward, special care should be given to maximize science return in understanding both microgravity itself as well as the combinatorial effects of living in space. Copyright © 2015. Published by Elsevier Ireland Ltd.

  18. On the Temporal and Functional Origin of L2 Disadvantages in Speech Production: A Critical Review

    Science.gov (United States)

    Runnqvist, Elin; Strijkers, Kristof; Sadat, Jasmin; Costa, Albert

    2011-01-01

    Despite a large amount of psycholinguistic research devoted to the issue of processing differences between a first and a second language, there is no consensus regarding the locus where these emerge or the mechanism behind them. The aim of this article is to briefly examine both the behavioral and neuroscientific evidence in order to critically assess three hypotheses that have been put forward in the literature to explain such differences: the weaker links, executive control, and post-lexical accounts. We conclude that (a) while all stages of processing are likely to be slowed down when speaking in an L2 compared to an L1, the differences seem to originate at a lexical stage; and (b) frequency of use seems to be the variable mainly responsible for these bilingual processing disadvantages. PMID:22203812

  19. Critical assessment of three high performance liquid chromatography analytical methods for food carotenoid quantification

    NARCIS (Netherlands)

    Dias, M.G.; Oliveira, L.; Camoes, M.F.G.F.C.; Nunes, B.; Versloot, P.; Hulshof, P.J.M.

    2010-01-01

    Three sets of extraction/saponification/HPLC conditions for food carotenoid quantification were technically and economically compared. Samples were analysed for carotenoids a-carotene, ß-carotene, ß-cryptoxanthin, lutein, lycopene, and zeaxanthin. All methods demonstrated good performance in the

  20. The impact of environmental conditions on human performance: A critical review of the literature. Volume 2

    International Nuclear Information System (INIS)

    Echeverria, D.; Barnes, V.; Bittner, A.

    1994-09-01

    The Battelle Human Affairs Research Centers (HARC) conducted a comprehensive review of the technical literature regarding the impact of environmental conditions on human performance applicable to nuclear power plant workers. The environmental conditions considered were vibration, noise, heat, cold, and light. Research staff identified potential human performance deficits along a continuum of increasing occupational exposure, ranging from deficits that occur at low exposures to deficits that occur at high exposures. Specific deficits were included in the review if scientists demonstrated the exposure caused an effect, using sound methodology. The levels associated with each deficit were then compared to the protection afforded by existing occupational exposure standards. Volume 2 presents several conclusions regarding the applicability of the research literature to environmental conditions in nuclear power plants. The findings presented suggest that occupational standards for vibration, noise, and heat, which were developed to protect health, are inadequate for preventing deficits in cognitive or motor performance in tasks likely to be performed in nuclear power plants. Also, there is little information in the literature on simultaneous conditions; for example, the effects of simultaneous exposure to heat and noise on cognition require more research. As many exposures in nuclear power plants will be simultaneous, this limitation should be kept in mind when using Volume 1

  1. Effects of cell asymmetry on the performance of a large heterogeneous critical assembly

    International Nuclear Information System (INIS)

    Scholtyssek, W.; Humbert, G.; Martini, M.; Norvez, G.

    1981-09-01

    Calculations were performed to investigate asymmetry effects observed in the RACINE reference configuration. The perturbation sources -material shifts in fissile rodlet cells- were identified and influences on various experimental parameters were estimated. Improvements of the relatively simple methods used in this work could lead to applications, considering similar effects, in project calculations for large power reactor cores

  2. Praise in Public, Criticize in Private? An Assessment of Performance Feedback Transparency in a Classroom Setting

    Science.gov (United States)

    Seevers, Matthew T.; Rowe, William J.; Skinner, Steven J.

    2014-01-01

    Conventional wisdom in sales management encourages public delivery of positive feedback, and private delivery of negative feedback. In stark contrast, U.S. educators typically provide all performance feedback in relative (if not strict) privacy to comply with the Family Educational Rights and Privacy Act (FERPA). To investigate this discrepancy,…

  3. Critical factors in the empirical performance of temporal difference and evolutionary methods for reinforcement learning

    NARCIS (Netherlands)

    Whiteson, S.; Taylor, M.E.; Stone, P.

    2010-01-01

    Temporal difference and evolutionary methods are two of the most common approaches to solving reinforcement learning problems. However, there is little consensus on their relative merits and there have been few empirical studies that directly compare their performance. This article aims to address

  4. Creating a Critical Mass Eliminates the Effects of Stereotype Threat on Women's Mathematical Performance

    Science.gov (United States)

    Pennington, Charlotte R.; Heim, Derek

    2016-01-01

    Background: Women in mathematical domains may become attuned to situational cues that signal a discredited social identity, contributing to their lower achievement and underrepresentation. Aim: This study examined whether heightened in-group representation alleviates the effects of stereotype threat on women's mathematical performance. It further…

  5. Lessons from High-Performing Hispanic Schools: Creating Learning Communities. Critical Issues in Educational Leadership Series.

    Science.gov (United States)

    Reyes, Pedro, Ed.; Scribner, Jay D., Ed.; Scribner, Alicia Paredes, Ed.

    The current poor condition of education for Hispanic students need not exist. This book reports on high-performing schools along the Texas-Mexico border that have achieved schoolwide success by creating communities of learners. Three elementary, three middle, and two high schools in the border region were selected for study based on the following…

  6. Literacy, Play and Globalization: Converging Imaginaries in Children's Critical and Cultural Performances. Routledge Research in Education

    Science.gov (United States)

    Medina, Carmen L.; Wohlwend, Karen E.

    2014-01-01

    This book takes on current perspectives on children's relationships to literacy, media, childhood, markets and transtionalism in converging global worlds. It introduces the idea of multi-sited imaginaries to explain how children's media and literacy performances shape and are shaped by shared visions of communities that we collectively imagine,…

  7. C-terminus glycans with critical functional role in the maturation of secretory glycoproteins.

    Directory of Open Access Journals (Sweden)

    Daniela Cioaca

    Full Text Available The N-glycans of membrane glycoproteins are mainly exposed to the extracellular space. Human tyrosinase is a transmembrane glycoprotein with six or seven bulky N-glycans exposed towards the lumen of subcellular organelles. The central active site region of human tyrosinase is modeled here within less than 2.5 Å accuracy starting from Streptomyces castaneoglobisporus tyrosinase. The model accounts for the last five C-terminus glycosylation sites of which four are occupied and indicates that these cluster in two pairs--one in close vicinity to the active site and the other on the opposite side. We have analyzed and compared the roles of all tyrosinase N-glycans during tyrosinase processing with a special focus on the proximal to the active site N-glycans, s6:N337 and s7:N371, versus s3:N161 and s4:N230 which decorate the opposite side of the domain. To this end, we have constructed mutants of human tyrosinase in which its seven N-glycosylation sites were deleted. Ablation of the s6:N337 and s7:N371 sites arrests the post-translational productive folding process resulting in terminally misfolded mutants subjected to degradation through the mannosidase driven ERAD pathway. In contrast, single mutants of the other five N-glycans located either opposite to the active site or into the N-terminus Cys1 extension of tyrosinase are temperature-sensitive mutants and recover enzymatic activity at the permissive temperature of 31°C. Sites s3 and s4 display selective calreticulin binding properties. The C-terminus sites s7 and s6 are critical for the endoplasmic reticulum retention and intracellular disposal. Results herein suggest that individual N-glycan location is critical for the stability, regional folding control and secretion of human tyrosinase and explains some tyrosinase gene missense mutations associated with oculocutaneous albinism type I.

  8. Thermoelectric performance of functionalized Sc2C MXenes

    KAUST Repository

    Kumar, S.

    2016-07-05

    Functionalization of the MXene Sc2C, which has the rare property to realize semiconducting states for various functionalizations including O, F, and OH, is studied with respect to the electronic and thermal behavior. The lowest lattice thermal conductivity is obtained for OH functionalization and an additional 30% decrease can be achieved by confining the phonon mean free path to 100 nm. Despite a relatively low Seebeck coefficient, Sc2C(OH)2 is a candidate for intermediate-temperature thermoelectric applications due to compensation by a high electrical conductivity and very low lattice thermal conductivity.

  9. Thermoelectric performance of functionalized Sc2C MXenes

    KAUST Repository

    Kumar, S.; Schwingenschlö gl, Udo

    2016-01-01

    Functionalization of the MXene Sc2C, which has the rare property to realize semiconducting states for various functionalizations including O, F, and OH, is studied with respect to the electronic and thermal behavior. The lowest lattice thermal conductivity is obtained for OH functionalization and an additional 30% decrease can be achieved by confining the phonon mean free path to 100 nm. Despite a relatively low Seebeck coefficient, Sc2C(OH)2 is a candidate for intermediate-temperature thermoelectric applications due to compensation by a high electrical conductivity and very low lattice thermal conductivity.

  10. Performance of exchange-correlation functionals in density functional theory calculations for liquid metal: A benchmark test for sodium

    Science.gov (United States)

    Han, Jeong-Hwan; Oda, Takuji

    2018-04-01

    The performance of exchange-correlation functionals in density-functional theory (DFT) calculations for liquid metal has not been sufficiently examined. In the present study, benchmark tests of Perdew-Burke-Ernzerhof (PBE), Armiento-Mattsson 2005 (AM05), PBE re-parameterized for solids, and local density approximation (LDA) functionals are conducted for liquid sodium. The pair correlation function, equilibrium atomic volume, bulk modulus, and relative enthalpy are evaluated at 600 K and 1000 K. Compared with the available experimental data, the errors range from -11.2% to 0.0% for the atomic volume, from -5.2% to 22.0% for the bulk modulus, and from -3.5% to 2.5% for the relative enthalpy depending on the DFT functional. The generalized gradient approximation functionals are superior to the LDA functional, and the PBE and AM05 functionals exhibit the best performance. In addition, we assess whether the error tendency in liquid simulations is comparable to that in solid simulations, which would suggest that the atomic volume and relative enthalpy performances are comparable between solid and liquid states but that the bulk modulus performance is not. These benchmark test results indicate that the results of liquid simulations are significantly dependent on the exchange-correlation functional and that the DFT functional performance in solid simulations can be used to roughly estimate the performance in liquid simulations.

  11. Surface water retardation around single-chain polymeric nanoparticles: critical for catalytic function?

    Science.gov (United States)

    Stals, Patrick J M; Cheng, Chi-Yuan; van Beek, Lotte; Wauters, Annelies C; Palmans, Anja R A; Han, Songi; Meijer, E W

    2016-03-01

    A library of water-soluble dynamic single-chain polymeric nanoparticles (SCPN) was prepared using a controlled radical polymerisation technique followed by the introduction of functional groups, including probes at targeted positions. The combined tools of electron paramagnetic resonance (EPR) and Overhauser dynamic nuclear polarization (ODNP) reveal that these SCPNs have structural and surface hydration properties resembling that of enzymes.

  12. Which plant traits respond to aridity? A critical step to assess functional diversity in Mediterranean drylands

    Czech Academy of Sciences Publication Activity Database

    Nunes, A.; Köbel, M.; Pihno, P.; Matos, P.; de Bello, Francesco; Correia, O.; Branquinho, C.

    2017-01-01

    Roč. 239, MAY 28 2017 (2017), s. 176-184 ISSN 0168-1923 Institutional support: RVO:67985939 Keywords : Annual plants * Climatic gradient * Functional dispersion Subject RIV: EH - Ecology, Behaviour OBOR OECD: Ecology Impact factor: 3.887, year: 2016

  13. Impaired physical function, loss of muscle mass and assessment of biomechanical properties in critical ill patients

    DEFF Research Database (Denmark)

    Poulsen, Jesper Brøndum

    2012-01-01

    Intensive care unit (ICU) admission is associated with muscle weakness and ICU survivors report sustained limitation of physical capacity for years after discharge. Limited information is available on the underlying biomechanical properties responsible for this muscle function impairment. A plaus......Intensive care unit (ICU) admission is associated with muscle weakness and ICU survivors report sustained limitation of physical capacity for years after discharge. Limited information is available on the underlying biomechanical properties responsible for this muscle function impairment....... A plausible contributor to the accentuated catabolic drive in ICU patients is a synergistic response to inflammation and inactivity leading to loss of muscle mass. As these entities are predominantly present in the early phase of ICU stay, interventions employed during this time frame may exhibit the greatest...... potential to counteract loss of muscle mass. Despite the obvious clinical significance of muscle atrophy for the functional impairment observed in ICU survivors, no preventive therapies have been identified as yet. The overall aim of the present dissertation is to characterize aspects of physical function...

  14. 36 CFR 1194.31 - Functional performance criteria.

    Science.gov (United States)

    2010-07-01

    ... BARRIERS COMPLIANCE BOARD ELECTRONIC AND INFORMATION TECHNOLOGY ACCESSIBILITY STANDARDS Functional... technology used by people who are deaf or hard of hearing shall be provided. (d) Where audio information is...

  15. Heart rate variability to monitor performance in elite athletes: Criticalities and avoidable pitfalls.

    Science.gov (United States)

    Lucini, Daniela; Marchetti, Ilaria; Spataro, Antonio; Malacarne, Mara; Benzi, Manuela; Tamorri, Stefano; Sala, Roberto; Pagani, Massimo

    2017-08-01

    Spectral analysis of Heart Rate Variability (HRV) is a simple, non-invasive technique that is widely used in sport to assess sympatho-vagal regulation of the heart. Its employment is increasing partly due to the rising usage of wearable devices. However data acquisition using these devices may be suboptimal because they cannot discriminate between sinus and non-sinus beats and do not record any data regarding respiratory frequency. This information is mandatory for a correct clinical interpretation. This study involved 974 elite athletes, all of them underwent a complete autonomic assessment, by way of Autoregressive HRV analysis. In 91 subjects (9% of the total population) we observed criticalities of either cardiac rhythm or respiration. Through perusal of one-lead ECG analysis we observed that 77 subjects had atrial or ventricular ectopy, i.e. conditions which impair stationarity and sinus rhythm. Running anyway autonomic nervous system analysis in this population, we observed that RR variance and raw values of LF and HF regions are significantly higher in arrhythmic subjects. In addition 14 subjects had slow (about 6 breath/min, 0.1Hz) respiration. This condition clouds the separation between LF from HF spectral regions of RR interval variability, respectively markers of the prevalent sympathetic and vagal modulation of SA node and of their synergistic interaction. Caution must be payed when assessing HRV with non-ECG wearable devices. Recording ECG signal and ensuring that respiratory rate is higher than 10 breath/min are both prerequisites for a more reliable analysis of HRV particularly in athletes. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Determination of the response function for the Portsmouth Gaseous Diffusion Plant criticality accident alarm system neutron detectors

    International Nuclear Information System (INIS)

    Tayloe, R.W. Jr.; Brown, A.S.; Dobelbower, M.C.; Woollard, J.E.

    1997-03-01

    Neutron-sensitive radiation detectors are used in the Portsmouth Gaseous Diffusion Plant's (PORTS) criticality accident alarm system (CAAS). The CAAS is composed of numerous detectors, electronics, and logic units. It uses a telemetry system to sound building evacuation horns and to provide remote alarm status in a central control facility. The ANSI Standard for a CAAS uses a free-in-air dose rate to define the detection criteria for a minimum accident-of-concern. Previously, the free-in-air absorbed dose rate from neutrons was used for determining the areal coverge of criticality detection within PORTS buildings handling fissile materials. However, the free-in-air dose rate does not accurately reflect the response of the neutron detectors in use at PORTS. Because the cost of placing additional CAAS detectors in areas of questionable coverage (based on a free-in-air absorbed dose rate) is high, the actual response function for the CAAS neutron detectors was determined. This report, which is organized into three major sections, discusses how the actual response function for the PORTS CAAS neutron detectors was determined. The CAAS neutron detectors are described in Section 2. The model of the detector system developed to facilitate calculation of the response function is discussed in Section 3. The results of the calculations, including confirmatory measurements with neutron sources, are given in Section 4

  17. Critical success factors for implementation of supply chain management in Indian small and medium enterprises and their impact on performance

    Directory of Open Access Journals (Sweden)

    Ravinder Kumar

    2015-06-01

    Full Text Available Globalization of the economy, e-business, and introduction of new technologies pose new challenges to all organizations especially for small and medium enterprises (SMEs. In this scenario, successful implementation of supply chain management (SCM can give SMEs an edge over their competitors. However, SMEs in India and other developing countries face problems in SCM implementation due to lack of resources and direction. Against this backdrop, this paper identified 13 critical success factors (CSFs for implementation of SCM in SMEs and studied their impact on performance of Indian SMEs. Top management commitment, long–term vision, focus on core strengths, devoted resources for supply chain, and development of effective SCM strategy emerged as the most pertinent CSFs. To measure improvement in performance, the authors considered different measures related to customer service and satisfaction, innovation and growth, financial performance, and internal business. Results are analysed by testing research propositions using standard statistical tools.

  18. Lean practices implementation, their criticalities and their relationships with operational responsiveness and firm performance

    OpenAIRE

    De Sanctis, Ilaria; Ciarapica, Filippo E.; Ordieres-Meré, Joaquín

    2016-01-01

    In the last few years, at European Union level, companies are facing many obstacles due to macroeconomic instability. In order to stay competitive and survive in the present world turmoil, companies must seek to new ways of reducing costs, increase the quality of the products and meet the ongoing changes in the market. Driven by the success performed by Toyota and several other organizations worldwide, a growing number of firms have been adopting Lean manufacturing practices to fulfill market...

  19. Classifying human operator functional state based on electrophysiological and performance measures and fuzzy clustering method.

    Science.gov (United States)

    Zhang, Jian-Hua; Peng, Xiao-Di; Liu, Hua; Raisch, Jörg; Wang, Ru-Bin

    2013-12-01

    The human operator's ability to perform their tasks can fluctuate over time. Because the cognitive demands of the task can also vary it is possible that the capabilities of the operator are not sufficient to satisfy the job demands. This can lead to serious errors when the operator is overwhelmed by the task demands. Psychophysiological measures, such as heart rate and brain activity, can be used to monitor operator cognitive workload. In this paper, the most influential psychophysiological measures are extracted to characterize Operator Functional State (OFS) in automated tasks under a complex form of human-automation interaction. The fuzzy c-mean (FCM) algorithm is used and tested for its OFS classification performance. The results obtained have shown the feasibility and effectiveness of the FCM algorithm as well as the utility of the selected input features for OFS classification. Besides being able to cope with nonlinearity and fuzzy uncertainty in the psychophysiological data it can provide information about the relative importance of the input features as well as the confidence estimate of the classification results. The OFS pattern classification method developed can be incorporated into an adaptive aiding system in order to enhance the overall performance of a large class of safety-critical human-machine cooperative systems.

  20. Critical Jostling

    Directory of Open Access Journals (Sweden)

    Pippin Barr

    2016-11-01

    Full Text Available Games can serve a critical function in many different ways, from serious games about real world subjects to self-reflexive commentaries on the nature of games themselves. In this essay we discuss critical possibilities stemming from the area of critical design, and more specifically Carl DiSalvo’s adversarial design and its concept of reconfiguring the remainder. To illustrate such an approach, we present the design and outcomes of two games, Jostle Bastard and Jostle Parent. We show how the games specifically engage with two previous games, Hotline Miami and Octodad: Dadliest Catch, reconfiguring elements of those games to create interactive critical experiences and extensions of the source material. Through the presentation of specific design concerns and decisions, we provide a grounded illustration of a particular critical function of videogames and hope to highlight this form as another valuable approach in the larger area of videogame criticism.

  1. High lumenal chloride in the lysosome is critical for lysosome function.

    Science.gov (United States)

    Chakraborty, Kasturi; Leung, KaHo; Krishnan, Yamuna

    2017-07-25

    Lysosomes are organelles responsible for the breakdown and recycling of cellular machinery. Dysfunctional lysosomes give rise to lysosomal storage disorders as well as common neurodegenerative diseases. Here, we use a DNA-based, fluorescent chloride reporter to measure lysosomal chloride in Caenorhabditis elegans as well as murine and human cell culture models of lysosomal diseases. We find that the lysosome is highly enriched in chloride, and that chloride reduction correlates directly with a loss in the degradative function of the lysosome. In nematodes and mammalian cell culture models of diverse lysosomal disorders, where previously only lysosomal pH dysregulation has been described, massive reduction of lumenal chloride is observed that is ~10 3 fold greater than the accompanying pH change. Reducing chloride within the lysosome impacts Ca 2+ release from the lysosome and impedes the activity of specific lysosomal enzymes indicating a broader role for chloride in lysosomal function.

  2. Data processing and critical function status display system in the nuclear power plant monitoring systems; Procesiranje podataka i prika zstanja kriticnih funkcija postrojenja u sistemima nadzora nuklrearne elektrane

    Energy Technology Data Exchange (ETDEWEB)

    Sinjeri, Lj; Plackovic, R [SOUR Rade Koncar, Zagreb (Yugoslavia)

    1984-07-01

    The Critical Function Monitoring System is a data acquisition and display system designed for effective presentation of essential nuclear plant operational data enabling supervision of the safety status of the nuclear plant by the operational staff. In this article the system functional requirements have been analysed and in accordance with the results of this analysis approach to defininf the design basis for realisation of the Critical Function Monitoring System by 'RK' equipment has been briefly described. (author)

  3. WWER-440/V-230 Confinement modernization to upgrade the critical safety function 'Containment integrity' in case of severe accident

    International Nuclear Information System (INIS)

    Sartmadjiev, A.

    1999-01-01

    In this lecture the WWER-440/V-230 confinement modernization to upgrade the critical safety function 'Containment integrity' in case of severe accident is presented. There are discussed: design limitations of the location system; consequence from these design limitations; a few confinement reconstruction concepts of this type of units worldwide; and purpose of the confinement reconstruction - to improve significantly the original design, ensuring (1) localization for all possible primary breaks and (2) limitation of the radiological consequences for the personnel, the population and the environment below the regulatory requirements

  4. Uterine NK cells are critical in shaping DC immunogenic functions compatible with pregnancy progression.

    Directory of Open Access Journals (Sweden)

    Irene Tirado-González

    Full Text Available Dendritic cell (DC and natural killer (NK cell interactions are important for the regulation of innate and adaptive immunity, but their relevance during early pregnancy remains elusive. Using two different strategies to manipulate the frequency of NK cells and DC during gestation, we investigated their relative impact on the decidualization process and on angiogenic responses that characterize murine implantation. Manipulation of the frequency of NK cells, DC or both lead to a defective decidual response characterized by decreased proliferation and differentiation of stromal cells. Whereas no detrimental effects were evident upon expansion of DC, NK cell ablation in such expanded DC mice severely compromised decidual development and led to early pregnancy loss. Pregnancy failure in these mice was associated with an unbalanced production of anti-angiogenic signals and most notably, with increased expression of genes related to inflammation and immunogenic activation of DC. Thus, NK cells appear to play an important role counteracting potential anomalies raised by DC expansion and overactivity in the decidua, becoming critical for normal pregnancy progression.

  5. Uterine NK cells are critical in shaping DC immunogenic functions compatible with pregnancy progression.

    Science.gov (United States)

    Tirado-González, Irene; González, Irene Tirado; Barrientos, Gabriela; Freitag, Nancy; Otto, Teresa; Thijssen, Victor L J L; Moschansky, Petra; von Kwiatkowski, Petra; Klapp, Burghard F; Winterhager, Elke; Bauersachs, Stefan; Blois, Sandra M

    2012-01-01

    Dendritic cell (DC) and natural killer (NK) cell interactions are important for the regulation of innate and adaptive immunity, but their relevance during early pregnancy remains elusive. Using two different strategies to manipulate the frequency of NK cells and DC during gestation, we investigated their relative impact on the decidualization process and on angiogenic responses that characterize murine implantation. Manipulation of the frequency of NK cells, DC or both lead to a defective decidual response characterized by decreased proliferation and differentiation of stromal cells. Whereas no detrimental effects were evident upon expansion of DC, NK cell ablation in such expanded DC mice severely compromised decidual development and led to early pregnancy loss. Pregnancy failure in these mice was associated with an unbalanced production of anti-angiogenic signals and most notably, with increased expression of genes related to inflammation and immunogenic activation of DC. Thus, NK cells appear to play an important role counteracting potential anomalies raised by DC expansion and overactivity in the decidua, becoming critical for normal pregnancy progression.

  6. Temporal binding function of dorsal CA1 is critical for declarative memory formation.

    Science.gov (United States)

    Sellami, Azza; Al Abed, Alice Shaam; Brayda-Bruno, Laurent; Etchamendy, Nicole; Valério, Stéphane; Oulé, Marie; Pantaléon, Laura; Lamothe, Valérie; Potier, Mylène; Bernard, Katy; Jabourian, Maritza; Herry, Cyril; Mons, Nicole; Piazza, Pier-Vincenzo; Eichenbaum, Howard; Marighetto, Aline

    2017-09-19

    Temporal binding, the process that enables association between discontiguous stimuli in memory, and relational organization, a process that enables the flexibility of declarative memories, are both hippocampus-dependent and decline in aging. However, how these two processes are related in supporting declarative memory formation and how they are compromised in age-related memory loss remain hypothetical. We here identify a causal link between these two features of declarative memory: Temporal binding is a necessary condition for the relational organization of discontiguous events. We demonstrate that the formation of a relational memory is limited by the capability of temporal binding, which depends on dorsal (d)CA1 activity over time intervals and diminishes in aging. Conversely, relational representation is successful even in aged individuals when the demand on temporal binding is minimized, showing that relational/declarative memory per se is not impaired in aging. Thus, bridging temporal intervals by dCA1 activity is a critical foundation of relational representation, and a deterioration of this mechanism is responsible for the age-associated memory impairment.

  7. The teacher is dead, long live the teacher! Performing autoethnography as critical learning

    DEFF Research Database (Denmark)

    Chemi, Tatiana

    2018-01-01

    of the reflexive practitioner's work in education? How can performance and drama ever be considered as true or truthful forms of scientific conceptualisation and communication? The author peeks in and out of the stage and within an absurdist genre of playwriting. The method used is generative and arts......-based, by means of writing blocks of short dialogues. These are put together in a dramaturgical progression that has emerged from a self-assigned obstruction: the author never mentions words related to learning, teaching, school, or education. This fixed rule unlocked the creative power of the text and words...

  8. The impact of fatigue on the non-technical skills performance of critical care air ambulance clinicians.

    Science.gov (United States)

    Myers, J A; Powell, D M C; Aldington, S; Sim, D; Psirides, A; Hathaway, K; Haney, M F

    2017-11-01

    The relationship between fatigue-related risk and impaired clinical performance is not entirely clear. Non-technical factors represent an important component of clinical performance and may be sensitive to the effects of fatigue. The hypothesis was that the sum score of overall non-technical performance is degraded by fatigue. Nineteen physicians undertook two different simulated air ambulance missions, once when rested, and once when fatigued (randomised crossover design). Trained assessors blinded to participants' fatigue status performed detailed structured assessments based on expected behaviours in four non-technical skills domains: teamwork, situational awareness, task management, and decision making. Participants also provided self-ratings of their performance. The primary endpoint was the sum score of overall non-technical performance. The main finding, the overall non-technical skills performance rating of the clinicians, was better in rested than fatigued states (mean difference with 95% CI, 2.8 [2.2-3.4]). The findings remained consistent across individual non-technical skills domains; also when controlling for an order effect and examining the impact of a number of possible covariates. There was no difference in self-ratings of clinical performance between rested and fatigued states. Non-technical performance of critical care air transfer clinicians is degraded when they are fatigued. Fatigued clinicians may fail to recognise the degree to which their performance is compromised. These findings represent risk to clinical care quality and patient safety in the dynamic and isolated environment of air ambulance transfer. © 2017 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

  9. [Burnout in Nursing Professionals Performing Overtime Workdays in Emergency and Critical Care Departments. Spain].

    Science.gov (United States)

    Cañadas-De la Fuente, Guillermo Arturo; Albendín-García, Luis; de la Fuente, Emilia Inmaculada; San Luis, Concepción; Gómez-Urquiza, José Luis; Cañadas, Gustavo Raúl

    2016-09-14

    Burnout syndrome is a disorder that seriously affects people who suffer it, the institutions in which they work and the quality of healthcare. It is of great interest to advance in burnout research for its possible prevention. The aim of this work was to study the levels of burnout syndrome in nurses of emergency department with overtime workdays and to know the relationship between burnout and personality characteristics. Multicenter cross-sectional study with a sample of 1225 emergency nurses from the Andalusian Health Service. Demographic, social and occupational variables were recorded. Burnout was assessed with Maslach Burnout Inventory and personality factors with NEO-Five Factor Inventory. Descriptive analysis of the variables, independent means hypothesis contrast and bayesian analysis were done. 44.1% of nurses who perform overtime workdays have high burnout versus a 38% for those without such overload. These differences have been also found in burnout dimensions, especially in emotional exhaustion (15.3% versus 10.8%) and depersonalization (17.9% versus 11.8%). Overtime workdays performed by emergency nurses seems to have a negative on them and it could also influence the development of burnout syndrome.

  10. Eventual sport performance level: What about the role of type of sport, perception of critical life events, and practice quality?

    Science.gov (United States)

    Toering, Tynke

    2017-01-01

    The target article describes an interesting study, which provides some challenging findings regarding athletes' pathway to excellence. The suggested links between critical life events, need for success, personal characteristics, and eventual performance level make sense from a psychodynamic perspective. This commentary will discuss some critical points related to the application of the findings in talent identification and -development programs. These are (1) the possible effect of the selection of participants on the results (including the impact of dependence on others for team sport athletes and the opportunity for multiple medal attainment), (2) a lack of detail in the description of how the athletes approached the critical life events (the perception of an event may contribute more to development than the event itself), and (3) a lack of detail in the description of the practice process throughout development. Some interesting differences were found in the motivation for and approach to practice, but little detail was given about what the athletes exactly were doing at the time. The concept of self-regulated learning may be useful in explaining how super-elite athletes action their goals through quality practice. © 2017 Elsevier B.V. All rights reserved.

  11. Human-Robot Teams Informed by Human Performance Moderator Functions

    Science.gov (United States)

    2012-08-29

    performance factors that affect the ability of a human to drive at night, which includes the eyesight of the driver, the fatigue level of the driver...where human factors are factors that affect the performance of an individual. 7 for human interaction. For instance, they explain the various human... affecting trust in human-robot interaction. Human Factors 53(5), 517-527 (2001) 35. Hart, S. G. and Staveland, L. E. Development of NASA-TLX (Task

  12. Identification and verification of critical performance dimensions. Phase 1 of the systematic process redesign of drug distribution.

    Science.gov (United States)

    Colen, Hadewig B; Neef, Cees; Schuring, Roel W

    2003-06-01

    Worldwide patient safety has become a major social policy problem for healthcare organisations. As in other organisations, the patients in our hospital also suffer from an inadequate distribution process, as becomes clear from incident reports involving medication errors. Medisch Spectrum Twente is a top primary-care, clinical, teaching hospital. The hospital pharmacy takes care of 1070 internal beds and 1120 beds in an affiliated psychiatric hospital and nursing homes. In the beginning of 1999, our pharmacy group started a large interdisciplinary research project to develop a safe, effective and efficient drug distribution system by using systematic process redesign. The process redesign includes both organisational and technological components. This article describes the identification and verification of critical performance dimensions for the design of drug distribution processes in hospitals (phase 1 of the systematic process redesign of drug distribution). Based on reported errors and related causes, we suggested six generic performance domains. To assess the role of the performance dimensions, we used three approaches: flowcharts, interviews with stakeholders and review of the existing performance using time studies and medication error studies. We were able to set targets for costs, quality of information, responsiveness, employee satisfaction, and degree of innovation. We still have to establish what drug distribution system, in respect of quality and cost-effectiveness, represents the best and most cost-effective way of preventing medication errors. We intend to develop an evaluation model, using the critical performance dimensions as a starting point. This model can be used as a simulation template to compare different drug distribution concepts in order to define the differences in quality and cost-effectiveness.

  13. Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle function

    Science.gov (United States)

    Gallagher, Thomas L.; Arribere, Joshua A.; Geurts, Paul A.; Exner, Cameron R. T.; McDonald, Kent L.; Dill, Kariena K.; Marr, Henry L.; Adkar, Shaunak S.; Garnett, Aaron T.; Amacher, Sharon L.; Conboy, John G.

    2012-01-01

    Rbfox RNA binding proteins are implicated as regulators of phylogenetically-conserved alternative splicing events important for muscle function. To investigate the function of rbfox genes, we used morpholino-mediated knockdown of muscle-expressed rbfox1l and rbfox2 in zebrafish embryos. Single and double morphant embryos exhibited changes in splicing of overlapping sets of bioinformatically-predicted rbfox target exons, many of which exhibit a muscle-enriched splicing pattern that is conserved in vertebrates. Thus, conservation of intronic Rbfox binding motifs is a good predictor of Rbfox-regulated alternative splicing. Morphology and development of single morphant embryos was strikingly normal; however, muscle development in double morphants was severely disrupted. Defects in cardiac muscle were marked by reduced heart rate and in skeletal muscle by complete paralysis. The predominance of wavy myofibers and abnormal thick and thin filaments in skeletal muscle revealed that myofibril assembly is defective and disorganized in double morphants. Ultra-structural analysis revealed that although sarcomeres with electron dense M- and Z-bands are present in muscle fibers of rbfox1l/rbox2 morphants, they are substantially reduced in number and alignment. Importantly, splicing changes and morphological defects were rescued by expression of morpholino-resistant rbfox cDNA. Additionally, a target-blocking MO complementary to a single UGCAUG motif adjacent to an rbfox target exon of fxr1 inhibited inclusion in a similar manner to rbfox knockdown, providing evidence that Rbfox regulates the splicing of target exons via direct binding to intronic regulatory motifs. We conclude that Rbfox proteins regulate an alternative splicing program essential for vertebrate heart and skeletal muscle function. PMID:21925157

  14. Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions.

    Science.gov (United States)

    Gallagher, Thomas L; Arribere, Joshua A; Geurts, Paul A; Exner, Cameron R T; McDonald, Kent L; Dill, Kariena K; Marr, Henry L; Adkar, Shaunak S; Garnett, Aaron T; Amacher, Sharon L; Conboy, John G

    2011-11-15

    Rbfox RNA binding proteins are implicated as regulators of phylogenetically-conserved alternative splicing events important for muscle function. To investigate the function of rbfox genes, we used morpholino-mediated knockdown of muscle-expressed rbfox1l and rbfox2 in zebrafish embryos. Single and double morphant embryos exhibited changes in splicing of overlapping sets of bioinformatically-predicted rbfox target exons, many of which exhibit a muscle-enriched splicing pattern that is conserved in vertebrates. Thus, conservation of intronic Rbfox binding motifs is a good predictor of Rbfox-regulated alternative splicing. Morphology and development of single morphant embryos were strikingly normal; however, muscle development in double morphants was severely disrupted. Defects in cardiac muscle were marked by reduced heart rate and in skeletal muscle by complete paralysis. The predominance of wavy myofibers and abnormal thick and thin filaments in skeletal muscle revealed that myofibril assembly is defective and disorganized in double morphants. Ultra-structural analysis revealed that although sarcomeres with electron dense M- and Z-bands are present in muscle fibers of rbfox1l/rbox2 morphants, they are substantially reduced in number and alignment. Importantly, splicing changes and morphological defects were rescued by expression of morpholino-resistant rbfox cDNA. Additionally, a target-blocking MO complementary to a single UGCAUG motif adjacent to an rbfox target exon of fxr1 inhibited inclusion in a similar manner to rbfox knockdown, providing evidence that Rbfox regulates the splicing of target exons via direct binding to intronic regulatory motifs. We conclude that Rbfox proteins regulate an alternative splicing program essential for vertebrate heart and skeletal muscle functions. Published by Elsevier Inc.

  15. Adenosine A1 receptors (A1Rs) play a critical role in osteoclast formation and function

    OpenAIRE

    Kara, Firas M.; Chitu, Violeta; Sloane, Jennifer; Axelrod, Matthew; Fredholm, Bertil B.; Stanley, E. Richard; Cronstein, Bruce N.

    2010-01-01

    Adenosine regulates a wide variety of physiological processes via interaction with one or more G-protein-coupled receptors (A1R, A2AR, A2BR, and A3R). Because A1R occupancy promotes fusion of human monocytes to form giant cells in vitro, we determined whether A1R occupancy similarly promotes osteoclast function and formation. Bone marrow cells (BMCs) were harvested from C57Bl/6 female mice or A1R-knockout mice and their wild-type (WT) littermates and differentiated into osteoclasts in the pre...

  16. A critical cluster analysis of 44 indicators of author-level performance

    DEFF Research Database (Denmark)

    Wildgaard, Lorna Elizabeth

    2016-01-01

    -four indicators of individual researcher performance were computed using the data. The clustering solution was supported by continued reference to the researcher’s curriculum vitae, an effect analysis and a risk analysis. Disciplinary appropriate indicators were identified and used to divide the researchers......This paper explores a 7-stage cluster methodology as a process to identify appropriate indicators for evaluation of individual researchers at a disciplinary and seniority level. Publication and citation data for 741 researchers from 4 disciplines was collected in Web of Science. Forty...... of statistics in research evaluation. The strength of the 7-stage cluster methodology is that it makes clear that in the evaluation of individual researchers, statistics cannot stand alone. The methodology is reliant on contextual information to verify the bibliometric values and cluster solution...

  17. Performance practice and functions of local wine and beer parlor ...

    African Journals Online (AJOL)

    Since the phenomenon of music is ubiquitous and indispensable among the Yoruba and Africans in general, beer and wine parlors/shops engages in one form of musical ... The songs also plays some psychological roles and plays functional roles in celebrating drinking and relaxation session after a stressful day work.

  18. Measuring the sustainability of a natural system by using multi-criteria distance function methods: Some critical issues.

    Science.gov (United States)

    Diaz-Balteiro, L; Belavenutti, P; Ezquerro, M; González-Pachón, J; Ribeiro Nobre, S; Romero, C

    2018-05-15

    There is an important body of literature using multi-criteria distance function methods for the aggregation of a battery of sustainability indicators in order to obtain a composite index. This index is considered to be a proxy of the sustainability goodness of a natural system. Although this approach has been profusely used in the literature, it is not exempt from difficulties and potential pitfalls. Thus, in this paper, a significant number of critical issues have been identified showing different procedures capable of avoiding, or at least of mitigating, the inherent potential pitfalls associated with each one. The recommendations made in the paper could increase the theoretical soundness of the multi-criteria distance function methods when this type of approach is applied in the sustainability field, thus increasing the accuracy and realism of the sustainability measurements obtained. Copyright © 2018 Elsevier Ltd. All rights reserved.

  19. DOCK8 is critical for the survival and function of NKT cells.

    Science.gov (United States)

    Crawford, Greg; Enders, Anselm; Gileadi, Uzi; Stankovic, Sanda; Zhang, Qian; Lambe, Teresa; Crockford, Tanya L; Lockstone, Helen E; Freeman, Alexandra; Arkwright, Peter D; Smart, Joanne M; Ma, Cindy S; Tangye, Stuart G; Goodnow, Christopher C; Cerundolo, Vincenzo; Godfrey, Dale I; Su, Helen C; Randall, Katrina L; Cornall, Richard J

    2013-09-19

    Patients with the dedicator of cytokinesis 8 (DOCK8) immunodeficiency syndrome suffer from recurrent viral and bacterial infections, hyper-immunoglobulin E levels, eczema, and greater susceptibility to cancer. Because natural killer T (NKT) cells have been implicated in these diseases, we asked if these cells were affected by DOCK8 deficiency. Using a mouse model, we found that DOCK8 deficiency resulted in impaired NKT cell development, principally affecting the formation and survival of long-lived, differentiated NKT cells. In the thymus, DOCK8-deficient mice lack a terminally differentiated subset of NK1.1(+) NKT cells expressing the integrin CD103, whereas in the liver, DOCK8-deficient NKT cells express reduced levels of the prosurvival factor B-cell lymphoma 2 and the integrin lymphocyte function-associated antigen 1. Although the initial NKT cell response to antigen is intact in the absence of DOCK8, their ongoing proliferative and cytokine responses are impaired. Importantly, a similar defect in NKT cell numbers was detected in DOCK8-deficient humans, highlighting the relevance of the mouse model. In conclusion, our data demonstrate that DOCK8 is required for the development and survival of mature NKT cells, consistent with the idea that DOCK8 mediates survival signals within a specialized niche. Accordingly, impaired NKT cell numbers and function are likely to contribute to the susceptibility of DOCK8-deficient patients to recurrent infections and malignant disease.

  20. DOCK8 is critical for the survival and function of NKT cells

    Science.gov (United States)

    Crawford, Greg; Enders, Anselm; Gileadi, Uzi; Stankovic, Sanda; Zhang, Qian; Lambe, Teresa; Crockford, Tanya L.; Lockstone, Helen E.; Freeman, Alexandra; Arkwright, Peter D.; Smart, Joanne M.; Ma, Cindy S.; Tangye, Stuart G.; Goodnow, Christopher C.; Cerundolo, Vincenzo; Godfrey, Dale I.; Su, Helen C.; Randall, Katrina L.

    2013-01-01

    Patients with the dedicator of cytokinesis 8 (DOCK8) immunodeficiency syndrome suffer from recurrent viral and bacterial infections, hyper–immunoglobulin E levels, eczema, and greater susceptibility to cancer. Because natural killer T (NKT) cells have been implicated in these diseases, we asked if these cells were affected by DOCK8 deficiency. Using a mouse model, we found that DOCK8 deficiency resulted in impaired NKT cell development, principally affecting the formation and survival of long-lived, differentiated NKT cells. In the thymus, DOCK8-deficient mice lack a terminally differentiated subset of NK1.1+ NKT cells expressing the integrin CD103, whereas in the liver, DOCK8-deficient NKT cells express reduced levels of the prosurvival factor B-cell lymphoma 2 and the integrin lymphocyte function-associated antigen 1. Although the initial NKT cell response to antigen is intact in the absence of DOCK8, their ongoing proliferative and cytokine responses are impaired. Importantly, a similar defect in NKT cell numbers was detected in DOCK8-deficient humans, highlighting the relevance of the mouse model. In conclusion, our data demonstrate that DOCK8 is required for the development and survival of mature NKT cells, consistent with the idea that DOCK8 mediates survival signals within a specialized niche. Accordingly, impaired NKT cell numbers and function are likely to contribute to the susceptibility of DOCK8-deficient patients to recurrent infections and malignant disease. PMID:23929855

  1. Trichostatin A, a critical factor in maintaining the functional differentiation of primary cultured rat hepatocytes

    International Nuclear Information System (INIS)

    Henkens, Tom; Papeleu, Peggy; Elaut, Greetje; Vinken, Mathieu; Rogiers, Vera; Vanhaecke, Tamara

    2007-01-01

    Histone deacetylase inhibitors (HDI) have been shown to increase differentiation-related gene expression in several tumor-derived cell lines by hyperacetylating core histones. Effects of HDI on primary cultured cells, however, have hardly been investigated. In the present study, the ability of trichostatin A (TSA), a prototype hydroxamate HDI, to counteract the loss of liver-specific functions in primary rat hepatocyte cultures has been investigated. Upon exposure to TSA, it was found that the cell viability of the cultured hepatocytes and their albumin secretion as a function of culture time were increased. TSA-treated hepatocytes also better maintained cytochrome P450 (CYP)-mediated phase I biotransformation capacity, whereas the activity of phase II glutathione S-transferases (GST) was not affected. Western blot and qRT-PCR analysis of CYP1A1, CYP2B1 and CYP3A11 protein and mRNA levels, respectively, further revealed that TSA acts at the transcriptional level. In addition, protein expression levels of the liver-enriched transcription factors (LETFs) hepatic nuclear factor 4 alpha (HNF4α) and CCAAT/enhancer binding protein alpha (C/EBPα) were accordingly increased by TSA throughout culture time. In conclusion, these findings indicate that TSA plays a major role in the preservation of the differentiated hepatic phenotype in culture. It is suggested that the effects of TSA on CYP gene expression are mediated via controlling the expression of LETFs

  2. High lumenal chloride in the lysosome is critical for lysosome function

    Science.gov (United States)

    Chakraborty, Kasturi; Leung, KaHo; Krishnan, Yamuna

    2017-01-01

    Lysosomes are organelles responsible for the breakdown and recycling of cellular machinery. Dysfunctional lysosomes give rise to lysosomal storage disorders as well as common neurodegenerative diseases. Here, we use a DNA-based, fluorescent chloride reporter to measure lysosomal chloride in Caenorhabditis elegans as well as murine and human cell culture models of lysosomal diseases. We find that the lysosome is highly enriched in chloride, and that chloride reduction correlates directly with a loss in the degradative function of the lysosome. In nematodes and mammalian cell culture models of diverse lysosomal disorders, where previously only lysosomal pH dysregulation has been described, massive reduction of lumenal chloride is observed that is ~103 fold greater than the accompanying pH change. Reducing chloride within the lysosome impacts Ca2+ release from the lysosome and impedes the activity of specific lysosomal enzymes indicating a broader role for chloride in lysosomal function. DOI: http://dx.doi.org/10.7554/eLife.28862.001 PMID:28742019

  3. The adaptor molecule RIAM integrates signaling events critical for integrin-mediated control of immune function and cancer progression.

    Science.gov (United States)

    Patsoukis, Nikolaos; Bardhan, Kankana; Weaver, Jessica D; Sari, Duygu; Torres-Gomez, Alvaro; Li, Lequn; Strauss, Laura; Lafuente, Esther M; Boussiotis, Vassiliki A

    2017-08-22

    Lymphocyte activation requires adhesion to antigen-presenting cells. This is a critical event linking innate and adaptive immunity. Lymphocyte adhesion is accomplished through LFA-1, which must be activated by a process referred to as inside-out integrin signaling. Among the few signaling molecules that have been implicated in inside-out integrin activation in hematopoietic cells are the small guanosine triphosphatase (GTPase) Rap1 and its downstream effector Rap1-interacting molecule (RIAM), a multidomain protein that defined the Mig10-RIAM-lamellipodin (MRL) class of adaptor molecules. Through its various domains, RIAM is a critical node of signal integration for activation of T cells, recruits monomeric and polymerized actin to drive actin remodeling and cytoskeletal reorganization, and promotes inside-out integrin signaling in T cells. As a regulator of inside-out integrin activation, RIAM affects multiple functions of innate and adaptive immunity. The effects of RIAM on cytoskeletal reorganization and integrin activation have implications in cell migration and trafficking of cancer cells. We provide an overview of the structure and interactions of RIAM, and we discuss the implications of RIAM functions in innate and adaptive immunity and cancer. Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

  4. A critical spare part inventory control based on hazard function approach: A case study in a garment company

    Science.gov (United States)

    Melinda, Intan Dewi; Jauhari, Wakhid Ahmad

    2018-02-01

    Spare part procurement is a complex issue and requires an accurate analysis. Stock outs of spare part can leads a great impact on production. Therefore, it is necessary to design the inventory control of spare parts that guarantee the availability of spare parts needed for supporting the maintenance activity. This paper studies the inventory policy for sewing machine spare part using hazard function to approximate the demand. Hazard function is the indicator of the effect of ageing on the reliability of the system. It quantifies the risk of failure as the age of the system increases. We use a continuous review policy based on Hadley Within Approach to calculate the optimum inventory level for critical spare parts. There are four spare parts categorized as critical spare parts, which are needle plate, feed dog, rotary and binder attachment. The optimal ordering quantity for needle plate, feed, rotary and binder attachment are 5 units, 17 units, 5 units, and 9 units, respectively and the reorder point are 2 units, 1 unit, 2 units and 1 unit, respectively. Finally, the service level achieved by the proposed policy is in a range of 95.91%-97.93%, which indicates that the inventory level of spare parts can be used to support the required parts in the maintenance activity.

  5. Effects of Different Forms of Concept-Map Representation on Nursing Students’ Critical Thinking Performances

    Directory of Open Access Journals (Sweden)

    Chin-Yuan Lai

    2015-06-01

    Full Text Available Representation is important for problem solving. This study examined the effects of different forms of concept maps on nursing students’ performances of conceptualizing psychiatric patients’ problems. A quasi-experimental research design was adopted to investigate the effects. The participants were two classes of fourth-year students who were enrolled in a psychiatric nursing course in a nursing college. One class with 48 students served as the experimental group, and used web-based concepts map to represent patients’ problem. The other class with 50 students served as the control group, and used the traditional hierarchical concept mapping method. The results indicated that the concept maps drawn by the experimental group showed more nursing problem, supporting evidence, and relationships between nursing problems than those drawn by the control group. The web-based concept maps helped expand students’ thinking and promoted their causality reasoning. Different concept-map representation tools affected the process of students’ problem solving. The experimental learning activities promoted students’ understanding of concepts and ways of psychiatric patients’ care taking. To understand the effects of other types of concept maps, future research may guide students in using different forms of concept maps throughout the stages of nursing process.

  6. Analytical performances of food microbiology laboratories - critical analysis of 7 years of proficiency testing results.

    Science.gov (United States)

    Abdel Massih, M; Planchon, V; Polet, M; Dierick, K; Mahillon, J

    2016-02-01

    Based on the results of 19 food microbiology proficiency testing (PT) schemes, this study aimed to assess the laboratory performances, to highlight the main sources of unsatisfactory analytical results and to suggest areas of improvement. The 2009-2015 results of REQUASUD and IPH PT, involving a total of 48 laboratories, were analysed. On average, the laboratories failed to detect or enumerate foodborne pathogens in 3·0% of the tests. Thanks to a close collaboration with the PT participants, the causes of outliers could be identified in 74% of the cases. The main causes of erroneous PT results were either pre-analytical (handling of the samples, timing of analysis), analytical (unsuitable methods, confusion of samples, errors in colony counting or confirmation) or postanalytical mistakes (calculation and encoding of results). PT schemes are a privileged observation post to highlight analytical problems, which would otherwise remain unnoticed. In this perspective, this comprehensive study of PT results provides insight into the sources of systematic errors encountered during the analyses. This study draws the attention of the laboratories to the main causes of analytical errors and suggests practical solutions to avoid them, in an educational purpose. The observations support the hypothesis that regular participation to PT, when followed by feed-back and appropriate corrective actions, can play a key role in quality improvement and provide more confidence in the laboratory testing results. © 2015 The Society for Applied Microbiology.

  7. Critical assessment of three high performance liquid chromatography analytical methods for food carotenoid quantification.

    Science.gov (United States)

    Dias, M Graça; Oliveira, Luísa; Camões, M Filomena G F C; Nunes, Baltazar; Versloot, Pieter; Hulshof, Paul J M

    2010-05-21

    Three sets of extraction/saponification/HPLC conditions for food carotenoid quantification were technically and economically compared. Samples were analysed for carotenoids alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein, lycopene, and zeaxanthin. All methods demonstrated good performance in the analysis of a composite food standard reference material for the analytes they are applicable to. Methods using two serial connected C(18) columns and a mobile phase based on acetonitrile, achieved a better carotenoid separation than the method using a mobile phase based on methanol and one C(18)-column. Carotenoids from leafy green vegetable matrices appeared to be better extracted with a mixture of methanol and tetrahydrofuran than with tetrahydrofuran alone. Costs of carotenoid determination in foods were lower for the method with mobile phase based on methanol. However for some food matrices and in the case of E-Z isomer separations, this was not technically satisfactory. Food extraction with methanol and tetrahydrofuran with direct evaporation of these solvents, and saponification (when needed) using pyrogallol as antioxidant, combined with a HPLC system using a slight gradient mobile phase based on acetonitrile and a stationary phase composed by two serial connected C(18) columns was the most technically and economically favourable method. 2010. Published by Elsevier B.V.

  8. Performance of Hybrid Reinforced Concrete Beam Column Joint: A Critical Review

    Directory of Open Access Journals (Sweden)

    Md Rashedul Kabir

    2016-04-01

    Full Text Available Large residual strain in reinforced concrete structures after a seismic event is a major concern for structural safety and serviceability. Alternative reinforcement materials like fiber-reinforced polymer (FRP have been widely used to mitigate corrosion problems associated with steel. Low modulus of elasticity and brittle behavior compared to steel has made the use of FRP unsuitable in seismic resistant strictures. A combination of steel-FRP reinforcement configuration can address the problem of corrosion. Therefore, introducing a material that shows strong post elastic behavior without any decay due to corrosion is in demand. Shape memory alloy (SMA, a novel material, is highly corrosion resistive and shows super elastic property. Coupling SMA with FRP or steel in the plastic hinge region allows the structure to undergo large deformations, but regains its original shape upon unloading. In this study, the performance characteristics of four previously tested beam-column joints reinforced with different configurations (steel, SMA/steel, glass fiber reinforced polymer (GFRP and SMA/FRP are compared to assess their capacity to endure extreme loading. Experimental results are scrutinized to compare the behavior of these specimens in terms of load-story drift and energy dissipation capacity. SMA/FRP and SMA/Steel couples have been found to be an acceptable approach to reduce residual deformation in beam-column joints with adequate energy dissipation capacity. However, SMA/FRP is superior to SMA/Steel concerning to the corrosion issue in steel.

  9. Critical transport issues for improving the performance of aqueous redox flow batteries

    Science.gov (United States)

    Zhou, X. L.; Zhao, T. S.; An, L.; Zeng, Y. K.; Wei, L.

    2017-01-01

    As the fraction of electricity generated from intermittent renewable sources (such as solar and wind) grows, developing reliable energy storage technologies to store electrical energy in large scale is of increasing importance. Redox flow batteries are now enjoying a renaissance and regarded as a leading technology in providing a well-balanced solution for current daunting challenges. In this article, state-of-the-art studies of the complex multicomponent transport phenomena in aqueous redox flow batteries, with a special emphasis on all-vanadium redox flow batteries, are reviewed and summarized. Rather than elaborating on the details of previous experimental and numerical investigations, this article highlights: i) the key transport issues in each battery's component that need to be tackled so that the rate capability and cycling stability of flow batteries can be significantly improved, ii) the basic mechanisms that control the active species/ion/electron transport behaviors in each battery's component, and iii) the key experimental and numerical findings regarding the correlations between the multicomponent transport processes and battery performance.

  10. Tumor microenvironment and metabolic synergy in breast cancers: critical importance of mitochondrial fuels and function.

    Science.gov (United States)

    Martinez-Outschoorn, Ubaldo; Sotgia, Federica; Lisanti, Michael P

    2014-04-01

    Metabolic synergy or metabolic coupling between glycolytic stromal cells (Warburg effect) and oxidative cancer cells occurs in human breast cancers and promotes tumor growth. The Warburg effect or aerobic glycolysis is the catabolism of glucose to lactate to obtain adenosine triphosphate (ATP). This review summarizes the main findings on this stromal metabolic phenotype, and the associated signaling pathways, as well as the critical role of oxidative stress and autophagy, all of which promote carcinoma cell mitochondrial metabolism and tumor growth. Loss of Caveolin 1 (Cav-1) and the upregulation of monocarboxylate transporter 4 (MCT4) in stromal cells are novel markers of the Warburg effect and metabolic synergy between stromal and carcinoma cells. MCT4 and Cav-1 are also breast cancer prognostic biomarkers. Reactive oxygen species (ROS) are key mediators of the stromal Warburg effect. High ROS also favors cancer cell mitochondrial metabolism and tumorigenesis, and anti-oxidants can reverse this altered stromal and carcinoma metabolism. A pseudo-hypoxic state with glycolysis and low mitochondrial metabolism in the absence of hypoxia is a common feature in breast cancer. High ROS induces loss of Cav-1 in stromal cells and is sufficient to generate a pseudo-hypoxic state. Loss of Cav-1 in the stroma drives glycolysis and lactate extrusion via HIF-1α stabilization and the upregulation of MCT4. Stromal cells with loss of Cav-1 and/or high expression of MCT4 also show a catabolic phenotype, with enhanced macroautophagy. This catabolic state in stromal cells is driven by hypoxia-inducible factor (HIF)-1α, nuclear factor κB (NFκB), and JNK activation and high ROS generation. A feed-forward loop in stromal cells regulates pseudo-hypoxia and metabolic synergy, with Cav-1, MCT4, HIF-1α, NFκB, and ROS as its key elements. Metabolic synergy also may occur between cancer cells and cells in distant organs from the tumor. Cancer cachexia, which is due to severe organismal

  11. Separation of photo-induced radical pair in cryptochrome to a functionally critical distance

    DEFF Research Database (Denmark)

    Solov'yov, Ilia; Domratcheva, Tatiana; Schulten, Klaus

    2014-01-01

    Cryptochrome is a blue light receptor that acts as a sensor for the geomagnetic field and assists many animals in long-range navigation. The magnetoreceptor function arises from light-induced formation of a radical pair through electron transfer between a flavin cofactor (FAD) and a triad...... of tryptophan residues. Here, this electron transfer is investigated by quantum chemical and classical molecular dynamics calculations. The results reveal how sequential electron transfer, assisted by rearrangement of polar side groups in the cryptochrome interior, can yield a FAD-Trp radical pair state...... step can overcome in speed both recombination (electron back-transfer) and proton transfer involving the radical pair reached after primary electron transfer....

  12. Critical success factors influencing the performance of development projects: An empirical study of Constituency Development Fund projects in Kenya

    Directory of Open Access Journals (Sweden)

    Debadyuti Das

    2017-12-01

    Full Text Available The present work attempts to identify critical success factors (CSFs influencing the performance of development projects based on their key performance indicators (KPIs. It has considered the case of Constituency Development Fund (CDF projects constructed between 2003 and 2011 in Kenya and secured the perceptions of 175 respondents comprising clients, consultants and contractors involved in the implementation of CDF projects on 30 success variables. Findings reveal that individual items constituting these six factors represent six CSFs namely project-related, client-related, consultant-related, contractor-related, supply chain-related, and external environment-related factor. The findings are also relevant to development projects undertaken in other developing countries.

  13. From centriole biogenesis to cellular function: centrioles are essential for cell division at critical developmental stages.

    Science.gov (United States)

    Rodrigues-Martins, Ana; Riparbelli, Maria; Callaini, Giuliano; Glover, David M; Bettencourt-Dias, Monica

    2008-01-01

    Centrioles are essential for the formation of cilia, flagella and centrosome organization. Abnormalities in centrosome structure and number in many cancers can be associated with aberrant cell division and genomic instability.(1,2) Canonical centriole duplication occurs in coordination with the cell division cycle, such that a single new "daughter" centriole arises next to each "mother" centriole. If destroyed, or eliminated during development, centrioles can form de novo.(3-5) Here we discuss our recent data demonstrating a molecular pathway that operates in both de novo and canonical centriole biogenesis involving SAK/PLK4, SAS-6 and SAS-4.(6) We showed that centriole biogenesis is a self-assembly process locally triggered by high SAK/PLK4 activity that may or not be associated with an existing centriole. SAS-6 acts downstream of SAK/PLK4 to organize nine precentriolar units, which we call here enatosomes, fitting together laterally and longitudinally, specifying a tube-like centriole precursor.(7,8) The identification of mutants impaired in centriole biogenesis has permitted the study of the physiological consequences of their absence in the whole organism. In Drosophila, centrioles are not necessary for somatic cell divisions.(9,10) However, we show here that mitotic abnormalities arise in syncytial SAK/PLK4-derived mutant embryos resulting in lethality. Moreover male meiosis fails in both SAK/PLK4 and DSAS-4 mutant spermatids that have no centrioles. These results show diversity in the need for centrioles in cell division. This suggests that tissue specific constraints selected for different contributions of centrosome-independent and dependent mechanisms in spindle function. This heterogeneity should be taken into account both in reaching an understanding of spindle function and when designing drugs that target cell division.

  14. Importance and performance evaluation tools for small and medium companies: critical analysis of national versus international literature

    Directory of Open Access Journals (Sweden)

    Sandro César Bortoluzzi

    2015-12-01

    Full Text Available The research aims to map the importance and performance evaluation tools for small and medium companies. This descriptive and qualitative study analyzed 33 national articles and 21 international ones. Regarding the importance of performance evaluation for small and medium companies, the literature highlights: (i it increases the success of the network; (ii it is useful for management; (iii it strengthens competitiveness; (iv it consolidates cooperation; and, (v it increases trust among partners. Comparing the national versus international literature on the importance of performance evaluation for small and medium companies, it can be noticed similar and complementary aspects, that is, there is not disagreement between the authors. The authors use tools consolidated in the literature, such as Balanced Scorecard; Benchmarking; Performance Prism and tools proposed specifically to evaluate small and medium networks. The main dimensions evaluated are: (i exchange of information; (ii value management in networks; (Iii level of network maturity; (iv benefits of collaboration; (v social capital; (vi collective efficiency; (vii network life cycle; (viii efficiency and inefficiency of the networks; and, (ix existence and intensity of the relationship between partners. The critical analysis regarding the performance evaluation concept adopted in the present study shows that the tools proposed or implemented to evaluate small and medium business networks have gaps in the process to identify criteria, measure ordinal and cardinally, integrate and generate actions of improvement.

  15. The FPGA realization of the general cellular automata based cryptographic hash functions: Performance and effectiveness

    Directory of Open Access Journals (Sweden)

    P. G. Klyucharev

    2014-01-01

    Full Text Available In the paper the author considers hardware implementation of the GRACE-H family general cellular automata based cryptographic hash functions. VHDL is used as a language and Altera FPGA as a platform for hardware implementation. Performance and effectiveness of the FPGA implementations of GRACE-H hash functions were compared with Keccak (SHA-3, SHA-256, BLAKE, Groestl, JH, Skein hash functions. According to the performed tests, performance of the hardware implementation of GRACE-H family hash functions significantly (up to 12 times exceeded performance of the hardware implementation of previously known hash functions, and effectiveness of that hardware implementation was also better (up to 4 times.

  16. Functional handwriting performance in school-age children with fetal alcohol spectrum disorders.

    Science.gov (United States)

    Duval-White, Cherie J; Jirikowic, Tracy; Rios, Dianne; Deitz, Jean; Olson, Heather Carmichael

    2013-01-01

    Handwriting is a critical skill for school success. Children with fetal alcohol spectrum disorders (FASD) often present with fine motor and visual-motor impairments that can affect handwriting performance, yet handwriting skills have not been systematically investigated in this clinical group. This study aimed to comprehensively describe handwriting skills in 20 school-age children with FASD. Children were tested with the Process Assessment of the Learner, 2nd Edition (PAL-II), and the Visuomotor Precision subtest of NEPSY, a developmental neuropsychological assessment. Participants performed below average on PAL-II measures of handwriting legibility and speed and on NEPSY visual-motor precision tasks. In contrast, PAL-II measures of sensorimotor skills were broadly within the average range. Results provide evidence of functional handwriting challenges for children with FASD and suggest diminished visual-motor skills and increased difficulty as task complexity increases. Future research is needed to further describe the prevalence and nature of handwriting challenges in this population. Copyright © 2013 by the American Occupational Therapy Association, Inc.

  17. Probabilistic Criticality Consequence Evaluation

    International Nuclear Information System (INIS)

    P. Gottlieb; J.W. Davis; J.R. Massari

    1996-01-01

    This analysis is prepared by the Mined Geologic Disposal System (MGDS) Waste Package Development (WPD) department with the objective of providing a comprehensive, conservative estimate of the consequences of the criticality which could possibly occur as the result of commercial spent nuclear fuel emplaced in the underground repository at Yucca Mountain. The consequences of criticality are measured principally in terms of the resulting changes in radionuclide inventory as a function of the power level and duration of the criticality. The purpose of this analysis is to extend the prior estimates of increased radionuclide inventory (Refs. 5.52 and 5.54), for both internal and external criticality. This analysis, and similar estimates and refinements to be completed before the end of fiscal year 1997, will be provided as input to Total System Performance Assessment-Viability Assessment (TSPA-VA) to demonstrate compliance with the repository performance objectives

  18. Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions.

    Science.gov (United States)

    Guitart, Amelie V; Panagopoulou, Theano I; Villacreces, Arnaud; Vukovic, Milica; Sepulveda, Catarina; Allen, Lewis; Carter, Roderick N; van de Lagemaat, Louie N; Morgan, Marcos; Giles, Peter; Sas, Zuzanna; Gonzalez, Marta Vila; Lawson, Hannah; Paris, Jasmin; Edwards-Hicks, Joy; Schaak, Katrin; Subramani, Chithra; Gezer, Deniz; Armesilla-Diaz, Alejandro; Wills, Jimi; Easterbrook, Aaron; Coman, David; So, Chi Wai Eric; O'Carroll, Donal; Vernimmen, Douglas; Rodrigues, Neil P; Pollard, Patrick J; Morton, Nicholas M; Finch, Andrew; Kranc, Kamil R

    2017-03-06

    Strict regulation of stem cell metabolism is essential for tissue functions and tumor suppression. In this study, we investigated the role of fumarate hydratase (Fh1), a key component of the mitochondrial tricarboxylic acid (TCA) cycle and cytosolic fumarate metabolism, in normal and leukemic hematopoiesis. Hematopoiesis-specific Fh1 deletion (resulting in endogenous fumarate accumulation and a genetic TCA cycle block reflected by decreased maximal mitochondrial respiration) caused lethal fetal liver hematopoietic defects and hematopoietic stem cell (HSC) failure. Reexpression of extramitochondrial Fh1 (which normalized fumarate levels but not maximal mitochondrial respiration) rescued these phenotypes, indicating the causal role of cellular fumarate accumulation. However, HSCs lacking mitochondrial Fh1 (which had normal fumarate levels but defective maximal mitochondrial respiration) failed to self-renew and displayed lymphoid differentiation defects. In contrast, leukemia-initiating cells lacking mitochondrial Fh1 efficiently propagated Meis1 / Hoxa9 -driven leukemia. Thus, we identify novel roles for fumarate metabolism in HSC maintenance and hematopoietic differentiation and reveal a differential requirement for mitochondrial Fh1 in normal hematopoiesis and leukemia propagation. © 2017 Guitart et al.

  19. JOYO MK-III performance test. Criticality test, excess reactivity measurement and burn-up coefficient measurement

    International Nuclear Information System (INIS)

    Maeda, Shigetaka; Sekine, Takashi; Kitano, Akihiro; Nagasaki, Hideaki

    2005-03-01

    The MK-III performance test began in June 2003 to fully characterize the upgraded core and heat transfer system of the experimental fast reactor JOYO. This paper describes the results of the approach to criticality, the excess reactivity evaluation and the burn-up coefficient measurement. In the approach to criticality test, the MK-III core achieved initial criticality at the control rod bank position of 412.8 mm on 14:03 July 2nd, 2003. Because the replacement of the outer two rows of reflector subassemblies with shielding subassemblies reduced the source range monitor signals by a factor of 3 at the same reactor power compared with those in the MK-II core, we measured the change of the monitor's response and determined the count rate 2x10 4 cps.' as an appropriate value judging the zero power criticality. In the excess reactivity evaluation, the zero power excess reactivity at 250degC was 2.99±0.10%Δk/kk' based on the measured critical rod bank position and the measured control rod worths. The predicted value by the JOYO core management code system HESTIA was 3.13±0.16%Δk/kk', showing good agreement with the measured value. The measured excess reactivity was within the safety requirement limit. In the burn-up coefficient measurement, the excess reactivity change versus the reactor burn-up was evaluated. The measurement method adopted was to measure the control rod positions during the rated power operation. A value of -2.12x10 -4 Δk/kk'/MWd was obtained as a measured burn-up coefficient. The value calculated by HESTIA was -2.12x10 -4 Δk/kk'/MWd, and it agreed well with the measured value. All technical safety requirements for MK-III core were satisfied and the calculation accuracy of the core management code system HESTIA was confirmed. (author)

  20. Influence function method for fast estimation of BWR core performance

    International Nuclear Information System (INIS)

    Rahnema, F.; Martin, C.L.; Parkos, G.R.; Williams, R.D.

    1993-01-01

    The model, which is based on the influence function method, provides rapid estimate of important quantities such as margins to fuel operating limits, the effective multiplication factor, nodal power and void and bundle flow distributions as well as the traversing in-core probe (TIP) and local power range monitor (LPRM) readings. The fast model has been incorporated into GE's three-dimensional core monitoring system (3D Monicore). In addition to its predicative capability, the model adapts to LPRM readings in the monitoring mode. Comparisons have shown that the agreement between the results of the fast method and those of the standard 3D Monicore is within a few percent. (orig.)

  1. Functionalizing aluminum substrata by quaternary ammonium for antifouling performances

    Science.gov (United States)

    He, Xiaoyan; Suo, Xinkun; Bai, Xiuqin; Yuan, Chengqing; Li, Hua

    2018-05-01

    Due to the great loss induced by biofouling, developing new strategies for combating biofouling has attracted extensive attention. Quaternary ammonium salts are potent cationic antimicrobials used in consumer products and their use for surface immobilization could create a contact-active antimicrobial layer. Here we report the facile preparation of a contact-active antifouling coating by tethering polyethyleneimine (PEI) onto flat/nanostructured aluminum surface by hydrogen bonding between PEI and AlOOH. Quaternized PEI (QPEI) is obtained through quaternization reactions. Biofouling testing suggests excellent antifouling performances of the samples by declining the adhesion of 95% Phaeodactylum tricornutum and 98% of Chlorella pyrenoidosa. The antifouling properties of PEI/QPEI are attributed predominately to their hydrophilic and antimicrobial nature. The technical route of PEI/QPEI surface grafting shows great potential for modifying marine infrastructures for enhanced antifouling performances.

  2. CFD analysis of PAR performance as function of inlet design

    Energy Technology Data Exchange (ETDEWEB)

    Park, Kweonha, E-mail: khpark@kmou.ac.kr [Division of Mechanical and Energy systems Engineering, Korea Maritime University, Dongsam-dong, Yeongdo-gu, Busan 606-791 (Korea, Republic of); Khor, Chong Lee, E-mail: itachi_829@hotmail.com [Department of Mechanical Engineering, Korea Maritime University (Korea, Republic of)

    2016-01-15

    Highlights: • The new concept of PAR (passive autocatalytic recombiner) was proposed and analyzed. • Guidance wall was added at the bottom of PAR to enhance the flow rate through the catalyst. • The new concept of PAR was proved to have a better hydrogen removal performance. - Abstract: Passive autocatalytic recombiner (PAR) is very useful hydrogen mitigation measurement. It is widely implemented in the current and advanced light water reactors (ALWRs). The design of the PARs should be optimized for the specific use under severe accident scenarios. Several techniques and innovations have been fused into the PAR, as an effort to increase its efficiency of hydrogen mitigation. This study proposes different concepts of PAR, which applied some changes to the honeycomb catalyst PAR made by the Korea Nuclear Technology (KNT) Inc. Two slices of plate are added to the bottom of PAR model, which intended to act as a reflection wall and promote the gas flow into PAR. Hydrogen volume fraction was given 4 vol. % which tested by KNT to investigate the performance of PAR in different direction gas flow conditions to see maximum hydrogen recombination rate. The new concept of PAR was proved to have a better hydrogen removal performance compared to the original honeycomb catalyst PAR.

  3. CFD analysis of PAR performance as function of inlet design

    International Nuclear Information System (INIS)

    Park, Kweonha; Khor, Chong Lee

    2016-01-01

    Highlights: • The new concept of PAR (passive autocatalytic recombiner) was proposed and analyzed. • Guidance wall was added at the bottom of PAR to enhance the flow rate through the catalyst. • The new concept of PAR was proved to have a better hydrogen removal performance. - Abstract: Passive autocatalytic recombiner (PAR) is very useful hydrogen mitigation measurement. It is widely implemented in the current and advanced light water reactors (ALWRs). The design of the PARs should be optimized for the specific use under severe accident scenarios. Several techniques and innovations have been fused into the PAR, as an effort to increase its efficiency of hydrogen mitigation. This study proposes different concepts of PAR, which applied some changes to the honeycomb catalyst PAR made by the Korea Nuclear Technology (KNT) Inc. Two slices of plate are added to the bottom of PAR model, which intended to act as a reflection wall and promote the gas flow into PAR. Hydrogen volume fraction was given 4 vol. % which tested by KNT to investigate the performance of PAR in different direction gas flow conditions to see maximum hydrogen recombination rate. The new concept of PAR was proved to have a better hydrogen removal performance compared to the original honeycomb catalyst PAR.

  4. Evaluation of Thermoelectric Performance and Durability of Functionalized Skutterudite Legs

    Science.gov (United States)

    Skomedal, Gunstein; Kristiansen, Nils R.; Sottong, Reinhard; Middleton, Hugh

    2017-04-01

    Thermoelectric generators are a promising technology for waste heat recovery. As new materials and devices enter a market penetration stage, it is of interest to employ fast and efficient measurement methods to evaluate the long-term stability of thermoelectric materials in combination with metallization and coating (functionalized thermoelectric legs). We have investigated a method for measuring several thermoelectric legs simultaneously. The legs are put under a common temperature gradient, and the electrical characteristics of each leg are measured individually during thermal cycling. Using this method, one can test different types of metallization and coating applied to skutterudite thermoelectric legs and look at the relative changes over time. Postcharacterization of these initial tests with skutterudite legs using a potential Seebeck microprobe and an electron microscope showed that oxidation and interlayer diffusion are the main reasons for the gradual increase in internal resistance and the decrease in open-circuit voltage. Although we only tested skutterudite material in this work, the method is fully capable of testing all kinds of material, metallization, and coating. It is thus a promising method for studying the relationship between failure modes and mechanisms of functionalized thermoelectric legs.

  5. Methodologies for verification and validation of expert systems as a function of component, criticality and life-cycle phase

    International Nuclear Information System (INIS)

    Miller, L.

    1992-01-01

    The review of verification and validation (V and V) methods presented here is based on results of the initial two tasks of a contract with the US Nuclear Regulatory Commission and the Electric Power Research Institute to Develop and Document Guidelines for Verifying and Validating Expert Systems. The first task was to review the applicability of conventional software techniques to expert systems; the second was to directly survey V and V practices associated with development of expert systems. Subsequent tasks will focus on selecting, synthesizing or developing V and V methods appropriate for the overall system, for specific expert systems components, and for different phases of the life-cycle. In addition, final guidelines will most likely be developed for each of three levels of expert systems: safety-related (systems whose functions directly relate to system safety, so-called safety-critical systems), important-to-safety (systems which support the critical safety functions), and non-safety (systems which are unrelated to safety functions). For the present purposes of categorizing and discussing various types of V and V methods, the authors simplify the life-cycle and consider only two aspects - systems validation phase. The authors identified a number of techniques for the first, combined, phase and two general classes of V and V techniques for the latter phase: static testing techniques, which do not involve execution of the system code, and dynamic testing techniques, which do. In the next two sections the author reviews first the applicability to expert systems of conventional V and V techniques and, second, the techniques expert system developers actually use. In the last section the authors make some general observations

  6. Critical force during tethered swimming for the evaluation of aerobic capacity and prediction of performances in freestyle swimming

    Directory of Open Access Journals (Sweden)

    Marcelo Papoti

    2010-01-01

    Full Text Available The present study investigated the relationship of critical force (Fcrit with lactate threshold (LLNA and the intensity corresponding to VO2max (iVO2max in tethered swimming (TS, and their correlation with maximal performance in 400-m (V400 and 30-min (VT30 freestyle swimming (FS. Seven swimmers were submitted to a TS incremental test for the determination of LLNA and iVO2max. For the determination of Fcrit, the swimmers performed four exercises to exhaustion at intensities (F corresponding to 87%, 104%, 118% and 134% of iVO2max for the calculation of time limits (Tlim. Fcrit corresponded to the linear coefficient of the ratio between F and 1/tlim. The maximal performance in FS corresponded to the mean velocity obtained during maximal exercise of 400-m and 30-min crawl swimming. Fcrit (51.97 ± 4.02 N was significantly lower than iVO2max (60.21 ± 8.73 N but not than LLNA (45.89 ± 8.73. Fcrit was significantly correlated with iVO2max (0.97, LLNA (0.88, V400 (0.85, and VT30 (0.86. These data suggest that Fcrit can be used for the determination of aerobic capacity, prescription of a TS training program, and prediction of performance in FS.

  7. Critical-thinking ability in respiratory care students and its correlation with age, educational background, and performance on national board examinations.

    Science.gov (United States)

    Wettstein, Richard B; Wilkins, Robert L; Gardner, Donna D; Restrepo, Ruben D

    2011-03-01

    Critical thinking is an important characteristic to develop in respiratory care students. We used the short-form Watson-Glaser Critical Thinking Appraisal instrument to measure critical-thinking ability in 55 senior respiratory care students in a baccalaureate respiratory care program. We calculated the Pearson correlation coefficient to assess the relationships between critical-thinking score, age, and student performance on the clinical-simulation component of the national respiratory care boards examination. We used chi-square analysis to assess the association between critical-thinking score and educational background. There was no significant relationship between critical-thinking score and age, or between critical-thinking score and student performance on the clinical-simulation component. There was a significant (P = .04) positive association between a strong science-course background and critical-thinking score, which might be useful in predicting a student's ability to perform in areas where critical thinking is of paramount importance, such as clinical competencies, and to guide candidate-selection for respiratory care programs.

  8. Functionality and performance of the ALFA_CTPIN module

    CERN Document Server

    Iwanski, Wieslaw; Korcyl, Krzysztof; Oechsle, Jan

    2017-01-01

    The ALFA_CTPIN module has been designed in response to increased internal processing time of the Central Trigger Processor (CTP) of the ATLAS experiment which resulted in reducing time left to the ALFA detector to deliver its own triggers to the CTP within specified latency. Accelerated extraction of ALFA triggers from encoded signals and the possibility to perform local triggers processing by this module allowed ALFA to contribute to global triggering of the ATLAS detector. A huge number of implemented scalers and flexibility in defining triggers processing criteria make also from this module a very attractive tool for in-depth analysis of properties of the LHC beam.

  9. A performative and poetical narrative of critical social theory in nursing education: an ending and threshold of social justice.

    Science.gov (United States)

    Lapum, Jennifer; Hamzavi, Neda; Veljkovic, Katarina; Mohamed, Zubaida; Pettinato, Adriana; Silver, Sarabeth; Taylor, Elizabeth

    2012-01-01

    In this article, a poetical and performative narrative is shared to examine how the use of stories to critically self-reflect on oppression facilitates an understanding of critical social theory in nursing education and impacts social justice. A fusion of prose with a poetical narrative is employed; the latter is reserved to capture the immediacy of personal, emotive, and embodied storied experiences. This deeply intimate and dialogical story begins with a pedagogical experiment created to facilitate nursing students' understanding of critical social theory. Drawing upon Paulo Freire's work, the nursing teacher in a professional development course attempted to deconstruct power relations and cultivate an open and safe learning environment by sharing a poem that depicts her oppression. Students then anonymously wrote a word/statement about their oppression. The teacher created a composite poem from students' words and shared it with the class; it was a powerful moment that highlighted their shared humanity. As a way to further explore stories and consider how to preserve these words, a small group of students and the teacher formed the 'the oppression group'. Towards the end, we conclude an unfinished story by realizing that the chains of oppression are loosening and humanity is surfacing. There is still a camouflaging of an authentic self. There are still stories to be told. The group is not yet certain if a social representation of an authentic self is possible and if all stories can be told. It has become apparent that the personal can play out in social justice as enacted in the classroom between teacher and students and provides an entry point into the development of the capacity to be social agents in nursing. The group simultaneously concludes the story with both an ending and a threshold of social justice. © 2011 Blackwell Publishing Ltd.

  10. Function-related Secondary User Needs and Secondary Data? A Critical Examination of Some Central Concepts in the Modern Theory of Lexicographical Functions

    Directory of Open Access Journals (Sweden)

    Marcin Overgaard Ptaszynski

    2011-10-01

    Full Text Available

    Abstract: The aim of this article is to contribute to the development of the modern theory of lexi-cographical functions by offering a critical examination of the following concepts associated with it: primary needs, primary data, secondary needs, secondary data, function-related needs, and function-related data. By way of introduction, a presentation of the basic tenets of the theory is offered, followed by a description of the gen-eral characteristics of secondary needs and data. Next, on the basis of both a critical analysis of the theory and an examination of selected data types in existing lexicographical products, it is argued that all user needs and all data that satisfy those needs are function-related. The distinction between the concepts function-related and usage-related is thus rejected. Since this has serious implications for the relation between secondary needs and data on the one hand and primary needs and data on the other, this relation is subsequently reconsid-ered. This leads to a redefinition of all the concepts examined. It is also explained why an ideal state of lexico-graphy, where secondary needs and data do not exist, cannot be achieved in the real world.

    Keywords: DICTIONARY, LEXICOGRAPHY, LEXICOGRAPHICAL FUNCTION, PRIMARY NEED, PRIMARY DATA, SECONDARY NEED, SECONDARY DATA, FUNCTION-RELATED NEED, FUNCTION-RELATED DATA, EXTRA-LEXICOGRAPHICAL SITUATION, INTRA-LEXICOGRAPHICAL SITUATION, COMMUNICATIVE FUNCTION, COGNITIVE FUNCTION, OPERATIVE FUNCTION, TEXT RECEPTION, TEXT PRODUCTION, TRANSLATION

    Opsomming: Funksieverwante sekondêre gebruikersbehoeftes en sekon-dêre data? 'n Kritiese ondersoek na 'n aantal kernbegrippe in die moderne teorie van leksikografiese funksies. Die doel van hierdie artikel is om by te dra tot die ontwikkeling van die moderne teorie van leksikografiese funksies deur 'n kritiese ondersoek aan te bied van die volgende begrippe wat daarmee verbind word: primêre behoeftes, primêre data

  11. Symptom burden and its relationship to functional performance in patients with chronic obstructive pulmonary disease

    OpenAIRE

    Melhem, Omar

    2016-01-01

    The aim of this study was to explore symptom burden and its relationship to functional performance in patients with COPD. A descriptive, cross-sectional, correlational survey design was used and a sample of 214 patients with COPD. The sample was recruited from patients attending one of the major teaching hospitals in Dublin. Symptom burden was measured using the Memorial Symptom Assessment Scale (MSAS), and the functional performance was measured using the Functional Performance Inventory-Sho...

  12. Experimentation of RT-LOTOS for a critical function of a power plant instrumentation and control system

    International Nuclear Information System (INIS)

    Andriantsiiferana, L.; Courtiat, J.P.; De Oliveira, R.C.

    1996-01-01

    This document is the final report of the contract between LAAS-CNRS and the EdF Direction of Researches and Studies about the experimentation of RT-LOTOS formal description technique on a critical function of a nuclear power plant instrumentation and control system. This report comprises 4 parts: part 1 describes the RT-LOTOS (Real Time-Language of Temporal Ordering Specifications) tutorial and its RTL tool environment, the different RT-LOTOS operators and semantics, and the RTL tool main functionalities; part 2 deals with the methodology and the global architecture for the specification and validation of the CCT (Central Calculator for Treatment); part 3 gives more details about the different processes identified in the specification architecture and presents the main results obtained for the validation of the nominal functioning; part 4 describes some exceptional situations and shows how some failures and their associated recovery mechanisms can be modelled. (J.S.). 6 refs., 53 figs., 5 tabs., 2 appends

  13. Frank A. Beach award: programming of neuroendocrine function by early-life experience: a critical role for the immune system.

    Science.gov (United States)

    Bilbo, Staci D

    2013-05-01

    Many neuropsychiatric disorders are associated with a strong dysregulation of the immune system, and several have a striking etiology in development as well. Our recent evidence using a rodent model of neonatal Escherichia coli infection has revealed novel insight into the mechanisms underlying cognitive deficits in adulthood, and suggests that the early-life immune history of an individual may be critical to understanding the relative risk of developing later-life mental health disorders in humans. A single neonatal infection programs the function of immune cells within the brain, called microglia, for the life of the rodent such that an adult immune challenge results in exaggerated cytokine production within the brain and associated cognitive deficits. I describe the important role of the immune system, notably microglia, during brain development, and discuss some of the many ways in which immune activation during early brain development can affect the later-life outcomes of neural function, immune function, and cognition. Copyright © 2013 Elsevier Inc. All rights reserved.

  14. Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer

    Science.gov (United States)

    Carvalho, S; Catarino, TA; Dias, AM; Kato, M; Almeida, A; Hessling, B; Figueiredo, J; Gärtner, F; Sanches, JM; Ruppert, T; Miyoshi, E; Pierce, M; Carneiro, F; Kolarich, D; Seruca, R; Yamaguchi, Y; Taniguchi, N; Reis, CA; Pinho, SS

    2016-01-01

    E-cadherin is a central molecule in the process of gastric carcinogenesis and its posttranslational modifications by N-glycosylation have been described to induce a deleterious effect on cell adhesion associated with tumor cell invasion. However, the role that site-specific glycosylation of E-cadherin has in its defective function in gastric cancer cells needs to be determined. Using transgenic mice models and human clinical samples, we demonstrated that N-acetylglucosaminyltransferase V (GnT-V)-mediated glycosylation causes an abnormal pattern of E-cadherin expression in the gastric mucosa. In vitro models further indicated that, among the four potential N-glycosylation sites of E-cadherin, Asn-554 is the key site that is selectively modified with β1,6 GlcNAc-branched N-glycans catalyzed by GnT-V. This aberrant glycan modification on this specific asparagine site of E-cadherin was demonstrated to affect its critical functions in gastric cancer cells by affecting E-cadherin cellular localization, cis-dimer formation, molecular assembly and stability of the adherens junctions and cell–cell aggregation, which was further observed in human gastric carcinomas. Interestingly, manipulating this site-specific glycosylation, by preventing Asn-554 from receiving the deleterious branched structures, either by a mutation or by silencing GnT-V, resulted in a protective effect on E-cadherin, precluding its functional dysregulation and contributing to tumor suppression. PMID:26189796

  15. Task-relevant cognitive and motor functions are prioritized during prolonged speed-accuracy motor task performance.

    Science.gov (United States)

    Solianik, Rima; Satas, Andrius; Mickeviciene, Dalia; Cekanauskaite, Agne; Valanciene, Dovile; Majauskiene, Daiva; Skurvydas, Albertas

    2018-06-01

    This study aimed to explore the effect of prolonged speed-accuracy motor task on the indicators of psychological, cognitive, psychomotor and motor function. Ten young men aged 21.1 ± 1.0 years performed a fast- and accurate-reaching movement task and a control task. Both tasks were performed for 2 h. Despite decreased motivation, and increased perception of effort as well as subjective feeling of fatigue, speed-accuracy motor task performance improved during the whole period of task execution. After the motor task, the increased working memory function and prefrontal cortex oxygenation at rest and during conflict detection, and the decreased efficiency of incorrect response inhibition and visuomotor tracking were observed. The speed-accuracy motor task increased the amplitude of motor-evoked potentials, while grip strength was not affected. These findings demonstrate that to sustain the performance of 2-h speed-accuracy task under conditions of self-reported fatigue, task-relevant functions are maintained or even improved, whereas less critical functions are impaired.

  16. Functionalized nanostructures for enhanced photocatalytic performance under solar light

    Directory of Open Access Journals (Sweden)

    Liejin Guo

    2014-07-01

    Full Text Available Photocatalytic hydrogen production from water has been considered to be one of the most promising solar-to-hydrogen conversion technologies. In the last decade, various functionalized nanostructures were designed to address the primary requirements for an efficient photocatalytic generation of hydrogen by using solar energy: visible-light activity, chemical stability, appropriate band-edge characteristics, and potential for low-cost fabrication. Our aim is to present a short review of our recent attempts that center on the above requirements. We begin with a brief introduction of photocatalysts coupling two or more semiconductors, followed by a further discussion of the heterostructures with improved matching of both band structures and crystal lattices. We then elaborate on the heterostructure design of the targeted materials from macroscopic regulation of compositions and phases, to the more precise control at the nanoscale, i.e., materials with the same compositions but different phases with certain band alignment. We conclude this review with perspectives on nanostructure design that might direct future research of this technology.

  17. Improving the Performance of Semiconductor Sensor Devices Using Surface Functionalization

    Science.gov (United States)

    Rohrbaugh, Nathaniel W.

    As production and understanding of III-nitride growth has progressed, this class of material has been used for its semiconducting properties in the fields of computer processing, microelectronics, and LEDs. As understanding of materials properties has advanced, devices were fabricated to be sensitive to environmental surroundings such as pH, gas, or ionic concentration. Simultaneously the world of pharmaceuticals and environmental science has come to the age where the use of wearable devices and active environmental sensing can not only help us learn more about our surroundings, but help save lives. At the crossroads of these two fields work has been done in marrying the high stability and electrical properties of the III-nitrides with the needs of a growing sensor field for various environments and stimuli. Device architecture can only get one so far, and thus the need for well understood surface functionalization techniques has arisen in the field of III-nitride environmental sensing. Many existing schemes for functionalization involve chemistries that may be unfriendly to a biological environment, unstable in solution, or expensive to produce. One possible solution to these issues is the work presented here, which highlights a surface modification scheme utilizing phosphonic acid based chemistry and biomolecular attachment. This dissertation presents a set of studies and experiments quantifying and analyzing the response behaviors of AlGaN/GaN field effect transistor (FET) devices via their interfacial electronic properties. Additional investigation was done on the modification of these surfaces, effects of stressful environmental conditions, and the utility of the phosphonic acid surface treatments. Signals of AlGaN/GaN FETs were measured as IDrain values and in the earliest study an average signal increase of 96.43% was observed when surfaces were incubated in a solution of a known recognition peptide sequence (SVSVGMKPSPRP). This work showed that even without

  18. Maintaining sufficient nanos is a critical function for polar granule component in the specification of primordial germ cells.

    Science.gov (United States)

    Deshpande, Girish; Spady, Emma; Goodhouse, Joe; Schedl, Paul

    2012-11-01

    Primordial germ cells (PGC) are the precursors of germline stem cells. In Drosophila, PGC specification is thought to require transcriptional quiescence and three genes, polar granule component (pgc), nanos (nos), and germ cell less (gcl) function to downregulate Pol II transcription. While it is not understood how nos or gcl represses transcription, pgc does so by inhibiting the transcription elongation factor b (P-TEFb), which is responsible for phosphorylating Ser2 residues in the heptad repeat of the C-terminal domain (CTD) of the largest Pol II subunit. In the studies reported here, we demonstrate that nos are a critical regulatory target of pgc. We show that a substantial fraction of the PGCs in pgc embryos have greatly reduced levels of Nos protein and exhibit phenotypes characteristic of nos PGCs. Lastly, restoring germ cell-specific expression of Nos is sufficient to ameliorate the pgc phenotype.

  19. THE FEATURES OF AIRCRAFT FUNCTIONAL SYSTEMS PERFORMANCE MONITORING

    Directory of Open Access Journals (Sweden)

    Stanislav Alexandrovich Krotov

    2017-01-01

    Full Text Available The key steps of aircraft essential parameters and events monitoring during its operation are considered in the arti- cle. Conditions for specific risk monitoring are also presented.The notion of fail-safe feature of aircraft functional systems is analysed, and the necessity of continuous process of safety flight level estimate is shown. The method of quantitative assessment of key events and risks probabilities with the use of modern software is proposed. This method contains 5 basic stages: The monitoring parameters setting - this stage is initial and begins with the consideration of organization safety cul- ture, the main purposes and problems determination, the basic parameters and characteristics forming which are to be monitored. The event monitoring in operation - on this stage continuous process of key events searching and monitoring which are a thing of importance within the framework of the established problems takes place. This process is closely relat- ed to parameters monitoring set on the first stage. The event and risk estimate - this stage begins directly after the event has been discovered. The estimate pro- cess is as long as it is required to identify the event gravity. It also contains the preliminary risk estimate for using in priori- tization of initial expanded estimate and in the working out of plan for activities realization. The working out of plan for activities - on this stage correction data is determined that will make changes to aero- technics working out, operation, maintenance and to staff training directly in linkage to the problem event identified earlier. The activity carrying-out - the realization of actions according to the activity plan. This stage concludes priori- tization, planning and problem carrying-out. The dependence set between the probability of failure situations and the degree of their danger is shown. The key factors which are subject to be estimated while aircraft operating and which aim with

  20. IEEE 802.15.4 Frame Aggregation Enhancement to Provide High Performance in Life-Critical Patient Monitoring Systems.

    Science.gov (United States)

    Akbar, Muhammad Sajjad; Yu, Hongnian; Cang, Shuang

    2017-01-28

    In wireless body area sensor networks (WBASNs), Quality of Service (QoS) provision for patient monitoring systems in terms of time-critical deadlines, high throughput and energy efficiency is a challenging task. The periodic data from these systems generates a large number of small packets in a short time period which needs an efficient channel access mechanism. The IEEE 802.15.4 standard is recommended for low power devices and widely used for many wireless sensor networks applications. It provides a hybrid channel access mechanism at the Media Access Control (MAC) layer which plays a key role in overall successful transmission in WBASNs. There are many WBASN's MAC protocols that use this hybrid channel access mechanism in variety of sensor applications. However, these protocols are less efficient for patient monitoring systems where life critical data requires limited delay, high throughput and energy efficient communication simultaneously. To address these issues, this paper proposes a frame aggregation scheme by using the aggregated-MAC protocol data unit (A-MPDU) which works with the IEEE 802.15.4 MAC layer. To implement the scheme accurately, we develop a traffic patterns analysis mechanism to understand the requirements of the sensor nodes in patient monitoring systems, then model the channel access to find the performance gap on the basis of obtained requirements, finally propose the design based on the needs of patient monitoring systems. The mechanism is initially verified using numerical modelling and then simulation is conducted using NS2.29, Castalia 3.2 and OMNeT++. The proposed scheme provides the optimal performance considering the required QoS.

  1. High-performance functional ecopolymers based on flora and fauna.

    Science.gov (United States)

    Kaneko, Tatsuo

    2007-01-01

    Liquid crystalline (LC) polymers of rigid monomers based on flora and fauna were prepared by in-bulk polymerization. Para-coumaric (p-coumaric) acid [4-hydroxycinnamic acid (4HCA)] and its derivatives were selected as phytomonomers and bile acids were selected as biomonomers. The 4HCA homopolymer showed a thermotropic LC phase only in a state of low molecular weight. The copolymers of 4HCA with bile acids such as lithocholic acid (LCA) and cholic acid (CA) showed excellent cell compatibilities but low molecular weights. However, P(4HCA-co-CA)s allowed LC spinning to create molecularly oriented biofibers, presumably due to the chain entanglement that occurs during in-bulk chain propagation into hyperbranching architecture. P[4HCA-co-3,4-dihydroxycinnamic acid (DHCA)]s showed high molecular weight, high mechanical strength, high Young's modulus, and high softening temperature, which may be achieved through the entanglement by in-bulk formation of hyperbranching, rigid structures. P(4HCA-co-DHCA)s showed a smooth hydrolysis, in-soil degradation, and photo-tunable hydrolysis. Thus, P(4HCA-co-DHCA)s might be applied as an environmentally degradable plastic with extremely high performance.

  2. Separation of polyethylene glycols and amino-terminated polyethylene glycols by high-performance liquid chromatography under near critical conditions.

    Science.gov (United States)

    Wei, Y-Z; Zhuo, R-X; Jiang, X-L

    2016-05-20

    The separation and characterization of polyethylene glycols (PEGs) and amino-substituted derivatives on common silica-based reversed-phase packing columns using isocratic elution is described. This separation is achieved by liquid chromatography under the near critical conditions (LCCC), based on the number of amino functional end groups without obvious effect of molar mass for PEGs. The mobile phase is acetonitrile in water with an optimal ammonium acetate buffer. The separation mechanism of PEG and amino-substituted PEG under the near LCCC on silica-based packing columns is confirmed to be ion-exchange interaction. Under the LCCC of PEG backbone, with fine tune of buffer concentration, the retention factor ratios for benzylamine and phenol in buffered mobile phases, α(benzylamine/phenol)-values, were used to assess the ion-exchange capacity on silica-based reversed-phase packing columns. To the best of our knowledge, this is the first report on separation of amino-functional PEGs independent of the molar mass by isocratic elution using common C18 or phenyl reversed-phase packing columns. Copyright © 2016 Elsevier B.V. All rights reserved.

  3. Criticality Model

    International Nuclear Information System (INIS)

    Alsaed, A.

    2004-01-01

    The ''Disposal Criticality Analysis Methodology Topical Report'' (YMP 2003) presents the methodology for evaluating potential criticality situations in the monitored geologic repository. As stated in the referenced Topical Report, the detailed methodology for performing the disposal criticality analyses will be documented in model reports. Many of the models developed in support of the Topical Report differ from the definition of models as given in the Office of Civilian Radioactive Waste Management procedure AP-SIII.10Q, ''Models'', in that they are procedural, rather than mathematical. These model reports document the detailed methodology necessary to implement the approach presented in the Disposal Criticality Analysis Methodology Topical Report and provide calculations utilizing the methodology. Thus, the governing procedure for this type of report is AP-3.12Q, ''Design Calculations and Analyses''. The ''Criticality Model'' is of this latter type, providing a process evaluating the criticality potential of in-package and external configurations. The purpose of this analysis is to layout the process for calculating the criticality potential for various in-package and external configurations and to calculate lower-bound tolerance limit (LBTL) values and determine range of applicability (ROA) parameters. The LBTL calculations and the ROA determinations are performed using selected benchmark experiments that are applicable to various waste forms and various in-package and external configurations. The waste forms considered in this calculation are pressurized water reactor (PWR), boiling water reactor (BWR), Fast Flux Test Facility (FFTF), Training Research Isotope General Atomic (TRIGA), Enrico Fermi, Shippingport pressurized water reactor, Shippingport light water breeder reactor (LWBR), N-Reactor, Melt and Dilute, and Fort Saint Vrain Reactor spent nuclear fuel (SNF). The scope of this analysis is to document the criticality computational method. The criticality

  4. Entrepreneurial orientation and firm performance : the mediating role of functional performances

    NARCIS (Netherlands)

    Rezaei, J.; Ortt, J.R.

    2018-01-01

    Purpose: Earlier studies have generally shown a positive relationship between entrepreneurial orientation (EO) and the overall performance of the firm. The purpose of this paper is to understand in more detail how EO influences firm performance. It adds to the literature by distinguishing

  5. Human feeding biomechanics: performance, variation, and functional constraints

    Directory of Open Access Journals (Sweden)

    Justin A. Ledogar

    2016-07-01

    dislocation and constrained the maximum recruitment levels of the masticatory muscles on the balancing (non-biting side of the head. Our results do not necessarily conflict with the hypothesis that anterior tooth (incisors, canines, premolars biting could have been selectively important in humans, although the reduced size of the premolars in humans has been shown to increase the risk of tooth crown fracture. We interpret our results to suggest that human craniofacial evolution was probably not driven by selection for high magnitude unilateral biting, and that increased masticatory muscle efficiency in humans is likely to be a secondary byproduct of selection for some function unrelated to forceful biting behaviors. These results are consistent with the hypothesis that a shift to softer foods and/or the innovation of pre-oral food processing techniques relaxed selective pressures maintaining craniofacial features that favor forceful biting and chewing behaviors, leading to the characteristically small and gracile faces of modern humans.

  6. Human feeding biomechanics: performance, variation, and functional constraints

    Science.gov (United States)

    Dechow, Paul C.; Wang, Qian; Gharpure, Poorva H.; Baab, Karen L.; Smith, Amanda L.; Weber, Gerhard W.; Grosse, Ian R.; Ross, Callum F.; Richmond, Brian G.; Wright, Barth W.; Byron, Craig; Wroe, Stephen; Strait, David S.

    2016-01-01

    constrained the maximum recruitment levels of the masticatory muscles on the balancing (non-biting) side of the head. Our results do not necessarily conflict with the hypothesis that anterior tooth (incisors, canines, premolars) biting could have been selectively important in humans, although the reduced size of the premolars in humans has been shown to increase the risk of tooth crown fracture. We interpret our results to suggest that human craniofacial evolution was probably not driven by selection for high magnitude unilateral biting, and that increased masticatory muscle efficiency in humans is likely to be a secondary byproduct of selection for some function unrelated to forceful biting behaviors. These results are consistent with the hypothesis that a shift to softer foods and/or the innovation of pre-oral food processing techniques relaxed selective pressures maintaining craniofacial features that favor forceful biting and chewing behaviors, leading to the characteristically small and gracile faces of modern humans. PMID:27547550

  7. Association between functional performance and executive cognitive functions in an elderly population including patients with low ankle–brachial index

    Science.gov (United States)

    Ferreira, Naomi Vidal; Cunha, Paulo Jannuzzi; da Costa, Danielle Irigoyen; dos Santos, Fernando; Costa, Fernando Oliveira; Consolim-Colombo, Fernanda; Irigoyen, Maria Cláudia

    2015-01-01

    Introduction Peripheral arterial disease, as measured by the ankle–brachial index (ABI), is prevalent among the elderly, and is associated with functional performance, assessed by the 6-minute walk test (6MWT). Executive cognitive function (ECF) impairments are also prevalent in this population, but no existing study has investigated the association between ECF and functional performance in an elderly population including individuals with low ABI. Aim To investigate the association between functional performance, as measured by the 6MWT, and loss in ECF, in an elderly sample including individuals with low ABI. Method The ABI group was formed by 26 elderly individuals with low ABI (mean ABI: 0.63±0.19), and the control group was formed by 40 elderly individuals with normal ABI (mean ABI: 1.08±0.07). We analyzed functional performance using the 6MWT, global cognition using the Mini-Mental State Examination (MMSE), and ECF using the Digit Span for assessing attention span and working memory, the Stroop Color Word Test (SCWT) for assessing information processing speed and inhibitory control/impulsivity, and the Controlled Oral Word Association Test (COWAT) for assessing semantic verbal fluency and phonemic verbal fluency. We also used a factor analysis on all of the ECF tests (global ECF). Results Before adjustment, the ABI group performed worse on global cognition, attention span, working memory, inhibitory control/impulsivity, semantic verbal fluency, and phonemic verbal fluency. After adjustment, the ABI group performance remained worse for working memory and semantic verbal fluency. In a simple correlation analysis including all of the subjects, the 6MWT was associated with global cognition, attention span, working memory, information processing speed, inhibitory control/impulsivity, semantic verbal fluency, and global ECF. After adjustment, all the associations remained statistically significant. Conclusion This study found an independent association between

  8. Executive Functions, Memory, and Social Cognitive Deficits and Recovery in Chronic Alcoholism: A Critical Review to Inform Future Research.

    Science.gov (United States)

    Le Berre, Anne-Pascale; Fama, Rosemary; Sullivan, Edith V

    2017-08-01

    Alcoholism is a complex and dynamic disease, punctuated by periods of abstinence and relapse, and influenced by a multitude of vulnerability factors. Chronic excessive alcohol consumption is associated with cognitive deficits, ranging from mild to severe, in executive functions, memory, and metacognitive abilities, with associated impairment in emotional processes and social cognition. These deficits can compromise efforts in initiating and sustaining abstinence by hampering efficacy of clinical treatment and can obstruct efforts in enabling good decision making success in interpersonal/social interactions, and awareness of cognitive and behavioral dysfunctions. Despite evidence for differences in recovery levels of selective cognitive processes, certain deficits can persist even with prolonged sobriety. Herein is presented a review of alcohol-related cognitive impairments affecting component processes of executive functioning, memory, and the recently investigated cognitive domains of metamemory, social cognition, and emotional processing; also considered are trajectories of cognitive recovery with abstinence. Finally, in the spirit of critical review, limitations of current knowledge are noted and avenues for new research efforts are proposed that focus on (i) the interaction among emotion-cognition processes and identification of vulnerability factors contributing to the development of emotional and social processing deficits and (ii) the time line of cognitive recovery by tracking alcoholism's dynamic course of sobriety and relapse. Knowledge about the heterochronicity of cognitive recovery in alcoholism has the potential of indicating at which points during recovery intervention may be most beneficial. Copyright © 2017 by the Research Society on Alcoholism.

  9. Sturmian functions in a L{sup 2} basis: Critical nuclear charge for N-electron atoms

    Energy Technology Data Exchange (ETDEWEB)

    Frapiccini, A.L. [Departamento de Fisica, Universidad Nacional del Sur, Bahia Blanca (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas (Argentina)], E-mail: afrapic@uns.edu.ar; Gasaneo, G. [Departamento de Fisica, Universidad Nacional del Sur, Bahia Blanca (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas (Argentina); Colavecchia, F.D. [Centro Atomico Bariloche, San Carlos de Bariloche, Rio Negro (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas (Argentina); Mitnik, D. [Instituto de Astronomia y Fisica del Espacio and, Departamento de Fisica, Universidad de Buenos Aires (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas (Argentina)

    2007-10-15

    Two particle Sturmian functions [M. Rotenberg, Ann. Phys., NY 19 (1962) 262; S.V. Khristenko, Theor. Math. Fiz. 22 (1975) 31 (Engl. Transl. Theor. Math. Phys. 22, 21)] for a short range potentials are obtained by expanding the solution of the Schroedinger equation in a finite L{sup 2}Laguerre-type basis. These functions are chosen to satisfy certain boundary conditions, such as regularity at the origin and the correct asymptotic behavior according to the energy domain: exponential decay for negative energy and outgoing (incoming or standing wave) for positive energy. The set of eigenvalues obtained is discrete for both positive and negative energies. This Sturmian basis is used to solve the Schroedinger equation for a one-particle model potential [A.V. Sergeev, S. Kais, J. Quant. Chem. 75 (1999) 533] to describe the motion of a loosely bound electron in a multielectron atom. Values of the two parameters of the potential are computed to represent the Helium isoelectronic series and the critical nuclear charge Z{sub c} is found, in good agreement with previous calculations.

  10. Effects of Delayed Enteral Nutrition on Inflammatory Responses and Immune Function Competence in Critically Ill Patients with Prolonged Fasting.

    Science.gov (United States)

    Xi, Fengchan; Li, Ning; Geng, Yanxia; Gao, Tao; Zhang, Juanjuan; Jun, Tanshan; Lin, Zhiliang; Li, Weiqin; Zhu, Weiming; Yu, Wenkui; Li, Jieshou

    2014-05-01

    Although different studies suggest that early enteral nutrition (EEN) has benefits in reducing infectious complications, there is no data that addresses whether delayed enteral nutrition (EN) is detrimental and if it may have effects on inflammatory responses and immune function. Forty-five critically ill patients with long fasting were randomly allocated in two groups according to the type of nutritional support. The first group included patients assuming a standard enteral nutrition (EN, n = 22) and the second group assuming a parenteral nutrition (PN, n = 23). The daily nutritional amount was 25 kcal (105 kJ)/kg for all patients. The inflammatory markers white blood cells (WBC), C-reactive protein (CRP), TNF-α, IL-1-β, IL-6, IL-4, IL- 10 and the immune T-lymphocyte sub-populations CD3+, CD4+, CD8+, and HLA-DR+ were evaluated at day 1, and after 2, 3 and 7 days. IL-4, IL-10, CD3+, CD4+, CD8+ and the CD4+/CD8+ ratio were not statistically different between the two groups. WBC and TNF-α in EN patients were higher than those in PN after 3 and 7 days (P fasting increased systemic inflammatory responses, whereas EN could modify immune function, therefore reducing hospital stay and costs.

  11. Genome-wide mouse mutagenesis reveals CD45-mediated T cell function as critical in protective immunity to HSV-1.

    Directory of Open Access Journals (Sweden)

    Grégory Caignard

    2013-09-01

    Full Text Available Herpes simplex encephalitis (HSE is a lethal neurological disease resulting from infection with Herpes Simplex Virus 1 (HSV-1. Loss-of-function mutations in the UNC93B1, TLR3, TRIF, TRAF3, and TBK1 genes have been associated with a human genetic predisposition to HSE, demonstrating the UNC93B-TLR3-type I IFN pathway as critical in protective immunity to HSV-1. However, the TLR3, UNC93B1, and TRIF mutations exhibit incomplete penetrance and represent only a minority of HSE cases, perhaps reflecting the effects of additional host genetic factors. In order to identify new host genes, proteins and signaling pathways involved in HSV-1 and HSE susceptibility, we have implemented the first genome-wide mutagenesis screen in an in vivo HSV-1 infectious model. One pedigree (named P43 segregated a susceptible trait with a fully penetrant phenotype. Genetic mapping and whole exome sequencing led to the identification of the causative nonsense mutation L3X in the Receptor-type tyrosine-protein phosphatase C gene (Ptprc(L3X, which encodes for the tyrosine phosphatase CD45. Expression of MCP1, IL-6, MMP3, MMP8, and the ICP4 viral gene were significantly increased in the brain stems of infected Ptprc(L3X mice accounting for hyper-inflammation and pathological damages caused by viral replication. Ptprc(L3X mutation drastically affects the early stages of thymocytes development but also the final stage of B cell maturation. Transfer of total splenocytes from heterozygous littermates into Ptprc(L3X mice resulted in a complete HSV-1 protective effect. Furthermore, T cells were the only cell population to fully restore resistance to HSV-1 in the mutants, an effect that required both the CD4⁺ and CD8⁺ T cells and could be attributed to function of CD4⁺ T helper 1 (Th1 cells in CD8⁺ T cell recruitment to the site of infection. Altogether, these results revealed the CD45-mediated T cell function as potentially critical for infection and viral spread to the

  12. Financial performance monitoring of the technical efficiency of critical access hospitals: a data envelopment analysis and logistic regression modeling approach.

    Science.gov (United States)

    Wilson, Asa B; Kerr, Bernard J; Bastian, Nathaniel D; Fulton, Lawrence V

    2012-01-01

    From 1980 to 1999, rural designated hospitals closed at a disproportionally high rate. In response to this emergent threat to healthcare access in rural settings, the Balanced Budget Act of 1997 made provisions for the creation of a new rural hospital--the critical access hospital (CAH). The conversion to CAH and the associated cost-based reimbursement scheme significantly slowed the closure rate of rural hospitals. This work investigates which methods can ensure the long-term viability of small hospitals. This article uses a two-step design to focus on a hypothesized relationship between technical efficiency of CAHs and a recently developed set of financial monitors for these entities. The goal is to identify the financial performance measures associated with efficiency. The first step uses data envelopment analysis (DEA) to differentiate efficient from inefficient facilities within a data set of 183 CAHs. Determining DEA efficiency is an a priori categorization of hospitals in the data set as efficient or inefficient. In the second step, DEA efficiency is the categorical dependent variable (efficient = 0, inefficient = 1) in the subsequent binary logistic regression (LR) model. A set of six financial monitors selected from the array of 20 measures were the LR independent variables. We use a binary LR to test the null hypothesis that recently developed CAH financial indicators had no predictive value for categorizing a CAH as efficient or inefficient, (i.e., there is no relationship between DEA efficiency and fiscal performance).

  13. 29 CFR 825.123 - Unable to perform the functions of the position.

    Science.gov (United States)

    2010-07-01

    ... position within the meaning of the Americans with Disabilities Act (ADA), as amended, 42 U.S.C. 12101 et... 29 Labor 3 2010-07-01 2010-07-01 false Unable to perform the functions of the position. 825.123... Act § 825.123 Unable to perform the functions of the position. (a) Definition. An employee is “unable...

  14. Why performance appraisal does not lead to performance improvement : Excellent performance as a function of uniqueness instead of uniformity

    NARCIS (Netherlands)

    van Woerkom, M.; de Bruijn, M.J.

    Dissatisfaction with performance appraisal is at an all-time high (Adler et al., 2016). In this commentary we argue that one of the reasons why performance appraisal is unable to get the most out of employees is the way in which employees are evaluated against a uniform set of criteria, leading to a

  15. A comparison of educational strategies for the acquisition of nursing student’s performance and critical thinking: simulation-based training vs. integrated training (simulation and critical thinking strategies

    Directory of Open Access Journals (Sweden)

    Nahid Zarifsanaiey

    2016-11-01

    Full Text Available Abstract Background There is a need to change the focus of nursing education from traditional teacher-centered training programs to student-centered active methods. The integration of the two active learning techniques will improve the effectiveness of training programs. The objective of this study is to compare the effects of the integrated training (simulation and critical thinking strategies and simulation-based training on the performance level and critical thinking ability of nursing students. Methods The present quasi-experimental study was performed in 2014 on 40 students who were studying practical nursing principles and skills course in the first half of the academic year in Shiraz University of Medical Sciences. Students were randomly divided into control (n = 20 and experimental (n = 20 groups. After training students through simulation and integrated education (simulation and critical thinking strategies, the students' critical thinking ability and performance were evaluated via the use of California Critical Thinking Ability Questionnaire B (CCTST and Objective Structured Clinical Examination (OSCE comprising 10 stations, respectively. The external reliability of the California Critical Thinking questionnaire was reported by Case B.to be between 0.78 and 0.80 and the validity of OSCE was approved by 5 members of the faculty. Furthermore, by using Split Half method (the correlation between odd and even stations, the reliability of the test was approved with correlation coefficient of 0.66. Data were analyzed using t-test and Mann–Whitney test. A significance level of 0.05 was considered to be statistically significant. Results The mean scores of the experimental group performance level were higher than the mean score of the control group performance level. This difference was statistically significant and students in the experimental group in OSCE stations had significantly higher performance than the control group (P <0

  16. What's in a Name? A Critical Literacy and Functional Linguistic Analysis of Immigrant Acculturation in Contemporary Picture Books

    Science.gov (United States)

    Sembiante, Sabrina F.; Baxley, Traci P.; Cavallaro, Christina J.

    2018-01-01

    This article investigates how immigrant children's acculturation experiences are characterized through the symbolic literary feature of name in children's literature and how the language of the text functions to communicate these messages. We draw on the theoretical frameworks of Critical Literacy (CL) and Systemic Functional Linguistics (SFL) to…

  17. Critical assessment of the performance of electronic moisture analyzers for small amounts of environmental samples and biological reference materials.

    Science.gov (United States)

    Krachler, M

    2001-12-01

    Two electronic moisture analyzers were critically evaluated with regard to their suitability for determining moisture in small amounts (environmental matrices such as leaves, needles, soil, peat, sediments, and sewage sludge, as well as various biological reference materials. To this end, several homogeneous bulk materials were prepared which were subsequently employed for the development and optimization of all analytical procedures. The key features of the moisture analyzers included a halogen or ceramic heater and an integrated balance with a resolution of 0.1 mg, which is an essential prerequisite for obtaining precise results. Oven drying of the bulk materials in a conventional oven at 105 degrees C until constant mass served as reference method. A heating temperature of 65degrees C was found to provide accurate and precise results for almost all matrices investigated. To further improve the accuracy and precision, other critical parameters such as handling of sample pans, standby temperature, and measurement delay were optimized. Because of its ponderous heating behavior, the performance of the ceramic radiator was inferior to that of the halogen heater, which produced moisture results comparable to those obtained by oven drying. The developed drying procedures were successfully applied to the fast moisture analysis (1.4-6.3 min) of certified biological reference materials of similar provenance to the investigated the bulk materials. Moisture results for 200 mg aliquots ranged from 1.4 to 7.8% and good agreement was obtained between the recommended drying procedure for the reference materials and the electronic moisture analyzers with absolute uncertainties amounting to 0.1% and 0.2-0.3%, respectively.

  18. Representation of the Physiological Factors Contributing to Postflight Changes in Functional Performance Using Motion Analysis Software

    Science.gov (United States)

    Parks, Kelsey

    2010-01-01

    Astronauts experience changes in multiple physiological systems due to exposure to the microgravity conditions of space flight. To understand how changes in physiological function influence functional performance, a testing procedure has been developed that evaluates both astronaut postflight functional performance and related physiological changes. Astronauts complete seven functional and physiological tests. The objective of this project is to use motion tracking and digitizing software to visually display the postflight decrement in the functional performance of the astronauts. The motion analysis software will be used to digitize astronaut data videos into stick figure videos to represent the astronauts as they perform the Functional Tasks Tests. This project will benefit NASA by allowing NASA scientists to present data of their neurological studies without revealing the identities of the astronauts.

  19. Relationship between functional vision and balance and mobility performance in community-dwelling older adults

    OpenAIRE

    Aartolahti, Eeva; Häkkinen, Arja; Lönnroos, Eija; Kautiainen, Hannu; Sulkava, Raimo; Hartikainen, Sirpa

    2013-01-01

    Background and Aims: Vision is an important prerequisite for balance control and mobility. The role of objectively measured visual functions has been previously studied but less is known about associations of functional vision. That refers to selfperceived vision-based ability to perform daily activities. The aim was to investigate the relationship between functional vision and balance and mobility performance in a community-based sample of older adults. Methods: This study ...

  20. Critical point of gas-liquid type phase transition and phase equilibrium functions in developed two-component plasma model.

    Science.gov (United States)

    Butlitsky, M A; Zelener, B B; Zelener, B V

    2014-07-14

    A two-component plasma model, which we called a "shelf Coulomb" model has been developed in this work. A Monte Carlo study has been undertaken to calculate equations of state, pair distribution functions, internal energies, and other thermodynamics properties. A canonical NVT ensemble with periodic boundary conditions was used. The motivation behind the model is also discussed in this work. The "shelf Coulomb" model can be compared to classical two-component (electron-proton) model where charges with zero size interact via a classical Coulomb law. With important difference for interaction of opposite charges: electrons and protons interact via the Coulomb law for large distances between particles, while interaction potential is cut off on small distances. The cut off distance is defined by an arbitrary ɛ parameter, which depends on system temperature. All the thermodynamics properties of the model depend on dimensionless parameters ɛ and γ = βe(2)n(1/3) (where β = 1/kBT, n is the particle's density, kB is the Boltzmann constant, and T is the temperature) only. In addition, it has been shown that the virial theorem works in this model. All the calculations were carried over a wide range of dimensionless ɛ and γ parameters in order to find the phase transition region, critical point, spinodal, and binodal lines of a model system. The system is observed to undergo a first order gas-liquid type phase transition with the critical point being in the vicinity of ɛ(crit) ≈ 13(T(*)(crit) ≈ 0.076), γ(crit) ≈ 1.8(v(*)(crit) ≈ 0.17), P(*)(crit) ≈ 0.39, where specific volume v* = 1/γ(3) and reduced temperature T(*) = ɛ(-1).

  1. Physical Performance Is Associated with Executive Functioning in Older African American Women

    Directory of Open Access Journals (Sweden)

    Brooke C. Schneider

    2011-01-01

    Full Text Available An older adult's ability to perform physical tasks is predictive of disability onset and is associated with declines in cognition. Risk factors for physical performance declines among African Americans, a group with the highest rates of disability, remain understudied. This study sought to identify demographic, health, and cognitive factors associated with lower-extremity physical performance in a sample of 106 African American women ages 56 to 91. After controlling for global cognitive functioning (Mini Mental State Exam, physical performance was associated with executive functioning (Stroop Color/Word, but not visuospatial construction (WASI Block Design or processing speed (Trail Making Test, Part A. Executive functioning remained associated with physical performance after entry of demographic variables, exercise, depression, disease burden, and body mass index (BMI. Age, and BMI were also significant in this model. Executive functioning, age and BMI are associated with lower-extremity physical performance among older African American women.

  2. Performance of critical care prognostic scoring systems in low and middle-income countries: a systematic review.

    Science.gov (United States)

    Haniffa, Rashan; Isaam, Ilhaam; De Silva, A Pubudu; Dondorp, Arjen M; De Keizer, Nicolette F

    2018-01-26

    Prognostic models-used in critical care medicine for mortality predictions, for benchmarking and for illness stratification in clinical trials-have been validated predominantly in high-income countries. These results may not be reproducible in low or middle-income countries (LMICs), not only because of different case-mix characteristics but also because of missing predictor variables. The study objective was to systematically review literature on the use of critical care prognostic models in LMICs and assess their ability to discriminate between survivors and non-survivors at hospital discharge of those admitted to intensive care units (ICUs), their calibration, their accuracy, and the manner in which missing values were handled. The PubMed database was searched in March 2017 to identify research articles reporting the use and performance of prognostic models in the evaluation of mortality in ICUs in LMICs. Studies carried out in ICUs in high-income countries or paediatric ICUs and studies that evaluated disease-specific scoring systems, were limited to a specific disease or single prognostic factor, were published only as abstracts, editorials, letters and systematic and narrative reviews or were not in English were excluded. Of the 2233 studies retrieved, 473 were searched and 50 articles reporting 119 models were included. Five articles described the development and evaluation of new models, whereas 114 articles externally validated Acute Physiology and Chronic Health Evaluation, the Simplified Acute Physiology Score and Mortality Probability Models or versions thereof. Missing values were only described in 34% of studies; exclusion and or imputation by normal values were used. Discrimination, calibration and accuracy were reported in 94.0%, 72.4% and 25% respectively. Good discrimination and calibration were reported in 88.9% and 58.3% respectively. However, only 10 evaluations that reported excellent discrimination also reported good calibration

  3. Sleep Disturbance, Daytime Symptoms, and Functional Performance in Patients With Stable Heart Failure: A Mediation Analysis.

    Science.gov (United States)

    Jeon, Sangchoon; Redeker, Nancy S

    2016-01-01

    Sleep disturbance is common among patients with heart failure (HF) who also experience symptom burden and poor functional performance. We evaluated the extent to which sleep-related, daytime symptoms (fatigue, excessive daytime sleepiness, and depressive symptoms) mediate the relationship between sleep disturbance and functional performance among patients with stable HF. We recruited patients with stable HF for this secondary analysis of data from a cross-sectional, observational study. Participants completed unattended ambulatory polysomnography from which the Respiratory Disturbance Index was calculated, along with a Six-Minute Walk Test, questionnaires to elicit sleep disturbance (Pittsburgh Sleep Quality Index, Insomnia Symptoms from the Sleep Habits Questionnaire), daytime symptoms (Center for Epidemiologic Studies Depression Scale, Global Fatigue Index, Epworth Sleepiness Scale), and self-reported functional performance (Medical Outcomes Study SF36 V2 Physical Function Scale). We used structural equation modeling with latent variables for the key analysis. Follow-up, exploratory regression analysis with bootstrapped samples was used to examine the extent to which individual daytime symptoms mediated effects of sleep disturbance on functional performance after controlling for clinical and demographic covariates. The sample included 173 New York Heart Association Class I-IV HF patients (n = 60/34.7% women; M = 60.7, SD = 16.07 years of age). Daytime symptoms mediated the relationship between sleep disturbance and functional performance. Fatigue and depression mediated the relationship between insomnia symptoms and self-reported functional performance, whereas fatigue and sleepiness mediated the relationship between sleep quality and functional performance. Sleepiness mediated the relationship between the respiratory index and self-reported functional performance only in people who did not report insomnia. Daytime symptoms explain the relationships between sleep

  4. Functional Task Test: 3. Skeletal Muscle Performance Adaptations to Space Flight

    Science.gov (United States)

    Ryder, Jeffrey W.; Wickwire, P. J.; Buxton, R. E.; Bloomberg, J. J.; Ploutz-Snyder, L.

    2011-01-01

    The functional task test is a multi-disciplinary study investigating how space-flight induced changes to physiological systems impacts functional task performance. Impairment of neuromuscular function would be expected to negatively affect functional performance of crewmembers following exposure to microgravity. This presentation reports the results for muscle performance testing in crewmembers. Functional task performance will be presented in the abstract "Functional Task Test 1: sensory motor adaptations associated with postflight alternations in astronaut functional task performance." METHODS: Muscle performance measures were obtained in crewmembers before and after short-duration space flight aboard the Space Shuttle and long-duration International Space Station (ISS) missions. The battery of muscle performance tests included leg press and bench press measures of isometric force, isotonic power and total work. Knee extension was used for the measurement of central activation and maximal isometric force. Upper and lower body force steadiness control were measured on the bench press and knee extension machine, respectively. Tests were implemented 60 and 30 days before launch, on landing day (Shuttle crew only), and 6, 10 and 30 days after landing. Seven Space Shuttle crew and four ISS crew have completed the muscle performance testing to date. RESULTS: Preliminary results for Space Shuttle crew reveal significant reductions in the leg press performance metrics of maximal isometric force, power and total work on R+0 (pperformance metrics were observed in returning Shuttle crew and these adaptations are likely contributors to impaired functional tasks that are ambulatory in nature (See abstract Functional Task Test: 1). Interestingly, no significant changes in central activation capacity were detected. Therefore, impairments in muscle function in response to short-duration space flight are likely myocellular rather than neuromotor in nature.

  5. Chewing gum and cognitive performance: a case of a functional food with function but no food?

    Science.gov (United States)

    Scholey, Andrew

    2004-10-01

    Recent reports suggest that enhancement of memory performance while chewing gum is a fairly robust phenomenon. The processes underlying the effect are not known, but may involve glucose delivery, context-dependent effects and arousal mechanisms amongst others. This brief commentary outlines the main findings from these studies and raises some issues regarding interpretation, methodology and future research directions.

  6. Modeling the Non-functional Requirements in the Context of Usability, Performance, Safety and Security

    OpenAIRE

    Sadiq, Mazhar

    2007-01-01

    Requirement engineering is the most significant part of the software development life cycle. Until now great emphasis has been put on the maturity of the functional requirements. But with the passage of time it reveals that the success of software development does not only pertain to the functional requirements rather non-functional requirements should also be taken into consideration. Among the non-functional requirements usability, performance, safety and security are considered important. ...

  7. A Critical Review of Bioactive Food Components, and of their Functional Mechanisms, Biological Effects and Health Outcomes.

    Science.gov (United States)

    Perez-Gregorio, Rosa; Simal-Gandara, Jesus

    2017-01-01

    Eating behaviours are closely related to some medical conditions potentially leading to death such as cancer, cardiovascular disease and diabetes. Healthy eating practices, maintaining a normal weight, and regular physical activity could prevent up to 80% of coronary heart disease, 90% of type-2 diabetes and onethird of all cancers [1]. Over the last two decades, the food industry has invested much effort in research and development of healthier, more nutritious foods. These foods are frequently designated "functional" when they contain nutritional components required for healthy living or "nutraceuticals" when intended to treat or prevent disease or disorders through a variety of bioactive (e.g., antioxidant, antimicrobial, immunomodulatory, hypocholesterolaemic) functions that are performed by functional enzymes, probiotics, prebiotics, fibres, phytosterols, peptides, proteins, isoflavones, saponins or phytic acid, among other substances. Some agricultural and industrial residues have proven to be excellent choices as raw materials for producing bioactive compounds and have been proposed as potentially safe natural sources of antimicrobials and/or antioxidants for the food industry. Functional food ingredients containing bioactive compounds could be used as plant extracts by pharmaceutical and food industries. Bioactive food components influence health outcomes. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  8. Performance of wave function and density functional methods for water hydrogen bond spin-spin coupling constants.

    Science.gov (United States)

    García de la Vega, J M; Omar, S; San Fabián, J

    2017-04-01

    Spin-spin coupling constants in water monomer and dimer have been calculated using several wave function and density functional-based methods. CCSD, MCSCF, and SOPPA wave functions methods yield similar results, specially when an additive approach is used with the MCSCF. Several functionals have been used to analyze their performance with the Jacob's ladder and a set of functionals with different HF exchange were tested. Functionals with large HF exchange appropriately predict 1 J O H , 2 J H H and 2h J O O couplings, while 1h J O H is better calculated with functionals that include a reduced fraction of HF exchange. Accurate functionals for 1 J O H and 2 J H H have been tested in a tetramer water model. The hydrogen bond effects on these intramolecular couplings are additive when they are calculated by SOPPA(CCSD) wave function and DFT methods. Graphical Abstract Evaluation of the additive effect of the hydrogen bond on spin-spin coupling constants of water using WF and DFT methods.

  9. Complications impaired endothelial progenitor cell function in Type 2 diabetic patients with or without critical leg ischaemia: implication for impaired neovascularization in diabetes.

    Science.gov (United States)

    Chen, M-C; Sheu, J-J; Wang, P-W; Chen, C-Y; Kuo, M-C; Hsieh, C-J; Chen, J-F; Chang, H-W

    2009-02-01

    This study tested the hypothesis that migratory function of endothelial progenitor cells (EPCs) is impaired in Type 2 diabetic patients with or without critical leg ischaemia. Seventy-four patients were classified into four groups: Type 2 diabetic (n = 21) and non-diabetic patients (n = 10) with critical leg ischaemia and Type 2 diabetic patients without lower extremity vascular disease (n = 30) and healthy subjects (n = 13). The number and functional activity of circulating and cultured EPCs were determined. The migratory function of cultured EPCs was significantly impaired in diabetic patients without (median, 48, interquartile range, 46, 49 count/view/well) and with (median, 51, interquartile range, 46, 60 count/view/well) critical leg ischaemia and non-diabetic patients with critical leg ischaemia (median, 49, interquartile range, 47, 55 count/view/well) compared with healthy subjects (median, 63, interquartile range, 57, 65 count/view/well) (P interquartile range, 1600, 6600/10(6) cytometric events) than Type 2 diabetic patients with critical leg ischaemia (median, 5300, interquartile range, 2400, 11,100/10(6) cytometric events), non-diabetic patients with critical leg ischaemia (median, 5550, interquartile range, 2000, 32,100/10(6) cytometric events) and healthy subjects (median, 5400, interquartile range, 2700, 8700/10(6) cytometric events) (P = 0.413). The migratory function of EPCs is impaired in patients with Type 2 diabetes, even in those without critical leg ischaemia. These findings present an important new insight into the pathogenesis of impaired neovascularization and critical limb ischaemia in diabetic patients and provide avenues of future clinical study.

  10. Validation of the Society for Vascular Surgery's objective performance goals for critical limb ischemia in everyday vascular surgery practice.

    Science.gov (United States)

    Goodney, Philip P; Schanzer, Andres; Demartino, Randall R; Nolan, Brian W; Hevelone, Nathanael D; Conte, Michael S; Powell, Richard J; Cronenwett, Jack L

    2011-07-01

    To develop standardized metrics for expected outcomes in lower extremity revascularization for critical limb ischemia (CLI), the Society for Vascular Surgery (SVS) has developed objective performance goals (OPGs) based on aggregate data from randomized trials of lower extremity bypass (LEB). It remains unknown, however, if these targets can be achieved in everyday vascular surgery practice. We applied SVS OPG criteria to 1039 patients undergoing 1039 LEB operations for CLI with autogenous vein (excluding patients on dialysis) within the Vascular Study Group of New England (VSGNE). Each of the individual OPGs was calculated within the VSGNE dataset, along with its surrounding 95% confidence intervals (CIs) and compared to published SVS OPGs using χ(2) comparisons and survival analysis. Across most risk strata, patients in the VSGNE and SVS OPG cohorts were similar (clinical high-risk [age >80 years and tissue loss]: 15.3% VSGNE; 16.2% SVS OPG; P = .58; anatomic high risk [infrapopliteal target artery]: 57.8% VSGNE; 60.2% SVS OPG; P = .32). However, the proportion of VSGNE patients designated as conduit high-risk (lack of single-segment great saphenous vein) was lower (10.2% VSGNE; 26.9% SVS OPG;P Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved.

  11. The 'Critical Power' Concept: Applications to Sports Performance with a Focus on Intermittent High-Intensity Exercise.

    Science.gov (United States)

    Jones, Andrew M; Vanhatalo, Anni

    2017-03-01

    The curvilinear relationship between power output and the time for which it can be sustained is a fundamental and well-known feature of high-intensity exercise performance. This relationship 'levels off' at a 'critical power' (CP) that separates power outputs that can be sustained with stable values of, for example, muscle phosphocreatine, blood lactate, and pulmonary oxygen uptake ([Formula: see text]), from power outputs where these variables change continuously with time until their respective minimum and maximum values are reached and exercise intolerance occurs. The amount of work that can be done during exercise above CP (the so-called W') is constant but may be utilized at different rates depending on the proximity of the exercise power output to CP. Traditionally, this two-parameter CP model has been employed to provide insights into physiological responses, fatigue mechanisms, and performance capacity during continuous constant power output exercise in discrete exercise intensity domains. However, many team sports (e.g., basketball, football, hockey, rugby) involve frequent changes in exercise intensity and, even in endurance sports (e.g., cycling, running), intensity may vary considerably with environmental/course conditions and pacing strategy. In recent years, the appeal of the CP concept has been broadened through its application to intermittent high-intensity exercise. With the assumptions that W' is utilized during work intervals above CP and reconstituted during recovery intervals below CP, it can be shown that performance during intermittent exercise is related to four factors: the intensity and duration of the work intervals and the intensity and duration of the recovery intervals. However, while the utilization of W' may be assumed to be linear, studies indicate that the reconstitution of W' may be curvilinear with kinetics that are highly variable between individuals. This has led to the development of a new CP model for intermittent exercise in

  12. An Amino Acid of Human Parainfluenza Virus Type 3 Nucleoprotein Is Critical for Template Function and Cytoplasmic Inclusion Body Formation

    Science.gov (United States)

    Zhang, Shengwei; Chen, Longyun; Zhang, Guangyuan; Yan, Qin; Yang, Xiaodan; Ding, Binbin; Tang, Qiaopeng; Sun, Shengjun; Hu, Zhulong

    2013-01-01

    The nucleoprotein (N) and phosphoprotein (P) interaction of nonsegmented negative-strand RNA viruses is essential for viral replication; this includes N0-P (N0, free of RNA) interaction and the interaction of N-RNA with P. The precise site(s) within N that mediates the N-P interaction and the detailed regulating mechanism, however, are less clear. Using a human parainfluenza virus type 3 (HPIV3) minigenome assay, we found that an N mutant (NL478A) did not support reporter gene expression. Using in vivo and in vitro coimmunoprecipitation, we found that NL478A maintains the ability to form NL478A0-P, to self-assemble, and to form NL478A-RNA but that NL478A-RNA does not interact with P. Using an immunofluorescence assay, we found that N-P interaction provides the minimal requirement for the formation of cytoplasmic inclusion bodies, which contain viral RNA, N, P, and polymerase in HPIV3-infected cells. NL478A was unable to form inclusion bodies when coexpressed with P, but the presence of N rescued the ability of NL478A to form inclusion bodies and the transcriptional function of NL478A, thereby suggesting that hetero-oligomers formed by N and NL478A are functional and competent to form inclusion bodies. Furthermore, we found that NL478A is also defective in virus growth. To our knowledge, we are the first to use a paramyxovirus to identify a precise amino acid within N that is critical for N-RNA and P interaction but not for N0-P interaction for the formation of inclusion bodies, which appear to be bona fide sites of RNA synthesis. PMID:24027324

  13. Merging assistance function with task distribution model to enhance user performance in collaborative virtual environment

    International Nuclear Information System (INIS)

    Khalid, S.; Alam, A.

    2016-01-01

    Collaborative Virtual Environments (CVEs) falls under Virtual Reality (VR) where two or more users manipulate objects collaboratively. In this paper we have made some experiments to make assembly from constituents parts scattered in Virtual Environment (VE) based on task distribution model using assistance functions for checking and enhancing user performance. The CVEs subjects setting on distinct connected machines via local area network. In this perspective, we consider the effects of assistance function with oral communication on collaboration, co-presence and users performance. Twenty subjects performed collaboratively an assembly task on static and dynamic based task distribution. We examine the degree of influence of assistance function with oral communications on user's performance based on task distribution model. The results show that assistance functions with oral communication based on task distribution model not only increase user performance but also enhance the sense of copresence and awareness. (author)

  14. In-depth performance evaluation of PFP and ESG sequence-based function prediction methods in CAFA 2011 experiment

    Directory of Open Access Journals (Sweden)

    Chitale Meghana

    2013-02-01

    Full Text Available Abstract Background Many Automatic Function Prediction (AFP methods were developed to cope with an increasing growth of the number of gene sequences that are available from high throughput sequencing experiments. To support the development of AFP methods, it is essential to have community wide experiments for evaluating performance of existing AFP methods. Critical Assessment of Function Annotation (CAFA is one such community experiment. The meeting of CAFA was held as a Special Interest Group (SIG meeting at the Intelligent Systems in Molecular Biology (ISMB conference in 2011. Here, we perform a detailed analysis of two sequence-based function prediction methods, PFP and ESG, which were developed in our lab, using the predictions submitted to CAFA. Results We evaluate PFP and ESG using four different measures in comparison with BLAST, Prior, and GOtcha. In addition to the predictions submitted to CAFA, we further investigate performance of a different scoring function to rank order predictions by PFP as well as PFP/ESG predictions enriched with Priors that simply adds frequently occurring Gene Ontology terms as a part of predictions. Prediction accuracies of each method were also evaluated separately for different functional categories. Successful and unsuccessful predictions by PFP and ESG are also discussed in comparison with BLAST. Conclusion The in-depth analysis discussed here will complement the overall assessment by the CAFA organizers. Since PFP and ESG are based on sequence database search results, our analyses are not only useful for PFP and ESG users but will also shed light on the relationship of the sequence similarity space and functions that can be inferred from the sequences.

  15. Performance of SEM scintillation detector evaluated by modulation transfer function and detective quantum efficiency function.

    Science.gov (United States)

    Bok, Jan; Schauer, Petr

    2014-01-01

    In the paper, the SEM detector is evaluated by the modulation transfer function (MTF) which expresses the detector's influence on the SEM image contrast. This is a novel approach, since the MTF was used previously to describe only the area imaging detectors, or whole imaging systems. The measurement technique and calculation of the MTF for the SEM detector are presented. In addition, the measurement and calculation of the detective quantum efficiency (DQE) as a function of the spatial frequency for the SEM detector are described. In this technique, the time modulated e-beam is used in order to create well-defined input signal for the detector. The MTF and DQE measurements are demonstrated on the Everhart-Thornley scintillation detector. This detector was alternated using the YAG:Ce, YAP:Ce, and CRY18 single-crystal scintillators. The presented MTF and DQE characteristics show good imaging properties of the detectors with the YAP:Ce or CRY18 scintillator, especially for a specific type of the e-beam scan. The results demonstrate the great benefit of the description of SEM detectors using the MTF and DQE. In addition, point-by-point and continual-sweep e-beam scans in SEM were discussed and their influence on the image quality was revealed using the MTF. © 2013 Wiley Periodicals, Inc.

  16. Modelling of critical functions of nuclear reactors using Fild Programmable Gate Array; Modelagem de funcoes criticas de reatores nucleares utilizando Fild Programmable Gate Array

    Energy Technology Data Exchange (ETDEWEB)

    Teixeira, Pamela Iara Nolasco

    2016-07-01

    This paper proposes the development of a method using FPGA for critical security functions of a nuclear reactor. It was implemented two critical safety functions in VHDL, which is a way to describe, through a program, the behavior of a circuit or digital component. Two critical security functions, FCS Core Cooling, responsible for cooling the reactor core in the charts of the plant and also in the event of accidents involving loss of coolant and FCS Heat Transfer, responsible for cooling the reactor core in the event an accident with loss of coolant were implemented. In this Dissertation it was chosen the use of FPGA, because - due to the effects of aging, obsolescence issues, environmental degradation and mechanical failures - nuclear power plants need to replace their older systems by new ones based on digital technology. The technologies obtained using a system described in hardware language can be implemented in a programmable device, having the advantage of changing the code at any time. (author)

  17. Model-based Development of Safety-critical Functions and ISO 26262 Work Products using modified EAST-ADL

    Directory of Open Access Journals (Sweden)

    Bülent Sari

    2017-07-01

    Full Text Available Safety is becoming more and more important with the ever increasing level of safety related E/E Systems built into the cars. Increasing functionality of vehicle systems through electrification of power train, in future even more by autonomous driving, leads to complexity in designing system, software and safety architecture. ISO 26262 aims to reduce the complexity and to approve the traceability of the different safety activities. This paper presents an approach about model-based development of system, software and safety architecture using Electronics Architecture and Software Technology – Architecture Description Language (EAST-ADL, being in line with the relevant standard ISO 26262. In particular, we briefly discuss how the main safety related activities, such as hazard analysis and risk assessment, developing functional and technical safety concepts and performing safety analysis can be performed model-based and how the activities can be related with system and software development. The state-of-art is also provided and compared with the proposed approach.

  18. Diurnal variation in the performance of rapid response systems: the role of critical care services-a review article.

    Science.gov (United States)

    Sundararajan, Krishnaswamy; Flabouris, Arthas; Thompson, Campbell

    2016-01-01

    The type of medical review before an adverse event influences patient outcome. Delays in the up-transfer of patients requiring intensive care are associated with higher mortality rates. Timely detection and response to a deteriorating patient constitute an important function of the rapid response system (RRS). The activation of the RRS for at-risk patients constitutes the system's afferent limb. Afferent limb failure (ALF), an important performance measure of rapid response systems, constitutes a failure to activate a rapid response team (RRT) despite criteria for calling an RRT. There are diurnal variations in hospital staffing levels, the performance of rapid response systems and patient outcomes. Fewer ward-based nursing staff at night may contribute to ALF. The diurnal variability in RRS activity is greater in unmonitored units than it is in monitored units for events that should result in a call for an RRT. RRT events include a significant abnormality in either the pulse rate, blood pressure, conscious state or respiratory rate. There is also diurnal variation in RRT summoning rates, with most activations occurring during the day. The reasons for this variation are mostly speculative, but the failure of the afferent limb of RRT activation, particularly at night, may be a factor. The term "circadian variation/rhythm" applies to physiological variations over a 24-h cycle. In contrast, diurnal variation applies more accurately to extrinsic systems. Circadian rhythm has been demonstrated in a multitude of bodily functions and disease states. For example, there is an association between disrupted circadian rhythms and abnormal vital parameters such as anomalous blood pressure, irregular pulse rate, aberrant endothelial function, myocardial infarction, stroke, sleep-disordered breathing and its long-term consequences of hypertension, heart failure and cognitive impairment. Therefore, diurnal variation in patient outcomes may be extrinsic, and more easily modifiable

  19. SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice.

    Science.gov (United States)

    Qin, Kunhua; Zhang, Ning; Zhang, Zhao; Nipper, Michael; Zhu, Zhenxin; Leighton, Jake; Xu, Kexin; Musi, Nicolas; Wang, Pei

    2018-04-01

    Better understanding of how genetic and epigenetic components control beta cell differentiation and function is key to the discovery of novel therapeutic approaches to prevent beta cell dysfunction and failure in the progression of type 2 diabetes. Our goal was to elucidate the role of histone deacetylase sirtuin 6 (SIRT6) in beta cell development and homeostasis. Sirt6 endocrine progenitor cell conditional knockout and beta cell-specific knockout mice were generated using the Cre-loxP system. Mice were assayed for islet morphology, glucose tolerance, glucose-stimulated insulin secretion and susceptibility to streptozotocin. Transcriptional regulatory functions of SIRT6 in primary islets were evaluated by RNA-Seq analysis. Reverse transcription-quantitative (RT-q)PCR and immunoblot were used to verify and investigate the gene expression changes. Chromatin occupancies of SIRT6, H3K9Ac, H3K56Ac and active RNA polymerase II were evaluated by chromatin immunoprecipitation. Deletion of Sirt6 in pancreatic endocrine progenitor cells did not affect endocrine morphology, beta cell mass or insulin production but did result in glucose intolerance and defective glucose-stimulated insulin secretion in mice. Conditional deletion of Sirt6 in adult beta cells reproduced the insulin secretion defect. Loss of Sirt6 resulted in aberrant upregulation of thioredoxin-interacting protein (TXNIP) in beta cells. SIRT6 deficiency led to increased acetylation of histone H3 lysine residue at 9 (H3K9Ac), acetylation of histone H3 lysine residue at 56 (H3K56Ac) and active RNA polymerase II at the promoter region of Txnip. SIRT6-deficient beta cells exhibited a time-dependent increase in H3K9Ac, H3K56Ac and TXNIP levels. Finally, beta cell-specific SIRT6-deficient mice showed increased sensitivity to streptozotocin. Our results reveal that SIRT6 suppresses Txnip expression in beta cells via deacetylation of histone H3 and plays a critical role in maintaining beta cell function and viability

  20. Poly-ε-caprolactone Coated and Functionalized Porous Titanium and Magnesium Implants for Enhancing Angiogenesis in Critically Sized Bone Defects.

    Science.gov (United States)

    Roland, Laura; Grau, Michael; Matena, Julia; Teske, Michael; Gieseke, Matthias; Kampmann, Andreas; Beyerbach, Martin; Murua Escobar, Hugo; Haferkamp, Heinz; Gellrich, Nils-Claudius; Nolte, Ingo

    2015-12-22

    For healing of critically sized bone defects, biocompatible and angiogenesis supporting implants are favorable. Murine osteoblasts showed equal proliferation behavior on the polymers poly-ε-caprolactone (PCL) and poly-(3-hydroxybutyrate)/poly-(4-hydroxybutyrate) (P(3HB)/P(4HB)). As vitality was significantly better for PCL, it was chosen as a suitable coating material for further experiments. Titanium implants with 600 µm pore size were evaluated and found to be a good implant material for bone, as primary osteoblasts showed a vitality and proliferation onto the implants comparable to well bottom (WB). Pure porous titanium implants and PCL coated porous titanium implants were compared using Live Cell Imaging (LCI) with Green fluorescent protein (GFP)-osteoblasts. Cell count and cell covered area did not differ between the implants after seven days. To improve ingrowth of blood vessels into porous implants, proangiogenic factors like Vascular Endothelial Growth Factor (VEGF) and High Mobility Group Box 1 (HMGB1) were incorporated into PCL coated, porous titanium and magnesium implants. An angiogenesis assay was performed to establish an in vitro method for evaluating the impact of metallic implants on angiogenesis to reduce and refine animal experiments in future. Incorporated concentrations of proangiogenic factors were probably too low, as they did not lead to any effect. Magnesium implants did not yield evaluable results, as they led to pH increase and subsequent cell death.

  1. Poly-ε-caprolactone Coated and Functionalized Porous Titanium and Magnesium Implants for Enhancing Angiogenesis in Critically Sized Bone Defects

    Directory of Open Access Journals (Sweden)

    Laura Roland

    2015-12-01

    Full Text Available For healing of critically sized bone defects, biocompatible and angiogenesis supporting implants are favorable. Murine osteoblasts showed equal proliferation behavior on the polymers poly-ε-caprolactone (PCL and poly-(3-hydroxybutyrate/poly-(4-hydroxybutyrate (P(3HB/P(4HB. As vitality was significantly better for PCL, it was chosen as a suitable coating material for further experiments. Titanium implants with 600 µm pore size were evaluated and found to be a good implant material for bone, as primary osteoblasts showed a vitality and proliferation onto the implants comparable to well bottom (WB. Pure porous titanium implants and PCL coated porous titanium implants were compared using Live Cell Imaging (LCI with Green fluorescent protein (GFP-osteoblasts. Cell count and cell covered area did not differ between the implants after seven days. To improve ingrowth of blood vessels into porous implants, proangiogenic factors like Vascular Endothelial Growth Factor (VEGF and High Mobility Group Box 1 (HMGB1 were incorporated into PCL coated, porous titanium and magnesium implants. An angiogenesis assay was performed to establish an in vitro method for evaluating the impact of metallic implants on angiogenesis to reduce and refine animal experiments in future. Incorporated concentrations of proangiogenic factors were probably too low, as they did not lead to any effect. Magnesium implants did not yield evaluable results, as they led to pH increase and subsequent cell death.

  2. RELATIONSHIPS BETWEEN FUNCTIONAL MOVEMENT TESTS AND PERFORMANCE TESTS IN YOUNG ELITE MALE BASKETBALL PLAYERS.

    Science.gov (United States)

    Gonzalo-Skok, Oliver; Serna, Jorge; Rhea, Matthew R; Marín, Pedro J

    2015-10-01

    Sprinting and jumping are two common and important components of high-level sport performance. The weight-bearing dorsiflexion test (WB-DF) and Star Excursion Balance Test (SEBT) are tools developed to identify athletes at risk for lower extremity injury and may be related to running and jumping performance among athletes. The purposes of the present study were: 1) to identify any relationships between functional movement tests (WB-DF and SEBT) and performance tests (jumping, sprinting and changing direction); 2) to examine any relationships between asymmetries in functional movements and performance tests. Descriptive cohort study. Fifteen elite male basketball players (age: 15.4 ± 0.9 years) were assessed during a three-week period to determine the reliability of functional screening tools and performance tests and to examine the relationships between these tests. Relative (intraclass correlation coefficient) and absolute (coefficient of variation) reliability were used to assess the reproducibility of the tests. Significant correlations were detected between certain functional movement tests and performance tests. Both left and right excursion composite scores related to slower performance times in sprint testing, demonstrating that greater dynamic reach relates to decreased quickness and acceleration among these elite basketball athletes. The various relationships between dynamic functional movement testing, speed, and jump performance provide guidance for the strength and conditioning professional when conducting and evaluating data in an effort to improve performance and reduce risk of injury. The results of the present study suggest that these functional and performance tests do not measure the same components of human movement, and could be paired as outcome measures for the clinical and sport assessment of lower extremity function. 2b.

  3. Enhancing catalytic performance of Au catalysts by noncovalent functionalized graphene using functional ionic liquids

    International Nuclear Information System (INIS)

    Li, Shuwen; Guo, Shujing; Yang, Honglei; Gou, Galian; Ren, Ren; Li, Jing; Dong, Zhengping; Jin, Jun; Ma, Jiantai

    2014-01-01

    Highlights: • The new catalyst was fabricated by a facile and environment-friendly approach. • The catalyst has excellent activity and reusability due to the synergistic effect. • The approach provides a green way to synthesize low cost Au-based catalysts. - Abstract: New catalyst, prepared through Au nanoparticles anchored on the Ionic Liquid of 3,4,9,10-perylene tetracarboxylic acid-noncovalent functionalized graphene (Au/PDIL-GS), was fabricated using a facile and environment-friendly approach. The information of the morphologies, sizes, dispersion of Au nanoparticles (NPs) and chemical composition for the as-prepared catalysts was verified by systematic characterizations, including transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), Raman spectra, X-ray diffraction (XRD) and X-Ray photoelectron spectroscopy (XPS). As a new catalyst, the resulting Au/PDIL-GS exhibited excellent catalytic activity in the reduction of 4-nitrophenol because of the synergistic effect between the PDIL-GS and Au NPs. The facile and environment-friendly approach provides a green way to effectively synthesize low cost Au-based catalysts for 4-NP reduction and is promising for the development of other useful materials

  4. Does RBC Storage Age Effect Inflammation, Immune Function and Susceptibility to Transfusion Associated Microchimerism in Critically Ill Patients? Adverse Effects of RBC Storage in Critically Ill Patients

    Science.gov (United States)

    2015-05-01

    Barnes S, Grizzle W, Miller D, Zhang H-G. A novel nanoparticle drug delivery system: The anti-inflammatory activity of curcumin is enhanced when...Ultracentrifugatio remove impuritie including seru protein an othe solubl contaminant fro th plasma whic ca affec functiona experimenta outcomes...applications. EVs used in functional assays should be ultracentrifuged using the 3-step differential centrifugation protocol, since the soluble serum

  5. Development of multi-functional streetscape green infrastructure using a performance index approach

    Czech Academy of Sciences Publication Activity Database

    Tiwary, A.; Williams, L. D.; Heidrich, O.; Namdeo, A.; Bandaru, V.; Calfapietra, Carlo

    2016-01-01

    Roč. 208, jan (2016), s. 209-220 ISSN 0269-7491 Institutional support: RVO:67179843 Keywords : Green infrastructure * Multi-functional * Pollution * Performance index * Streetscape Subject RIV: EH - Ecology, Behaviour Impact factor: 5.099, year: 2016

  6. Performance analysis of demodulation with diversity -- A combinatorial approach I: Symmetric function theoretical methods

    Directory of Open Access Journals (Sweden)

    Jean-Louis Dornstetter

    2002-12-01

    Full Text Available This paper is devoted to the presentation of a combinatorial approach, based on the theory of symmetric functions, for analyzing the performance of a family of demodulation methods used in mobile telecommunications.

  7. Performance analysis of demodulation with diversity -- A combinatorial approach I: Symmetric function theoretical methods

    OpenAIRE

    Jean-Louis Dornstetter; Daniel Krob; Jean-Yves Thibon; Ekaterina A. Vassilieva

    2002-01-01

    This paper is devoted to the presentation of a combinatorial approach, based on the theory of symmetric functions, for analyzing the performance of a family of demodulation methods used in mobile telecommunications.

  8. SCALE: A modular code system for performing standardized computer analyses for licensing evaluation: Functional modules F1-F8

    International Nuclear Information System (INIS)

    1997-03-01

    This Manual represents Revision 5 of the user documentation for the modular code system referred to as SCALE. The history of the SCALE code system dates back to 1969 when the current Computational Physics and Engineering Division at Oak Ridge National Laboratory (ORNL) began providing the transportation package certification staff at the U.S. Atomic Energy Commission with computational support in the use of the new KENO code for performing criticality safety assessments with the statistical Monte Carlo method. From 1969 to 1976 the certification staff relied on the ORNL staff to assist them in the correct use of codes and data for criticality, shielding, and heat transfer analyses of transportation packages. However, the certification staff learned that, with only occasional use of the codes, it was difficult to become proficient in performing the calculations often needed for an independent safety review. Thus, shortly after the move of the certification staff to the U.S. Nuclear Regulatory Commission (NRC), the NRC staff proposed the development of an easy-to-use analysis system that provided the technical capabilities of the individual modules with which they were familiar. With this proposal, the concept of the Standardized Computer Analyses for Licensing Evaluation (SCALE) code system was born. This volume consists of the section of the manual dealing with eight of the functional modules in the code. Those are: BONAMI - resonance self-shielding by the Bondarenko method; NITAWL-II - SCALE system module for performing resonance shielding and working library production; XSDRNPM - a one-dimensional discrete-ordinates code for transport analysis; XSDOSE - a module for calculating fluxes and dose rates at points outside a shield; KENO IV/S - an improved monte carlo criticality program; COUPLE; ORIGEN-S - SCALE system module to calculate fuel depletion, actinide transmutation, fission product buildup and decay, and associated radiation source terms; ICE

  9. SCALE: A modular code system for performing standardized computer analyses for licensing evaluation: Functional modules F1-F8

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    This Manual represents Revision 5 of the user documentation for the modular code system referred to as SCALE. The history of the SCALE code system dates back to 1969 when the current Computational Physics and Engineering Division at Oak Ridge National Laboratory (ORNL) began providing the transportation package certification staff at the U.S. Atomic Energy Commission with computational support in the use of the new KENO code for performing criticality safety assessments with the statistical Monte Carlo method. From 1969 to 1976 the certification staff relied on the ORNL staff to assist them in the correct use of codes and data for criticality, shielding, and heat transfer analyses of transportation packages. However, the certification staff learned that, with only occasional use of the codes, it was difficult to become proficient in performing the calculations often needed for an independent safety review. Thus, shortly after the move of the certification staff to the U.S. Nuclear Regulatory Commission (NRC), the NRC staff proposed the development of an easy-to-use analysis system that provided the technical capabilities of the individual modules with which they were familiar. With this proposal, the concept of the Standardized Computer Analyses for Licensing Evaluation (SCALE) code system was born. This volume consists of the section of the manual dealing with eight of the functional modules in the code. Those are: BONAMI - resonance self-shielding by the Bondarenko method; NITAWL-II - SCALE system module for performing resonance shielding and working library production; XSDRNPM - a one-dimensional discrete-ordinates code for transport analysis; XSDOSE - a module for calculating fluxes and dose rates at points outside a shield; KENO IV/S - an improved monte carlo criticality program; COUPLE; ORIGEN-S - SCALE system module to calculate fuel depletion, actinide transmutation, fission product buildup and decay, and associated radiation source terms; ICE.

  10. Study of functional-performance deficits in athletes with previous ankle sprains

    Directory of Open Access Journals (Sweden)

    hamid Babaee

    2008-04-01

    Full Text Available Abstract Background: Despite the importance of functional-performance deficits in athletes with history of ankle sprain few, studies have been carried out in this area. The aim of this research was to study relationship between previous ankle sprains and functional-performance deficits in athletes. Materials and methods: The subjects were 40 professional athletes selected through random sampling among volunteer participants in soccer, basketball, volleyball and handball teams of Lorestan province. The subjects were divided into 2 groups: Injured group (athletes with previous ankle sprains and healthy group (athletes without previous ankle sprains. In this descriptive study we used Functional-performance tests (figure 8 hop test and side hop test to determine ankle deficits and limitations. They participated in figure 8 hop test including hopping in 8 shape course with the length of 5 meters and side hop test including 10 side hop repetitions in course with the length of 30 centimeters. Time were recorded via stopwatch. Results: After data gathering and assessing information distributions, Pearson correlation was used to assess relationships, and independent T test to assess differences between variables. Finally the results showed that there is a significant relationship between previous ankle sprains and functional-performance deficits in the athletes. Conclusion: The athletes who had previous ankle sprains indicated functional-performance deficits more than healthy athletes in completion of mentioned functional-performance tests. The functional-performance tests (figure 8 hop test and side hop test are sensitive and suitable to assess and detect functional-performance deficits in athletes. Therefore we can use the figure 8 hop and side hop tests for goals such as prevention, assessment and rehabilitation of ankle sprains without spending too much money and time.

  11. PTSD is negatively associated with physical performance and physical function in older overweight military veterans

    OpenAIRE

    Hall, Katherine S.; Beckham, Jean C.; Bosworth, Hayden B.; Sloane, Richard; Pieper, Carl F.; Morey, Miriam C.

    2014-01-01

    This study examines the effect of posttraumatic stress disorder (PTSD) on function and physical performance in older overweight military Veterans with comorbid conditions. This is a secondary data analysis of older Veterans (mean age = 62.9 yr) participating in a physical activity counseling trial. Study participants with PTSD (n = 67) and without PTSD (n = 235) were identified. Self-reported physical function (36-item Short Form Health Survey) and directly measured physical performance (mobi...

  12. Effects of functional exercise training on performance and muscle strength after meniscectomy

    DEFF Research Database (Denmark)

    Ericsson, Y B; Dahlberg, L E; Roos, E M

    2008-01-01

    Muscular deficits and functional limitations have been found years after meniscectomy of the knee. The purpose of this randomized controlled trial was to examine the effect of functional exercise training on functional performance and isokinetic thigh muscle strength in middle-aged patients...... subsequent to meniscectomy for a degenerative tear. Four years after meniscectomy, 45 patients (29 men, 16 women) were randomized to functional exercise training, supervised by a physical therapist, three times weekly for 4 months or to no intervention. The exercise program comprised of postural stability...... training and functional strength and endurance exercises for leg and trunk muscles. Outcomes were three functional performance tests and isokinetic muscle strength. Thirty patients (16 exercisers/14 controls) completed the study. Compared with control patients, the exercise group showed significant...

  13. Water/sand flooded and immersed critical experiment and analysis performed in support of the TOPAZ-II Safety Program

    International Nuclear Information System (INIS)

    Glushkov, E.S.; Ponomarev-Stepnoi, N.N.; Bubelev, V.G.; Garin, V.P.; Gomin, E.A.; Kompanietz, G.V.; Krutoy, A.M.; Lobynstev, V.A.; Maiorov, L.V.; Polyakov, D.N.

    1994-01-01

    Presented is a brief description of the Narciss-M2 critical assemblies, which simulate accidental water/wet-sand immersion of the TOPAZ-II reactor as well as water-flooding of core cavities. Experimental results obtained from these critical assemblies, including experiments with several fuel elements removed from the core, are shown. These configurations with several extracted fuel elements simulate a proposed fuel-out anticriticality-device modification to the TOPAZ-II reactor. Preliminary computational analysis of these experiments using the Monte Carlo neutron-transport method is outlined. Nuclear criticality safety of the TOPAZ-II reactor with an incorporated anticriticality unit is demonstrated

  14. Effects of a multicomponent exercise on dual-task performance and executive function among older adults

    Directory of Open Access Journals (Sweden)

    Ray-Yau Wang

    2018-06-01

    Full Text Available Summary: Background: Previous studies showed that multicomponent exercise enhanced physical and cognitive functions. This study aimed to investigate the effects of a multicomponent exercise on dual-task performance and executive function and to demonstrate the relationship between improvement in dual-task performance and enhancement in executive function among the elderly. Methods: A total of 27 people completed the intervention, with 16 in the experimental group and 11 in the control group. The 12-week multicomponent exercise lasted 1 h per day and 3 days per week. Participants' gait performance was assessed in dual-task conditions and executive function was examined at both pre- and post-intervention. Results: Results showed significant interaction effects of time x group on all selected gait parameters in both dual-task conditions and the Executive Interview. Compared with the control group, the experimental group showed greater improvements in most measures following intervention. Improved dual-task performance was correlated with enhanced executive function (r = 0.46–0.75. Conclusion: Our results suggested that a multicomponent exercise positively affects dual-task performance and executive function in the elderly. Keywords: Dual-task, Executive function, Exercise, Gait, Older adults

  15. Contractual Alliance Governance: Impact of Different Contract Functions on Alliance Performance

    NARCIS (Netherlands)

    Faems, D.L.M.; Alberink, Rutger; Groen, Arend J.; Klein Woolthuis, Rosalinde

    2010-01-01

    Recent research on alliance governance has emphasized that contracts can have both a control and coordination function. In this paper, we test the impact of these different contract functions on alliance performance. Conducting structural equation analyses on a sample of 270 Dutch technology

  16. The Interaction of Functional and Dysfunctional Emotions during Balance Beam Performance

    Science.gov (United States)

    Cottyn, Jorge; De Clercq, Dirk; Crombez, Geert; Lenoir, Matthieu

    2012-01-01

    The interaction between functional and dysfunctional emotions, as one of the major tenets of the Individual Zones of Optimal Functioning (IZOF) model (Hanin, 2000), was studied in a sport specific setting. Fourteen female gymnasts performed three attempts of a compulsory balance beam routine at three different heights. Heart rate and self-report…

  17. Validity of the German Version of the Continuous-Scale Physical Functional Performance 10 Test

    Directory of Open Access Journals (Sweden)

    Irene Härdi

    2017-01-01

    Full Text Available Background. The Continuous-Scale Physical Functional Performance 10 Test (CS-PFP 10 quantitatively assesses physical functional performance in older adults who have a broad range of physical functional ability. This study assessed the validity and reliability of the CS-PFP 10 German version. Methods. Forward-translations and backtranslations as well as cultural adaptions of the test were conducted. Participants were German-speaking Swiss community-dwelling adults aged 64 and older. Concurrent validity was assessed using Pearson correlation coefficients between CS-PFP 10 and gait velocity, Timed Up and Go Test, hand grip strength, SF-36 physical function domain, and Freiburger Physical Activity Questionnaire. Internal consistency was calculated by Cronbach’s alpha. Results. Backtranslation and cultural adaptions were accepted by the CS-PFP 10 developer. CS-PFP 10 total score and subscores (upper body strength, upper body flexibility, lower body strength, balance and coordination, and endurance correlated significantly with all measures of physical function tested. Internal consistency was high (Cronbach’s alpha 0.95–0.98. Conclusion. The CS-PFP 10 German version is valid and reliable for measuring physical functional performance in German-speaking Swiss community-dwelling older adults. Quantifying physical function is essential for clinical practice and research and provides meaningful insight into physical functional performance of older adults. This trial is registered with ClinicalTrials.gov NCT01539200.

  18. Conflict Detection Performance Analysis for Function Allocation Using Time-Shifted Recorded Traffic Data

    Science.gov (United States)

    Guerreiro, Nelson M.; Butler, Ricky W.; Maddalon, Jeffrey M.; Hagen, George E.; Lewis, Timothy A.

    2015-01-01

    The performance of the conflict detection function in a separation assurance system is dependent on the content and quality of the data available to perform that function. Specifically, data quality and data content available to the conflict detection function have a direct impact on the accuracy of the prediction of an aircraft's future state or trajectory, which, in turn, impacts the ability to successfully anticipate potential losses of separation (detect future conflicts). Consequently, other separation assurance functions that rely on the conflict detection function - namely, conflict resolution - are prone to negative performance impacts. The many possible allocations and implementations of the conflict detection function between centralized and distributed systems drive the need to understand the key relationships that impact conflict detection performance, with respect to differences in data available. This paper presents the preliminary results of an analysis technique developed to investigate the impacts of data quality and data content on conflict detection performance. Flight track data recorded from a day of the National Airspace System is time-shifted to create conflicts not present in the un-shifted data. A methodology is used to smooth and filter the recorded data to eliminate sensor fusion noise, data drop-outs and other anomalies in the data. The metrics used to characterize conflict detection performance are presented and a set of preliminary results is discussed.

  19. Static, dynamic balance and functional performance in subjects with and without plantar fasciitis

    Directory of Open Access Journals (Sweden)

    Geiseane Aguiar Gonçalves

    Full Text Available Abstract Introduction: Plantar fasciitis (PF is characterized by non-inflammatory degeneration and pain under the heel, and is one of the most common foot complaints. The compensations and adjustments made to decrease the discomfort caused by the disease are clinical findings and can be a factor that contributes to impaired balance and decreased functional performance. Objective: To compare functional performance as well as static and dynamic balance among subjects with and without PF. Methods: The sample consisted of 124 subjects of both sexes aged 20-60 years. Participants were divided into two groups: a bilateral PF group (PFG; n = 62 and a control group (CG, n = 62. The following outcomes were analyzed: static and dynamic balance (using functional tests and functional performance (using a questionnaire. We used Student’s t test for independent samples to compare variables between the groups. The alpha error was set at 0.05. Results: Subjects with PF showed greater impairment in their overall dynamic balance performance (p < 0.001 than the control group, except for left posteromedial movement (p = 0.19. The CG showed showed better functional performance (p < 0.001 than the PF group. There was no difference between groups for the variable static balance on stable (p = 0.160 and unstable surfaces (p = 0.085. Conclusion: Subjects with PF displayed smaller reach distances in the overall Star Excursion Balance Test (SEBT, demonstrating a deficit in dynamic balance and functional performance when compared with healthy subjects.

  20. Relationship between functional vision and balance and mobility performance in community-dwelling older adults.

    Science.gov (United States)

    Aartolahti, Eeva; Häkkinen, Arja; Lönnroos, Eija; Kautiainen, Hannu; Sulkava, Raimo; Hartikainen, Sirpa

    2013-10-01

    Vision is an important prerequisite for balance control and mobility. The role of objectively measured visual functions has been previously studied but less is known about associations of functional vision, that refers to self-perceived vision-based ability to perform daily activities. The aim of the study was to investigate the relationship between functional vision and balance and mobility performance in a community-based sample of older adults. This study is part of a Geriatric Multidisciplinary Strategy for the Good Care of the Elderly project (GeMS). Participants (576) aged 76-100 years (mean age 81 years, 70 % women) were interviewed using a seven-item functional vision questionnaire (VF-7). Balance and mobility were measured by the Berg balance scale (BBS), timed up and go (TUG), chair stand test, and maximal walking speed. In addition, self-reported fear of falling, depressive symptoms (15-item Geriatric Depression Scale), cognition (Mini-Mental State Examination) and physical activity (Grimby) were assessed. In the analysis, participants were classified into poor, moderate, or good functional vision groups. The poor functional vision group (n = 95) had more comorbidities, depressed mood, cognition decline, fear of falling, and reduced physical activity compared to participants with moderate (n = 222) or good functional vision (n = 259). Participants with poor functional vision performed worse on all balance and mobility tests. After adjusting for gender, age, chronic conditions, and cognition, the linearity remained statistically significant between functional vision and BBS (p = 0.013), TUG (p = 0.010), and maximal walking speed (p = 0.008), but not between functional vision and chair stand (p = 0.069). Poor functional vision is related to weaker balance and mobility performance in community-dwelling older adults. This highlights the importance of widespread assessment of health, including functional vision, to prevent balance impairment and maintain

  1. Performance of Multi-chaotic PSO on a shifted benchmark functions set

    Energy Technology Data Exchange (ETDEWEB)

    Pluhacek, Michal; Senkerik, Roman; Zelinka, Ivan [Tomas Bata University in Zlín, Faculty of Applied Informatics Department of Informatics and Artificial Intelligence nám. T.G. Masaryka 5555, 760 01 Zlín (Czech Republic)

    2015-03-10

    In this paper the performance of Multi-chaotic PSO algorithm is investigated using two shifted benchmark functions. The purpose of shifted benchmark functions is to simulate the time-variant real-world problems. The results of chaotic PSO are compared with canonical version of the algorithm. It is concluded that using the multi-chaotic approach can lead to better results in optimization of shifted functions.

  2. Structure-function relationships in elderly resting-state-networks : influence of age and cognitive performance

    OpenAIRE

    Jockwitz, Christiane

    2016-01-01

    The aim of this work was to investigate the structure-function relationship in cognitive resting state networks in a large population-based elderly sample. The first study characterized the functional connectivity in four cognitive resting state networks with respect to age, gender and cognitive performance: Default Mode Network (DMN), executive, and left and right frontoparietal resting state networks. The second study assessed the structural correlates of the functional reorganization of th...

  3. Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls

    OpenAIRE

    Vasconcelos-Moreno, Mirela P.; Bücker, Joana; Bürke, Kelen P.; Czepielewski, Leticia; Santos, Barbara T.; Fijtman, Adam; Passos, Ives C.; Kunz, Mauricio; Bonnín, Caterina del Mar; Vieta i Pascual, Eduard, 1963-; Kapczinski, Flávio; Rosa, Adriane R.; Kauer-Sant'Anna, Marcia

    2016-01-01

    Objective: To assess cognitive performance and psychosocial functioning in patients with bipolar disorder (BD), in unaffected siblings, and in healthy controls. Methods: Subjects were patients with BD (n=36), unaffected siblings (n=35), and healthy controls (n=44). Psychosocial functioning was accessed using the Functioning Assessment Short Test (FAST). A sub-group of patients with BD (n=21), unaffected siblings (n=14), and healthy controls (n=22) also underwent a battery of neuropsychologic...

  4. Performance of Multi-chaotic PSO on a shifted benchmark functions set

    International Nuclear Information System (INIS)

    Pluhacek, Michal; Senkerik, Roman; Zelinka, Ivan

    2015-01-01

    In this paper the performance of Multi-chaotic PSO algorithm is investigated using two shifted benchmark functions. The purpose of shifted benchmark functions is to simulate the time-variant real-world problems. The results of chaotic PSO are compared with canonical version of the algorithm. It is concluded that using the multi-chaotic approach can lead to better results in optimization of shifted functions

  5. Habitats as surrogates of taxonomic and functional fish assemblages in coral reef ecosystems: a critical analysis of factors driving effectiveness.

    Directory of Open Access Journals (Sweden)

    Simon Van Wynsberge

    Full Text Available Species check-lists are helpful to establish Marine Protected Areas (MPAs and protect local richness, endemicity, rarity, and biodiversity in general. However, such exhaustive taxonomic lists (i.e., true surrogate of biodiversity require extensive and expensive censuses, and the use of estimator surrogates (e.g., habitats is an appealing alternative. In truth, surrogate effectiveness appears from the literature highly variable both in marine and terrestrial ecosystems, making it difficult to provide practical recommendations for managers. Here, we evaluate how the biodiversity reference data set and its inherent bias can influence effectiveness. Specifically, we defined habitats by geomorphology, rugosity, and benthic cover and architecture criteria, and mapped them with satellite images for a New-Caledonian site. Fish taxonomic and functional lists were elaborated from Underwater Visual Censuses, stratified according to geomorphology and exposure. We then tested if MPA networks designed to maximize habitat richness, diversity and rarity could also effectively maximize fish richness, diversity, and rarity. Effectiveness appeared highly sensitive to the fish census design itself, in relation to the type of habitat map used and the scale of analysis. Spatial distribution of habitats (estimator surrogate's distribution, quantity and location of fish census stations (target surrogate's sampling, and random processes in the MPA design all affected effectiveness to the point that one small change in the data set could lead to opposite conclusions. We suggest that previous conclusions on surrogacy effectiveness, either positive or negative, marine or terrestrial, should be considered with caution, except in instances where very dense data sets were used without pseudo-replication. Although this does not rule out the validity of using surrogates of species lists for conservation planning, the critical joint examination of both target and estimator

  6. The effect of caffeine ingestion on functional performance in older adults.

    Science.gov (United States)

    Duncan, M J; Clarke, N D; Tallis, J; Guimarães-Ferreira, L; Leddington Wright, S

    2014-12-01

    Caffeine is a widely used nutritional supplement which has been shown to enhance both physical and cognitive performance in younger adults. However, few studies have assessed the effect of caffeine ingestion on performance, particularly functional performance in older adults. The present study aims to assess the effect of acute caffeine ingestion on functional performance, manual dexterity and readiness to invest effort in older adults. 19 apparently healthy, volunteers (10 females and 9 males aged 61-79; 66 ± 2 years) performed tests of functional fitness and manual dexterity post ingestion of caffeine (3mg*kg-1) or placebo in a randomised order. Pre and 60 minutes post ingestion, participants also completed measures of readiness to invest physical (RTIPE) and mental (RTIME) effort. A series of repeated measures ANOVAS indicated enhanced performance in the following functional fitness tests; arm curls (P = .04), 8 foot up and go (P = .007), six minute walk (P = .016). Manual dexterity was also improved in the presence of caffeine (P = .001). RTIME increased (P = .015) pre to post ingestion in the caffeine condition but not in the placebo condition. There were no significant main effects or interactions for RTIPE or gender in any analysis (all P > .05). The results of this study suggest that acute caffeine ingestion positively enhances functional performance, manual dexterity and readiness to invest effort in apparently healthy older adults.

  7. Investigating the Correlation Between Pharmacy Student Performance on the Health Science Reasoning Test and a Critical Thinking Assignment

    OpenAIRE

    Nornoo, Adwoa O.; Jackson, Jonathan; Axtell, Samantha

    2017-01-01

    Objective. To determine whether there is a correlation between pharmacy students? scores on the Health Science Reasoning Test (HSRT) and their grade on a package insert assignment designed to assess critical thinking.

  8. The role of neuropsychological performance in the relationship between chronic pain and functional physical impairment.

    Science.gov (United States)

    Pulles, Wiesje L J A; Oosterman, Joukje M

    2011-12-01

      In this study, the relationship between pain intensity, neuropsychological, and physical function in adult chronic pain patients was examined.   Thirty participants with chronic pain completed neuropsychological tests tapping mental processing speed, memory, and executive function. Pain intensity was measured with three visual analog scales and the Pain Rating Index of the McGill Pain Questionnaire. A grip strength test, the 6-minute walk test, the Unipedal Stance Test and the Lifting Low Test were administered in order to obtain a performance-based measure of physical capacity. Self-reported physical ability was assessed with the Disability Rating Index and the Short Form-36 Physical Functioning, and Role Physical scales. Psychosocial function was examined using the Mental Health and Role Emotional subscales of the Short Form-36.   The study was set in two outpatient physical therapy clinics in The Netherlands.   The analysis showed that a lower mental processing speed was related to a higher level of pain, as well as to a lower performance-based and self-reported physical functioning. In addition, both performance-based and self-reported physical function revealed an inverse correlation with pain intensity. Psychosocial function turned out to be an important mediator of the relationship between pain and self-reported, but not performance-based, physical function. Mental processing speed, on the other hand, was found to mediate the relationship between pain and performance-based physical functioning.   The results suggest that in chronic pain patients, mental processing speed mediates the relationship between pain and physical function. Wiley Periodicals, Inc.

  9. SCALE: A modular code system for performing standardized computer analyses for licensing evaluation: Functional modules, F9-F11

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    This Manual represents Revision 5 of the user documentation for the modular code system referred to as SCALE. The history of the SCALE code system dates back to 1969 when the current Computational Physics and Engineering Division at Oak Ridge National Laboratory (ORNL) began providing the transportation package certification staff at the U.S. Atomic Energy Commission with computational support in the use of the new KENO code for performing criticality safety assessments with the statistical Monte Carlo method. From 1969 to 1976 the certification staff relied on the ORNL staff to assist them in the correct use of codes and data for criticality, shielding, and heat transfer analyses of transportation packages. However, the certification staff learned that, with only occasional use of the codes, it was difficult to become proficient in performing the calculations often needed for an independent safety review. Thus, shortly after the move of the certification staff to the U.S. Nuclear Regulatory Commission (NRC), the NRC staff proposed the development of an easy-to-use analysis system that provided the technical capabilities of the individual modules with which they were familiar. With this proposal, the concept of the Standardized Computer Analyses for Licensing Evaluation (SCALE) code system was born. This volume consists of the section of th